term name p.value Adjusted.p.value fold_change gene_coverage subcluster cluster subset_cluster REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.000338178211187015 0.0283075055599483 5.39962551066727 0.375 1.2 1 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00140166397667427 0.0638816505157335 5.14250048634978 0.357142857142857 1.2 1 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00367840678249935 0.0887181839236708 4.23500040052335 0.294117647058824 1.2 1 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00482378796946651 0.108956353659537 3.99972260049428 0.277777777777778 1.2 1 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00123534941876615 0.0638816505157335 3.38800032041868 0.235294117647059 1.2 1 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00123534941876615 0.0638816505157335 3.38800032041868 0.235294117647059 1.2 1 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00318345551087104 0.0816330661934111 3.25138740427277 0.225806451612903 1.2 1 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0173104549511504 0.278303407271574 2.99979195037071 0.208333333333333 1.2 1 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00549340957815385 0.120263412764814 2.96450028036635 0.205882352941176 1.2 1 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 9.7372514699894e-06 0.00197944412025642 2.87980027235588 0.2 1.2 1 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0114733451004495 0.209315000999227 2.87980027235588 0.2 1.2 1 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0205091312650553 0.317222758588845 2.87980027235588 0.2 1.2 1 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.29940277309738e-05 0.00586881268264697 2.84631422267732 0.197674418604651 1.2 1 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.49153756838293e-05 0.00710161995534323 2.78162526307102 0.193181818181818 1.2 1 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00290442997204693 0.0765371083374589 2.7572555799152 0.191489361702128 1.2 1 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.54473430954806e-06 0.00129343138449738 2.67078251065263 0.185483870967742 1.2 1 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.54473430954806e-06 0.00129343138449738 2.67078251065263 0.185483870967742 1.2 1 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.54473430954806e-06 0.00129343138449738 2.67078251065263 0.185483870967742 1.2 1 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.028005791157614 0.352674697498095 2.66648173366285 0.185185185185185 1.2 1 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00013705335521786 0.0150020711134627 2.64809220446518 0.183908045977011 1.2 1 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0323262827483931 0.380167771495566 2.57125024317489 0.178571428571429 1.2 1 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.35573382773642e-05 0.00904420923686892 2.53315764697971 0.175925925925926 1.2 1 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00114660084432351 0.0638816505157335 2.46298707504121 0.171052631578947 1.2 1 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0154726504531838 0.256018390638146 2.45836608615746 0.170731707317073 1.2 1 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.0101245470568636 0.189568821867327 2.45089384881351 0.170212765957447 1.2 1 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.000390856794977023 0.0292731168027528 2.42509496619442 0.168421052631579 1.2 1 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.000390856794977023 0.0292731168027528 2.42509496619442 0.168421052631579 1.2 1 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0270631879674258 0.343847468550419 2.39983356029657 0.166666666666667 1.2 1 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0421533288401226 0.454425658632534 2.39983356029657 0.166666666666667 1.2 1 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0175549505020249 0.278303407271574 2.39983356029657 0.166666666666667 1.2 1 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00562297376631987 0.121234722264745 2.36049202652121 0.163934426229508 1.2 1 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00851409257581269 0.161540716471753 2.35620022283663 0.163636363636364 1.2 1 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.000283419038537923 0.0268870194559643 2.33497319380206 0.162162162162162 1.2 1 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0305837526477326 0.371934283788867 2.33497319380206 0.162162162162162 1.2 1 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000626765410003912 0.0405403262925258 2.32711133119667 0.161616161616162 1.2 1 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0145668304739228 0.243865879581083 2.3038402178847 0.16 1.2 1 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00470049815048082 0.107884014002165 2.29549297071845 0.159420289855072 1.2 1 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.022296026389698 0.319791368154923 2.29075021664672 0.159090909090909 1.2 1 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.022296026389698 0.319791368154923 2.29075021664672 0.159090909090909 1.2 1 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00349822695528525 0.0873329290766826 2.27352653080727 0.157894736842105 1.2 1 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00194361643612098 0.0638816505157335 2.23984465627679 0.155555555555556 1.2 1 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.0249697615329988 0.325981382215204 2.23984465627679 0.155555555555556 1.2 1 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0249697615329988 0.325981382215204 2.23984465627679 0.155555555555556 1.2 1 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0599258438157877 0.561016287828065 2.18166687299688 0.151515151515152 1.2 1 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0666630338984375 0.585314257384221 2.11750020026167 0.147058823529412 1.2 1 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.0132881369733518 0.227819504976864 2.08681179156223 0.144927536231884 1.2 1 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00321254512075265 0.0816330661934111 2.05700019453991 0.142857142857143 1.2 1 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0378390500710796 0.414192063470355 2.05700019453991 0.142857142857143 1.2 1 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0525919946101327 0.51612695400151 2.05700019453991 0.142857142857143 1.2 1 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0525919946101327 0.51612695400151 2.05700019453991 0.142857142857143 1.2 1 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0738033023703342 0.592789745380686 2.05700019453991 0.142857142857143 1.2 1 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.0176017615280686 0.278303407271574 1.99986130024714 0.138888888888889 1.2 1 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.0192461563697788 0.300959126529617 1.97246593996978 0.136986301369863 1.2 1 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0361405484778839 0.410724111445266 1.95240696430907 0.135593220338983 1.2 1 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0361405484778839 0.410724111445266 1.95240696430907 0.135593220338983 1.2 1 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0892730114142267 0.638369322826355 1.94581099483505 0.135135135135135 1.2 1 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0892730114142267 0.638369322826355 1.94581099483505 0.135135135135135 1.2 1 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.28651227505479e-09 6.09970696740296e-06 1.94359143856718 0.134980988593156 1.2 1 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0499205851833563 0.503808458978128 1.93832710639338 0.134615384615385 1.2 1 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 0.000125414376054712 0.0148720547604879 1.93708538499274 0.134529147982063 1.2 1 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0287070737310231 0.358334788765314 1.93419421277634 0.134328358208955 1.2 1 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.00356560628950059 0.0874803060337817 1.92742537913582 0.133858267716535 1.2 1 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.0228679112343011 0.319791368154923 1.91986684823725 0.133333333333333 1.2 1 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.0108000513777357 0.199590559876856 1.91007160921563 0.13265306122449 1.2 1 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.0126879789494419 0.222901161050072 1.87187017703132 0.13 1.2 1 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.0591883598883874 0.557781696166723 1.866537213564 0.12962962962963 1.2 1 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.0214739684195932 0.319791368154923 1.86340017623027 0.129411764705882 1.2 1 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.0214739684195932 0.319791368154923 1.86340017623027 0.129411764705882 1.2 1 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.0214739684195932 0.319791368154923 1.86340017623027 0.129411764705882 1.2 1 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0465562717302202 0.486778796976293 1.85793565958444 0.129032258064516 1.2 1 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.106279535656478 0.692701924137765 1.84602581561274 0.128205128205128 1.2 1 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.0822482421489001 0.603295095762293 1.83817038661013 0.127659574468085 1.2 1 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.0822482421489001 0.603295095762293 1.83817038661013 0.127659574468085 1.2 1 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 0.00051664319666832 0.0350087270885247 1.83260017331738 0.127272727272727 1.2 1 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.10742711119277e-06 0.00129343138449738 1.8252255247326 0.126760563380282 1.2 1 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0315452891564921 0.374200728790312 1.82265840022524 0.126582278481013 1.2 1 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.57822942973907e-05 0.0110971095259261 1.81830392623153 0.126279863481229 1.2 1 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 0.00183681766996845 0.0638816505157335 1.80971055366626 0.12568306010929 1.2 1 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0891002789451081 0.638369322826355 1.79987517022242 0.125 1.2 1 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.0891002789451081 0.638369322826355 1.79987517022242 0.125 1.2 1 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.115335600006242 0.692701924137765 1.79987517022242 0.125 1.2 1 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.115335600006242 0.692701924137765 1.79987517022242 0.125 1.2 1 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.115335600006242 0.692701924137765 1.79987517022242 0.125 1.2 1 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.00261889136204301 0.0703147624186266 1.78970638394998 0.124293785310734 1.2 1 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.0587581375793161 0.557418865169112 1.77218478298823 0.123076923076923 1.2 1 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 0.000421782688406322 0.0300098382801098 1.76539480297678 0.122605363984674 1.2 1 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.0962530085554379 0.655349431456402 1.76314302389135 0.122448979591837 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0632332479256057 0.584291635052837 1.7453334983975 0.121212121212121 1.2 1 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.0679147630706337 0.585314257384221 1.71928374469008 0.119402985074627 1.2 1 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0679147630706337 0.585314257384221 1.71928374469008 0.119402985074627 1.2 1 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0679147630706337 0.585314257384221 1.71928374469008 0.119402985074627 1.2 1 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.0244793801088971 0.325552877522996 1.71731208901956 0.119266055045872 1.2 1 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 0.00254029582595272 0.0695161723140523 1.71416682878326 0.119047619047619 1.2 1 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.0385256752037105 0.418488823014351 1.7031076879524 0.118279569892473 1.2 1 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.0261687267705282 0.335478362112267 1.70170016093756 0.118181818181818 1.2 1 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.111441716339223 0.692701924137765 1.69400016020934 0.117647058823529 1.2 1 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.144573273894995 0.710073666019745 1.67430248392784 0.116279069767442 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.0298016935270777 0.368763564252448 1.67131265806368 0.116071428571429 1.2 1 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.119466211707379 0.693096045844952 1.66142323405147 0.115384615384615 1.2 1 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.119466211707379 0.693096045844952 1.66142323405147 0.115384615384615 1.2 1 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 0.00165967133431272 0.0638816505157335 1.66142323405147 0.115384615384615 1.2 1 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 0.0216983242063914 0.319791368154923 1.66142323405147 0.115384615384615 1.2 1 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 0.00513737965713813 0.114226425814181 1.64560015563193 0.114285714285714 1.2 1 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0832041084545608 0.607176647850462 1.64560015563193 0.114285714285714 1.2 1 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.0337876083343541 0.394096448031032 1.64199138336081 0.114035087719298 1.2 1 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.0699251045364143 0.585314257384221 1.64039256020272 0.113924050632911 1.2 1 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0699251045364143 0.585314257384221 1.64039256020272 0.113924050632911 1.2 1 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.0699251045364143 0.585314257384221 1.64039256020272 0.113924050632911 1.2 1 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.0260534057376471 0.335478362112267 1.62394752200519 0.112781954887218 1.2 1 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.0449250385549842 0.473543184175871 1.61484127421825 0.11214953271028 1.2 1 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.113125755403547 0.692701924137765 1.59988904019771 0.111111111111111 1.2 1 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 0.0792022527704977 0.594756758915518 1.59988904019771 0.111111111111111 1.2 1 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 0.0792022527704977 0.594756758915518 1.59988904019771 0.111111111111111 1.2 1 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.165651716308184 0.720893566474792 1.59988904019771 0.111111111111111 1.2 1 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.176621375586415 0.720893566474792 1.56510884367167 0.108695652173913 1.2 1 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.176621375586415 0.720893566474792 1.56510884367167 0.108695652173913 1.2 1 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.176621375586415 0.720893566474792 1.56510884367167 0.108695652173913 1.2 1 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.00744329324164103 0.147108420595211 1.54275014590494 0.107142857142857 1.2 1 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.00744329324164103 0.147108420595211 1.54275014590494 0.107142857142857 1.2 1 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.00744329324164103 0.147108420595211 1.54275014590494 0.107142857142857 1.2 1 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.099889776306938 0.673664225994184 1.52460014418841 0.105882352941176 1.2 1 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.0747506837500173 0.592789745380686 1.52297129788051 0.105769230769231 1.2 1 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.163594209969779 0.720893566474792 1.51568435387152 0.105263157894737 1.2 1 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.119335957879384 0.693096045844952 1.51568435387151 0.105263157894737 1.2 1 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.199339527479924 0.742532921170228 1.49989597518535 0.104166666666667 1.2 1 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.199339527479924 0.742532921170228 1.49989597518535 0.104166666666667 1.2 1 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 0.0308420558588097 0.371934283788867 1.48685340148809 0.103260869565217 1.2 1 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.1513761542269 0.710073666019745 1.48225014018317 0.102941176470588 1.2 1 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.132973089480961 0.699191832615336 1.47682065249019 0.102564102564103 1.2 1 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.0692862987998385 0.585314257384221 1.47391352522151 0.102362204724409 1.2 1 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.211053904630434 0.758408349214917 1.4692858532428 0.102040816326531 1.2 1 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.18294724688151 0.720893566474792 1.4643052232318 0.101694915254237 1.2 1 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 0.140077087784572 0.709358348460663 1.45812672018019 0.10126582278481 1.2 1 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 0.140077087784572 0.709358348460663 1.45812672018019 0.10126582278481 1.2 1 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.109033491481083 0.692701924137765 1.45444458199792 0.101010101010101 1.2 1 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.147366233628548 0.710073666019745 1.43990013617794 0.1 1.2 1 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.16816826623447 0.720893566474792 1.43990013617794 0.1 1.2 1 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.222981901301094 0.772741546891361 1.43990013617794 0.1 1.2 1 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.0943176075000878 0.647225687310482 1.4280001350525 0.0991735537190083 1.2 1 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.154836258928061 0.710073666019745 1.42212359128685 0.0987654320987654 1.2 1 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.154836258928061 0.710073666019745 1.42212359128685 0.0987654320987654 1.2 1 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 0.000182229978757421 0.0185223756979865 1.4196198525698 0.0985915492957746 1.2 1 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.176858416931662 0.720893566474792 1.4196198525698 0.0985915492957746 1.2 1 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.203149950441406 0.742532921170228 1.41629521591273 0.0983606557377049 1.2 1 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.235105834449124 0.772741546891361 1.41166680017445 0.0980392156862745 1.2 1 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.103333531838934 0.692701924137765 1.4047806206614 0.0975609756097561 1.2 1 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.162482584534536 0.720893566474792 1.4047806206614 0.0975609756097561 1.2 1 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.0794123571285654 0.594756758915518 1.39345174468833 0.0967741935483871 1.2 1 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.108026932837802 0.692701924137765 1.39345174468833 0.0967741935483871 1.2 1 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 0.194790329382065 0.729438522922839 1.38072615797885 0.0958904109589041 1.2 1 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.178284364541424 0.720893566474792 1.37133346302661 0.0952380952380952 1.2 1 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.178284364541424 0.720893566474792 1.37133346302661 0.0952380952380952 1.2 1 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 0.000316014828887011 0.0281055688441385 1.36823089863062 0.0950226244343891 1.2 1 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00604813254418871 0.126566067799714 1.36717790707804 0.094949494949495 1.2 1 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.204016554204282 0.742532921170228 1.36206769638454 0.0945945945945946 1.2 1 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.204016554204282 0.742532921170228 1.36206769638454 0.0945945945945946 1.2 1 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 0.00375123661803939 0.0889668284578342 1.36172692388106 0.0945709281961471 1.2 1 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.259870359395535 0.808067972510682 1.35839635488485 0.0943396226415094 1.2 1 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.259870359395535 0.808067972510682 1.35839635488485 0.0943396226415094 1.2 1 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.186429256825526 0.720893566474792 1.35520012816747 0.0941176470588235 1.2 1 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 0.186429256825526 0.720893566474792 1.35520012816747 0.0941176470588235 1.2 1 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.186429256825526 0.720893566474792 1.35520012816747 0.0941176470588235 1.2 1 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 0.0975546223607078 0.661048702948987 1.34990637766682 0.09375 1.2 1 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.234848389408475 0.772741546891361 1.34990637766682 0.09375 1.2 1 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.234848389408475 0.772741546891361 1.34990637766682 0.09375 1.2 1 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 5.56398094050616e-06 0.00131959081305671 1.34787294864946 0.0936087798579729 1.2 1 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.157001491063255 0.710073666019745 1.34570106184854 0.0934579439252336 1.2 1 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.157001491063255 0.710073666019745 1.34570106184854 0.0934579439252336 1.2 1 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.133324543552392 0.699191832615336 1.33944198714227 0.0930232558139535 1.2 1 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.194729360624829 0.729438522922839 1.33944198714227 0.0930232558139535 1.2 1 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 0.123153045627531 0.693096045844952 1.33705012645094 0.0928571428571429 1.2 1 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 0.123153045627531 0.693096045844952 1.33705012645094 0.0928571428571429 1.2 1 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.150537557791893 0.710073666019745 1.33100012587877 0.092436974789916 1.2 1 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.128077976007732 0.695629617782455 1.32756750144065 0.0921985815602837 1.2 1 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 0.118395683440252 0.693096045844952 1.32622380963758 0.0921052631578947 1.2 1 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.222948785296035 0.772741546891361 1.32622380963758 0.0921052631578947 1.2 1 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.170408428216232 0.720893566474792 1.32100929924582 0.0917431192660551 1.2 1 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.193488872670772 0.729438522922839 1.30900012379813 0.0909090909090909 1.2 1 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.20129981732342 0.742532921170228 1.29591012256015 0.09 1.2 1 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.20129981732342 0.742532921170228 1.29591012256015 0.09 1.2 1 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.252418226714152 0.806685658975812 1.27586088015767 0.0886075949367089 1.2 1 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 0.157908748589022 0.71108907988031 1.2599126191557 0.0875 1.2 1 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.290598639789152 0.814019418149534 1.25208707493734 0.0869565217391304 1.2 1 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.290598639789152 0.814019418149534 1.25208707493734 0.0869565217391304 1.2 1 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.290598639789152 0.814019418149534 1.25208707493734 0.0869565217391304 1.2 1 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.233779399728043 0.772741546891361 1.2460674255386 0.0865384615384615 1.2 1 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.148621079203592 0.710073666019745 1.24531903669443 0.0864864864864865 1.2 1 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 0.192583613989939 0.729438522922839 1.24307925425434 0.0863309352517986 1.2 1 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.10684749581752 0.692701924137765 1.24226678415352 0.0862745098039216 1.2 1 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 0.0315559293428233 0.374200728790312 1.24036341318699 0.0861423220973783 1.2 1 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.153415024972652 0.710073666019745 1.23862377305629 0.0860215053763441 1.2 1 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.1743125176601 0.720893566474792 1.23672404334302 0.0858895705521472 1.2 1 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.179962660661316 0.720893566474792 1.22918304307873 0.0853658536585366 1.2 1 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.179962660661316 0.720893566474792 1.22918304307873 0.0853658536585366 1.2 1 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.171335028304256 0.720893566474792 1.22718761606074 0.0852272727272727 1.2 1 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.313635078421741 0.851722741591867 1.2168170164884 0.0845070422535211 1.2 1 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 0.0614778903042964 0.571784561457606 1.19991678014828 0.0833333333333333 1.2 1 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 0.214317095708371 0.768194526934537 1.19991678014828 0.0833333333333333 1.2 1 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 0.0128842644083237 0.22358912503713 1.19631342645414 0.0830830830830831 1.2 1 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 0.209507037352591 0.754755732032245 1.19281668085746 0.0828402366863905 1.2 1 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.116553240334762 0.693096045844952 1.19255532750934 0.0828220858895705 1.2 1 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 0.220813785334207 0.772741546891361 1.19227399810912 0.0828025477707006 1.2 1 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 0.260819551190281 0.808067972510682 1.19000011254375 0.0826446280991736 1.2 1 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 0.260819551190281 0.808067972510682 1.19000011254375 0.0826446280991736 1.2 1 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.157022029423701 0.710073666019745 1.18580011214654 0.0823529411764706 1.2 1 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 0.215661934712626 0.771072696221273 1.18580011214654 0.0823529411764706 1.2 1 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.363250884430489 0.8999016947118 1.18024601326061 0.0819672131147541 1.2 1 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 0.234048992593662 0.772741546891361 1.1772768409002 0.0817610062893082 1.2 1 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.324926127294018 0.851788162816933 1.17201173874949 0.0813953488372093 1.2 1 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.206322865523424 0.745171161522419 1.16563344357262 0.080952380952381 1.2 1 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.335579018509746 0.858865006006058 1.15854033945351 0.0804597701149425 1.2 1 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.335579018509746 0.858865006006058 1.15854033945351 0.0804597701149425 1.2 1 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.346278434553052 0.879918236373203 1.14537510832336 0.0795454545454545 1.2 1 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.389510085880736 0.917670285113058 1.14277788585551 0.0793650793650794 1.2 1 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 0.292907736600167 0.818875656546242 1.13948931639981 0.079136690647482 1.2 1 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 0.310967002770615 0.846091864134961 1.13377963478578 0.078740157480315 1.2 1 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00669835631527809 0.138141464299141 1.13084839963243 0.0785365853658537 1.2 1 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 0.142648840285959 0.710073666019745 1.1299664745791 0.07847533632287 1.2 1 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.245786636332846 0.796837664113957 1.12803236474769 0.0783410138248848 1.2 1 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.266356072134227 0.808067972510682 1.12492198138902 0.078125 1.2 1 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.325228819332751 0.851788162816933 1.10761548936765 0.0769230769230769 1.2 1 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 0.301904876031995 0.836942883215414 1.1015629457099 0.0765027322404372 1.2 1 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.32219377880424 0.851788162816933 1.10056061363919 0.0764331210191083 1.2 1 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 0.281803827527578 0.808067972510682 1.09768171816255 0.0762331838565022 1.2 1 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.389366051408393 0.917670285113058 1.09557619057017 0.0760869565217391 1.2 1 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.262152307441331 0.808067972510682 1.09162104186775 0.075812274368231 1.2 1 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.326542981686216 0.851788162816933 1.08829661455309 0.0755813953488372 1.2 1 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.400167804821678 0.930455533106613 1.08379580142426 0.0752688172043011 1.2 1 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 0.330273087548395 0.851788162816933 1.0780001019514 0.0748663101604278 1.2 1 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.241883569028437 0.787643749948435 1.07621401930825 0.0747422680412371 1.2 1 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.410965000156814 0.932955522626763 1.07226605885591 0.074468085106383 1.2 1 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.431102100582259 0.95109812267993 1.06659269346514 0.0740740740740741 1.2 1 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.396189958325662 0.930327245375275 1.06222141193455 0.0737704918032787 1.2 1 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 0.315062571778947 0.851788162816933 1.05875010013084 0.0735294117647059 1.2 1 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.366514265554492 0.8999016947118 1.04992718262975 0.0729166666666667 1.2 1 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.454443842393263 0.955204708605042 1.04089166470694 0.072289156626506 1.2 1 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.48010403212344 0.974275650379033 1.02850009726996 0.0714285714285714 1.2 1 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.19454378897172 0.729438522922839 1.0276365371547 0.0713685978169605 1.2 1 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.403306871406912 0.932955522626763 1.02327928459346 0.0710659898477157 1.2 1 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.425398755008268 0.939972714870753 1.02186461277144 0.0709677419354839 1.2 1 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.450624745866419 0.954800011072507 1.00246212012388 0.069620253164557 1.2 1 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 0.388298715878899 0.917670285113058 1.00100009466916 0.0695187165775401 1.2 1 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.505211805785402 0.99195997051917 0.999930650123569 0.0694444444444444 1.2 1 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.505211805785402 0.99195997051917 0.999930650123569 0.0694444444444444 1.2 1 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.505211805785402 0.99195997051917 0.999930650123569 0.0694444444444444 1.2 1 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.480314153307555 0.974275650379033 0.989244368366523 0.0687022900763359 1.2 1 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.480314153307555 0.974275650379033 0.989244368366523 0.0687022900763359 1.2 1 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.445754706015033 0.954800011072507 0.988772625701589 0.0686695278969957 1.2 1 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.475719897326212 0.974275650379033 0.98378270173648 0.0683229813664596 1.2 1 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.489534146184827 0.974275650379033 0.981750092848595 0.0681818181818182 1.2 1 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.511640280960568 0.99195997051917 0.981750092848595 0.0681818181818182 1.2 1 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.484039487253103 0.974275650379033 0.977709969009712 0.0679012345679012 1.2 1 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.522817974623596 0.99195997051917 0.970719192928948 0.0674157303370786 1.2 1 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.411330731670703 0.932955522626763 0.963405154404769 0.0669077757685353 1.2 1 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.533892006380606 1 0.959933424118626 0.0666666666666667 1.2 1 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.534915004905303 1 0.945919797489157 0.0656934306569343 1.2 1 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 0.507481651161585 0.99195997051917 0.94052574991405 0.0653188180404355 1.2 1 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 0.550194300105693 1 0.93652041377427 0.0650406504065041 1.2 1 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.55760351006193 1 0.933268606781998 0.0648148148148148 1.2 1 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 0.540867375806479 1 0.928967829792219 0.0645161290322581 1.2 1 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.561427510925974 1 0.925650087542961 0.0642857142857143 1.2 1 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.554305685335307 1 0.925237035295061 0.0642570281124498 1.2 1 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.587499185030258 1 0.909410612322909 0.0631578947368421 1.2 1 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.611178735523348 1 0.888827244554283 0.0617283950617284 1.2 1 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.619487105176599 1 0.883374316673582 0.0613496932515337 1.2 1 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.622112579988318 1 0.877987887913378 0.0609756097560976 1.2 1 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.648129553022647 1 0.874225082679463 0.0607142857142857 1.2 1 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.66397558374287 1 0.84700008010467 0.0588235294117647 1.2 1 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.671979340570006 1 0.84081759776814 0.0583941605839416 1.2 1 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.682776676652988 1 0.836071046812997 0.0580645161290323 1.2 1 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.685567927354564 1 0.826172209282424 0.0573770491803279 1.2 1 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.711396383086911 1 0.815037812930909 0.0566037735849057 1.2 1 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.711396383086911 1 0.815037812930909 0.0566037735849057 1.2 1 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.71021874393482 1 0.811211344325599 0.0563380281690141 1.2 1 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.726459412085123 1 0.785400074278876 0.0545454545454545 1.2 1 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.785398513201621 1 0.71995006808897 0.05 1.2 1 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 6.74556438128553e-05 0.000406734665871581 2.32099853157122 1 1.1 1 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00247377041640824 0.00907261675914673 2.32099853157122 1 1.1 1 1 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.00247377041640824 0.00907261675914673 2.32099853157122 1 1.1 1 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00247377041640824 0.00907261675914673 2.32099853157122 1 1.1 1 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 1.5975009513129e-05 0.000118398117381159 2.12758198727362 0.916666666666667 1.1 1 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.000148025675002942 0.000832571286676628 2.0888986784141 0.9 1.1 1 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000148025675002942 0.000832571286676628 2.0888986784141 0.9 1.1 1 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00386766404001543 0.0132939273645941 1.98942731277533 0.857142857142857 1.1 1 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00386766404001543 0.0132939273645941 1.98942731277533 0.857142857142857 1.1 1 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00386766404001543 0.0132939273645941 1.98942731277533 0.857142857142857 1.1 1 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 7.52732753848886e-05 0.000446307795302902 1.96392183440642 0.846153846153846 1.1 1 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0111194590868618 0.0312874499678427 1.93416544297602 0.833333333333333 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0111194590868618 0.0312874499678427 1.93416544297602 0.833333333333333 1.1 1 1 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0111194590868618 0.0312874499678427 1.93416544297602 0.833333333333333 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0111194590868618 0.0312874499678427 1.93416544297602 0.833333333333333 1.1 1 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000594464145534409 0.00281974159698488 1.89899879855827 0.818181818181818 1.1 1 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00163137183838142 0.00634273804922612 1.85679882525697 0.8 1.1 1 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00163137183838142 0.00634273804922612 1.85679882525697 0.8 1.1 1 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00163137183838142 0.00634273804922612 1.85679882525697 0.8 1.1 1 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00163137183838142 0.00634273804922612 1.85679882525697 0.8 1.1 1 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000254912053925613 0.0013385234418308 1.82364170337739 0.785714285714286 1.1 1 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 5.54924338739972e-11 2.82020476438207e-09 1.80522108011095 0.777777777777778 1.1 1 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.00438730346026337 0.0147243698678179 1.80522108011095 0.777777777777778 1.1 1 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00438730346026337 0.0147243698678179 1.80522108011095 0.777777777777778 1.1 1 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00438730346026337 0.0147243698678179 1.80522108011095 0.777777777777778 1.1 1 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00438730346026337 0.0147243698678179 1.80522108011095 0.777777777777778 1.1 1 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.13330661039082e-06 1.52141066659069e-05 1.78538348582401 0.769230769230769 1.1 1 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000672209151827271 0.00311656061738434 1.78538348582401 0.769230769230769 1.1 1 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000672209151827271 0.00311656061738434 1.78538348582401 0.769230769230769 1.1 1 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.9175714110883e-06 3.07533638368789e-05 1.76395888399413 0.76 1.1 1 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.9175714110883e-06 3.07533638368789e-05 1.76395888399413 0.76 1.1 1 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.10612290282921e-07 3.56787248895948e-06 1.74074889867841 0.75 1.1 1 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 4.48316812782396e-05 0.000286078396676838 1.74074889867841 0.75 1.1 1 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 4.48316812782396e-05 0.000286078396676838 1.74074889867841 0.75 1.1 1 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 4.48316812782396e-05 0.000286078396676838 1.74074889867841 0.75 1.1 1 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 4.48316812782396e-05 0.000286078396676838 1.74074889867841 0.75 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000275444411689493 0.00142529962848781 1.74074889867841 0.75 1.1 1 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000275444411689493 0.00142529962848781 1.74074889867841 0.75 1.1 1 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000275444411689493 0.00142529962848781 1.74074889867841 0.75 1.1 1 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00173877345690747 0.00670535129858898 1.74074889867841 0.75 1.1 1 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0115081657353027 0.0321100389045798 1.74074889867841 0.75 1.1 1 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0115081657353027 0.0321100389045798 1.74074889867841 0.75 1.1 1 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0115081657353027 0.0321100389045798 1.74074889867841 0.75 1.1 1 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000694452280829252 0.00316732562698726 1.70206558981889 0.733333333333333 1.1 1 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000694452280829252 0.00316732562698726 1.70206558981889 0.733333333333333 1.1 1 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 4.62774821769597e-05 0.000292589413972882 1.6879989320518 0.727272727272727 1.1 1 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 4.62774821769597e-05 0.000292589413972882 1.6879989320518 0.727272727272727 1.1 1 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000279327815065738 0.00143495841457959 1.67627671724588 0.722222222222222 1.1 1 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000279327815065738 0.00143495841457959 1.67627671724588 0.722222222222222 1.1 1 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 7.8309105718576e-06 6.08928182718763e-05 1.65785609397944 0.714285714285714 1.1 1 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00171545189658141 0.00663339143705258 1.65785609397944 0.714285714285714 1.1 1 1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 7.0952293210899e-09 1.65516579080507e-07 1.64404062652961 0.708333333333333 1.1 1 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.3352314103e-06 1.74315073106138e-05 1.63835190463851 0.705882352941177 1.1 1 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000678941525923503 0.00311656061738434 1.63835190463851 0.705882352941177 1.1 1 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.000678941525923503 0.00311656061738434 1.63835190463851 0.705882352941177 1.1 1 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.000678941525923503 0.00311656061738434 1.63835190463851 0.705882352941177 1.1 1 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 1.87660599100745e-05 0.000135553823614396 1.63329526295752 0.703703703703704 1.1 1 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0108178105779879 0.0308529410234188 1.62469897209985 0.7 1.1 1 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0108178105779879 0.0308529410234188 1.62469897209985 0.7 1.1 1 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0108178105779879 0.0308529410234188 1.62469897209985 0.7 1.1 1 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0108178105779879 0.0308529410234188 1.62469897209985 0.7 1.1 1 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 3.15966839635048e-06 3.25812183188894e-05 1.6176656432163 0.696969696969697 1.1 1 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 4.43462283155721e-05 0.000286078396676838 1.60684513724161 0.692307692307692 1.1 1 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 4.43462283155721e-05 0.000286078396676838 1.60684513724161 0.692307692307692 1.1 1 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00413854314333792 0.0140888681649997 1.60684513724161 0.692307692307692 1.1 1 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00413854314333792 0.0140888681649997 1.60684513724161 0.692307692307692 1.1 1 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00413854314333792 0.0140888681649997 1.60684513724161 0.692307692307692 1.1 1 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00413854314333792 0.0140888681649997 1.60684513724161 0.692307692307692 1.1 1 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.07676542175085e-10 8.20899220875407e-09 1.59568649045521 0.6875 1.1 1 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00161626959293673 0.00634273804922612 1.59568649045521 0.6875 1.1 1 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00161626959293673 0.00634273804922612 1.59568649045521 0.6875 1.1 1 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00161626959293673 0.00634273804922612 1.59568649045521 0.6875 1.1 1 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 3.03114197630795e-06 3.16791979778447e-05 1.59154185022026 0.685714285714286 1.1 1 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000256053779186404 0.00133957546978769 1.58249899879856 0.681818181818182 1.1 1 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 8.79904006938796e-08 1.58494101503026e-06 1.58025431936764 0.680851063829787 1.1 1 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.70514272147847e-05 0.000125073097559993 1.57228932783857 0.67741935483871 1.1 1 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.00729705433164e-07 3.4833947662365e-06 1.56415118431973 0.673913043478261 1.1 1 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.76971954178512e-08 1.43588453350133e-06 1.54733235438081 0.666666666666667 1.1 1 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.76971954178512e-08 1.43588453350133e-06 1.54733235438081 0.666666666666667 1.1 1 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000588382012941418 0.00280022610172454 1.54733235438081 0.666666666666667 1.1 1 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.58433805657309e-05 0.000118037332696519 1.54733235438081 0.666666666666667 1.1 1 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 1.58433805657309e-05 0.000118037332696519 1.54733235438081 0.666666666666667 1.1 1 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 9.55065651265677e-05 0.000554717723163697 1.54733235438081 0.666666666666667 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 9.55065651265677e-05 0.000554717723163697 1.54733235438081 0.666666666666667 1.1 1 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 9.55065651265677e-05 0.000554717723163697 1.54733235438081 0.666666666666667 1.1 1 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00375745112808573 0.0130246757916652 1.54733235438081 0.666666666666667 1.1 1 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00375745112808573 0.0130246757916652 1.54733235438081 0.666666666666667 1.1 1 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.99041563081645e-08 5.91022422590529e-07 1.53351688693098 0.660714285714286 1.1 1 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.7046723341332e-05 0.000511849121135188 1.52065421033976 0.655172413793103 1.1 1 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000214402425336471 0.00115566155777954 1.51757596295041 0.653846153846154 1.1 1 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 9.27293568618496e-07 1.28110558072245e-05 1.51369469450297 0.652173913043478 1.1 1 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000531044070599033 0.00255295848804873 1.51369469450297 0.652173913043478 1.1 1 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00132463791760038 0.00557962433456978 1.50864904552129 0.65 1.1 1 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00132463791760038 0.00557962433456978 1.50864904552129 0.65 1.1 1 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00132463791760038 0.00557962433456978 1.50864904552129 0.65 1.1 1 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00132463791760038 0.00557962433456978 1.50864904552129 0.65 1.1 1 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 3.21031777630685e-05 0.000218578095487304 1.50182257925197 0.647058823529412 1.1 1 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00333470438246099 0.0117748990973746 1.50182257925197 0.647058823529412 1.1 1 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000192085907031031 0.00105130094501983 1.4920704845815 0.642857142857143 1.1 1 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000192085907031031 0.00105130094501983 1.4920704845815 0.642857142857143 1.1 1 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.15721056345026e-07 4.99190070198858e-06 1.4889424542155 0.641509433962264 1.1 1 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.87608776947943e-05 0.000196763119998521 1.48286017294828 0.638888888888889 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00116995642201269 0.00508825764701246 1.47699906554532 0.636363636363636 1.1 1 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 6.99007463509933e-05 0.000417935975031359 1.47699906554532 0.636363636363636 1.1 1 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 6.99007463509933e-05 0.000417935975031359 1.47699906554532 0.636363636363636 1.1 1 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00017035601306342 0.000946939869489245 1.46996573666177 0.633333333333333 1.1 1 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00291488717022339 0.0104480716454103 1.4658938094134 0.631578947368421 1.1 1 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00291488717022339 0.0104480716454103 1.4658938094134 0.631578947368421 1.1 1 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00291488717022339 0.0104480716454103 1.4658938094134 0.631578947368421 1.1 1 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 6.266780759294e-09 1.48627150341256e-07 1.46254701989419 0.63013698630137 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00102235547939302 0.00450406144636617 1.45062408223201 0.625 1.1 1 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 RELAXIN RECEPTORS%REACTOME%REACT_198713.2 RELAXIN RECEPTORS 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 5.43446564493662e-05 0.000334772494058217 1.4427828709767 0.621621621621622 1.1 1 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 5.43446564493662e-05 0.000334772494058217 1.4427828709767 0.621621621621622 1.1 1 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 5.43446564493662e-05 0.000334772494058217 1.4427828709767 0.621621621621622 1.1 1 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.04992981234344e-06 3.16791979778447e-05 1.43901908957416 0.62 1.1 1 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00252105376267121 0.00917508824624332 1.43680861478218 0.619047619047619 1.1 1 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00252105376267121 0.00917508824624332 1.43680861478218 0.619047619047619 1.1 1 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00252105376267121 0.00917508824624332 1.43680861478218 0.619047619047619 1.1 1 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000130958357146872 0.000745414968879994 1.43355791655869 0.617647058823529 1.1 1 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000130958357146872 0.000745414968879994 1.43355791655869 0.617647058823529 1.1 1 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0186290893453335 0.0477643137629 1.42830678865921 0.615384615384615 1.1 1 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0186290893453335 0.0477643137629 1.42830678865921 0.615384615384615 1.1 1 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0186290893453335 0.0477643137629 1.42830678865921 0.615384615384615 1.1 1 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.73303022439549e-05 0.000125821531087489 1.4242490989187 0.613636363636364 1.1 1 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.73303022439549e-05 0.000125821531087489 1.4242490989187 0.613636363636364 1.1 1 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 8.00881232688072e-09 1.80897459383353e-07 1.42161160058737 0.6125 1.1 1 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.35446238921603e-06 5.05162010047732e-05 1.42101950912524 0.612244897959184 1.1 1 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.51774352627528e-12 1.04145400159174e-10 1.41945364740719 0.611570247933884 1.1 1 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.51774352627528e-12 1.04145400159174e-10 1.41945364740719 0.611570247933884 1.1 1 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00625211720860976 0.020037754026693 1.41838799151574 0.611111111111111 1.1 1 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00625211720860976 0.020037754026693 1.41838799151574 0.611111111111111 1.1 1 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00625211720860976 0.020037754026693 1.41838799151574 0.611111111111111 1.1 1 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 8.63861354948501e-07 1.21710367137794e-05 1.41620249384007 0.610169491525424 1.1 1 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 8.63861354948501e-07 1.21710367137794e-05 1.41620249384007 0.610169491525424 1.1 1 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00216382007976726 0.00816741637535495 1.41278171486944 0.608695652173913 1.1 1 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 4.80368263636482e-06 4.55709359436476e-05 1.40135760396753 0.60377358490566 1.1 1 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000234638159330934 0.00124585858480567 1.39259911894273 0.6 1.1 1 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00184671515290932 0.00703488850942934 1.39259911894273 0.6 1.1 1 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00184671515290932 0.00703488850942934 1.39259911894273 0.6 1.1 1 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00184671515290932 0.00703488850942934 1.39259911894273 0.6 1.1 1 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00184671515290932 0.00703488850942934 1.39259911894273 0.6 1.1 1 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0053002610491579 0.0174589617429437 1.39259911894273 0.6 1.1 1 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 7.29073359937521e-05 0.00043408844819711 1.38154674498287 0.595238095238095 1.1 1 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000201044565477226 0.0010961165389812 1.38005318093424 0.594594594594595 1.1 1 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.73801555789256e-13 6.88199758680069e-11 1.37602055800294 0.592857142857143 1.1 1 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 8.38845272931269e-06 6.45230715341187e-05 1.37540653722739 0.592592592592593 1.1 1 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00447263881028907 0.0149754471224502 1.37149913229208 0.590909090909091 1.1 1 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.53693141485781e-12 1.04145400159174e-10 1.3692221553154 0.589928057553957 1.1 1 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 8.45541843485894e-07 1.2153596396772e-05 1.36529325386542 0.588235294117647 1.1 1 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0130280622164861 0.0359979272506015 1.36529325386542 0.588235294117647 1.1 1 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.26619145867528e-14 4.99586029712995e-12 1.36358663729809 0.5875 1.1 1 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.28071672805278e-06 2.49650761847623e-05 1.36312612171643 0.587301587301587 1.1 1 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 5.33795851224581e-05 0.000333154165040604 1.36232522505267 0.58695652173913 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00132922884709709 0.00557962433456978 1.36058534609347 0.586206896551724 1.1 1 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00132922884709709 0.00557962433456978 1.36058534609347 0.586206896551724 1.1 1 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000146358396086771 0.000829752978611453 1.3586332867734 0.585365853658537 1.1 1 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.95369881266453e-06 2.15512667474544e-05 1.35689144922625 0.584615384615385 1.1 1 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 6.21359988538365e-07 9.02240064989891e-06 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000403786952835803 0.0019813408065012 1.35391581008321 0.583333333333333 1.1 1 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00376187052029121 0.0130246757916652 1.35391581008321 0.583333333333333 1.1 1 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00376187052029121 0.0130246757916652 1.35391581008321 0.583333333333333 1.1 1 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.67105211881906e-06 1.85773997271838e-05 1.35102899598922 0.582089552238806 1.1 1 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.67105211881906e-06 1.85773997271838e-05 1.35102899598922 0.582089552238806 1.1 1 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 4.50303610709642e-06 4.32960836513392e-05 1.34767656671877 0.580645161290323 1.1 1 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.0495001803345e-12 8.58377466018498e-11 1.34373599196228 0.578947368421053 1.1 1 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 4.54167303232331e-07 6.80294813157481e-06 1.34373599196228 0.578947368421053 1.1 1 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000342083105660654 0.00170204286487801 1.34373599196228 0.578947368421053 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 6.90083898413897e-18 1.09109931938108e-15 1.34264040615555 0.57847533632287 1.1 1 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.86798431666016e-10 7.59469052173547e-09 1.33976338001265 0.577235772357724 1.1 1 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 3.87609126154579e-07 5.9629116791474e-06 1.33903761436801 0.576923076923077 1.1 1 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.77914245179239e-09 1.17253788084493e-07 1.33903761436801 0.576923076923077 1.1 1 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 3.29445986733307e-05 0.000223238875772141 1.33903761436801 0.576923076923077 1.1 1 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00315652181807393 0.0111734590724358 1.33903761436801 0.576923076923077 1.1 1 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.2375996716696e-07 2.17420287998252e-06 1.33798738878811 0.576470588235294 1.1 1 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000946755564620326 0.00421010365142101 1.33633248787434 0.575757575757576 1.1 1 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000289296459558747 0.0014702459355432 1.33457415565345 0.575 1.1 1 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000289296459558747 0.0014702459355432 1.33457415565345 0.575 1.1 1 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000289296459558747 0.0014702459355432 1.33457415565345 0.575 1.1 1 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.36522517537906e-10 5.71386889577767e-09 1.33411726617873 0.574803149606299 1.1 1 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.0857901889201e-12 8.58377466018498e-11 1.32837022876089 0.572327044025157 1.1 1 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.74129033285873e-11 1.5003292860223e-09 1.32628487518355 0.571428571428571 1.1 1 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.4544109976333e-08 4.98946692804597e-07 1.32628487518355 0.571428571428571 1.1 1 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.5775607198574e-05 0.000447421946238883 1.32628487518355 0.571428571428571 1.1 1 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00079690235384653 0.00359997476039242 1.32628487518355 0.571428571428571 1.1 1 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00079690235384653 0.00359997476039242 1.32628487518355 0.571428571428571 1.1 1 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00900587076447347 0.0269230128106003 1.32628487518355 0.571428571428571 1.1 1 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00900587076447347 0.0269230128106003 1.32628487518355 0.571428571428571 1.1 1 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.08920067758721e-08 4.30859791914e-07 1.32296916299559 0.57 1.1 1 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.03663842270313e-07 3.49173069338139e-06 1.32242939589523 0.569767441860465 1.1 1 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.000206033037923659 0.00111477191241585 1.31874916566547 0.568181818181818 1.1 1 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.97629729155125e-12 2.47199214833958e-10 1.31572528222827 0.56687898089172 1.1 1 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000173580998436573 0.000961111909631296 1.31186873523591 0.565217391304348 1.1 1 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00747410315996743 0.0231713481408141 1.31186873523591 0.565217391304348 1.1 1 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00747410315996743 0.0231713481408141 1.31186873523591 0.565217391304348 1.1 1 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00747410315996743 0.0231713481408141 1.31186873523591 0.565217391304348 1.1 1 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.89705401377869e-07 5.9629116791474e-06 1.31068152371081 0.564705882352941 1.1 1 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.89705401377869e-07 5.9629116791474e-06 1.31068152371081 0.564705882352941 1.1 1 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0262700978922745 0.0625122898005128 1.30556167400881 0.5625 1.1 1 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0262700978922745 0.0625122898005128 1.30556167400881 0.5625 1.1 1 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0262700978922745 0.0625122898005128 1.30556167400881 0.5625 1.1 1 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 2.79564366493368e-07 4.62581504093097e-06 1.30393175930967 0.561797752808989 1.1 1 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 8.74555817076076e-07 1.22009110558751e-05 1.30202356649117 0.560975609756098 1.1 1 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000471939540661828 0.00228425158626456 1.30202356649117 0.560975609756098 1.1 1 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.06506899538109e-08 4.30859791914e-07 1.3014945036848 0.560747663551402 1.1 1 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.74356238660205e-06 2.93540547077799e-05 1.29975917767988 0.56 1.1 1 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00619934098786816 0.0200037692193569 1.29975917767988 0.56 1.1 1 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00619934098786816 0.0200037692193569 1.29975917767988 0.56 1.1 1 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00619934098786816 0.0200037692193569 1.29975917767988 0.56 1.1 1 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.24554407322096e-25 7.98852304048358e-23 1.29702859117215 0.558823529411765 1.1 1 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000395665595912868 0.00194820810721111 1.29544104087696 0.558139534883721 1.1 1 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000103290107342401 0.000597487084342423 1.29440302722241 0.557692307692308 1.1 1 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.64901023014712e-06 1.85773997271838e-05 1.28944362865068 0.555555555555556 1.1 1 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.64901023014712e-06 1.85773997271838e-05 1.28944362865068 0.555555555555556 1.1 1 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.000331522998863142 0.00166698666919523 1.28944362865068 0.555555555555556 1.1 1 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.000331522998863142 0.00166698666919523 1.28944362865068 0.555555555555556 1.1 1 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.2075709046429e-07 2.14796674663356e-06 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00128829660510994 0.00551097930488208 1.28944362865068 0.555555555555556 1.1 1 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0051405001184846 0.0169719992310988 1.28944362865068 0.555555555555556 1.1 1 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0051405001184846 0.0169719992310988 1.28944362865068 0.555555555555556 1.1 1 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0051405001184846 0.0169719992310988 1.28944362865068 0.555555555555556 1.1 1 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00107481973872917 0.00472058175373955 1.28265708323673 0.552631578947368 1.1 1 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 7.2614071945168e-08 1.37773099170632e-06 1.2820753793441 0.552380952380952 1.1 1 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.44238684832806e-18 1.09109931938108e-15 1.27996242549883 0.551470588235294 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00089644628395753 0.00400978020595041 1.27654919236417 0.55 1.1 1 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0176125887430093 0.0458184895453422 1.27654919236417 0.55 1.1 1 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0176125887430093 0.0458184895453422 1.27654919236417 0.55 1.1 1 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0176125887430093 0.0458184895453422 1.27654919236417 0.55 1.1 1 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0176125887430093 0.0458184895453422 1.27654919236417 0.55 1.1 1 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.1473384460355e-05 8.77775596079845e-05 1.27491468635602 0.549295774647887 1.1 1 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00353378158848641 0.0124162251862127 1.27280564634551 0.548387096774194 1.1 1 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 4.95757408564499e-07 7.34857075403418e-06 1.27044130149161 0.547368421052632 1.1 1 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 3.60665211890813e-05 0.000240951453765552 1.26929607195301 0.546875 1.1 1 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.99548976892553e-12 2.47199214833958e-10 1.26830520850886 0.546448087431694 1.1 1 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000623224665499917 0.00291726545725783 1.26599919903885 0.545454545454545 1.1 1 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0029302490096237 0.0104767445746093 1.26599919903885 0.545454545454545 1.1 1 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0144457491094948 0.0394554721359137 1.26599919903885 0.545454545454545 1.1 1 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.2927985819414e-06 1.7033818352802e-05 1.26365475607766 0.544444444444444 1.1 1 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00243017616524962 0.00898218359259793 1.25997063142438 0.542857142857143 1.1 1 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0118612871886757 0.0329660384169638 1.25720753793441 0.541666666666667 1.1 1 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0118612871886757 0.0329660384169638 1.25720753793441 0.541666666666667 1.1 1 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.39635792220242e-07 7.91651270442685e-06 1.25333920704846 0.54 1.1 1 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000361012917060243 0.00178996996856002 1.25333920704846 0.54 1.1 1 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.89386976678268e-09 9.72101171602062e-08 1.25233733717872 0.539568345323741 1.1 1 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.75084291120515e-09 7.38575370310363e-08 1.24976844007681 0.538461538461538 1.1 1 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0097492966859614 0.0283127534369859 1.24976844007681 0.538461538461538 1.1 1 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.0097492966859614 0.0283127534369859 1.24976844007681 0.538461538461538 1.1 1 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0634937585161931 0.127795782699495 1.24976844007681 0.538461538461538 1.1 1 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0634937585161931 0.127795782699495 1.24976844007681 0.538461538461538 1.1 1 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0634937585161931 0.127795782699495 1.24976844007681 0.538461538461538 1.1 1 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.19021452065307e-08 2.60565425059896e-07 1.24841587682997 0.537878787878788 1.1 1 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.66355374267043e-06 1.85773997271838e-05 1.24784867288775 0.537634408602151 1.1 1 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.6468873898715e-05 0.000292589413972882 1.24710368860543 0.537313432835821 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 3.88370274221615e-05 0.000257046930333655 1.24459341548022 0.536231884057971 1.1 1 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.88370274221615e-05 0.000257046930333655 1.24459341548022 0.536231884057971 1.1 1 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00802114308936341 0.024652454894523 1.24339207048458 0.535714285714286 1.1 1 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00802114308936341 0.024652454894523 1.24339207048458 0.535714285714286 1.1 1 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.29439073115145e-06 4.15708708192415e-05 1.23962421572554 0.534090909090909 1.1 1 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0066052952619423 0.0210275954311944 1.23786588350465 0.533333333333333 1.1 1 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0066052952619423 0.0210275954311944 1.23786588350465 0.533333333333333 1.1 1 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0510147493033876 0.106599101701499 1.23786588350465 0.533333333333333 1.1 1 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0510147493033876 0.106599101701499 1.23786588350465 0.533333333333333 1.1 1 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0510147493033876 0.106599101701499 1.23786588350465 0.533333333333333 1.1 1 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0510147493033876 0.106599101701499 1.23786588350465 0.533333333333333 1.1 1 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.000121161426333602 0.000695212539002884 1.23537018615887 0.532258064516129 1.1 1 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000794442473975419 0.00359997476039242 1.23457368700597 0.531914893617021 1.1 1 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.58297082693242e-05 0.000118037332696519 1.23394858640495 0.531645569620253 1.1 1 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.58297082693242e-05 0.000118037332696519 1.23394858640495 0.531645569620253 1.1 1 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00544394476204805 0.0177677371476935 1.23303046989721 0.53125 1.1 1 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 5.85822307669256e-05 0.00035777903167955 1.22681350954479 0.528571428571429 1.1 1 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00370639449717041 0.0129906388410677 1.22497144721814 0.527777777777778 1.1 1 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.20522654196701e-08 1.4969278678486e-06 1.22446379224623 0.52755905511811 1.1 1 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00306141405252049 0.0108638209394929 1.22157817451117 0.526315789473684 1.1 1 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00306141405252049 0.0108638209394929 1.22157817451117 0.526315789473684 1.1 1 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0333393101040433 0.074476983168059 1.22157817451117 0.526315789473684 1.1 1 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.87218694410833e-09 9.72101171602062e-08 1.22001204864641 0.525641025641026 1.1 1 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.24394175888143e-09 8.54838726460791e-08 1.21925872228108 0.525316455696203 1.1 1 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00253026443692828 0.00918511809629834 1.21852422907489 0.525 1.1 1 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00209249621086264 0.00791920773419559 1.21576113558492 0.523809523809524 1.1 1 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00209249621086264 0.00791920773419559 1.21576113558492 0.523809523809524 1.1 1 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0270799785193987 0.0642246823885072 1.21576113558492 0.523809523809524 1.1 1 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0270799785193987 0.0642246823885072 1.21576113558492 0.523809523809524 1.1 1 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.07294674303657e-06 1.46808001475099e-05 1.21373317706018 0.522935779816514 1.1 1 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00143337851765576 0.00575861758488461 1.21095575560237 0.521739130434783 1.1 1 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0220511810544337 0.0543925739540424 1.21095575560237 0.521739130434783 1.1 1 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 6.67056571974044e-06 5.27345278843925e-05 1.20988221326585 0.521276595744681 1.1 1 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.00118721334120979 0.00513496834207153 1.20885340186001 0.520833333333333 1.1 1 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00098376683986993 0.00435235897457334 1.20691923641703 0.52 1.1 1 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0179950622395505 0.0464736362375325 1.20691923641703 0.52 1.1 1 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0179950622395505 0.0464736362375325 1.20691923641703 0.52 1.1 1 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0179950622395505 0.0464736362375325 1.20691923641703 0.52 1.1 1 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0179950622395505 0.0464736362375325 1.20691923641703 0.52 1.1 1 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.70592876646765e-06 2.91707320809354e-05 1.20513385293121 0.519230769230769 1.1 1 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.18785067426061e-05 0.000275894051364484 1.20456885815721 0.518987341772152 1.1 1 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.97542426039187e-10 1.52892668176693e-08 1.20394041477224 0.518716577540107 1.1 1 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.48944047482117e-05 0.000234220462059931 1.20348072007397 0.518518518518518 1.1 1 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.48944047482117e-05 0.000234220462059931 1.20348072007397 0.518518518518518 1.1 1 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.000676330694937205 0.00311656061738434 1.20348072007397 0.518518518518518 1.1 1 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0147126160663211 0.0399542989739979 1.20348072007397 0.518518518518518 1.1 1 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0147126160663211 0.0399542989739979 1.20348072007397 0.518518518518518 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0147126160663211 0.0399542989739979 1.20348072007397 0.518518518518518 1.1 1 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.74811007933427e-08 3.71277707894428e-07 1.19793472597224 0.516129032258065 1.1 1 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00988157651362854 0.0286384590201495 1.19793472597224 0.516129032258065 1.1 1 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.61721586761972e-11 9.20519271849144e-10 1.1969274938596 0.515695067264574 1.1 1 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.6085403107136e-07 4.36700336722995e-06 1.19620693550209 0.515384615384615 1.1 1 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 8.55207695913031e-09 1.90150086138163e-07 1.1960974027729 0.515337423312883 1.1 1 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00452341841662771 0.0151099164480311 1.19025565721601 0.512820512820513 1.1 1 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.22960328752902e-09 1.65931056099255e-07 1.18780513086292 0.511764705882353 1.1 1 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.15179093459994e-07 4.99190070198858e-06 1.18667594095371 0.511278195488722 1.1 1 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.036213352139e-05 0.000145604603019789 1.18572751069399 0.510869565217391 1.1 1 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00143661928505554 0.00575861758488461 1.18325415335003 0.509803921568627 1.1 1 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.27264715896178e-11 3.67874278350081e-09 1.18159925243626 0.509090909090909 1.1 1 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.000984862677310342 0.00435235897457334 1.18159925243626 0.509090909090909 1.1 1 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.24222339107605e-08 2.67830891742608e-07 1.18109984446819 0.50887573964497 1.1 1 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.000816023975130203 0.00367469024243759 1.18085890202746 0.508771929824561 1.1 1 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.54279906242809e-09 9.16618739242759e-08 1.17952384391324 0.508196721311475 1.1 1 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.00056093505157369 0.00268757770501468 1.17952384391324 0.508196721311475 1.1 1 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000465342104783324 0.00226000619490331 1.17891988905205 0.507936507936508 1.1 1 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000386178950645097 0.00190809946794435 1.17835310064385 0.507692307692308 1.1 1 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.41654460401157e-19 6.94534710215494e-17 1.1768443258671 0.507042253521127 1.1 1 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.000105585796996755 0.000608293883102765 1.17518912990948 0.506329113924051 1.1 1 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 6.07955841936084e-05 0.000368136665138318 1.17415219832426 0.505882352941176 1.1 1 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 5.05215019168396e-09 1.21851012250276e-07 1.1731133882398 0.505434782608696 1.1 1 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.46639057157093e-09 6.74937266027968e-08 1.17258779980421 0.505208333333333 1.1 1 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 6.78945370047713e-06 5.33778597556849e-05 1.17114604804052 0.504587155963303 1.1 1 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.10766645836673e-06 1.50115178119605e-05 1.16949538412503 0.503875968992248 1.1 1 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.69719006260753e-06 2.91707320809354e-05 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 8.01728230750082e-06 6.20032213237699e-05 1.16049926578561 0.5 1.1 1 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00116637853079607 0.00508825764701246 1.16049926578561 0.5 1.1 1 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00301297543743459 0.0107455239284948 1.16049926578561 0.5 1.1 1 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0143192082652091 0.0391850641565241 1.16049926578561 0.5 1.1 1 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0143192082652091 0.0391850641565241 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0214040890432787 0.0541445039235749 1.16049926578561 0.5 1.1 1 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0214040890432787 0.0541445039235749 1.16049926578561 0.5 1.1 1 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0214040890432787 0.0541445039235749 1.16049926578561 0.5 1.1 1 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.0322410749201916 0.0722504718290278 1.16049926578561 0.5 1.1 1 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0322410749201916 0.0722504718290278 1.16049926578561 0.5 1.1 1 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0948531184099409 0.175066131643769 1.16049926578561 0.5 1.1 1 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0948531184099409 0.175066131643769 1.16049926578561 0.5 1.1 1 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000217337316760709 0.00116267293891161 1.16049926578561 0.5 1.1 1 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000217337316760709 0.00116267293891161 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00963679848263036 0.0283127534369859 1.16049926578561 0.5 1.1 1 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00963679848263036 0.0283127534369859 1.16049926578561 0.5 1.1 1 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0490660314650774 0.103591932900304 1.16049926578561 0.5 1.1 1 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0490660314650774 0.103591932900304 1.16049926578561 0.5 1.1 1 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0608367825787413 0.123144724906897 1.16049926578561 0.5 1.1 1 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0608367825787413 0.123144724906897 1.16049926578561 0.5 1.1 1 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0608367825787413 0.123144724906897 1.16049926578561 0.5 1.1 1 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0608367825787413 0.123144724906897 1.16049926578561 0.5 1.1 1 1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.13866368726958e-11 1.6541920099943e-09 1.15157234835649 0.496153846153846 1.1 1 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 6.41927363190546e-11 2.94665367038757e-09 1.15128895415239 0.496031746031746 1.1 1 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 6.41927363190546e-11 2.94665367038757e-09 1.15128895415239 0.496031746031746 1.1 1 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 6.41927363190546e-11 2.94665367038757e-09 1.15128895415239 0.496031746031746 1.1 1 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 4.53892172079602e-06 4.33482255616962e-05 1.15106431240524 0.495934959349593 1.1 1 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 5.44184608141459e-06 4.90110567965377e-05 1.15090836276259 0.495867768595041 1.1 1 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.09624641799668e-30 7.79979326404638e-28 1.15009786391557 0.495518565941101 1.1 1 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.9438764995893e-05 0.000139703851460382 1.1496534782549 0.495327102803738 1.1 1 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.69178205723832e-21 1.05068117349002e-18 1.14745994819251 0.49438202247191 1.1 1 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000175379839171647 0.000967308182718036 1.14651734692072 0.493975903614458 1.1 1 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.000253772860707028 0.00133747696587445 1.14580940166174 0.493670886075949 1.1 1 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.000442608968133327 0.00215696082758125 1.14460201556937 0.493150684931507 1.1 1 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.57911152555721e-06 5.92586576970764e-05 1.14147468765798 0.491803278688525 1.1 1 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.0013584928142407 0.00565930120418866 1.14147468765798 0.491803278688525 1.1 1 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0013584928142407 0.00565930120418866 1.14147468765798 0.491803278688525 1.1 1 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.00248212047486e-10 4.32282441647192e-09 1.13826747908474 0.490421455938697 1.1 1 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.6129885490601e-05 0.000344279426953126 1.1372892804699 0.49 1.1 1 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0042384285086095 0.014360199447027 1.13681560730019 0.489795918367347 1.1 1 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00513440279463064 0.0169719992310988 1.13580779204549 0.48936170212766 1.1 1 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.000202629781406813 0.00110054266771716 1.13351091076734 0.488372093023256 1.1 1 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.3060842447585e-11 7.74399116788058e-10 1.13277402735387 0.488054607508532 1.1 1 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.50512991088302e-05 0.000114534752042061 1.13124298177421 0.487394957983193 1.1 1 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0111473908177767 0.0312874499678427 1.13074287435521 0.487179487179487 1.1 1 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0111473908177767 0.0312874499678427 1.13074287435521 0.487179487179487 1.1 1 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0111473908177767 0.0312874499678427 1.13074287435521 0.487179487179487 1.1 1 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.000510147470994763 0.00246081305500186 1.12995981142283 0.486842105263158 1.1 1 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.04866164042054e-19 4.85874252386405e-17 1.12961145262782 0.486692015209125 1.1 1 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000614095961441006 0.00289357136798196 1.12913442076438 0.486486486486487 1.1 1 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000614095961441006 0.00289357136798196 1.12913442076438 0.486486486486487 1.1 1 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0135645195432629 0.0373352249711086 1.12913442076438 0.486486486486487 1.1 1 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00089065762632373 0.00399812555917561 1.12734214390602 0.485714285714286 1.1 1 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0165252668499343 0.0439541209859001 1.12734214390602 0.485714285714286 1.1 1 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0165252668499343 0.0439541209859001 1.12734214390602 0.485714285714286 1.1 1 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0201587016922304 0.0515932239353307 1.12533262136786 0.484848484848485 1.1 1 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.00155964429013411 0.00618209979069871 1.12423366372981 0.484375 1.1 1 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.60933512830987e-16 2.85621837506534e-14 1.12407103771162 0.484304932735426 1.1 1 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0246271307250323 0.0601104751659021 1.12306380559898 0.483870967741935 1.1 1 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0246271307250323 0.0601104751659021 1.12306380559898 0.483870967741935 1.1 1 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.00227028299416121 0.00852404406514883 1.12181595692609 0.483333333333333 1.1 1 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0301357479632936 0.0693902416695256 1.12048204972404 0.482758620689655 1.1 1 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0301357479632936 0.0693902416695256 1.12048204972404 0.482758620689655 1.1 1 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0301357479632936 0.0693902416695256 1.12048204972404 0.482758620689655 1.1 1 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000334702388694995 0.00167116315478238 1.11954046816965 0.482352941176471 1.1 1 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000334702388694995 0.00167116315478238 1.11954046816965 0.482352941176471 1.1 1 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.10612335425858e-05 0.000320088701899117 1.11829929248431 0.481818181818182 1.1 1 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0369455958251854 0.0817629593456281 1.11751781149725 0.481481481481481 1.1 1 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0369455958251854 0.0817629593456281 1.11751781149725 0.481481481481481 1.1 1 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0369455958251854 0.0817629593456281 1.11751781149725 0.481481481481481 1.1 1 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0369455958251854 0.0817629593456281 1.11751781149725 0.481481481481481 1.1 1 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.25146116840626e-06 1.66432639499263e-05 1.11698054331865 0.48125 1.1 1 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.63341279302075e-05 0.000120432456190079 1.11481031831374 0.480314960629921 1.1 1 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.0590723424023e-07 6.14474462046647e-06 1.11460381459635 0.480225988700565 1.1 1 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0453912404715525 0.0978662654409382 1.11407929515419 0.48 1.1 1 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00708611596325099 0.0224078733682359 1.11214512971121 0.479166666666667 1.1 1 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.8799669748139e-09 5.24547648070622e-08 1.11043851314388 0.47843137254902 1.1 1 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00146809973212266 0.00585183730759258 1.11004277596884 0.478260869565217 1.1 1 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00146809973212266 0.00585183730759258 1.11004277596884 0.478260869565217 1.1 1 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00858473620102299 0.0258268067950438 1.11004277596884 0.478260869565217 1.1 1 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00858473620102299 0.0258268067950438 1.11004277596884 0.478260869565217 1.1 1 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0559053158979323 0.116476229169484 1.11004277596884 0.478260869565217 1.1 1 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.1323572207192e-16 1.34278693756952e-14 1.1065770776784 0.476767676767677 1.1 1 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.90467484059296e-08 1.32775031056267e-06 1.10523739598629 0.476190476190476 1.1 1 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00256813679081634 0.00929887698048767 1.10523739598629 0.476190476190476 1.1 1 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00373526944246464 0.0130246757916652 1.10149082854227 0.474576271186441 1.1 1 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0855845078059697 0.16066854169907 1.09942035706005 0.473684210526316 1.1 1 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00544198981649656 0.0177677371476935 1.09719930583367 0.472727272727273 1.1 1 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00544198981649656 0.0177677371476935 1.09719930583367 0.472727272727273 1.1 1 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00544198981649656 0.0177677371476935 1.09719930583367 0.472727272727273 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00164850735349028 0.00639189635971844 1.09602708435308 0.472222222222222 1.1 1 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.022688633283838 0.0558580020119402 1.09602708435308 0.472222222222222 1.1 1 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.82223538603675e-08 5.65639571032436e-07 1.09575037971173 0.472103004291845 1.1 1 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 9.82136128731735e-16 9.98271222275185e-14 1.09445459212301 0.471544715447154 1.1 1 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0276427046281272 0.06501746890219 1.09223460309234 0.470588235294118 1.1 1 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0337223564248763 0.0750968907552409 1.08796806167401 0.46875 1.1 1 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0337223564248763 0.0750968907552409 1.08796806167401 0.46875 1.1 1 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00416456534193699 0.0141436192877717 1.08562834541234 0.467741935483871 1.1 1 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 3.09154093011099e-07 4.99190070198858e-06 1.08313264806657 0.466666666666667 1.1 1 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.09154093011099e-07 4.99190070198858e-06 1.08313264806657 0.466666666666667 1.1 1 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00501713258473011 0.0167198587074261 1.08313264806657 0.466666666666667 1.1 1 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.041198865434665 0.0889620417504222 1.08313264806657 0.466666666666667 1.1 1 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.133211691378176 0.23060856062183 1.08313264806657 0.466666666666667 1.1 1 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 5.45454503940146e-17 7.05619781006207e-15 1.08123574325384 0.46584938704028 1.1 1 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00604627915480525 0.0196435051079632 1.08046483366246 0.46551724137931 1.1 1 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0170436285482207 0.045080080713974 1.0795342007308 0.465116279069767 1.1 1 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0170436285482207 0.045080080713974 1.0795342007308 0.465116279069767 1.1 1 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.000165155298006498 0.0009252597994616 1.0790607208182 0.464912280701754 1.1 1 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.00264649214497638 0.00955826985355683 1.07877396537817 0.464788732394366 1.1 1 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00117283802404785 0.00508825764701246 1.07760646108664 0.464285714285714 1.1 1 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00117283802404785 0.00508825764701246 1.07760646108664 0.464285714285714 1.1 1 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.00728913038725041 0.0228618899768883 1.07760646108664 0.464285714285714 1.1 1 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0504149017028378 0.105968102102124 1.07760646108664 0.464285714285714 1.1 1 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00140627911298146 0.00571140014254978 1.07558468536227 0.463414634146341 1.1 1 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00879077047440703 0.026390857352492 1.0745363572089 0.462962962962963 1.1 1 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.02189468121656e-27 4.84718710457055e-25 1.07337469628219 0.462462462462462 1.1 1 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0618058799101924 0.124928646466199 1.07123009149441 0.461538461538462 1.1 1 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00552622498848109 0.0179950072279373 1.06839614945342 0.46031746031746 1.1 1 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.000576648613175972 0.00275359388103828 1.06765932452276 0.46 1.1 1 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0128014431561703 0.0354738135115225 1.06765932452276 0.46 1.1 1 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00128963886755146 0.00551097930488208 1.06712576164194 0.459770114942529 1.1 1 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00128963886755146 0.00551097930488208 1.06712576164194 0.459770114942529 1.1 1 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00349094081469535 0.0122960613349294 1.06379099363681 0.458333333333333 1.1 1 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0154582642132153 0.041686402623135 1.06379099363681 0.458333333333333 1.1 1 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0759289044175591 0.148009357515324 1.06379099363681 0.458333333333333 1.1 1 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0759289044175591 0.148009357515324 1.06379099363681 0.458333333333333 1.1 1 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0759289044175591 0.148009357515324 1.06379099363681 0.458333333333333 1.1 1 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.66301022479609e-05 0.000183065871975113 1.06316706930036 0.458064516129032 1.1 1 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00184894469608333 0.00703488850942934 1.0626258337314 0.457831325301205 1.1 1 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00799619359959263 0.024652454894523 1.06215187038005 0.457627118644068 1.1 1 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00140878527760715 0.00571140014254978 1.05734377549356 0.455555555555556 1.1 1 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000898889589387337 0.00400978020595041 1.05499933253237 0.454545454545455 1.1 1 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0139434288150738 0.0383040525170849 1.05101820297565 0.452830188679245 1.1 1 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.46597295564104e-05 0.000286078396676838 1.04962353975514 0.452229299363057 1.1 1 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00152980293431257 0.00608075300426478 1.04819288522571 0.451612903225806 1.1 1 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0548461763720094 0.114437109937492 1.04819288522571 0.451612903225806 1.1 1 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.60838672912693e-37 6.55773431554762e-34 1.04587280505921 0.450613298902518 1.1 1 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0330335959359395 0.0739100739258522 1.04444933920705 0.45 1.1 1 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.11546326117579 0.205637322469524 1.04444933920705 0.45 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.11546326117579 0.205637322469524 1.04444933920705 0.45 1.1 1 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0202274080122622 0.0516761249577183 1.04208097335851 0.448979591836735 1.1 1 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0668917141162175 0.134444786987821 1.04044761760089 0.448275862068966 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00782328382743292 0.0242011584487762 1.03925307383786 0.447761194029851 1.1 1 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0180655554876072 0.046571169309538 1.03155490292054 0.444444444444444 1.1 1 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0293768703293194 0.0679728235424739 1.03155490292054 0.444444444444444 1.1 1 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0816941071781977 0.156461257758513 1.03155490292054 0.444444444444444 1.1 1 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00702414124895317 0.0222613652500231 1.03155490292054 0.444444444444444 1.1 1 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.143044715522251 0.246133772899834 1.03155490292054 0.444444444444444 1.1 1 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.26659388165655e-05 0.000156582405020332 1.02752539158101 0.442708333333333 1.1 1 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0216975988925327 0.0543925739540424 1.02659550434881 0.442307692307692 1.1 1 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0587485841990627 0.119908982842123 1.02396994039907 0.441176470588235 1.1 1 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0999227832322783 0.181316081690118 1.02123935389134 0.44 1.1 1 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.0999227832322783 0.181316081690118 1.02123935389134 0.44 1.1 1 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.122423657338782 0.215605030189463 1.00912979633531 0.434782608695652 1.1 1 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00122663867611143 0.0052894146548684 1.00830264076455 0.434426229508197 1.1 1 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0865391866374049 0.162246722773422 1.00576603034753 0.433333333333333 1.1 1 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.99406570393662e-17 7.05619781006207e-15 1.00296542880114 0.432126696832579 1.1 1 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00632107901272557 0.0202132481687831 1.00224936590575 0.431818181818182 1.1 1 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.024392149771522 0.0597418745694936 1.00043040153932 0.431034482758621 1.1 1 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.024392149771522 0.0597418745694936 1.00043040153932 0.431034482758621 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.024392149771522 0.0597418745694936 1.00043040153932 0.431034482758621 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0134332245419962 0.0370455010140709 0.999318812204275 0.430555555555556 1.1 1 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000220345960407493 0.00117435318973731 0.998569135675989 0.430232558139535 1.1 1 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.105153511284718 0.189890160606794 0.994713656387665 0.428571428571429 1.1 1 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.150270692814044 0.25701345657979 0.994713656387665 0.428571428571429 1.1 1 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.150270692814044 0.25701345657979 0.994713656387665 0.428571428571429 1.1 1 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.150270692814044 0.25701345657979 0.994713656387665 0.428571428571429 1.1 1 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.00143619375782141 0.00575861758488461 0.99218257838159 0.427480916030534 1.1 1 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.00143619375782141 0.00575861758488461 0.99218257838159 0.427480916030534 1.1 1 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.000422009769905391 0.00206364227689131 0.990670104938935 0.426829268292683 1.1 1 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0256193169274443 0.0622106856979582 0.989278062636913 0.426229508196721 1.1 1 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0167406155977205 0.044443835812605 0.985629513406956 0.424657534246575 1.1 1 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 2.14857561355686e-05 0.00015287115490457 0.983011142783105 0.423529411764706 1.1 1 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.127875179001808 0.221639926576825 0.981960917203208 0.423076923076923 1.1 1 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.000326692611730906 0.00165438998751986 0.97858316466246 0.421621621621622 1.1 1 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.184833957497728 0.300936752310374 0.977262539608934 0.421052631578947 1.1 1 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0153918949724692 0.041686402623135 0.974246297202734 0.419753086419753 1.1 1 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.109428582940191 0.195870281162127 0.973321964852447 0.419354838709677 1.1 1 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0678552005896511 0.136188928686987 0.971580780657719 0.418604651162791 1.1 1 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0278455873253837 0.0653865854191765 0.969969535582002 0.417910447761194 1.1 1 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.00698751873397903 0.0221947302644021 0.967082721488008 0.416666666666667 1.1 1 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0589176397289481 0.119942491179246 0.967082721488008 0.416666666666667 1.1 1 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0940555952034483 0.174045659264638 0.967082721488008 0.416666666666667 1.1 1 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.155634195139655 0.263338239814184 0.967082721488008 0.416666666666667 1.1 1 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.155634195139655 0.263338239814184 0.967082721488008 0.416666666666667 1.1 1 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.081129617233669 0.155589548953519 0.962365244797822 0.414634146341463 1.1 1 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.081129617233669 0.155589548953519 0.962365244797822 0.414634146341463 1.1 1 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.081129617233669 0.155589548953519 0.962365244797822 0.414634146341463 1.1 1 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.00962292755034195 0.0283127534369859 0.959643623630408 0.413461538461538 1.1 1 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0128134505586244 0.0354738135115225 0.957112796524214 0.412371134020619 1.1 1 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.112926970168732 0.201624941719078 0.955705277705796 0.411764705882353 1.1 1 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.112926970168732 0.201624941719078 0.955705277705796 0.411764705882353 1.1 1 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.227869071270607 0.343493314002196 0.955705277705796 0.411764705882353 1.1 1 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.227869071270607 0.343493314002196 0.955705277705796 0.411764705882353 1.1 1 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.227869071270607 0.343493314002196 0.955705277705796 0.411764705882353 1.1 1 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.000168114985016487 0.000938147543837102 0.950770482812307 0.409638554216867 1.1 1 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.189571652924599 0.308297670984805 0.949499399279135 0.409090909090909 1.1 1 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00216976046734522 0.00816817234135514 0.948212814727266 0.408536585365854 1.1 1 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.15962466588054 0.269769476897873 0.94559199434383 0.407407407407407 1.1 1 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0473207599206216 0.101872074685393 0.942905653450808 0.40625 1.1 1 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.099389382001885 0.181316081690118 0.93945178658835 0.404761904761905 1.1 1 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0740184678963351 0.146289277522896 0.937326330057607 0.403846153846154 1.1 1 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0740184678963351 0.146289277522896 0.937326330057607 0.403846153846154 1.1 1 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.049513714042509 0.104382244566652 0.928399412628487 0.4 1.1 1 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.162576940071358 0.272250450485422 0.928399412628487 0.4 1.1 1 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.281632453764325 0.40967313401506 0.928399412628487 0.4 1.1 1 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.00765991277664e-08 9.76150692586459e-07 0.927677484624888 0.399688958009331 1.1 1 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.103144135628047 0.186498227444359 0.918728585413607 0.395833333333333 1.1 1 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.164727784868551 0.272250450485422 0.914332754861389 0.393939393939394 1.1 1 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.000620803109264491 0.00291552087288241 0.91331711170131 0.393501805054152 1.1 1 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.078126291912997 0.152084423245136 0.913179750126381 0.39344262295082 1.1 1 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.000248691600536657 0.001315569321798 0.911312306874589 0.392638036809816 1.1 1 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.121524021473658 0.214285851991345 0.908216816701781 0.391304347826087 1.1 1 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.232738221515482 0.350461893350826 0.908216816701781 0.391304347826087 1.1 1 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.281848206746833 0.40967313401506 0.902610540055474 0.388888888888889 1.1 1 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.0320166812918773 0.0722389403471398 0.899125557275337 0.387387387387387 1.1 1 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0807700651881784 0.155528826471959 0.895242290748899 0.385714285714286 1.1 1 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.16726961605612 0.275178035511252 0.892691742912007 0.384615384615385 1.1 1 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.233337609792133 0.350993043059414 0.892691742912007 0.384615384615385 1.1 1 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.349020920805469 0.478081648109626 0.892691742912007 0.384615384615385 1.1 1 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.349020920805469 0.478081648109626 0.892691742912007 0.384615384615385 1.1 1 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.349020920805469 0.478081648109626 0.892691742912007 0.384615384615385 1.1 1 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.349020920805469 0.478081648109626 0.892691742912007 0.384615384615385 1.1 1 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.1967949558732 0.313593753871853 0.887440615012525 0.382352941176471 1.1 1 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.280810562572851 0.409000440676732 0.884189916789036 0.380952380952381 1.1 1 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.124849168116022 0.219063336903946 0.8803787533546 0.379310344827586 1.1 1 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.124849168116022 0.219063336903946 0.8803787533546 0.379310344827586 1.1 1 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.14468099855348 0.248348686298676 0.875848502479705 0.377358490566038 1.1 1 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.279000637340978 0.407168265005575 0.870374449339207 0.375 1.1 1 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.343873842219633 0.478081648109626 0.870374449339207 0.375 1.1 1 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.343873842219633 0.478081648109626 0.870374449339207 0.375 1.1 1 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.343873842219633 0.478081648109626 0.870374449339207 0.375 1.1 1 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.167984770318489 0.275394387284804 0.864685727448101 0.372549019607843 1.1 1 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.19625807866851 0.313088840745841 0.86362736058464 0.372093023255814 1.1 1 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.0566732213279441 0.117559757944117 0.861015584292549 0.370967741935484 1.1 1 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.0566732213279441 0.117559757944117 0.861015584292549 0.370967741935484 1.1 1 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.0566732213279441 0.117559757944117 0.861015584292549 0.370967741935484 1.1 1 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.0499811213233567 0.105211739117066 0.855971089657471 0.368794326241135 1.1 1 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.194590807265621 0.313088840745841 0.852611705475142 0.36734693877551 1.1 1 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.12454756489344 0.219063336903946 0.852012119184371 0.367088607594937 1.1 1 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.192302877729346 0.312382414393676 0.843999466025898 0.363636363636364 1.1 1 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.332947082371852 0.472366598419885 0.843999466025898 0.363636363636364 1.1 1 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.332947082371852 0.472366598419885 0.843999466025898 0.363636363636364 1.1 1 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.164704412494512 0.272250450485422 0.843999466025898 0.363636363636364 1.1 1 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.139715550680904 0.240696402686351 0.836639005566369 0.36046511627907 1.1 1 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.327502481613956 0.466036031336659 0.835559471365639 0.36 1.1 1 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.137024620998996 0.236346709917056 0.830673158667594 0.357894736842105 1.1 1 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.137024620998996 0.236346709917056 0.830673158667594 0.357894736842105 1.1 1 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.137024620998996 0.236346709917056 0.830673158667594 0.357894736842105 1.1 1 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.322157863892382 0.458889529848708 0.828928046989721 0.357142857142857 1.1 1 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.31693788846173 0.451906428137316 0.823580124105916 0.354838709677419 1.1 1 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.255887382377757 0.381256042400713 0.822020313264807 0.354166666666667 1.1 1 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.311853107173518 0.445102278342946 0.819175952319254 0.352941176470588 1.1 1 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.407149171828194 0.543502130873846 0.819175952319254 0.352941176470588 1.1 1 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.407149171828194 0.543502130873846 0.819175952319254 0.352941176470588 1.1 1 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.407149171828194 0.543502130873846 0.819175952319254 0.352941176470588 1.1 1 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.396248417245365 0.531443447445951 0.812349486049927 0.35 1.1 1 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.396248417245365 0.531443447445951 0.812349486049927 0.35 1.1 1 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.087993180363922 0.164755652181396 0.811101637377039 0.349462365591398 1.1 1 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.353810577195722 0.478081648109626 0.795770925110132 0.342857142857143 1.1 1 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.240058230449238 0.360721079122772 0.791249499399279 0.340909090909091 1.1 1 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.327994548183388 0.466269972092868 0.790127159683819 0.340425531914894 1.1 1 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 5.97342820813421e-05 0.00036325591197329 0.78800730632857 0.339512195121951 1.1 1 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.291307369928047 0.422990191232256 0.773666177190406 0.333333333333333 1.1 1 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.379343063600351 0.509731047689612 0.773666177190406 0.333333333333333 1.1 1 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.274490021108788 0.403511673592774 0.773666177190406 0.333333333333333 1.1 1 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.406120030059028 0.543502130873846 0.773666177190406 0.333333333333333 1.1 1 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.427682626350554 0.56403371389883 0.773666177190406 0.333333333333333 1.1 1 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.440087393572384 0.576652266163447 0.773666177190406 0.333333333333333 1.1 1 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.469799654368874 0.600724085958155 0.773666177190406 0.333333333333333 1.1 1 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.488345797655711 0.616606983197939 0.773666177190406 0.333333333333333 1.1 1 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.488345797655711 0.616606983197939 0.773666177190406 0.333333333333333 1.1 1 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.400701194446264 0.536909415910578 0.757877071533459 0.326530612244898 1.1 1 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.40952227303937 0.546157633116236 0.756847347251484 0.326086956521739 1.1 1 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.493068528611645 0.622018188133307 0.74271953010279 0.32 1.1 1 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.530427255396596 0.650127462902115 0.732946904706701 0.315789473684211 1.1 1 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.554014868308474 0.672091353455207 0.725312041116006 0.3125 1.1 1 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.497812730368927 0.626891606473436 0.722088432044379 0.311111111111111 1.1 1 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.423216032177021 0.559179585689788 0.718684824496672 0.309644670050761 1.1 1 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.446471805989138 0.583508940039696 0.716357571472598 0.308641975308642 1.1 1 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.470851232073425 0.600724085958155 0.715821977026638 0.308411214953271 1.1 1 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.544496997959731 0.661673123908367 0.714153394329606 0.307692307692308 1.1 1 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.462661762840054 0.597972469138417 0.712124549459351 0.306818181818182 1.1 1 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.423657946321807 0.559244209291216 0.711852642414884 0.306701030927835 1.1 1 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.522024719402679 0.640380323887942 0.706390857434719 0.304347826086957 1.1 1 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.564716067664297 0.68274508435539 0.706390857434719 0.304347826086957 1.1 1 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.494059242276842 0.62271594487152 0.706390857434719 0.304347826086957 1.1 1 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.486787303042934 0.615731850871196 0.704588839941263 0.303571428571429 1.1 1 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.507472285247257 0.629176214832699 0.703786651508692 0.303225806451613 1.1 1 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.555845455015428 0.672591906876662 0.703332888354915 0.303030303030303 1.1 1 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.555845455015428 0.672591906876662 0.703332888354915 0.303030303030303 1.1 1 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.555845455015428 0.672591906876662 0.703332888354915 0.303030303030303 1.1 1 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.521509762759732 0.640300597417686 0.700678801983764 0.30188679245283 1.1 1 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.521509762759732 0.640300597417686 0.700678801983764 0.30188679245283 1.1 1 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.546830265342509 0.663941525240947 0.700678801983764 0.30188679245283 1.1 1 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.587932471747123 0.698353845823169 0.696299559471366 0.3 1.1 1 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.587932471747123 0.698353845823169 0.696299559471366 0.3 1.1 1 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.58178632364634 0.693520966464072 0.690026590467119 0.297297297297297 1.1 1 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.618767293896738 0.733754882679215 0.673838283359386 0.290322580645161 1.1 1 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.618767293896738 0.733754882679215 0.673838283359386 0.290322580645161 1.1 1 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.640887179268742 0.75809015469611 0.663142437591777 0.285714285714286 1.1 1 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.641518522613324 0.758206692424219 0.663142437591777 0.285714285714286 1.1 1 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.722149938699927 0.822095490215997 0.653802403259498 0.28169014084507 1.1 1 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.694138806091372 0.792744398930998 0.64683565633952 0.278688524590164 1.1 1 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.671135544716173 0.772278741518129 0.644721814325338 0.277777777777778 1.1 1 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.782212933295681 0.872326805705136 0.640766465771195 0.276073619631902 1.1 1 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.75562056882181 0.85049749278335 0.630394662895887 0.271604938271605 1.1 1 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.726128994262497 0.825964475488036 0.628603768967205 0.270833333333333 1.1 1 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.878603644013286 0.954391591931989 0.62035905452134 0.267281105990783 1.1 1 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.846572208168071 0.926670963248589 0.61438196423944 0.264705882352941 1.1 1 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.858992563104735 0.935230617672562 0.609897424354481 0.262773722627737 1.1 1 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.735126586426458 0.835531255978314 0.605477877801187 0.260869565217391 1.1 1 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.759478172959675 0.85049749278335 0.598967362986121 0.258064516129032 1.1 1 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.897679631453122 0.96845952657907 0.592955829233523 0.255474452554745 1.1 1 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.842582115675684 0.923013356894918 0.588422162933548 0.253521126760563 1.1 1 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.774824196236523 0.864764573525155 0.580249632892805 0.25 1.1 1 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.923256836954066 0.994545404228339 0.580249632892805 0.25 1.1 1 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.932419723640196 1 0.558758905748627 0.240740740740741 1.1 1 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.851755384010028 0.928825725336522 0.549710178530025 0.236842105263158 1.1 1 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.847584017833637 0.927065378460619 0.546117301546169 0.235294117647059 1.1 1 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.938509518568787 1 0.541566324033284 0.233333333333333 1.1 1 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999997514 1 0.496939232200387 0.214105793450882 1.1 1 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.944999718006551 1 0.483541360744004 0.208333333333333 1.1 1 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.925324721051481 0.996018969785369 0.464199706314244 0.2 1.1 1 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.939008159979998 1 0.449225522239591 0.193548387096774 1.1 1 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.991116427726639 1 0.440695923716054 0.189873417721519 1.1 1 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.440695923716054 0.189873417721519 1.1 1 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.953838694360448 1 0.414464023494861 0.178571428571429 1.1 1 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.98679374588094 1 0.39506357984191 0.170212765957447 1.1 1 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0973321964852447 0.0419354838709677 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 4.31097025682169e-05 0.000754438780074588 5.99701670644391 0.75 1.3 1 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 4.58179586586031e-05 0.000754438780074588 5.08837781152817 0.636363636363636 1.3 1 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.000709255020706258 0.00731354995989134 4.9975139220366 0.625 1.3 1 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 3.73853154850555e-05 0.000673408910572582 4.56915558586203 0.571428571428571 1.3 1 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 7.22770464313085e-05 0.00108263407443949 4.26454521347123 0.533333333333333 1.3 1 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 6.89317208092235e-06 0.000185075167380236 3.99801113762928 0.5 1.3 1 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000956811949869186 0.00921620145462382 3.99801113762928 0.5 1.3 1 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.00263392253406075 0.0180195757979252 3.99801113762928 0.5 1.3 1 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.00263392253406075 0.0180195757979252 3.99801113762928 0.5 1.3 1 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00263392253406075 0.0180195757979252 3.99801113762928 0.5 1.3 1 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00263392253406075 0.0180195757979252 3.99801113762928 0.5 1.3 1 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00035172606904176 0.00403634029230987 3.99801113762928 0.5 1.3 1 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 8.33951048410747e-05 0.00121350476952339 3.78758949880668 0.473684210526316 1.3 1 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00022236297140785 0.00273780431363432 3.76283401188638 0.470588235294118 1.3 1 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00022236297140785 0.00273780431363432 3.76283401188638 0.470588235294118 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00438878675177137 0.0260218481157111 3.63455557966298 0.454545454545455 1.3 1 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00438878675177137 0.0260218481157111 3.63455557966298 0.454545454545455 1.3 1 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00036129088790131 0.00411293546786852 3.55378767789269 0.444444444444444 1.3 1 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000958536764078936 0.00921620145462382 3.49825974542562 0.4375 1.3 1 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000958536764078936 0.00921620145462382 3.49825974542562 0.4375 1.3 1 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.34905238824618e-09 2.08918846779645e-07 3.46997193077258 0.433962264150943 1.3 1 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000215606336588668 0.00273780431363432 3.42686668939652 0.428571428571429 1.3 1 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00255401074689843 0.0179032378957461 3.42686668939652 0.428571428571429 1.3 1 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00255401074689843 0.0179032378957461 3.42686668939652 0.428571428571429 1.3 1 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00255401074689843 0.0179032378957461 3.42686668939652 0.428571428571429 1.3 1 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.06549766849428e-12 1.91286719704456e-09 3.39557110319199 0.424657534246575 1.3 1 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 4.9407841663115e-05 0.000781192874295697 3.38293250107093 0.423076923076923 1.3 1 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0038591886022801 0.0238766320914982 3.19840891010342 0.4 1.3 1 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0038591886022801 0.0238766320914982 3.19840891010342 0.4 1.3 1 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0038591886022801 0.0238766320914982 3.19840891010342 0.4 1.3 1 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000847882277323478 0.0084800708242849 3.19840891010342 0.4 1.3 1 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00218185593870613 0.0158407193917287 3.1095642181561 0.388888888888889 1.3 1 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000280163791827495 0.00335019391403803 3.07539318279175 0.384615384615385 1.3 1 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.010108961617165 0.0506515928916402 3.07539318279175 0.384615384615385 1.3 1 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.010108961617165 0.0506515928916402 3.07539318279175 0.384615384615385 1.3 1 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.010108961617165 0.0506515928916402 3.07539318279175 0.384615384615385 1.3 1 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.010108961617165 0.0506515928916402 3.07539318279175 0.384615384615385 1.3 1 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00123697516392952 0.0115046775050438 3.04610372390802 0.380952380952381 1.3 1 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00123697516392952 0.0115046775050438 3.04610372390802 0.380952380952381 1.3 1 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.25806214330916e-05 0.000288745553214343 2.99850835322196 0.375 1.3 1 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0055995797052008 0.032129846453632 2.99850835322196 0.375 1.3 1 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00312595703765005 0.0208837411482442 2.94590294351631 0.368421052631579 1.3 1 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000229009495745506 0.00278530352517825 2.93187483426147 0.366666666666667 1.3 1 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00175583453930806 0.0149394814666792 2.90764446373038 0.363636363636364 1.3 1 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 2.48573920531026e-05 0.000478000930967095 2.85572224116377 0.357142857142857 1.3 1 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000561775456805591 0.00605610965935118 2.85572224116377 0.357142857142857 1.3 1 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0143061565450909 0.0633849646485175 2.85572224116377 0.357142857142857 1.3 1 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0143061565450909 0.0633849646485175 2.85572224116377 0.357142857142857 1.3 1 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00784997313406559 0.0410680579771152 2.82212550891478 0.352941176470588 1.3 1 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0043526126778259 0.0260218481157111 2.79860779634049 0.35 1.3 1 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0043526126778259 0.0260218481157111 2.79860779634049 0.35 1.3 1 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0043526126778259 0.0260218481157111 2.79860779634049 0.35 1.3 1 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.96994613239558e-05 0.000400461906628417 2.78122513922037 0.347826086956522 1.3 1 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00243236072206965 0.0173932126005282 2.78122513922037 0.347826086956522 1.3 1 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00136755348912616 0.0123166368039654 2.76785386451258 0.346153846153846 1.3 1 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00136755348912616 0.0123166368039654 2.76785386451258 0.346153846153846 1.3 1 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00136755348912616 0.0123166368039654 2.76785386451258 0.346153846153846 1.3 1 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.11767598591776e-06 0.000142793194665901 2.71293612910558 0.339285714285714 1.3 1 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000336496581226238 0.00389296451288566 2.66534075841952 0.333333333333333 1.3 1 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00104443278370973 0.00990818567479298 2.66534075841952 0.333333333333333 1.3 1 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00329691921630579 0.021466414846721 2.66534075841952 0.333333333333333 1.3 1 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00329691921630579 0.021466414846721 2.66534075841952 0.333333333333333 1.3 1 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00329691921630579 0.021466414846721 2.66534075841952 0.333333333333333 1.3 1 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00329691921630579 0.021466414846721 2.66534075841952 0.333333333333333 1.3 1 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0106840317317454 0.0526068413642687 2.66534075841952 0.333333333333333 1.3 1 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0195296405164963 0.0814975907770505 2.66534075841952 0.333333333333333 1.3 1 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0195296405164963 0.0814975907770505 2.66534075841952 0.333333333333333 1.3 1 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0195296405164963 0.0814975907770505 2.66534075841952 0.333333333333333 1.3 1 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.29305601763258e-06 6.94259300657695e-05 2.66534075841952 0.333333333333333 1.3 1 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.000787699322473326 0.0079496179849613 2.58694838317188 0.323529411764706 1.3 1 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000787699322473326 0.0079496179849613 2.58694838317188 0.323529411764706 1.3 1 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0043819873825023 0.0260218481157111 2.55872712808274 0.32 1.3 1 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.0043819873825023 0.0260218481157111 2.55872712808274 0.32 1.3 1 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0043819873825023 0.0260218481157111 2.55872712808274 0.32 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000336372479941795 0.00389296451288566 2.53532413605759 0.317073170731707 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000336372479941795 0.00389296451288566 2.53532413605759 0.317073170731707 1.3 1 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000589090432266955 0.0062557886948946 2.52505966587112 0.315789473684211 1.3 1 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0141723738982509 0.0633849646485175 2.52505966587112 0.315789473684211 1.3 1 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0141723738982509 0.0633849646485175 2.52505966587112 0.315789473684211 1.3 1 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00103442079043064 0.00987906566968322 2.51303557222412 0.314285714285714 1.3 1 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000144176313777357 0.00197272013947288 2.4987569610183 0.3125 1.3 1 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.0018220971814008 0.0149394814666792 2.4987569610183 0.3125 1.3 1 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00572173577955835 0.0326989157201267 2.4603145462334 0.307692307692308 1.3 1 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 9.90554636331709e-07 3.21389079470957e-05 2.44584210772615 0.305882352941176 1.3 1 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00134150744248058 0.0123166368039654 2.44322902855122 0.305555555555556 1.3 1 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 6.17561761490685e-08 2.77884371921918e-06 2.39880668257757 0.3 1.3 1 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.73364760953169e-06 0.000107465528641477 2.39880668257757 0.3 1.3 1 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0183808429927187 0.0778335601852755 2.39880668257757 0.3 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0017195271629927 0.0149394814666792 2.37719581156335 0.297297297297297 1.3 1 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0017195271629927 0.0149394814666792 2.37719581156335 0.297297297297297 1.3 1 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0017195271629927 0.0149394814666792 2.37719581156335 0.297297297297297 1.3 1 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00735155754606126 0.0390071429635827 2.36919178526179 0.296296296296296 1.3 1 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00735155754606126 0.0390071429635827 2.36919178526179 0.296296296296296 1.3 1 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00735155754606126 0.0390071429635827 2.36919178526179 0.296296296296296 1.3 1 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0333662835088736 0.123311849989838 2.35177125742899 0.294117647058824 1.3 1 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0333662835088736 0.123311849989838 2.35177125742899 0.294117647058824 1.3 1 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0333662835088736 0.123311849989838 2.35177125742899 0.294117647058824 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0130694513188728 0.0592287554992228 2.33217316361708 0.291666666666667 1.3 1 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0130694513188728 0.0592287554992228 2.33217316361708 0.291666666666667 1.3 1 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0130694513188728 0.0592287554992228 2.33217316361708 0.291666666666667 1.3 1 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000223180112706663 0.00273780431363432 2.32611557098431 0.290909090909091 1.3 1 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000384449412869256 0.00434183741676945 2.30654488709381 0.288461538461538 1.3 1 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00930756003303439 0.0478146495559853 2.28457779293101 0.285714285714286 1.3 1 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 8.73768914338395e-05 0.00125593249000357 2.26752870492407 0.283582089552239 1.3 1 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.000149149366965249 0.00200225989803349 2.24888126491647 0.28125 1.3 1 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.26857648681668e-07 8.96717872427817e-06 2.24681617651893 0.28099173553719 1.3 1 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.26857648681668e-07 8.96717872427817e-06 2.24681617651893 0.28099173553719 1.3 1 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0164479095163502 0.0711409581816604 2.23888623707239 0.28 1.3 1 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.40807261040854e-05 0.000621754785206583 2.22674038045175 0.278481012658228 1.3 1 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.40807261040854e-05 0.000621754785206583 2.22674038045175 0.278481012658228 1.3 1 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.92545682304225e-05 0.0011747838603322 2.22111729868293 0.277777777777778 1.3 1 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000599093884040762 0.00626846027198533 2.22111729868293 0.277777777777778 1.3 1 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00142041741844087 0.0127122892229016 2.21166573570981 0.276595744680851 1.3 1 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.29055139698589e-10 3.62161626434547e-08 2.20723531556616 0.276041666666667 1.3 1 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0116260331248431 0.0557031822782888 2.20579924834719 0.275862068965517 1.3 1 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0116260331248431 0.0557031822782888 2.20579924834719 0.275862068965517 1.3 1 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.27724718134363e-07 1.521630684763e-05 2.19245772063541 0.274193548387097 1.3 1 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.27724718134363e-07 1.521630684763e-05 2.19245772063541 0.274193548387097 1.3 1 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.27724718134363e-07 1.521630684763e-05 2.19245772063541 0.274193548387097 1.3 1 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0291889192271109 0.111058374492457 2.18073334779779 0.272727272727273 1.3 1 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.17953992874549e-05 0.000801139708544003 2.17175913648998 0.271604938271605 1.3 1 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.17953992874549e-05 0.000801139708544003 2.17175913648998 0.271604938271605 1.3 1 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.77601998037517e-06 0.000107465528641477 2.1671462241355 0.271028037383178 1.3 1 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0203996577351682 0.0846318162015869 2.15277522795423 0.269230769230769 1.3 1 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0203996577351682 0.0846318162015869 2.15277522795423 0.269230769230769 1.3 1 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0143429083744362 0.0633849646485175 2.13227260673561 0.266666666666667 1.3 1 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0143429083744362 0.0633849646485175 2.13227260673561 0.266666666666667 1.3 1 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.03733181734609e-10 4.32212317608349e-08 2.13227260673561 0.266666666666667 1.3 1 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.00299477605612184 0.0201955665780477 2.13227260673561 0.266666666666667 1.3 1 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.06056410831189e-07 1.17707641246698e-05 2.12843758406163 0.266187050359712 1.3 1 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.000106564990135165 0.00150140575210238 2.12552490861303 0.265822784810127 1.3 1 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.96112945843836e-05 0.000554432528862867 2.10421638822593 0.263157894736842 1.3 1 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.96112945843836e-05 0.000554432528862867 2.10421638822593 0.263157894736842 1.3 1 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00718662923278254 0.0390071429635827 2.10421638822593 0.263157894736842 1.3 1 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.052060888143586 0.166852801415142 2.10421638822593 0.263157894736842 1.3 1 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.052060888143586 0.166852801415142 2.10421638822593 0.263157894736842 1.3 1 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.15222227299083e-05 0.000426244567474476 2.0999654460275 0.262626262626263 1.3 1 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.40429693128108e-06 4.44069896269551e-05 2.09126736429839 0.261538461538462 1.3 1 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000574728012264459 0.0061491576049047 2.09126736429839 0.261538461538462 1.3 1 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00364857993658034 0.0231782555792582 2.08591885441527 0.260869565217391 1.3 1 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0358841391464592 0.12670751862385 2.08591885441527 0.260869565217391 1.3 1 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0358841391464592 0.12670751862385 2.08591885441527 0.260869565217391 1.3 1 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.000113467770689412 0.00156761784166051 2.06955870653751 0.258823529411765 1.3 1 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0123245066079628 0.057331199096088 2.05612001363791 0.257142857142857 1.3 1 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0123245066079628 0.057331199096088 2.05612001363791 0.257142857142857 1.3 1 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.20733041980233e-09 1.14535412491915e-07 2.04382632147864 0.255605381165919 1.3 1 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.20733041980233e-09 1.14535412491915e-07 2.04382632147864 0.255605381165919 1.3 1 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9.89360934253168e-05 0.00140786060944226 2.0434279147883 0.255555555555556 1.3 1 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.004412521371371 0.0260540162301284 2.04153760219367 0.25531914893617 1.3 1 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00315145072710984 0.0209556746947537 2.03820175643845 0.254901960784314 1.3 1 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.62978931567669e-06 0.000197403458112871 2.03177615190996 0.254098360655738 1.3 1 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.32785739953043e-11 5.91942634941474e-09 2.0284027095325 0.253676470588235 1.3 1 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.37864064931495e-05 0.000463672006023997 2.01701462799315 0.252252252252252 1.3 1 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.5555482774236e-06 7.57613583077872e-05 2.01338690384208 0.251798561151079 1.3 1 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 6.23395454945094e-17 4.43545866193434e-14 2.00796971934744 0.251121076233184 1.3 1 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.00378167561449814 0.0238034930935932 1.99900556881464 0.25 1.3 1 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00529922116625988 0.0306536248763732 1.99900556881464 0.25 1.3 1 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.00744576622542329 0.0392419456991753 1.99900556881464 0.25 1.3 1 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0148501405326871 0.0650207691631193 1.99900556881464 0.25 1.3 1 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0148501405326871 0.0650207691631193 1.99900556881464 0.25 1.3 1 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.043489035088988 0.147344992694357 1.99900556881464 0.25 1.3 1 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.043489035088988 0.147344992694357 1.99900556881464 0.25 1.3 1 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.043489035088988 0.147344992694357 1.99900556881464 0.25 1.3 1 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0632875698605418 0.192146684123328 1.99900556881464 0.25 1.3 1 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0301861370574627 0.113337395864827 1.99900556881464 0.25 1.3 1 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0301861370574627 0.113337395864827 1.99900556881464 0.25 1.3 1 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0301861370574627 0.113337395864827 1.99900556881464 0.25 1.3 1 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00632189161355739 0.0355575168620244 1.95820953679801 0.244897959183673 1.3 1 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00888579245666788 0.0459799369666851 1.95458322284098 0.244444444444444 1.3 1 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.00888579245666788 0.0459799369666851 1.95458322284098 0.244444444444444 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.69097055278362e-06 5.23098064480673e-05 1.94903042959427 0.24375 1.3 1 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.33306771321673e-08 2.52965178530247e-06 1.94189112399136 0.242857142857143 1.3 1 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0252267434965261 0.100553658250859 1.93842964248692 0.242424242424242 1.3 1 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.0027402582656807 0.0186573565170509 1.93452151820771 0.241935483870968 1.3 1 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0360916246723871 0.126800437819809 1.93007434230379 0.241379310344828 1.3 1 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000625743511765965 0.00649951107476619 1.92675235548399 0.240963855421687 1.3 1 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0053471837074011 0.0308058397393999 1.92496832552521 0.240740740740741 1.3 1 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 5.69221929331236e-07 1.92857810818654e-05 1.92254087492555 0.240437158469945 1.3 1 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.000146352883794239 0.00198343003465906 1.92212073924484 0.240384615384615 1.3 1 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00749426560178791 0.0393518079385395 1.91904534606205 0.24 1.3 1 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0520283379014 0.166852801415142 1.91904534606205 0.24 1.3 1 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0520283379014 0.166852801415142 1.91904534606205 0.24 1.3 1 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0105317735344097 0.0520372004842535 1.912092283214 0.239130434782609 1.3 1 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0105317735344097 0.0520372004842535 1.912092283214 0.239130434782609 1.3 1 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0757621205619935 0.216484934858869 1.90381482744251 0.238095238095238 1.3 1 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0757621205619935 0.216484934858869 1.90381482744251 0.238095238095238 1.3 1 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.08251231961485e-06 0.000166450289054076 1.89649246272158 0.237179487179487 1.3 1 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 8.34399232046092e-06 0.000212026804857427 1.89379474940334 0.236842105263158 1.3 1 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.000452137978181565 0.00494917186886436 1.89153215113643 0.236559139784946 1.3 1 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.01685387135335e-07 4.38479714829038e-06 1.88996890142475 0.236363636363636 1.3 1 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.78012565813091e-05 0.000764283012530369 1.88882415950989 0.236220472440945 1.3 1 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.4385420855961e-16 6.82348462601084e-14 1.88670188517337 0.235955056179775 1.3 1 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 6.57185070408526e-05 0.000994866335309928 1.88524102424795 0.235772357723577 1.3 1 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.15668368644851e-05 0.000426244567474476 1.88477667916809 0.235714285714286 1.3 1 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 7.11406639885159e-06 0.000187468823806774 1.88441289289533 0.235668789808917 1.3 1 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0298710129518715 0.113049072953492 1.88141700594319 0.235294117647059 1.3 1 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0298710129518715 0.113049072953492 1.88141700594319 0.235294117647059 1.3 1 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.00086409716761863 0.0084800708242849 1.88141700594319 0.235294117647059 1.3 1 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.00086409716761863 0.0084800708242849 1.88141700594319 0.235294117647059 1.3 1 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.00086409716761863 0.0084800708242849 1.88141700594319 0.235294117647059 1.3 1 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0037971840704467 0.0238034930935932 1.87406772076372 0.234375 1.3 1 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0427107991978505 0.145749321962929 1.86573853089366 0.233333333333333 1.3 1 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.00229862534648149 0.0166037759799145 1.8620873791698 0.232876712328767 1.3 1 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 9.67576310961681e-06 0.000233366286525165 1.86070958606646 0.232704402515723 1.3 1 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.5545845301736e-11 3.16024826633863e-09 1.86003726723929 0.232620320855615 1.3 1 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000447603403357582 0.00493751661223131 1.85766174071663 0.232323232323232 1.3 1 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.12523193553209e-05 0.000266097279191517 1.84908015115354 0.23125 1.3 1 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0103451685478461 0.0516007047367245 1.84523590967505 0.230769230769231 1.3 1 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0615169419512695 0.189068268675284 1.84523590967505 0.230769230769231 1.3 1 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0246980319934937 0.0997958406076659 1.84523590967505 0.230769230769231 1.3 1 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000520991227289994 0.00565931691934093 1.83908512330947 0.23 1.3 1 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000319333447842947 0.00378676246900428 1.8339500631327 0.229357798165138 1.3 1 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0145130467174966 0.0639382832167112 1.83242177141342 0.229166666666667 1.3 1 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 5.42474564009839e-05 0.000830044413533334 1.82766223434481 0.228571428571429 1.3 1 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.000439323179692566 0.00488403816173844 1.82766223434481 0.228571428571429 1.3 1 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00371885230688279 0.0235196748119742 1.82766223434481 0.228571428571429 1.3 1 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0350699777945111 0.124761446003973 1.82766223434481 0.228571428571429 1.3 1 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0350699777945111 0.124761446003973 1.82766223434481 0.228571428571429 1.3 1 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.000269410019165261 0.0032489021802726 1.82365420312914 0.228070175438596 1.3 1 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00136606572402261 0.0123166368039654 1.81727778983149 0.227272727272727 1.3 1 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0894601209546059 0.247153744722039 1.81727778983149 0.227272727272727 1.3 1 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0894601209546059 0.247153744722039 1.81727778983149 0.227272727272727 1.3 1 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0894601209546059 0.247153744722039 1.81727778983149 0.227272727272727 1.3 1 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0894601209546059 0.247153744722039 1.81727778983149 0.227272727272727 1.3 1 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00718528070033657 0.0390071429635827 1.80555341699387 0.225806451612903 1.3 1 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0500659257856024 0.161917755438437 1.80555341699387 0.225806451612903 1.3 1 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0500659257856024 0.161917755438437 1.80555341699387 0.225806451612903 1.3 1 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0288214407002562 0.109954182617868 1.79910501193317 0.225 1.3 1 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.000161228882022803 0.00212433980665231 1.79755539521316 0.224806201550388 1.3 1 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.0015809241710734 0.014060344346484 1.79685893826035 0.224719101123595 1.3 1 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.0168841705633738 0.0728065900353968 1.79502540873151 0.224489795918367 1.3 1 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.0100098193194895 0.0506515928916402 1.79221188928209 0.224137931034483 1.3 1 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.0100098193194895 0.0506515928916402 1.79221188928209 0.224137931034483 1.3 1 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.90887081354827e-06 0.000222409178380337 1.79145854254427 0.224043715846995 1.3 1 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 8.35723593909289e-05 0.00121350476952339 1.78931966998793 0.223776223776224 1.3 1 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00360336555971759 0.0230972486102618 1.78858392999204 0.223684210526316 1.3 1 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0719599274226735 0.206449549843678 1.77689383894635 0.222222222222222 1.3 1 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0719599274226735 0.206449549843678 1.77689383894635 0.222222222222222 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0719599274226735 0.206449549843678 1.77689383894635 0.222222222222222 1.3 1 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0719599274226735 0.206449549843678 1.77689383894635 0.222222222222222 1.3 1 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00300875622947724 0.0201955665780477 1.77689383894634 0.222222222222222 1.3 1 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00498684135158314 0.0289643887481747 1.77689383894634 0.222222222222222 1.3 1 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.00182381649954804 0.0149394814666792 1.77689383894634 0.222222222222222 1.3 1 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.00251216212198887 0.0178740334979508 1.76656306081294 0.22093023255814 1.3 1 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000778439273748161 0.0079496179849613 1.76059206060739 0.220183486238532 1.3 1 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0334034453730038 0.123311849989838 1.75522440188602 0.219512195121951 1.3 1 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.04111379875083e-05 0.000718813116952804 1.75060842712761 0.218934911242604 1.3 1 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 4.40642558360694e-07 1.52935209889578e-05 1.74625773827486 0.218390804597701 1.3 1 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00288533598774356 0.0195515862407576 1.74625773827486 0.218390804597701 1.3 1 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0161079911585793 0.0698831445690803 1.74458667823823 0.218181818181818 1.3 1 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.61881442778286e-05 0.000754438780074588 1.74031073049745 0.217647058823529 1.3 1 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00794019908196528 0.041387924152515 1.73826571201273 0.217391304347826 1.3 1 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00240521244834945 0.0172859460303094 1.73826571201273 0.217391304347826 1.3 1 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0273741342583136 0.104713422176291 1.73826571201273 0.217391304347826 1.3 1 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.104342338123536 0.271939829944673 1.73826571201273 0.217391304347826 1.3 1 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.104342338123536 0.271939829944673 1.73826571201273 0.217391304347826 1.3 1 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0472222949665749 0.158484258814708 1.72886968113698 0.216216216216216 1.3 1 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.0033036857705073 0.021466414846721 1.72641390033991 0.215909090909091 1.3 1 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.0224756797611382 0.091904862931321 1.72463225544792 0.215686274509804 1.3 1 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.0224756797611382 0.091904862931321 1.72463225544792 0.215686274509804 1.3 1 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.0224756797611382 0.091904862931321 1.72463225544792 0.215686274509804 1.3 1 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.0109902998536962 0.0538525122509624 1.72222018236338 0.215384615384615 1.3 1 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.14068404994256e-05 0.000266097279191517 1.71343334469826 0.214285714285714 1.3 1 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00909147547516959 0.0468738029027766 1.71343334469826 0.214285714285714 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0833527793404582 0.234247483107184 1.71343334469826 0.214285714285714 1.3 1 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.000179187859948579 0.00231803931551662 1.70237893602279 0.212903225806452 1.3 1 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.0314207799960546 0.11766255245891 1.70128133516139 0.212765957446809 1.3 1 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.0021697882644368 0.0158407193917287 1.69146625053546 0.211538461538462 1.3 1 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.0103709076280416 0.0516007047367245 1.68930048068843 0.211267605633803 1.3 1 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.00356438641811295 0.022950777705768 1.68337311058075 0.210526315789474 1.3 1 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0542119415507082 0.172967696920757 1.68337311058075 0.210526315789474 1.3 1 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0542119415507082 0.172967696920757 1.68337311058075 0.210526315789474 1.3 1 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.00587679235630998 0.0333174323626658 1.67358605761226 0.209302325581395 1.3 1 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00587679235630998 0.0333174323626658 1.67358605761226 0.209302325581395 1.3 1 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0440215426858809 0.14844231100002 1.67358605761226 0.209302325581395 1.3 1 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0440215426858809 0.14844231100002 1.67358605761226 0.209302325581395 1.3 1 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0142945761659161 0.0633849646485175 1.67081062468089 0.208955223880597 1.3 1 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.000217740117793754 0.00273780431363432 1.66788194698645 0.208588957055215 1.3 1 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 9.93754005391574e-07 3.21389079470957e-05 1.66470088324495 0.208191126279863 1.3 1 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.59903482708758e-10 4.6558423263142e-08 1.65771193511458 0.207317073170732 1.3 1 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.17861773956504e-19 4.52317304340105e-16 1.65683344442294 0.207207207207207 1.3 1 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 5.10052900658036e-15 1.45161055527277e-12 1.64834774176265 0.206145966709347 1.3 1 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.076681033811876 0.21693262646978 1.64623988020029 0.205882352941176 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.00261424032649568 0.0180195757979252 1.64204028866917 0.205357142857143 1.3 1 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0110127063000914 0.0538525122509624 1.64020969748893 0.205128205128205 1.3 1 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00622319039581754 0.0351412695763824 1.63359594870874 0.204301075268817 1.3 1 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.0407383919332423 0.141737730369202 1.63184128066501 0.204081632653061 1.3 1 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 9.28885183556984e-06 0.00022789717520717 1.62995838687963 0.203846153846154 1.3 1 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.00354571956823003 0.022934358843597 1.62881935236748 0.203703703703704 1.3 1 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0271899336958866 0.104289152693387 1.62630961530682 0.203389830508475 1.3 1 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0271899336958866 0.104289152693387 1.62630961530682 0.203389830508475 1.3 1 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 0.00017019655671563 0.00222192385510405 1.62486014149639 0.203208556149733 1.3 1 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.95035398955395e-16 3.18408843178382e-13 1.61910405799919 0.202488687782805 1.3 1 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 8.79414412254656e-10 9.62620545106443e-08 1.61136570566047 0.201520912547529 1.3 1 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.0169575997740012 0.0729023096024279 1.59920445505171 0.2 1.3 1 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.108924520463525 0.282808066332552 1.59920445505171 0.2 1.3 1 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.108924520463525 0.282808066332552 1.59920445505171 0.2 1.3 1 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0700801827495195 0.203104073426815 1.59920445505171 0.2 1.3 1 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0700801827495195 0.203104073426815 1.59920445505171 0.2 1.3 1 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.137438372072013 0.330362843679855 1.59920445505171 0.2 1.3 1 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.137438372072013 0.330362843679855 1.59920445505171 0.2 1.3 1 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.137438372072013 0.330362843679855 1.59920445505171 0.2 1.3 1 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 6.24898095678241e-08 2.77884371921918e-06 1.59545045398351 0.199530516431925 1.3 1 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.0156590688938201 0.0683523160610612 1.57946119017453 0.197530864197531 1.3 1 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0190191894301186 0.0800719128966235 1.57816229116945 0.197368421052632 1.3 1 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0344432565989575 0.123457818993241 1.57298798857545 0.19672131147541 1.3 1 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.00117965861382977 0.011116915281323 1.5688398135001 0.19620253164557 1.3 1 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.00428400249989001 0.0260218481157111 1.56019946834313 0.195121951219512 1.3 1 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.0175048211031496 0.0750281940656079 1.56019946834313 0.195121951219512 1.3 1 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0789715130226143 0.222527649566693 1.56019946834313 0.195121951219512 1.3 1 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0789715130226143 0.222527649566693 1.56019946834313 0.195121951219512 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0982443862861583 0.257145392712726 1.55478210907805 0.194444444444444 1.3 1 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0982443862861583 0.257145392712726 1.55478210907805 0.194444444444444 1.3 1 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.123050583186226 0.306656707309982 1.54761721456617 0.193548387096774 1.3 1 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0160843960126875 0.0698831445690803 1.54468612135677 0.193181818181818 1.3 1 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0472082270285151 0.158484258814708 1.54309201803235 0.192982456140351 1.3 1 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.155514903053142 0.361007678702481 1.53769659139588 0.192307692307692 1.3 1 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.155514903053142 0.361007678702481 1.53769659139588 0.192307692307692 1.3 1 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.155514903053142 0.361007678702481 1.53769659139588 0.192307692307692 1.3 1 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.0351731383879514 0.124816398818092 1.52865131732884 0.191176470588235 1.3 1 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0885026518210486 0.246456503994818 1.52305186195401 0.19047619047619 1.3 1 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.110149540927394 0.282808066332552 1.51276097099486 0.189189189189189 1.3 1 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.0240512118022309 0.0977853554130703 1.50513360475455 0.188235294117647 1.3 1 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.0240512118022309 0.0977853554130703 1.50513360475455 0.188235294117647 1.3 1 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.000110600007524291 0.00154297853634378 1.50105833326153 0.187725631768953 1.3 1 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.0477472207457514 0.158491190434033 1.49925417661098 0.1875 1.3 1 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.138022236680589 0.331206817532004 1.49925417661098 0.1875 1.3 1 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.00203405569291677 0.0153960704841519 1.49078381403126 0.186440677966102 1.3 1 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00949362834965784 0.0485950832430327 1.48313316395925 0.185483870967742 1.3 1 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.174504670241885 0.395766424969391 1.48074486578862 0.185185185185185 1.3 1 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.174504670241885 0.395766424969391 1.48074486578862 0.185185185185185 1.3 1 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 0.00205069964870465 0.0154399238100884 1.47752585521082 0.184782608695652 1.3 1 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00419668509994898 0.0258523069144043 1.47697226740445 0.184713375796178 1.3 1 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000596639339922302 0.00626846027198533 1.47566076324514 0.184549356223176 1.3 1 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00660353682434115 0.0369954051221947 1.47444382380654 0.184397163120567 1.3 1 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.153795250037166 0.358771542299816 1.45382223186519 0.181818181818182 1.3 1 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.153795250037166 0.358771542299816 1.45382223186519 0.181818181818182 1.3 1 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0642012503572381 0.192739196747573 1.43212339258362 0.17910447761194 1.3 1 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0642012503572381 0.192739196747573 1.43212339258362 0.17910447761194 1.3 1 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.80622830547233e-07 7.55959670202098e-06 1.43008174440861 0.178849144634526 1.3 1 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.000209375940061739 0.00268416182619688 1.42260519007668 0.177914110429448 1.3 1 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.170319724942586 0.38902884204382 1.41106275445739 0.176470588235294 1.3 1 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.170319724942586 0.38902884204382 1.41106275445739 0.176470588235294 1.3 1 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.150121052827506 0.353094641609159 1.39930389817025 0.175 1.3 1 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0859545864880214 0.240774363331603 1.39613087345784 0.174603174603175 1.3 1 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.0121454196270683 0.057331199096088 1.39285549310955 0.174193548387097 1.3 1 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.132889703318421 0.329446076345145 1.39061256961018 0.173913043478261 1.3 1 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.0256666806709004 0.101101360059212 1.38773940314405 0.173553719008264 1.3 1 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.0417337996051354 0.143976904590407 1.38706508856526 0.173469387755102 1.3 1 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.214869990883785 0.45230768791069 1.37862453021699 0.172413793103448 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.214869990883785 0.45230768791069 1.37862453021699 0.172413793103448 1.3 1 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.214869990883785 0.45230768791069 1.37862453021699 0.172413793103448 1.3 1 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0546382083080655 0.173937741437085 1.36102506812912 0.170212765957447 1.3 1 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.145484948475002 0.343895484518152 1.36102506812912 0.170212765957447 1.3 1 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0492144582115907 0.161917755438437 1.35932378679395 0.17 1.3 1 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.0492144582115907 0.161917755438437 1.35932378679395 0.17 1.3 1 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0036327273850866 0.0231782555792582 1.34834885425929 0.168627450980392 1.3 1 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0131478079548408 0.0593947006975824 1.33987400288116 0.167567567567568 1.3 1 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.180022854627653 0.399645120335648 1.33267037920976 0.166666666666667 1.3 1 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.20540026423628 0.444617185556286 1.33267037920976 0.166666666666667 1.3 1 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.00495265604317903 0.0288837276616548 1.33267037920976 0.166666666666667 1.3 1 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.00495265604317903 0.0288837276616548 1.33267037920976 0.166666666666667 1.3 1 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.00495265604317903 0.0288837276616548 1.33267037920976 0.166666666666667 1.3 1 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.037048868059876 0.129217007963734 1.32265030117059 0.165413533834586 1.3 1 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.152321289253669 0.357089282714945 1.30844000867867 0.163636363636364 1.3 1 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.195841511434041 0.431397013576842 1.30167804480953 0.162790697674419 1.3 1 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.9849027460332e-10 4.7254305063377e-08 1.29567565596507 0.162040025823112 1.3 1 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.257791489156608 0.513179774427092 1.28968101213848 0.161290322580645 1.3 1 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.257791489156608 0.513179774427092 1.28968101213848 0.161290322580645 1.3 1 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.186529453835341 0.4128015751286 1.27936356404137 0.16 1.3 1 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.139835143011948 0.334722339630064 1.27472818880933 0.159420289855072 1.3 1 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.212183007897923 0.448642526357718 1.27209445288204 0.159090909090909 1.3 1 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.133838587198682 0.330362843679855 1.26252983293556 0.157894736842105 1.3 1 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 0.000426424808693583 0.00477797246276354 1.26031874741378 0.157618213660245 1.3 1 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.0689506385367233 0.200774951444099 1.25921610633993 0.15748031496063 1.3 1 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.128057659269572 0.318021028168589 1.25238903106459 0.156626506024096 1.3 1 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.0346870943213046 0.124019435224162 1.24937848050915 0.15625 1.3 1 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.279970980355871 0.542777527311178 1.24937848050915 0.15625 1.3 1 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.229002574114816 0.468204975524975 1.24382568726244 0.155555555555556 1.3 1 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.262178270936687 0.513179774427092 1.2301572731167 0.153846153846154 1.3 1 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.262178270936687 0.513179774427092 1.2301572731167 0.153846153846154 1.3 1 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.1462036102227 0.344449896269706 1.22292105386307 0.152941176470588 1.3 1 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.1462036102227 0.344449896269706 1.22292105386307 0.152941176470588 1.3 1 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.172214310660481 0.392725903958115 1.22161451427561 0.152777777777778 1.3 1 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0638466596463755 0.192486857366085 1.21890583464307 0.152439024390244 1.3 1 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.246253602206476 0.499884273808581 1.21678599840891 0.152173913043478 1.3 1 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.0939853279531013 0.253297578934211 1.21151852655433 0.151515151515152 1.3 1 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.193800736705154 0.428227404241356 1.21151852655433 0.151515151515152 1.3 1 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.302502360769925 0.550763135912548 1.21151852655433 0.151515151515152 1.3 1 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.231857193119808 0.472683074225626 1.20694675852959 0.150943396226415 1.3 1 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.231857193119808 0.472683074225626 1.20694675852959 0.150943396226415 1.3 1 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0952707368082372 0.25627648105505 1.19940334128878 0.15 1.3 1 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.218739385980492 0.454396376696695 1.19940334128878 0.15 1.3 1 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.218739385980492 0.454396376696695 1.19940334128878 0.15 1.3 1 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.281953074132424 0.54513481588375 1.19940334128878 0.15 1.3 1 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0834599254640494 0.234247483107184 1.19195363109444 0.149068322981366 1.3 1 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0921178153892864 0.250637956594559 1.1865065311674 0.148387096774194 1.3 1 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.247764162551546 0.500083017923529 1.1845958926309 0.148148148148148 1.3 1 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.08810777412969 0.245837965855978 1.1845958926309 0.148148148148148 1.3 1 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0707776021745586 0.204708390029262 1.17707942123095 0.147208121827411 1.3 1 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.325292470395329 0.577891617194198 1.17588562871449 0.147058823529412 1.3 1 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.30204168898486 0.550763135912548 1.17014960125735 0.146341463414634 1.3 1 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.30204168898486 0.550763135912548 1.17014960125735 0.146341463414634 1.3 1 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.124212903965032 0.309012171926993 1.16730252193556 0.145985401459854 1.3 1 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.281857227398541 0.54513481588375 1.16608658180854 0.145833333333333 1.3 1 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.159418185387229 0.369310733821402 1.16305778549215 0.145454545454545 1.3 1 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.233549762498629 0.474773302907927 1.15884380800849 0.144927536231884 1.3 1 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.233549762498629 0.474773302907927 1.15884380800849 0.144927536231884 1.3 1 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.113544668929358 0.28597179448934 1.15665731025753 0.144654088050314 1.3 1 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.113544668929358 0.28597179448934 1.15665731025753 0.144654088050314 1.3 1 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.300111562168376 0.550763135912548 1.14228889646551 0.142857142857143 1.3 1 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.300111562168376 0.550763135912548 1.14228889646551 0.142857142857143 1.3 1 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.322378161377728 0.574991625425428 1.14228889646551 0.142857142857143 1.3 1 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.247433717398605 0.500083017923529 1.14228889646551 0.142857142857143 1.3 1 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.247433717398605 0.500083017923529 1.14228889646551 0.142857142857143 1.3 1 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.263130979181409 0.513179774427092 1.14228889646551 0.142857142857143 1.3 1 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.348251056920452 0.608304615086995 1.14228889646551 0.142857142857143 1.3 1 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.0211023884999409 0.0872927291727208 1.13075062478404 0.141414141414141 1.3 1 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.159610752846214 0.369310733821402 1.12620032045895 0.140845070422535 1.3 1 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.144334517028041 0.341743789901668 1.12139336787163 0.140243902439024 1.3 1 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.206796944127528 0.444617185556286 1.12093770213905 0.14018691588785 1.3 1 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.318601672827242 0.569560528182368 1.1194431185362 0.14 1.3 1 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.175954925838889 0.395766424969391 1.11709134727877 0.139705882352941 1.3 1 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.143899163489026 0.34128084940814 1.11572403840817 0.13953488372093 1.3 1 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.342897618125353 0.604405115585814 1.11572403840817 0.13953488372093 1.3 1 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.195107333728707 0.430446102164264 1.11419982524095 0.139344262295082 1.3 1 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.371291507353383 0.626281193891063 1.11055864934147 0.138888888888889 1.3 1 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.184286268344002 0.408472523136316 1.10893739583878 0.138686131386861 1.3 1 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.257340268864745 0.513179774427092 1.10289962417359 0.137931034482759 1.3 1 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.257340268864745 0.513179774427092 1.10289962417359 0.137931034482759 1.3 1 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.363536767108631 0.626281193891063 1.09036667389889 0.136363636363636 1.3 1 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.363536767108631 0.626281193891063 1.09036667389889 0.136363636363636 1.3 1 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.28701169688097 0.550763135912548 1.08587956824499 0.135802469135802 1.3 1 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.28701169688097 0.550763135912548 1.08587956824499 0.135802469135802 1.3 1 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.331617855962145 0.586930608251409 1.08420641020455 0.135593220338983 1.3 1 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.305506887391624 0.550763135912548 1.08054355071062 0.135135135135135 1.3 1 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.305506887391624 0.550763135912548 1.08054355071062 0.135135135135135 1.3 1 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.196457416577084 0.432084859025024 1.07921773040299 0.134969325153374 1.3 1 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.151452494278466 0.355638447785903 1.06613630336781 0.133333333333333 1.3 1 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.384234335261527 0.631297237843841 1.06613630336781 0.133333333333333 1.3 1 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.335712008292062 0.593438742608204 1.05210819411297 0.131578947368421 1.3 1 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.41729321989823 0.670082310662706 1.05210819411297 0.131578947368421 1.3 1 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.304911911710817 0.550763135912548 1.04998272301375 0.131313131313131 1.3 1 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.366458718977974 0.626281193891063 1.0486586590503 0.131147540983607 1.3 1 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.366458718977974 0.626281193891063 1.0486586590503 0.131147540983607 1.3 1 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.366458718977974 0.626281193891063 1.0486586590503 0.131147540983607 1.3 1 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.366458718977974 0.626281193891063 1.0486586590503 0.131147540983607 1.3 1 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.299993155510943 0.550763135912548 1.04620852199645 0.130841121495327 1.3 1 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.404931445219784 0.651829690664878 1.04295942720764 0.130434782608696 1.3 1 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.317834129179368 0.568903101663196 1.03948289578361 0.13 1.3 1 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.286051981633263 0.550763135912548 1.03765174564424 0.129770992366412 1.3 1 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.286051981633263 0.550763135912548 1.03765174564424 0.129770992366412 1.3 1 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.440104241804339 0.690004354518057 1.02513106093058 0.128205128205128 1.3 1 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.440104241804339 0.690004354518057 1.02513106093058 0.128205128205128 1.3 1 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.412898043530453 0.663902729880039 1.01767556230563 0.127272727272727 1.3 1 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.401587039782239 0.647178207938987 1.01536790796934 0.126984126984127 1.3 1 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0119325292921564 0.0569798294722771 1.01412965442304 0.126829268292683 1.3 1 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.381898843153153 0.631297237843841 1.01215471838716 0.126582278481013 1.3 1 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.381898843153153 0.631297237843841 1.01215471838716 0.126582278481013 1.3 1 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.343189974275009 0.604405115585814 1.00790196746957 0.126050420168067 1.3 1 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.336641610042424 0.59434368621634 1.00737288507194 0.125984251968504 1.3 1 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.419168372339136 0.670952299031036 0.999502784407319 0.125 1.3 1 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.44610260446705 0.690004354518057 0.999502784407319 0.125 1.3 1 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.44610260446705 0.690004354518057 0.999502784407319 0.125 1.3 1 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.4318040040409 0.683103689622616 0.999502784407319 0.125 1.3 1 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.466473447578493 0.711633562448994 0.979104768399006 0.122448979591837 1.3 1 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.428528486659859 0.683103689622616 0.975124667714458 0.121951219512195 1.3 1 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.469323123921897 0.711633562448994 0.965037171151894 0.120689655172414 1.3 1 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.469323123921897 0.711633562448994 0.965037171151894 0.120689655172414 1.3 1 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.469323123921897 0.711633562448994 0.965037171151894 0.120689655172414 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.469323123921897 0.711633562448994 0.965037171151894 0.120689655172414 1.3 1 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.471573377491916 0.711633562448994 0.954748928389081 0.119402985074627 1.3 1 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.459535237151766 0.705413853793919 0.951907413721256 0.119047619047619 1.3 1 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.459535237151766 0.705413853793919 0.951907413721256 0.119047619047619 1.3 1 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.506987888813477 0.743620640116748 0.951907413721256 0.119047619047619 1.3 1 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.487860371531864 0.731533518113637 0.948680608928981 0.11864406779661 1.3 1 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.526177458551382 0.766377199097867 0.922617954837525 0.115384615384615 1.3 1 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.526177458551382 0.766377199097867 0.922617954837525 0.115384615384615 1.3 1 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.524317506424906 0.765234678607837 0.917576326669014 0.114754098360656 1.3 1 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.545476863353721 0.783262943039702 0.905210068897195 0.113207547169811 1.3 1 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.564417893101329 0.798376403462416 0.888446919473173 0.111111111111111 1.3 1 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.555987516341494 0.795380765679832 0.888446919473172 0.111111111111111 1.3 1 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.555987516341494 0.795380765679832 0.888446919473172 0.111111111111111 1.3 1 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.572198813978956 0.808578860270164 0.876276413726965 0.10958904109589 1.3 1 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.6210181282486 0.850537821460787 0.841686555290374 0.105263157894737 1.3 1 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.629342827845499 0.86028323153136 0.832918987006099 0.104166666666667 1.3 1 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.629342827845499 0.86028323153136 0.832918987006099 0.104166666666667 1.3 1 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.636064804548489 0.868637444215451 0.827174718130195 0.103448275862069 1.3 1 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.657991975253638 0.885830256183469 0.81119066560594 0.101449275362319 1.3 1 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.734952700065275 0.942196119092691 0.802813481451662 0.100401606425703 1.3 1 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.665763259907598 0.894599734512287 0.799602227525855 0.1 1.3 1 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.687610992753699 0.912136514664718 0.788340224321266 0.0985915492957746 1.3 1 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.687610992753699 0.912136514664718 0.788340224321266 0.0985915492957746 1.3 1 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.700229995588031 0.919213361366945 0.773808607283086 0.0967741935483871 1.3 1 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.715830452992919 0.932189388138918 0.754341724080996 0.0943396226415094 1.3 1 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.788858547492133 0.991648156432249 0.708508302871011 0.0886075949367089 1.3 1 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.788858547492133 0.991648156432249 0.708508302871011 0.0886075949367089 1.3 1 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.90341169992814 1 0.61507863655835 0.0769230769230769 1.3 1 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.959590587552631 1 0.601851138997956 0.0752688172043011 1.3 1 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.962937228872399 1 0.518260703026017 0.0648148148148148 1.3 1 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999982407 1 0.456531918318708 0.0570948782535684 1.3 1 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.995635446499509 1 0.454319447457872 0.0568181818181818 1.3 1 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99993401801823 1 0.453382706329093 0.0567010309278351 1.3 1 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.977090036044911 1 0.444223459736586 0.0555555555555556 1.3 1 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.986822825196971 1 0.412166096662812 0.0515463917525773 1.3 1 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999898052145136 1 0.399801113762928 0.05 1.3 1 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999999999999 1 0.361483827995414 0.0452079566003617 1.3 1 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999998939740967 1 0.221088173509453 0.0276497695852535 1.3 1 3 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0021012421251205 0.00882025824202498 2.43117224638414 1 10.1 10 1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0021012421251205 0.00882025824202498 2.43117224638414 1 10.1 10 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.000178339921825633 0.00114831542424378 2.43117224638414 1 10.1 10 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.000178339921825633 0.00114831542424378 2.43117224638414 1 10.1 10 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 3.5531775402813e-06 3.89292156152455e-05 2.24415899666228 0.923076923076923 10.1 10 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000346496696175257 0.00202907324550366 2.1610419967859 0.888888888888889 10.1 10 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.000346496696175257 0.00202907324550366 2.1610419967859 0.888888888888889 10.1 10 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.00106306725344279 0.00519468422219683 2.12727571558612 0.875 10.1 10 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00321520834672789 0.0124327214059614 2.08386192547212 0.857142857142857 10.1 10 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00321520834672789 0.0124327214059614 2.08386192547212 0.857142857142857 10.1 10 1 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.00321520834672789 0.0124327214059614 2.08386192547212 0.857142857142857 10.1 10 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00321520834672789 0.0124327214059614 2.08386192547212 0.857142857142857 10.1 10 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00954656140952179 0.0276112944832307 2.02597687198678 0.833333333333333 10.1 10 1 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.00954656140952179 0.0276112944832307 2.02597687198678 0.833333333333333 10.1 10 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 2.37257905885447e-05 0.00020712760740797 1.97532745018711 0.8125 10.1 10 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 7.27668215910059e-08 1.11341061423657e-06 1.9636391220795 0.807692307692308 10.1 10 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0012858665023411 0.00603510549505522 1.94493779710731 0.8 10.1 10 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0012858665023411 0.00603510549505522 1.94493779710731 0.8 10.1 10 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 6.66519288379468e-05 0.000524009363184521 1.94493779710731 0.8 10.1 10 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.36825780319322e-08 2.37442787066336e-07 1.89935331748761 0.78125 10.1 10 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000502623547910784 0.00275089734106556 1.87013249721857 0.769230769230769 10.1 10 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 9.86911180135653e-08 1.47828906245583e-06 1.86389872222784 0.766666666666667 10.1 10 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 7.37311716446789e-05 0.000573330367488405 1.85913171782317 0.764705882352941 10.1 10 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.69258318618375e-06 1.97421792945859e-05 1.84769090725195 0.76 10.1 10 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 4.44945576982961e-06 4.69005597071669e-05 1.82337918478811 0.75 10.1 10 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00134255011091133 0.00615765388959461 1.82337918478811 0.75 10.1 10 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00134255011091133 0.00615765388959461 1.82337918478811 0.75 10.1 10 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00134255011091133 0.00615765388959461 1.82337918478811 0.75 10.1 10 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 1.77839939558681e-06 2.05744905684556e-05 1.80086833065492 0.740740740740741 10.1 10 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00350498479087446 0.0130822297572083 1.76812527009756 0.727272727272727 10.1 10 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00350498479087446 0.0130822297572083 1.76812527009756 0.727272727272727 10.1 10 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 7.4603177616198e-05 0.000576958270368749 1.7365516045601 0.714285714285714 10.1 10 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0253749440665065 0.0635713827581669 1.7365516045601 0.714285714285714 10.1 10 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0253749440665065 0.0635713827581669 1.7365516045601 0.714285714285714 10.1 10 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0253749440665065 0.0635713827581669 1.7365516045601 0.714285714285714 10.1 10 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0253749440665065 0.0635713827581669 1.7365516045601 0.714285714285714 10.1 10 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 2.87980395090204e-05 0.00024538688755291 1.72208034118877 0.708333333333333 10.1 10 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000487508356245695 0.00269931669625535 1.71612158568292 0.705882352941177 10.1 10 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000185039358026386 0.00118076684516389 1.7018205724689 0.7 10.1 10 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000185039358026386 0.00118076684516389 1.7018205724689 0.7 10.1 10 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0089031921741347 0.0261761207929621 1.7018205724689 0.7 10.1 10 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0089031921741347 0.0261761207929621 1.7018205724689 0.7 10.1 10 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0089031921741347 0.0261761207929621 1.7018205724689 0.7 10.1 10 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 2.72424763698514e-05 0.000233530384784931 1.68311924749671 0.692307692307692 10.1 10 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00323238487766256 0.0124652674279507 1.68311924749671 0.692307692307692 10.1 10 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.58081463011138e-08 2.71024002246807e-07 1.6714309193891 0.6875 10.1 10 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00119824335019407 0.00576047394366944 1.6714309193891 0.6875 10.1 10 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 4.01583472965257e-12 1.75294738132195e-10 1.66518647012612 0.684931506849315 10.1 10 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000171084587154273 0.00111165921242251 1.65761744071646 0.681818181818182 10.1 10 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 5.7650986531379e-07 7.25994281718162e-06 1.6410412663093 0.675 10.1 10 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.07159539687813e-11 6.69972784035813e-10 1.6318827407236 0.671232876712329 10.1 10 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 2.29229484265774e-05 0.000201354046981603 1.62078149758943 0.666666666666667 10.1 10 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00287572401185003 0.0114626198007355 1.62078149758943 0.666666666666667 10.1 10 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.90248955640288e-08 4.69345754404693e-07 1.60549110610273 0.660377358490566 10.1 10 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.58455314595104e-11 5.36861696830556e-10 1.60026527610095 0.658227848101266 10.1 10 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.58455314595104e-11 5.36861696830556e-10 1.60026527610095 0.658227848101266 10.1 10 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000137690372687708 0.00101519896546429 1.58961262263578 0.653846153846154 10.1 10 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 4.2817787367078e-07 5.44015280565643e-06 1.58554711720705 0.652173913043478 10.1 10 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000943440869192479 0.00472717027063696 1.58026196014969 0.65 10.1 10 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000943440869192479 0.00472717027063696 1.58026196014969 0.65 10.1 10 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.00671467196056379 0.0216666172332931 1.56289644410409 0.642857142857143 10.1 10 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00671467196056379 0.0216666172332931 1.56289644410409 0.642857142857143 10.1 10 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00671467196056379 0.0216666172332931 1.56289644410409 0.642857142857143 10.1 10 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.91343001911252e-09 5.52774788959615e-08 1.56030457603758 0.641791044776119 10.1 10 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000313478481196446 0.0018742852048006 1.55595023768585 0.64 10.1 10 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000313478481196446 0.0018742852048006 1.55595023768585 0.64 10.1 10 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 4.09861765535121e-05 0.000335191547331309 1.54710961133536 0.636363636363636 10.1 10 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000816859199308617 0.00420793641965867 1.54710961133536 0.636363636363636 10.1 10 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0021430208594364 0.00894287003805865 1.53547720824262 0.631578947368421 10.1 10 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0021430208594364 0.00894287003805865 1.53547720824262 0.631578947368421 10.1 10 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.7871059088462e-10 6.83802018670369e-09 1.53073808105668 0.62962962962963 10.1 10 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.7871059088462e-10 6.83802018670369e-09 1.53073808105668 0.62962962962963 10.1 10 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000270781749454283 0.00167531491075411 1.53073808105668 0.62962962962963 10.1 10 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.51146342749904e-07 8.0572282237662e-06 1.52544140949593 0.627450980392157 10.1 10 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.51146342749904e-07 8.0572282237662e-06 1.52544140949593 0.627450980392157 10.1 10 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.20911887457102e-05 0.000117847682090039 1.51948265399009 0.625 10.1 10 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000699802052693214 0.00368821600363868 1.51948265399009 0.625 10.1 10 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.98877628351022e-11 9.24571445964139e-10 1.51621494935785 0.623655913978495 10.1 10 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.12334349839201e-10 5.39556749680685e-09 1.51590740068658 0.623529411764706 10.1 10 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.12334349839201e-10 5.39556749680685e-09 1.51590740068658 0.623529411764706 10.1 10 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.12334349839201e-10 5.39556749680685e-09 1.51590740068658 0.623529411764706 10.1 10 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.12334349839201e-10 5.39556749680685e-09 1.51590740068658 0.623529411764706 10.1 10 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.31376950560657e-09 2.63309014996921e-08 1.50794227940282 0.620253164556962 10.1 10 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00181692573850427 0.00781113391508027 1.50501139061875 0.619047619047619 10.1 10 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00181692573850427 0.00781113391508027 1.50501139061875 0.619047619047619 10.1 10 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00181692573850427 0.00781113391508027 1.50501139061875 0.619047619047619 10.1 10 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.55642869288961e-06 3.89292156152455e-05 1.50008500308809 0.617021276595745 10.1 10 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.55642869288961e-06 3.89292156152455e-05 1.50008500308809 0.617021276595745 10.1 10 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.81709630677332e-08 8.99753048319394e-07 1.49610599777486 0.615384615384615 10.1 10 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 6.82795899936387e-12 2.4290464140237e-10 1.49610599777486 0.615384615384615 10.1 10 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 3.0488208633056e-06 3.44323181625704e-05 1.48847280390866 0.612244897959184 10.1 10 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00474401590766947 0.0167928722303822 1.48571637279031 0.611111111111111 10.1 10 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00474401590766947 0.0167928722303822 1.48571637279031 0.611111111111111 10.1 10 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.00474401590766947 0.0167928722303822 1.48571637279031 0.611111111111111 10.1 10 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00474401590766947 0.0167928722303822 1.48571637279031 0.611111111111111 10.1 10 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00152885408055584 0.00683286188385237 1.47984397605991 0.608695652173913 10.1 10 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00152885408055584 0.00683286188385237 1.47984397605991 0.608695652173913 10.1 10 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000502339478506203 0.00275089734106556 1.47606886387609 0.607142857142857 10.1 10 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000502339478506203 0.00275089734106556 1.47606886387609 0.607142857142857 10.1 10 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 7.56445183993025e-11 2.19677856494301e-09 1.4734377250813 0.606060606060606 10.1 10 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000167251107060018 0.00109173543736883 1.4734377250813 0.606060606060606 10.1 10 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.53274582053254e-09 3.02930180919139e-08 1.47001112572064 0.604651162790698 10.1 10 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.90359939998417e-05 0.00017096546727267 1.47001112572064 0.604651162790698 10.1 10 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.90359939998417e-05 0.00017096546727267 1.47001112572064 0.604651162790698 10.1 10 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 7.61140592526554e-07 9.25729113816484e-06 1.46708670040422 0.603448275862069 10.1 10 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 7.61140592526554e-07 9.25729113816484e-06 1.46708670040422 0.603448275862069 10.1 10 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 9.24193845142765e-09 1.62361461930636e-07 1.45870334783048 0.6 10.1 10 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.75201440526722e-05 0.000386406657068301 1.45870334783048 0.6 10.1 10 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00127928740993837 0.00603510549505522 1.45870334783048 0.6 10.1 10 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.45796789456334e-13 1.84088858629665e-11 1.45870334783048 0.6 10.1 10 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.61190897341801e-05 0.000150904372971962 1.45870334783048 0.6 10.1 10 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.61190897341801e-05 0.000150904372971962 1.45870334783048 0.6 10.1 10 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000141032921535509 0.00101916114554812 1.45870334783048 0.6 10.1 10 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000141032921535509 0.00101916114554812 1.45870334783048 0.6 10.1 10 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.88487713509182e-10 8.80968115935637e-09 1.45870334783048 0.6 10.1 10 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.88487713509182e-10 8.80968115935637e-09 1.45870334783048 0.6 10.1 10 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.01450612059043e-12 1.75294738132195e-10 1.44289084541498 0.59349593495935 10.1 10 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 3.92134544873586e-06 4.19554479214371e-05 1.44069466452394 0.592592592592593 10.1 10 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00106595066260118 0.00519468422219683 1.44069466452394 0.592592592592593 10.1 10 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00106595066260118 0.00519468422219683 1.44069466452394 0.592592592592593 10.1 10 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00106595066260118 0.00519468422219683 1.44069466452394 0.592592592592593 10.1 10 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 3.36387505386138e-05 0.000281576129508515 1.43660178195427 0.590909090909091 10.1 10 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00326146629512021 0.0125096133098546 1.43660178195427 0.590909090909091 10.1 10 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00326146629512021 0.0125096133098546 1.43660178195427 0.590909090909091 10.1 10 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.7136268479109e-10 4.68940577803309e-09 1.43554932643635 0.59047619047619 10.1 10 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 5.24041177038777e-12 1.91207844852867e-10 1.4312546289197 0.588709677419355 10.1 10 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 5.24041177038777e-12 1.91207844852867e-10 1.4312546289197 0.588709677419355 10.1 10 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 5.24041177038777e-12 1.91207844852867e-10 1.4312546289197 0.588709677419355 10.1 10 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000295114327826101 0.00179464824143821 1.43010132140244 0.588235294117647 10.1 10 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0102004788415298 0.0290305627829938 1.43010132140244 0.588235294117647 10.1 10 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0102004788415298 0.0290305627829938 1.43010132140244 0.588235294117647 10.1 10 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0102004788415298 0.0290305627829938 1.43010132140244 0.588235294117647 10.1 10 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.50378526096919e-10 8.45065495993077e-09 1.42597602912916 0.586538461538462 10.1 10 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000885313300268952 0.00446737881660539 1.42516993753553 0.586206896551724 10.1 10 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.03324822650191e-10 2.94062445262444e-09 1.42365942355828 0.585585585585586 10.1 10 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 8.29783760314734e-05 0.000638260697798846 1.42312521739559 0.585365853658537 10.1 10 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000245710433914992 0.00152683819851979 1.41818381039075 0.583333333333333 10.1 10 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000245710433914992 0.00152683819851979 1.41818381039075 0.583333333333333 10.1 10 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00268952691956353 0.0107808360747575 1.41818381039075 0.583333333333333 10.1 10 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000733428711758757 0.0038229635781418 1.41164840112628 0.580645161290323 10.1 10 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.000733428711758757 0.0038229635781418 1.41164840112628 0.580645161290323 10.1 10 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00832038409898993 0.0249787058499212 1.4075207742224 0.578947368421053 10.1 10 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 5.76130232183656e-05 0.000463182666891154 1.40467729791084 0.577777777777778 10.1 10 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.64199126846744e-05 0.000151724258118777 1.40259937291393 0.576923076923077 10.1 10 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.64199126846744e-05 0.000151724258118777 1.40259937291393 0.576923076923077 10.1 10 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00221276189420375 0.00918005882055956 1.40259937291393 0.576923076923077 10.1 10 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.85063639246204e-18 9.74845558647349e-16 1.40081829434515 0.576190476190476 10.1 10 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000606388968327071 0.00325619434690348 1.39976583882723 0.575757575757576 10.1 10 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.31932109028046e-11 2.16987373155606e-09 1.39493489546631 0.573770491803279 10.1 10 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00551386217405388 0.0185929523072954 1.37414083491278 0.565217391304348 10.1 10 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.76579827194485e-09 5.31855532564529e-08 1.37316210212438 0.564814814814815 10.1 10 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.3134946281934e-13 5.20355142795961e-11 1.36753438859108 0.5625 10.1 10 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0212179680152373 0.055194942824108 1.36753438859108 0.5625 10.1 10 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0212179680152373 0.055194942824108 1.36753438859108 0.5625 10.1 10 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0212179680152373 0.055194942824108 1.36753438859108 0.5625 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000279653017924344 0.00171528553666527 1.36382833333744 0.560975609756098 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000279653017924344 0.00171528553666527 1.36382833333744 0.560975609756098 10.1 10 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.41395845536932e-09 9.7519783316336e-08 1.36327415685092 0.560747663551402 10.1 10 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00100067017962831 0.00497885897066811 1.35859625533231 0.558823529411765 10.1 10 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.77720446785382e-07 2.52896195775598e-06 1.35372090991844 0.556818181818182 10.1 10 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.57773710942904e-08 5.72035944575003e-07 1.35065124799119 0.555555555555556 10.1 10 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 1.47169213715003e-07 2.13695705220867e-06 1.35065124799119 0.555555555555556 10.1 10 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000819113414086754 0.00420793641965867 1.35065124799119 0.555555555555556 10.1 10 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0170210575088552 0.0454537822094831 1.35065124799119 0.555555555555556 10.1 10 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0170210575088552 0.0454537822094831 1.35065124799119 0.555555555555556 10.1 10 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00364627593370696 0.0135473907406397 1.35065124799119 0.555555555555556 10.1 10 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000670243992198006 0.00354556580259391 1.34354255721229 0.552631578947368 10.1 10 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000670243992198006 0.00354556580259391 1.34354255721229 0.552631578947368 10.1 10 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.43424782859814e-07 4.56722865429454e-06 1.34133641179815 0.551724137931034 10.1 10 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000104635016494782 0.000796233307337302 1.33476123330894 0.549019607843137 10.1 10 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.03565887014734e-05 0.000181046410763729 1.33322348995259 0.548387096774194 10.1 10 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000448423180796536 0.00252215883902558 1.33135623016274 0.547619047619048 10.1 10 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.59704695593181e-07 2.29555335180906e-06 1.33074691381027 0.547368421052632 10.1 10 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 1.67419630723521e-05 0.00015370202227069 1.32954732224133 0.546875 10.1 10 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000366704405646974 0.00212017666241947 1.32609395257317 0.545454545454545 10.1 10 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000366704405646974 0.00212017666241947 1.32609395257317 0.545454545454545 10.1 10 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00196038476650418 0.00832724633652374 1.32609395257317 0.545454545454545 10.1 10 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0109941979495617 0.0310411580996553 1.32609395257317 0.545454545454545 10.1 10 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.19040004578623e-08 3.58268881052162e-07 1.32609395257317 0.545454545454545 10.1 10 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00159455552701665 0.00706869942350369 1.31977921946568 0.542857142857143 10.1 10 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.4633096515517e-15 4.10690802846506e-13 1.31915624131157 0.542600896860987 10.1 10 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000245177345464294 0.00152683819851979 1.31688496679141 0.541666666666667 10.1 10 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00885171292936066 0.0261761207929621 1.31688496679141 0.541666666666667 10.1 10 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00885171292936066 0.0261761207929621 1.31688496679141 0.541666666666667 10.1 10 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00885171292936066 0.0261761207929621 1.31688496679141 0.541666666666667 10.1 10 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.00129728764153169 0.00603510549505522 1.31414716020764 0.540540540540541 10.1 10 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00129728764153169 0.00603510549505522 1.31414716020764 0.540540540540541 10.1 10 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.61373850983133e-05 0.000226789628017682 1.309092748053 0.538461538461538 10.1 10 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00713459506660116 0.0223581240589089 1.309092748053 0.538461538461538 10.1 10 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00713459506660116 0.0223581240589089 1.309092748053 0.538461538461538 10.1 10 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00713459506660116 0.0223581240589089 1.309092748053 0.538461538461538 10.1 10 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00713459506660116 0.0223581240589089 1.309092748053 0.538461538461538 10.1 10 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.64457298189913e-28 2.67740911774749e-25 1.30825412361478 0.538116591928251 10.1 10 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 5.96271819299124e-14 5.30309249289158e-12 1.30820220876861 0.538095238095238 10.1 10 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.14300678985478e-05 0.000189409854780332 1.30630150551984 0.537313432835821 10.1 10 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000134028379125143 0.000993345747370203 1.30562953972482 0.537037037037037 10.1 10 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000859322498775687 0.00437760686019523 1.3045314492793 0.536585365853659 10.1 10 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 9.02581906896289e-17 1.16761277592129e-14 1.30407706702598 0.53639846743295 10.1 10 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.75696933813742e-05 0.000160267138985227 1.30367207414802 0.536231884057971 10.1 10 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0057564801940675 0.0189179476123743 1.30241370342008 0.535714285714286 10.1 10 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0057564801940675 0.0189179476123743 1.30241370342008 0.535714285714286 10.1 10 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0057564801940675 0.0189179476123743 1.30241370342008 0.535714285714286 10.1 10 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0057564801940675 0.0189179476123743 1.30241370342008 0.535714285714286 10.1 10 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.44042011411495e-05 0.000138271693018728 1.30119077975489 0.535211267605634 10.1 10 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.00464898719261239 0.0166218813444408 1.29662519807154 0.533333333333333 10.1 10 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00464898719261239 0.0166218813444408 1.29662519807154 0.533333333333333 10.1 10 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00464898719261239 0.0166218813444408 1.29662519807154 0.533333333333333 10.1 10 1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.0424892834704876 0.0940314935902082 1.29662519807154 0.533333333333333 10.1 10 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0424892834704876 0.0940314935902082 1.29662519807154 0.533333333333333 10.1 10 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0424892834704876 0.0940314935902082 1.29662519807154 0.533333333333333 10.1 10 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0424892834704876 0.0940314935902082 1.29662519807154 0.533333333333333 10.1 10 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000464186489774713 0.00259001562917603 1.29317672680008 0.531914893617021 10.1 10 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.902948867867e-05 0.000396414559032656 1.29156025589157 0.53125 10.1 10 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00375788059760731 0.0139256877354042 1.29156025589157 0.53125 10.1 10 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000378237653258305 0.0021690580379378 1.2900097633875 0.530612244897959 10.1 10 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00304006367673956 0.0119173846060617 1.28709118926219 0.529411764705882 10.1 10 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00304006367673956 0.0119173846060617 1.28709118926219 0.529411764705882 10.1 10 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00304006367673956 0.0119173846060617 1.28709118926219 0.529411764705882 10.1 10 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0336126433356583 0.0780273922783716 1.28709118926219 0.529411764705882 10.1 10 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0336126433356583 0.0780273922783716 1.28709118926219 0.529411764705882 10.1 10 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0336126433356583 0.0780273922783716 1.28709118926219 0.529411764705882 10.1 10 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0336126433356583 0.0780273922783716 1.28709118926219 0.529411764705882 10.1 10 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00246122612382065 0.00992159992690307 1.28311868559163 0.527777777777778 10.1 10 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.47046724663111e-05 0.000139498326130405 1.27956434020218 0.526315789473684 10.1 10 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0266884724087055 0.0658192309143637 1.27956434020218 0.526315789473684 10.1 10 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0266884724087055 0.0658192309143637 1.27956434020218 0.526315789473684 10.1 10 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0266884724087055 0.0658192309143637 1.27956434020218 0.526315789473684 10.1 10 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000111275121201242 0.000837801573911995 1.27536904728348 0.524590163934426 10.1 10 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000111275121201242 0.000837801573911995 1.27536904728348 0.524590163934426 10.1 10 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0212556772084408 0.055194942824108 1.27347117667741 0.523809523809524 10.1 10 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 9.08182060235445e-05 0.000694808103072601 1.27347117667741 0.523809523809524 10.1 10 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.6215384188948e-06 3.93393066418878e-05 1.26961217311172 0.522222222222222 10.1 10 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.07042880870035e-11 6.69972784035813e-10 1.26623554499174 0.520833333333333 10.1 10 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000570820926735435 0.0030885101853404 1.26420956811975 0.52 10.1 10 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0135829932979153 0.0372420028187542 1.26420956811975 0.52 10.1 10 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0135829932979153 0.0372420028187542 1.26420956811975 0.52 10.1 10 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0135829932979153 0.0372420028187542 1.26420956811975 0.52 10.1 10 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000307348552475048 0.00185320758547455 1.25899991330607 0.517857142857143 10.1 10 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00874772088033742 0.0260964503411324 1.25750288606076 0.517241379310345 10.1 10 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000203792802534198 0.001283173265514 1.25610566063181 0.516666666666667 10.1 10 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00703658965707343 0.0223505961652131 1.25479857877891 0.516129032258065 10.1 10 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00703658965707343 0.0223505961652131 1.25479857877891 0.516129032258065 10.1 10 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00703658965707343 0.0223505961652131 1.25479857877891 0.516129032258065 10.1 10 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 8.6807103191785e-10 1.82594162010876e-08 1.25155020967704 0.514792899408284 10.1 10 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 7.33516739861148e-05 0.000573330367488405 1.25031715528327 0.514285714285714 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.98410646077101e-05 0.000478392331105458 1.24935240439185 0.513888888888889 10.1 10 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.98545560522269e-05 0.000327821001516294 1.24757523169712 0.513157894736842 10.1 10 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00298169103093581 0.01181879202513 1.24675499814571 0.512820512820513 10.1 10 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00298169103093581 0.01181879202513 1.24675499814571 0.512820512820513 10.1 10 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.42479791465897e-09 6.41248346389436e-08 1.24597577627187 0.5125 10.1 10 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.67242218164188e-07 3.67531460348215e-06 1.24572462211419 0.512396694214876 10.1 10 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.67242218164188e-07 3.67531460348215e-06 1.24572462211419 0.512396694214876 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.27101888801409e-09 2.58379982520579e-08 1.24418814962012 0.511764705882353 10.1 10 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.20356176677912e-07 1.76563751971824e-06 1.24385556791747 0.511627906976744 10.1 10 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.44782025718837e-05 0.000138271693018728 1.24385556791747 0.511627906976744 10.1 10 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00195209008583484 0.00832724633652374 1.24385556791747 0.511627906976744 10.1 10 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.3422791808096e-26 3.82012654858413e-24 1.24331812600254 0.511406844106464 10.1 10 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.5321290593481e-06 3.89292156152455e-05 1.23989784565591 0.51 10.1 10 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.88550777613274e-21 2.98119729492988e-19 1.23841403160882 0.509389671361502 10.1 10 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.0923339073737e-09 7.46588608999074e-08 1.23795887392567 0.50920245398773 10.1 10 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000556745196249105 0.00302384890939876 1.23768768906829 0.509090909090909 10.1 10 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.10698851647043e-15 4.49557281456725e-13 1.23632991369023 0.508532423208191 10.1 10 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.000368013798747441 0.00212017666241947 1.23618927782244 0.508474576271186 10.1 10 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.000368013798747441 0.00212017666241947 1.23618927782244 0.508474576271186 10.1 10 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000299394406578254 0.00181292868323768 1.23551376455587 0.508196721311475 10.1 10 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000131629051405664 0.000980670890839053 1.23320331338326 0.507246376811594 10.1 10 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 3.87156260067406e-05 0.000320304277951115 1.23059335928086 0.506172839506173 10.1 10 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.77645514796481e-24 1.37755652507913e-21 1.23041034420661 0.50609756097561 10.1 10 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.28937359585885e-11 7.23950805979365e-10 1.22663690613018 0.504545454545455 10.1 10 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.32647926825005e-13 1.11034117571755e-11 1.22452425645084 0.503676470588235 10.1 10 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.13682082087219e-07 1.685100029272e-06 1.22433134709993 0.503597122302158 10.1 10 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.62095151007044e-07 4.68419454439112e-06 1.21558612319207 0.5 10.1 10 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000654867324066028 0.00350329399302992 1.21558612319207 0.5 10.1 10 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00150866358461544 0.00679376038261953 1.21558612319207 0.5 10.1 10 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0315171564673199 0.0745659958928654 1.21558612319207 0.5 10.1 10 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000806141840023162 0.00417141759401076 1.21558612319207 0.5 10.1 10 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000992870621260238 0.00495738559316954 1.21558612319207 0.5 10.1 10 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00186144395765804 0.00797841792694996 1.21558612319207 0.5 10.1 10 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00351188458696666 0.0130822297572083 1.21558612319207 0.5 10.1 10 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00538565290279328 0.0183607898291411 1.21558612319207 0.5 10.1 10 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00667997731142465 0.0216666172332931 1.21558612319207 0.5 10.1 10 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.00667997731142465 0.0216666172332931 1.21558612319207 0.5 10.1 10 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00829537615956909 0.0249562796513041 1.21558612319207 0.5 10.1 10 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0128464545680624 0.0354273349813039 1.21558612319207 0.5 10.1 10 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0200313915292293 0.0525916423359656 1.21558612319207 0.5 10.1 10 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0200313915292293 0.0525916423359656 1.21558612319207 0.5 10.1 10 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0250937792072342 0.063312850730309 1.21558612319207 0.5 10.1 10 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.063760598925738 0.131527293553591 1.21558612319207 0.5 10.1 10 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.063760598925738 0.131527293553591 1.21558612319207 0.5 10.1 10 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.063760598925738 0.131527293553591 1.21558612319207 0.5 10.1 10 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.53320751380305e-09 6.52955102875551e-08 1.2089435760708 0.497267759562842 10.1 10 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 6.46995246472997e-05 0.000513540674165898 1.20128510997805 0.494117647058824 10.1 10 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.000331870664370124 0.00195955168215223 1.19796893300088 0.492753623188406 10.1 10 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.000407689211988571 0.00231132170780772 1.19744304672652 0.492537313432836 10.1 10 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.000407689211988571 0.00231132170780772 1.19744304672652 0.492537313432836 10.1 10 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 5.34463690938302e-42 7.60541832205204e-39 1.1973340793003 0.492492492492492 10.1 10 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.57512572475975e-09 1.52530048829164e-07 1.19565848182827 0.491803278688525 10.1 10 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000757564203072723 0.00393435715683389 1.19565848182827 0.491803278688525 10.1 10 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00141342013823528 0.00638506938637713 1.19348455731585 0.490909090909091 10.1 10 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00141342013823528 0.00638506938637713 1.19348455731585 0.490909090909091 10.1 10 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00141342013823528 0.00638506938637713 1.19348455731585 0.490909090909091 10.1 10 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.32485281472488e-22 5.91408194419187e-20 1.18826958109787 0.48876404494382 10.1 10 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.88225767032028e-07 3.90614539511025e-06 1.18359701468702 0.486842105263158 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00951275048055005 0.0276112944832307 1.18273244418688 0.486486486486487 10.1 10 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00951275048055005 0.0276112944832307 1.18273244418688 0.486486486486487 10.1 10 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00951275048055005 0.0276112944832307 1.18273244418688 0.486486486486487 10.1 10 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.00037954704950563 0.0021690580379378 1.18181984199229 0.486111111111111 10.1 10 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.69258794680926e-08 5.83839183145508e-07 1.18124753214145 0.485875706214689 10.1 10 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 9.52073870580845e-07 1.13848833431642e-05 1.18085509110087 0.485714285714286 10.1 10 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.52073870580845e-07 1.13848833431642e-05 1.18085509110087 0.485714285714286 10.1 10 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000465947997940312 0.00259001562917603 1.18085509110087 0.485714285714286 10.1 10 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000702944281400317 0.00369110594993598 1.17875018006504 0.484848484848485 10.1 10 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0146894905267845 0.0399677725040427 1.17875018006504 0.484848484848485 10.1 10 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0146894905267845 0.0399677725040427 1.17875018006504 0.484848484848485 10.1 10 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.60941236451292e-11 1.0928071903621e-09 1.1781834732477 0.484615384615385 10.1 10 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000863874284783678 0.00437760686019523 1.17759905684232 0.484375 10.1 10 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.2023118345504e-07 3.10286112927249e-06 1.17736014447534 0.484276729559748 10.1 10 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.68610484021183e-07 3.67531460348215e-06 1.17687318933245 0.484076433121019 10.1 10 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 3.27629948949863e-07 4.39827752222317e-06 1.17637366760523 0.483870967741935 10.1 10 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.00106206757330662 0.00519468422219683 1.17637366760523 0.483870967741935 10.1 10 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0182932029221146 0.0483557933332545 1.17637366760523 0.483870967741935 10.1 10 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00130628176963159 0.00605485002666369 1.17506658575233 0.483333333333333 10.1 10 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00160737387701168 0.00710339449375036 1.17366936032338 0.482758620689655 10.1 10 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.60746197977445e-06 1.89042842745376e-05 1.17186000365279 0.482014388489209 10.1 10 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000190119343564313 0.00120239922618674 1.17164927536585 0.481927710843373 10.1 10 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000190119343564313 0.00120239922618674 1.17164927536585 0.481927710843373 10.1 10 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00243735010000927 0.00985326475088975 1.1705644149257 0.481481481481481 10.1 10 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0285186691116327 0.0686667785885843 1.1705644149257 0.481481481481481 10.1 10 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.70484927212434e-07 4.74955001282247e-06 1.169424624843 0.481012658227848 10.1 10 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.000285505982871646 0.00174366958637919 1.169424624843 0.481012658227848 10.1 10 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.000429160726934727 0.00242339569217507 1.16696267826439 0.48 10.1 10 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.10343594337934e-09 4.10025938003946e-08 1.16652659355652 0.479820627802691 10.1 10 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 7.91352609162482e-06 7.87478855131616e-05 1.16617205314361 0.479674796747967 10.1 10 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.34931685826965e-14 1.28005192621181e-12 1.16358243877744 0.478609625668449 10.1 10 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0448495326664238 0.0986412441797852 1.1627345526185 0.478260869565217 10.1 10 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0448495326664238 0.0986412441797852 1.1627345526185 0.478260869565217 10.1 10 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.02804364870719e-06 1.21908842675861e-05 1.15324837328478 0.474358974358974 10.1 10 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000588542028745222 0.0031723307079714 1.15160790618196 0.473684210526316 10.1 10 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0713684102408421 0.144257454222611 1.15160790618196 0.473684210526316 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.57628574302385e-05 0.000297605532884382 1.15046543802107 0.473214285714286 10.1 10 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000159263529125918 0.00104438710574277 1.15023203054734 0.473118279569892 10.1 10 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00335535627263424 0.0125980790922389 1.14928142556341 0.472727272727273 10.1 10 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00335535627263424 0.0125980790922389 1.14928142556341 0.472727272727273 10.1 10 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00335535627263424 0.0125980790922389 1.14928142556341 0.472727272727273 10.1 10 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00335535627263424 0.0125980790922389 1.14928142556341 0.472727272727273 10.1 10 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.20706783009915e-05 0.000117847682090039 1.14858531325235 0.47244094488189 10.1 10 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.00413051804531638 0.0151487813878485 1.14677936150195 0.471698113207547 10.1 10 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00413051804531638 0.0151487813878485 1.14677936150195 0.471698113207547 10.1 10 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00108377723949203 0.00526353246347154 1.14612405900967 0.471428571428571 10.1 10 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0203731477420871 0.0533904037513627 1.14408105712195 0.470588235294118 10.1 10 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0905587816724755 0.170682313006533 1.14408105712195 0.470588235294118 10.1 10 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0905587816724755 0.170682313006533 1.14408105712195 0.470588235294118 10.1 10 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0905587816724755 0.170682313006533 1.14408105712195 0.470588235294118 10.1 10 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.000118365789098726 0.000886497462565718 1.14265095580055 0.47 10.1 10 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.000144534086946875 0.00101916114554812 1.14116248299664 0.469387755102041 10.1 10 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 2.94792591367056e-05 0.000249696343759119 1.13587555773685 0.467213114754098 10.1 10 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.58470727918392e-08 8.73300929481178e-07 1.1345470483126 0.466666666666667 10.1 10 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.00953765248120864 0.0276112944832307 1.1345470483126 0.466666666666667 10.1 10 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0315451367023928 0.0745659958928654 1.1345470483126 0.466666666666667 10.1 10 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.115494246605314 0.209627950152247 1.1345470483126 0.466666666666667 10.1 10 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.115494246605314 0.209627950152247 1.1345470483126 0.466666666666667 10.1 10 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.115494246605314 0.209627950152247 1.1345470483126 0.466666666666667 10.1 10 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.115494246605314 0.209627950152247 1.1345470483126 0.466666666666667 10.1 10 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.55308929950284e-07 4.63857437907572e-06 1.13108013601829 0.46524064171123 10.1 10 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 6.49594668656793e-05 0.000513540674165898 1.13028183384526 0.464912280701754 10.1 10 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.66182900649377e-05 0.000229562586438827 1.12944222469814 0.464566929133858 10.1 10 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 3.71461984396579e-06 4.00447275603282e-05 1.12931872090102 0.464516129032258 10.1 10 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0393456380130616 0.0901135291003046 1.12875854296407 0.464285714285714 10.1 10 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.26876237836999e-06 2.60358779388749e-05 1.12664079710485 0.463414634146341 10.1 10 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.01454947049742 0.0397387649094601 1.12664079710485 0.463414634146341 10.1 10 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.47080881790686e-24 3.48826824646911e-22 1.12375567342468 0.462227912932138 10.1 10 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.24398974677476e-09 2.56550349226157e-08 1.12342977450242 0.462093862815884 10.1 10 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.9020392813119e-27 6.76650474326708e-25 1.12207949833114 0.461538461538462 10.1 10 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.19833063582828e-05 0.000117847682090039 1.12207949833114 0.461538461538462 10.1 10 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00687324871375214 0.0220284525217777 1.12207949833114 0.461538461538462 10.1 10 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0491657444900707 0.107801008334932 1.12207949833114 0.461538461538462 10.1 10 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000525053173569577 0.00286264622984486 1.11997822586236 0.460674157303371 10.1 10 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.00329748076106549 0.0125245701168094 1.11911103404984 0.46031746031746 10.1 10 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00845437042081096 0.0252743048504496 1.11833923333671 0.46 10.1 10 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00845437042081096 0.0252743048504496 1.11833923333671 0.46 10.1 10 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0222654819958184 0.0569852174101611 1.1170250861765 0.459459459459459 10.1 10 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.1758872173446e-05 0.000267413462146827 1.11504892503333 0.458646616541353 10.1 10 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00195503813237697 0.00832724633652374 1.11428727959273 0.458333333333333 10.1 10 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0104037854330266 0.0295500731960018 1.11428727959273 0.458333333333333 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.061565939439584 0.128457964549161 1.11428727959273 0.458333333333333 10.1 10 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.061565939439584 0.128457964549161 1.11428727959273 0.458333333333333 10.1 10 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0049549286923506 0.0174095395783084 1.1125703500402 0.457627118644068 10.1 10 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0275815090507297 0.0668109075365196 1.11139302691846 0.457142857142857 10.1 10 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0275815090507297 0.0668109075365196 1.11139302691846 0.457142857142857 10.1 10 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.5383499568259e-10 4.29229801679069e-09 1.11117995310195 0.457055214723926 10.1 10 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00116392152663285 0.00561444180474083 1.11053547057053 0.45679012345679 10.1 10 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0128086624813166 0.0353917023512885 1.10988298204493 0.456521739130435 10.1 10 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0128086624813166 0.0353917023512885 1.10988298204493 0.456521739130435 10.1 10 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.0128086624813166 0.0353917023512885 1.10988298204493 0.456521739130435 10.1 10 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0128086624813166 0.0353917023512885 1.10988298204493 0.456521739130435 10.1 10 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.9890957525038e-08 3.29125959978245e-07 1.10946352513562 0.456349206349206 10.1 10 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.9890957525038e-08 3.29125959978245e-07 1.10946352513562 0.456349206349206 10.1 10 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.9890957525038e-08 3.29125959978245e-07 1.10946352513562 0.456349206349206 10.1 10 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 8.46528355173979e-08 1.28149983980061e-06 1.10602685887004 0.454935622317597 10.1 10 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000847117208845742 0.00433614312297658 1.10507829381097 0.454545454545455 10.1 10 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0074524700108243 0.0230540539682673 1.10507829381097 0.454545454545455 10.1 10 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.015777224781337 0.0423603601204576 1.10507829381097 0.454545454545455 10.1 10 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0342017298586139 0.0792655726202078 1.10507829381097 0.454545454545455 10.1 10 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0772794545236145 0.154189234346477 1.10507829381097 0.454545454545455 10.1 10 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00437223976930354 0.0159940801843674 1.10162492414281 0.453125 10.1 10 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00153175189103929 0.00683286188385237 1.09699235507577 0.451219512195122 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0239761884948892 0.0612533504995104 1.09402751087286 0.45 10.1 10 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0972742803770105 0.18165525062531 1.09402751087286 0.45 10.1 10 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0972742803770105 0.18165525062531 1.09402751087286 0.45 10.1 10 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0972742803770105 0.18165525062531 1.09402751087286 0.45 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0527734623039137 0.111750947706055 1.08983583458599 0.448275862068966 10.1 10 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00135009698773965 0.00615765388959461 1.08983583458599 0.448275862068966 10.1 10 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00135009698773965 0.00615765388959461 1.08983583458599 0.448275862068966 10.1 10 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.90828874062003e-06 3.31079590232184e-05 1.0889625686929 0.447916666666667 10.1 10 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0295822364158128 0.0708678828614505 1.08762968917185 0.447368421052632 10.1 10 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.122842423680487 0.222115335320626 1.08052099839295 0.444444444444444 10.1 10 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.122842423680487 0.222115335320626 1.08052099839295 0.444444444444444 10.1 10 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00698876940879331 0.0223483570083435 1.08052099839295 0.444444444444444 10.1 10 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0656834047928214 0.134292363534748 1.08052099839295 0.444444444444444 10.1 10 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0656834047928214 0.134292363534748 1.08052099839295 0.444444444444444 10.1 10 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0656834047928214 0.134292363534748 1.08052099839295 0.444444444444444 10.1 10 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0656834047928214 0.134292363534748 1.08052099839295 0.444444444444444 10.1 10 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.001042447793643 0.00516865230088499 1.07773615045895 0.443298969072165 10.1 10 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00175042783216542 0.00759408172308352 1.0774513364657 0.443181818181818 10.1 10 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00500095494271026 0.0175279775455091 1.07666199482726 0.442857142857143 10.1 10 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.91029580438191e-05 0.00017096546727267 1.07423889956509 0.441860465116279 10.1 10 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000661407910718334 0.00352503167397824 1.07060796171045 0.440366972477064 10.1 10 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.22803461496932e-05 0.000118877092319819 1.07024430411476 0.440217391304348 10.1 10 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.00110643401139243 0.00535529115037901 1.06971578840902 0.44 10.1 10 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0818741546769245 0.160699202903812 1.06971578840902 0.44 10.1 10 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0818741546769245 0.160699202903812 1.06971578840902 0.44 10.1 10 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0818741546769245 0.160699202903812 1.06971578840902 0.44 10.1 10 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.50517793339908e-07 4.61839648076564e-06 1.06780898664715 0.43921568627451 10.1 10 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00312869605568566 0.0122311387012107 1.0673439130467 0.439024390243902 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0313536199711695 0.0743603353649571 1.0673439130467 0.439024390243902 10.1 10 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0313536199711695 0.0743603353649571 1.0673439130467 0.439024390243902 10.1 10 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00529720582794633 0.0183607898291411 1.06571934088072 0.438356164383562 10.1 10 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0557786879772297 0.116725107340585 1.06363785779306 0.4375 10.1 10 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 3.80357371032343e-12 1.75294738132195e-10 1.06087516205853 0.436363636363636 10.1 10 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0385391784322561 0.088453630498549 1.05974174842386 0.435897435897436 10.1 10 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.0109823826665244 0.0310411580996553 1.05873630084471 0.435483870967742 10.1 10 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00330057188601793 0.0125245701168094 1.0582749778378 0.435294117647059 10.1 10 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00330057188601793 0.0125245701168094 1.0582749778378 0.435294117647059 10.1 10 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000320892342211214 0.00190262417902732 1.0578383056786 0.435114503816794 10.1 10 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000320892342211214 0.00190262417902732 1.0578383056786 0.435114503816794 10.1 10 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.0023719024117537 0.0097769350220002 1.05703141147137 0.434782608695652 10.1 10 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00781561003627632 0.0237566790119178 1.05703141147137 0.434782608695652 10.1 10 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0268921288830726 0.0660923996556343 1.05703141147137 0.434782608695652 10.1 10 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0268921288830726 0.0660923996556343 1.05703141147137 0.434782608695652 10.1 10 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.102225548259915 0.190401773787773 1.05703141147137 0.434782608695652 10.1 10 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.102225548259915 0.190401773787773 1.05703141147137 0.434782608695652 10.1 10 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.84925317432247e-13 1.46193737058938e-11 1.05592069545231 0.434325744308231 10.1 10 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0690068877639002 0.139682505388378 1.05350797343313 0.433333333333333 10.1 10 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000465576651425638 0.00259001562917603 1.05286987048132 0.433070866141732 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00948973345813049 0.0276112944832307 1.05229843500209 0.432835820895522 10.1 10 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.00676397025045795 0.021727155003164 1.05131772816612 0.432432432432432 10.1 10 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.00676397025045795 0.021727155003164 1.05131772816612 0.432432432432432 10.1 10 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.27091239741631e-14 1.28005192621181e-12 1.05111335069174 0.432348367029549 10.1 10 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00819560105287097 0.0247083480894818 1.04675471719317 0.430555555555556 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00819560105287097 0.0247083480894818 1.04675471719317 0.430555555555556 10.1 10 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00585066901203811 0.0191831843413139 1.04632729591216 0.430379746835443 10.1 10 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00216132862708668 0.00899289659749807 1.04540406594518 0.43 10.1 10 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00155694991533361 0.00692356165474913 1.04517685358571 0.429906542056075 10.1 10 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.35350671329168e-32 1.67452002650703e-29 1.04372468937731 0.429309231762427 10.1 10 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0281201826018084 0.0678220675294464 1.04193096273606 0.428571428571429 10.1 10 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0854367298776409 0.16384968546615 1.04193096273606 0.428571428571429 10.1 10 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.12787118319534 0.22974835061486 1.04193096273606 0.428571428571429 10.1 10 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.12787118319534 0.22974835061486 1.04193096273606 0.428571428571429 10.1 10 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.12787118319534 0.22974835061486 1.04193096273606 0.428571428571429 10.1 10 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.12787118319534 0.22974835061486 1.04193096273606 0.428571428571429 10.1 10 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.01201833870479 0.0338655365879527 1.03682345801677 0.426470588235294 10.1 10 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 4.11739611807478e-06 4.3724288627018e-05 1.0349568599065 0.42570281124498 10.1 10 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00377945955650717 0.0139692751919733 1.03454138144006 0.425531914893617 10.1 10 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0493031275163969 0.107935923778204 1.03324820471326 0.425 10.1 10 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0205567401378774 0.0537725022356609 1.0301577315187 0.423728813559322 10.1 10 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0088888993144235 0.0261761207929621 1.02857287347021 0.423076923076923 10.1 10 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0292105299836775 0.0700954201800558 1.02857287347021 0.423076923076923 10.1 10 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0292105299836775 0.0700954201800558 1.02857287347021 0.423076923076923 10.1 10 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.105860322147284 0.194876116967122 1.02857287347021 0.423076923076923 10.1 10 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.0124813465605453 0.0347572527507944 1.02725587875386 0.422535211267606 10.1 10 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0417913248688927 0.0930658142229019 1.0264949484733 0.422222222222222 10.1 10 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.0107152579676296 0.0303741276652131 1.02365147216174 0.421052631578947 10.1 10 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0249123483746121 0.0629667348793482 1.02365147216174 0.421052631578947 10.1 10 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.16027806981841 0.268009040366154 1.02365147216174 0.421052631578947 10.1 10 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.16027806981841 0.268009040366154 1.02365147216174 0.421052631578947 10.1 10 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.16027806981841 0.268009040366154 1.02365147216174 0.421052631578947 10.1 10 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00920286288666353 0.027001389459221 1.02049205403779 0.419753086419753 10.1 10 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0881807277527319 0.16773250639684 1.01952384525787 0.419354838709677 10.1 10 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00790720324694723 0.0239403196178849 1.01770001011429 0.418604651162791 10.1 10 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.00302339856143976 0.0119173846060617 1.0166720303061 0.418181818181818 10.1 10 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0301744265467776 0.0721650571026294 1.0166720303061 0.418181818181818 10.1 10 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0430821432879762 0.0950478913159536 1.01298843599339 0.416666666666667 10.1 10 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0430821432879762 0.0950478913159536 1.01298843599339 0.416666666666667 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0738081392394673 0.148977279628031 1.01298843599339 0.416666666666667 10.1 10 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.131268125988722 0.235257611186337 1.01298843599339 0.416666666666667 10.1 10 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.131268125988722 0.235257611186337 1.01298843599339 0.416666666666667 10.1 10 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0365254182462112 0.0843760879291534 1.00916583812172 0.415094339622642 10.1 10 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0365254182462112 0.0843760879291534 1.00916583812172 0.415094339622642 10.1 10 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.031022513695184 0.0738211320873693 1.00600230884861 0.413793103448276 10.1 10 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.031022513695184 0.0738211320873693 1.00600230884861 0.413793103448276 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.031022513695184 0.0738211320873693 1.00600230884861 0.413793103448276 10.1 10 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.00444672804290705 0.0161551107900301 1.00369496410354 0.412844036697248 10.1 10 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.00329285692174919 0.0125245701168094 1.00107092498171 0.411764705882353 10.1 10 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00283517958010518 0.0113327543328362 0.999917617464445 0.411290322580645 10.1 10 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.162896226121919 0.271430128538046 0.994570464429876 0.409090909090909 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.162896226121919 0.271430128538046 0.994570464429876 0.409090909090909 10.1 10 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.162896226121919 0.271430128538046 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0534007368646435 0.112911216282894 0.992315202605772 0.408163265306122 10.1 10 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.133481952828477 0.236794598032349 0.990477581860206 0.407407407407407 10.1 10 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.133481952828477 0.236794598032349 0.990477581860206 0.407407407407407 10.1 10 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.110350544441233 0.20287961852697 0.987663725093557 0.40625 10.1 10 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00486344728515659 0.0171304096207372 0.984524298122503 0.40495867768595 10.1 10 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.0170571466618862 0.0454537822094831 0.984045909250724 0.404761904761905 10.1 10 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.0170571466618862 0.0454537822094831 0.984045909250724 0.404761904761905 10.1 10 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0767947824992438 0.154189234346477 0.984045909250724 0.404761904761905 10.1 10 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00203975797924321 0.00861298398950469 0.975565933262426 0.401273885350318 10.1 10 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.164197440196587 0.272764407076393 0.972468898553656 0.4 10.1 10 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.202280596112676 0.319984670354879 0.972468898553656 0.4 10.1 10 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00240540684045447 0.0097769350220002 0.972468898553656 0.4 10.1 10 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0150426596592063 0.0408495283509839 0.972468898553656 0.4 10.1 10 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.11159926208689 0.204910645096316 0.972468898553656 0.4 10.1 10 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.134817331569617 0.236794598032349 0.972468898553656 0.4 10.1 10 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.253578041702157 0.373082031105023 0.972468898553656 0.4 10.1 10 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.253578041702157 0.373082031105023 0.972468898553656 0.4 10.1 10 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.253578041702157 0.373082031105023 0.972468898553656 0.4 10.1 10 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.253578041702157 0.373082031105023 0.972468898553656 0.4 10.1 10 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0470590991229297 0.103341200697421 0.964750891422278 0.396825396825397 10.1 10 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0785049924978654 0.156241404649598 0.962339014193722 0.395833333333333 10.1 10 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0937121923053751 0.176159114465718 0.961161120663497 0.395348837209302 10.1 10 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0937121923053751 0.176159114465718 0.961161120663497 0.395348837209302 10.1 10 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.135488023833393 0.236794598032349 0.957734521302843 0.393939393939394 10.1 10 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.135488023833393 0.236794598032349 0.957734521302843 0.393939393939394 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.164570038267253 0.272940751112239 0.955103382508055 0.392857142857143 10.1 10 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00407753230606056 0.0150319390453994 0.951328270324229 0.391304347826087 10.1 10 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0941814881037501 0.176574779409271 0.951328270324229 0.391304347826087 10.1 10 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0941814881037501 0.176574779409271 0.951328270324229 0.391304347826087 10.1 10 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.201898804747494 0.319984670354879 0.951328270324229 0.391304347826087 10.1 10 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00266273513620734 0.0107035934995001 0.946185955349504 0.389189189189189 10.1 10 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00480185510048689 0.0169554337667316 0.945455873593833 0.388888888888889 10.1 10 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.251313376914538 0.373082031105023 0.945455873593833 0.388888888888889 10.1 10 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.251313376914538 0.373082031105023 0.945455873593833 0.388888888888889 10.1 10 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.251313376914538 0.373082031105023 0.945455873593833 0.388888888888889 10.1 10 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.164272028717125 0.272764407076393 0.941098934084184 0.387096774193548 10.1 10 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.135411447478403 0.236794598032349 0.935066248609285 0.384615384615385 10.1 10 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.200658138977402 0.319984670354879 0.935066248609285 0.384615384615385 10.1 10 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.200658138977402 0.319984670354879 0.935066248609285 0.384615384615385 10.1 10 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.200658138977402 0.319984670354879 0.935066248609285 0.384615384615385 10.1 10 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00086444661118402 0.00437760686019523 0.934332863316258 0.384313725490196 10.1 10 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00658580288082895 0.0214944896775679 0.933925923915859 0.384146341463415 10.1 10 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0076460654913053 0.0235505437102326 0.932713880688255 0.383647798742138 10.1 10 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0076460654913053 0.0235505437102326 0.932713880688255 0.383647798742138 10.1 10 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.16348110783031 0.272086101102376 0.929565858911583 0.382352941176471 10.1 10 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.13486343603499 0.236794598032349 0.926160855765387 0.380952380952381 10.1 10 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.248071004061806 0.373082031105023 0.926160855765387 0.380952380952381 10.1 10 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.248071004061806 0.373082031105023 0.926160855765387 0.380952380952381 10.1 10 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.248071004061806 0.373082031105023 0.926160855765387 0.380952380952381 10.1 10 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.198839245290538 0.31971553225812 0.922168783111226 0.379310344827586 10.1 10 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.198839245290538 0.31971553225812 0.922168783111226 0.379310344827586 10.1 10 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.198839245290538 0.31971553225812 0.922168783111226 0.379310344827586 10.1 10 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.198839245290538 0.31971553225812 0.922168783111226 0.379310344827586 10.1 10 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.133080611482529 0.236794598032349 0.911689592394053 0.375 10.1 10 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.244277212002757 0.369794119872258 0.911689592394053 0.375 10.1 10 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.244277212002757 0.369794119872258 0.911689592394053 0.375 10.1 10 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.312285949843128 0.450235974292574 0.911689592394053 0.375 10.1 10 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0406579986869512 0.0921279174068974 0.911689592394053 0.375 10.1 10 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.00560073549440847 0.0188125413475291 0.907488257866891 0.373271889400922 10.1 10 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.13193648889597 0.236158017231402 0.905730836888209 0.372549019607843 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.240173542594417 0.364357090737586 0.90043416532746 0.37037037037037 10.1 10 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.240173542594417 0.364357090737586 0.90043416532746 0.37037037037037 10.1 10 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.304417306053946 0.440229498490615 0.895695038141526 0.368421052631579 10.1 10 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.033082193804184 0.0773004298577237 0.893813325876522 0.367647058823529 10.1 10 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.155537793014956 0.261636321764464 0.893083682345195 0.36734693877551 10.1 10 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.235904563760546 0.364357090737586 0.891429823674185 0.366666666666667 10.1 10 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0325628303435369 0.0768439595005855 0.890288428253347 0.366197183098592 10.1 10 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0376915145493808 0.0866478597799174 0.88728914101611 0.364963503649635 10.1 10 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0376915145493808 0.0866478597799174 0.88728914101611 0.364963503649635 10.1 10 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0373519771147736 0.086145645760653 0.885641318325651 0.364285714285714 10.1 10 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.231560288110811 0.359727390809699 0.884062635048779 0.363636363636364 10.1 10 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.231560288110811 0.359727390809699 0.884062635048779 0.363636363636364 10.1 10 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.231560288110811 0.359727390809699 0.884062635048779 0.363636363636364 10.1 10 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.123218926450552 0.222513365912609 0.880859509559471 0.36231884057971 10.1 10 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.182860128388488 0.301168938306503 0.879360174224051 0.361702127659574 10.1 10 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.147222471467269 0.255995402200601 0.876816220007395 0.360655737704918 10.1 10 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0213219674591448 0.055266228951481 0.876209286767888 0.360406091370558 10.1 10 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.282175489442841 0.412678028239633 0.86827580228005 0.357142857142857 10.1 10 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.387877876900982 0.52717308388739 0.86827580228005 0.357142857142857 10.1 10 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.134283935033344 0.236794598032349 0.861681302515898 0.354430379746835 10.1 10 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.0139229789979484 0.0381007675270781 0.85959304425725 0.353571428571429 10.1 10 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.268694386445631 0.393366370279972 0.858060792841461 0.352941176470588 10.1 10 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.268694386445631 0.393366370279972 0.858060792841461 0.352941176470588 10.1 10 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.37279513121746 0.507643513609996 0.858060792841461 0.352941176470588 10.1 10 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.37279513121746 0.507643513609996 0.858060792841461 0.352941176470588 10.1 10 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.37279513121746 0.507643513609996 0.858060792841461 0.352941176470588 10.1 10 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.37279513121746 0.507643513609996 0.858060792841461 0.352941176470588 10.1 10 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.159619637433723 0.267852292533241 0.856046565628219 0.352112676056338 10.1 10 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 8.72551160698496e-10 1.82594162010876e-08 0.853875130437357 0.351219512195122 10.1 10 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.00651720569716061 0.0213195027748495 0.85216346780475 0.350515463917526 10.1 10 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.256222832641237 0.375881536957196 0.850910286234449 0.35 10.1 10 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.359413996022322 0.491775111865157 0.850910286234449 0.35 10.1 10 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.359413996022322 0.491775111865157 0.850910286234449 0.35 10.1 10 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.359413996022322 0.491775111865157 0.850910286234449 0.35 10.1 10 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.359413996022322 0.491775111865157 0.850910286234449 0.35 10.1 10 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.316514502142495 0.455870583551387 0.835715459694548 0.34375 10.1 10 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.117988641562382 0.213882594832191 0.827633105152048 0.340425531914894 10.1 10 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.309742171277142 0.447021409459811 0.810390748794714 0.333333333333333 10.1 10 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.384305957285757 0.522817760246302 0.810390748794714 0.333333333333333 10.1 10 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.433536008368922 0.579269239351152 0.810390748794714 0.333333333333333 10.1 10 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.433536008368922 0.579269239351152 0.810390748794714 0.333333333333333 10.1 10 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.371102723983177 0.507280668806975 0.810390748794714 0.333333333333333 10.1 10 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.455027794500394 0.595680360233727 0.810390748794714 0.333333333333333 10.1 10 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.455027794500394 0.595680360233727 0.810390748794714 0.333333333333333 10.1 10 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.455027794500394 0.595680360233727 0.810390748794714 0.333333333333333 10.1 10 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.150308280428727 0.257688136471926 0.80541902640947 0.331288343558282 10.1 10 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.30851328353434 0.445699900984128 0.797105654552177 0.327868852459016 10.1 10 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.237736159841136 0.364357090737586 0.795243258163037 0.327102803738318 10.1 10 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.343956139127108 0.472898150703261 0.793852162084617 0.326530612244898 10.1 10 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.432683547316611 0.579217956567769 0.781448222052045 0.321428571428571 10.1 10 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.316910966261933 0.455980085936026 0.780376276617132 0.320987654320988 10.1 10 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.390458820156169 0.530174523933424 0.775906036080045 0.319148936170213 10.1 10 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.445528310755204 0.5947343210175 0.764082706006444 0.314285714285714 10.1 10 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.519910451162788 0.658800153165313 0.759741326995044 0.3125 10.1 10 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.519910451162788 0.658800153165313 0.759741326995044 0.3125 10.1 10 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.501116581453901 0.64011570503492 0.748052998887428 0.307692307692308 10.1 10 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.353251694752968 0.485209615476326 0.745927848322407 0.306818181818182 10.1 10 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.48853297462426 0.636650874271288 0.742858186395154 0.305555555555556 10.1 10 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.524119039876352 0.662363582365941 0.739921988029956 0.304347826086957 10.1 10 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.524119039876352 0.662363582365941 0.739921988029956 0.304347826086957 10.1 10 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.524119039876352 0.662363582365941 0.739921988029956 0.304347826086957 10.1 10 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.550435795406461 0.692546540109101 0.729351673915242 0.3 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.550435795406461 0.692546540109101 0.729351673915242 0.3 10.1 10 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.527634035221568 0.665623432730755 0.729351673915242 0.3 10.1 10 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.525047665865416 0.662948383785703 0.712161567122627 0.292929292929293 10.1 10 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.575700551952119 0.717985876799181 0.709091905195374 0.291666666666667 10.1 10 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.544896429638992 0.686791514062255 0.707809641352345 0.291139240506329 10.1 10 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.624431640253394 0.771994981825004 0.68072822898756 0.28 10.1 10 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.624431640253394 0.771994981825004 0.68072822898756 0.28 10.1 10 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.654924768459403 0.784476385115934 0.663046976286584 0.272727272727273 10.1 10 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.654924768459403 0.784476385115934 0.663046976286584 0.272727272727273 10.1 10 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.654924768459403 0.784476385115934 0.663046976286584 0.272727272727273 10.1 10 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.657275407042687 0.786629860573375 0.663046976286584 0.272727272727273 10.1 10 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.969130178621156 1 0.651170400165022 0.26784214945424 10.1 10 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.695562055671306 0.826197667128772 0.643545594631096 0.264705882352941 10.1 10 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.689747170227503 0.819975123837708 0.63978217010109 0.263157894736842 10.1 10 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.706848294700928 0.838204269466183 0.63978217010109 0.263157894736842 10.1 10 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.717319818900171 0.849913490670228 0.636735588338704 0.261904761904762 10.1 10 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.701091496194597 0.832071058452803 0.634218846882819 0.260869565217391 10.1 10 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.731036016941471 0.857596250707101 0.625158577641636 0.257142857142857 10.1 10 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.739869325808957 0.865328356523313 0.623377499072857 0.256410256410256 10.1 10 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.749832111535288 0.86678399245712 0.607793061596035 0.25 10.1 10 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.846679674302212 0.947189604191861 0.600642554989023 0.247058823529412 10.1 10 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.846679674302212 0.947189604191861 0.600642554989023 0.247058823529412 10.1 10 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.99966587768238 1 0.600099478537858 0.246835443037975 10.1 10 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.813425618704464 0.929751741756117 0.561039749165571 0.230769230769231 10.1 10 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.842802408584156 0.944336871980515 0.555696513459232 0.228571428571429 10.1 10 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.842114972762245 0.944336871980515 0.548974378215774 0.225806451612903 10.1 10 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.842114972762245 0.944336871980515 0.548974378215774 0.225806451612903 10.1 10 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.842114972762245 0.944336871980515 0.548974378215774 0.225806451612903 10.1 10 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.982061515750092 1 0.548974378215774 0.225806451612903 10.1 10 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.842487015570167 0.944336871980515 0.540260499196476 0.222222222222222 10.1 10 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.866008656590267 0.967669222103015 0.531818928896531 0.21875 10.1 10 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.927310566530002 1 0.506494217996696 0.208333333333333 10.1 10 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.893943373791513 0.983821671233816 0.486234449276828 0.2 10.1 10 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.998011187309626 1 0.427706228530543 0.175925925925926 10.1 10 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.970030342980816 1 0.39212455586841 0.161290322580645 10.1 10 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999666382737681 1 0.351169324477709 0.144444444444444 10.1 10 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.309778399136044 0.12741935483871 10.1 10 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 8.9438528142081e-06 4.8208721797796e-05 1.63385093167702 1 11.2 11 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 8.9438528142081e-06 4.8208721797796e-05 1.63385093167702 1 11.2 11 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 8.9438528142081e-06 4.8208721797796e-05 1.63385093167702 1 11.2 11 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 2.35692657151479e-05 0.000119356103603756 1.63385093167702 1 11.2 11 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 6.21078537267698e-05 0.000288821816513704 1.63385093167702 1 11.2 11 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 6.21078537267698e-05 0.000288821816513704 1.63385093167702 1 11.2 11 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000163653784410178 0.000684939221222598 1.63385093167702 1 11.2 11 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000163653784410178 0.000684939221222598 1.63385093167702 1 11.2 11 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.000163653784410178 0.000684939221222598 1.63385093167702 1 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0029932227767783 0.0083845590774715 1.63385093167702 1 11.2 11 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0029932227767783 0.0083845590774715 1.63385093167702 1 11.2 11 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0029932227767783 0.0083845590774715 1.63385093167702 1 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0029932227767783 0.0083845590774715 1.63385093167702 1 11.2 11 2 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605631 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 3.39376910867037e-06 2.0291316981672e-05 1.63385093167702 1 11.2 11 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 2.04362045282365e-08 1.67130569216555e-07 1.55958498023715 0.954545454545455 11.2 11 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 2.02603463130742e-06 1.27568463732321e-05 1.53774205334308 0.941176470588235 11.2 11 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.0367765394477e-06 2.82178465182444e-05 1.5317352484472 0.9375 11.2 11 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.0367765394477e-06 2.82178465182444e-05 1.5317352484472 0.9375 11.2 11 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 5.0367765394477e-06 2.82178465182444e-05 1.5317352484472 0.9375 11.2 11 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 3.07725017499129e-05 0.000152575853624133 1.51714729370009 0.928571428571429 11.2 11 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 3.07725017499129e-05 0.000152575853624133 1.51714729370009 0.928571428571429 11.2 11 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000184448807625487 0.000752064909028846 1.4976966873706 0.916666666666667 11.2 11 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.000184448807625487 0.000752064909028846 1.4976966873706 0.916666666666667 11.2 11 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000184448807625487 0.000752064909028846 1.4976966873706 0.916666666666667 11.2 11 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.50026884147028e-07 1.07822351586475e-06 1.49177693761815 0.91304347826087 11.2 11 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000447493733842988 0.00162444791647595 1.48531902879729 0.909090909090909 11.2 11 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.08203107267691e-06 1.30516749621993e-05 1.47046583850932 0.9 11.2 11 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00107756716056085 0.00354948627194002 1.47046583850932 0.9 11.2 11 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00107756716056085 0.00354948627194002 1.47046583850932 0.9 11.2 11 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00107756716056085 0.00354948627194002 1.47046583850932 0.9 11.2 11 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00107756716056085 0.00354948627194002 1.47046583850932 0.9 11.2 11 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 5.98511792148866e-08 4.65400153129966e-07 1.45231193926846 0.888888888888889 11.2 11 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.76173408504998e-05 0.000139359844078941 1.44163317500913 0.882352941176471 11.2 11 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.29264821421841e-07 2.24183655925014e-06 1.43778881987578 0.88 11.2 11 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.66699773367486e-07 4.98179807078508e-06 1.42961956521739 0.875 11.2 11 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 7.66699773367486e-07 4.98179807078508e-06 1.42961956521739 0.875 11.2 11 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 6.45472517966495e-05 0.000297251583516609 1.42961956521739 0.875 11.2 11 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 6.45472517966495e-05 0.000297251583516609 1.42961956521739 0.875 11.2 11 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.7756744438253e-06 1.12301543713929e-05 1.42073994058871 0.869565217391304 11.2 11 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000149702454471459 0.000642305133840642 1.41600414078675 0.866666666666667 11.2 11 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.43406727984611e-09 3.11253359186052e-08 1.40692719116632 0.861111111111111 11.2 11 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.66854889493427e-07 1.84337139684052e-06 1.40044365572316 0.857142857142857 11.2 11 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 9.35301010568427e-06 5.02238995486367e-05 1.40044365572316 0.857142857142857 11.2 11 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.12467106291632e-05 0.000109543729077171 1.38877329192547 0.85 11.2 11 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.36634851988437e-06 8.6799729633726e-06 1.38248924988055 0.846153846153846 11.2 11 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000783420534522029 0.00264799862381199 1.38248924988055 0.846153846153846 11.2 11 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000783420534522029 0.00264799862381199 1.38248924988055 0.846153846153846 11.2 11 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.24432807566407e-11 2.21334856458746e-10 1.37756058945317 0.843137254901961 11.2 11 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.24432807566407e-11 2.21334856458746e-10 1.37756058945317 0.843137254901961 11.2 11 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.17049212774402e-11 7.83983062301762e-10 1.36709975915832 0.836734693877551 11.2 11 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000107024582049109 0.000478918176905289 1.36154244306418 0.833333333333333 11.2 11 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000107024582049109 0.000478918176905289 1.36154244306418 0.833333333333333 11.2 11 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.46724834665944e-07 3.0127461598561e-06 1.36154244306418 0.833333333333333 11.2 11 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.50737268126888e-05 7.82843549432706e-05 1.34970294355928 0.826086956521739 11.2 11 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.46811868825003e-31 1.11159041333997e-28 1.34792701863354 0.825 11.2 11 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000236886836212014 0.000941592089189095 1.34552429667519 0.823529411764706 11.2 11 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000236886836212014 0.000941592089189095 1.34552429667519 0.823529411764706 11.2 11 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000236886836212014 0.000941592089189095 1.34552429667519 0.823529411764706 11.2 11 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 3.15199129402776e-09 2.93155791594869e-08 1.33678712591756 0.818181818181818 11.2 11 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 3.15199129402776e-09 2.93155791594869e-08 1.33678712591756 0.818181818181818 11.2 11 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 3.30438491649393e-05 0.000162142749523133 1.33678712591756 0.818181818181818 11.2 11 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 4.61971600509774e-08 3.61200872266708e-07 1.33287839163125 0.815789473684211 11.2 11 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.7136036169812e-06 2.69375821163223e-05 1.33128594432942 0.814814814814815 11.2 11 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000518708332728972 0.00181356746307943 1.32750388198758 0.8125 11.2 11 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000518708332728972 0.00181356746307943 1.32750388198758 0.8125 11.2 11 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000518708332728972 0.00181356746307943 1.32750388198758 0.8125 11.2 11 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000518708332728972 0.00181356746307943 1.32750388198758 0.8125 11.2 11 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 9.98542178253018e-08 7.59853219066334e-07 1.32474399865704 0.810810810810811 11.2 11 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.41134906894481e-12 6.55993206095739e-11 1.32264123040521 0.80952380952381 11.2 11 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.01901492261126e-05 5.43092971863604e-05 1.31964882943144 0.807692307692308 11.2 11 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.01901492261126e-05 5.43092971863604e-05 1.31964882943144 0.807692307692308 11.2 11 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.14575128184484e-07 1.49676670297314e-06 1.31615769496204 0.805555555555556 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.15817559755042e-08 2.51066138285712e-07 1.31505074988638 0.804878048780488 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.15817559755042e-08 2.51066138285712e-07 1.31505074988638 0.804878048780488 11.2 11 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 4.67824062850837e-09 4.13486733811641e-08 1.31418444504456 0.804347826086957 11.2 11 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 9.96887949189439e-09 8.54561175720826e-08 1.30708074534161 0.8 11.2 11 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000154470209993989 0.000654199728635259 1.30708074534161 0.8 11.2 11 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000154470209993989 0.000654199728635259 1.30708074534161 0.8 11.2 11 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.14514551827035e-06 1.88841437658173e-05 1.30708074534161 0.8 11.2 11 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.18498058962436e-05 0.000111043834965552 1.30708074534161 0.8 11.2 11 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.18498058962436e-05 0.000111043834965552 1.30708074534161 0.8 11.2 11 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.18498058962436e-05 0.000111043834965552 1.30708074534161 0.8 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0011220851344399 0.0036167599690813 1.30708074534161 0.8 11.2 11 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0011220851344399 0.0036167599690813 1.30708074534161 0.8 11.2 11 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0011220851344399 0.0036167599690813 1.30708074534161 0.8 11.2 11 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 1.42847477701345e-07 1.03710184065823e-06 1.29870202261507 0.794871794871795 11.2 11 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 6.6775013923728e-06 3.66875848700637e-05 1.29581280788177 0.793103448275862 11.2 11 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 6.62783127034808e-09 5.82185425784279e-08 1.29346532091097 0.791666666666667 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 4.64358070756714e-05 0.000223237004961758 1.29346532091097 0.791666666666667 11.2 11 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000328773975350286 0.00122794059559962 1.28988231448186 0.789473684210526 11.2 11 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.07403707198308e-13 2.35131500527989e-12 1.28665760869565 0.7875 11.2 11 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.39049848749844e-08 1.17778532601802e-07 1.2862230738734 0.787234042553192 11.2 11 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 6.52135147229233e-10 7.19370786439689e-09 1.28374001774623 0.785714285714286 11.2 11 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.40626035268609e-05 7.33006769916596e-05 1.28374001774623 0.785714285714286 11.2 11 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00239397286273059 0.00692403126761306 1.28374001774623 0.785714285714286 11.2 11 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00239397286273059 0.00692403126761306 1.28374001774623 0.785714285714286 11.2 11 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 4.28376132787051e-06 2.45798079417731e-05 1.27644604037267 0.78125 11.2 11 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 2.93580588580725e-05 0.000146584272824692 1.2707729468599 0.777777777777778 11.2 11 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 2.93580588580725e-05 0.000146584272824692 1.2707729468599 0.777777777777778 11.2 11 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 6.02039588682703e-08 4.65599094943199e-07 1.2707729468599 0.777777777777778 11.2 11 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.3111185075934e-06 8.36646473679553e-06 1.2707729468599 0.777777777777778 11.2 11 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000691404725782181 0.00237076849346517 1.2707729468599 0.777777777777778 11.2 11 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000691404725782181 0.00237076849346517 1.2707729468599 0.777777777777778 11.2 11 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0183164787123359 0.0377197528330738 1.2707729468599 0.777777777777778 11.2 11 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0183164787123359 0.0377197528330738 1.2707729468599 0.777777777777778 11.2 11 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0183164787123359 0.0377197528330738 1.2707729468599 0.777777777777778 11.2 11 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.99046390273639e-12 3.98933821632942e-11 1.26838427590716 0.776315789473684 11.2 11 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 8.77370647713565e-10 9.11312723865987e-09 1.26764296423217 0.775862068965517 11.2 11 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 8.77370647713565e-10 9.11312723865987e-09 1.26764296423217 0.775862068965517 11.2 11 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.02852092006696e-07 2.72980250916919e-06 1.26623447204969 0.775 11.2 11 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.24179884078183e-07 9.10865850738426e-07 1.2625211744777 0.772727272727273 11.2 11 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00020354863939658 0.000820537433034937 1.2625211744777 0.772727272727273 11.2 11 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00020354863939658 0.000820537433034937 1.2625211744777 0.772727272727273 11.2 11 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00020354863939658 0.000820537433034937 1.2625211744777 0.772727272727273 11.2 11 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.7069725296092e-06 1.63221267357368e-05 1.26039929015084 0.771428571428571 11.2 11 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.7069725296092e-06 1.63221267357368e-05 1.26039929015084 0.771428571428571 11.2 11 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.7069725296092e-06 1.63221267357368e-05 1.26039929015084 0.771428571428571 11.2 11 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 6.07153281300142e-05 0.000284203657661218 1.25680840898232 0.769230769230769 11.2 11 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00502704446629208 0.0130538034225066 1.25680840898232 0.769230769230769 11.2 11 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00502704446629208 0.0130538034225066 1.25680840898232 0.769230769230769 11.2 11 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.42535355481275e-08 1.96095347073781e-07 1.24941541834125 0.764705882352941 11.2 11 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00143462819640908 0.00441877905517343 1.24941541834125 0.764705882352941 11.2 11 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00143462819640908 0.00441877905517343 1.24941541834125 0.764705882352941 11.2 11 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00143462819640908 0.00441877905517343 1.24941541834125 0.764705882352941 11.2 11 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.33241474266511e-09 2.24258525595436e-08 1.24615749026213 0.76271186440678 11.2 11 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.33241474266511e-09 2.24258525595436e-08 1.24615749026213 0.76271186440678 11.2 11 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000419031080842119 0.0015447700208247 1.24483880508725 0.761904761904762 11.2 11 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000419031080842119 0.0015447700208247 1.24483880508725 0.761904761904762 11.2 11 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.25836826355061e-10 2.57092643122601e-09 1.24367757485863 0.761194029850746 11.2 11 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.04143241717975e-11 8.86721976074937e-10 1.24264718747266 0.76056338028169 11.2 11 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.46472675754987e-09 1.44743484443991e-08 1.23856441594871 0.758064516129032 11.2 11 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 1.12692595949191e-05 5.93931718650738e-05 1.23776585733107 0.757575757575758 11.2 11 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.86666569140564e-25 3.39938773239185e-23 1.23426782338644 0.755434782608696 11.2 11 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 9.9173736888502e-08 7.58732406410421e-07 1.23372417289897 0.755102040816326 11.2 11 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.70563924964868e-12 5.27414335924667e-11 1.23019364267446 0.752941176470588 11.2 11 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 2.10532588559832e-06 1.31398190140632e-05 1.22538819875776 0.75 11.2 11 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000251637737305151 0.000994350265707038 1.22538819875776 0.75 11.2 11 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000251637737305151 0.000994350265707038 1.22538819875776 0.75 11.2 11 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000851685271419176 0.00284494868833213 1.22538819875776 0.75 11.2 11 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000851685271419176 0.00284494868833213 1.22538819875776 0.75 11.2 11 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0029322155395727 0.00827885458891262 1.22538819875776 0.75 11.2 11 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0029322155395727 0.00827885458891262 1.22538819875776 0.75 11.2 11 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 9.61923460005037e-19 7.60453935326204e-17 1.2224496179454 0.748201438848921 11.2 11 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.13149676750658e-09 1.14192900720699e-08 1.21929174005748 0.746268656716418 11.2 11 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.13149676750658e-09 1.14192900720699e-08 1.21929174005748 0.746268656716418 11.2 11 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.3110463025583e-11 2.24773360065116e-10 1.21097186700767 0.741176470588235 11.2 11 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.3110463025583e-11 2.24773360065116e-10 1.21097186700767 0.741176470588235 11.2 11 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.3110463025583e-11 2.24773360065116e-10 1.21097186700767 0.741176470588235 11.2 11 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000150307526049848 0.000642305133840642 1.21025994939038 0.740740740740741 11.2 11 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000150307526049848 0.000642305133840642 1.21025994939038 0.740740740740741 11.2 11 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000150307526049848 0.000642305133840642 1.21025994939038 0.740740740740741 11.2 11 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000150307526049848 0.000642305133840642 1.21025994939038 0.740740740740741 11.2 11 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00170677082699148 0.00521187743950404 1.20389016018307 0.736842105263158 11.2 11 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.69389413671901e-09 2.53868301758355e-08 1.20136097917428 0.735294117647059 11.2 11 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00589166411552997 0.0152433418843621 1.19815734989648 0.733333333333333 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.98760610697444e-06 2.82178465182444e-05 1.19550068171489 0.731707317073171 11.2 11 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.98760610697444e-06 2.82178465182444e-05 1.19550068171489 0.731707317073171 11.2 11 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 5.91195850729055e-12 1.10693644156243e-10 1.1946436919789 0.731182795698925 11.2 11 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.86936357791155e-07 1.96303094777314e-06 1.19396798853321 0.730769230769231 11.2 11 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.86936357791155e-07 1.96303094777314e-06 1.19396798853321 0.730769230769231 11.2 11 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000296855311419533 0.00111309839810527 1.19396798853321 0.730769230769231 11.2 11 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.98518082171779e-11 7.67289397234631e-10 1.19175009134088 0.729411764705882 11.2 11 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.18358478580544e-13 4.63767335850917e-12 1.19103152028792 0.728971962616822 11.2 11 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.90547265963739e-10 2.18668354408387e-09 1.19008895023388 0.728395061728395 11.2 11 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.90547265963739e-10 2.18668354408387e-09 1.19008895023388 0.728395061728395 11.2 11 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 8.09269082964231e-15 1.95184729670865e-13 1.18825522303783 0.727272727272727 11.2 11 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000993650924696891 0.00330365716318616 1.18825522303783 0.727272727272727 11.2 11 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.93285662929198e-15 1.2534741041933e-13 1.18585954718493 0.725806451612903 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000174919613219901 0.000719394825467975 1.18313343328336 0.724137931034483 11.2 11 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.54257699354804e-24 3.60077647272776e-22 1.18259686483289 0.723809523809524 11.2 11 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 7.07764859018452e-10 7.51604025659147e-09 1.17885446969101 0.721518987341772 11.2 11 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 7.07764859018452e-10 7.51604025659147e-09 1.17885446969101 0.721518987341772 11.2 11 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 7.07764859018452e-10 7.51604025659147e-09 1.17885446969101 0.721518987341772 11.2 11 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7.07764859018452e-10 7.51604025659147e-09 1.17885446969101 0.721518987341772 11.2 11 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.34861521702229e-10 1.57301594575632e-09 1.17789253213925 0.720930232558139 11.2 11 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 5.78817395547172e-06 3.21741075727979e-05 1.17789253213925 0.720930232558139 11.2 11 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 5.78817395547172e-06 3.21741075727979e-05 1.17789253213925 0.720930232558139 11.2 11 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00057909954829133 0.00201481334283267 1.17637267080745 0.72 11.2 11 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00057909954829133 0.00201481334283267 1.17637267080745 0.72 11.2 11 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.35461853454299e-09 1.34798753472355e-08 1.17302118171683 0.717948717948718 11.2 11 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 3.44913785612679e-06 2.03656563040183e-05 1.17211045098569 0.717391304347826 11.2 11 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 3.44913785612679e-06 2.03656563040183e-05 1.17211045098569 0.717391304347826 11.2 11 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 3.44913785612679e-06 2.03656563040183e-05 1.17211045098569 0.717391304347826 11.2 11 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 9.40927502332443e-12 1.71658953310137e-10 1.17175167827342 0.717171717171717 11.2 11 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 6.41766793666891e-07 4.20845229211053e-06 1.17144029063635 0.716981132075472 11.2 11 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 7.71336645473159e-15 1.89243456294535e-13 1.16883182035356 0.715384615384615 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0003379652790452 0.00125896490073644 1.1670363797693 0.714285714285714 11.2 11 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00193332074786182 0.00570770834897795 1.1670363797693 0.714285714285714 11.2 11 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00193332074786182 0.00570770834897795 1.1670363797693 0.714285714285714 11.2 11 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 8.15978931130456e-09 7.12354612882601e-08 1.16383901982473 0.712328767123288 11.2 11 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.29392534860636e-17 1.25548298887186e-15 1.16116449861323 0.710691823899371 11.2 11 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.66681143950304e-18 1.72494212655129e-16 1.1601308390606 0.710059171597633 11.2 11 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.001114652227893 0.0036167599690813 1.15731107660455 0.708333333333333 11.2 11 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.001114652227893 0.0036167599690813 1.15731107660455 0.708333333333333 11.2 11 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.001114652227893 0.0036167599690813 1.15731107660455 0.708333333333333 11.2 11 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.75420051216327e-09 1.72153608883333e-08 1.15565065899106 0.707317073170732 11.2 11 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 8.12819078974578e-17 3.85547183126942e-15 1.15514301538948 0.707006369426752 11.2 11 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 9.22192593369054e-09 7.95321248705554e-08 1.15458799171843 0.706666666666667 11.2 11 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 4.41610762706266e-12 8.37882820441355e-11 1.15418827283606 0.706422018348624 11.2 11 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 5.67685747225353e-18 3.51224703609425e-16 1.15330654000731 0.705882352941177 11.2 11 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000115610385913495 0.000515716549074934 1.15330654000731 0.705882352941177 11.2 11 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0065264251631654 0.0163505334633528 1.15330654000731 0.705882352941177 11.2 11 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0065264251631654 0.0163505334633528 1.15330654000731 0.705882352941177 11.2 11 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000644906301672542 0.0022274312312622 1.14974695192087 0.703703703703704 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000644906301672542 0.0022274312312622 1.14974695192087 0.703703703703704 11.2 11 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 3.29256323789606e-09 3.04241395293902e-08 1.14974695192086 0.703703703703704 11.2 11 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 5.71828003351244e-13 1.17929166488235e-11 1.14774652225245 0.702479338842975 11.2 11 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 5.71828003351244e-13 1.17929166488235e-11 1.14774652225245 0.702479338842975 11.2 11 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.8110377807425e-27 4.44456306888509e-25 1.14729973511144 0.702205882352941 11.2 11 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 9.24075089451543e-12 1.7077387692072e-10 1.14369565217391 0.7 11.2 11 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00370197045666021 0.0101501039688391 1.14369565217391 0.7 11.2 11 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00370197045666021 0.0101501039688391 1.14369565217391 0.7 11.2 11 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00370197045666021 0.0101501039688391 1.14369565217391 0.7 11.2 11 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.14657570185843e-16 5.09867882420172e-15 1.14269328963914 0.699386503067485 11.2 11 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.22741030388806e-08 2.55144714579595e-07 1.14145750021271 0.698630136986301 11.2 11 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.18552528435117e-09 2.13013868467926e-08 1.13989599884443 0.697674418604651 11.2 11 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.83401098746479e-15 7.90847768231031e-14 1.13939604445897 0.697368421052632 11.2 11 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000217746120862067 0.00087282459151189 1.13874458874459 0.696969696969697 11.2 11 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000217746120862067 0.00087282459151189 1.13874458874459 0.696969696969697 11.2 11 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.3028539661674e-09 1.30560647454662e-08 1.13818828948287 0.696629213483146 11.2 11 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00211433807358136 0.00620351150248717 1.13659195247097 0.695652173913043 11.2 11 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00211433807358136 0.00620351150248717 1.13659195247097 0.695652173913043 11.2 11 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00211433807358136 0.00620351150248717 1.13659195247097 0.695652173913043 11.2 11 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 4.62978715025386e-10 5.14702118344629e-09 1.13509643674403 0.694736842105263 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000126975464183106 0.000559399645611639 1.13461870255349 0.694444444444444 11.2 11 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000126975464183106 0.000559399645611639 1.13461870255349 0.694444444444444 11.2 11 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000126975464183106 0.000559399645611639 1.13461870255349 0.694444444444444 11.2 11 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000126975464183106 0.000559399645611639 1.13461870255349 0.694444444444444 11.2 11 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 4.04700073049816e-09 3.5993012746868e-08 1.13408476434052 0.694117647058824 11.2 11 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 4.04700073049816e-09 3.5993012746868e-08 1.13408476434052 0.694117647058824 11.2 11 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 7.41899550099447e-05 0.000340555825739198 1.13112756808409 0.692307692307692 11.2 11 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 9.80770770037028e-11 1.21359722240234e-09 1.13112756808409 0.692307692307692 11.2 11 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00121414908125287 0.00383940920582851 1.13112756808409 0.692307692307692 11.2 11 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00121414908125287 0.00383940920582851 1.13112756808409 0.692307692307692 11.2 11 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00121414908125287 0.00383940920582851 1.13112756808409 0.692307692307692 11.2 11 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.40177752711558e-12 4.74684641817427e-11 1.12908397717518 0.691056910569106 11.2 11 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 9.91451143217208e-14 2.20442965124701e-12 1.1284150319496 0.690647482014389 11.2 11 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.16881033630352e-17 1.23448684342396e-15 1.12494654312188 0.688524590163934 11.2 11 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.16881033630352e-17 1.23448684342396e-15 1.12494654312188 0.688524590163934 11.2 11 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.78930091671801e-07 3.81397000207858e-06 1.12327251552795 0.6875 11.2 11 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.97755654438528e-13 4.26373176160645e-12 1.12035492457853 0.685714285714286 11.2 11 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000137022357358371 0.00059994712160296 1.11789800588428 0.684210526315789 11.2 11 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000137022357358371 0.00059994712160296 1.11789800588428 0.684210526315789 11.2 11 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00696419240497533 0.0173252548816082 1.11789800588428 0.684210526315789 11.2 11 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.49486020380611e-26 7.81918607001609e-24 1.11525660865326 0.68259385665529 11.2 11 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.19811825317204e-23 2.84432642141488e-21 1.11427381547322 0.681992337164751 11.2 11 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 2.18197880829612e-07 1.51461260692945e-06 1.11192632850242 0.680555555555556 11.2 11 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.08833345042324e-09 1.11417158269948e-08 1.11101863354037 0.68 11.2 11 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00225270167204653 0.00656884114615208 1.11101863354037 0.68 11.2 11 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 4.5223346316597e-08 3.5554045198076e-07 1.10940495360785 0.679012345679012 11.2 11 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 7.01670811859822e-13 1.42639652182361e-11 1.10868456078083 0.678571428571429 11.2 11 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00129289290499693 0.00406133908125966 1.10868456078083 0.678571428571429 11.2 11 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000745365573958903 0.00254965195130654 1.10680224403927 0.67741935483871 11.2 11 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.25332422327995e-35 3.56696073945475e-33 1.10457527775348 0.676056338028169 11.2 11 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.34520209049867e-14 7.67777834641872e-13 1.10284937888199 0.675 11.2 11 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 8.49827066232294e-05 0.000388843702652268 1.10189946554962 0.674418604651163 11.2 11 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.00390992414716e-08 8.55427438360127e-08 1.10107345395625 0.673913043478261 11.2 11 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 4.9667299045401e-05 0.000237169686381227 1.10107345395625 0.673913043478261 11.2 11 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.52994058717251e-09 3.1791806680674e-08 1.10034858663962 0.673469387755102 11.2 11 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.97677751131001e-22 5.83997317564362e-20 1.09970735785953 0.673076923076923 11.2 11 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.05353636250067e-18 7.89043286230763e-17 1.09913608130999 0.672727272727273 11.2 11 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 1.46331185834234e-07 1.05700140833561e-06 1.09612784023901 0.670886075949367 11.2 11 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 3.03332702861528e-08 2.43865783147996e-07 1.095422783738 0.670454545454545 11.2 11 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.43723003790903e-11 5.25933155262854e-10 1.09352227710667 0.669291338582677 11.2 11 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.11272626159046e-18 1.50320473512161e-16 1.09167618304877 0.668161434977579 11.2 11 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.94202457735453e-15 2.12075016226258e-13 1.08923395445135 0.666666666666667 11.2 11 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.64673290952627e-06 2.14433922737846e-05 1.08923395445135 0.666666666666667 11.2 11 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0128452570494182 0.0277371787273476 1.08923395445135 0.666666666666667 11.2 11 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0128452570494182 0.0277371787273476 1.08923395445135 0.666666666666667 11.2 11 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0128452570494182 0.0277371787273476 1.08923395445135 0.666666666666667 11.2 11 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0128452570494182 0.0277371787273476 1.08923395445135 0.666666666666667 11.2 11 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0419962263974481 0.0745145014508337 1.08923395445135 0.666666666666667 11.2 11 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0419962263974481 0.0745145014508337 1.08923395445135 0.666666666666667 11.2 11 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.62890556371977e-11 5.49354533741833e-10 1.08923395445135 0.666666666666667 11.2 11 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.02744556095549e-10 1.2603922700342e-09 1.08923395445135 0.666666666666667 11.2 11 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00723926987425702 0.0178753726889109 1.08923395445135 0.666666666666667 11.2 11 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00723926987425702 0.0178753726889109 1.08923395445135 0.666666666666667 11.2 11 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00723926987425702 0.0178753726889109 1.08923395445135 0.666666666666667 11.2 11 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.18864463953412e-15 7.97303009329616e-14 1.08072431418219 0.661458333333333 11.2 11 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.57507669920926e-09 2.44288942864986e-08 1.07924098239216 0.660550458715596 11.2 11 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.51916528278493e-39 1.25194304935074e-36 1.07784462603028 0.659695817490494 11.2 11 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 9.28768321105264e-05 0.00042224834534594 1.07764635919123 0.659574468085106 11.2 11 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000272498835615291 0.00106822546303184 1.0759506135434 0.658536585365854 11.2 11 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000272498835615291 0.00106822546303184 1.0759506135434 0.658536585365854 11.2 11 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.95858899767941e-06 2.30863612446631e-05 1.07297673125058 0.656716417910448 11.2 11 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.95858899767941e-06 2.30863612446631e-05 1.07297673125058 0.656716417910448 11.2 11 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.16068616288402e-08 1.75694651987655e-07 1.07273040968693 0.656565656565657 11.2 11 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 4.31409597206308e-56 3.06947928412288e-53 1.07110329963974 0.655569782330346 11.2 11 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 9.83241733977739e-10 1.01387897641328e-08 1.07092750143536 0.65546218487395 11.2 11 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.74927500285946e-07 1.2446091645345e-06 1.07045405868494 0.655172413793103 11.2 11 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.74927500285946e-07 1.2446091645345e-06 1.07045405868494 0.655172413793103 11.2 11 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 5.61438736758321e-05 0.000265424359603685 1.06828714763497 0.653846153846154 11.2 11 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00421441212132347 0.0111057563863765 1.06828714763497 0.653846153846154 11.2 11 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00421441212132347 0.0111057563863765 1.06828714763497 0.653846153846154 11.2 11 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00421441212132347 0.0111057563863765 1.06828714763497 0.653846153846154 11.2 11 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.60094250378361e-10 4.06677871657466e-09 1.06779234117474 0.653543307086614 11.2 11 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.41298640190348e-06 1.48644140688686e-05 1.06654158040028 0.652777777777778 11.2 11 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.41298640190348e-06 1.48644140688686e-05 1.06654158040028 0.652777777777778 11.2 11 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.08558857750865e-06 2.36333030316862e-05 1.06555495544153 0.652173913043478 11.2 11 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.08558857750865e-06 2.36333030316862e-05 1.06555495544153 0.652173913043478 11.2 11 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 5.14304117688408e-07 3.43593783789016e-06 1.06298735313927 0.650602409638554 11.2 11 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 5.14304117688408e-07 3.43593783789016e-06 1.06298735313927 0.650602409638554 11.2 11 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000479958613383457 0.00172035543285809 1.06200310559006 0.65 11.2 11 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000479958613383457 0.00172035543285809 1.06200310559006 0.65 11.2 11 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000824787459873478 0.00278121458625583 1.05979519892563 0.648648648648649 11.2 11 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00142108189777071 0.00441877905517343 1.05719766167337 0.647058823529412 11.2 11 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00142108189777071 0.00441877905517343 1.05719766167337 0.647058823529412 11.2 11 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 9.79796828269341e-05 0.00044121863500863 1.05719766167336 0.647058823529412 11.2 11 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 8.90106184670608e-07 5.75736863993762e-06 1.05602560218149 0.646341463414634 11.2 11 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.2015277633909e-05 6.30912917824816e-05 1.05571906354515 0.646153846153846 11.2 11 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00245601467324865 0.00707471433205025 1.0540973752755 0.645161290322581 11.2 11 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00245601467324865 0.00707471433205025 1.0540973752755 0.645161290322581 11.2 11 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.75198492596699e-10 7.39082657665463e-09 1.05210097873141 0.643939393939394 11.2 11 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.28210744686484e-06 2.45798079417731e-05 1.05193142176466 0.643835616438356 11.2 11 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 7.23561183826991e-06 3.96010601763773e-05 1.05033274179237 0.642857142857143 11.2 11 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000487619903841664 0.00173038185328351 1.05033274179237 0.642857142857143 11.2 11 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000487619903841664 0.00173038185328351 1.05033274179237 0.642857142857143 11.2 11 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00426016976416344 0.0111643122917211 1.05033274179237 0.642857142857143 11.2 11 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00426016976416344 0.0111643122917211 1.05033274179237 0.642857142857143 11.2 11 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.4463805543178e-101 4.90419952879423e-98 1.04844920986892 0.641704325371207 11.2 11 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.0304234631987e-15 7.97303009329616e-14 1.04771606829513 0.641255605381166 11.2 11 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.24317662608615e-11 5.19251561533444e-10 1.0473403408186 0.641025641025641 11.2 11 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.000835401524424513 0.00281034602661012 1.0473403408186 0.641025641025641 11.2 11 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00742216859680078 0.0180542665183718 1.04566459627329 0.64 11.2 11 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00742216859680078 0.0180542665183718 1.04566459627329 0.64 11.2 11 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00742216859680078 0.0180542665183718 1.04566459627329 0.64 11.2 11 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.50282688583058e-05 0.00017012022725382 1.04459321861318 0.639344262295082 11.2 11 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.50282688583058e-05 0.00017012022725382 1.04459321861318 0.639344262295082 11.2 11 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.50282688583058e-05 0.00017012022725382 1.04459321861318 0.639344262295082 11.2 11 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 5.98484538049171e-17 2.93670171601369e-15 1.04384920634921 0.638888888888889 11.2 11 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 5.98484538049171e-17 2.93670171601369e-15 1.04384920634921 0.638888888888889 11.2 11 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 5.98484538049171e-17 2.93670171601369e-15 1.04384920634921 0.638888888888889 11.2 11 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 7.34313176687397e-06 4.0035542161922e-05 1.04384920634921 0.638888888888889 11.2 11 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00143428976747749 0.00441877905517343 1.04384920634921 0.638888888888889 11.2 11 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 5.5199881414637e-11 7.20636983972738e-10 1.04355640152274 0.638709677419355 11.2 11 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.25713515234143e-10 4.77000261557626e-09 1.04288357341086 0.638297872340426 11.2 11 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.09276301454868e-05 0.000108290973443737 1.0397233201581 0.636363636363636 11.2 11 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00246858539396376 0.00709655962749581 1.0397233201581 0.636363636363636 11.2 11 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 5.32626021219632e-24 5.05284552130358e-22 1.0397233201581 0.636363636363636 11.2 11 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.5354392192189e-05 0.000171120068331581 1.03736567090604 0.634920634920635 11.2 11 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 3.43570272533718e-11 5.25933155262854e-10 1.03610059081957 0.634146341463415 11.2 11 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 7.79349141721222e-14 1.76033941058619e-12 1.03477225672878 0.633333333333333 11.2 11 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 9.43626617503495e-07 6.05550902621416e-06 1.03477225672878 0.633333333333333 11.2 11 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 5.97570251594731e-05 0.000280791867597129 1.03477225672878 0.633333333333333 11.2 11 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 9.56962598639571e-11 1.19452436654746e-09 1.03408286815001 0.632911392405063 11.2 11 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.39845876225837e-09 3.11253359186052e-08 1.03190585158549 0.631578947368421 11.2 11 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0229270821541773 0.0445050739185603 1.03190585158549 0.631578947368421 11.2 11 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0229270821541773 0.0445050739185603 1.03190585158549 0.631578947368421 11.2 11 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0229270821541773 0.0445050739185603 1.03190585158549 0.631578947368421 11.2 11 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0229270821541773 0.0445050739185603 1.03190585158549 0.631578947368421 11.2 11 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.65783671174446e-06 1.62321958833149e-05 1.03088213546288 0.630952380952381 11.2 11 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.65783671174446e-06 1.62321958833149e-05 1.03088213546288 0.630952380952381 11.2 11 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 3.55189261804869e-05 0.000171333667643501 1.0305828953655 0.630769230769231 11.2 11 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000492534041629009 0.00173914625617389 1.03003645692682 0.630434782608696 11.2 11 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000492534041629009 0.00173914625617389 1.03003645692682 0.630434782608696 11.2 11 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.22023474705928e-07 9.02344272027333e-07 1.02872095698183 0.62962962962963 11.2 11 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00737943383887038 0.0180428425304339 1.02872095698183 0.62962962962963 11.2 11 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00737943383887038 0.0180428425304339 1.02872095698183 0.62962962962963 11.2 11 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00737943383887038 0.0180428425304339 1.02872095698183 0.62962962962963 11.2 11 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 2.03979074910868e-07 1.42986317043431e-06 1.02699201419698 0.628571428571429 11.2 11 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000838098771007049 0.00281277016779017 1.02590639895999 0.627906976744186 11.2 11 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.22384008785155e-07 9.02344272027333e-07 1.02487012987013 0.627272727272727 11.2 11 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.87857669029931e-33 1.15703577171599e-30 1.0215145054443 0.625218914185639 11.2 11 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 5.97891327350177e-05 0.000280791867597129 1.02115683229814 0.625 11.2 11 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00142780637615961 0.00441877905517343 1.02115683229814 0.625 11.2 11 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00422531229150616 0.0111138990588045 1.02115683229814 0.625 11.2 11 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0128316852332417 0.0277371787273476 1.02115683229814 0.625 11.2 11 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0128316852332417 0.0277371787273476 1.02115683229814 0.625 11.2 11 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0407848275476798 0.0741210850579162 1.02115683229814 0.625 11.2 11 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0407848275476798 0.0741210850579162 1.02115683229814 0.625 11.2 11 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%REACT_212869.1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.57739566790537e-50 1.22254467847645e-47 1.020232708468 0.624434389140271 11.2 11 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000287909204103263 0.00111309839810527 1.01730341028946 0.622641509433962 11.2 11 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.43399857735367e-09 3.11253359186052e-08 1.01687225817661 0.622377622377622 11.2 11 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000169334976794537 0.000698445426025002 1.01411437138574 0.620689655172414 11.2 11 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000169334976794537 0.000698445426025002 1.01411437138574 0.620689655172414 11.2 11 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00727325424236079 0.0178753726889109 1.01411437138574 0.620689655172414 11.2 11 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00727325424236079 0.0178753726889109 1.01411437138574 0.620689655172414 11.2 11 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00727325424236079 0.0178753726889109 1.01411437138574 0.620689655172414 11.2 11 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.24639296162542e-05 6.52065141320946e-05 1.01340121078701 0.620253164556962 11.2 11 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 9.4471047352041e-07 6.05550902621416e-06 1.01298757763975 0.62 11.2 11 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000486235159677529 0.00173038185328351 1.01298757763975 0.62 11.2 11 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000486235159677529 0.00173038185328351 1.01298757763975 0.62 11.2 11 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 6.35326505876565e-15 1.58608704888132e-13 1.01234685178419 0.619607843137255 11.2 11 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0224205235154288 0.0440668576829492 1.01143152913339 0.619047619047619 11.2 11 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000285027673388353 0.00111121747734692 1.01001693958216 0.618181818181818 11.2 11 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000285027673388353 0.00111121747734692 1.01001693958216 0.618181818181818 11.2 11 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00416070642627558 0.0110460545608025 1.00914322250639 0.617647058823529 11.2 11 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00416070642627558 0.0110460545608025 1.00914322250639 0.617647058823529 11.2 11 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00416070642627558 0.0110460545608025 1.00914322250639 0.617647058823529 11.2 11 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00416070642627558 0.0110460545608025 1.00914322250639 0.617647058823529 11.2 11 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 5.59228058569334e-07 3.70130942950773e-06 1.00779590178209 0.616822429906542 11.2 11 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.000167485325565189 0.000694844368161121 1.00754140786749 0.616666666666667 11.2 11 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0125545789575645 0.0273586000866988 1.00544672718586 0.615384615384615 11.2 11 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0125545789575645 0.0273586000866988 1.00544672718586 0.615384615384615 11.2 11 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 5.69285407623225e-11 7.36448304588953e-10 1.00477463712758 0.614973262032086 11.2 11 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.18913379206143e-07 8.85935804242627e-07 1.00441655635882 0.614754098360656 11.2 11 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00138830197982686 0.00434187630174422 1.00259034443817 0.613636363636364 11.2 11 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.175526478652e-07 8.80407462695684e-07 1.00139250651172 0.612903225806452 11.2 11 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.175526478652e-07 8.80407462695684e-07 1.00139250651172 0.612903225806452 11.2 11 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.175526478652e-07 8.80407462695684e-07 1.00139250651172 0.612903225806452 11.2 11 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000165075349126784 0.000686848601776063 1.00139250651172 0.612903225806452 11.2 11 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000165075349126784 0.000686848601776063 1.00139250651172 0.612903225806452 11.2 11 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 5.46932245809988e-07 3.63684385882062e-06 1.00091768787421 0.612612612612613 11.2 11 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000471614183304904 0.00169900501985539 0.998464458247067 0.611111111111111 11.2 11 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000471614183304904 0.00169900501985539 0.998464458247067 0.611111111111111 11.2 11 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00234694827404188 0.00681572937543184 0.996250568095743 0.609756097560976 11.2 11 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000162184795868596 0.000684833722614277 0.995627911490683 0.609375 11.2 11 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0217399810310491 0.0432066941441101 0.994517958412098 0.608695652173913 11.2 11 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.00046196505660737 0.00167271316934424 0.991980922803904 0.607142857142857 11.2 11 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00692796905695604 0.0172653239370376 0.99021268586486 0.606060606060606 11.2 11 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 9.35043755218405e-05 0.000423747536202481 0.98951535298749 0.605633802816901 11.2 11 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 5.51308936337204e-05 0.00026150420546928 0.98890977443609 0.605263157894737 11.2 11 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0039684371443811 0.010634813665639 0.98890977443609 0.605263157894737 11.2 11 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 8.38181509318765e-09 7.2727578521988e-08 0.988635914072081 0.605095541401274 11.2 11 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000772208032756664 0.00262883260912137 0.986476034220087 0.60377358490566 11.2 11 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.78127603263623e-07 1.25482960120859e-06 0.985299416812858 0.603053435114504 11.2 11 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.78127603263623e-07 1.25482960120859e-06 0.985299416812858 0.603053435114504 11.2 11 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.50233543128423e-25 1.9434757442886e-23 0.982146346569893 0.601123595505618 11.2 11 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 3.10620451783901e-05 0.000152945641137886 0.980310559006211 0.6 11.2 11 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 3.10620451783901e-05 0.000152945641137886 0.980310559006211 0.6 11.2 11 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000751493948179736 0.00256445057136634 0.980310559006211 0.6 11.2 11 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.037783798493388 0.0697358563632829 0.980310559006211 0.6 11.2 11 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.037783798493388 0.0697358563632829 0.980310559006211 0.6 11.2 11 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 6.45669272831259e-06 3.56119137689489e-05 0.980310559006211 0.6 11.2 11 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.08873912594803e-05 5.75938950269163e-05 0.980310559006211 0.6 11.2 11 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.08873912594803e-05 5.75938950269163e-05 0.980310559006211 0.6 11.2 11 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.000151335468514072 0.000644761591902768 0.980310559006211 0.6 11.2 11 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00128988743295444 0.00406086242719948 0.980310559006211 0.6 11.2 11 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00222301502974418 0.00649558601093629 0.980310559006211 0.6 11.2 11 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00671088539318265 0.0167536665166647 0.980310559006211 0.6 11.2 11 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00671088539318265 0.0167536665166647 0.980310559006211 0.6 11.2 11 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0117917475527503 0.0260149717326568 0.980310559006211 0.6 11.2 11 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0117917475527503 0.0260149717326568 0.980310559006211 0.6 11.2 11 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.16343210937971e-06 1.34435104438748e-05 0.974577748719625 0.596491228070175 11.2 11 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 6.12759839671618e-06 3.39282977374597e-05 0.974026516961299 0.596153846153846 11.2 11 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00125063195649344 0.00394600725962341 0.974026516961299 0.596153846153846 11.2 11 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.00215266950489942 0.00630298087545654 0.973358001850139 0.595744680851064 11.2 11 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0037226795517005 0.0101677024991743 0.972530316474416 0.595238095238095 11.2 11 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0037226795517005 0.0101677024991743 0.972530316474416 0.595238095238095 11.2 11 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000142887531772118 0.000619905358877209 0.971478932348497 0.594594594594595 11.2 11 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000142887531772118 0.000619905358877209 0.971478932348497 0.594594594594595 11.2 11 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0113474989873017 0.0254291197778431 0.97009899068323 0.59375 11.2 11 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.82642916716626e-05 0.000231246084339313 0.968911599017767 0.593023255813954 11.2 11 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0200820627665742 0.041236328018521 0.968207959512307 0.592592592592593 11.2 11 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000138448794549062 0.000604333235102194 0.967411735861393 0.592105263157895 11.2 11 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0360266189142102 0.066665642022004 0.965457368718238 0.590909090909091 11.2 11 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0360266189142102 0.066665642022004 0.965457368718238 0.590909090909091 11.2 11 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0360266189142102 0.066665642022004 0.965457368718238 0.590909090909091 11.2 11 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.06594148835151 0.110915765867847 0.961088783339423 0.588235294117647 11.2 11 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.06594148835151 0.110915765867847 0.961088783339423 0.588235294117647 11.2 11 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.27846261876331e-07 9.32949900769327e-07 0.959228611500701 0.587096774193548 11.2 11 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00112355584943317 0.0036167599690813 0.957774684086528 0.586206896551724 11.2 11 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00112355584943317 0.0036167599690813 0.957774684086528 0.586206896551724 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00112355584943317 0.0036167599690813 0.957774684086528 0.586206896551724 11.2 11 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 2.99270511593753e-14 6.98134324586737e-13 0.957256220706474 0.585889570552147 11.2 11 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000372182458237402 0.00138280845449562 0.956969831410825 0.585714285714286 11.2 11 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00597279635127482 0.0152890126340356 0.956400545371913 0.585365853658537 11.2 11 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00330931941215007 0.00923365004605794 0.953079710144928 0.583333333333333 11.2 11 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0342115951479795 0.0635549606991839 0.953079710144928 0.583333333333333 11.2 11 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0342115951479795 0.0635549606991839 0.953079710144928 0.583333333333333 11.2 11 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00184657145286981 0.00547431495298694 0.950604178430265 0.581818181818182 11.2 11 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00184657145286981 0.00547431495298694 0.950604178430265 0.581818181818182 11.2 11 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00184657145286981 0.00547431495298694 0.950604178430265 0.581818181818182 11.2 11 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00184657145286981 0.00547431495298694 0.950604178430265 0.581818181818182 11.2 11 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.49279793146093e-09 2.38070567548249e-08 0.94918958887903 0.580952380952381 11.2 11 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0182621202057802 0.0377197528330738 0.948687637747946 0.580645161290323 11.2 11 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0182621202057802 0.0377197528330738 0.948687637747946 0.580645161290323 11.2 11 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000195220884755128 0.000793712340018707 0.948036960355801 0.580246913580247 11.2 11 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.000583892604043437 0.00202653457452149 0.947159960392475 0.579710144927536 11.2 11 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 2.15115827546679e-05 0.000110508961227049 0.946717362280142 0.579439252336449 11.2 11 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.32790948342379e-05 0.000293309941202347 0.945913697286695 0.578947368421053 11.2 11 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0620689709940981 0.10527311766937 0.945913697286695 0.578947368421053 11.2 11 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.57379180181628e-25 6.1011582569112e-23 0.94524501801532 0.578538102643857 11.2 11 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.032388752774728 0.0603261717257041 0.942606306736742 0.576923076923077 11.2 11 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.032388752774728 0.0603261717257041 0.942606306736742 0.576923076923077 11.2 11 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00169118059817276 0.00517537632516093 0.941541214864723 0.576271186440678 11.2 11 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00169118059817276 0.00517537632516093 0.941541214864723 0.576271186440678 11.2 11 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0173454324641994 0.0359803941640755 0.940702051571617 0.575757575757576 11.2 11 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0173454324641994 0.0359803941640755 0.940702051571617 0.575757575757576 11.2 11 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0173454324641994 0.0359803941640755 0.940702051571617 0.575757575757576 11.2 11 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0173454324641994 0.0359803941640755 0.940702051571617 0.575757575757576 11.2 11 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00944395656290754 0.0215364586362459 0.939464285714286 0.575 11.2 11 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 9.78667763275981e-05 0.00044121863500863 0.938595216069777 0.574468085106383 11.2 11 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.348699284066e-18 1.59152337201234e-16 0.934100633665851 0.571717171717172 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.91979740677672e-05 0.000146584272824692 0.933629103815439 0.571428571428571 11.2 11 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0049500870959743 0.0129010511677132 0.933629103815439 0.571428571428571 11.2 11 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00897295208404061 0.0205612090428177 0.933629103815439 0.571428571428571 11.2 11 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.016441622710922 0.034305614541997 0.933629103815439 0.571428571428571 11.2 11 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0305913268798741 0.0578875773272085 0.933629103815439 0.571428571428571 11.2 11 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0305913268798741 0.0578875773272085 0.933629103815439 0.571428571428571 11.2 11 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000252256110976979 0.000994350265707038 0.928324392998306 0.568181818181818 11.2 11 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 9.22154005453469e-08 7.09310891762317e-07 0.927550789337474 0.567708333333333 11.2 11 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0155590957016184 0.0325596958579456 0.927320799059929 0.567567567567568 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0155590957016184 0.0325596958579456 0.927320799059929 0.567567567567568 11.2 11 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0155590957016184 0.0325596958579456 0.927320799059929 0.567567567567568 11.2 11 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0288411769783738 0.0547213264536346 0.925848861283644 0.566666666666667 11.2 11 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00132811781872178 0.0041628010044958 0.923480961382663 0.565217391304348 11.2 11 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00806575986099952 0.0188465948804636 0.923480961382663 0.565217391304348 11.2 11 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0545992481623198 0.0931455889195265 0.923480961382663 0.565217391304348 11.2 11 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0545992481623198 0.0931455889195265 0.923480961382663 0.565217391304348 11.2 11 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000383626909814873 0.00142161742881918 0.920214892553723 0.563218390804598 11.2 11 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 8.41768877400342e-17 3.86399068561512e-15 0.919871357875069 0.563008130081301 11.2 11 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0271523474866811 0.0517239497637848 0.919041149068323 0.5625 11.2 11 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0271523474866811 0.0517239497637848 0.919041149068323 0.5625 11.2 11 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0138793279444382 0.0295662929115802 0.916550522648084 0.560975609756098 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0138793279444382 0.0295662929115802 0.916550522648084 0.560975609756098 11.2 11 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0138793279444382 0.0295662929115802 0.916550522648084 0.560975609756098 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0138793279444382 0.0295662929115802 0.916550522648084 0.560975609756098 11.2 11 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00721804964791628 0.0178753726889109 0.91495652173913 0.56 11.2 11 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0510951305517133 0.0900971137237771 0.91495652173913 0.56 11.2 11 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0510951305517133 0.0900971137237771 0.91495652173913 0.56 11.2 11 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 8.52372894824408e-10 8.98464169877876e-09 0.914248716281364 0.55956678700361 11.2 11 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0255334584959527 0.0487706193822022 0.913034344172452 0.558823529411765 11.2 11 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0255334584959527 0.0487706193822022 0.913034344172452 0.558823529411765 11.2 11 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0255334584959527 0.0487706193822022 0.913034344172452 0.558823529411765 11.2 11 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.00643770474611675 0.0161852541585232 0.907694962042788 0.555555555555556 11.2 11 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0477721152849204 0.0845518906100022 0.907694962042788 0.555555555555556 11.2 11 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000966867316359681 0.00322213627910966 0.907694962042788 0.555555555555556 11.2 11 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00180672416870723 0.00540119431107224 0.907694962042788 0.555555555555556 11.2 11 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0123326014691303 0.0271101194290184 0.907694962042788 0.555555555555556 11.2 11 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.099108501971902 0.153628974189561 0.907694962042788 0.555555555555556 11.2 11 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.099108501971902 0.153628974189561 0.907694962042788 0.555555555555556 11.2 11 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 4.36158040532016e-29 7.75816114596323e-27 0.901153016370408 0.551551551551552 11.2 11 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0109274644745658 0.0245264699484339 0.900285207250602 0.551020408163265 11.2 11 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0917508484949661 0.14269011738616 0.89861801242236 0.55 11.2 11 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0917508484949661 0.14269011738616 0.89861801242236 0.55 11.2 11 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0849580205904151 0.132763952281545 0.891191417278374 0.545454545454545 11.2 11 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00398943406767095 0.010670986237398 0.886947648624667 0.542857142857143 11.2 11 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.016314056650787 0.0340894311513507 0.885002587991718 0.541666666666667 11.2 11 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0786937471792671 0.123191641623869 0.885002587991718 0.541666666666667 11.2 11 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00752321620345597 0.0182688338865492 0.883886569595764 0.540983606557377 11.2 11 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00331674089958513 0.00923624716264118 0.881419581562602 0.539473684210526 11.2 11 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0729192379581963 0.119776268923541 0.879765886287625 0.538461538461538 11.2 11 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0626877441106527 0.105818101861754 0.871387163561076 0.533333333333333 11.2 11 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0626877441106527 0.105818101861754 0.871387163561076 0.533333333333333 11.2 11 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.167984853183247 0.233896718277652 0.871387163561076 0.533333333333333 11.2 11 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.167984853183247 0.233896718277652 0.871387163561076 0.533333333333333 11.2 11 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.32376104616673e-11 6.47653891441605e-10 0.868212266384425 0.531390134529148 11.2 11 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0224032478065153 0.0440668576829492 0.866941310685765 0.530612244897959 11.2 11 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.153315735172008 0.217515743918013 0.86497990500548 0.529411764705882 11.2 11 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.153315735172008 0.217515743918013 0.86497990500548 0.529411764705882 11.2 11 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.153315735172008 0.217515743918013 0.86497990500548 0.529411764705882 11.2 11 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.140263536391684 0.206979791401567 0.859921542987904 0.526315789473684 11.2 11 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000779215701996904 0.00264635786143579 0.857102128092862 0.524590163934426 11.2 11 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.128581800195695 0.194031709097003 0.855826678497486 0.523809523809524 11.2 11 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.128581800195695 0.194031709097003 0.855826678497486 0.523809523809524 11.2 11 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 8.71530669214757e-05 0.000397496199452756 0.854921999133324 0.523255813953488 11.2 11 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.118076681421065 0.180089086454636 0.852443964353227 0.521739130434783 11.2 11 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.108592248525784 0.16669554439287 0.84960248447205 0.52 11.2 11 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.100000754683263 0.154843388372451 0.847181964573269 0.518518518518518 11.2 11 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 5.36602287808332e-05 0.000255379617241223 0.845953274269319 0.517766497461929 11.2 11 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0850883517082005 0.132763952281545 0.843277900220397 0.516129032258065 11.2 11 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0850883517082005 0.132763952281545 0.843277900220397 0.516129032258065 11.2 11 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0183477729546578 0.0377295966972227 0.842454386645963 0.515625 11.2 11 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0726707552334162 0.119549693291504 0.840266193433895 0.514285714285714 11.2 11 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0622559974621349 0.105339220438309 0.837872272654882 0.512820512820513 11.2 11 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0622559974621349 0.105339220438309 0.837872272654882 0.512820512820513 11.2 11 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0275996888631138 0.0525058252034905 0.83031768658996 0.508196721311475 11.2 11 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00901073107272118 0.020614582502383 0.825709610632472 0.505376344086022 11.2 11 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0141285703800129 0.0297564228438056 0.816925465838509 0.5 11.2 11 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0644127795629483 0.108601167438478 0.816925465838509 0.5 11.2 11 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.132405407460397 0.199589930949307 0.816925465838509 0.5 11.2 11 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.172205579800975 0.239539139840457 0.816925465838509 0.5 11.2 11 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.188776224288401 0.261057888398829 0.816925465838509 0.5 11.2 11 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.207522968372114 0.28394729230146 0.816925465838509 0.5 11.2 11 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.228910925393573 0.307302119655712 0.816925465838509 0.5 11.2 11 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.228910925393573 0.307302119655712 0.816925465838509 0.5 11.2 11 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.228910925393573 0.307302119655712 0.816925465838509 0.5 11.2 11 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.228910925393573 0.307302119655712 0.816925465838509 0.5 11.2 11 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.282436901394669 0.368694128642978 0.816925465838509 0.5 11.2 11 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.282436901394669 0.368694128642978 0.816925465838509 0.5 11.2 11 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.316877658644968 0.410671136841339 0.816925465838509 0.5 11.2 11 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.316877658644968 0.410671136841339 0.816925465838509 0.5 11.2 11 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00934183560575601 0.0213377721781554 0.816925465838509 0.5 11.2 11 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.121704160271655 0.185224620392047 0.816925465838509 0.5 11.2 11 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.121704160271655 0.185224620392047 0.816925465838509 0.5 11.2 11 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0014737696094152 0.00452953381036249 0.811913653164653 0.496932515337423 11.2 11 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.0484689580878942 0.0856786675267993 0.803533245087058 0.491803278688525 11.2 11 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0561966828467859 0.0955410748996133 0.802593440122044 0.491228070175439 11.2 11 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0605507352219617 0.102820639881684 0.802072275550536 0.490909090909091 11.2 11 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00260279312030385 0.00737803707209638 0.801703252189345 0.490683229813665 11.2 11 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00321067898764537 0.00897602396742508 0.796754466682003 0.487654320987654 11.2 11 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000648209180804129 0.00223341807332755 0.792382640684563 0.484978540772532 11.2 11 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.143466094739622 0.206979791401567 0.792170148691888 0.484848484848485 11.2 11 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00449184475373538 0.011728247861588 0.791235985780694 0.484276729559748 11.2 11 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00449184475373538 0.011728247861588 0.791235985780694 0.484276729559748 11.2 11 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.00234520638703665 0.00681572937543184 0.790573031456622 0.483870967741935 11.2 11 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0051240321180502 0.0132814165828514 0.790573031456622 0.483870967741935 11.2 11 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.156031480799892 0.218428204617768 0.790573031456622 0.483870967741935 11.2 11 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0880431271914032 0.137223844461519 0.785505255613951 0.480769230769231 11.2 11 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.202567954558629 0.278817327928071 0.784248447204969 0.48 11.2 11 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.202567954558629 0.278817327928071 0.784248447204969 0.48 11.2 11 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.202567954558629 0.278817327928071 0.784248447204969 0.48 11.2 11 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0105787754835793 0.0237813546810954 0.78191437444543 0.478571428571429 11.2 11 2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.221823736649225 0.302932031911561 0.781406967323792 0.478260869565217 11.2 11 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0747634065013659 0.121865208993635 0.778024253179533 0.476190476190476 11.2 11 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.243498428009043 0.325962618115587 0.778024253179533 0.476190476190476 11.2 11 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0145855186497705 0.03065759680742 0.775184748605885 0.474452554744526 11.2 11 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.2680564571545 0.355824942659378 0.773929388689114 0.473684210526316 11.2 11 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.10053053286756 0.155494508989714 0.772365894974591 0.472727272727273 11.2 11 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.296106650034965 0.385155176416596 0.768871026671538 0.470588235294118 11.2 11 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0222928499098951 0.0440668576829492 0.763258829396563 0.467153284671533 11.2 11 2 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.32847131186265 0.41696224512092 0.762463768115942 0.466666666666667 11.2 11 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.32847131186265 0.41696224512092 0.762463768115942 0.466666666666667 11.2 11 2 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.32847131186265 0.41696224512092 0.762463768115942 0.466666666666667 11.2 11 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0232442635129605 0.0445776104837503 0.759395503455516 0.464788732394366 11.2 11 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0281839471050486 0.0535457366228092 0.756857416879795 0.463235294117647 11.2 11 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.252541693528849 0.335856850365937 0.754085045389393 0.461538461538462 11.2 11 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.237702976124879 0.318504081945106 0.742659514398645 0.454545454545455 11.2 11 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.237702976124879 0.318504081945106 0.742659514398645 0.454545454545455 11.2 11 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.302909134849101 0.393643560630384 0.742659514398645 0.454545454545455 11.2 11 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.411294210843682 0.501305866131068 0.742659514398645 0.454545454545455 11.2 11 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.332922102226763 0.421859440310493 0.735232919254658 0.45 11.2 11 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.332922102226763 0.421859440310493 0.735232919254658 0.45 11.2 11 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.142904418403219 0.206979791401567 0.734048969304168 0.449275362318841 11.2 11 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.281103386594541 0.368694128642978 0.732415934889698 0.448275862068966 11.2 11 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.281103386594541 0.368694128642978 0.732415934889698 0.448275862068966 11.2 11 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.123701729581775 0.188063633755199 0.72615596963423 0.444444444444444 11.2 11 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.227455205842116 0.306504505599745 0.72615596963423 0.444444444444444 11.2 11 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0919078952306117 0.142778313223974 0.720438206093803 0.440944881889764 11.2 11 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.334206759232768 0.422734416345093 0.718894409937888 0.44 11.2 11 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.334206759232768 0.422734416345093 0.718894409937888 0.44 11.2 11 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.264417854134004 0.351322695081875 0.717300409028935 0.439024390243902 11.2 11 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0454839265121894 0.0806022757494964 0.708658235426177 0.433734939759036 11.2 11 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.362539412537411 0.454531792106375 0.700221827861579 0.428571428571429 11.2 11 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.399989857890053 0.490254580342416 0.700221827861579 0.428571428571429 11.2 11 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.450846911331655 0.543690809173682 0.700221827861579 0.428571428571429 11.2 11 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.450846911331655 0.543690809173682 0.700221827861579 0.428571428571429 11.2 11 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.450846911331655 0.543690809173682 0.700221827861579 0.428571428571429 11.2 11 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.285092494010805 0.371167995404735 0.695899470899471 0.425925925925926 11.2 11 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.359285646157263 0.450849624763479 0.693148880105402 0.424242424242424 11.2 11 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.438913332245789 0.531100061042311 0.687937234390324 0.421052631578947 11.2 11 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.438913332245789 0.531100061042311 0.687937234390324 0.421052631578947 11.2 11 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.388374605844099 0.476428503548407 0.685163293929072 0.419354838709677 11.2 11 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.323366683599549 0.411583891558281 0.683246753246753 0.418181818181818 11.2 11 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.503335146164405 0.596374615313862 0.680771221532091 0.416666666666667 11.2 11 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.482767530584476 0.578751639445417 0.672762148337596 0.411764705882353 11.2 11 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.211501772404639 0.289113373805764 0.671203625986235 0.410810810810811 11.2 11 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.349810849649215 0.442078897913706 0.667347563642726 0.408450704225352 11.2 11 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.454466486525606 0.547591710690887 0.665642972164711 0.407407407407407 11.2 11 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.443569517569054 0.536278184792493 0.663751940993789 0.40625 11.2 11 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.509574152258473 0.603264574595514 0.653540372670807 0.4 11.2 11 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.477477109977343 0.572892013067251 0.653540372670807 0.4 11.2 11 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.315274781967271 0.409339429506776 0.647133114115211 0.396078431372549 11.2 11 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.513948710870909 0.607937668802413 0.641870008873114 0.392857142857143 11.2 11 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.55645458026944 0.653868594321564 0.635386473429952 0.388888888888889 11.2 11 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.22363380290771 0.304239162292258 0.633615361308893 0.38780487804878 11.2 11 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.533752375745708 0.629888501642676 0.632458425165297 0.387096774193548 11.2 11 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.533752375745708 0.629888501642676 0.632458425165297 0.387096774193548 11.2 11 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.588980278698998 0.68642009548622 0.628404204491161 0.384615384615385 11.2 11 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.551759221224859 0.64888708413469 0.624707709170625 0.382352941176471 11.2 11 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.565524404702716 0.659666301920414 0.616547521387554 0.377358490566038 11.2 11 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.608344730094426 0.70428811907903 0.612694099378882 0.375 11.2 11 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.608344730094426 0.70428811907903 0.612694099378882 0.375 11.2 11 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.609813601958832 0.70428811907903 0.607712846538403 0.371951219512195 11.2 11 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.602958376975352 0.702135655021216 0.606858917480036 0.371428571428571 11.2 11 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.625693277352659 0.713270218792226 0.59907867494824 0.366666666666667 11.2 11 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.653047627824867 0.740042632532073 0.590967358266156 0.361702127659574 11.2 11 2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.717231342437334 0.80809200339535 0.580924775707384 0.355555555555556 11.2 11 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.755405508792319 0.835910069784835 0.574873475960433 0.351851851851852 11.2 11 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.729633510115473 0.816407366805844 0.566846241602231 0.346938775510204 11.2 11 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.843562426630042 0.917027629891046 0.549853678929766 0.336538461538462 11.2 11 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.737034786424153 0.819375391469976 0.544616977225673 0.333333333333333 11.2 11 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.74775474638596 0.829996103047754 0.544616977225673 0.333333333333333 11.2 11 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.74775474638596 0.829996103047754 0.544616977225673 0.333333333333333 11.2 11 2 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.732366235365788 0.816407366805844 0.544616977225673 0.333333333333333 11.2 11 2 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_220332.1 ANDROGEN BIOSYNTHESIS 0.732366235365788 0.816407366805844 0.544616977225673 0.333333333333333 11.2 11 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.804975655505227 0.879785221032211 0.529897599462817 0.324324324324324 11.2 11 2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.792333501218327 0.86863680449436 0.522832298136646 0.32 11.2 11 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.900116736560956 0.96450761756494 0.517041434075006 0.316455696202532 11.2 11 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.836099065892744 0.912399517458109 0.515952925792743 0.315789473684211 11.2 11 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.96132193847187 1 0.488470897099315 0.298969072164948 11.2 11 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.972026240722951 1 0.478602798168016 0.292929292929293 11.2 11 2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.888735744983638 0.955189550688608 0.474343818873973 0.290322580645161 11.2 11 2 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.923840919721009 0.983265242156317 0.46681455190772 0.285714285714286 11.2 11 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.897552237819709 0.962484426840578 0.445595708639187 0.272727272727273 11.2 11 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.897552237819709 0.962484426840578 0.445595708639187 0.272727272727273 11.2 11 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.96952394670644 1 0.417961866242958 0.255813953488372 11.2 11 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999935059731 1 0.416884644938208 0.255154639175258 11.2 11 2 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.927039169545555 0.98593179242401 0.408462732919255 0.25 11.2 11 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.979942350775294 1 0.408462732919255 0.25 11.2 11 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999992358733548 1 0.399051149211438 0.244239631336406 11.2 11 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999979553651 1 0.373451641526176 0.228571428571429 11.2 11 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.981361209895267 1 0.373451641526176 0.228571428571429 11.2 11 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.994259971163883 1 0.369928512832533 0.226415094339623 11.2 11 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999998998949286 1 0.352763269339356 0.215909090909091 11.2 11 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.989695503741609 1 0.326770186335404 0.2 11.2 11 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.315521170684899 0.19311502938707 11.2 11 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.99964795958227 1 0.272308488612836 0.166666666666667 11.2 11 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.267384284478789 0.163652802893309 11.2 11 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.997906158740144 1 0.263524343818874 0.161290322580645 11.2 11 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0289876778200761 0.017741935483871 11.2 11 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00239472358480749 0.00664267380347184 1.73360193392425 1 11.3 11 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 1.56563629716227e-05 7.78986171630041e-05 1.73360193392425 1 11.3 11 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 4.28201527273883e-05 0.000182982214207428 1.73360193392425 1 11.3 11 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 4.28201527273883e-05 0.000182982214207428 1.73360193392425 1 11.3 11 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.000320255226042277 0.00110612423946155 1.73360193392425 1 11.3 11 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000320255226042277 0.00110612423946155 1.73360193392425 1 11.3 11 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000320255226042277 0.00110612423946155 1.73360193392425 1 11.3 11 3 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605631 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 2.84644373373329e-08 2.36870727082016e-07 1.58913510609723 0.916666666666667 11.3 11 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00012491065845378 0.000470232452327327 1.58913510609723 0.916666666666667 11.3 11 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00012491065845378 0.000470232452327327 1.58913510609723 0.916666666666667 11.3 11 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00012491065845378 0.000470232452327327 1.58913510609723 0.916666666666667 11.3 11 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000314458050285043 0.00109644642779317 1.57600175811296 0.909090909090909 11.3 11 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000314458050285043 0.00109644642779317 1.57600175811296 0.909090909090909 11.3 11 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.000785689893697496 0.00256430440076041 1.56024174053183 0.9 11.3 11 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 6.73682704203645e-06 3.9128591350277e-05 1.54097949682156 0.888888888888889 11.3 11 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0019454400197853 0.00560396993553539 1.54097949682156 0.888888888888889 11.3 11 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0019454400197853 0.00560396993553539 1.54097949682156 0.888888888888889 11.3 11 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0019454400197853 0.00560396993553539 1.54097949682156 0.888888888888889 11.3 11 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0019454400197853 0.00560396993553539 1.54097949682156 0.888888888888889 11.3 11 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.64503027414828e-05 8.12804888928127e-05 1.52964876522728 0.882352941176471 11.3 11 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 3.98939292819083e-05 0.00017307640661023 1.51690169218372 0.875 11.3 11 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 3.98939292819083e-05 0.00017307640661023 1.51690169218372 0.875 11.3 11 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 3.98939292819083e-05 0.00017307640661023 1.51690169218372 0.875 11.3 11 3 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 2.14305202734807e-06 1.40532858751903e-05 1.49720167020731 0.863636363636364 11.3 11 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000228995662740816 0.000819210396474225 1.48594451479222 0.857142857142857 11.3 11 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.000228995662740816 0.000819210396474225 1.48594451479222 0.857142857142857 11.3 11 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 1.19906341542216e-05 6.13765194297025e-05 1.47356164383562 0.85 11.3 11 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 1.19906341542216e-05 6.13765194297025e-05 1.47356164383562 0.85 11.3 11 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.000540761270397811 0.00181486624475492 1.46689394408975 0.846153846153846 11.3 11 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.97398831885479e-12 7.42453575040416e-11 1.46166437566163 0.843137254901961 11.3 11 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.97398831885479e-12 7.42453575040416e-11 1.46166437566163 0.843137254901961 11.3 11 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 1.52179457191707e-06 1.00255262770278e-05 1.45622562449637 0.84 11.3 11 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.52179457191707e-06 1.00255262770278e-05 1.45622562449637 0.84 11.3 11 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.52179457191707e-06 1.00255262770278e-05 1.45622562449637 0.84 11.3 11 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.65032587890895e-11 5.33608905821178e-10 1.44466827827021 0.833333333333333 11.3 11 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.10497286016104e-08 9.76631291931159e-08 1.44466827827021 0.833333333333333 11.3 11 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 6.50176812387148e-05 0.000269738076975776 1.44466827827021 0.833333333333333 11.3 11 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME DATABASE ID RELEASE 48%5605065 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 8.06182746428246e-06 4.29662190324867e-05 1.43210594541569 0.826086956521739 11.3 11 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 8.06182746428246e-06 4.29662190324867e-05 1.43210594541569 0.826086956521739 11.3 11 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000149297519803894 0.000548967366100622 1.4276721808788 0.823529411764706 11.3 11 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.000149297519803894 0.000548967366100622 1.4276721808788 0.823529411764706 11.3 11 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000149297519803894 0.000548967366100622 1.4276721808788 0.823529411764706 11.3 11 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 1.83356218193873e-05 8.96618207869008e-05 1.41840158230166 0.818181818181818 11.3 11 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 1.83356218193873e-05 8.96618207869008e-05 1.41840158230166 0.818181818181818 11.3 11 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.30307292079217e-06 1.49647158277957e-05 1.4125645387531 0.814814814814815 11.3 11 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000339132208496192 0.00116006041512039 1.40855157131346 0.8125 11.3 11 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000339132208496192 0.00116006041512039 1.40855157131346 0.8125 11.3 11 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000339132208496192 0.00116006041512039 1.40855157131346 0.8125 11.3 11 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000339132208496192 0.00116006041512039 1.40855157131346 0.8125 11.3 11 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 3.29968740996754e-30 5.86931898047976e-28 1.39771655922643 0.80625 11.3 11 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.42638382945347e-09 1.65019852789617e-08 1.39441894685212 0.804347826086957 11.3 11 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.45681968104209e-06 9.7326497940042e-06 1.3868815471394 0.8 11.3 11 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000760973887165737 0.00250938629483473 1.3868815471394 0.8 11.3 11 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 1.14917199636766e-05 5.96814507602619e-05 1.3868815471394 0.8 11.3 11 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 9.22501168154142e-05 0.000361630623218552 1.3868815471394 0.8 11.3 11 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 9.22501168154142e-05 0.000361630623218552 1.3868815471394 0.8 11.3 11 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 9.22501168154142e-05 0.000361630623218552 1.3868815471394 0.8 11.3 11 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 9.22501168154142e-05 0.000361630623218552 1.3868815471394 0.8 11.3 11 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 4.11519147020113e-07 2.95753407176576e-06 1.37668388870455 0.794117647058823 11.3 11 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 3.20903178576006e-06 2.04773642651864e-05 1.37492567173303 0.793103448275862 11.3 11 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 3.20903178576006e-06 2.04773642651864e-05 1.37492567173303 0.793103448275862 11.3 11 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.53368091575338e-05 0.000115558587920418 1.3724348643567 0.791666666666667 11.3 11 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 2.53368091575338e-05 0.000115558587920418 1.3724348643567 0.791666666666667 11.3 11 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 2.53368091575338e-05 0.000115558587920418 1.3724348643567 0.791666666666667 11.3 11 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 2.53368091575338e-05 0.000115558587920418 1.3724348643567 0.791666666666667 11.3 11 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.23577830485838e-09 1.46542710651123e-08 1.35968779131314 0.784313725490196 11.3 11 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 9.37372751014298e-09 8.33675890433341e-08 1.35673194828855 0.782608695652174 11.3 11 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.53212814977648e-05 0.000233596983891155 1.35673194828855 0.782608695652174 11.3 11 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.51852433048514e-05 7.58196534133458e-05 1.34835705971886 0.777777777777778 11.3 11 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 1.51852433048514e-05 7.58196534133458e-05 1.34835705971886 0.777777777777778 11.3 11 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.22914186966801e-14 5.46584025167994e-13 1.34609091340001 0.776470588235294 11.3 11 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.22914186966801e-14 5.46584025167994e-13 1.34609091340001 0.776470588235294 11.3 11 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.22914186966801e-14 5.46584025167994e-13 1.34609091340001 0.776470588235294 11.3 11 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 8.26613560108892e-12 1.33667170003972e-10 1.34548209797106 0.776119402985075 11.3 11 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.16375865637871e-10 2.79911688002446e-09 1.34503598321709 0.775862068965517 11.3 11 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.16375865637871e-10 2.79911688002446e-09 1.34503598321709 0.775862068965517 11.3 11 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 4.20125628690676e-06 2.53321512553742e-05 1.34214343271555 0.774193548387097 11.3 11 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00011951272457226 0.000458400558130259 1.33960149439601 0.772727272727273 11.3 11 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00011951272457226 0.000458400558130259 1.33960149439601 0.772727272727273 11.3 11 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 3.25781950073213e-05 0.000145782300300057 1.3335399491725 0.769230769230769 11.3 11 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 3.25781950073213e-05 0.000145782300300057 1.3335399491725 0.769230769230769 11.3 11 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 2.58832038298346e-08 2.16657641469733e-07 1.32786531109092 0.765957446808511 11.3 11 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 7.3123162523012e-09 6.62765988982459e-08 1.32569559653031 0.764705882352941 11.3 11 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.48575662040648e-06 1.60783257765383e-05 1.32569559653031 0.764705882352941 11.3 11 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000956094946746163 0.00303011828334029 1.32569559653031 0.764705882352941 11.3 11 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000956094946746163 0.00303011828334029 1.32569559653031 0.764705882352941 11.3 11 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.000956094946746163 0.00303011828334029 1.32569559653031 0.764705882352941 11.3 11 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.000956094946746163 0.00303011828334029 1.32569559653031 0.764705882352941 11.3 11 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 5.87489890123898e-15 2.98570754873681e-13 1.32350255170561 0.763440860215054 11.3 11 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 6.93061132745214e-07 4.88230689057643e-06 1.32301200220535 0.763157894736842 11.3 11 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000255193153346065 0.000896641622744322 1.32083956870419 0.761904761904762 11.3 11 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000255193153346065 0.000896641622744322 1.32083956870419 0.761904761904762 11.3 11 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000255193153346065 0.000896641622744322 1.32083956870419 0.761904761904762 11.3 11 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000255193153346065 0.000896641622744322 1.32083956870419 0.761904761904762 11.3 11 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.45703367027504e-08 4.43734795017222e-07 1.31904494972498 0.760869565217391 11.3 11 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 6.91795916047482e-05 0.000282247438061564 1.31753746978243 0.76 11.3 11 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 6.91795916047482e-05 0.000282247438061564 1.31753746978243 0.76 11.3 11 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 6.91795916047482e-05 0.000282247438061564 1.31753746978243 0.76 11.3 11 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 6.91795916047482e-05 0.000282247438061564 1.31753746978243 0.76 11.3 11 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.89615834908268e-05 9.15345648300542e-05 1.31514629470116 0.758620689655172 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 4.07338986418236e-07 2.94235217092969e-06 1.31077219394273 0.75609756097561 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 4.07338986418236e-07 2.94235217092969e-06 1.31077219394273 0.75609756097561 11.3 11 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 4.07338986418236e-07 2.94235217092969e-06 1.31077219394273 0.75609756097561 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 4.07338986418236e-07 2.94235217092969e-06 1.31077219394273 0.75609756097561 11.3 11 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.14319911724184e-07 9.13917047098391e-07 1.30983257229833 0.755555555555556 11.3 11 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.36821238845747e-12 3.74416582456727e-11 1.30555207369604 0.753086419753086 11.3 11 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.36821238845747e-12 3.74416582456727e-11 1.30555207369604 0.753086419753086 11.3 11 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000145274698518457 0.000538348687478553 1.30020145044319 0.75 11.3 11 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00783834772789007 0.0183453434486638 1.30020145044319 0.75 11.3 11 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00783834772789007 0.0183453434486638 1.30020145044319 0.75 11.3 11 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.00783834772789007 0.0183453434486638 1.30020145044319 0.75 11.3 11 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.00783834772789007 0.0183453434486638 1.30020145044319 0.75 11.3 11 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.34158846646482e-09 5.3908371544535e-08 1.30020145044319 0.75 11.3 11 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.37890870353791e-07 1.79110427784892e-06 1.30020145044319 0.75 11.3 11 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00202649892317437 0.00577897388312049 1.30020145044319 0.75 11.3 11 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00202649892317437 0.00577897388312049 1.30020145044319 0.75 11.3 11 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00202649892317437 0.00577897388312049 1.30020145044319 0.75 11.3 11 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00202649892317437 0.00577897388312049 1.30020145044319 0.75 11.3 11 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 5.84604988979245e-12 1.05426698411721e-10 1.29471536837381 0.746835443037975 11.3 11 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 5.84604988979245e-12 1.05426698411721e-10 1.29471536837381 0.746835443037975 11.3 11 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 5.84604988979245e-12 1.05426698411721e-10 1.29471536837381 0.746835443037975 11.3 11 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.18493568814013e-11 9.9960213326231e-10 1.29409721828149 0.746478873239437 11.3 11 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.87286741435476e-10 1.07000765513787e-08 1.29332207768952 0.746031746031746 11.3 11 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.38241140915419e-07 1.09897845543375e-06 1.29098016356062 0.74468085106383 11.3 11 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.00828679035166e-12 5.2922075975378e-11 1.28490496279092 0.741176470588235 11.3 11 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.26322147926979e-08 1.91700247916721e-07 1.28414958068463 0.740740740740741 11.3 11 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 8.2272342728664e-05 0.00032611014959022 1.28414958068463 0.740740740740741 11.3 11 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000301388479949996 0.00105634435214001 1.28135795116141 0.739130434782609 11.3 11 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.31346216851458e-18 3.78052833289813e-16 1.2801983512056 0.738461538461539 11.3 11 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.95844942124082e-28 6.25874836269521e-26 1.27956333218219 0.738095238095238 11.3 11 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0011179638399046 0.00351183784588133 1.27739089868103 0.736842105263158 11.3 11 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 5.478225622586e-15 2.8872278003481e-13 1.27236839187101 0.73394495412844 11.3 11 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00422195367956968 0.0110033701209298 1.27130808487779 0.733333333333333 11.3 11 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00422195367956968 0.0110033701209298 1.27130808487779 0.733333333333333 11.3 11 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00422195367956968 0.0110033701209298 1.27130808487779 0.733333333333333 11.3 11 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00422195367956968 0.0110033701209298 1.27130808487779 0.733333333333333 11.3 11 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.84311615985733e-14 1.49005969393593e-12 1.26686295171388 0.730769230769231 11.3 11 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000168526239512048 0.000613332068607788 1.26686295171388 0.730769230769231 11.3 11 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.000168526239512048 0.000613332068607788 1.26686295171388 0.730769230769231 11.3 11 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000168526239512048 0.000613332068607788 1.26686295171388 0.730769230769231 11.3 11 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000168526239512048 0.000613332068607788 1.26686295171388 0.730769230769231 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 7.31342109176627e-06 4.12976119586643e-05 1.26506087070148 0.72972972972973 11.3 11 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 7.31342109176627e-06 4.12976119586643e-05 1.26506087070148 0.72972972972973 11.3 11 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.5256872247542e-08 1.33193430725474e-07 1.2634725959109 0.728813559322034 11.3 11 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.5256872247542e-08 1.33193430725474e-07 1.2634725959109 0.728813559322034 11.3 11 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 2.61748192612972e-05 0.000118620279645943 1.26080140649037 0.727272727272727 11.3 11 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000617007630076213 0.00206588672376106 1.26080140649037 0.727272727272727 11.3 11 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 8.74570841755309e-09 7.82713401143273e-08 1.25825946817083 0.725806451612903 11.3 11 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.86164442883e-09 3.08493941077658e-08 1.24921315826895 0.720588235294118 11.3 11 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 5.26073019009892e-05 0.000223463255537635 1.24602639000806 0.71875 11.3 11 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 5.26073019009892e-05 0.000223463255537635 1.24602639000806 0.71875 11.3 11 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 8.2885359133738e-06 4.400965151019e-05 1.24463728589434 0.717948717948718 11.3 11 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 4.43847955785495e-11 6.25342218893822e-10 1.24411432905152 0.717647058823529 11.3 11 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.32427415011674e-06 8.88887790384961e-06 1.24367095259783 0.717391304347826 11.3 11 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.32427415011674e-06 8.88887790384961e-06 1.24367095259783 0.717391304347826 11.3 11 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 5.6784373715929e-09 5.65064082501867e-08 1.24198347505021 0.716417910447761 11.3 11 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 5.6784373715929e-09 5.65064082501867e-08 1.24198347505021 0.716417910447761 11.3 11 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.48054786705952e-07 5.19259493406132e-06 1.23828709566018 0.714285714285714 11.3 11 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.93977386226099e-05 0.000132382854620171 1.23828709566018 0.714285714285714 11.3 11 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000188686055395562 0.000681472733065698 1.23828709566018 0.714285714285714 11.3 11 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000188686055395562 0.000681472733065698 1.23828709566018 0.714285714285714 11.3 11 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000188686055395562 0.000681472733065698 1.23828709566018 0.714285714285714 11.3 11 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00124483383140837 0.00386258816867753 1.23828709566018 0.714285714285714 11.3 11 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00124483383140837 0.00386258816867753 1.23828709566018 0.714285714285714 11.3 11 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00862465490903582 0.0199235128823993 1.23828709566018 0.714285714285714 11.3 11 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00862465490903582 0.0199235128823993 1.23828709566018 0.714285714285714 11.3 11 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.02788487495592e-10 3.88169385320926e-09 1.23519137792103 0.7125 11.3 11 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.83862342253602e-09 2.09308890421501e-08 1.23489452827481 0.712328767123288 11.3 11 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 1.6434904025829e-05 8.12804888928127e-05 1.23176979515671 0.710526315789474 11.3 11 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 9.19280893553633e-06 4.84495078343267e-05 1.22620624594642 0.707317073170732 11.3 11 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 9.19280893553633e-06 4.84495078343267e-05 1.22620624594642 0.707317073170732 11.3 11 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.04526068039568e-09 2.29165822693154e-08 1.22507869997314 0.706666666666667 11.3 11 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 5.80559451091906e-05 0.000244022767409937 1.22371901218183 0.705882352941177 11.3 11 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00459546846660206 0.0117403081292185 1.22371901218183 0.705882352941177 11.3 11 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00459546846660206 0.0117403081292185 1.22371901218183 0.705882352941177 11.3 11 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00459546846660206 0.0117403081292185 1.22371901218183 0.705882352941177 11.3 11 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.15942231021754e-09 1.38643524994921e-08 1.22241162007479 0.705128205128205 11.3 11 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.14489252138508e-06 3.0632560911845e-05 1.22140136253754 0.704545454545455 11.3 11 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.14489252138508e-06 3.0632560911845e-05 1.22140136253754 0.704545454545455 11.3 11 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000373379244372586 0.00127414547899806 1.2199421016504 0.703703703703704 11.3 11 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 5.22194003497739e-14 1.90533863327508e-12 1.21781954036001 0.702479338842975 11.3 11 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 5.22194003497739e-14 1.90533863327508e-12 1.21781954036001 0.702479338842975 11.3 11 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 1.79638656490601e-05 8.8451836742604e-05 1.21352135374698 0.7 11.3 11 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.75796528749517e-15 1.00063384164225e-13 1.20977976683923 0.697841726618705 11.3 11 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.99690413817427e-20 8.00162161788874e-18 1.20598395403426 0.695652173913043 11.3 11 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00133842283036472 0.00406092897144775 1.20598395403426 0.695652173913043 11.3 11 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00133842283036472 0.00406092897144775 1.20598395403426 0.695652173913043 11.3 11 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00133842283036472 0.00406092897144775 1.20598395403426 0.695652173913043 11.3 11 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00133842283036472 0.00406092897144775 1.20598395403426 0.695652173913043 11.3 11 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.38604030380861e-09 1.61666832157348e-08 1.20506475894735 0.695121951219512 11.3 11 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 7.36458619681171e-11 9.9960213326231e-10 1.20439713304211 0.694736842105263 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 6.27247744642146e-05 0.000261751771444508 1.20389023189184 0.694444444444444 11.3 11 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 6.27247744642146e-05 0.000261751771444508 1.20389023189184 0.694444444444444 11.3 11 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.65399136939962e-09 2.90509978358127e-08 1.19853960863899 0.691358024691358 11.3 11 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.28934871791838e-13 7.40396187635877e-12 1.19801759661432 0.691056910569106 11.3 11 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.93016499774497e-05 9.24319716394344e-05 1.19701085913818 0.69047619047619 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000398736839916846 0.00135742230431022 1.19558754063742 0.689655172413793 11.3 11 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.75693473662407e-10 5.93782292124216e-09 1.19425911003671 0.688888888888889 11.3 11 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.07333360823406e-05 5.61527104601866e-05 1.19425911003671 0.688888888888889 11.3 11 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 5.9769217387285e-06 3.50006569309081e-05 1.19185132957293 0.6875 11.3 11 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.84584438439297e-09 3.08493941077658e-08 1.19054590642991 0.686746987951807 11.3 11 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.60253022289636e-09 1.83903266708187e-08 1.18933155932013 0.686046511627907 11.3 11 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 8.25631686135555e-13 2.38933175629112e-11 1.18916496293978 0.685950413223141 11.3 11 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.66557632061276e-13 1.41257768175148e-11 1.18835616438356 0.685483870967742 11.3 11 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.63659622207938e-13 8.33750316448658e-12 1.18758557678276 0.68503937007874 11.3 11 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.03285564139741e-08 2.50915905680727e-07 1.18739858487963 0.684931506849315 11.3 11 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.7039101877721e-08 1.47845377878031e-07 1.18614869163238 0.684210526315789 11.3 11 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00481934714540766 0.0120103870191158 1.18614869163238 0.684210526315789 11.3 11 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00481934714540766 0.0120103870191158 1.18614869163238 0.684210526315789 11.3 11 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.5899197225734e-18 1.93971356064313e-16 1.18415432645099 0.683060109289617 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 3.68553724166501e-05 0.000162369024609576 1.18392327194827 0.682926829268293 11.3 11 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 3.68553724166501e-05 0.000162369024609576 1.18392327194827 0.682926829268293 11.3 11 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.68553724166501e-05 0.000162369024609576 1.18392327194827 0.682926829268293 11.3 11 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.25275520132521e-07 2.43614244815041e-06 1.18325211363084 0.682539682539683 11.3 11 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.02898307570934e-09 3.21659919159283e-08 1.18292837844243 0.682352941176471 11.3 11 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.02898307570934e-09 3.21659919159283e-08 1.18292837844243 0.682352941176471 11.3 11 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.89593521371084e-11 4.33780611485318e-10 1.1827377680044 0.682242990654206 11.3 11 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00259017569140584 0.00706095787139944 1.18200131858472 0.681818181818182 11.3 11 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00259017569140584 0.00706095787139944 1.18200131858472 0.681818181818182 11.3 11 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00259017569140584 0.00706095787139944 1.18200131858472 0.681818181818182 11.3 11 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.13539848429971e-05 5.91821261230213e-05 1.18032472096971 0.680851063829787 11.3 11 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.71349808333098e-10 2.27879231082241e-09 1.17884931506849 0.68 11.3 11 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.00140211695107788 0.00423611979062384 1.17884931506849 0.68 11.3 11 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00140211695107788 0.00423611979062384 1.17884931506849 0.68 11.3 11 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.51914904451149e-06 2.17728221319124e-05 1.17754093625044 0.679245283018868 11.3 11 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.06709856594394e-11 4.54633464514399e-10 1.17694076248069 0.678899082568807 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.7292073160966e-11 2.67463262044072e-10 1.17637274087717 0.678571428571429 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000763287087768528 0.00250938629483473 1.17637274087717 0.678571428571429 11.3 11 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000763287087768528 0.00250938629483473 1.17637274087717 0.678571428571429 11.3 11 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 6.12565644037514e-07 4.35840455732691e-06 1.17437550362611 0.67741935483871 11.3 11 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000229125606322376 0.000819210396474225 1.17273072000758 0.676470588235294 11.3 11 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.000126165926350017 0.000473704784158507 1.17135265805693 0.675675675675676 11.3 11 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 6.96573014330394e-05 0.000282247438061564 1.17018130539887 0.675 11.3 11 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 6.96573014330394e-05 0.000282247438061564 1.17018130539887 0.675 11.3 11 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 3.85463986264828e-05 0.000168773923832262 1.16917339729775 0.674418604651163 11.3 11 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 2.13728062462074e-05 0.00010137834429451 1.16829695547069 0.673913043478261 11.3 11 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 5.98387397499527e-10 7.34056264346403e-09 1.16752783305103 0.673469387755102 11.3 11 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.18711200299644e-05 6.1205086241447e-05 1.16752783305103 0.673469387755102 11.3 11 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.06657097733174e-12 1.05426698411721e-10 1.16520785722778 0.672131147540984 11.3 11 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 7.14618227004676e-20 6.77934491351769e-18 1.15836129221302 0.668181818181818 11.3 11 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00078521603010058 0.00256430440076041 1.15573462261617 0.666666666666667 11.3 11 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00078521603010058 0.00256430440076041 1.15573462261617 0.666666666666667 11.3 11 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0174300573679681 0.0364213974076632 1.15573462261617 0.666666666666667 11.3 11 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0174300573679681 0.0364213974076632 1.15573462261617 0.666666666666667 11.3 11 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0174300573679681 0.0364213974076632 1.15573462261617 0.666666666666667 11.3 11 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0174300573679681 0.0364213974076632 1.15573462261617 0.666666666666667 11.3 11 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.25339226077176e-17 1.39416399438183e-15 1.15573462261617 0.666666666666667 11.3 11 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.05632507722123e-08 1.76274131619627e-07 1.15573462261617 0.666666666666667 11.3 11 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.05632507722123e-08 1.76274131619627e-07 1.15573462261617 0.666666666666667 11.3 11 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 2.21081110515345e-05 0.000104517747595792 1.15573462261617 0.666666666666667 11.3 11 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000236299274311306 0.000842741522167891 1.15573462261617 0.666666666666667 11.3 11 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000429997776915704 0.00145687342035963 1.15573462261617 0.666666666666667 11.3 11 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00143993074272573 0.00429564244632853 1.15573462261617 0.666666666666667 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00143993074272573 0.00429564244632853 1.15573462261617 0.666666666666667 11.3 11 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00143993074272573 0.00429564244632853 1.15573462261617 0.666666666666667 11.3 11 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00143993074272573 0.00429564244632853 1.15573462261617 0.666666666666667 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00265422459281239 0.00720414572324974 1.15573462261617 0.666666666666667 11.3 11 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00265422459281239 0.00720414572324974 1.15573462261617 0.666666666666667 11.3 11 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0049243373066822 0.0122078954484473 1.15573462261617 0.666666666666667 11.3 11 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0049243373066822 0.0122078954484473 1.15573462261617 0.666666666666667 11.3 11 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0049243373066822 0.0122078954484473 1.15573462261617 0.666666666666667 11.3 11 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00921276194810029 0.0209421090289884 1.15573462261617 0.666666666666667 11.3 11 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.00921276194810029 0.0209421090289884 1.15573462261617 0.666666666666667 11.3 11 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 3.80255818793179e-11 5.46569727416863e-10 1.15087859479005 0.663865546218487 11.3 11 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.12664584633495e-10 2.79911688002446e-09 1.15048128342246 0.663636363636364 11.3 11 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.12246906901104e-08 1.80854699712737e-07 1.14901523527538 0.662790697674419 11.3 11 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.07174025325864e-35 3.05017276077408e-33 1.14759564640056 0.661971830985915 11.3 11 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.96281965710621e-12 8.9509402731145e-11 1.14704488861154 0.661654135338346 11.3 11 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.17929639392856e-09 2.42276466293777e-08 1.14417727639001 0.66 11.3 11 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.84911975954444e-19 4.05899848107749e-17 1.14277795644334 0.659192825112108 11.3 11 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000132918164536076 0.000493844773198007 1.14164029795012 0.658536585365854 11.3 11 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000132918164536076 0.000493844773198007 1.14164029795012 0.658536585365854 11.3 11 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 9.71630791254655e-23 1.25693692359579e-20 1.14086303739868 0.658088235294118 11.3 11 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000240737048405889 0.000856422049703951 1.14052758810806 0.657894736842105 11.3 11 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.29940895444258e-42 6.1635298072393e-40 1.14035412383611 0.657794676806084 11.3 11 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000437165714703769 0.00147364980970131 1.13922412800737 0.657142857142857 11.3 11 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.000796331284251695 0.00258716761984055 1.13767626913779 0.65625 11.3 11 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.99294035727086e-06 2.44911815879157e-05 1.13678815339295 0.655737704918033 11.3 11 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00267375574996555 0.00723337344524901 1.13350895679663 0.653846153846154 11.3 11 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 7.44608757033063e-11 9.9960213326231e-10 1.13243352135375 0.653225806451613 11.3 11 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 7.44608757033063e-11 9.9960213326231e-10 1.13243352135375 0.653225806451613 11.3 11 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 7.44608757033063e-11 9.9960213326231e-10 1.13243352135375 0.653225806451613 11.3 11 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.10559132323091e-07 4.9809145088461e-06 1.13165681797833 0.652777777777778 11.3 11 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.26795467491784e-06 8.62718256457746e-06 1.13060995690712 0.652173913043478 11.3 11 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.26795467491784e-06 8.62718256457746e-06 1.13060995690712 0.652173913043478 11.3 11 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 7.23707592498921e-06 4.12976119586643e-05 1.12684125705077 0.65 11.3 11 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000242746051867736 0.0008614155406678 1.12684125705077 0.65 11.3 11 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0091799411486178 0.0209343850232101 1.12684125705077 0.65 11.3 11 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0091799411486178 0.0209343850232101 1.12684125705077 0.65 11.3 11 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.34093371561378e-09 2.58228579637086e-08 1.12363088309905 0.648148148148148 11.3 11 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.32190794736625e-05 0.000107976307486999 1.12363088309905 0.648148148148148 11.3 11 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.39934918954083e-11 2.18898816871731e-10 1.12247607232506 0.647482014388489 11.3 11 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00145394649773853 0.00432838047339315 1.11845286059629 0.645161290322581 11.3 11 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.18295065113268e-09 4.25167055468701e-08 1.11793021907265 0.644859813084112 11.3 11 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00265788932164871 0.00720414572324974 1.11445838609416 0.642857142857143 11.3 11 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 4.08440894594018e-06 2.47323997024378e-05 1.11261019639915 0.641791044776119 11.3 11 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.08440894594018e-06 2.47323997024378e-05 1.11261019639915 0.641791044776119 11.3 11 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.69902906220861e-13 8.3493877293975e-12 1.11154476939849 0.641176470588235 11.3 11 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.000438056127550004 0.00147364980970131 1.11128329097709 0.641025641025641 11.3 11 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 7.28118085719558e-06 4.12976119586643e-05 1.11058873892023 0.640625 11.3 11 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.39540321957525e-13 2.38933175629112e-11 1.1099280674515 0.640243902439024 11.3 11 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 7.46663393829403e-05 0.000296788270787497 1.10950523771152 0.64 11.3 11 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.29880435223081e-05 6.55389572065403e-05 1.10836844955813 0.639344262295082 11.3 11 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.29880435223081e-05 6.55389572065403e-05 1.10836844955813 0.639344262295082 11.3 11 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.76823136463407e-13 1.41358192330714e-11 1.10786395777408 0.63905325443787 11.3 11 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.28987275718559e-06 1.49471969425463e-05 1.1075790133405 0.638888888888889 11.3 11 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000792544801551969 0.00258075801512231 1.1075790133405 0.638888888888889 11.3 11 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.08108963556843e-21 2.11527896529563e-19 1.10642853803357 0.638225255972696 11.3 11 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.48105687719896e-12 3.97649799293231e-11 1.10610184741179 0.638036809815951 11.3 11 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.31834917255449e-05 0.000107976307486999 1.10591847508961 0.637931034482759 11.3 11 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.31834917255449e-05 0.000107976307486999 1.10591847508961 0.637931034482759 11.3 11 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 4.07283018680718e-06 2.47323997024378e-05 1.10548529119808 0.63768115942029 11.3 11 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.60980630527274e-12 6.75228067709655e-11 1.10517123287671 0.6375 11.3 11 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 7.42410690469586e-09 6.68639501606469e-08 1.10320123067907 0.636363636363636 11.3 11 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 4.14127070245156e-05 0.000178037106029866 1.10320123067907 0.636363636363636 11.3 11 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 4.14127070245156e-05 0.000178037106029866 1.10320123067907 0.636363636363636 11.3 11 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 4.11410455532694e-08 3.38402935389031e-07 1.10320123067907 0.636363636363636 11.3 11 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0090091201334158 0.0207088918752394 1.10320123067907 0.636363636363636 11.3 11 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.29013709812048e-05 6.55389572065403e-05 1.10069964058683 0.634920634920635 11.3 11 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.31588631573798e-08 1.95000368479003e-07 1.10017045806732 0.634615384615385 11.3 11 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 7.40350591193872e-05 0.000295103330887641 1.10017045806732 0.634615384615385 11.3 11 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 7.40350591193872e-05 0.000295103330887641 1.10017045806732 0.634615384615385 11.3 11 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.33821397925446e-09 1.5737838780819e-08 1.09935732395197 0.634146341463415 11.3 11 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 7.18629619567462e-07 5.01279386590441e-06 1.09935732395197 0.634146341463415 11.3 11 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.52366808930656e-13 5.28824314898349e-12 1.09889521494652 0.633879781420765 11.3 11 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.28299981708e-10 5.39354755726092e-09 1.09838901157033 0.633587786259542 11.3 11 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.28299981708e-10 5.39354755726092e-09 1.09838901157033 0.633587786259542 11.3 11 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.29783276802114e-05 0.000107914720425547 1.09794789148536 0.633333333333333 11.3 11 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.27316116553849e-06 8.62718256457746e-06 1.09721641387611 0.632911392405063 11.3 11 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.02400990876232e-07 2.94235217092969e-06 1.0959552455843 0.632183908045977 11.3 11 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.02400990876232e-07 2.94235217092969e-06 1.0959552455843 0.632183908045977 11.3 11 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.48218354995961e-11 3.7576033953112e-10 1.09490648458374 0.631578947368421 11.3 11 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0167443301812876 0.0358843100120065 1.09490648458374 0.631578947368421 11.3 11 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0167443301812876 0.0358843100120065 1.09490648458374 0.631578947368421 11.3 11 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.39984485842077e-11 2.18898816871731e-10 1.09316300292039 0.630573248407643 11.3 11 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 7.30104632121388e-05 0.000292658842678517 1.09152714358194 0.62962962962963 11.3 11 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00477125826227321 0.0119323383255093 1.09152714358194 0.62962962962963 11.3 11 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00477125826227321 0.0119323383255093 1.09152714358194 0.62962962962963 11.3 11 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00477125826227321 0.0119323383255093 1.09152714358194 0.62962962962963 11.3 11 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.38573654577763e-11 2.18898816871731e-10 1.09031568171337 0.628930817610063 11.3 11 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 8.67866477407992e-15 4.25853102535025e-13 1.08969264418096 0.628571428571429 11.3 11 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 7.08574121517432e-06 4.06572973757784e-05 1.08969264418096 0.628571428571429 11.3 11 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00140935185243373 0.00423997396620126 1.08969264418096 0.628571428571429 11.3 11 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00140935185243373 0.00423997396620126 1.08969264418096 0.628571428571429 11.3 11 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.43282294594441e-11 3.7224807011601e-10 1.08905762515754 0.628205128205128 11.3 11 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 4.02953585046986e-05 0.000174286611404821 1.08717409415589 0.627118644067797 11.3 11 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 4.21247068006279e-11 5.99434577772934e-10 1.0848992747784 0.625806451612903 11.3 11 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.96576317029336e-06 4.01306922725808e-05 1.08350120870266 0.625 11.3 11 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.96576317029336e-06 4.01306922725808e-05 1.08350120870266 0.625 11.3 11 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.22683545212203e-05 0.000104926716833432 1.08350120870266 0.625 11.3 11 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 7.16524130652853e-05 0.000288026507886726 1.08350120870266 0.625 11.3 11 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000763572920353786 0.00250938629483473 1.08350120870266 0.625 11.3 11 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0313935627418492 0.0617040892823033 1.08350120870266 0.625 11.3 11 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0313935627418492 0.0617040892823033 1.08350120870266 0.625 11.3 11 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0313935627418492 0.0617040892823033 1.08350120870266 0.625 11.3 11 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.61321443190953e-17 1.09314482695584e-15 1.08267093957722 0.624521072796935 11.3 11 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000127453357694653 0.000476026582675829 1.07941252489623 0.622641509433962 11.3 11 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000127453357694653 0.000476026582675829 1.07941252489623 0.622641509433962 11.3 11 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00041541563226193 0.00141082683701367 1.07868564777509 0.622222222222222 11.3 11 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.88257277208829e-09 4.0396643227512e-08 1.07838230535446 0.622047244094488 11.3 11 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.95472892420175e-10 8.45861475140094e-09 1.07730977322436 0.621428571428571 11.3 11 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 7.00164059281321e-05 0.000282247438061564 1.07602878657368 0.620689655172414 11.3 11 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 7.00164059281321e-05 0.000282247438061564 1.07602878657368 0.620689655172414 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 7.00164059281321e-05 0.000282247438061564 1.07602878657368 0.620689655172414 11.3 11 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.78358721099641e-06 2.33075523863545e-05 1.07527208559859 0.620253164556962 11.3 11 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.80615599391165e-09 4.0119703550639e-08 1.07510197452667 0.62015503875969 11.3 11 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000226785528147056 0.000817002041906989 1.07483319903304 0.62 11.3 11 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.20437419683307e-05 6.14274007918804e-05 1.0743448604601 0.619718309859155 11.3 11 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 6.63877315311043e-07 4.69998716262495e-06 1.07407945906177 0.619565217391304 11.3 11 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000742638865460742 0.00246334523438377 1.07318214957216 0.619047619047619 11.3 11 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 6.66456899458371e-06 3.88675478659534e-05 1.07209593282158 0.618421052631579 11.3 11 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000124168735134959 0.000470232452327327 1.07168119551681 0.618181818181818 11.3 11 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.000124168735134959 0.000470232452327327 1.07168119551681 0.618181818181818 11.3 11 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000124168735134959 0.000470232452327327 1.07168119551681 0.618181818181818 11.3 11 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.000124168735134959 0.000470232452327327 1.07168119551681 0.618181818181818 11.3 11 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.17356739782538e-05 6.07267784402004e-05 1.06865872639166 0.616438356164384 11.3 11 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.64308742223444e-52 1.16905670091981e-49 1.066831959338 0.615384615384615 11.3 11 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00841049450760679 0.0194920744044372 1.066831959338 0.615384615384615 11.3 11 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00841049450760679 0.0194920744044372 1.066831959338 0.615384615384615 11.3 11 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00841049450760679 0.0194920744044372 1.066831959338 0.615384615384615 11.3 11 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00841049450760679 0.0194920744044372 1.066831959338 0.615384615384615 11.3 11 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 3.74874620009551e-05 0.000164644007491849 1.066831959338 0.615384615384615 11.3 11 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.98205955260177e-09 2.23846884393041e-08 1.06492690226776 0.614285714285714 11.3 11 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.06580026769159e-05 9.83155110677304e-05 1.06492690226776 0.614285714285714 11.3 11 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.0914465879139e-13 7.08602022524163e-12 1.06492690226776 0.614285714285714 11.3 11 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 6.61086327507786e-05 0.000273466815128947 1.06253021756648 0.612903225806452 11.3 11 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00445189560471258 0.0114557819991067 1.06253021756648 0.612903225806452 11.3 11 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.08620560427799e-07 8.73260211800891e-07 1.06202640997162 0.612612612612613 11.3 11 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00237862007524792 0.0066108913419488 1.05942340406482 0.611111111111111 11.3 11 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0298084029283769 0.0590770993970479 1.05942340406482 0.611111111111111 11.3 11 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0298084029283769 0.0590770993970479 1.05942340406482 0.611111111111111 11.3 11 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0298084029283769 0.0590770993970479 1.05942340406482 0.611111111111111 11.3 11 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.85593735784638e-89 5.4869988602154e-86 1.0587394638427 0.610716591349258 11.3 11 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.07172190648902e-06 7.40320520841687e-06 1.05840960176428 0.610526315789474 11.3 11 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.94889438327965e-07 4.25390789316932e-06 1.0574971796938 0.61 11.3 11 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.04835327460983e-13 3.72951677442447e-12 1.05726395970268 0.609865470852018 11.3 11 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 6.14227443110459e-22 6.72342808881679e-20 1.0568482377934 0.609625668449198 11.3 11 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.30471457950766e-07 2.46209887258607e-06 1.05667165496336 0.60952380952381 11.3 11 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 6.39237566119021e-05 0.000265975162744844 1.05641367848509 0.609375 11.3 11 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0153431989762836 0.0335898032973101 1.05523595977998 0.608695652173913 11.3 11 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.51423503335678e-05 0.000156763525155696 1.05523595977998 0.608695652173913 11.3 11 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.93568008071338e-05 9.24319716394344e-05 1.05421739225124 0.608108108108108 11.3 11 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.93568008071338e-05 9.24319716394344e-05 1.05421739225124 0.608108108108108 11.3 11 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.12358793618074e-15 1.70956370507123e-13 1.05375803826768 0.607843137254902 11.3 11 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.73141660049001e-32 6.47800970416214e-30 1.05351991431124 0.607705779334501 11.3 11 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00803737389778385 0.0187494804205679 1.05254403131115 0.607142857142857 11.3 11 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00803737389778385 0.0187494804205679 1.05254403131115 0.607142857142857 11.3 11 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.26471890086954e-06 2.07397098032918e-05 1.05184836440348 0.606741573033708 11.3 11 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00426159790195029 0.0110116142573265 1.05066783874197 0.606060606060606 11.3 11 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00426159790195029 0.0110116142573265 1.05066783874197 0.606060606060606 11.3 11 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00426159790195029 0.0110116142573265 1.05066783874197 0.606060606060606 11.3 11 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.71742934166608e-07 1.29994784744193e-06 1.04928538105942 0.605263157894737 11.3 11 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.86667211224224e-05 9.09683019082435e-05 1.04928538105942 0.605263157894737 11.3 11 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00227973773589944 0.00636819435594664 1.04928538105942 0.605263157894737 11.3 11 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.02996363126549e-05 5.4082592150952e-05 1.04872215755912 0.604938271604938 11.3 11 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.69122468892113e-06 3.34653418691519e-05 1.0482244251635 0.604651162790698 11.3 11 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00122784288037586 0.00384004487642825 1.0482244251635 0.604651162790698 11.3 11 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.00122784288037586 0.00384004487642825 1.0482244251635 0.604651162790698 11.3 11 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.37962993529525e-42 1.20230334948129e-39 1.04548849024113 0.603072983354674 11.3 11 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 5.47804049819515e-06 3.23454424437e-05 1.04410116474984 0.602272727272727 11.3 11 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000636171072723085 0.00212007362174461 1.04016116035455 0.6 11.3 11 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00764015476323568 0.0179999010398748 1.04016116035455 0.6 11.3 11 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0145351889684908 0.0320786990145007 1.04016116035455 0.6 11.3 11 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0145351889684908 0.0320786990145007 1.04016116035455 0.6 11.3 11 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0556115349683982 0.0979396216089487 1.04016116035455 0.6 11.3 11 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0556115349683982 0.0979396216089487 1.04016116035455 0.6 11.3 11 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.00217611238597797 0.00619321585049332 1.04016116035455 0.6 11.3 11 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0280909137302924 0.0560636328726593 1.04016116035455 0.6 11.3 11 3 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.87436462934853e-14 1.49005969393593e-12 1.03878528580382 0.599206349206349 11.3 11 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.87436462934853e-14 1.49005969393593e-12 1.03878528580382 0.599206349206349 11.3 11 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.87436462934853e-14 1.49005969393593e-12 1.03878528580382 0.599206349206349 11.3 11 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 4.56562014664962e-08 3.73383762567955e-07 1.0375344907577 0.598484848484849 11.3 11 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.44434523826169e-05 0.000230574502203761 1.03534559942699 0.597222222222222 11.3 11 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.67734227299428e-06 1.72391767170627e-05 1.03315670809627 0.595959595959596 11.3 11 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 4.83366819916982e-06 2.9022404419488e-05 1.03278413084849 0.595744680851064 11.3 11 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.88920598887501e-09 4.0396643227512e-08 1.03138342904354 0.594936708860759 11.3 11 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 2.86548293553238e-05 0.000129447054516272 1.03138342904354 0.594936708860759 11.3 11 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000315141664769788 0.00109644642779317 1.02840792690422 0.593220338983051 11.3 11 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0137039290462738 0.0305175133534391 1.02731966454771 0.592592592592593 11.3 11 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0137039290462738 0.0305175133534391 1.02731966454771 0.592592592592593 11.3 11 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00106259864214965 0.00335272254496441 1.02600930783272 0.591836734693878 11.3 11 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00196327394870835 0.00564391682628684 1.02440114277342 0.590909090909091 11.3 11 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0263308867649317 0.0533744328582591 1.02440114277342 0.590909090909091 11.3 11 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 2.6061207348804e-05 0.000118482741397278 1.02345174412396 0.590361445783133 11.3 11 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00364701446551244 0.0096452942710381 1.02238062769892 0.58974358974359 11.3 11 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 6.00675636073938e-08 4.8565990348478e-07 1.02048908167172 0.588652482269504 11.3 11 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.16179241617444e-13 7.15402467027031e-12 1.02015806111697 0.588461538461538 11.3 11 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.93480494150399e-10 6.10628472326972e-09 1.01976584348486 0.588235294117647 11.3 11 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 2.47969962125525e-05 0.000114565342891111 1.01976584348486 0.588235294117647 11.3 11 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 2.47969962125525e-05 0.000114565342891111 1.01976584348486 0.588235294117647 11.3 11 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0068211800181456 0.0161238192123276 1.01976584348486 0.588235294117647 11.3 11 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0068211800181456 0.0161238192123276 1.01976584348486 0.588235294117647 11.3 11 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0068211800181456 0.0161238192123276 1.01976584348486 0.588235294117647 11.3 11 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0516383982518129 0.0912812928103476 1.01976584348486 0.588235294117647 11.3 11 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0516383982518129 0.0912812928103476 1.01976584348486 0.588235294117647 11.3 11 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00185725813366494 0.0054046591497039 1.01754896121641 0.58695652173913 11.3 11 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0128719560665028 0.0287547778377292 1.0162494095418 0.586206896551724 11.3 11 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00344133310852572 0.00915330282884505 1.01479137595566 0.585365853658537 11.3 11 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 4.5670717683831e-25 6.49894312640916e-23 1.01289101757372 0.584269662921348 11.3 11 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00175305414786304 0.00511187715657605 1.01126779478915 0.583333333333333 11.3 11 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0245846089844397 0.0500484958295533 1.01126779478915 0.583333333333333 11.3 11 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00641560774957292 0.015720904137326 1.01126779478915 0.583333333333333 11.3 11 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00641560774957292 0.015720904137326 1.01126779478915 0.583333333333333 11.3 11 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.92257730181283e-09 4.04480253657946e-08 1.008819204487 0.581920903954802 11.3 11 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00323972338309472 0.00864939282203336 1.00790810111875 0.581395348837209 11.3 11 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0120546674442677 0.0269713707125674 1.00660757453666 0.580645161290323 11.3 11 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.42059546725872e-07 1.12305963883842e-06 1.00621650710289 0.58041958041958 11.3 11 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.61899442917185e-05 0.000160932158522236 1.00470112079701 0.579545454545455 11.3 11 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0477715029556248 0.087064780056484 1.00366427753509 0.578947368421053 11.3 11 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0477715029556248 0.087064780056484 1.00366427753509 0.578947368421053 11.3 11 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.89758936225341e-05 9.15345648300542e-05 1.00366427753509 0.578947368421053 11.3 11 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.89758936225341e-05 9.15345648300542e-05 1.00366427753509 0.578947368421053 11.3 11 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.000437715874228003 0.00147364980970131 1.00223861804996 0.578125 11.3 11 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00155311967389313 0.00461396512724409 1.00015496187938 0.576923076923077 11.3 11 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0228870450515144 0.0467934843510128 1.00015496187938 0.576923076923077 11.3 11 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0228870450515144 0.0467934843510128 1.00015496187938 0.576923076923077 11.3 11 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0228870450515144 0.0467934843510128 1.00015496187938 0.576923076923077 11.3 11 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0112623885968075 0.0254386967829477 0.998134446804874 0.575757575757576 11.3 11 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0112623885968075 0.0254386967829477 0.998134446804874 0.575757575757576 11.3 11 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.81333226647706e-05 0.000244022767409937 0.996322950531181 0.574712643678161 11.3 11 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 4.03163514928606e-09 4.12735022836983e-08 0.993209441310771 0.572916666666667 11.3 11 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.010501822345162 0.0237963267470789 0.990629676528145 0.571428571428571 11.3 11 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0212593359109271 0.0437168135856203 0.990629676528145 0.571428571428571 11.3 11 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.68438094369638e-14 1.49005969393593e-12 0.989110305858624 0.570552147239264 11.3 11 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.17839840395319e-18 9.31589404902997e-17 0.987297962369419 0.569506726457399 11.3 11 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000660155534041112 0.00219486290873949 0.986819562387653 0.569230769230769 11.3 11 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00977707633398432 0.0221894411854222 0.98393623276782 0.567567567567568 11.3 11 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0197135423861598 0.0405967739732349 0.982374429223744 0.566666666666667 11.3 11 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0197135423861598 0.0405967739732349 0.982374429223744 0.566666666666667 11.3 11 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00458641920841599 0.0117403081292185 0.97986196265284 0.565217391304348 11.3 11 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0406148808901742 0.0751560149632223 0.97986196265284 0.565217391304348 11.3 11 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00427154678147872 0.0110116142573265 0.975151087832393 0.5625 11.3 11 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00427154678147872 0.0110116142573265 0.975151087832393 0.5625 11.3 11 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00427154678147872 0.0110116142573265 0.975151087832393 0.5625 11.3 11 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00397462635345582 0.0104352274925602 0.970817082997583 0.56 11.3 11 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0373747799138293 0.0695219762318681 0.970817082997583 0.56 11.3 11 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.67488916166377e-11 5.33608905821178e-10 0.97006606410924 0.55956678700361 11.3 11 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000848769711469795 0.00274499840777618 0.965863934614942 0.557142857142857 11.3 11 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000848769711469795 0.00274499840777618 0.965863934614942 0.557142857142857 11.3 11 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0343659400580651 0.0640927034110442 0.963112185513475 0.555555555555556 11.3 11 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.23213719286214e-06 8.47019915672866e-06 0.961869460112812 0.554838709677419 11.3 11 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 2.54938412264969e-22 3.02314467210876e-20 0.957120818885086 0.552099533437014 11.3 11 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.08896427884625e-17 1.35118007672646e-15 0.956107733255195 0.551515151515152 11.3 11 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0718255564532533 0.117076479762863 0.95348106365834 0.55 11.3 11 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 7.35313166473568e-17 4.3597943162162e-15 0.951366914958432 0.548780487804878 11.3 11 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0290136048156001 0.0577431603532853 0.950684931506849 0.548387096774194 11.3 11 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0290136048156001 0.0577431603532853 0.950684931506849 0.548387096774194 11.3 11 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00218506419096842 0.00620628012724164 0.945601054867775 0.545454545454545 11.3 11 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0266477070756604 0.0539398110507322 0.945601054867775 0.545454545454545 11.3 11 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.176748012875767 0.244661889418499 0.945601054867775 0.545454545454545 11.3 11 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.176748012875767 0.244661889418499 0.945601054867775 0.545454545454545 11.3 11 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.176748012875767 0.244661889418499 0.945601054867775 0.545454545454545 11.3 11 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.176748012875767 0.244661889418499 0.945601054867775 0.545454545454545 11.3 11 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0244714097906789 0.049889421392745 0.941098192701738 0.542857142857143 11.3 11 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0595597476878605 0.103737479754988 0.939034380875638 0.541666666666667 11.3 11 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0595597476878605 0.103737479754988 0.939034380875638 0.541666666666667 11.3 11 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0595597476878605 0.103737479754988 0.939034380875638 0.541666666666667 11.3 11 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0595597476878605 0.103737479754988 0.939034380875638 0.541666666666667 11.3 11 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 5.32155669301398e-06 3.15523965589954e-05 0.938574295436698 0.54140127388535 11.3 11 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.19887869288522e-30 5.86931898047976e-28 0.937082126445543 0.540540540540541 11.3 11 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0494889448432242 0.0879185624368391 0.928715321745136 0.535714285714286 11.3 11 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.045146519309143 0.0829026599475024 0.924587698092936 0.533333333333333 11.3 11 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.045146519309143 0.0829026599475024 0.924587698092936 0.533333333333333 11.3 11 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.140746017679372 0.201173535962805 0.924587698092936 0.533333333333333 11.3 11 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.140746017679372 0.201173535962805 0.924587698092936 0.533333333333333 11.3 11 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0412058797380957 0.076150606321182 0.92097602739726 0.53125 11.3 11 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0376274681397767 0.069900635982901 0.91778925913637 0.529411764705882 11.3 11 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.126248273607807 0.192346138483843 0.91778925913637 0.529411764705882 11.3 11 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.126248273607807 0.192346138483843 0.91778925913637 0.529411764705882 11.3 11 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.126248273607807 0.192346138483843 0.91778925913637 0.529411764705882 11.3 11 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00108964823206328 0.00343046335005763 0.913403169486973 0.526881720430108 11.3 11 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.113541880684423 0.176966151384374 0.91242207048645 0.526315789473684 11.3 11 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.0262793744960097 0.0533460055746388 0.908077203484133 0.523809523809524 11.3 11 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0262793744960097 0.0533460055746388 0.908077203484133 0.523809523809524 11.3 11 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.102340092818667 0.161811057867738 0.908077203484133 0.523809523809524 11.3 11 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000622320385156105 0.00207878382177732 0.90730568504447 0.523364485981308 11.3 11 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00188284352925186 0.00546793131045999 0.906201010914951 0.522727272727273 11.3 11 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0169210741437094 0.0362033444654926 0.90013946569144 0.519230769230769 11.3 11 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0757199650018003 0.122862190343602 0.898904706479243 0.518518518518518 11.3 11 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0686746733000161 0.112197543175572 0.896690655478063 0.517241379310345 11.3 11 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0623549614355885 0.106135696490353 0.894762288477035 0.516129032258065 11.3 11 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00335860575426855 0.00894999248749841 0.886063210672397 0.511111111111111 11.3 11 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0324817334538122 0.0625639780400896 0.886063210672397 0.511111111111111 11.3 11 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00673242001743253 0.0159937123285584 0.877502213467833 0.506172839506173 11.3 11 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00673242001743253 0.0159937123285584 0.877502213467833 0.506172839506173 11.3 11 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000117948324836313 0.000454852212038139 0.876880047973315 0.505813953488372 11.3 11 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.37881905058213e-05 6.93307246988825e-05 0.870521142785999 0.502145922746781 11.3 11 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0517171613974447 0.0913070976036771 0.866800966962127 0.5 11.3 11 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0922028272908891 0.147255469399478 0.866800966962127 0.5 11.3 11 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.101950985160376 0.161375141138171 0.866800966962127 0.5 11.3 11 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.112909788299592 0.176173935033245 0.866800966962127 0.5 11.3 11 3 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.219479112131356 0.297163441068429 0.866800966962127 0.5 11.3 11 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.219479112131356 0.297163441068429 0.866800966962127 0.5 11.3 11 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.219479112131356 0.297163441068429 0.866800966962127 0.5 11.3 11 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.219479112131356 0.297163441068429 0.866800966962127 0.5 11.3 11 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.248781126410939 0.331475227418321 0.866800966962127 0.5 11.3 11 3 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.248781126410939 0.331475227418321 0.866800966962127 0.5 11.3 11 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00163912654812683 0.00485932724580101 0.866800966962127 0.5 11.3 11 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0757204082440893 0.122862190343602 0.866800966962127 0.5 11.3 11 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0757204082440893 0.122862190343602 0.866800966962127 0.5 11.3 11 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0835040431330815 0.134876564561152 0.866800966962127 0.5 11.3 11 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.155258204915592 0.218312673512735 0.866800966962127 0.5 11.3 11 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.155258204915592 0.218312673512735 0.866800966962127 0.5 11.3 11 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.155258204915592 0.218312673512735 0.866800966962127 0.5 11.3 11 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.155258204915592 0.218312673512735 0.866800966962127 0.5 11.3 11 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.19474310752764 0.26878704365842 0.866800966962127 0.5 11.3 11 3 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.038605027508635 0.0716231475160204 0.851040949380998 0.490909090909091 11.3 11 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00728933105807991 0.017201854221638 0.849464947622885 0.49 11.3 11 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0507613054429782 0.0900665057922169 0.849111151309839 0.489795918367347 11.3 11 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0737806946449238 0.120125776292593 0.845659479963051 0.48780487804878 11.3 11 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0811723308860012 0.131259348694068 0.844575301142586 0.487179487179487 11.3 11 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0811723308860012 0.131259348694068 0.844575301142586 0.487179487179487 11.3 11 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0893892461458925 0.142922356478208 0.843373913800989 0.486486486486487 11.3 11 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.108755906607104 0.170065555057043 0.840534270993578 0.484848484848485 11.3 11 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.108755906607104 0.170065555057043 0.840534270993578 0.484848484848485 11.3 11 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.108755906607104 0.170065555057043 0.840534270993578 0.484848484848485 11.3 11 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.133008876230046 0.197126603728779 0.836911278446192 0.482758620689655 11.3 11 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.147443195647541 0.208146495442908 0.834697227445012 0.481481481481481 11.3 11 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.163751078433022 0.228001746193924 0.832128928283642 0.48 11.3 11 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.163751078433022 0.228001746193924 0.832128928283642 0.48 11.3 11 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.163751078433022 0.228001746193924 0.832128928283642 0.48 11.3 11 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0708551993357211 0.115627234695793 0.830684260005372 0.479166666666667 11.3 11 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.00104288710173162 0.00329784076836465 0.829519204942251 0.478494623655914 11.3 11 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0777554276379236 0.126020470989482 0.829113968398557 0.478260869565217 11.3 11 3 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.182256568526158 0.25204188242247 0.829113968398557 0.478260869565217 11.3 11 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.20336557954916 0.277458504025364 0.825524730440121 0.476190476190476 11.3 11 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.20336557954916 0.277458504025364 0.825524730440121 0.476190476190476 11.3 11 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0515482335958021 0.0912812928103476 0.824171411209892 0.475409836065574 11.3 11 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.034698069781675 0.0646274257844549 0.821179863437805 0.473684210526316 11.3 11 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.22759655152208 0.304103185742648 0.821179863437805 0.473684210526316 11.3 11 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.067449018899894 0.110321786085689 0.819520914218739 0.472727272727273 11.3 11 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.255627404345269 0.339643133877981 0.815812674787884 0.470588235294118 11.3 11 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0886305670100707 0.141868725371575 0.813731520005262 0.469387755102041 11.3 11 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00221812007240154 0.00628761924905855 0.809600903152444 0.467005076142132 11.3 11 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.288370569776841 0.374408139409165 0.809014235831319 0.466666666666667 11.3 11 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.288370569776841 0.374408139409165 0.809014235831319 0.466666666666667 11.3 11 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.106630220645761 0.167293058411155 0.809014235831319 0.466666666666667 11.3 11 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.327099203749655 0.412432143113493 0.800123969503502 0.461538461538462 11.3 11 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.327099203749655 0.412432143113493 0.800123969503502 0.461538461538462 11.3 11 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.230471384040887 0.307655515469215 0.794567553048617 0.458333333333333 11.3 11 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.171451133823488 0.238290950701047 0.792503741222516 0.457142857142857 11.3 11 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.11081476249045 0.173094848544359 0.788000879056479 0.454545454545455 11.3 11 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.189046781961569 0.261178224010983 0.788000879056479 0.454545454545455 11.3 11 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.25676181393269 0.340832146666248 0.788000879056479 0.454545454545455 11.3 11 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.37367336388893 0.454476236593118 0.788000879056479 0.454545454545455 11.3 11 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.37367336388893 0.454476236593118 0.788000879056479 0.454545454545455 11.3 11 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.37367336388893 0.454476236593118 0.788000879056479 0.454545454545455 11.3 11 3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.37367336388893 0.454476236593118 0.788000879056479 0.454545454545455 11.3 11 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.208679201128398 0.284163160962402 0.782917002417405 0.451612903225806 11.3 11 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.208679201128398 0.284163160962402 0.782917002417405 0.451612903225806 11.3 11 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.087610915659125 0.140394519124927 0.781341716698256 0.450704225352113 11.3 11 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.286782471472844 0.373026925873726 0.780120870265915 0.45 11.3 11 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.122483172842765 0.189243816455217 0.77048974841078 0.444444444444444 11.3 11 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.145005477641703 0.2049084356347 0.77048974841078 0.444444444444444 11.3 11 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.321272803973879 0.40673594310928 0.77048974841078 0.444444444444444 11.3 11 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.321272803973879 0.40673594310928 0.77048974841078 0.444444444444444 11.3 11 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.158128272552106 0.220820934093863 0.76678547077419 0.442307692307692 11.3 11 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.048803691639137 0.087064780056484 0.764422899998097 0.440944881889764 11.3 11 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.157623949051323 0.22033288752459 0.760351725405375 0.43859649122807 11.3 11 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.25233452348448 0.335581333568612 0.758450846091861 0.4375 11.3 11 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.361191929303998 0.446652550018126 0.758450846091861 0.4375 11.3 11 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.361191929303998 0.446652550018126 0.758450846091861 0.4375 11.3 11 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.361191929303998 0.446652550018126 0.758450846091861 0.4375 11.3 11 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.361191929303998 0.446652550018126 0.758450846091861 0.4375 11.3 11 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.171475708726544 0.238290950701047 0.75648084389422 0.436363636363636 11.3 11 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0392790037426292 0.0727786749033352 0.755127222752283 0.43558282208589 11.3 11 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.042116874371767 0.0777332194954922 0.753739971271415 0.434782608695652 11.3 11 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.143581035732555 0.203097230464638 0.753739971271415 0.434782608695652 11.3 11 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.045150781067684 0.0829026599475024 0.752317820382224 0.433962264150943 11.3 11 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.045150781067684 0.0829026599475024 0.752317820382224 0.433962264150943 11.3 11 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.277980507456579 0.363906404885659 0.75122750470051 0.433333333333333 11.3 11 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0481753276416749 0.087064780056484 0.749087255399369 0.432098765432099 11.3 11 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0217188759858509 0.0445973456390559 0.744961473614037 0.429718875502008 11.3 11 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.349345140415607 0.437603991911452 0.742972257396109 0.428571428571429 11.3 11 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.024348930386076 0.049710943958947 0.741029846265662 0.427450980392157 11.3 11 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.197495380271871 0.272321633843869 0.73891229970542 0.426229508196721 11.3 11 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.338308927706829 0.424526987766153 0.733446972044877 0.423076923076923 11.3 11 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.389400987575188 0.467609793518559 0.72993765638916 0.421052631578947 11.3 11 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.389400987575188 0.467609793518559 0.72993765638916 0.421052631578947 11.3 11 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0969837793991823 0.153683650428771 0.726994359387591 0.419354838709677 11.3 11 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.435087096775109 0.517233866926466 0.713836090439399 0.411764705882353 11.3 11 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.316591881356973 0.401524284466107 0.707592626091533 0.408163265306122 11.3 11 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.365985153423144 0.446652550018126 0.702811594834157 0.405405405405405 11.3 11 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.342064047227377 0.428860915598729 0.700817803075762 0.404255319148936 11.3 11 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.217113677446166 0.29508382331031 0.695971579312657 0.401459854014599 11.3 11 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.21249300512895 0.289079872178294 0.695882466434384 0.401408450704225 11.3 11 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.224601793148513 0.303186111923749 0.693440773569702 0.4 11.3 11 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.487443407587738 0.571831796370446 0.693440773569702 0.4 11.3 11 3 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.487443407587738 0.571831796370446 0.693440773569702 0.4 11.3 11 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.272898878044508 0.357582968192757 0.69023039961799 0.398148148148148 11.3 11 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.250500809789149 0.333454305266566 0.688341944352277 0.397058823529412 11.3 11 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.272222558542415 0.357025530696642 0.683317550597881 0.394160583941606 11.3 11 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.507514374012254 0.592933459950277 0.674178529859432 0.388888888888889 11.3 11 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.494434102925869 0.57955496578543 0.666769974586252 0.384615384615385 11.3 11 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.547746418191502 0.636799961671983 0.666769974586252 0.384615384615385 11.3 11 3 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.547746418191502 0.636799961671983 0.666769974586252 0.384615384615385 11.3 11 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.330854215098492 0.415538877392016 0.665328309776336 0.383783783783784 11.3 11 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.482197118818292 0.566611478182022 0.654189409028021 0.377358490566038 11.3 11 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.576413849433877 0.669581149179107 0.638695449340515 0.368421052631579 11.3 11 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.581251562765643 0.674650060208409 0.625233484366125 0.360655737704918 11.3 11 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.598531756863793 0.677239403844843 0.624096696212732 0.36 11.3 11 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.598531756863793 0.677239403844843 0.624096696212732 0.36 11.3 11 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.781220049374005 0.848607733022297 0.62071405829288 0.358048780487805 11.3 11 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.625486499151569 0.698639943714822 0.619143547830091 0.357142857142857 11.3 11 3 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.625486499151569 0.698639943714822 0.619143547830091 0.357142857142857 11.3 11 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.625486499151569 0.698639943714822 0.619143547830091 0.357142857142857 11.3 11 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.618985894526236 0.693556636150262 0.616391798728624 0.355555555555556 11.3 11 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.625091844575369 0.698639943714822 0.611859506090913 0.352941176470588 11.3 11 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.766329414493864 0.83690464836897 0.591961635974136 0.341463414634146 11.3 11 3 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.694508044933485 0.774910560033956 0.577867311308085 0.333333333333333 11.3 11 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.710943739904025 0.78729411819722 0.577867311308085 0.333333333333333 11.3 11 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.799027439423838 0.865968047448684 0.571909916346146 0.329896907216495 11.3 11 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.750614532608209 0.821002674789763 0.559226430298147 0.32258064516129 11.3 11 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.750614532608209 0.821002674789763 0.559226430298147 0.32258064516129 11.3 11 3 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.749168074239432 0.820682193720332 0.554752618855761 0.32 11.3 11 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.848424435056801 0.908433386821541 0.548608206938055 0.316455696202532 11.3 11 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.884758802502246 0.941669241556242 0.542845050016686 0.313131313131313 11.3 11 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.754196113285987 0.824286535488448 0.54175060435133 0.3125 11.3 11 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.910343086714548 0.963852836603275 0.533415979669001 0.307692307692308 11.3 11 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.825375688875029 0.89316319792332 0.520080580177276 0.3 11.3 11 3 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.855959798256909 0.914437532221908 0.503303787268332 0.290322580645161 11.3 11 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.875373925650589 0.933076476554898 0.501832138767547 0.289473684210526 11.3 11 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.878387205338314 0.9355875697578 0.495314838264073 0.285714285714286 11.3 11 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.912239387026698 0.965142489025272 0.483795888537001 0.27906976744186 11.3 11 3 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.871914522755395 0.930085731544923 0.472800527433888 0.272727272727273 11.3 11 3 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.871914522755395 0.930085731544923 0.472800527433888 0.272727272727273 11.3 11 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.956477509084848 1 0.457932586319614 0.264150943396226 11.3 11 3 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.943708646146778 0.995476207165949 0.454038601742067 0.261904761904762 11.3 11 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.938035273636939 0.990225663490627 0.445783354437665 0.257142857142857 11.3 11 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.908048215025393 0.962138950097643 0.433400483481064 0.25 11.3 11 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.959338214818863 1 0.404507117915659 0.233333333333333 11.3 11 3 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.959978838850176 1 0.376869985635708 0.217391304347826 11.3 11 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999999973211 1 0.370847836380704 0.213917525773196 11.3 11 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.97010189284667 1 0.361167069567553 0.208333333333333 11.3 11 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999999867969505 1 0.359502705191666 0.207373271889401 11.3 11 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999997439788 1 0.359103257741453 0.207142857142857 11.3 11 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.997838489495688 1 0.325050362610798 0.1875 11.3 11 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.991217836353247 1 0.309571773915045 0.178571428571429 11.3 11 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999990540786 1 0.305350340634386 0.176136363636364 11.3 11 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.296939374072668 0.171284634760705 11.3 11 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.996671057908719 1 0.279613215149073 0.161290322580645 11.3 11 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.257062131250974 0.148282097649186 11.3 11 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999957235491866 1 0.216700241740532 0.125 11.3 11 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0251651893634166 0.0145161290322581 11.3 11 3 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.000220775430266384 0.00270830549369883 4.383907316299 1 11.1 11 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 5.09656873252146e-05 0.000771533755997663 3.83591890176163 0.875 11.1 11 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 5.09656873252146e-05 0.000771533755997663 3.83591890176163 0.875 11.1 11 1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.000241226241063347 0.00290902492400968 3.757634842542 0.857142857142857 11.1 11 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 2.21702746613508e-06 5.53478962159688e-05 3.65325609691583 0.833333333333333 11.1 11 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.000812007902277744 0.00717693940957286 3.28793048722425 0.75 11.1 11 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.000135810740116974 0.00180615591763041 3.18829623003564 0.727272727272727 11.1 11 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 2.32805727275561e-05 0.000394383987991814 3.131362368785 0.714285714285714 11.1 11 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00331606766473055 0.0186512422407572 3.131362368785 0.714285714285714 11.1 11 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00331606766473055 0.0186512422407572 3.131362368785 0.714285714285714 11.1 11 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.000537338249698997 0.00509754886214448 3.0687351214093 0.7 11.1 11 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000537338249698997 0.00509754886214448 3.0687351214093 0.7 11.1 11 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 5.81457009305e-05 0.000853003427052593 2.92260487753267 0.666666666666667 11.1 11 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.000340742149889052 0.00377211417459651 2.92260487753267 0.666666666666667 11.1 11 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.00124001139146754 0.00958987070683865 2.78975920128118 0.636363636363636 11.1 11 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 4.53910023493074e-07 1.26649796751107e-05 2.76023793989196 0.62962962962963 11.1 11 1 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.00748950060215189 0.0330980104250377 2.73994207268688 0.625 11.1 11 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00748950060215189 0.0330980104250377 2.73994207268688 0.625 11.1 11 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00432295491847395 0.0226317852855407 2.6303443897794 0.6 11.1 11 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000261299002293943 0.00307296264681224 2.57876900958765 0.588235294117647 11.1 11 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00249898832967742 0.0150044742326201 2.55727926784108 0.583333333333333 11.1 11 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.000154702453570773 0.00198325758046135 2.53805160417311 0.578947368421053 11.1 11 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000841364248766803 0.00725612924845552 2.46594786541819 0.5625 11.1 11 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000167325125587376 0.00211049465575694 2.39122217252673 0.545454545454545 11.1 11 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00802248715088164 0.0345554642485167 2.39122217252673 0.545454545454545 11.1 11 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00802248715088164 0.0345554642485167 2.39122217252673 0.545454545454545 11.1 11 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00802248715088164 0.0345554642485167 2.39122217252673 0.545454545454545 11.1 11 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00802248715088164 0.0345554642485167 2.39122217252673 0.545454545454545 11.1 11 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.83212299965372e-08 1.93002582058308e-06 2.38255832407554 0.543478260869565 11.1 11 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.00454961495620966 0.0226317852855407 2.36056547800715 0.538461538461538 11.1 11 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00454961495620966 0.0226317852855407 2.36056547800715 0.538461538461538 11.1 11 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00454961495620966 0.0226317852855407 2.36056547800715 0.538461538461538 11.1 11 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00259946522799586 0.0154771507089461 2.33808390202613 0.533333333333333 11.1 11 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00149393765104877 0.0110148874478881 2.32089210862888 0.529411764705882 11.1 11 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000500025738529934 0.00484038521039522 2.29633240377567 0.523809523809524 11.1 11 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000169561636684571 0.00211654569300127 2.27963180447548 0.52 11.1 11 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000832726351472492 0.00722542437893509 2.1919536581495 0.5 11.1 11 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000832726351472492 0.00722542437893509 2.1919536581495 0.5 11.1 11 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00435756620722492 0.0226317852855407 2.1919536581495 0.5 11.1 11 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00435756620722492 0.0226317852855407 2.1919536581495 0.5 11.1 11 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0242508354981871 0.0810068988589678 2.1919536581495 0.5 11.1 11 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0242508354981871 0.0810068988589678 2.1919536581495 0.5 11.1 11 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0242508354981871 0.0810068988589678 2.1919536581495 0.5 11.1 11 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.44651817512022e-08 1.19619399102343e-06 2.15716074294078 0.492063492063492 11.1 11 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 5.32495974217834e-05 0.000794777746514719 2.1293264107738 0.485714285714286 11.1 11 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 2.30560611531286e-09 9.11354861691724e-08 2.10871491163749 0.481012658227848 11.1 11 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00132951032965603 0.0101170759310189 2.09665132518648 0.478260869565217 11.1 11 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00132951032965603 0.0101170759310189 2.09665132518648 0.478260869565217 11.1 11 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00229299170269962 0.0145666392542034 2.08757491252333 0.476190476190476 11.1 11 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.90569668635878e-05 0.000475265101688338 2.08235597524203 0.475 11.1 11 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0039695313055596 0.0212355001797418 2.07658767614163 0.473684210526316 11.1 11 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000240923425981981 0.00290902492400968 2.05495655451516 0.46875 11.1 11 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.78150511350958e-06 4.5269317437931e-05 2.03538553971025 0.464285714285714 11.1 11 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00119478719516153 0.00934166032260912 2.02334183829185 0.461538461538462 11.1 11 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0212571611285512 0.0734197579755542 2.02334183829185 0.461538461538462 11.1 11 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0212571611285512 0.0734197579755542 2.02334183829185 0.461538461538462 11.1 11 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0212571611285512 0.0734197579755542 2.02334183829185 0.461538461538462 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00204535977293858 0.0132901687529297 2.00929085330371 0.458333333333333 11.1 11 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00204535977293858 0.0132901687529297 2.00929085330371 0.458333333333333 11.1 11 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00204535977293858 0.0132901687529297 2.00929085330371 0.458333333333333 11.1 11 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 4.01318056593654e-05 0.000634528438369745 1.99268514377227 0.454545454545455 11.1 11 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 4.01318056593654e-05 0.000634528438369745 1.99268514377227 0.454545454545455 11.1 11 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000366185587512018 0.00400832377715079 1.99268514377227 0.454545454545455 11.1 11 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0377744591209418 0.108373095421573 1.99268514377227 0.454545454545455 11.1 11 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0377744591209418 0.108373095421573 1.99268514377227 0.454545454545455 11.1 11 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0377744591209418 0.108373095421573 1.99268514377227 0.454545454545455 11.1 11 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.74768396507917e-17 8.28984760769221e-15 1.98645800269798 0.453125 11.1 11 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00603980369393971 0.0283651506814396 1.97275829233455 0.45 11.1 11 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00603980369393971 0.0283651506814396 1.97275829233455 0.45 11.1 11 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00603980369393971 0.0283651506814396 1.97275829233455 0.45 11.1 11 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00603980369393971 0.0283651506814396 1.97275829233455 0.45 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00105344457655082 0.0086152392668495 1.96519983144438 0.448275862068966 11.1 11 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.8788096407521e-08 1.02413652969756e-06 1.95986444728661 0.447058823529412 11.1 11 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.19323994151229e-11 1.86468138649125e-09 1.9564545047946 0.446280991735537 11.1 11 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.19323994151229e-11 1.86468138649125e-09 1.9564545047946 0.446280991735537 11.1 11 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.19323994151229e-11 1.86468138649125e-09 1.9564545047946 0.446280991735537 11.1 11 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00178982064227234 0.0121281655902549 1.94840325168844 0.444444444444444 11.1 11 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0104271528784711 0.0426374670863918 1.94840325168844 0.444444444444444 11.1 11 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0104271528784711 0.0426374670863918 1.94840325168844 0.444444444444444 11.1 11 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0104271528784711 0.0426374670863918 1.94840325168844 0.444444444444444 11.1 11 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0104271528784711 0.0426374670863918 1.94840325168844 0.444444444444444 11.1 11 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.72947423571394e-11 1.83001442669687e-09 1.94447501932617 0.443548387096774 11.1 11 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.70341590323367e-15 6.05990207575379e-13 1.92987224250119 0.440217391304348 11.1 11 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00304483401460895 0.0172621466246555 1.92891921917156 0.44 11.1 11 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000167593742867557 0.00211049465575694 1.92464223642395 0.439024390243902 11.1 11 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.000916187491287553 0.00776032619108445 1.91795945088081 0.4375 11.1 11 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0180707910891684 0.0651005967592065 1.91795945088081 0.4375 11.1 11 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0180707910891684 0.0651005967592065 1.91795945088081 0.4375 11.1 11 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00518708654595266 0.0249365680908467 1.90604665926043 0.434782608695652 11.1 11 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00518708654595266 0.0249365680908467 1.90604665926043 0.434782608695652 11.1 11 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.00154537244341969 0.0112535139993813 1.89969317039623 0.433333333333333 11.1 11 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00154537244341969 0.0112535139993813 1.89969317039623 0.433333333333333 11.1 11 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 2.86885179156967e-08 1.02413652969756e-06 1.89200210492904 0.431578947368421 11.1 11 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.55219360919888e-05 0.00108553247534243 1.878817421271 0.428571428571429 11.1 11 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000788770210571345 0.0070151250602689 1.878817421271 0.428571428571429 11.1 11 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000788770210571345 0.0070151250602689 1.878817421271 0.428571428571429 11.1 11 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00884991268736979 0.0372586560772995 1.878817421271 0.428571428571429 11.1 11 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.000125441283652988 0.00170002806322097 1.86549247502085 0.425531914893617 11.1 11 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000404476571142497 0.00436038000557404 1.86316060942708 0.425 11.1 11 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00440153501553708 0.0226317852855407 1.85473001843419 0.423076923076923 11.1 11 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00440153501553708 0.0226317852855407 1.85473001843419 0.423076923076923 11.1 11 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.000208218889613543 0.00257648243408758 1.85098308910402 0.422222222222222 11.1 11 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000673862317903038 0.00622666284659755 1.84585571212589 0.421052631578947 11.1 11 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0151236049314976 0.0564852751116039 1.84585571212589 0.421052631578947 11.1 11 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00221314848503877 0.0141860824063521 1.83841274554474 0.419354838709677 11.1 11 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00221314848503877 0.0141860824063521 1.83841274554474 0.419354838709677 11.1 11 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00112187376050377 0.00901935797286361 1.82662804845792 0.416666666666667 11.1 11 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.00112187376050377 0.00901935797286361 1.82662804845792 0.416666666666667 11.1 11 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00743117709810559 0.0330455156581383 1.82662804845792 0.416666666666667 11.1 11 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00743117709810559 0.0330455156581383 1.82662804845792 0.416666666666667 11.1 11 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00743117709810559 0.0330455156581383 1.82662804845792 0.416666666666667 11.1 11 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0550805113701246 0.146754204699144 1.82662804845792 0.416666666666667 11.1 11 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0550805113701246 0.146754204699144 1.82662804845792 0.416666666666667 11.1 11 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0550805113701246 0.146754204699144 1.82662804845792 0.416666666666667 11.1 11 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0550805113701246 0.146754204699144 1.82662804845792 0.416666666666667 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000572268574503908 0.00535748803630961 1.81771766773373 0.414634146341463 11.1 11 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000572268574503908 0.00535748803630961 1.81771766773373 0.414634146341463 11.1 11 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00370472380178859 0.0199690226134286 1.81403061364097 0.413793103448276 11.1 11 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00370472380178859 0.0199690226134286 1.81403061364097 0.413793103448276 11.1 11 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0258882351826858 0.083915623382601 1.80513830671135 0.411764705882353 11.1 11 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0258882351826858 0.083915623382601 1.80513830671135 0.411764705882353 11.1 11 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0258882351826858 0.083915623382601 1.80513830671135 0.411764705882353 11.1 11 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0258882351826858 0.083915623382601 1.80513830671135 0.411764705882353 11.1 11 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00094724165390127 0.007924180012876 1.79852607848164 0.41025641025641 11.1 11 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0125468587433566 0.050578413574494 1.79341662939505 0.409090909090909 11.1 11 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0125468587433566 0.050578413574494 1.79341662939505 0.409090909090909 11.1 11 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.000248188198757865 0.00296783030951631 1.78934992502 0.408163265306122 11.1 11 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00619708864715657 0.0290080827134993 1.78603631404774 0.407407407407407 11.1 11 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00156584383125614 0.0112535139993813 1.77725972282392 0.405405405405405 11.1 11 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00156584383125614 0.0112535139993813 1.77725972282392 0.405405405405405 11.1 11 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.09414826746359e-09 8.51420852743056e-08 1.76617848714204 0.402877697841727 11.1 11 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0211794724232028 0.0734197579755542 1.7535629265196 0.4 11.1 11 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0211794724232028 0.0734197579755542 1.7535629265196 0.4 11.1 11 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0211794724232028 0.0734197579755542 1.7535629265196 0.4 11.1 11 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0211794724232028 0.0734197579755542 1.7535629265196 0.4 11.1 11 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.000341955536558643 0.00377211417459651 1.7535629265196 0.4 11.1 11 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00514429137403453 0.0248990701539154 1.7535629265196 0.4 11.1 11 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0103554058204366 0.0426374670863918 1.7535629265196 0.4 11.1 11 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0103554058204366 0.0426374670863918 1.7535629265196 0.4 11.1 11 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0103554058204366 0.0426374670863918 1.7535629265196 0.4 11.1 11 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0443886916375192 0.123610779256732 1.7535629265196 0.4 11.1 11 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0443886916375192 0.123610779256732 1.7535629265196 0.4 11.1 11 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.62894069199782e-05 0.00108559826047129 1.73964576043611 0.396825396825397 11.1 11 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00214757090518209 0.013890879082155 1.73048973011803 0.394736842105263 11.1 11 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.96411746896129e-07 8.60803909863656e-06 1.72943132661337 0.394495412844037 11.1 11 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00425695186737735 0.0225835899404698 1.7269937912693 0.393939393939394 11.1 11 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000123543651195972 0.00169040976588334 1.72481599329797 0.39344262295082 11.1 11 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000123543651195972 0.00169040976588334 1.72481599329797 0.39344262295082 11.1 11 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00851967129097761 0.0362128476240024 1.72224930283175 0.392857142857143 11.1 11 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.017278140870259 0.0625618179602509 1.71544199333439 0.391304347826087 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0035149480022179 0.0195381679967034 1.70485284522739 0.388888888888889 11.1 11 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0035149480022179 0.0195381679967034 1.70485284522739 0.388888888888889 11.1 11 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0140765750734989 0.0537837351361227 1.68611819857654 0.384615384615385 11.1 11 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.0140765750734989 0.0537837351361227 1.68611819857654 0.384615384615385 11.1 11 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0028977766872326 0.0171814009413833 1.68611819857654 0.384615384615385 11.1 11 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 4.97510388873689e-05 0.000769518786268761 1.67280673911409 0.381578947368421 11.1 11 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0287668937991001 0.0895739384597801 1.67005993001867 0.380952380952381 11.1 11 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.0287668937991001 0.0895739384597801 1.67005993001867 0.380952380952381 11.1 11 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0287668937991001 0.0895739384597801 1.67005993001867 0.380952380952381 11.1 11 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.00015222182344899 0.00196919686152648 1.65190710469238 0.376811594202899 11.1 11 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0601794319665298 0.158290816429523 1.64396524361213 0.375 11.1 11 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0601794319665298 0.158290816429523 1.64396524361213 0.375 11.1 11 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0601794319665298 0.158290816429523 1.64396524361213 0.375 11.1 11 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0601794319665298 0.158290816429523 1.64396524361213 0.375 11.1 11 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000684822020886737 0.00628710797239888 1.64396524361212 0.375 11.1 11 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.10292090860292e-06 6.89915070772181e-05 1.63400181789326 0.372727272727273 11.1 11 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00132752854776528 0.0101170759310189 1.63322037273884 0.372549019607843 11.1 11 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00759996615866107 0.033378863715354 1.6283084317682 0.371428571428571 11.1 11 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0187115670889944 0.066900904441304 1.62366937640704 0.37037037037037 11.1 11 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0187115670889944 0.066900904441304 1.62366937640704 0.37037037037037 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0187115670889944 0.066900904441304 1.62366937640704 0.37037037037037 11.1 11 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.11610606933874e-05 0.000230176657488264 1.62204570703063 0.37 11.1 11 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00258252164913166 0.0154408752382956 1.62013966037137 0.369565217391304 11.1 11 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 3.79825944526934e-08 1.28688647395673e-06 1.61656582288526 0.36875 11.1 11 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0477458145448224 0.131162729917533 1.61512374811016 0.368421052631579 11.1 11 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0477458145448224 0.131162729917533 1.61512374811016 0.368421052631579 11.1 11 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.09700306068602e-12 5.85350525514221e-11 1.61173063099228 0.367647058823529 11.1 11 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.0151198405745657 0.0564852751116039 1.60743268264297 0.366666666666667 11.1 11 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.000259930981938005 0.00307296264681224 1.605374510194 0.366197183098592 11.1 11 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.0050454209581256 0.0245899479208639 1.60386853035329 0.365853658536585 11.1 11 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.0050454209581256 0.0245899479208639 1.60386853035329 0.365853658536585 11.1 11 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.74787704327479e-07 1.2992748139577e-05 1.59699480808035 0.364285714285714 11.1 11 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00141861863708098 0.0105140329196158 1.59414811501782 0.363636363636364 11.1 11 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00141861863708098 0.0105140329196158 1.59414811501782 0.363636363636364 11.1 11 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00141861863708098 0.0105140329196158 1.59414811501782 0.363636363636364 11.1 11 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0380354852595251 0.108902405481498 1.59414811501782 0.363636363636364 11.1 11 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.18880159326029e-07 3.75925481602087e-06 1.59160966260537 0.363057324840764 11.1 11 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000408491792219425 0.00437055504006197 1.58837221605036 0.36231884057971 11.1 11 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.00116215690460987 0.00923882276681477 1.58727678693584 0.362068965517241 11.1 11 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.00116215690460987 0.00923882276681477 1.58727678693584 0.362068965517241 11.1 11 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000952238076037805 0.007924180012876 1.5810813271898 0.360655737704918 11.1 11 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0304037078721779 0.0938729796217453 1.57820663386764 0.36 11.1 11 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.000780393268103792 0.0070151250602689 1.57546669179495 0.359375 11.1 11 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00803531284612342 0.0345554642485167 1.57371031867144 0.358974358974359 11.1 11 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 6.66380721810463e-05 0.000967612007281928 1.57248849388986 0.358695652173913 11.1 11 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.9499578842334e-07 5.90380865800877e-06 1.571589415277 0.358490566037736 11.1 11 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00652269325240392 0.0297493349300345 1.5656811843925 0.357142857142857 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0243737314212259 0.0812267442913453 1.5656811843925 0.357142857142857 11.1 11 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 5.60897421240987e-07 1.50595666118099e-05 1.55744075710622 0.355263157894737 11.1 11 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.0195882061576276 0.0695112652426534 1.55558001546094 0.354838709677419 11.1 11 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.0195882061576276 0.0695112652426534 1.55558001546094 0.354838709677419 11.1 11 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.00431004460055522 0.0226317852855407 1.55263384118923 0.354166666666667 11.1 11 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000997888466515856 0.00825502182151192 1.55122874269042 0.353846153846154 11.1 11 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.47339904062684e-06 7.60407205355691e-05 1.54920032981995 0.353383458646617 11.1 11 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0157760711217401 0.0583099979382756 1.54726140575259 0.352941176470588 11.1 11 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0157760711217401 0.0583099979382756 1.54726140575259 0.352941176470588 11.1 11 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0788837211213537 0.192872053532107 1.54726140575259 0.352941176470588 11.1 11 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0788837211213537 0.192872053532107 1.54726140575259 0.352941176470588 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0127296350045137 0.0510261143983745 1.54029175978073 0.351351351351351 11.1 11 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0127296350045137 0.0510261143983745 1.54029175978073 0.351351351351351 11.1 11 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000107866687752998 0.00150484604580898 1.5390312918922 0.351063829787234 11.1 11 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 6.10754594420984e-07 1.60945145900196e-05 1.53436756070465 0.35 11.1 11 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.0620507679949253 0.160874021995765 1.53436756070465 0.35 11.1 11 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0620507679949253 0.160874021995765 1.53436756070465 0.35 11.1 11 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0620507679949253 0.160874021995765 1.53436756070465 0.35 11.1 11 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0620507679949253 0.160874021995765 1.53436756070465 0.35 11.1 11 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00155008258857122 0.0112535139993813 1.53088826918378 0.349206349206349 11.1 11 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.7675298318315e-54 2.51519495069622e-51 1.52545257810533 0.34796642995481 11.1 11 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.0491060689338002 0.133143678216046 1.52483732740835 0.347826086956522 11.1 11 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0491060689338002 0.133143678216046 1.52483732740835 0.347826086956522 11.1 11 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0491060689338002 0.133143678216046 1.52483732740835 0.347826086956522 11.1 11 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0491060689338002 0.133143678216046 1.52483732740835 0.347826086956522 11.1 11 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.24738015987068e-05 0.00025357456678514 1.51883403084375 0.346456692913386 11.1 11 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.039047484059714 0.111351843320587 1.51750637871888 0.346153846153846 11.1 11 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.41995324128528e-06 3.67380629517992e-05 1.51750637871888 0.346153846153846 11.1 11 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.0036165171826506 0.0197263633259533 1.51444070926693 0.345454545454545 11.1 11 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0036165171826506 0.0197263633259533 1.51444070926693 0.345454545454545 11.1 11 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.0036165171826506 0.0197263633259533 1.51444070926693 0.345454545454545 11.1 11 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.02109336123912e-09 4.40307834255536e-08 1.51287781895809 0.345098039215686 11.1 11 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00294291811658438 0.0172621466246555 1.51169217803414 0.344827586206897 11.1 11 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00294291811658438 0.0172621466246555 1.51169217803414 0.344827586206897 11.1 11 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0311693062739566 0.0950531281992411 1.51169217803414 0.344827586206897 11.1 11 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.81266370008629e-05 0.000470872993555623 1.51042184847276 0.34453781512605 11.1 11 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.48003896234747e-07 7.3522821737926e-06 1.50921399413572 0.344262295081967 11.1 11 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00195325318500654 0.0131107513314354 1.50696813997778 0.34375 11.1 11 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.00195325318500654 0.0131107513314354 1.50696813997778 0.34375 11.1 11 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0249602230663966 0.0826009242406567 1.50696813997778 0.34375 11.1 11 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00159293190518968 0.0112683451540708 1.50492340708772 0.343283582089552 11.1 11 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.13926935042855e-06 0.000151629556502385 1.5030539370168 0.342857142857143 11.1 11 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0200418650155204 0.0708794983557263 1.5030539370168 0.342857142857143 11.1 11 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000867047290639302 0.00743258008782968 1.49975776610229 0.342105263157895 11.1 11 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0161296892765361 0.0589175779387994 1.49975776610229 0.342105263157895 11.1 11 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.88467623712712e-05 0.000475265101688338 1.49694396166307 0.341463414634146 11.1 11 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.0105070762100659 0.0428411732003548 1.4945138578292 0.340909090909091 11.1 11 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00558594087818059 0.0266738049317147 1.488874182894 0.339622641509434 11.1 11 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00299931396499336 0.0172621466246555 1.48487183293998 0.338709677419355 11.1 11 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.00299931396499336 0.0172621466246555 1.48487183293998 0.338709677419355 11.1 11 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000482379127075529 0.00480165667930574 1.4777215672918 0.337078651685393 11.1 11 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 6.95814259537187e-08 2.25032657118504e-06 1.47458700639148 0.336363636363636 11.1 11 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00201104816673103 0.0132901687529297 1.46130243876633 0.333333333333333 11.1 11 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00201104816673103 0.0132901687529297 1.46130243876633 0.333333333333333 11.1 11 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.0251083527910422 0.08289834343771 1.46130243876633 0.333333333333333 11.1 11 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.100462028812074 0.227963870452861 1.46130243876633 0.333333333333333 11.1 11 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.100462028812074 0.227963870452861 1.46130243876633 0.333333333333333 11.1 11 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.100462028812074 0.227963870452861 1.46130243876633 0.333333333333333 11.1 11 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.100462028812074 0.227963870452861 1.46130243876633 0.333333333333333 11.1 11 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.000487940460312806 0.00480165667930574 1.46130243876633 0.333333333333333 11.1 11 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.000596487980500153 0.00554772808007659 1.46130243876633 0.333333333333333 11.1 11 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.0010926307016358 0.00888464850530139 1.46130243876633 0.333333333333333 11.1 11 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00246768773993561 0.0149306870149069 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00695028974745303 0.0313976581289704 1.46130243876633 0.333333333333333 11.1 11 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00695028974745303 0.0313976581289704 1.46130243876633 0.333333333333333 11.1 11 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00857605737827745 0.0362128476240024 1.46130243876633 0.333333333333333 11.1 11 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00857605737827745 0.0362128476240024 1.46130243876633 0.333333333333333 11.1 11 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00857605737827745 0.0362128476240024 1.46130243876633 0.333333333333333 11.1 11 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.0131106879799278 0.0513953415852264 1.46130243876633 0.333333333333333 11.1 11 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0162491461471642 0.0589860585903434 1.46130243876633 0.333333333333333 11.1 11 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0313238985152917 0.0950531281992411 1.46130243876633 0.333333333333333 11.1 11 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0492154425450738 0.133143678216046 1.46130243876633 0.333333333333333 11.1 11 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0492154425450738 0.133143678216046 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0492154425450738 0.133143678216046 1.46130243876633 0.333333333333333 11.1 11 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0620659438339249 0.160874021995765 1.46130243876633 0.333333333333333 11.1 11 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0620659438339249 0.160874021995765 1.46130243876633 0.333333333333333 11.1 11 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0786927050928381 0.192872053532107 1.46130243876633 0.333333333333333 11.1 11 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0786927050928381 0.192872053532107 1.46130243876633 0.333333333333333 11.1 11 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0786927050928381 0.192872053532107 1.46130243876633 0.333333333333333 11.1 11 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0786927050928381 0.192872053532107 1.46130243876633 0.333333333333333 11.1 11 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0201768774917425 0.0708930781993818 1.46130243876633 0.333333333333333 11.1 11 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0201768774917425 0.0708930781993818 1.46130243876633 0.333333333333333 11.1 11 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.05478556829861e-05 0.000493972711782833 1.45078947158096 0.330935251798561 11.1 11 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000897372074753315 0.00764646983457465 1.4446967292349 0.329545454545455 11.1 11 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00134454159302328 0.0101231888194293 1.44348167731796 0.329268292682927 11.1 11 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 0.00164709472385575 0.0112683451540708 1.44280493954144 0.329113924050633 11.1 11 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 0.00164709472385575 0.0112683451540708 1.44280493954144 0.329113924050633 11.1 11 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.00201890517700959 0.0132901687529297 1.44207477509836 0.328947368421053 11.1 11 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00247620670099651 0.0149306870149069 1.4412845971394 0.328767123287671 11.1 11 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0030391672214637 0.0172621466246555 1.4404266896411 0.328571428571429 11.1 11 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.9414134180223e-06 6.65558735862135e-05 1.43734666108164 0.327868852459016 11.1 11 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.000402653700862672 0.00436038000557404 1.43320046879006 0.326923076923077 11.1 11 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0130781826923627 0.0513953415852264 1.431479940016 0.326530612244898 11.1 11 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.94660578772414e-06 6.65558735862135e-05 1.43004463258951 0.32620320855615 11.1 11 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0161888777048985 0.0589175779387994 1.42953499444533 0.326086956521739 11.1 11 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0161888777048985 0.0589175779387994 1.42953499444533 0.326086956521739 11.1 11 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00134359875195222 0.0101231888194293 1.4273186611206 0.325581395348837 11.1 11 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0200733927177496 0.0708794983557263 1.4273186611206 0.325581395348837 11.1 11 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.00201515908951138 0.0132901687529297 1.42476987779718 0.325 11.1 11 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.024937992017264 0.0826009242406567 1.42476987779718 0.325 11.1 11 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.00026989507639172 0.0030830190110272 1.42284711143038 0.324561403508772 11.1 11 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.00302940663242548 0.0172621466246555 1.42180777825913 0.324324324324324 11.1 11 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.00302940663242548 0.0172621466246555 1.42180777825913 0.324324324324324 11.1 11 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.16571946887112e-21 4.3869094021018e-18 1.420138989787 0.323943661971831 11.1 11 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.000490452878268958 0.00480165667930574 1.41955094051587 0.323809523809524 11.1 11 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00456653939593938 0.0226317852855407 1.41832295527321 0.323529411764706 11.1 11 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0387598159643817 0.110753450034769 1.41832295527321 0.323529411764706 11.1 11 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.000148369668579874 0.00193697282925836 1.4152771651044 0.322834645669291 11.1 11 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 5.26496358160618e-06 0.000113515805706448 1.41416365041903 0.32258064516129 11.1 11 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00690584738868433 0.0313962326967981 1.41416365041903 0.32258064516129 11.1 11 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0485301500598542 0.133060507774899 1.41416365041903 0.32258064516129 11.1 11 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00850436756815827 0.0362128476240024 1.41176676287595 0.322033898305085 11.1 11 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00163503808193985 0.0112683451540708 1.41091269949853 0.32183908045977 11.1 11 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00163503808193985 0.0112683451540708 1.41091269949853 0.32183908045977 11.1 11 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0609825688668966 0.159812514728534 1.40911306595325 0.321428571428571 11.1 11 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000487361588760247 0.00480165667930574 1.40767666119693 0.321100917431193 11.1 11 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 0.00245126341832529 0.014906614719132 1.40718012621943 0.320987654320988 11.1 11 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 0.00245126341832529 0.014906614719132 1.40718012621943 0.320987654320988 11.1 11 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00245126341832529 0.014906614719132 1.40718012621943 0.320987654320988 11.1 11 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.00300385158060397 0.0172621466246555 1.40509849881378 0.320512820512821 11.1 11 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 5.11569277044842e-15 1.45592616246962e-12 1.40500006809583 0.320490367775832 11.1 11 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0159918292000766 0.0586504457518272 1.40285034121568 0.32 11.1 11 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0159918292000766 0.0586504457518272 1.40285034121568 0.32 11.1 11 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000266470198273595 0.00308282188734411 1.4014129945546 0.319672131147541 11.1 11 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00451925885515973 0.0226317852855407 1.40041483715107 0.319444444444444 11.1 11 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00451925885515973 0.0226317852855407 1.40041483715107 0.319444444444444 11.1 11 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0245376737546685 0.0815820321329283 1.39487960064059 0.318181818181818 11.1 11 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0976660743483841 0.224159393222178 1.39487960064059 0.318181818181818 11.1 11 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.11064400484076e-12 5.85350525514221e-11 1.39045141143221 0.317171717171717 11.1 11 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.000321060576494684 0.00359739527836169 1.39001939297285 0.317073170731707 11.1 11 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00296509855150122 0.0172621466246555 1.39001939297285 0.317073170731707 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0304773834049518 0.0938729796217453 1.39001939297285 0.317073170731707 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0304773834049518 0.0938729796217453 1.39001939297285 0.317073170731707 11.1 11 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0304773834049518 0.0938729796217453 1.39001939297285 0.317073170731707 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0304773834049518 0.0938729796217453 1.39001939297285 0.317073170731707 11.1 11 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.0103227769207424 0.0426374670863918 1.38823731682802 0.316666666666667 11.1 11 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.36181754500443e-05 0.000794777746514719 1.38731244186677 0.316455696202532 11.1 11 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00363197975502444 0.0197263633259533 1.38731244186677 0.316455696202532 11.1 11 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.00363197975502444 0.0197263633259533 1.38731244186677 0.316455696202532 11.1 11 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.124792589243113 0.272780114428494 1.38439178409442 0.315789473684211 11.1 11 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.124792589243113 0.272780114428494 1.38439178409442 0.315789473684211 11.1 11 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.124792589243113 0.272780114428494 1.38439178409442 0.315789473684211 11.1 11 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.0156917858760054 0.0583099979382756 1.38011896994598 0.314814814814815 11.1 11 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.000142307230843195 0.00187502953231358 1.3795512533808 0.314685314685315 11.1 11 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.00822730156492727 0.0352634039966612 1.37406050212357 0.313432835820896 11.1 11 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00356723688657818 0.0197263633259533 1.37327217137077 0.313253012048193 11.1 11 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0592437532386985 0.15699042990441 1.36997103634344 0.3125 11.1 11 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0743985370337196 0.188044614918265 1.36052296023072 0.310344827586207 11.1 11 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.000451857535999705 0.00478416215880937 1.35935110582915 0.310077519379845 11.1 11 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.00803784867621857 0.0345554642485167 1.358393816318 0.309859154929577 11.1 11 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.01525789375335e-05 0.000212457644531033 1.35692369314017 0.30952380952381 11.1 11 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00426913963034882 0.0225835899404698 1.35692369314017 0.30952380952381 11.1 11 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00426913963034882 0.0225835899404698 1.35692369314017 0.30952380952381 11.1 11 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 0.000537096648535295 0.00509754886214448 1.34889455886123 0.307692307692308 11.1 11 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0938184131454805 0.219578292608584 1.34889455886123 0.307692307692308 11.1 11 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0938184131454805 0.219578292608584 1.34889455886123 0.307692307692308 11.1 11 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0938184131454805 0.219578292608584 1.34889455886123 0.307692307692308 11.1 11 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 8.0405090200095e-09 3.09233630688474e-07 1.34799289137536 0.307486631016043 11.1 11 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.82713650339585e-06 6.5951069579218e-05 1.33952723553581 0.305555555555556 11.1 11 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.82713650339585e-06 6.5951069579218e-05 1.33952723553581 0.305555555555556 11.1 11 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.82713650339585e-06 6.5951069579218e-05 1.33952723553581 0.305555555555556 11.1 11 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00759459184709866 0.033378863715354 1.3318199441921 0.30379746835443 11.1 11 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.000270820362880112 0.0030830190110272 1.32931383139389 0.303225806451613 11.1 11 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.071382820509745 0.181065514412419 1.32845676251485 0.303030303030303 11.1 11 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.00602249670556464 0.0283651506814396 1.32536732818342 0.302325581395349 11.1 11 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0441278306649272 0.123367196534757 1.32536732818342 0.302325581395349 11.1 11 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0441278306649272 0.123367196534757 1.32536732818342 0.302325581395349 11.1 11 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0277706023038263 0.0870430992915085 1.323443718128 0.30188679245283 11.1 11 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0277706023038263 0.0870430992915085 1.323443718128 0.30188679245283 11.1 11 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 0.0113662877608377 0.0462120785247773 1.32117754737778 0.301369863013699 11.1 11 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.151681941206622 0.318353100792069 1.3151721948897 0.3 11.1 11 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.151681941206622 0.318353100792069 1.3151721948897 0.3 11.1 11 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.00379722868167232 0.0203904015623386 1.3151721948897 0.3 11.1 11 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.0139150489692811 0.053516526171046 1.3151721948897 0.3 11.1 11 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.0217266483113375 0.0745415976066133 1.3151721948897 0.3 11.1 11 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00301883050444794 0.0172621466246555 1.3110750852483 0.299065420560748 11.1 11 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.04231835353849 0.119719715875291 1.3058447325146 0.297872340425532 11.1 11 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.04231835353849 0.119719715875291 1.3058447325146 0.297872340425532 11.1 11 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.000828702113517645 0.00722542437893509 1.3058447325146 0.297872340425532 11.1 11 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000279981557604057 0.00316201394024264 1.29987949494912 0.296511627906977 11.1 11 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.11259861129302 0.251140789764839 1.29893550112563 0.296296296296296 11.1 11 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.11259861129302 0.251140789764839 1.29893550112563 0.296296296296296 11.1 11 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.22264012075135e-05 0.000660309548552656 1.29747929540688 0.295964125560538 11.1 11 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.00541981157979879 0.0259676494210562 1.2972786956395 0.295918367346939 11.1 11 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.000492650650160673 0.00480165667930574 1.29096657167087 0.294478527607362 11.1 11 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0849757390703132 0.204949960503484 1.28938450479382 0.294117647058824 11.1 11 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0849757390703132 0.204949960503484 1.28938450479382 0.294117647058824 11.1 11 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.0157169123584993 0.0583099979382756 1.28594614611437 0.293333333333333 11.1 11 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0648408298115023 0.167553946072172 1.28309482428263 0.292682926829268 11.1 11 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.21613445217964e-09 5.08988036897536e-08 1.28069202498622 0.292134831460674 11.1 11 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.049872274373291 0.134470181922374 1.27863963392054 0.291666666666667 11.1 11 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.142317896139816 0.30091882051554 1.27863963392054 0.291666666666667 11.1 11 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.00100359717155416 0.00825502182151192 1.27274728537713 0.290322580645161 11.1 11 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.106240918105082 0.238455562245318 1.27274728537713 0.290322580645161 11.1 11 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.106240918105082 0.238455562245318 1.27274728537713 0.290322580645161 11.1 11 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.00736587887365294 0.0330455156581383 1.27133312172671 0.29 11.1 11 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0143945549974234 0.0540460468636767 1.2676358504961 0.289156626506024 11.1 11 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.00705160766188766 0.0317545496926143 1.2645886489324 0.288461538461538 11.1 11 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 0.000736987394667267 0.00672264783725334 1.26359681469795 0.288235294117647 11.1 11 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0367424110495933 0.106776033520023 1.2631597352048 0.288135593220339 11.1 11 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0367424110495933 0.106776033520023 1.2631597352048 0.288135593220339 11.1 11 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0583093017266164 0.154802493203312 1.252544947514 0.285714285714286 11.1 11 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 0.000263562305521321 0.00307417344882656 1.252544947514 0.285714285714286 11.1 11 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0760349382451397 0.190282824211907 1.252544947514 0.285714285714286 11.1 11 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.100030483972061 0.227963870452861 1.252544947514 0.285714285714286 11.1 11 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.180877635652135 0.350188946303386 1.252544947514 0.285714285714286 11.1 11 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.133245028263469 0.282996530177488 1.252544947514 0.285714285714286 11.1 11 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.133245028263469 0.282996530177488 1.252544947514 0.285714285714286 11.1 11 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.133245028263469 0.282996530177488 1.252544947514 0.285714285714286 11.1 11 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.31261350419817e-07 1.2273698032948e-05 1.24519433162483 0.284037558685446 11.1 11 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 0.00117229071912247 0.00926760940728484 1.24513343894883 0.284023668639053 11.1 11 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0331704346630238 0.0995812838090357 1.24319759715942 0.283582089552239 11.1 11 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0331704346630238 0.0995812838090357 1.24319759715942 0.283582089552239 11.1 11 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.0551746307196358 0.146754204699144 1.240728485745 0.283018867924528 11.1 11 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0717589021961791 0.181695583318795 1.23893032851928 0.282608695652174 11.1 11 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0404260074133453 0.115052417098381 1.23297393270909 0.28125 11.1 11 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.124631113052797 0.272780114428494 1.23297393270909 0.28125 11.1 11 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.000778332299105157 0.0070151250602689 1.23297393270909 0.28125 11.1 11 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00242522594368132 0.014906614719132 1.2286109676252 0.280254777070064 11.1 11 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 0.000128604481097823 0.00172645449624719 1.22615032218325 0.279693486590038 11.1 11 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0883860766632865 0.212701824152625 1.22341599524623 0.27906976744186 11.1 11 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 6.30196951085085e-12 3.20275093355027e-10 1.21995610838185 0.278280542986425 11.1 11 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0361947370831496 0.1061961048852 1.21775203230528 0.277777777777778 11.1 11 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.116534398043278 0.25951243883503 1.21775203230528 0.277777777777778 11.1 11 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.231489980205786 0.408207041496627 1.21775203230528 0.277777777777778 11.1 11 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.231489980205786 0.408207041496627 1.21775203230528 0.277777777777778 11.1 11 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.38632196933781e-07 4.2885568747124e-06 1.21682598513242 0.277566539923954 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.0117122960870041 0.0474831832815008 1.21340291790419 0.276785714285714 11.1 11 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.79828710936569e-05 0.00123960025313142 1.21193342191201 0.276450511945392 11.1 11 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.155662739208136 0.322962858070875 1.20935374242731 0.275862068965517 11.1 11 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.108963127231752 0.244180362284698 1.20557451198222 0.275 11.1 11 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.041423341139843 0.117655517848297 1.20107049761616 0.273972602739726 11.1 11 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.0159913044488425 0.0586504457518272 1.19561108626336 0.272727272727273 11.1 11 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.144599222756442 0.304836583677654 1.19561108626336 0.272727272727273 11.1 11 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.144599222756442 0.304836583677654 1.19561108626336 0.272727272727273 11.1 11 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.212081971141042 0.388407522437198 1.19561108626336 0.272727272727273 11.1 11 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.212081971141042 0.388407522437198 1.19561108626336 0.272727272727273 11.1 11 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0368520480635182 0.106776033520023 1.19069087603183 0.271604938271605 11.1 11 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0501202244779117 0.134822456393324 1.1899177001383 0.271428571428571 11.1 11 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.0191656581860406 0.0683527107737739 1.18816179600627 0.271028037383178 11.1 11 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0953259541794689 0.222375135733417 1.18730823149765 0.270833333333333 11.1 11 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.26854939250638e-06 5.56576859575272e-05 1.1850806363166 0.270325203252033 11.1 11 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.134454547422541 0.285139822626342 1.18483981521595 0.27027027027027 11.1 11 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0892044252274748 0.213268062505894 1.18028273900358 0.269230769230769 11.1 11 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0892044252274748 0.213268062505894 1.18028273900358 0.269230769230769 11.1 11 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.19496413237098 0.362425332087666 1.18028273900358 0.269230769230769 11.1 11 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.19496413237098 0.362425332087666 1.18028273900358 0.269230769230769 11.1 11 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.19496413237098 0.362425332087666 1.18028273900358 0.269230769230769 11.1 11 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.19496413237098 0.362425332087666 1.18028273900358 0.269230769230769 11.1 11 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0606140112745146 0.159139738087886 1.17776614467734 0.26865671641791 11.1 11 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.021671433558727 0.0745415976066133 1.1771602978951 0.268518518518519 11.1 11 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.12514130295251 0.273122813038991 1.17617025559241 0.268292682926829 11.1 11 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.037055157025703 0.106956366019423 1.16904195101307 0.266666666666667 11.1 11 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.179726942921939 0.348435204057111 1.16904195101307 0.266666666666667 11.1 11 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 0.000951692060632881 0.007924180012876 1.16342155701781 0.265384615384615 11.1 11 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.166063676883448 0.332829031274854 1.16044605431444 0.264705882352941 11.1 11 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 0.00228287163974956 0.0145666392542034 1.15986785498494 0.26457399103139 11.1 11 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0947024559795959 0.221283406993374 1.15365982007868 0.263157894736842 11.1 11 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.153738601109369 0.321720631439164 1.15365982007868 0.263157894736842 11.1 11 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.0369176447588554 0.106776033520023 1.15132919417954 0.262626262626263 11.1 11 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.0369176447588554 0.106776033520023 1.15132919417954 0.262626262626263 11.1 11 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0884887420227364 0.212701824152625 1.14987732886531 0.262295081967213 11.1 11 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.00968515223451576 0.0406547835684836 1.14943911341986 0.26219512195122 11.1 11 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0326739964258205 0.0985065612583528 1.14719069959226 0.261682242990654 11.1 11 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0498947688369738 0.134470181922374 1.14579395766906 0.261363636363636 11.1 11 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.0773976675335645 0.191209862674067 1.14362799555626 0.260869565217391 11.1 11 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.132397130459008 0.282460444742381 1.14362799555626 0.260869565217391 11.1 11 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.244965816231787 0.426666287023052 1.14362799555626 0.260869565217391 11.1 11 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.244965816231787 0.426666287023052 1.14362799555626 0.260869565217391 11.1 11 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.223792064748267 0.402447449017216 1.13656856348493 0.259259259259259 11.1 11 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.223792064748267 0.402447449017216 1.13656856348493 0.259259259259259 11.1 11 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.223792064748267 0.402447449017216 1.13656856348493 0.259259259259259 11.1 11 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.223792064748267 0.402447449017216 1.13656856348493 0.259259259259259 11.1 11 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0524007403059189 0.140691044255326 1.13133092033523 0.258064516129032 11.1 11 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.205287299379977 0.379381593529489 1.13133092033523 0.258064516129032 11.1 11 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.205287299379977 0.379381593529489 1.13133092033523 0.258064516129032 11.1 11 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.0253116993350044 0.0833762688743316 1.12918824813762 0.257575757575758 11.1 11 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.188921320583543 0.357018644343136 1.1272904527626 0.257142857142857 11.1 11 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.17766205394838e-08 8.1547713230751e-07 1.11901538103728 0.255255255255255 11.1 11 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.00122221091013944 0.00950385860725915 1.11614818175711 0.254601226993865 11.1 11 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.119763568248339 0.266286808777166 1.11455270753364 0.254237288135593 11.1 11 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.111532082411719 0.24954426615075 1.11337328667911 0.253968253968254 11.1 11 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.0033952722348 0.0190215448429937 1.10784661422718 0.252707581227437 11.1 11 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.0648785834755915 0.167553946072172 1.10751342727554 0.252631578947368 11.1 11 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.0365919947044107 0.106776033520023 1.1043430644112 0.251908396946565 11.1 11 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.0365919947044107 0.106776033520023 1.1043430644112 0.251908396946565 11.1 11 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.213050294763632 0.389679395178211 1.09597682907475 0.25 11.1 11 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.167328611113122 0.333400684888961 1.09597682907475 0.25 11.1 11 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.196100514947882 0.363821424733815 1.09597682907475 0.25 11.1 11 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.23217269482237 0.408207041496627 1.09597682907475 0.25 11.1 11 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.279181789595777 0.469170994633351 1.09597682907475 0.25 11.1 11 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.308900941282971 0.501821450295924 1.09597682907475 0.25 11.1 11 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.308900941282971 0.501821450295924 1.09597682907475 0.25 11.1 11 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.253974410243199 0.436480176058058 1.09597682907475 0.25 11.1 11 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00778685352329612 0.0340944386573858 1.09157531570497 0.248995983935743 11.1 11 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.0225767427201987 0.0761296324427553 1.08978486958845 0.248587570621469 11.1 11 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.103909259748766 0.233960247820403 1.08244625093802 0.246913580246914 11.1 11 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.201780475155621 0.373871896024021 1.07162178842864 0.244444444444444 11.1 11 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.0230073886694828 0.0773983784318536 1.0646632053869 0.242857142857143 11.1 11 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.141555480225346 0.299752155298613 1.0646632053869 0.242857142857143 11.1 11 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.15222270563936 0.319017540684549 1.06276541001188 0.242424242424242 11.1 11 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.260196205883467 0.44555860526134 1.06276541001188 0.242424242424242 11.1 11 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.260196205883467 0.44555860526134 1.06276541001188 0.242424242424242 11.1 11 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.260196205883467 0.44555860526134 1.06276541001188 0.242424242424242 11.1 11 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 0.00167453260153005 0.0114012435022835 1.06157396896926 0.242152466367713 11.1 11 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.314376272864076 0.507783696124381 1.05213775591176 0.24 11.1 11 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.314376272864076 0.507783696124381 1.05213775591176 0.24 11.1 11 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.314376272864076 0.507783696124381 1.05213775591176 0.24 11.1 11 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.223586669203128 0.402447449017216 1.04832566259324 0.239130434782609 11.1 11 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.348908224292606 0.528465709519633 1.04378745626167 0.238095238095238 11.1 11 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.348908224292606 0.528465709519633 1.04378745626167 0.238095238095238 11.1 11 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.158493134855475 0.322962858070875 1.03829383807082 0.236842105263158 11.1 11 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.289160060960395 0.482951604162726 1.03150760383506 0.235294117647059 11.1 11 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.289160060960395 0.482951604162726 1.03150760383506 0.235294117647059 11.1 11 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.289160060960395 0.482951604162726 1.03150760383506 0.235294117647059 11.1 11 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.289160060960395 0.482951604162726 1.03150760383506 0.235294117647059 11.1 11 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.317372751912838 0.51130460627645 1.02291170713643 0.233333333333333 11.1 11 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.317372751912838 0.51130460627645 1.02291170713643 0.233333333333333 11.1 11 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.350199915012004 0.529017493696478 1.01167091914592 0.230769230769231 11.1 11 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.350199915012004 0.529017493696478 1.01167091914592 0.230769230769231 11.1 11 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.269747927754485 0.460253358746561 1.00464542665185 0.229166666666667 11.1 11 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.269747927754485 0.460253358746561 1.00464542665185 0.229166666666667 11.1 11 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.269747927754485 0.460253358746561 1.00464542665185 0.229166666666667 11.1 11 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.38915123992542 0.575492029562097 0.996342571886136 0.227272727272727 11.1 11 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 0.0102001382221984 0.0426374670863918 0.974959169876761 0.222395023328149 11.1 11 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.294140301923517 0.490693610360099 0.974201625844222 0.222222222222222 11.1 11 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.349091895255415 0.528465709519633 0.974201625844222 0.222222222222222 11.1 11 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.386316443658788 0.575492029562097 0.974201625844222 0.222222222222222 11.1 11 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.386316443658788 0.575492029562097 0.974201625844222 0.222222222222222 11.1 11 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.184243489879753 0.351470989909863 0.966530746900567 0.220472440944882 11.1 11 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.317634063210388 0.51130460627645 0.956488869010691 0.218181818181818 11.1 11 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.345776689088681 0.525684004885891 0.953023329630217 0.217391304347826 11.1 11 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.270978970306828 0.461800089516905 0.94652544329183 0.215909090909091 11.1 11 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.146711729449789 0.308832531075517 0.940752642982618 0.214592274678112 11.1 11 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.376162854155346 0.566433588849796 0.9394087106355 0.214285714285714 11.1 11 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.422409725499402 0.616501578857076 0.9394087106355 0.214285714285714 11.1 11 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.422409725499402 0.616501578857076 0.9394087106355 0.214285714285714 11.1 11 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.249570036715826 0.433624129727253 0.934275329703066 0.213114754098361 11.1 11 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.339267668676279 0.519116013469187 0.934275329703066 0.213114754098361 11.1 11 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.416156487486931 0.608623516643271 0.929919733760394 0.212121212121212 11.1 11 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.416156487486931 0.608623516643271 0.929919733760394 0.212121212121212 11.1 11 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.416156487486931 0.608623516643271 0.929919733760394 0.212121212121212 11.1 11 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.369201991908787 0.556540714498097 0.927365009217096 0.211538461538462 11.1 11 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.399752913814583 0.587653302022884 0.913314024228958 0.208333333333333 11.1 11 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.468681945694144 0.647509134682298 0.913314024228958 0.208333333333333 11.1 11 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.468681945694144 0.647509134682298 0.913314024228958 0.208333333333333 11.1 11 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.346553138369561 0.526302151440646 0.907015306820483 0.206896551724138 11.1 11 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.390234269586196 0.575492029562097 0.907015306820483 0.206896551724138 11.1 11 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.390234269586196 0.575492029562097 0.907015306820483 0.206896551724138 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.390234269586196 0.575492029562097 0.907015306820483 0.206896551724138 11.1 11 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.458189115677952 0.63756245959007 0.907015306820483 0.206896551724138 11.1 11 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.426897065036293 0.622412421666644 0.89467496251 0.204081632653061 11.1 11 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.352268722982092 0.531578359282627 0.89301815702387 0.203703703703704 11.1 11 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.301792022204774 0.499360520462085 0.8767814632598 0.2 11.1 11 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.336654548992975 0.516175267245809 0.8767814632598 0.2 11.1 11 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.405343007120819 0.594642370240129 0.8767814632598 0.2 11.1 11 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.446401538626109 0.63756245959007 0.8767814632598 0.2 11.1 11 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.453973425993991 0.63756245959007 0.8767814632598 0.2 11.1 11 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.446401538626109 0.63756245959007 0.8767814632598 0.2 11.1 11 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.462241215422425 0.639853355589601 0.8767814632598 0.2 11.1 11 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.49339320661923 0.679012120908282 0.8767814632598 0.2 11.1 11 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.507258363901661 0.68968129983539 0.8767814632598 0.2 11.1 11 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.507258363901661 0.68968129983539 0.8767814632598 0.2 11.1 11 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.507258363901661 0.68968129983539 0.8767814632598 0.2 11.1 11 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.405162178676087 0.594642370240129 0.86888253115836 0.198198198198198 11.1 11 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.449399890433916 0.63756245959007 0.864432428566 0.197183098591549 11.1 11 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.439128102073377 0.63756245959007 0.858703494945165 0.195876288659794 11.1 11 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.490570424530632 0.67578094298847 0.857720996667196 0.195652173913043 11.1 11 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.501385697185597 0.685371611042367 0.855396549521756 0.195121951219512 11.1 11 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.178058391626321 0.345671338723403 0.848981075400343 0.193658536585366 11.1 11 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.447435145207582 0.63756245959007 0.848498190251419 0.193548387096774 11.1 11 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.447435145207582 0.63756245959007 0.848498190251419 0.193548387096774 11.1 11 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.447435145207582 0.63756245959007 0.848498190251419 0.193548387096774 11.1 11 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.527792134071464 0.709205105555895 0.848498190251419 0.193548387096774 11.1 11 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.527792134071464 0.709205105555895 0.848498190251419 0.193548387096774 11.1 11 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.507446465866235 0.68968129983539 0.843059099288269 0.192307692307692 11.1 11 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.544653232684913 0.729794303305679 0.843059099288269 0.192307692307692 11.1 11 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.544653232684913 0.729794303305679 0.843059099288269 0.192307692307692 11.1 11 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.530849895545655 0.712640944680629 0.835029965009333 0.19047619047619 11.1 11 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.504225322564807 0.687931576231755 0.830635070456653 0.189473684210526 11.1 11 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.504225322564807 0.687931576231755 0.830635070456653 0.189473684210526 11.1 11 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.559579245667987 0.733650487873738 0.809336735316739 0.184615384615385 11.1 11 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.572671338310615 0.748311583485772 0.805207466259 0.183673469387755 11.1 11 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.568707581454841 0.743815154788823 0.801934265176646 0.182926829268293 11.1 11 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.57553020445975 0.748483785694245 0.799580579702333 0.182389937106918 11.1 11 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.57553020445975 0.748483785694245 0.799580579702333 0.182389937106918 11.1 11 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.584390765738533 0.753932964320881 0.797074057508909 0.181818181818182 11.1 11 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.593417989795496 0.762124367760822 0.797074057508909 0.181818181818182 11.1 11 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.595071750205359 0.763559152878473 0.790540663594902 0.180327868852459 11.1 11 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.599159846518482 0.768112127563783 0.78910331693382 0.18 11.1 11 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.615036505914287 0.786340474318087 0.78284059219625 0.178571428571429 11.1 11 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.624347240403794 0.795191832631422 0.773630702876294 0.176470588235294 11.1 11 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.632921750581984 0.795191832631422 0.767183780352325 0.175 11.1 11 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.649573340896672 0.803776403561708 0.764634997028895 0.174418604651163 11.1 11 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.710438849104496 0.854568455009043 0.756613445452619 0.17258883248731 11.1 11 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.679909032449843 0.833724698799764 0.752792165425081 0.171717171717172 11.1 11 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.70153664007857 0.853760078035766 0.7515269685084 0.171428571428571 11.1 11 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.660002702751829 0.815972064305693 0.748471980831537 0.170731707317073 11.1 11 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.666006829625453 0.822680311247412 0.74619699000834 0.170212765957447 11.1 11 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.724098516937246 0.869325318397789 0.741396090256449 0.169117647058824 11.1 11 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.7372673042847 0.882364486120377 0.735984439962606 0.167883211678832 11.1 11 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.751817868457501 0.895371216651734 0.735189425714739 0.167701863354037 11.1 11 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.678577013332383 0.833724698799764 0.730651219383167 0.166666666666667 11.1 11 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.678577013332383 0.833724698799764 0.730651219383167 0.166666666666667 11.1 11 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.763269369804609 0.895371216651734 0.730651219383167 0.166666666666667 11.1 11 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.774375263478742 0.906943209819136 0.726168696564865 0.165644171779141 11.1 11 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.71037084906254 0.854568455009043 0.713659330560302 0.162790697674419 11.1 11 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.708444151567061 0.853760078035766 0.710903889129567 0.162162162162162 11.1 11 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.811557316164302 0.93889923650553 0.707081825209516 0.161290322580645 11.1 11 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.805998331028549 0.934143894878579 0.703985116485971 0.160583941605839 11.1 11 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.75845546941005 0.895371216651734 0.698883775062159 0.159420289855072 11.1 11 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.755480803659538 0.895371216651734 0.681941138090956 0.155555555555556 11.1 11 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.854892851872067 0.977903961586778 0.679196908159 0.154929577464789 11.1 11 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.832158517386156 0.961170105714692 0.674447279430615 0.153846153846154 11.1 11 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.960624478249205 1 0.626272473757 0.142857142857143 11.1 11 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.873125357955996 0.991586100855054 0.590141369501789 0.134615384615385 11.1 11 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.998989506585055 1 0.564936509832345 0.128865979381443 11.1 11 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.903281580435435 1 0.547988414537375 0.125 11.1 11 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999586401402695 1 0.5010179790056 0.114285714285714 11.1 11 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.945553403110056 1 0.496291394298 0.113207547169811 11.1 11 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999999964 1 0.474831271034904 0.10831234256927 11.1 11 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.958297636135468 1 0.456657012114479 0.104166666666667 11.1 11 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.986575822752651 1 0.443939981397367 0.10126582278481 11.1 11 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99964643084728 1 0.423445593051608 0.0965909090909091 11.1 11 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.404302483058316 0.0922242314647378 11.1 11 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0707081825209516 0.0161290322580645 11.1 11 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.75999023771518e-08 1.1230789723178e-07 0.936632985100188 1 11.5 11 5 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 6.61023824829118e-08 3.5650533339356e-07 0.936632985100188 1 11.5 11 5 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 6.61023824829118e-08 3.5650533339356e-07 0.936632985100188 1 11.5 11 5 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 6.61023824829118e-08 3.5650533339356e-07 0.936632985100188 1 11.5 11 5 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 1.28100998466285e-07 6.51027574348296e-07 0.936632985100188 1 11.5 11 5 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 1.28100998466285e-07 6.51027574348296e-07 0.936632985100188 1 11.5 11 5 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 4.81046738419358e-07 2.23702453846649e-06 0.936632985100188 1 11.5 11 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.80623386905028e-06 7.7886993807835e-06 0.936632985100188 1 11.5 11 5 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 1.80623386905028e-06 7.7886993807835e-06 0.936632985100188 1 11.5 11 5 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 1.80623386905028e-06 7.7886993807835e-06 0.936632985100188 1 11.5 11 5 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 1.31390499053504e-05 5.09451444558954e-05 0.936632985100188 1 11.5 11 5 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.31390499053504e-05 5.09451444558954e-05 0.936632985100188 1 11.5 11 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 4.93208525022096e-05 0.000171179446611328 0.936632985100188 1 11.5 11 5 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 4.93208525022096e-05 0.000171179446611328 0.936632985100188 1 11.5 11 5 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 4.93208525022096e-05 0.000171179446611328 0.936632985100188 1 11.5 11 5 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 4.93208525022096e-05 0.000171179446611328 0.936632985100188 1 11.5 11 5 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 4.93208525022096e-05 0.000171179446611328 0.936632985100188 1 11.5 11 5 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 4.93208525022096e-05 0.000171179446611328 0.936632985100188 1 11.5 11 5 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 4.93208525022096e-05 0.000171179446611328 0.936632985100188 1 11.5 11 5 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.000358624910067191 0.00104789167767066 0.936632985100188 1 11.5 11 5 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000694735894842263 0.00192336416023451 0.936632985100188 1 11.5 11 5 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00134582013695553 0.00335713973552751 0.936632985100188 1 11.5 11 5 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0189468127333443 0.0345215294744545 0.936632985100188 1 11.5 11 5 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605631 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 G2 PHASE%REACTOME%REACT_227891.1 G2 PHASE 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%REACT_196555.2 ABACAVIR TRANSMEMBRANE TRANSPORT 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.036698089373133 0.0618004510981873 0.936632985100188 1 11.5 11 5 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 3.41090555588983e-08 1.95714459920614e-07 0.936632985100188 1 11.5 11 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.48242365897194e-07 1.19745385312443e-06 0.936632985100188 1 11.5 11 5 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 9.32151781700474e-07 4.18439112100875e-06 0.936632985100188 1 11.5 11 5 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 9.32151781700474e-07 4.18439112100875e-06 0.936632985100188 1 11.5 11 5 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 9.32151781700474e-07 4.18439112100875e-06 0.936632985100188 1 11.5 11 5 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 6.78129511144105e-06 2.77292613321282e-05 0.936632985100188 1 11.5 11 5 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 2.54567684241256e-05 9.60874839987551e-05 0.936632985100188 1 11.5 11 5 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 2.54567684241256e-05 9.60874839987551e-05 0.936632985100188 1 11.5 11 5 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 9.55533399045837e-05 0.000318436540244081 0.936632985100188 1 11.5 11 5 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 9.55533399045837e-05 0.000318436540244081 0.936632985100188 1 11.5 11 5 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 9.55533399045837e-05 0.000318436540244081 0.936632985100188 1 11.5 11 5 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000185118219235851 0.000594634821608615 0.936632985100188 1 11.5 11 5 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.000185118219235851 0.000594634821608615 0.936632985100188 1 11.5 11 5 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000185118219235851 0.000594634821608615 0.936632985100188 1 11.5 11 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.00260700765049389 0.00603214940919155 0.936632985100188 1 11.5 11 5 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00504993269028218 0.0108223708106499 0.936632985100188 1 11.5 11 5 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.00978175711343805 0.0192523379978179 0.936632985100188 1 11.5 11 5 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 7.44201409324162e-13 7.41249342937713e-12 0.917119797910601 0.979166666666667 11.5 11 5 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 4.44675336940709e-10 3.53504471769066e-09 0.911984748650184 0.973684210526316 11.5 11 5 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.58541352422303e-09 1.15104257396397e-08 0.910615402180739 0.972222222222222 11.5 11 5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 7.04583750434122e-08 3.74112939129759e-07 0.905411885596849 0.966666666666667 11.5 11 5 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.32158294765134e-07 6.69257129718096e-07 0.904335295958803 0.96551724137931 11.5 11 5 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 2.47607370712169e-07 1.19745385312443e-06 0.903181807060896 0.964285714285714 11.5 11 5 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.63347038284307e-07 2.16177978845433e-06 0.901942874540922 0.962962962962963 11.5 11 5 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 8.65935555583252e-07 3.93682522554303e-06 0.900608639519412 0.961538461538462 11.5 11 5 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.61606778206722e-06 7.09772979593101e-06 0.899167665696181 0.96 11.5 11 5 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.61606778206722e-06 7.09772979593101e-06 0.899167665696181 0.96 11.5 11 5 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 3.0114938168081e-06 1.27079411921006e-05 0.897606610721014 0.958333333333333 11.5 11 5 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 5.60274293390697e-06 2.31092846230424e-05 0.895909811834963 0.956521739130435 11.5 11 5 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 5.60274293390697e-06 2.31092846230424e-05 0.895909811834963 0.956521739130435 11.5 11 5 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.30463956516448e-15 4.04876802620872e-14 0.894694194722568 0.955223880597015 11.5 11 5 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 1.04053576906039e-05 4.12446350800262e-05 0.894058758504725 0.954545454545455 11.5 11 5 KINESINS%REACTOME%REACT_199117.2 KINESINS 1.04053576906039e-05 4.12446350800262e-05 0.894058758504725 0.954545454545455 11.5 11 5 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 1.04053576906039e-05 4.12446350800262e-05 0.894058758504725 0.954545454545455 11.5 11 5 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 1.04053576906039e-05 4.12446350800262e-05 0.894058758504725 0.954545454545455 11.5 11 5 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 6.04728852097296e-19 2.26455041193277e-17 0.892556138742532 0.952941176470588 11.5 11 5 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 6.04728852097296e-19 2.26455041193277e-17 0.892556138742532 0.952941176470588 11.5 11 5 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 6.04728852097296e-19 2.26455041193277e-17 0.892556138742532 0.952941176470588 11.5 11 5 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 1.92878756160465e-05 7.35835040258287e-05 0.892031414381132 0.952380952380952 11.5 11 5 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 1.92878756160465e-05 7.35835040258287e-05 0.892031414381132 0.952380952380952 11.5 11 5 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.26826982143488e-09 9.39972893698873e-09 0.890943571192862 0.951219512195122 11.5 11 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.26826982143488e-09 9.39972893698873e-09 0.890943571192862 0.951219512195122 11.5 11 5 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.71094012395045e-13 1.87282138183192e-12 0.889801335845179 0.95 11.5 11 5 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.71094012395045e-13 1.87282138183192e-12 0.889801335845179 0.95 11.5 11 5 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.71094012395045e-13 1.87282138183192e-12 0.889801335845179 0.95 11.5 11 5 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.71094012395045e-13 1.87282138183192e-12 0.889801335845179 0.95 11.5 11 5 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.71094012395045e-13 1.87282138183192e-12 0.889801335845179 0.95 11.5 11 5 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.71094012395045e-13 1.87282138183192e-12 0.889801335845179 0.95 11.5 11 5 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.71094012395045e-13 1.87282138183192e-12 0.889801335845179 0.95 11.5 11 5 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 3.56785382347012e-05 0.000128533063058177 0.889801335845179 0.95 11.5 11 5 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 3.56785382347012e-05 0.000128533063058177 0.889801335845179 0.95 11.5 11 5 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 3.56785382347012e-05 0.000128533063058177 0.889801335845179 0.95 11.5 11 5 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 3.56785382347012e-05 0.000128533063058177 0.889801335845179 0.95 11.5 11 5 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 6.58473235453889e-05 0.000226330293249006 0.887336512200179 0.947368421052632 11.5 11 5 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.46311850992543e-08 9.59455133467226e-08 0.886004175094773 0.945945945945946 11.5 11 5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.46311850992543e-08 9.59455133467226e-08 0.886004175094773 0.945945945945946 11.5 11 5 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.46311850992543e-08 9.59455133467226e-08 0.886004175094773 0.945945945945946 11.5 11 5 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 6.64049190306155e-12 6.17609148892587e-11 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.71554803821015e-15 3.17042189399097e-14 0.884597819261289 0.944444444444444 11.5 11 5 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000121220881401809 0.000396580404121413 0.884597819261289 0.944444444444444 11.5 11 5 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000121220881401809 0.000396580404121413 0.884597819261289 0.944444444444444 11.5 11 5 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000121220881401809 0.000396580404121413 0.884597819261289 0.944444444444444 11.5 11 5 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000121220881401809 0.000396580404121413 0.884597819261289 0.944444444444444 11.5 11 5 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 4.92809947230998e-08 2.77181246999885e-07 0.88311110023732 0.942857142857143 11.5 11 5 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 4.92809947230998e-08 2.77181246999885e-07 0.88311110023732 0.942857142857143 11.5 11 5 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.000222540264724527 0.00068693014469198 0.881536927153118 0.941176470588235 11.5 11 5 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000222540264724527 0.00068693014469198 0.881536927153118 0.941176470588235 11.5 11 5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000222540264724527 0.00068693014469198 0.881536927153118 0.941176470588235 11.5 11 5 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000222540264724527 0.00068693014469198 0.881536927153118 0.941176470588235 11.5 11 5 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000222540264724527 0.00068693014469198 0.881536927153118 0.941176470588235 11.5 11 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.08058983336646e-11 3.57395524073556e-10 0.881536927153118 0.941176470588235 11.5 11 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.08058983336646e-11 3.57395524073556e-10 0.881536927153118 0.941176470588235 11.5 11 5 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 3.00921571719404e-07 1.43695099515675e-06 0.878093423531426 0.9375 11.5 11 5 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00040728211367347 0.00117320333554119 0.878093423531426 0.9375 11.5 11 5 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00040728211367347 0.00117320333554119 0.878093423531426 0.9375 11.5 11 5 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00040728211367347 0.00117320333554119 0.878093423531426 0.9375 11.5 11 5 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00040728211367347 0.00117320333554119 0.878093423531426 0.9375 11.5 11 5 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00040728211367347 0.00117320333554119 0.878093423531426 0.9375 11.5 11 5 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00040728211367347 0.00117320333554119 0.878093423531426 0.9375 11.5 11 5 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00040728211367347 0.00117320333554119 0.878093423531426 0.9375 11.5 11 5 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.02291535466018e-18 3.55026475532058e-17 0.876205050577596 0.935483870967742 11.5 11 5 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 3.75742945961382e-15 6.07593422844371e-14 0.874190786093509 0.933333333333333 11.5 11 5 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 3.75742945961382e-15 6.07593422844371e-14 0.874190786093509 0.933333333333333 11.5 11 5 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 3.75742945961382e-15 6.07593422844371e-14 0.874190786093509 0.933333333333333 11.5 11 5 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 3.75742945961382e-15 6.07593422844371e-14 0.874190786093509 0.933333333333333 11.5 11 5 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 3.75742945961382e-15 6.07593422844371e-14 0.874190786093509 0.933333333333333 11.5 11 5 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000742808163537824 0.00202493489792016 0.874190786093509 0.933333333333333 11.5 11 5 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000742808163537824 0.00202493489792016 0.874190786093509 0.933333333333333 11.5 11 5 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000742808163537824 0.00202493489792016 0.874190786093509 0.933333333333333 11.5 11 5 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000742808163537824 0.00202493489792016 0.874190786093509 0.933333333333333 11.5 11 5 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000742808163537824 0.00202493489792016 0.874190786093509 0.933333333333333 11.5 11 5 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.49079182989255e-09 1.0878957815062e-08 0.874190786093509 0.933333333333333 11.5 11 5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.70234450458235e-09 1.91315235324412e-08 0.872771645206994 0.931818181818182 11.5 11 5 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.49112416542153e-30 1.51562120528203e-28 0.87223946737455 0.93125 11.5 11 5 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 1.80616989599717e-06 7.7886993807835e-06 0.872037606817417 0.931034482758621 11.5 11 5 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 1.80616989599717e-06 7.7886993807835e-06 0.872037606817417 0.931034482758621 11.5 11 5 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.9612134965581e-19 7.97373373029194e-18 0.871068676143175 0.93 11.5 11 5 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 6.39840378742655e-19 2.33459707423282e-17 0.869730629021603 0.928571428571429 11.5 11 5 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 3.26796271672213e-06 1.3677385134987e-05 0.869730629021603 0.928571428571429 11.5 11 5 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00134946165054233 0.00335713973552751 0.869730629021603 0.928571428571429 11.5 11 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00134946165054233 0.00335713973552751 0.869730629021603 0.928571428571429 11.5 11 5 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00134946165054233 0.00335713973552751 0.869730629021603 0.928571428571429 11.5 11 5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00134946165054233 0.00335713973552751 0.869730629021603 0.928571428571429 11.5 11 5 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00134946165054233 0.00335713973552751 0.869730629021603 0.928571428571429 11.5 11 5 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00134946165054233 0.00335713973552751 0.869730629021603 0.928571428571429 11.5 11 5 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00134946165054233 0.00335713973552751 0.869730629021603 0.928571428571429 11.5 11 5 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.31346907118466e-13 1.51956625064696e-12 0.868761029658146 0.927536231884058 11.5 11 5 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.59408295038622e-08 1.02641630696814e-07 0.868098864239199 0.926829268292683 11.5 11 5 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.59408295038622e-08 1.02641630696814e-07 0.868098864239199 0.926829268292683 11.5 11 5 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.59408295038622e-08 1.02641630696814e-07 0.868098864239199 0.926829268292683 11.5 11 5 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.59408295038622e-08 1.02641630696814e-07 0.868098864239199 0.926829268292683 11.5 11 5 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 5.89829202182003e-06 2.41880966773772e-05 0.867252763981656 0.925925925925926 11.5 11 5 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 5.89829202182003e-06 2.41880966773772e-05 0.867252763981656 0.925925925925926 11.5 11 5 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 4.25830941732782e-13 4.39099587018659e-12 0.866735001137488 0.925373134328358 11.5 11 5 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 4.25830941732782e-13 4.39099587018659e-12 0.866735001137488 0.925373134328358 11.5 11 5 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.87026889434451e-08 1.69476872890135e-07 0.866385511217674 0.925 11.5 11 5 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 2.87026889434451e-08 1.69476872890135e-07 0.866385511217674 0.925 11.5 11 5 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.0644067949251e-15 6.31782301090376e-14 0.865496302687516 0.924050632911392 11.5 11 5 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.0644067949251e-15 6.31782301090376e-14 0.865496302687516 0.924050632911392 11.5 11 5 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 1.06176544998749e-05 4.16223756289861e-05 0.864584293938635 0.923076923076923 11.5 11 5 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.06176544998749e-05 4.16223756289861e-05 0.864584293938635 0.923076923076923 11.5 11 5 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 1.06176544998749e-05 4.16223756289861e-05 0.864584293938635 0.923076923076923 11.5 11 5 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.06176544998749e-05 4.16223756289861e-05 0.864584293938635 0.923076923076923 11.5 11 5 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00244070520004327 0.00579820283749846 0.864584293938635 0.923076923076923 11.5 11 5 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00244070520004327 0.00579820283749846 0.864584293938635 0.923076923076923 11.5 11 5 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00244070520004327 0.00579820283749846 0.864584293938635 0.923076923076923 11.5 11 5 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00244070520004327 0.00579820283749846 0.864584293938635 0.923076923076923 11.5 11 5 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00244070520004327 0.00579820283749846 0.864584293938635 0.923076923076923 11.5 11 5 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00244070520004327 0.00579820283749846 0.864584293938635 0.923076923076923 11.5 11 5 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00244070520004327 0.00579820283749846 0.864584293938635 0.923076923076923 11.5 11 5 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 1.90588932163283e-05 7.3101900395782e-05 0.861702346292173 0.92 11.5 11 5 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 1.90588932163283e-05 7.3101900395782e-05 0.861702346292173 0.92 11.5 11 5 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.28300059727136e-15 3.17042189399097e-14 0.859498503974291 0.917647058823529 11.5 11 5 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 3.41064832219944e-05 0.000124126664002297 0.858580236341839 0.916666666666667 11.5 11 5 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 3.41064832219944e-05 0.000124126664002297 0.858580236341839 0.916666666666667 11.5 11 5 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 3.41064832219944e-05 0.000124126664002297 0.858580236341839 0.916666666666667 11.5 11 5 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 3.41064832219944e-05 0.000124126664002297 0.858580236341839 0.916666666666667 11.5 11 5 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00439195672736805 0.00967454245053364 0.858580236341839 0.916666666666667 11.5 11 5 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 2.95773823677992e-07 1.41712508785785e-06 0.858580236341839 0.916666666666667 11.5 11 5 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.95773823677992e-07 1.41712508785785e-06 0.858580236341839 0.916666666666667 11.5 11 5 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.4762088737392e-11 3.8603910468672e-10 0.857257308396783 0.915254237288136 11.5 11 5 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.4762088737392e-11 3.8603910468672e-10 0.857257308396783 0.915254237288136 11.5 11 5 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.7932351835575e-09 3.27921810875112e-08 0.856919539559747 0.914893617021277 11.5 11 5 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.7932351835575e-09 3.27921810875112e-08 0.856919539559747 0.914893617021277 11.5 11 5 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.7932351835575e-09 3.27921810875112e-08 0.856919539559747 0.914893617021277 11.5 11 5 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.28795530366222e-14 1.83276039711134e-13 0.855689393795234 0.91358024691358 11.5 11 5 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.28795530366222e-14 1.83276039711134e-13 0.855689393795234 0.91358024691358 11.5 11 5 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.14716403535187e-18 6.94412368705843e-17 0.855578207543441 0.913461538461538 11.5 11 5 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 6.08328126359219e-05 0.000210109447526497 0.855186638569737 0.91304347826087 11.5 11 5 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.28617315995116e-14 3.1894356927554e-13 0.854677598903922 0.9125 11.5 11 5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.38087960957514e-12 2.28918357055772e-11 0.853988898179584 0.911764705882353 11.5 11 5 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.05330486986932e-14 5.59985711633402e-13 0.85364018895207 0.911392405063291 11.5 11 5 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 7.17775052713572e-14 9.4573509260316e-13 0.852576178745043 0.91025641025641 11.5 11 5 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00785666255808821 0.0161561139019646 0.851484531909262 0.909090909090909 11.5 11 5 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 3.95605867460464e-13 4.16997888441659e-12 0.849213906490838 0.906666666666667 11.5 11 5 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.19550967098709e-14 1.75382501218003e-13 0.848479292384877 0.905882352941176 11.5 11 5 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.19550967098709e-14 1.75382501218003e-13 0.848479292384877 0.905882352941176 11.5 11 5 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 4.09384894054741e-11 3.57395524073556e-10 0.847429843662075 0.904761904761905 11.5 11 5 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00019138983311192 0.000603875238399696 0.847429843662075 0.904761904761905 11.5 11 5 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00019138983311192 0.000603875238399696 0.847429843662075 0.904761904761905 11.5 11 5 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00019138983311192 0.000603875238399696 0.847429843662075 0.904761904761905 11.5 11 5 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 6.4974738713625e-14 8.6410330083634e-13 0.845254157285536 0.902439024390244 11.5 11 5 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.77969688622068e-12 3.56192627092187e-11 0.844288887977635 0.901408450704225 11.5 11 5 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 4.16493010217135e-33 5.92669553538984e-31 0.84296968659017 0.9 11.5 11 5 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.27292446319025e-21 2.42044242294185e-19 0.84296968659017 0.9 11.5 11 5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 9.09808442214865e-06 3.67800401497657e-05 0.84296968659017 0.9 11.5 11 5 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.000337366391341579 0.00100644103748232 0.84296968659017 0.9 11.5 11 5 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.013957695272339 0.0265887555187931 0.84296968659017 0.9 11.5 11 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.013957695272339 0.0265887555187931 0.84296968659017 0.9 11.5 11 5 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.013957695272339 0.0265887555187931 0.84296968659017 0.9 11.5 11 5 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.013957695272339 0.0265887555187931 0.84296968659017 0.9 11.5 11 5 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.013957695272339 0.0265887555187931 0.84296968659017 0.9 11.5 11 5 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.013957695272339 0.0265887555187931 0.84296968659017 0.9 11.5 11 5 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.013957695272339 0.0265887555187931 0.84296968659017 0.9 11.5 11 5 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 9.83602212142697e-18 2.91597072474804e-16 0.842110390273564 0.899082568807339 11.5 11 5 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.31006786535489e-08 8.7113391233645e-08 0.84105819070221 0.897959183673469 11.5 11 5 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 4.50740454200555e-07 2.12385319975957e-06 0.840568063551451 0.897435897435897 11.5 11 5 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 6.76263281248994e-10 5.25859371157004e-09 0.839739917676031 0.896551724137931 11.5 11 5 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 6.76263281248994e-10 5.25859371157004e-09 0.839739917676031 0.896551724137931 11.5 11 5 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 2.28716535586098e-08 1.44650502284008e-07 0.839067049152252 0.895833333333333 11.5 11 5 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 5.62035188775535e-14 7.61691498692939e-13 0.838613254101331 0.895348837209302 11.5 11 5 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.85214463397078e-12 1.80520672201399e-11 0.838040039300169 0.894736842105263 11.5 11 5 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000591896123181379 0.00167116703033155 0.838040039300169 0.894736842105263 11.5 11 5 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000591896123181379 0.00167116703033155 0.838040039300169 0.894736842105263 11.5 11 5 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 9.78058138552319e-14 1.27685938638528e-12 0.837460080795463 0.894117647058824 11.5 11 5 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.0500274991062e-09 1.45859456561406e-08 0.836279450982311 0.892857142857143 11.5 11 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 2.78177028976358e-05 0.000103896564890645 0.836279450982311 0.892857142857143 11.5 11 5 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 2.78177028976358e-05 0.000103896564890645 0.836279450982311 0.892857142857143 11.5 11 5 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.78177028976358e-05 0.000103896564890645 0.836279450982311 0.892857142857143 11.5 11 5 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 6.92337302498984e-08 3.68987258972305e-07 0.834825051937124 0.891304347826087 11.5 11 5 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 6.92337302498984e-08 3.68987258972305e-07 0.834825051937124 0.891304347826087 11.5 11 5 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 6.92337302498984e-08 3.68987258972305e-07 0.834825051937124 0.891304347826087 11.5 11 5 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 5.11185686083035e-13 5.23321749133928e-12 0.833831803808704 0.890243902439024 11.5 11 5 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 7.66332657345032e-17 2.09709879115765e-15 0.833517427107507 0.889908256880734 11.5 11 5 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.68386854053059e-14 6.40879320497598e-13 0.83256265342239 0.888888888888889 11.5 11 5 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 8.84581235434895e-13 8.74138262516566e-12 0.83256265342239 0.888888888888889 11.5 11 5 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.20310454781018e-10 2.58978282473516e-09 0.83256265342239 0.888888888888889 11.5 11 5 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.2001824404228e-07 6.1655581686702e-07 0.83256265342239 0.888888888888889 11.5 11 5 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.37705579654527e-06 1.01578090044562e-05 0.83256265342239 0.888888888888889 11.5 11 5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.37705579654527e-06 1.01578090044562e-05 0.83256265342239 0.888888888888889 11.5 11 5 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 4.83725543243141e-05 0.000171179446611328 0.83256265342239 0.888888888888889 11.5 11 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 4.83725543243141e-05 0.000171179446611328 0.83256265342239 0.888888888888889 11.5 11 5 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 4.83725543243141e-05 0.000171179446611328 0.83256265342239 0.888888888888889 11.5 11 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 4.83725543243141e-05 0.000171179446611328 0.83256265342239 0.888888888888889 11.5 11 5 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00103309533130628 0.00271736535387954 0.83256265342239 0.888888888888889 11.5 11 5 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00103309533130628 0.00271736535387954 0.83256265342239 0.888888888888889 11.5 11 5 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00103309533130628 0.00271736535387954 0.83256265342239 0.888888888888889 11.5 11 5 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0245933330085885 0.0437453910890267 0.83256265342239 0.888888888888889 11.5 11 5 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.0752017244864e-07 1.01130549792608e-06 0.830197418611531 0.886363636363636 11.5 11 5 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.0752017244864e-07 1.01130549792608e-06 0.830197418611531 0.886363636363636 11.5 11 5 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.94726429953873e-18 6.44408627498513e-17 0.83002435264976 0.886178861788618 11.5 11 5 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.63689559535984e-12 2.51832377999803e-11 0.82992796148118 0.886075949367089 11.5 11 5 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.40612656228131e-13 2.59387734706538e-12 0.828974021295569 0.885057471264368 11.5 11 5 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.40612656228131e-13 2.59387734706538e-12 0.828974021295569 0.885057471264368 11.5 11 5 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.65948647371453e-20 7.37952891279928e-19 0.828819116311678 0.884892086330935 11.5 11 5 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 8.37750567091371e-05 0.000281824836163362 0.828559948357859 0.884615384615385 11.5 11 5 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 8.37750567091371e-05 0.000281824836163362 0.828559948357859 0.884615384615385 11.5 11 5 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 8.61335553192212e-11 7.21397017648648e-10 0.82803785639292 0.884057971014493 11.5 11 5 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 8.61335553192212e-11 7.21397017648648e-10 0.82803785639292 0.884057971014493 11.5 11 5 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 4.13983255685576e-13 4.33160421206304e-12 0.827722172879236 0.883720930232558 11.5 11 5 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 7.09134995325134e-06 2.88314028099333e-05 0.826440869206049 0.882352941176471 11.5 11 5 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 7.09134995325134e-06 2.88314028099333e-05 0.826440869206049 0.882352941176471 11.5 11 5 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00179284598079055 0.00439108404589492 0.826440869206049 0.882352941176471 11.5 11 5 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00179284598079055 0.00439108404589492 0.826440869206049 0.882352941176471 11.5 11 5 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00179284598079055 0.00439108404589492 0.826440869206049 0.882352941176471 11.5 11 5 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00179284598079055 0.00439108404589492 0.826440869206049 0.882352941176471 11.5 11 5 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00179284598079055 0.00439108404589492 0.826440869206049 0.882352941176471 11.5 11 5 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00179284598079055 0.00439108404589492 0.826440869206049 0.882352941176471 11.5 11 5 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 3.16152852225899e-08 1.82880288096526e-07 0.826440869206049 0.882352941176471 11.5 11 5 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.16152852225899e-08 1.82880288096526e-07 0.826440869206049 0.882352941176471 11.5 11 5 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.18284463943148e-16 8.38738504057591e-15 0.825939995951984 0.881818181818182 11.5 11 5 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.3411006280785e-11 1.22332448317674e-10 0.825715921075166 0.881578947368421 11.5 11 5 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 6.15359261967113e-07 2.83383893132428e-06 0.825129058302547 0.880952380952381 11.5 11 5 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000144455476596879 0.00046931539542776 0.824237026888166 0.88 11.5 11 5 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.08951616120966e-12 2.02270850163356e-11 0.823785637497756 0.879518072289157 11.5 11 5 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 1.21849174572625e-05 4.75044864155742e-05 0.823101714178953 0.878787878787879 11.5 11 5 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 3.93291225548515e-11 3.4978338372221e-10 0.822718162588003 0.878378378378378 11.5 11 5 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 3.93291225548515e-11 3.4978338372221e-10 0.822718162588003 0.878378378378378 11.5 11 5 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.05504411634328e-06 4.67703357494232e-06 0.822409450331873 0.878048780487805 11.5 11 5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.05504411634328e-06 4.67703357494232e-06 0.822409450331873 0.878048780487805 11.5 11 5 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 1.05504411634328e-06 4.67703357494232e-06 0.822409450331873 0.878048780487805 11.5 11 5 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.71711188549893e-11 5.72362288207484e-10 0.821157685567288 0.876712328767123 11.5 11 5 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000247917118533413 0.000757051630199672 0.819553861962665 0.875 11.5 11 5 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000247917118533413 0.000757051630199672 0.819553861962665 0.875 11.5 11 5 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000247917118533413 0.000757051630199672 0.819553861962665 0.875 11.5 11 5 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000247917118533413 0.000757051630199672 0.819553861962665 0.875 11.5 11 5 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.14511747036449e-10 9.47384976935269e-10 0.819553861962665 0.875 11.5 11 5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.14511747036449e-10 9.47384976935269e-10 0.819553861962665 0.875 11.5 11 5 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00309149051258827 0.00704998557598255 0.819553861962665 0.875 11.5 11 5 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00309149051258827 0.00704998557598255 0.819553861962665 0.875 11.5 11 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00309149051258827 0.00704998557598255 0.819553861962665 0.875 11.5 11 5 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00309149051258827 0.00704998557598255 0.819553861962665 0.875 11.5 11 5 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00309149051258827 0.00704998557598255 0.819553861962665 0.875 11.5 11 5 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00309149051258827 0.00704998557598255 0.819553861962665 0.875 11.5 11 5 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0429045280755293 0.0697750210874037 0.819553861962665 0.875 11.5 11 5 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.04805781913045e-17 3.04364546249516e-16 0.818631979103314 0.874015748031496 11.5 11 5 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.94847070843319e-10 1.60270162895979e-09 0.817904860228334 0.873239436619718 11.5 11 5 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.78690333708989e-18 8.81280766373092e-17 0.816912979485879 0.87218045112782 11.5 11 5 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 3.07223127162458e-06 1.28961212375273e-05 0.816551833164267 0.871794871794872 11.5 11 5 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.66272356628855e-09 2.54246616333103e-08 0.815777116055003 0.870967741935484 11.5 11 5 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 3.66272356628855e-09 2.54246616333103e-08 0.815777116055003 0.870967741935484 11.5 11 5 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.58581669324833e-07 2.14658459029355e-06 0.814463465304512 0.869565217391304 11.5 11 5 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 4.58581669324833e-07 2.14658459029355e-06 0.814463465304512 0.869565217391304 11.5 11 5 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00042331466976748 0.00121446930459501 0.814463465304512 0.869565217391304 11.5 11 5 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00042331466976748 0.00121446930459501 0.814463465304512 0.869565217391304 11.5 11 5 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.02466497770119e-14 1.53484027712504e-13 0.814082874900164 0.869158878504673 11.5 11 5 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 7.85989807678275e-12 7.21589352468507e-11 0.813978665622783 0.869047619047619 11.5 11 5 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 7.85989807678275e-12 7.21589352468507e-11 0.813978665622783 0.869047619047619 11.5 11 5 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 6.20558287467555e-09 4.20502115745872e-08 0.813795872300164 0.868852459016393 11.5 11 5 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 8.6182356289719e-11 7.21397017648648e-10 0.813391802850164 0.868421052631579 11.5 11 5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.04893436254747e-08 7.04072451842002e-08 0.81174858708683 0.866666666666667 11.5 11 5 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00529270931607163 0.0112410826220447 0.81174858708683 0.866666666666667 11.5 11 5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00529270931607163 0.0112410826220447 0.81174858708683 0.866666666666667 11.5 11 5 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.00529270931607163 0.0112410826220447 0.81174858708683 0.866666666666667 11.5 11 5 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00529270931607163 0.0112410826220447 0.81174858708683 0.866666666666667 11.5 11 5 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00529270931607163 0.0112410826220447 0.81174858708683 0.866666666666667 11.5 11 5 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00529270931607163 0.0112410826220447 0.81174858708683 0.866666666666667 11.5 11 5 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.60081837923609e-09 1.15632718459541e-08 0.810816613967327 0.865671641791045 11.5 11 5 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.57775674940483e-21 1.69704928480102e-19 0.810216263184826 0.865030674846626 11.5 11 5 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 5.58543028554853e-22 3.17922691853422e-20 0.809912051821928 0.864705882352941 11.5 11 5 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.51440589170676e-34 5.55666620433191e-32 0.809223351097589 0.863970588235294 11.5 11 5 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 9.39750039207027e-22 4.77594394925571e-20 0.809162223814364 0.863905325443787 11.5 11 5 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000718809428641094 0.00197846386258468 0.808910305313799 0.863636363636364 11.5 11 5 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000718809428641094 0.00197846386258468 0.808910305313799 0.863636363636364 11.5 11 5 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000718809428641094 0.00197846386258468 0.808910305313799 0.863636363636364 11.5 11 5 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.28648823520287e-14 1.83276039711134e-13 0.808910305313799 0.863636363636364 11.5 11 5 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 4.12757704579638e-10 3.29974277312823e-09 0.808327096730299 0.863013698630137 11.5 11 5 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.9751005194951e-08 1.73506886854161e-07 0.807442228534645 0.862068965517241 11.5 11 5 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.9751005194951e-08 1.73506886854161e-07 0.807442228534645 0.862068965517241 11.5 11 5 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.30463654833458e-52 1.50969956165602e-49 0.806911515332791 0.86150234741784 11.5 11 5 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 6.92926078445919e-10 5.35887940015513e-09 0.80654507050294 0.861111111111111 11.5 11 5 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.48722700528663e-05 5.75088051229042e-05 0.80654507050294 0.861111111111111 11.5 11 5 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 3.91593207644036e-13 4.15848607819002e-12 0.805504367186162 0.86 11.5 11 5 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 6.06919188596959e-14 8.14760382427805e-13 0.805329295600162 0.85981308411215 11.5 11 5 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.4635714842027e-15 3.17042189399097e-14 0.805039921077848 0.859504132231405 11.5 11 5 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.4635714842027e-15 3.17042189399097e-14 0.805039921077848 0.859504132231405 11.5 11 5 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 6.54984005936586e-13 6.65744457462688e-12 0.804179835692081 0.858585858585859 11.5 11 5 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 4.08460799018374e-15 6.31782301090376e-14 0.802828272943019 0.857142857142857 11.5 11 5 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 5.52948300223598e-07 2.55469295850058e-06 0.802828272943019 0.857142857142857 11.5 11 5 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 3.69315324260031e-06 1.5366541123451e-05 0.802828272943019 0.857142857142857 11.5 11 5 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 3.69315324260031e-06 1.5366541123451e-05 0.802828272943019 0.857142857142857 11.5 11 5 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00121322574071953 0.00317356659750716 0.802828272943019 0.857142857142857 11.5 11 5 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00121322574071953 0.00317356659750716 0.802828272943019 0.857142857142857 11.5 11 5 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00898816649704893 0.018142072234469 0.802828272943019 0.857142857142857 11.5 11 5 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.00898816649704893 0.018142072234469 0.802828272943019 0.857142857142857 11.5 11 5 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00898816649704893 0.018142072234469 0.802828272943019 0.857142857142857 11.5 11 5 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.00898816649704893 0.018142072234469 0.802828272943019 0.857142857142857 11.5 11 5 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00898816649704893 0.018142072234469 0.802828272943019 0.857142857142857 11.5 11 5 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0739371464527817 0.112047454102565 0.802828272943019 0.857142857142857 11.5 11 5 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.94028968419315e-09 1.38745337718937e-08 0.802828272943019 0.857142857142857 11.5 11 5 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 2.49644363465535e-05 9.47317144563882e-05 0.802828272943019 0.857142857142857 11.5 11 5 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.49644363465535e-05 9.47317144563882e-05 0.802828272943019 0.857142857142857 11.5 11 5 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.43229282564139e-61 6.79384230295897e-59 0.801301983450732 0.855513307984791 11.5 11 5 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 3.23593356466013e-09 2.26834160714846e-08 0.800889074216103 0.855072463768116 11.5 11 5 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.11801988018432e-08 1.34550995067067e-07 0.800670132424355 0.854838709677419 11.5 11 5 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.39351303260631e-07 6.93345820069503e-07 0.800395459994706 0.854545454545454 11.5 11 5 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.39351303260631e-07 6.93345820069503e-07 0.800395459994706 0.854545454545454 11.5 11 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.39351303260631e-07 6.93345820069503e-07 0.800395459994706 0.854545454545454 11.5 11 5 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.39351303260631e-07 6.93345820069503e-07 0.800395459994706 0.854545454545454 11.5 11 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.39351303260631e-07 6.93345820069503e-07 0.800395459994706 0.854545454545454 11.5 11 5 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 9.22999068042203e-07 4.18289068096833e-06 0.800040674773078 0.854166666666667 11.5 11 5 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 4.41952074265342e-22 2.62040750699826e-20 0.799192275330052 0.853260869565217 11.5 11 5 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.47982767149376e-34 4.41099347066952e-32 0.799174901962618 0.853242320819113 11.5 11 5 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 7.33910845007617e-22 3.86798197202163e-20 0.798441233200161 0.852459016393443 11.5 11 5 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 7.33910845007617e-22 3.86798197202163e-20 0.798441233200161 0.852459016393443 11.5 11 5 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.31849932856989e-07 1.12601520291978e-06 0.797872542863123 0.851851851851852 11.5 11 5 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000287339445421872 0.000864448268150791 0.797872542863123 0.851851851851852 11.5 11 5 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000287339445421872 0.000864448268150791 0.797872542863123 0.851851851851852 11.5 11 5 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 5.84771437411484e-08 3.20049905937131e-07 0.79613803733516 0.85 11.5 11 5 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.02628344941479e-05 4.11380661554153e-05 0.79613803733516 0.85 11.5 11 5 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.02628344941479e-05 4.11380661554153e-05 0.79613803733516 0.85 11.5 11 5 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.00203423127027358 0.00492297805714168 0.79613803733516 0.85 11.5 11 5 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00203423127027358 0.00492297805714168 0.79613803733516 0.85 11.5 11 5 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00203423127027358 0.00492297805714168 0.79613803733516 0.85 11.5 11 5 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00203423127027358 0.00492297805714168 0.79613803733516 0.85 11.5 11 5 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00203423127027358 0.00492297805714168 0.79613803733516 0.85 11.5 11 5 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.00203423127027358 0.00492297805714168 0.79613803733516 0.85 11.5 11 5 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 3.84596671431e-07 1.82427021148771e-06 0.795254421311481 0.849056603773585 11.5 11 5 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 6.9434123153127e-05 0.000238083752402168 0.794718896448645 0.848484848484849 11.5 11 5 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 9.67704027067583e-08 5.08133885799694e-07 0.793756767034058 0.847457627118644 11.5 11 5 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.69504438746185e-29 1.50753010209889e-27 0.793087700027363 0.846743295019157 11.5 11 5 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.44409984253652e-08 1.53504189726474e-07 0.792535602777083 0.846153846153846 11.5 11 5 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.000478197785979459 0.00136367825540836 0.792535602777082 0.846153846153846 11.5 11 5 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.000478197785979459 0.00136367825540836 0.792535602777082 0.846153846153846 11.5 11 5 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000478197785979459 0.00136367825540836 0.792535602777082 0.846153846153846 11.5 11 5 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0151238401276544 0.0283547094883428 0.792535602777082 0.846153846153846 11.5 11 5 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0151238401276544 0.0283547094883428 0.792535602777082 0.846153846153846 11.5 11 5 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0151238401276544 0.0283547094883428 0.792535602777082 0.846153846153846 11.5 11 5 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0151238401276544 0.0283547094883428 0.792535602777082 0.846153846153846 11.5 11 5 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0151238401276544 0.0283547094883428 0.792535602777082 0.846153846153846 11.5 11 5 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.97870807815724e-15 6.31782301090376e-14 0.791418568805586 0.844961240310077 11.5 11 5 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 4.02606873131616e-08 2.29163832186516e-07 0.790284081178284 0.84375 11.5 11 5 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 4.02606873131616e-08 2.29163832186516e-07 0.790284081178284 0.84375 11.5 11 5 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.50141913704611e-18 1.39250422435144e-16 0.789363647820285 0.842767295597484 11.5 11 5 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.86697803434932e-17 7.99943086839037e-16 0.788743566400159 0.842105263157895 11.5 11 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.00338615777463906 0.00764841668779585 0.788743566400159 0.842105263157895 11.5 11 5 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00338615777463906 0.00764841668779585 0.788743566400159 0.842105263157895 11.5 11 5 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 6.61401321264229e-08 3.5650533339356e-07 0.787961082703333 0.841269841269841 11.5 11 5 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.20910691041785e-17 3.4411182670492e-16 0.787487605307165 0.840764331210191 11.5 11 5 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.67115433872549e-08 1.07119487567855e-07 0.787314683127695 0.840579710144927 11.5 11 5 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.72225956849483e-06 7.54084727990196e-06 0.786771707484158 0.84 11.5 11 5 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00079109073870022 0.00213609510658522 0.786771707484158 0.84 11.5 11 5 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00079109073870022 0.00213609510658522 0.786771707484158 0.84 11.5 11 5 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 4.30940123165711e-07 2.03730164539803e-06 0.786102683923372 0.839285714285714 11.5 11 5 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.000189463593003961 0.000603875238399696 0.785563148793706 0.838709677419355 11.5 11 5 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.000189463593003961 0.000603875238399696 0.785563148793706 0.838709677419355 11.5 11 5 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.99273003699232e-24 3.15647491257782e-22 0.785427660151279 0.838565022421525 11.5 11 5 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 1.13552088083416e-05 4.4391379489753e-05 0.784157847990855 0.837209302325581 11.5 11 5 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 7.04620706349472e-07 3.23443633914612e-06 0.783365769356521 0.836363636363636 11.5 11 5 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.76986774207537e-07 8.71460829402508e-07 0.783086594100157 0.836065573770492 11.5 11 5 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.76986774207537e-07 8.71460829402508e-07 0.783086594100157 0.836065573770492 11.5 11 5 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.46369357606038e-08 2.53061193575056e-07 0.782857420382247 0.835820895522388 11.5 11 5 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.11822010313111e-15 3.76778400844446e-14 0.782757566119443 0.835714285714286 11.5 11 5 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.11822010313111e-15 3.76778400844446e-14 0.782757566119443 0.835714285714286 11.5 11 5 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.86600529316033e-09 2.01897303572631e-08 0.782503506539398 0.835443037974684 11.5 11 5 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.4444657556832e-15 5.90539128956289e-14 0.781650548716704 0.834532374100719 11.5 11 5 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.1775805413608e-14 3.06801694094694e-13 0.78052748758349 0.833333333333333 11.5 11 5 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.14833036430105e-06 5.07476431180246e-06 0.78052748758349 0.833333333333333 11.5 11 5 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 7.54252678149891e-05 0.000257386465469375 0.78052748758349 0.833333333333333 11.5 11 5 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 7.54252678149891e-05 0.000257386465469375 0.78052748758349 0.833333333333333 11.5 11 5 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00130030242593781 0.00335713973552751 0.78052748758349 0.833333333333333 11.5 11 5 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00130030242593781 0.00335713973552751 0.78052748758349 0.833333333333333 11.5 11 5 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00559159922821187 0.0118054090530349 0.78052748758349 0.833333333333333 11.5 11 5 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00559159922821187 0.0118054090530349 0.78052748758349 0.833333333333333 11.5 11 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00559159922821187 0.0118054090530349 0.78052748758349 0.833333333333333 11.5 11 5 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0251801917116891 0.0445664338379771 0.78052748758349 0.833333333333333 11.5 11 5 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0251801917116891 0.0445664338379771 0.78052748758349 0.833333333333333 11.5 11 5 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0251801917116891 0.0445664338379771 0.78052748758349 0.833333333333333 11.5 11 5 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0251801917116891 0.0445664338379771 0.78052748758349 0.833333333333333 11.5 11 5 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%REACT_226440.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_223937.1 FGFR2B LIGAND BINDING AND ACTIVATION 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 VITAMINS%REACTOME%REACT_213027.1 VITAMINS 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 KLOTHO-MEDIATED LIGAND BINDING%REACTOME%REACT_222862.1 KLOTHO-MEDIATED LIGAND BINDING 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME DATABASE ID RELEASE 48%5605065 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.125454472572077 0.183099194328272 0.78052748758349 0.833333333333333 11.5 11 5 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.21302827440173e-23 5.84356961723683e-21 0.779108346696975 0.831818181818182 11.5 11 5 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.92224815056612e-09 1.38149450416949e-08 0.778646698456783 0.831325301204819 11.5 11 5 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.38569702350865e-12 3.21189790963521e-11 0.777739889413549 0.830357142857143 11.5 11 5 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.59928065227343e-13 3.85095967532714e-12 0.776720036424546 0.829268292682927 11.5 11 5 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.01513758120231e-05 0.000111732832761742 0.776720036424546 0.829268292682927 11.5 11 5 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 3.01513758120231e-05 0.000111732832761742 0.776720036424546 0.829268292682927 11.5 11 5 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.18169924358155e-21 1.07053724952295e-19 0.776067330511585 0.828571428571429 11.5 11 5 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.27549504094433e-19 5.33832189195229e-18 0.775649190786094 0.828125 11.5 11 5 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.90832002590318e-07 9.36392895469042e-07 0.775649190786093 0.828125 11.5 11 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00050591859878185 0.00143984433213314 0.775144539393259 0.827586206896552 11.5 11 5 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 3.01847092264932e-06 1.27079411921006e-05 0.774523429986694 0.826923076923077 11.5 11 5 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 3.01847092264932e-06 1.27079411921006e-05 0.774523429986694 0.826923076923077 11.5 11 5 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 3.01847092264932e-06 1.27079411921006e-05 0.774523429986694 0.826923076923077 11.5 11 5 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00212240953329075 0.00510167021262288 0.773740292039286 0.826086956521739 11.5 11 5 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 4.88068366684148e-05 0.000171179446611328 0.772722212707655 0.825 11.5 11 5 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.00794357892599e-18 2.42453270485355e-16 0.77258991991315 0.824858757062147 11.5 11 5 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000198731189291924 0.000621526334862436 0.771344811258979 0.823529411764706 11.5 11 5 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000198731189291924 0.000621526334862436 0.771344811258979 0.823529411764706 11.5 11 5 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000198731189291924 0.000621526334862436 0.771344811258979 0.823529411764706 11.5 11 5 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00915183166097763 0.0183682037426956 0.771344811258979 0.823529411764706 11.5 11 5 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.00915183166097763 0.0183682037426956 0.771344811258979 0.823529411764706 11.5 11 5 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00915183166097763 0.0183682037426956 0.771344811258979 0.823529411764706 11.5 11 5 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00915183166097763 0.0183682037426956 0.771344811258979 0.823529411764706 11.5 11 5 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000819273245094315 0.00218319443402474 0.769377094903726 0.821428571428571 11.5 11 5 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.000819273245094315 0.00218319443402474 0.769377094903726 0.821428571428571 11.5 11 5 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000819273245094315 0.00218319443402474 0.769377094903726 0.821428571428571 11.5 11 5 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 5.56701436718462e-10 4.4010341358354e-09 0.769024977240155 0.821052631578947 11.5 11 5 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 7.863242142208e-05 0.000265781319913586 0.768519372389898 0.82051282051282 11.5 11 5 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.28298999161205e-10 1.85639700460797e-09 0.768039047782154 0.82 11.5 11 5 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 8.17485071713827e-08 4.30844910018065e-07 0.767518696123765 0.819444444444444 11.5 11 5 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 8.17485071713827e-08 4.30844910018065e-07 0.767518696123765 0.819444444444444 11.5 11 5 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.04864741183905e-12 1.0291208738255e-11 0.767006538979682 0.818897637795276 11.5 11 5 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000319977683388118 0.000956571940044732 0.766336078718336 0.818181818181818 11.5 11 5 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000319977683388118 0.000956571940044732 0.766336078718336 0.818181818181818 11.5 11 5 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00343809914507249 0.00774116310670594 0.766336078718336 0.818181818181818 11.5 11 5 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.00343809914507249 0.00774116310670594 0.766336078718336 0.818181818181818 11.5 11 5 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0414123424864676 0.0686027512901553 0.766336078718336 0.818181818181818 11.5 11 5 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0414123424864676 0.0686027512901553 0.766336078718336 0.818181818181818 11.5 11 5 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0414123424864676 0.0686027512901553 0.766336078718336 0.818181818181818 11.5 11 5 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0414123424864676 0.0686027512901553 0.766336078718336 0.818181818181818 11.5 11 5 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0414123424864676 0.0686027512901553 0.766336078718336 0.818181818181818 11.5 11 5 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0414123424864676 0.0686027512901553 0.766336078718336 0.818181818181818 11.5 11 5 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0414123424864676 0.0686027512901553 0.766336078718336 0.818181818181818 11.5 11 5 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.20226021462233e-15 5.55709303098484e-14 0.76471933593623 0.816455696202532 11.5 11 5 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0001260556758646 0.000410474203101431 0.764095329950154 0.815789473684211 11.5 11 5 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.50972343389495e-11 2.26033952305856e-10 0.764095329950154 0.815789473684211 11.5 11 5 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.02331177700465e-24 4.51114350456717e-22 0.763716126312461 0.815384615384615 11.5 11 5 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.12855693572955e-07 2.37717801939516e-06 0.763716126312461 0.815384615384615 11.5 11 5 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00131797448443284 0.00335713973552751 0.763182432303857 0.814814814814815 11.5 11 5 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00131797448443284 0.00335713973552751 0.763182432303857 0.814814814814815 11.5 11 5 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.2238560322243e-12 3.95430732490473e-11 0.762902673347734 0.814516129032258 11.5 11 5 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 4.99898157251761e-05 0.000173079094347751 0.762375685546665 0.813953488372093 11.5 11 5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.260213845728e-15 8.03577261631152e-14 0.761014300393903 0.8125 11.5 11 5 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000512193339142126 0.00145479265788272 0.761014300393903 0.8125 11.5 11 5 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0148313241311662 0.027990682014124 0.761014300393903 0.8125 11.5 11 5 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0148313241311662 0.027990682014124 0.761014300393903 0.8125 11.5 11 5 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0148313241311662 0.027990682014124 0.761014300393903 0.8125 11.5 11 5 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0148313241311662 0.027990682014124 0.761014300393903 0.8125 11.5 11 5 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0148313241311662 0.027990682014124 0.761014300393903 0.8125 11.5 11 5 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000201023420928174 0.000627316508729807 0.759432150081234 0.810810810810811 11.5 11 5 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.67424545799138e-11 1.5174848960011e-10 0.758595310246434 0.809917355371901 11.5 11 5 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.38073168212686e-22 1.47294834072458e-20 0.758226702223962 0.80952380952381 11.5 11 5 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.38073168212686e-22 1.47294834072458e-20 0.758226702223962 0.80952380952381 11.5 11 5 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.38073168212686e-22 1.47294834072458e-20 0.758226702223962 0.80952380952381 11.5 11 5 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 7.25890888047361e-19 2.58235683422849e-17 0.758226702223962 0.80952380952381 11.5 11 5 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0055235047708783 0.0117137813546346 0.758226702223962 0.80952380952381 11.5 11 5 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 8.96929785454694e-09 6.04896248673948e-08 0.757725560979928 0.808988764044944 11.5 11 5 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.49030510637131e-09 1.0878957815062e-08 0.7568751394749 0.808080808080808 11.5 11 5 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00210524114012741 0.00506896470795484 0.756511257196306 0.807692307692308 11.5 11 5 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00210524114012741 0.00506896470795484 0.756511257196306 0.807692307692308 11.5 11 5 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00210524114012741 0.00506896470795484 0.756511257196306 0.807692307692308 11.5 11 5 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000814793988948442 0.00218319443402474 0.75534918153241 0.806451612903226 11.5 11 5 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000814793988948442 0.00218319443402474 0.75534918153241 0.806451612903226 11.5 11 5 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.000814793988948442 0.00218319443402474 0.75534918153241 0.806451612903226 11.5 11 5 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000814793988948442 0.00218319443402474 0.75534918153241 0.806451612903226 11.5 11 5 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 3.90623097935817e-10 3.14043315459134e-09 0.754509904664041 0.805555555555556 11.5 11 5 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.2658774632395e-13 1.51956625064696e-12 0.75050719959951 0.801282051282051 11.5 11 5 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 5.44441107505411e-08 2.99127295745251e-07 0.749306388080151 0.8 11.5 11 5 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 5.44441107505411e-08 2.99127295745251e-07 0.749306388080151 0.8 11.5 11 5 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 5.44441107505411e-08 2.99127295745251e-07 0.749306388080151 0.8 11.5 11 5 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 5.44441107505411e-08 2.99127295745251e-07 0.749306388080151 0.8 11.5 11 5 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 5.44441107505411e-08 2.99127295745251e-07 0.749306388080151 0.8 11.5 11 5 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 3.12679812739578e-05 0.00011497244794016 0.749306388080151 0.8 11.5 11 5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 3.12679812739578e-05 0.00011497244794016 0.749306388080151 0.8 11.5 11 5 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.00019793476043674 0.000621526334862436 0.749306388080151 0.8 11.5 11 5 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00128761186374284 0.0033435614636972 0.749306388080151 0.8 11.5 11 5 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.00333714917488816 0.00756172496156983 0.749306388080151 0.8 11.5 11 5 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00333714917488816 0.00756172496156983 0.749306388080151 0.8 11.5 11 5 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00879386379210103 0.0179022434565948 0.749306388080151 0.8 11.5 11 5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00879386379210103 0.0179022434565948 0.749306388080151 0.8 11.5 11 5 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00879386379210103 0.0179022434565948 0.749306388080151 0.8 11.5 11 5 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00879386379210103 0.0179022434565948 0.749306388080151 0.8 11.5 11 5 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00879386379210103 0.0179022434565948 0.749306388080151 0.8 11.5 11 5 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0237699952209582 0.0428703462603594 0.749306388080151 0.8 11.5 11 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0237699952209582 0.0428703462603594 0.749306388080151 0.8 11.5 11 5 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0671358839535862 0.105446316629087 0.749306388080151 0.8 11.5 11 5 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0671358839535862 0.105446316629087 0.749306388080151 0.8 11.5 11 5 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0671358839535862 0.105446316629087 0.749306388080151 0.8 11.5 11 5 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0671358839535862 0.105446316629087 0.749306388080151 0.8 11.5 11 5 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0671358839535862 0.105446316629087 0.749306388080151 0.8 11.5 11 5 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0671358839535862 0.105446316629087 0.749306388080151 0.8 11.5 11 5 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0671358839535862 0.105446316629087 0.749306388080151 0.8 11.5 11 5 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0671358839535862 0.105446316629087 0.749306388080151 0.8 11.5 11 5 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.92370828103908e-30 2.77362458927907e-28 0.748805514826086 0.799465240641711 11.5 11 5 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.84755217478644e-18 6.25968272552645e-17 0.747626328914052 0.798206278026906 11.5 11 5 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 7.84645603226138e-06 3.18105610652648e-05 0.746131361012014 0.796610169491525 11.5 11 5 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.6041929291692e-68 1.14138326910388e-65 0.745915861437254 0.796380090497738 11.5 11 5 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 4.88676081588362e-05 0.000171179446611328 0.745483396304232 0.795918367346939 11.5 11 5 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 5.36420182015351e-08 2.99127295745251e-07 0.745048965420604 0.795454545454545 11.5 11 5 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000122711374379882 0.000400500655372873 0.745048965420604 0.795454545454545 11.5 11 5 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.0209566594894e-07 3.65827606617097e-06 0.744174152545355 0.794520547945205 11.5 11 5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000787642732044862 0.00213488687180922 0.743796782285444 0.794117647058823 11.5 11 5 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000787642732044862 0.00213488687180922 0.743796782285444 0.794117647058823 11.5 11 5 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000787642732044862 0.00213488687180922 0.743796782285444 0.794117647058823 11.5 11 5 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.30761574040764e-13 7.37499092099296e-12 0.743263594627891 0.793548387096774 11.5 11 5 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.38524567598655e-08 1.95028526191452e-07 0.743197912090367 0.793478260869565 11.5 11 5 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.45273031307343e-09 1.07110633963912e-08 0.742555880079429 0.792792792792793 11.5 11 5 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.93084588915271e-59 2.46564842506608e-56 0.742350598946244 0.792573623559539 11.5 11 5 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 3.04001885027239e-05 0.000112362255167211 0.742237459890715 0.792452830188679 11.5 11 5 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 7.6015412425747e-05 0.00025877974134411 0.741501113204316 0.791666666666667 11.5 11 5 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 5.30824051955926e-15 8.03577261631152e-14 0.741292416015122 0.79144385026738 11.5 11 5 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000190919812223494 0.000603875238399696 0.740593523102475 0.790697674418605 11.5 11 5 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000190919812223494 0.000603875238399696 0.740593523102475 0.790697674418605 11.5 11 5 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 5.48833995247785e-09 3.73679796764401e-08 0.740386073936339 0.79047619047619 11.5 11 5 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 3.16116722877661e-07 1.50446186172211e-06 0.740055691931013 0.790123456790123 11.5 11 5 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 7.78362475166111e-07 3.56144630920057e-06 0.739447093500149 0.789473684210526 11.5 11 5 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0138620046791098 0.0265887555187931 0.739447093500149 0.789473684210526 11.5 11 5 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0138620046791098 0.0265887555187931 0.739447093500149 0.789473684210526 11.5 11 5 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.59755984098043e-114 5.11932765371515e-111 0.738906073461866 0.788896061975468 11.5 11 5 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 4.70705875765469e-05 0.000168719007862535 0.738499084405918 0.788461538461538 11.5 11 5 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0012261372033713 0.00318974998244489 0.737953260988027 0.787878787878788 11.5 11 5 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0012261372033713 0.00318974998244489 0.737953260988027 0.787878787878788 11.5 11 5 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0012261372033713 0.00318974998244489 0.737953260988027 0.787878787878788 11.5 11 5 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 5.60910729731668e-10 4.4098119801556e-09 0.737022676800148 0.786885245901639 11.5 11 5 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0376213101065407 0.0628346529126848 0.735925916864434 0.785714285714286 11.5 11 5 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0376213101065407 0.0628346529126848 0.735925916864434 0.785714285714286 11.5 11 5 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0376213101065407 0.0628346529126848 0.735925916864434 0.785714285714286 11.5 11 5 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0376213101065407 0.0628346529126848 0.735925916864434 0.785714285714286 11.5 11 5 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0376213101065407 0.0628346529126848 0.735925916864434 0.785714285714286 11.5 11 5 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0376213101065407 0.0628346529126848 0.735925916864434 0.785714285714286 11.5 11 5 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000295431289571154 0.000886917141476272 0.735925916864434 0.785714285714286 11.5 11 5 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.000181210014544225 0.000586049660673708 0.733017118774061 0.782608695652174 11.5 11 5 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000181210014544225 0.000586049660673708 0.733017118774061 0.782608695652174 11.5 11 5 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00817458174748675 0.0167614262632185 0.733017118774061 0.782608695652174 11.5 11 5 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00817458174748675 0.0167614262632185 0.733017118774061 0.782608695652174 11.5 11 5 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 8.24776227184161e-10 6.24285410256947e-09 0.732688706086438 0.782258064516129 11.5 11 5 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 8.24776227184161e-10 6.24285410256947e-09 0.732688706086438 0.782258064516129 11.5 11 5 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 8.24776227184161e-10 6.24285410256947e-09 0.732688706086438 0.782258064516129 11.5 11 5 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00189551059539956 0.00463455597466251 0.731744519609522 0.78125 11.5 11 5 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 7.86980494660446e-10 6.05336888595576e-09 0.730131224605659 0.779527559055118 11.5 11 5 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.1313525561333e-07 5.87560104882367e-07 0.729587798920147 0.778947368421053 11.5 11 5 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.1313525561333e-07 5.87560104882367e-07 0.729587798920147 0.778947368421053 11.5 11 5 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.1313525561333e-07 5.87560104882367e-07 0.729587798920147 0.778947368421053 11.5 11 5 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.8952538701478e-08 1.70245713108277e-07 0.729492998010724 0.778846153846154 11.5 11 5 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00486067443505843 0.0105922507214214 0.728492321744591 0.777777777777778 11.5 11 5 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00486067443505843 0.0105922507214214 0.728492321744591 0.777777777777778 11.5 11 5 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.00486067443505843 0.0105922507214214 0.728492321744591 0.777777777777778 11.5 11 5 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0216126451756579 0.0391780816368932 0.728492321744591 0.777777777777778 11.5 11 5 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.0216126451756579 0.0391780816368932 0.728492321744591 0.777777777777778 11.5 11 5 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0216126451756579 0.0391780816368932 0.728492321744591 0.777777777777778 11.5 11 5 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.106993710809822 0.159928624456278 0.728492321744591 0.777777777777778 11.5 11 5 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.106993710809822 0.159928624456278 0.728492321744591 0.777777777777778 11.5 11 5 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000277579961239604 0.000838633301154896 0.728492321744591 0.777777777777778 11.5 11 5 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.325641873897e-37 2.69484055222204e-35 0.725029386014507 0.774080560420315 11.5 11 5 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.12226940771338e-32 1.33082447264679e-30 0.724707946047217 0.773737373737374 11.5 11 5 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.000104027784412107 0.000345061858318015 0.724565139417127 0.773584905660377 11.5 11 5 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.012613883898618 0.0245212524422588 0.723761852122873 0.772727272727273 11.5 11 5 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 2.57817999610874e-08 1.53504189726474e-07 0.723761852122873 0.772727272727273 11.5 11 5 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 9.84881894888078e-06 3.97021795021455e-05 0.722545445648717 0.771428571428571 11.5 11 5 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000257766206367616 0.000782092348957607 0.721987926014729 0.770833333333333 11.5 11 5 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000257766206367616 0.000782092348957607 0.721987926014729 0.770833333333333 11.5 11 5 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0587013636584716 0.0933318888111789 0.720486911615529 0.769230769230769 11.5 11 5 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.0587013636584716 0.0933318888111789 0.720486911615529 0.769230769230769 11.5 11 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0587013636584716 0.0933318888111789 0.720486911615529 0.769230769230769 11.5 11 5 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0587013636584716 0.0933318888111789 0.720486911615529 0.769230769230769 11.5 11 5 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 8.70449532991321e-10 6.55370203940026e-09 0.717421009863974 0.765957446808511 11.5 11 5 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 4.77593623052257e-33 6.17832477821238e-31 0.717383690835163 0.765917602996255 11.5 11 5 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 3.62459772150598e-05 0.000130247539335935 0.717109629217332 0.765625 11.5 11 5 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00265124423518221 0.00611462001080111 0.716248753311909 0.764705882352941 11.5 11 5 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00265124423518221 0.00611462001080111 0.716248753311909 0.764705882352941 11.5 11 5 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0332896746592787 0.0579818935619996 0.716248753311909 0.764705882352941 11.5 11 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0332896746592787 0.0579818935619996 0.716248753311909 0.764705882352941 11.5 11 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0332896746592787 0.0579818935619996 0.716248753311909 0.764705882352941 11.5 11 5 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.2028605929552e-09 9.00879275671185e-09 0.713937030600843 0.762237762237762 11.5 11 5 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000963746473393203 0.00256338547969818 0.713625131504905 0.761904761904762 11.5 11 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.98048783493593e-06 8.51430268614448e-06 0.713118295474007 0.761363636363636 11.5 11 5 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000584211609815821 0.00165604207324285 0.712655532141448 0.760869565217391 11.5 11 5 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0112924298679873 0.0220125037015698 0.711841068676143 0.76 11.5 11 5 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0112924298679873 0.0220125037015698 0.711841068676143 0.76 11.5 11 5 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0112924298679873 0.0220125037015698 0.711841068676143 0.76 11.5 11 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.94354014094441e-06 1.25408910795326e-05 0.710549161110488 0.758620689655172 11.5 11 5 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00668565313339842 0.0139907123659205 0.710549161110488 0.758620689655172 11.5 11 5 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00398730244548788 0.00896355668235269 0.709570443257718 0.757575757575758 11.5 11 5 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 2.05803502774918e-15 3.75459467241933e-14 0.708902612252299 0.756862745098039 11.5 11 5 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.25140648167922e-10 1.84123645024685e-09 0.708185915563557 0.75609756097561 11.5 11 5 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.36005523125122e-06 1.80885090206136e-05 0.707920279436189 0.755813953488372 11.5 11 5 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0100030606542115 0.0196335935323351 0.702474738825141 0.75 11.5 11 5 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0100030606542115 0.0196335935323351 0.702474738825141 0.75 11.5 11 5 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0290664273401363 0.0511267318974215 0.702474738825141 0.75 11.5 11 5 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0901087948108031 0.135544201919422 0.702474738825141 0.75 11.5 11 5 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0901087948108031 0.135544201919422 0.702474738825141 0.75 11.5 11 5 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0901087948108031 0.135544201919422 0.702474738825141 0.75 11.5 11 5 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00594827509452454 0.0125398451251977 0.702474738825141 0.75 11.5 11 5 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0505860084903345 0.0811543292917091 0.702474738825141 0.75 11.5 11 5 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0505860084903345 0.0811543292917091 0.702474738825141 0.75 11.5 11 5 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0505860084903345 0.0811543292917091 0.702474738825141 0.75 11.5 11 5 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.167035001584539 0.22702082832359 0.702474738825141 0.75 11.5 11 5 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.167035001584539 0.22702082832359 0.702474738825141 0.75 11.5 11 5 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.167035001584539 0.22702082832359 0.702474738825141 0.75 11.5 11 5 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.167035001584539 0.22702082832359 0.702474738825141 0.75 11.5 11 5 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.167035001584539 0.22702082832359 0.702474738825141 0.75 11.5 11 5 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.167035001584539 0.22702082832359 0.702474738825141 0.75 11.5 11 5 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.167035001584539 0.22702082832359 0.702474738825141 0.75 11.5 11 5 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 6.55805668522967e-11 5.62175582113362e-10 0.697596442027745 0.744791666666667 11.5 11 5 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0031572680355476 0.00717698468783424 0.696470681228345 0.743589743589744 11.5 11 5 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0031572680355476 0.00717698468783424 0.696470681228345 0.743589743589744 11.5 11 5 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.8028357546853e-25 4.02025604642187e-23 0.694859836507253 0.741869918699187 11.5 11 5 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 2.94530514783493e-05 0.000109716471868301 0.693802211185325 0.740740740740741 11.5 11 5 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0148230374498971 0.027990682014124 0.693802211185325 0.740740740740741 11.5 11 5 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.19706070580407e-07 6.1655581686702e-07 0.693537401181056 0.740458015267176 11.5 11 5 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.19706070580407e-07 6.1655581686702e-07 0.693537401181056 0.740458015267176 11.5 11 5 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.03383713549299e-16 2.77575517699345e-15 0.692418863218238 0.739263803680982 11.5 11 5 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.87925639146834e-31 2.05706295773804e-29 0.691913947002472 0.738724727838258 11.5 11 5 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00462177693984521 0.0101650519094277 0.690150620600139 0.736842105263158 11.5 11 5 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0433144385659923 0.0702810103528017 0.690150620600139 0.736842105263158 11.5 11 5 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0433144385659923 0.0702810103528017 0.690150620600139 0.736842105263158 11.5 11 5 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00148782668306367 0.00368204759999932 0.688138519665444 0.73469387755102 11.5 11 5 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 6.15542804303744e-05 0.000212086540078506 0.687654596655835 0.734177215189873 11.5 11 5 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0128930565024065 0.0248939204924348 0.686864189073471 0.733333333333333 11.5 11 5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0128930565024065 0.0248939204924348 0.686864189073471 0.733333333333333 11.5 11 5 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0128930565024065 0.0248939204924348 0.686864189073471 0.733333333333333 11.5 11 5 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0128930565024065 0.0248939204924348 0.686864189073471 0.733333333333333 11.5 11 5 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0128930565024065 0.0248939204924348 0.686864189073471 0.733333333333333 11.5 11 5 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00404853023477417 0.00908684309792374 0.685341208609894 0.731707317073171 11.5 11 5 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00671250211282948 0.0140262709347377 0.68348893507311 0.72972972972973 11.5 11 5 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.35921649290666e-20 1.0173227483049e-18 0.682524036227716 0.728699551569507 11.5 11 5 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00023306328849921 0.000717855107217265 0.682404032001566 0.728571428571429 11.5 11 5 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 7.80986384347639e-05 0.000264605624982545 0.682238840998903 0.728395061728395 11.5 11 5 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0111775354919557 0.021878449800623 0.68118762552741 0.727272727272727 11.5 11 5 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0111775354919557 0.021878449800623 0.68118762552741 0.727272727272727 11.5 11 5 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.135731994532569 0.190560918244129 0.68118762552741 0.727272727272727 11.5 11 5 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.30345123308236e-08 8.70803335528734e-08 0.680692576380951 0.726744186046512 11.5 11 5 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 7.44895685453921e-13 7.41249342937713e-12 0.679650649838043 0.725631768953069 11.5 11 5 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00100507500847371 0.00265840471572136 0.678251471969102 0.724137931034483 11.5 11 5 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00100507500847371 0.00265840471572136 0.678251471969102 0.724137931034483 11.5 11 5 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00100507500847371 0.00265840471572136 0.678251471969102 0.724137931034483 11.5 11 5 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.21014397521893e-07 6.19437006020336e-07 0.676792866653039 0.72258064516129 11.5 11 5 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.063649951316693 0.100861782543045 0.676457155905692 0.722222222222222 11.5 11 5 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.063649951316693 0.100861782543045 0.676457155905692 0.722222222222222 11.5 11 5 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00268104674869132 0.00617334874334588 0.674375749272136 0.72 11.5 11 5 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0315304566475002 0.0553923948264108 0.674375749272136 0.72 11.5 11 5 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.50294119941514e-07 7.45186525006184e-07 0.674137116664467 0.719745222929936 11.5 11 5 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.7479530598397e-40 4.14556200691981e-38 0.674113229516552 0.71971971971972 11.5 11 5 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0014295554069378 0.00354400234158971 0.673718462966802 0.719298245614035 11.5 11 5 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000121231536045548 0.000396580404121413 0.672171906954253 0.717647058823529 11.5 11 5 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000121231536045548 0.000396580404121413 0.672171906954253 0.717647058823529 11.5 11 5 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00108191604491709 0.00284052865667347 0.669023560785849 0.714285714285714 11.5 11 5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0138040734823453 0.0265887555187931 0.669023560785849 0.714285714285714 11.5 11 5 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.111401497538299 0.165129511455207 0.669023560785849 0.714285714285714 11.5 11 5 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.111401497538299 0.165129511455207 0.669023560785849 0.714285714285714 11.5 11 5 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.111401497538299 0.165129511455207 0.669023560785849 0.714285714285714 11.5 11 5 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.111401497538299 0.165129511455207 0.669023560785849 0.714285714285714 11.5 11 5 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.111401497538299 0.165129511455207 0.669023560785849 0.714285714285714 11.5 11 5 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.111401497538299 0.165129511455207 0.669023560785849 0.714285714285714 11.5 11 5 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.111401497538299 0.165129511455207 0.669023560785849 0.714285714285714 11.5 11 5 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.111401497538299 0.165129511455207 0.669023560785849 0.714285714285714 11.5 11 5 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_225157.1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_216831.1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.254247787870313 0.330104563995854 0.669023560785849 0.714285714285714 11.5 11 5 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0118442820828818 0.0230566530833664 0.665502384150134 0.710526315789474 11.5 11 5 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0229041900214525 0.041413802287836 0.664707279748521 0.709677419354839 11.5 11 5 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0451859206596424 0.0729847503957674 0.663448364445967 0.708333333333333 11.5 11 5 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0920972096848684 0.138388943380747 0.661152695364839 0.705882352941177 11.5 11 5 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.68468824363753e-05 6.49677878237455e-05 0.660249481300133 0.704918032786885 11.5 11 5 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000250190412289226 0.000762357508966956 0.659900512229678 0.704545454545455 11.5 11 5 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0166547940255368 0.0311429328493283 0.658174530070402 0.702702702702703 11.5 11 5 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000188138841335341 0.000602976511757184 0.657635925708643 0.702127659574468 11.5 11 5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 7.72903621721321e-05 0.000262492089190797 0.656518447500132 0.700934579439252 11.5 11 5 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00136149695404731 0.00338116957348921 0.655643089570132 0.7 11.5 11 5 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0322870528155378 0.0564428454011183 0.655643089570132 0.7 11.5 11 5 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0322870528155378 0.0564428454011183 0.655643089570132 0.7 11.5 11 5 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.199995306807705 0.269501251503186 0.655643089570132 0.7 11.5 11 5 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.199995306807705 0.269501251503186 0.655643089570132 0.7 11.5 11 5 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.199995306807705 0.269501251503186 0.655643089570132 0.7 11.5 11 5 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.199995306807705 0.269501251503186 0.655643089570132 0.7 11.5 11 5 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.199995306807705 0.269501251503186 0.655643089570132 0.7 11.5 11 5 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.199995306807705 0.269501251503186 0.655643089570132 0.7 11.5 11 5 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.199995306807705 0.269501251503186 0.655643089570132 0.7 11.5 11 5 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.199995306807705 0.269501251503186 0.655643089570132 0.7 11.5 11 5 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000258846413082858 0.000783698820887037 0.654635957328089 0.698924731182796 11.5 11 5 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.027352970474827 0.0481723725070282 0.652804807797101 0.696969696969697 11.5 11 5 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0535601090904638 0.0856359946468876 0.648438220453977 0.692307692307692 11.5 11 5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.160775514903549 0.220408051741571 0.648438220453977 0.692307692307692 11.5 11 5 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.160775514903549 0.220408051741571 0.648438220453977 0.692307692307692 11.5 11 5 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.160775514903549 0.220408051741571 0.648438220453977 0.692307692307692 11.5 11 5 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.160775514903549 0.220408051741571 0.648438220453977 0.692307692307692 11.5 11 5 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.160775514903549 0.220408051741571 0.648438220453977 0.692307692307692 11.5 11 5 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.160775514903549 0.220408051741571 0.648438220453977 0.692307692307692 11.5 11 5 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00648053881072068 0.013581453207151 0.647128244251039 0.690909090909091 11.5 11 5 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00648053881072068 0.013581453207151 0.647128244251039 0.690909090909091 11.5 11 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0450101439785891 0.0727834487290139 0.645953782827716 0.689655172413793 11.5 11 5 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0450101439785891 0.0727834487290139 0.645953782827716 0.689655172413793 11.5 11 5 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00065714708190765 0.00185172336149423 0.645236056402352 0.688888888888889 11.5 11 5 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0142614816173113 0.0271311341463021 0.645236056402352 0.688888888888889 11.5 11 5 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00474986497070677 0.0103985505435627 0.64489484220013 0.688524590163934 11.5 11 5 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.130990544655321 0.190397900964782 0.643935177256379 0.6875 11.5 11 5 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.130990544655321 0.190397900964782 0.643935177256379 0.6875 11.5 11 5 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.130990544655321 0.190397900964782 0.643935177256379 0.6875 11.5 11 5 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.130990544655321 0.190397900964782 0.643935177256379 0.6875 11.5 11 5 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0320135126188602 0.056102498099308 0.642262618354415 0.685714285714286 11.5 11 5 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0320135126188602 0.056102498099308 0.642262618354415 0.685714285714286 11.5 11 5 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00883887748504064 0.017968175230304 0.641767045346425 0.685185185185185 11.5 11 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00471683328220509 0.0103421475509674 0.638613398931947 0.681818181818182 11.5 11 5 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.051991064683117 0.0832207930754504 0.634493312487224 0.67741935483871 11.5 11 5 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.051991064683117 0.0832207930754504 0.634493312487224 0.67741935483871 11.5 11 5 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0252992139851606 0.0447214677029609 0.624421990066792 0.666666666666667 11.5 11 5 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.226978393976101 0.297961489509217 0.624421990066792 0.666666666666667 11.5 11 5 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.226978393976101 0.297961489509217 0.624421990066792 0.666666666666667 11.5 11 5 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.226978393976101 0.297961489509217 0.624421990066792 0.666666666666667 11.5 11 5 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.226978393976101 0.297961489509217 0.624421990066792 0.666666666666667 11.5 11 5 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.02180759386985e-06 4.57242832099622e-06 0.624421990066792 0.666666666666667 11.5 11 5 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0590516790436398 0.0937840840168521 0.624421990066792 0.666666666666667 11.5 11 5 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.148991726421219 0.2058400259198 0.624421990066792 0.666666666666667 11.5 11 5 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.287117583133974 0.354045338647872 0.624421990066792 0.666666666666667 11.5 11 5 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0241016650390843 0.0434135055071101 0.618531216575596 0.660377358490566 11.5 11 5 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00253959134675766 0.00602306414406025 0.618177770166124 0.66 11.5 11 5 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0788555209006073 0.119373836427196 0.614665396471999 0.65625 11.5 11 5 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.019418804193145 0.0353362638962217 0.614185564000123 0.655737704918033 11.5 11 5 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0268427795857137 0.0473324353785262 0.613068862974669 0.654545454545455 11.5 11 5 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0268427795857137 0.0473324353785262 0.613068862974669 0.654545454545455 11.5 11 5 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.113197385475963 0.1676169402001 0.6124138748732 0.653846153846154 11.5 11 5 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0372759041617026 0.062699304517852 0.611678684147062 0.653061224489796 11.5 11 5 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0156380171963156 0.0292801295662593 0.610847598978384 0.652173913043478 11.5 11 5 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.165561029093623 0.226532061923294 0.608811440315122 0.65 11.5 11 5 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000101278645877283 0.000336727834306946 0.608573716207229 0.649746192893401 11.5 11 5 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.087166578194038 0.131675202516047 0.606056637417769 0.647058823529412 11.5 11 5 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.202294992101151 0.272342264673546 0.606056637417769 0.647058823529412 11.5 11 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0485019107952102 0.0782519490494152 0.604908802877205 0.645833333333333 11.5 11 5 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 2.74260703871214e-05 0.000103246820531412 0.602383566887964 0.643137254901961 11.5 11 5 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.249648746161 0.327118016378548 0.602121204707264 0.642857142857143 11.5 11 5 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.149733418557326 0.206463812603755 0.599445110464121 0.64 11.5 11 5 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 9.40501634710781e-05 0.000315644770328642 0.598962724377374 0.639484978540773 11.5 11 5 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.312456103289194 0.38263772373539 0.596039172336484 0.636363636363636 11.5 11 5 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.312456103289194 0.38263772373539 0.596039172336484 0.636363636363636 11.5 11 5 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.312456103289194 0.38263772373539 0.596039172336484 0.636363636363636 11.5 11 5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.312456103289194 0.38263772373539 0.596039172336484 0.636363636363636 11.5 11 5 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.312456103289194 0.38263772373539 0.596039172336484 0.636363636363636 11.5 11 5 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0576485715443729 0.0920694919277695 0.594401702082812 0.634615384615385 11.5 11 5 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.087315742361628 0.131760658940187 0.593962380795241 0.634146341463415 11.5 11 5 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.219760007812089 0.289554158441299 0.591557674800119 0.631578947368421 11.5 11 5 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0799133758146168 0.120846688399787 0.590486012345771 0.630434782608696 11.5 11 5 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.269094800324093 0.335308144361808 0.585395615687618 0.625 11.5 11 5 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 48%5605118 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS 0.399602431679938 0.470723725397808 0.585395615687618 0.625 11.5 11 5 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.399602431679938 0.470723725397808 0.585395615687618 0.625 11.5 11 5 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.399602431679938 0.470723725397808 0.585395615687618 0.625 11.5 11 5 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.399602431679938 0.470723725397808 0.585395615687618 0.625 11.5 11 5 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.399602431679938 0.470723725397808 0.585395615687618 0.625 11.5 11 5 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.101121571092498 0.15162907867716 0.582793857395673 0.622222222222222 11.5 11 5 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00466332035917603 0.0102405939368943 0.581759618074651 0.62111801242236 11.5 11 5 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00605059627403552 0.0127178707502992 0.578168509321104 0.617283950617284 11.5 11 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.208191071487506 0.275105264237412 0.576389529292424 0.615384615384615 11.5 11 5 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.332903000492184 0.405191588966613 0.576389529292424 0.615384615384615 11.5 11 5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.286057266741044 0.354045338647872 0.572386824227893 0.611111111111111 11.5 11 5 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0059645503288019 0.0125555549081141 0.572105553061196 0.610810810810811 11.5 11 5 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0178026914835044 0.0332021362791963 0.563129033986616 0.601226993865031 11.5 11 5 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.262957962991116 0.332516051862913 0.561979791060113 0.6 11.5 11 5 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.301058475889789 0.370593608296859 0.561979791060113 0.6 11.5 11 5 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.349952404605834 0.419530136271358 0.561979791060113 0.6 11.5 11 5 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.349952404605834 0.419530136271358 0.561979791060113 0.6 11.5 11 5 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.417800997623376 0.490536979882891 0.561979791060113 0.6 11.5 11 5 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.417800997623376 0.490536979882891 0.561979791060113 0.6 11.5 11 5 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.417800997623376 0.490536979882891 0.561979791060113 0.6 11.5 11 5 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.417800997623376 0.490536979882891 0.561979791060113 0.6 11.5 11 5 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0220089854021008 0.0398457840040577 0.561979791060113 0.6 11.5 11 5 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.206068251677932 0.275105264237412 0.561979791060113 0.6 11.5 11 5 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.242753985073297 0.318376885492444 0.556125834903237 0.59375 11.5 11 5 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.36452309778544 0.436262715011506 0.550960579470699 0.588235294117647 11.5 11 5 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0957044111582504 0.143657570757585 0.550392578873307 0.587628865979381 11.5 11 5 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0447979153222735 0.0726052773389467 0.548272966887915 0.585365853658537 11.5 11 5 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0487475520242784 0.0784703241295794 0.547841934681242 0.584905660377358 11.5 11 5 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0487475520242784 0.0784703241295794 0.547841934681242 0.584905660377358 11.5 11 5 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.377215997768356 0.447688377668366 0.542261201900109 0.578947368421053 11.5 11 5 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.377215997768356 0.447688377668366 0.542261201900109 0.578947368421053 11.5 11 5 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.388443352011007 0.460629074926385 0.535218848628679 0.571428571428571 11.5 11 5 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.443908672933764 0.519475363145351 0.535218848628679 0.571428571428571 11.5 11 5 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.443908672933764 0.519475363145351 0.535218848628679 0.571428571428571 11.5 11 5 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.443908672933764 0.519475363145351 0.535218848628679 0.571428571428571 11.5 11 5 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.357114250470518 0.427755537390192 0.530758691556773 0.566666666666667 11.5 11 5 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.39849896301639 0.470723725397808 0.529401252447933 0.565217391304348 11.5 11 5 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.106562872809774 0.159619966324535 0.528744427072687 0.564516129032258 11.5 11 5 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.146283269309356 0.202294550269401 0.528528613020821 0.564285714285714 11.5 11 5 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.149273997488589 0.206029969375618 0.527680554986022 0.563380281690141 11.5 11 5 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.250273280203476 0.327634662124698 0.527680554986022 0.563380281690141 11.5 11 5 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.453912181539501 0.530309551995657 0.526856054118856 0.5625 11.5 11 5 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.453912181539501 0.530309551995657 0.526856054118856 0.5625 11.5 11 5 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.161952145287583 0.221807413613311 0.526428758049011 0.562043795620438 11.5 11 5 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.182284272842561 0.247510038411226 0.523412550497164 0.558823529411765 11.5 11 5 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.30438298874187 0.374362137406811 0.522057729400105 0.557377049180328 11.5 11 5 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.540208492362393 0.596366706463681 0.520351658388994 0.555555555555556 11.5 11 5 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.540208492362393 0.596366706463681 0.520351658388994 0.555555555555556 11.5 11 5 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.540208492362393 0.596366706463681 0.520351658388994 0.555555555555556 11.5 11 5 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.540208492362393 0.596366706463681 0.520351658388994 0.555555555555556 11.5 11 5 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.207616103894667 0.275105264237412 0.519592020931491 0.554744525547445 11.5 11 5 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.291530640216303 0.359175845045713 0.513346924526065 0.548076923076923 11.5 11 5 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.477201518460437 0.557061329589173 0.510890719145557 0.545454545454545 11.5 11 5 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.544214870824394 0.599858839026424 0.510890719145557 0.545454545454545 11.5 11 5 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.544214870824394 0.599858839026424 0.510890719145557 0.545454545454545 11.5 11 5 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.443358022113621 0.519475363145351 0.508457906197245 0.542857142857143 11.5 11 5 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.547883774802087 0.602968763761307 0.504340838130871 0.538461538461538 11.5 11 5 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.547883774802087 0.602968763761307 0.504340838130871 0.538461538461538 11.5 11 5 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.494527825196042 0.576814012503253 0.501767670589387 0.535714285714286 11.5 11 5 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.390972834201418 0.463242583737401 0.501429779902121 0.535353535353535 11.5 11 5 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.551287265308541 0.606245578465265 0.499537592053434 0.533333333333333 11.5 11 5 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.560336880923096 0.615721530157194 0.490617277909622 0.523809523809524 11.5 11 5 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.563058851672124 0.618235143464068 0.488678079182707 0.521739130434783 11.5 11 5 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.392957536613329 0.465206800832586 0.486592258113025 0.519512195121951 11.5 11 5 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.568168135391408 0.623364114619872 0.485661547829727 0.518518518518518 11.5 11 5 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.57516233163013 0.630551616263232 0.482507901415249 0.515151515151515 11.5 11 5 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.656304845321264 0.717849189002428 0.468316492550094 0.5 11.5 11 5 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.66261598710141 0.722530689383377 0.468316492550094 0.5 11.5 11 5 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.66261598710141 0.722530689383377 0.468316492550094 0.5 11.5 11 5 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.66261598710141 0.722530689383377 0.468316492550094 0.5 11.5 11 5 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.66261598710141 0.722530689383377 0.468316492550094 0.5 11.5 11 5 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.651858876670411 0.713534755001534 0.468316492550094 0.5 11.5 11 5 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.651858876670411 0.713534755001534 0.468316492550094 0.5 11.5 11 5 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.697035504065517 0.75313707083161 0.458759013110296 0.489795918367347 11.5 11 5 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.698687091209518 0.754348809401475 0.457425411327999 0.488372093023256 11.5 11 5 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.706174689351434 0.760260031762911 0.453209508919446 0.483870967741935 11.5 11 5 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.706174689351434 0.760260031762911 0.453209508919446 0.483870967741935 11.5 11 5 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.947266520909504 0.978200478413806 0.446590469699832 0.47680412371134 11.5 11 5 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.739859036612047 0.789812009826663 0.437095393046755 0.466666666666667 11.5 11 5 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.942236337990529 0.977586095614292 0.435944384770134 0.465437788018433 11.5 11 5 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.761283583998923 0.810527900896856 0.425742265954631 0.454545454545455 11.5 11 5 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.761283583998923 0.810527900896856 0.425742265954631 0.454545454545455 11.5 11 5 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.985041105273016 1 0.424829961099014 0.453571428571429 11.5 11 5 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.801216613695506 0.846422599323464 0.416281326711195 0.444444444444444 11.5 11 5 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.944601465540183 0.977586095614292 0.416281326711195 0.444444444444444 11.5 11 5 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.862857322875501 0.908842317136815 0.405874293543415 0.433333333333333 11.5 11 5 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.918299336254954 0.960132222991035 0.398567227702208 0.425531914893617 11.5 11 5 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.995740137610532 1 0.393811596008034 0.420454545454545 11.5 11 5 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.896487886543992 0.938706594961075 0.392781574396853 0.419354838709677 11.5 11 5 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.969325004312633 0.995201645841902 0.391251753269699 0.417721518987342 11.5 11 5 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.881500981940639 0.925738669595224 0.390263743791745 0.416666666666667 11.5 11 5 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.946906111705336 0.978200478413806 0.388791050418946 0.415094339622642 11.5 11 5 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_220332.1 ANDROGEN BIOSYNTHESIS 0.877212188238919 0.921915025010326 0.374653194040075 0.4 11.5 11 5 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.989880254611944 1 0.374653194040075 0.4 11.5 11 5 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.965642122759204 0.992136274863789 0.370750556602158 0.395833333333333 11.5 11 5 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.93322999653364 0.97075020838258 0.367962958432217 0.392857142857143 11.5 11 5 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.976301479917168 0.999479860375633 0.358710504931987 0.382978723404255 11.5 11 5 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.950926875191707 0.980557205360724 0.340593812763705 0.363636363636364 11.5 11 5 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.950926875191707 0.980557205360724 0.340593812763705 0.363636363636364 11.5 11 5 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.928658441787969 0.966701508898522 0.334511780392924 0.357142857142857 11.5 11 5 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.928658441787969 0.966701508898522 0.334511780392924 0.357142857142857 11.5 11 5 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.928658441787969 0.966701508898522 0.334511780392924 0.357142857142857 11.5 11 5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.996571326675229 1 0.312210995033396 0.333333333333333 11.5 11 5 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.990863366307182 1 0.302139672612964 0.32258064516129 11.5 11 5 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.985554218862013 1 0.29972255523206 0.32 11.5 11 5 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.996128970203222 1 0.29577883740006 0.315789473684211 11.5 11 5 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.287831798947665 0.307304785894207 11.5 11 5 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.988366407336621 1 0.285062212856579 0.304347826086957 11.5 11 5 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.254059580045259 0.27124773960217 11.5 11 5 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.99612494922287 1 0.234158246275047 0.25 11.5 11 5 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.999997125260935 1 0.178406282876226 0.19047619047619 11.5 11 5 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.042299554165815 0.0451612903225806 11.5 11 5 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.90317579489151e-06 9.02739718710206e-06 1.16960859554873 1 11.4 11 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 8.96821890623831e-06 3.76453554677791e-05 1.16960859554873 1 11.4 11 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 8.96821890623831e-06 3.76453554677791e-05 1.16960859554873 1 11.4 11 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 8.96821890623831e-06 3.76453554677791e-05 1.16960859554873 1 11.4 11 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 8.96821890623831e-06 3.76453554677791e-05 1.16960859554873 1 11.4 11 4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.000199058569154647 0.000661823233427718 1.16960859554873 1 11.4 11 4 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 8.76683361559869e-07 4.2723302174647e-06 1.16960859554873 1 11.4 11 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 8.76683361559869e-07 4.2723302174647e-06 1.16960859554873 1 11.4 11 4 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 4.13142668714349e-06 1.86619077436704e-05 1.16960859554873 1 11.4 11 4 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 4.13142668714349e-06 1.86619077436704e-05 1.16960859554873 1 11.4 11 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 1.9466925048684e-05 7.80322094204994e-05 1.16960859554873 1 11.4 11 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 9.17138012868624e-05 0.000325458202571584 1.16960859554873 1 11.4 11 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 9.17138012868624e-05 0.000325458202571584 1.16960859554873 1 11.4 11 4 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 9.17138012868624e-05 0.000325458202571584 1.16960859554873 1 11.4 11 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 9.17138012868624e-05 0.000325458202571584 1.16960859554873 1 11.4 11 4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 9.17138012868624e-05 0.000325458202571584 1.16960859554873 1 11.4 11 4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.000432028178312473 0.00131643704012559 1.16960859554873 1 11.4 11 4 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000432028178312473 0.00131643704012559 1.16960859554873 1 11.4 11 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000432028178312473 0.00131643704012559 1.16960859554873 1 11.4 11 4 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.000432028178312473 0.00131643704012559 1.16960859554873 1 11.4 11 4 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000432028178312473 0.00131643704012559 1.16960859554873 1 11.4 11 4 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.000432028178312473 0.00131643704012559 1.16960859554873 1 11.4 11 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.000937623066965351 0.0026525598892479 1.16960859554873 1 11.4 11 4 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.000937623066965351 0.0026525598892479 1.16960859554873 1 11.4 11 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.000937623066965351 0.0026525598892479 1.16960859554873 1 11.4 11 4 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.000937623066965351 0.0026525598892479 1.16960859554873 1 11.4 11 4 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.000937623066965351 0.0026525598892479 1.16960859554873 1 11.4 11 4 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00203483644351144 0.00513399336722834 1.16960859554873 1 11.4 11 4 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0044158645885583 0.0101188008204806 1.16960859554873 1 11.4 11 4 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0044158645885583 0.0101188008204806 1.16960859554873 1 11.4 11 4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0044158645885583 0.0101188008204806 1.16960859554873 1 11.4 11 4 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0044158645885583 0.0101188008204806 1.16960859554873 1 11.4 11 4 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0044158645885583 0.0101188008204806 1.16960859554873 1 11.4 11 4 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0044158645885583 0.0101188008204806 1.16960859554873 1 11.4 11 4 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00958268042960463 0.0197339424765954 1.16960859554873 1 11.4 11 4 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00958268042960463 0.0197339424765954 1.16960859554873 1 11.4 11 4 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00958268042960463 0.0197339424765954 1.16960859554873 1 11.4 11 4 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00958268042960463 0.0197339424765954 1.16960859554873 1 11.4 11 4 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00958268042960463 0.0197339424765954 1.16960859554873 1 11.4 11 4 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00958268042960463 0.0197339424765954 1.16960859554873 1 11.4 11 4 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00958268042960463 0.0197339424765954 1.16960859554873 1 11.4 11 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.00958268042960463 0.0197339424765954 1.16960859554873 1 11.4 11 4 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_199058.2 GRB7 EVENTS IN ERBB2 SIGNALING 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%REACT_209347.1 NGF-INDEPENDANT TRKA ACTIVATION 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0207942510070859 0.0376426557871145 1.16960859554873 1 11.4 11 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.667390026925e-08 1.68697600369523e-07 1.12628975867656 0.962962962962963 11.4 11 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 5.58408370718561e-08 3.25661930955948e-07 1.12462364956609 0.961538461538462 11.4 11 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 5.58408370718561e-08 3.25661930955948e-07 1.12462364956609 0.961538461538462 11.4 11 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.1673462832062e-07 6.244863763167e-07 1.12282425172678 0.96 11.4 11 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 2.43658927581504e-07 1.26082419617629e-06 1.12087490406754 0.958333333333333 11.4 11 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 1.05616455057299e-06 5.11198012063048e-06 1.11644456847834 0.954545454545455 11.4 11 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 2.19265133595642e-06 1.02975011586336e-05 1.11391294814165 0.952380952380952 11.4 11 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.62936613954503e-10 1.43122717072382e-09 1.10805024841459 0.947368421052632 11.4 11 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 1.93535471615294e-05 7.77968859063739e-05 1.10463034024047 0.944444444444444 11.4 11 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 3.97834409631752e-05 0.000152182356157522 1.10080808992822 0.941176470588235 11.4 11 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 3.97834409631752e-05 0.000152182356157522 1.10080808992822 0.941176470588235 11.4 11 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 3.97834409631752e-05 0.000152182356157522 1.10080808992822 0.941176470588235 11.4 11 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 3.97834409631752e-05 0.000152182356157522 1.10080808992822 0.941176470588235 11.4 11 4 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 8.15201021926606e-05 0.000294424125431868 1.09650805832694 0.9375 11.4 11 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 8.15201021926606e-05 0.000294424125431868 1.09650805832694 0.9375 11.4 11 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 8.15201021926606e-05 0.000294424125431868 1.09650805832694 0.9375 11.4 11 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 8.15201021926606e-05 0.000294424125431868 1.09650805832694 0.9375 11.4 11 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 8.15201021926606e-05 0.000294424125431868 1.09650805832694 0.9375 11.4 11 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 8.15201021926606e-05 0.000294424125431868 1.09650805832694 0.9375 11.4 11 4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 8.15201021926606e-05 0.000294424125431868 1.09650805832694 0.9375 11.4 11 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000166448811042924 0.000563944424081143 1.09163468917882 0.933333333333333 11.4 11 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000166448811042924 0.000563944424081143 1.09163468917882 0.933333333333333 11.4 11 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 2.08014083198241e-07 1.08030671675583e-06 1.08606512443811 0.928571428571429 11.4 11 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000338493728739694 0.00106096162113785 1.08606512443811 0.928571428571429 11.4 11 4 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000338493728739694 0.00106096162113785 1.08606512443811 0.928571428571429 11.4 11 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000338493728739694 0.00106096162113785 1.08606512443811 0.928571428571429 11.4 11 4 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000338493728739694 0.00106096162113785 1.08606512443811 0.928571428571429 11.4 11 4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.000338493728739694 0.00106096162113785 1.08606512443811 0.928571428571429 11.4 11 4 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000685224770124137 0.00200632684750339 1.07963870358345 0.923076923076923 11.4 11 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000685224770124137 0.00200632684750339 1.07963870358345 0.923076923076923 11.4 11 4 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.000685224770124137 0.00200632684750339 1.07963870358345 0.923076923076923 11.4 11 4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000685224770124137 0.00200632684750339 1.07963870358345 0.923076923076923 11.4 11 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000685224770124137 0.00200632684750339 1.07963870358345 0.923076923076923 11.4 11 4 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000685224770124137 0.00200632684750339 1.07963870358345 0.923076923076923 11.4 11 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.40386111936031e-12 4.03641197737477e-11 1.07787458805472 0.92156862745098 11.4 11 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.40386111936031e-12 4.03641197737477e-11 1.07787458805472 0.92156862745098 11.4 11 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 3.41270197016226e-06 1.57161000114592e-05 1.07214121258634 0.916666666666667 11.4 11 4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 3.41270197016226e-06 1.57161000114592e-05 1.07214121258634 0.916666666666667 11.4 11 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00137985101570028 0.00364290908226624 1.07214121258634 0.916666666666667 11.4 11 4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 6.81456092972543e-06 2.97457674938629e-05 1.06790350028363 0.91304347826087 11.4 11 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 6.81456092972543e-06 2.97457674938629e-05 1.06790350028363 0.91304347826087 11.4 11 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.15696395064807e-10 1.84901186853747e-09 1.06564338705551 0.911111111111111 11.4 11 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.27797112857659e-10 3.51881671443034e-09 1.06328054140794 0.909090909090909 11.4 11 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 1.35575191897908e-05 5.5919854513253e-05 1.06328054140794 0.909090909090909 11.4 11 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 1.35575191897908e-05 5.5919854513253e-05 1.06328054140794 0.909090909090909 11.4 11 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.00276172426989073 0.00658104427964385 1.06328054140794 0.909090909090909 11.4 11 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.6717950501235e-09 1.25871129964325e-08 1.05821730073457 0.904761904761905 11.4 11 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 2.68646827663559e-05 0.000105603435294266 1.05821730073457 0.904761904761905 11.4 11 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.68646827663559e-05 0.000105603435294266 1.05821730073457 0.904761904761905 11.4 11 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2.90542353733037e-07 1.49797742522504e-06 1.05642066694724 0.903225806451613 11.4 11 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.75376333049727e-15 5.02385284525335e-14 1.05589664875927 0.902777777777778 11.4 11 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 6.1927378673724e-32 6.7786661425161e-30 1.05264773599386 0.9 11.4 11 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 5.30002850567209e-05 0.000197951195894262 1.05264773599386 0.9 11.4 11 4 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 5.30002850567209e-05 0.000197951195894262 1.05264773599386 0.9 11.4 11 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 5.30002850567209e-05 0.000197951195894262 1.05264773599386 0.9 11.4 11 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 5.30002850567209e-05 0.000197951195894262 1.05264773599386 0.9 11.4 11 4 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00548797706484125 0.0119959928775255 1.05264773599386 0.9 11.4 11 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000104059335831244 0.000367435322302384 1.04649190128045 0.894736842105263 11.4 11 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.19053974632267e-06 1.02975011586336e-05 1.0442933888828 0.892857142857143 11.4 11 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.09445034743283e-09 8.70057454970343e-09 1.04247722646735 0.891304347826087 11.4 11 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 9.39028676637566e-08 5.36573002093383e-07 1.03965208493221 0.888888888888889 11.4 11 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 4.26372073291669e-06 1.90196696016942e-05 1.03965208493221 0.888888888888889 11.4 11 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.26372073291669e-06 1.90196696016942e-05 1.03965208493221 0.888888888888889 11.4 11 4 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 4.26372073291669e-06 1.90196696016942e-05 1.03965208493221 0.888888888888889 11.4 11 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000203222591376341 0.000669411452612345 1.03965208493221 0.888888888888889 11.4 11 4 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.000203222591376341 0.000669411452612345 1.03965208493221 0.888888888888889 11.4 11 4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000203222591376341 0.000669411452612345 1.03965208493221 0.888888888888889 11.4 11 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000203222591376341 0.000669411452612345 1.03965208493221 0.888888888888889 11.4 11 4 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0108125434558802 0.0216402944271695 1.03965208493221 0.888888888888889 11.4 11 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.20211938558502e-12 2.655606682786e-11 1.03755601218033 0.887096774193548 11.4 11 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 1.81881844464071e-07 9.51536267177843e-07 1.03593904177174 0.885714285714286 11.4 11 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 8.26463825336345e-06 3.55455772426194e-05 1.0346537576008 0.884615384615385 11.4 11 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.07657826915015e-16 6.15618932708473e-15 1.03360759606632 0.883720930232558 11.4 11 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 7.94296875457411e-09 5.30649978298542e-08 1.03360759606632 0.883720930232558 11.4 11 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.51097175359439e-07 1.77797608731844e-06 1.03200758430771 0.882352941176471 11.4 11 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0003945450614138 0.00121786902904954 1.03200758430771 0.882352941176471 11.4 11 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0003945450614138 0.00121786902904954 1.03200758430771 0.882352941176471 11.4 11 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 1.59484017114197e-05 6.46569106420236e-05 1.02925556408289 0.88 11.4 11 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 1.59484017114197e-05 6.46569106420236e-05 1.02925556408289 0.88 11.4 11 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 1.59484017114197e-05 6.46569106420236e-05 1.02925556408289 0.88 11.4 11 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.93567718468186e-08 1.84603827637745e-07 1.02697340096962 0.878048780487805 11.4 11 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.48103758956729e-09 1.83881067185117e-08 1.02340752110514 0.875 11.4 11 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 3.06275736466676e-05 0.000119079336883082 1.02340752110514 0.875 11.4 11 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 3.06275736466676e-05 0.000119079336883082 1.02340752110514 0.875 11.4 11 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 5.61758884203587e-08 3.26278731519063e-07 1.02340752110514 0.875 11.4 11 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000760949772994764 0.00219641283361369 1.02340752110514 0.875 11.4 11 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000760949772994764 0.00219641283361369 1.02340752110514 0.875 11.4 11 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000760949772994764 0.00219641283361369 1.02340752110514 0.875 11.4 11 4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000760949772994764 0.00219641283361369 1.02340752110514 0.875 11.4 11 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000760949772994764 0.00219641283361369 1.02340752110514 0.875 11.4 11 4 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0210830616038863 0.0376426557871145 1.02340752110514 0.875 11.4 11 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 4.31558644331551e-13 5.63401789801649e-12 1.02134835104256 0.873239436619718 11.4 11 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 9.52046303791822e-12 1.06674164590217e-10 1.02108686912985 0.873015873015873 11.4 11 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 9.52046303791822e-12 1.06674164590217e-10 1.02108686912985 0.873015873015873 11.4 11 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.73028034287057e-09 3.33227174648753e-08 1.02029685994677 0.872340425531915 11.4 11 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 5.85105742568935e-05 0.000215700899397823 1.01705095265107 0.869565217391304 11.4 11 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.85105742568935e-05 0.000215700899397823 1.01705095265107 0.869565217391304 11.4 11 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.1110252167752e-22 1.09299442260094e-20 1.01665977920775 0.869230769230769 11.4 11 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 6.1579320455777e-15 1.09534216260713e-13 1.01644556517926 0.869047619047619 11.4 11 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 6.1579320455777e-15 1.09534216260713e-13 1.01644556517926 0.869047619047619 11.4 11 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.54640390332241e-13 3.55248309257626e-12 1.0136607828089 0.866666666666667 11.4 11 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.54640390332241e-13 3.55248309257626e-12 1.0136607828089 0.866666666666667 11.4 11 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.54640390332241e-13 3.55248309257626e-12 1.0136607828089 0.866666666666667 11.4 11 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.54640390332241e-13 3.55248309257626e-12 1.0136607828089 0.866666666666667 11.4 11 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.54640390332241e-13 3.55248309257626e-12 1.0136607828089 0.866666666666667 11.4 11 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.70422309506293e-08 1.11756196510348e-07 1.0136607828089 0.866666666666667 11.4 11 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.69214830671302e-06 2.08653970014145e-05 1.0136607828089 0.866666666666667 11.4 11 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00145678569376871 0.0038106728717516 1.0136607828089 0.866666666666667 11.4 11 4 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00145678569376871 0.0038106728717516 1.0136607828089 0.866666666666667 11.4 11 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00145678569376871 0.0038106728717516 1.0136607828089 0.866666666666667 11.4 11 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00145678569376871 0.0038106728717516 1.0136607828089 0.866666666666667 11.4 11 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.58004057205e-12 6.56231217688195e-11 1.01249699316159 0.865671641791045 11.4 11 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 3.85598037557993e-07 1.93206340649657e-06 1.01155337993404 0.864864864864865 11.4 11 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.22803120088202e-10 1.10600531573108e-09 1.01101759954213 0.864406779661017 11.4 11 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.22803120088202e-10 1.10600531573108e-09 1.01101759954213 0.864406779661017 11.4 11 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000111143385417934 0.000387639797670882 1.01011651433754 0.863636363636364 11.4 11 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000111143385417934 0.000387639797670882 1.01011651433754 0.863636363636364 11.4 11 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.31305692769077e-10 1.94762130657039e-09 1.00828327202477 0.862068965517241 11.4 11 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.31305692769077e-10 1.94762130657039e-09 1.00828327202477 0.862068965517241 11.4 11 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.87467684034372e-06 3.76453554677791e-05 1.00828327202477 0.862068965517241 11.4 11 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 7.27351500626008e-07 3.58138818474329e-06 1.00716295727808 0.861111111111111 11.4 11 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 6.06194475892668e-08 3.50656398046856e-07 1.00640739616984 0.86046511627907 11.4 11 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.1046072108132e-15 2.91084455738368e-14 1.00611492090214 0.860215053763441 11.4 11 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.82815760017276e-26 2.23581570280324e-24 1.00457179985781 0.858895705521472 11.4 11 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.47231040727218e-27 2.51292693539165e-25 1.0044873820595 0.858823529411765 11.4 11 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.38666131507736e-14 3.85933983108533e-13 1.0044873820595 0.858823529411765 11.4 11 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.38666131507736e-14 3.85933983108533e-13 1.0044873820595 0.858823529411765 11.4 11 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.38666131507736e-14 3.85933983108533e-13 1.0044873820595 0.858823529411765 11.4 11 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.63169036679102e-27 4.39393026129575e-25 1.00351033345897 0.857988165680473 11.4 11 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.22738569216031e-19 9.05591382841179e-18 1.00252165332749 0.857142857142857 11.4 11 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 8.14102837788706e-10 6.58220646689392e-09 1.00252165332749 0.857142857142857 11.4 11 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.13738352306123e-07 6.20258806535829e-07 1.00252165332749 0.857142857142857 11.4 11 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0027656110184308 0.00658104427964385 1.00252165332749 0.857142857142857 11.4 11 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0027656110184308 0.00658104427964385 1.00252165332749 0.857142857142857 11.4 11 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0027656110184308 0.00658104427964385 1.00252165332749 0.857142857142857 11.4 11 4 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0405835754758826 0.0686687608824982 1.00252165332749 0.857142857142857 11.4 11 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 9.58127355693023e-09 6.31210753310727e-08 1.00252165332749 0.857142857142857 11.4 11 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 9.63978830202518e-13 1.22476953158766e-11 1.00032314092984 0.855263157894737 11.4 11 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.79653589837033e-12 2.18501759263332e-11 0.998066001534919 0.853333333333333 11.4 11 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.66248792083725e-32 3.15726692612617e-30 0.996952088586778 0.852380952380952 11.4 11 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.89217524422809e-13 3.90817912247197e-12 0.996333248060032 0.851851851851852 11.4 11 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.89217524422809e-13 3.90817912247197e-12 0.996333248060032 0.851851851851852 11.4 11 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 3.12699139959322e-05 0.000121245470343901 0.996333248060032 0.851851851851852 11.4 11 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.33466056543046e-08 2.06313999330763e-07 0.995411570679773 0.851063829787234 11.4 11 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.87058561252527e-11 3.99119081639381e-10 0.995040148451908 0.850746268656716 11.4 11 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 3.87058561252527e-11 3.99119081639381e-10 0.995040148451908 0.850746268656716 11.4 11 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 3.87058561252527e-11 3.99119081639381e-10 0.995040148451908 0.850746268656716 11.4 11 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.72001266010089e-17 1.93799476555323e-15 0.99471385228911 0.850467289719626 11.4 11 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 4.50168786936784e-10 3.68155278052324e-09 0.994167306216424 0.85 11.4 11 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000393393956886879 0.00121786902904954 0.994167306216423 0.85 11.4 11 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000393393956886879 0.00121786902904954 0.994167306216423 0.85 11.4 11 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000393393956886879 0.00121786902904954 0.994167306216423 0.85 11.4 11 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 6.43235782414967e-44 1.52554086396083e-41 0.99396771430592 0.849829351535836 11.4 11 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 6.19816255504074e-12 7.05598825265838e-11 0.993366204438651 0.849315068493151 11.4 11 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.19816255504074e-12 7.05598825265838e-11 0.993366204438651 0.849315068493151 11.4 11 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.21422946807981e-15 3.14154278741376e-14 0.992395171980744 0.848484848484849 11.4 11 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 9.9449838214894e-13 1.22558313004096e-11 0.991946530402091 0.848101265822785 11.4 11 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 9.9449838214894e-13 1.22558313004096e-11 0.991946530402091 0.848101265822785 11.4 11 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 9.9449838214894e-13 1.22558313004096e-11 0.991946530402091 0.848101265822785 11.4 11 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 6.18919229080769e-08 3.56567636834791e-07 0.991624678834796 0.847826086956522 11.4 11 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.14727183569246e-11 1.26555645131036e-10 0.990918393451011 0.847222222222222 11.4 11 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.14727183569246e-11 1.26555645131036e-10 0.990918393451011 0.847222222222222 11.4 11 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.59829919744281e-13 2.36914558120949e-12 0.990727280935398 0.847058823529412 11.4 11 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.59829919744281e-13 2.36914558120949e-12 0.990727280935398 0.847058823529412 11.4 11 4 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 7.3432284208572e-07 3.60324622168269e-06 0.989668811618159 0.846153846153846 11.4 11 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 5.82091007307298e-05 0.000215700899397823 0.989668811618159 0.846153846153846 11.4 11 4 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00520029536636907 0.0116719563191533 0.989668811618159 0.846153846153846 11.4 11 4 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00520029536636907 0.0116719563191533 0.989668811618159 0.846153846153846 11.4 11 4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00520029536636907 0.0116719563191533 0.989668811618159 0.846153846153846 11.4 11 4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00520029536636907 0.0116719563191533 0.989668811618159 0.846153846153846 11.4 11 4 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00520029536636907 0.0116719563191533 0.989668811618159 0.846153846153846 11.4 11 4 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00520029536636907 0.0116719563191533 0.989668811618159 0.846153846153846 11.4 11 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.11847843231972e-11 2.28378394635679e-10 0.988401630041183 0.845070422535211 11.4 11 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.54099686219466e-09 1.16640347601223e-08 0.988117606584275 0.844827586206897 11.4 11 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.54099686219466e-09 1.16640347601223e-08 0.988117606584275 0.844827586206897 11.4 11 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.79730192404753e-08 1.16783590772586e-07 0.986140580560697 0.843137254901961 11.4 11 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000732093287616855 0.00213477202516145 0.984933554146302 0.842105263157895 11.4 11 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.19099299145036e-20 5.4670420220447e-19 0.984490688339582 0.841726618705036 11.4 11 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 9.99069874102259e-13 1.22558313004096e-11 0.984182842595886 0.841463414634146 11.4 11 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 3.64486533535359e-16 1.03732867444163e-14 0.983782930835383 0.841121495327103 11.4 11 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 7.16932015921736e-11 6.7118043332673e-10 0.98314925422937 0.840579710144927 11.4 11 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.71802218750582e-60 1.6784363932052e-57 0.982910509874288 0.84037558685446 11.4 11 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000107693226306718 0.000377456800577489 0.982471220260936 0.84 11.4 11 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000107693226306718 0.000377456800577489 0.982471220260936 0.84 11.4 11 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.93868704219607e-13 3.90817912247197e-12 0.98139571810411 0.839080459770115 11.4 11 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.93868704219607e-13 3.90817912247197e-12 0.98139571810411 0.839080459770115 11.4 11 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 5.28362703920043e-37 8.3540014186469e-35 0.98139571810411 0.839080459770115 11.4 11 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 8.25913952121768e-10 6.63997488061738e-09 0.980962047879583 0.838709677419355 11.4 11 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 1.62505573947834e-05 6.5565054643431e-05 0.980962047879583 0.838709677419355 11.4 11 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 9.54006047617271e-09 6.31210753310727e-08 0.978218098095304 0.836363636363636 11.4 11 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 9.54006047617271e-09 6.31210753310727e-08 0.978218098095304 0.836363636363636 11.4 11 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.51039504921978e-09 1.15553341668803e-08 0.977869481524351 0.836065573770492 11.4 11 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.51039504921978e-09 1.15553341668803e-08 0.977869481524351 0.836065573770492 11.4 11 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.51039504921978e-09 1.15553341668803e-08 0.977869481524351 0.836065573770492 11.4 11 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 6.12121885016774e-12 7.05598825265838e-11 0.977141358306537 0.835443037974684 11.4 11 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.75866285931772e-18 9.57457865563199e-17 0.976208749040675 0.834645669291339 11.4 11 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.45682820758549e-19 1.71407203767409e-17 0.97613950455571 0.834586466165414 11.4 11 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.86617337469406e-13 3.90817912247197e-12 0.974673829623945 0.833333333333333 11.4 11 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.974511415456e-11 6.7118043332673e-10 0.974673829623945 0.833333333333333 11.4 11 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.75374264462648e-09 1.94954019069825e-08 0.974673829623945 0.833333333333333 11.4 11 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.75374264462648e-09 1.94954019069825e-08 0.974673829623945 0.833333333333333 11.4 11 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.75374264462648e-09 1.94954019069825e-08 0.974673829623945 0.833333333333333 11.4 11 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.75374264462648e-09 1.94954019069825e-08 0.974673829623945 0.833333333333333 11.4 11 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.75374264462648e-09 1.94954019069825e-08 0.974673829623945 0.833333333333333 11.4 11 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.75374264462648e-09 1.94954019069825e-08 0.974673829623945 0.833333333333333 11.4 11 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.75374264462648e-09 1.94954019069825e-08 0.974673829623945 0.833333333333333 11.4 11 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.75374264462648e-09 1.94954019069825e-08 0.974673829623945 0.833333333333333 11.4 11 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.74032851613154e-08 1.13600343048403e-07 0.974673829623945 0.833333333333333 11.4 11 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.10557551579021e-07 6.20258806535829e-07 0.974673829623945 0.833333333333333 11.4 11 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.97873195084977e-05 0.000116448779287341 0.974673829623945 0.833333333333333 11.4 11 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.000197925577308023 0.000659597415712685 0.974673829623945 0.833333333333333 11.4 11 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000197925577308023 0.000659597415712685 0.974673829623945 0.833333333333333 11.4 11 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000197925577308023 0.000659597415712685 0.974673829623945 0.833333333333333 11.4 11 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000197925577308023 0.000659597415712685 0.974673829623945 0.833333333333333 11.4 11 4 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000197925577308023 0.000659597415712685 0.974673829623945 0.833333333333333 11.4 11 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0013511574116011 0.00364290908226624 0.974673829623945 0.833333333333333 11.4 11 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0013511574116011 0.00364290908226624 0.974673829623945 0.833333333333333 11.4 11 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0013511574116011 0.00364290908226624 0.974673829623945 0.833333333333333 11.4 11 4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00967109054084301 0.0197445650496694 0.974673829623945 0.833333333333333 11.4 11 4 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00967109054084301 0.0197445650496694 0.974673829623945 0.833333333333333 11.4 11 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00967109054084301 0.0197445650496694 0.974673829623945 0.833333333333333 11.4 11 4 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00967109054084301 0.0197445650496694 0.974673829623945 0.833333333333333 11.4 11 4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00967109054084301 0.0197445650496694 0.974673829623945 0.833333333333333 11.4 11 4 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00967109054084301 0.0197445650496694 0.974673829623945 0.833333333333333 11.4 11 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%REACT_226440.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_217410.1 ACTIVATION OF TRKA RECEPTORS 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.0768521038944922 0.120308629088958 0.974673829623945 0.833333333333333 11.4 11 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.02809344572078e-25 1.44298848663034e-23 0.972554973472588 0.831521739130435 11.4 11 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 5.00480244717836e-09 3.4910950403602e-08 0.971369850540474 0.830508474576271 11.4 11 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 5.00480244717836e-09 3.4910950403602e-08 0.971369850540474 0.830508474576271 11.4 11 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 3.16374768453937e-08 1.96594452187752e-07 0.970995815172534 0.830188679245283 11.4 11 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.44196013721591e-14 3.90439244411038e-13 0.970775134305449 0.83 11.4 11 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.28633941737809e-06 6.16316831962635e-06 0.969919323137974 0.829268292682927 11.4 11 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.28633941737809e-06 6.16316831962635e-06 0.969919323137974 0.829268292682927 11.4 11 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 3.6701185325046e-11 3.86857679389189e-10 0.969543967362766 0.828947368421053 11.4 11 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 8.3044128883283e-06 3.55455772426194e-05 0.969104264883237 0.828571428571429 11.4 11 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 8.3044128883283e-06 3.55455772426194e-05 0.969104264883237 0.828571428571429 11.4 11 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.4403797117127e-09 1.12003296708589e-08 0.968582118188795 0.828125 11.4 11 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.4403797117127e-09 1.12003296708589e-08 0.968582118188795 0.828125 11.4 11 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.07586358300682e-15 5.02385284525335e-14 0.967585292681225 0.827272727272727 11.4 11 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.28637369713592e-14 2.23232898905417e-13 0.967176338626837 0.826923076923077 11.4 11 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.14855933734679e-10 3.43220926572354e-09 0.966198405018519 0.826086956521739 11.4 11 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 4.14855933734679e-10 3.43220926572354e-09 0.966198405018519 0.826086956521739 11.4 11 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.14855933734679e-10 3.43220926572354e-09 0.966198405018519 0.826086956521739 11.4 11 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.60155290834757e-09 1.91813978682829e-08 0.965391221722764 0.825396825396825 11.4 11 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 2.32956303423271e-06 1.09045006503722e-05 0.964927091327705 0.825 11.4 11 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.19572518906842e-10 1.09071598977203e-09 0.964136815249632 0.824324324324324 11.4 11 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.19572518906842e-10 1.09071598977203e-09 0.964136815249632 0.824324324324324 11.4 11 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 1.50379333244595e-05 6.16685277253773e-05 0.963207078687192 0.823529411764706 11.4 11 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.50379333244595e-05 6.16685277253773e-05 0.963207078687192 0.823529411764706 11.4 11 4 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00247083842703925 0.00601026167808009 0.963207078687192 0.823529411764706 11.4 11 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00247083842703925 0.00601026167808009 0.963207078687192 0.823529411764706 11.4 11 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00247083842703925 0.00601026167808009 0.963207078687192 0.823529411764706 11.4 11 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00247083842703925 0.00601026167808009 0.963207078687192 0.823529411764706 11.4 11 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00247083842703925 0.00601026167808009 0.963207078687192 0.823529411764706 11.4 11 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.44871091613731e-11 3.66232509974881e-10 0.962336186210984 0.822784810126582 11.4 11 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.94483969597808e-08 1.84603827637745e-07 0.960749917772174 0.821428571428571 11.4 11 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 9.82786077758093e-05 0.000347886713594469 0.960749917772174 0.821428571428571 11.4 11 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.34224468088929e-13 2.03192997968666e-12 0.959079048349962 0.82 11.4 11 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.72973428252956e-65 8.20470628013189e-63 0.958367499394495 0.819391634980989 11.4 11 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.17919595762244e-06 5.68812151761602e-06 0.956952487267146 0.818181818181818 11.4 11 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000653831209013312 0.00194238373784122 0.956952487267146 0.818181818181818 11.4 11 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000653831209013312 0.00194238373784122 0.956952487267146 0.818181818181818 11.4 11 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000653831209013312 0.00194238373784122 0.956952487267146 0.818181818181818 11.4 11 4 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0177561146421186 0.0337342471772159 0.956952487267146 0.818181818181818 11.4 11 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 5.27877962444571e-08 3.1168893799113e-07 0.956952487267146 0.818181818181818 11.4 11 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 5.27877962444571e-08 3.1168893799113e-07 0.956952487267146 0.818181818181818 11.4 11 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.27877962444571e-08 3.1168893799113e-07 0.956952487267146 0.818181818181818 11.4 11 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 5.27877962444571e-08 3.1168893799113e-07 0.956952487267146 0.818181818181818 11.4 11 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 2.70776920840243e-05 0.000106147536737098 0.956952487267146 0.818181818181818 11.4 11 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.28125641826575e-13 5.63401789801649e-12 0.954782526978558 0.816326530612245 11.4 11 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 3.3276656350547e-07 1.6911672138153e-06 0.954782526978558 0.816326530612245 11.4 11 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 8.22239151836757e-34 1.06367846642155e-31 0.954607015484628 0.816176470588235 11.4 11 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 9.42679202553379e-08 5.36573002093383e-07 0.953014411187857 0.814814814814815 11.4 11 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000176741522363838 0.000595979114511236 0.953014411187857 0.814814814814815 11.4 11 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000176741522363838 0.000595979114511236 0.953014411187857 0.814814814814815 11.4 11 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.22710636664488e-09 9.64736110351194e-09 0.952395570661112 0.814285714285714 11.4 11 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 2.10751984125817e-06 9.96345758840657e-06 0.952006996376876 0.813953488372093 11.4 11 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00447207468378913 0.0101983369792178 0.950306983883346 0.8125 11.4 11 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00447207468378913 0.0101983369792178 0.950306983883346 0.8125 11.4 11 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00447207468378913 0.0101983369792178 0.950306983883346 0.8125 11.4 11 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.00854939309702e-10 9.31925835309783e-10 0.950306983883346 0.8125 11.4 11 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 8.3174891874889e-20 3.69868347306147e-18 0.948927728464067 0.811320754716981 11.4 11 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00117360920376074 0.00322402682809177 0.946826005920403 0.80952380952381 11.4 11 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00117360920376074 0.00322402682809177 0.946826005920403 0.80952380952381 11.4 11 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00117360920376074 0.00322402682809177 0.946826005920403 0.80952380952381 11.4 11 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00117360920376074 0.00322402682809177 0.946826005920403 0.80952380952381 11.4 11 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00117360920376074 0.00322402682809177 0.946826005920403 0.80952380952381 11.4 11 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00117360920376074 0.00322402682809177 0.946826005920403 0.80952380952381 11.4 11 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 8.98630111200658e-19 3.27884781599625e-17 0.946459587187462 0.809210526315789 11.4 11 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.74508012940216e-14 8.98379013641679e-13 0.946319681853066 0.809090909090909 11.4 11 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.60134883054269e-19 1.02825538496174e-17 0.94611650722732 0.808917197452229 11.4 11 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.99847813796389e-22 1.42227813010754e-20 0.945912962520287 0.808743169398907 11.4 11 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.99847813796389e-22 1.42227813010754e-20 0.945912962520287 0.808743169398907 11.4 11 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.05272185163855e-06 5.11198012063048e-06 0.945640992145785 0.808510638297872 11.4 11 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.97057029427448e-07 1.52054731250093e-06 0.944683865635516 0.807692307692308 11.4 11 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.97057029427448e-07 1.52054731250093e-06 0.944683865635516 0.807692307692308 11.4 11 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000315526553725871 0.00100221938828552 0.944683865635516 0.807692307692308 11.4 11 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000315526553725871 0.00100221938828552 0.944683865635516 0.807692307692308 11.4 11 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000315526553725871 0.00100221938828552 0.944683865635516 0.807692307692308 11.4 11 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 9.05684089521289e-11 8.4234539829333e-10 0.94414187833452 0.807228915662651 11.4 11 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.43744310800168e-15 5.02385284525335e-14 0.943232738345753 0.806451612903226 11.4 11 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 8.6190494982307e-05 0.000309719884747027 0.943232738345753 0.806451612903226 11.4 11 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.04139252043892e-16 1.96468657972247e-14 0.942940263078049 0.806201550387597 11.4 11 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 6.81265547719733e-09 4.59450651376862e-08 0.94266961432286 0.805970149253731 11.4 11 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 5.88207376809758e-17 1.94655604000066e-15 0.942418436701138 0.805755395683453 11.4 11 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.38104453718975e-05 9.43795648028139e-05 0.942184701969813 0.805555555555556 11.4 11 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 2.38104453718975e-05 9.43795648028139e-05 0.942184701969813 0.805555555555556 11.4 11 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.38104453718975e-05 9.43795648028139e-05 0.942184701969813 0.805555555555556 11.4 11 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 6.63286045375799e-06 2.91313593385729e-05 0.941392284222152 0.804878048780488 11.4 11 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.85961036220512e-06 8.8502526602605e-06 0.940772131202242 0.804347826086957 11.4 11 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.15065662915154e-22 1.09299442260094e-20 0.938123561013047 0.802083333333333 11.4 11 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.31837715714767e-14 2.26030204171221e-13 0.937620113787001 0.801652892561983 11.4 11 4 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00800091231707918 0.0169172336214022 0.935686876438987 0.8 11.4 11 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00800091231707918 0.0169172336214022 0.935686876438987 0.8 11.4 11 4 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00800091231707918 0.0169172336214022 0.935686876438987 0.8 11.4 11 4 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00800091231707918 0.0169172336214022 0.935686876438987 0.8 11.4 11 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00800091231707918 0.0169172336214022 0.935686876438987 0.8 11.4 11 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00800091231707918 0.0169172336214022 0.935686876438987 0.8 11.4 11 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00800091231707918 0.0169172336214022 0.935686876438987 0.8 11.4 11 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 3.86011171812566e-25 2.38823433690992e-23 0.935686876438987 0.8 11.4 11 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.6045290814387e-16 4.85796783593035e-15 0.935686876438987 0.8 11.4 11 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.6045290814387e-16 4.85796783593035e-15 0.935686876438987 0.8 11.4 11 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.10038732820769e-08 1.34632935497277e-07 0.935686876438987 0.8 11.4 11 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.000558854981313241 0.00167774396288764 0.935686876438987 0.8 11.4 11 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000558854981313241 0.00167774396288764 0.935686876438987 0.8 11.4 11 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000558854981313241 0.00167774396288764 0.935686876438987 0.8 11.4 11 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.16741496635069e-05 4.87164661911155e-05 0.935686876438987 0.8 11.4 11 4 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00208689061053677 0.00521906034937404 0.935686876438987 0.8 11.4 11 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00208689061053677 0.00521906034937404 0.935686876438987 0.8 11.4 11 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00208689061053677 0.00521906034937404 0.935686876438987 0.8 11.4 11 4 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00208689061053677 0.00521906034937404 0.935686876438987 0.8 11.4 11 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00208689061053677 0.00521906034937404 0.935686876438987 0.8 11.4 11 4 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.032110809020036 0.0556561281796726 0.935686876438987 0.8 11.4 11 4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.032110809020036 0.0556561281796726 0.935686876438987 0.8 11.4 11 4 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.032110809020036 0.0556561281796726 0.935686876438987 0.8 11.4 11 4 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.032110809020036 0.0556561281796726 0.935686876438987 0.8 11.4 11 4 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.032110809020036 0.0556561281796726 0.935686876438987 0.8 11.4 11 4 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.032110809020036 0.0556561281796726 0.935686876438987 0.8 11.4 11 4 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.032110809020036 0.0556561281796726 0.935686876438987 0.8 11.4 11 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.032110809020036 0.0556561281796726 0.935686876438987 0.8 11.4 11 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.40286847246646e-25 2.20103719832717e-23 0.933588923801231 0.798206278026906 11.4 11 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 4.83403679205465e-13 6.25348577735797e-12 0.933540805621466 0.798165137614679 11.4 11 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.82525905392723e-12 6.7945439620807e-11 0.933324030791414 0.797979797979798 11.4 11 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.71766827761935e-06 2.51896035883973e-05 0.930370473731947 0.795454545454545 11.4 11 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.71766827761935e-06 2.51896035883973e-05 0.930370473731947 0.795454545454545 11.4 11 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 5.20163767514699e-09 3.59317010278357e-08 0.929278062216802 0.794520547945205 11.4 11 4 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000981399150707322 0.00275994267086269 0.925940138142748 0.791666666666667 11.4 11 4 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000981399150707322 0.00275994267086269 0.925940138142748 0.791666666666667 11.4 11 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.000981399150707322 0.00275994267086269 0.925940138142748 0.791666666666667 11.4 11 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 3.55451565920302e-05 0.000137447711495813 0.923375207012158 0.789473684210526 11.4 11 4 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.003672647876542 0.00855348269774021 0.923375207012158 0.789473684210526 11.4 11 4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.003672647876542 0.00855348269774021 0.923375207012158 0.789473684210526 11.4 11 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.003672647876542 0.00855348269774021 0.923375207012158 0.789473684210526 11.4 11 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.003672647876542 0.00855348269774021 0.923375207012158 0.789473684210526 11.4 11 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 9.07998997664509e-14 1.38933610072752e-12 0.92237425827827 0.788617886178862 11.4 11 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 9.07998997664509e-14 1.38933610072752e-12 0.92237425827827 0.788617886178862 11.4 11 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000127901939647409 0.000438564964140392 0.921509802553548 0.787878787878788 11.4 11 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.52306733724231e-14 7.15147202321757e-13 0.920951650038373 0.78740157480315 11.4 11 4 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0141274713088094 0.0274261823634868 0.918978182216862 0.785714285714286 11.4 11 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.26675050446993e-19 3.09568051785808e-17 0.918506185204938 0.785310734463277 11.4 11 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 7.78260832066011e-27 6.51450096488196e-25 0.91769289804593 0.784615384615385 11.4 11 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 2.36131893994309e-06 1.1016907709964e-05 0.917340074940183 0.784313725490196 11.4 11 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 8.34309402602592e-06 3.55455772426194e-05 0.915345857385965 0.782608695652174 11.4 11 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 8.34309402602592e-06 3.55455772426194e-05 0.915345857385965 0.782608695652174 11.4 11 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 8.34309402602592e-06 3.55455772426194e-05 0.915345857385965 0.782608695652174 11.4 11 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 8.34309402602592e-06 3.55455772426194e-05 0.915345857385965 0.782608695652174 11.4 11 4 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00170748630310288 0.00443385585641495 0.915345857385965 0.782608695652174 11.4 11 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 6.50946532832232e-09 4.45335055875128e-08 0.914693901647087 0.782051282051282 11.4 11 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.607602666916e-07 8.44139702959951e-07 0.913756715272448 0.78125 11.4 11 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000220925642460621 0.000721048599131798 0.913756715272448 0.78125 11.4 11 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.000220925642460621 0.000721048599131798 0.913756715272448 0.78125 11.4 11 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000220925642460621 0.000721048599131798 0.913756715272448 0.78125 11.4 11 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 4.04994787171288e-06 1.84713968636135e-05 0.912294704528012 0.78 11.4 11 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 2.24815868549602e-10 1.91564659249152e-09 0.911063537585329 0.778947368421053 11.4 11 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.8573309378778e-16 8.29792229510226e-15 0.910518083876546 0.778481012658228 11.4 11 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000801274163492983 0.00229881680373088 0.909695574315682 0.777777777777778 11.4 11 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000801274163492983 0.00229881680373088 0.909695574315682 0.777777777777778 11.4 11 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000801274163492983 0.00229881680373088 0.909695574315682 0.777777777777778 11.4 11 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000105537509008787 0.000371732364652239 0.909695574315682 0.777777777777778 11.4 11 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00638972198107277 0.0138185020958458 0.909695574315682 0.777777777777778 11.4 11 4 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0570298751219076 0.092535361799857 0.909695574315682 0.777777777777778 11.4 11 4 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0570298751219076 0.092535361799857 0.909695574315682 0.777777777777778 11.4 11 4 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0570298751219076 0.092535361799857 0.909695574315682 0.777777777777778 11.4 11 4 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0570298751219076 0.092535361799857 0.909695574315682 0.777777777777778 11.4 11 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.89125528579415e-08 1.21776301886203e-07 0.907985620228622 0.776315789473684 11.4 11 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 5.05947904457368e-05 0.000190971848287224 0.906446661550269 0.775 11.4 11 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 5.05947904457368e-05 0.000190971848287224 0.906446661550269 0.775 11.4 11 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 5.05947904457368e-05 0.000190971848287224 0.906446661550269 0.775 11.4 11 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00294085438590199 0.00696312111670304 0.903788460196749 0.772727272727273 11.4 11 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 8.59246991004364e-05 0.000309546447645369 0.899698919652872 0.769230769230769 11.4 11 4 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0013699497399378 0.00364290908226624 0.899698919652872 0.769230769230769 11.4 11 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.0013699497399378 0.00364290908226624 0.899698919652872 0.769230769230769 11.4 11 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0013699497399378 0.00364290908226624 0.899698919652872 0.769230769230769 11.4 11 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0013699497399378 0.00364290908226624 0.899698919652872 0.769230769230769 11.4 11 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0013699497399378 0.00364290908226624 0.899698919652872 0.769230769230769 11.4 11 4 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0245737411224227 0.0432242689953121 0.899698919652872 0.769230769230769 11.4 11 4 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0245737411224227 0.0432242689953121 0.899698919652872 0.769230769230769 11.4 11 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0245737411224227 0.0432242689953121 0.899698919652872 0.769230769230769 11.4 11 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0245737411224227 0.0432242689953121 0.899698919652872 0.769230769230769 11.4 11 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0245737411224227 0.0432242689953121 0.899698919652872 0.769230769230769 11.4 11 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.62340106983219e-15 4.12517807566286e-14 0.899136607828089 0.76875 11.4 11 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.86991665203669e-07 9.74685492984692e-07 0.898395008175114 0.768115942028985 11.4 11 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 4.11738154317383e-05 0.000157078657799902 0.897606596583912 0.767441860465116 11.4 11 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000643847239943484 0.00192477861857054 0.896699923254029 0.766666666666667 11.4 11 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.59622450246727e-23 1.96824133346574e-21 0.895771662463911 0.765873015873016 11.4 11 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.59622450246727e-23 1.96824133346574e-21 0.895771662463911 0.765873015873016 11.4 11 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.59622450246727e-23 1.96824133346574e-21 0.895771662463911 0.765873015873016 11.4 11 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.17141703253458e-08 1.38561723645592e-07 0.895255962024957 0.765432098765432 11.4 11 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 3.13907468606617e-07 1.60104060153124e-06 0.894406573066679 0.764705882352941 11.4 11 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00030465376834958 0.000974207443508881 0.894406573066679 0.764705882352941 11.4 11 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00030465376834958 0.000974207443508881 0.894406573066679 0.764705882352941 11.4 11 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00030465376834958 0.000974207443508881 0.894406573066679 0.764705882352941 11.4 11 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00030465376834958 0.000974207443508881 0.894406573066679 0.764705882352941 11.4 11 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00030465376834958 0.000974207443508881 0.894406573066679 0.764705882352941 11.4 11 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00030465376834958 0.000974207443508881 0.894406573066679 0.764705882352941 11.4 11 4 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0109760925182262 0.0218142173930669 0.894406573066679 0.764705882352941 11.4 11 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0109760925182262 0.0218142173930669 0.894406573066679 0.764705882352941 11.4 11 4 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0109760925182262 0.0218142173930669 0.894406573066679 0.764705882352941 11.4 11 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 5.18751928591269e-09 3.59317010278357e-08 0.893633533677684 0.764044943820225 11.4 11 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00500939111222009 0.0113508973768936 0.891130358513321 0.761904761904762 11.4 11 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.46071848138315e-10 1.29912649938014e-09 0.890619389271054 0.761467889908257 11.4 11 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.11667009259165e-14 3.54355475500932e-13 0.890411704998391 0.761290322580645 11.4 11 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.72334719225606e-11 1.87200233174074e-10 0.88928918008664 0.760330578512397 11.4 11 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.72334719225606e-11 1.87200233174074e-10 0.88928918008664 0.760330578512397 11.4 11 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00231945568712192 0.00569066455650775 0.888902532617038 0.76 11.4 11 4 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00231945568712192 0.00569066455650775 0.888902532617038 0.76 11.4 11 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00231945568712192 0.00569066455650775 0.888902532617038 0.76 11.4 11 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 7.25485823956009e-17 2.34628710793046e-15 0.888151981646632 0.759358288770054 11.4 11 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 7.69918715434975e-06 3.35044138245862e-05 0.888036155879594 0.759259259259259 11.4 11 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00108512367836614 0.00301982836191589 0.887289279381798 0.758620689655172 11.4 11 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00108512367836614 0.00301982836191589 0.887289279381798 0.758620689655172 11.4 11 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000511624713751904 0.00155232828927283 0.88606711783995 0.757575757575758 11.4 11 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000242692517179185 0.000786677567075126 0.885109207442285 0.756756756756757 11.4 11 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000242692517179185 0.000786677567075126 0.885109207442285 0.756756756756757 11.4 11 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.14505278543497e-14 2.01161742428885e-13 0.884338206390506 0.75609756097561 11.4 11 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 4.89138646999709e-08 2.93689575814593e-07 0.884338206390506 0.75609756097561 11.4 11 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000115682566914305 0.000397623895456658 0.884338206390506 0.75609756097561 11.4 11 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000115682566914305 0.000397623895456658 0.884338206390506 0.75609756097561 11.4 11 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000115682566914305 0.000397623895456658 0.884338206390506 0.75609756097561 11.4 11 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000115682566914305 0.000397623895456658 0.884338206390506 0.75609756097561 11.4 11 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000115682566914305 0.000397623895456658 0.884338206390506 0.75609756097561 11.4 11 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000115682566914305 0.000397623895456658 0.884338206390506 0.75609756097561 11.4 11 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.38558753982763e-08 1.515487084453e-07 0.884006496635671 0.755813953488372 11.4 11 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 5.53606502916013e-05 0.00020622566849463 0.883704272192377 0.755555555555556 11.4 11 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.279784784357e-05 5.32495247994156e-05 0.882723468338667 0.754716981132076 11.4 11 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.59544486538174e-10 1.41013543070697e-09 0.882336308922729 0.754385964912281 11.4 11 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 8.08165303073962e-08 4.63717429949293e-07 0.880816349734232 0.753086419753086 11.4 11 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.9394274600361e-08 2.38544905346016e-07 0.880646471942576 0.752941176470588 11.4 11 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.9394274600361e-08 2.38544905346016e-07 0.880646471942576 0.752941176470588 11.4 11 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.9394274600361e-08 2.38544905346016e-07 0.880646471942576 0.752941176470588 11.4 11 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.9394274600361e-08 2.38544905346016e-07 0.880646471942576 0.752941176470588 11.4 11 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.9394274600361e-08 2.38544905346016e-07 0.880646471942576 0.752941176470588 11.4 11 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 3.16118001319384e-08 1.96594452187752e-07 0.87720644666155 0.75 11.4 11 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 8.81631911668731e-10 7.04810230508205e-09 0.87720644666155 0.75 11.4 11 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 4.3981630546776e-05 0.000167341872374498 0.87720644666155 0.75 11.4 11 4 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0420111869459452 0.0706642068842554 0.87720644666155 0.75 11.4 11 4 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0420111869459452 0.0706642068842554 0.87720644666155 0.75 11.4 11 4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0420111869459452 0.0706642068842554 0.87720644666155 0.75 11.4 11 4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0420111869459452 0.0706642068842554 0.87720644666155 0.75 11.4 11 4 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.0420111869459452 0.0706642068842554 0.87720644666155 0.75 11.4 11 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.80169379216143e-09 1.34937382433985e-08 0.87720644666155 0.75 11.4 11 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.61982955997005e-07 2.77674217494354e-06 0.87720644666155 0.75 11.4 11 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 5.61982955997005e-07 2.77674217494354e-06 0.87720644666155 0.75 11.4 11 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00181178002641208 0.00465372378625342 0.87720644666155 0.75 11.4 11 4 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00181178002641208 0.00465372378625342 0.87720644666155 0.75 11.4 11 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00181178002641208 0.00465372378625342 0.87720644666155 0.75 11.4 11 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00181178002641208 0.00465372378625342 0.87720644666155 0.75 11.4 11 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0185874252169493 0.0351260372957753 0.87720644666155 0.75 11.4 11 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0185874252169493 0.0351260372957753 0.87720644666155 0.75 11.4 11 4 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0185874252169493 0.0351260372957753 0.87720644666155 0.75 11.4 11 4 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0185874252169493 0.0351260372957753 0.87720644666155 0.75 11.4 11 4 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.0990851170918717 0.147642012169354 0.87720644666155 0.75 11.4 11 4 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0990851170918717 0.147642012169354 0.87720644666155 0.75 11.4 11 4 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.0990851170918717 0.147642012169354 0.87720644666155 0.75 11.4 11 4 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0990851170918717 0.147642012169354 0.87720644666155 0.75 11.4 11 4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0990851170918717 0.147642012169354 0.87720644666155 0.75 11.4 11 4 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.0990851170918717 0.147642012169354 0.87720644666155 0.75 11.4 11 4 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00842991967455772 0.0176408466130818 0.87720644666155 0.75 11.4 11 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00842991967455772 0.0176408466130818 0.87720644666155 0.75 11.4 11 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00842991967455772 0.0176408466130818 0.87720644666155 0.75 11.4 11 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00842991967455772 0.0176408466130818 0.87720644666155 0.75 11.4 11 4 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00842991967455772 0.0176408466130818 0.87720644666155 0.75 11.4 11 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00842991967455772 0.0176408466130818 0.87720644666155 0.75 11.4 11 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.35788103257177e-10 1.21526082349033e-09 0.872412968810941 0.745901639344262 11.4 11 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.88247815156001e-68 3.47388320483495e-65 0.871914100075357 0.745475113122172 11.4 11 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.73408246905307e-59 4.93519870692504e-57 0.870092950081708 0.743918053777209 11.4 11 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 5.95521608222905e-13 7.63447971622697e-12 0.869708955664443 0.743589743589744 11.4 11 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 1.50525118351157e-06 7.18782696019117e-06 0.868852099550488 0.742857142857143 11.4 11 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000664821620469098 0.00197091909568235 0.868852099550488 0.742857142857143 11.4 11 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.76204675698095e-10 1.51963183950539e-09 0.867774119278093 0.741935483870968 11.4 11 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.76204675698095e-10 1.51963183950539e-09 0.867774119278093 0.741935483870968 11.4 11 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.76204675698095e-10 1.51963183950539e-09 0.867774119278093 0.741935483870968 11.4 11 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00140616029419328 0.00370549277525377 0.867774119278093 0.741935483870968 11.4 11 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.3761628179918e-07 7.25288774074937e-07 0.866886370818473 0.741176470588235 11.4 11 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.3761628179918e-07 7.25288774074937e-07 0.866886370818473 0.741176470588235 11.4 11 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00299473710120872 0.00704381966119011 0.866376737443507 0.740740740740741 11.4 11 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00299473710120872 0.00704381966119011 0.866376737443507 0.740740740740741 11.4 11 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00299473710120872 0.00704381966119011 0.866376737443507 0.740740740740741 11.4 11 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00299473710120872 0.00704381966119011 0.866376737443507 0.740740740740741 11.4 11 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 5.67851495476051e-05 0.000210979811504548 0.865510360706063 0.74 11.4 11 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.91930273036926e-115 4.15416778531545e-112 0.865314041639024 0.739832149774048 11.4 11 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 5.32048234093989e-08 3.12853155832953e-07 0.864493309753412 0.739130434782609 11.4 11 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00643539728716618 0.0138961613651555 0.864493309753412 0.739130434782609 11.4 11 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 2.19036857261118e-19 9.05591382841179e-18 0.862299670443772 0.737254901960784 11.4 11 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00108654400653614 0.00301982836191589 0.860006320256422 0.735294117647059 11.4 11 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 3.59926520171829e-07 1.80980720213609e-06 0.85959185937919 0.734939759036145 11.4 11 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.71110617654458e-11 2.90067976633303e-10 0.858803514214105 0.734265734265734 11.4 11 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 8.44734044693161e-16 2.26803121811013e-14 0.857712970069071 0.733333333333333 11.4 11 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 8.44734044693161e-16 2.26803121811013e-14 0.857712970069071 0.733333333333333 11.4 11 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00229863388402844 0.0056689012425866 0.857712970069071 0.733333333333333 11.4 11 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 7.1706090567296e-05 0.000263663480303003 0.854713973670228 0.730769230769231 11.4 11 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00489668611519309 0.0111309654024277 0.854713973670228 0.730769230769231 11.4 11 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00489668611519309 0.0111309654024277 0.854713973670228 0.730769230769231 11.4 11 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 7.91523467118841e-09 5.30649978298542e-08 0.853498164319346 0.72972972972973 11.4 11 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000148615508868658 0.000505932701244261 0.852839600920952 0.729166666666667 11.4 11 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.93684182419264e-39 8.00303702260876e-37 0.852114143166853 0.728546409807356 11.4 11 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.19211995746513e-36 1.69638669947289e-34 0.852018246570145 0.728464419475655 11.4 11 4 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0703899940278156 0.112925548479799 0.850624433126352 0.727272727272727 11.4 11 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0703899940278156 0.112925548479799 0.850624433126352 0.727272727272727 11.4 11 4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0703899940278156 0.112925548479799 0.850624433126352 0.727272727272727 11.4 11 4 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0703899940278156 0.112925548479799 0.850624433126352 0.727272727272727 11.4 11 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 4.56370273722836e-10 3.71094228290055e-09 0.850624433126352 0.727272727272727 11.4 11 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.02072288663815e-05 4.27202549319437e-05 0.850624433126352 0.727272727272727 11.4 11 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.00175967683723067 0.00455276388978043 0.850624433126352 0.727272727272727 11.4 11 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00175967683723067 0.00455276388978043 0.850624433126352 0.727272727272727 11.4 11 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.35853825705358e-07 7.21343261114645e-07 0.849505190451185 0.726315789473684 11.4 11 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.09685787378822e-05 8.38154144494562e-05 0.848909464511178 0.725806451612903 11.4 11 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.38803675942234e-25 1.61817919459905e-23 0.847497137416328 0.724598930481283 11.4 11 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00371925294003273 0.00864787080664473 0.846957948500807 0.724137931034483 11.4 11 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.62645567738097e-05 6.5565054643431e-05 0.8457169844737 0.723076923076923 11.4 11 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00134475548075191 0.00364290908226624 0.844717319007419 0.722222222222222 11.4 11 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0229006559148253 0.0405823578664962 0.844717319007419 0.722222222222222 11.4 11 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0229006559148253 0.0405823578664962 0.844717319007419 0.722222222222222 11.4 11 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0229006559148253 0.0405823578664962 0.844717319007419 0.722222222222222 11.4 11 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.30773858645547e-07 6.96970789710164e-07 0.842118188795088 0.72 11.4 11 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00102650159936465 0.00286976773260491 0.839718991676014 0.717948717948718 11.4 11 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00102650159936465 0.00286976773260491 0.839718991676014 0.717948717948718 11.4 11 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00102650159936465 0.00286976773260491 0.839718991676014 0.717948717948718 11.4 11 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.000378345799191855 0.00118067121107458 0.839067035937135 0.717391304347826 11.4 11 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000140796981497605 0.000481620443920895 0.838587294921734 0.716981132075472 11.4 11 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.17064971936735e-07 2.07511697575516e-06 0.837193521024357 0.715789473684211 11.4 11 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.17064971936735e-07 2.07511697575516e-06 0.837193521024357 0.715789473684211 11.4 11 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 4.75181534503305e-08 2.86518357456866e-07 0.835434711106238 0.714285714285714 11.4 11 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 1.5341622477026e-05 6.27331286919769e-05 0.835434711106238 0.714285714285714 11.4 11 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00214084997170375 0.00534461317497269 0.835434711106238 0.714285714285714 11.4 11 4 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0059521297882003 0.0129707208095085 0.835434711106238 0.714285714285714 11.4 11 4 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.050689415656456 0.0829092396311918 0.835434711106238 0.714285714285714 11.4 11 4 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.167523424941016 0.237910013663738 0.835434711106238 0.714285714285714 11.4 11 4 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.167523424941016 0.237910013663738 0.835434711106238 0.714285714285714 11.4 11 4 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.167523424941016 0.237910013663738 0.835434711106238 0.714285714285714 11.4 11 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.167523424941016 0.237910013663738 0.835434711106238 0.714285714285714 11.4 11 4 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.167523424941016 0.237910013663738 0.835434711106238 0.714285714285714 11.4 11 4 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.167523424941016 0.237910013663738 0.835434711106238 0.714285714285714 11.4 11 4 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.167523424941016 0.237910013663738 0.835434711106238 0.714285714285714 11.4 11 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.83625205972779e-14 3.11069842975314e-13 0.833936173507842 0.713004484304933 11.4 11 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000221731518966 0.000722022772285167 0.832221500678907 0.711538461538462 11.4 11 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 6.58166875111652e-09 4.45986411087562e-08 0.830332819740704 0.709923664122137 11.4 11 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 6.58166875111652e-09 4.45986411087562e-08 0.830332819740704 0.709923664122137 11.4 11 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.66805767159951e-06 1.24073400872095e-05 0.829606096842706 0.709302325581395 11.4 11 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.96489233270169e-09 1.46389622483482e-08 0.829509642233144 0.709219858156028 11.4 11 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.15508491730144e-07 6.20258806535829e-07 0.829358822298193 0.709090909090909 11.4 11 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 4.14417628039342e-06 1.86619077436704e-05 0.825606067446165 0.705882352941177 11.4 11 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 4.14417628039342e-06 1.86619077436704e-05 0.825606067446165 0.705882352941177 11.4 11 4 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0368546236938845 0.0633383206719778 0.825606067446165 0.705882352941177 11.4 11 4 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0368546236938845 0.0633383206719778 0.825606067446165 0.705882352941177 11.4 11 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.59514217257667e-07 1.80980720213609e-06 0.824295581624822 0.704761904761905 11.4 11 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.18555716576343e-06 1.47656281657373e-05 0.824042419591153 0.704545454545455 11.4 11 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00941381502340593 0.0196420216690713 0.823057900571331 0.703703703703704 11.4 11 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.91554685848241e-06 2.17907264162632e-05 0.820070394580147 0.701149425287356 11.4 11 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000538409579145942 0.00162665993869358 0.818726016884114 0.7 11.4 11 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000538409579145942 0.00162665993869358 0.818726016884114 0.7 11.4 11 4 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.00703403073737605 0.0150971730607634 0.818726016884114 0.7 11.4 11 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00703403073737605 0.0150971730607634 0.818726016884114 0.7 11.4 11 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.115174362692941 0.170013608000058 0.818726016884114 0.7 11.4 11 4 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.115174362692941 0.170013608000058 0.818726016884114 0.7 11.4 11 4 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.115174362692941 0.170013608000058 0.818726016884114 0.7 11.4 11 4 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.115174362692941 0.170013608000058 0.818726016884114 0.7 11.4 11 4 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.115174362692941 0.170013608000058 0.818726016884114 0.7 11.4 11 4 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.115174362692941 0.170013608000058 0.818726016884114 0.7 11.4 11 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.94233820410254e-18 6.90986816109477e-17 0.818008465598501 0.699386503067485 11.4 11 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 2.58577870321819e-05 0.000102210085963319 0.815648099527406 0.697368421052632 11.4 11 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00526646908959499 0.01178331055738 0.815181748412754 0.696969696969697 11.4 11 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00526646908959499 0.01178331055738 0.815181748412754 0.696969696969697 11.4 11 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0198742702191304 0.0374088446055854 0.813640762120858 0.695652173913043 11.4 11 4 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00395015563295796 0.00916977400603455 0.812228191353287 0.694444444444444 11.4 11 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000829659832252221 0.00237069466123476 0.811565147931774 0.693877551020408 11.4 11 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.000829659832252221 0.00237069466123476 0.811565147931774 0.693877551020408 11.4 11 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 7.34004121145137e-26 5.49730454941858e-24 0.810456057117607 0.692929292929293 11.4 11 4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0812454400488708 0.126352198021359 0.809729027687585 0.692307692307692 11.4 11 4 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0812454400488708 0.126352198021359 0.809729027687585 0.692307692307692 11.4 11 4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0812454400488708 0.126352198021359 0.809729027687585 0.692307692307692 11.4 11 4 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0812454400488708 0.126352198021359 0.809729027687585 0.692307692307692 11.4 11 4 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0812454400488708 0.126352198021359 0.809729027687585 0.692307692307692 11.4 11 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00223262293420491 0.00552525640934538 0.807586887402697 0.69047619047619 11.4 11 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00223262293420491 0.00552525640934538 0.807586887402697 0.69047619047619 11.4 11 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.23469883969377e-09 4.28597896081364e-08 0.807407224023965 0.690322580645161 11.4 11 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0109140783396839 0.0217822348911222 0.806626617619816 0.689655172413793 11.4 11 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00126841307961981 0.00346439887197503 0.804105909439754 0.6875 11.4 11 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00126841307961981 0.00346439887197503 0.804105909439754 0.6875 11.4 11 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00812760463256235 0.0171596163088075 0.804105909439754 0.6875 11.4 11 4 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0582292918381281 0.0942665327481869 0.804105909439754 0.6875 11.4 11 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0582292918381281 0.0942665327481869 0.804105909439754 0.6875 11.4 11 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00606831343277493 0.0131634299006688 0.802017322661989 0.685714285714286 11.4 11 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0421907632038025 0.0707988868384563 0.80025851274387 0.684210526315789 11.4 11 4 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0421907632038025 0.0707988868384563 0.80025851274387 0.684210526315789 11.4 11 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00340459493428331 0.00798144743243023 0.798757089643038 0.682926829268293 11.4 11 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.86374013689581e-08 1.20550100672852e-07 0.79712178167971 0.681528662420382 11.4 11 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 1.34793636656955e-05 5.5919854513253e-05 0.796329256543819 0.680851063829787 11.4 11 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0226447538627306 0.0402793559333321 0.795333844973139 0.68 11.4 11 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0226447538627306 0.0402793559333321 0.795333844973139 0.68 11.4 11 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0226447538627306 0.0402793559333321 0.795333844973139 0.68 11.4 11 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.75114023798919e-13 2.56894078212228e-12 0.793813776040296 0.67870036101083 11.4 11 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0123969997015855 0.0245012924657725 0.792315500210433 0.67741935483871 11.4 11 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.1245304662902e-09 8.89003807517198e-09 0.791922486569455 0.677083333333333 11.4 11 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.00687762372526874 0.0148061400318569 0.790276078073469 0.675675675675676 11.4 11 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00289120104590452 0.00685696514720356 0.788214488304581 0.673913043478261 11.4 11 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00163601493990094 0.00426382648256234 0.787236554696263 0.673076923076923 11.4 11 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00123307976195662 0.00338087187141478 0.786827600641875 0.672727272727273 11.4 11 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000702780734799598 0.00205350510394215 0.786130367499969 0.672131147540984 11.4 11 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.82067970782246e-27 6.0661420151446e-25 0.782164379604907 0.668740279937792 11.4 11 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0186741735442995 0.035196488680183 0.779739063699156 0.666666666666667 11.4 11 4 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0186741735442995 0.035196488680183 0.779739063699156 0.666666666666667 11.4 11 4 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.090117229897233 0.139236501784759 0.779739063699156 0.666666666666667 11.4 11 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.090117229897233 0.139236501784759 0.779739063699156 0.666666666666667 11.4 11 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000148459233078413 0.000505932701244261 0.779739063699156 0.666666666666667 11.4 11 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0032329965408245 0.00759167339536842 0.779739063699156 0.666666666666667 11.4 11 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00430723133696094 0.00996616291462671 0.779739063699156 0.666666666666667 11.4 11 4 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0252749591728741 0.0444027986456788 0.779739063699156 0.666666666666667 11.4 11 4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.127147608191556 0.185951743531947 0.779739063699156 0.666666666666667 11.4 11 4 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.127147608191556 0.185951743531947 0.779739063699156 0.666666666666667 11.4 11 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.127147608191556 0.185951743531947 0.779739063699156 0.666666666666667 11.4 11 4 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.127147608191556 0.185951743531947 0.779739063699156 0.666666666666667 11.4 11 4 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.127147608191556 0.185951743531947 0.779739063699156 0.666666666666667 11.4 11 4 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.127147608191556 0.185951743531947 0.779739063699156 0.666666666666667 11.4 11 4 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.1831956010318 0.257850979493819 0.779739063699156 0.666666666666667 11.4 11 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.68459180008944e-38 6.5539676644091e-36 0.772714387449614 0.660660660660661 11.4 11 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.13129311777205e-19 9.05591382841179e-18 0.7726073039702 0.660569105691057 11.4 11 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00849267582077906 0.0177460759074429 0.770230050727215 0.658536585365854 11.4 11 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.000316899323038778 0.00100433794361733 0.769868948968787 0.658227848101266 11.4 11 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0113712667461633 0.0225366470470617 0.769479339176799 0.657894736842105 11.4 11 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0113712667461633 0.0225366470470617 0.769479339176799 0.657894736842105 11.4 11 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0205476630151752 0.0376426557871145 0.767555640828857 0.65625 11.4 11 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00223160485958796 0.00552525640934538 0.766295286738826 0.655172413793103 11.4 11 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00223160485958796 0.00552525640934538 0.766295286738826 0.655172413793103 11.4 11 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00223160485958796 0.00552525640934538 0.766295286738826 0.655172413793103 11.4 11 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 8.81315595202861e-17 2.78691575994149e-15 0.765752712780785 0.654708520179372 11.4 11 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0376498809095677 0.0646269970257116 0.764744081704941 0.653846153846154 11.4 11 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0513288552097505 0.0837625699122418 0.762788214488304 0.652173913043478 11.4 11 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0513288552097505 0.0837625699122418 0.762788214488304 0.652173913043478 11.4 11 4 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0974161834359081 0.146807953921996 0.756805561825651 0.647058823529412 11.4 11 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0974161834359081 0.146807953921996 0.756805561825651 0.647058823529412 11.4 11 4 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0974161834359081 0.146807953921996 0.756805561825651 0.647058823529412 11.4 11 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0974161834359081 0.146807953921996 0.756805561825651 0.647058823529412 11.4 11 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00756305594146992 0.0161838024131003 0.755372217958557 0.645833333333333 11.4 11 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0300872168946885 0.052661881477419 0.754586190676602 0.645161290322581 11.4 11 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0300872168946885 0.052661881477419 0.754586190676602 0.645161290322581 11.4 11 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00164125581926005 0.00426966550421764 0.751891239995615 0.642857142857143 11.4 11 4 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.136246283955218 0.198037244196399 0.751891239995615 0.642857142857143 11.4 11 4 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.136246283955218 0.198037244196399 0.751891239995615 0.642857142857143 11.4 11 4 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.136246283955218 0.198037244196399 0.751891239995615 0.642857142857143 11.4 11 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.136246283955218 0.198037244196399 0.751891239995615 0.642857142857143 11.4 11 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0753330388427207 0.120308629088958 0.744296378985558 0.636363636363636 11.4 11 4 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.193547007856912 0.269488642055172 0.744296378985558 0.636363636363636 11.4 11 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00660029255755724 0.0142306307718242 0.744296378985558 0.636363636363636 11.4 11 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0322687907843619 0.0557263219492075 0.744296378985558 0.636363636363636 11.4 11 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0322687907843619 0.0557263219492075 0.744296378985558 0.636363636363636 11.4 11 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0322687907843619 0.0557263219492075 0.744296378985558 0.636363636363636 11.4 11 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000204215021925191 0.000671126965818816 0.743302658853401 0.635514018691589 11.4 11 4 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00404658638903032 0.00937832643581458 0.742608632094434 0.634920634920635 11.4 11 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 3.64439475921954e-06 1.66751567278759e-05 0.741205447179139 0.633720930232558 11.4 11 4 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.043444212048371 0.0728163883920282 0.740752110514198 0.633333333333333 11.4 11 4 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00704869460152311 0.0151058620752521 0.738700165609727 0.631578947368421 11.4 11 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.103457066763203 0.153995194564894 0.738700165609727 0.631578947368421 11.4 11 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.000486721668480758 0.00147992507317974 0.736853415195702 0.63 11.4 11 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0343054856859844 0.0591717650074615 0.73518254577349 0.628571428571429 11.4 11 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00602854722783024 0.0130971339010724 0.731005372217959 0.625 11.4 11 4 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.143263793329074 0.206131828015442 0.731005372217959 0.625 11.4 11 4 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.281587271356256 0.361641414386239 0.731005372217959 0.625 11.4 11 4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.281587271356256 0.361641414386239 0.731005372217959 0.625 11.4 11 4 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.281587271356256 0.361641414386239 0.731005372217959 0.625 11.4 11 4 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.281587271356256 0.361641414386239 0.731005372217959 0.625 11.4 11 4 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.281587271356256 0.361641414386239 0.731005372217959 0.625 11.4 11 4 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.281587271356256 0.361641414386239 0.731005372217959 0.625 11.4 11 4 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.281587271356256 0.361641414386239 0.731005372217959 0.625 11.4 11 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0362030553587442 0.0623691861688778 0.727053991827591 0.621621621621622 11.4 11 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0618027681610598 0.0999378853331683 0.725963955857835 0.620689655172414 11.4 11 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0286101217649553 0.0502000040339474 0.724043416292073 0.619047619047619 11.4 11 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.108480722238848 0.161304146024954 0.724043416292073 0.619047619047619 11.4 11 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0137040215170982 0.0270469107057292 0.723030768157399 0.618181818181818 11.4 11 4 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0833044689346477 0.129412946827515 0.719759135722298 0.615384615384615 11.4 11 4 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.200591077219853 0.278751077035011 0.719759135722298 0.615384615384615 11.4 11 4 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.200591077219853 0.278751077035011 0.719759135722298 0.615384615384615 11.4 11 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000360786614458036 0.00112835022499733 0.718342287029931 0.614173228346457 11.4 11 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00280495151728124 0.00666351587494357 0.717714365450359 0.613636363636364 11.4 11 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00226116354002909 0.00558617312059271 0.716856881142772 0.612903225806452 11.4 11 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0237286253586807 0.0419973058276153 0.716086895233919 0.612244897959184 11.4 11 4 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.148729021439188 0.213563468726503 0.714760808390893 0.611111111111111 11.4 11 4 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.148729021439188 0.213563468726503 0.714760808390893 0.611111111111111 11.4 11 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 3.46020612849344e-06 1.58834623253102e-05 0.712808671965323 0.609442060085837 11.4 11 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.00956726732857048 0.0197339424765954 0.711935666855751 0.608695652173913 11.4 11 4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.112672880049563 0.167362743539174 0.711935666855751 0.608695652173913 11.4 11 4 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0865311354014742 0.134132685921893 0.710119504440303 0.607142857142857 11.4 11 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0865311354014742 0.134132685921893 0.710119504440303 0.607142857142857 11.4 11 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00550213790791157 0.0120085003726352 0.70176515732924 0.6 11.4 11 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0893406023300935 0.138336971834301 0.70176515732924 0.6 11.4 11 4 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.205439865042194 0.28464438670185 0.70176515732924 0.6 11.4 11 4 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.116178344237516 0.171317910725373 0.70176515732924 0.6 11.4 11 4 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.153007691834848 0.219044210745462 0.70176515732924 0.6 11.4 11 4 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.153007691834848 0.219044210745462 0.70176515732924 0.6 11.4 11 4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.153007691834848 0.219044210745462 0.70176515732924 0.6 11.4 11 4 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.285227458540087 0.362910180788359 0.70176515732924 0.6 11.4 11 4 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.285227458540087 0.362910180788359 0.70176515732924 0.6 11.4 11 4 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.285227458540087 0.362910180788359 0.70176515732924 0.6 11.4 11 4 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.285227458540087 0.362910180788359 0.70176515732924 0.6 11.4 11 4 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.285227458540087 0.362910180788359 0.70176515732924 0.6 11.4 11 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00155071242584793 0.00404892437060844 0.699847766188996 0.598360655737705 11.4 11 4 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.156360709366588 0.223619386360457 0.691132351915161 0.590909090909091 11.4 11 4 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.20876037889074 0.28464438670185 0.688005056205138 0.588235294117647 11.4 11 4 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.286506167388409 0.363367447587974 0.682271680736761 0.583333333333333 11.4 11 4 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.286506167388409 0.363367447587974 0.682271680736761 0.583333333333333 11.4 11 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0481440918497494 0.078927468550914 0.680499546501081 0.581818181818182 11.4 11 4 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.123606807190944 0.182083319495563 0.679127571608942 0.580645161290323 11.4 11 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0205236398372749 0.0376426557871145 0.67866177766408 0.580246913580247 11.4 11 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000578230058635419 0.00173225552302779 0.67682933955612 0.578680203045685 11.4 11 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0773955617360173 0.121026246538849 0.675773855205935 0.577777777777778 11.4 11 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.125302674307541 0.18439059518059 0.673411009558362 0.575757575757576 11.4 11 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0505578442047776 0.0827891971270409 0.671086899085339 0.573770491803279 11.4 11 4 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.286384134906034 0.363367447587974 0.668347768884991 0.571428571428571 11.4 11 4 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.127839121462872 0.186771118933949 0.663831905581714 0.567567567567568 11.4 11 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00496740416191281 0.011273709924086 0.661083119223197 0.565217391304348 11.4 11 4 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.21315488747872 0.285342807979509 0.661083119223197 0.565217391304348 11.4 11 4 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.285380528673348 0.362910180788359 0.657904834996163 0.5625 11.4 11 4 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.285380528673348 0.362910180788359 0.657904834996163 0.5625 11.4 11 4 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.285380528673348 0.362910180788359 0.657904834996163 0.5625 11.4 11 4 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.285380528673348 0.362910180788359 0.657904834996163 0.5625 11.4 11 4 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.285380528673348 0.362910180788359 0.657904834996163 0.5625 11.4 11 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00625548831690341 0.0135487973743585 0.657002359227992 0.561728395061728 11.4 11 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00758733853752452 0.0162113854938399 0.656489985888644 0.561290322580645 11.4 11 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.21337513109499 0.285369183785874 0.64978255308263 0.555555555555556 11.4 11 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.283799575705181 0.362910180788359 0.64978255308263 0.555555555555556 11.4 11 4 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.404576859261828 0.503685801163238 0.64978255308263 0.555555555555556 11.4 11 4 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.404576859261828 0.503685801163238 0.64978255308263 0.555555555555556 11.4 11 4 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.404576859261828 0.503685801163238 0.64978255308263 0.555555555555556 11.4 11 4 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.404576859261828 0.503685801163238 0.64978255308263 0.555555555555556 11.4 11 4 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.404576859261828 0.503685801163238 0.64978255308263 0.555555555555556 11.4 11 4 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.404576859261828 0.503685801163238 0.64978255308263 0.555555555555556 11.4 11 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00189135282534608 0.00484936048732878 0.648216811990864 0.55421686746988 11.4 11 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0119106921320199 0.0235728997272105 0.645796157051448 0.552147239263804 11.4 11 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.212384494205814 0.28464438670185 0.641398262075112 0.548387096774194 11.4 11 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.13084846138664 0.190971651849425 0.639974514545534 0.547169811320755 11.4 11 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0176852552811871 0.0337342471772159 0.639974514545533 0.547169811320755 11.4 11 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0176852552811871 0.0337342471772159 0.639974514545533 0.547169811320755 11.4 11 4 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.395243999359897 0.494663334291235 0.637968324844764 0.545454545454545 11.4 11 4 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.395243999359897 0.494663334291235 0.637968324844764 0.545454545454545 11.4 11 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.395243999359897 0.494663334291235 0.637968324844764 0.545454545454545 11.4 11 4 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.395243999359897 0.494663334291235 0.637968324844764 0.545454545454545 11.4 11 4 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.21157740574074 0.28464438670185 0.637968324844764 0.545454545454545 11.4 11 4 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.277180705202712 0.35824536194683 0.633537989255564 0.541666666666667 11.4 11 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.274640765032856 0.355285280583413 0.62978924375701 0.538461538461538 11.4 11 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.386740439251724 0.485729607286146 0.62978924375701 0.538461538461538 11.4 11 4 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.386740439251724 0.485729607286146 0.62978924375701 0.538461538461538 11.4 11 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.207050216026859 0.28464438670185 0.627594856148101 0.536585365853659 11.4 11 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.272017663112092 0.354246614492359 0.626576033329679 0.535714285714286 11.4 11 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.269341040182158 0.352596412308382 0.623791250959325 0.533333333333333 11.4 11 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0542816731965118 0.0884797490935124 0.623222098358084 0.532846715328467 11.4 11 4 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.266632664806755 0.349372267053419 0.621354566385265 0.53125 11.4 11 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0645195098923869 0.103976514809588 0.619204550584624 0.529411764705882 11.4 11 4 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.26390871607132 0.346121753888929 0.619204550584624 0.529411764705882 11.4 11 4 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.371578197178782 0.467511737033958 0.619204550584624 0.529411764705882 11.4 11 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0163261283306179 0.0316513359870153 0.619204550584624 0.529411764705882 11.4 11 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0639191867530233 0.103125853457542 0.618221686218616 0.528571428571429 11.4 11 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0636123550885296 0.102747311340497 0.61775101877574 0.528169014084507 11.4 11 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.364712483023529 0.459279525081843 0.615583471341439 0.526315789473684 11.4 11 4 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.364712483023529 0.459279525081843 0.615583471341439 0.526315789473684 11.4 11 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0758598828478178 0.120308629088958 0.61468480933948 0.525547445255474 11.4 11 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.191984916391123 0.269488642055172 0.613565164878024 0.524590163934426 11.4 11 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.358229383751868 0.451915259821727 0.612652121477908 0.523809523809524 11.4 11 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.346219045647633 0.437151465799984 0.608196469685341 0.52 11.4 11 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.237458057092355 0.316982003041671 0.606463716210455 0.518518518518518 11.4 11 4 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.335251807118025 0.423782632174456 0.604969963214862 0.517241379310345 11.4 11 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.0749644595786819 0.120128858086109 0.603668952541282 0.516129032258065 11.4 11 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.325128877564397 0.411617787165602 0.602525640131166 0.515151515151515 11.4 11 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.426975875522913 0.520675279014926 0.584804297774367 0.5 11.4 11 4 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.472403215113216 0.551008012382054 0.584804297774367 0.5 11.4 11 4 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.487096743597413 0.565827482562546 0.584804297774367 0.5 11.4 11 4 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.487096743597413 0.565827482562546 0.584804297774367 0.5 11.4 11 4 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.487096743597413 0.565827482562546 0.584804297774367 0.5 11.4 11 4 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.487096743597413 0.565827482562546 0.584804297774367 0.5 11.4 11 4 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.487096743597413 0.565827482562546 0.584804297774367 0.5 11.4 11 4 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.503981831331386 0.584964230003721 0.584804297774367 0.5 11.4 11 4 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.523926259983569 0.606629021933782 0.584804297774367 0.5 11.4 11 4 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.523926259983569 0.606629021933782 0.584804297774367 0.5 11.4 11 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.335333270434601 0.423782632174456 0.576567617524024 0.492957746478873 11.4 11 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.21937400833492 0.29311663273295 0.575320984837485 0.491891891891892 11.4 11 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.306084660789317 0.387852602229028 0.573558061278706 0.490384615384615 11.4 11 4 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.528835434638748 0.611815303651169 0.556956474070826 0.476190476190476 11.4 11 4 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.581776006338527 0.667096903319681 0.545817344589409 0.466666666666667 11.4 11 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.515893115832327 0.598301470113611 0.542601925770031 0.463917525773196 11.4 11 4 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.604474453113954 0.692566140725568 0.539819351791723 0.461538461538462 11.4 11 4 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.605479753038779 0.693159845996928 0.53164027070397 0.454545454545455 11.4 11 4 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.631161477169961 0.708873545392939 0.53164027070397 0.454545454545455 11.4 11 4 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.631161477169961 0.708873545392939 0.53164027070397 0.454545454545455 11.4 11 4 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.631161477169961 0.708873545392939 0.53164027070397 0.454545454545455 11.4 11 4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.631161477169961 0.708873545392939 0.53164027070397 0.454545454545455 11.4 11 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.758765975185083 0.827290200313428 0.530602923834304 0.453658536585366 11.4 11 4 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.623853117466683 0.706106251250956 0.52632386799693 0.45 11.4 11 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.685606865264515 0.767599189041231 0.520618460213766 0.445121951219512 11.4 11 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.665570457930258 0.745753355617919 0.519826042466104 0.444444444444444 11.4 11 4 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.657212710059645 0.737550225879238 0.514627782041443 0.44 11.4 11 4 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.692507735251359 0.772892946872694 0.501260826663743 0.428571428571429 11.4 11 4 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.692507735251359 0.772892946872694 0.501260826663743 0.428571428571429 11.4 11 4 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.692507735251359 0.772892946872694 0.501260826663743 0.428571428571429 11.4 11 4 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.692507735251359 0.772892946872694 0.501260826663743 0.428571428571429 11.4 11 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.724004678016055 0.792506659089882 0.501260826663743 0.428571428571429 11.4 11 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.846310649083964 0.907535835453264 0.487336914811972 0.416666666666667 11.4 11 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.822608537371639 0.89016878226604 0.472820496072892 0.404255319148936 11.4 11 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.860876270999533 0.918999950211804 0.4634298208778 0.39622641509434 11.4 11 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.90978311015814 0.96254376636062 0.458960334962161 0.392405063291139 11.4 11 4 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.801343180635485 0.867816853914989 0.454847787157841 0.388888888888889 11.4 11 4 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.842569822005475 0.905037512929391 0.452751714405961 0.387096774193548 11.4 11 4 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.842569822005475 0.905037512929391 0.452751714405961 0.387096774193548 11.4 11 4 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.795460098981881 0.864971757171411 0.449849459826436 0.384615384615385 11.4 11 4 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.955280581061203 0.997332550880479 0.441852136096188 0.377777777777778 11.4 11 4 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.907781095473434 0.961140252127006 0.435203198343715 0.372093023255814 11.4 11 4 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.891780487657858 0.947017637266516 0.434426049775244 0.371428571428571 11.4 11 4 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.891780487657858 0.947017637266516 0.434426049775244 0.371428571428571 11.4 11 4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.850768584114441 0.909574526818069 0.430908429939007 0.368421052631579 11.4 11 4 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.852655856609948 0.910907870837805 0.417717355553119 0.357142857142857 11.4 11 4 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.91512065043385 0.962923570644871 0.415022404872131 0.354838709677419 11.4 11 4 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.889706963535781 0.946227958977142 0.409363008442057 0.35 11.4 11 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999928562515523 1 0.393462799424228 0.336405529953917 11.4 11 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999842205904 1 0.391879168611689 0.335051546391753 11.4 11 4 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.895819340984966 0.949181624885783 0.389869531849578 0.333333333333333 11.4 11 4 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.895819340984966 0.949181624885783 0.389869531849578 0.333333333333333 11.4 11 4 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.895819340984966 0.949181624885783 0.389869531849578 0.333333333333333 11.4 11 4 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.94871760797865 0.995593772974645 0.374274750575595 0.32 11.4 11 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.99999963600456 1 0.371768446442276 0.317857142857143 11.4 11 4 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.994528980260542 1 0.341135840368381 0.291666666666667 11.4 11 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.994528980260542 1 0.341135840368381 0.291666666666667 11.4 11 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999998896078191 1 0.338920672573781 0.289772727272727 11.4 11 4 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.989994163436076 1 0.338570909237791 0.289473684210526 11.4 11 4 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.978688523288827 1 0.318984162422382 0.272727272727273 11.4 11 4 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.978688523288827 1 0.318984162422382 0.272727272727273 11.4 11 4 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.985607254771748 1 0.305115285795322 0.260869565217391 11.4 11 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.285773384806618 0.244332493702771 11.4 11 4 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.998157474452093 1 0.264105166736811 0.225806451612903 11.4 11 4 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.999759165568545 1 0.250630413331872 0.214285714285714 11.4 11 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.247457876454253 0.211573236889693 11.4 11 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.999267219220905 1 0.233921719109747 0.2 11.4 11 4 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999999805964848 1 0.149311735601966 0.127659574468085 11.4 11 4 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0358428440571386 0.0306451612903226 11.4 11 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.000235293027816975 0.000686110611851547 1.84096809312453 1 12.1 12 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.000235293027816975 0.000686110611851547 1.84096809312453 1 12.1 12 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.000235293027816975 0.000686110611851547 1.84096809312453 1 12.1 12 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.000235293027816975 0.000686110611851547 1.84096809312453 1 12.1 12 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.000235293027816975 0.000686110611851547 1.84096809312453 1 12.1 12 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 1.56865940418467e-07 7.44067444051596e-07 1.84096809312453 1 12.1 12 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 1.56865940418467e-07 7.44067444051596e-07 1.84096809312453 1 12.1 12 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 1.56865940418467e-07 7.44067444051596e-07 1.84096809312453 1 12.1 12 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 4.45990109800472e-07 2.00836685520909e-06 1.84096809312453 1 12.1 12 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 1.26793851554693e-06 5.41824777064048e-06 1.84096809312453 1 12.1 12 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 1.02464476508503e-05 3.72907800694627e-05 1.84096809312453 1 12.1 12 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 1.02464476508503e-05 3.72907800694627e-05 1.84096809312453 1 12.1 12 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 1.02464476508503e-05 3.72907800694627e-05 1.84096809312453 1 12.1 12 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 1.02464476508503e-05 3.72907800694627e-05 1.84096809312453 1 12.1 12 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 2.91256412397063e-05 9.93903776597171e-05 1.84096809312453 1 12.1 12 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 2.91256412397063e-05 9.93903776597171e-05 1.84096809312453 1 12.1 12 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 8.27854611669996e-05 0.000265799939382227 1.84096809312453 1 12.1 12 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 8.27854611669996e-05 0.000265799939382227 1.84096809312453 1 12.1 12 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 8.27854611669996e-05 0.000265799939382227 1.84096809312453 1 12.1 12 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 8.27854611669996e-05 0.000265799939382227 1.84096809312453 1 12.1 12 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000668714062717305 0.0018194648398599 1.84096809312453 1 12.1 12 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000668714062717305 0.0018194648398599 1.84096809312453 1 12.1 12 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.000668714062717305 0.0018194648398599 1.84096809312453 1 12.1 12 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.000668714062717305 0.0018194648398599 1.84096809312453 1 12.1 12 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00190041420856687 0.00481190288041042 1.84096809312453 1 12.1 12 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00190041420856687 0.00481190288041042 1.84096809312453 1 12.1 12 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00190041420856687 0.00481190288041042 1.84096809312453 1 12.1 12 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00190041420856687 0.00481190288041042 1.84096809312453 1 12.1 12 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00190041420856687 0.00481190288041042 1.84096809312453 1 12.1 12 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00190041420856687 0.00481190288041042 1.84096809312453 1 12.1 12 1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.00190041420856687 0.00481190288041042 1.84096809312453 1 12.1 12 1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.00540048169741786 0.0124350897336984 1.84096809312453 1 12.1 12 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 5.8357007556865e-10 3.5488043484367e-09 1.76426108924434 0.958333333333333 12.1 12 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.17847233112889e-08 6.40063407326872e-08 1.75330294583288 0.952380952380952 12.1 12 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 6.2745686483876e-07 2.78152996469021e-06 1.7326758523525 0.941176470588235 12.1 12 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 1.68229457362168e-06 7.02024978962945e-06 1.72590758730425 0.9375 12.1 12 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 1.68229457362168e-06 7.02024978962945e-06 1.72590758730425 0.9375 12.1 12 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 1.68229457362168e-06 7.02024978962945e-06 1.72590758730425 0.9375 12.1 12 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.86664122646154e-17 8.65653808156847e-16 1.72345949143573 0.936170212765957 12.1 12 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.15332176194113e-33 9.11764926245683e-32 1.71079863199451 0.929292929292929 12.1 12 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 6.47475601235197e-15 8.35438572647675e-14 1.70947037218706 0.928571428571429 12.1 12 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 1.19532677902509e-05 4.29532829937553e-05 1.70947037218706 0.928571428571429 12.1 12 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 1.19532677902509e-05 4.29532829937553e-05 1.70947037218706 0.928571428571429 12.1 12 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.83976516852381e-09 1.08630117626945e-08 1.69935516288418 0.923076923076923 12.1 12 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 3.16435107374e-05 0.000106956569547079 1.69935516288418 0.923076923076923 12.1 12 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 4.83913344886105e-09 2.77664794263277e-08 1.69369064567457 0.92 12.1 12 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 1.2687236352489e-08 6.83861262484538e-08 1.68755408536415 0.916666666666667 12.1 12 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 8.33076408745419e-05 0.000265799939382227 1.68755408536415 0.916666666666667 12.1 12 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 8.33076408745419e-05 0.000265799939382227 1.68755408536415 0.916666666666667 12.1 12 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 8.33076408745419e-05 0.000265799939382227 1.68755408536415 0.916666666666667 12.1 12 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 8.33076408745419e-05 0.000265799939382227 1.68755408536415 0.916666666666667 12.1 12 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.18456609733976e-34 1.82861032736146e-32 1.68612030959069 0.91588785046729 12.1 12 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 8.6270961021613e-08 4.26262421992206e-07 1.67360735738594 0.909090909090909 12.1 12 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.000217917577128267 0.000643354174799841 1.67360735738594 0.909090909090909 12.1 12 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 9.88380850918856e-11 6.63427335310156e-10 1.6683773343941 0.90625 12.1 12 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 2.23603790338056e-07 1.03307855081511e-06 1.66563779854124 0.904761904761905 12.1 12 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 2.23603790338056e-07 1.03307855081511e-06 1.66563779854124 0.904761904761905 12.1 12 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 2.23603790338056e-07 1.03307855081511e-06 1.66563779854124 0.904761904761905 12.1 12 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 5.7691812611162e-07 2.57352505785842e-06 1.65687128381208 0.9 12.1 12 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 5.7691812611162e-07 2.57352505785842e-06 1.65687128381208 0.9 12.1 12 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 5.7691812611162e-07 2.57352505785842e-06 1.65687128381208 0.9 12.1 12 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.000565723840512639 0.0015541023649604 1.65687128381208 0.9 12.1 12 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.000565723840512639 0.0015541023649604 1.65687128381208 0.9 12.1 12 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000565723840512639 0.0015541023649604 1.65687128381208 0.9 12.1 12 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.000565723840512639 0.0015541023649604 1.65687128381208 0.9 12.1 12 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.000565723840512639 0.0015541023649604 1.65687128381208 0.9 12.1 12 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 4.31203338029048e-09 2.4943184959973e-08 1.64372151171833 0.892857142857143 12.1 12 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00145535356101677 0.00375175383573708 1.63641608277736 0.888888888888889 12.1 12 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00145535356101677 0.00375175383573708 1.63641608277736 0.888888888888889 12.1 12 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00145535356101677 0.00375175383573708 1.63641608277736 0.888888888888889 12.1 12 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00145535356101677 0.00375175383573708 1.63641608277736 0.888888888888889 12.1 12 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00145535356101677 0.00375175383573708 1.63641608277736 0.888888888888889 12.1 12 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 3.83392352931269e-48 6.06185909134662e-46 1.63521283565767 0.888235294117647 12.1 12 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 9.7536359756851e-48 1.38794239933999e-45 1.6339953489271 0.887573964497041 12.1 12 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 8.47808554670222e-11 5.77239987222836e-10 1.63057173962458 0.885714285714286 12.1 12 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.5997101993207e-45 3.36307964875759e-43 1.62637672030633 0.883435582822086 12.1 12 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.14137968129061e-10 1.39140789336828e-09 1.62438361158047 0.882352941176471 12.1 12 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 9.59357738949357e-06 3.55511995449202e-05 1.62438361158047 0.882352941176471 12.1 12 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 9.59357738949357e-06 3.55511995449202e-05 1.62438361158047 0.882352941176471 12.1 12 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 9.59357738949357e-06 3.55511995449202e-05 1.62438361158047 0.882352941176471 12.1 12 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 7.02399909790935e-08 3.4826309116115e-07 1.62005192194959 0.88 12.1 12 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 7.02399909790935e-08 3.4826309116115e-07 1.62005192194959 0.88 12.1 12 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 5.38865816575253e-10 3.31950674020167e-09 1.61782044547307 0.878787878787879 12.1 12 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.24256169266292e-12 3.26333258846451e-11 1.61645978908495 0.878048780487805 12.1 12 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.24256169266292e-12 3.26333258846451e-11 1.61645978908495 0.878048780487805 12.1 12 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 2.41737658338366e-05 8.28898042928902e-05 1.61084708148396 0.875 12.1 12 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 2.41737658338366e-05 8.28898042928902e-05 1.61084708148396 0.875 12.1 12 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 2.41737658338366e-05 8.28898042928902e-05 1.61084708148396 0.875 12.1 12 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 2.41737658338366e-05 8.28898042928902e-05 1.61084708148396 0.875 12.1 12 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00370266130701962 0.00885527233594777 1.61084708148396 0.875 12.1 12 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00370266130701962 0.00885527233594777 1.61084708148396 0.875 12.1 12 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00370266130701962 0.00885527233594777 1.61084708148396 0.875 12.1 12 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00370266130701962 0.00885527233594777 1.61084708148396 0.875 12.1 12 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00370266130701962 0.00885527233594777 1.61084708148396 0.875 12.1 12 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00370266130701962 0.00885527233594777 1.61084708148396 0.875 12.1 12 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.76364952949962e-07 8.25550421209857e-07 1.61084708148396 0.875 12.1 12 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.84822363535e-19 9.00671607356233e-18 1.60427219543709 0.871428571428571 12.1 12 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 3.3714579180041e-09 1.97431465733327e-08 1.60342382304394 0.870967741935484 12.1 12 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 8.37793837245338e-09 4.60301401698886e-08 1.59550568070793 0.866666666666667 12.1 12 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 8.37793837245338e-09 4.60301401698886e-08 1.59550568070793 0.866666666666667 12.1 12 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 8.37793837245338e-09 4.60301401698886e-08 1.59550568070793 0.866666666666667 12.1 12 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 6.04402732994162e-05 0.000198629350820021 1.59550568070793 0.866666666666667 12.1 12 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.62291820098265e-14 2.91594734374868e-13 1.59314546520392 0.865384615384615 12.1 12 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 2.62291820098265e-14 2.91594734374868e-13 1.59314546520392 0.865384615384615 12.1 12 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.62291820098265e-14 2.91594734374868e-13 1.59314546520392 0.865384615384615 12.1 12 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.63341711084351e-10 1.07113020678817e-09 1.59218862108067 0.864864864864865 12.1 12 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 1.09337837600886e-06 4.68637779837534e-06 1.58992698951664 0.863636363636364 12.1 12 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 2.07196941674649e-08 1.09606411897036e-07 1.58704145959011 0.862068965517241 12.1 12 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.03037752466723e-10 2.57185077022488e-09 1.58527808019057 0.861111111111111 12.1 12 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 7.97009496009927e-12 5.87639643949288e-11 1.58408882431646 0.86046511627907 12.1 12 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.35719929834501e-21 5.08235421459198e-20 1.5779726512496 0.857142857142857 12.1 12 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.35719929834501e-21 5.08235421459198e-20 1.5779726512496 0.857142857142857 12.1 12 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.95657512464549e-11 1.39210320118527e-10 1.5779726512496 0.857142857142857 12.1 12 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 9.90280644101296e-10 5.89610609437717e-09 1.5779726512496 0.857142857142857 12.1 12 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.696804140753e-06 1.08712529526672e-05 1.5779726512496 0.857142857142857 12.1 12 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.696804140753e-06 1.08712529526672e-05 1.5779726512496 0.857142857142857 12.1 12 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.59632180282867e-16 2.6413557272386e-15 1.5779726512496 0.857142857142857 12.1 12 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 3.91022349361828e-13 3.29245445646083e-12 1.5779726512496 0.857142857142857 12.1 12 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000149784968420295 0.000461350671130044 1.5779726512496 0.857142857142857 12.1 12 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000149784968420295 0.000461350671130044 1.5779726512496 0.857142857142857 12.1 12 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.000149784968420295 0.000461350671130044 1.5779726512496 0.857142857142857 12.1 12 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.000149784968420295 0.000461350671130044 1.5779726512496 0.857142857142857 12.1 12 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.000149784968420295 0.000461350671130044 1.5779726512496 0.857142857142857 12.1 12 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.000149784968420295 0.000461350671130044 1.5779726512496 0.857142857142857 12.1 12 1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.00929061508366425 0.020402076024775 1.5779726512496 0.857142857142857 12.1 12 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00929061508366425 0.020402076024775 1.5779726512496 0.857142857142857 12.1 12 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00929061508366425 0.020402076024775 1.5779726512496 0.857142857142857 12.1 12 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00929061508366425 0.020402076024775 1.5779726512496 0.857142857142857 12.1 12 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00929061508366425 0.020402076024775 1.5779726512496 0.857142857142857 12.1 12 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 6.44523420426037e-72 1.8343136545325e-69 1.57707505588484 0.856655290102389 12.1 12 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 9.5235490715164e-16 1.3417832008681e-14 1.56934984987665 0.852459016393443 12.1 12 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.24752045126139e-07 6.01770034625409e-07 1.5682320793283 0.851851851851852 12.1 12 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.54336409662316e-62 3.66034518249127e-60 1.56588090679558 0.850574712643678 12.1 12 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 6.60447728750053e-06 2.53319977900627e-05 1.56482287915585 0.85 12.1 12 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 6.60447728750053e-06 2.53319977900627e-05 1.56482287915585 0.85 12.1 12 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 5.65954678516642e-12 4.32985756736119e-11 1.56082077460558 0.847826086956522 12.1 12 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.68261876933252e-18 1.09275223091354e-16 1.55970907889717 0.847222222222222 12.1 12 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.000367460356628822 0.00104162567227652 1.55774223264383 0.846153846153846 12.1 12 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000367460356628822 0.00104162567227652 1.55774223264383 0.846153846153846 12.1 12 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000367460356628822 0.00104162567227652 1.55774223264383 0.846153846153846 12.1 12 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000367460356628822 0.00104162567227652 1.55774223264383 0.846153846153846 12.1 12 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.35889016614114e-14 1.68147887514682e-13 1.55530063039831 0.844827586206897 12.1 12 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.35889016614114e-14 1.68147887514682e-13 1.55530063039831 0.844827586206897 12.1 12 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 3.60152176866929e-26 1.76722947476428e-24 1.55384462905924 0.844036697247706 12.1 12 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 1.60479060348572e-05 5.69480555800544e-05 1.55028892052592 0.842105263157895 12.1 12 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.09066304855737e-25 9.91671172699046e-24 1.54847783533839 0.841121495327103 12.1 12 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 7.97359843261607e-17 1.40079389748305e-15 1.54748042610468 0.840579710144927 12.1 12 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 7.33521003297029e-07 3.18231825515754e-06 1.5464131982246 0.84 12.1 12 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 7.33521003297029e-07 3.18231825515754e-06 1.5464131982246 0.84 12.1 12 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 7.33521003297029e-07 3.18231825515754e-06 1.5464131982246 0.84 12.1 12 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.69922673925223e-19 1.39312492707415e-17 1.54181077799179 0.8375 12.1 12 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.88595409965581e-13 1.63641017305501e-12 1.53971876879506 0.836363636363636 12.1 12 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.88595409965581e-13 1.63641017305501e-12 1.53971876879506 0.836363636363636 12.1 12 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.88595409965581e-13 1.63641017305501e-12 1.53971876879506 0.836363636363636 12.1 12 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.88595409965581e-13 1.63641017305501e-12 1.53971876879506 0.836363636363636 12.1 12 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.70422438339083e-94 1.75703709918838e-91 1.53414007760377 0.833333333333333 12.1 12 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.21312835914369e-14 2.53974327021086e-13 1.53414007760377 0.833333333333333 12.1 12 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.21312835914369e-14 2.53974327021086e-13 1.53414007760377 0.833333333333333 12.1 12 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.21312835914369e-14 2.53974327021086e-13 1.53414007760377 0.833333333333333 12.1 12 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.21312835914369e-14 2.53974327021086e-13 1.53414007760377 0.833333333333333 12.1 12 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.21312835914369e-14 2.53974327021086e-13 1.53414007760377 0.833333333333333 12.1 12 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.21312835914369e-14 2.53974327021086e-13 1.53414007760377 0.833333333333333 12.1 12 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.21312835914369e-14 2.53974327021086e-13 1.53414007760377 0.833333333333333 12.1 12 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 9.2018478327688e-12 6.71498946975897e-11 1.53414007760377 0.833333333333333 12.1 12 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 9.2018478327688e-12 6.71498946975897e-11 1.53414007760377 0.833333333333333 12.1 12 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 1.76076140515746e-06 7.28361476610192e-06 1.53414007760377 0.833333333333333 12.1 12 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 1.76076140515746e-06 7.28361476610192e-06 1.53414007760377 0.833333333333333 12.1 12 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 3.86560564133584e-05 0.000128222769874613 1.53414007760377 0.833333333333333 12.1 12 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 3.86560564133584e-05 0.000128222769874613 1.53414007760377 0.833333333333333 12.1 12 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 3.86560564133584e-05 0.000128222769874613 1.53414007760377 0.833333333333333 12.1 12 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 3.86560564133584e-05 0.000128222769874613 1.53414007760377 0.833333333333333 12.1 12 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000890967258396892 0.00236098027690647 1.53414007760377 0.833333333333333 12.1 12 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.000890967258396892 0.00236098027690647 1.53414007760377 0.833333333333333 12.1 12 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000890967258396892 0.00236098027690647 1.53414007760377 0.833333333333333 12.1 12 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.000890967258396892 0.00236098027690647 1.53414007760377 0.833333333333333 12.1 12 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000890967258396892 0.00236098027690647 1.53414007760377 0.833333333333333 12.1 12 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0229008191416728 0.0453238743235055 1.53414007760377 0.833333333333333 12.1 12 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 6.62415584738007e-21 2.35654344270546e-19 1.53414007760377 0.833333333333333 12.1 12 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 4.50194967281841e-13 3.66072821966892e-12 1.53414007760377 0.833333333333333 12.1 12 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 4.50194967281841e-13 3.66072821966892e-12 1.53414007760377 0.833333333333333 12.1 12 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 4.86418376343867e-27 2.56360499828638e-25 1.53156169091873 0.831932773109244 12.1 12 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.28542625576155e-16 2.17757328803414e-15 1.52981855625841 0.830985915492958 12.1 12 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.07082600916227e-12 8.60895712450798e-12 1.52835086976376 0.830188679245283 12.1 12 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 9.29967482824557e-23 3.78098208016956e-21 1.52800351729336 0.83 12.1 12 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.18885891219445e-11 1.549624991071e-10 1.5276118219544 0.829787234042553 12.1 12 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 4.50290524521496e-10 2.78592789736561e-09 1.52665646746912 0.829268292682927 12.1 12 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 4.50290524521496e-10 2.78592789736561e-09 1.52665646746912 0.829268292682927 12.1 12 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 4.50290524521496e-10 2.78592789736561e-09 1.52665646746912 0.829268292682927 12.1 12 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 4.50290524521496e-10 2.78592789736561e-09 1.52665646746912 0.829268292682927 12.1 12 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 6.15977376467847e-15 8.04161290563069e-14 1.52455170211875 0.828125 12.1 12 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.84560393922671e-28 2.2801226689665e-26 1.52206023447304 0.826771653543307 12.1 12 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 7.21261949599968e-16 1.02635575428076e-14 1.52079972910287 0.826086956521739 12.1 12 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 7.21261949599968e-16 1.02635575428076e-14 1.52079972910287 0.826086956521739 12.1 12 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.4561447594863e-14 1.78628792478363e-13 1.51952921972183 0.825396825396825 12.1 12 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 5.99031183515341e-12 4.51016600075307e-11 1.51609137080844 0.823529411764706 12.1 12 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 5.99031183515341e-12 4.51016600075307e-11 1.51609137080844 0.823529411764706 12.1 12 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 5.99031183515341e-12 4.51016600075307e-11 1.51609137080844 0.823529411764706 12.1 12 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 2.21121289447886e-08 1.15682204001596e-07 1.51609137080844 0.823529411764706 12.1 12 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 2.21121289447886e-08 1.15682204001596e-07 1.51609137080844 0.823529411764706 12.1 12 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 2.21121289447886e-08 1.15682204001596e-07 1.51609137080844 0.823529411764706 12.1 12 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 9.2214645240771e-05 0.000290956630105581 1.51609137080844 0.823529411764706 12.1 12 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 9.2214645240771e-05 0.000290956630105581 1.51609137080844 0.823529411764706 12.1 12 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 9.2214645240771e-05 0.000290956630105581 1.51609137080844 0.823529411764706 12.1 12 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 9.2214645240771e-05 0.000290956630105581 1.51609137080844 0.823529411764706 12.1 12 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 9.2214645240771e-05 0.000290956630105581 1.51609137080844 0.823529411764706 12.1 12 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 9.90558895203754e-18 1.83060429594148e-16 1.51472058295056 0.822784810126582 12.1 12 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.43105124797489e-14 3.72701215715135e-13 1.51434472176373 0.82258064516129 12.1 12 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.98876946340743e-16 3.25289534072273e-15 1.51312446010235 0.821917808219178 12.1 12 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 6.93952398246558e-13 5.61076285627757e-12 1.51222379078086 0.821428571428571 12.1 12 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.99906037280041e-15 5.26913232453239e-14 1.51124246450521 0.82089552238806 12.1 12 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.40839849085683e-11 1.01733555963922e-10 1.50959383636211 0.82 12.1 12 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 8.05719633896701e-14 7.74688539888518e-13 1.50899024026601 0.819672131147541 12.1 12 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 8.05719633896701e-14 7.74688539888518e-13 1.50899024026601 0.819672131147541 12.1 12 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.646333199204e-28 1.01857919237708e-26 1.5087633244404 0.819548872180451 12.1 12 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 4.66691445985098e-16 7.06491412379568e-15 1.50857107631038 0.819444444444444 12.1 12 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.66691445985098e-16 7.06491412379568e-15 1.50857107631038 0.819444444444444 12.1 12 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.10633478156795e-23 4.63033645344469e-22 1.50624662164734 0.818181818181818 12.1 12 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.627392975205e-12 1.2865445576204e-11 1.50624662164734 0.818181818181818 12.1 12 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.627392975205e-12 1.2865445576204e-11 1.50624662164734 0.818181818181818 12.1 12 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 9.9122200821016e-06 3.64472588548594e-05 1.50624662164734 0.818181818181818 12.1 12 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 9.9122200821016e-06 3.64472588548594e-05 1.50624662164734 0.818181818181818 12.1 12 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00213085202574232 0.00534779970481713 1.50624662164734 0.818181818181818 12.1 12 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00213085202574232 0.00534779970481713 1.50624662164734 0.818181818181818 12.1 12 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00213085202574232 0.00534779970481713 1.50624662164734 0.818181818181818 12.1 12 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00213085202574232 0.00534779970481713 1.50624662164734 0.818181818181818 12.1 12 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 6.37463553183776e-18 1.20948084824068e-16 1.50420563706516 0.817073170731707 12.1 12 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.88548638173287e-13 1.63641017305501e-12 1.5034572760517 0.816666666666667 12.1 12 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 7.45878510906838e-19 2.08114729611849e-17 1.50239924841197 0.816091954022989 12.1 12 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 7.45878510906838e-19 2.08114729611849e-17 1.50239924841197 0.816091954022989 12.1 12 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.27368689656702e-16 2.17757328803414e-15 1.50184239175948 0.815789473684211 12.1 12 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 5.88678576488286e-09 3.33740882208299e-08 1.50184239175948 0.815789473684211 12.1 12 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.80160259343611e-12 2.95610955762819e-11 1.50004807587925 0.814814814814815 12.1 12 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 1.08983626394719e-06 4.68530816796633e-06 1.50004807587925 0.814814814814815 12.1 12 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 1.08983626394719e-06 4.68530816796633e-06 1.50004807587925 0.814814814814815 12.1 12 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.06924375163725e-106 1.4722669292899e-103 1.49797403775152 0.813688212927757 12.1 12 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.39634127717205e-13 3.61618129330395e-12 1.49773675372843 0.813559322033898 12.1 12 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.39634127717205e-13 3.61618129330395e-12 1.49773675372843 0.813559322033898 12.1 12 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.39634127717205e-13 3.61618129330395e-12 1.49773675372843 0.813559322033898 12.1 12 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.96692339985957e-16 4.79764999772747e-15 1.49732071574128 0.813333333333333 12.1 12 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000217595138983595 0.000643354174799841 1.49578657566368 0.8125 12.1 12 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000217595138983595 0.000643354174799841 1.49578657566368 0.8125 12.1 12 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000217595138983595 0.000643354174799841 1.49578657566368 0.8125 12.1 12 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000217595138983595 0.000643354174799841 1.49578657566368 0.8125 12.1 12 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 6.89047204211406e-16 1.01083935215756e-14 1.49267683226313 0.810810810810811 12.1 12 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 6.89047204211406e-16 1.01083935215756e-14 1.49267683226313 0.810810810810811 12.1 12 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 2.32120881611776e-05 8.05629303740384e-05 1.49030750395795 0.80952380952381 12.1 12 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.53972956853172e-06 1.03554016504889e-05 1.48693576752366 0.807692307692308 12.1 12 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 2.53972956853172e-06 1.03554016504889e-05 1.48693576752366 0.807692307692308 12.1 12 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 2.53972956853172e-06 1.03554016504889e-05 1.48693576752366 0.807692307692308 12.1 12 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2.82498624838079e-07 1.29259017088291e-06 1.48465168800365 0.806451612903226 12.1 12 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 3.68195292442178e-15 4.89665328173102e-14 1.48300207501698 0.805555555555556 12.1 12 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 3.17861644069554e-08 1.62703999824092e-07 1.48300207501698 0.805555555555556 12.1 12 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 3.17861644069554e-08 1.62703999824092e-07 1.48300207501698 0.805555555555556 12.1 12 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.17861644069554e-08 1.62703999824092e-07 1.48300207501698 0.805555555555556 12.1 12 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 3.60674813201872e-09 2.09485820076026e-08 1.48175480666121 0.804878048780488 12.1 12 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.1187406616059e-10 2.60487464954009e-09 1.48077868360016 0.804347826086957 12.1 12 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 4.1187406616059e-10 2.60487464954009e-09 1.48077868360016 0.804347826086957 12.1 12 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.08536285969346e-10 7.25103919879715e-10 1.47277447449962 0.8 12.1 12 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 5.86972301259915e-06 2.26973256710016e-05 1.47277447449962 0.8 12.1 12 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.44397608589288e-12 1.15436964619414e-11 1.47277447449962 0.8 12.1 12 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.24984410663608e-11 9.07412328440378e-11 1.47277447449962 0.8 12.1 12 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 8.29470527350591e-09 4.60301401698886e-08 1.47277447449962 0.8 12.1 12 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 8.29470527350591e-09 4.60301401698886e-08 1.47277447449962 0.8 12.1 12 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 5.38216210242841e-05 0.000178112015622224 1.47277447449962 0.8 12.1 12 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000507163748903811 0.00140681094481506 1.47277447449962 0.8 12.1 12 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000507163748903811 0.00140681094481506 1.47277447449962 0.8 12.1 12 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000507163748903811 0.00140681094481506 1.47277447449962 0.8 12.1 12 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.000507163748903811 0.00140681094481506 1.47277447449962 0.8 12.1 12 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000507163748903811 0.00140681094481506 1.47277447449962 0.8 12.1 12 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000507163748903811 0.00140681094481506 1.47277447449962 0.8 12.1 12 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000507163748903811 0.00140681094481506 1.47277447449962 0.8 12.1 12 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00501387244303332 0.0117734991525353 1.47277447449962 0.8 12.1 12 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00501387244303332 0.0117734991525353 1.47277447449962 0.8 12.1 12 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00501387244303332 0.0117734991525353 1.47277447449962 0.8 12.1 12 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00501387244303332 0.0117734991525353 1.47277447449962 0.8 12.1 12 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00501387244303332 0.0117734991525353 1.47277447449962 0.8 12.1 12 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00501387244303332 0.0117734991525353 1.47277447449962 0.8 12.1 12 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00501387244303332 0.0117734991525353 1.47277447449962 0.8 12.1 12 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00501387244303332 0.0117734991525353 1.47277447449962 0.8 12.1 12 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.11803938931648e-19 3.61584102499398e-18 1.46905534703877 0.797979797979798 12.1 12 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.43671379328473e-14 4.38433592211401e-13 1.46743833509926 0.797101449275362 12.1 12 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.67394535861689e-07 7.86146615614468e-07 1.46194525042242 0.794117647058823 12.1 12 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.49090928003472e-06 6.29544185605163e-06 1.4600781428229 0.793103448275862 12.1 12 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 9.0673151528312e-25 4.03212170702462e-23 1.45861318147559 0.792307692307692 12.1 12 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 1.34445223925987e-05 4.79487603124509e-05 1.45743307372359 0.791666666666667 12.1 12 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 1.34445223925987e-05 4.79487603124509e-05 1.45743307372359 0.791666666666667 12.1 12 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 1.34445223925987e-05 4.79487603124509e-05 1.45743307372359 0.791666666666667 12.1 12 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.2909405563288e-13 1.95210084530292e-12 1.45628819306866 0.791044776119403 12.1 12 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.2909405563288e-13 1.95210084530292e-12 1.45628819306866 0.791044776119403 12.1 12 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.2909405563288e-13 1.95210084530292e-12 1.45628819306866 0.791044776119403 12.1 12 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 9.59957944053057e-17 1.66587823705793e-15 1.45564918991242 0.790697674418605 12.1 12 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 4.91716901348254e-09 2.81009297437175e-08 1.45564918991242 0.790697674418605 12.1 12 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.48376509529699e-19 1.05476547459736e-17 1.45436479356838 0.79 12.1 12 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.77014614164013e-18 4.84407299914212e-17 1.44647493031213 0.785714285714286 12.1 12 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 3.38420676451992e-06 1.34142791808129e-05 1.44647493031213 0.785714285714286 12.1 12 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 3.38420676451992e-06 1.34142791808129e-05 1.44647493031213 0.785714285714286 12.1 12 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 3.38420676451992e-06 1.34142791808129e-05 1.44647493031213 0.785714285714286 12.1 12 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00116560344672675 0.00305461087420288 1.44647493031213 0.785714285714286 12.1 12 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00116560344672675 0.00305461087420288 1.44647493031213 0.785714285714286 12.1 12 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00116560344672675 0.00305461087420288 1.44647493031213 0.785714285714286 12.1 12 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00116560344672675 0.00305461087420288 1.44647493031213 0.785714285714286 12.1 12 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 3.31329891277624e-10 2.12379475354982e-09 1.44389654362708 0.784313725490196 12.1 12 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 9.72779265593046e-08 4.72445356634438e-07 1.44292093785436 0.783783783783784 12.1 12 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 9.72779265593046e-08 4.72445356634438e-07 1.44292093785436 0.783783783783784 12.1 12 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 3.04946505785197e-05 0.000103318780412461 1.44075763809746 0.782608695652174 12.1 12 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.49629973321271e-08 1.29643595633638e-07 1.43685314585329 0.780487804878049 12.1 12 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.49629973321271e-08 1.29643595633638e-07 1.43685314585329 0.780487804878049 12.1 12 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000279669706136714 0.000810529514933898 1.43186407243019 0.777777777777778 12.1 12 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000279669706136714 0.000810529514933898 1.43186407243019 0.777777777777778 12.1 12 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000279669706136714 0.000810529514933898 1.43186407243019 0.777777777777778 12.1 12 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0115682384180296 0.025132218731078 1.43186407243019 0.777777777777778 12.1 12 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0115682384180296 0.025132218731078 1.43186407243019 0.777777777777778 12.1 12 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0115682384180296 0.025132218731078 1.43186407243019 0.777777777777778 12.1 12 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0115682384180296 0.025132218731078 1.43186407243019 0.777777777777778 12.1 12 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0115682384180296 0.025132218731078 1.43186407243019 0.777777777777778 12.1 12 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0115682384180296 0.025132218731078 1.43186407243019 0.777777777777778 12.1 12 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 6.42186160679567e-09 3.61197986817006e-08 1.43186407243019 0.777777777777778 12.1 12 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 7.61435613457751e-06 2.88170978178293e-05 1.43186407243019 0.777777777777778 12.1 12 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 7.61435613457751e-06 2.88170978178293e-05 1.43186407243019 0.777777777777778 12.1 12 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 7.61435613457751e-06 2.88170978178293e-05 1.43186407243019 0.777777777777778 12.1 12 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 7.61435613457751e-06 2.88170978178293e-05 1.43186407243019 0.777777777777778 12.1 12 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.43099078284326e-15 1.93933322284376e-14 1.42945757819081 0.776470588235294 12.1 12 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.43099078284326e-15 1.93933322284376e-14 1.42945757819081 0.776470588235294 12.1 12 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.43099078284326e-15 1.93933322284376e-14 1.42945757819081 0.776470588235294 12.1 12 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.98919641624298e-11 3.42977125619023e-10 1.4283373136311 0.775862068965517 12.1 12 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.98919641624298e-11 3.42977125619023e-10 1.4283373136311 0.775862068965517 12.1 12 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.95541403879769e-13 3.31091422188771e-12 1.42610204396971 0.774647887323944 12.1 12 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 4.2761003347153e-10 2.69242954703534e-09 1.4241451286435 0.773584905660377 12.1 12 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.03122570483366e-13 9.52879336349542e-13 1.4236819920163 0.773333333333333 12.1 12 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.03122570483366e-13 9.52879336349542e-13 1.4236819920163 0.773333333333333 12.1 12 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.03122570483366e-13 9.52879336349542e-13 1.4236819920163 0.773333333333333 12.1 12 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.03122570483366e-13 9.52879336349542e-13 1.4236819920163 0.773333333333333 12.1 12 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.03122570483366e-13 9.52879336349542e-13 1.4236819920163 0.773333333333333 12.1 12 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.42808134377602e-08 7.611085214207e-08 1.42256625377805 0.772727272727273 12.1 12 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 6.84316396300354e-05 0.000223344548609038 1.42256625377805 0.772727272727273 12.1 12 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 6.84316396300354e-05 0.000223344548609038 1.42256625377805 0.772727272727273 12.1 12 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.19633006145964e-31 3.52113222736051e-29 1.41845082585005 0.770491803278688 12.1 12 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 1.69697011594906e-05 5.93314121620521e-05 1.41612930240348 0.769230769230769 12.1 12 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.69697011594906e-05 5.93314121620521e-05 1.41612930240348 0.769230769230769 12.1 12 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 1.69697011594906e-05 5.93314121620521e-05 1.41612930240348 0.769230769230769 12.1 12 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 1.69697011594906e-05 5.93314121620521e-05 1.41612930240348 0.769230769230769 12.1 12 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00263599026429045 0.00648964385135867 1.41612930240348 0.769230769230769 12.1 12 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00263599026429045 0.00648964385135867 1.41612930240348 0.769230769230769 12.1 12 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.00263599026429045 0.00648964385135867 1.41612930240348 0.769230769230769 12.1 12 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 3.15588919509154e-08 1.62703999824092e-07 1.41283597844441 0.767441860465116 12.1 12 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 9.63372545512856e-35 8.56799457665496e-33 1.41140887139547 0.766666666666667 12.1 12 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.63385089342814e-11 1.16832654339108e-10 1.40949119629847 0.765625 12.1 12 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.39482642920085e-14 3.71602923750216e-13 1.4091360712805 0.765432098765432 12.1 12 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.39482642920085e-14 3.71602923750216e-13 1.4091360712805 0.765432098765432 12.1 12 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000625081743647777 0.00171385611023273 1.4077991300364 0.764705882352941 12.1 12 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.27200735355953e-36 7.84737764274347e-34 1.40583018020419 0.763636363636364 12.1 12 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 6.00597151986198e-16 8.99631312922484e-15 1.40547026464346 0.763440860215054 12.1 12 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.85591806247551e-13 2.41903059696587e-12 1.40494933422661 0.763157894736842 12.1 12 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 2.71876886212864e-07 1.2480026099384e-06 1.40494933422661 0.763157894736842 12.1 12 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 2.71876886212864e-07 1.2480026099384e-06 1.40494933422661 0.763157894736842 12.1 12 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.7278896520506e-26 1.38635249102429e-24 1.40373817100745 0.7625 12.1 12 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000151772126186225 0.000466461631885525 1.40264235666631 0.761904761904762 12.1 12 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.27645059987229e-25 1.0449642592317e-23 1.40151119347545 0.761290322580645 12.1 12 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.77212835477359e-08 9.40947257030904e-08 1.40073659259475 0.760869565217391 12.1 12 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 3.74313870959304e-05 0.000125329091382374 1.39913575077464 0.76 12.1 12 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.61799415524518e-13 1.44805388862509e-12 1.39820361503129 0.759493670886076 12.1 12 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.61799415524518e-13 1.44805388862509e-12 1.39820361503129 0.759493670886076 12.1 12 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.61799415524518e-13 1.44805388862509e-12 1.39820361503129 0.759493670886076 12.1 12 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 9.3345702871877e-06 3.48637625161892e-05 1.3965964844393 0.758620689655172 12.1 12 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 9.3345702871877e-06 3.48637625161892e-05 1.3965964844393 0.758620689655172 12.1 12 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.81518669814063e-20 9.31630388710261e-19 1.39557258672343 0.758064516129032 12.1 12 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.81518669814063e-20 9.31630388710261e-19 1.39557258672343 0.758064516129032 12.1 12 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.81518669814063e-20 9.31630388710261e-19 1.39557258672343 0.758064516129032 12.1 12 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 2.34711886040332e-06 9.65303508194777e-06 1.39467279782161 0.757575757575758 12.1 12 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.5105057951132e-07 7.23720453348848e-07 1.39195148504538 0.75609756097561 12.1 12 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.9260892116958e-12 2.28781590562809e-11 1.38703075509382 0.753424657534247 12.1 12 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.12555203909348e-14 5.03011072526208e-13 1.386140681882 0.752941176470588 12.1 12 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00137586957866446 0.00357927314522766 1.3807260698434 0.75 12.1 12 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00137586957866446 0.00357927314522766 1.3807260698434 0.75 12.1 12 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00137586957866446 0.00357927314522766 1.3807260698434 0.75 12.1 12 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0260544764135981 0.0503059972002037 1.3807260698434 0.75 12.1 12 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 8.9794871482738e-18 1.68129081736758e-16 1.3807260698434 0.75 12.1 12 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.26920385736605e-07 1.48628660991434e-06 1.3807260698434 0.75 12.1 12 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 3.26920385736605e-07 1.48628660991434e-06 1.3807260698434 0.75 12.1 12 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.28713622275008e-06 5.48381690111786e-06 1.3807260698434 0.75 12.1 12 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 8.16450351362827e-05 0.000265253162098014 1.3807260698434 0.75 12.1 12 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000332281618258097 0.000951381776219862 1.3807260698434 0.75 12.1 12 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000332281618258097 0.000951381776219862 1.3807260698434 0.75 12.1 12 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000332281618258097 0.000951381776219862 1.3807260698434 0.75 12.1 12 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000332281618258097 0.000951381776219862 1.3807260698434 0.75 12.1 12 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000332281618258097 0.000951381776219862 1.3807260698434 0.75 12.1 12 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0058505063277786 0.0132568001662881 1.3807260698434 0.75 12.1 12 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.32024931528233e-16 2.21025267723147e-15 1.3807260698434 0.75 12.1 12 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 5.48073723113348e-09 3.11963563196118e-08 1.3807260698434 0.75 12.1 12 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.1154285612098e-17 7.41298081341968e-16 1.37235803305647 0.745454545454545 12.1 12 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.76581765448697e-06 1.10866437248872e-05 1.36757629774965 0.742857142857143 12.1 12 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.76581765448697e-06 1.10866437248872e-05 1.36757629774965 0.742857142857143 12.1 12 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 7.13724054235882e-16 1.02635575428076e-14 1.36302445356335 0.740384615384615 12.1 12 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.58950760545426e-11 1.14235824371788e-10 1.36181201409212 0.73972602739726 12.1 12 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 9.7649486486985e-08 4.72636800241427e-07 1.36071554709204 0.739130434782609 12.1 12 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000175919775275997 0.000539512586676171 1.36071554709204 0.739130434782609 12.1 12 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 6.84421503411951e-24 2.95130848289456e-22 1.35827523943944 0.73780487804878 12.1 12 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 6.70266531901229e-124 9.53789274895449e-121 1.35781809583393 0.737556561085973 12.1 12 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000717122346387846 0.00193636641159375 1.35650280546018 0.736842105263158 12.1 12 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000717122346387846 0.00193636641159375 1.35650280546018 0.736842105263158 12.1 12 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000717122346387846 0.00193636641159375 1.35650280546018 0.736842105263158 12.1 12 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000717122346387846 0.00193636641159375 1.35650280546018 0.736842105263158 12.1 12 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.38377595472184e-31 9.84556591784592e-30 1.35389581736512 0.73542600896861 12.1 12 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 2.33196362056501e-05 8.07392757193189e-05 1.35004326829132 0.733333333333333 12.1 12 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00297631261573984 0.00728966067503922 1.35004326829132 0.733333333333333 12.1 12 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00297631261573984 0.00728966067503922 1.35004326829132 0.733333333333333 12.1 12 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.06650900571892e-07 9.64145021356729e-07 1.35004326829132 0.733333333333333 12.1 12 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 9.29702489234097e-05 0.000292691734995602 1.34532283728331 0.730769230769231 12.1 12 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.85467749119429e-18 7.52260383327681e-17 1.34148062599772 0.728682170542636 12.1 12 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 8.2243499034061e-29 5.31965905115767e-27 1.34127675356216 0.728571428571429 12.1 12 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0127019268891427 0.0271394023472222 1.33888588590875 0.727272727272727 12.1 12 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.0127019268891427 0.0271394023472222 1.33888588590875 0.727272727272727 12.1 12 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0127019268891427 0.0271394023472222 1.33888588590875 0.727272727272727 12.1 12 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0127019268891427 0.0271394023472222 1.33888588590875 0.727272727272727 12.1 12 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0127019268891427 0.0271394023472222 1.33888588590875 0.727272727272727 12.1 12 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.08927010786216e-10 1.98915446311668e-09 1.33403485009024 0.72463768115942 12.1 12 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 6.63024329532925e-43 7.86236350771127e-41 1.3327253680288 0.723926380368098 12.1 12 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 6.21412412681799e-12 4.65405191182211e-11 1.33082030828279 0.72289156626506 12.1 12 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00152315304117654 0.00391943359420292 1.3295880672566 0.722222222222222 12.1 12 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.000195337272954331 0.000595214003027866 1.32549702704966 0.72 12.1 12 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000195337272954331 0.000595214003027866 1.32549702704966 0.72 12.1 12 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 6.95135985220821e-12 5.17894506266611e-11 1.32116533741878 0.717647058823529 12.1 12 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 7.10649387395409e-10 4.26689484499437e-09 1.31497720937466 0.714285714285714 12.1 12 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 1.36997460788191e-05 4.87368466753989e-05 1.31497720937466 0.714285714285714 12.1 12 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00078355534843778 0.00210774907528726 1.31497720937466 0.714285714285714 12.1 12 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00078355534843778 0.00210774907528726 1.31497720937466 0.714285714285714 12.1 12 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000102185393695473 0.000320992969599686 1.31497720937466 0.714285714285714 12.1 12 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00631195730819971 0.0141670587532621 1.31497720937466 0.714285714285714 12.1 12 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00631195730819971 0.0141670587532621 1.31497720937466 0.714285714285714 12.1 12 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00631195730819971 0.0141670587532621 1.31497720937466 0.714285714285714 12.1 12 1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0569263292866944 0.0984279059234096 1.31497720937466 0.714285714285714 12.1 12 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.23384799802078e-14 2.54301256094686e-13 1.31254206639434 0.712962962962963 12.1 12 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.20688468598224e-14 1.51982027270153e-13 1.3102385527643 0.711711711711712 12.1 12 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 6.5167731246586e-15 8.35438572647675e-14 1.30805627669374 0.710526315789474 12.1 12 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000404872715615304 0.00114539537638286 1.30401906596321 0.708333333333333 12.1 12 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.02291897992453e-15 1.42707226316922e-14 1.30214816342954 0.707317073170732 12.1 12 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 3.82935109462317e-06 1.51365739101355e-05 1.30214816342954 0.707317073170732 12.1 12 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.29791348963819e-17 4.19221909712198e-16 1.29794872752665 0.705035971223022 12.1 12 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000209988851479378 0.000637130353209286 1.29549606553208 0.703703703703704 12.1 12 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000209988851479378 0.000637130353209286 1.29549606553208 0.703703703703704 12.1 12 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.22396447918376e-16 5.04143016909724e-15 1.29289362265234 0.702290076335878 12.1 12 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.22396447918376e-16 5.04143016909724e-15 1.29289362265234 0.702290076335878 12.1 12 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 5.96597563732935e-09 3.3688822745713e-08 1.291425378759 0.701492537313433 12.1 12 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.35256621728381e-21 1.22325685312689e-19 1.28971776015504 0.700564971751412 12.1 12 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.55542227379886e-32 1.9138767871662e-30 1.28934227460707 0.700361010830325 12.1 12 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 7.77256370841931e-06 2.93378200453068e-05 1.28867766518717 0.7 12.1 12 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0268617590263543 0.0511019827466607 1.28867766518717 0.7 12.1 12 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.0268617590263543 0.0511019827466607 1.28867766518717 0.7 12.1 12 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0268617590263543 0.0511019827466607 1.28867766518717 0.7 12.1 12 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0268617590263543 0.0511019827466607 1.28867766518717 0.7 12.1 12 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0268617590263543 0.0511019827466607 1.28867766518717 0.7 12.1 12 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0268617590263543 0.0511019827466607 1.28867766518717 0.7 12.1 12 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0268617590263543 0.0511019827466607 1.28867766518717 0.7 12.1 12 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0268617590263543 0.0511019827466607 1.28867766518717 0.7 12.1 12 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 6.90848702883686e-11 4.72633511636291e-10 1.28439634404037 0.697674418604651 12.1 12 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.19830903596449e-08 6.48362645694858e-08 1.28309897399588 0.696969696969697 12.1 12 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 5.7004891762295e-05 0.000188208726166463 1.28309897399588 0.696969696969697 12.1 12 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 6.83629708848559e-60 1.21600634461437e-57 1.28247215476091 0.696629213483146 12.1 12 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.59826598763123e-07 7.55592192823668e-07 1.2821027791403 0.696428571428571 12.1 12 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000826798905711457 0.00221569650249982 1.28067345608663 0.695652173913043 12.1 12 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.3982324196204e-09 1.98183800537698e-08 1.27845006466981 0.694444444444444 12.1 12 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.98119204011288e-05 0.000101488906054561 1.27845006466981 0.694444444444444 12.1 12 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 4.50309788250936e-08 2.28039440811773e-07 1.27680045168314 0.693548387096774 12.1 12 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000425663077023907 0.00120182253691472 1.27451637216314 0.692307692307692 12.1 12 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 8.20185277255619e-06 3.08762870247287e-05 1.27114463572884 0.69047619047619 12.1 12 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.31273298680301e-06 1.70000527429936e-05 1.26822246415245 0.688888888888889 12.1 12 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 8.94798277898317e-08 4.40587525761005e-07 1.26755180182345 0.688524590163934 12.1 12 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.47753277790772e-16 6.92557515539422e-15 1.26648159597929 0.687943262411348 12.1 12 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00649728729730568 0.0144689199124663 1.26566556402311 0.6875 12.1 12 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.00649728729730568 0.0144689199124663 1.26566556402311 0.6875 12.1 12 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00649728729730568 0.0144689199124663 1.26566556402311 0.6875 12.1 12 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 5.95187840589108e-05 0.000196053772490347 1.26237812099968 0.685714285714286 12.1 12 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 7.18435910341585e-28 4.0893372016643e-26 1.2603550791391 0.684615384615385 12.1 12 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 4.35996436069654e-11 3.02645330988838e-10 1.25960974792731 0.684210526315789 12.1 12 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.35996436069654e-11 3.02645330988838e-10 1.25960974792731 0.684210526315789 12.1 12 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.35996436069654e-11 3.02645330988838e-10 1.25960974792731 0.684210526315789 12.1 12 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 9.34504533652093e-08 4.58551707374803e-07 1.2565337778469 0.682539682539683 12.1 12 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.01325139203501e-10 1.94902578675719e-09 1.25520551803945 0.681818181818182 12.1 12 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.4808261413548e-06 1.76138552462649e-05 1.25342508468053 0.680851063829787 12.1 12 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00085013553126987 0.00227395274623501 1.25185830332468 0.68 12.1 12 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 2.08201493997529e-09 1.22425919817556e-08 1.2500400632327 0.679012345679012 12.1 12 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.88172752558024e-10 3.5615737314471e-09 1.24847261487755 0.67816091954023 12.1 12 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 9.67126619541503e-08 4.72445356634438e-07 1.24619378611507 0.676923076923077 12.1 12 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.97693791401654e-19 9.20909272096854e-18 1.24043839429781 0.67379679144385 12.1 12 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 4.60157590010361e-06 1.79891277633171e-05 1.23983565455325 0.673469387755102 12.1 12 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 4.60157590010361e-06 1.79891277633171e-05 1.23983565455325 0.673469387755102 12.1 12 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 6.72554240407273e-07 2.9538416175912e-06 1.23789233848029 0.672413793103448 12.1 12 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 6.72554240407273e-07 2.9538416175912e-06 1.23789233848029 0.672413793103448 12.1 12 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 6.72554240407273e-07 2.9538416175912e-06 1.23789233848029 0.672413793103448 12.1 12 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 5.25507002340496e-08 2.65176051181037e-07 1.23607857681218 0.671428571428571 12.1 12 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.14134829218664e-16 5.02262766267595e-15 1.2350798599443 0.670886075949367 12.1 12 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 8.90061957990166e-06 3.34184212722957e-05 1.22731206208302 0.666666666666667 12.1 12 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0129832466931194 0.0276829689796138 1.22731206208302 0.666666666666667 12.1 12 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0264047680118708 0.0507756552444489 1.22731206208302 0.666666666666667 12.1 12 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0264047680118708 0.0507756552444489 1.22731206208302 0.666666666666667 12.1 12 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 7.98180945620559e-09 4.47169876227581e-08 1.22731206208302 0.666666666666667 12.1 12 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00648697506576046 0.0144689199124663 1.22731206208302 0.666666666666667 12.1 12 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0550269524047353 0.0967010857694466 1.22731206208302 0.666666666666667 12.1 12 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0550269524047353 0.0967010857694466 1.22731206208302 0.666666666666667 12.1 12 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0550269524047353 0.0967010857694466 1.22731206208302 0.666666666666667 12.1 12 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0550269524047353 0.0967010857694466 1.22731206208302 0.666666666666667 12.1 12 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0550269524047353 0.0967010857694466 1.22731206208302 0.666666666666667 12.1 12 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 3.25180200553738e-05 0.000109134770138672 1.2133653341048 0.659090909090909 12.1 12 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 3.25180200553738e-05 0.000109134770138672 1.2133653341048 0.659090909090909 12.1 12 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 4.71066138071795e-06 1.83149484829553e-05 1.20499729731787 0.654545454545455 12.1 12 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 4.71066138071795e-06 1.83149484829553e-05 1.20499729731787 0.654545454545455 12.1 12 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 1.86240130479296e-10 1.21568672326623e-09 1.20437164970764 0.654205607476635 12.1 12 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 6.73471664938964e-19 1.95581669226152e-17 1.20101251789553 0.652380952380952 12.1 12 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 3.23451659422743e-05 0.000109069125914352 1.20063136508121 0.652173913043478 12.1 12 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.00322554446506909 0.0078193352194094 1.20063136508121 0.652173913043478 12.1 12 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00322554446506909 0.0078193352194094 1.20063136508121 0.652173913043478 12.1 12 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00322554446506909 0.0078193352194094 1.20063136508121 0.652173913043478 12.1 12 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00634213785829466 0.0142123813737847 1.19662926053094 0.65 12.1 12 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00022560436277322 0.000664668754091703 1.19414146581051 0.648648648648649 12.1 12 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.000433112653121519 0.00121802234267178 1.19121464849234 0.647058823529412 12.1 12 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000433112653121519 0.00121802234267178 1.19121464849234 0.647058823529412 12.1 12 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0125830866407412 0.0270888536910358 1.19121464849234 0.647058823529412 12.1 12 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0125830866407412 0.0270888536910358 1.19121464849234 0.647058823529412 12.1 12 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0125830866407412 0.0270888536910358 1.19121464849234 0.647058823529412 12.1 12 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0125830866407412 0.0270888536910358 1.19121464849234 0.647058823529412 12.1 12 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0125830866407412 0.0270888536910358 1.19121464849234 0.647058823529412 12.1 12 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.29270755171586e-06 5.49111297340796e-06 1.18954861401893 0.646153846153846 12.1 12 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 6.07098544566517e-05 0.000199055582700036 1.18640166001359 0.644444444444444 12.1 12 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 7.8461084023677e-12 5.81511055029648e-11 1.18547187814837 0.643939393939394 12.1 12 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0252713457629959 0.0494650963146398 1.1834794884372 0.642857142857143 12.1 12 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0252713457629959 0.0494650963146398 1.1834794884372 0.642857142857143 12.1 12 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0252713457629959 0.0494650963146398 1.1834794884372 0.642857142857143 12.1 12 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0252713457629959 0.0494650963146398 1.1834794884372 0.642857142857143 12.1 12 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0252713457629959 0.0494650963146398 1.1834794884372 0.642857142857143 12.1 12 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00312934596080845 0.0076251015449151 1.1782195795997 0.64 12.1 12 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.34090566061821e-22 1.32058576529436e-20 1.17767811839584 0.639705882352941 12.1 12 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 9.42866875862745e-11 6.35876570783264e-10 1.17701238740749 0.639344262295082 12.1 12 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00610788488014218 0.0137741999753444 1.17152515017015 0.636363636363636 12.1 12 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00610788488014218 0.0137741999753444 1.17152515017015 0.636363636363636 12.1 12 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00610788488014218 0.0137741999753444 1.17152515017015 0.636363636363636 12.1 12 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0516414652664745 0.0930200064230294 1.17152515017015 0.636363636363636 12.1 12 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0516414652664745 0.0930200064230294 1.17152515017015 0.636363636363636 12.1 12 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0516414652664745 0.0930200064230294 1.17152515017015 0.636363636363636 12.1 12 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0516414652664745 0.0930200064230294 1.17152515017015 0.636363636363636 12.1 12 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 3.046285422185e-05 0.000103318780412461 1.16830667448287 0.634615384615385 12.1 12 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.10198688212285e-75 7.47781833315202e-73 1.16649930225008 0.633633633633634 12.1 12 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00155670819239267 0.00399134370770229 1.16594645897887 0.633333333333333 12.1 12 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00010909667604 0.00034119685715367 1.16061031957851 0.630434782608696 12.1 12 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00300325585329105 0.00734301216363086 1.15912805863396 0.62962962962963 12.1 12 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.86883246614439e-12 1.46925336979197e-11 1.15650559696285 0.628205128205128 12.1 12 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 6.11288119938042e-07 2.71832185834948e-06 1.15650559696285 0.628205128205128 12.1 12 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 5.54794300141416e-10 3.38829308627139e-09 1.15631053783028 0.628099173553719 12.1 12 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 5.54794300141416e-10 3.38829308627139e-09 1.15631053783028 0.628099173553719 12.1 12 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000105022548022198 0.000329178603162087 1.15060505820283 0.625 12.1 12 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0237931790194756 0.0469593533213784 1.15060505820283 0.625 12.1 12 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0237931790194756 0.0469593533213784 1.15060505820283 0.625 12.1 12 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.108379417408521 0.179538895194791 1.15060505820283 0.625 12.1 12 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.108379417408521 0.179538895194791 1.15060505820283 0.625 12.1 12 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 7.04962141667653e-14 6.8709666273498e-13 1.14683258260217 0.622950819672131 12.1 12 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 4.23692706230929e-08 2.15326686059504e-07 1.14140021773721 0.62 12.1 12 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.21173922425495e-13 1.11245478459019e-12 1.14059979682715 0.619565217391304 12.1 12 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.78345819484758e-14 2.16911197544282e-13 1.14009191553905 0.619289340101523 12.1 12 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.01631869612847e-06 4.39581004434899e-06 1.13640005748428 0.617283950617284 12.1 12 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.047719328877861 0.0863926272178068 1.13290344192279 0.615384615384615 12.1 12 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.047719328877861 0.0863926272178068 1.13290344192279 0.615384615384615 12.1 12 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.047719328877861 0.0863926272178068 1.13290344192279 0.615384615384615 12.1 12 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.047719328877861 0.0863926272178068 1.13290344192279 0.615384615384615 12.1 12 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.047719328877861 0.0863926272178068 1.13290344192279 0.615384615384615 12.1 12 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.03034651861678e-13 9.52879336349542e-13 1.13142830723278 0.614583333333333 12.1 12 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00270092490585902 0.00663802442320791 1.12833528288278 0.612903225806452 12.1 12 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0013407533744771 0.00350715450713404 1.12503605690943 0.611111111111111 12.1 12 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0221626905442823 0.0444190262598785 1.12503605690943 0.611111111111111 12.1 12 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0221626905442823 0.0444190262598785 1.12503605690943 0.611111111111111 12.1 12 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.83541119813334e-11 1.99742085888304e-10 1.12310632096276 0.610062893081761 12.1 12 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.71504351046755e-06 7.13598513273488e-06 1.12254152019788 0.609756097560976 12.1 12 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.000337100567462971 0.000963241179718489 1.1205892740758 0.608695652173913 12.1 12 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.17113491179102e-06 1.26756319648276e-05 1.11856289202503 0.607594936708861 12.1 12 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00515337976200741 0.0120811522262546 1.11773062796846 0.607142857142857 12.1 12 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00253861525945162 0.00628252089426026 1.11573823825729 0.606060606060606 12.1 12 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00253861525945162 0.00628252089426026 1.11573823825729 0.606060606060606 12.1 12 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 8.63030969353538e-11 5.84806223519088e-10 1.11396158501166 0.605095541401274 12.1 12 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.54333365349832e-06 6.49752600274589e-06 1.11314349816832 0.604651162790698 12.1 12 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.11537041717406e-05 7.37787280303601e-05 1.10999546791332 0.602941176470588 12.1 12 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 7.60284779652642e-15 9.65968965576526e-14 1.10616108599757 0.600858369098712 12.1 12 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 2.68132288962754e-06 1.08704343929914e-05 1.10458085587472 0.6 12.1 12 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 2.68132288962754e-06 1.08704343929914e-05 1.10458085587472 0.6 12.1 12 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00480941986615164 0.0114444890794879 1.10458085587472 0.6 12.1 12 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0437034943678105 0.0798332124331121 1.10458085587472 0.6 12.1 12 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0437034943678105 0.0798332124331121 1.10458085587472 0.6 12.1 12 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0437034943678105 0.0798332124331121 1.10458085587472 0.6 12.1 12 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0972747424723064 0.162467087486024 1.10458085587472 0.6 12.1 12 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0972747424723064 0.162467087486024 1.10458085587472 0.6 12.1 12 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0972747424723064 0.162467087486024 1.10458085587472 0.6 12.1 12 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.67248881615244e-07 7.86146615614468e-07 1.09782500966142 0.596330275229358 12.1 12 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.6937969004992e-37 5.78733784957883e-35 1.09656419854851 0.595645412130638 12.1 12 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00911501687079702 0.0201721135414373 1.09094405518491 0.592592592592593 12.1 12 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00911501687079702 0.0201721135414373 1.09094405518491 0.592592592592593 12.1 12 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.29819285143988e-09 7.6972017816623e-09 1.09004689724479 0.592105263157895 12.1 12 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.64965183711566e-05 5.83943921446662e-05 1.09004689724479 0.592105263157895 12.1 12 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.12194616688328e-27 6.1404976749035e-26 1.08886527459195 0.591463414634146 12.1 12 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0188513779359335 0.0379964742249764 1.08784478230086 0.590909090909091 12.1 12 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 5.93326997557178e-10 3.577560667474e-09 1.08628552078777 0.590062111801242 12.1 12 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00413981796751149 0.00988416269759875 1.08292240772031 0.588235294117647 12.1 12 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0398075967033822 0.0747311479009405 1.08292240772031 0.588235294117647 12.1 12 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0398075967033822 0.0747311479009405 1.08292240772031 0.588235294117647 12.1 12 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0398075967033822 0.0747311479009405 1.08292240772031 0.588235294117647 12.1 12 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0398075967033822 0.0747311479009405 1.08292240772031 0.588235294117647 12.1 12 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 9.39407111783195e-10 5.61670722717432e-09 1.07958005461006 0.58641975308642 12.1 12 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.38396239375146e-08 7.40367851995612e-08 1.07828131168722 0.585714285714286 12.1 12 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0869728414229199 0.146637859413288 1.07389805432264 0.583333333333333 12.1 12 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0869728414229199 0.146637859413288 1.07389805432264 0.583333333333333 12.1 12 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 7.32594605201524e-40 8.01909325539822e-38 1.07016583134256 0.581306017925736 12.1 12 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00082068171906171 0.00220345299287701 1.06776149401223 0.58 12.1 12 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0361328756034014 0.0683737792335642 1.06582363286157 0.578947368421053 12.1 12 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.61810354903925e-08 1.84536249114081e-07 1.06513153959348 0.578571428571429 12.1 12 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0157876518520278 0.0327490212615678 1.06209697680261 0.576923076923077 12.1 12 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0157876518520278 0.0327490212615678 1.06209697680261 0.576923076923077 12.1 12 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.00737822220038e-08 3.02067109900747e-07 1.05954998165441 0.575539568345324 12.1 12 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 1.30339630893328e-08 6.99899225513986e-08 1.0570720018586 0.574193548387097 12.1 12 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.26460830547566e-07 1.9265198789498e-06 1.05410269848259 0.57258064516129 12.1 12 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0327225845192159 0.0620856503611256 1.05198176749973 0.571428571428571 12.1 12 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0143971996825164 0.0305779330570461 1.05198176749973 0.571428571428571 12.1 12 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0776499730310143 0.132014231329908 1.05198176749973 0.571428571428571 12.1 12 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0776499730310143 0.132014231329908 1.05198176749973 0.571428571428571 12.1 12 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0776499730310143 0.132014231329908 1.05198176749973 0.571428571428571 12.1 12 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 9.62227659301252e-09 5.24616842599878e-08 1.05036829853117 0.570552147239264 12.1 12 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 6.83686501101625e-06 2.61528465340756e-05 1.04935181308098 0.57 12.1 12 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.000132061326721313 0.000412112429658833 1.04832905302925 0.569444444444444 12.1 12 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 7.01397852750046e-07 3.07104352142558e-06 1.04770541885136 0.569105691056911 12.1 12 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.0131079767992591 0.0278813916073927 1.04321525277057 0.566666666666667 12.1 12 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.28748101860722e-07 6.18947800499349e-07 1.04278612267893 0.566433566433566 12.1 12 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0119192738715648 0.0258553760963975 1.03554455238255 0.5625 12.1 12 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0693024712442412 0.118816164554886 1.03554455238255 0.5625 12.1 12 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0693024712442412 0.118816164554886 1.03554455238255 0.5625 12.1 12 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.86418513804449e-06 7.68908826503567e-06 1.03459363911131 0.56198347107438 12.1 12 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 6.72288790700324e-08 3.35672613742653e-07 1.03047899552254 0.559748427672956 12.1 12 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 6.72288790700324e-08 3.35672613742653e-07 1.03047899552254 0.559748427672956 12.1 12 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.4524466090526e-06 6.15128429964837e-06 1.02920263473891 0.559055118110236 12.1 12 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.010827800733124 0.023741079265386 1.0287762873343 0.558823529411765 12.1 12 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00450643402213274 0.0107414666892712 1.0275170752323 0.558139534883721 12.1 12 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 4.66370424379425e-09 2.68682232344907e-08 1.02595617689752 0.557291666666667 12.1 12 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0241284455785662 0.0475550942635729 1.02276005173585 0.555555555555556 12.1 12 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0618637294022572 0.106447505368092 1.02276005173585 0.555555555555556 12.1 12 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.175069998663254 0.267588193445554 1.02276005173585 0.555555555555556 12.1 12 1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.175069998663254 0.267588193445554 1.02276005173585 0.555555555555556 12.1 12 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.175069998663254 0.267588193445554 1.02276005173585 0.555555555555556 12.1 12 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.175069998663254 0.267588193445554 1.02276005173585 0.555555555555556 12.1 12 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.175069998663254 0.267588193445554 1.02276005173585 0.555555555555556 12.1 12 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.175069998663254 0.267588193445554 1.02276005173585 0.555555555555556 12.1 12 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.4194640862308e-61 2.88556770672347e-59 1.01853431620899 0.553260167850226 12.1 12 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.055248055327168 0.0967010857694466 1.01253245121849 0.55 12.1 12 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.055248055327168 0.0967010857694466 1.01253245121849 0.55 12.1 12 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.055248055327168 0.0967010857694466 1.01253245121849 0.55 12.1 12 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.54881924924437e-10 1.0203563850346e-09 1.00814919385391 0.547619047619048 12.1 12 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.54881924924437e-10 1.0203563850346e-09 1.00814919385391 0.547619047619048 12.1 12 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.54881924924437e-10 1.0203563850346e-09 1.00814919385391 0.547619047619048 12.1 12 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.00109495131048486 0.00289075271766224 1.00677942592748 0.546875 12.1 12 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00664070513082966 0.0147651928143291 1.00416441443156 0.545454545454545 12.1 12 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.152034675119305 0.234902652220163 1.00416441443156 0.545454545454545 12.1 12 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.152034675119305 0.234902652220163 1.00416441443156 0.545454545454545 12.1 12 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.152034675119305 0.234902652220163 1.00416441443156 0.545454545454545 12.1 12 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.152034675119305 0.234902652220163 1.00416441443156 0.545454545454545 12.1 12 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0177139241981633 0.0358052757585033 1.00416441443156 0.545454545454545 12.1 12 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0177139241981633 0.0358052757585033 1.00416441443156 0.545454545454545 12.1 12 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0159759095087668 0.0330912943682317 0.999382679124744 0.542857142857143 12.1 12 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00210575534929465 0.00532236209954935 0.998491169152287 0.542372881355932 12.1 12 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000297729348959037 0.000861115576359167 0.998115231212094 0.542168674698795 12.1 12 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0441413519653184 0.080426560623109 0.997191050442453 0.541666666666667 12.1 12 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0441413519653184 0.080426560623109 0.997191050442453 0.541666666666667 12.1 12 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0129952377219831 0.0276829689796138 0.991290511682439 0.538461538461538 12.1 12 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0394932128264722 0.0746332561116466 0.991290511682439 0.538461538461538 12.1 12 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.132768606058822 0.207615083979894 0.991290511682439 0.538461538461538 12.1 12 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.132768606058822 0.207615083979894 0.991290511682439 0.538461538461538 12.1 12 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.132768606058822 0.207615083979894 0.991290511682439 0.538461538461538 12.1 12 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.361791579491e-13 1.24219834462544e-12 0.989397290689921 0.537433155080214 12.1 12 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 6.38514135929115e-06 2.46234584126594e-05 0.986232907030998 0.535714285714286 12.1 12 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0353568062278542 0.0669943212546425 0.986232907030998 0.535714285714286 12.1 12 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 5.81926878049171e-06 2.2563540802833e-05 0.985306866742706 0.535211267605634 12.1 12 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.3451233848387e-15 3.14821752511837e-14 0.982400013819816 0.533632286995516 12.1 12 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.116445948646104 0.192566506449889 0.981849649666415 0.533333333333333 12.1 12 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 1.08096471256712e-05 3.92401220914032e-05 0.980953801445917 0.532846715328467 12.1 12 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 1.65801548021733e-05 5.85448145992374e-05 0.97463016694828 0.529411764705882 12.1 12 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.102484205102707 0.170567279369769 0.97463016694828 0.529411764705882 12.1 12 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.27543797900798e-18 6.10933630967615e-17 0.973681898640294 0.528896672504378 12.1 12 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0904535669565408 0.151787058701837 0.968930575328699 0.526315789473684 12.1 12 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0904535669565408 0.151787058701837 0.968930575328699 0.526315789473684 12.1 12 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0904535669565408 0.151787058701837 0.968930575328699 0.526315789473684 12.1 12 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 2.29721017669142e-05 7.99249408663053e-05 0.967516078138439 0.525547445255474 12.1 12 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0184222236366299 0.0371841478509565 0.966508248890378 0.525 12.1 12 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0165540027957246 0.0338459096613971 0.964316620208087 0.523809523809524 12.1 12 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 9.71052900484758e-06 3.5891124088047e-05 0.962054293826367 0.52258064516129 12.1 12 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0709449557101319 0.121485766516869 0.960505092064972 0.521739130434783 12.1 12 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.0939022471945e-05 3.96087251337857e-05 0.955002198308349 0.51875 12.1 12 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0560398852472942 0.0979665315809577 0.954576048286793 0.518518518518518 12.1 12 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00102647870910391 0.00271501710604994 0.951511598693577 0.51685393258427 12.1 12 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.734056648317e-07 1.69221739189653e-06 0.949378164615789 0.515695067264574 12.1 12 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0397325263155611 0.0747311479009405 0.948377502518697 0.515151515151515 12.1 12 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.0015373343424471 0.00394878478213397 0.941404138529589 0.511363636363636 12.1 12 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.020466305490295 0.0411349614586015 0.940939247596981 0.511111111111111 12.1 12 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.016491525152561 0.0338459096613971 0.939269435267617 0.510204081632653 12.1 12 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00309720659791406 0.00755973411463415 0.931848047137107 0.506172839506173 12.1 12 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00252485528610241 0.00627027761278137 0.931313270639468 0.505882352941176 12.1 12 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00252485528610241 0.00627027761278137 0.931313270639468 0.505882352941176 12.1 12 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00252485528610241 0.00627027761278137 0.931313270639468 0.505882352941176 12.1 12 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00252485528610241 0.00627027761278137 0.931313270639468 0.505882352941176 12.1 12 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00252485528610241 0.00627027761278137 0.931313270639468 0.505882352941176 12.1 12 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 6.95727180280666e-05 0.00022654914817835 0.926347002272852 0.503184713375796 12.1 12 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00246530909676385 0.00617629374066014 0.920484046562265 0.5 12.1 12 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00765407169659435 0.0169918003498499 0.920484046562265 0.5 12.1 12 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0606272719000063 0.104446256554127 0.920484046562265 0.5 12.1 12 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0606272719000063 0.104446256554127 0.920484046562265 0.5 12.1 12 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.163589426047968 0.252207750017615 0.920484046562265 0.5 12.1 12 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0767229642667339 0.13090740785559 0.920484046562264 0.5 12.1 12 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0767229642667339 0.13090740785559 0.920484046562264 0.5 12.1 12 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0977485594549454 0.162876112534411 0.920484046562264 0.5 12.1 12 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0977485594549454 0.162876112534411 0.920484046562264 0.5 12.1 12 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.125659078585913 0.200462857430218 0.920484046562264 0.5 12.1 12 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.143104680803158 0.222798644182597 0.920484046562264 0.5 12.1 12 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.143104680803158 0.222798644182597 0.920484046562264 0.5 12.1 12 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.187887239086629 0.286563281050668 0.920484046562264 0.5 12.1 12 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.217096508815689 0.328297908655394 0.920484046562264 0.5 12.1 12 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.252865254854202 0.373264790101171 0.920484046562264 0.5 12.1 12 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.252865254854202 0.373264790101171 0.920484046562264 0.5 12.1 12 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.252865254854202 0.373264790101171 0.920484046562264 0.5 12.1 12 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.252865254854202 0.373264790101171 0.920484046562264 0.5 12.1 12 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0261900033704213 0.0504991528402569 0.903116423042222 0.490566037735849 12.1 12 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0325663858377762 0.061871785109687 0.901698657856912 0.489795918367347 12.1 12 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0802929148030139 0.136182142746947 0.892590590605832 0.484848484848485 12.1 12 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0802929148030139 0.136182142746947 0.892590590605832 0.484848484848485 12.1 12 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0903172231555837 0.151787058701837 0.890791012802191 0.483870967741935 12.1 12 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.147111675790008 0.228537024726181 0.880463001059557 0.478260869565217 12.1 12 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.147111675790008 0.228537024726181 0.880463001059557 0.478260869565217 12.1 12 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0656777368945414 0.112873695170208 0.876651472916442 0.476190476190476 12.1 12 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00328858175313106 0.00795859155562161 0.875214339354284 0.475409836065574 12.1 12 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.082344857435568 0.13949610967954 0.872037517795829 0.473684210526316 12.1 12 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.116514238969328 0.192566506449889 0.862953793652123 0.46875 12.1 12 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.147831972557513 0.229405558287176 0.854735186093531 0.464285714285714 12.1 12 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0605271574420498 0.104446256554127 0.852300043113208 0.462962962962963 12.1 12 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.104205561034975 0.1730274368177 0.84967758144209 0.461538461538462 12.1 12 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.289377568321577 0.417207983507197 0.84967758144209 0.461538461538462 12.1 12 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.289377568321577 0.417207983507197 0.84967758144209 0.461538461538462 12.1 12 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.289377568321577 0.417207983507197 0.84967758144209 0.461538461538462 12.1 12 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.116676783858967 0.192611442495719 0.845850204949108 0.459459459459459 12.1 12 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0166969983009844 0.0338459096613971 0.836803678692968 0.454545454545455 12.1 12 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0748885156648482 0.128084564652739 0.836803678692968 0.454545454545455 12.1 12 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.336890737966616 0.480356232591678 0.836803678692968 0.454545454545455 12.1 12 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.336890737966616 0.480356232591678 0.836803678692968 0.454545454545455 12.1 12 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.336890737966616 0.480356232591678 0.836803678692968 0.454545454545455 12.1 12 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0832034090623394 0.14078293828265 0.833645928962051 0.452830188679245 12.1 12 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.164761379856786 0.253465344363467 0.831404945282045 0.451612903225806 12.1 12 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.164761379856786 0.253465344363467 0.831404945282045 0.451612903225806 12.1 12 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.243534723457185 0.360989491124556 0.828435641906038 0.45 12.1 12 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.185276647120355 0.282884837824319 0.825261558986858 0.448275862068966 12.1 12 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.18454578727582e-05 4.27819455658246e-05 0.81820804138868 0.444444444444444 12.1 12 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.161501763953171 0.2492592300492 0.81820804138868 0.444444444444444 12.1 12 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.277745575756234 0.408297473451571 0.81820804138868 0.444444444444444 12.1 12 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0435505584678678 0.0798332124331121 0.818208041388679 0.444444444444444 12.1 12 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.208630970868093 0.316168127311285 0.818208041388679 0.444444444444444 12.1 12 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.12465423661291 0.199083028844188 0.810025960974793 0.44 12.1 12 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.235285540247771 0.353904971622901 0.810025960974793 0.44 12.1 12 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.235285540247771 0.353904971622901 0.810025960974793 0.44 12.1 12 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.235285540247771 0.353904971622901 0.810025960974793 0.44 12.1 12 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.317916434357515 0.454668428231903 0.805423540741982 0.4375 12.1 12 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.138285628428255 0.215768036462068 0.805423540741981 0.4375 12.1 12 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.138285628428255 0.215768036462068 0.805423540741981 0.4375 12.1 12 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00351196655914897 0.00848476810470116 0.80136258171303 0.435294117647059 12.1 12 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.084812878718975 0.143335779592757 0.799367724646177 0.434210526315789 12.1 12 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.226674159884751 0.342417547256901 0.797752840353963 0.433333333333333 12.1 12 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0200709037284861 0.0403973069386644 0.792044412158228 0.430232558139535 12.1 12 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.365495315247787 0.505442015158018 0.788986325624798 0.428571428571429 12.1 12 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.243246703010936 0.360938538461483 0.781016766780103 0.424242424242424 12.1 12 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.285408605057672 0.413160167850526 0.778871116321916 0.423076923076923 12.1 12 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.285408605057672 0.413160167850526 0.778871116321916 0.423076923076923 12.1 12 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.0914515876346427 0.153281047354648 0.771453296166469 0.419047619047619 12.1 12 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.213902034504471 0.323811271382832 0.767070038801887 0.416666666666667 12.1 12 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.422458044502992 0.576373727064005 0.767070038801887 0.416666666666667 12.1 12 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.422458044502992 0.576373727064005 0.767070038801887 0.416666666666667 12.1 12 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.422458044502992 0.576373727064005 0.767070038801887 0.416666666666667 12.1 12 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.422458044502992 0.576373727064005 0.767070038801887 0.416666666666667 12.1 12 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.287046136758933 0.415108386796709 0.758045685404218 0.411764705882353 12.1 12 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.387924313808258 0.535938153931214 0.758045685404218 0.411764705882353 12.1 12 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.272738442311453 0.401351399595861 0.755268961281858 0.41025641025641 12.1 12 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.272738442311453 0.401351399595861 0.755268961281858 0.41025641025641 12.1 12 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.103741548051593 0.172458204296047 0.753782211358075 0.409448818897638 12.1 12 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.338193228563007 0.481730694940099 0.750024037939623 0.407407407407407 12.1 12 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.40631631667211 0.556485195981147 0.736387237249812 0.4 12.1 12 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.442226613264919 0.593668368562245 0.736387237249812 0.4 12.1 12 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.309937656588437 0.443703506363527 0.728716536861793 0.395833333333333 12.1 12 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.458038056205001 0.613159128861445 0.715932036215095 0.388888888888889 12.1 12 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.458038056205001 0.613159128861445 0.715932036215095 0.388888888888889 12.1 12 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.271724078439295 0.4006874234395 0.712632810241753 0.387096774193548 12.1 12 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.405723090116004 0.556208051286198 0.712632810241753 0.387096774193548 12.1 12 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.43537869705196 0.591983367652826 0.708064651201742 0.384615384615385 12.1 12 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.505633342116376 0.663760374383398 0.708064651201742 0.384615384615385 12.1 12 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.505633342116376 0.663760374383398 0.708064651201742 0.384615384615385 12.1 12 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.505633342116376 0.663760374383398 0.708064651201742 0.384615384615385 12.1 12 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.505633342116376 0.663760374383398 0.708064651201742 0.384615384615385 12.1 12 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.505633342116376 0.663760374383398 0.708064651201742 0.384615384615385 12.1 12 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.471232176557489 0.627519971979965 0.701321178333154 0.380952380952381 12.1 12 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.516812720609362 0.677186465402506 0.690363034921698 0.375 12.1 12 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.516812720609362 0.677186465402506 0.690363034921698 0.375 12.1 12 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.49254661969252 0.650179814306546 0.681840034490566 0.37037037037037 12.1 12 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.52619144268267 0.6882081093175 0.67825140273009 0.368421052631579 12.1 12 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.52619144268267 0.6882081093175 0.67825140273009 0.368421052631579 12.1 12 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.430736917478373 0.587105970854142 0.675798413931789 0.367088607594937 12.1 12 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.501459460444428 0.661331614654699 0.675021634145661 0.366666666666667 12.1 12 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.449070721687102 0.602288064995991 0.669442942954374 0.363636363636364 12.1 12 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.460275009640678 0.615574566464929 0.665882076236532 0.361702127659574 12.1 12 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.400172390734629 0.549127591143083 0.665410154141396 0.36144578313253 12.1 12 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.491656038905748 0.649606818349934 0.663955705717043 0.360655737704918 12.1 12 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.541569967160734 0.706374026828345 0.66274851352483 0.36 12.1 12 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.583487801487814 0.727697757683751 0.657488604687332 0.357142857142857 12.1 12 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.583487801487814 0.727697757683751 0.657488604687332 0.357142857142857 12.1 12 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.583487801487814 0.727697757683751 0.657488604687332 0.357142857142857 12.1 12 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.583487801487814 0.727697757683751 0.657488604687332 0.357142857142857 12.1 12 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.533524265340144 0.696518375760574 0.649753444632187 0.352941176470588 12.1 12 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.533524265340144 0.696518375760574 0.649753444632187 0.352941176470588 12.1 12 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.587115487955419 0.731580857583679 0.649753444632187 0.352941176470588 12.1 12 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.590739587457588 0.734809819014115 0.644338832593585 0.35 12.1 12 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.590739587457588 0.734809819014115 0.644338832593585 0.35 12.1 12 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.573950826942746 0.726009405439176 0.640336728043314 0.347826086956522 12.1 12 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.576009642455524 0.726009405439176 0.639494179716942 0.347368421052632 12.1 12 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.717411481681427 0.877795819804532 0.637603583472398 0.346341463414634 12.1 12 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.597898731624978 0.743065410569732 0.633775900911723 0.344262295081967 12.1 12 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.654586790391159 0.809980002370974 0.626924269550515 0.340540540540541 12.1 12 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.62527531501561 0.776410796917289 0.625234446721538 0.339622641509434 12.1 12 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.65195858440858 0.808133332415862 0.61365603104151 0.333333333333333 12.1 12 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.654118395599262 0.809980002370974 0.61365603104151 0.333333333333333 12.1 12 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.658735604829878 0.813013066529597 0.61365603104151 0.333333333333333 12.1 12 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.651654203830627 0.808133332415862 0.61365603104151 0.333333333333333 12.1 12 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.698911535371368 0.857371650718498 0.604067655556486 0.328125 12.1 12 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.695188144966101 0.853539888081762 0.600315682540607 0.326086956521739 12.1 12 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.701275385100881 0.859530467699012 0.589109789799849 0.32 12.1 12 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.730569337941875 0.881764349356479 0.587543008443999 0.319148936170213 12.1 12 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.716530066049216 0.877471845084366 0.575302529101415 0.3125 12.1 12 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.742822514791255 0.890510900208893 0.57133492545244 0.310344827586207 12.1 12 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.810983076668326 0.959292533748152 0.564167641441388 0.306451612903226 12.1 12 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.760483167648496 0.910149325116745 0.552290427937359 0.3 12.1 12 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.760483167648496 0.910149325116745 0.552290427937359 0.3 12.1 12 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.782156323716168 0.931387823136491 0.552290427937359 0.3 12.1 12 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.782156323716168 0.931387823136491 0.552290427937359 0.3 12.1 12 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.954772523338166 1 0.538819929694984 0.292682926829268 12.1 12 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.795341795973299 0.944717341961607 0.536949027161321 0.291666666666667 12.1 12 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.92990330086216 1 0.531048488401306 0.288461538461538 12.1 12 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.804479117544839 0.952390835496095 0.525990883749865 0.285714285714286 12.1 12 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.823727130284391 0.964743791271349 0.525990883749865 0.285714285714286 12.1 12 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.873485049702838 1 0.502082207215781 0.272727272727273 12.1 12 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.997820383745611 1 0.498144307551343 0.270588235294118 12.1 12 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.889512873046037 1 0.497558944087711 0.27027027027027 12.1 12 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.903193936251872 1 0.493918268887069 0.268292682926829 12.1 12 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.903193936251872 1 0.493918268887069 0.268292682926829 12.1 12 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.969329766167459 1 0.4934553651674 0.268041237113402 12.1 12 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.960113495520354 1 0.489371265260951 0.265822784810127 12.1 12 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.895911760309346 1 0.48731508347414 0.264705882352941 12.1 12 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.90875716681811 1 0.48446528766435 0.263157894736842 12.1 12 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.992963473736832 1 0.446295295302916 0.242424242424242 12.1 12 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.920507180775138 1 0.441832342349887 0.24 12.1 12 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.984944047008186 1 0.440795177227 0.23943661971831 12.1 12 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.944057313675701 1 0.429559221729057 0.233333333333333 12.1 12 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.967783546657071 1 0.428132114680123 0.232558139534884 12.1 12 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999869772400576 1 0.425600150561047 0.231182795698925 12.1 12 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.937725910272255 1 0.424838790721045 0.230769230769231 12.1 12 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.931010578546682 1 0.418401839346484 0.227272727272727 12.1 12 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.931010578546682 1 0.418401839346484 0.227272727272727 12.1 12 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.955997507111676 1 0.415702472641023 0.225806451612903 12.1 12 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.955997507111676 1 0.415702472641023 0.225806451612903 12.1 12 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.955997507111676 1 0.415702472641023 0.225806451612903 12.1 12 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.981379105841457 1 0.413278551517751 0.224489795918367 12.1 12 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.993210063406768 1 0.38757223013148 0.210526315789474 12.1 12 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.971184312674875 1 0.380889950301627 0.206896551724138 12.1 12 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.996077062641192 1 0.379882304930458 0.206349206349206 12.1 12 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.985046591274831 1 0.377634480640929 0.205128205128205 12.1 12 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999999979808 1 0.37009152387555 0.201030927835052 12.1 12 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.984060842166477 1 0.368193618624906 0.2 12.1 12 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999996651268 1 0.361618732578033 0.196428571428571 12.1 12 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999999908470076 1 0.356316405120877 0.193548387096774 12.1 12 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.309146615134262 0.167926112510495 12.1 12 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999990700369 1 0.303341333526201 0.164772727272727 12.1 12 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.246350160743608 0.133815551537071 12.1 12 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999958132356 1 0.238644012071698 0.12962962962963 12.1 12 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.99990954687077 1 0.230121011640566 0.125 12.1 12 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999992452065 1 0.184096809312453 0.1 12.1 12 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 1.61460924027144e-08 1.25551308683402e-07 2.97329585382994 1 12.3 12 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 6.38475257227535e-05 0.000265657979834732 2.97329585382994 1 12.3 12 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 1.60592989338918e-05 7.39559300418385e-05 2.97329585382994 1 12.3 12 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 1.60592989338918e-05 7.39559300418385e-05 2.97329585382994 1 12.3 12 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00100893864062372 0.00310761836711593 2.97329585382994 1 12.3 12 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00100893864062372 0.00310761836711593 2.97329585382994 1 12.3 12 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 4.95512516733325e-10 4.66963120073856e-09 2.69012482013185 0.904761904761905 12.3 12 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 1.78717425165925e-09 1.60958794943742e-08 2.67596626844694 0.9 12.3 12 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 3.12481844769101e-05 0.000138093684815662 2.67596626844694 0.9 12.3 12 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.000112221903659869 0.000419138501070849 2.64292964784883 0.888888888888889 12.3 12 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.000112221903659869 0.000419138501070849 2.64292964784883 0.888888888888889 12.3 12 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000112221903659869 0.000419138501070849 2.64292964784883 0.888888888888889 12.3 12 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.000398365113244785 0.0013091768040354 2.60163387210119 0.875 12.3 12 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.000398365113244785 0.0013091768040354 2.60163387210119 0.875 12.3 12 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.000398365113244785 0.0013091768040354 2.60163387210119 0.875 12.3 12 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0013936451131565 0.0041488640084136 2.5485393032828 0.857142857142857 12.3 12 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0013936451131565 0.0041488640084136 2.5485393032828 0.857142857142857 12.3 12 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0013936451131565 0.0041488640084136 2.5485393032828 0.857142857142857 12.3 12 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 3.99204345828551e-05 0.00017008017488444 2.47774654485828 0.833333333333333 12.3 12 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 3.99204345828551e-05 0.00017008017488444 2.47774654485828 0.833333333333333 12.3 12 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00478453879553305 0.0124695946997134 2.47774654485828 0.833333333333333 12.3 12 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.000133080145412016 0.000480642251069286 2.43269660767904 0.818181818181818 12.3 12 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000133080145412016 0.000480642251069286 2.43269660767904 0.818181818181818 12.3 12 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000133080145412016 0.000480642251069286 2.43269660767904 0.818181818181818 12.3 12 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 4.24439768309077e-05 0.000179221896232586 2.33616102800924 0.785714285714286 12.3 12 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.57856765723762e-08 3.37580402914463e-07 2.28715065679226 0.769230769230769 12.3 12 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.33070677698971e-05 6.24949090315628e-05 2.27369682939936 0.764705882352941 12.3 12 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 5.4531874886976e-11 5.87870136092173e-10 2.26909420423864 0.763157894736842 12.3 12 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 1.40859277222417e-07 8.94833711997765e-07 2.25970484891075 0.76 12.3 12 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.40859277222417e-07 8.94833711997765e-07 2.25970484891075 0.76 12.3 12 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.40859277222417e-07 8.94833711997765e-07 2.25970484891075 0.76 12.3 12 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.40859277222417e-07 8.94833711997765e-07 2.25970484891075 0.76 12.3 12 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 4.73382228373998e-09 3.91641227311744e-08 2.22997189037245 0.75 12.3 12 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 4.07802041410947e-05 0.000173224568635157 2.22997189037245 0.75 12.3 12 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000412559277899498 0.0013527001208548 2.22997189037245 0.75 12.3 12 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00437948511289165 0.0114736773359865 2.22997189037245 0.75 12.3 12 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00437948511289165 0.0114736773359865 2.22997189037245 0.75 12.3 12 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00437948511289165 0.0114736773359865 2.22997189037245 0.75 12.3 12 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00437948511289165 0.0114736773359865 2.22997189037245 0.75 12.3 12 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00437948511289165 0.0114736773359865 2.22997189037245 0.75 12.3 12 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00437948511289165 0.0114736773359865 2.22997189037245 0.75 12.3 12 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.63820286404886e-11 1.9589602315475e-10 2.18041695947529 0.733333333333333 12.3 12 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 4.21522951446917e-08 3.12409979119252e-07 2.18041695947529 0.733333333333333 12.3 12 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000122716328341391 0.000450065296984018 2.18041695947529 0.733333333333333 12.3 12 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000122716328341391 0.000450065296984018 2.18041695947529 0.733333333333333 12.3 12 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000122716328341391 0.000450065296984018 2.18041695947529 0.733333333333333 12.3 12 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.80397623293238e-11 5.25850629189445e-10 2.16239698460359 0.727272727272727 12.3 12 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 3.80838011238066e-06 1.97785580288966e-05 2.16239698460359 0.727272727272727 12.3 12 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00124421447367087 0.00375905986419033 2.16239698460359 0.727272727272727 12.3 12 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00124421447367087 0.00375905986419033 2.16239698460359 0.727272727272727 12.3 12 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00124421447367087 0.00375905986419033 2.16239698460359 0.727272727272727 12.3 12 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 3.67949099966592e-05 0.000158184764124611 2.14738033887718 0.722222222222222 12.3 12 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 1.1676047463753e-06 6.46498659179789e-06 2.14077301475755 0.72 12.3 12 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.6484413430253e-14 4.59947457083334e-13 2.12378275273567 0.714285714285714 12.3 12 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00036163199743603 0.00120798669566073 2.12378275273567 0.714285714285714 12.3 12 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00036163199743603 0.00120798669566073 2.12378275273567 0.714285714285714 12.3 12 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00036163199743603 0.00120798669566073 2.12378275273567 0.714285714285714 12.3 12 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00036163199743603 0.00120798669566073 2.12378275273567 0.714285714285714 12.3 12 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0132617730014744 0.031192566910906 2.12378275273567 0.714285714285714 12.3 12 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0132617730014744 0.031192566910906 2.12378275273567 0.714285714285714 12.3 12 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.64065362194541e-15 5.42941884657749e-14 2.11147096866184 0.710144927536232 12.3 12 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.64065362194541e-15 5.42941884657749e-14 2.11147096866184 0.710144927536232 12.3 12 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 3.36941166438664e-06 1.78905701433664e-05 2.10608456312954 0.708333333333333 12.3 12 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.23139602702044e-11 1.73492727371295e-10 2.09879707329172 0.705882352941177 12.3 12 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.23139602702044e-11 1.73492727371295e-10 2.09879707329172 0.705882352941177 12.3 12 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000106715731431969 0.000402802349675574 2.09879707329172 0.705882352941177 12.3 12 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 3.14067339090053e-07 1.85762974401749e-06 2.08130709768096 0.7 12.3 12 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.14067339090053e-07 1.85762974401749e-06 2.08130709768096 0.7 12.3 12 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 3.18339426831804e-05 0.000138531194000507 2.08130709768096 0.7 12.3 12 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 3.18339426831804e-05 0.000138531194000507 2.08130709768096 0.7 12.3 12 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 3.18339426831804e-05 0.000138531194000507 2.08130709768096 0.7 12.3 12 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 3.18339426831804e-05 0.000138531194000507 2.08130709768096 0.7 12.3 12 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00364861533505933 0.0099273032921404 2.08130709768096 0.7 12.3 12 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00364861533505933 0.0099273032921404 2.08130709768096 0.7 12.3 12 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00364861533505933 0.0099273032921404 2.08130709768096 0.7 12.3 12 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.08423514208047e-11 1.57435368079643e-10 2.07569710550392 0.69811320754717 12.3 12 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.9638095573671e-08 2.24335159581563e-07 2.0647887873819 0.694444444444444 12.3 12 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 2.89715399085657e-06 1.55571702980713e-05 2.05843559111303 0.692307692307692 12.3 12 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00104012640634339 0.00318301048650891 2.05843559111303 0.692307692307692 12.3 12 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00104012640634339 0.00318301048650891 2.05843559111303 0.692307692307692 12.3 12 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00104012640634339 0.00318301048650891 2.05843559111303 0.692307692307692 12.3 12 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.42451219638865e-18 1.57205918818137e-16 2.04827047708285 0.688888888888889 12.3 12 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 9.14773228239764e-13 1.69490685989137e-11 2.04718730919438 0.688524590163934 12.3 12 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 9.14773228239764e-13 1.69490685989137e-11 2.04718730919438 0.688524590163934 12.3 12 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 9.14773228239764e-13 1.69490685989137e-11 2.04718730919438 0.688524590163934 12.3 12 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000302975801582043 0.00102651087059821 2.04414089950808 0.6875 12.3 12 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000302975801582043 0.00102651087059821 2.04414089950808 0.6875 12.3 12 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000302975801582043 0.00102651087059821 2.04414089950808 0.6875 12.3 12 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000302975801582043 0.00102651087059821 2.04414089950808 0.6875 12.3 12 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000302975801582043 0.00102651087059821 2.04414089950808 0.6875 12.3 12 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.60582239545325e-11 2.99039134574998e-10 2.03725827021681 0.685185185185185 12.3 12 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.6764816295293e-15 2.51972109363678e-13 2.03650400947256 0.684931506849315 12.3 12 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 2.53317094099585e-08 1.9380119618479e-07 2.03436032104154 0.684210526315789 12.3 12 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 8.95417621960442e-05 0.000355915998896567 2.03436032104154 0.684210526315789 12.3 12 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 7.80193072871914e-09 6.20231699830577e-08 2.03054350993264 0.682926829268293 12.3 12 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 7.80193072871914e-09 6.20231699830577e-08 2.03054350993264 0.682926829268293 12.3 12 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.84755472869513e-13 1.55098199707405e-11 2.02939240816964 0.682539682539683 12.3 12 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.44397221373612e-10 6.8784236754198e-09 2.02437164516081 0.680851063829787 12.3 12 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 8.04825136516071e-06 4.00442716525304e-05 2.02184118060436 0.68 12.3 12 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 7.14606551834357e-11 7.21195122879639e-10 2.01959718373354 0.679245283018868 12.3 12 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.26556146899904e-07 1.38662568861242e-06 2.0113471952379 0.676470588235294 12.3 12 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 6.0248788197946e-11 6.16791551119979e-10 2.00021721075832 0.672727272727273 12.3 12 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 6.0248788197946e-11 6.16791551119979e-10 2.00021721075832 0.672727272727273 12.3 12 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 6.0248788197946e-11 6.16791551119979e-10 2.00021721075832 0.672727272727273 12.3 12 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 6.0248788197946e-11 6.16791551119979e-10 2.00021721075832 0.672727272727273 12.3 12 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 6.0248788197946e-11 6.16791551119979e-10 2.00021721075832 0.672727272727273 12.3 12 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 6.0248788197946e-11 6.16791551119979e-10 2.00021721075832 0.672727272727273 12.3 12 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.80753128793387e-12 3.02602002674106e-11 1.99768315179199 0.671875 12.3 12 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 5.62616880133208e-13 1.21893400064014e-11 1.99698975257235 0.671641791044776 12.3 12 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.88056023447243e-07 1.1584576682486e-06 1.98219723588662 0.666666666666667 12.3 12 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.88056023447243e-07 1.1584576682486e-06 1.98219723588662 0.666666666666667 12.3 12 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000246557374302588 0.000849518507584945 1.98219723588662 0.666666666666667 12.3 12 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.010338722645091 0.0248934049474864 1.98219723588662 0.666666666666667 12.3 12 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.010338722645091 0.0248934049474864 1.98219723588662 0.666666666666667 12.3 12 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.010338722645091 0.0248934049474864 1.98219723588662 0.666666666666667 12.3 12 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.010338722645091 0.0248934049474864 1.98219723588662 0.666666666666667 12.3 12 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.010338722645091 0.0248934049474864 1.98219723588662 0.666666666666667 12.3 12 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.010338722645091 0.0248934049474864 1.98219723588662 0.666666666666667 12.3 12 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.010338722645091 0.0248934049474864 1.98219723588662 0.666666666666667 12.3 12 3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.010338722645091 0.0248934049474864 1.98219723588662 0.666666666666667 12.3 12 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.56362175478095e-11 1.88562182801127e-10 1.98219723588662 0.666666666666667 12.3 12 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 5.23646350257087e-10 4.90229445010418e-09 1.98219723588662 0.666666666666667 12.3 12 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000839463335625311 0.00261390881092958 1.98219723588662 0.666666666666667 12.3 12 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000839463335625311 0.00261390881092958 1.98219723588662 0.666666666666667 12.3 12 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000839463335625311 0.00261390881092958 1.98219723588662 0.666666666666667 12.3 12 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0029075248652136 0.00814450370708455 1.98219723588662 0.666666666666667 12.3 12 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0029075248652136 0.00814450370708455 1.98219723588662 0.666666666666667 12.3 12 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0029075248652136 0.00814450370708455 1.98219723588662 0.666666666666667 12.3 12 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.62265517641244e-10 1.5924402179551e-09 1.98219723588662 0.666666666666667 12.3 12 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 6.63780410750583e-06 3.36142179536683e-05 1.98219723588662 0.666666666666667 12.3 12 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.29733462267353e-11 1.79233705637324e-10 1.96621177430689 0.661290322580645 12.3 12 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.29733462267353e-11 1.79233705637324e-10 1.96621177430689 0.661290322580645 12.3 12 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.17332395705081e-11 4.71320634197088e-10 1.96539895422657 0.661016949152542 12.3 12 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.34379677732049e-10 1.32793250981046e-09 1.96449904628049 0.660714285714286 12.3 12 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.5188561288585e-09 3.7604282288688e-08 1.96111003124953 0.659574468085106 12.3 12 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 4.74531652937009e-08 3.44519664351716e-07 1.95802409886362 0.658536585365854 12.3 12 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.32965079677975e-12 5.26454787090843e-11 1.95261220251518 0.656716417910448 12.3 12 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.1046155538536e-10 1.09920834484872e-09 1.94802142147479 0.655172413793103 12.3 12 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 5.39356850129608e-06 2.760808624944e-05 1.94802142147479 0.655172413793103 12.3 12 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 5.39356850129608e-06 2.760808624944e-05 1.94802142147479 0.655172413793103 12.3 12 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.52766058733246e-21 9.4515696338004e-20 1.94317760525894 0.653543307086614 12.3 12 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 8.51915029513081e-13 1.66065080410564e-11 1.94090146013899 0.652777777777778 12.3 12 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.19424041711757e-08 9.44113396421281e-08 1.93910599162822 0.652173913043478 12.3 12 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 5.89277699929109e-05 0.000245906793841385 1.93910599162822 0.652173913043478 12.3 12 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 9.01991376126622e-11 9.03896991709988e-10 1.93264230498946 0.65 12.3 12 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.2528543746995e-07 8.91405887598694e-07 1.93264230498946 0.65 12.3 12 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000196713427005649 0.000689466026179898 1.93264230498946 0.65 12.3 12 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000196713427005649 0.000689466026179898 1.93264230498946 0.65 12.3 12 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000196713427005649 0.000689466026179898 1.93264230498946 0.65 12.3 12 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000196713427005649 0.000689466026179898 1.93264230498946 0.65 12.3 12 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 6.95680037512554e-13 1.42587770328182e-11 1.92862433761942 0.648648648648649 12.3 12 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 6.95680037512554e-13 1.42587770328182e-11 1.92862433761942 0.648648648648649 12.3 12 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 4.07041450657093e-07 2.35455278164652e-06 1.92862433761942 0.648648648648649 12.3 12 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 4.07041450657093e-07 2.35455278164652e-06 1.92862433761942 0.648648648648649 12.3 12 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 9.3221691897205e-10 8.50349151087967e-09 1.92713620155644 0.648148148148148 12.3 12 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.000662785930190512 0.00211467349475583 1.92389731718408 0.647058823529412 12.3 12 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.000662785930190512 0.00211467349475583 1.92389731718408 0.647058823529412 12.3 12 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.67133252475389e-21 1.52052247308991e-19 1.9212065517055 0.646153846153846 12.3 12 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.42472486532834e-18 1.57205918818137e-16 1.91912732383569 0.645454545454546 12.3 12 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 5.65352382587838e-13 1.21893400064014e-11 1.91699337944299 0.644736842105263 12.3 12 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.80691171991484e-12 3.02602002674106e-11 1.91431376890421 0.643835616438356 12.3 12 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 5.77684201684105e-12 8.56296478121334e-11 1.9114044774621 0.642857142857143 12.3 12 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 1.41989891866444e-05 6.60299399104413e-05 1.9114044774621 0.642857142857143 12.3 12 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 1.41989891866444e-05 6.60299399104413e-05 1.9114044774621 0.642857142857143 12.3 12 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00226141634237664 0.00646183826345775 1.9114044774621 0.642857142857143 12.3 12 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00226141634237664 0.00646183826345775 1.9114044774621 0.642857142857143 12.3 12 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00226141634237664 0.00646183826345775 1.9114044774621 0.642857142857143 12.3 12 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 5.91112689346549e-11 6.16791551119979e-10 1.9047676563598 0.640625 12.3 12 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.85342684340212e-16 1.23043224186704e-14 1.90290934645116 0.64 12.3 12 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 7.78240801891208e-09 6.20231699830577e-08 1.90290934645116 0.64 12.3 12 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.65885661729924e-12 6.97847680675455e-11 1.89960568439135 0.638888888888889 12.3 12 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 6.05904777463777e-10 5.63531044660754e-09 1.89675769985703 0.637931034482759 12.3 12 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.48731423666179e-11 1.80893005023053e-10 1.89601474736981 0.63768115942029 12.3 12 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000154757986923337 0.000551931366897014 1.89209736152814 0.636363636363636 12.3 12 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000154757986923337 0.000551931366897014 1.89209736152814 0.636363636363636 12.3 12 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.000154757986923337 0.000551931366897014 1.89209736152814 0.636363636363636 12.3 12 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00785631684248916 0.0194426762901949 1.89209736152814 0.636363636363636 12.3 12 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00785631684248916 0.0194426762901949 1.89209736152814 0.636363636363636 12.3 12 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00785631684248916 0.0194426762901949 1.89209736152814 0.636363636363636 12.3 12 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00785631684248916 0.0194426762901949 1.89209736152814 0.636363636363636 12.3 12 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00785631684248916 0.0194426762901949 1.89209736152814 0.636363636363636 12.3 12 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00785631684248916 0.0194426762901949 1.89209736152814 0.636363636363636 12.3 12 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00785631684248916 0.0194426762901949 1.89209736152814 0.636363636363636 12.3 12 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00785631684248916 0.0194426762901949 1.89209736152814 0.636363636363636 12.3 12 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 6.22395710187351e-09 5.09005227354368e-08 1.88689929185361 0.634615384615385 12.3 12 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.60194709242113e-07 1.56226612342417e-06 1.88550468779459 0.634146341463415 12.3 12 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.60194709242113e-07 1.56226612342417e-06 1.88550468779459 0.634146341463415 12.3 12 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.60194709242113e-07 1.56226612342417e-06 1.88550468779459 0.634146341463415 12.3 12 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.60194709242113e-07 1.56226612342417e-06 1.88550468779459 0.634146341463415 12.3 12 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.19214156179269e-11 1.71355297215252e-10 1.88448328763869 0.633802816901408 12.3 12 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 9.40953211042997e-13 1.69490685989137e-11 1.88183281887971 0.632911392405063 12.3 12 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.51071232890478e-23 1.13144402317448e-21 1.87989028177635 0.632258064516129 12.3 12 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.37680114316374e-20 1.25266223211926e-18 1.8778710655768 0.631578947368421 12.3 12 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.99271470388252e-12 4.95189886468004e-11 1.8778710655768 0.631578947368421 12.3 12 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.36632606246056e-13 5.52013440472357e-12 1.87600809824984 0.630952380952381 12.3 12 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.36632606246056e-13 5.52013440472357e-12 1.87600809824984 0.630952380952381 12.3 12 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 9.51772570173201e-12 1.39626017253244e-10 1.87358368871475 0.63013698630137 12.3 12 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 3.67166083121251e-05 0.000158184764124611 1.87207516722626 0.62962962962963 12.3 12 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 3.67166083121251e-05 0.000158184764124611 1.87207516722626 0.62962962962963 12.3 12 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 3.67166083121251e-05 0.000158184764124611 1.87207516722626 0.62962962962963 12.3 12 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 2.7185422808717e-06 1.4653354794244e-05 1.86892882240739 0.628571428571429 12.3 12 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 6.17570151757225e-38 1.25543189421504e-35 1.86827785451383 0.628352490421456 12.3 12 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 6.16301291983715e-25 5.84664492328551e-23 1.86490745861523 0.627218934911243 12.3 12 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.99293838842197e-16 1.25263274315425e-14 1.86178338510847 0.626168224299065 12.3 12 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.4025680618973e-11 2.77955638380476e-10 1.85830990864371 0.625 12.3 12 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 5.0658564797111e-08 3.65924556884716e-07 1.85830990864371 0.625 12.3 12 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000120504798824062 0.000445398256432833 1.85830990864371 0.625 12.3 12 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000120504798824062 0.000445398256432833 1.85830990864371 0.625 12.3 12 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000120504798824062 0.000445398256432833 1.85830990864371 0.625 12.3 12 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000120504798824062 0.000445398256432833 1.85830990864371 0.625 12.3 12 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00173360922569742 0.00506555632067235 1.85830990864371 0.625 12.3 12 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00173360922569742 0.00506555632067235 1.85830990864371 0.625 12.3 12 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00173360922569742 0.00506555632067235 1.85830990864371 0.625 12.3 12 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00173360922569742 0.00506555632067235 1.85830990864371 0.625 12.3 12 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00173360922569742 0.00506555632067235 1.85830990864371 0.625 12.3 12 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0280655861491124 0.0600125387105749 1.85830990864371 0.625 12.3 12 3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.0280655861491124 0.0600125387105749 1.85830990864371 0.625 12.3 12 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0280655861491124 0.0600125387105749 1.85830990864371 0.625 12.3 12 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0280655861491124 0.0600125387105749 1.85830990864371 0.625 12.3 12 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0280655861491124 0.0600125387105749 1.85830990864371 0.625 12.3 12 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.23284567973024e-24 1.03196435426832e-22 1.85393741474102 0.623529411764706 12.3 12 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.62125709646264e-07 1.01186352994137e-06 1.85005075349418 0.622222222222222 12.3 12 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.50080124482343e-12 2.66955021422967e-11 1.84924498226008 0.621951219512195 12.3 12 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 6.10164465080175e-41 1.44710672301515e-38 1.84689367029709 0.621160409556314 12.3 12 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.9791769187655e-14 7.70794319164238e-13 1.84657321448386 0.621052631578947 12.3 12 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.9791769187655e-14 7.70794319164238e-13 1.84657321448386 0.621052631578947 12.3 12 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 3.75465850051251e-13 8.48076039084016e-12 1.84549397823927 0.620689655172414 12.3 12 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 3.75465850051251e-13 8.48076039084016e-12 1.84549397823927 0.620689655172414 12.3 12 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 2.86078593990324e-05 0.000126819264563312 1.84549397823927 0.620689655172414 12.3 12 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 2.86078593990324e-05 0.000126819264563312 1.84549397823927 0.620689655172414 12.3 12 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.05860371878969e-23 2.07256813897034e-21 1.84234896464309 0.619631901840491 12.3 12 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000397273071974011 0.0013091768040354 1.84061171903758 0.619047619047619 12.3 12 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000397273071974011 0.0013091768040354 1.84061171903758 0.619047619047619 12.3 12 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000397273071974011 0.0013091768040354 1.84061171903758 0.619047619047619 12.3 12 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 6.86774588053719e-06 3.44112760141001e-05 1.83644743913025 0.617647058823529 12.3 12 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 6.86774588053719e-06 3.44112760141001e-05 1.83644743913025 0.617647058823529 12.3 12 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 9.33618281688852e-13 1.69490685989137e-11 1.83238000294171 0.616279069767442 12.3 12 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 9.33618281688852e-13 1.69490685989137e-11 1.83238000294171 0.616279069767442 12.3 12 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.85505009971657e-14 4.98063451301262e-13 1.83203077862249 0.616161616161616 12.3 12 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 3.12124239177436e-08 2.35001477433593e-07 1.82972052543381 0.615384615384615 12.3 12 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 9.31098888993595e-05 0.000365304235844409 1.82972052543381 0.615384615384615 12.3 12 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 9.31098888993595e-05 0.000365304235844409 1.82972052543381 0.615384615384615 12.3 12 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 9.31098888993595e-05 0.000365304235844409 1.82972052543381 0.615384615384615 12.3 12 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00589536239940594 0.0151427810367412 1.82972052543381 0.615384615384615 12.3 12 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00589536239940594 0.0151427810367412 1.82972052543381 0.615384615384615 12.3 12 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00589536239940594 0.0151427810367412 1.82972052543381 0.615384615384615 12.3 12 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.33606116165026e-13 1.47031197648286e-11 1.82452245575928 0.613636363636364 12.3 12 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00131685937515725 0.00394503345441845 1.81701413289607 0.611111111111111 12.3 12 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00131685937515725 0.00394503345441845 1.81701413289607 0.611111111111111 12.3 12 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00131685937515725 0.00394503345441845 1.81701413289607 0.611111111111111 12.3 12 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00131685937515725 0.00394503345441845 1.81701413289607 0.611111111111111 12.3 12 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.86524242470434e-15 9.06053326745395e-14 1.81701413289607 0.611111111111111 12.3 12 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 8.21495783582287e-56 2.92247125009398e-53 1.81468761031874 0.610328638497653 12.3 12 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.80367942512395e-12 3.02602002674106e-11 1.81131816382743 0.609195402298851 12.3 12 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.67858835334356e-10 3.48975415120525e-09 1.80983225885301 0.608695652173913 12.3 12 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 3.14609113357846e-07 1.85762974401749e-06 1.80983225885301 0.608695652173913 12.3 12 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 7.15165651424131e-05 0.000287480429936875 1.80521533982532 0.607142857142857 12.3 12 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.70639625768273e-05 7.83290927316944e-05 1.80199748716966 0.606060606060606 12.3 12 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 5.47740793991755e-15 1.65837265925589e-13 1.80034427846583 0.605504587155963 12.3 12 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.369898230432e-15 4.99837226129419e-14 1.79962643784444 0.605263157894737 12.3 12 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 3.42752118216557e-16 1.39353218349189e-14 1.79896891996433 0.605042016806723 12.3 12 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.26938213839567e-15 1.32072408324718e-13 1.7946920919514 0.603603603603604 12.3 12 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.37492062378919e-11 1.80893005023053e-10 1.79114208062044 0.602409638554217 12.3 12 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 9.67850012653001e-27 1.14770880667102e-24 1.78397751229796 0.6 12.3 12 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.62848907365869e-13 1.40781193310691e-11 1.78397751229796 0.6 12.3 12 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 4.61616090310269e-08 3.38597781706965e-07 1.78397751229796 0.6 12.3 12 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.88028129746391e-07 1.1584576682486e-06 1.78397751229796 0.6 12.3 12 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 1.30915512800355e-05 6.16863492433461e-05 1.78397751229796 0.6 12.3 12 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 1.30915512800355e-05 6.16863492433461e-05 1.78397751229796 0.6 12.3 12 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 1.30915512800355e-05 6.16863492433461e-05 1.78397751229796 0.6 12.3 12 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.46764225291429e-05 0.000228836909585207 1.78397751229796 0.6 12.3 12 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000231134197808 0.000800252952507992 1.78397751229796 0.6 12.3 12 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000231134197808 0.000800252952507992 1.78397751229796 0.6 12.3 12 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00439434585250363 0.0114736773359865 1.78397751229796 0.6 12.3 12 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00439434585250363 0.0114736773359865 1.78397751229796 0.6 12.3 12 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00439434585250363 0.0114736773359865 1.78397751229796 0.6 12.3 12 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00439434585250363 0.0114736773359865 1.78397751229796 0.6 12.3 12 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00439434585250363 0.0114736773359865 1.78397751229796 0.6 12.3 12 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00439434585250363 0.0114736773359865 1.78397751229796 0.6 12.3 12 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.16247772645619e-06 1.68547033885661e-05 1.78397751229796 0.6 12.3 12 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0203738836101385 0.04501869002675 1.78397751229796 0.6 12.3 12 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.88774755750137e-16 1.45585915113801e-14 1.77438623535012 0.596774193548387 12.3 12 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.88774755750137e-16 1.45585915113801e-14 1.77438623535012 0.596774193548387 12.3 12 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.88774755750137e-16 1.45585915113801e-14 1.77438623535012 0.596774193548387 12.3 12 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 9.93593643378402e-14 2.48049781496047e-12 1.772541759014 0.596153846153846 12.3 12 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.44751629031984e-07 9.11422867754483e-07 1.772541759014 0.596153846153846 12.3 12 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.44751629031984e-07 9.11422867754483e-07 1.772541759014 0.596153846153846 12.3 12 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 2.42495037728833e-06 1.31205489995486e-05 1.76981896061306 0.595238095238095 12.3 12 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 4.1647868075336e-05 0.000176383679378581 1.76539441321152 0.59375 12.3 12 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.45739740424519e-20 2.18719879525548e-18 1.76539441321152 0.59375 12.3 12 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000175136478844428 0.00061994828207866 1.76195309856589 0.592592592592593 12.3 12 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 4.53072576376153e-07 2.61021164446667e-06 1.75970570940955 0.591836734693878 12.3 12 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.80583966315211e-12 5.88664113115811e-11 1.75840077377039 0.591397849462366 12.3 12 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.19656540744152e-26 1.30977890368407e-24 1.75694754999042 0.590909090909091 12.3 12 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.57846092703009e-14 1.16341962485068e-12 1.75694754999042 0.590909090909091 12.3 12 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000747572639269431 0.00234833524432759 1.75694754999042 0.590909090909091 12.3 12 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000747572639269431 0.00234833524432759 1.75694754999042 0.590909090909091 12.3 12 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000747572639269431 0.00234833524432759 1.75694754999042 0.590909090909091 12.3 12 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.05351671685618e-61 9.74051429362114e-59 1.75232265149673 0.5893536121673 12.3 12 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.40965263748066e-13 3.45850983299135e-12 1.75063213823632 0.588785046728972 12.3 12 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00326335679070729 0.00898212130208217 1.74899756107643 0.588235294117647 12.3 12 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00326335679070729 0.00898212130208217 1.74899756107643 0.588235294117647 12.3 12 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00326335679070729 0.00898212130208217 1.74899756107643 0.588235294117647 12.3 12 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00326335679070729 0.00898212130208217 1.74899756107643 0.588235294117647 12.3 12 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00326335679070729 0.00898212130208217 1.74899756107643 0.588235294117647 12.3 12 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00326335679070729 0.00898212130208217 1.74899756107643 0.588235294117647 12.3 12 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 4.70716241591781e-11 5.19247450996204e-10 1.74899756107643 0.588235294117647 12.3 12 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 4.70716241591781e-11 5.19247450996204e-10 1.74899756107643 0.588235294117647 12.3 12 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 4.70716241591781e-11 5.19247450996204e-10 1.74899756107643 0.588235294117647 12.3 12 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.33219570175439e-13 9.63236638061952e-12 1.7439523758041 0.586538461538462 12.3 12 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.73158083518445e-12 3.00492625422863e-11 1.741930904264 0.585858585858586 12.3 12 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 8.22137668182222e-25 7.31188688639563e-23 1.74150185724325 0.585714285714286 12.3 12 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.33821461044644e-09 2.05387616707734e-08 1.7344225814008 0.583333333333333 12.3 12 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.07748332545385e-06 6.01277949851305e-06 1.7344225814008 0.583333333333333 12.3 12 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0147846256106749 0.0343205909363628 1.7344225814008 0.583333333333333 12.3 12 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0147846256106749 0.0343205909363628 1.7344225814008 0.583333333333333 12.3 12 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0147846256106749 0.0343205909363628 1.7344225814008 0.583333333333333 12.3 12 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0147846256106749 0.0343205909363628 1.7344225814008 0.583333333333333 12.3 12 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0147846256106749 0.0343205909363628 1.7344225814008 0.583333333333333 12.3 12 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0147846256106749 0.0343205909363628 1.7344225814008 0.583333333333333 12.3 12 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0147846256106749 0.0343205909363628 1.7344225814008 0.583333333333333 12.3 12 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0147846256106749 0.0343205909363628 1.7344225814008 0.583333333333333 12.3 12 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.81710706334699e-15 5.87668943441536e-14 1.72866038013368 0.581395348837209 12.3 12 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 4.40694019203606e-06 2.28039123391539e-05 1.72866038013368 0.581395348837209 12.3 12 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.49789404585328e-13 3.6127173343207e-12 1.72557348659773 0.580357142857143 12.3 12 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.81202139530058e-05 8.23803976202148e-05 1.72138181011207 0.578947368421053 12.3 12 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00241841639779555 0.00685539150211768 1.72138181011207 0.578947368421053 12.3 12 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00241841639779555 0.00685539150211768 1.72138181011207 0.578947368421053 12.3 12 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00241841639779555 0.00685539150211768 1.72138181011207 0.578947368421053 12.3 12 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.15848425279927e-20 2.11340110419048e-18 1.71342472932573 0.576271186440678 12.3 12 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.36790918351857e-05 6.40307489522016e-05 1.70964511595221 0.575 12.3 12 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.85175156801682e-20 1.01347787741844e-18 1.70598942432865 0.573770491803279 12.3 12 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 3.16725464492908e-09 2.66686589333378e-08 1.7046896228625 0.573333333333333 12.3 12 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 3.16725464492908e-09 2.66686589333378e-08 1.7046896228625 0.573333333333333 12.3 12 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 3.16725464492908e-09 2.66686589333378e-08 1.7046896228625 0.573333333333333 12.3 12 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 3.16725464492908e-09 2.66686589333378e-08 1.7046896228625 0.573333333333333 12.3 12 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 3.16725464492908e-09 2.66686589333378e-08 1.7046896228625 0.573333333333333 12.3 12 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.91003099089077e-06 1.04136938698758e-05 1.69902620218854 0.571428571428571 12.3 12 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 3.56847316858266e-07 2.09832120615418e-06 1.69902620218854 0.571428571428571 12.3 12 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000313296363780447 0.00105644721720279 1.69902620218854 0.571428571428571 12.3 12 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000313296363780447 0.00105644721720279 1.69902620218854 0.571428571428571 12.3 12 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0107406238087783 0.0256441404025027 1.69902620218854 0.571428571428571 12.3 12 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0107406238087783 0.0256441404025027 1.69902620218854 0.571428571428571 12.3 12 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0107406238087783 0.0256441404025027 1.69902620218854 0.571428571428571 12.3 12 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0107406238087783 0.0256441404025027 1.69902620218854 0.571428571428571 12.3 12 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0107406238087783 0.0256441404025027 1.69902620218854 0.571428571428571 12.3 12 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 3.84696222180457e-08 2.88117223243574e-07 1.6863469021722 0.567164179104478 12.3 12 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000233816751182358 0.00080757581779732 1.68486765050363 0.566666666666667 12.3 12 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.1565616580206e-09 2.66686589333378e-08 1.67247891777934 0.5625 12.3 12 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.16210038547398e-07 8.3098937112034e-07 1.67247891777934 0.5625 12.3 12 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00781529294411163 0.0194426762901949 1.67247891777934 0.5625 12.3 12 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00781529294411163 0.0194426762901949 1.67247891777934 0.5625 12.3 12 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00781529294411163 0.0194426762901949 1.67247891777934 0.5625 12.3 12 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00781529294411163 0.0194426762901949 1.67247891777934 0.5625 12.3 12 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.37400639368337e-05 0.000106233053402875 1.66794645458753 0.560975609756098 12.3 12 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000129961960789859 0.000472981765227544 1.66154768302261 0.558823529411765 12.3 12 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 1.77719369013715e-05 8.10559814443964e-05 1.65951396492834 0.558139534883721 12.3 12 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 7.12671938494731e-09 5.76211459362501e-08 1.65601288061414 0.556962025316456 12.3 12 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 7.12671938494731e-09 5.76211459362501e-08 1.65601288061414 0.556962025316456 12.3 12 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 9.68277319987512e-05 0.000367428967024595 1.65183102990552 0.555555555555556 12.3 12 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00569647856014486 0.0147115952651291 1.65183102990552 0.555555555555556 12.3 12 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0502241655291393 0.0998170217150352 1.65183102990552 0.555555555555556 12.3 12 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0502241655291393 0.0998170217150352 1.65183102990552 0.555555555555556 12.3 12 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0502241655291393 0.0998170217150352 1.65183102990552 0.555555555555556 12.3 12 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0502241655291393 0.0998170217150352 1.65183102990552 0.555555555555556 12.3 12 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0502241655291393 0.0998170217150352 1.65183102990552 0.555555555555556 12.3 12 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0502241655291393 0.0998170217150352 1.65183102990552 0.555555555555556 12.3 12 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0502241655291393 0.0998170217150352 1.65183102990552 0.555555555555556 12.3 12 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000724615021573074 0.00230162316004126 1.65183102990552 0.555555555555556 12.3 12 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000724615021573074 0.00230162316004126 1.65183102990552 0.555555555555556 12.3 12 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.09752187955735e-21 7.0989710664096e-20 1.6399793274488 0.551569506726457 12.3 12 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.4949661801131e-10 2.39887626641956e-09 1.63834669496752 0.551020408163265 12.3 12 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.87841569645886e-10 1.83081201100066e-09 1.63531271960647 0.55 12.3 12 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 5.37103246548475e-05 0.000225456613521675 1.63531271960646 0.55 12.3 12 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 5.37103246548475e-05 0.000225456613521675 1.63531271960646 0.55 12.3 12 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00415906745971623 0.0111038517733137 1.63531271960646 0.55 12.3 12 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000396657558450412 0.0013091768040354 1.63051708113255 0.548387096774194 12.3 12 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 4.70427241067047e-08 3.4329126360944e-07 1.62540173342703 0.546666666666667 12.3 12 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 8.81270690604098e-18 3.9189006022801e-16 1.62179773845269 0.545454545454545 12.3 12 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 3.103972311112e-06 1.66050849575653e-05 1.62179773845269 0.545454545454545 12.3 12 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000293593657520172 0.0010067078907258 1.62179773845269 0.545454545454545 12.3 12 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00304138153703661 0.00848605083765312 1.62179773845269 0.545454545454545 12.3 12 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00304138153703661 0.00848605083765312 1.62179773845269 0.545454545454545 12.3 12 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0353949637313176 0.0740691667495073 1.62179773845269 0.545454545454545 12.3 12 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0353949637313176 0.0740691667495073 1.62179773845269 0.545454545454545 12.3 12 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0353949637313176 0.0740691667495073 1.62179773845269 0.545454545454545 12.3 12 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0353949637313176 0.0740691667495073 1.62179773845269 0.545454545454545 12.3 12 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0353949637313176 0.0740691667495073 1.62179773845269 0.545454545454545 12.3 12 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0353949637313176 0.0740691667495073 1.62179773845269 0.545454545454545 12.3 12 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0353949637313176 0.0740691667495073 1.62179773845269 0.545454545454545 12.3 12 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 4.96171087978741e-48 1.4121029163875e-45 1.6202792012444 0.544943820224719 12.3 12 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.72744863587419e-12 5.82874660313073e-11 1.61960018054151 0.544715447154472 12.3 12 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.64592662549515e-08 2.0134511166201e-07 1.61837622423655 0.544303797468354 12.3 12 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.21734431006342e-05 9.95356767577365e-05 1.61592165969018 0.543478260869565 12.3 12 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.98376853985109e-08 1.52589331470708e-07 1.6151236736854 0.54320987654321 12.3 12 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.98376853985109e-08 1.52589331470708e-07 1.6151236736854 0.54320987654321 12.3 12 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.58731196299129e-15 5.42941884657749e-14 1.61355689628576 0.542682926829268 12.3 12 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.73229128409634e-06 9.48096345103495e-06 1.61263503936539 0.542372881355932 12.3 12 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.73229128409634e-06 9.48096345103495e-06 1.61263503936539 0.542372881355932 12.3 12 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.10301282673756e-23 8.71992918026412e-22 1.61244121303854 0.542307692307692 12.3 12 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.3806186767087e-07 8.93009262252944e-07 1.61053525415788 0.541666666666667 12.3 12 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00222730717444312 0.00640294567521729 1.61053525415788 0.541666666666667 12.3 12 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00222730717444312 0.00640294567521729 1.61053525415788 0.541666666666667 12.3 12 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.00222730717444312 0.00640294567521729 1.61053525415788 0.541666666666667 12.3 12 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00163332171530037 0.00482202655782661 1.60100545975458 0.538461538461538 12.3 12 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00163332171530037 0.00482202655782661 1.60100545975458 0.538461538461538 12.3 12 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00163332171530037 0.00482202655782661 1.60100545975458 0.538461538461538 12.3 12 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0251554326904888 0.0544842933311499 1.60100545975458 0.538461538461538 12.3 12 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0251554326904888 0.0544842933311499 1.60100545975458 0.538461538461538 12.3 12 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0251554326904888 0.0544842933311499 1.60100545975458 0.538461538461538 12.3 12 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0251554326904888 0.0544842933311499 1.60100545975458 0.538461538461538 12.3 12 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0251554326904888 0.0544842933311499 1.60100545975458 0.538461538461538 12.3 12 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.76887345907074e-14 4.84059025434165e-13 1.60100545975458 0.538461538461538 12.3 12 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 7.21776140491108e-07 4.0757438409478e-06 1.60100545975458 0.538461538461538 12.3 12 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.32829412998104e-14 3.78032509392604e-13 1.59955789604775 0.537974683544304 12.3 12 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 5.39039366558625e-07 3.06821207445169e-06 1.59759180205788 0.537313432835821 12.3 12 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 5.39039366558625e-07 3.06821207445169e-06 1.59759180205788 0.537313432835821 12.3 12 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.7681595615875e-11 2.07941409598265e-10 1.59722504544583 0.537190082644628 12.3 12 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.7681595615875e-11 2.07941409598265e-10 1.59722504544583 0.537190082644628 12.3 12 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 2.42446094007736e-28 3.13637083430007e-26 1.59609440006208 0.53680981595092 12.3 12 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 8.8412731802021e-05 0.000352412653653434 1.5954270435185 0.536585365853659 12.3 12 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 8.8412731802021e-05 0.000352412653653434 1.5954270435185 0.536585365853659 12.3 12 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 4.02556004741084e-07 2.35215901217861e-06 1.59437603756098 0.536231884057971 12.3 12 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00119921347287226 0.00364632643567784 1.59283706455175 0.535714285714286 12.3 12 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 6.55506621897869e-05 0.000271158698535078 1.59036754972299 0.534883720930233 12.3 12 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.78202776232792e-06 1.97136465413649e-05 1.58917537015048 0.53448275862069 12.3 12 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.78202776232792e-06 1.97136465413649e-05 1.58917537015048 0.53448275862069 12.3 12 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 3.78202776232792e-06 1.97136465413649e-05 1.58917537015048 0.53448275862069 12.3 12 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 3.78202776232792e-06 1.97136465413649e-05 1.58917537015048 0.53448275862069 12.3 12 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 3.78202776232792e-06 1.97136465413649e-05 1.58917537015048 0.53448275862069 12.3 12 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.1926440447505e-12 6.34694944221272e-11 1.58878404403126 0.534351145038168 12.3 12 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.1926440447505e-12 6.34694944221272e-11 1.58878404403126 0.534351145038168 12.3 12 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000881472972907696 0.00273872497914334 1.5857577887093 0.533333333333333 12.3 12 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0179935129016637 0.0405138747770054 1.5857577887093 0.533333333333333 12.3 12 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0179935129016637 0.0405138747770054 1.5857577887093 0.533333333333333 12.3 12 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0179935129016637 0.0405138747770054 1.5857577887093 0.533333333333333 12.3 12 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.8555689933799e-11 3.25077974206368e-10 1.58413303687661 0.532786885245902 12.3 12 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.20151842764656e-23 1.56638036127053e-21 1.57788624733935 0.530685920577617 12.3 12 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.87704786178327e-72 5.5170391073176e-69 1.57746126181701 0.530542986425339 12.3 12 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.8941863229266e-08 2.90127075263066e-07 1.57409780496879 0.529411764705882 12.3 12 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000477679316341773 0.00155191248208754 1.57409780496879 0.529411764705882 12.3 12 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000477679316341773 0.00155191248208754 1.57409780496879 0.529411764705882 12.3 12 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000477679316341773 0.00155191248208754 1.57409780496879 0.529411764705882 12.3 12 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0129362211166915 0.0305277655871509 1.57409780496879 0.529411764705882 12.3 12 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0129362211166915 0.0305277655871509 1.57409780496879 0.529411764705882 12.3 12 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00933876985164407 0.0227942873051278 1.56489255464734 0.526315789473684 12.3 12 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00933876985164407 0.0227942873051278 1.56489255464734 0.526315789473684 12.3 12 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 4.49818158070369e-06 2.31917115555846e-05 1.5597617593862 0.524590163934426 12.3 12 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.000141672676975407 0.000509091462969706 1.55744068533949 0.523809523809524 12.3 12 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0067648073133241 0.017159217124528 1.55744068533949 0.523809523809524 12.3 12 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0067648073133241 0.017159217124528 1.55744068533949 0.523809523809524 12.3 12 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0067648073133241 0.017159217124528 1.55744068533949 0.523809523809524 12.3 12 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0067648073133241 0.017159217124528 1.55744068533949 0.523809523809524 12.3 12 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0067648073133241 0.017159217124528 1.55744068533949 0.523809523809524 12.3 12 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0067648073133241 0.017159217124528 1.55744068533949 0.523809523809524 12.3 12 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0049144068213504 0.0127613155233241 1.55128479330258 0.521739130434783 12.3 12 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0049144068213504 0.0127613155233241 1.55128479330258 0.521739130434783 12.3 12 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 3.14444424875363e-05 0.000138530779132397 1.54382669333477 0.519230769230769 12.3 12 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00261192892392978 0.00737455329117474 1.54170896124515 0.518518518518518 12.3 12 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 9.508540013005e-06 4.60226273418575e-05 1.53620285781213 0.516666666666667 12.3 12 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 9.508540013005e-06 4.60226273418575e-05 1.53620285781213 0.516666666666667 12.3 12 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 9.508540013005e-06 4.60226273418575e-05 1.53620285781213 0.516666666666667 12.3 12 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 9.508540013005e-06 4.60226273418575e-05 1.53620285781213 0.516666666666667 12.3 12 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 9.508540013005e-06 4.60226273418575e-05 1.53620285781213 0.516666666666667 12.3 12 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 9.508540013005e-06 4.60226273418575e-05 1.53620285781213 0.516666666666667 12.3 12 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 9.508540013005e-06 4.60226273418575e-05 1.53620285781213 0.516666666666667 12.3 12 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00139860941499547 0.00415495030801368 1.53460431165416 0.516129032258065 12.3 12 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000753291778088839 0.00236108854674101 1.52912358196968 0.514285714285714 12.3 12 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.000553838398506218 0.00178710213395544 1.52682760061537 0.513513513513513 12.3 12 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 8.82926945166996e-07 4.94647654713636e-06 1.52577024078115 0.513157894736842 12.3 12 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.089041527726e-05 5.21786563620908e-05 1.51024551305648 0.507936507936508 12.3 12 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 8.0594063968523e-15 2.38927818806684e-13 1.48664792691497 0.5 12.3 12 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 7.94041773516697e-08 5.70667395815283e-07 1.48664792691497 0.5 12.3 12 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 6.75270918082671e-06 3.40748410082142e-05 1.48664792691497 0.5 12.3 12 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000135874579956453 0.000489492474121601 1.48664792691497 0.5 12.3 12 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00552456243766039 0.0142935497250741 1.48664792691497 0.5 12.3 12 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0201759636732382 0.04501869002675 1.48664792691497 0.5 12.3 12 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0201759636732382 0.04501869002675 1.48664792691497 0.5 12.3 12 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0201759636732382 0.04501869002675 1.48664792691497 0.5 12.3 12 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0395702415721991 0.0812531800248763 1.48664792691497 0.5 12.3 12 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0395702415721991 0.0812531800248763 1.48664792691497 0.5 12.3 12 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0395702415721991 0.0812531800248763 1.48664792691497 0.5 12.3 12 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0395702415721991 0.0812531800248763 1.48664792691497 0.5 12.3 12 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0395702415721991 0.0812531800248763 1.48664792691497 0.5 12.3 12 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0560053018519602 0.109022632743282 1.48664792691497 0.5 12.3 12 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0560053018519602 0.109022632743282 1.48664792691497 0.5 12.3 12 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0281717328592158 0.0600125387105749 1.48664792691497 0.5 12.3 12 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0281717328592158 0.0600125387105749 1.48664792691497 0.5 12.3 12 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0281717328592158 0.0600125387105749 1.48664792691497 0.5 12.3 12 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0281717328592158 0.0600125387105749 1.48664792691497 0.5 12.3 12 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0281717328592158 0.0600125387105749 1.48664792691497 0.5 12.3 12 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0800744474481402 0.14817417258609 1.48664792691497 0.5 12.3 12 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0800744474481402 0.14817417258609 1.48664792691497 0.5 12.3 12 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0800744474481402 0.14817417258609 1.48664792691497 0.5 12.3 12 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0800744474481402 0.14817417258609 1.48664792691497 0.5 12.3 12 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0800744474481402 0.14817417258609 1.48664792691497 0.5 12.3 12 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0800744474481402 0.14817417258609 1.48664792691497 0.5 12.3 12 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.46469204418258e-63 1.04212838943591e-60 1.47325470234817 0.495495495495495 12.3 12 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.26332598876291e-06 6.96787938763421e-06 1.4691579513042 0.494117647058824 12.3 12 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.15395469282593e-09 1.90377486204428e-08 1.46412295832535 0.492424242424242 12.3 12 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.47463648135384e-05 0.000110388956519327 1.46377642034705 0.492307692307692 12.3 12 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.000111026166835883 0.000417963585734027 1.45961796460742 0.490909090909091 12.3 12 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000203131918307894 0.000708472352333661 1.45749796756369 0.490196078431373 12.3 12 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.3759462288074e-08 1.08175220088007e-07 1.45038822138046 0.48780487804878 12.3 12 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.93936096764182e-09 1.73566707984548e-08 1.44417227186025 0.485714285714286 12.3 12 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 2.00970256657456e-05 9.05002136783418e-05 1.44417227186025 0.485714285714286 12.3 12 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00234882985377209 0.00669816609602743 1.44417227186025 0.485714285714286 12.3 12 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00320544662812961 0.00892632201923373 1.44159798973573 0.484848484848485 12.3 12 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.04606310644089e-10 1.98064476222135e-09 1.43989799210632 0.484276729559748 12.3 12 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 5.13920799942694e-29 7.31309298318454e-27 1.43830165286895 0.483739837398374 12.3 12 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.78551659806048e-09 3.16870007002356e-08 1.43317138278134 0.482014388489209 12.3 12 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00822915070041028 0.0203300025116039 1.43158689258478 0.481481481481481 12.3 12 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 9.53911854652151e-10 8.64596540872618e-09 1.42796445611569 0.480263157894737 12.3 12 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0113146428298983 0.0268793601785397 1.42718200983837 0.48 12.3 12 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0113146428298983 0.0268793601785397 1.42718200983837 0.48 12.3 12 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0113146428298983 0.0268793601785397 1.42718200983837 0.48 12.3 12 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000546157278793768 0.00176632229028075 1.42470426329351 0.479166666666667 12.3 12 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 5.47993340954061e-09 4.50748279871462e-08 1.4229344443329 0.478571428571429 12.3 12 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.000739823647880826 0.00233948677985426 1.42201106052736 0.478260869565217 12.3 12 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.000739823647880826 0.00233948677985426 1.42201106052736 0.478260869565217 12.3 12 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0155975738355177 0.0360899960454336 1.42201106052736 0.478260869565217 12.3 12 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0155975738355177 0.0360899960454336 1.42201106052736 0.478260869565217 12.3 12 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 7.69406643887487e-10 7.06364938227029e-09 1.42036426138373 0.477707006369427 12.3 12 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00100291534922861 0.00310249683033111 1.41907302114611 0.477272727272727 12.3 12 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00100291534922861 0.00310249683033111 1.41907302114611 0.477272727272727 12.3 12 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.87209618527348e-11 5.29236097072073e-10 1.41353409444374 0.475409836065574 12.3 12 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000175120602956113 0.00061994828207866 1.41105565944472 0.474576271186441 12.3 12 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.73472176702176e-05 7.93732821373624e-05 1.41040957168856 0.474358974358974 12.3 12 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.53316513621993e-15 5.42941884657749e-14 1.41012928361787 0.474264705882353 12.3 12 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.18868762463109e-11 2.5528708933197e-10 1.40921834738815 0.473958333333333 12.3 12 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00251150990172628 0.0071051264217823 1.4084032991826 0.473684210526316 12.3 12 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00341746626640537 0.00937004720056811 1.40405637541969 0.472222222222222 12.3 12 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00341746626640537 0.00937004720056811 1.40405637541969 0.472222222222222 12.3 12 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0417144099636818 0.0850022983148953 1.39919804886115 0.470588235294118 12.3 12 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0417144099636818 0.0850022983148953 1.39919804886115 0.470588235294118 12.3 12 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0417144099636818 0.0850022983148953 1.39919804886115 0.470588235294118 12.3 12 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000102502243219377 0.000387927372609504 1.39654805255649 0.46969696969697 12.3 12 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 1.84459397812526e-05 8.33288009800711e-05 1.39487953636466 0.469135802469136 12.3 12 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.84459397812526e-05 8.33288009800711e-05 1.39487953636466 0.469135802469136 12.3 12 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.60013024076675e-08 1.251090842094e-07 1.39308267277347 0.468531468531469 12.3 12 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 7.01415595430272e-13 1.42587770328182e-11 1.39094097883031 0.467811158798283 12.3 12 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 6.03773417799128e-06 3.06846276260057e-05 1.38969262733356 0.467391304347826 12.3 12 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0584498791589176 0.113162146997469 1.38753806512064 0.466666666666667 12.3 12 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 8.08893105047079e-06 4.01064421073865e-05 1.38753806512064 0.466666666666667 12.3 12 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.45213939250249e-05 6.73092623951481e-05 1.38292830410695 0.465116279069767 12.3 12 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00194767997517648 0.00567940287843469 1.38292830410695 0.465116279069767 12.3 12 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 8.04122903888081e-05 0.000322328702037391 1.38195441093504 0.464788732394366 12.3 12 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.61971697703338e-07 1.01186352994137e-06 1.38129492422021 0.464566929133858 12.3 12 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00357892138985133 0.00979385603415085 1.37229039407536 0.461538461538462 12.3 12 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0162775688803879 0.0368250882619905 1.37229039407536 0.461538461538462 12.3 12 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0824480468475072 0.150995586440158 1.37229039407536 0.461538461538462 12.3 12 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0824480468475072 0.150995586440158 1.37229039407536 0.461538461538462 12.3 12 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0824480468475072 0.150995586440158 1.37229039407536 0.461538461538462 12.3 12 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0824480468475072 0.150995586440158 1.37229039407536 0.461538461538462 12.3 12 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.18299623416195e-06 1.18565024473758e-05 1.36389718065593 0.458715596330275 12.3 12 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0223634769924299 0.0492305929382338 1.36276059967205 0.458333333333333 12.3 12 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.31320644156447e-21 1.37153865264427e-19 1.35998285690876 0.457399103139013 12.3 12 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00202517911830859 0.00588128548031251 1.35737419413975 0.456521739130435 12.3 12 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00202517911830859 0.00588128548031251 1.35737419413975 0.456521739130435 12.3 12 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.000202765829828055 0.000708472352333661 1.35547310983424 0.455882352941176 12.3 12 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 6.53245493798555e-05 0.000271011177164823 1.35491962959339 0.455696202531646 12.3 12 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00273498383013303 0.00770669701045406 1.35149811537724 0.454545454545455 12.3 12 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0307997797556186 0.065220366952746 1.35149811537724 0.454545454545455 12.3 12 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.117307350545492 0.19919852007904 1.35149811537724 0.454545454545455 12.3 12 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.117307350545492 0.19919852007904 1.35149811537724 0.454545454545455 12.3 12 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.117307350545492 0.19919852007904 1.35149811537724 0.454545454545455 12.3 12 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.117307350545492 0.19919852007904 1.35149811537724 0.454545454545455 12.3 12 3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.117307350545492 0.19919852007904 1.35149811537724 0.454545454545455 12.3 12 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.117307350545492 0.19919852007904 1.35149811537724 0.454545454545455 12.3 12 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.117307350545492 0.19919852007904 1.35149811537724 0.454545454545455 12.3 12 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.117307350545492 0.19919852007904 1.35149811537724 0.454545454545455 12.3 12 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.31153451169739e-12 5.26454787090843e-11 1.34506241006592 0.452380952380952 12.3 12 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.31153451169739e-12 5.26454787090843e-11 1.34506241006592 0.452380952380952 12.3 12 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.31153451169739e-12 5.26454787090843e-11 1.34506241006592 0.452380952380952 12.3 12 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0122138851752657 0.0289672643406717 1.34277877269739 0.451612903225806 12.3 12 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 6.75233379698204e-05 0.000278509304147984 1.34160910477692 0.451219512195122 12.3 12 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0425384101873917 0.0856183277180459 1.33798313422347 0.45 12.3 12 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0425384101873917 0.0856183277180459 1.33798313422347 0.45 12.3 12 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0425384101873917 0.0856183277180459 1.33798313422347 0.45 12.3 12 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0425384101873917 0.0856183277180459 1.33798313422347 0.45 12.3 12 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0425384101873917 0.0856183277180459 1.33798313422347 0.45 12.3 12 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.90266344137995e-05 0.00016727379750252 1.33631274329435 0.449438202247191 12.3 12 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00208224946598954 0.006034706700821 1.33494915886242 0.448979591836735 12.3 12 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.56673262442774e-09 2.24077332795133e-08 1.33178876786133 0.447916666666667 12.3 12 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 6.93812421293352e-05 0.000280481555539898 1.32923814641809 0.447058823529412 12.3 12 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 6.93812421293352e-05 0.000280481555539898 1.32923814641809 0.447058823529412 12.3 12 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 6.93812421293352e-05 0.000280481555539898 1.32923814641809 0.447058823529412 12.3 12 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 6.93812421293352e-05 0.000280481555539898 1.32923814641809 0.447058823529412 12.3 12 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 6.93812421293352e-05 0.000280481555539898 1.32923814641809 0.447058823529412 12.3 12 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 6.93812421293352e-05 0.000280481555539898 1.32923814641809 0.447058823529412 12.3 12 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 6.93812421293352e-05 0.000280481555539898 1.32923814641809 0.447058823529412 12.3 12 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.99008170589666e-09 1.76992891718185e-08 1.32817276719307 0.446700507614213 12.3 12 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 4.78763362394191e-07 2.74709784147957e-06 1.32621829451407 0.446043165467626 12.3 12 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.000286577841123521 0.00098502480173616 1.32146482392442 0.444444444444444 12.3 12 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00914318555561953 0.0224323328373217 1.32146482392442 0.444444444444444 12.3 12 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0589451669960366 0.113965995428478 1.32146482392442 0.444444444444444 12.3 12 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000123266000848995 0.000450919072514448 1.32146482392442 0.444444444444444 12.3 12 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.00377226177140099 0.0102441383601214 1.32146482392442 0.444444444444444 12.3 12 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0227163034243701 0.0495786806332496 1.32146482392442 0.444444444444444 12.3 12 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.07958241002532e-10 2.94110454326579e-09 1.31998336111733 0.443946188340807 12.3 12 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.359184448777e-26 1.38151390757833e-24 1.31786830224188 0.443234836702955 12.3 12 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 7.09086903614567e-05 0.000285844380692218 1.31771066249281 0.443181818181818 12.3 12 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.31546210280628e-31 2.0798917469926e-29 1.31342774593 0.441741357234315 12.3 12 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0123803903214719 0.0293133035398577 1.31174817080733 0.441176470588235 12.3 12 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 8.75679999983168e-07 4.92526735168399e-06 1.30740668749969 0.439716312056738 12.3 12 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00683935198291697 0.0172866747276925 1.30534939924241 0.439024390243902 12.3 12 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.27044121888049e-07 1.38662568861242e-06 1.3008169360506 0.4375 12.3 12 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00381508820487128 0.0103407057438702 1.3008169360506 0.4375 12.3 12 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0819995485031302 0.150951303389333 1.3008169360506 0.4375 12.3 12 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0819995485031302 0.150951303389333 1.3008169360506 0.4375 12.3 12 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0819995485031302 0.150951303389333 1.3008169360506 0.4375 12.3 12 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.005116171504549 0.0132610419872008 1.29273732775215 0.434782608695652 12.3 12 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0424937843095424 0.0856183277180459 1.29273732775215 0.434782608695652 12.3 12 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 3.03318856571258e-07 1.8135408945416e-06 1.29273732775215 0.434782608695652 12.3 12 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000223880733888921 0.000778929790523067 1.28962229804672 0.433734939759036 12.3 12 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.94901482811682e-07 3.93962075713555e-06 1.28523111101036 0.432258064516129 12.3 12 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 4.03321713964568e-07 2.35215901217861e-06 1.28475746770429 0.432098765432099 12.3 12 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00919737360563316 0.0225264417225749 1.2742696516414 0.428571428571429 12.3 12 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0582667739200876 0.113092696591699 1.2742696516414 0.428571428571429 12.3 12 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0308487388558151 0.0652269768080607 1.2742696516414 0.428571428571429 12.3 12 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.114606400803988 0.199097711875342 1.2742696516414 0.428571428571429 12.3 12 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.114606400803988 0.199097711875342 1.2742696516414 0.428571428571429 12.3 12 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.114606400803988 0.199097711875342 1.2742696516414 0.428571428571429 12.3 12 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.114606400803988 0.199097711875342 1.2742696516414 0.428571428571429 12.3 12 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.114606400803988 0.199097711875342 1.2742696516414 0.428571428571429 12.3 12 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.114606400803988 0.199097711875342 1.2742696516414 0.428571428571429 12.3 12 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.114606400803988 0.199097711875342 1.2742696516414 0.428571428571429 12.3 12 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.00683011165395338 0.0172866747276925 1.2652322782255 0.425531914893617 12.3 12 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0225222178515743 0.0492305929382338 1.26139824101876 0.424242424242424 12.3 12 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0225222178515743 0.0492305929382338 1.26139824101876 0.424242424242424 12.3 12 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0225222178515743 0.0492305929382338 1.26139824101876 0.424242424242424 12.3 12 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0225222178515743 0.0492305929382338 1.26139824101876 0.424242424242424 12.3 12 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0225222178515743 0.0492305929382338 1.26139824101876 0.424242424242424 12.3 12 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0418739361340419 0.0850022983148953 1.25793286123574 0.423076923076923 12.3 12 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0418739361340419 0.0850022983148953 1.25793286123574 0.423076923076923 12.3 12 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0418739361340419 0.0850022983148953 1.25793286123574 0.423076923076923 12.3 12 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0418739361340419 0.0850022983148953 1.25793286123574 0.423076923076923 12.3 12 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00911682308720342 0.0224062854112098 1.2553915827282 0.422222222222222 12.3 12 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0800475152748469 0.14817417258609 1.25191404371787 0.421052631578947 12.3 12 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0800475152748469 0.14817417258609 1.25191404371787 0.421052631578947 12.3 12 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0800475152748469 0.14817417258609 1.25191404371787 0.421052631578947 12.3 12 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000168452083796579 0.000599268288106331 1.24878425860857 0.42 12.3 12 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0303429668864693 0.0643487956474602 1.24686600321901 0.419354838709677 12.3 12 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 9.60110922036607e-05 0.000365304235844409 1.24337826614706 0.418181818181818 12.3 12 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.53329928734808e-12 2.69368504431644e-11 1.24019827058147 0.417112299465241 12.3 12 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00898369983186917 0.0221556410064988 1.23887327242914 0.416666666666667 12.3 12 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0568725752503369 0.110559664728455 1.23887327242914 0.416666666666667 12.3 12 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.161094528183729 0.2653211963026 1.23887327242914 0.416666666666667 12.3 12 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.161094528183729 0.2653211963026 1.23887327242914 0.416666666666667 12.3 12 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.161094528183729 0.2653211963026 1.23887327242914 0.416666666666667 12.3 12 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.161094528183729 0.2653211963026 1.23887327242914 0.416666666666667 12.3 12 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.161094528183729 0.2653211963026 1.23887327242914 0.416666666666667 12.3 12 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.161094528183729 0.2653211963026 1.23887327242914 0.416666666666667 12.3 12 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.161094528183729 0.2653211963026 1.23887327242914 0.416666666666667 12.3 12 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.13873595561768e-06 6.32977056579673e-06 1.22810046136454 0.41304347826087 12.3 12 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 7.74770453842072e-06 3.86841528356936e-05 1.22768344932333 0.412903225806452 12.3 12 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0296214971226459 0.0629125229933211 1.2242982927535 0.411764705882353 12.3 12 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.110199145480744 0.193119931058003 1.2242982927535 0.411764705882353 12.3 12 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.110199145480744 0.193119931058003 1.2242982927535 0.411764705882353 12.3 12 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.110199145480744 0.193119931058003 1.2242982927535 0.411764705882353 12.3 12 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0216028985903871 0.047660348362978 1.21981368362254 0.41025641025641 12.3 12 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 9.75996333119429e-06 4.69203642577347e-05 1.21549830502482 0.408805031446541 12.3 12 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 9.75996333119429e-06 4.69203642577347e-05 1.21549830502482 0.408805031446541 12.3 12 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.2674515982271e-05 6.03205225510755e-05 1.21204416971411 0.407643312101911 12.3 12 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0550448086219412 0.107446862371773 1.21134275526405 0.407407407407407 12.3 12 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0550448086219412 0.107446862371773 1.21134275526405 0.407407407407407 12.3 12 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 1.21672801774089e-05 5.81008043370903e-05 1.20391120461826 0.404907975460123 12.3 12 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000449161164412742 0.00146932491255019 1.19487590387558 0.401869158878505 12.3 12 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0382245838762327 0.0795823623015934 1.18931834153197 0.4 12.3 12 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.0529632671560341 0.103810921712172 1.18931834153197 0.4 12.3 12 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0740911561942823 0.138835780307842 1.18931834153197 0.4 12.3 12 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0277861552349706 0.0600125387105749 1.18931834153197 0.4 12.3 12 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.10505358533315 0.18541283700104 1.18931834153197 0.4 12.3 12 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00012457940519451 0.000454555111773813 1.17256737897519 0.394366197183099 12.3 12 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0507452880892153 0.1007120571143 1.17129836666028 0.393939393939394 12.3 12 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.52841698120967e-36 2.71867170532671e-34 1.17089120131457 0.39380245319561 12.3 12 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0707010890588464 0.134143532974318 1.16808051400462 0.392857142857143 12.3 12 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0707010890588464 0.134143532974318 1.16808051400462 0.392857142857143 12.3 12 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0996464858787625 0.181094443685158 1.16346359497693 0.391304347826087 12.3 12 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0484687303311905 0.097279271172474 1.15628172093386 0.388888888888889 12.3 12 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.142815313607376 0.241648265473598 1.15628172093386 0.388888888888889 12.3 12 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0672497725894434 0.1279363989235 1.15095323374062 0.387096774193548 12.3 12 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00911383756528616 0.0224062854112098 1.14684268647726 0.385714285714286 12.3 12 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0942269187319326 0.171683617612727 1.14357532839613 0.384615384615385 12.3 12 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.210248579018869 0.330955451265321 1.14357532839613 0.384615384615385 12.3 12 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.210248579018869 0.330955451265321 1.14357532839613 0.384615384615385 12.3 12 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.210248579018869 0.330955451265321 1.14357532839613 0.384615384615385 12.3 12 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.210248579018869 0.330955451265321 1.14357532839613 0.384615384615385 12.3 12 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.210248579018869 0.330955451265321 1.14357532839613 0.384615384615385 12.3 12 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00623571492478142 0.0159881483566918 1.1379280428238 0.382716049382716 12.3 12 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.000511888478094956 0.00165926493013468 1.13684841469968 0.382352941176471 12.3 12 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0638219205923299 0.121740741290731 1.13684841469968 0.382352941176471 12.3 12 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.000625437482109171 0.00200449895730034 1.12855025108874 0.37956204379562 12.3 12 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.000625437482109171 0.00200449895730034 1.12855025108874 0.37956204379562 12.3 12 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.000599731517575994 0.00193080984052181 1.1256048589499 0.378571428571429 12.3 12 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0417289411705575 0.0850022983148953 1.12324510033575 0.377777777777778 12.3 12 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0838233708002952 0.15331703939437 1.11498594518623 0.375 12.3 12 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 6.80695094841435e-11 6.91877942828116e-10 1.10912787542168 0.373029772329247 12.3 12 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00213525357462165 0.00617574357050122 1.10299684900143 0.370967741935484 12.3 12 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.109750744013074 0.193047353189869 1.09020847973764 0.366666666666667 12.3 12 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0430278443005657 0.0864811051408262 1.0811984923018 0.363636363636364 12.3 12 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00405141908738738 0.01083678451382 1.08119849230179 0.363636363636364 12.3 12 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0361480440156916 0.0755340185526126 1.06852819747013 0.359375 12.3 12 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0548039178694317 0.107270942404679 1.06589851363715 0.358490566037736 12.3 12 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0843855465680929 0.154147153743769 1.06189137636783 0.357142857142857 12.3 12 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.143149735317626 0.241926452918031 1.06189137636783 0.357142857142857 12.3 12 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.13312627829607 0.225522254780128 1.05504046426224 0.354838709677419 12.3 12 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0741498194195078 0.138835780307842 1.05304228156477 0.354166666666667 12.3 12 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0741498194195078 0.138835780307842 1.05304228156477 0.354166666666667 12.3 12 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.239818978189336 0.367343816968165 1.04939853664586 0.352941176470588 12.3 12 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.239818978189336 0.367343816968165 1.04939853664586 0.352941176470588 12.3 12 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0652505761324236 0.124299290276357 1.0461596522735 0.351851851851852 12.3 12 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.115515001491357 0.199097711875342 1.04467151621052 0.351351351351351 12.3 12 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.219478627335511 0.344570921846202 1.04065354884048 0.35 12.3 12 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.201644962611301 0.319177732809656 1.03418986220172 0.347826086956522 12.3 12 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.201644962611301 0.319177732809656 1.03418986220172 0.347826086956522 12.3 12 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.171687138555591 0.273908813568438 1.02527443235515 0.344827586206897 12.3 12 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0292595612975416 0.0622367051216766 1.02306954110277 0.344086021505376 12.3 12 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.158951610793857 0.26393015421197 1.02207044975404 0.34375 12.3 12 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.158951610793857 0.26393015421197 1.02207044975404 0.34375 12.3 12 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0963342889992194 0.175298840467889 1.00979859186677 0.339622641509434 12.3 12 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.288320810480316 0.41993911291043 0.991098617943312 0.333333333333333 12.3 12 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.288320810480316 0.41993911291043 0.991098617943312 0.333333333333333 12.3 12 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.288320810480316 0.41993911291043 0.991098617943312 0.333333333333333 12.3 12 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.288320810480316 0.41993911291043 0.991098617943312 0.333333333333333 12.3 12 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.128768966810112 0.218400762539677 0.991098617943312 0.333333333333333 12.3 12 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.187064850016044 0.297422660975229 0.991098617943312 0.333333333333333 12.3 12 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.239812027789042 0.367343816968165 0.991098617943312 0.333333333333333 12.3 12 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.319052642757019 0.461394218133372 0.991098617943312 0.333333333333333 12.3 12 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.220108902289668 0.344570921846202 0.991098617943312 0.333333333333333 12.3 12 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.220108902289668 0.344570921846202 0.991098617943312 0.333333333333333 12.3 12 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.220108902289668 0.344570921846202 0.991098617943312 0.333333333333333 12.3 12 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0620404391211882 0.11978771352707 0.979836133648502 0.329545454545455 12.3 12 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0802890103950842 0.148378262067798 0.978057846654584 0.328947368421053 12.3 12 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.148589043065995 0.25082112489076 0.970872115536306 0.326530612244898 12.3 12 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.200660262176102 0.318327260954954 0.964312168809709 0.324324324324324 12.3 12 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.0583345321843337 0.113092696591699 0.962781514573503 0.323809523809524 12.3 12 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.256563244539582 0.383900627739038 0.955702238731051 0.321428571428571 12.3 12 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.169967312024063 0.273908813568438 0.95145467322558 0.32 12.3 12 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.280136793788388 0.410117960453577 0.95145467322558 0.32 12.3 12 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.212786698492807 0.334580631994768 0.942752343897297 0.317073170731707 12.3 12 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.338578171024454 0.485193088990733 0.938935532788401 0.315789473684211 12.3 12 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00111870182888558 0.00340880664347791 0.931032035037657 0.313131313131313 12.3 12 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.375862570401462 0.525911934789853 0.929154954321855 0.3125 12.3 12 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.294757492232378 0.427563620231064 0.922746989119635 0.310344827586207 12.3 12 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.241443651702189 0.369434748787328 0.92030585951879 0.30952380952381 12.3 12 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0921638890435254 0.16814001808838 0.913059356687933 0.307086614173228 12.3 12 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.307033437318438 0.444464477420282 0.900998743584829 0.303030303030303 12.3 12 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.307033437318438 0.444464477420282 0.900998743584829 0.303030303030303 12.3 12 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.38962083260543 0.544092683805227 0.891988756148981 0.3 12.3 12 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.38962083260543 0.544092683805227 0.891988756148981 0.3 12.3 12 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0524085154647457 0.102865265525977 0.886158764278726 0.298039215686275 12.3 12 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.280768851015145 0.410620837610022 0.885662594757854 0.297872340425532 12.3 12 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.364973244522417 0.519755167195651 0.880976549282944 0.296296296296296 12.3 12 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.364973244522417 0.519755167195651 0.880976549282944 0.296296296296296 12.3 12 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.40005227715932 0.557565514591295 0.867211290700398 0.291666666666667 12.3 12 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.40005227715932 0.557565514591295 0.867211290700398 0.291666666666667 12.3 12 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.374511158942372 0.52453679052657 0.863214925305466 0.290322580645161 12.3 12 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.440551083102225 0.593659272021275 0.849513101094268 0.285714285714286 12.3 12 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.408337244515551 0.565787632858451 0.849513101094268 0.285714285714286 12.3 12 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.19955730970061 0.316930861276749 0.835737212968415 0.281081081081081 12.3 12 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.446686076248015 0.600221233711921 0.832522839072382 0.28 12.3 12 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.446686076248015 0.600221233711921 0.832522839072382 0.28 12.3 12 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.446686076248015 0.600221233711921 0.832522839072382 0.28 12.3 12 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.227176741099071 0.350429114499474 0.829756982464168 0.27906976744186 12.3 12 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.275839814721825 0.404243106435795 0.828623434673917 0.278688524590164 12.3 12 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.488019165878129 0.646001184227513 0.82591551495276 0.277777777777778 12.3 12 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.324933847986146 0.467121798026775 0.822400980846578 0.276595744680851 12.3 12 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.494287858520608 0.653691099140172 0.79287889435465 0.266666666666667 12.3 12 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.467113486201173 0.626888474592583 0.788833593873249 0.26530612244898 12.3 12 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.472886254598297 0.630072228739117 0.779880879693098 0.262295081967213 12.3 12 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.152314214861418 0.256804653729619 0.777408086659925 0.261463414634146 12.3 12 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.53409697529035 0.704374416902844 0.762383552264086 0.256410256410256 12.3 12 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.53409697529035 0.704374416902844 0.762383552264086 0.256410256410256 12.3 12 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.505062783996261 0.667320651463955 0.752279673860586 0.253012048192771 12.3 12 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.585341281977273 0.742371340689536 0.743323963457484 0.25 12.3 12 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.591980988804111 0.75012372846683 0.743323963457484 0.25 12.3 12 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.580585866335136 0.737480220826131 0.734578975652102 0.247058823529412 12.3 12 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.580585866335136 0.737480220826131 0.734578975652102 0.247058823529412 12.3 12 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.620474768939431 0.779978441873508 0.725194110690229 0.24390243902439 12.3 12 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.60950637202691 0.768907417902743 0.723234126607282 0.243243243243243 12.3 12 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.618289320563665 0.777918393600438 0.719345771087888 0.241935483870968 12.3 12 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.632932598033748 0.793535759473149 0.715096471174289 0.240506329113924 12.3 12 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.629127136418091 0.789460242612825 0.713591004919185 0.24 12.3 12 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.629127136418091 0.789460242612825 0.713591004919185 0.24 12.3 12 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.659810487724779 0.822163155895237 0.693769032560319 0.233333333333333 12.3 12 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.69167178627373 0.845574700917112 0.689459908134478 0.231884057971014 12.3 12 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.670083940807609 0.833504762036039 0.686145197037678 0.230769230769231 12.3 12 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.670083940807609 0.833504762036039 0.686145197037678 0.230769230769231 12.3 12 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.701616219227529 0.85515596405214 0.682395769731461 0.229508196721311 12.3 12 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.693214926651899 0.846733768777384 0.681380299836027 0.229166666666667 12.3 12 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.83315807875533 0.981443663964267 0.676279056949554 0.227450980392157 12.3 12 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.755273447605335 0.912920539124522 0.646368663876073 0.217391304347826 12.3 12 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.760329546410179 0.912920539124522 0.63069912050938 0.212121212121212 12.3 12 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.774621603178513 0.923188058059484 0.61516465941309 0.206896551724138 12.3 12 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.876716332692175 1 0.613050691511327 0.206185567010309 12.3 12 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.90294400089743 1 0.600377047407968 0.201923076923077 12.3 12 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.814218165640703 0.966332318354229 0.594659170765987 0.2 12.3 12 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.935219283362538 1 0.570632537603725 0.191919191919192 12.3 12 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.93918520181605 1 0.563361319673041 0.189473684210526 12.3 12 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.891027633915819 1 0.560999217703762 0.188679245283019 12.3 12 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.881423370576115 1 0.553171321642779 0.186046511627907 12.3 12 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.876767001202105 1 0.547712394126567 0.184210526315789 12.3 12 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.89046530987057 1 0.52469926832293 0.176470588235294 12.3 12 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.935531431592968 1 0.521630851549112 0.175438596491228 12.3 12 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.920721483104139 1 0.50763587748316 0.170731707317073 12.3 12 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.96422758163263 1 0.502528876703651 0.169014084507042 12.3 12 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.94202981862032 1 0.495549308971656 0.166666666666667 12.3 12 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.976653276108782 1 0.489276532908724 0.164556962025316 12.3 12 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.972719252815915 1 0.471951722830149 0.158730158730159 12.3 12 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999964233858 1 0.421472350414037 0.141752577319588 12.3 12 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999998687219549 1 0.414137636783455 0.139285714285714 12.3 12 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999986062444488 1 0.411054726335936 0.138248847926267 12.3 12 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.381959920769085 0.128463476070529 12.3 12 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.99207255578075 1 0.364077043326115 0.122448979591837 12.3 12 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.309158248815952 0.103978300180832 12.3 12 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999999925962957 1 0.303723770014886 0.102150537634409 12.3 12 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999951048584 1 0.287193349517664 0.0965909090909091 12.3 12 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999986498945 1 0.165183102990552 0.0555555555555556 12.3 12 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 2.84458433268925e-05 0.000108231109770503 2.1988684582744 1 12.2 12 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 2.84458433268925e-05 0.000108231109770503 2.1988684582744 1 12.2 12 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 9.10417308931664e-05 0.000318310523491341 2.1988684582744 1 12.2 12 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 9.10417308931664e-05 0.000318310523491341 2.1988684582744 1 12.2 12 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 9.10417308931664e-05 0.000318310523491341 2.1988684582744 1 12.2 12 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 9.10417308931664e-05 0.000318310523491341 2.1988684582744 1 12.2 12 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.000291362746433622 0.000944440064180056 2.1988684582744 1 12.2 12 2 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.000932393776161487 0.00267108818853419 2.1988684582744 1 12.2 12 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.000932393776161487 0.00267108818853419 2.1988684582744 1 12.2 12 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00298357212203976 0.00740946444967291 2.1988684582744 1 12.2 12 2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.00298357212203976 0.00740946444967291 2.1988684582744 1 12.2 12 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 9.90792670489962e-08 5.59462421939014e-07 2.06952325484649 0.941176470588235 12.2 12 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 2.69286298805293e-06 1.24413767272705e-05 2.04180642554051 0.928571428571429 12.2 12 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 8.02418872493666e-06 3.40848374793578e-05 2.02972473071483 0.923076923076923 12.2 12 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 2.37768429469315e-05 9.29517788831964e-05 2.01562942008487 0.916666666666667 12.2 12 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 2.37768429469315e-05 9.29517788831964e-05 2.01562942008487 0.916666666666667 12.2 12 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 6.99955318704738e-05 0.000251524348110314 1.998971325704 0.909090909090909 12.2 12 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 6.99955318704738e-05 0.000251524348110314 1.998971325704 0.909090909090909 12.2 12 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 6.99955318704738e-05 0.000251524348110314 1.998971325704 0.909090909090909 12.2 12 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 7.5874214588371e-08 4.37121487284421e-07 1.97898161244696 0.9 12.2 12 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 7.5874214588371e-08 4.37121487284421e-07 1.97898161244696 0.9 12.2 12 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000204472898755412 0.000670426117347815 1.97898161244696 0.9 12.2 12 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000204472898755412 0.000670426117347815 1.97898161244696 0.9 12.2 12 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 3.14493867042574e-11 2.96374021722902e-10 1.97898161244696 0.9 12.2 12 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000591808831423359 0.00178420332015983 1.95454974068835 0.888888888888889 12.2 12 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000591808831423359 0.00178420332015983 1.95454974068835 0.888888888888889 12.2 12 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 2.13907850441465e-09 1.569025109166e-08 1.94515286693505 0.884615384615385 12.2 12 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.79896504362704e-06 8.59035992309153e-06 1.94017805141859 0.882352941176471 12.2 12 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.10112253465468e-06 2.24733664607232e-05 1.9240099009901 0.875 12.2 12 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.10112253465468e-06 2.24733664607232e-05 1.9240099009901 0.875 12.2 12 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 5.10112253465468e-06 2.24733664607232e-05 1.9240099009901 0.875 12.2 12 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 5.10112253465468e-06 2.24733664607232e-05 1.9240099009901 0.875 12.2 12 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00169360985521681 0.00453861925418742 1.9240099009901 0.875 12.2 12 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00169360985521681 0.00453861925418742 1.9240099009901 0.875 12.2 12 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00169360985521681 0.00453861925418742 1.9240099009901 0.875 12.2 12 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00169360985521681 0.00453861925418742 1.9240099009901 0.875 12.2 12 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 4.00121431462389e-05 0.00014788903817428 1.88474439280663 0.857142857142857 12.2 12 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00477857995452866 0.011239535992222 1.88474439280663 0.857142857142857 12.2 12 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00477857995452866 0.011239535992222 1.88474439280663 0.857142857142857 12.2 12 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00477857995452866 0.011239535992222 1.88474439280663 0.857142857142857 12.2 12 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00477857995452866 0.011239535992222 1.88474439280663 0.857142857142857 12.2 12 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00477857995452866 0.011239535992222 1.88474439280663 0.857142857142857 12.2 12 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 1.03170186878492e-06 5.07997148540121e-06 1.86903818953324 0.85 12.2 12 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 2.77317678785606e-08 1.65808007105848e-07 1.86058100315526 0.846153846153846 12.2 12 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000110416441167903 0.000381365523742538 1.86058100315526 0.846153846153846 12.2 12 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.000110416441167903 0.000381365523742538 1.86058100315526 0.846153846153846 12.2 12 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 7.63586874189478e-10 6.00322719321341e-09 1.85529526166902 0.84375 12.2 12 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 7.54353340767435e-08 4.37121487284421e-07 1.84704950495049 0.84 12.2 12 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 7.54353340767435e-08 4.37121487284421e-07 1.84704950495049 0.84 12.2 12 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.3278711309364e-15 2.42251361451602e-14 1.83905361964768 0.836363636363636 12.2 12 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.58234546993409e-09 3.61076254714373e-08 1.83239038189533 0.833333333333333 12.2 12 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.03764732287782e-07 1.10249891272059e-06 1.83239038189533 0.833333333333333 12.2 12 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 2.03764732287782e-07 1.10249891272059e-06 1.83239038189533 0.833333333333333 12.2 12 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 7.64381074694351e-06 3.26640921708727e-05 1.83239038189533 0.833333333333333 12.2 12 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000301088976488185 0.000967089882547101 1.83239038189533 0.833333333333333 12.2 12 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000301088976488185 0.000967089882547101 1.83239038189533 0.833333333333333 12.2 12 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.000301088976488185 0.000967089882547101 1.83239038189533 0.833333333333333 12.2 12 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0132394638514311 0.02778725230175 1.83239038189533 0.833333333333333 12.2 12 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0132394638514311 0.02778725230175 1.83239038189533 0.833333333333333 12.2 12 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0132394638514311 0.02778725230175 1.83239038189533 0.833333333333333 12.2 12 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0132394638514311 0.02778725230175 1.83239038189533 0.833333333333333 12.2 12 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0132394638514311 0.02778725230175 1.83239038189533 0.833333333333333 12.2 12 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0132394638514311 0.02778725230175 1.83239038189533 0.833333333333333 12.2 12 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.1101051268189e-09 8.49290105087795e-09 1.81083284799068 0.823529411764706 12.2 12 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 2.05111908261171e-05 8.10761792932349e-05 1.81083284799068 0.823529411764706 12.2 12 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.36613082033473e-12 2.53158207318521e-11 1.80795851013673 0.822222222222222 12.2 12 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.95327790529296e-16 7.70618419072861e-15 1.80235119530688 0.819672131147541 12.2 12 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.95327790529296e-16 7.70618419072861e-15 1.80235119530688 0.819672131147541 12.2 12 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 6.25371850685494e-12 6.35645816803898e-11 1.7990741931336 0.818181818181818 12.2 12 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 1.45212244945308e-06 6.95747557431559e-06 1.7990741931336 0.818181818181818 12.2 12 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000809621049737636 0.00236568943280628 1.7990741931336 0.818181818181818 12.2 12 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 1.05183288090259e-07 5.84685934234335e-07 1.79167059563099 0.814814814814815 12.2 12 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 1.05183288090259e-07 5.84685934234335e-07 1.79167059563099 0.814814814814815 12.2 12 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 5.4433127408796e-05 0.000198611128981325 1.78658062234795 0.8125 12.2 12 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 5.4433127408796e-05 0.000198611128981325 1.78658062234795 0.8125 12.2 12 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 5.4433127408796e-05 0.000198611128981325 1.78658062234795 0.8125 12.2 12 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.24142706115984e-12 1.36941915351198e-11 1.78658062234795 0.8125 12.2 12 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 9.4083898737574e-14 1.28266830349403e-12 1.78398761709055 0.811320754716981 12.2 12 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 5.45404174009355e-16 1.03481351948708e-14 1.78003637098404 0.80952380952381 12.2 12 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 3.82534951323096e-06 1.74470267863066e-05 1.78003637098404 0.80952380952381 12.2 12 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 3.82534951323096e-06 1.74470267863066e-05 1.78003637098404 0.80952380952381 12.2 12 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.18906789850977e-18 9.86531221647695e-17 1.77716765805739 0.808219178082192 12.2 12 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 2.7579031210911e-07 1.47537448921528e-06 1.77600913937548 0.807692307692308 12.2 12 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.12051180184237e-10 9.84252033346721e-10 1.76982095422086 0.804878048780488 12.2 12 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.12051180184237e-10 9.84252033346721e-10 1.76982095422086 0.804878048780488 12.2 12 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.12051180184237e-10 9.84252033346721e-10 1.76982095422086 0.804878048780488 12.2 12 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.12051180184237e-10 9.84252033346721e-10 1.76982095422086 0.804878048780488 12.2 12 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 4.83629520245432e-14 7.02249803376786e-13 1.76694786825621 0.803571428571429 12.2 12 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 9.97643977956961e-06 4.17543347244928e-05 1.75909476661952 0.8 12.2 12 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 9.97643977956961e-06 4.17543347244928e-05 1.75909476661952 0.8 12.2 12 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00214115256209515 0.00552350620015163 1.75909476661952 0.8 12.2 12 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00214115256209515 0.00552350620015163 1.75909476661952 0.8 12.2 12 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00214115256209515 0.00552350620015163 1.75909476661952 0.8 12.2 12 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00214115256209515 0.00552350620015163 1.75909476661952 0.8 12.2 12 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00214115256209515 0.00552350620015163 1.75909476661952 0.8 12.2 12 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 9.50850324655555e-15 1.67044445924056e-13 1.75909476661952 0.8 12.2 12 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000142657221936971 0.000483336254324547 1.75909476661952 0.8 12.2 12 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000142657221936971 0.000483336254324547 1.75909476661952 0.8 12.2 12 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 5.54423251975249e-17 1.46100793992737e-15 1.75909476661952 0.8 12.2 12 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.24961784917322e-13 1.55982999945044e-12 1.75909476661952 0.8 12.2 12 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 7.17082325131939e-07 3.5803794689921e-06 1.75909476661952 0.8 12.2 12 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 7.17082325131939e-07 3.5803794689921e-06 1.75909476661952 0.8 12.2 12 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 7.17082325131939e-07 3.5803794689921e-06 1.75909476661952 0.8 12.2 12 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.42643832898438e-16 3.12280268022272e-15 1.7527212348564 0.797101449275362 12.2 12 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.42643832898438e-16 3.12280268022272e-15 1.7527212348564 0.797101449275362 12.2 12 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 2.44609565565085e-14 3.86754901999017e-13 1.75164097523554 0.796610169491525 12.2 12 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 3.214644072423e-13 3.94348147849821e-12 1.75095080936665 0.796296296296296 12.2 12 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 3.214644072423e-13 3.94348147849821e-12 1.75095080936665 0.796296296296296 12.2 12 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 9.9954868814997e-09 6.34981153230985e-08 1.74616024627673 0.794117647058823 12.2 12 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 6.26629997537379e-14 8.82865828213554e-13 1.74393015656245 0.793103448275862 12.2 12 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 6.26629997537379e-14 8.82865828213554e-13 1.74393015656245 0.793103448275862 12.2 12 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 8.23195439357053e-13 9.68105049756269e-12 1.74249953297217 0.792452830188679 12.2 12 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 1.8475835871354e-06 8.79301486452732e-06 1.74077086280057 0.791666666666667 12.2 12 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 1.90847998158652e-09 1.40713316777079e-08 1.73594878284821 0.789473684210526 12.2 12 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 1.90847998158652e-09 1.40713316777079e-08 1.73594878284821 0.789473684210526 12.2 12 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.82258089828245e-16 3.7587429250086e-15 1.73431878399108 0.788732394366197 12.2 12 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 2.0980011789066e-12 2.27897379968251e-11 1.73372320748558 0.788461538461538 12.2 12 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.10246132130935e-14 4.74709941959485e-13 1.73025714749461 0.786885245901639 12.2 12 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 5.34009294407022e-19 1.76719819986324e-17 1.72768236007274 0.785714285714286 12.2 12 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 5.34009294407022e-19 1.76719819986324e-17 1.72768236007274 0.785714285714286 12.2 12 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 3.44899821705914e-07 1.8043839937041e-06 1.72768236007274 0.785714285714286 12.2 12 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000368565533914004 0.00115521752149698 1.72768236007274 0.785714285714286 12.2 12 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000368565533914004 0.00115521752149698 1.72768236007274 0.785714285714286 12.2 12 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000368565533914004 0.00115521752149698 1.72768236007274 0.785714285714286 12.2 12 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.000368565533914004 0.00115521752149698 1.72768236007274 0.785714285714286 12.2 12 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000368565533914004 0.00115521752149698 1.72768236007274 0.785714285714286 12.2 12 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.000368565533914004 0.00115521752149698 1.72768236007274 0.785714285714286 12.2 12 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 6.92852842023658e-18 2.01210121265238e-16 1.72569423307611 0.784810126582278 12.2 12 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 8.99475639404526e-17 2.09828497520105e-15 1.72343744026912 0.783783783783784 12.2 12 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 8.99475639404526e-17 2.09828497520105e-15 1.72343744026912 0.783783783783784 12.2 12 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 7.85198262155686e-14 1.08479332723062e-12 1.72244695898161 0.783333333333333 12.2 12 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 6.9950532888525e-11 6.34010243951408e-10 1.72085357604083 0.782608695652174 12.2 12 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 4.71334609011242e-06 2.10914826611005e-05 1.72085357604083 0.782608695652174 12.2 12 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.02559880390682e-12 1.15827547457095e-11 1.71911534010544 0.781818181818182 12.2 12 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.02559880390682e-12 1.15827547457095e-11 1.71911534010544 0.781818181818182 12.2 12 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.02559880390682e-12 1.15827547457095e-11 1.71911534010544 0.781818181818182 12.2 12 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.02559880390682e-12 1.15827547457095e-11 1.71911534010544 0.781818181818182 12.2 12 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.02559880390682e-12 1.15827547457095e-11 1.71911534010544 0.781818181818182 12.2 12 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.26784924152197e-16 4.61021352955109e-15 1.71692468659782 0.780821917808219 12.2 12 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 8.72914896175092e-07 4.32807629706326e-06 1.71023102310231 0.777777777777778 12.2 12 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.81885115759578e-14 5.70804075813844e-13 1.71023102310231 0.777777777777778 12.2 12 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.2230025407396e-08 7.73481162432202e-08 1.71023102310231 0.777777777777778 12.2 12 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0055499134384939 0.0127174344975472 1.71023102310231 0.777777777777778 12.2 12 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0055499134384939 0.0127174344975472 1.71023102310231 0.777777777777778 12.2 12 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0055499134384939 0.0127174344975472 1.71023102310231 0.777777777777778 12.2 12 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0055499134384939 0.0127174344975472 1.71023102310231 0.777777777777778 12.2 12 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0055499134384939 0.0127174344975472 1.71023102310231 0.777777777777778 12.2 12 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0055499134384939 0.0127174344975472 1.71023102310231 0.777777777777778 12.2 12 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.10330077450309e-16 2.49205873352047e-15 1.70701630313407 0.776315789473684 12.2 12 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 7.33425184299776e-23 3.72737156163779e-21 1.7056643181007 0.775700934579439 12.2 12 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 9.55466199370114e-14 1.28266830349403e-12 1.70234977414792 0.774193548387097 12.2 12 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.38692968907061e-25 3.06624037901899e-23 1.69996553076676 0.773109243697479 12.2 12 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 3.06235206877782e-08 1.82331673383717e-07 1.69626995352596 0.771428571428571 12.2 12 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.84374405787157e-21 2.59863993573476e-19 1.69312871287129 0.77 12.2 12 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.18805570187469e-06 1.02759183622696e-05 1.69143727559569 0.769230769230769 12.2 12 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 2.18805570187469e-06 1.02759183622696e-05 1.69143727559569 0.769230769230769 12.2 12 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 2.18805570187469e-06 1.02759183622696e-05 1.69143727559569 0.769230769230769 12.2 12 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000936664094222461 0.00267108818853419 1.69143727559569 0.769230769230769 12.2 12 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000936664094222461 0.00267108818853419 1.69143727559569 0.769230769230769 12.2 12 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000936664094222461 0.00267108818853419 1.69143727559569 0.769230769230769 12.2 12 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000936664094222461 0.00267108818853419 1.69143727559569 0.769230769230769 12.2 12 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.000936664094222461 0.00267108818853419 1.69143727559569 0.769230769230769 12.2 12 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 4.94539028854427e-18 1.49729582565925e-16 1.68750370053617 0.767441860465116 12.2 12 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.084778484448e-10 1.80892669717653e-09 1.68423967016762 0.765957446808511 12.2 12 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.13296278914904e-13 1.42673101677795e-12 1.68350866336634 0.765625 12.2 12 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.000164679421302503 0.00055138545061991 1.68148764456278 0.764705882352941 12.2 12 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.59514721275301e-22 1.23096482791584e-20 1.67913591359136 0.763636363636364 12.2 12 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 2.96599286318531e-05 0.000112549542515005 1.67532834916145 0.761904761904762 12.2 12 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 7.06004932646493e-26 4.56656826889072e-24 1.67452290283973 0.761538461538461 12.2 12 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.36039149242423e-14 7.7048859532522e-13 1.67376554286559 0.761194029850746 12.2 12 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 9.78396121522633e-11 8.81175747421966e-10 1.67114002828854 0.76 12.2 12 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 5.42750425014635e-06 2.38210672401753e-05 1.67114002828854 0.76 12.2 12 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.86726389604418e-11 1.83249415453163e-10 1.66951123683797 0.759259259259259 12.2 12 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 3.51958413984112e-08 2.07816109169872e-07 1.66400856301846 0.756756756756757 12.2 12 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 3.51958413984112e-08 2.07816109169872e-07 1.66400856301846 0.756756756756757 12.2 12 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.80004787677123e-16 3.7587429250086e-15 1.66255907820747 0.75609756097561 12.2 12 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.03491675361387e-24 5.66417900150973e-23 1.66213678735703 0.755905511811024 12.2 12 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 6.69677508268486e-18 1.98531477972095e-16 1.6613672795851 0.755555555555556 12.2 12 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.39332312187045e-10 2.06405988025555e-09 1.66037006032965 0.755102040816326 12.2 12 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 8.44301363274575e-17 2.03634040667749e-15 1.65561860387719 0.752941176470588 12.2 12 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 8.44301363274575e-17 2.03634040667749e-15 1.65561860387719 0.752941176470588 12.2 12 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 8.44301363274575e-17 2.03634040667749e-15 1.65561860387719 0.752941176470588 12.2 12 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.28999875043861e-25 1.3577784257809e-23 1.65328455509353 0.75187969924812 12.2 12 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 7.29933430890899e-05 0.000261636088704723 1.6491513437058 0.75 12.2 12 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.86492033971049e-14 4.43128439500872e-13 1.6491513437058 0.75 12.2 12 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.86492033971049e-14 4.43128439500872e-13 1.6491513437058 0.75 12.2 12 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 8.58040065289248e-08 4.92335085849435e-07 1.6491513437058 0.75 12.2 12 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 2.45696011958263e-06 1.14256674842029e-05 1.6491513437058 0.75 12.2 12 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.45696011958263e-06 1.14256674842029e-05 1.6491513437058 0.75 12.2 12 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 1.33106335990435e-05 5.47428659290143e-05 1.6491513437058 0.75 12.2 12 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.000407329505521493 0.00125461014363005 1.6491513437058 0.75 12.2 12 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000407329505521493 0.00125461014363005 1.6491513437058 0.75 12.2 12 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.000407329505521493 0.00125461014363005 1.6491513437058 0.75 12.2 12 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00233521726948599 0.00588144101677622 1.6491513437058 0.75 12.2 12 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00233521726948599 0.00588144101677622 1.6491513437058 0.75 12.2 12 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00233521726948599 0.00588144101677622 1.6491513437058 0.75 12.2 12 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00233521726948599 0.00588144101677622 1.6491513437058 0.75 12.2 12 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00233521726948599 0.00588144101677622 1.6491513437058 0.75 12.2 12 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00233521726948599 0.00588144101677622 1.6491513437058 0.75 12.2 12 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0140334902524643 0.0286508703432663 1.6491513437058 0.75 12.2 12 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0140334902524643 0.0286508703432663 1.6491513437058 0.75 12.2 12 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0140334902524643 0.0286508703432663 1.6491513437058 0.75 12.2 12 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0140334902524643 0.0286508703432663 1.6491513437058 0.75 12.2 12 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0140334902524643 0.0286508703432663 1.6491513437058 0.75 12.2 12 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0140334902524643 0.0286508703432663 1.6491513437058 0.75 12.2 12 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0140334902524643 0.0286508703432663 1.6491513437058 0.75 12.2 12 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0140334902524643 0.0286508703432663 1.6491513437058 0.75 12.2 12 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.37173550948748e-31 2.41069973571478e-29 1.6426840835344 0.747058823529412 12.2 12 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.33053136789744e-14 2.20156527502099e-13 1.64182178217822 0.746666666666667 12.2 12 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.33053136789744e-14 2.20156527502099e-13 1.64182178217822 0.746666666666667 12.2 12 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.33053136789744e-14 2.20156527502099e-13 1.64182178217822 0.746666666666667 12.2 12 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.33053136789744e-14 2.20156527502099e-13 1.64182178217822 0.746666666666667 12.2 12 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.33053136789744e-14 2.20156527502099e-13 1.64182178217822 0.746666666666667 12.2 12 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.5978703145547e-13 4.37587133129174e-12 1.64094661065254 0.746268656716418 12.2 12 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 5.71541531473901e-31 5.42202399524908e-29 1.63939305173121 0.745562130177515 12.2 12 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 2.67619799131108e-10 2.29411430219016e-09 1.63837257675347 0.745098039215686 12.2 12 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.40489340770311e-09 1.06907129366927e-08 1.63745523488519 0.74468085106383 12.2 12 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 1.10656561372456e-06 5.42980299424156e-06 1.63141853355843 0.741935483870968 12.2 12 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.04709347123308e-17 5.82602801912935e-16 1.63141853355842 0.741935483870968 12.2 12 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.34739244276188e-11 2.25698611219606e-10 1.63019558113447 0.741379310344828 12.2 12 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.34739244276188e-11 2.25698611219606e-10 1.63019558113447 0.741379310344828 12.2 12 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 5.94560086101638e-06 2.5952730138731e-05 1.62879145057363 0.740740740740741 12.2 12 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 7.64910591697579e-14 1.0671252666526e-12 1.62656022940846 0.73972602739726 12.2 12 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.77319360555382e-08 1.11117320262529e-07 1.62297433825015 0.738095238095238 12.2 12 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000177032816492793 0.000589971189389333 1.62021886399166 0.736842105263158 12.2 12 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000177032816492793 0.000589971189389333 1.62021886399166 0.736842105263158 12.2 12 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.07112788519397e-28 8.96597047430008e-27 1.61879886498729 0.736196319018405 12.2 12 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 6.01432855700069e-16 1.11147916059896e-14 1.61755840608691 0.735632183908046 12.2 12 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 6.01432855700069e-16 1.11147916059896e-14 1.61755840608691 0.735632183908046 12.2 12 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.60936611081362e-14 2.60241815419066e-13 1.61435912126475 0.734177215189873 12.2 12 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.60936611081362e-14 2.60241815419066e-13 1.61435912126475 0.734177215189873 12.2 12 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000989813391850847 0.00272437999343086 1.61250353606789 0.733333333333333 12.2 12 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.1726582869546e-18 7.02657441440089e-17 1.60686541181591 0.730769230769231 12.2 12 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.42202931668837e-05 5.78156490756444e-05 1.60686541181591 0.730769230769231 12.2 12 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 3.89507200346545e-49 9.23781243488557e-47 1.60599948829598 0.73037542662116 12.2 12 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.63092791616151e-17 7.34080475430946e-16 1.5991770605632 0.727272727272727 12.2 12 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.17804433277126e-06 5.7606772698746e-06 1.5991770605632 0.727272727272727 12.2 12 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 7.70348809032593e-05 0.000275428732475724 1.5991770605632 0.727272727272727 12.2 12 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00569190326171517 0.0129386235485953 1.5991770605632 0.727272727272727 12.2 12 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00569190326171517 0.0129386235485953 1.5991770605632 0.727272727272727 12.2 12 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00569190326171517 0.0129386235485953 1.5991770605632 0.727272727272727 12.2 12 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00569190326171517 0.0129386235485953 1.5991770605632 0.727272727272727 12.2 12 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00569190326171517 0.0129386235485953 1.5991770605632 0.727272727272727 12.2 12 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.53602487342222e-19 1.57433253533654e-17 1.5991770605632 0.727272727272727 12.2 12 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.63158749760207e-09 1.22197316267776e-08 1.59525750894417 0.725490196078431 12.2 12 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.63158749760207e-09 1.22197316267776e-08 1.59525750894417 0.725490196078431 12.2 12 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 9.94687229448845e-08 5.59462421939014e-07 1.59417963224894 0.725 12.2 12 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.19239227359591e-42 2.12096775665872e-40 1.59228405599181 0.724137931034483 12.2 12 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 6.26995923063608e-06 2.69580169313135e-05 1.59228405599181 0.724137931034483 12.2 12 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 6.26995923063608e-06 2.69580169313135e-05 1.59228405599181 0.724137931034483 12.2 12 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 6.26995923063608e-06 2.69580169313135e-05 1.59228405599181 0.724137931034483 12.2 12 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.0801458995371e-12 1.21027371263094e-11 1.58807166430929 0.722222222222222 12.2 12 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 5.23513208707359e-07 2.66632840066915e-06 1.58807166430929 0.722222222222222 12.2 12 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 5.23513208707359e-07 2.66632840066915e-06 1.58807166430929 0.722222222222222 12.2 12 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000422423661820626 0.00128993319907887 1.58807166430929 0.722222222222222 12.2 12 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000422423661820626 0.00128993319907887 1.58807166430929 0.722222222222222 12.2 12 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 9.48873121505661e-14 1.28266830349403e-12 1.58652534331191 0.721518987341772 12.2 12 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.81356788581857e-09 2.47794844818257e-08 1.58318528995757 0.72 12.2 12 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.35815376390649e-05 0.000125423958163752 1.58318528995757 0.72 12.2 12 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.35815376390649e-05 0.000125423958163752 1.58318528995757 0.72 12.2 12 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 2.87245391927672e-11 2.72500128475384e-10 1.58043670438472 0.71875 12.2 12 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.05271017727915e-20 8.11390717296732e-19 1.5782201031163 0.717741935483871 12.2 12 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.05271017727915e-20 8.11390717296732e-19 1.5782201031163 0.717741935483871 12.2 12 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.05271017727915e-20 8.11390717296732e-19 1.5782201031163 0.717741935483871 12.2 12 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.93986449430972e-14 3.10160356786824e-13 1.57801148182045 0.717647058823529 12.2 12 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.98326291539619e-08 1.20606116607213e-07 1.57744911137076 0.717391304347826 12.2 12 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 9.94461151842327e-14 1.31029464728855e-12 1.57449840222117 0.716049382716049 12.2 12 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 9.94461151842327e-14 1.31029464728855e-12 1.57449840222117 0.716049382716049 12.2 12 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.73266646674125e-18 8.64129862705068e-17 1.57062032733886 0.714285714285714 12.2 12 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 1.46672027146008e-05 5.91701860818496e-05 1.57062032733886 0.714285714285714 12.2 12 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.46672027146008e-05 5.91701860818496e-05 1.57062032733886 0.714285714285714 12.2 12 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000181326879232182 0.000597287382285637 1.57062032733886 0.714285714285714 12.2 12 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000181326879232182 0.000597287382285637 1.57062032733886 0.714285714285714 12.2 12 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000181326879232182 0.000597287382285637 1.57062032733886 0.714285714285714 12.2 12 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0023569104949936 0.00590472470840826 1.57062032733886 0.714285714285714 12.2 12 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0023569104949936 0.00590472470840826 1.57062032733886 0.714285714285714 12.2 12 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0023569104949936 0.00590472470840826 1.57062032733886 0.714285714285714 12.2 12 2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0343916735936873 0.0646490773101942 1.57062032733886 0.714285714285714 12.2 12 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 1.2199705145071e-06 5.86492581805272e-06 1.57062032733886 0.714285714285714 12.2 12 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 7.1006990019781e-17 1.83714448723906e-15 1.56457947992601 0.711538461538462 12.2 12 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 4.5866834987199e-08 2.69704571019769e-07 1.56363979255068 0.711111111111111 12.2 12 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.17226090007854e-12 1.30322442250919e-11 1.56235390456339 0.710526315789474 12.2 12 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.19987180228262e-17 8.75657225893879e-16 1.56181311055004 0.710280373831776 12.2 12 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.33667616828973e-11 1.33013299823516e-10 1.56151528196298 0.710144927536232 12.2 12 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.52992501108796e-10 1.3356339207228e-09 1.56048729296893 0.709677419354839 12.2 12 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.63407417851845e-14 6.79823459384717e-13 1.55966251110161 0.709302325581395 12.2 12 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 2.03724621645238e-08 1.23361760255818e-07 1.55753182461103 0.708333333333333 12.2 12 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 7.82127536365127e-05 0.000276857583146163 1.55753182461103 0.708333333333333 12.2 12 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 7.82127536365127e-05 0.000276857583146163 1.55753182461103 0.708333333333333 12.2 12 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 7.82127536365127e-05 0.000276857583146163 1.55753182461103 0.708333333333333 12.2 12 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 7.82127536365127e-05 0.000276857583146163 1.55753182461103 0.708333333333333 12.2 12 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 2.81327398543525e-06 1.2913835100885e-05 1.55214244113487 0.705882352941177 12.2 12 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00098968970764707 0.00272437999343086 1.55214244113487 0.705882352941177 12.2 12 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00098968970764707 0.00272437999343086 1.55214244113487 0.705882352941177 12.2 12 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00098968970764707 0.00272437999343086 1.55214244113487 0.705882352941177 12.2 12 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00098968970764707 0.00272437999343086 1.55214244113487 0.705882352941177 12.2 12 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00098968970764707 0.00272437999343086 1.55214244113487 0.705882352941177 12.2 12 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00098968970764707 0.00272437999343086 1.55214244113487 0.705882352941177 12.2 12 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00098968970764707 0.00272437999343086 1.55214244113487 0.705882352941177 12.2 12 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00098968970764707 0.00272437999343086 1.55214244113487 0.705882352941177 12.2 12 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 9.05032081753803e-09 5.77515987594467e-08 1.55214244113487 0.705882352941177 12.2 12 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 5.24416351935607e-20 1.96380123369571e-18 1.5511397651393 0.705426356589147 12.2 12 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.49395897550708e-31 1.63531047857429e-29 1.54967872297434 0.704761904761905 12.2 12 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 3.38726873933185e-05 0.000126180194137938 1.54735187804495 0.703703703703704 12.2 12 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 8.69082682381614e-62 3.09176164257259e-59 1.54333725123015 0.7018779342723 12.2 12 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 5.64120095995334e-76 2.67580965533787e-73 1.54255220742063 0.701520912547528 12.2 12 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 6.95264542678981e-11 6.34010243951408e-10 1.54248981401338 0.701492537313433 12.2 12 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.73538811345523e-24 4.07683603164696e-22 1.53920792079208 0.7 12.2 12 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 5.43046564145978e-07 2.74026688219761e-06 1.53920792079208 0.7 12.2 12 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0135036888167577 0.0278893311846824 1.53920792079208 0.7 12.2 12 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 1.4719779250158e-05 5.91701860818496e-05 1.53920792079208 0.7 12.2 12 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.4719779250158e-05 5.91701860818496e-05 1.53920792079208 0.7 12.2 12 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.54137870997852e-27 3.75494376395211e-25 1.53800635332854 0.699453551912568 12.2 12 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 2.39072069483114e-07 1.28863467755482e-06 1.5340942732147 0.697674418604651 12.2 12 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.71588825037713e-16 3.65936146877497e-15 1.53315598925554 0.697247706422018 12.2 12 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 8.77097457104791e-23 4.30382648779351e-21 1.53211479673313 0.696774193548387 12.2 12 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.05373591177454e-07 5.84685934234335e-07 1.52964762314741 0.695652173913043 12.2 12 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.000179422223287915 0.000596536971352111 1.52964762314741 0.695652173913043 12.2 12 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 3.85405367339297e-16 7.70618419072861e-15 1.52699198491278 0.694444444444444 12.2 12 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 2.80282802768832e-06 1.29075219527524e-05 1.52699198491278 0.694444444444444 12.2 12 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.72296007314071e-16 3.65936146877497e-15 1.52534118276693 0.693693693693694 12.2 12 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00548196191382893 0.0127049377905188 1.52229354803612 0.692307692307692 12.2 12 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00548196191382893 0.0127049377905188 1.52229354803612 0.692307692307692 12.2 12 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 5.38321061039001e-07 2.72608850483452e-06 1.51826631642756 0.69047619047619 12.2 12 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 3.3327743790078e-05 0.000125132927211823 1.51646100570648 0.689655172413793 12.2 12 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 6.11259982834407e-12 6.25771910484433e-11 1.51172206506365 0.6875 12.2 12 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00227127794177542 0.0057818041344301 1.51172206506365 0.6875 12.2 12 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00227127794177542 0.0057818041344301 1.51172206506365 0.6875 12.2 12 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00227127794177542 0.0057818041344301 1.51172206506365 0.6875 12.2 12 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00227127794177542 0.0057818041344301 1.51172206506365 0.6875 12.2 12 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00227127794177542 0.0057818041344301 1.51172206506365 0.6875 12.2 12 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00227127794177542 0.0057818041344301 1.51172206506365 0.6875 12.2 12 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 6.28957246746035e-06 2.69580169313135e-05 1.5077955142453 0.685714285714286 12.2 12 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 6.28957246746035e-06 2.69580169313135e-05 1.5077955142453 0.685714285714286 12.2 12 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 6.28957246746035e-06 2.69580169313135e-05 1.5077955142453 0.685714285714286 12.2 12 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.06625916630738e-13 1.35472035147804e-12 1.50448894513512 0.684210526315789 12.2 12 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.06625916630738e-13 1.35472035147804e-12 1.50448894513512 0.684210526315789 12.2 12 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.06625916630738e-13 1.35472035147804e-12 1.50448894513512 0.684210526315789 12.2 12 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.34784822837041e-17 8.98865665843601e-16 1.50166626418739 0.682926829268293 12.2 12 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.20021428763805e-06 5.78950824172522e-06 1.50166626418739 0.682926829268293 12.2 12 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.20021428763805e-06 5.78950824172522e-06 1.50166626418739 0.682926829268293 12.2 12 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.20021428763805e-06 5.78950824172522e-06 1.50166626418739 0.682926829268293 12.2 12 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.20021428763805e-06 5.78950824172522e-06 1.50166626418739 0.682926829268293 12.2 12 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.91984119241373e-29 1.70745876050296e-27 1.499228494278 0.681818181818182 12.2 12 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000404809732794159 0.00125461014363005 1.499228494278 0.681818181818182 12.2 12 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.000404809732794159 0.00125461014363005 1.499228494278 0.681818181818182 12.2 12 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000404809732794159 0.00125461014363005 1.499228494278 0.681818181818182 12.2 12 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.42129692880507e-10 2.71983549144671e-09 1.49777996433184 0.681159420289855 12.2 12 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 3.21534227848592e-05 0.000121043176250938 1.48955605237943 0.67741935483871 12.2 12 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.69799951234385e-09 1.26505408694518e-08 1.48846480252421 0.676923076923077 12.2 12 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.01955075693958e-13 1.33102819002296e-12 1.48812309802409 0.676767676767677 12.2 12 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 1.39464960186833e-05 5.68649393541155e-05 1.48746983942092 0.676470588235294 12.2 12 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 1.39464960186833e-05 5.68649393541155e-05 1.48746983942092 0.676470588235294 12.2 12 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.50482977463587e-12 5.67635707920786e-11 1.4742413527067 0.670454545454545 12.2 12 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 8.46743671848766e-28 6.69397913911552e-26 1.46919910440756 0.668161434977579 12.2 12 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00016368763831778 0.000549357333316511 1.46591230551627 0.666666666666667 12.2 12 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00016368763831778 0.000549357333316511 1.46591230551627 0.666666666666667 12.2 12 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.1895306920166e-11 1.20049799626924e-10 1.46591230551627 0.666666666666667 12.2 12 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.81941922847289e-08 1.11117320262529e-07 1.46591230551627 0.666666666666667 12.2 12 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.81941922847289e-08 1.11117320262529e-07 1.46591230551627 0.666666666666667 12.2 12 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.81941922847289e-08 1.11117320262529e-07 1.46591230551627 0.666666666666667 12.2 12 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.81941922847289e-08 1.11117320262529e-07 1.46591230551627 0.666666666666667 12.2 12 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.81941922847289e-08 1.11117320262529e-07 1.46591230551627 0.666666666666667 12.2 12 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.81941922847289e-08 1.11117320262529e-07 1.46591230551627 0.666666666666667 12.2 12 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.81941922847289e-08 1.11117320262529e-07 1.46591230551627 0.666666666666667 12.2 12 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 2.52400074083615e-06 1.16991956163187e-05 1.46591230551627 0.666666666666667 12.2 12 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 3.05334256685426e-05 0.000115249508557921 1.46591230551627 0.666666666666667 12.2 12 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000381841162590723 0.00119419774586066 1.46591230551627 0.666666666666667 12.2 12 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000896721004839938 0.002593565020096 1.46591230551627 0.666666666666667 12.2 12 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000896721004839938 0.002593565020096 1.46591230551627 0.666666666666667 12.2 12 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000896721004839938 0.002593565020096 1.46591230551627 0.666666666666667 12.2 12 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00212422179929996 0.00552350620015163 1.46591230551627 0.666666666666667 12.2 12 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00212422179929996 0.00552350620015163 1.46591230551627 0.666666666666667 12.2 12 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00212422179929996 0.00552350620015163 1.46591230551627 0.666666666666667 12.2 12 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00212422179929996 0.00552350620015163 1.46591230551627 0.666666666666667 12.2 12 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0050911047012791 0.0118376503103271 1.46591230551627 0.666666666666667 12.2 12 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0050911047012791 0.0118376503103271 1.46591230551627 0.666666666666667 12.2 12 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0050911047012791 0.0118376503103271 1.46591230551627 0.666666666666667 12.2 12 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0050911047012791 0.0118376503103271 1.46591230551627 0.666666666666667 12.2 12 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0050911047012791 0.0118376503103271 1.46591230551627 0.666666666666667 12.2 12 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0124052752461735 0.0262801485935787 1.46591230551627 0.666666666666667 12.2 12 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0124052752461735 0.0262801485935787 1.46591230551627 0.666666666666667 12.2 12 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0124052752461735 0.0262801485935787 1.46591230551627 0.666666666666667 12.2 12 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0124052752461735 0.0262801485935787 1.46591230551627 0.666666666666667 12.2 12 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0124052752461735 0.0262801485935787 1.46591230551627 0.666666666666667 12.2 12 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0124052752461735 0.0262801485935787 1.46591230551627 0.666666666666667 12.2 12 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0124052752461735 0.0262801485935787 1.46591230551627 0.666666666666667 12.2 12 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.031000643880405 0.0592928981744842 1.46591230551627 0.666666666666667 12.2 12 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.031000643880405 0.0592928981744842 1.46591230551627 0.666666666666667 12.2 12 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.031000643880405 0.0592928981744842 1.46591230551627 0.666666666666667 12.2 12 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.031000643880405 0.0592928981744842 1.46591230551627 0.666666666666667 12.2 12 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 5.76044326329592e-11 5.3575887344249e-10 1.45708150849508 0.662650602409639 12.2 12 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.04789469273783e-25 1.26702354250693e-23 1.45544150333401 0.661904761904762 12.2 12 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 8.87701287949273e-08 5.05279573100726e-07 1.45282380278844 0.660714285714286 12.2 12 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 5.44051078921784e-06 2.38210672401753e-05 1.4480353261807 0.658536585365854 12.2 12 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 6.59420697075565e-05 0.000238767341460185 1.44300742574257 0.65625 12.2 12 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 6.38296074485062e-21 2.75241004240074e-19 1.44106633423633 0.655367231638418 12.2 12 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 4.29911869775487e-07 2.21653837206709e-06 1.43772168425634 0.653846153846154 12.2 12 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 4.29911869775487e-07 2.21653837206709e-06 1.43772168425634 0.653846153846154 12.2 12 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 4.29911869775487e-07 2.21653837206709e-06 1.43772168425634 0.653846153846154 12.2 12 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 4.29911869775487e-07 2.21653837206709e-06 1.43772168425634 0.653846153846154 12.2 12 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000354216948609255 0.00112511320953342 1.43772168425634 0.653846153846154 12.2 12 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000354216948609255 0.00112511320953342 1.43772168425634 0.653846153846154 12.2 12 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000354216948609255 0.00112511320953342 1.43772168425634 0.653846153846154 12.2 12 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 9.77274189338732e-07 4.82868462301742e-06 1.43599572785267 0.653061224489796 12.2 12 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.99467499929289e-09 1.97288079814527e-08 1.43537246581801 0.652777777777778 12.2 12 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.22482781895978e-06 1.04142433762492e-05 1.43404464670069 0.652173913043478 12.2 12 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.15920050499866e-05 4.78128208293649e-05 1.42926449787836 0.65 12.2 12 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.15920050499866e-05 4.78128208293649e-05 1.42926449787836 0.65 12.2 12 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00194639798470953 0.00511019249491081 1.42926449787836 0.65 12.2 12 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00194639798470953 0.00511019249491081 1.42926449787836 0.65 12.2 12 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00194639798470953 0.00511019249491081 1.42926449787836 0.65 12.2 12 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00194639798470953 0.00511019249491081 1.42926449787836 0.65 12.2 12 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00194639798470953 0.00511019249491081 1.42926449787836 0.65 12.2 12 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00194639798470953 0.00511019249491081 1.42926449787836 0.65 12.2 12 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00194639798470953 0.00511019249491081 1.42926449787836 0.65 12.2 12 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 2.65446400119259e-05 0.000101674072670349 1.42629305401583 0.648648648648649 12.2 12 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 6.09427966932849e-05 0.000221228570649348 1.42279723770696 0.647058823529412 12.2 12 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00462085637101073 0.0109591310265805 1.42279723770696 0.647058823529412 12.2 12 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00462085637101073 0.0109591310265805 1.42279723770696 0.647058823529412 12.2 12 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00462085637101073 0.0109591310265805 1.42279723770696 0.647058823529412 12.2 12 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.69250459278254e-06 2.10644606799039e-05 1.41704856199906 0.644444444444444 12.2 12 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0111070544677325 0.023911253415406 1.41355829460497 0.642857142857143 12.2 12 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0111070544677325 0.023911253415406 1.41355829460497 0.642857142857143 12.2 12 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0111070544677325 0.023911253415406 1.41355829460497 0.642857142857143 12.2 12 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.5787177251485e-91 2.24651532288632e-88 1.40787279115759 0.64027149321267 12.2 12 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.61413850829712e-11 1.59508270646305e-10 1.40727581329562 0.64 12.2 12 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000753018184741186 0.00224172568386341 1.40727581329562 0.64 12.2 12 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000753018184741186 0.00224172568386341 1.40727581329562 0.64 12.2 12 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.3594295404073e-27 1.67873411799979e-25 1.40389293874442 0.638461538461538 12.2 12 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 3.40812253588645e-07 1.78957873378834e-06 1.4027264302785 0.637931034482759 12.2 12 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 3.40812253588645e-07 1.78957873378834e-06 1.4027264302785 0.637931034482759 12.2 12 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 3.40812253588645e-07 1.78957873378834e-06 1.4027264302785 0.637931034482759 12.2 12 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.73636643377914e-08 1.64297444526064e-07 1.40217698788512 0.63768115942029 12.2 12 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.92600780245557e-54 8.32741820578854e-52 1.40002860639194 0.636704119850187 12.2 12 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00175756573092004 0.00469233777692162 1.3992799279928 0.636363636363636 12.2 12 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.027174313538082 0.0537817081567325 1.3992799279928 0.636363636363636 12.2 12 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.027174313538082 0.0537817081567325 1.3992799279928 0.636363636363636 12.2 12 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.027174313538082 0.0537817081567325 1.3992799279928 0.636363636363636 12.2 12 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.027174313538082 0.0537817081567325 1.3992799279928 0.636363636363636 12.2 12 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.027174313538082 0.0537817081567325 1.3992799279928 0.636363636363636 12.2 12 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 7.69594420417937e-07 3.82913587501652e-06 1.3992799279928 0.636363636363636 12.2 12 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000127907196775831 0.000435435265578967 1.3992799279928 0.636363636363636 12.2 12 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.000127907196775831 0.000435435265578967 1.3992799279928 0.636363636363636 12.2 12 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000127907196775831 0.000435435265578967 1.3992799279928 0.636363636363636 12.2 12 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000127907196775831 0.000435435265578967 1.3992799279928 0.636363636363636 12.2 12 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 2.22545951019857e-05 8.74814608567006e-05 1.39440438817401 0.634146341463415 12.2 12 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.8508215936844e-14 5.70804075813844e-13 1.39317619875401 0.633587786259542 12.2 12 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.8508215936844e-14 5.70804075813844e-13 1.39317619875401 0.633587786259542 12.2 12 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000294029088664877 0.000950916802659364 1.39261669024045 0.633333333333333 12.2 12 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 6.83760138931783e-11 6.31812128376577e-10 1.39112086135727 0.63265306122449 12.2 12 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 5.0685792913992e-05 0.000186776844843626 1.38875902627857 0.631578947368421 12.2 12 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00413013832376115 0.00996083063278521 1.38875902627857 0.631578947368421 12.2 12 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00413013832376115 0.00996083063278521 1.38875902627857 0.631578947368421 12.2 12 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00413013832376115 0.00996083063278521 1.38875902627857 0.631578947368421 12.2 12 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00413013832376115 0.00996083063278521 1.38875902627857 0.631578947368421 12.2 12 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.31312052726424e-12 2.49361402295228e-11 1.38875902627857 0.631578947368421 12.2 12 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.8575631483419e-19 1.01657809002263e-17 1.38752127313572 0.631016042780749 12.2 12 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.26526384381485e-07 6.97856763468423e-07 1.38697856598847 0.630769230769231 12.2 12 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 8.90207085400951e-06 3.75894564547642e-05 1.38624315847734 0.630434782608696 12.2 12 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 8.90207085400951e-06 3.75894564547642e-05 1.38624315847734 0.630434782608696 12.2 12 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000678116776104758 0.0020357809544242 1.38447273298758 0.62962962962963 12.2 12 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000678116776104758 0.0020357809544242 1.38447273298758 0.62962962962963 12.2 12 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 4.31121337290212e-32 5.11238052469976e-30 1.38272403050997 0.628834355828221 12.2 12 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000115639079136721 0.00039843682714662 1.38214588805819 0.628571428571429 12.2 12 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.24980756831454e-27 1.67873411799979e-25 1.3812386705406 0.628158844765343 12.2 12 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.3940355389944e-17 2.03634040667749e-15 1.38099665367234 0.628048780487805 12.2 12 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.01684475334495e-05 7.99434563791048e-05 1.38068484589323 0.627906976744186 12.2 12 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 4.14191869579966e-16 7.96479770827421e-15 1.3777720086656 0.626582278481013 12.2 12 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.6637774969138e-08 2.73109274819273e-07 1.3742927864215 0.625 12.2 12 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00979081596711856 0.0212437034971411 1.3742927864215 0.625 12.2 12 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00979081596711856 0.0212437034971411 1.3742927864215 0.625 12.2 12 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0683219791623923 0.11987937897421 1.3742927864215 0.625 12.2 12 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0683219791623923 0.11987937897421 1.3742927864215 0.625 12.2 12 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0683219791623923 0.11987937897421 1.3742927864215 0.625 12.2 12 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0683219791623923 0.11987937897421 1.3742927864215 0.625 12.2 12 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0683219791623923 0.11987937897421 1.3742927864215 0.625 12.2 12 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0683219791623923 0.11987937897421 1.3742927864215 0.625 12.2 12 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0683219791623923 0.11987937897421 1.3742927864215 0.625 12.2 12 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.44712001747605e-09 2.25011549764606e-08 1.3710591563358 0.623529411764706 12.2 12 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.2091120963182e-12 3.38264186152652e-11 1.36293499479818 0.619834710743802 12.2 12 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.2091120963182e-12 3.38264186152652e-11 1.36293499479818 0.619834710743802 12.2 12 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 5.03806109209683e-20 1.93761106325778e-18 1.36120428369368 0.619047619047619 12.2 12 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 5.20888493952718e-07 2.66632840066915e-06 1.36120428369368 0.619047619047619 12.2 12 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.63014982091582e-05 6.49776805367848e-05 1.35674862319059 0.617021276595745 12.2 12 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.09157538508187e-15 1.09725465480652e-13 1.35314982047655 0.615384615384615 12.2 12 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00139110016255228 0.00379221366151703 1.35314982047655 0.615384615384615 12.2 12 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00139110016255228 0.00379221366151703 1.35314982047655 0.615384615384615 12.2 12 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 1.88531499555029e-07 1.02789396117551e-06 1.35073348151142 0.614285714285714 12.2 12 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 3.66577343674726e-05 0.000135843635429462 1.3493056448502 0.613636363636364 12.2 12 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 3.66577343674726e-05 0.000135843635429462 1.3493056448502 0.613636363636364 12.2 12 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000537363610398395 0.00163390687520709 1.34769357120044 0.612903225806452 12.2 12 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000209677820219871 0.000684338390304761 1.34375294672324 0.611111111111111 12.2 12 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00854413926941337 0.0190270894841553 1.34375294672324 0.611111111111111 12.2 12 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00854413926941337 0.0190270894841553 1.34375294672324 0.611111111111111 12.2 12 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00854413926941337 0.0190270894841553 1.34375294672324 0.611111111111111 12.2 12 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.003204472603056 0.00791660505928591 1.33844167025398 0.608695652173913 12.2 12 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00122481060831706 0.00335174133775997 1.33502727823803 0.607142857142857 12.2 12 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00122481060831706 0.00335174133775997 1.33502727823803 0.607142857142857 12.2 12 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.33470473690339e-07 1.77062867187072e-06 1.33170906627886 0.605633802816901 12.2 12 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000163256105942413 0.000549357333316511 1.31932107496464 0.6 12.2 12 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.057246076475876 0.101953900907599 1.31932107496464 0.6 12.2 12 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.62817546004603e-07 1.41128063382849e-06 1.31932107496464 0.6 12.2 12 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 2.8370774361236e-09 1.97288079814527e-08 1.31932107496464 0.6 12.2 12 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00279554329954932 0.00696682682181906 1.31932107496464 0.6 12.2 12 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.38549670573862e-77 9.85780906133029e-75 1.30743529951451 0.594594594594595 12.2 12 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00242816690647593 0.00606189738230746 1.3030331604589 0.592592592592593 12.2 12 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00242816690647593 0.00606189738230746 1.3030331604589 0.592592592592593 12.2 12 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.50529809279066e-21 6.90980382593907e-20 1.3015361094933 0.591911764705882 12.2 12 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.68504766137729e-13 4.44391764588125e-12 1.29995996904273 0.591194968553459 12.2 12 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00638870591022073 0.0144533044677967 1.2993313617076 0.590909090909091 12.2 12 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00638870591022073 0.0144533044677967 1.2993313617076 0.590909090909091 12.2 12 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 7.96490426586172e-15 1.41675734629015e-13 1.29769286062096 0.590163934426229 12.2 12 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.33357213588272e-11 1.33013299823516e-10 1.29717419840648 0.589928057553957 12.2 12 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000814506298529866 0.00237508701395082 1.29345203427906 0.588235294117647 12.2 12 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.017176472532987 0.0346696743467241 1.29345203427906 0.588235294117647 12.2 12 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.017176472532987 0.0346696743467241 1.29345203427906 0.588235294117647 12.2 12 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.017176472532987 0.0346696743467241 1.29345203427906 0.588235294117647 12.2 12 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.017176472532987 0.0346696743467241 1.29345203427906 0.588235294117647 12.2 12 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.33550836945201e-12 1.46186800748478e-11 1.28850890548563 0.585987261146497 12.2 12 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.23355300856255e-11 2.1769492679346e-10 1.28790866841786 0.585714285714286 12.2 12 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 2.13632083050833e-06 1.01332818060445e-05 1.28790866841786 0.585714285714286 12.2 12 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.27104537438878e-12 3.42257174099649e-11 1.28749534727909 0.585526315789474 12.2 12 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.75066242140769e-10 2.9651070142573e-09 1.28714251216062 0.585365853658537 12.2 12 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000277353304988539 0.000901081627850891 1.28714251216062 0.585365853658537 12.2 12 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 9.54516098556571e-05 0.00033209692133154 1.28267326732673 0.583333333333333 12.2 12 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00549269472440415 0.0127091131590685 1.28267326732673 0.583333333333333 12.2 12 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.047850967146754 0.0866309494272657 1.28267326732673 0.583333333333333 12.2 12 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.047850967146754 0.0866309494272657 1.28267326732673 0.583333333333333 12.2 12 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.047850967146754 0.0866309494272657 1.28267326732673 0.583333333333333 12.2 12 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.047850967146754 0.0866309494272657 1.28267326732673 0.583333333333333 12.2 12 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 4.22276386749511e-11 3.95328485752997e-10 1.28135500086494 0.58273381294964 12.2 12 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 4.64298608802428e-06 2.09081303900587e-05 1.27993835630898 0.582089552238806 12.2 12 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 4.64298608802428e-06 2.09081303900587e-05 1.27993835630898 0.582089552238806 12.2 12 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00024098298162987 0.000784711173591088 1.27841189434558 0.581395348837209 12.2 12 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.22166480646846e-35 5.0938100217829e-33 1.27820402249284 0.58130081300813 12.2 12 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 8.30250770019687e-05 0.000293162989016877 1.27534370579915 0.58 12.2 12 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0146133905696852 0.0297494345932217 1.27302910742202 0.578947368421053 12.2 12 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 6.95371436874124e-11 6.34010243951408e-10 1.27220246514447 0.578571428571429 12.2 12 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.50554933530856e-05 9.71497739548796e-05 1.26714453527677 0.576271186440678 12.2 12 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.50554933530856e-05 9.71497739548796e-05 1.26714453527677 0.576271186440678 12.2 12 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 2.50554933530856e-05 9.71497739548796e-05 1.26714453527677 0.576271186440678 12.2 12 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 9.83443581406022e-17 2.2571616392593e-15 1.26458529359987 0.575107296137339 12.2 12 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0124105831727933 0.0262801485935787 1.25649626187109 0.571428571428571 12.2 12 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0124105831727933 0.0262801485935787 1.25649626187109 0.571428571428571 12.2 12 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.039983272724848 0.0730374802149662 1.25649626187109 0.571428571428571 12.2 12 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.039983272724848 0.0730374802149662 1.25649626187109 0.571428571428571 12.2 12 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.039983272724848 0.0730374802149662 1.25649626187109 0.571428571428571 12.2 12 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.039983272724848 0.0730374802149662 1.25649626187109 0.571428571428571 12.2 12 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.039983272724848 0.0730374802149662 1.25649626187109 0.571428571428571 12.2 12 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.039983272724848 0.0730374802149662 1.25649626187109 0.571428571428571 12.2 12 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 8.93007431321964e-08 5.06274730984524e-07 1.25335502121641 0.57 12.2 12 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000393012036727986 0.00122643887777176 1.249357078565 0.568181818181818 12.2 12 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00115517310803775 0.00317338095123112 1.24800642226385 0.567567567567568 12.2 12 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00344746550024958 0.00848744534057984 1.24602545968883 0.566666666666667 12.2 12 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 4.29743943311597e-06 1.94753385774651e-05 1.24409662770788 0.565789473684211 12.2 12 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.43657214812324e-09 4.14445346913094e-08 1.24362232476175 0.565573770491803 12.2 12 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.000338294927236858 0.00108178355383831 1.24283869380727 0.565217391304348 12.2 12 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0105282092095349 0.0227684524394653 1.24283869380727 0.565217391304348 12.2 12 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0105282092095349 0.0227684524394653 1.24283869380727 0.565217391304348 12.2 12 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 3.0179092894391e-05 0.000114215024438081 1.23686350777935 0.5625 12.2 12 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0334254745963621 0.0636739629861088 1.23686350777935 0.5625 12.2 12 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0334254745963621 0.0636739629861088 1.23686350777935 0.5625 12.2 12 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0334254745963621 0.0636739629861088 1.23686350777935 0.5625 12.2 12 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 6.44592171424169e-13 7.70802235240834e-12 1.23686350777935 0.5625 12.2 12 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.15186113321545e-09 2.06686561869382e-08 1.23269898418413 0.560606060606061 12.2 12 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.60233626667402e-05 0.000100355677709407 1.23269898418413 0.560606060606061 12.2 12 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 8.45501589958435e-10 6.61070748632337e-09 1.23013620043323 0.559440559440559 12.2 12 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00072778918291323 0.00217572270438136 1.22727541857176 0.558139534883721 12.2 12 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00756385068849562 0.0169501724877626 1.22159358793022 0.555555555555556 12.2 12 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 5.0479531877039e-06 2.24733664607232e-05 1.22159358793022 0.555555555555556 12.2 12 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0021426390881825 0.00552350620015163 1.22159358793022 0.555555555555556 12.2 12 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0279668891124539 0.0551967866948987 1.22159358793022 0.555555555555556 12.2 12 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0279668891124539 0.0551967866948987 1.22159358793022 0.555555555555556 12.2 12 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.114973648264877 0.182801677632312 1.22159358793022 0.555555555555556 12.2 12 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 5.10515031015128e-12 5.30264882579947e-11 1.21395862800566 0.552083333333333 12.2 12 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00640885611214395 0.0144758765834616 1.21316880456519 0.551724137931034 12.2 12 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.05768217068121e-05 4.4008237686531e-05 1.21219671417691 0.551282051282051 12.2 12 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.13510744048482e-08 1.28739741008894e-07 1.21197474078116 0.551181102362205 12.2 12 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 7.51185695968369e-09 4.81503263677022e-08 1.20080050558247 0.546099290780142 12.2 12 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0196368358878804 0.039356644321766 1.1993827954224 0.545454545454545 12.2 12 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0196368358878804 0.039356644321766 1.1993827954224 0.545454545454545 12.2 12 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0933321920012287 0.155131124780426 1.1993827954224 0.545454545454545 12.2 12 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0933321920012287 0.155131124780426 1.1993827954224 0.545454545454545 12.2 12 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0933321920012287 0.155131124780426 1.1993827954224 0.545454545454545 12.2 12 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0933321920012287 0.155131124780426 1.1993827954224 0.545454545454545 12.2 12 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0933321920012287 0.155131124780426 1.1993827954224 0.545454545454545 12.2 12 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0933321920012287 0.155131124780426 1.1993827954224 0.545454545454545 12.2 12 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.62126964876492e-05 6.48052446683282e-05 1.19685245197214 0.544303797468354 12.2 12 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.38960419922736e-05 5.68649393541155e-05 1.19444706375399 0.54320987654321 12.2 12 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0762807561437214 0.132213783182114 1.18400609291698 0.538461538461538 12.2 12 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0762807561437214 0.132213783182114 1.18400609291698 0.538461538461538 12.2 12 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0762807561437214 0.132213783182114 1.18400609291698 0.538461538461538 12.2 12 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0762807561437214 0.132213783182114 1.18400609291698 0.538461538461538 12.2 12 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0762807561437214 0.132213783182114 1.18400609291698 0.538461538461538 12.2 12 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0762807561437214 0.132213783182114 1.18400609291698 0.538461538461538 12.2 12 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0762807561437214 0.132213783182114 1.18400609291698 0.538461538461538 12.2 12 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0762807561437214 0.132213783182114 1.18400609291698 0.538461538461538 12.2 12 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.54018670718587e-33 7.88368568432549e-31 1.18321693089105 0.538102643856921 12.2 12 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.90180459132076e-09 1.97288079814527e-08 1.18189179632249 0.5375 12.2 12 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 2.09441083389733e-05 8.25580780231553e-05 1.17988063614724 0.536585365853659 12.2 12 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.53133946064362e-05 6.13829873942499e-05 1.17613894279793 0.534883720930233 12.2 12 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00170836945621828 0.00456956717330566 1.17272984441301 0.533333333333333 12.2 12 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00979330252573756 0.0212437034971411 1.17272984441301 0.533333333333333 12.2 12 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00824728490103464 0.0184526515946105 1.16814886845827 0.53125 12.2 12 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0069504500303924 0.0156247873511033 1.16410683085115 0.529411764705882 12.2 12 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0069504500303924 0.0156247873511033 1.16410683085115 0.529411764705882 12.2 12 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 2.65795889201474e-05 0.000101674072670349 1.16410683085115 0.529411764705882 12.2 12 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 2.65795889201474e-05 0.000101674072670349 1.16410683085115 0.529411764705882 12.2 12 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.000119328112938706 0.000410154359207196 1.16051390853371 0.527777777777778 12.2 12 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00417668420340832 0.00997218392860746 1.15440594059406 0.525 12.2 12 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000461417382628838 0.00140598915520522 1.15350476499641 0.524590163934426 12.2 12 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.98135077939368e-06 1.81005180801189e-05 1.14986699194166 0.522935779816514 12.2 12 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0295735195369845 0.0580456804153503 1.14723571736056 0.521739130434783 12.2 12 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 9.13592080745631e-05 0.000318637630122802 1.14015401540154 0.518518518518518 12.2 12 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.62516701442261e-09 1.22197316267776e-08 1.13850042002025 0.517766497461929 12.2 12 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.05596827194817e-07 5.84685934234335e-07 1.13489984943195 0.516129032258065 12.2 12 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0144474905040698 0.0294538380906753 1.13489984943195 0.516129032258065 12.2 12 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.6194207796896e-19 9.5575276140982e-18 1.13394561749577 0.515695067264574 12.2 12 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.000409506449608854 0.001258591096746 1.13177052999418 0.514705882352941 12.2 12 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 1.13488385729469e-05 4.70827909309136e-05 1.13025948789806 0.514018691588785 12.2 12 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.64241128315216e-32 4.71195568720502e-30 1.12899648113705 0.513444302176697 12.2 12 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00307643787385977 0.00761351494696078 1.1218716623849 0.510204081632653 12.2 12 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 1.82075591348462e-07 9.96513717264852e-07 1.12017827119639 0.509433962264151 12.2 12 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 1.82075591348462e-07 9.96513717264852e-07 1.12017827119639 0.509433962264151 12.2 12 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 3.05658498587769e-07 1.62903387075054e-06 1.10617922440798 0.503067484662577 12.2 12 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.70102069578116e-08 4.97251102413518e-07 1.0994342291372 0.5 12.2 12 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000818316324386338 0.00238131723844941 1.0994342291372 0.5 12.2 12 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.020647696107105 0.0412663926410259 1.0994342291372 0.5 12.2 12 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.020647696107105 0.0412663926410259 1.0994342291372 0.5 12.2 12 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0426677672910978 0.0778413241733747 1.0994342291372 0.5 12.2 12 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0621854889601743 0.110336596995421 1.0994342291372 0.5 12.2 12 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0919177419560431 0.155131124780426 1.0994342291372 0.5 12.2 12 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0919177419560431 0.155131124780426 1.0994342291372 0.5 12.2 12 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.112578239562594 0.180811326069494 1.0994342291372 0.5 12.2 12 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.112578239562594 0.180811326069494 1.0994342291372 0.5 12.2 12 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.112578239562594 0.180811326069494 1.0994342291372 0.5 12.2 12 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.112578239562594 0.180811326069494 1.0994342291372 0.5 12.2 12 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.138813416855703 0.218508287816002 1.0994342291372 0.5 12.2 12 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.172701220053877 0.26712373493116 1.0994342291372 0.5 12.2 12 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.172701220053877 0.26712373493116 1.0994342291372 0.5 12.2 12 2 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.172701220053877 0.26712373493116 1.0994342291372 0.5 12.2 12 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.172701220053877 0.26712373493116 1.0994342291372 0.5 12.2 12 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.172701220053877 0.26712373493116 1.0994342291372 0.5 12.2 12 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 9.00668328235898e-10 6.92784341124153e-09 1.09070856065198 0.496031746031746 12.2 12 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 9.00668328235898e-10 6.92784341124153e-09 1.09070856065198 0.496031746031746 12.2 12 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 9.00668328235898e-10 6.92784341124153e-09 1.09070856065198 0.496031746031746 12.2 12 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00429699145377497 0.0102422426109243 1.07944451588016 0.490909090909091 12.2 12 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.00508683266918753 0.0118376503103271 1.07869018707801 0.490566037735849 12.2 12 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00508683266918753 0.0118376503103271 1.07869018707801 0.490566037735849 12.2 12 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00714156489588423 0.0160290959729389 1.0769967958895 0.489795918367347 12.2 12 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000301748354076537 0.000967089882547101 1.07553348502552 0.489130434782609 12.2 12 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0168972025313896 0.0343005980059449 1.07124360787727 0.487179487179487 12.2 12 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0168972025313896 0.0343005980059449 1.07124360787727 0.487179487179487 12.2 12 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0240087869326554 0.0478494451052782 1.06802182259042 0.485714285714286 12.2 12 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0286722663984821 0.0563544683495028 1.06611804037547 0.484848484848485 12.2 12 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0286722663984821 0.0563544683495028 1.06611804037547 0.484848484848485 12.2 12 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000565762949561125 0.00171293761111804 1.06237464837977 0.48314606741573 12.2 12 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.19853432678089e-46 6.5021633528703e-44 1.06039686141445 0.482246610716591 12.2 12 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00693133290286041 0.0156247873511033 1.05871444287286 0.481481481481481 12.2 12 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0492980122860435 0.0890242023896446 1.05871444287286 0.481481481481481 12.2 12 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0492980122860435 0.0890242023896446 1.05871444287286 0.481481481481481 12.2 12 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00972190398464369 0.0211857111334578 1.05545685997171 0.48 12.2 12 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0592879242634665 0.105458395283641 1.05545685997171 0.48 12.2 12 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0115245056085016 0.0247724644726552 1.05362446958982 0.479166666666667 12.2 12 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 7.94952724189533e-06 3.38687942072367e-05 1.05163274091384 0.478260869565217 12.2 12 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0714753595513508 0.125257926898488 1.05163274091384 0.478260869565217 12.2 12 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0192807263162597 0.038752081282539 1.0470802182259 0.476190476190476 12.2 12 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.4955181277365e-11 2.38330355420741e-10 1.04652028228033 0.475935828877005 12.2 12 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 1.05383948781758e-05 4.39769381573143e-05 1.04514118078475 0.475308641975309 12.2 12 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.104820499229465 0.169307117370634 1.04156926970893 0.473684210526316 12.2 12 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.104820499229465 0.169307117370634 1.04156926970893 0.473684210526316 12.2 12 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.104820499229465 0.169307117370634 1.04156926970893 0.473684210526316 12.2 12 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 5.0795951478906e-05 0.000186776844843626 1.03749427256609 0.471830985915493 12.2 12 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 5.94535574422875e-05 0.000216374455857737 1.03660941604365 0.471428571428571 12.2 12 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 2.60033036931245e-05 0.000100355677709407 1.03559611260665 0.470967741935484 12.2 12 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 5.24646487833705e-07 2.66632840066915e-06 1.035341650757 0.47085201793722 12.2 12 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00163423664437598 0.00441274904164519 1.03476162742325 0.470588235294118 12.2 12 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00163423664437598 0.00441274904164519 1.03476162742325 0.470588235294118 12.2 12 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00163423664437598 0.00441274904164519 1.03476162742325 0.470588235294118 12.2 12 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00163423664437598 0.00441274904164519 1.03476162742325 0.470588235294118 12.2 12 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00163423664437598 0.00441274904164519 1.03476162742325 0.470588235294118 12.2 12 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.127661866434607 0.201847595484939 1.03476162742325 0.470588235294118 12.2 12 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00192087152318512 0.00510915921026623 1.03320325147833 0.469879518072289 12.2 12 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00225813911320776 0.0057818041344301 1.03156791869663 0.469135802469136 12.2 12 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.000106545086835626 0.000369789411139257 1.02720862284351 0.467153284671533 12.2 12 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.156246541938187 0.243525552221293 1.02613861386139 0.466666666666667 12.2 12 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00182556700937531 0.00486476002685593 1.0244728044233 0.465909090909091 12.2 12 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0663952243023076 0.117512940525104 1.02090321277026 0.464285714285714 12.2 12 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.000161877865769401 0.00054715487646047 1.01859347699476 0.463235294117647 12.2 12 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0796925178670505 0.137791558839384 1.01486236535741 0.461538461538462 12.2 12 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0796925178670505 0.137791558839384 1.01486236535741 0.461538461538462 12.2 12 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.192412840323116 0.291280289127441 1.01486236535741 0.461538461538462 12.2 12 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.192412840323116 0.291280289127441 1.01486236535741 0.461538461538462 12.2 12 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.192412840323116 0.291280289127441 1.01486236535741 0.461538461538462 12.2 12 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.000208985501888697 0.000683646825718656 1.01115848811158 0.45985401459854 12.2 12 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.000412326567409901 0.00126452738237993 1.01077017840033 0.459677419354839 12.2 12 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0958510145407956 0.158556624555638 1.00781471004243 0.458333333333333 12.2 12 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0958510145407956 0.158556624555638 1.00781471004243 0.458333333333333 12.2 12 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.028319072549593 0.055814460163533 1.00383125269049 0.456521739130435 12.2 12 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.238842076764417 0.347162691762784 0.999485662852 0.454545454545455 12.2 12 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.238842076764417 0.347162691762784 0.999485662852 0.454545454545455 12.2 12 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.238842076764417 0.347162691762784 0.999485662852 0.454545454545455 12.2 12 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.238842076764417 0.347162691762784 0.999485662852 0.454545454545455 12.2 12 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.238842076764417 0.347162691762784 0.999485662852 0.454545454545455 12.2 12 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.000721073481993896 0.00216018434711013 0.999485662851999 0.454545454545455 12.2 12 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.018824906880414 0.0379431196753955 0.999485662851999 0.454545454545455 12.2 12 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0610435900721735 0.108445728680029 0.999485662851999 0.454545454545455 12.2 12 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 7.90085594934594e-13 9.36909834659939e-12 0.997385167588563 0.453590192644483 12.2 12 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.139703689449794 0.219424227469158 0.98949080622348 0.45 12.2 12 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.139703689449794 0.219424227469158 0.98949080622348 0.45 12.2 12 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0308887841626925 0.0592928981744842 0.98724706289871 0.448979591836735 12.2 12 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00923066506608396 0.020523806857871 0.983704310280652 0.447368421052632 12.2 12 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0557957464664812 0.100602783102824 0.983704310280652 0.447368421052632 12.2 12 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00577573114581036 0.0131082383101884 0.977274870344177 0.444444444444444 12.2 12 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0430355484300383 0.0784117610959596 0.977274870344177 0.444444444444444 12.2 12 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0662064872018844 0.117324821031484 0.977274870344177 0.444444444444444 12.2 12 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.169435907804001 0.263793541362246 0.977274870344177 0.444444444444444 12.2 12 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.000545069114414229 0.00165380245162356 0.966381679114226 0.439490445859873 12.2 12 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.046190938628436 0.0840533320566041 0.96200495049505 0.4375 12.2 12 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.206280053035411 0.311941036630595 0.96200495049505 0.4375 12.2 12 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00416492918236627 0.00996083063278521 0.959506236337919 0.436363636363636 12.2 12 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.149470553491622 0.233219953529142 0.95602976446713 0.434782608695652 12.2 12 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00303326463710869 0.00751974839478339 0.955246133512649 0.434426229508197 12.2 12 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.111090933176161 0.179231743661766 0.952842998585573 0.433333333333333 12.2 12 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.132217795854018 0.208819004994748 0.942372196403314 0.428571428571429 12.2 12 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.252288790893508 0.364844460814494 0.942372196403314 0.428571428571429 12.2 12 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.252288790893508 0.364844460814494 0.942372196403314 0.428571428571429 12.2 12 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.252288790893508 0.364844460814494 0.942372196403314 0.428571428571429 12.2 12 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.252288790893508 0.364844460814494 0.942372196403314 0.428571428571429 12.2 12 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.11726939844875 0.186036069111006 0.932853285328533 0.424242424242424 12.2 12 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.11726939844875 0.186036069111006 0.932853285328533 0.424242424242424 12.2 12 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.138734225248891 0.218508287816002 0.922106127663458 0.419354838709677 12.2 12 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0190934784008797 0.0384300138111059 0.922106127663457 0.419354838709677 12.2 12 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.310291119556356 0.437839370218005 0.916195190947666 0.416666666666667 12.2 12 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.310291119556356 0.437839370218005 0.916195190947666 0.416666666666667 12.2 12 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00342728483141927 0.00845238529481736 0.907672444985362 0.412790697674419 12.2 12 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.127441693068335 0.201723614278355 0.902099880317702 0.41025641025641 12.2 12 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.127441693068335 0.201723614278355 0.902099880317702 0.41025641025641 12.2 12 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 9.24542746524115e-06 3.89237966953792e-05 0.888431700312888 0.404040404040404 12.2 12 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0207590764783471 0.0414308076138681 0.88301016828342 0.401574803149606 12.2 12 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.267579094069879 0.386563503412627 0.87954738330976 0.4 12.2 12 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.0356414278610976 0.0659004782312101 0.87954738330976 0.4 12.2 12 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.229897602350269 0.340447585585224 0.879547383309759 0.4 12.2 12 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.229897602350269 0.340447585585224 0.879547383309759 0.4 12.2 12 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.229897602350269 0.340447585585224 0.879547383309759 0.4 12.2 12 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0558511585743016 0.100602783102824 0.8745499549955 0.397727272727273 12.2 12 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.13865228226267 0.218508287816002 0.870385431400283 0.395833333333333 12.2 12 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.234419711580091 0.343188528372911 0.863841180036371 0.392857142857143 12.2 12 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.234419711580091 0.343188528372911 0.863841180036371 0.392857142857143 12.2 12 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.272007089514106 0.392561955759202 0.860426788020417 0.391304347826087 12.2 12 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.319779886470865 0.446124292596118 0.855115511551155 0.388888888888889 12.2 12 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.319779886470865 0.446124292596118 0.855115511551155 0.388888888888889 12.2 12 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.319779886470865 0.446124292596118 0.855115511551155 0.388888888888889 12.2 12 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.237943766833887 0.347162691762784 0.851174887073961 0.387096774193548 12.2 12 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.237943766833887 0.347162691762784 0.851174887073961 0.387096774193548 12.2 12 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.383965044077132 0.513957858324798 0.845718637797846 0.384615384615385 12.2 12 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.383965044077132 0.513957858324798 0.845718637797846 0.384615384615385 12.2 12 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.383965044077132 0.513957858324798 0.845718637797846 0.384615384615385 12.2 12 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.383965044077132 0.513957858324798 0.845718637797846 0.384615384615385 12.2 12 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0881302589815852 0.150011194414827 0.842119835083812 0.382978723404255 12.2 12 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.212705051816305 0.321315593136519 0.837664174580723 0.380952380952381 12.2 12 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0123639158206097 0.0262801485935787 0.836432315500458 0.380392156862745 12.2 12 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.277355946997476 0.399875899267891 0.834053553138565 0.379310344827586 12.2 12 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.242833023640378 0.352603461877814 0.832004281509232 0.378378378378378 12.2 12 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.170946514023452 0.265854523994943 0.829081549841167 0.377049180327869 12.2 12 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.216300639492867 0.325905399060791 0.8245756718529 0.375 12.2 12 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.216300639492867 0.325905399060791 0.8245756718529 0.375 12.2 12 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.382339099160709 0.513957858324798 0.8245756718529 0.375 12.2 12 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.322724840154008 0.448474069862455 0.814395725286814 0.37037037037037 12.2 12 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.322724840154008 0.448474069862455 0.814395725286814 0.37037037037037 12.2 12 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.322724840154008 0.448474069862455 0.814395725286814 0.37037037037037 12.2 12 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.322407242286106 0.448474069862455 0.806251768033946 0.366666666666667 12.2 12 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.374665737303131 0.511169074000341 0.791592644978783 0.36 12.2 12 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0729709515283405 0.127721603966579 0.785940934885227 0.357429718875502 12.2 12 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.457118518068032 0.610206051792505 0.785310163669428 0.357142857142857 12.2 12 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.315470566030556 0.441410634672056 0.778765912305516 0.354166666666667 12.2 12 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.440638861833337 0.588759718674966 0.76960396039604 0.35 12.2 12 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.227668613509255 0.340447585585224 0.748803853358309 0.340540540540541 12.2 12 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.463139136056443 0.6170851971988 0.732956152758133 0.333333333333333 12.2 12 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.463139136056443 0.6170851971988 0.732956152758133 0.333333333333333 12.2 12 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.489270952512187 0.644659782800779 0.732956152758133 0.333333333333333 12.2 12 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.512640236373142 0.664378011255903 0.732956152758133 0.333333333333333 12.2 12 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.527519298670187 0.667846941287969 0.732956152758133 0.333333333333333 12.2 12 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.103983832579332 0.168529605649646 0.71543671300928 0.325365853658537 12.2 12 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.509628303287826 0.661076641366068 0.711398618853482 0.323529411764706 12.2 12 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.480246380180273 0.633355513435151 0.709312405894967 0.32258064516129 12.2 12 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.530766162517295 0.671360221566321 0.706779147302485 0.321428571428571 12.2 12 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.500635194692681 0.650306522789781 0.705297430012543 0.320754716981132 12.2 12 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.516264924793142 0.667846941287969 0.70176652923651 0.319148936170213 12.2 12 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.500763518979994 0.650306522789781 0.701088493942562 0.318840579710145 12.2 12 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.500868551635699 0.650306522789781 0.698464098510691 0.317647058823529 12.2 12 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.500868551635699 0.650306522789781 0.698464098510691 0.317647058823529 12.2 12 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.495697353151626 0.64839430359548 0.697717876183223 0.317307692307692 12.2 12 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.534094557044049 0.674970297223519 0.697202194087005 0.317073170731707 12.2 12 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.594692388042783 0.742973896562669 0.676574910238277 0.307692307692308 12.2 12 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.594692388042783 0.742973896562669 0.676574910238277 0.307692307692308 12.2 12 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.594692388042783 0.742973896562669 0.676574910238277 0.307692307692308 12.2 12 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.613652667513692 0.759328474671291 0.670386725083658 0.304878048780488 12.2 12 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.608877884878247 0.754075918347907 0.668010670868172 0.30379746835443 12.2 12 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.630908271565157 0.778649150422566 0.65966053748232 0.3 12.2 12 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.630908271565157 0.778649150422566 0.65966053748232 0.3 12.2 12 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.652499996068989 0.801819943355934 0.652789073550212 0.296875 12.2 12 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.683035689651616 0.823223429117751 0.648087545596665 0.294736842105263 12.2 12 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.653992317353406 0.802268161718876 0.646726017139529 0.294117647058824 12.2 12 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.653992317353406 0.802268161718876 0.646726017139529 0.294117647058824 12.2 12 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.683223380033776 0.823223429117751 0.628248130935543 0.285714285714286 12.2 12 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.720607339361938 0.862425772844439 0.621419346903634 0.282608695652174 12.2 12 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.797971802058388 0.936432134752876 0.612056168798029 0.278350515463918 12.2 12 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.708358502345815 0.851346409491634 0.610796793965111 0.277777777777778 12.2 12 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.730420857105875 0.873436033329126 0.5996913977112 0.272727272727273 12.2 12 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.766580181258141 0.913999691543394 0.586364922206506 0.266666666666667 12.2 12 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.766580181258141 0.913999691543394 0.586364922206506 0.266666666666667 12.2 12 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.846278754231253 0.975421919217721 0.58450933700965 0.265822784810127 12.2 12 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.756405307238744 0.903748742401959 0.578649594282737 0.263157894736842 12.2 12 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.798237652463274 0.936432134752876 0.5497171145686 0.25 12.2 12 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.798237652463274 0.936432134752876 0.5497171145686 0.25 12.2 12 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.898976446120282 1 0.540705358592065 0.245901639344262 12.2 12 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.862933592141911 0.993490697101893 0.534859895255935 0.243243243243243 12.2 12 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.994132612540134 1 0.534626840835344 0.243137254901961 12.2 12 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.949845047097227 1 0.533059020187733 0.242424242424242 12.2 12 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.841292521611406 0.975421919217721 0.527728429985856 0.24 12.2 12 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.873589921248027 1 0.513069306930693 0.233333333333333 12.2 12 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.864696893624438 0.99471598999804 0.499742831426 0.227272727272727 12.2 12 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.895041963300247 1 0.496518684126477 0.225806451612903 12.2 12 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.968527818170119 1 0.462919675426189 0.210526315789474 12.2 12 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.911664155923309 1 0.458097595473833 0.208333333333333 12.2 12 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.928470231716406 1 0.454938301711945 0.206896551724138 12.2 12 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999106960999 1 0.453374939850392 0.206185567010309 12.2 12 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.967913772163839 1 0.448748664953959 0.204081632653061 12.2 12 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.929257064501284 1 0.43977369165488 0.2 12.2 12 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999946491063228 1 0.435720477906909 0.19815668202765 12.2 12 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.98963428358888 1 0.433579695997769 0.197183098591549 12.2 12 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.968279501027329 1 0.429047504053541 0.195121951219512 12.2 12 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.953505912381482 1 0.42558744353698 0.193548387096774 12.2 12 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.953505912381482 1 0.42558744353698 0.193548387096774 12.2 12 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999997871364158 1 0.424067488381491 0.192857142857143 12.2 12 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.989847811417619 1 0.418832087290362 0.19047619047619 12.2 12 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999956062710168 1 0.413765570105398 0.188172043010753 12.2 12 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.979178215597696 1 0.409091806190586 0.186046511627907 12.2 12 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.975117750885255 1 0.405054715997916 0.184210526315789 12.2 12 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.976449162328182 1 0.388035610283717 0.176470588235294 12.2 12 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.981378520149393 1 0.376948878561325 0.171428571428571 12.2 12 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.365554957798767 0.16624685138539 12.2 12 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999056487256 1 0.3498199819982 0.159090909090909 12.2 12 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.992974784888621 1 0.338287455119138 0.153846153846154 12.2 12 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.997680496153538 1 0.320668316831683 0.145833333333333 12.2 12 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.300207176491351 0.136528028933092 12.2 12 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999952948003 1 0.223958824453874 0.101851851851852 12.2 12 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999997901347 1 0.146591230551627 0.0666666666666667 12.2 12 2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.000401683926193929 0.00160560737914034 3.77668262461278 1 12.5 12 5 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 6.24533894133232e-06 3.8978584708403e-05 3.39901436215151 0.9 12.5 12 5 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.000482821268743556 0.001908485181728 3.23715653538239 0.857142857142857 12.5 12 5 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 6.9687624479015e-06 4.29287833911855e-05 3.14723552051065 0.833333333333333 12.5 12 5 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00198987436051887 0.00642084175741124 3.14723552051065 0.833333333333333 12.5 12 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.00198987436051887 0.00642084175741124 3.14723552051065 0.833333333333333 12.5 12 5 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 1.09122931577877e-07 1.07834674746749e-06 3.11020922026935 0.823529411764706 12.5 12 5 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000109763547606534 0.000524139356523819 3.02134609969023 0.8 12.5 12 5 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 6.47629289056375e-06 4.02435143374333e-05 2.96739349076719 0.785714285714286 12.5 12 5 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.000422813115629165 0.00168533071019692 2.93741981914328 0.777777777777778 12.5 12 5 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 5.44212175330597e-06 3.45720502453321e-05 2.83251196845959 0.75 12.5 12 5 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00158652870964791 0.00529960176955158 2.83251196845959 0.75 12.5 12 5 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.000328069329399754 0.00136904004614619 2.74667827244566 0.727272727272727 12.5 12 5 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00575750708995716 0.016159630353075 2.69763044615199 0.714285714285714 12.5 12 5 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00575750708995716 0.016159630353075 2.69763044615199 0.714285714285714 12.5 12 5 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00575750708995716 0.016159630353075 2.69763044615199 0.714285714285714 12.5 12 5 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.00575750708995716 0.016159630353075 2.69763044615199 0.714285714285714 12.5 12 5 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00575750708995716 0.016159630353075 2.69763044615199 0.714285714285714 12.5 12 5 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 2.09357794008536e-07 1.75244788749498e-06 2.67515019243406 0.708333333333333 12.5 12 5 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00115326210768197 0.00399292452367749 2.64367783722895 0.7 12.5 12 5 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00115326210768197 0.00399292452367749 2.64367783722895 0.7 12.5 12 5 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00115326210768197 0.00399292452367749 2.64367783722895 0.7 12.5 12 5 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00115326210768197 0.00399292452367749 2.64367783722895 0.7 12.5 12 5 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.09223333904535e-05 0.000258794572909341 2.59646930442129 0.6875 12.5 12 5 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.09223333904535e-05 0.000258794572909341 2.59646930442129 0.6875 12.5 12 5 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 5.09223333904535e-05 0.000258794572909341 2.59646930442129 0.6875 12.5 12 5 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 5.09223333904535e-05 0.000258794572909341 2.59646930442129 0.6875 12.5 12 5 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 5.09223333904535e-05 0.000258794572909341 2.59646930442129 0.6875 12.5 12 5 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 5.09223333904535e-05 0.000258794572909341 2.59646930442129 0.6875 12.5 12 5 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.16236061485936e-07 1.14071665858267e-06 2.56274892384439 0.678571428571429 12.5 12 5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 8.42314335307975e-08 8.50080354002304e-07 2.51778841640852 0.666666666666667 12.5 12 5 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 8.42314335307975e-08 8.50080354002304e-07 2.51778841640852 0.666666666666667 12.5 12 5 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.72345404546801e-06 1.28401838047172e-05 2.51778841640852 0.666666666666667 12.5 12 5 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 7.87055902648131e-06 4.74568029435716e-05 2.51778841640852 0.666666666666667 12.5 12 5 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000169154771262415 0.000742923578723509 2.51778841640852 0.666666666666667 12.5 12 5 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000802829527414055 0.00291435310589337 2.51778841640852 0.666666666666667 12.5 12 5 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.000802829527414055 0.00291435310589337 2.51778841640852 0.666666666666667 12.5 12 5 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000802829527414055 0.00291435310589337 2.51778841640852 0.666666666666667 12.5 12 5 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.000802829527414055 0.00291435310589337 2.51778841640852 0.666666666666667 12.5 12 5 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000802829527414055 0.00291435310589337 2.51778841640852 0.666666666666667 12.5 12 5 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 3.62662403378036e-05 0.000196223802284009 2.51778841640852 0.666666666666667 12.5 12 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00391395989768539 0.0116032602800132 2.51778841640852 0.666666666666667 12.5 12 5 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00391395989768539 0.0116032602800132 2.51778841640852 0.666666666666667 12.5 12 5 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00391395989768539 0.0116032602800132 2.51778841640852 0.666666666666667 12.5 12 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00391395989768539 0.0116032602800132 2.51778841640852 0.666666666666667 12.5 12 5 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00391395989768539 0.0116032602800132 2.51778841640852 0.666666666666667 12.5 12 5 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 2.14562334311085e-09 3.50945059453648e-08 2.45484370599831 0.65 12.5 12 5 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 2.53330637096524e-05 0.000140816209604826 2.45484370599831 0.65 12.5 12 5 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 4.25761955563087e-08 4.61933654865598e-07 2.44373581592592 0.647058823529412 12.5 12 5 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000545971702114463 0.002116942049343 2.42786740153679 0.642857142857143 12.5 12 5 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000545971702114463 0.002116942049343 2.42786740153679 0.642857142857143 12.5 12 5 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.000545971702114463 0.002116942049343 2.42786740153679 0.642857142857143 12.5 12 5 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 1.74553509684887e-05 9.93558577126375e-05 2.40334348838995 0.636363636363636 12.5 12 5 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00259734946967586 0.00803484412032337 2.40334348838995 0.636363636363636 12.5 12 5 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00259734946967586 0.00803484412032337 2.40334348838995 0.636363636363636 12.5 12 5 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00259734946967586 0.00803484412032337 2.40334348838995 0.636363636363636 12.5 12 5 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00259734946967586 0.00803484412032337 2.40334348838995 0.636363636363636 12.5 12 5 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00259734946967586 0.00803484412032337 2.40334348838995 0.636363636363636 12.5 12 5 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00259734946967586 0.00803484412032337 2.40334348838995 0.636363636363636 12.5 12 5 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.69174260767165e-09 6.81260176603751e-08 2.39496946926664 0.634146341463415 12.5 12 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.69174260767165e-09 6.81260176603751e-08 2.39496946926664 0.634146341463415 12.5 12 5 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 7.96111586611121e-05 0.000391995428286376 2.38527323659755 0.631578947368421 12.5 12 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 2.65134990863995e-06 1.81388024999743e-05 2.37791128216361 0.62962962962963 12.5 12 5 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 2.65134990863995e-06 1.81388024999743e-05 2.37791128216361 0.62962962962963 12.5 12 5 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000366208834382352 0.00150177282802907 2.36042664038299 0.625 12.5 12 5 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0127091377238059 0.032410578818953 2.36042664038299 0.625 12.5 12 5 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.248336211665e-09 3.62516483092913e-08 2.34993585531462 0.622222222222222 12.5 12 5 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 5.37096338198054e-05 0.000268715367688088 2.33794638666506 0.619047619047619 12.5 12 5 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.5450209837401e-09 2.55647076728158e-08 2.33029353433555 0.617021276595745 12.5 12 5 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 8.85414657191587e-12 2.21042992488356e-10 2.32895428517788 0.616666666666667 12.5 12 5 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 8.85414657191587e-12 2.21042992488356e-10 2.32895428517788 0.616666666666667 12.5 12 5 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 8.85414657191587e-12 2.21042992488356e-10 2.32895428517788 0.616666666666667 12.5 12 5 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 8.85414657191587e-12 2.21042992488356e-10 2.32895428517788 0.616666666666667 12.5 12 5 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 8.85414657191587e-12 2.21042992488356e-10 2.32895428517788 0.616666666666667 12.5 12 5 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 8.85414657191587e-12 2.21042992488356e-10 2.32895428517788 0.616666666666667 12.5 12 5 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 8.85414657191587e-12 2.21042992488356e-10 2.32895428517788 0.616666666666667 12.5 12 5 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 5.16571497050094e-14 2.72252311223068e-12 2.32809202887089 0.616438356164384 12.5 12 5 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00170389951965379 0.00562563576906577 2.3241123843771 0.615384615384615 12.5 12 5 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00170389951965379 0.00562563576906577 2.3241123843771 0.615384615384615 12.5 12 5 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00170389951965379 0.00562563576906577 2.3241123843771 0.615384615384615 12.5 12 5 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00170389951965379 0.00562563576906577 2.3241123843771 0.615384615384615 12.5 12 5 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000243522311508317 0.0010500977250798 2.30797271504115 0.611111111111111 12.5 12 5 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000243522311508317 0.0010500977250798 2.30797271504115 0.611111111111111 12.5 12 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 5.42793417582659e-06 3.45720502453321e-05 2.29298587922919 0.607142857142857 12.5 12 5 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 3.12002707565414e-09 4.87889948203938e-08 2.28174575237022 0.604166666666667 12.5 12 5 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 5.58414749140838e-07 4.39018888412935e-06 2.26600957476767 0.6 12.5 12 5 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 5.58414749140838e-07 4.39018888412935e-06 2.26600957476767 0.6 12.5 12 5 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 5.58414749140838e-07 4.39018888412935e-06 2.26600957476767 0.6 12.5 12 5 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 5.58414749140838e-07 4.39018888412935e-06 2.26600957476767 0.6 12.5 12 5 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00111119709839253 0.00388509452337242 2.26600957476767 0.6 12.5 12 5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000161028301088302 0.000709421896125861 2.26600957476767 0.6 12.5 12 5 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000161028301088302 0.000709421896125861 2.26600957476767 0.6 12.5 12 5 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00805500658269049 0.0217913961353015 2.26600957476767 0.6 12.5 12 5 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 5.62816953674341e-12 1.66851776058039e-10 2.25473589529122 0.597014925373134 12.5 12 5 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 1.42663537788511e-09 2.38835546203589e-08 2.25148387236531 0.596153846153846 12.5 12 5 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.80714499902783e-12 1.2039038519148e-10 2.24411576245108 0.594202898550725 12.5 12 5 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.4296097222304e-06 1.68650469987018e-05 2.24240530836384 0.59375 12.5 12 5 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 6.11080910056182e-09 8.60958549514799e-08 2.23517951252593 0.591836734693878 12.5 12 5 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000722413135541739 0.00266319661107745 2.22157801447811 0.588235294117647 12.5 12 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.05524425299371e-05 6.25671905004188e-05 2.21391740063508 0.586206896551724 12.5 12 5 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.11314339746774e-20 1.32000254549716e-18 2.20790676515824 0.584615384615385 12.5 12 5 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.07510396517626e-06 8.18113872965679e-06 2.20306486435746 0.583333333333333 12.5 12 5 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0051096773888424 0.0148692656939115 2.20306486435746 0.583333333333333 12.5 12 5 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0051096773888424 0.0148692656939115 2.20306486435746 0.583333333333333 12.5 12 5 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0051096773888424 0.0148692656939115 2.20306486435746 0.583333333333333 12.5 12 5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0051096773888424 0.0148692656939115 2.20306486435746 0.583333333333333 12.5 12 5 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000468900146673223 0.00185862091564345 2.18650046688109 0.578947368421053 12.5 12 5 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000468900146673223 0.00185862091564345 2.18650046688109 0.578947368421053 12.5 12 5 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 7.74617655825926e-09 1.07017565460223e-07 2.17885536035353 0.576923076923077 12.5 12 5 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.57103619649656e-05 0.000238263168777092 2.17885536035353 0.576923076923077 12.5 12 5 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 4.57103619649656e-05 0.000238263168777092 2.17885536035353 0.576923076923077 12.5 12 5 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.90919805694684e-08 5.21327525002639e-07 2.16958363541586 0.574468085106383 12.5 12 5 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 2.99411059470557e-05 0.00016450267862031 2.15810435692159 0.571428571428571 12.5 12 5 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000304119857446299 0.00127658571429523 2.15810435692159 0.571428571428571 12.5 12 5 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000304119857446299 0.00127658571429523 2.15810435692159 0.571428571428571 12.5 12 5 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00324780327637291 0.00993897647801859 2.15810435692159 0.571428571428571 12.5 12 5 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00324780327637291 0.00993897647801859 2.15810435692159 0.571428571428571 12.5 12 5 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00324780327637291 0.00993897647801859 2.15810435692159 0.571428571428571 12.5 12 5 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 3.03089156956227e-06 2.03441448277694e-05 2.15810435692159 0.571428571428571 12.5 12 5 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.56128604860415e-11 5.97493450354706e-10 2.15061093901561 0.569444444444444 12.5 12 5 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.06266517623854e-07 1.73678848863163e-06 2.14584240034817 0.568181818181818 12.5 12 5 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.06266517623854e-07 1.73678848863163e-06 2.14584240034817 0.568181818181818 12.5 12 5 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.99473621205093e-06 1.44821919885127e-05 2.14352257072618 0.567567567567568 12.5 12 5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.95945159018603e-05 0.000109775575308453 2.14012015394724 0.566666666666667 12.5 12 5 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000197194669531139 0.000860760781419665 2.1346467008681 0.565217391304348 12.5 12 5 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 5.13784008575251e-18 4.30067437766225e-16 2.1319982558298 0.564516129032258 12.5 12 5 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 5.13784008575251e-18 4.30067437766225e-16 2.1319982558298 0.564516129032258 12.5 12 5 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 5.13784008575251e-18 4.30067437766225e-16 2.1319982558298 0.564516129032258 12.5 12 5 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00206903915211991 0.0066311772825825 2.12438397634469 0.5625 12.5 12 5 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00206903915211991 0.0066311772825825 2.12438397634469 0.5625 12.5 12 5 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00206903915211991 0.0066311772825825 2.12438397634469 0.5625 12.5 12 5 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.98282844595525e-12 1.50863082523283e-10 2.12438397634469 0.5625 12.5 12 5 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 8.61971882544943e-07 6.63019453438624e-06 2.11862683819742 0.560975609756098 12.5 12 5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 8.61971882544943e-07 6.63019453438624e-06 2.11862683819742 0.560975609756098 12.5 12 5 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.000127867641451463 0.00060051370886281 2.11494226978316 0.56 12.5 12 5 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000127867641451463 0.00060051370886281 2.11494226978316 0.56 12.5 12 5 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000127867641451463 0.00060051370886281 2.11494226978316 0.56 12.5 12 5 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000127867641451463 0.00060051370886281 2.11494226978316 0.56 12.5 12 5 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 3.89789177788274e-08 4.33335937494308e-07 2.10622684834175 0.557692307692308 12.5 12 5 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 3.89789177788274e-08 4.33335937494308e-07 2.10622684834175 0.557692307692308 12.5 12 5 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 3.24003406404732e-15 1.92107019714139e-13 2.09815701367377 0.555555555555556 12.5 12 5 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 5.47562607504476e-06 3.4630292910172e-05 2.09815701367377 0.555555555555556 12.5 12 5 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00132102666558352 0.00454063030223513 2.09815701367377 0.555555555555556 12.5 12 5 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0237031100064566 0.0556592830679665 2.09815701367377 0.555555555555556 12.5 12 5 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.43910829244564e-07 2.01793668613381e-06 2.08922868595601 0.553191489361702 12.5 12 5 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 9.39671438224799e-16 5.81370633301691e-14 2.08711408202285 0.552631578947368 12.5 12 5 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 5.38040763065861e-05 0.000268715367688088 2.08368696530361 0.551724137931034 12.5 12 5 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 5.38040763065861e-05 0.000268715367688088 2.08368696530361 0.551724137931034 12.5 12 5 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.33783861919431e-06 1.63075703682034e-05 2.07717544353703 0.55 12.5 12 5 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 2.33783861919431e-06 1.63075703682034e-05 2.07717544353703 0.55 12.5 12 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000845187957943683 0.00301429189010993 2.07717544353703 0.55 12.5 12 5 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000845187957943683 0.00301429189010993 2.07717544353703 0.55 12.5 12 5 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000845187957943683 0.00301429189010993 2.07717544353703 0.55 12.5 12 5 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000845187957943683 0.00301429189010993 2.07717544353703 0.55 12.5 12 5 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 1.52744237359165e-06 1.15002671831795e-05 2.06818334204986 0.547619047619048 12.5 12 5 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 6.85868426578552e-12 1.95198154204256e-10 2.06400096926513 0.546511627906977 12.5 12 5 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.12713650221046e-13 9.45911013326715e-12 2.06000870433425 0.545454545454545 12.5 12 5 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000541771368855809 0.002116942049343 2.06000870433425 0.545454545454545 12.5 12 5 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000541771368855809 0.002116942049343 2.06000870433425 0.545454545454545 12.5 12 5 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0146041951183081 0.0362051736121123 2.06000870433425 0.545454545454545 12.5 12 5 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0146041951183081 0.0362051736121123 2.06000870433425 0.545454545454545 12.5 12 5 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0146041951183081 0.0362051736121123 2.06000870433425 0.545454545454545 12.5 12 5 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0146041951183081 0.0362051736121123 2.06000870433425 0.545454545454545 12.5 12 5 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0146041951183081 0.0362051736121123 2.06000870433425 0.545454545454545 12.5 12 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0146041951183081 0.0362051736121123 2.06000870433425 0.545454545454545 12.5 12 5 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0146041951183081 0.0362051736121123 2.06000870433425 0.545454545454545 12.5 12 5 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0146041951183081 0.0362051736121123 2.06000870433425 0.545454545454545 12.5 12 5 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.97703647500249e-12 1.05908072598214e-10 2.05619387340029 0.544444444444444 12.5 12 5 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.12200990991045e-26 3.35513344644731e-24 2.05019913907551 0.542857142857143 12.5 12 5 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000347874382274592 0.00143902687783937 2.04570308833193 0.541666666666667 12.5 12 5 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.000347874382274592 0.00143902687783937 2.04570308833193 0.541666666666667 12.5 12 5 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00908308490289576 0.024224893259629 2.03359833632996 0.538461538461538 12.5 12 5 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00908308490289576 0.024224893259629 2.03359833632996 0.538461538461538 12.5 12 5 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00908308490289576 0.024224893259629 2.03359833632996 0.538461538461538 12.5 12 5 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.37852648743593e-12 1.10186121467297e-10 2.03047452936171 0.537634408602151 12.5 12 5 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.2207142305562e-12 8.31599039495126e-11 2.02748225110792 0.536842105263158 12.5 12 5 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 4.53849157134052e-14 2.48395134846829e-12 2.02567522592868 0.536363636363636 12.5 12 5 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.34751400539295e-09 3.71168047741574e-08 2.02517763928512 0.536231884057971 12.5 12 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.03364115484235e-11 4.90486671752655e-10 2.01709185632728 0.534090909090909 12.5 12 5 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.74424849975874e-16 1.24103280757835e-14 2.01612380712412 0.533834586466165 12.5 12 5 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.60947759674867e-10 1.1611464963177e-08 2.01423073312682 0.533333333333333 12.5 12 5 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.60947759674867e-10 1.1611464963177e-08 2.01423073312682 0.533333333333333 12.5 12 5 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.60947759674867e-10 1.1611464963177e-08 2.01423073312682 0.533333333333333 12.5 12 5 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.60947759674867e-10 1.1611464963177e-08 2.01423073312682 0.533333333333333 12.5 12 5 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.60947759674867e-10 1.1611464963177e-08 2.01423073312682 0.533333333333333 12.5 12 5 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.7137397960266e-06 1.28350091039255e-05 2.01423073312682 0.533333333333333 12.5 12 5 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 9.29007167691302e-05 0.0004527319176797 2.01423073312682 0.533333333333333 12.5 12 5 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00568963890835046 0.016159630353075 2.01423073312682 0.533333333333333 12.5 12 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00568963890835046 0.016159630353075 2.01423073312682 0.533333333333333 12.5 12 5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00568963890835046 0.016159630353075 2.01423073312682 0.533333333333333 12.5 12 5 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00568963890835046 0.016159630353075 2.01423073312682 0.533333333333333 12.5 12 5 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00568963890835046 0.016159630353075 2.01423073312682 0.533333333333333 12.5 12 5 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00568963890835046 0.016159630353075 2.01423073312682 0.533333333333333 12.5 12 5 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00568963890835046 0.016159630353075 2.01423073312682 0.533333333333333 12.5 12 5 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00568963890835046 0.016159630353075 2.01423073312682 0.533333333333333 12.5 12 5 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.83927149186288e-10 5.53463470263133e-09 2.00785658523718 0.531645569620253 12.5 12 5 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.83927149186288e-10 5.53463470263133e-09 2.00785658523718 0.531645569620253 12.5 12 5 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 7.99453786906633e-11 1.72367081631536e-09 1.9994202130303 0.529411764705882 12.5 12 5 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 7.99453786906633e-11 1.72367081631536e-09 1.9994202130303 0.529411764705882 12.5 12 5 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 7.99453786906633e-11 1.72367081631536e-09 1.9994202130303 0.529411764705882 12.5 12 5 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00358399342077035 0.010851111995226 1.9994202130303 0.529411764705882 12.5 12 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.24001066421906e-11 1.18357701193392e-09 1.99686667508262 0.528735632183908 12.5 12 5 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.05152586022609e-05 6.25671905004188e-05 1.98275837792171 0.525 12.5 12 5 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0014403628684908 0.00489173356053082 1.97826232717813 0.523809523809524 12.5 12 5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.42365091233728e-06 2.88754827901649e-05 1.97417500832032 0.522727272727273 12.5 12 5 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.55341032824376e-08 1.85756545974022e-07 1.97289390837981 0.522388059701492 12.5 12 5 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.87194685866979e-06 1.93686273928299e-05 1.97044310849363 0.521739130434783 12.5 12 5 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.000917673222664539 0.00324838058669562 1.97044310849363 0.521739130434783 12.5 12 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000917673222664539 0.00324838058669562 1.97044310849363 0.521739130434783 12.5 12 5 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.01444357624917e-08 1.23380616154066e-07 1.97044310849363 0.521739130434783 12.5 12 5 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.86561000954228e-06 1.38268908519722e-05 1.96702220031916 0.520833333333333 12.5 12 5 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000586215018166316 0.00223641815241466 1.96387496479865 0.52 12.5 12 5 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000586215018166316 0.00223641815241466 1.96387496479865 0.52 12.5 12 5 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000586215018166316 0.00223641815241466 1.96387496479865 0.52 12.5 12 5 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000586215018166316 0.00223641815241466 1.96387496479865 0.52 12.5 12 5 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.95861973532668e-12 1.05908072598214e-10 1.96096982431818 0.519230769230769 12.5 12 5 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 7.89729132191224e-10 1.35395729531098e-08 1.95827987942885 0.518518518518518 12.5 12 5 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 7.89729132191224e-10 1.35395729531098e-08 1.95827987942885 0.518518518518518 12.5 12 5 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000375333989036842 0.00152165318062515 1.95827987942885 0.518518518518518 12.5 12 5 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000375333989036842 0.00152165318062515 1.95827987942885 0.518518518518518 12.5 12 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000375333989036842 0.00152165318062515 1.95827987942885 0.518518518518518 12.5 12 5 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000375333989036842 0.00152165318062515 1.95827987942885 0.518518518518518 12.5 12 5 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000154746632714128 0.000690296107687161 1.94925554818724 0.516129032258065 12.5 12 5 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 9.96023296086572e-05 0.000482088826643263 1.94556377631568 0.515151515151515 12.5 12 5 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 3.17575512945936e-12 1.07597608314778e-10 1.94128546124956 0.514018691588785 12.5 12 5 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.07886342016744e-12 7.99519634296828e-11 1.94031400897538 0.513761467889908 12.5 12 5 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.3609181697055e-12 5.5331044442598e-11 1.93937756399035 0.513513513513513 12.5 12 5 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.73072063415019e-05 9.89082515018362e-05 1.9343984174846 0.51219512195122 12.5 12 5 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.73072063415019e-05 9.89082515018362e-05 1.9343984174846 0.51219512195122 12.5 12 5 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.73072063415019e-05 9.89082515018362e-05 1.9343984174846 0.51219512195122 12.5 12 5 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.73072063415019e-05 9.89082515018362e-05 1.9343984174846 0.51219512195122 12.5 12 5 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 7.25673980666203e-06 4.45100894175865e-05 1.93030445257987 0.511111111111111 12.5 12 5 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.30300200930883e-11 9.87608364394591e-10 1.92687889010856 0.510204081632653 12.5 12 5 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.9810924913535e-06 1.44568954625437e-05 1.92536761254769 0.509803921568627 12.5 12 5 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 8.36225029709109e-07 6.50244927473258e-06 1.92267479071196 0.509090909090909 12.5 12 5 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.14389468298094e-08 4.53597087221683e-07 1.91570857770214 0.507246376811594 12.5 12 5 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.14389468298094e-08 4.53597087221683e-07 1.91570857770214 0.507246376811594 12.5 12 5 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.89290090556279e-09 7.03292726122812e-08 1.91224436689255 0.506329113924051 12.5 12 5 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.36169953092448e-09 2.30678384822088e-08 1.91055709245117 0.505882352941176 12.5 12 5 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.62120630116714e-10 3.249262769804e-09 1.90821858927804 0.505263157894737 12.5 12 5 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.62120630116714e-10 3.249262769804e-09 1.90821858927804 0.505263157894737 12.5 12 5 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.82281921823043e-13 8.3764305680333e-12 1.90321014153715 0.503937007874016 12.5 12 5 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.41885127460375e-41 8.7353088937684e-39 1.89720676447685 0.502347417840376 12.5 12 5 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00931023866458103 0.0244888532711623 1.88834131230639 0.5 12.5 12 5 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00931023866458103 0.0244888532711623 1.88834131230639 0.5 12.5 12 5 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.83462194299316e-08 2.15757605361923e-07 1.88834131230639 0.5 12.5 12 5 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.83462194299316e-08 2.15757605361923e-07 1.88834131230639 0.5 12.5 12 5 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000948712235480255 0.00333337657058865 1.88834131230639 0.5 12.5 12 5 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000948712235480255 0.00333337657058865 1.88834131230639 0.5 12.5 12 5 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.10412222054552e-10 2.3105381174063e-09 1.88834131230639 0.5 12.5 12 5 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.10412222054552e-10 2.3105381174063e-09 1.88834131230639 0.5 12.5 12 5 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.32684228198473e-09 5.09042641641319e-08 1.88834131230639 0.5 12.5 12 5 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.32684228198473e-09 5.09042641641319e-08 1.88834131230639 0.5 12.5 12 5 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 6.62009424721466e-08 6.92676037778416e-07 1.88834131230639 0.5 12.5 12 5 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 4.89121159877223e-06 3.149409097309e-05 1.88834131230639 0.5 12.5 12 5 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000160449100301761 0.000709421896125861 1.88834131230639 0.5 12.5 12 5 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000160449100301761 0.000709421896125861 1.88834131230639 0.5 12.5 12 5 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000606594059468712 0.00227752861906062 1.88834131230639 0.5 12.5 12 5 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000606594059468712 0.00227752861906062 1.88834131230639 0.5 12.5 12 5 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00148747206305448 0.0049921527021852 1.88834131230639 0.5 12.5 12 5 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00148747206305448 0.0049921527021852 1.88834131230639 0.5 12.5 12 5 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00148747206305448 0.0049921527021852 1.88834131230639 0.5 12.5 12 5 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00148747206305448 0.0049921527021852 1.88834131230639 0.5 12.5 12 5 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0023389543681258 0.00737989371583818 1.88834131230639 0.5 12.5 12 5 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0023389543681258 0.00737989371583818 1.88834131230639 0.5 12.5 12 5 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0023389543681258 0.00737989371583818 1.88834131230639 0.5 12.5 12 5 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0149183665294186 0.0368556173113934 1.88834131230639 0.5 12.5 12 5 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0149183665294186 0.0368556173113934 1.88834131230639 0.5 12.5 12 5 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0240987128477738 0.0561251528353227 1.88834131230639 0.5 12.5 12 5 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0240987128477738 0.0561251528353227 1.88834131230639 0.5 12.5 12 5 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.06056695517425e-06 1.47346069206681e-05 1.88834131230639 0.5 12.5 12 5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000103324723537627 0.000496269710239844 1.88834131230639 0.5 12.5 12 5 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00369047985969067 0.0111261712719064 1.88834131230639 0.5 12.5 12 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00584696017595718 0.0163462167591102 1.88834131230639 0.5 12.5 12 5 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0393512134302226 0.0852310147811366 1.88834131230639 0.5 12.5 12 5 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 3.42578355948686e-09 5.13146316331558e-08 1.86663623975115 0.494252873563218 12.5 12 5 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 3.42578355948686e-09 5.13146316331558e-08 1.86663623975115 0.494252873563218 12.5 12 5 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.88657598828096e-08 2.20048986174083e-07 1.86443825772024 0.493670886075949 12.5 12 5 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 6.79898619899345e-08 7.06201267238517e-07 1.86247362309672 0.493150684931507 12.5 12 5 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.86953952350302e-17 1.40018670628674e-15 1.85738489735055 0.491803278688525 12.5 12 5 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 8.90573268293102e-07 6.81336430527465e-06 1.85738489735055 0.491803278688525 12.5 12 5 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.34681393177922e-27 9.51064528115228e-25 1.85611705783017 0.491467576791809 12.5 12 5 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.46539088890312e-20 1.60403941146857e-18 1.84600182099907 0.488789237668161 12.5 12 5 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 4.36363655429848e-05 0.000229131174050433 1.84442639806671 0.488372093023256 12.5 12 5 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 4.36363655429848e-05 0.000229131174050433 1.84442639806671 0.488372093023256 12.5 12 5 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 5.06804725720253e-46 3.6059156234996e-43 1.83808127737809 0.486692015209125 12.5 12 5 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.05750317135488e-07 1.05232658240419e-06 1.83730506062244 0.486486486486487 12.5 12 5 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.05750317135488e-07 1.05232658240419e-06 1.83730506062244 0.486486486486487 12.5 12 5 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.62142906627311e-07 1.38416341672296e-06 1.83588738696455 0.486111111111111 12.5 12 5 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 2.48678188938967e-07 2.04548591248642e-06 1.83438870338335 0.485714285714286 12.5 12 5 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000251354187686723 0.00108059519358975 1.83438870338335 0.485714285714286 12.5 12 5 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000390620944562085 0.00157020792121991 1.83111884829711 0.484848484848485 12.5 12 5 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000390620944562085 0.00157020792121991 1.83111884829711 0.484848484848485 12.5 12 5 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 6.27465466539388e-23 8.9288335888555e-21 1.82322609464065 0.482758620689655 12.5 12 5 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 3.259721336385e-06 2.14749234336845e-05 1.82322609464065 0.482758620689655 12.5 12 5 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000948009681976486 0.00333337657058865 1.82322609464065 0.482758620689655 12.5 12 5 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 7.71170383344799e-06 4.66968278936021e-05 1.81840274518393 0.481481481481481 12.5 12 5 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00148113489289199 0.0049921527021852 1.81840274518393 0.481481481481481 12.5 12 5 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 4.52359012718292e-08 4.83990131652729e-07 1.81840274518393 0.481481481481481 12.5 12 5 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.62442228104522e-07 1.38416341672296e-06 1.81280765981414 0.48 12.5 12 5 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00231940164295124 0.00736720655785628 1.81280765981414 0.48 12.5 12 5 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.19388623619768e-11 5.20316685684883e-10 1.81157947034272 0.479674796747967 12.5 12 5 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00364179541813197 0.0110027067515962 1.80623951611916 0.478260869565217 12.5 12 5 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.000103578428630523 0.000496269710239844 1.79842029743466 0.476190476190476 12.5 12 5 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000103578428630523 0.000496269710239844 1.79842029743466 0.476190476190476 12.5 12 5 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00573604076078147 0.016159630353075 1.79842029743466 0.476190476190476 12.5 12 5 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00573604076078147 0.016159630353075 1.79842029743466 0.476190476190476 12.5 12 5 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.54851119669601e-18 4.38640635161024e-16 1.79842029743466 0.476190476190476 12.5 12 5 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.10848966881969e-06 1.49272676553752e-05 1.79842029743466 0.476190476190476 12.5 12 5 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 2.10848966881969e-06 1.49272676553752e-05 1.79842029743466 0.476190476190476 12.5 12 5 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 6.88656223452723e-08 7.10114352154511e-07 1.79622710194998 0.475609756097561 12.5 12 5 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.2357034829186e-06 2.14158421218287e-05 1.79547206743887 0.475409836065574 12.5 12 5 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.2357034829186e-06 2.14158421218287e-05 1.79547206743887 0.475409836065574 12.5 12 5 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 6.39201432629248e-10 1.1611464963177e-08 1.78534087708968 0.472727272727273 12.5 12 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.17197575473725e-05 6.86305143617742e-05 1.78534087708968 0.472727272727273 12.5 12 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.17197575473725e-05 6.86305143617742e-05 1.78534087708968 0.472727272727273 12.5 12 5 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 5.77485631239565e-07 4.51517611677967e-06 1.7834334616227 0.472222222222222 12.5 12 5 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000383801602978017 0.00155156159385716 1.7834334616227 0.472222222222222 12.5 12 5 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.80132822366951e-05 0.000101315812738408 1.78145406821358 0.471698113207547 12.5 12 5 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.80132822366951e-05 0.000101315812738408 1.78145406821358 0.471698113207547 12.5 12 5 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.26732023859938e-09 3.62516483092913e-08 1.77939854428872 0.471153846153846 12.5 12 5 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000595218139460148 0.002252647373542 1.77726241158249 0.470588235294118 12.5 12 5 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000595218139460148 0.002252647373542 1.77726241158249 0.470588235294118 12.5 12 5 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000595218139460148 0.002252647373542 1.77726241158249 0.470588235294118 12.5 12 5 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0144002344368572 0.0362041229746427 1.77726241158249 0.470588235294118 12.5 12 5 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0144002344368572 0.0362041229746427 1.77726241158249 0.470588235294118 12.5 12 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0144002344368572 0.0362041229746427 1.77726241158249 0.470588235294118 12.5 12 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0144002344368572 0.0362041229746427 1.77726241158249 0.470588235294118 12.5 12 5 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.42082662997082e-07 2.01452414880028e-06 1.76882603937561 0.468354430379747 12.5 12 5 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 4.86611901202003e-06 3.14749425186568e-05 1.76651284054469 0.467741935483871 12.5 12 5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 7.45794219370142e-06 4.55478615520906e-05 1.76245189148597 0.466666666666667 12.5 12 5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00143742096901073 0.00489173356053082 1.76245189148597 0.466666666666667 12.5 12 5 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0229935031978532 0.0548069598836602 1.76245189148597 0.466666666666667 12.5 12 5 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0229935031978532 0.0548069598836602 1.76245189148597 0.466666666666667 12.5 12 5 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0229935031978532 0.0548069598836602 1.76245189148597 0.466666666666667 12.5 12 5 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.14333083072026e-05 6.75087042371338e-05 1.75811087697492 0.46551724137931 12.5 12 5 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.32062536541637e-06 9.9960100797207e-06 1.7553595297496 0.464788732394366 12.5 12 5 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.75326720844074e-05 9.93983760004454e-05 1.75345978999879 0.464285714285714 12.5 12 5 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.98972821178686e-10 1.15180854667199e-08 1.74552558280423 0.46218487394958 12.5 12 5 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00349427827792639 0.0106020426215123 1.74308428828282 0.461538461538462 12.5 12 5 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00349427827792639 0.0106020426215123 1.74308428828282 0.461538461538462 12.5 12 5 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0369692510862408 0.0816882675399389 1.74308428828282 0.461538461538462 12.5 12 5 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0369692510862408 0.0816882675399389 1.74308428828282 0.461538461538462 12.5 12 5 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0369692510862408 0.0816882675399389 1.74308428828282 0.461538461538462 12.5 12 5 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0369692510862408 0.0816882675399389 1.74308428828282 0.461538461538462 12.5 12 5 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0369692510862408 0.0816882675399389 1.74308428828282 0.461538461538462 12.5 12 5 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000572363292357584 0.0022072438076554 1.73523255725452 0.459459459459459 12.5 12 5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000572363292357584 0.0022072438076554 1.73523255725452 0.459459459459459 12.5 12 5 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00546468441088983 0.0158375680584445 1.73097953628086 0.458333333333333 12.5 12 5 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.68890210338771e-05 9.80941915559471e-05 1.72831238753466 0.457627118644068 12.5 12 5 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000149395609194441 0.000668521861269464 1.72413771993192 0.456521739130435 12.5 12 5 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.000149395609194441 0.000668521861269464 1.72413771993192 0.456521739130435 12.5 12 5 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.87373677617615e-16 1.94729877738031e-14 1.71667392027854 0.454545454545455 12.5 12 5 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.95391163794808e-05 0.000209160455791826 1.71667392027854 0.454545454545455 12.5 12 5 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.95391163794808e-05 0.000209160455791826 1.71667392027854 0.454545454545455 12.5 12 5 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.95391163794808e-05 0.000209160455791826 1.71667392027854 0.454545454545455 12.5 12 5 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.95391163794808e-05 0.000209160455791826 1.71667392027854 0.454545454545455 12.5 12 5 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00856694608799451 0.0231323800440535 1.71667392027854 0.454545454545455 12.5 12 5 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0599737286901513 0.122442777512317 1.71667392027854 0.454545454545455 12.5 12 5 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0599737286901513 0.122442777512317 1.71667392027854 0.454545454545455 12.5 12 5 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0599737286901513 0.122442777512317 1.71667392027854 0.454545454545455 12.5 12 5 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0599737286901513 0.122442777512317 1.71667392027854 0.454545454545455 12.5 12 5 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0599737286901513 0.122442777512317 1.71667392027854 0.454545454545455 12.5 12 5 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0599737286901513 0.122442777512317 1.71667392027854 0.454545454545455 12.5 12 5 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0599737286901513 0.122442777512317 1.71667392027854 0.454545454545455 12.5 12 5 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00136903261837192 0.00468301301909435 1.71667392027854 0.454545454545455 12.5 12 5 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 8.95216492779215e-13 3.74674432124948e-11 1.71061507114814 0.452941176470588 12.5 12 5 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.8449392493908e-06 1.92778502470624e-05 1.70726748783866 0.452054794520548 12.5 12 5 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.74379232976215e-13 1.61436863189441e-11 1.7069751975651 0.451977401129944 12.5 12 5 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00212047569812676 0.00678075712007726 1.70559860466384 0.451612903225806 12.5 12 5 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.46053582667482e-05 0.00013730754828856 1.69950718107575 0.45 12.5 12 5 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000542767378079094 0.002116942049343 1.69950718107575 0.45 12.5 12 5 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0134681052354952 0.0341624131017999 1.69950718107575 0.45 12.5 12 5 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0134681052354952 0.0341624131017999 1.69950718107575 0.45 12.5 12 5 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0134681052354952 0.0341624131017999 1.69950718107575 0.45 12.5 12 5 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.95938406252249e-12 7.74500978047084e-11 1.6983898193525 0.449704142011834 12.5 12 5 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.7544552965421e-05 0.000201607165546393 1.69299565930918 0.448275862068966 12.5 12 5 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.7544552965421e-05 0.000201607165546393 1.69299565930918 0.448275862068966 12.5 12 5 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 6.76555303883512e-12 1.95198154204256e-10 1.69139773985726 0.447852760736196 12.5 12 5 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.0038048187129e-05 6.00174057574983e-05 1.69105192146841 0.447761194029851 12.5 12 5 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000835129776419868 0.00300858144771005 1.68956854258993 0.447368421052632 12.5 12 5 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000835129776419868 0.00300858144771005 1.68956854258993 0.447368421052632 12.5 12 5 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000835129776419868 0.00300858144771005 1.68956854258993 0.447368421052632 12.5 12 5 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.72862488755079e-05 0.000285029133391076 1.68601902884499 0.446428571428571 12.5 12 5 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.52782910827783e-05 8.91024926671863e-05 1.6849814786734 0.446153846153846 12.5 12 5 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.23721229650095e-06 3.8978584708403e-05 1.67852561093902 0.444444444444444 12.5 12 5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.23721229650095e-06 3.8978584708403e-05 1.67852561093902 0.444444444444444 12.5 12 5 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 8.74042209178613e-05 0.000428883470227989 1.67852561093902 0.444444444444444 12.5 12 5 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00510479298595389 0.0148692656939115 1.67852561093902 0.444444444444444 12.5 12 5 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00510479298595389 0.0148692656939115 1.67852561093902 0.444444444444444 12.5 12 5 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0212428538455772 0.0509756846918319 1.67852561093902 0.444444444444444 12.5 12 5 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0212428538455772 0.0509756846918319 1.67852561093902 0.444444444444444 12.5 12 5 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0212428538455772 0.0509756846918319 1.67852561093902 0.444444444444444 12.5 12 5 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00197993878593385 0.00642084175741124 1.66618351085858 0.441176470588235 12.5 12 5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00197993878593385 0.00642084175741124 1.66618351085858 0.441176470588235 12.5 12 5 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 5.38186084266374e-05 0.000268715367688088 1.66430081762597 0.440677966101695 12.5 12 5 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 5.38186084266374e-05 0.000268715367688088 1.66430081762597 0.440677966101695 12.5 12 5 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.26816215649456e-33 3.00765791448627e-31 1.6620232524045 0.440074906367041 12.5 12 5 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00793597801427014 0.0215102794558217 1.66174035482963 0.44 12.5 12 5 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 7.3061379906445e-08 7.47959306524254e-07 1.65891666688599 0.439252336448598 12.5 12 5 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000779622022218773 0.00286667219022562 1.65805578641537 0.439024390243902 12.5 12 5 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 7.77295275849174e-21 1.00553743412125e-18 1.656642991778 0.438650306748466 12.5 12 5 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.31154381975564e-05 0.000179859803645507 1.65229864826809 0.4375 12.5 12 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0336360422792871 0.0750220817608551 1.65229864826809 0.4375 12.5 12 5 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0336360422792871 0.0750220817608551 1.65229864826809 0.4375 12.5 12 5 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0336360422792871 0.0750220817608551 1.65229864826809 0.4375 12.5 12 5 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0336360422792871 0.0750220817608551 1.65229864826809 0.4375 12.5 12 5 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0336360422792871 0.0750220817608551 1.65229864826809 0.4375 12.5 12 5 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.60622445470173e-53 5.13165739904057e-50 1.64482218379629 0.43552036199095 12.5 12 5 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 5.02292704333867e-05 0.000258794572909341 1.64468436878299 0.435483870967742 12.5 12 5 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.24324963125269e-06 1.58026941845177e-05 1.6439677307138 0.435294117647059 12.5 12 5 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0123555235263503 0.0320837773321104 1.64203592374469 0.434782608695652 12.5 12 5 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0123555235263503 0.0320837773321104 1.64203592374469 0.434782608695652 12.5 12 5 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.77623313084e-07 3.07061699724875e-06 1.64037730159949 0.434343434343434 12.5 12 5 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00470324929298573 0.0138853189707857 1.63656247066554 0.433333333333333 12.5 12 5 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.19689640095958e-12 1.29830077794902e-10 1.63588926520661 0.433155080213904 12.5 12 5 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 3.08204361866109e-05 0.00016803632449635 1.63468352408613 0.432835820895522 12.5 12 5 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 3.08204361866109e-05 0.00016803632449635 1.63468352408613 0.432835820895522 12.5 12 5 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00182897743932605 0.00601070414817777 1.63316005388661 0.432432432432432 12.5 12 5 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000287474593364249 0.00122112342196217 1.62915721061728 0.431372549019608 12.5 12 5 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.146251779552e-06 2.10193252690258e-05 1.62485182686829 0.430232558139535 12.5 12 5 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0192671535915306 0.0469471910286782 1.61857826769119 0.428571428571429 12.5 12 5 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0535074145038573 0.110670132033414 1.61857826769119 0.428571428571429 12.5 12 5 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 5.12856602551843e-08 5.40588848467609e-07 1.60973357770381 0.426229508196721 12.5 12 5 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00167552429579665 0.00558377300449328 1.60509011546043 0.425 12.5 12 5 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00040050142375767 0.00160539021410469 1.59782726425926 0.423076923076923 12.5 12 5 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.0111932244875889 0.0292793353783804 1.59782726425926 0.423076923076923 12.5 12 5 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0111932244875889 0.0292793353783804 1.59782726425926 0.423076923076923 12.5 12 5 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0111932244875889 0.0292793353783804 1.59782726425926 0.423076923076923 12.5 12 5 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 4.89147758359217e-15 2.78422904058066e-13 1.59782726425926 0.423076923076923 12.5 12 5 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 7.78032184622778e-16 5.03245363053733e-14 1.59520529631659 0.422382671480144 12.5 12 5 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 9.77168800334038e-05 0.000474577202346531 1.59328798225852 0.421875 12.5 12 5 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00255177573962146 0.00801574106602093 1.5901821577317 0.421052631578947 12.5 12 5 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0300971665940819 0.0692248650925675 1.5901821577317 0.421052631578947 12.5 12 5 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0300971665940819 0.0692248650925675 1.5901821577317 0.421052631578947 12.5 12 5 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0300971665940819 0.0692248650925675 1.5901821577317 0.421052631578947 12.5 12 5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0006055218802975 0.00227752861906062 1.58620670233737 0.42 12.5 12 5 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00656858577816164 0.0180794923836055 1.58377013290214 0.419354838709677 12.5 12 5 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00152489220987597 0.00510569791683178 1.58093691262861 0.418604651162791 12.5 12 5 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.27096944811792e-08 2.58527161973744e-07 1.57588195847152 0.41726618705036 12.5 12 5 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.57157807043101e-09 5.2941204106493e-08 1.57361776025533 0.416666666666667 12.5 12 5 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0172775514659649 0.0423166191670707 1.57361776025533 0.416666666666667 12.5 12 5 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0172775514659649 0.0423166191670707 1.57361776025533 0.416666666666667 12.5 12 5 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0855987400061352 0.162626177608452 1.57361776025533 0.416666666666667 12.5 12 5 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0855987400061352 0.162626177608452 1.57361776025533 0.416666666666667 12.5 12 5 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0855987400061352 0.162626177608452 1.57361776025533 0.416666666666667 12.5 12 5 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0855987400061352 0.162626177608452 1.57361776025533 0.416666666666667 12.5 12 5 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0855987400061352 0.162626177608452 1.57361776025533 0.416666666666667 12.5 12 5 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0855987400061352 0.162626177608452 1.57361776025533 0.416666666666667 12.5 12 5 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00388396297449486 0.0116032602800132 1.57361776025533 0.416666666666667 12.5 12 5 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.00388396297449486 0.0116032602800132 1.57361776025533 0.416666666666667 12.5 12 5 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00138050670338975 0.00471093774322211 1.55993412755745 0.41304347826087 12.5 12 5 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.82480216169383e-13 8.3764305680333e-12 1.55863092444337 0.412698412698413 12.5 12 5 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.82480216169383e-13 8.3764305680333e-12 1.55863092444337 0.412698412698413 12.5 12 5 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.82480216169383e-13 8.3764305680333e-12 1.55863092444337 0.412698412698413 12.5 12 5 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.000200881273159104 0.000874171411943133 1.55863092444337 0.412698412698413 12.5 12 5 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0471011077689881 0.0988567497865341 1.55510461013468 0.411764705882353 12.5 12 5 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0471011077689881 0.0988567497865341 1.55510461013468 0.411764705882353 12.5 12 5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0471011077689881 0.0988567497865341 1.55510461013468 0.411764705882353 12.5 12 5 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0471011077689881 0.0988567497865341 1.55510461013468 0.411764705882353 12.5 12 5 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0471011077689881 0.0988567497865341 1.55510461013468 0.411764705882353 12.5 12 5 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0471011077689881 0.0988567497865341 1.55510461013468 0.411764705882353 12.5 12 5 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0471011077689881 0.0988567497865341 1.55510461013468 0.411764705882353 12.5 12 5 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0471011077689881 0.0988567497865341 1.55510461013468 0.411764705882353 12.5 12 5 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 6.56825917631913e-09 9.16336549794325e-08 1.5536985481002 0.411392405063291 12.5 12 5 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.73484799475237e-05 0.000150840647152427 1.54707481008235 0.409638554216867 12.5 12 5 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.49425487637606e-07 1.38416341672296e-06 1.54500652825068 0.409090909090909 12.5 12 5 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0266749895555171 0.0618216777483728 1.54500652825068 0.409090909090909 12.5 12 5 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 5.44259554613888e-09 7.74481346215562e-08 1.54291302346986 0.408536585365854 12.5 12 5 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00124444932946191 0.00428777577681428 1.54150311208685 0.408163265306122 12.5 12 5 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.12751800240116e-08 2.44149848178778e-07 1.54048896530258 0.407894736842105 12.5 12 5 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.93129607643639e-08 2.23433684290161e-07 1.53503874419745 0.406451612903226 12.5 12 5 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000271467436876686 0.00116005454256914 1.53427731624894 0.40625 12.5 12 5 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00897546820165279 0.02414383979386 1.53427731624894 0.40625 12.5 12 5 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00897546820165279 0.02414383979386 1.53427731624894 0.40625 12.5 12 5 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.1870446825536e-08 1.43149540955405e-07 1.53427731624894 0.40625 12.5 12 5 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.00528508947574635 0.015348331273443 1.5310875505187 0.405405405405405 12.5 12 5 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.36866020690052e-07 3.53216106501105e-06 1.52238369364236 0.403100775193798 12.5 12 5 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.80606729809088e-06 1.91054247137958e-05 1.51741712596049 0.401785714285714 12.5 12 5 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000363094428695754 0.00149330454345104 1.51067304984511 0.4 12.5 12 5 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0411832074998064 0.0886591592620643 1.51067304984511 0.4 12.5 12 5 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0738500220411935 0.142977661720569 1.51067304984511 0.4 12.5 12 5 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0738500220411935 0.142977661720569 1.51067304984511 0.4 12.5 12 5 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0738500220411935 0.142977661720569 1.51067304984511 0.4 12.5 12 5 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0738500220411935 0.142977661720569 1.51067304984511 0.4 12.5 12 5 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0738500220411935 0.142977661720569 1.51067304984511 0.4 12.5 12 5 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.04735279832655e-06 1.47140557172661e-05 1.49818814860672 0.396694214876033 12.5 12 5 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.04735279832655e-06 1.47140557172661e-05 1.49818814860672 0.396694214876033 12.5 12 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00249168213122321 0.0078443886564837 1.49493687224256 0.395833333333333 12.5 12 5 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.22014765006334e-33 6.54610015148591e-31 1.49423166581991 0.395646606914213 12.5 12 5 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 6.10115922130644e-10 1.15759327625588e-08 1.49268884687077 0.395238095238095 12.5 12 5 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000176007419438469 0.000770641716495202 1.49079577287347 0.394736842105263 12.5 12 5 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.000290624808430888 0.00123083066189629 1.48939596463603 0.394366197183099 12.5 12 5 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0120209854728358 0.0313294181828668 1.4877840642414 0.393939393939394 12.5 12 5 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0120209854728358 0.0313294181828668 1.4877840642414 0.393939393939394 12.5 12 5 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.01093480096317e-08 1.23380616154066e-07 1.48590791788044 0.39344262295082 12.5 12 5 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.1166919967748e-12 1.07597608314778e-10 1.48568029718224 0.393382352941176 12.5 12 5 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0206363327590991 0.0497720364681323 1.48369674538359 0.392857142857143 12.5 12 5 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 5.55692555088093e-07 4.39018888412935e-06 1.48369674538359 0.392857142857143 12.5 12 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00221378546616553 0.00704746469430324 1.48105200965207 0.392156862745098 12.5 12 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00221378546616553 0.00704746469430324 1.48105200965207 0.392156862745098 12.5 12 5 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0037093346816417 0.0111593726257424 1.47783233137022 0.391304347826087 12.5 12 5 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00624601580810955 0.0173595322166795 1.47382736570255 0.390243902439024 12.5 12 5 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00117872387170409 0.00407117492581291 1.4722661078999 0.389830508474576 12.5 12 5 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.93117042356348e-06 1.41652346017053e-05 1.47031155614696 0.389312977099237 12.5 12 5 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.93117042356348e-06 1.41652346017053e-05 1.47031155614696 0.389312977099237 12.5 12 5 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0635563602657041 0.128068053840047 1.46870990957164 0.388888888888889 12.5 12 5 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.00328159623900537 0.0100208400173919 1.46442795648251 0.387755102040816 12.5 12 5 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 5.67197474410584e-39 1.61424401217252e-36 1.46303921494009 0.387387387387387 12.5 12 5 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0180744342942949 0.0441923024068414 1.46194166114043 0.387096774193548 12.5 12 5 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.5210806863375e-19 1.54606986904162e-17 1.45847499730982 0.386178861788618 12.5 12 5 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 3.24941248775315e-08 3.66977299212121e-07 1.45730688232341 0.385869565217391 12.5 12 5 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000300989843474658 0.00127094524410813 1.45257024023569 0.384615384615385 12.5 12 5 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0312002937334525 0.0702999651527471 1.45257024023569 0.384615384615385 12.5 12 5 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.115992170581069 0.205806557028505 1.45257024023569 0.384615384615385 12.5 12 5 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.115992170581069 0.205806557028505 1.45257024023569 0.384615384615385 12.5 12 5 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.115992170581069 0.205806557028505 1.45257024023569 0.384615384615385 12.5 12 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.115992170581069 0.205806557028505 1.45257024023569 0.384615384615385 12.5 12 5 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.115992170581069 0.205806557028505 1.45257024023569 0.384615384615385 12.5 12 5 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000266957673709483 0.00114421918580902 1.44539705386415 0.382716049382716 12.5 12 5 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0158057470948622 0.0389127649065553 1.44402570941077 0.382352941176471 12.5 12 5 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00255737627826669 0.00801574106602093 1.44200609303397 0.381818181818182 12.5 12 5 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.57183077866901e-06 1.77656077575049e-05 1.44003006549984 0.381294964028777 12.5 12 5 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0546700099048991 0.112746991441553 1.43873623794773 0.380952380952381 12.5 12 5 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0546700099048991 0.112746991441553 1.43873623794773 0.380952380952381 12.5 12 5 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 4.28497838666613e-08 4.61933654865598e-07 1.43592620623299 0.380208333333333 12.5 12 5 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00426910302154007 0.0126297995834751 1.43513939735286 0.38 12.5 12 5 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000343976156837244 0.00143122243034912 1.42777026052435 0.378048780487805 12.5 12 5 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00715560850965281 0.0194321200557938 1.42674676929816 0.377777777777778 12.5 12 5 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00198482246272962 0.00642084175741124 1.42399508796876 0.377049180327869 12.5 12 5 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.21985225687771e-06 2.76721187167603e-05 1.41960410712395 0.375886524822695 12.5 12 5 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0979784098983373 0.183649833943621 1.41625598422979 0.375 12.5 12 5 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0979784098983373 0.183649833943621 1.41625598422979 0.375 12.5 12 5 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0979784098983373 0.183649833943621 1.41625598422979 0.375 12.5 12 5 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0470420460392487 0.0988567497865341 1.41625598422979 0.375 12.5 12 5 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.70276195632627e-06 4.66968278936021e-05 1.40276783199903 0.371428571428571 12.5 12 5 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00135041612783267 0.0046304630118214 1.40276783199903 0.371428571428571 12.5 12 5 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0405069246678583 0.0873353845490339 1.39877134244918 0.37037037037037 12.5 12 5 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0405069246678583 0.0873353845490339 1.39877134244918 0.37037037037037 12.5 12 5 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0405069246678583 0.0873353845490339 1.39877134244918 0.37037037037037 12.5 12 5 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000635529014842518 0.00237988891610764 1.39877134244918 0.37037037037037 12.5 12 5 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00917583799503867 0.024224893259629 1.39573053518299 0.369565217391304 12.5 12 5 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0830742232408171 0.15931889443623 1.39140938801524 0.368421052631579 12.5 12 5 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0830742232408171 0.15931889443623 1.39140938801524 0.368421052631579 12.5 12 5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00195250389148406 0.00637250696693077 1.38848625904882 0.367647058823529 12.5 12 5 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.59521277984342e-06 2.98583917156036e-05 1.37765781275183 0.364779874213836 12.5 12 5 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000705528915501092 0.00260770817339754 1.37737836897643 0.364705882352941 12.5 12 5 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000705528915501092 0.00260770817339754 1.37737836897643 0.364705882352941 12.5 12 5 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000139673574659675 0.000628973090951637 1.37333913622283 0.363636363636364 12.5 12 5 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00608915043845431 0.0169899236743539 1.37333913622283 0.363636363636364 12.5 12 5 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.03011257307962 0.0692248650925675 1.37333913622283 0.363636363636364 12.5 12 5 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0706671643902603 0.138131009515577 1.37333913622283 0.363636363636364 12.5 12 5 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 6.52467171700716e-06 4.03678602317443e-05 1.37115229046451 0.363057324840764 12.5 12 5 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00100958954294451 0.00353853674780797 1.36506600889619 0.36144578313253 12.5 12 5 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.000884574414446068 0.00314687347939189 1.36136234143019 0.36046511627907 12.5 12 5 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0602814841923352 0.122894773647125 1.3596057448606 0.36 12.5 12 5 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0224650167087684 0.0538177083780766 1.35573222421997 0.358974358974359 12.5 12 5 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0515461423949467 0.108026746138452 1.34881522307599 0.357142857142857 12.5 12 5 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.150705923957298 0.262169351823026 1.34881522307599 0.357142857142857 12.5 12 5 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.150705923957298 0.262169351823026 1.34881522307599 0.357142857142857 12.5 12 5 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.150705923957298 0.262169351823026 1.34881522307599 0.357142857142857 12.5 12 5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000350486276457487 0.00144562890260581 1.34125177322697 0.355140186915888 12.5 12 5 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 0.000112790488360175 0.000536792190423172 1.33819463076831 0.354330708661417 12.5 12 5 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.45546279515626e-41 8.7353088937684e-39 1.33610205183202 0.353776630083925 12.5 12 5 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.125729665605255 0.221976816571065 1.33294680868687 0.352941176470588 12.5 12 5 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.125729665605255 0.221976816571065 1.33294680868687 0.352941176470588 12.5 12 5 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.125729665605255 0.221976816571065 1.33294680868687 0.352941176470588 12.5 12 5 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.125729665605255 0.221976816571065 1.33294680868687 0.352941176470588 12.5 12 5 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 3.28512419034532e-07 2.68662742693183e-06 1.32913294085085 0.351931330472103 12.5 12 5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.6665728628975e-05 0.000147647205599344 1.32183891861447 0.35 12.5 12 5 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.105630924024438 0.19648732664938 1.32183891861447 0.35 12.5 12 5 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 7.18878897883389e-05 0.000355196066558355 1.32051840021426 0.34965034965035 12.5 12 5 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 0.000222515882965684 0.00096536616298832 1.3203036817752 0.349593495934959 12.5 12 5 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 5.17361086159525e-06 3.31623795317569e-05 1.31790487421384 0.348958333333333 12.5 12 5 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0242011812156182 0.0562717007676873 1.31744742719051 0.348837209302326 12.5 12 5 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000531850317667301 0.00209646260953066 1.31664164894758 0.348623853211009 12.5 12 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00622625426012726 0.0173384732136225 1.31611667221355 0.348484848484849 12.5 12 5 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.000311307642058552 0.00130291404308624 1.31091463003088 0.347107438016529 12.5 12 5 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.000272373783801318 0.00116044279745292 1.3096560714383 0.346774193548387 12.5 12 5 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.0756774085529203 0.145919989662338 1.30731321621212 0.346153846153846 12.5 12 5 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0756774085529203 0.145919989662338 1.30731321621212 0.346153846153846 12.5 12 5 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0756774085529203 0.145919989662338 1.30731321621212 0.346153846153846 12.5 12 5 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 6.30475704205994e-05 0.0003126017167544 1.29898638044007 0.343949044585987 12.5 12 5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0470388445351547 0.0988567497865341 1.29486261415295 0.342857142857143 12.5 12 5 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0297982051050829 0.0689477168528992 1.2875054402089 0.340909090909091 12.5 12 5 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0191169195015119 0.0466610230714434 1.28264692911378 0.339622641509434 12.5 12 5 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.3071320511975e-10 2.69572305631021e-09 1.27865263748101 0.338565022421525 12.5 12 5 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00302868513903586 0.00932861245205202 1.27257784090213 0.33695652173913 12.5 12 5 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0312224722252538 0.0702999651527471 1.25889420820426 0.333333333333333 12.5 12 5 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.0791612703624422 0.152430971212118 1.25889420820426 0.333333333333333 12.5 12 5 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.18913387491535 0.318883298583582 1.25889420820426 0.333333333333333 12.5 12 5 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00637631262808578 0.0175842885072986 1.25889420820426 0.333333333333333 12.5 12 5 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0674099902498684 0.131945551754557 1.25889420820426 0.333333333333333 12.5 12 5 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0932626504954511 0.176245354123542 1.25889420820426 0.333333333333333 12.5 12 5 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0932626504954511 0.176245354123542 1.25889420820426 0.333333333333333 12.5 12 5 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0932626504954511 0.176245354123542 1.25889420820426 0.333333333333333 12.5 12 5 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.156816318275031 0.270812646729816 1.25889420820426 0.333333333333333 12.5 12 5 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.156816318275031 0.270812646729816 1.25889420820426 0.333333333333333 12.5 12 5 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.156816318275031 0.270812646729816 1.25889420820426 0.333333333333333 12.5 12 5 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.156816318275031 0.270812646729816 1.25889420820426 0.333333333333333 12.5 12 5 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00577398382960105 0.0161739743888234 1.24458859220194 0.329545454545455 12.5 12 5 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00664268394194548 0.018108312738292 1.24408368810774 0.329411764705882 12.5 12 5 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00664268394194548 0.018108312738292 1.24408368810774 0.329411764705882 12.5 12 5 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00664268394194548 0.018108312738292 1.24408368810774 0.329411764705882 12.5 12 5 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00664268394194548 0.018108312738292 1.24408368810774 0.329411764705882 12.5 12 5 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00664268394194548 0.018108312738292 1.24408368810774 0.329411764705882 12.5 12 5 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.19939601508726e-11 2.94265608529167e-10 1.24346117938214 0.329246935201401 12.5 12 5 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0240951965780924 0.0561251528353227 1.23718913564902 0.327586206896552 12.5 12 5 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0240951965780924 0.0561251528353227 1.23718913564902 0.327586206896552 12.5 12 5 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0240951965780924 0.0561251528353227 1.23718913564902 0.327586206896552 12.5 12 5 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0437423528170549 0.0936331307018308 1.23152694280852 0.326086956521739 12.5 12 5 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0437423528170549 0.0936331307018308 1.23152694280852 0.326086956521739 12.5 12 5 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00688316801739619 0.0187280078178868 1.23060445071653 0.325842696629214 12.5 12 5 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.40701991887636e-12 1.10186121467297e-10 1.22756869135937 0.325038880248834 12.5 12 5 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.00064597260260867 0.00241264832942818 1.21828471761703 0.32258064516129 12.5 12 5 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000664596566222775 0.00246924520557444 1.21138876638523 0.320754716981132 12.5 12 5 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000664596566222775 0.00246924520557444 1.21138876638523 0.320754716981132 12.5 12 5 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00634676230065881 0.0175367820462864 1.20853843987609 0.32 12.5 12 5 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.00634676230065881 0.0175367820462864 1.20853843987609 0.32 12.5 12 5 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.044890246651368 0.0957703463041928 1.20853843987609 0.32 12.5 12 5 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 8.82888883621829e-05 0.000431735698073493 1.20244155312784 0.318385650224215 12.5 12 5 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.15931868220805 0.274467899251883 1.20167174419498 0.318181818181818 12.5 12 5 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.190851131367744 0.320202504397389 1.19263661829877 0.315789473684211 12.5 12 5 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.114391132389493 0.204495705264131 1.1802133201915 0.3125 12.5 12 5 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.230568177195811 0.362918370440677 1.1802133201915 0.3125 12.5 12 5 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.230568177195811 0.362918370440677 1.1802133201915 0.3125 12.5 12 5 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0617556900714928 0.125540495673906 1.1802133201915 0.3125 12.5 12 5 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0617556900714928 0.125540495673906 1.1802133201915 0.3125 12.5 12 5 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.134898695373526 0.237869694568187 1.17207391798328 0.310344827586207 12.5 12 5 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.083877194882243 0.160642326133825 1.16897319333253 0.30952380952381 12.5 12 5 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0980243094934538 0.183649833943621 1.16205619218855 0.307692307692308 12.5 12 5 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.15970680400935 0.274471959064379 1.16205619218855 0.307692307692308 12.5 12 5 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.15970680400935 0.274471959064379 1.16205619218855 0.307692307692308 12.5 12 5 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.114811196018761 0.204989124133872 1.15398635752057 0.305555555555556 12.5 12 5 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 8.22871176750557e-06 4.94069909078499e-05 1.15118133477502 0.304812834224599 12.5 12 5 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0028702186492435 0.00885969878063667 1.14942514662128 0.304347826086957 12.5 12 5 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.189986800362935 0.319186796831708 1.14942514662128 0.304347826086957 12.5 12 5 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.189986800362935 0.319186796831708 1.14942514662128 0.304347826086957 12.5 12 5 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00329228486217791 0.0100319515179425 1.14232992966683 0.302469135802469 12.5 12 5 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0725693411880619 0.141654557627726 1.14013060365669 0.30188679245283 12.5 12 5 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.158786163235418 0.273882073071516 1.13300478738384 0.3 12.5 12 5 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.227374077372019 0.361512080559087 1.13300478738384 0.3 12.5 12 5 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.227374077372019 0.361512080559087 1.13300478738384 0.3 12.5 12 5 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.227374077372019 0.361512080559087 1.13300478738384 0.3 12.5 12 5 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.227374077372019 0.361512080559087 1.13300478738384 0.3 12.5 12 5 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00632807232102296 0.0175367820462864 1.12082194020767 0.296774193548387 12.5 12 5 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.274250890358543 0.427762635006724 1.11078900723905 0.294117647058824 12.5 12 5 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0136896747752185 0.0346626462724839 1.10268105828111 0.291970802919708 12.5 12 5 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.112667403295348 0.202483997863479 1.10153243217873 0.291666666666667 12.5 12 5 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.184543257257151 0.311512520850446 1.09645624585532 0.290322580645161 12.5 12 5 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00476502788346052 0.0140385811142118 1.09274573402502 0.289340101522843 12.5 12 5 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0458602213282266 0.0976932559132732 1.09104164711036 0.288888888888889 12.5 12 5 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0153576062273423 0.0378749976802566 1.09045061696566 0.288732394366197 12.5 12 5 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.217547364898797 0.351384676788863 1.0790521784608 0.285714285714286 12.5 12 5 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0195824658394993 0.0476339297258249 1.0790521784608 0.285714285714286 12.5 12 5 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0805683403151458 0.154930740903314 1.0790521784608 0.285714285714286 12.5 12 5 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.211994088727104 0.34280407756667 1.06219198817235 0.28125 12.5 12 5 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0313520511239437 0.0704802033955321 1.0552495568771 0.279411764705882 12.5 12 5 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0878308358028673 0.166644372463307 1.0517344017909 0.278481012658228 12.5 12 5 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0348673858544463 0.0776467763237512 1.04754700536705 0.277372262773723 12.5 12 5 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0730261982101268 0.142351068565768 1.044614342978 0.276595744680851 12.5 12 5 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.0620661146446172 0.125991556546777 1.0430837725121 0.276190476190476 12.5 12 5 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.160494608611053 0.275493158086284 1.03000435216712 0.272727272727273 12.5 12 5 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.240935228526596 0.378005325461242 1.03000435216712 0.272727272727273 12.5 12 5 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.189621725419238 0.319186796831708 1.02285154416596 0.270833333333333 12.5 12 5 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.106755408168791 0.198061207071954 1.02192588665993 0.270588235294118 12.5 12 5 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.106755408168791 0.198061207071954 1.02192588665993 0.270588235294118 12.5 12 5 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0381120198694564 0.0840827973243976 1.01947261032492 0.269938650306748 12.5 12 5 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.225650040653107 0.360381602524548 1.0132563139205 0.268292682926829 12.5 12 5 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0164864921983912 0.0405186155411237 1.00711536656341 0.266666666666667 12.5 12 5 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00176660492675128 0.00581916391381266 0.999485704695505 0.264646464646465 12.5 12 5 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.155383399024501 0.269647044892517 0.993863848582312 0.263157894736842 12.5 12 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.365334784217528 0.532918405816897 0.993863848582312 0.263157894736842 12.5 12 5 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.365334784217528 0.532918405816897 0.993863848582312 0.263157894736842 12.5 12 5 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.192627967631326 0.320202504397389 0.99060527858696 0.262295081967213 12.5 12 5 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.2517651059626 0.394127333096568 0.989131163589063 0.261904761904762 12.5 12 5 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.346728462865227 0.513417900787947 0.985221554246814 0.260869565217391 12.5 12 5 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.100258053472835 0.186737185984089 0.981342729230094 0.259842519685039 12.5 12 5 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.330361592311607 0.494326546645023 0.979139939714426 0.259259259259259 12.5 12 5 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.330361592311607 0.494326546645023 0.979139939714426 0.259259259259259 12.5 12 5 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.151904853321754 0.263932364196405 0.974627774093622 0.258064516129032 12.5 12 5 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.315695080066726 0.474376028442399 0.974627774093622 0.258064516129032 12.5 12 5 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.268364909914784 0.419651941548064 0.964259393518158 0.25531914893617 12.5 12 5 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.135237643932881 0.238172236777834 0.959648863631118 0.254098360655738 12.5 12 5 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.207164042253344 0.338844174858056 0.944170656153196 0.25 12.5 12 5 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.367966334782544 0.532918405816897 0.944170656153196 0.25 12.5 12 5 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.367966334782544 0.532918405816897 0.944170656153196 0.25 12.5 12 5 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.236454708489151 0.371385265099405 0.944170656153196 0.25 12.5 12 5 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.334390478410608 0.496181074847023 0.944170656153196 0.25 12.5 12 5 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.411321686499366 0.579334576455875 0.944170656153196 0.25 12.5 12 5 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.411321686499366 0.579334576455875 0.944170656153196 0.25 12.5 12 5 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.411321686499366 0.579334576455875 0.944170656153196 0.25 12.5 12 5 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.321537096309474 0.482136236088917 0.924901867252111 0.244897959183673 12.5 12 5 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.321537096309474 0.482136236088917 0.924901867252111 0.244897959183673 12.5 12 5 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.335365715571769 0.497109805477737 0.923189086016459 0.244444444444444 12.5 12 5 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.385246668749002 0.546021921942062 0.915559424148554 0.242424242424242 12.5 12 5 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.385246668749002 0.546021921942062 0.915559424148554 0.242424242424242 12.5 12 5 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.385246668749002 0.546021921942062 0.915559424148554 0.242424242424242 12.5 12 5 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.287213565386644 0.432034781760248 0.908316074273961 0.240506329113924 12.5 12 5 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.429299046228418 0.597742214073424 0.906403829907068 0.24 12.5 12 5 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.429299046228418 0.597742214073424 0.906403829907068 0.24 12.5 12 5 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.429299046228418 0.597742214073424 0.906403829907068 0.24 12.5 12 5 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.429299046228418 0.597742214073424 0.906403829907068 0.24 12.5 12 5 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.429299046228418 0.597742214073424 0.906403829907068 0.24 12.5 12 5 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.197860167140155 0.323998869781864 0.900255741913513 0.238372093023256 12.5 12 5 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.456772477315685 0.627400806197123 0.89921014871733 0.238095238095238 12.5 12 5 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.19244015734558 0.320202504397389 0.898238029637635 0.237837837837838 12.5 12 5 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.443535683834899 0.614558206520994 0.881225945742983 0.233333333333333 12.5 12 5 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.432651470119873 0.60123343943416 0.871542144141412 0.230769230769231 12.5 12 5 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.432651470119873 0.60123343943416 0.871542144141412 0.230769230769231 12.5 12 5 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.398023107271201 0.562449733512333 0.86677961876359 0.229508196721311 12.5 12 5 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.501164578433003 0.679593576188232 0.858336960139269 0.227272727272727 12.5 12 5 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.423914952694462 0.593147470682615 0.852799302331919 0.225806451612903 12.5 12 5 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.480822526600615 0.656631914925792 0.852799302331919 0.225806451612903 12.5 12 5 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.480822526600615 0.656631914925792 0.852799302331919 0.225806451612903 12.5 12 5 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.461075588931433 0.632700639391928 0.839262805469508 0.222222222222222 12.5 12 5 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.482029102652568 0.65764852643778 0.821017961872345 0.217391304347826 12.5 12 5 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.504609292254304 0.679593576188232 0.821017961872345 0.217391304347826 12.5 12 5 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.244112520987405 0.382568411195019 0.814289619550659 0.215609756097561 12.5 12 5 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.548731757575027 0.729080570522189 0.809289133845597 0.214285714285714 12.5 12 5 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.479848135630058 0.656561439424589 0.805999340618582 0.213414634146341 12.5 12 5 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.585122436669519 0.774827769819633 0.786808880127664 0.208333333333333 12.5 12 5 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.585122436669519 0.774827769819633 0.786808880127664 0.208333333333333 12.5 12 5 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.567086846637255 0.752765468997028 0.783839790013974 0.207547169811321 12.5 12 5 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.58888848248411 0.777269189430285 0.7747041281257 0.205128205128205 12.5 12 5 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.624078284279795 0.808064966815422 0.755336524922557 0.2 12.5 12 5 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.649366236461937 0.832595857953632 0.736913682851275 0.195121951219512 12.5 12 5 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.763114955202826 0.936939241806404 0.728035204744633 0.192771084337349 12.5 12 5 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.717141815372415 0.896742357886597 0.686669568111415 0.181818181818182 12.5 12 5 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.726805040131841 0.906436084231034 0.674407611537997 0.178571428571429 12.5 12 5 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.849372366186821 1 0.653656608106059 0.173076923076923 12.5 12 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.756136093815905 0.929172419257368 0.651152176657377 0.172413793103448 12.5 12 5 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.837000063883068 1 0.638312556272583 0.169014084507042 12.5 12 5 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.783036101158746 0.960569286162841 0.629447104102131 0.166666666666667 12.5 12 5 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.905274316256609 1 0.610372949432369 0.161616161616162 12.5 12 5 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.836320905603545 1 0.596318309149387 0.157894736842105 12.5 12 5 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.887932915808849 1 0.590106660095748 0.15625 12.5 12 5 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.98361076394839 1 0.568532868221279 0.150537634408602 12.5 12 5 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.951671909963521 1 0.556563755206095 0.147368421052632 12.5 12 5 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.86808395904688 1 0.555394503619527 0.147058823529412 12.5 12 5 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.86808395904688 1 0.555394503619527 0.147058823529412 12.5 12 5 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.996649666175695 1 0.547989243571267 0.145098039215686 12.5 12 5 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.884307535635028 1 0.539526089230398 0.142857142857143 12.5 12 5 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999218284389082 1 0.487313887046811 0.129032258064516 12.5 12 5 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.989885828013332 1 0.467218469024262 0.123711340206186 12.5 12 5 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999111516056 1 0.447751032814918 0.118556701030928 12.5 12 5 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.402719305899096 0.106633081444165 12.5 12 5 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.987707505668874 1 0.397545539432925 0.105263157894737 12.5 12 5 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.982677819605489 1 0.393404440063832 0.104166666666667 12.5 12 5 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999212495184 1 0.391156414692038 0.103571428571429 12.5 12 5 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.995178093315197 1 0.359684059486932 0.0952380952380952 12.5 12 5 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.338057486289933 0.0895117540687161 12.5 12 5 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999997009291 1 0.214584240034817 0.0568181818181818 12.5 12 5 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999998359774614 1 0.209815701367377 0.0555555555555556 12.5 12 5 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 3.30879382390751e-06 1.39715537430872e-05 0.878925505400166 1 12.4 12 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 3.30879382390751e-06 1.39715537430872e-05 0.878925505400166 1 12.4 12 4 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00182136885770022 0.00461997840375653 0.878925505400166 1 12.4 12 4 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00182136885770022 0.00461997840375653 0.878925505400166 1 12.4 12 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00182136885770022 0.00461997840375653 0.878925505400166 1 12.4 12 4 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00182136885770022 0.00461997840375653 0.878925505400166 1 12.4 12 4 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00182136885770022 0.00461997840375653 0.878925505400166 1 12.4 12 4 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00182136885770022 0.00461997840375653 0.878925505400166 1 12.4 12 4 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00182136885770022 0.00461997840375653 0.878925505400166 1 12.4 12 4 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%REACT_215995.1 NOSTRIN MEDIATED ENOS TRAFFICKING 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_196569.2 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.0426913272416403 0.0726671754364284 0.878925505400166 1 12.4 12 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 7.49362329245026e-08 4.46168449588147e-07 0.878925505400166 1 12.4 12 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.64888376903828e-07 1.39090834071641e-06 0.878925505400166 1 12.4 12 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 2.64888376903828e-07 1.39090834071641e-06 0.878925505400166 1 12.4 12 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.76009015497204e-06 8.02759067476029e-06 0.878925505400166 1 12.4 12 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.76009015497204e-06 8.02759067476029e-06 0.878925505400166 1 12.4 12 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 2.19789258881762e-05 8.27407712668643e-05 0.878925505400166 1 12.4 12 4 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 2.19789258881762e-05 8.27407712668643e-05 0.878925505400166 1 12.4 12 4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.19789258881762e-05 8.27407712668643e-05 0.878925505400166 1 12.4 12 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 4.13138987203435e-05 0.000144802162263667 0.878925505400166 1 12.4 12 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 4.13138987203435e-05 0.000144802162263667 0.878925505400166 1 12.4 12 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 4.13138987203435e-05 0.000144802162263667 0.878925505400166 1 12.4 12 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 4.13138987203435e-05 0.000144802162263667 0.878925505400166 1 12.4 12 4 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 4.13138987203435e-05 0.000144802162263667 0.878925505400166 1 12.4 12 4 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 7.76559308042201e-05 0.000261239691570698 0.878925505400166 1 12.4 12 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000145962674661665 0.000466752552906853 0.878925505400166 1 12.4 12 4 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000145962674661665 0.000466752552906853 0.878925505400166 1 12.4 12 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000145962674661665 0.000466752552906853 0.878925505400166 1 12.4 12 4 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000145962674661665 0.000466752552906853 0.878925505400166 1 12.4 12 4 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000274345430686826 0.000835960487938659 0.878925505400166 1 12.4 12 4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000274345430686826 0.000835960487938659 0.878925505400166 1 12.4 12 4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000274345430686826 0.000835960487938659 0.878925505400166 1 12.4 12 4 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000274345430686826 0.000835960487938659 0.878925505400166 1 12.4 12 4 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.000274345430686826 0.000835960487938659 0.878925505400166 1 12.4 12 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000515634996699643 0.00148532105324614 0.878925505400166 1 12.4 12 4 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000515634996699643 0.00148532105324614 0.878925505400166 1 12.4 12 4 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.000515634996699643 0.00148532105324614 0.878925505400166 1 12.4 12 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000515634996699643 0.00148532105324614 0.878925505400166 1 12.4 12 4 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000515634996699643 0.00148532105324614 0.878925505400166 1 12.4 12 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000515634996699643 0.00148532105324614 0.878925505400166 1 12.4 12 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000515634996699643 0.00148532105324614 0.878925505400166 1 12.4 12 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000515634996699643 0.00148532105324614 0.878925505400166 1 12.4 12 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000969116029875582 0.00263177883685678 0.878925505400166 1 12.4 12 4 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.00342301478493311 0.00793924224991246 0.878925505400166 1 12.4 12 4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00643292344687713 0.0141266204705342 0.878925505400166 1 12.4 12 4 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0120891768920507 0.0243160667095219 0.878925505400166 1 12.4 12 4 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0227181950149358 0.04155268831138 0.878925505400166 1 12.4 12 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.62340847673729e-12 2.8172076370697e-11 0.860988250187918 0.979591836734694 12.4 12 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.43347738980159e-09 3.18628198267053e-08 0.854510908027939 0.972222222222222 12.4 12 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 4.43347738980159e-09 3.18628198267053e-08 0.854510908027939 0.972222222222222 12.4 12 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 2.71000252800183e-08 1.69137438480114e-07 0.852291399175919 0.96969696969697 12.4 12 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 1.64333616946894e-07 8.89151090933197e-07 0.849627988553494 0.966666666666667 12.4 12 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.64333616946894e-07 8.89151090933197e-07 0.849627988553494 0.966666666666667 12.4 12 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 9.96910428442108e-13 1.75136239465817e-11 0.846964577931069 0.963636363636364 12.4 12 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 5.94189127255611e-12 9.30247687513487e-11 0.845120678269391 0.961538461538462 12.4 12 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.78975820115812e-06 8.13682402635143e-06 0.845120678269391 0.961538461538462 12.4 12 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 3.24082724634586e-06 1.37662602135825e-05 0.84376848518416 0.96 12.4 12 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.24082724634586e-06 1.37662602135825e-05 0.84376848518416 0.96 12.4 12 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.24082724634586e-06 1.37662602135825e-05 0.84376848518416 0.96 12.4 12 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.24082724634586e-06 1.37662602135825e-05 0.84376848518416 0.96 12.4 12 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 5.85962704560859e-06 2.36882081985824e-05 0.842303609341826 0.958333333333333 12.4 12 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 5.85962704560859e-06 2.36882081985824e-05 0.842303609341826 0.958333333333333 12.4 12 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.37970489668519e-15 3.27220011330505e-14 0.841787807988891 0.957746478873239 12.4 12 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.06703680543879e-10 1.80453581235546e-09 0.840711352991463 0.956521739130435 12.4 12 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.05775474403599e-05 4.19271587956325e-05 0.840711352991463 0.956521739130435 12.4 12 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 1.90608683767894e-05 7.31094762807853e-05 0.838974346063795 0.954545454545455 12.4 12 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.90608683767894e-05 7.31094762807853e-05 0.838974346063795 0.954545454545455 12.4 12 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 3.42828672026169e-05 0.00012413363875146 0.83707190990492 0.952380952380952 12.4 12 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 3.42828672026169e-05 0.00012413363875146 0.83707190990492 0.952380952380952 12.4 12 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 6.15337319383322e-05 0.00020998201570323 0.834979230130158 0.95 12.4 12 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 6.15337319383322e-05 0.00020998201570323 0.834979230130158 0.95 12.4 12 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 6.15337319383322e-05 0.00020998201570323 0.834979230130158 0.95 12.4 12 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 6.15337319383322e-05 0.00020998201570323 0.834979230130158 0.95 12.4 12 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 6.15337319383322e-05 0.00020998201570323 0.834979230130158 0.95 12.4 12 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 2.2219239350545e-08 1.41784652896078e-07 0.832666268273842 0.947368421052632 12.4 12 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 2.2219239350545e-08 1.41784652896078e-07 0.832666268273842 0.947368421052632 12.4 12 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000110195796145224 0.000361310179526851 0.832666268273842 0.947368421052632 12.4 12 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000110195796145224 0.000361310179526851 0.832666268273842 0.947368421052632 12.4 12 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000110195796145224 0.000361310179526851 0.832666268273842 0.947368421052632 12.4 12 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000196849034527423 0.000608948208983745 0.830096310655712 0.944444444444444 12.4 12 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000196849034527423 0.000608948208983745 0.830096310655712 0.944444444444444 12.4 12 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 1.25729949688656e-07 7.27291538239666e-07 0.828701190805871 0.942857142857143 12.4 12 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.23360186568745e-07 1.19489302814784e-06 0.827224005082509 0.941176470588235 12.4 12 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000350673464035021 0.00103960070692049 0.827224005082509 0.941176470588235 12.4 12 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000350673464035021 0.00103960070692049 0.827224005082509 0.941176470588235 12.4 12 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000350673464035021 0.00103960070692049 0.827224005082509 0.941176470588235 12.4 12 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000350673464035021 0.00103960070692049 0.827224005082509 0.941176470588235 12.4 12 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000350673464035021 0.00103960070692049 0.827224005082509 0.941176470588235 12.4 12 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 8.81387929120879e-10 7.24979782161278e-09 0.823992661312656 0.9375 12.4 12 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 7.01296704810369e-07 3.38286512184798e-06 0.823992661312656 0.9375 12.4 12 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000622786412062365 0.0017479784306997 0.823992661312656 0.9375 12.4 12 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000622786412062365 0.0017479784306997 0.823992661312656 0.9375 12.4 12 4 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.000622786412062365 0.0017479784306997 0.823992661312656 0.9375 12.4 12 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000622786412062365 0.0017479784306997 0.823992661312656 0.9375 12.4 12 4 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000622786412062365 0.0017479784306997 0.823992661312656 0.9375 12.4 12 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.12194553368793e-11 1.28048796603779e-10 0.820330471706822 0.933333333333333 12.4 12 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.12194553368793e-11 1.28048796603779e-10 0.820330471706822 0.933333333333333 12.4 12 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.12194553368793e-11 1.28048796603779e-10 0.820330471706822 0.933333333333333 12.4 12 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.12194553368793e-11 1.28048796603779e-10 0.820330471706822 0.933333333333333 12.4 12 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.12194553368793e-11 1.28048796603779e-10 0.820330471706822 0.933333333333333 12.4 12 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.12194553368793e-11 1.28048796603779e-10 0.820330471706822 0.933333333333333 12.4 12 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.12194553368793e-11 1.28048796603779e-10 0.820330471706822 0.933333333333333 12.4 12 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.18526992375587e-06 9.62736563933315e-06 0.820330471706822 0.933333333333333 12.4 12 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0011022570886659 0.00295945629655014 0.820330471706822 0.933333333333333 12.4 12 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0011022570886659 0.00295945629655014 0.820330471706822 0.933333333333333 12.4 12 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0011022570886659 0.00295945629655014 0.820330471706822 0.933333333333333 12.4 12 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0011022570886659 0.00295945629655014 0.820330471706822 0.933333333333333 12.4 12 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0011022570886659 0.00295945629655014 0.820330471706822 0.933333333333333 12.4 12 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0011022570886659 0.00295945629655014 0.820330471706822 0.933333333333333 12.4 12 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 3.84537919571037e-06 1.59532787040695e-05 0.818309953303603 0.931034482758621 12.4 12 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.49384653372213e-08 9.84140563651198e-08 0.81760512130248 0.930232558139535 12.4 12 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 2.61897763354757e-08 1.64902883740628e-07 0.816145112157297 0.928571428571429 12.4 12 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 6.7511840233123e-06 2.70617883526011e-05 0.816145112157297 0.928571428571429 12.4 12 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00194332125901392 0.00489441796739259 0.816145112157297 0.928571428571429 12.4 12 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00194332125901392 0.00489441796739259 0.816145112157297 0.928571428571429 12.4 12 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00194332125901392 0.00489441796739259 0.816145112157297 0.928571428571429 12.4 12 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.29396690384277e-15 7.56018532930365e-14 0.815388721877263 0.927710843373494 12.4 12 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.06024121197345e-19 4.80603166641814e-18 0.815003650461972 0.927272727272727 12.4 12 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.58371726443472e-08 2.81147830486664e-07 0.814613883053813 0.926829268292683 12.4 12 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.58371726443472e-08 2.81147830486664e-07 0.814613883053813 0.926829268292683 12.4 12 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 3.25719836440069e-10 2.77544507337855e-09 0.813819912407561 0.925925925925926 12.4 12 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.18238291610714e-05 4.60967367019303e-05 0.813819912407561 0.925925925925926 12.4 12 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.18238291610714e-05 4.60967367019303e-05 0.813819912407561 0.925925925925926 12.4 12 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 1.18238291610714e-05 4.60967367019303e-05 0.813819912407561 0.925925925925926 12.4 12 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.65096817543118e-19 2.11613887201015e-17 0.813211448921649 0.925233644859813 12.4 12 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 2.06536557885985e-05 7.83737391658017e-05 0.811315851138615 0.923076923076923 12.4 12 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 2.06536557885985e-05 7.83737391658017e-05 0.811315851138615 0.923076923076923 12.4 12 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.06536557885985e-05 7.83737391658017e-05 0.811315851138615 0.923076923076923 12.4 12 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 2.06536557885985e-05 7.83737391658017e-05 0.811315851138615 0.923076923076923 12.4 12 4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00341110978885343 0.00793924224991246 0.811315851138615 0.923076923076923 12.4 12 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00341110978885343 0.00793924224991246 0.811315851138615 0.923076923076923 12.4 12 4 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00341110978885343 0.00793924224991246 0.811315851138615 0.923076923076923 12.4 12 4 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00341110978885343 0.00793924224991246 0.811315851138615 0.923076923076923 12.4 12 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00341110978885343 0.00793924224991246 0.811315851138615 0.923076923076923 12.4 12 4 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00341110978885343 0.00793924224991246 0.811315851138615 0.923076923076923 12.4 12 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00341110978885343 0.00793924224991246 0.811315851138615 0.923076923076923 12.4 12 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.72304873888097e-09 1.36216575301534e-08 0.80999017164329 0.92156862745098 12.4 12 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.72304873888097e-09 1.36216575301534e-08 0.80999017164329 0.92156862745098 12.4 12 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 3.59758247371302e-05 0.000127983996502341 0.808611464968153 0.92 12.4 12 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 3.59758247371302e-05 0.000127983996502341 0.808611464968153 0.92 12.4 12 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 3.59758247371302e-05 0.000127983996502341 0.808611464968153 0.92 12.4 12 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 3.59758247371302e-05 0.000127983996502341 0.808611464968153 0.92 12.4 12 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 3.59758247371302e-05 0.000127983996502341 0.808611464968153 0.92 12.4 12 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 3.59758247371302e-05 0.000127983996502341 0.808611464968153 0.92 12.4 12 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 4.73322230009007e-17 1.32066183000552e-15 0.807901222135506 0.919191919191919 12.4 12 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 4.22096049043626e-07 2.12241228900735e-06 0.807661275232585 0.918918918918919 12.4 12 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 4.22096049043626e-07 2.12241228900735e-06 0.807661275232585 0.918918918918919 12.4 12 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4.22096049043626e-07 2.12241228900735e-06 0.807661275232585 0.918918918918919 12.4 12 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.08818086396879e-14 2.31116622302625e-13 0.806543404955447 0.917647058823529 12.4 12 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.08818086396879e-14 2.31116622302625e-13 0.806543404955447 0.917647058823529 12.4 12 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.08818086396879e-14 2.31116622302625e-13 0.806543404955447 0.917647058823529 12.4 12 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 7.31488372531322e-07 3.49297971178547e-06 0.805681713283486 0.916666666666667 12.4 12 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 7.31488372531322e-07 3.49297971178547e-06 0.805681713283486 0.916666666666667 12.4 12 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 7.31488372531322e-07 3.49297971178547e-06 0.805681713283486 0.916666666666667 12.4 12 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 6.2474671782623e-05 0.000211167358543165 0.805681713283486 0.916666666666667 12.4 12 4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 6.2474671782623e-05 0.000211167358543165 0.805681713283486 0.916666666666667 12.4 12 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 6.2474671782623e-05 0.000211167358543165 0.805681713283486 0.916666666666667 12.4 12 4 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 6.2474671782623e-05 0.000211167358543165 0.805681713283486 0.916666666666667 12.4 12 4 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00595740739481089 0.0133083056873091 0.805681713283486 0.916666666666667 12.4 12 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00595740739481089 0.0133083056873091 0.805681713283486 0.916666666666667 12.4 12 4 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00595740739481089 0.0133083056873091 0.805681713283486 0.916666666666667 12.4 12 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00595740739481089 0.0133083056873091 0.805681713283486 0.916666666666667 12.4 12 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00595740739481089 0.0133083056873091 0.805681713283486 0.916666666666667 12.4 12 4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00595740739481089 0.0133083056873091 0.805681713283486 0.916666666666667 12.4 12 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.55305223069271e-08 1.01843010335287e-07 0.804123334727812 0.914893617021277 12.4 12 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 1.26474937995637e-06 5.84330638856466e-06 0.803589033508723 0.914285714285714 12.4 12 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 1.26474937995637e-06 5.84330638856466e-06 0.803589033508723 0.914285714285714 12.4 12 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 1.26474937995637e-06 5.84330638856466e-06 0.803589033508723 0.914285714285714 12.4 12 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 1.26474937995637e-06 5.84330638856466e-06 0.803589033508723 0.914285714285714 12.4 12 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 7.46571531213636e-12 1.01178217992096e-10 0.80249720058276 0.91304347826087 12.4 12 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 2.6790470262053e-08 1.67942022832165e-07 0.80249720058276 0.91304347826087 12.4 12 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0001081357382093 0.000357023562579662 0.80249720058276 0.91304347826087 12.4 12 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.01639717069735e-25 7.61227986264384e-24 0.802019523677652 0.9125 12.4 12 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.66657483142332e-13 3.16204798015384e-12 0.802019523677652 0.9125 12.4 12 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 2.18145382637715e-06 9.62736563933315e-06 0.801373254923681 0.911764705882353 12.4 12 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 2.18145382637715e-06 9.62736563933315e-06 0.801373254923681 0.911764705882353 12.4 12 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.00110955684588e-09 8.14045085366679e-09 0.80045001384658 0.910714285714286 12.4 12 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.20849499561707e-11 2.13788325085924e-10 0.800215758647912 0.91044776119403 12.4 12 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000186502855460892 0.000579461928648142 0.799023186727424 0.909090909090909 12.4 12 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000186502855460892 0.000579461928648142 0.799023186727424 0.909090909090909 12.4 12 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000186502855460892 0.000579461928648142 0.799023186727424 0.909090909090909 12.4 12 4 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0103438971359466 0.0214881249992 0.799023186727424 0.909090909090909 12.4 12 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 3.75293220504274e-06 1.56152705490521e-05 0.799023186727424 0.909090909090909 12.4 12 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 6.49642214864507e-11 6.04209720099473e-10 0.797793920286305 0.907692307692308 12.4 12 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 6.43889963246352e-06 2.59562441274663e-05 0.796526239268901 0.90625 12.4 12 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 2.32487437578628e-07 1.23896592669243e-06 0.795218314409674 0.904761904761905 12.4 12 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000320416946927628 0.00095990171679582 0.795218314409674 0.904761904761905 12.4 12 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.000320416946927628 0.00095990171679582 0.795218314409674 0.904761904761905 12.4 12 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000320416946927628 0.00095990171679582 0.795218314409674 0.904761904761905 12.4 12 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000320416946927628 0.00095990171679582 0.795218314409674 0.904761904761905 12.4 12 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000320416946927628 0.00095990171679582 0.795218314409674 0.904761904761905 12.4 12 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000320416946927628 0.00095990171679582 0.795218314409674 0.904761904761905 12.4 12 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000320416946927628 0.00095990171679582 0.795218314409674 0.904761904761905 12.4 12 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 7.23304449199743e-12 1.01178217992096e-10 0.794644977485082 0.904109589041096 12.4 12 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.43193955619245e-16 6.17973212225331e-15 0.794413437573227 0.903846153846154 12.4 12 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 8.61025142166438e-09 5.91902790967556e-08 0.794413437573227 0.903846153846154 12.4 12 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 8.61025142166438e-09 5.91902790967556e-08 0.794413437573227 0.903846153846154 12.4 12 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 8.61025142166438e-09 5.91902790967556e-08 0.794413437573227 0.903846153846154 12.4 12 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.07025836938781e-14 2.31116622302625e-13 0.793868198425957 0.903225806451613 12.4 12 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.10152840722174e-05 4.33004122507332e-05 0.793868198425957 0.903225806451613 12.4 12 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.10152840722174e-05 4.33004122507332e-05 0.793868198425957 0.903225806451613 12.4 12 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 1.10152840722174e-05 4.33004122507332e-05 0.793868198425957 0.903225806451613 12.4 12 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.23294369625115e-11 1.28048796603779e-10 0.793474414597372 0.902777777777778 12.4 12 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 3.96834560077371e-07 2.01676992496464e-06 0.793176675605028 0.902439024390244 12.4 12 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 3.96834560077371e-07 2.01676992496464e-06 0.793176675605028 0.902439024390244 12.4 12 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 3.96834560077371e-07 2.01676992496464e-06 0.793176675605028 0.902439024390244 12.4 12 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 3.96834560077371e-07 2.01676992496464e-06 0.793176675605028 0.902439024390244 12.4 12 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.46771392754973e-08 9.71421822745707e-08 0.792756338204071 0.901960784313726 12.4 12 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 2.49689922161867e-08 1.57915004105038e-07 0.79103295486015 0.9 12.4 12 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 6.75723404251504e-07 3.27059321173432e-06 0.79103295486015 0.9 12.4 12 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 6.75723404251504e-07 3.27059321173432e-06 0.79103295486015 0.9 12.4 12 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000548154374007248 0.00157262837542805 0.79103295486015 0.9 12.4 12 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000548154374007248 0.00157262837542805 0.79103295486015 0.9 12.4 12 4 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0178378281300291 0.0343946198225358 0.79103295486015 0.9 12.4 12 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.79978046364718e-25 1.99204379988497e-23 0.79103295486015 0.9 12.4 12 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 1.87863626433008e-05 7.24471383236233e-05 0.791032954860149 0.9 12.4 12 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.75530088560667e-25 3.2222824572468e-23 0.790512880596599 0.899408284023669 12.4 12 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.3435339214764e-16 3.60726183068097e-15 0.790226601185471 0.899082568807339 12.4 12 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.31935195947038e-12 3.88286804508982e-11 0.789920390929263 0.89873417721519 12.4 12 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.31935195947038e-12 3.88286804508982e-11 0.789920390929263 0.89873417721519 12.4 12 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.59267746938539e-09 1.27324721288506e-08 0.789543250613709 0.898305084745763 12.4 12 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.59267746938539e-09 1.27324721288506e-08 0.789543250613709 0.898305084745763 12.4 12 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 3.19348258625291e-05 0.000117424437215449 0.788002177255321 0.896551724137931 12.4 12 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 3.19348258625291e-05 0.000117424437215449 0.788002177255321 0.896551724137931 12.4 12 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 3.19348258625291e-05 0.000117424437215449 0.788002177255321 0.896551724137931 12.4 12 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 7.18093887841064e-08 4.2934773209993e-07 0.787370765254315 0.895833333333333 12.4 12 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.12527211430139e-23 6.40504887460349e-22 0.787258428149842 0.895705521472393 12.4 12 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.73508688272286e-10 1.53355815783518e-09 0.787097467522537 0.895522388059702 12.4 12 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.73508688272286e-10 1.53355815783518e-09 0.787097467522537 0.895522388059702 12.4 12 4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000933401560776115 0.00258410587740158 0.786407031147517 0.894736842105263 12.4 12 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000933401560776115 0.00258410587740158 0.786407031147517 0.894736842105263 12.4 12 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.86247802167415e-15 4.34476430302018e-14 0.785962230790533 0.894230769230769 12.4 12 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.21374033085111e-07 7.04960200326992e-07 0.785422792059723 0.893617021276596 12.4 12 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.21374033085111e-07 7.04960200326992e-07 0.785422792059723 0.893617021276596 12.4 12 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.89635512956656e-11 1.84829681463919e-10 0.785173451490815 0.893333333333333 12.4 12 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.89635512956656e-11 1.84829681463919e-10 0.785173451490815 0.893333333333333 12.4 12 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.89635512956656e-11 1.84829681463919e-10 0.785173451490815 0.893333333333333 12.4 12 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.89635512956656e-11 1.84829681463919e-10 0.785173451490815 0.893333333333333 12.4 12 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.89635512956656e-11 1.84829681463919e-10 0.785173451490815 0.893333333333333 12.4 12 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 5.40958719757302e-05 0.0001872954399549 0.784754915535863 0.892857142857143 12.4 12 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 5.40958719757302e-05 0.0001872954399549 0.784754915535863 0.892857142857143 12.4 12 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.0466889489398e-07 1.10319635391717e-06 0.783390124378409 0.891304347826087 12.4 12 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 3.06736148139161e-40 5.45606923502533e-38 0.782933641329158 0.890784982935154 12.4 12 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.6662036616116e-29 3.72643415033807e-27 0.7826622357611 0.89047619047619 12.4 12 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.49583735617828e-14 3.08489356208941e-13 0.782243699806148 0.89 12.4 12 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 4.27031643983656e-18 1.44682387949701e-16 0.782036079608022 0.889763779527559 12.4 12 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.47457161286304e-57 3.49719234184018e-55 0.781954851048505 0.889671361502347 12.4 12 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.86619738440829e-12 9.30247687513487e-11 0.781267115911259 0.888888888888889 12.4 12 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.86619738440829e-12 9.30247687513487e-11 0.781267115911259 0.888888888888889 12.4 12 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.39682855759376e-09 1.12936763491814e-08 0.781267115911259 0.888888888888889 12.4 12 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 3.44282497643859e-07 1.78150543326258e-06 0.781267115911259 0.888888888888889 12.4 12 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 3.44282497643859e-07 1.78150543326258e-06 0.781267115911259 0.888888888888889 12.4 12 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 9.1292268808816e-05 0.000304236296287928 0.781267115911259 0.888888888888889 12.4 12 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 9.1292268808816e-05 0.000304236296287928 0.781267115911259 0.888888888888889 12.4 12 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 9.1292268808816e-05 0.000304236296287928 0.781267115911259 0.888888888888889 12.4 12 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.44804534088284e-35 2.06056852007629e-33 0.781267115911259 0.888888888888889 12.4 12 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00158126890009581 0.00406897946625015 0.781267115911259 0.888888888888889 12.4 12 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00158126890009581 0.00406897946625015 0.781267115911259 0.888888888888889 12.4 12 4 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00158126890009581 0.00406897946625015 0.781267115911259 0.888888888888889 12.4 12 4 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00158126890009581 0.00406897946625015 0.781267115911259 0.888888888888889 12.4 12 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00158126890009581 0.00406897946625015 0.781267115911259 0.888888888888889 12.4 12 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00158126890009581 0.00406897946625015 0.781267115911259 0.888888888888889 12.4 12 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0305121927424292 0.0548217806470666 0.781267115911259 0.888888888888889 12.4 12 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.20893730337323e-14 8.43565884887339e-13 0.780270601732801 0.887755102040816 12.4 12 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.6565722679651e-08 2.26230536404971e-07 0.779424504788827 0.886792452830189 12.4 12 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 5.77653784774463e-07 2.85417130463216e-06 0.779047607059238 0.886363636363636 12.4 12 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.77653784774463e-07 2.85417130463216e-06 0.779047607059238 0.886363636363636 12.4 12 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.77653784774463e-07 2.85417130463216e-06 0.779047607059238 0.886363636363636 12.4 12 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.36803408654357e-17 9.98481771906563e-16 0.778885203972505 0.886178861788618 12.4 12 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.64611891255393e-11 1.67316229468875e-10 0.7787947516204 0.886075949367089 12.4 12 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 9.28591328613819e-06 3.69102083971359e-05 0.778476876211576 0.885714285714286 12.4 12 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 4.11294912198261e-19 1.58181800015709e-17 0.777754224203025 0.884892086330935 12.4 12 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.75107590595173e-11 2.64512230687116e-10 0.777511024007839 0.884615384615385 12.4 12 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000153445786675873 0.000485229676532817 0.777511024007839 0.884615384615385 12.4 12 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000153445786675873 0.000485229676532817 0.777511024007839 0.884615384615385 12.4 12 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000153445786675873 0.000485229676532817 0.777511024007839 0.884615384615385 12.4 12 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000153445786675873 0.000485229676532817 0.777511024007839 0.884615384615385 12.4 12 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000153445786675873 0.000485229676532817 0.777511024007839 0.884615384615385 12.4 12 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 5.00078616490984e-12 8.17944679616862e-11 0.775522504764853 0.882352941176471 12.4 12 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.00078616490984e-12 8.17944679616862e-11 0.775522504764853 0.882352941176471 12.4 12 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.61284664778377e-16 6.52294873648474e-15 0.775522504764852 0.882352941176471 12.4 12 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.55390200450346e-05 6.02507507468235e-05 0.775522504764852 0.882352941176471 12.4 12 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00266363352226745 0.00649032620237429 0.775522504764852 0.882352941176471 12.4 12 4 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00266363352226745 0.00649032620237429 0.775522504764852 0.882352941176471 12.4 12 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00266363352226745 0.00649032620237429 0.775522504764852 0.882352941176471 12.4 12 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00266363352226745 0.00649032620237429 0.775522504764852 0.882352941176471 12.4 12 4 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00266363352226745 0.00649032620237429 0.775522504764852 0.882352941176471 12.4 12 4 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00266363352226745 0.00649032620237429 0.775522504764852 0.882352941176471 12.4 12 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.32786370358619e-20 1.14225863800108e-18 0.774842221865936 0.881578947368421 12.4 12 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.27830853925579e-21 2.25482705605963e-19 0.77389667142153 0.880503144654088 12.4 12 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.08711051661366e-66 3.8673956628531e-64 0.773654960076572 0.880228136882129 12.4 12 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.27165187795336e-10 1.16745846601783e-09 0.773454444752146 0.88 12.4 12 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.000256799550116238 0.000792680606974853 0.773454444752146 0.88 12.4 12 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.77704161523964e-24 3.4253042577025e-22 0.773262329887578 0.879781420765027 12.4 12 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 8.77527023737168e-18 2.83800216994998e-16 0.773190106254282 0.879699248120301 12.4 12 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.81475466159101e-08 1.17381631065636e-07 0.772848289231181 0.879310344827586 12.4 12 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.81475466159101e-08 1.17381631065636e-07 0.772848289231181 0.879310344827586 12.4 12 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.18013200219392e-20 5.99759942543552e-19 0.772558724491866 0.878980891719745 12.4 12 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.19155233004752e-16 5.67014357392296e-15 0.771739468156244 0.878048780487805 12.4 12 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.68372308230528e-06 1.16426241085165e-05 0.771739468156244 0.878048780487805 12.4 12 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.68372308230528e-06 1.16426241085165e-05 0.771739468156244 0.878048780487805 12.4 12 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 2.68372308230528e-06 1.16426241085165e-05 0.771739468156244 0.878048780487805 12.4 12 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.68372308230528e-06 1.16426241085165e-05 0.771739468156244 0.878048780487805 12.4 12 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.66250728091677e-18 9.47186965186142e-17 0.771431019128203 0.877697841726619 12.4 12 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.9987714664702e-17 1.16127587689533e-15 0.770750058581684 0.876923076923077 12.4 12 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 4.45147596203031e-06 1.83607254897656e-05 0.769059817225145 0.875 12.4 12 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.45147596203031e-06 1.83607254897656e-05 0.769059817225145 0.875 12.4 12 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.35429870884655e-09 3.80958353134432e-08 0.769059817225145 0.875 12.4 12 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00042776320319604 0.00126026301893989 0.769059817225145 0.875 12.4 12 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00042776320319604 0.00126026301893989 0.769059817225145 0.875 12.4 12 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0044585518248906 0.0102155021774914 0.769059817225145 0.875 12.4 12 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0044585518248906 0.0102155021774914 0.769059817225145 0.875 12.4 12 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0044585518248906 0.0102155021774914 0.769059817225145 0.875 12.4 12 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0044585518248906 0.0102155021774914 0.769059817225145 0.875 12.4 12 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0044585518248906 0.0102155021774914 0.769059817225145 0.875 12.4 12 4 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0044585518248906 0.0102155021774914 0.769059817225145 0.875 12.4 12 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0044585518248906 0.0102155021774914 0.769059817225145 0.875 12.4 12 4 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 48%5605104 DISSOLUTION OF FIBRIN CLOT 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0516829510082659 0.0842438021589489 0.769059817225145 0.875 12.4 12 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 5.95692964326877e-28 5.29794430148216e-26 0.768567145977724 0.874439461883408 12.4 12 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.61470945065751e-23 1.97835828780217e-21 0.768459458273369 0.87431693989071 12.4 12 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.84148949045871e-09 6.01982753345586e-08 0.767315917412844 0.873015873015873 12.4 12 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.6783571142822e-27 2.24194245507269e-25 0.767062259258327 0.872727272727273 12.4 12 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.45530502012052e-14 4.99128434804501e-13 0.767062259258327 0.872727272727273 12.4 12 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.86412908393375e-11 1.84829681463919e-10 0.766504801221075 0.872093023255814 12.4 12 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 9.82169800199427e-18 3.03832092539953e-16 0.765920797563002 0.871428571428571 12.4 12 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.82169800199427e-18 3.03832092539953e-16 0.765920797563002 0.871428571428571 12.4 12 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.95198982098981e-33 5.11243774115318e-31 0.765828473455292 0.871323529411765 12.4 12 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 6.04762080230458e-13 1.12219757750195e-11 0.764665189698145 0.87 12.4 12 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.58890195061252e-09 1.98064918049549e-08 0.764283048174058 0.869565217391304 12.4 12 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.58890195061252e-09 1.98064918049549e-08 0.764283048174058 0.869565217391304 12.4 12 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.58890195061252e-09 1.98064918049549e-08 0.764283048174058 0.869565217391304 12.4 12 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.27503984930971e-06 5.87178545491172e-06 0.764283048174058 0.869565217391304 12.4 12 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.000708950303804834 0.00197811035747898 0.764283048174058 0.869565217391304 12.4 12 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000708950303804834 0.00197811035747898 0.764283048174058 0.869565217391304 12.4 12 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000708950303804834 0.00197811035747898 0.764283048174058 0.869565217391304 12.4 12 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 9.92625741493476e-13 1.75136239465817e-11 0.763511045095094 0.868686868686869 12.4 12 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 4.6177225158568e-10 3.88817700595516e-09 0.763277412584355 0.868421052631579 12.4 12 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.21270265773119e-05 4.71496142609696e-05 0.763277412584355 0.868421052631579 12.4 12 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 4.24869224229105e-09 3.08463727590825e-08 0.762597129685438 0.867647058823529 12.4 12 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.4815059343347e-11 1.51667837738006e-10 0.761735438013477 0.866666666666667 12.4 12 4 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.000117399836787514 0.000382288255717693 0.761735438013477 0.866666666666667 12.4 12 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00741023836627611 0.0159527521864008 0.761735438013477 0.866666666666667 12.4 12 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.05540281052439e-15 2.545488473519e-14 0.761274059795419 0.866141732283465 12.4 12 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.35222065671606e-10 1.2256114614694e-09 0.761020864431851 0.865853658536585 12.4 12 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 6.95783473563871e-09 4.85343079843818e-08 0.760860885271786 0.865671641791045 12.4 12 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.36917718263408e-61 6.74267826177658e-59 0.76041869568329 0.865168539325843 12.4 12 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 6.42773412988135e-08 3.89219815609411e-07 0.759749165684889 0.864406779661017 12.4 12 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.20939761816054e-10 1.91705659185515e-09 0.759565251580391 0.864197530864197 12.4 12 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00116853952621696 0.00310809672113407 0.759072027391053 0.863636363636364 12.4 12 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00116853952621696 0.00310809672113407 0.759072027391053 0.863636363636364 12.4 12 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00116853952621696 0.00310809672113407 0.759072027391053 0.863636363636364 12.4 12 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00116853952621696 0.00310809672113407 0.759072027391053 0.863636363636364 12.4 12 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 5.08925313358211e-16 1.24862193260127e-14 0.759072027391053 0.863636363636364 12.4 12 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.02033643955463e-09 1.5796366777397e-08 0.75852475123576 0.863013698630137 12.4 12 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 5.97464893509193e-07 2.94184271094665e-06 0.758288671325633 0.862745098039216 12.4 12 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 6.44545692761246e-11 6.03413500525825e-10 0.75769440120704 0.862068965517241 12.4 12 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 6.44545692761246e-11 6.03413500525825e-10 0.75769440120704 0.862068965517241 12.4 12 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.15530436422991e-24 1.39409005013599e-22 0.757550078463953 0.861904761904762 12.4 12 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 3.2910143211809e-09 2.46479651528443e-08 0.756852518539032 0.861111111111111 12.4 12 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 3.2910143211809e-09 2.46479651528443e-08 0.756852518539032 0.861111111111111 12.4 12 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 3.25673835361827e-05 0.000118829196851251 0.756852518539032 0.861111111111111 12.4 12 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 3.25673835361827e-05 0.000118829196851251 0.756852518539032 0.861111111111111 12.4 12 4 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 3.25673835361827e-05 0.000118829196851251 0.756852518539032 0.861111111111111 12.4 12 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.04856168529344e-10 9.68898232579586e-10 0.756284737204794 0.86046511627907 12.4 12 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 5.59898704905964e-06 2.28291076527561e-05 0.756284737204794 0.86046511627907 12.4 12 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 6.07232701810614e-13 1.12219757750195e-11 0.755711649502947 0.85981308411215 12.4 12 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 5.3495162556423e-09 3.80958353134432e-08 0.755133180695917 0.859154929577465 12.4 12 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.81344959531911e-18 1.32354604247295e-16 0.754974472587322 0.858974358974359 12.4 12 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.70274357615881e-10 1.52390195526666e-09 0.75484190463779 0.858823529411765 12.4 12 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.70274357615881e-10 1.52390195526666e-09 0.75484190463779 0.858823529411765 12.4 12 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.75994521650835e-10 2.36590484523577e-09 0.753364718914428 0.857142857142857 12.4 12 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.75994521650835e-10 2.36590484523577e-09 0.753364718914428 0.857142857142857 12.4 12 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 8.67663327580582e-09 5.93598516897677e-08 0.753364718914428 0.857142857142857 12.4 12 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 5.30576605984134e-05 0.000184599146776387 0.753364718914428 0.857142857142857 12.4 12 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000314470649807332 0.000956178920247509 0.753364718914428 0.857142857142857 12.4 12 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0122178409678905 0.0243160667095219 0.753364718914428 0.857142857142857 12.4 12 4 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0864923037522462 0.129829692235703 0.753364718914428 0.857142857142857 12.4 12 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.91996231717528e-08 4.69587765722518e-07 0.751339544938852 0.854838709677419 12.4 12 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 7.20959655992005e-10 5.99956485658844e-09 0.750302260707459 0.853658536585366 12.4 12 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.14872513883945e-14 2.40387628318902e-13 0.74947136119394 0.852713178294574 12.4 12 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.27872450655372e-07 7.36690272399165e-07 0.749247971816535 0.852459016393443 12.4 12 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000510828514411452 0.00148532105324614 0.748714319414956 0.851851851851852 12.4 12 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000510828514411452 0.00148532105324614 0.748714319414956 0.851851851851852 12.4 12 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 6.50260343330373e-09 4.58079439880752e-08 0.748274416759601 0.851351351351351 12.4 12 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 6.50260343330373e-09 4.58079439880752e-08 0.748274416759601 0.851351351351351 12.4 12 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.0222873170714e-13 1.96583088134136e-12 0.748176256662951 0.851239669421488 12.4 12 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.0222873170714e-13 1.96583088134136e-12 0.748176256662951 0.851239669421488 12.4 12 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.65164488541067e-08 2.26230536404971e-07 0.74774259414641 0.850746268656716 12.4 12 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.61133905094155e-20 1.23864515649661e-18 0.747321686409767 0.850267379679144 12.4 12 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 2.384041895614e-05 8.95116521756917e-05 0.747086679590141 0.85 12.4 12 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00311646895246634 0.00751650054128747 0.747086679590141 0.85 12.4 12 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00311646895246634 0.00751650054128747 0.747086679590141 0.85 12.4 12 4 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00311646895246634 0.00751650054128747 0.747086679590141 0.85 12.4 12 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00311646895246634 0.00751650054128747 0.747086679590141 0.85 12.4 12 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00311646895246634 0.00751650054128747 0.747086679590141 0.85 12.4 12 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00311646895246634 0.00751650054128747 0.747086679590141 0.85 12.4 12 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.05912315902113e-07 1.10571028501399e-06 0.747086679590141 0.85 12.4 12 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 1.16718117178475e-06 5.48151421600559e-06 0.746257504585047 0.849056603773585 12.4 12 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.000139021720498186 0.000448589361154011 0.745754974278929 0.848484848484849 12.4 12 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.000139021720498186 0.000448589361154011 0.745754974278929 0.848484848484849 12.4 12 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000139021720498186 0.000448589361154011 0.745754974278929 0.848484848484849 12.4 12 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.99831712737039e-09 2.26947088949365e-08 0.745417833693812 0.848101265822785 12.4 12 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 6.66050497551397e-06 2.67737248027016e-05 0.745175971969706 0.847826086956522 12.4 12 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.67648451649288e-08 1.0943291132887e-07 0.744645219852919 0.847222222222222 12.4 12 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 3.83466769912205e-05 0.000136078108125952 0.743706196877064 0.846153846153846 12.4 12 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.04898317919959e-27 4.78205725777835e-25 0.743706196877064 0.846153846153846 12.4 12 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 9.40360983797364e-08 5.55242190847987e-07 0.743706196877064 0.846153846153846 12.4 12 4 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.000825245249038245 0.00229808999878948 0.743706196877064 0.846153846153846 12.4 12 4 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0199620442275769 0.0378242196216271 0.743706196877064 0.846153846153846 12.4 12 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0199620442275769 0.0378242196216271 0.743706196877064 0.846153846153846 12.4 12 4 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0199620442275769 0.0378242196216271 0.743706196877064 0.846153846153846 12.4 12 4 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0199620442275769 0.0378242196216271 0.743706196877064 0.846153846153846 12.4 12 4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0199620442275769 0.0378242196216271 0.743706196877064 0.846153846153846 12.4 12 4 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0199620442275769 0.0378242196216271 0.743706196877064 0.846153846153846 12.4 12 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0199620442275769 0.0378242196216271 0.743706196877064 0.846153846153846 12.4 12 4 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0199620442275769 0.0378242196216271 0.743706196877064 0.846153846153846 12.4 12 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 5.29526922300956e-07 2.64391863310267e-06 0.742540513182899 0.844827586206897 12.4 12 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 5.29526922300956e-07 2.64391863310267e-06 0.742540513182899 0.844827586206897 12.4 12 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 5.9488783952022e-12 9.30247687513487e-11 0.741845380704727 0.844036697247706 12.4 12 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 7.29260466516424e-17 1.99564931510168e-15 0.74159339518139 0.84375 12.4 12 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 2.19878390687675e-09 1.70976475381728e-08 0.741262474433875 0.843373493975904 12.4 12 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 6.31354144528175e-10 5.28480557449173e-09 0.740667560730477 0.842696629213483 12.4 12 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.22300475673397e-08 8.28731318491637e-08 0.740147794021193 0.842105263157895 12.4 12 4 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00503656137646753 0.0114306648145348 0.740147794021193 0.842105263157895 12.4 12 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.8478433085747e-16 4.86940931129962e-15 0.73985501403938 0.841772151898734 12.4 12 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.39638842998196e-07 1.26768057095328e-06 0.739413520416013 0.841269841269841 12.4 12 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.70629572130857e-05 6.5979859006035e-05 0.739096447722867 0.840909090909091 12.4 12 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 6.81713667937788e-08 4.1105023282859e-07 0.738806946568256 0.840579710144927 12.4 12 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 4.77753039886776e-06 1.96486293571931e-05 0.73829742453614 0.84 12.4 12 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.001325322381865 0.00351198091134803 0.73829742453614 0.84 12.4 12 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 8.8022285401078e-15 1.98818590675768e-13 0.737559864671468 0.839160839160839 12.4 12 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 3.80971153570183e-07 1.96420996931294e-06 0.737163327109817 0.838709677419355 12.4 12 4 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 9.79599550741973e-05 0.000325693962781735 0.736397045065004 0.837837837837838 12.4 12 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 2.71546101761679e-05 0.000101686869159703 0.735844609172232 0.837209302325581 12.4 12 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 7.25370937374999e-10 6.0011793249106e-09 0.73562243386753 0.83695652173913 12.4 12 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.59080141994708e-06 3.03418832038896e-05 0.73542746370218 0.836734693877551 12.4 12 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 2.13564894038804e-06 9.49696388178808e-06 0.73510133178923 0.836363636363636 12.4 12 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.13564894038804e-06 9.49696388178808e-06 0.73510133178923 0.836363636363636 12.4 12 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.13564894038804e-06 9.49696388178808e-06 0.73510133178923 0.836363636363636 12.4 12 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 2.13564894038804e-06 9.49696388178808e-06 0.73510133178923 0.836363636363636 12.4 12 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.13564894038804e-06 9.49696388178808e-06 0.73510133178923 0.836363636363636 12.4 12 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 2.13564894038804e-06 9.49696388178808e-06 0.73510133178923 0.836363636363636 12.4 12 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 2.13564894038804e-06 9.49696388178808e-06 0.73510133178923 0.836363636363636 12.4 12 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.30523644630007e-17 3.9518116235851e-16 0.73492076157754 0.836158192090395 12.4 12 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 6.03915628660501e-07 2.95316817726424e-06 0.734839356973909 0.836065573770492 12.4 12 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 6.03915628660501e-07 2.95316817726424e-06 0.734839356973909 0.836065573770492 12.4 12 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.99585509294823e-09 2.91594963962324e-08 0.734161304510727 0.835294117647059 12.4 12 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.99585509294823e-09 2.91594963962324e-08 0.734161304510727 0.835294117647059 12.4 12 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.99585509294823e-09 2.91594963962324e-08 0.734161304510727 0.835294117647059 12.4 12 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.99585509294823e-09 2.91594963962324e-08 0.734161304510727 0.835294117647059 12.4 12 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.99585509294823e-09 2.91594963962324e-08 0.734161304510727 0.835294117647059 12.4 12 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.30583738744243e-11 4.08480440155372e-10 0.732437921166805 0.833333333333333 12.4 12 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.37785668887558e-06 1.41790267500589e-05 0.732437921166805 0.833333333333333 12.4 12 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 3.37785668887558e-06 1.41790267500589e-05 0.732437921166805 0.833333333333333 12.4 12 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0021148858068488 0.00529838468863704 0.732437921166805 0.833333333333333 12.4 12 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0021148858068488 0.00529838468863704 0.732437921166805 0.833333333333333 12.4 12 4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0322763458416251 0.0571259205629757 0.732437921166805 0.833333333333333 12.4 12 4 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 48%5605140 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_223937.1 FGFR2B LIGAND BINDING AND ACTIVATION 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 KLOTHO-MEDIATED LIGAND BINDING%REACTOME%REACT_222862.1 KLOTHO-MEDIATED LIGAND BINDING 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.142556988375163 0.204494550864775 0.732437921166805 0.833333333333333 12.4 12 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.24179437324818e-11 1.28048796603779e-10 0.732437921166805 0.833333333333333 12.4 12 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 9.54481279148428e-07 4.49743993453051e-06 0.732437921166805 0.833333333333333 12.4 12 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0080754566331257 0.0172284479594271 0.732437921166805 0.833333333333333 12.4 12 4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0080754566331257 0.0172284479594271 0.732437921166805 0.833333333333333 12.4 12 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0080754566331257 0.0172284479594271 0.732437921166805 0.833333333333333 12.4 12 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0080754566331257 0.0172284479594271 0.732437921166805 0.833333333333333 12.4 12 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0080754566331257 0.0172284479594271 0.732437921166805 0.833333333333333 12.4 12 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.50390717367079e-06 6.90341905849527e-06 0.72995508075607 0.830508474576271 12.4 12 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 5.32451782379647e-06 2.18351264070962e-05 0.729674004483157 0.830188679245283 12.4 12 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.69348625189599e-10 3.12847079550476e-09 0.729508169482138 0.83 12.4 12 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.44128849049998e-08 1.55087210802744e-07 0.727012455084088 0.827160493827161 12.4 12 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 8.36353563711993e-06 3.33370061950187e-05 0.726803783311676 0.826923076923077 12.4 12 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 4.55370048308077e-17 1.29598315748479e-15 0.726068895765355 0.826086956521739 12.4 12 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.97744089650947e-05 0.000110913570568926 0.726068895765355 0.826086956521739 12.4 12 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 2.97744089650947e-05 0.000110913570568926 0.726068895765355 0.826086956521739 12.4 12 4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00335158833267452 0.00793924224991246 0.726068895765355 0.826086956521739 12.4 12 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000106733322013744 0.000353212830757112 0.725113541955137 0.825 12.4 12 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.012834837237132 0.025366629706165 0.723821004447196 0.823529411764706 12.4 12 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.012834837237132 0.025366629706165 0.723821004447196 0.823529411764706 12.4 12 4 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.012834837237132 0.025366629706165 0.723821004447196 0.823529411764706 12.4 12 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.012834837237132 0.025366629706165 0.723821004447196 0.823529411764706 12.4 12 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.07554636590833e-11 1.28048796603779e-10 0.722987109280782 0.82258064516129 12.4 12 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.07554636590833e-11 1.28048796603779e-10 0.722987109280782 0.82258064516129 12.4 12 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.07554636590833e-11 1.28048796603779e-10 0.722987109280782 0.82258064516129 12.4 12 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 4.65826803854525e-05 0.000162867700708843 0.722672082217914 0.822222222222222 12.4 12 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.28260999751389e-10 1.1699705297835e-09 0.721974522292994 0.821428571428571 12.4 12 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 5.76867290113187e-06 2.34537758237447e-05 0.721974522292994 0.821428571428571 12.4 12 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0014140746915904 0.00371259831389878 0.721974522292994 0.821428571428571 12.4 12 4 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0014140746915904 0.00371259831389878 0.721974522292994 0.821428571428571 12.4 12 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0014140746915904 0.00371259831389878 0.721974522292994 0.821428571428571 12.4 12 4 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0014140746915904 0.00371259831389878 0.721974522292994 0.821428571428571 12.4 12 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.98975767468846e-10 1.74779331548251e-09 0.720560549472208 0.81981981981982 12.4 12 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.22587817063078e-07 1.68765611647338e-06 0.720230622480692 0.819444444444444 12.4 12 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.26833265498254e-18 8.27650607189785e-17 0.719881842518231 0.819047619047619 12.4 12 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.64657969206187e-73 1.25536096726801e-70 0.719843965961222 0.819004524886878 12.4 12 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.84028153313463e-08 1.18494145776044e-07 0.719120868054681 0.818181818181818 12.4 12 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00060350622932206 0.00171757872865058 0.719120868054681 0.818181818181818 12.4 12 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00060350622932206 0.00171757872865058 0.719120868054681 0.818181818181818 12.4 12 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00527175628269112 0.0119264057079006 0.719120868054681 0.818181818181818 12.4 12 4 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0515605176034006 0.0842438021589489 0.719120868054681 0.818181818181818 12.4 12 4 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0515605176034006 0.0842438021589489 0.719120868054681 0.818181818181818 12.4 12 4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0515605176034006 0.0842438021589489 0.719120868054681 0.818181818181818 12.4 12 4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0515605176034006 0.0842438021589489 0.719120868054681 0.818181818181818 12.4 12 4 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0515605176034006 0.0842438021589489 0.719120868054681 0.818181818181818 12.4 12 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 3.16897423605312e-05 0.000117424437215449 0.717490208489932 0.816326530612245 12.4 12 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000259762110158442 0.000800089789513989 0.71701817545803 0.815789473684211 12.4 12 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 9.86163151583929e-08 5.79880233348732e-07 0.716161522918654 0.814814814814815 12.4 12 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00220867888139614 0.00545651050039359 0.716161522918654 0.814814814814815 12.4 12 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00220867888139614 0.00545651050039359 0.716161522918654 0.814814814814815 12.4 12 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00220867888139614 0.00545651050039359 0.716161522918654 0.814814814814815 12.4 12 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00220867888139614 0.00545651050039359 0.716161522918654 0.814814814814815 12.4 12 4 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.00220867888139614 0.00545651050039359 0.716161522918654 0.814814814814815 12.4 12 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000112538562628436 0.000368143389931641 0.71540448113967 0.813953488372093 12.4 12 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 2.69179433007866e-06 1.16426241085165e-05 0.714126973137635 0.8125 12.4 12 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 2.69179433007866e-06 1.16426241085165e-05 0.714126973137635 0.8125 12.4 12 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 4.90080989831098e-05 0.000170927756992562 0.714126973137635 0.8125 12.4 12 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000937881956666681 0.00259146800842075 0.714126973137635 0.8125 12.4 12 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0202008800456133 0.0380236141599309 0.714126973137635 0.8125 12.4 12 4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0202008800456133 0.0380236141599309 0.714126973137635 0.8125 12.4 12 4 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0202008800456133 0.0380236141599309 0.714126973137635 0.8125 12.4 12 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0202008800456133 0.0380236141599309 0.714126973137635 0.8125 12.4 12 4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0202008800456133 0.0380236141599309 0.714126973137635 0.8125 12.4 12 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.33799950798748e-08 8.93884178340934e-08 0.712392251745398 0.810526315789474 12.4 12 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.33340033980023e-07 1.23896592669243e-06 0.712040915767223 0.810126582278481 12.4 12 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000173707019125042 0.000545662446390584 0.711511123419182 0.80952380952381 12.4 12 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 9.5671394704725e-77 6.80701973324118e-74 0.710882691054389 0.808808808808809 12.4 12 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 8.07119815285195e-07 3.82843832383611e-06 0.710364449569997 0.808219178082192 12.4 12 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00342564633973735 0.00793924224991246 0.709901369746288 0.807692307692308 12.4 12 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 7.24111499325303e-18 2.39630386869746e-16 0.70944659628713 0.807174887892377 12.4 12 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.04249202464095e-08 4.22846673040678e-07 0.709133078220589 0.806818181818182 12.4 12 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00144857457995125 0.00376841248129913 0.708810891451747 0.806451612903226 12.4 12 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.23398289423235e-06 5.77617650819944e-06 0.708023323794578 0.805555555555556 12.4 12 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.71342070908618e-28 1.62546511268642e-26 0.707370527073396 0.804812834224599 12.4 12 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.07419425076866e-07 6.2904461680815e-07 0.70718144112657 0.804597701149425 12.4 12 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.61364013171154e-36 2.55134434158392e-34 0.705641411855824 0.802845528455285 12.4 12 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 8.31609694788029e-07 3.9314969956258e-06 0.705453366176449 0.802631578947368 12.4 12 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.63417522061855e-07 8.89151090933197e-07 0.705184417123389 0.802325581395349 12.4 12 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.28548178366319e-19 1.29867793837576e-17 0.704535524169975 0.801587301587302 12.4 12 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.28548178366319e-19 1.29867793837576e-17 0.704535524169975 0.801587301587302 12.4 12 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.28548178366319e-19 1.29867793837576e-17 0.704535524169975 0.801587301587302 12.4 12 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.89548517869938e-08 2.97704077320052e-07 0.703140404320133 0.8 12.4 12 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.89548517869938e-08 2.97704077320052e-07 0.703140404320133 0.8 12.4 12 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 7.68214564054204e-05 0.000259044863660932 0.703140404320133 0.8 12.4 12 4 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0127169310724722 0.0252740124526926 0.703140404320133 0.8 12.4 12 4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0812096511920294 0.124527299187778 0.703140404320133 0.8 12.4 12 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 2.85732810377859e-06 1.23211451262937e-05 0.703140404320133 0.8 12.4 12 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.000176504521008381 0.000552013040428409 0.703140404320133 0.8 12.4 12 4 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00222272989136759 0.00548170647385802 0.703140404320133 0.8 12.4 12 4 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0314482513743482 0.0563612867829944 0.703140404320133 0.8 12.4 12 4 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0314482513743482 0.0563612867829944 0.703140404320133 0.8 12.4 12 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 9.39844842343267e-13 1.6929103932335e-11 0.702068543947694 0.798780487804878 12.4 12 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000116549689811165 0.000380390386700202 0.699552953277683 0.795918367346939 12.4 12 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.000619524326818563 0.0017479784306997 0.69863309403603 0.794871794871795 12.4 12 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00144207348322332 0.00375837100114796 0.697970254288367 0.794117647058823 12.4 12 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00144207348322332 0.00375837100114796 0.697970254288367 0.794117647058823 12.4 12 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00144207348322332 0.00375837100114796 0.697970254288367 0.794117647058823 12.4 12 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00144207348322332 0.00375837100114796 0.697970254288367 0.794117647058823 12.4 12 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.07649448868889e-11 1.28048796603779e-10 0.697469917188519 0.793548387096774 12.4 12 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.07649448868889e-11 1.28048796603779e-10 0.697469917188519 0.793548387096774 12.4 12 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 5.90453344456056e-53 1.20030729880138e-50 0.696613172653909 0.792573623559539 12.4 12 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000176001434771045 0.000551652074183253 0.695816025108465 0.791666666666667 12.4 12 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.99564844458145e-09 1.5689545506295e-08 0.694634673622712 0.790322580645161 12.4 12 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0194713138455939 0.0373418862564421 0.693888556894868 0.789473684210526 12.4 12 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00060814719633199 0.00172733225624835 0.690584325671559 0.785714285714286 12.4 12 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00512222757735052 0.011606576182436 0.690584325671559 0.785714285714286 12.4 12 4 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0483574561797606 0.0812428100871302 0.690584325671559 0.785714285714286 12.4 12 4 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0483574561797606 0.0812428100871302 0.690584325671559 0.785714285714286 12.4 12 4 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0483574561797606 0.0812428100871302 0.690584325671559 0.785714285714286 12.4 12 4 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0483574561797606 0.0812428100871302 0.690584325671559 0.785714285714286 12.4 12 4 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0483574561797606 0.0812428100871302 0.690584325671559 0.785714285714286 12.4 12 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 6.60898877432153e-09 4.63280346101455e-08 0.690065479446411 0.785123966942149 12.4 12 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00140591288940309 0.00371259831389878 0.688887558286617 0.783783783783784 12.4 12 4 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0121843609027509 0.0243160667095219 0.687854743356652 0.782608695652174 12.4 12 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.37507856169346e-13 1.1630431786269e-11 0.68666055109388 0.78125 12.4 12 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00327247680596753 0.00787941538898782 0.68666055109388 0.78125 12.4 12 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.42291498355508e-08 9.46171972709754e-08 0.68440920502472 0.778688524590164 12.4 12 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00768503244393164 0.0165193371113515 0.683608726422351 0.777777777777778 12.4 12 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0294926693511538 0.0536676067604756 0.683608726422351 0.777777777777778 12.4 12 4 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.125780604938694 0.1847118687593 0.683608726422351 0.777777777777778 12.4 12 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.99293004599481e-12 3.41679452463929e-11 0.682082814086587 0.776041666666667 12.4 12 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00487697667336649 0.0110861626297133 0.680458455793677 0.774193548387097 12.4 12 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.65874452490133e-09 2.0232050582538e-08 0.679453050273887 0.773049645390071 12.4 12 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.33791902009846e-19 5.76926898666699e-18 0.679414807855343 0.773006134969325 12.4 12 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.515663891991e-07 8.29534507039689e-07 0.67916970871831 0.772727272727273 12.4 12 4 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0182638353285535 0.0351683865663486 0.67916970871831 0.772727272727273 12.4 12 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 3.04745412345734e-05 0.000113225253725321 0.678028247022985 0.771428571428571 12.4 12 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.36317034277071e-07 1.75303714203763e-06 0.678028247022985 0.771428571428571 12.4 12 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.29931415546439e-08 8.7213398265369e-08 0.677644855308525 0.770992366412214 12.4 12 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.29931415546439e-08 8.7213398265369e-08 0.677644855308525 0.770992366412214 12.4 12 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000562138115594831 0.00160950208952001 0.677505077079295 0.770833333333333 12.4 12 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 7.46192069980204e-07 3.55127530294927e-06 0.676772639158128 0.77 12.4 12 4 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0114314500636063 0.0236438276751625 0.676096542615512 0.769230769230769 12.4 12 4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0733240178884523 0.116973181003663 0.676096542615512 0.769230769230769 12.4 12 4 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0733240178884523 0.116973181003663 0.676096542615512 0.769230769230769 12.4 12 4 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.0733240178884523 0.116973181003663 0.676096542615512 0.769230769230769 12.4 12 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0733240178884523 0.116973181003663 0.676096542615512 0.769230769230769 12.4 12 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 3.67159976796935e-06 1.53216612018193e-05 0.673842887473461 0.766666666666667 12.4 12 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00721180711125835 0.0157398796308599 0.673842887473461 0.766666666666667 12.4 12 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.63429533141781e-84 2.32560225660754e-81 0.673521352427371 0.76630083925113 12.4 12 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 9.97334090443548e-05 0.000330817345151788 0.672927340072002 0.765625 12.4 12 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0045776191912977 0.0104390258160523 0.672119504129539 0.764705882352941 12.4 12 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0045776191912977 0.0104390258160523 0.672119504129539 0.764705882352941 12.4 12 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0441405191731779 0.075044156252607 0.672119504129539 0.764705882352941 12.4 12 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 9.63188800039405e-31 1.14218138538006e-28 0.671123503247763 0.763572679509632 12.4 12 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.71674698928205e-24 2.9182308546732e-22 0.6700328964934 0.762331838565022 12.4 12 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00186974237996718 0.00473424093717668 0.669657527923936 0.761904761904762 12.4 12 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0168477996069016 0.0330681639180978 0.667983384104126 0.76 12.4 12 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0168477996069016 0.0330681639180978 0.667983384104126 0.76 12.4 12 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0168477996069016 0.0330681639180978 0.667983384104126 0.76 12.4 12 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.000499844594922781 0.00146958441854363 0.6673323281742 0.759259259259259 12.4 12 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0105762779625198 0.0219069047171261 0.666771073062195 0.758620689655172 12.4 12 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00668693887478266 0.0146392523366396 0.665852655606186 0.757575757575758 12.4 12 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00668693887478266 0.0146392523366396 0.665852655606186 0.757575757575758 12.4 12 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 8.85461941753735e-05 0.000297172722432916 0.665472168374412 0.757142857142857 12.4 12 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 3.5149114213928e-05 0.000126947181539136 0.661906862091483 0.753086419753086 12.4 12 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 4.34912578519741e-14 8.59556387824432e-13 0.65998738311637 0.750902527075812 12.4 12 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00160994021766597 0.004135279656568 0.659194129050125 0.75 12.4 12 4 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.015373447043675 0.0303417685757969 0.659194129050125 0.75 12.4 12 4 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0397344621649588 0.0696331769220891 0.659194129050125 0.75 12.4 12 4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.109413032888727 0.162520611482942 0.659194129050125 0.75 12.4 12 4 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.109413032888727 0.162520611482942 0.659194129050125 0.75 12.4 12 4 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.109413032888727 0.162520611482942 0.659194129050125 0.75 12.4 12 4 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.109413032888727 0.162520611482942 0.659194129050125 0.75 12.4 12 4 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.065190365360553 0.104820214585386 0.659194129050125 0.75 12.4 12 4 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.065190365360553 0.104820214585386 0.659194129050125 0.75 12.4 12 4 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.190920361984188 0.259483930375835 0.659194129050125 0.75 12.4 12 4 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.190920361984188 0.259483930375835 0.659194129050125 0.75 12.4 12 4 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.190920361984188 0.259483930375835 0.659194129050125 0.75 12.4 12 4 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.190920361984188 0.259483930375835 0.659194129050125 0.75 12.4 12 4 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.190920361984188 0.259483930375835 0.659194129050125 0.75 12.4 12 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.6438041461399e-06 1.52503920586973e-05 0.657140564785171 0.747663551401869 12.4 12 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.37062231496858e-29 3.68953504169253e-27 0.654751659543825 0.744945567651633 12.4 12 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00561224342869771 0.0126564538811994 0.653559991194995 0.743589743589744 12.4 12 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00561224342869771 0.0126564538811994 0.653559991194995 0.743589743589744 12.4 12 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.91816360501906e-11 2.78694416774639e-10 0.65259275722845 0.742489270386266 12.4 12 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000368071648197413 0.00108891051015576 0.652535602494063 0.742424242424242 12.4 12 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000567453163039735 0.00162145753213964 0.652106020135607 0.741935483870968 12.4 12 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0221355004055342 0.0413370302848755 0.651055929926049 0.740740740740741 12.4 12 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00210283445916685 0.00528680818974279 0.650404873996123 0.74 12.4 12 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0354890128683277 0.0625785195930983 0.649640590947949 0.739130434782609 12.4 12 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0575524647667216 0.0931708274892433 0.647629319768543 0.736842105263158 12.4 12 4 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0575524647667216 0.0931708274892433 0.647629319768543 0.736842105263158 12.4 12 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0198285728034884 0.0378242196216271 0.644545370626788 0.733333333333333 12.4 12 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00719594149344118 0.0157293774887355 0.643116223463536 0.731707317073171 12.4 12 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0315493197958457 0.0564712982006143 0.642291715484737 0.730769230769231 12.4 12 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.08076608099354e-19 4.80603166641814e-18 0.640994156463556 0.729292929292929 12.4 12 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00242468290081572 0.00596941828349614 0.639218549381939 0.727272727272727 12.4 12 4 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.160274007428373 0.219509059259456 0.639218549381939 0.727272727272727 12.4 12 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00218405043798395 0.00544291378853093 0.636463297013913 0.724137931034483 12.4 12 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00218405043798395 0.00544291378853093 0.636463297013913 0.724137931034483 12.4 12 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00218405043798395 0.00544291378853093 0.636463297013913 0.724137931034483 12.4 12 4 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.0822249287104401 0.125812982317157 0.634779531677898 0.722222222222222 12.4 12 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0822249287104401 0.125812982317157 0.634779531677898 0.722222222222222 12.4 12 4 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0444780503628485 0.07543774215296 0.63282636388812 0.72 12.4 12 4 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0444780503628485 0.07543774215296 0.63282636388812 0.72 12.4 12 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 9.22932502918514e-10 7.54789052674164e-09 0.630758303875413 0.717647058823529 12.4 12 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.00464200202378651 0.0105689102077571 0.630173003871817 0.716981132075472 12.4 12 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 6.73032018792756e-07 3.27059321173432e-06 0.628533937001282 0.715116279069767 12.4 12 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0713388534794944 0.114447788614792 0.62780393242869 0.714285714285714 12.4 12 4 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.135740422160182 0.198518623570338 0.62780393242869 0.714285714285714 12.4 12 4 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.135740422160182 0.198518623570338 0.62780393242869 0.714285714285714 12.4 12 4 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.282718699932454 0.356378847594919 0.62780393242869 0.714285714285714 12.4 12 4 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.282718699932454 0.356378847594919 0.62780393242869 0.714285714285714 12.4 12 4 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_225157.1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE 0.282718699932454 0.356378847594919 0.62780393242869 0.714285714285714 12.4 12 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.282718699932454 0.356378847594919 0.62780393242869 0.714285714285714 12.4 12 4 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_216831.1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE 0.282718699932454 0.356378847594919 0.62780393242869 0.714285714285714 12.4 12 4 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.282718699932454 0.356378847594919 0.62780393242869 0.714285714285714 12.4 12 4 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.282718699932454 0.356378847594919 0.62780393242869 0.714285714285714 12.4 12 4 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.282718699932454 0.356378847594919 0.62780393242869 0.714285714285714 12.4 12 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 3.28433293947702e-05 0.000119529559408588 0.626774745654217 0.713114754098361 12.4 12 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00113340718828593 0.00303736050646117 0.624499701205381 0.710526315789474 12.4 12 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0342608861404217 0.0605630322705839 0.623753584477537 0.709677419354839 12.4 12 4 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0619719602748897 0.100097729252177 0.622572232991784 0.708333333333333 12.4 12 4 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0619719602748897 0.100097729252177 0.622572232991784 0.708333333333333 12.4 12 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 5.56162582805947e-06 2.27419354980708e-05 0.621405930569544 0.707006369426752 12.4 12 4 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.115709996210254 0.17151596313249 0.620418003811882 0.705882352941177 12.4 12 4 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.115709996210254 0.17151596313249 0.620418003811882 0.705882352941177 12.4 12 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00446524410007004 0.0102155021774914 0.619570438232904 0.704918032786885 12.4 12 4 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0539071408478354 0.0875683349617235 0.618503133429747 0.703703703703704 12.4 12 4 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0991278041708352 0.148015598462853 0.615247853780116 0.7 12.4 12 4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0991278041708352 0.148015598462853 0.615247853780116 0.7 12.4 12 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.229779497014246 0.302940369657204 0.615247853780116 0.7 12.4 12 4 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.229779497014246 0.302940369657204 0.615247853780116 0.7 12.4 12 4 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.229779497014246 0.302940369657204 0.615247853780116 0.7 12.4 12 4 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.229779497014246 0.302940369657204 0.615247853780116 0.7 12.4 12 4 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.229779497014246 0.302940369657204 0.615247853780116 0.7 12.4 12 4 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.229779497014246 0.302940369657204 0.615247853780116 0.7 12.4 12 4 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.229779497014246 0.302940369657204 0.615247853780116 0.7 12.4 12 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0469533830642191 0.0794466873964136 0.615247853780116 0.7 12.4 12 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.0469533830642191 0.0794466873964136 0.615247853780116 0.7 12.4 12 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0409473421278167 0.0716704401572978 0.612584443157691 0.696969696969697 12.4 12 4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0852588670747617 0.129829692235703 0.611426438539246 0.695652173913043 12.4 12 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0852588670747617 0.129829692235703 0.611426438539246 0.695652173913043 12.4 12 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.000904955967886165 0.00251514129355862 0.610621930067484 0.694736842105263 12.4 12 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0157379584991015 0.031018164742689 0.609866677216442 0.693877551020408 12.4 12 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000159977437985856 0.000504762514975328 0.609019247836336 0.692913385826772 12.4 12 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0735676941386051 0.117162922435981 0.608486888353961 0.692307692307692 12.4 12 4 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.190613316639345 0.259483930375835 0.608486888353961 0.692307692307692 12.4 12 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00119728383060102 0.00317860987116652 0.607767636712881 0.691489361702128 12.4 12 4 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0636508958734584 0.102576698559379 0.606155520965632 0.689655172413793 12.4 12 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0209794762534018 0.0393849534414127 0.604261284962614 0.6875 12.4 12 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0551967465695269 0.0895609696333372 0.604261284962614 0.6875 12.4 12 4 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.160126058269644 0.219509059259456 0.604261284962614 0.6875 12.4 12 4 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.160126058269644 0.219509059259456 0.604261284962614 0.6875 12.4 12 4 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.160126058269644 0.219509059259456 0.604261284962614 0.6875 12.4 12 4 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.160126058269644 0.219509059259456 0.604261284962614 0.6875 12.4 12 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.13568193392183 0.198518623570338 0.601370082642219 0.684210526315789 12.4 12 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0363856849371105 0.0639039767921981 0.600241808565967 0.682926829268293 12.4 12 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0363856849371105 0.0639039767921981 0.600241808565967 0.682926829268293 12.4 12 4 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0852919890384372 0.129829692235703 0.596413735807256 0.678571428571429 12.4 12 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0736076266041934 0.117162922435981 0.595401148819467 0.67741935483871 12.4 12 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 3.17363716681179e-06 1.36437634089824e-05 0.5930099795471 0.674698795180723 12.4 12 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0364203268998402 0.0639039767921981 0.592319362334895 0.673913043478261 12.4 12 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0364203268998402 0.0639039767921981 0.592319362334895 0.673913043478261 12.4 12 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0243035778088973 0.0443953674224145 0.591277158178294 0.672727272727273 12.4 12 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.018651577250503 0.0358664789560348 0.590753208547653 0.672131147540984 12.4 12 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 5.64714961252585e-05 0.000195045968413211 0.588924704126 0.67005076142132 12.4 12 4 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0211098496497103 0.0395774915040023 0.585950336933444 0.666666666666667 12.4 12 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.041299118618971 0.07219735355626 0.585950336933444 0.666666666666667 12.4 12 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0473989289568545 0.0801053158023799 0.585950336933444 0.666666666666667 12.4 12 4 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.131832680674505 0.1933999016493 0.585950336933444 0.666666666666667 12.4 12 4 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.18268013120988 0.24971549155779 0.585950336933444 0.666666666666667 12.4 12 4 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.261995956507665 0.342665667380889 0.585950336933444 0.666666666666667 12.4 12 4 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.261995956507665 0.342665667380889 0.585950336933444 0.666666666666667 12.4 12 4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.261995956507665 0.342665667380889 0.585950336933444 0.666666666666667 12.4 12 4 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.321199876075174 0.40093633653945 0.585950336933444 0.666666666666667 12.4 12 4 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.321199876075174 0.40093633653945 0.585950336933444 0.666666666666667 12.4 12 4 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0836955554529473 0.12792564490821 0.585950336933444 0.666666666666667 12.4 12 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0970459214919368 0.145211720592036 0.585950336933444 0.666666666666667 12.4 12 4 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.217505727691257 0.294772048099675 0.585950336933444 0.666666666666667 12.4 12 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.217505727691257 0.294772048099675 0.585950336933444 0.666666666666667 12.4 12 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.000165362331048615 0.000520598666111017 0.584366687374165 0.664864864864865 12.4 12 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0104815723549612 0.0217423869695478 0.576499525047421 0.655913978494624 12.4 12 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0293204254545034 0.0534224909369505 0.573212286130543 0.652173913043478 12.4 12 4 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.203568174887964 0.276409840520585 0.571301578510108 0.65 12.4 12 4 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0498248230340535 0.083609343369644 0.570530591224669 0.649122807017544 12.4 12 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.104016965232666 0.155153188182478 0.570113841340648 0.648648648648649 12.4 12 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0186814807935494 0.0358755022526597 0.569304020543289 0.647727272727273 12.4 12 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0212128228377823 0.0396660274614509 0.568716503494225 0.647058823529412 12.4 12 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0212128228377823 0.0396660274614509 0.568716503494225 0.647058823529412 12.4 12 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.000127318101472129 0.000413638489485936 0.568716503494225 0.647058823529412 12.4 12 4 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.28938452670184 0.363134198850722 0.565023539185821 0.642857142857143 12.4 12 4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.28938452670184 0.363134198850722 0.565023539185821 0.642857142857143 12.4 12 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0715821044613252 0.114708710189714 0.563839003464258 0.641509433962264 12.4 12 4 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.351414103789522 0.436354511075472 0.559316230709197 0.636363636363636 12.4 12 4 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.351414103789522 0.436354511075472 0.559316230709197 0.636363636363636 12.4 12 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.351414103789522 0.436354511075472 0.559316230709197 0.636363636363636 12.4 12 4 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.351414103789522 0.436354511075472 0.559316230709197 0.636363636363636 12.4 12 4 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.351414103789522 0.436354511075472 0.559316230709197 0.636363636363636 12.4 12 4 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.351414103789522 0.436354511075472 0.559316230709197 0.636363636363636 12.4 12 4 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.177129952110012 0.242361463319757 0.556652820086772 0.633333333333333 12.4 12 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00632404115899136 0.0141051889800074 0.555394644516669 0.631901840490798 12.4 12 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00856342790125465 0.018187698363411 0.552783336729664 0.628930817610063 12.4 12 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00856342790125465 0.018187698363411 0.552783336729664 0.628930817610063 12.4 12 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0345959553804071 0.0610794596852596 0.552726348756805 0.628865979381443 12.4 12 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00817803436419853 0.017421172006369 0.552008091806202 0.628048780487805 12.4 12 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00917362533483283 0.0194546480647796 0.551375627611284 0.627329192546584 12.4 12 4 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.313138510060612 0.391905100981751 0.549328440875104 0.625 12.4 12 4 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.435715929846232 0.523081129693589 0.549328440875104 0.625 12.4 12 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0117314588904924 0.0242291233688979 0.547972074354425 0.623456790123457 12.4 12 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.221722509248647 0.30020088550031 0.545539968869069 0.620689655172414 12.4 12 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0537661091813785 0.0874390552744018 0.54087723409241 0.615384615384615 12.4 12 4 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.376208180296976 0.457168437713576 0.54087723409241 0.615384615384615 12.4 12 4 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.376208180296976 0.457168437713576 0.54087723409241 0.615384615384615 12.4 12 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0258968764314165 0.0472451989255201 0.538696277503328 0.612903225806452 12.4 12 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.236455788033005 0.310689368763588 0.538696277503328 0.612903225806452 12.4 12 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.250491460033946 0.328524744357884 0.532682124484949 0.606060606060606 12.4 12 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.250491460033946 0.328524744357884 0.532682124484949 0.606060606060606 12.4 12 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0630784869865918 0.101769486374059 0.5273553032401 0.6 12.4 12 4 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.317658221581064 0.397212345614986 0.5273553032401 0.6 12.4 12 4 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.352768911212967 0.437654891592024 0.5273553032401 0.6 12.4 12 4 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.458330444666566 0.54761059845552 0.5273553032401 0.6 12.4 12 4 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.458330444666566 0.54761059845552 0.5273553032401 0.6 12.4 12 4 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.458330444666566 0.54761059845552 0.5273553032401 0.6 12.4 12 4 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.458330444666566 0.54761059845552 0.5273553032401 0.6 12.4 12 4 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.458330444666566 0.54761059845552 0.5273553032401 0.6 12.4 12 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0658278090414761 0.105725702331852 0.526117379993057 0.598591549295775 12.4 12 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0962207838605434 0.14412860571953 0.519656685674551 0.591240875912409 12.4 12 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0962207838605434 0.14412860571953 0.519656685674551 0.591240875912409 12.4 12 4 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.369645515133577 0.449961991475688 0.519365071372825 0.590909090909091 12.4 12 4 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.288912105031601 0.363134198850722 0.518340682671893 0.58974358974359 12.4 12 4 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.415399945320733 0.500520001855549 0.517015003176568 0.588235294117647 12.4 12 4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.476599509984123 0.568007623708046 0.512706544816764 0.583333333333333 12.4 12 4 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.476599509984123 0.568007623708046 0.512706544816764 0.583333333333333 12.4 12 4 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.476599509984123 0.568007623708046 0.512706544816764 0.583333333333333 12.4 12 4 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.31188671515172 0.390682038433889 0.51100320081405 0.581395348837209 12.4 12 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.145979534202391 0.209193229778452 0.510552315636861 0.580882352941177 12.4 12 4 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.431458986989431 0.518990818669451 0.50885160838957 0.578947368421053 12.4 12 4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.431458986989431 0.518990818669451 0.50885160838957 0.578947368421053 12.4 12 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.412180541885683 0.497061789070616 0.502243145942952 0.571428571428571 12.4 12 4 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.491973051757157 0.585349207901701 0.502243145942952 0.571428571428571 12.4 12 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.290459440048542 0.364161923514604 0.500653768898829 0.569620253164557 12.4 12 4 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.435634555718528 0.523081129693589 0.494395596787593 0.5625 12.4 12 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.481720472399553 0.573630319853191 0.488291947444537 0.555555555555556 12.4 12 4 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.517057438845789 0.614680647850925 0.488291947444537 0.555555555555556 12.4 12 4 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.578860997060054 0.650133542870132 0.488291947444537 0.555555555555556 12.4 12 4 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.578860997060054 0.650133542870132 0.488291947444537 0.555555555555556 12.4 12 4 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.578860997060054 0.650133542870132 0.488291947444537 0.555555555555556 12.4 12 4 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.578860997060054 0.650133542870132 0.488291947444537 0.555555555555556 12.4 12 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.435962206476877 0.523081129693589 0.479413912036454 0.545454545454545 12.4 12 4 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.58663005371902 0.657302808222177 0.479413912036454 0.545454545454545 12.4 12 4 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.58663005371902 0.657302808222177 0.479413912036454 0.545454545454545 12.4 12 4 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.518678147078531 0.616092657172579 0.477130988645804 0.542857142857143 12.4 12 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.554308066848882 0.630519887390855 0.473267579830859 0.538461538461538 12.4 12 4 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.600281996373663 0.671541887452612 0.468760269546755 0.533333333333333 12.4 12 4 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.600281996373663 0.671541887452612 0.468760269546755 0.533333333333333 12.4 12 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.566923134303542 0.639248510391395 0.466368635518456 0.530612244897959 12.4 12 4 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.582323913689337 0.653507041940005 0.465313502858911 0.529411764705882 12.4 12 4 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.606406297584618 0.677860299656647 0.465313502858911 0.529411764705882 12.4 12 4 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.641405751523685 0.71642102387614 0.453638970529118 0.516129032258065 12.4 12 4 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.649713548924308 0.725131278524933 0.452018831348657 0.514285714285714 12.4 12 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.967902773915856 0.997339353571516 0.450610100573451 0.512682926829268 12.4 12 4 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.696697913322816 0.772721068322968 0.439462752700083 0.5 12.4 12 4 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.699391549453541 0.773899047334673 0.439462752700083 0.5 12.4 12 4 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.699391549453541 0.773899047334673 0.439462752700083 0.5 12.4 12 4 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.699391549453541 0.773899047334673 0.439462752700083 0.5 12.4 12 4 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.695472404147766 0.77256614449826 0.439462752700083 0.5 12.4 12 4 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.695472404147766 0.77256614449826 0.439462752700083 0.5 12.4 12 4 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.695472404147766 0.77256614449826 0.439462752700083 0.5 12.4 12 4 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.695472404147766 0.77256614449826 0.439462752700083 0.5 12.4 12 4 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.695278705184765 0.77256614449826 0.439462752700083 0.5 12.4 12 4 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.695472404147766 0.77256614449826 0.439462752700083 0.5 12.4 12 4 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.696660597453916 0.772721068322968 0.439462752700083 0.5 12.4 12 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.723668092273466 0.794583098229276 0.439462752700083 0.5 12.4 12 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.897038296788826 0.935107834185565 0.43632373303794 0.496428571428571 12.4 12 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.984097304274171 1 0.421340577331007 0.479381443298969 12.4 12 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.846326476601907 0.89674056307112 0.420893903994446 0.47887323943662 12.4 12 4 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.784893057026591 0.839776556502886 0.405657925569307 0.461538461538462 12.4 12 4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.793359462565642 0.848197231578444 0.399511593363712 0.454545454545455 12.4 12 4 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.827436942746353 0.877379112912117 0.399511593363712 0.454545454545455 12.4 12 4 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.827436942746353 0.877379112912117 0.399511593363712 0.454545454545455 12.4 12 4 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.859861963548182 0.905017436485993 0.396934099212978 0.451612903225806 12.4 12 4 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.859861963548182 0.905017436485993 0.396934099212978 0.451612903225806 12.4 12 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.992407390489034 1 0.392208693269967 0.446236559139785 12.4 12 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.937141974934138 0.972686382444404 0.389032600750893 0.442622950819672 12.4 12 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.997898550367076 1 0.38478305535952 0.43778801843318 12.4 12 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.995317797228285 1 0.384529908612573 0.4375 12.4 12 4 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.85195854668571 0.898027416247234 0.376682359457214 0.428571428571429 12.4 12 4 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.85195854668571 0.898027416247234 0.376682359457214 0.428571428571429 12.4 12 4 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.85195854668571 0.898027416247234 0.376682359457214 0.428571428571429 12.4 12 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.946590493085924 0.979635106662742 0.374010853361773 0.425531914893617 12.4 12 4 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_220332.1 ANDROGEN BIOSYNTHESIS 0.90075490384278 0.937654885273062 0.351570202160066 0.4 12.4 12 4 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.941255158897548 0.975532477138537 0.343927371678326 0.391304347826087 12.4 12 4 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.946397129306225 0.979635106662742 0.334828763961968 0.380952380952381 12.4 12 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.997716968444302 1 0.333769179265886 0.379746835443038 12.4 12 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999946088124764 1 0.309251566714873 0.351851851851852 12.4 12 4 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.968905006003571 0.997649655241014 0.307623926890058 0.35 12.4 12 4 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.976697870155089 1 0.305713219269623 0.347826086956522 12.4 12 4 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.99826900095227 1 0.292975168466722 0.333333333333333 12.4 12 4 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.973710554211064 1 0.292975168466722 0.333333333333333 12.4 12 4 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.965068772915726 0.995139756419621 0.292975168466722 0.333333333333333 12.4 12 4 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.965068772915726 0.995139756419621 0.292975168466722 0.333333333333333 12.4 12 4 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.997871124825663 1 0.277555422757947 0.315789473684211 12.4 12 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.27378787783666 0.311502938706969 12.4 12 4 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999993117206003 1 0.273443490568941 0.311111111111111 12.4 12 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.239995933662613 0.273056057866184 12.4 12 4 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.999290841194459 1 0.21094212129604 0.24 12.4 12 4 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.999977495740237 1 0.170114613948419 0.193548387096774 12.4 12 4 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.999996488749598 1 0.141762178290349 0.161290322580645 12.4 12 4 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.999999975107956 1 0.125560786485738 0.142857142857143 12.4 12 4 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999999999014599 1 0.112203256008532 0.127659574468085 12.4 12 4 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0340229227896839 0.0387096774193548 12.4 12 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 6.29855453644038e-09 3.58513724214186e-08 2.85062429057889 1 13.1 13 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 3.60702570329812e-07 1.67192103446033e-06 2.85062429057889 1 13.1 13 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 3.60702570329812e-07 1.67192103446033e-06 2.85062429057889 1 13.1 13 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 5.35679937317498e-06 2.0898509342291e-05 2.85062429057889 1 13.1 13 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 5.35679937317498e-06 2.0898509342291e-05 2.85062429057889 1 13.1 13 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 5.35679937317498e-06 2.0898509342291e-05 2.85062429057889 1 13.1 13 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 2.0640900652193e-05 7.39848907508077e-05 2.85062429057889 1 13.1 13 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 7.95271415904157e-05 0.000263792826301076 2.85062429057889 1 13.1 13 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.000306383642487928 0.000943688145585111 2.85062429057889 1 13.1 13 1 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.000306383642487928 0.000943688145585111 2.85062429057889 1 13.1 13 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.000306383642487928 0.000943688145585111 2.85062429057889 1 13.1 13 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.000306383642487928 0.000943688145585111 2.85062429057889 1 13.1 13 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.000306383642487928 0.000943688145585111 2.85062429057889 1 13.1 13 1 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.000306383642487928 0.000943688145585111 2.85062429057889 1 13.1 13 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.000306383642487928 0.000943688145585111 2.85062429057889 1 13.1 13 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 1.63379786796018e-09 1.00644777753564e-08 2.85062429057889 1 13.1 13 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 1.63379786796018e-09 1.00644777753564e-08 2.85062429057889 1 13.1 13 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 1.39009851933696e-06 5.92248560783382e-06 2.85062429057889 1 13.1 13 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 1.39009851933696e-06 5.92248560783382e-06 2.85062429057889 1 13.1 13 1 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.0011802642554853 0.00330613392825901 2.85062429057889 1 13.1 13 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 2.88415921270529e-23 8.73225225463751e-22 2.78275228366034 0.976190476190476 13.1 13 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 3.08789328070021e-19 6.4710631796352e-18 2.76917788227663 0.971428571428571 13.1 13 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 3.16327582311394e-15 4.54680959221327e-14 2.74881628020107 0.964285714285714 13.1 13 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 6.02200510499838e-13 6.07752713788134e-12 2.73184827847143 0.958333333333333 13.1 13 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 1.97843772079371e-08 1.06640790783691e-07 2.67246027241771 0.9375 13.1 13 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 1.97843772079371e-08 1.06640790783691e-07 2.67246027241771 0.9375 13.1 13 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 7.16051478951633e-08 3.56273165925935e-07 2.66058267120696 0.933333333333333 13.1 13 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 2.58037395140543e-07 1.21183898773925e-06 2.64700826982325 0.928571428571429 13.1 13 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 9.252744908537e-07 4.00202310177755e-06 2.6313454989959 0.923076923076923 13.1 13 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 3.2989719025591e-06 1.33744644368707e-05 2.61307226636398 0.916666666666667 13.1 13 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 1.16840580094084e-05 4.31854923308784e-05 2.59147662779899 0.909090909090909 13.1 13 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 1.16840580094084e-05 4.31854923308784e-05 2.59147662779899 0.909090909090909 13.1 13 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 2.58207970333918e-13 2.82638416757819e-12 2.565561861521 0.9 13.1 13 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 4.10571070577172e-05 0.000142498203275931 2.565561861521 0.9 13.1 13 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 4.10571070577172e-05 0.000142498203275931 2.565561861521 0.9 13.1 13 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 4.56116052418611e-41 4.32702095061122e-39 2.56268244304567 0.898989898989899 13.1 13 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.000142913710884337 0.000461147869814992 2.53388825829234 0.888888888888889 13.1 13 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.000142913710884337 0.000461147869814992 2.53388825829234 0.888888888888889 13.1 13 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.000142913710884337 0.000461147869814992 2.53388825829234 0.888888888888889 13.1 13 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.178988420576e-42 1.39808376873304e-40 2.53092810845789 0.88785046728972 13.1 13 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 4.28808356809178e-10 2.79905638412597e-09 2.49429625425653 0.875 13.1 13 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 4.34350542705746e-07 1.99380910409766e-06 2.49429625425653 0.875 13.1 13 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 4.34350542705746e-07 1.99380910409766e-06 2.49429625425653 0.875 13.1 13 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.000491730828157974 0.00148879354993361 2.49429625425653 0.875 13.1 13 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.000491730828157974 0.00148879354993361 2.49429625425653 0.875 13.1 13 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 1.50173436284679e-12 1.40819740395088e-11 2.48280180147193 0.870967741935484 13.1 13 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 4.87624690978519e-09 2.79794328734852e-08 2.46190279640904 0.863636363636364 13.1 13 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 4.87624690978519e-09 2.79794328734852e-08 2.46190279640904 0.863636363636364 13.1 13 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.001667522647873 0.00450262756721685 2.44339224906762 0.857142857142857 13.1 13 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.001667522647873 0.00450262756721685 2.44339224906762 0.857142857142857 13.1 13 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.001667522647873 0.00450262756721685 2.44339224906762 0.857142857142857 13.1 13 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.001667522647873 0.00450262756721685 2.44339224906762 0.857142857142857 13.1 13 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.33729544072811e-42 1.463824163197e-40 2.44339224906762 0.857142857142857 13.1 13 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 1.62848702770889e-08 8.84479786423571e-08 2.44339224906762 0.857142857142857 13.1 13 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 4.4649958137179e-25 1.67202343234752e-23 2.43749033542253 0.855072463768116 13.1 13 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 6.66464471958464e-13 6.67872495490771e-12 2.43141483608199 0.852941176470588 13.1 13 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 5.39888774927346e-08 2.74379188114862e-07 2.42303064699205 0.85 13.1 13 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 5.39888774927346e-08 2.74379188114862e-07 2.42303064699205 0.85 13.1 13 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 3.12559989290951e-58 6.35389806801463e-56 2.41464645790212 0.847058823529412 13.1 13 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 8.44791683742222e-56 1.33570951773909e-53 2.41341197607292 0.846625766871166 13.1 13 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.03161443629678e-57 1.83498417856289e-55 2.4120667074129 0.846153846153846 13.1 13 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 1.63543076669388e-05 5.9979844871273e-05 2.4120667074129 0.846153846153846 13.1 13 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 6.35397067938778e-38 5.02316682042712e-36 2.41007326385306 0.845454545454545 13.1 13 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.98231445718279e-29 1.4146111575237e-27 2.40945624560835 0.845238095238095 13.1 13 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.98231445718279e-29 1.4146111575237e-27 2.40945624560835 0.845238095238095 13.1 13 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 2.01819193450599e-09 1.22730218923163e-08 2.39452440408627 0.84 13.1 13 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 2.01819193450599e-09 1.22730218923163e-08 2.39452440408627 0.84 13.1 13 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 3.34487744167313e-15 4.75976059950086e-14 2.38656917350791 0.837209302325581 13.1 13 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.7092657661489e-42 5.80306084659277e-40 2.37926121890836 0.834645669291339 13.1 13 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.30782508149242e-16 2.13912079421116e-15 2.37552024214907 0.833333333333333 13.1 13 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 6.55851293973537e-09 3.70347774335057e-08 2.37552024214907 0.833333333333333 13.1 13 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 6.55851293973537e-09 3.70347774335057e-08 2.37552024214907 0.833333333333333 13.1 13 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 5.78658470078339e-07 2.5414537127206e-06 2.37552024214907 0.833333333333333 13.1 13 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 5.78658470078339e-07 2.5414537127206e-06 2.37552024214907 0.833333333333333 13.1 13 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 5.3609488543655e-05 0.000183822414934027 2.37552024214907 0.833333333333333 13.1 13 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 5.3609488543655e-05 0.000183822414934027 2.37552024214907 0.833333333333333 13.1 13 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00554966732047213 0.0132281015025659 2.37552024214907 0.833333333333333 13.1 13 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00554966732047213 0.0132281015025659 2.37552024214907 0.833333333333333 13.1 13 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00554966732047213 0.0132281015025659 2.37552024214907 0.833333333333333 13.1 13 1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.00554966732047213 0.0132281015025659 2.37552024214907 0.833333333333333 13.1 13 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00554966732047213 0.0132281015025659 2.37552024214907 0.833333333333333 13.1 13 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 3.22991060245525e-35 1.99833164664949e-33 2.37108001739739 0.831775700934579 13.1 13 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 9.7855729333546e-43 1.26589729856033e-40 2.35765918769682 0.827067669172932 13.1 13 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 9.34694776037103e-12 7.03741093280845e-11 2.34757294518261 0.823529411764706 13.1 13 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 9.34694776037103e-12 7.03741093280845e-11 2.34757294518261 0.823529411764706 13.1 13 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 1.86713137782561e-06 7.70124043665462e-06 2.34757294518261 0.823529411764706 13.1 13 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 1.86713137782561e-06 7.70124043665462e-06 2.34757294518261 0.823529411764706 13.1 13 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 1.86713137782561e-06 7.70124043665462e-06 2.34757294518261 0.823529411764706 13.1 13 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 1.86713137782561e-06 7.70124043665462e-06 2.34757294518261 0.823529411764706 13.1 13 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.86713137782561e-06 7.70124043665462e-06 2.34757294518261 0.823529411764706 13.1 13 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 3.12871941797069e-91 1.11304193294307e-88 2.3447114471997 0.822525597269625 13.1 13 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.12946639256581e-31 6.18165644854287e-30 2.33751191827469 0.82 13.1 13 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 6.76236754299559e-08 3.37643825041499e-07 2.33232896501909 0.818181818181818 13.1 13 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 6.76236754299559e-08 3.37643825041499e-07 2.33232896501909 0.818181818181818 13.1 13 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000173235827775106 0.000547810184275503 2.33232896501909 0.818181818181818 13.1 13 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.000173235827775106 0.000547810184275503 2.33232896501909 0.818181818181818 13.1 13 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000173235827775106 0.000547810184275503 2.33232896501909 0.818181818181818 13.1 13 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.000173235827775106 0.000547810184275503 2.33232896501909 0.818181818181818 13.1 13 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.000173235827775106 0.000547810184275503 2.33232896501909 0.818181818181818 13.1 13 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.2273951833774e-22 3.42467322734517e-21 2.32867899793768 0.816901408450704 13.1 13 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 5.95699832686451e-06 2.29723810816482e-05 2.31613223609535 0.8125 13.1 13 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 5.95699832686451e-06 2.29723810816482e-05 2.31613223609535 0.8125 13.1 13 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 5.95699832686451e-06 2.29723810816482e-05 2.31613223609535 0.8125 13.1 13 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 5.95699832686451e-06 2.29723810816482e-05 2.31613223609535 0.8125 13.1 13 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.87516741030581e-24 6.50820298747601e-23 2.30936651388669 0.810126582278481 13.1 13 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 9.86520030133351e-20 2.12699697406024e-18 2.30764823523053 0.80952380952381 13.1 13 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 2.14230908159228e-07 1.02643293707267e-06 2.30764823523053 0.80952380952381 13.1 13 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 5.29023826060003e-15 7.38040102434691e-14 2.30476006472336 0.808510638297872 13.1 13 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.09228598886292e-19 6.4710631796352e-18 2.29889055691846 0.806451612903226 13.1 13 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2.9650863098981e-10 1.9716438406472e-09 2.29889055691846 0.806451612903226 13.1 13 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.90456924286618e-124 1.37773401086619e-121 2.29522096635812 0.805164319248826 13.1 13 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.33741756187009e-76 9.49829038108227e-74 2.29360575104048 0.804597701149425 13.1 13 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 5.74643201673298e-23 1.63543455196221e-21 2.28800107533305 0.802631578947368 13.1 13 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 2.47197969606531e-08 1.30766806970295e-07 2.28049943246311 0.8 13.1 13 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 1.87640973167211e-05 6.75982543840359e-05 2.28049943246311 0.8 13.1 13 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 1.87640973167211e-05 6.75982543840359e-05 2.28049943246311 0.8 13.1 13 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.000550340126190817 0.00164179035549168 2.28049943246311 0.8 13.1 13 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.000550340126190817 0.00164179035549168 2.28049943246311 0.8 13.1 13 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.000550340126190817 0.00164179035549168 2.28049943246311 0.8 13.1 13 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.000550340126190817 0.00164179035549168 2.28049943246311 0.8 13.1 13 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 5.53814550678637e-22 1.45940389928833e-20 2.27279504248857 0.797297297297297 13.1 13 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 5.53814550678637e-22 1.45940389928833e-20 2.27279504248857 0.797297297297297 13.1 13 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.41623500459082e-20 3.35883735255455e-19 2.27223675335998 0.797101449275362 13.1 13 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.41623500459082e-20 3.35883735255455e-19 2.27223675335998 0.797101449275362 13.1 13 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.10077722851901e-148 1.56640599618256e-145 2.27074444439649 0.796577946768061 13.1 13 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.11913858301306e-18 2.27504886232512e-17 2.26240023061816 0.793650793650794 13.1 13 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.86940975018172e-17 4.80372949942186e-16 2.26083995459705 0.793103448275862 13.1 13 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 8.09096689055878e-24 2.61669224665117e-22 2.25964120594668 0.792682926829268 13.1 13 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 7.65923575887071e-08 3.78440711280313e-07 2.25674423004162 0.791666666666667 13.1 13 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 2.08282689556211e-06 8.54139098669993e-06 2.25049286098333 0.789473684210526 13.1 13 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 2.08282689556211e-06 8.54139098669993e-06 2.25049286098333 0.789473684210526 13.1 13 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.05270133045782e-17 1.87249249155185e-16 2.24311419586535 0.786885245901639 13.1 13 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.05270133045782e-17 1.87249249155185e-16 2.24311419586535 0.786885245901639 13.1 13 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.05270133045782e-17 1.87249249155185e-16 2.24311419586535 0.786885245901639 13.1 13 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.6935882914428e-16 4.35565470309443e-15 2.23977622831198 0.785714285714286 13.1 13 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 8.80508730258571e-09 4.85644931456568e-08 2.23977622831198 0.785714285714286 13.1 13 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 5.82482132068948e-05 0.000195488696682574 2.23977622831198 0.785714285714286 13.1 13 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 5.82482132068948e-05 0.000195488696682574 2.23977622831198 0.785714285714286 13.1 13 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 5.82482132068948e-05 0.000195488696682574 2.23977622831198 0.785714285714286 13.1 13 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 5.82482132068948e-05 0.000195488696682574 2.23977622831198 0.785714285714286 13.1 13 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 5.82482132068948e-05 0.000195488696682574 2.23977622831198 0.785714285714286 13.1 13 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 5.82482132068948e-05 0.000195488696682574 2.23977622831198 0.785714285714286 13.1 13 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.50418837245631e-12 1.40819740395088e-11 2.23977622831198 0.785714285714286 13.1 13 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 2.34932876908021e-07 1.1108500779047e-06 2.23092335784435 0.782608695652174 13.1 13 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 8.19486754263959e-16 1.25390285087915e-14 2.22866989990713 0.781818181818182 13.1 13 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 8.19486754263959e-16 1.25390285087915e-14 2.22866989990713 0.781818181818182 13.1 13 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 8.19486754263959e-16 1.25390285087915e-14 2.22866989990713 0.781818181818182 13.1 13 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 8.19486754263959e-16 1.25390285087915e-14 2.22866989990713 0.781818181818182 13.1 13 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 3.33261290076636e-24 1.10286236227687e-22 2.22807415815361 0.781609195402299 13.1 13 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 3.33261290076636e-24 1.10286236227687e-22 2.22807415815361 0.781609195402299 13.1 13 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.82085965746591e-18 7.24944439009865e-17 2.22705022701476 0.78125 13.1 13 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.79275289751875e-20 4.11465705349868e-19 2.2258299255205 0.780821917808219 13.1 13 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 5.42314584469198e-20 1.18725177492257e-18 2.2171522260058 0.777777777777778 13.1 13 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 5.42314584469198e-20 1.18725177492257e-18 2.2171522260058 0.777777777777778 13.1 13 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 5.42314584469198e-20 1.18725177492257e-18 2.2171522260058 0.777777777777778 13.1 13 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.48087559783309e-15 3.67738122470467e-14 2.2171522260058 0.777777777777778 13.1 13 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.48087559783309e-15 3.67738122470467e-14 2.2171522260058 0.777777777777778 13.1 13 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 2.67992364717617e-08 1.40203358453371e-07 2.2171522260058 0.777777777777778 13.1 13 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 6.37678655494109e-06 2.42624793253507e-05 2.2171522260058 0.777777777777778 13.1 13 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00171259073861571 0.00455517125429934 2.2171522260058 0.777777777777778 13.1 13 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00171259073861571 0.00455517125429934 2.2171522260058 0.777777777777778 13.1 13 1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.00171259073861571 0.00455517125429934 2.2171522260058 0.777777777777778 13.1 13 1 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.00171259073861571 0.00455517125429934 2.2171522260058 0.777777777777778 13.1 13 1 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.00171259073861571 0.00455517125429934 2.2171522260058 0.777777777777778 13.1 13 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00171259073861571 0.00455517125429934 2.2171522260058 0.777777777777778 13.1 13 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00171259073861571 0.00455517125429934 2.2171522260058 0.777777777777778 13.1 13 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.37421734657595e-18 2.71598789469108e-17 2.21242482253884 0.776119402985075 13.1 13 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.38281873848256e-11 1.0143046726086e-10 2.20923382519864 0.775 13.1 13 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 7.47192590031029e-15 9.94837801639553e-14 2.20519992290065 0.773584905660377 13.1 13 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 8.07700836555931e-08 3.963304449721e-07 2.19278791582991 0.769230769230769 13.1 13 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 8.07700836555931e-08 3.963304449721e-07 2.19278791582991 0.769230769230769 13.1 13 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000177793424799376 0.000559734609490071 2.19278791582991 0.769230769230769 13.1 13 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.52545026470757e-26 2.1250583045078e-24 2.18835804125248 0.767676767676768 13.1 13 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.11639869503026e-16 4.98273634048096e-15 2.18547862277715 0.766666666666667 13.1 13 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 5.67736668453586e-13 5.85427013919893e-12 2.18345690342213 0.765957446808511 13.1 13 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.06613011090525e-09 6.80881676507848e-09 2.17988916338386 0.764705882352941 13.1 13 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 7.8484395539795e-15 1.02461738397365e-13 2.17684036735115 0.763636363636364 13.1 13 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 7.8484395539795e-15 1.02461738397365e-13 2.17684036735115 0.763636363636364 13.1 13 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 9.25410291478335e-16 1.40091366465284e-14 2.17420496739068 0.76271186440678 13.1 13 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 1.44046132445515e-11 1.04580431872433e-10 2.17190422139344 0.761904761904762 13.1 13 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 2.1359326409486e-06 8.70897463630331e-06 2.17190422139344 0.761904761904762 13.1 13 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 8.20425642886239e-28 3.76601835428103e-26 2.17065886346833 0.761467889908257 13.1 13 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.73390012374384e-15 4.01065966606957e-14 2.16254256526674 0.758620689655172 13.1 13 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 4.505833746098e-18 8.43658081670718e-17 2.15832982000973 0.757142857142857 13.1 13 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.25108421556718e-11 3.00959842723985e-10 2.15535007336452 0.75609756097561 13.1 13 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.25108421556718e-11 3.00959842723985e-10 2.15535007336452 0.75609756097561 13.1 13 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.50882155133298e-24 5.36763266886709e-23 2.13796821793417 0.75 13.1 13 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.07180249850849e-09 6.80881676507848e-09 2.13796821793417 0.75 13.1 13 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.07180249850849e-09 6.80881676507848e-09 2.13796821793417 0.75 13.1 13 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 6.3159707629212e-06 2.40955131250318e-05 2.13796821793417 0.75 13.1 13 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 6.3159707629212e-06 2.40955131250318e-05 2.13796821793417 0.75 13.1 13 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 6.3159707629212e-06 2.40955131250318e-05 2.13796821793417 0.75 13.1 13 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 5.71853942862909e-05 0.000194676593467445 2.13796821793417 0.75 13.1 13 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 5.71853942862909e-05 0.000194676593467445 2.13796821793417 0.75 13.1 13 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 5.71853942862909e-05 0.000194676593467445 2.13796821793417 0.75 13.1 13 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00053211484546946 0.00160423607013356 2.13796821793417 0.75 13.1 13 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00053211484546946 0.00160423607013356 2.13796821793417 0.75 13.1 13 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00519489810701809 0.0126149146864961 2.13796821793417 0.75 13.1 13 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00519489810701809 0.0126149146864961 2.13796821793417 0.75 13.1 13 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00519489810701809 0.0126149146864961 2.13796821793417 0.75 13.1 13 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00519489810701809 0.0126149146864961 2.13796821793417 0.75 13.1 13 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00519489810701809 0.0126149146864961 2.13796821793417 0.75 13.1 13 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00519489810701809 0.0126149146864961 2.13796821793417 0.75 13.1 13 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00519489810701809 0.0126149146864961 2.13796821793417 0.75 13.1 13 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00519489810701809 0.0126149146864961 2.13796821793417 0.75 13.1 13 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.69517479325498e-23 1.07310892465344e-21 2.13046657506422 0.747368421052632 13.1 13 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.69517479325498e-23 1.07310892465344e-21 2.13046657506422 0.747368421052632 13.1 13 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 5.7984119103679e-13 5.93607204924714e-12 2.12399456945094 0.745098039215686 13.1 13 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.27238167928776e-23 3.93608506440538e-22 2.12342421645162 0.744897959183674 13.1 13 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 9.01580925857619e-22 2.33263574090071e-20 2.12213141631984 0.744444444444444 13.1 13 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 3.11533885654982e-09 1.83947186426157e-08 2.1176066158586 0.742857142857143 13.1 13 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 3.11533885654982e-09 1.83947186426157e-08 2.1176066158586 0.742857142857143 13.1 13 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.34972504180826e-07 1.1108500779047e-06 2.11157354857695 0.740740740740741 13.1 13 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.67382109846598e-12 1.52682527122891e-11 2.10946197502838 0.74 13.1 13 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.42542949355851e-11 1.04019803555578e-10 2.10698317129744 0.739130434782609 13.1 13 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 8.97138729814414e-09 4.92906722982977e-08 2.09604727248448 0.735294117647059 13.1 13 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.273208369718e-17 2.23675988902311e-16 2.09045781309118 0.733333333333333 13.1 13 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.25370293360984e-14 2.86341006654179e-13 2.09045781309118 0.733333333333333 13.1 13 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 3.48185143046749e-10 2.29383082664595e-09 2.08582265164309 0.731707317073171 13.1 13 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.61199864497544e-12 1.47991875600004e-11 2.08314852003842 0.730769230769231 13.1 13 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.61199864497544e-12 1.47991875600004e-11 2.08314852003842 0.730769230769231 13.1 13 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 6.75372933270462e-07 2.93900820808522e-06 2.08314852003842 0.730769230769231 13.1 13 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.81780375009128e-25 1.75788070163587e-23 2.08018529312513 0.72972972972973 13.1 13 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.36636352376835e-11 1.00742761363853e-10 2.07858021188044 0.729166666666667 13.1 13 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00155595158863271 0.00423349734344999 2.07318130223919 0.727272727272727 13.1 13 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00155595158863271 0.00423349734344999 2.07318130223919 0.727272727272727 13.1 13 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.36315376849309e-21 6.0049425224387e-20 2.07045343210467 0.726315789473684 13.1 13 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 2.20729777662917e-07 1.05049656727201e-06 2.06424517593644 0.724137931034483 13.1 13 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.08252965395199e-23 3.4231993279415e-22 2.05878420986253 0.722222222222222 13.1 13 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.52310923195533e-12 1.41659113534146e-11 2.05878420986253 0.722222222222222 13.1 13 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 7.21698949685903e-08 3.57831918258899e-07 2.04888620885358 0.71875 13.1 13 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.65739256840022e-26 6.55130451342645e-25 2.04601259565743 0.717741935483871 13.1 13 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.65739256840022e-26 6.55130451342645e-25 2.04601259565743 0.717741935483871 13.1 13 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.65739256840022e-26 6.55130451342645e-25 2.04601259565743 0.717741935483871 13.1 13 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 6.73462725606434e-15 9.12702341464719e-14 2.04223829772816 0.716417910447761 13.1 13 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 6.73462725606434e-15 9.12702341464719e-14 2.04223829772816 0.716417910447761 13.1 13 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 6.73462725606434e-15 9.12702341464719e-14 2.04223829772816 0.716417910447761 13.1 13 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.34044544751722e-19 8.9513824229232e-18 2.0407878443917 0.715909090909091 13.1 13 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 6.20449554684661e-07 2.70828133839348e-06 2.03616020755635 0.714285714285714 13.1 13 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.01525502900197 0.0335516325653837 2.03616020755635 0.714285714285714 13.1 13 1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.01525502900197 0.0335516325653837 2.03616020755635 0.714285714285714 13.1 13 1 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.01525502900197 0.0335516325653837 2.03616020755635 0.714285714285714 13.1 13 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 1.67660660678527e-05 6.10181892955355e-05 2.03616020755635 0.714285714285714 13.1 13 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.67660660678527e-05 6.10181892955355e-05 2.03616020755635 0.714285714285714 13.1 13 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.20489047570549e-18 2.41487203792805e-17 2.031479379493 0.71264367816092 13.1 13 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.69525633913643e-13 4.87689764276725e-12 2.02925796956463 0.711864406779661 13.1 13 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.69525633913643e-13 4.87689764276725e-12 2.02925796956463 0.711864406779661 13.1 13 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.32947227155257e-18 6.40248519245852e-17 2.02195443866642 0.709302325581395 13.1 13 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 5.36047498941408e-06 2.0898509342291e-05 2.01919220582671 0.708333333333333 13.1 13 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.3195756820678e-26 5.69017028964389e-25 2.01736488256352 0.707692307692308 13.1 13 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.53282868457637e-09 1.50803984023103e-08 2.01629522992165 0.707317073170732 13.1 13 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.53282868457637e-09 1.50803984023103e-08 2.01629522992165 0.707317073170732 13.1 13 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.53282868457637e-09 1.50803984023103e-08 2.01629522992165 0.707317073170732 13.1 13 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.53282868457637e-09 1.50803984023103e-08 2.01629522992165 0.707317073170732 13.1 13 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000148232582386411 0.000474011156709804 2.0122053815851 0.705882352941177 13.1 13 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000148232582386411 0.000474011156709804 2.0122053815851 0.705882352941177 13.1 13 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000148232582386411 0.000474011156709804 2.0122053815851 0.705882352941177 13.1 13 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.72132395235835e-06 7.20424701237038e-06 2.00599487114811 0.703703703703704 13.1 13 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 1.72132395235835e-06 7.20424701237038e-06 2.00599487114811 0.703703703703704 13.1 13 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.13099171922379e-08 1.14000045731408e-07 2.00314139337976 0.702702702702703 13.1 13 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.13099171922379e-08 1.14000045731408e-07 2.00314139337976 0.702702702702703 13.1 13 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 6.94964785239983e-09 3.878176036849e-08 1.99543700340522 0.7 13.1 13 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00442450883427379 0.0110071259985518 1.99543700340522 0.7 13.1 13 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00442450883427379 0.0110071259985518 1.99543700340522 0.7 13.1 13 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00442450883427379 0.0110071259985518 1.99543700340522 0.7 13.1 13 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.00442450883427379 0.0110071259985518 1.99543700340522 0.7 13.1 13 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00442450883427379 0.0110071259985518 1.99543700340522 0.7 13.1 13 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 5.54743540297895e-07 2.45155297467051e-06 1.99543700340522 0.7 13.1 13 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.26950149179317e-09 1.37425558417944e-08 1.98880764458992 0.697674418604651 13.1 13 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.20136419186579e-14 4.74487400398812e-13 1.98304298475053 0.695652173913043 13.1 13 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 7.42029278382781e-10 4.79958028699408e-09 1.98304298475053 0.695652173913043 13.1 13 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 5.81182697991135e-08 2.93270560014675e-07 1.97960020179089 0.694444444444444 13.1 13 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.42872314017532e-10 1.63794930259217e-09 1.97798420162617 0.693877551020408 13.1 13 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 4.70808990836614e-06 1.87139998312989e-05 1.97350912424692 0.692307692307692 13.1 13 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 4.70808990836614e-06 1.87139998312989e-05 1.97350912424692 0.692307692307692 13.1 13 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00132933804197715 0.0036946250658857 1.97350912424692 0.692307692307692 13.1 13 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00132933804197715 0.0036946250658857 1.97350912424692 0.692307692307692 13.1 13 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 1.5087157258441e-06 6.37063049814883e-06 1.96594778660613 0.689655172413793 13.1 13 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 1.5087157258441e-06 6.37063049814883e-06 1.96594778660613 0.689655172413793 13.1 13 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.5087157258441e-06 6.37063049814883e-06 1.96594778660613 0.689655172413793 13.1 13 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.00251999036009e-09 1.22730218923163e-08 1.96376340017657 0.688888888888889 13.1 13 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 9.23843926939973e-13 9.04074838374491e-12 1.95980419977299 0.6875 13.1 13 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000408046634665752 0.00124603081787417 1.95980419977299 0.6875 13.1 13 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 3.03727245840473e-13 3.27427174871964e-12 1.95714503532282 0.686567164179104 13.1 13 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 9.99043234971063e-14 1.11065509637799e-12 1.95471379925409 0.685714285714286 13.1 13 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.08229342663111e-14 1.38748067215862e-13 1.95042714618555 0.684210526315789 13.1 13 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.54559582124008e-21 6.35505763793795e-20 1.95042714618555 0.684210526315789 13.1 13 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 8.08683858344923e-13 8.04725266031347e-12 1.94360747084924 0.681818181818182 13.1 13 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 3.99835683168768e-05 0.000139795129520678 1.94360747084924 0.681818181818182 13.1 13 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 3.99835683168768e-05 0.000139795129520678 1.94360747084924 0.681818181818182 13.1 13 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 7.22497041412347e-40 6.047725234881e-38 1.94302642227799 0.681614349775785 13.1 13 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.65668671570414e-13 2.8858512949977e-12 1.94172958923489 0.681159420289855 13.1 13 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.629444997163e-37 1.10414296712521e-35 1.94113939787039 0.680952380952381 13.1 13 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.629444997163e-37 1.10414296712521e-35 1.94113939787039 0.680952380952381 13.1 13 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.26795403750028e-05 4.66227027225556e-05 1.93842451759364 0.68 13.1 13 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.78752771818107e-20 4.11465705349868e-19 1.93435219717853 0.678571428571429 13.1 13 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 4.04539212522502e-06 1.61702050398742e-05 1.93435219717853 0.678571428571429 13.1 13 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 4.36504949355834e-08 2.24240629217817e-07 1.92417139614075 0.675 13.1 13 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.50104342506755e-09 9.49326575053833e-09 1.91980819569599 0.673469387755102 13.1 13 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.29846138921239e-31 6.59896627446156e-30 1.91599337563499 0.672131147540984 13.1 13 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000339263762683993 0.0010404576170244 1.90041619371926 0.666666666666667 13.1 13 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00360362507495921 0.00917344987775843 1.90041619371926 0.666666666666667 13.1 13 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00360362507495921 0.00917344987775843 1.90041619371926 0.666666666666667 13.1 13 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00360362507495921 0.00917344987775843 1.90041619371926 0.666666666666667 13.1 13 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00360362507495921 0.00917344987775843 1.90041619371926 0.666666666666667 13.1 13 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00360362507495921 0.00917344987775843 1.90041619371926 0.666666666666667 13.1 13 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00360362507495921 0.00917344987775843 1.90041619371926 0.666666666666667 13.1 13 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00360362507495921 0.00917344987775843 1.90041619371926 0.666666666666667 13.1 13 1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0121595128438228 0.0271206689290908 1.90041619371926 0.666666666666667 13.1 13 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0121595128438228 0.0271206689290908 1.90041619371926 0.666666666666667 13.1 13 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0121595128438228 0.0271206689290908 1.90041619371926 0.666666666666667 13.1 13 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0121595128438228 0.0271206689290908 1.90041619371926 0.666666666666667 13.1 13 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0121595128438228 0.0271206689290908 1.90041619371926 0.666666666666667 13.1 13 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.20543735193156e-08 6.59745135307158e-08 1.90041619371926 0.666666666666667 13.1 13 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 3.41666009693652e-06 1.38122366986951e-05 1.90041619371926 0.666666666666667 13.1 13 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.000106254808535868 0.000347587569072505 1.90041619371926 0.666666666666667 13.1 13 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000106254808535868 0.000347587569072505 1.90041619371926 0.666666666666667 13.1 13 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000106254808535868 0.000347587569072505 1.90041619371926 0.666666666666667 13.1 13 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000106254808535868 0.000347587569072505 1.90041619371926 0.666666666666667 13.1 13 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00109631029753199 0.00315161525936975 1.90041619371926 0.666666666666667 13.1 13 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00109631029753199 0.00315161525936975 1.90041619371926 0.666666666666667 13.1 13 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00109631029753199 0.00315161525936975 1.90041619371926 0.666666666666667 13.1 13 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.5305564020044e-27 6.80619300016331e-26 1.89462224190914 0.664634146341463 13.1 13 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.12087197762531e-08 1.62080322049665e-07 1.87882055515427 0.659090909090909 13.1 13 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 2.96475792058038e-07 1.38777977664009e-06 1.87541071748611 0.657894736842105 13.1 13 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.1280225729848e-12 1.07011741423825e-11 1.87438309517516 0.657534246575342 13.1 13 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.96508156638981e-10 1.9716438406472e-09 1.86765039727582 0.655172413793103 13.1 13 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.96508156638981e-10 1.9716438406472e-09 1.86765039727582 0.655172413793103 13.1 13 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 9.46641960068863e-13 9.04074838374491e-12 1.86240786984487 0.653333333333333 13.1 13 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 9.46641960068863e-13 9.04074838374491e-12 1.86240786984487 0.653333333333333 13.1 13 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 9.46641960068863e-13 9.04074838374491e-12 1.86240786984487 0.653333333333333 13.1 13 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 9.46641960068863e-13 9.04074838374491e-12 1.86240786984487 0.653333333333333 13.1 13 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 9.46641960068863e-13 9.04074838374491e-12 1.86240786984487 0.653333333333333 13.1 13 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 8.48414350139076e-09 4.71599070409338e-08 1.8616321897658 0.653061224489796 13.1 13 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.87791531029553e-12 2.23785436423526e-11 1.86082418968344 0.652777777777778 13.1 13 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 2.60171973771953e-08 1.36614287334867e-07 1.85910279820362 0.652173913043478 13.1 13 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.60171973771953e-08 1.36614287334867e-07 1.85910279820362 0.652173913043478 13.1 13 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.82873929454061e-14 3.562208863833e-13 1.85622046828393 0.651162790697674 13.1 13 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000884372397177876 0.00256828963506963 1.84452159978634 0.647058823529412 13.1 13 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000884372397177876 0.00256828963506963 1.84452159978634 0.647058823529412 13.1 13 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 2.15211813391236e-08 1.14699030133232e-07 1.84102818766553 0.645833333333333 13.1 13 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 6.59259723669528e-08 3.31493493562452e-07 1.83706898726195 0.644444444444444 13.1 13 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00286416490073097 0.00745101764851951 1.83254418680071 0.642857142857143 13.1 13 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.00286416490073097 0.00745101764851951 1.83254418680071 0.642857142857143 13.1 13 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00286416490073097 0.00745101764851951 1.83254418680071 0.642857142857143 13.1 13 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.29162894691381e-32 7.35195196583338e-31 1.82699102259829 0.640909090909091 13.1 13 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 7.07217836881806e-05 0.000235133406981965 1.82439954597049 0.64 13.1 13 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 7.07217836881806e-05 0.000235133406981965 1.82439954597049 0.64 13.1 13 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 1.56033844460083e-09 9.73842809941661e-09 1.81850170261067 0.637931034482759 13.1 13 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 1.56033844460083e-09 9.73842809941661e-09 1.81850170261067 0.637931034482759 13.1 13 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 1.56033844460083e-09 9.73842809941661e-09 1.81850170261067 0.637931034482759 13.1 13 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00944448401414566 0.0216069143924908 1.81403363945929 0.636363636363636 13.1 13 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00944448401414566 0.0216069143924908 1.81403363945929 0.636363636363636 13.1 13 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00944448401414566 0.0216069143924908 1.81403363945929 0.636363636363636 13.1 13 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00944448401414566 0.0216069143924908 1.81403363945929 0.636363636363636 13.1 13 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.00944448401414566 0.0216069143924908 1.81403363945929 0.636363636363636 13.1 13 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.3197680555544e-124 9.39014971526956e-122 1.80905003055968 0.634615384615385 13.1 13 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 5.05610553830753e-07 2.24838693156613e-06 1.80771296475734 0.634146341463415 13.1 13 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 5.05610553830753e-07 2.24838693156613e-06 1.80771296475734 0.634146341463415 13.1 13 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.34998179417078e-12 2.57676978005677e-11 1.80419258897398 0.632911392405063 13.1 13 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.34998179417078e-12 2.57676978005677e-11 1.80419258897398 0.632911392405063 13.1 13 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000703023214228223 0.00206694635092306 1.80039428878667 0.631578947368421 13.1 13 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.34005647349481e-07 6.55292220544025e-07 1.79713270493017 0.630434782608696 13.1 13 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.03627176281443e-09 6.67246478952462e-09 1.7931346343964 0.629032258064516 13.1 13 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 4.08699019918975e-07 1.88824254982046e-06 1.78992688013093 0.627906976744186 13.1 13 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 3.56133605228769e-08 1.84282952814741e-07 1.78862700585342 0.627450980392157 13.1 13 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.24758048123298e-06 5.34731031564619e-06 1.7816401816118 0.625 13.1 13 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00224341640230906 0.00590089009331939 1.7816401816118 0.625 13.1 13 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0320219138268898 0.0626783815346137 1.7816401816118 0.625 13.1 13 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0320219138268898 0.0626783815346137 1.7816401816118 0.625 13.1 13 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0320219138268898 0.0626783815346137 1.7816401816118 0.625 13.1 13 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0320219138268898 0.0626783815346137 1.7816401816118 0.625 13.1 13 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0320219138268898 0.0626783815346137 1.7816401816118 0.625 13.1 13 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0320219138268898 0.0626783815346137 1.7816401816118 0.625 13.1 13 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0320219138268898 0.0626783815346137 1.7816401816118 0.625 13.1 13 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.7989057358695e-12 1.60996406424044e-11 1.77744808706684 0.623529411764706 13.1 13 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.7989057358695e-12 1.60996406424044e-11 1.77744808706684 0.623529411764706 13.1 13 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.7989057358695e-12 1.60996406424044e-11 1.77744808706684 0.623529411764706 13.1 13 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 3.81198052289847e-06 1.53233002375269e-05 1.77200969414363 0.621621621621622 13.1 13 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.62022968167851e-11 1.17034864823783e-10 1.7681087371945 0.620253164556962 13.1 13 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.81254442924943e-10 1.22821462991521e-09 1.766584067401 0.619718309859155 13.1 13 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 1.16595089128753e-05 4.31854923308784e-05 1.76067970888696 0.617647058823529 13.1 13 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.30402100762163e-11 9.71529787353707e-11 1.75964462381413 0.617283950617284 13.1 13 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.30402100762163e-11 9.71529787353707e-11 1.75964462381413 0.617283950617284 13.1 13 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.6336512562179e-09 1.00644777753564e-08 1.75423033266393 0.615384615384615 13.1 13 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0072424843277305 0.0167675133939874 1.75423033266393 0.615384615384615 13.1 13 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0072424843277305 0.0167675133939874 1.75423033266393 0.615384615384615 13.1 13 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0072424843277305 0.0167675133939874 1.75423033266393 0.615384615384615 13.1 13 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0072424843277305 0.0167675133939874 1.75423033266393 0.615384615384615 13.1 13 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 3.57010315732055e-05 0.000126060962602162 1.74715682325803 0.612903225806452 13.1 13 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00174097167995398 0.00459629443520318 1.74204817757599 0.611111111111111 13.1 13 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00174097167995398 0.00459629443520318 1.74204817757599 0.611111111111111 13.1 13 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00174097167995398 0.00459629443520318 1.74204817757599 0.611111111111111 13.1 13 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00174097167995398 0.00459629443520318 1.74204817757599 0.611111111111111 13.1 13 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 2.61369516723658e-17 4.42772407497339e-16 1.74083926142222 0.610687022900763 13.1 13 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 2.61369516723658e-17 4.42772407497339e-16 1.74083926142222 0.610687022900763 13.1 13 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 7.48509230154572e-41 6.65705396568722e-39 1.74010501173374 0.610429447852761 13.1 13 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.66322213441302e-07 8.05022141928481e-07 1.7327324119205 0.607843137254902 13.1 13 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.66322213441302e-07 8.05022141928481e-07 1.7327324119205 0.607843137254902 13.1 13 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 2.80887982840941e-05 9.96767081253512e-05 1.72765108519933 0.606060606060606 13.1 13 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 7.28007899688316e-06 2.74789188662195e-05 1.72537786008722 0.605263157894737 13.1 13 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 7.28007899688316e-06 2.74789188662195e-05 1.72537786008722 0.605263157894737 13.1 13 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.72714737245265e-22 1.01994821365387e-20 1.72325875193187 0.604519774011299 13.1 13 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.37492215798483e-12 2.58199689828624e-11 1.71650494916578 0.602150537634409 13.1 13 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.72139232377879e-11 2.66107601846091e-10 1.71037457434733 0.6 13.1 13 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00134277126926619 0.00369586753610404 1.71037457434733 0.6 13.1 13 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00134277126926619 0.00369586753610404 1.71037457434733 0.6 13.1 13 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00134277126926619 0.00369586753610404 1.71037457434733 0.6 13.1 13 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00134277126926619 0.00369586753610404 1.71037457434733 0.6 13.1 13 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00134277126926619 0.00369586753610404 1.71037457434733 0.6 13.1 13 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0237620188581464 0.0487224104252772 1.71037457434733 0.6 13.1 13 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0237620188581464 0.0487224104252772 1.71037457434733 0.6 13.1 13 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0237620188581464 0.0487224104252772 1.71037457434733 0.6 13.1 13 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0237620188581464 0.0487224104252772 1.71037457434733 0.6 13.1 13 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0237620188581464 0.0487224104252772 1.71037457434733 0.6 13.1 13 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0237620188581464 0.0487224104252772 1.71037457434733 0.6 13.1 13 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0237620188581464 0.0487224104252772 1.71037457434733 0.6 13.1 13 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00551594680552945 0.0132281015025659 1.71037457434733 0.6 13.1 13 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00551594680552945 0.0132281015025659 1.71037457434733 0.6 13.1 13 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00551594680552945 0.0132281015025659 1.71037457434733 0.6 13.1 13 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 3.0926545747635e-07 1.44290080652081e-06 1.69941063476818 0.596153846153846 13.1 13 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.24065261388125e-10 2.14485984630373e-09 1.69594103363554 0.594936708860759 13.1 13 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000259886938533575 0.000812789260512698 1.68925883886156 0.592592592592593 13.1 13 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000259886938533575 0.000812789260512698 1.68925883886156 0.592592592592593 13.1 13 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000259886938533575 0.000812789260512698 1.68925883886156 0.592592592592593 13.1 13 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.18408384742398e-31 6.24056042549749e-30 1.68773423702144 0.592057761732852 13.1 13 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 5.15592116715495e-05 0.000177648324960327 1.67683781798758 0.588235294117647 13.1 13 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00418490783821074 0.0105028639396365 1.67683781798758 0.588235294117647 13.1 13 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00418490783821074 0.0105028639396365 1.67683781798758 0.588235294117647 13.1 13 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00418490783821074 0.0105028639396365 1.67683781798758 0.588235294117647 13.1 13 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00418490783821074 0.0105028639396365 1.67683781798758 0.588235294117647 13.1 13 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.866723791229e-18 3.63883281495734e-17 1.6747417707151 0.5875 13.1 13 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 5.87624825181135e-10 3.81821975448747e-09 1.6747417707151 0.5875 13.1 13 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 6.9108641851738e-18 1.27716360201329e-16 1.67359232543664 0.587096774193548 13.1 13 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.88195024103227e-12 1.67375949561807e-11 1.67200078582031 0.586538461538462 13.1 13 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.03940095747717e-05 3.89228305918424e-05 1.66865812131447 0.585365853658537 13.1 13 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 2.11885474565448e-06 8.6641675375469e-06 1.66286416950435 0.583333333333333 13.1 13 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 3.98928156982129e-05 0.000139795129520678 1.66286416950435 0.583333333333333 13.1 13 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000789747873176966 0.00230289185149759 1.66286416950435 0.583333333333333 13.1 13 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000789747873176966 0.00230289185149759 1.66286416950435 0.583333333333333 13.1 13 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0176216865290067 0.0374263581056366 1.66286416950435 0.583333333333333 13.1 13 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0176216865290067 0.0374263581056366 1.66286416950435 0.583333333333333 13.1 13 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0176216865290067 0.0374263581056366 1.66286416950435 0.583333333333333 13.1 13 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0176216865290067 0.0374263581056366 1.66286416950435 0.583333333333333 13.1 13 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0176216865290067 0.0374263581056366 1.66286416950435 0.583333333333333 13.1 13 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 5.16154005202138e-14 5.78336338112317e-13 1.65896987402542 0.581967213114754 13.1 13 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.6447991776451e-06 6.92470186328101e-06 1.65336208853575 0.58 13.1 13 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.23555759488198e-06 2.39816174527488e-05 1.64702736789002 0.577777777777778 13.1 13 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000603505651484992 0.00178914279596488 1.64459093687244 0.576923076923077 13.1 13 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000603505651484992 0.00178914279596488 1.64459093687244 0.576923076923077 13.1 13 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000603505651484992 0.00178914279596488 1.64459093687244 0.576923076923077 13.1 13 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000118571767242604 0.000386104404545138 1.64126853093936 0.575757575757576 13.1 13 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 2.03520643713064e-07 9.78411743255709e-07 1.63560410115182 0.573770491803279 13.1 13 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000460488313461072 0.00140315817998952 1.62892816604508 0.571428571428571 13.1 13 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0130802435637299 0.0290377325915563 1.62892816604508 0.571428571428571 13.1 13 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0130802435637299 0.0290377325915563 1.62892816604508 0.571428571428571 13.1 13 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0130802435637299 0.0290377325915563 1.62892816604508 0.571428571428571 13.1 13 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0023955159254053 0.00626621169458041 1.62892816604508 0.571428571428571 13.1 13 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.54738471252815e-07 2.04130234887304e-06 1.61535376466137 0.566666666666667 13.1 13 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.54738471252815e-07 2.04130234887304e-06 1.61535376466137 0.566666666666667 13.1 13 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.54738471252815e-07 2.04130234887304e-06 1.61535376466137 0.566666666666667 13.1 13 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.54738471252815e-07 2.04130234887304e-06 1.61535376466137 0.566666666666667 13.1 13 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.54738471252815e-07 2.04130234887304e-06 1.61535376466137 0.566666666666667 13.1 13 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.54738471252815e-07 2.04130234887304e-06 1.61535376466137 0.566666666666667 13.1 13 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.54738471252815e-07 2.04130234887304e-06 1.61535376466137 0.566666666666667 13.1 13 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.000350978795155884 0.00107407059248779 1.61535376466137 0.566666666666667 13.1 13 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.16581883202857e-09 1.8538930855871e-08 1.61420893562901 0.566265060240964 13.1 13 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 1.07995129684891e-05 4.02295993564399e-05 1.61122242510981 0.565217391304348 13.1 13 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0018101689258962 0.00477013033620424 1.61122242510981 0.565217391304348 13.1 13 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.36128344863277e-11 1.00742761363853e-10 1.60671550923537 0.563636363636364 13.1 13 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00972348589538422 0.0221030677781657 1.60347616345062 0.5625 13.1 13 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00972348589538422 0.0221030677781657 1.60347616345062 0.5625 13.1 13 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00972348589538422 0.0221030677781657 1.60347616345062 0.5625 13.1 13 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00136748843638025 0.00374218470186366 1.59634960272418 0.56 13.1 13 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00136748843638025 0.00374218470186366 1.59634960272418 0.56 13.1 13 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00136748843638025 0.00374218470186366 1.59634960272418 0.56 13.1 13 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00103302904267426 0.00299389068783192 1.58368016143272 0.555555555555556 13.1 13 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00723982803603173 0.0167675133939874 1.58368016143272 0.555555555555556 13.1 13 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00723982803603173 0.0167675133939874 1.58368016143272 0.555555555555556 13.1 13 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00723982803603173 0.0167675133939874 1.58368016143272 0.555555555555556 13.1 13 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0568499150557235 0.105886687335464 1.58368016143272 0.555555555555556 13.1 13 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0568499150557235 0.105886687335464 1.58368016143272 0.555555555555556 13.1 13 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0568499150557235 0.105886687335464 1.58368016143272 0.555555555555556 13.1 13 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 1.52186355945601e-08 8.29736339121034e-08 1.58368016143272 0.555555555555556 13.1 13 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 7.48050911984766e-15 9.94837801639553e-14 1.56964755240736 0.550632911392405 13.1 13 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00539917027162332 0.0130663593478231 1.56784335981839 0.55 13.1 13 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.91223932056645e-10 2.56549149915487e-09 1.56236139002881 0.548076923076923 13.1 13 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 5.95535608433836e-13 6.0531940771525e-12 1.55861472002874 0.546762589928058 13.1 13 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.57804570956451e-13 4.86161122739575e-12 1.55672390336578 0.546099290780142 13.1 13 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00403257531967667 0.0102287962208554 1.55488597667939 0.545454545454545 13.1 13 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0409430606709474 0.0789457660362577 1.55488597667939 0.545454545454545 13.1 13 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0409430606709474 0.0789457660362577 1.55488597667939 0.545454545454545 13.1 13 1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.0409430606709474 0.0789457660362577 1.55488597667939 0.545454545454545 13.1 13 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0409430606709474 0.0789457660362577 1.55488597667939 0.545454545454545 13.1 13 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0409430606709474 0.0789457660362577 1.55488597667939 0.545454545454545 13.1 13 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.72054001638572e-12 5.87504194829779e-11 1.54685039023661 0.542635658914729 13.1 13 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00301612107910983 0.00781774188629015 1.5440881573969 0.541666666666667 13.1 13 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00301612107910983 0.00781774188629015 1.5440881573969 0.541666666666667 13.1 13 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.72989770270784e-05 6.26372628741286e-05 1.53495154108094 0.538461538461538 13.1 13 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00225880168542473 0.00591947476677603 1.53495154108094 0.538461538461538 13.1 13 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00225880168542473 0.00591947476677603 1.53495154108094 0.538461538461538 13.1 13 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0297307557638289 0.0587595353499007 1.53495154108094 0.538461538461538 13.1 13 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0297307557638289 0.0587595353499007 1.53495154108094 0.538461538461538 13.1 13 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0297307557638289 0.0587595353499007 1.53495154108094 0.538461538461538 13.1 13 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0297307557638289 0.0587595353499007 1.53495154108094 0.538461538461538 13.1 13 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.06485328914154e-21 7.51945901801451e-20 1.52398760150179 0.534615384615385 13.1 13 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0217251541445303 0.0450654436554908 1.52033295497541 0.533333333333333 13.1 13 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0217251541445303 0.0450654436554908 1.52033295497541 0.533333333333333 13.1 13 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 6.33921050949881e-05 0.000212251683647454 1.51628951626537 0.531914893617021 13.1 13 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 1.82170895907098e-07 8.78742999578985e-07 1.51329437648015 0.530864197530864 13.1 13 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.40749004983606e-15 4.8008498424918e-14 1.50915403618882 0.529411764705882 13.1 13 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0159543862097044 0.0349278331944759 1.50915403618882 0.529411764705882 13.1 13 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0159543862097044 0.0349278331944759 1.50915403618882 0.529411764705882 13.1 13 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 2.09373246957837e-05 7.48588267389453e-05 1.50305644412341 0.527272727272727 13.1 13 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 9.17515763631185e-15 1.18693175604289e-13 1.50277476188126 0.527173913043478 13.1 13 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0117639138312593 0.0264874199080411 1.50032857398889 0.526315789473684 13.1 13 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0117639138312593 0.0264874199080411 1.50032857398889 0.526315789473684 13.1 13 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 4.95021436824786e-07 2.21514309623167e-06 1.49840507581711 0.525641025641026 13.1 13 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000307053570219242 0.0009437089209978 1.49657775255392 0.525 13.1 13 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 2.86512754633184e-15 4.16028214125532e-14 1.49042792857678 0.522842639593909 13.1 13 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.02633641676769e-10 7.15919961304129e-10 1.49009906098442 0.522727272727273 13.1 13 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00645701865834624 0.0151622731861827 1.4872822385629 0.521739130434783 13.1 13 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00645701865834624 0.0151622731861827 1.4872822385629 0.521739130434783 13.1 13 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 7.81443746250497e-38 5.85260237323398e-36 1.47869462264111 0.5187265917603 13.1 13 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0035788645314637 0.00917344987775843 1.47810148400387 0.518518518518518 13.1 13 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 5.86529062610299e-07 2.56809494182909e-06 1.47810148400387 0.518518518518518 13.1 13 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00112215501505356 0.00321940844036535 1.46603534944057 0.514285714285714 13.1 13 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.000633077482905989 0.00187290906065535 1.46185861055328 0.512820512820513 13.1 13 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 9.01106525648062e-07 3.90937373779632e-06 1.46007585615016 0.51219512195122 13.1 13 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000476204213149033 0.00144794571647665 1.46007585615016 0.51219512195122 13.1 13 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 5.20407519900126e-07 2.30697788416785e-06 1.45845893936594 0.511627906976744 13.1 13 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 8.76302298340929e-05 0.000289322081331587 1.45220482727604 0.509433962264151 13.1 13 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 6.62291243483146e-05 0.000221230150111858 1.45122691156743 0.509090909090909 13.1 13 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.64419930598578e-05 6.01464167716648e-05 1.44724002444774 0.507692307692308 13.1 13 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.03841881285015e-06 4.46425973016845e-06 1.44208052346932 0.505882352941176 13.1 13 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.03841881285015e-06 4.46425973016845e-06 1.44208052346932 0.505882352941176 13.1 13 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 5.09361551145604e-08 2.60727153697912e-07 1.43863281954449 0.504672897196262 13.1 13 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.8757518962481e-08 1.99825903926125e-07 1.43838840350311 0.504587155963303 13.1 13 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 5.74003595584653e-09 3.28034986552996e-08 1.43690004890968 0.504065040650406 13.1 13 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.29579678961186e-11 3.02619744139489e-10 1.43427637261831 0.50314465408805 13.1 13 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 8.57823664515572e-09 4.74973958990529e-08 1.42531214528944 0.5 13.1 13 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 3.26451218024313e-05 0.000115557234638955 1.42531214528944 0.5 13.1 13 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00170358298744356 0.00455517125429934 1.42531214528944 0.5 13.1 13 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00546407610193019 0.0132009852173967 1.42531214528944 0.5 13.1 13 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00989791623758266 0.0224279216657327 1.42531214528944 0.5 13.1 13 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00989791623758266 0.0224279216657327 1.42531214528944 0.5 13.1 13 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0133738047852496 0.0296431841268072 1.42531214528944 0.5 13.1 13 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0246689443833771 0.0505092199389145 1.42531214528944 0.5 13.1 13 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0337268223936764 0.0659248190469802 1.42531214528944 0.5 13.1 13 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0463812679639279 0.0883541423195039 1.42531214528944 0.5 13.1 13 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.064264434812888 0.119228540728474 1.42531214528944 0.5 13.1 13 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.064264434812888 0.119228540728474 1.42531214528944 0.5 13.1 13 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0073454778653757 0.0169685308481 1.42531214528944 0.5 13.1 13 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0181286573908953 0.0379368815694764 1.42531214528944 0.5 13.1 13 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0181286573908953 0.0379368815694764 1.42531214528944 0.5 13.1 13 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0181286573908953 0.0379368815694764 1.42531214528944 0.5 13.1 13 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0181286573908953 0.0379368815694764 1.42531214528944 0.5 13.1 13 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0899378112533004 0.159379209730319 1.42531214528944 0.5 13.1 13 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0899378112533004 0.159379209730319 1.42531214528944 0.5 13.1 13 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0899378112533004 0.159379209730319 1.42531214528944 0.5 13.1 13 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.0899378112533004 0.159379209730319 1.42531214528944 0.5 13.1 13 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 9.50866302089447e-11 6.66543225553341e-10 1.41645927482181 0.496894409937888 13.1 13 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.63686794489063e-10 1.11447994525329e-09 1.41623372398187 0.496815286624204 13.1 13 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 2.19430966726293e-08 1.1651129315355e-07 1.41353270607218 0.495867768595041 13.1 13 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.09124078369326e-13 2.30684932960892e-12 1.41173774390573 0.495238095238095 13.1 13 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.39732355184671e-12 2.10579716930732e-11 1.41046514377601 0.494791666666667 13.1 13 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 4.00122242548631e-06 1.60387028492029e-05 1.40813970980403 0.493975903614458 13.1 13 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 1.40181790216148e-10 9.7306676818331e-10 1.4077156990513 0.493827160493827 13.1 13 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00106659629930311 0.00308489132908196 1.39216535121295 0.488372093023256 13.1 13 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 4.05292511742897e-05 0.000141355697110329 1.38458894113832 0.485714285714286 13.1 13 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00336302986508479 0.00870107545093755 1.38458894113832 0.485714285714286 13.1 13 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00449523990984924 0.0111635713642504 1.38212086815946 0.484848484848485 13.1 13 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 8.49361922537341e-06 3.18902906535788e-05 1.37500701074982 0.482352941176471 13.1 13 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0108430473897226 0.0244915181517067 1.37252280657502 0.481481481481481 13.1 13 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.63183428749249e-34 3.93212507962576e-32 1.36989565441505 0.480559875583204 13.1 13 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0146017098949818 0.0322643372368931 1.36829965947787 0.48 13.1 13 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0146017098949818 0.0322643372368931 1.36829965947787 0.48 13.1 13 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0197141920682444 0.0411942662453917 1.36334205201599 0.478260869565217 13.1 13 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 4.52222974573946e-09 2.62658486864786e-08 1.36094320969573 0.47741935483871 13.1 13 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00154539844625555 0.00422092512288223 1.36052522959447 0.477272727272727 13.1 13 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.000177096830067158 0.000558777803072209 1.3574401383709 0.476190476190476 13.1 13 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0266972640621972 0.0545836304030267 1.3574401383709 0.476190476190476 13.1 13 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0362834718802831 0.0706311634550517 1.35029571659 0.473684210526316 13.1 13 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0362834718802831 0.0706311634550517 1.35029571659 0.473684210526316 13.1 13 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.000539574390353423 0.00162328616801886 1.34756784645547 0.472727272727273 13.1 13 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 8.68247433217665e-49 1.23551609746874e-46 1.34684150665989 0.472472472472472 13.1 13 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 4.04980534751811e-09 2.36183320062224e-08 1.34661392867837 0.47239263803681 13.1 13 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 8.3284450483765e-05 0.000275613425670692 1.34612813721781 0.472222222222222 13.1 13 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 6.93427373354826e-09 3.878176036849e-08 1.34463409932966 0.471698113207547 13.1 13 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 6.93427373354826e-09 3.878176036849e-08 1.34463409932966 0.471698113207547 13.1 13 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 5.54600536189442e-08 2.80852869394155e-07 1.34386573698719 0.471428571428571 13.1 13 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.000144534436277048 0.000465322404575201 1.34147025439006 0.470588235294118 13.1 13 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00646913766266923 0.015165704932419 1.34147025439006 0.470588235294118 13.1 13 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.001250289717387 0.00349540720597585 1.33804813639417 0.469387755102041 13.1 13 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.84884990047359e-08 1.48494996643733e-07 1.33154160941514 0.467105263157895 13.1 13 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0679553675559011 0.12287228466588 1.33029133560348 0.466666666666667 13.1 13 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0679553675559011 0.12287228466588 1.33029133560348 0.466666666666667 13.1 13 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 0.000117228820850377 0.000382606908417631 1.32768802574907 0.465753424657534 13.1 13 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000760371867226424 0.00222635631082963 1.32350413491163 0.464285714285714 13.1 13 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0155048225058093 0.0340483988051954 1.32350413491163 0.464285714285714 13.1 13 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.42199993694349e-07 6.92981476120066e-07 1.32350413491163 0.464285714285714 13.1 13 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.16210787714198e-35 1.39849068598774e-33 1.32128808346934 0.463508322663252 13.1 13 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.32172674562988e-13 3.55399786393332e-12 1.32050978166522 0.463235294117647 13.1 13 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00132588474738737 0.0036946250658857 1.31567274949795 0.461538461538462 13.1 13 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.02082133734893 0.0433169050402446 1.31567274949795 0.461538461538462 13.1 13 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.02082133734893 0.0433169050402446 1.31567274949795 0.461538461538462 13.1 13 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.02082133734893 0.0433169050402446 1.31567274949795 0.461538461538462 13.1 13 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.093864731140653 0.165104465282014 1.31567274949795 0.461538461538462 13.1 13 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.093864731140653 0.165104465282014 1.31567274949795 0.461538461538462 13.1 13 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.093864731140653 0.165104465282014 1.31567274949795 0.461538461538462 13.1 13 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.093864731140653 0.165104465282014 1.31567274949795 0.461538461538462 13.1 13 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.093864731140653 0.165104465282014 1.31567274949795 0.461538461538462 13.1 13 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000124223305732564 0.000403583936204197 1.31278750224028 0.460526315789474 13.1 13 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.57495384542915e-07 1.21183898773925e-06 1.31251765897157 0.460431654676259 13.1 13 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 1.21222577702151e-05 4.46890487228398e-05 1.31128717366629 0.46 13.1 13 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 3.7062364589694e-11 2.66107601846091e-10 1.30908497464352 0.459227467811159 13.1 13 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.56135281999451e-09 2.63853864343585e-08 1.30848328092146 0.459016393442623 13.1 13 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0280202716172659 0.0568724648652536 1.30653613318199 0.458333333333333 13.1 13 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00908480738695091 0.0209524812182028 1.30314253283606 0.457142857142857 13.1 13 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00405108428927829 0.0102392414629538 1.29573831389949 0.454545454545455 13.1 13 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00405108428927829 0.0102392414629538 1.29573831389949 0.454545454545455 13.1 13 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0121015353891923 0.0271206689290908 1.29573831389949 0.454545454545455 13.1 13 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0378001467929869 0.0734830722492081 1.29573831389949 0.454545454545455 13.1 13 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.130766770071928 0.220534636836277 1.29573831389949 0.454545454545455 13.1 13 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.130766770071928 0.220534636836277 1.29573831389949 0.454545454545455 13.1 13 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.130766770071928 0.220534636836277 1.29573831389949 0.454545454545455 13.1 13 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.130766770071928 0.220534636836277 1.29573831389949 0.454545454545455 13.1 13 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.130766770071928 0.220534636836277 1.29573831389949 0.454545454545455 13.1 13 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.130766770071928 0.220534636836277 1.29573831389949 0.454545454545455 13.1 13 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.130766770071928 0.220534636836277 1.29573831389949 0.454545454545455 13.1 13 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.81449738900522e-64 1.14183829742574e-61 1.29373071418784 0.453841187863137 13.1 13 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00536212816939538 0.012998821780323 1.28956813145235 0.452380952380952 13.1 13 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0161376335927024 0.0352747351803618 1.28737871187434 0.451612903225806 13.1 13 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 5.2279868440565e-06 2.06078262578737e-05 1.27466939822633 0.447154471544715 13.1 13 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.56637799233002e-10 1.07161340532962e-09 1.26694412914617 0.444444444444444 13.1 13 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.56637799233002e-10 1.07161340532962e-09 1.26694412914617 0.444444444444444 13.1 13 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.56637799233002e-10 1.07161340532962e-09 1.26694412914617 0.444444444444444 13.1 13 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0288039693162959 0.0575674836195072 1.26694412914617 0.444444444444444 13.1 13 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0288039693162959 0.0575674836195072 1.26694412914617 0.444444444444444 13.1 13 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0165481651732895 0.0360613155307671 1.25762836349069 0.441176470588235 13.1 13 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 7.2470972170663e-06 2.74789188662195e-05 1.2569681911214 0.440944881889764 13.1 13 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00566124633112002 0.0134714941959595 1.24714812712826 0.4375 13.1 13 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0219659154457054 0.0454985410178148 1.24714812712826 0.4375 13.1 13 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0945775693487424 0.165743696038498 1.24714812712826 0.4375 13.1 13 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0945775693487424 0.165743696038498 1.24714812712826 0.4375 13.1 13 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0945775693487424 0.165743696038498 1.24714812712826 0.4375 13.1 13 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 3.59463742263084e-06 1.44905638878291e-05 1.2446387747598 0.436619718309859 13.1 13 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0517124196581737 0.0979850508303344 1.23940186546908 0.434782608695652 13.1 13 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0517124196581737 0.0979850508303344 1.23940186546908 0.434782608695652 13.1 13 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 4.74734939823973e-06 1.88174880047218e-05 1.23593500710413 0.433566433566434 13.1 13 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.0291761079376547 0.0580665756577379 1.23527052591752 0.433333333333333 13.1 13 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 8.84644575044591e-17 1.46377817475402e-15 1.22831778374537 0.430894308943089 13.1 13 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 4.68566337170856e-13 4.87689764276725e-12 1.22714040316364 0.43048128342246 13.1 13 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.99712177796078e-06 1.21854408286805e-05 1.22430658633837 0.429487179487179 13.1 13 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0387783294241607 0.0752818045983366 1.22169612453381 0.428571428571429 13.1 13 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.129477328523197 0.220534636836277 1.22169612453381 0.428571428571429 13.1 13 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.129477328523197 0.220534636836277 1.22169612453381 0.428571428571429 13.1 13 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.129477328523197 0.220534636836277 1.22169612453381 0.428571428571429 13.1 13 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.129477328523197 0.220534636836277 1.22169612453381 0.428571428571429 13.1 13 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 1.72270566207982e-05 6.25359733964178e-05 1.215707418041 0.426470588235294 13.1 13 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0292344060136623 0.0581013404433539 1.20935575963953 0.424242424242424 13.1 13 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 2.23663406597105e-05 7.97676760871379e-05 1.20683364126697 0.423357664233577 13.1 13 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.48632907109603e-17 2.57932471728006e-16 1.20315315942121 0.422066549912434 13.1 13 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 2.25016285467514e-05 8.0049543555068e-05 1.20133452245825 0.421428571428571 13.1 13 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.07864667283519e-05 4.02295993564399e-05 1.1954230895976 0.419354838709677 13.1 13 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 8.44187497915969e-06 3.17798626860959e-05 1.19369892167991 0.41875 13.1 13 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.15266509211787e-07 1.0279337000281e-06 1.1888253767885 0.417040358744395 13.1 13 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0290537325957245 0.0579040076802744 1.18776012107454 0.416666666666667 13.1 13 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.0290537325957245 0.0579040076802744 1.18776012107454 0.416666666666667 13.1 13 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.178268438114099 0.291917131687415 1.18776012107454 0.416666666666667 13.1 13 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.178268438114099 0.291917131687415 1.18776012107454 0.416666666666667 13.1 13 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 4.75386968522183e-05 0.000164193120438608 1.18602616469341 0.416058394160584 13.1 13 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.28206214058423e-12 2.01700274910022e-11 1.16965077393708 0.410313901345291 13.1 13 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000733475456791547 0.00215203211343169 1.16875595913734 0.41 13.1 13 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0913910881264212 0.161753132343156 1.16616448250954 0.409090909090909 13.1 13 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.61534945587227e-05 0.000127342630586788 1.16203792736974 0.407643312101911 13.1 13 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00959061310449797 0.0219060071391663 1.15957598260836 0.406779661016949 13.1 13 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0499690622377021 0.0949345468147532 1.15806611804767 0.40625 13.1 13 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0654535361588508 0.121276539002662 1.14024971623156 0.4 13.1 13 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.121742279962401 0.210241825711768 1.14024971623156 0.4 13.1 13 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.170491969168061 0.280150198759989 1.14024971623156 0.4 13.1 13 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 0.000664531396502835 0.0019578223130922 1.13082616485774 0.396694214876033 13.1 13 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 0.000664531396502835 0.0019578223130922 1.13082616485774 0.396694214876033 13.1 13 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.047394571859826 0.0901637376424231 1.12524643049167 0.394736842105263 13.1 13 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0634465887833281 0.118018948808727 1.12297320537956 0.393939393939394 13.1 13 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00393514796013114 0.00999949204869038 1.12103202438496 0.393258426966292 13.1 13 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0856380776551859 0.152519379853979 1.11988811415599 0.392857142857143 13.1 13 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.0856380776551859 0.152519379853979 1.11988811415599 0.392857142857143 13.1 13 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0346012273667055 0.0675412161081234 1.11546167892217 0.391304347826087 13.1 13 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 4.6497735748139e-05 0.000160988510874944 1.11352511350738 0.390625 13.1 13 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.162200110525164 0.270904644691676 1.1085761130029 0.388888888888889 13.1 13 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00630328317495275 0.0148502846986056 1.1067129598718 0.388235294117647 13.1 13 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00630328317495275 0.0148502846986056 1.1067129598718 0.388235294117647 13.1 13 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00630328317495275 0.0148502846986056 1.1067129598718 0.388235294117647 13.1 13 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00630328317495275 0.0148502846986056 1.1067129598718 0.388235294117647 13.1 13 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00630328317495275 0.0148502846986056 1.1067129598718 0.388235294117647 13.1 13 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00612813108647096 0.0145581478064243 1.10137756681457 0.386363636363636 13.1 13 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.231020754972503 0.366900149917268 1.09639395791496 0.384615384615385 13.1 13 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.231020754972503 0.366900149917268 1.09639395791496 0.384615384615385 13.1 13 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.231020754972503 0.366900149917268 1.09639395791496 0.384615384615385 13.1 13 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.0100320298423167 0.0226956732362746 1.09097966676476 0.382716049382716 13.1 13 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00724667655467482 0.0167675133939874 1.08447663228545 0.380434782608696 13.1 13 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.216040609059652 0.346590514872474 1.06898410896708 0.375 13.1 13 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.216040609059652 0.346590514872474 1.06898410896708 0.375 13.1 13 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.138139823251348 0.232355754712374 1.05578677428848 0.37037037037037 13.1 13 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.0663197609558865 0.122246505912885 1.05349158564872 0.369565217391304 13.1 13 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.202274981109477 0.326346142991821 1.05023000179222 0.368421052631579 13.1 13 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0162726409538367 0.0355152884621314 1.04522890654559 0.366666666666667 13.1 13 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.130801991208586 0.220534636836277 1.04522890654559 0.366666666666667 13.1 13 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.130801991208586 0.220534636836277 1.04522890654559 0.366666666666667 13.1 13 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.117290818960573 0.202800529016884 1.02939210493127 0.361111111111111 13.1 13 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.111098782800912 0.194457033118939 1.02330102738729 0.358974358974359 13.1 13 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.287433769666562 0.429190193321635 1.01808010377817 0.357142857142857 13.1 13 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.287433769666562 0.429190193321635 1.01808010377817 0.357142857142857 13.1 13 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.287433769666562 0.429190193321635 1.01808010377817 0.357142857142857 13.1 13 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.287433769666562 0.429190193321635 1.01808010377817 0.357142857142857 13.1 13 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.287433769666562 0.429190193321635 1.01808010377817 0.357142857142857 13.1 13 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.157413064369328 0.263527988938299 1.01151184504412 0.354838709677419 13.1 13 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.157413064369328 0.263527988938299 1.01151184504412 0.354838709677419 13.1 13 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.265091111739138 0.407370034562411 1.00610269079255 0.352941176470588 13.1 13 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.139745538219685 0.234779103762233 1.00157069668988 0.351351351351351 13.1 13 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.131836384748702 0.222015592304619 0.997718501702611 0.35 13.1 13 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.245638743265595 0.388814162032194 0.997718501702611 0.35 13.1 13 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.245638743265595 0.388814162032194 0.997718501702611 0.35 13.1 13 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.21303247730468 0.342924451588869 0.986754562123461 0.346153846153846 13.1 13 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0283762825399368 0.0568724648652536 0.984761118563616 0.345454545454545 13.1 13 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.186497769831428 0.301233060692533 0.979902099886493 0.34375 13.1 13 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.186497769831428 0.301233060692533 0.979902099886493 0.34375 13.1 13 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.94786936566417e-05 6.99954067510129e-05 0.979002281612951 0.343434343434343 13.1 13 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0034748621921873 0.00897409963608445 0.961387015646213 0.337254901960784 13.1 13 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.158490864801538 0.265020564762149 0.950208096859629 0.333333333333333 13.1 13 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.217819616302484 0.348054725334812 0.950208096859629 0.333333333333333 13.1 13 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.217819616302484 0.348054725334812 0.950208096859629 0.333333333333333 13.1 13 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.217819616302484 0.348054725334812 0.950208096859629 0.333333333333333 13.1 13 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.250478804331347 0.393846782943101 0.950208096859629 0.333333333333333 13.1 13 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.168452137161936 0.277118371308017 0.950208096859629 0.333333333333333 13.1 13 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.345904669915814 0.509101447481705 0.950208096859629 0.333333333333333 13.1 13 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.345904669915814 0.509101447481705 0.950208096859629 0.333333333333333 13.1 13 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.181437841743638 0.296765573334709 0.930816094882902 0.326530612244898 13.1 13 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.205923297185839 0.331856004411608 0.912199772985244 0.32 13.1 13 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.369272749839962 0.542846201469283 0.900197144393333 0.315789473684211 13.1 13 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.217931665687504 0.348054725334812 0.897418758145205 0.314814814814815 13.1 13 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.285989864511492 0.429190193321635 0.895910491324793 0.314285714285714 13.1 13 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.24687651470382 0.389520390923351 0.890820090805902 0.3125 13.1 13 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.404933788486796 0.579116362830865 0.890820090805902 0.3125 13.1 13 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.151687501182997 0.254541644084203 0.888904348675137 0.311827956989247 13.1 13 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.215886057130976 0.346590514872474 0.887899369196703 0.311475409836066 13.1 13 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.18619160016493 0.301233060692533 0.874623361882159 0.306818181818182 13.1 13 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.172182793575707 0.282602209063704 0.868761688557375 0.304761904761905 13.1 13 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.293946880903282 0.43845535799305 0.867581305828357 0.304347826086957 13.1 13 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.387430730804446 0.556058744644998 0.867581305828357 0.304347826086957 13.1 13 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.219198994942492 0.349686289017003 0.86601244270751 0.30379746835443 13.1 13 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.345960013854398 0.509101447481705 0.863825542599663 0.303030303030303 13.1 13 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.345960013854398 0.509101447481705 0.863825542599663 0.303030303030303 13.1 13 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.345960013854398 0.509101447481705 0.863825542599663 0.303030303030303 13.1 13 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.231653333430106 0.36749464155077 0.862688930043611 0.302631578947368 13.1 13 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.422258752657547 0.602682251787051 0.855187287173666 0.3 13.1 13 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.422258752657547 0.602682251787051 0.855187287173666 0.3 13.1 13 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.259103945934358 0.401685288855395 0.855187287173666 0.3 13.1 13 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.305670754749457 0.455465428281128 0.855187287173666 0.3 13.1 13 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.372459105488982 0.546965229216534 0.855187287173666 0.3 13.1 13 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.230805655376037 0.366900149917268 0.849122129108605 0.297872340425532 13.1 13 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.402198698270838 0.575783448329379 0.844629419430782 0.296296296296296 13.1 13 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.447127874757389 0.624405266361469 0.814464083022539 0.285714285714286 13.1 13 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.249649331205911 0.392976768037623 0.812096454874218 0.284883720930233 13.1 13 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.399654537416292 0.572717428744596 0.806780459597798 0.283018867924528 13.1 13 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.434657202787256 0.614828230185154 0.804022235804302 0.282051282051282 13.1 13 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.434657202787256 0.614828230185154 0.804022235804302 0.282051282051282 13.1 13 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.483745195719583 0.665153992654396 0.798174801362089 0.28 13.1 13 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.483745195719583 0.665153992654396 0.798174801362089 0.28 13.1 13 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.483745195719583 0.665153992654396 0.798174801362089 0.28 13.1 13 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.519611169741473 0.696896036326217 0.791840080716358 0.277777777777778 13.1 13 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.491477365543067 0.667977355461112 0.786379114642452 0.275862068965517 13.1 13 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.525381937535249 0.703972219503446 0.777442988339697 0.272727272727273 13.1 13 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.493421788143147 0.669980156992078 0.757760887369071 0.265822784810127 13.1 13 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.518757104266417 0.696406942802935 0.756288077092358 0.26530612244898 13.1 13 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.538743800678104 0.720519199591111 0.754577018094411 0.264705882352941 13.1 13 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.335456950247596 0.49880380376419 0.752286703025941 0.26390243902439 13.1 13 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.573303462563441 0.761128701892225 0.750164286994444 0.263157894736842 13.1 13 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.50851580406062 0.686544581763057 0.747704731955118 0.262295081967213 13.1 13 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.545804491088223 0.729276798890649 0.746592076103994 0.261904761904762 13.1 13 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.574070598734356 0.761128701892225 0.743641119281449 0.260869565217391 13.1 13 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.53248963000428 0.712824782216454 0.740713398339396 0.259842519685039 13.1 13 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.585974659229071 0.771361646700248 0.725613455783717 0.254545454545455 13.1 13 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.615378775232856 0.798253415821654 0.712656072644722 0.25 13.1 13 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.617895833370515 0.800788498074902 0.712656072644722 0.25 13.1 13 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.620127261423135 0.802949129213032 0.712656072644722 0.25 13.1 13 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.645283938138069 0.832492333608769 0.704271883554784 0.247058823529412 13.1 13 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.645283938138069 0.832492333608769 0.704271883554784 0.247058823529412 13.1 13 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.651577535121241 0.839850391736889 0.693395097708378 0.243243243243243 13.1 13 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.654376733440521 0.841801435639455 0.69106043407973 0.242424242424242 13.1 13 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.689493659610794 0.874118425462904 0.690151144034889 0.242105263157895 13.1 13 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.671911876045267 0.857516232836246 0.689667167075537 0.241935483870968 13.1 13 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.658119891315612 0.842938438651769 0.688081725312145 0.241379310344828 13.1 13 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.663195282171625 0.847151603707561 0.684149829738933 0.24 13.1 13 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.663195282171625 0.847151603707561 0.684149829738933 0.24 13.1 13 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.663195282171625 0.847151603707561 0.684149829738933 0.24 13.1 13 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.685458654847407 0.870899701649875 0.675147858295 0.236842105263158 13.1 13 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.823954395285978 0.994489998292469 0.662577537810228 0.232432432432432 13.1 13 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.74279971638672 0.919133909928959 0.661014328250177 0.231884057971014 13.1 13 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.748972603455832 0.92436081068313 0.654241640460728 0.229508196721311 13.1 13 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.909759346374525 1 0.641104258122159 0.224899598393574 13.1 13 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.739575762535643 0.915941087979304 0.633472064573086 0.222222222222222 13.1 13 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.739575762535643 0.915941087979304 0.633472064573086 0.222222222222222 13.1 13 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.774193715050479 0.948263530060712 0.625746795492927 0.219512195121951 13.1 13 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.812135183281627 0.986065158540747 0.623574063564132 0.21875 13.1 13 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.751397903880558 0.926550448199337 0.619700932734541 0.217391304347826 13.1 13 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.81481224317691 0.988472141552211 0.606515806506146 0.212765957446809 13.1 13 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.847431221945129 1 0.591639003705052 0.207547169811321 13.1 13 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.847431221945129 1 0.591639003705052 0.207547169811321 13.1 13 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.802667625531249 0.97584366336239 0.589784335981839 0.206896551724138 13.1 13 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.817643681964978 0.990218688881841 0.586893236295653 0.205882352941176 13.1 13 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.816629691695102 0.989833093085289 0.570124858115778 0.2 13.1 13 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.829418231809494 0.996843026912931 0.570124858115778 0.2 13.1 13 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.829418231809494 0.996843026912931 0.570124858115778 0.2 13.1 13 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.841273797299877 1 0.570124858115777 0.2 13.1 13 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.871122249221685 1 0.55621937377149 0.195121951219512 13.1 13 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.853180763638887 1 0.55173373366043 0.193548387096774 13.1 13 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.853180763638887 1 0.55173373366043 0.193548387096774 13.1 13 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.843672792226106 1 0.548196978957478 0.192307692307692 13.1 13 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.999391026825309 1 0.503051345396274 0.176470588235294 13.1 13 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.986409861699307 1 0.493377281061731 0.173076923076923 13.1 13 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.997482013500228 1 0.486691952050054 0.170731707317073 13.1 13 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999089325932801 1 0.475104048429815 0.166666666666667 13.1 13 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.944906988469145 1 0.462263398472252 0.162162162162162 13.1 13 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.992856954792926 1 0.460706956053154 0.161616161616162 13.1 13 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.933910781518135 1 0.459778111383692 0.161290322580645 13.1 13 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.976717782331091 1 0.450098572196666 0.157894736842105 13.1 13 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.96130089527306 1 0.438557583165983 0.153846153846154 13.1 13 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999953725195281 1 0.433505076447481 0.152073732718894 13.1 13 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.980757411003223 1 0.415716042376088 0.145833333333333 13.1 13 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.991602878100268 1 0.40723204151127 0.142857142857143 13.1 13 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.392529289382819 0.137699412258606 13.1 13 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.999156689582087 1 0.38204243069614 0.134020618556701 13.1 13 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99999999997048 1 0.360001521232901 0.126288659793814 13.1 13 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.309290158109825 0.108499095840868 13.1 13 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999999948173 1 0.305424031133452 0.107142857142857 13.1 13 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.997427244256775 1 0.303257903253073 0.106382978723404 13.1 13 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.999813211219152 1 0.281047465268341 0.0985915492957746 13.1 13 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999996800534839 1 0.263946693572119 0.0925925925925926 13.1 13 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999996116259 1 0.259147662779899 0.0909090909090909 13.1 13 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.128737871187434 0.0451612903225806 13.1 13 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 5.15287131347147e-06 2.1315511276366e-05 1.0462030279269 1 14.3 14 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 5.15287131347147e-06 2.1315511276366e-05 1.0462030279269 1 14.3 14 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.66824923388686e-08 9.97444815050841e-08 1.0462030279269 1 14.3 14 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 1.432294120879e-07 7.74963701144797e-07 1.0462030279269 1 14.3 14 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 2.93266503081053e-07 1.47462273457363e-06 1.0462030279269 1 14.3 14 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 2.93266503081053e-07 1.47462273457363e-06 1.0462030279269 1 14.3 14 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 6.00453380062806e-07 2.90627605384141e-06 1.0462030279269 1 14.3 14 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 6.00453380062806e-07 2.90627605384141e-06 1.0462030279269 1 14.3 14 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 6.00453380062806e-07 2.90627605384141e-06 1.0462030279269 1 14.3 14 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 1.22937028085927e-06 5.4839934472186e-06 1.0462030279269 1 14.3 14 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 1.05490285876466e-05 4.18141161008944e-05 1.0462030279269 1 14.3 14 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 1.05490285876466e-05 4.18141161008944e-05 1.0462030279269 1 14.3 14 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 1.05490285876466e-05 4.18141161008944e-05 1.0462030279269 1 14.3 14 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 2.15954485860002e-05 8.10826473294943e-05 1.0462030279269 1 14.3 14 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 2.15954485860002e-05 8.10826473294943e-05 1.0462030279269 1 14.3 14 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 2.15954485860002e-05 8.10826473294943e-05 1.0462030279269 1 14.3 14 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 4.42077670722166e-05 0.000160889136940574 1.0462030279269 1 14.3 14 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 9.04943612933683e-05 0.00031409179367458 1.0462030279269 1 14.3 14 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 9.04943612933683e-05 0.00031409179367458 1.0462030279269 1 14.3 14 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 9.04943612933683e-05 0.00031409179367458 1.0462030279269 1 14.3 14 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000185238412517698 0.000602977733490355 1.0462030279269 1 14.3 14 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000185238412517698 0.000602977733490355 1.0462030279269 1 14.3 14 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000185238412517698 0.000602977733490355 1.0462030279269 1 14.3 14 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000185238412517698 0.000602977733490355 1.0462030279269 1 14.3 14 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000185238412517698 0.000602977733490355 1.0462030279269 1 14.3 14 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000185238412517698 0.000602977733490355 1.0462030279269 1 14.3 14 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00037916406830714 0.0011431154008497 1.0462030279269 1 14.3 14 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00037916406830714 0.0011431154008497 1.0462030279269 1 14.3 14 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00037916406830714 0.0011431154008497 1.0462030279269 1 14.3 14 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00037916406830714 0.0011431154008497 1.0462030279269 1 14.3 14 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000776086077166295 0.00220874097561527 1.0462030279269 1 14.3 14 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.000776086077166295 0.00220874097561527 1.0462030279269 1 14.3 14 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.000776086077166295 0.00220874097561527 1.0462030279269 1 14.3 14 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000776086077166295 0.00220874097561527 1.0462030279269 1 14.3 14 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00158847068841852 0.00413234696456957 1.0462030279269 1 14.3 14 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00325113583177857 0.00773639847595468 1.0462030279269 1 14.3 14 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00665392071001892 0.0146798901865999 1.0462030279269 1 14.3 14 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0136177929549521 0.027842125538645 1.0462030279269 1 14.3 14 3 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 G2 PHASE%REACTOME%REACT_227891.1 G2 PHASE 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604677 HISTIDINE CATABOLISM 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0278690671677942 0.0521811612891726 1.0462030279269 1 14.3 14 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.50245822445405e-08 9.0593137855852e-08 1.01132959366267 0.966666666666667 14.3 14 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 5.89393660081607e-08 3.26345205562695e-07 1.00883863407236 0.964285714285714 14.3 14 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 4.53646898285224e-07 2.23370081750821e-06 1.00435490680982 0.96 14.3 14 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.48214994966429e-12 1.93495355813971e-11 1.00261123509661 0.958333333333333 14.3 14 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 8.93098591355062e-07 4.07333107531491e-06 1.00261123509661 0.958333333333333 14.3 14 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 8.93098591355062e-07 4.07333107531491e-06 1.00261123509661 0.958333333333333 14.3 14 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 8.93098591355062e-07 4.07333107531491e-06 1.00261123509661 0.958333333333333 14.3 14 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 2.91285606735964e-12 3.70088766415425e-11 1.00168375014277 0.957446808510638 14.3 14 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.75537357345366e-06 7.66225949394034e-06 1.00071593975616 0.956521739130435 14.3 14 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 3.44404541393725e-06 1.45426606054383e-05 0.998648344839309 0.954545454545455 14.3 14 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 3.44404541393725e-06 1.45426606054383e-05 0.998648344839309 0.954545454545455 14.3 14 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 4.30397641211077e-11 3.56078978746141e-10 0.997542421976807 0.953488372093023 14.3 14 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 6.74419091969786e-06 2.75775393066955e-05 0.996383836120853 0.952380952380952 14.3 14 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 1.3178791395992e-05 5.13792333054702e-05 0.993892876530551 0.95 14.3 14 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 2.56931781975658e-05 9.59616603021944e-05 0.991139710667585 0.947368421052632 14.3 14 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.5856531787437e-09 2.86201073392644e-08 0.988080637486512 0.944444444444444 14.3 14 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 4.5856531787437e-09 2.86201073392644e-08 0.988080637486512 0.944444444444444 14.3 14 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 1.71859686722339e-08 1.02125150529585e-07 0.984661673342961 0.941176470588235 14.3 14 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 9.68875449744488e-05 0.000334638292472429 0.984661673342961 0.941176470588235 14.3 14 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.2654800770292e-11 1.20051876640837e-10 0.982149781319126 0.938775510204082 14.3 14 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.000187291748561305 0.000602977733490355 0.980815338681465 0.9375 14.3 14 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.23068171269172e-07 6.68419876778746e-07 0.978706058383225 0.935483870967742 14.3 14 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.36281872221028e-07 1.21822139192218e-06 0.976456159398436 0.933333333333333 14.3 14 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000360780225879246 0.0010969877380901 0.976456159398436 0.933333333333333 14.3 14 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000360780225879246 0.0010969877380901 0.976456159398436 0.933333333333333 14.3 14 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000360780225879246 0.0010969877380901 0.976456159398436 0.933333333333333 14.3 14 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000360780225879246 0.0010969877380901 0.976456159398436 0.933333333333333 14.3 14 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000360780225879246 0.0010969877380901 0.976456159398436 0.933333333333333 14.3 14 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000360780225879246 0.0010969877380901 0.976456159398436 0.933333333333333 14.3 14 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000360780225879246 0.0010969877380901 0.976456159398436 0.933333333333333 14.3 14 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.53204554887827e-13 3.79273770110925e-12 0.975274009084394 0.932203389830508 14.3 14 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.53204554887827e-13 3.79273770110925e-12 0.975274009084394 0.932203389830508 14.3 14 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 4.52657385838199e-07 2.23370081750821e-06 0.97405109496642 0.931034482758621 14.3 14 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 6.32486247300416e-10 4.36906762091501e-09 0.973212119001763 0.930232558139535 14.3 14 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.69401408958107e-21 8.31235189473746e-20 0.972968815972013 0.93 14.3 14 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.000692220086168339 0.00198995794468191 0.971474240217832 0.928571428571429 14.3 14 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000692220086168339 0.00198995794468191 0.971474240217832 0.928571428571429 14.3 14 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000692220086168339 0.00198995794468191 0.971474240217832 0.928571428571429 14.3 14 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000692220086168339 0.00198995794468191 0.971474240217832 0.928571428571429 14.3 14 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000692220086168339 0.00198995794468191 0.971474240217832 0.928571428571429 14.3 14 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 6.17216491712251e-21 2.74468458658292e-19 0.971474240217831 0.928571428571429 14.3 14 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.20739589052169e-09 8.1815445343446e-09 0.971474240217831 0.928571428571429 14.3 14 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.30090444895698e-09 1.48153259315194e-08 0.969651586859074 0.926829268292683 14.3 14 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.30090444895698e-09 1.48153259315194e-08 0.969651586859074 0.926829268292683 14.3 14 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.30090444895698e-09 1.48153259315194e-08 0.969651586859074 0.926829268292683 14.3 14 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.64948638334968e-06 7.22221268771258e-06 0.968706507339718 0.925925925925926 14.3 14 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 1.64948638334968e-06 7.22221268771258e-06 0.968706507339718 0.925925925925926 14.3 14 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.82560272071099e-14 3.41820088364703e-13 0.96812817509653 0.925373134328358 14.3 14 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.82560272071099e-14 3.41820088364703e-13 0.96812817509653 0.925373134328358 14.3 14 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 4.37684907836684e-09 2.75586559226372e-08 0.967737800832378 0.925 14.3 14 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 3.13645547319314e-06 1.33628028094426e-05 0.965725871932519 0.923076923076923 14.3 14 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 3.13645547319314e-06 1.33628028094426e-05 0.965725871932519 0.923076923076923 14.3 14 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 3.13645547319314e-06 1.33628028094426e-05 0.965725871932519 0.923076923076923 14.3 14 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00132216702720966 0.00357688912494172 0.965725871932519 0.923076923076923 14.3 14 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00132216702720966 0.00357688912494172 0.965725871932519 0.923076923076923 14.3 14 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00132216702720966 0.00357688912494172 0.965725871932519 0.923076923076923 14.3 14 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.05250000669967e-18 3.65294514520397e-17 0.964831681310359 0.922222222222222 14.3 14 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.37334907027117e-11 3.57659524539993e-10 0.964147888481649 0.92156862745098 14.3 14 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.37334907027117e-11 3.57659524539993e-10 0.964147888481649 0.92156862745098 14.3 14 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.28983256065917e-15 3.00121365695426e-14 0.962506785692744 0.92 14.3 14 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 5.9467930616582e-06 2.44574755108081e-05 0.962506785692744 0.92 14.3 14 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 5.9467930616582e-06 2.44574755108081e-05 0.962506785692744 0.92 14.3 14 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.95848722850837e-20 1.56328653712406e-18 0.96166136910452 0.919191919191919 14.3 14 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.97735485422661e-08 1.71529390994513e-07 0.961375755392282 0.918918918918919 14.3 14 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.97735485422661e-08 1.71529390994513e-07 0.961375755392282 0.918918918918919 14.3 14 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 5.61731908361257e-08 3.12243947499245e-07 0.959019442266321 0.916666666666667 14.3 14 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 5.61731908361257e-08 3.12243947499245e-07 0.959019442266321 0.916666666666667 14.3 14 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 1.12403983765382e-05 4.44307969161494e-05 0.959019442266321 0.916666666666667 14.3 14 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.002512346281991 0.00626106612832433 0.959019442266321 0.916666666666667 14.3 14 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.77792570511568e-17 1.25907190340363e-15 0.959019442266321 0.916666666666667 14.3 14 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.77792570511568e-17 1.25907190340363e-15 0.959019442266321 0.916666666666667 14.3 14 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.78865918360828e-21 1.29549065460445e-19 0.958204642400334 0.91588785046729 14.3 14 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 1.05733744907344e-07 5.76471720318586e-07 0.956528482676019 0.914285714285714 14.3 14 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 2.11750997390151e-05 8.01387418314323e-05 0.955228851585426 0.91304347826087 14.3 14 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.28628519431479e-30 1.3074170225071e-28 0.954660262983292 0.9125 14.3 14 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.98530187708245e-07 1.03105276317092e-06 0.953890996050993 0.911764705882353 14.3 14 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.11529615899867e-15 2.68973456732442e-14 0.953501493806791 0.911392405063291 14.3 14 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.95089300177692e-09 1.29121894954816e-08 0.953207203222283 0.911111111111111 14.3 14 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.01569836558112e-13 3.08423524109886e-12 0.952513204530457 0.91044776119403 14.3 14 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.64956983730532e-09 2.30815016821576e-08 0.951093661751723 0.909090909090909 14.3 14 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 3.97456459773041e-05 0.000145020651860779 0.951093661751723 0.909090909090909 14.3 14 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00474530616575785 0.0109264897635492 0.951093661751723 0.909090909090909 14.3 14 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 7.27918213579604e-15 1.45891213792081e-13 0.949842222723102 0.907894736842105 14.3 14 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.64461856308763e-22 8.35818648312036e-21 0.949495185009283 0.907563025210084 14.3 14 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 6.86502534926876e-11 5.34039171270425e-10 0.949332377192924 0.907407407407407 14.3 14 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 6.86502534926876e-11 5.34039171270425e-10 0.949332377192924 0.907407407407407 14.3 14 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.90768969539826e-20 1.25383104137931e-18 0.948427044008494 0.906542056074766 14.3 14 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 6.94354266707557e-07 3.3493766831351e-06 0.948121494058749 0.90625 14.3 14 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.62310251080996e-31 3.39334079352962e-29 0.9477368605926 0.905882352941176 14.3 14 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.1236468232414e-23 6.95195404118484e-22 0.94734919851648 0.905511811023622 14.3 14 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.52581102324872e-14 4.60798600779864e-13 0.947237876636513 0.905405405405405 14.3 14 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.52581102324872e-14 4.60798600779864e-13 0.947237876636513 0.905405405405405 14.3 14 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.88648995784102e-31 5.79456267500647e-29 0.947154220549201 0.905325443786982 14.3 14 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.43805391904274e-12 3.15395520617984e-11 0.94656464431481 0.904761904761905 14.3 14 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.26892357540924e-08 7.7165737085784e-08 0.94656464431481 0.904761904761905 14.3 14 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 7.43074959207864e-05 0.000261085349864887 0.94656464431481 0.904761904761905 14.3 14 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 7.43074959207864e-05 0.000261085349864887 0.94656464431481 0.904761904761905 14.3 14 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 7.43074959207864e-05 0.000261085349864887 0.94656464431481 0.904761904761905 14.3 14 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 7.43074959207864e-05 0.000261085349864887 0.94656464431481 0.904761904761905 14.3 14 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 9.10749001310196e-16 2.2344755670076e-14 0.945364181861653 0.903614457831325 14.3 14 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 4.52900113915628e-12 5.5240956541673e-11 0.944957573611389 0.903225806451613 14.3 14 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.68985330973013e-15 3.81692263451742e-14 0.944134439836467 0.902439024390244 14.3 14 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.35793369004079e-08 1.38079820614323e-07 0.944134439836467 0.902439024390244 14.3 14 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.35793369004079e-08 1.38079820614323e-07 0.944134439836467 0.902439024390244 14.3 14 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 4.41412064045594e-10 3.1095513224598e-09 0.943634103620337 0.901960784313726 14.3 14 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.01448808792611e-29 1.68624502889344e-27 0.94350825217947 0.901840490797546 14.3 14 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 8.39923160254801e-12 8.02154803384283e-11 0.943297812065234 0.901639344262295 14.3 14 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 8.39923160254801e-12 8.02154803384283e-11 0.943297812065234 0.901639344262295 14.3 14 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.61567062117531e-13 2.52648274058512e-12 0.943056250525652 0.901408450704225 14.3 14 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.26776141226487e-51 3.60804897930582e-49 0.942653922773721 0.901023890784983 14.3 14 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.2085596016125e-18 7.48281026927282e-17 0.941582725134206 0.9 14.3 14 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.55500153430314e-11 1.4557678837588e-10 0.941582725134206 0.9 14.3 14 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 2.40003700839274e-06 1.03807071821972e-05 0.941582725134206 0.9 14.3 14 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00013832265941173 0.000469768840913822 0.941582725134206 0.9 14.3 14 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00013832265941173 0.000469768840913822 0.941582725134206 0.9 14.3 14 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00889993218968857 0.0189589872843216 0.941582725134206 0.9 14.3 14 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 9.28691765458592e-74 3.30382095561894e-71 0.940600374873242 0.89906103286385 14.3 14 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 2.87376425080419e-11 2.60469205662061e-10 0.939809499663143 0.898305084745763 14.3 14 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 5.30119903692023e-11 4.19089234974305e-10 0.937975128486182 0.896551724137931 14.3 14 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 5.30119903692023e-11 4.19089234974305e-10 0.937975128486182 0.896551724137931 14.3 14 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 5.30119903692023e-11 4.19089234974305e-10 0.937975128486182 0.896551724137931 14.3 14 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 5.30119903692023e-11 4.19089234974305e-10 0.937975128486182 0.896551724137931 14.3 14 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 4.44023862830097e-06 1.84750279768195e-05 0.937975128486182 0.896551724137931 14.3 14 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 4.44023862830097e-06 1.84750279768195e-05 0.937975128486182 0.896551724137931 14.3 14 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 4.44023862830097e-06 1.84750279768195e-05 0.937975128486182 0.896551724137931 14.3 14 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.30762647035252e-15 3.00121365695426e-14 0.936716664539197 0.895348837209302 14.3 14 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.40201334376576e-23 1.36722599527147e-21 0.936076393408275 0.894736842105263 14.3 14 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000256263312273536 0.000812166354933723 0.936076393408275 0.894736842105263 14.3 14 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000256263312273536 0.000812166354933723 0.936076393408275 0.894736842105263 14.3 14 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.23158385082131e-13 2.03784165083573e-12 0.93460803828136 0.893333333333333 14.3 14 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.23158385082131e-13 2.03784165083573e-12 0.93460803828136 0.893333333333333 14.3 14 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.23158385082131e-13 2.03784165083573e-12 0.93460803828136 0.893333333333333 14.3 14 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.23158385082131e-13 2.03784165083573e-12 0.93460803828136 0.893333333333333 14.3 14 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.23158385082131e-13 2.03784165083573e-12 0.93460803828136 0.893333333333333 14.3 14 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.79355768919753e-10 1.32240030659486e-09 0.9341098463633 0.892857142857143 14.3 14 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 8.1854913260061e-06 3.30907788548485e-05 0.9341098463633 0.892857142857143 14.3 14 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 8.1854913260061e-06 3.30907788548485e-05 0.9341098463633 0.892857142857143 14.3 14 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 8.1854913260061e-06 3.30907788548485e-05 0.9341098463633 0.892857142857143 14.3 14 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 8.1854913260061e-06 3.30907788548485e-05 0.9341098463633 0.892857142857143 14.3 14 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 4.87031505450712e-44 9.90065474651947e-42 0.933966687766156 0.89272030651341 14.3 14 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.68419167943337e-87 5.24260475983368e-84 0.932831216915806 0.891634980988593 14.3 14 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 9.41421085783048e-09 5.7993169050618e-08 0.932485307500059 0.891304347826087 14.3 14 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.80352016757941e-19 1.38779723037577e-17 0.932071788516689 0.890909090909091 14.3 14 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.28907231459481e-10 2.351934624959e-09 0.932071788516689 0.890909090909091 14.3 14 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.28907231459481e-10 2.351934624959e-09 0.932071788516689 0.890909090909091 14.3 14 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.28907231459481e-10 2.351934624959e-09 0.932071788516689 0.890909090909091 14.3 14 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.28907231459481e-10 2.351934624959e-09 0.932071788516689 0.890909090909091 14.3 14 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.28907231459481e-10 2.351934624959e-09 0.932071788516689 0.890909090909091 14.3 14 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.28907231459481e-10 2.351934624959e-09 0.932071788516689 0.890909090909091 14.3 14 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 7.56806598546866e-13 1.07693578973219e-11 0.929958247046129 0.888888888888889 14.3 14 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 2.1256578900065e-11 1.96416310225925e-10 0.929958247046129 0.888888888888889 14.3 14 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 5.02218177477095e-07 2.45586414621961e-06 0.929958247046129 0.888888888888889 14.3 14 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000472278155757115 0.00140303093035986 0.929958247046129 0.888888888888889 14.3 14 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000472278155757115 0.00140303093035986 0.929958247046129 0.888888888888889 14.3 14 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000472278155757115 0.00140303093035986 0.929958247046129 0.888888888888889 14.3 14 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000472278155757115 0.00140303093035986 0.929958247046129 0.888888888888889 14.3 14 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0165524569786589 0.0328052176610468 0.929958247046129 0.888888888888889 14.3 14 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0165524569786589 0.0328052176610468 0.929958247046129 0.888888888888889 14.3 14 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0165524569786589 0.0328052176610468 0.929958247046129 0.888888888888889 14.3 14 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0165524569786589 0.0328052176610468 0.929958247046129 0.888888888888889 14.3 14 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0165524569786589 0.0328052176610468 0.929958247046129 0.888888888888889 14.3 14 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0165524569786589 0.0328052176610468 0.929958247046129 0.888888888888889 14.3 14 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0165524569786589 0.0328052176610468 0.929958247046129 0.888888888888889 14.3 14 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 6.01885015076095e-10 4.17796281196723e-09 0.929958247046129 0.888888888888889 14.3 14 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.50322081919408e-05 5.81272615682927e-05 0.929958247046129 0.888888888888889 14.3 14 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 1.50322081919408e-05 5.81272615682927e-05 0.929958247046129 0.888888888888889 14.3 14 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 1.50322081919408e-05 5.81272615682927e-05 0.929958247046129 0.888888888888889 14.3 14 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.09900884393836e-09 7.48272528671906e-09 0.927764949293662 0.886792452830189 14.3 14 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.51797706437668e-12 3.22800122757479e-11 0.926636967592393 0.885714285714286 14.3 14 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 9.17702619415216e-07 4.15624658443719e-06 0.926636967592393 0.885714285714286 14.3 14 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 9.17702619415216e-07 4.15624658443719e-06 0.926636967592393 0.885714285714286 14.3 14 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 7.07132041981892e-11 5.46874399858822e-10 0.926146942754957 0.885245901639344 14.3 14 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.18848216284649e-30 4.6145063235816e-28 0.926146942754957 0.885245901639344 14.3 14 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 5.90779549246943e-15 1.23629308614471e-13 0.925949806326103 0.885057471264368 14.3 14 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 5.90779549246943e-15 1.23629308614471e-13 0.925949806326103 0.885057471264368 14.3 14 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.00216515766594e-09 1.31294056191642e-08 0.925487293935331 0.884615384615385 14.3 14 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.00216515766594e-09 1.31294056191642e-08 0.925487293935331 0.884615384615385 14.3 14 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.74927145732237e-05 0.000101880554264837 0.925487293935331 0.884615384615385 14.3 14 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 2.74927145732237e-05 0.000101880554264837 0.925487293935331 0.884615384615385 14.3 14 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 2.74927145732237e-05 0.000101880554264837 0.925487293935331 0.884615384615385 14.3 14 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.58076800556389e-12 5.5240956541673e-11 0.92490412613827 0.884057971014493 14.3 14 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.58076800556389e-12 5.5240956541673e-11 0.92490412613827 0.884057971014493 14.3 14 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.28586819614547e-10 9.53015855789067e-10 0.924146008002091 0.883333333333333 14.3 14 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.28586819614547e-10 9.53015855789067e-10 0.924146008002091 0.883333333333333 14.3 14 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.28586819614547e-10 9.53015855789067e-10 0.924146008002091 0.883333333333333 14.3 14 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.28586819614547e-10 9.53015855789067e-10 0.924146008002091 0.883333333333333 14.3 14 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.28586819614547e-10 9.53015855789067e-10 0.924146008002091 0.883333333333333 14.3 14 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.28586819614547e-10 9.53015855789067e-10 0.924146008002091 0.883333333333333 14.3 14 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.28586819614547e-10 9.53015855789067e-10 0.924146008002091 0.883333333333333 14.3 14 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.28586819614547e-10 9.53015855789067e-10 0.924146008002091 0.883333333333333 14.3 14 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00086532327546273 0.00242392720666036 0.923120318759026 0.882352941176471 14.3 14 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00086532327546273 0.00242392720666036 0.923120318759026 0.882352941176471 14.3 14 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00086532327546273 0.00242392720666036 0.923120318759026 0.882352941176471 14.3 14 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00086532327546273 0.00242392720666036 0.923120318759026 0.882352941176471 14.3 14 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00086532327546273 0.00242392720666036 0.923120318759026 0.882352941176471 14.3 14 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.63890750012897e-09 2.30815016821576e-08 0.923120318759025 0.882352941176471 14.3 14 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 5.52970034319232e-18 1.78835536099152e-16 0.921426520009009 0.880733944954128 14.3 14 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.50766004294457e-11 1.42079486166233e-10 0.921283263398311 0.880597014925373 14.3 14 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 5.00601706856578e-05 0.000180343349077699 0.920658664575668 0.88 14.3 14 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 5.00601706856578e-05 0.000180343349077699 0.920658664575668 0.88 14.3 14 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 3.03289869420491e-06 1.30387155343009e-05 0.919390539693332 0.878787878787879 14.3 14 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.88635300077613e-07 9.8325286450712e-07 0.918617292813859 0.878048780487805 14.3 14 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.88635300077613e-07 9.8325286450712e-07 0.918617292813859 0.878048780487805 14.3 14 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.88635300077613e-07 9.8325286450712e-07 0.918617292813859 0.878048780487805 14.3 14 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.88635300077613e-07 9.8325286450712e-07 0.918617292813859 0.878048780487805 14.3 14 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 3.1955795733963e-12 4.02416790525924e-11 0.917219092977004 0.876712328767123 14.3 14 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.75190191171616e-13 5.5614129378876e-12 0.915427649436034 0.875 14.3 14 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.75543476181908e-12 5.60957785347161e-11 0.915427649436034 0.875 14.3 14 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 9.07180092763545e-05 0.00031409179367458 0.915427649436033 0.875 14.3 14 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 9.07180092763545e-05 0.00031409179367458 0.915427649436033 0.875 14.3 14 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00157519956710484 0.00413234696456957 0.915427649436033 0.875 14.3 14 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00157519956710484 0.00413234696456957 0.915427649436033 0.875 14.3 14 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00157519956710484 0.00413234696456957 0.915427649436033 0.875 14.3 14 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00157519956710484 0.00413234696456957 0.915427649436033 0.875 14.3 14 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0304734148577014 0.0558810171939551 0.915427649436033 0.875 14.3 14 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 6.74426794253231e-13 9.69403361840755e-12 0.913772264898175 0.873417721518987 14.3 14 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.21017146110708e-12 1.64007046586226e-11 0.912074434602935 0.871794871794872 14.3 14 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.08192322243775e-31 1.53957674552892e-29 0.91169121005058 0.871428571428571 14.3 14 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 9.87292101758481e-06 3.94639511461326e-05 0.911209088839554 0.870967741935484 14.3 14 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.41882244833509e-13 2.26852173480993e-12 0.910812047842238 0.870588235294118 14.3 14 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.41882244833509e-13 2.26852173480993e-12 0.910812047842238 0.870588235294118 14.3 14 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.41882244833509e-13 2.26852173480993e-12 0.910812047842238 0.870588235294118 14.3 14 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 6.94041422795466e-08 3.82798815751143e-07 0.909741763414692 0.869565217391304 14.3 14 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000163549287565897 0.000550190629329245 0.909741763414692 0.869565217391304 14.3 14 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.32345271525896e-11 2.78192541989029e-10 0.909741763414692 0.869565217391304 14.3 14 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.9606723922669e-15 4.35943252218093e-14 0.908822832340535 0.868686868686869 14.3 14 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.09872480133092e-06 4.93213057505962e-06 0.90854473477862 0.868421052631579 14.3 14 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00284657917804744 0.00692424302625899 0.906709290869976 0.866666666666667 14.3 14 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00284657917804744 0.00692424302625899 0.906709290869976 0.866666666666667 14.3 14 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00284657917804744 0.00692424302625899 0.906709290869976 0.866666666666667 14.3 14 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00284657917804744 0.00692424302625899 0.906709290869976 0.866666666666667 14.3 14 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00284657917804744 0.00692424302625899 0.906709290869976 0.866666666666667 14.3 14 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.96300497886351e-06 8.5423733483877e-06 0.904824240369207 0.864864864864865 14.3 14 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.43683051240539e-12 1.89315723995636e-11 0.90412607351707 0.864197530864197 14.3 14 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.43683051240539e-12 1.89315723995636e-11 0.90412607351707 0.864197530864197 14.3 14 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000293199212229507 0.000910966111359362 0.903538978664137 0.863636363636364 14.3 14 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000293199212229507 0.000910966111359362 0.903538978664137 0.863636363636364 14.3 14 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000293199212229507 0.000910966111359362 0.903538978664137 0.863636363636364 14.3 14 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000293199212229507 0.000910966111359362 0.903538978664137 0.863636363636364 14.3 14 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 4.46196848022368e-19 1.58734528683957e-17 0.901344147137018 0.861538461538462 14.3 14 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 3.49370615943158e-06 1.47087096593821e-05 0.900897051825938 0.861111111111111 14.3 14 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.52204758347641e-12 5.5240956541673e-11 0.900529188595303 0.860759493670886 14.3 14 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.52204758347641e-12 5.5240956541673e-11 0.900529188595303 0.860759493670886 14.3 14 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 6.19116063618731e-14 1.10125269816182e-12 0.899959593915609 0.860215053763441 14.3 14 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 4.4691954771726e-08 2.53373114104248e-07 0.89973460401713 0.86 14.3 14 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 5.91951249958021e-10 4.12915014063855e-09 0.899080727124676 0.859375 14.3 14 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.91951249958021e-10 4.12915014063855e-09 0.899080727124676 0.859375 14.3 14 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 6.86782630656977e-11 5.34039171270425e-10 0.898850488782262 0.859154929577465 14.3 14 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.04565170187034e-09 7.15366524885331e-09 0.896745452508768 0.857142857142857 14.3 14 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00510184867345755 0.011523699464016 0.896745452508768 0.857142857142857 14.3 14 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00510184867345755 0.011523699464016 0.896745452508768 0.857142857142857 14.3 14 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00510184867345755 0.011523699464016 0.896745452508768 0.857142857142857 14.3 14 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00510184867345755 0.011523699464016 0.896745452508768 0.857142857142857 14.3 14 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00510184867345755 0.011523699464016 0.896745452508768 0.857142857142857 14.3 14 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00510184867345755 0.011523699464016 0.896745452508768 0.857142857142857 14.3 14 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0554010264245514 0.0965014064708456 0.896745452508768 0.857142857142857 14.3 14 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 6.19283609984391e-06 2.53959820463339e-05 0.896745452508767 0.857142857142857 14.3 14 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000522413640357387 0.00153911927583553 0.896745452508767 0.857142857142857 14.3 14 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.3306075068246e-30 4.10830298814094e-28 0.89402804204662 0.854545454545454 14.3 14 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 5.10721124005356e-12 5.60957785347161e-11 0.893100145791252 0.853658536585366 14.3 14 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 3.75517567842982e-10 2.67180749520282e-09 0.892349641467058 0.852941176470588 14.3 14 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.4485140614588e-07 1.25332212570355e-06 0.890385555682464 0.851063829787234 14.3 14 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.4485140614588e-07 1.25332212570355e-06 0.890385555682464 0.851063829787234 14.3 14 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000924593678490441 0.00254767567088384 0.889272573737861 0.85 14.3 14 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000924593678490441 0.00254767567088384 0.889272573737861 0.85 14.3 14 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000924593678490441 0.00254767567088384 0.889272573737861 0.85 14.3 14 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000924593678490441 0.00254767567088384 0.889272573737861 0.85 14.3 14 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 4.9168742415022e-08 2.77647303399112e-07 0.888285589749251 0.849056603773585 14.3 14 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 4.28763417083878e-07 2.12588969515804e-06 0.886998219329324 0.847826086956522 14.3 14 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 4.28763417083878e-07 2.12588969515804e-06 0.886998219329324 0.847826086956522 14.3 14 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.89844306255867e-29 2.29138026556721e-27 0.886692252368535 0.847533632286996 14.3 14 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 5.60781405358518e-12 5.60957785347161e-11 0.886195506008664 0.847058823529412 14.3 14 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 5.60781405358518e-12 5.60957785347161e-11 0.886195506008664 0.847058823529412 14.3 14 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.60781405358518e-12 5.60957785347161e-11 0.886195506008664 0.847058823529412 14.3 14 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 5.60781405358518e-12 5.60957785347161e-11 0.886195506008664 0.847058823529412 14.3 14 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000174181179304045 0.000580467958195915 0.885248715938142 0.846153846153846 14.3 14 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000174181179304045 0.000580467958195915 0.885248715938142 0.846153846153846 14.3 14 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000174181179304045 0.000580467958195915 0.885248715938142 0.846153846153846 14.3 14 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0090583321832884 0.0192101441085237 0.885248715938142 0.846153846153846 14.3 14 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0090583321832884 0.0192101441085237 0.885248715938142 0.846153846153846 14.3 14 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0090583321832884 0.0192101441085237 0.885248715938142 0.846153846153846 14.3 14 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 7.48117792319778e-07 3.59652573807785e-06 0.883460334693823 0.844444444444444 14.3 14 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.49563414219685e-09 2.23062214544669e-08 0.882733804813318 0.84375 14.3 14 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 3.54642352849613e-15 7.76393950930768e-14 0.881013076148965 0.842105263157895 14.3 14 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00162435732100288 0.00421031050598743 0.881013076148965 0.842105263157895 14.3 14 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00162435732100288 0.00421031050598743 0.881013076148965 0.842105263157895 14.3 14 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 9.44521639053521e-23 5.16943958605062e-21 0.880701983961059 0.84180790960452 14.3 14 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.30043238734046e-06 5.74694188566918e-06 0.879761637120344 0.840909090909091 14.3 14 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.30043238734046e-06 5.74694188566918e-06 0.879761637120344 0.840909090909091 14.3 14 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000304171661877511 0.000938907320719519 0.878810543458592 0.84 14.3 14 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000304171661877511 0.000938907320719519 0.878810543458592 0.84 14.3 14 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 5.08822657268593e-11 4.11394682552959e-10 0.878293899988011 0.839506172839506 14.3 14 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.20482032502183e-08 2.92745427767038e-07 0.878063255581502 0.839285714285714 14.3 14 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 1.14023289256999e-05 4.45755880804149e-05 0.876548482857669 0.837837837837838 14.3 14 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.59006333542212e-16 4.04046451126014e-15 0.875890907101587 0.837209302325581 14.3 14 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.79179842368888e-11 1.66648964503874e-10 0.875890907101587 0.837209302325581 14.3 14 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.53651374798644e-13 2.42939895931634e-12 0.875189071438845 0.836538461538462 14.3 14 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 7.43226759555548e-10 5.10923516351471e-09 0.874224447993707 0.835616438356164 14.3 14 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 1.96884858019055e-05 7.49110034655389e-05 0.871835856605746 0.833333333333333 14.3 14 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 1.96884858019055e-05 7.49110034655389e-05 0.871835856605746 0.833333333333333 14.3 14 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0028305488739908 0.00692424302625899 0.871835856605746 0.833333333333333 14.3 14 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0028305488739908 0.00692424302625899 0.871835856605746 0.833333333333333 14.3 14 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0028305488739908 0.00692424302625899 0.871835856605746 0.833333333333333 14.3 14 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0028305488739908 0.00692424302625899 0.871835856605746 0.833333333333333 14.3 14 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0028305488739908 0.00692424302625899 0.871835856605746 0.833333333333333 14.3 14 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.000527705679013611 0.0015482993427554 0.871835856605746 0.833333333333333 14.3 14 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000527705679013611 0.0015482993427554 0.871835856605746 0.833333333333333 14.3 14 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0159101055845921 0.0321592048961286 0.871835856605746 0.833333333333333 14.3 14 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0159101055845921 0.0321592048961286 0.871835856605746 0.833333333333333 14.3 14 3 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 48%5605140 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 KLOTHO-MEDIATED LIGAND BINDING%REACTOME%REACT_222862.1 KLOTHO-MEDIATED LIGAND BINDING 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0991254382320048 0.157418515654277 0.871835856605746 0.833333333333333 14.3 14 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.26505107469029e-06 9.82673072952528e-06 0.864254675243957 0.826086956521739 14.3 14 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 6.37775172719083e-09 3.94588726425763e-08 0.864254675243957 0.826086956521739 14.3 14 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 6.37775172719083e-09 3.94588726425763e-08 0.864254675243957 0.826086956521739 14.3 14 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.82222138388883e-21 1.29549065460445e-19 0.863260421950608 0.825136612021858 14.3 14 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.13918900203103e-05 4.45755880804149e-05 0.863117498039689 0.825 14.3 14 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 1.13918900203103e-05 4.45755880804149e-05 0.863117498039689 0.825 14.3 14 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.13918900203103e-05 4.45755880804149e-05 0.863117498039689 0.825 14.3 14 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.70218920672106e-13 6.82777065424904e-12 0.862148791532349 0.824074074074074 14.3 14 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.25182079152149e-30 1.3074170225071e-28 0.861578964175091 0.823529411764706 14.3 14 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 5.78149860735435e-05 0.000207231045800132 0.861578964175091 0.823529411764706 14.3 14 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 5.78149860735435e-05 0.000207231045800132 0.861578964175091 0.823529411764706 14.3 14 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00488795559476797 0.0111467320694789 0.861578964175091 0.823529411764706 14.3 14 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00488795559476797 0.0111467320694789 0.861578964175091 0.823529411764706 14.3 14 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00488795559476797 0.0111467320694789 0.861578964175091 0.823529411764706 14.3 14 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00488795559476797 0.0111467320694789 0.861578964175091 0.823529411764706 14.3 14 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00488795559476797 0.0111467320694789 0.861578964175091 0.823529411764706 14.3 14 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00488795559476797 0.0111467320694789 0.861578964175091 0.823529411764706 14.3 14 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.1802465974796e-14 2.26958230839659e-13 0.860586361681801 0.82258064516129 14.3 14 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.1802465974796e-14 2.26958230839659e-13 0.860586361681801 0.82258064516129 14.3 14 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.1802465974796e-14 2.26958230839659e-13 0.860586361681801 0.82258064516129 14.3 14 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 5.33956802976262e-08 2.99141941194969e-07 0.860586361681801 0.82258064516129 14.3 14 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000297069963904643 0.000920981609229426 0.859381058654236 0.821428571428571 14.3 14 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 1.93764082071467e-05 7.41199701042196e-05 0.85842299727335 0.82051282051282 14.3 14 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 5.02232422547049e-16 1.25381883734114e-14 0.858037015709828 0.820143884892086 14.3 14 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.30959031814241e-06 5.76949542636731e-06 0.857886482900054 0.82 14.3 14 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.68943344952513e-13 6.82777065424904e-12 0.857697977849977 0.81981981981982 14.3 14 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.42469352088736e-28 1.06702046327511e-26 0.85708171134011 0.819230769230769 14.3 14 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00155387856693285 0.00413234696456957 0.855984295576551 0.818181818181818 14.3 14 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0275957492973767 0.0521811612891726 0.855984295576551 0.818181818181818 14.3 14 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0275957492973767 0.0521811612891726 0.855984295576551 0.818181818181818 14.3 14 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0275957492973767 0.0521811612891726 0.855984295576551 0.818181818181818 14.3 14 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0275957492973767 0.0521811612891726 0.855984295576551 0.818181818181818 14.3 14 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0275957492973767 0.0521811612891726 0.855984295576551 0.818181818181818 14.3 14 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0275957492973767 0.0521811612891726 0.855984295576551 0.818181818181818 14.3 14 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0275957492973767 0.0521811612891726 0.855984295576551 0.818181818181818 14.3 14 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 4.09318051110071e-15 8.82514525347925e-14 0.855984295576551 0.818181818181818 14.3 14 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 7.90578295171421e-13 1.11385437032568e-11 0.855984295576551 0.818181818181818 14.3 14 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 9.82618188688439e-05 0.000336931489759915 0.855984295576551 0.818181818181818 14.3 14 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 9.82618188688439e-05 0.000336931489759915 0.855984295576551 0.818181818181818 14.3 14 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 9.82618188688439e-05 0.000336931489759915 0.855984295576551 0.818181818181818 14.3 14 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 7.44833576852123e-18 2.35532928857905e-16 0.855386123462241 0.817610062893082 14.3 14 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.33019943117847e-12 1.7857299911009e-11 0.854239169591685 0.81651376146789 14.3 14 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.25253792231898e-17 3.79576951805146e-16 0.85417842153525 0.816455696202532 14.3 14 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 6.03602078767645e-17 1.56168319652065e-15 0.853481417519309 0.815789473684211 14.3 14 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.27915745923488e-05 0.000120887074209618 0.853481417519309 0.815789473684211 14.3 14 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.1033444585864e-17 5.86874345993812e-16 0.852955334870335 0.815286624203822 14.3 14 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000504359612673197 0.00148901188554763 0.852461726458952 0.814814814814815 14.3 14 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000504359612673197 0.00148901188554763 0.852461726458952 0.814814814814815 14.3 14 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000504359612673197 0.00148901188554763 0.852461726458952 0.814814814814815 14.3 14 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.18036124404873e-22 6.22094092696795e-21 0.851908179883329 0.814285714285714 14.3 14 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000166016922268884 0.000557174717897695 0.850039960190603 0.8125 14.3 14 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00835589082546545 0.0181533322818891 0.850039960190603 0.8125 14.3 14 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00835589082546545 0.0181533322818891 0.850039960190603 0.8125 14.3 14 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00835589082546545 0.0181533322818891 0.850039960190603 0.8125 14.3 14 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00835589082546545 0.0181533322818891 0.850039960190603 0.8125 14.3 14 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00835589082546545 0.0181533322818891 0.850039960190603 0.8125 14.3 14 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00835589082546545 0.0181533322818891 0.850039960190603 0.8125 14.3 14 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00263385884055591 0.00651822805236705 0.846926260702725 0.80952380952381 14.3 14 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00263385884055591 0.00651822805236705 0.846926260702725 0.80952380952381 14.3 14 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00263385884055591 0.00651822805236705 0.846926260702725 0.80952380952381 14.3 14 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.72241996676743e-08 1.02125150529585e-07 0.845561351338176 0.808219178082192 14.3 14 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000850131688686069 0.00240504451888723 0.845010137940954 0.807692307692308 14.3 14 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000850131688686069 0.00240504451888723 0.845010137940954 0.807692307692308 14.3 14 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000850131688686069 0.00240504451888723 0.845010137940954 0.807692307692308 14.3 14 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 2.03654950524533e-09 1.329362360534e-08 0.84452533579641 0.807228915662651 14.3 14 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 6.30074725231542e-15 1.28085190572069e-13 0.844435301112423 0.807142857142857 14.3 14 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.30074725231542e-15 1.28085190572069e-13 0.844435301112423 0.807142857142857 14.3 14 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000278726190186171 0.000873628565275157 0.843712119295883 0.806451612903226 14.3 14 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.000278726190186171 0.000873628565275157 0.843712119295883 0.806451612903226 14.3 14 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 8.36267631404274e-08 4.59462872389298e-07 0.843208410567946 0.805970149253731 14.3 14 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.86552288800357e-08 1.66434247739962e-07 0.842774661385555 0.805555555555556 14.3 14 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.21823341839148e-86 5.84727307718554e-83 0.841459675176496 0.804298642533937 14.3 14 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 5.73230419897514e-12 5.60957785347161e-11 0.84069886172697 0.803571428571429 14.3 14 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.63048395034169e-08 9.78978338116553e-08 0.839715588204482 0.802631578947368 14.3 14 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.92890836909844e-09 1.28263392954537e-08 0.839395452639021 0.802325581395349 14.3 14 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.1363236105726e-12 1.55479663254309e-11 0.838691683544701 0.801652892561983 14.3 14 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.1363236105726e-12 1.55479663254309e-11 0.838691683544701 0.801652892561983 14.3 14 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.78577117756196e-10 2.68017531625407e-09 0.836962422341516 0.8 14.3 14 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.72401821874631e-05 6.61260896300809e-05 0.836962422341516 0.8 14.3 14 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.001421841747558 0.00381751095617932 0.836962422341516 0.8 14.3 14 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.001421841747558 0.00381751095617932 0.836962422341516 0.8 14.3 14 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00442341189105263 0.0103698766408038 0.836962422341516 0.8 14.3 14 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00442341189105263 0.0103698766408038 0.836962422341516 0.8 14.3 14 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00442341189105263 0.0103698766408038 0.836962422341516 0.8 14.3 14 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00442341189105263 0.0103698766408038 0.836962422341516 0.8 14.3 14 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00442341189105263 0.0103698766408038 0.836962422341516 0.8 14.3 14 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.014122926655098 0.0287921556306655 0.836962422341516 0.8 14.3 14 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0471625561345403 0.0838903967243135 0.836962422341516 0.8 14.3 14 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0471625561345403 0.0838903967243135 0.836962422341516 0.8 14.3 14 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0471625561345403 0.0838903967243135 0.836962422341516 0.8 14.3 14 3 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0471625561345403 0.0838903967243135 0.836962422341516 0.8 14.3 14 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0471625561345403 0.0838903967243135 0.836962422341516 0.8 14.3 14 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0471625561345403 0.0838903967243135 0.836962422341516 0.8 14.3 14 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0471625561345403 0.0838903967243135 0.836962422341516 0.8 14.3 14 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0471625561345403 0.0838903967243135 0.836962422341516 0.8 14.3 14 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.13411155333426e-15 2.68973456732442e-14 0.836962422341516 0.8 14.3 14 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 4.459339163855e-14 8.0324552280578e-13 0.83545709424378 0.798561151079137 14.3 14 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 1.10834310323829e-06 4.95966111920783e-06 0.833415971399391 0.796610169491525 14.3 14 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 9.97653703777919e-13 1.39182472595684e-11 0.832019730870996 0.795275590551181 14.3 14 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000254271031079288 0.000809457890885517 0.830808286883123 0.794117647058823 14.3 14 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000254271031079288 0.000809457890885517 0.830808286883123 0.794117647058823 14.3 14 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 4.36394251348914e-18 1.44416051085931e-16 0.828244063775459 0.791666666666667 14.3 14 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.57756308150865e-05 6.06722233780218e-05 0.828244063775459 0.791666666666667 14.3 14 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00235809292078021 0.00598140147285248 0.828244063775459 0.791666666666667 14.3 14 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.25369759204792e-17 3.79576951805146e-16 0.828010952583853 0.79144385026738 14.3 14 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 4.67386098817297e-05 0.000169234203210436 0.827230301151499 0.790697674418605 14.3 14 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.5405800137973e-09 1.03407799982715e-08 0.825949758889654 0.789473684210526 14.3 14 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.5405800137973e-09 1.03407799982715e-08 0.825949758889654 0.789473684210526 14.3 14 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000139234382103358 0.000471739346983519 0.825949758889654 0.789473684210526 14.3 14 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 7.06194800168582e-12 6.83615782748226e-11 0.825054420397633 0.788617886178862 14.3 14 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 8.74198305602306e-06 3.51407962958215e-05 0.82489084894236 0.788461538461538 14.3 14 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000417678734897607 0.00125391738345843 0.82428117351816 0.787878787878788 14.3 14 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0235654383860015 0.0459364641414795 0.822016664799704 0.785714285714286 14.3 14 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0235654383860015 0.0459364641414795 0.822016664799704 0.785714285714286 14.3 14 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0235654383860015 0.0459364641414795 0.822016664799704 0.785714285714286 14.3 14 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0235654383860015 0.0459364641414795 0.822016664799704 0.785714285714286 14.3 14 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0235654383860015 0.0459364641414795 0.822016664799704 0.785714285714286 14.3 14 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 9.20040529935148e-07 4.15624658443719e-06 0.820866991142641 0.784615384615385 14.3 14 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.17232796534778e-08 7.15975405446306e-08 0.820318283260861 0.784090909090909 14.3 14 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00387531053211715 0.0091604101116324 0.818767587073223 0.782608695652174 14.3 14 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.89282893012063e-08 1.11763301558575e-07 0.817721906885389 0.781609195402299 14.3 14 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000681259289890767 0.00197843259084604 0.817346115567887 0.78125 14.3 14 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.70939256072173e-11 2.47145231660706e-10 0.816548704723431 0.780487804878049 14.3 14 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000123942711547856 0.000422950787847959 0.816548704723431 0.780487804878049 14.3 14 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 7.59240909867186e-44 1.35049976842626e-41 0.815019587298855 0.779026217228464 14.3 14 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 4.57599594161886e-07 2.24539387066332e-06 0.813713466165363 0.777777777777778 14.3 14 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0120888791174881 0.0254474482014579 0.813713466165363 0.777777777777778 14.3 14 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0120888791174881 0.0254474482014579 0.813713466165363 0.777777777777778 14.3 14 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0120888791174881 0.0254474482014579 0.813713466165363 0.777777777777778 14.3 14 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0791967674343503 0.129388059769323 0.813713466165363 0.777777777777778 14.3 14 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0791967674343503 0.129388059769323 0.813713466165363 0.777777777777778 14.3 14 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0791967674343503 0.129388059769323 0.813713466165363 0.777777777777778 14.3 14 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0791967674343503 0.129388059769323 0.813713466165363 0.777777777777778 14.3 14 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00206033395473112 0.00525422082004012 0.813713466165363 0.777777777777778 14.3 14 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00206033395473112 0.00525422082004012 0.813713466165363 0.777777777777778 14.3 14 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.00206033395473112 0.00525422082004012 0.813713466165363 0.777777777777778 14.3 14 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00206033395473112 0.00525422082004012 0.813713466165363 0.777777777777778 14.3 14 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.53865725263897e-07 1.29480619014525e-06 0.812183929574827 0.776315789473684 14.3 14 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 3.70844838435378e-05 0.000135658664548469 0.811341123698409 0.775510204081633 14.3 14 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 3.70844838435378e-05 0.000135658664548469 0.811341123698409 0.775510204081633 14.3 14 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000200029429312331 0.000641085310611366 0.810807346643344 0.775 14.3 14 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000200029429312331 0.000641085310611366 0.810807346643344 0.775 14.3 14 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 2.03371032132688e-05 7.71725276599506e-05 0.809326870660429 0.773584905660377 14.3 14 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.34253221034827e-08 2.47176933413024e-07 0.808429612488965 0.772727272727273 14.3 14 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.24983281377299e-07 1.16418621599962e-06 0.807827654475198 0.772151898734177 14.3 14 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.42283967863958e-17 9.36673242827715e-16 0.807070907257891 0.771428571428571 14.3 14 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 5.94135648733517e-05 0.000211893490763858 0.806448167360315 0.770833333333333 14.3 14 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 5.94135648733517e-05 0.000211893490763858 0.806448167360315 0.770833333333333 14.3 14 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.28790211920253e-25 8.33038507102366e-24 0.805512147268867 0.769938650306748 14.3 14 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 4.06476471353409e-20 1.56328653712406e-18 0.805410267531023 0.76984126984127 14.3 14 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 4.06476471353409e-20 1.56328653712406e-18 0.805410267531023 0.76984126984127 14.3 14 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 4.06476471353409e-20 1.56328653712406e-18 0.805410267531023 0.76984126984127 14.3 14 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00332754194379779 0.00790499530221078 0.804771559943766 0.769230769230769 14.3 14 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0387493502556044 0.070153085768098 0.804771559943766 0.769230769230769 14.3 14 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0387493502556044 0.070153085768098 0.804771559943766 0.769230769230769 14.3 14 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0387493502556044 0.070153085768098 0.804771559943766 0.769230769230769 14.3 14 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0387493502556044 0.070153085768098 0.804771559943766 0.769230769230769 14.3 14 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0387493502556044 0.070153085768098 0.804771559943766 0.769230769230769 14.3 14 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 3.3816671408496e-06 1.43645144520268e-05 0.804771559943766 0.769230769230769 14.3 14 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.83253556374096e-13 2.83445446435151e-12 0.803790131212127 0.768292682926829 14.3 14 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.32786962607973e-17 3.85624179165603e-16 0.802245371190579 0.766816143497758 14.3 14 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000948753772307147 0.00260130369555505 0.800037609591156 0.764705882352941 14.3 14 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0196266803252322 0.038736152708468 0.800037609591156 0.764705882352941 14.3 14 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0196266803252322 0.038736152708468 0.800037609591156 0.764705882352941 14.3 14 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0196266803252322 0.038736152708468 0.800037609591156 0.764705882352941 14.3 14 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.73472703837179e-07 9.17664154499277e-07 0.800037609591155 0.764705882352941 14.3 14 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.73472703837179e-07 9.17664154499277e-07 0.800037609591155 0.764705882352941 14.3 14 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.73472703837179e-07 9.17664154499277e-07 0.800037609591155 0.764705882352941 14.3 14 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.73472703837179e-07 9.17664154499277e-07 0.800037609591155 0.764705882352941 14.3 14 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.73472703837179e-07 9.17664154499277e-07 0.800037609591155 0.764705882352941 14.3 14 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 4.07858585491598e-28 2.90191383577272e-26 0.800037609591155 0.764705882352941 14.3 14 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 9.59872260355469e-08 5.2534547172532e-07 0.799346133696954 0.764044943820225 14.3 14 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 2.82239829876633e-05 0.000104318773484272 0.798918675871447 0.763636363636364 14.3 14 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000149940813591467 0.000505606108390183 0.796024042987855 0.760869565217391 14.3 14 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000149940813591467 0.000505606108390183 0.796024042987855 0.760869565217391 14.3 14 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.56243062354329e-08 1.49440113823856e-07 0.795114301224441 0.76 14.3 14 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.41978643071655e-08 8.59725996131764e-08 0.794711915444469 0.759615384615385 14.3 14 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.54976929346152e-11 3.69961240262614e-10 0.793927120483531 0.75886524822695 14.3 14 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0015049485242444 0.00402931934085536 0.792578051459769 0.757575757575758 14.3 14 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 4.02177629352025e-06 1.68819695152782e-05 0.792125149716078 0.757142857142857 14.3 14 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000435898254382204 0.00130585940207553 0.791031557700823 0.75609756097561 14.3 14 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.12319034193867e-13 1.97320969947991e-12 0.790338156966513 0.755434782608696 14.3 14 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.04790724430663e-06 4.71889876154537e-06 0.787881292636304 0.753086419753086 14.3 14 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.3097911370485e-19 1.2394296810579e-17 0.785596497504672 0.750902527075812 14.3 14 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.19418261071312e-11 2.01440119680308e-10 0.784652270945172 0.75 14.3 14 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.73535347192603e-07 1.39014571091098e-06 0.784652270945172 0.75 14.3 14 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000109059420266967 0.000373056622692052 0.784652270945172 0.75 14.3 14 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00444807084445074 0.0104105342296931 0.784652270945172 0.75 14.3 14 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0161448331176242 0.0325412146265994 0.784652270945172 0.75 14.3 14 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0161448331176242 0.0325412146265994 0.784652270945172 0.75 14.3 14 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 SPERM MOTILITY AND TAXES%REACTOME%REACT_196630.2 SPERM MOTILITY AND TAXES 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%REACT_208465.1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 EARLY STAGE PANCREATIC PRECURSOR CELLS%REACTOME%REACT_13403.1 EARLY STAGE PANCREATIC PRECURSOR CELLS 0.130183861125102 0.194592052921239 0.784652270945172 0.75 14.3 14 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00842696336612798 0.0182520074124811 0.784652270945172 0.75 14.3 14 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00842696336612798 0.0182520074124811 0.784652270945172 0.75 14.3 14 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0626526804357307 0.104519067127837 0.784652270945172 0.75 14.3 14 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0626526804357307 0.104519067127837 0.784652270945172 0.75 14.3 14 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0626526804357307 0.104519067127837 0.784652270945172 0.75 14.3 14 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0626526804357307 0.104519067127837 0.784652270945172 0.75 14.3 14 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0626526804357307 0.104519067127837 0.784652270945172 0.75 14.3 14 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0626526804357307 0.104519067127837 0.784652270945172 0.75 14.3 14 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0626526804357307 0.104519067127837 0.784652270945172 0.75 14.3 14 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.81105284301683e-11 3.17141999743447e-10 0.778113502020629 0.74375 14.3 14 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00197510185729242 0.00507323094391175 0.777179392174265 0.742857142857143 14.3 14 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.3343738345035e-05 8.74161570131179e-05 0.776726490430574 0.742424242424242 14.3 14 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00369192162300514 0.00874143838525176 0.776215149752213 0.741935483870968 14.3 14 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00694813619827399 0.0152580213119504 0.774965205871774 0.740740740740741 14.3 14 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00694813619827399 0.0152580213119504 0.774965205871774 0.740740740740741 14.3 14 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000261043345428861 0.000825477067878375 0.774190240665903 0.74 14.3 14 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0131921552806862 0.0276193828034855 0.773280498902488 0.739130434782609 14.3 14 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0131921552806862 0.0276193828034855 0.773280498902488 0.739130434782609 14.3 14 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000885681946891017 0.00247122629495278 0.772197472993661 0.738095238095238 14.3 14 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000885681946891017 0.00247122629495278 0.772197472993661 0.738095238095238 14.3 14 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 6.52971306684088e-05 0.000232294542352864 0.771789118962464 0.737704918032787 14.3 14 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00163991524929745 0.00424290799954595 0.770886441630344 0.736842105263158 14.3 14 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0253471924929072 0.0492074419064215 0.770886441630344 0.736842105263158 14.3 14 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00304993394629232 0.00740623891736173 0.769266932299188 0.735294117647059 14.3 14 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.17693670380144e-45 2.79130154918243e-43 0.76891234062745 0.734955185659411 14.3 14 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000400158005607054 0.00120385801686858 0.768638959293229 0.73469387755102 14.3 14 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.81878481612787e-09 1.21508487950702e-08 0.768191034491777 0.734265734265734 14.3 14 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00570335523116133 0.0128415735663648 0.767215553813057 0.733333333333333 14.3 14 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0495323456459861 0.0879956652362524 0.767215553813057 0.733333333333333 14.3 14 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0107388284195366 0.022706319228827 0.764532981946577 0.730769230769231 14.3 14 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0025111626147023 0.00626106612832433 0.763445452811518 0.72972972972973 14.3 14 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000609433367890569 0.0017844108693586 0.762856374530028 0.729166666666667 14.3 14 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.55436187252104e-07 1.78093554387234e-06 0.762652674563531 0.728971962616822 14.3 14 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 9.68167203238923e-06 3.88085050763095e-05 0.762049119107245 0.728395061728395 14.3 14 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00111955061260411 0.00305781290160393 0.760874929401378 0.727272727272727 14.3 14 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0204011546706898 0.0400978495806513 0.760874929401378 0.727272727272727 14.3 14 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0993407077003097 0.157418515654277 0.760874929401378 0.727272727272727 14.3 14 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0993407077003097 0.157418515654277 0.760874929401378 0.727272727272727 14.3 14 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0993407077003097 0.157418515654277 0.760874929401378 0.727272727272727 14.3 14 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0993407077003097 0.157418515654277 0.760874929401378 0.727272727272727 14.3 14 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0993407077003097 0.157418515654277 0.760874929401378 0.727272727272727 14.3 14 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0993407077003097 0.157418515654277 0.760874929401378 0.727272727272727 14.3 14 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.00986753922989e-08 1.72009699129483e-07 0.758696852313398 0.725190839694656 14.3 14 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.00986753922989e-08 1.72009699129483e-07 0.758696852313398 0.725190839694656 14.3 14 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00872276513518882 0.0188353486910071 0.757595296084993 0.724137931034483 14.3 14 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0392249634653669 0.0707441356289191 0.75559107572498 0.722222222222222 14.3 14 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0392249634653669 0.0707441356289191 0.75559107572498 0.722222222222222 14.3 14 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.44067903677967e-07 7.76547829294495e-07 0.754638249652187 0.721311475409836 14.3 14 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00169106317706683 0.00435150615002912 0.754239392226366 0.720930232558139 14.3 14 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0164088706722128 0.0328052176610468 0.753266180107365 0.72 14.3 14 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0164088706722128 0.0328052176610468 0.753266180107365 0.72 14.3 14 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0164088706722128 0.0328052176610468 0.753266180107365 0.72 14.3 14 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0164088706722128 0.0328052176610468 0.753266180107365 0.72 14.3 14 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0164088706722128 0.0328052176610468 0.753266180107365 0.72 14.3 14 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 8.25037722009309e-07 3.79944556122734e-06 0.751363992783861 0.718181818181818 14.3 14 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00311006833719882 0.00752657694529578 0.751120122614181 0.717948717948718 14.3 14 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00311006833719882 0.00752657694529578 0.751120122614181 0.717948717948718 14.3 14 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0131982995828321 0.0276193828034855 0.74728787709064 0.714285714285714 14.3 14 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0131982995828321 0.0276193828034855 0.74728787709064 0.714285714285714 14.3 14 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0767091299296115 0.125902066770285 0.74728787709064 0.714285714285714 14.3 14 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0767091299296115 0.125902066770285 0.74728787709064 0.714285714285714 14.3 14 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0767091299296115 0.125902066770285 0.74728787709064 0.714285714285714 14.3 14 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0767091299296115 0.125902066770285 0.74728787709064 0.714285714285714 14.3 14 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0767091299296115 0.125902066770285 0.74728787709064 0.714285714285714 14.3 14 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0767091299296115 0.125902066770285 0.74728787709064 0.714285714285714 14.3 14 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0767091299296115 0.125902066770285 0.74728787709064 0.714285714285714 14.3 14 3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.208436467750638 0.292798710374292 0.74728787709064 0.714285714285714 14.3 14 3 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.208436467750638 0.292798710374292 0.74728787709064 0.714285714285714 14.3 14 3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.208436467750638 0.292798710374292 0.74728787709064 0.714285714285714 14.3 14 3 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.208436467750638 0.292798710374292 0.74728787709064 0.714285714285714 14.3 14 3 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.208436467750638 0.292798710374292 0.74728787709064 0.714285714285714 14.3 14 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.208436467750638 0.292798710374292 0.74728787709064 0.714285714285714 14.3 14 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00113262177359936 0.0030875877084902 0.74728787709064 0.714285714285714 14.3 14 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0025345989111074 0.00630547945892627 0.74728787709064 0.714285714285714 14.3 14 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0057370141687921 0.0128766106659167 0.74728787709064 0.714285714285714 14.3 14 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0057370141687921 0.0128766106659167 0.74728787709064 0.714285714285714 14.3 14 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.47620435734855e-75 1.17454626683566e-72 0.746323012175093 0.713363460296966 14.3 14 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000925779775829412 0.00254767567088384 0.744413692947983 0.711538461538462 14.3 14 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00206434481007955 0.00525503160061394 0.743966597636904 0.711111111111111 14.3 14 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.000756287896631316 0.0021697533808596 0.741853056166344 0.709090909090909 14.3 14 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00168066518607074 0.00433258434742511 0.741060478114884 0.708333333333333 14.3 14 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00168066518607074 0.00433258434742511 0.741060478114884 0.708333333333333 14.3 14 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.024764764216042 0.0481424309828247 0.741060478114884 0.708333333333333 14.3 14 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00061756779145406 0.00179713490232951 0.739557312844874 0.706896551724138 14.3 14 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00061756779145406 0.00179713490232951 0.739557312844874 0.706896551724138 14.3 14 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00061756779145406 0.00179713490232951 0.739557312844874 0.706896551724138 14.3 14 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00855069798981492 0.0184918590266058 0.73849625500722 0.705882352941177 14.3 14 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0597376833090282 0.100718866526952 0.73849625500722 0.705882352941177 14.3 14 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0597376833090282 0.100718866526952 0.73849625500722 0.705882352941177 14.3 14 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0197417224450352 0.0388554232908507 0.736216945578186 0.703703703703704 14.3 14 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0197417224450352 0.0388554232908507 0.736216945578186 0.703703703703704 14.3 14 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.015768054911253 0.0319628805394771 0.732342119548827 0.7 14.3 14 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.015768054911253 0.0319628805394771 0.732342119548827 0.7 14.3 14 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.15394326046724 0.227006486678635 0.732342119548827 0.7 14.3 14 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.15394326046724 0.227006486678635 0.732342119548827 0.7 14.3 14 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.15394326046724 0.227006486678635 0.732342119548827 0.7 14.3 14 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.15394326046724 0.227006486678635 0.732342119548827 0.7 14.3 14 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.15394326046724 0.227006486678635 0.732342119548827 0.7 14.3 14 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.15394326046724 0.227006486678635 0.732342119548827 0.7 14.3 14 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.15394326046724 0.227006486678635 0.732342119548827 0.7 14.3 14 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.15394326046724 0.227006486678635 0.732342119548827 0.7 14.3 14 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000273937949519905 0.000862419695059348 0.732342119548827 0.7 14.3 14 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.4127552715353e-27 2.31254797685464e-25 0.728925282288101 0.696734059097978 14.3 14 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.003617946886332 0.00858056403208407 0.727793410731753 0.695652173913043 14.3 14 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.97377380056118e-06 1.28232730854502e-05 0.72559242259446 0.693548387096774 14.3 14 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.37636356248847e-23 8.1606889559212e-22 0.725562870506218 0.693520140105079 14.3 14 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 4.19796788784898e-40 6.63745367156567e-38 0.72469719251793 0.692692692692693 14.3 14 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00811380258583749 0.0177903560549257 0.724294403949389 0.692307692307692 14.3 14 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0291664657407342 0.0545386080802428 0.724294403949389 0.692307692307692 14.3 14 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.116435173341015 0.17630622431139 0.724294403949389 0.692307692307692 14.3 14 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.116435173341015 0.17630622431139 0.724294403949389 0.692307692307692 14.3 14 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.116435173341015 0.17630622431139 0.724294403949389 0.692307692307692 14.3 14 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.116435173341015 0.17630622431139 0.724294403949389 0.692307692307692 14.3 14 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.116435173341015 0.17630622431139 0.724294403949389 0.692307692307692 14.3 14 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.82257981583989e-07 1.42937049037016e-06 0.722217574117276 0.690322580645161 14.3 14 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00524506059092055 0.0118284013009191 0.72071764146075 0.688888888888889 14.3 14 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0893706309503645 0.144680782528292 0.719264581699741 0.6875 14.3 14 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 8.6470758403297e-06 3.48577589824055e-05 0.717643399321755 0.685950413223141 14.3 14 3 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.0541265484430569 0.0957986050179974 0.713320246313792 0.681818181818182 14.3 14 3 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.0541265484430569 0.0957986050179974 0.713320246313792 0.681818181818182 14.3 14 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0335556151541308 0.0613748590801132 0.709923483236108 0.678571428571429 14.3 14 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0265785650509102 0.0515276540428409 0.708718180208542 0.67741935483871 14.3 14 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.60385962624405e-17 4.56458449629058e-16 0.70810082987735 0.676829268292683 14.3 14 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.31136511574656e-17 3.85624179165603e-16 0.708036392637394 0.676767676767677 14.3 14 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0211170725679254 0.0414477162264246 0.707725577715253 0.676470588235294 14.3 14 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 7.78400945451303e-05 0.000272823779649558 0.707432523645806 0.676190476190476 14.3 14 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.00994871658774e-09 1.92935001067764e-08 0.701571442256859 0.670588235294118 14.3 14 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0378956852436127 0.0690468119099371 0.697468685284597 0.666666666666667 14.3 14 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.100763122996351 0.159140870170707 0.697468685284597 0.666666666666667 14.3 14 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.100763122996351 0.159140870170707 0.697468685284597 0.666666666666667 14.3 14 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.100763122996351 0.159140870170707 0.697468685284597 0.666666666666667 14.3 14 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.131062698496863 0.195494989476977 0.697468685284597 0.666666666666667 14.3 14 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.131062698496863 0.195494989476977 0.697468685284597 0.666666666666667 14.3 14 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.232158048506604 0.319713367953894 0.697468685284597 0.666666666666667 14.3 14 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.232158048506604 0.319713367953894 0.697468685284597 0.666666666666667 14.3 14 3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.232158048506604 0.319713367953894 0.697468685284597 0.666666666666667 14.3 14 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.232158048506604 0.319713367953894 0.697468685284597 0.666666666666667 14.3 14 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.232158048506604 0.319713367953894 0.697468685284597 0.666666666666667 14.3 14 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.232158048506604 0.319713367953894 0.697468685284597 0.666666666666667 14.3 14 3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.232158048506604 0.319713367953894 0.697468685284597 0.666666666666667 14.3 14 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00626502118621422 0.0140395671621777 0.697468685284597 0.666666666666667 14.3 14 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00971781635898659 0.020578054581604 0.697468685284597 0.666666666666667 14.3 14 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0300167868340616 0.0558810171939551 0.697468685284597 0.666666666666667 14.3 14 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0611070742542956 0.102784121352083 0.697468685284597 0.666666666666667 14.3 14 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0611070742542956 0.102784121352083 0.697468685284597 0.666666666666667 14.3 14 3 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.172716762229468 0.247901388054986 0.697468685284597 0.666666666666667 14.3 14 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.172716762229468 0.247901388054986 0.697468685284597 0.666666666666667 14.3 14 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.172716762229468 0.247901388054986 0.697468685284597 0.666666666666667 14.3 14 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 4.14630913337193e-07 2.07024487606605e-06 0.695698460195042 0.66497461928934 14.3 14 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 6.82798941421947e-05 0.000242299973477165 0.694610207066217 0.663934426229508 14.3 14 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00454387559907849 0.0106172988136103 0.691843937822624 0.661290322580645 14.3 14 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00214939520058464 0.00546176673291418 0.688291465741379 0.657894736842105 14.3 14 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0533378137384376 0.0946380410845345 0.685443363124518 0.655172413793103 14.3 14 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0677463411467967 0.112227058733285 0.684055825952201 0.653846153846154 14.3 14 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0677463411467967 0.112227058733285 0.684055825952201 0.653846153846154 14.3 14 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.00091939048593578 0.00254767567088384 0.682785134015448 0.652631578947368 14.3 14 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0864659500948009 0.140137866725401 0.682306322561019 0.652173913043478 14.3 14 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0864659500948009 0.140137866725401 0.682306322561019 0.652173913043478 14.3 14 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.34655997521389e-05 0.000123053096763033 0.679698782474798 0.64968152866242 14.3 14 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.00101194022849462 0.00276921335605354 0.67949268824118 0.649484536082474 14.3 14 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.187942051481542 0.26717436489334 0.672559089381576 0.642857142857143 14.3 14 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.187942051481542 0.26717436489334 0.672559089381576 0.642857142857143 14.3 14 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00668946327927048 0.0147354585857614 0.672559089381576 0.642857142857143 14.3 14 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.51371904482719e-05 5.83745853872384e-05 0.670223814765667 0.640625 14.3 14 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0941489164900581 0.152243077460628 0.669569937873213 0.64 14.3 14 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 4.62313056917573e-05 0.000167824357141252 0.669083331813712 0.63953488372093 14.3 14 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.25599198449023e-06 5.58523935603e-06 0.668057355182234 0.63855421686747 14.3 14 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0634127523102649 0.105293286508176 0.665765563226206 0.636363636363636 14.3 14 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0634127523102649 0.105293286508176 0.665765563226206 0.636363636363636 14.3 14 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0634127523102649 0.105293286508176 0.665765563226206 0.636363636363636 14.3 14 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0634127523102649 0.105293286508176 0.665765563226206 0.636363636363636 14.3 14 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.249497727809368 0.329652058191951 0.665765563226206 0.636363636363636 14.3 14 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0800105811385898 0.130567725871804 0.662595251020367 0.633333333333333 14.3 14 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.154711104294615 0.227666909422169 0.660759807111723 0.631578947368421 14.3 14 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.154711104294615 0.227666909422169 0.660759807111723 0.631578947368421 14.3 14 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000927404074151672 0.00254767567088384 0.659025529402769 0.62992125984252 14.3 14 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.000206210217711451 0.000659409302928977 0.658720424991008 0.62962962962963 14.3 14 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.000268936636945556 0.00084855173918742 0.656313700749171 0.627329192546584 14.3 14 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0856580892991764 0.13914550350768 0.65387689245431 0.625 14.3 14 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.200549477741026 0.283398119985581 0.65387689245431 0.625 14.3 14 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.200549477741026 0.283398119985581 0.65387689245431 0.625 14.3 14 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.200549477741026 0.283398119985581 0.65387689245431 0.625 14.3 14 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.200549477741026 0.283398119985581 0.65387689245431 0.625 14.3 14 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.200549477741026 0.283398119985581 0.65387689245431 0.625 14.3 14 3 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.338857478793198 0.430146469511794 0.65387689245431 0.625 14.3 14 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.338857478793198 0.430146469511794 0.65387689245431 0.625 14.3 14 3 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.338857478793198 0.430146469511794 0.65387689245431 0.625 14.3 14 3 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.338857478793198 0.430146469511794 0.65387689245431 0.625 14.3 14 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.338857478793198 0.430146469511794 0.65387689245431 0.625 14.3 14 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.338857478793198 0.430146469511794 0.65387689245431 0.625 14.3 14 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0240680046180253 0.0468519433261969 0.651733033790525 0.622950819672131 14.3 14 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.05811727516223e-08 6.4900900110166e-08 0.649771835730381 0.621076233183857 14.3 14 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0426717356773028 0.0767659669643513 0.648645877314675 0.62 14.3 14 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.164391077484446 0.241163405423058 0.647649493478554 0.619047619047619 14.3 14 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.262767304450991 0.345261195045023 0.643817247955013 0.615384615384615 14.3 14 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.262767304450991 0.345261195045023 0.643817247955013 0.615384615384615 14.3 14 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.262767304450991 0.345261195045023 0.643817247955013 0.615384615384615 14.3 14 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.262767304450991 0.345261195045023 0.643817247955013 0.615384615384615 14.3 14 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00123062043759261 0.00334832291146134 0.641221210664871 0.612903225806452 14.3 14 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00136502515917592 0.003678846214976 0.63824964596798 0.610062893081761 14.3 14 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00136502515917592 0.003678846214976 0.63824964596798 0.610062893081761 14.3 14 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0812551532601812 0.132446830571865 0.63792867556518 0.609756097560976 14.3 14 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.17296270528838 0.247901388054986 0.636819234390284 0.608695652173913 14.3 14 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.17296270528838 0.247901388054986 0.636819234390284 0.608695652173913 14.3 14 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0015063934570169 0.00402931934085536 0.635423924937194 0.607361963190184 14.3 14 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0143867192295888 0.0292461449481499 0.634399708423756 0.606382978723404 14.3 14 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0852608199632582 0.138658453494533 0.632587877351146 0.604651162790698 14.3 14 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.149804939890212 0.222750709993491 0.627721816756137 0.6 14.3 14 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.180603483170688 0.25751378412013 0.627721816756137 0.6 14.3 14 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.220231130453135 0.308453640388594 0.627721816756137 0.6 14.3 14 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.220231130453135 0.308453640388594 0.627721816756137 0.6 14.3 14 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.349480230565649 0.441661072908454 0.627721816756137 0.6 14.3 14 3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.349480230565649 0.441661072908454 0.627721816756137 0.6 14.3 14 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.349480230565649 0.441661072908454 0.627721816756137 0.6 14.3 14 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.349480230565649 0.441661072908454 0.627721816756137 0.6 14.3 14 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.349480230565649 0.441661072908454 0.627721816756137 0.6 14.3 14 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0594946705262441 0.100547406364424 0.621183047831594 0.59375 14.3 14 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.155700727837656 0.228886503835728 0.621183047831594 0.59375 14.3 14 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0389194895745707 0.0703715802599924 0.61997216469742 0.592592592592593 14.3 14 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.228060124498239 0.318791313517676 0.61821088013862 0.590909090909091 14.3 14 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.228060124498239 0.318791313517676 0.61821088013862 0.590909090909091 14.3 14 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.28176630076228 0.3695423465297 0.61541354583935 0.588235294117647 14.3 14 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.28176630076228 0.3695423465297 0.61541354583935 0.588235294117647 14.3 14 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0746779963262801 0.123566033456159 0.614436698941193 0.587301587301587 14.3 14 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.117669809906877 0.17756536532077 0.614075690304917 0.58695652173913 14.3 14 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0136601240683951 0.0278886033706259 0.611513037450228 0.584507042253521 14.3 14 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.35699107962123 0.449158537843511 0.610285099624022 0.583333333333333 14.3 14 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.35699107962123 0.449158537843511 0.610285099624022 0.583333333333333 14.3 14 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.35699107962123 0.449158537843511 0.610285099624022 0.583333333333333 14.3 14 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.35699107962123 0.449158537843511 0.610285099624022 0.583333333333333 14.3 14 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.35699107962123 0.449158537843511 0.610285099624022 0.583333333333333 14.3 14 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0471166009977301 0.0838903967243135 0.607472725893036 0.580645161290323 14.3 14 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.199224671915288 0.28293084644257 0.607472725893036 0.580645161290323 14.3 14 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.109006491116049 0.171969220463567 0.605696489852413 0.578947368421053 14.3 14 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.362534308410256 0.454125282454044 0.597830301672512 0.571428571428571 14.3 14 3 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.362534308410256 0.454125282454044 0.597830301672512 0.571428571428571 14.3 14 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.362534308410256 0.454125282454044 0.597830301672512 0.571428571428571 14.3 14 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.362534308410256 0.454125282454044 0.597830301672512 0.571428571428571 14.3 14 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.362534308410256 0.454125282454044 0.597830301672512 0.571428571428571 14.3 14 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0301550930739398 0.0558810171939551 0.597830301672512 0.571428571428571 14.3 14 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0353606425645757 0.0645105056017836 0.595648439257649 0.569343065693431 14.3 14 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0353606425645757 0.0645105056017836 0.595648439257649 0.569343065693431 14.3 14 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0827165132536491 0.134674597665838 0.594433538594827 0.568181818181818 14.3 14 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.213212716999812 0.299212718235436 0.593790907742292 0.567567567567568 14.3 14 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.250942024617778 0.331252783887846 0.592848382491907 0.566666666666667 14.3 14 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0421950296510347 0.0760044648018005 0.592335537870375 0.566176470588235 14.3 14 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.161202138671607 0.236729250082247 0.592190393166167 0.566037735849057 14.3 14 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.366747427952534 0.458998759873751 0.588489203208879 0.5625 14.3 14 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.0143288707267126 0.0291702189472275 0.588208569349456 0.562231759656652 14.3 14 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.303976140202935 0.392520914254788 0.585873695639061 0.56 14.3 14 3 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.472231766651441 0.571903299519359 0.581223904403831 0.555555555555556 14.3 14 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.472231766651441 0.571903299519359 0.581223904403831 0.555555555555556 14.3 14 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.472231766651441 0.571903299519359 0.581223904403831 0.555555555555556 14.3 14 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.472231766651441 0.571903299519359 0.581223904403831 0.555555555555556 14.3 14 3 INTERACTION WITH THE ZONA PELLUCIDA%REACTOME%REACT_199072.2 INTERACTION WITH THE ZONA PELLUCIDA 0.472231766651441 0.571903299519359 0.581223904403831 0.555555555555556 14.3 14 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.140617679436741 0.209308533303851 0.578488733088989 0.552941176470588 14.3 14 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.140617679436741 0.209308533303851 0.578488733088989 0.552941176470588 14.3 14 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.310913920193195 0.401115601482245 0.577215463683804 0.551724137931034 14.3 14 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.372589182589819 0.465900181744563 0.575411665359792 0.55 14.3 14 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0306468779226492 0.0561267790011968 0.574385976116727 0.549019607843137 14.3 14 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.23962067830958 0.32047013649862 0.570656197051034 0.545454545454545 14.3 14 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.469459233873187 0.571903299519359 0.570656197051034 0.545454545454545 14.3 14 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.469459233873187 0.571903299519359 0.570656197051034 0.545454545454545 14.3 14 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.469459233873187 0.571903299519359 0.570656197051034 0.545454545454545 14.3 14 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.469459233873187 0.571903299519359 0.570656197051034 0.545454545454545 14.3 14 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.170151450466755 0.247901388054986 0.569599426315754 0.544444444444444 14.3 14 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.322111944909515 0.41272421784742 0.563340091960636 0.538461538461538 14.3 14 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.466918817319844 0.571903299519359 0.563340091960636 0.538461538461538 14.3 14 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.466918817319844 0.571903299519359 0.563340091960636 0.538461538461538 14.3 14 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.323656645065733 0.413432141767089 0.561377234497359 0.536585365853659 14.3 14 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.251428470476382 0.331587315558751 0.561007420772393 0.536231884057971 14.3 14 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.233576084139932 0.319713367953894 0.554487604801255 0.53 14.3 14 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.462351196041569 0.571903299519359 0.553872191255415 0.529411764705882 14.3 14 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.330737073996548 0.422097628965998 0.551634323815999 0.527272727272727 14.3 14 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.460265177249295 0.571903299519359 0.550633172593103 0.526315789473684 14.3 14 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.184593157765109 0.262939002502253 0.548549695723832 0.524324324324324 14.3 14 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.44954556247521 0.560160538881107 0.539975756349365 0.516129032258065 14.3 14 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.446453573862596 0.557283715444276 0.53804727150526 0.514285714285714 14.3 14 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.420119356268529 0.524872558358311 0.529723052114884 0.506329113924051 14.3 14 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.447069260386492 0.557563152962295 0.523101513963448 0.5 14.3 14 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.554686121852081 0.648577117005351 0.523101513963448 0.5 14.3 14 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.571303326229431 0.666364453462689 0.523101513963448 0.5 14.3 14 3 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.571303326229431 0.666364453462689 0.523101513963448 0.5 14.3 14 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.571303326229431 0.666364453462689 0.523101513963448 0.5 14.3 14 3 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.594983302737233 0.689463550321729 0.523101513963448 0.5 14.3 14 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.594983302737233 0.689463550321729 0.523101513963448 0.5 14.3 14 3 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.594983302737233 0.689463550321729 0.523101513963448 0.5 14.3 14 3 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.594983302737233 0.689463550321729 0.523101513963448 0.5 14.3 14 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.594983302737233 0.689463550321729 0.523101513963448 0.5 14.3 14 3 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.594983302737233 0.689463550321729 0.523101513963448 0.5 14.3 14 3 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.594983302737233 0.689463550321729 0.523101513963448 0.5 14.3 14 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.585815161647433 0.682731347276247 0.507249952934252 0.484848484848485 14.3 14 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.601590499650472 0.696552710335737 0.503963653696492 0.481707317073171 14.3 14 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.655728711920489 0.751895211170714 0.490407669340732 0.46875 14.3 14 3 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.664702989369516 0.759523250736655 0.488228079699218 0.466666666666667 14.3 14 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.664702989369516 0.759523250736655 0.488228079699218 0.466666666666667 14.3 14 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.718882776651513 0.810594446256024 0.486114538228658 0.464646464646465 14.3 14 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.995549700617435 1 0.482274078727276 0.460975609756098 14.3 14 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.705773764437698 0.797709346143641 0.478264241338009 0.457142857142857 14.3 14 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.699586693457271 0.791344884570506 0.475546830875862 0.454545454545455 14.3 14 3 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.699586693457271 0.791344884570506 0.475546830875862 0.454545454545455 14.3 14 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.713990003814703 0.806355377324065 0.475546830875862 0.454545454545455 14.3 14 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.71471171751935 0.806530352125325 0.470791362567103 0.45 14.3 14 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.744291985401034 0.823582811217473 0.457713824718017 0.4375 14.3 14 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.76240829075488 0.841665630523036 0.448372726254384 0.428571428571429 14.3 14 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.793213937477481 0.874317144097951 0.440506538074482 0.421052631578947 14.3 14 3 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.783629054408791 0.864421817382721 0.435917928302873 0.416666666666667 14.3 14 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.818470148796221 0.892477411292738 0.435917928302873 0.416666666666667 14.3 14 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.887207459433658 0.953546990010646 0.434272954988523 0.415094339622642 14.3 14 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.80939779336151 0.88326154904404 0.430789482087545 0.411764705882353 14.3 14 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.827545158345123 0.901682052316317 0.418481211170758 0.4 14.3 14 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.876275134736006 0.946084610568541 0.418481211170758 0.4 14.3 14 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999893975196931 1 0.415245531702943 0.396907216494845 14.3 14 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.956961201987022 1 0.412587109604973 0.394366197183099 14.3 14 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.94772767519683 1 0.411620863446647 0.39344262295082 14.3 14 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999684100142277 1 0.407271893014399 0.389285714285714 14.3 14 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.940986078087359 0.998525868097175 0.405670561849204 0.387755102040816 14.3 14 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.905831095863292 0.967715953013111 0.404981817262024 0.387096774193548 14.3 14 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.905831095863292 0.967715953013111 0.404981817262024 0.387096774193548 14.3 14 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.848080861476088 0.921235928153033 0.402385779971883 0.384615384615385 14.3 14 3 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.848080861476088 0.921235928153033 0.402385779971883 0.384615384615385 14.3 14 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.921848924615405 0.98408928711757 0.400018804795578 0.382352941176471 14.3 14 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.958161943790542 1 0.392326135472586 0.375 14.3 14 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.923523109888835 0.985137470293712 0.387482602935887 0.37037037037037 14.3 14 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999695044369206 1 0.380437464700689 0.363636363636364 14.3 14 3 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.895676734098981 0.960473242368387 0.37364393854532 0.357142857142857 14.3 14 3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.895676734098981 0.960473242368387 0.37364393854532 0.357142857142857 14.3 14 3 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.895676734098981 0.960473242368387 0.37364393854532 0.357142857142857 14.3 14 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.944283296067626 1 0.37364393854532 0.357142857142857 14.3 14 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.953738761415054 1 0.371233332490189 0.354838709677419 14.3 14 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999986497057035 1 0.366412120379927 0.350230414746544 14.3 14 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999955023588759 1 0.365608585028216 0.349462365591398 14.3 14 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.997049891458524 1 0.357563060177547 0.341772151898734 14.3 14 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.951286203996418 1 0.348734342642298 0.333333333333333 14.3 14 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.960585362300352 1 0.330379903555862 0.315789473684211 14.3 14 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.973795731157161 1 0.313860908378069 0.3 14.3 14 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.997505097502668 1 0.311634944488862 0.297872340425532 14.3 14 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.996232559258538 1 0.278987474113839 0.266666666666667 14.3 14 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.268797755286003 0.256926952141058 14.3 14 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.997321795462497 1 0.261550756981724 0.25 14.3 14 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999966961512 1 0.251863691908327 0.240740740740741 14.3 14 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.999612868911957 1 0.247784927666896 0.236842105263158 14.3 14 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999942423398411 1 0.23975486056658 0.229166666666667 14.3 14 3 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.999326175278015 1 0.236239393402847 0.225806451612903 14.3 14 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.999326175278015 1 0.236239393402847 0.225806451612903 14.3 14 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999951576812 1 0.232489561761532 0.222222222222222 14.3 14 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.225132297148826 0.215189873417722 14.3 14 3 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999999808871165 1 0.155817472244431 0.148936170212766 14.3 14 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0168742423859177 0.0161290322580645 14.3 14 3 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00143337160821002 0.00784495307108792 2.70389780543727 1 14.2 14 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0020815092066109 0.0101786515498533 2.31762669037481 0.857142857142857 14.2 14 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 7.71586679954873e-05 0.000699342576799863 2.25324817119773 0.833333333333333 14.2 14 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00219625887197934 0.010594157202802 2.10303162645121 0.777777777777778 14.2 14 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00219625887197934 0.010594157202802 2.10303162645121 0.777777777777778 14.2 14 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00219625887197934 0.010594157202802 2.10303162645121 0.777777777777778 14.2 14 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000252804606059017 0.00181687350718172 2.0799213887979 0.769230769230769 14.2 14 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.06183464580481e-05 0.000148136343233357 2.02792335407796 0.75 14.2 14 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000728142826641435 0.00434822248595771 2.02792335407796 0.75 14.2 14 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 8.67383116038511e-05 0.000748052226741092 2.02792335407796 0.75 14.2 14 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 8.67383116038511e-05 0.000748052226741092 2.02792335407796 0.75 14.2 14 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 8.67383116038511e-05 0.000748052226741092 2.02792335407796 0.75 14.2 14 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00641220243803076 0.0254166130064562 2.02792335407796 0.75 14.2 14 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00641220243803076 0.0254166130064562 2.02792335407796 0.75 14.2 14 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00641220243803076 0.0254166130064562 2.02792335407796 0.75 14.2 14 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 2.106918045928e-08 5.99628875871108e-07 1.98816015105682 0.735294117647059 14.2 14 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00204928284437646 0.0100616094063285 1.96647113122711 0.727272727272727 14.2 14 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00204928284437646 0.0100616094063285 1.96647113122711 0.727272727272727 14.2 14 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 8.20691495595033e-05 0.000720891356933168 1.9528150817047 0.722222222222222 14.2 14 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 8.20691495595033e-05 0.000720891356933168 1.9528150817047 0.722222222222222 14.2 14 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 9.31359019323075e-10 6.02419947498516e-08 1.94932167368734 0.720930232558139 14.2 14 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0181274041519973 0.0607249490541385 1.93135557531234 0.714285714285714 14.2 14 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0181274041519973 0.0607249490541385 1.93135557531234 0.714285714285714 14.2 14 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0181274041519973 0.0607249490541385 1.93135557531234 0.714285714285714 14.2 14 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0181274041519973 0.0607249490541385 1.93135557531234 0.714285714285714 14.2 14 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0181274041519973 0.0607249490541385 1.93135557531234 0.714285714285714 14.2 14 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0181274041519973 0.0607249490541385 1.93135557531234 0.714285714285714 14.2 14 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0181274041519973 0.0607249490541385 1.93135557531234 0.714285714285714 14.2 14 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 4.21074375203255e-07 8.81160052815046e-06 1.91889521676194 0.709677419354839 14.2 14 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000222090785902254 0.00163748802248139 1.90863374501455 0.705882352941177 14.2 14 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00560966280475853 0.0230709542519404 1.89272846380609 0.7 14.2 14 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00560966280475853 0.0230709542519404 1.89272846380609 0.7 14.2 14 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00560966280475853 0.0230709542519404 1.89272846380609 0.7 14.2 14 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00560966280475853 0.0230709542519404 1.89272846380609 0.7 14.2 14 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.13861150099953e-09 1.08277279274144e-07 1.88097238639115 0.695652173913043 14.2 14 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.51533317149884e-05 0.000277129825799854 1.88097238639115 0.695652173913043 14.2 14 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00058843613610213 0.00353309966950772 1.85892974123813 0.6875 14.2 14 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000195392270036157 0.00145572356157828 1.85003534056235 0.684210526315789 14.2 14 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000195392270036157 0.00145572356157828 1.85003534056235 0.684210526315789 14.2 14 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 6.55521663979925e-05 0.00060985410851269 1.84356668552541 0.681818181818182 14.2 14 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.05089128458105e-07 2.67038981778363e-06 1.82513101867016 0.675 14.2 14 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.52329767181048e-09 9.03188577910963e-08 1.81993121519817 0.673076923076923 14.2 14 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.52329767181048e-09 9.03188577910963e-08 1.81993121519817 0.673076923076923 14.2 14 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.000167664693866297 0.00126907903921139 1.80259853695818 0.666666666666667 14.2 14 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0046915628798465 0.0202920789605519 1.80259853695818 0.666666666666667 14.2 14 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0046915628798465 0.0202920789605519 1.80259853695818 0.666666666666667 14.2 14 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0046915628798465 0.0202920789605519 1.80259853695818 0.666666666666667 14.2 14 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0046915628798465 0.0202920789605519 1.80259853695818 0.666666666666667 14.2 14 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0046915628798465 0.0202920789605519 1.80259853695818 0.666666666666667 14.2 14 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0148440895701336 0.0517724006330886 1.80259853695818 0.666666666666667 14.2 14 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0148440895701336 0.0517724006330886 1.80259853695818 0.666666666666667 14.2 14 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0148440895701336 0.0517724006330886 1.80259853695818 0.666666666666667 14.2 14 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0148440895701336 0.0517724006330886 1.80259853695818 0.666666666666667 14.2 14 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0148440895701336 0.0517724006330886 1.80259853695818 0.666666666666667 14.2 14 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0148440895701336 0.0517724006330886 1.80259853695818 0.666666666666667 14.2 14 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0148440895701336 0.0517724006330886 1.80259853695818 0.666666666666667 14.2 14 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0148440895701336 0.0517724006330886 1.80259853695818 0.666666666666667 14.2 14 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.63114075406135e-05 0.0002110102993663 1.77151925183821 0.655172413793103 14.2 14 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 4.78743453497412e-05 0.000460305361031633 1.76793318047822 0.653846153846154 14.2 14 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 4.78743453497412e-05 0.000460305361031633 1.76793318047822 0.653846153846154 14.2 14 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000141299981428625 0.00111705485318297 1.7634116122417 0.652173913043478 14.2 14 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00126006927813523 0.00697695946609508 1.74958093293 0.647058823529412 14.2 14 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.64827151326306e-07 3.7830489731828e-06 1.74251191905958 0.644444444444444 14.2 14 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 4.00685309537568e-05 0.000393224272739282 1.73822001778111 0.642857142857143 14.2 14 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00382807523863031 0.0170763356256142 1.73822001778111 0.642857142857143 14.2 14 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000117490664844185 0.000963002728257639 1.73049459547986 0.64 14.2 14 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.9729938879439e-07 8.43816463066294e-06 1.72066223982372 0.636363636363636 14.2 14 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0118403277354271 0.0433130754948915 1.72066223982372 0.636363636363636 14.2 14 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0118403277354271 0.0433130754948915 1.72066223982372 0.636363636363636 14.2 14 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0118403277354271 0.0433130754948915 1.72066223982372 0.636363636363636 14.2 14 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 1.14112772758414e-06 2.16509967513631e-05 1.714666901009 0.634146341463415 14.2 14 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 3.30679813854454e-07 7.12965719871043e-06 1.70463122516698 0.630434782608696 14.2 14 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 9.66944888318945e-05 0.000814179039099325 1.70245417379384 0.62962962962963 14.2 14 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 9.66944888318945e-05 0.000814179039099325 1.70245417379384 0.62962962962963 14.2 14 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 9.46149743570109e-07 1.84434395219214e-05 1.69779629643736 0.627906976744186 14.2 14 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000282664671111354 0.00197172464211498 1.6899361283983 0.625 14.2 14 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00307764113993408 0.01421910176015 1.6899361283983 0.625 14.2 14 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0376527403419416 0.105889030645421 1.6899361283983 0.625 14.2 14 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 7.80194838741828e-07 1.56368627539383e-05 1.68242530116097 0.622222222222222 14.2 14 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 7.76767105099661e-06 0.000112789754138451 1.68080133851506 0.621621621621622 14.2 14 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 7.76767105099661e-06 0.000112789754138451 1.68080133851506 0.621621621621622 14.2 14 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 7.89438238116272e-05 0.000708220035121446 1.67828139647831 0.620689655172414 14.2 14 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000830070311931721 0.00482118389338302 1.67384149860403 0.619047619047619 14.2 14 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000228876776035297 0.00167021360152937 1.66393711103832 0.615384615384615 14.2 14 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000228876776035297 0.00167021360152937 1.66393711103832 0.615384615384615 14.2 14 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00932181737087791 0.0356584573084927 1.66393711103832 0.615384615384615 14.2 14 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00932181737087791 0.0356584573084927 1.66393711103832 0.615384615384615 14.2 14 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.55958350751475e-08 4.62351527331977e-07 1.65722768720349 0.612903225806452 14.2 14 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.81085387692566e-05 0.000224073484075236 1.65238199221167 0.611111111111111 14.2 14 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.81085387692566e-05 0.000224073484075236 1.65238199221167 0.611111111111111 14.2 14 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00245111033742413 0.0115878073427061 1.65238199221167 0.611111111111111 14.2 14 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00245111033742413 0.0115878073427061 1.65238199221167 0.611111111111111 14.2 14 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.47944043301106e-06 2.73408277425291e-05 1.64585083809225 0.608695652173913 14.2 14 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.71556930783282e-09 1.20164889205593e-07 1.64585083809225 0.608695652173913 14.2 14 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.18001862479407e-05 0.000163025874085627 1.62233868326236 0.6 14.2 14 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000530425680512108 0.00329605128108616 1.62233868326236 0.6 14.2 14 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000530425680512108 0.00329605128108616 1.62233868326236 0.6 14.2 14 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000530425680512108 0.00329605128108616 1.62233868326236 0.6 14.2 14 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000530425680512108 0.00329605128108616 1.62233868326236 0.6 14.2 14 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0019399282748537 0.00989432951654772 1.62233868326236 0.6 14.2 14 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0019399282748537 0.00989432951654772 1.62233868326236 0.6 14.2 14 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0019399282748537 0.00989432951654772 1.62233868326236 0.6 14.2 14 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0019399282748537 0.00989432951654772 1.62233868326236 0.6 14.2 14 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0019399282748537 0.00989432951654772 1.62233868326236 0.6 14.2 14 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0019399282748537 0.00989432951654772 1.62233868326236 0.6 14.2 14 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00728735607776708 0.0282558792879089 1.62233868326236 0.6 14.2 14 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00728735607776708 0.0282558792879089 1.62233868326236 0.6 14.2 14 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00728735607776708 0.0282558792879089 1.62233868326236 0.6 14.2 14 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0286957297181962 0.0874390222462382 1.62233868326236 0.6 14.2 14 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0286957297181962 0.0874390222462382 1.62233868326236 0.6 14.2 14 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0286957297181962 0.0874390222462382 1.62233868326236 0.6 14.2 14 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0286957297181962 0.0874390222462382 1.62233868326236 0.6 14.2 14 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0286957297181962 0.0874390222462382 1.62233868326236 0.6 14.2 14 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0286957297181962 0.0874390222462382 1.62233868326236 0.6 14.2 14 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0286957297181962 0.0874390222462382 1.62233868326236 0.6 14.2 14 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 9.69015646234694e-12 1.06069943430151e-09 1.61141384364444 0.595959595959596 14.2 14 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000117752968880414 0.000963002728257639 1.60543932197838 0.59375 14.2 14 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000421141921058426 0.00276168181412968 1.6023098106295 0.592592592592593 14.2 14 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000421141921058426 0.00276168181412968 1.6023098106295 0.592592592592593 14.2 14 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.001528760649148 0.00817829475089325 1.59775779412203 0.590909090909091 14.2 14 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.001528760649148 0.00817829475089325 1.59775779412203 0.590909090909091 14.2 14 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00567417237107528 0.0231957675961889 1.59052812084546 0.588235294117647 14.2 14 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000333330637261531 0.00225392577829857 1.5850435411184 0.586206896551724 14.2 14 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000333330637261531 0.00225392577829857 1.5850435411184 0.586206896551724 14.2 14 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.11739906065045e-05 0.000257526398573127 1.58276944708523 0.585365853658537 14.2 14 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.11739906065045e-05 0.000257526398573127 1.58276944708523 0.585365853658537 14.2 14 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00120110078031699 0.00670261337408264 1.57727371983841 0.583333333333333 14.2 14 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.02184859853324 0.0692439993603574 1.57727371983841 0.583333333333333 14.2 14 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.02184859853324 0.0692439993603574 1.57727371983841 0.583333333333333 14.2 14 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.02184859853324 0.0692439993603574 1.57727371983841 0.583333333333333 14.2 14 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.02184859853324 0.0692439993603574 1.57727371983841 0.583333333333333 14.2 14 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 7.43534439651475e-05 0.000682718439633405 1.57727371983841 0.583333333333333 14.2 14 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00440791850495252 0.0194194056735215 1.56541451893737 0.578947368421053 14.2 14 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000941628732071395 0.0052961963863146 1.55994104159843 0.576923076923077 14.2 14 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 8.38310276627305e-06 0.00012049651753946 1.54508446024987 0.571428571428571 14.2 14 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000163207346882936 0.00124862394953988 1.54508446024987 0.571428571428571 14.2 14 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000163207346882936 0.00124862394953988 1.54508446024987 0.571428571428571 14.2 14 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000737054705369155 0.00434822248595771 1.54508446024987 0.571428571428571 14.2 14 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0166468068805414 0.0570804968458082 1.54508446024987 0.571428571428571 14.2 14 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0166468068805414 0.0570804968458082 1.54508446024987 0.571428571428571 14.2 14 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0166468068805414 0.0570804968458082 1.54508446024987 0.571428571428571 14.2 14 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0166468068805414 0.0570804968458082 1.54508446024987 0.571428571428571 14.2 14 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 6.62810267671595e-06 0.00010141709794588 1.53751051681727 0.568627450980392 14.2 14 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00265119919477594 0.0123693654234956 1.52829006394281 0.565217391304348 14.2 14 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00265119919477594 0.0123693654234956 1.52829006394281 0.565217391304348 14.2 14 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0126998467121238 0.0458677204856656 1.52094251555847 0.5625 14.2 14 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0126998467121238 0.0458677204856656 1.52094251555847 0.5625 14.2 14 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.09904634299561e-07 2.71449173882044e-06 1.51418277104487 0.56 14.2 14 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.5680395001211e-06 4.5672117683382e-05 1.51234961999034 0.559322033898305 14.2 14 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.5680395001211e-06 4.5672117683382e-05 1.51234961999034 0.559322033898305 14.2 14 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000351464296928634 0.00234804551422275 1.51100171480318 0.558823529411765 14.2 14 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000351464296928634 0.00234804551422275 1.51100171480318 0.558823529411765 14.2 14 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 8.74051907064663e-06 0.000124377586375302 1.50216544746515 0.555555555555556 14.2 14 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000274274725530172 0.00192262529275583 1.50216544746515 0.555555555555556 14.2 14 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0661635538067016 0.160659214424102 1.50216544746515 0.555555555555556 14.2 14 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0661635538067016 0.160659214424102 1.50216544746515 0.555555555555556 14.2 14 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0661635538067016 0.160659214424102 1.50216544746515 0.555555555555556 14.2 14 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.80234050539733e-05 0.000381037361914112 1.49577325407168 0.553191489361702 14.2 14 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000166888508655573 0.00126907903921139 1.4871437929905 0.55 14.2 14 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000956432723806693 0.00535828254321623 1.48278266749786 0.548387096774194 14.2 14 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000741499280563851 0.00434822248595771 1.47485334842033 0.545454545454545 14.2 14 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000741499280563851 0.00434822248595771 1.47485334842033 0.545454545454545 14.2 14 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 6.31994988692781e-09 1.95506275849962e-07 1.47485334842033 0.545454545454545 14.2 14 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.005688912783605 0.0231957675961889 1.47485334842033 0.545454545454545 14.2 14 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0489222120975191 0.128040730129466 1.47485334842033 0.545454545454545 14.2 14 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0489222120975191 0.128040730129466 1.47485334842033 0.545454545454545 14.2 14 2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0489222120975191 0.128040730129466 1.47485334842033 0.545454545454545 14.2 14 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0489222120975191 0.128040730129466 1.47485334842033 0.545454545454545 14.2 14 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0489222120975191 0.128040730129466 1.47485334842033 0.545454545454545 14.2 14 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0489222120975191 0.128040730129466 1.47485334842033 0.545454545454545 14.2 14 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 7.91335106003583e-05 0.000708220035121446 1.46950967686808 0.543478260869565 14.2 14 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.4288668310519e-07 3.38879583431141e-06 1.46596868969491 0.542168674698795 14.2 14 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.41819233972758e-09 1.14702923314412e-07 1.46566423098469 0.542056074766355 14.2 14 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00436495186640924 0.0192898338692557 1.46461131127852 0.541666666666667 14.2 14 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.90103659246856e-09 1.04045195041645e-07 1.46357771119999 0.541284403669725 14.2 14 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 4.17767177510623e-06 6.83313440916801e-05 1.45594497215853 0.538461538461538 14.2 14 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0033532555663685 0.0151481989553726 1.45594497215853 0.538461538461538 14.2 14 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0364631765559958 0.105889030645421 1.45594497215853 0.538461538461538 14.2 14 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0364631765559958 0.105889030645421 1.45594497215853 0.538461538461538 14.2 14 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0364631765559958 0.105889030645421 1.45594497215853 0.538461538461538 14.2 14 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0364631765559958 0.105889030645421 1.45594497215853 0.538461538461538 14.2 14 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 3.26691965516165e-06 5.50225183015562e-05 1.45284061187674 0.537313432835821 14.2 14 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 3.26691965516165e-06 5.50225183015562e-05 1.45284061187674 0.537313432835821 14.2 14 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000268640576930948 0.00189245317313237 1.45087199316146 0.536585365853659 14.2 14 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000268640576930948 0.00189245317313237 1.45087199316146 0.536585365853659 14.2 14 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000268640576930948 0.00189245317313237 1.45087199316146 0.536585365853659 14.2 14 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000268640576930948 0.00189245317313237 1.45087199316146 0.536585365853659 14.2 14 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0025789863309935 0.0121118730990223 1.44851668148425 0.535714285714286 14.2 14 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.99758400902919e-06 3.64431031390839e-05 1.44715657192418 0.535211267605634 14.2 14 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000208577519101373 0.00154586359208987 1.44627091918738 0.534883720930233 14.2 14 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.7795162009792e-05 0.000224073484075236 1.44518675807854 0.53448275862069 14.2 14 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.7795162009792e-05 0.000224073484075236 1.44518675807854 0.53448275862069 14.2 14 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00198557895636228 0.0100616094063285 1.44207882956655 0.533333333333333 14.2 14 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.027343322083712 0.0845859724459178 1.44207882956655 0.533333333333333 14.2 14 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.027343322083712 0.0845859724459178 1.44207882956655 0.533333333333333 14.2 14 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.027343322083712 0.0845859724459178 1.44207882956655 0.533333333333333 14.2 14 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000125849539630341 0.00101177341748008 1.43824351353047 0.531914893617021 14.2 14 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.10793542843006e-08 1.08251705826963e-06 1.43472128451774 0.530612244897959 14.2 14 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 4.56587415347459e-07 9.41628829042658e-06 1.43339160770169 0.530120481927711 14.2 14 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.21664237597069e-08 8.64804781933622e-07 1.43306583688176 0.53 14.2 14 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0206037303458034 0.0667280921276344 1.43147530876091 0.529411764705882 14.2 14 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0206037303458034 0.0667280921276344 1.43147530876091 0.529411764705882 14.2 14 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0206037303458034 0.0667280921276344 1.43147530876091 0.529411764705882 14.2 14 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0206037303458034 0.0667280921276344 1.43147530876091 0.529411764705882 14.2 14 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000911145854047715 0.0051450815488488 1.4270571750919 0.527777777777778 14.2 14 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000911145854047715 0.0051450815488488 1.4270571750919 0.527777777777778 14.2 14 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0118294243363626 0.0433130754948915 1.41632742189572 0.523809523809524 14.2 14 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0118294243363626 0.0433130754948915 1.41632742189572 0.523809523809524 14.2 14 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 8.19213207439854e-10 5.55114473422339e-08 1.41434654438257 0.523076923076923 14.2 14 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00032586775367995 0.00222937410330081 1.41340112556948 0.522727272727273 14.2 14 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.000252384263909362 0.00181687350718172 1.41072928979336 0.521739130434783 14.2 14 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 4.83514063023721e-06 7.81864217821313e-05 1.40750844666598 0.520547945205479 14.2 14 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000151625046730122 0.00117262196465741 1.40602685882738 0.52 14.2 14 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00524973683463252 0.0222926395861953 1.40202108430081 0.518518518518518 14.2 14 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00524973683463252 0.0222926395861953 1.40202108430081 0.518518518518518 14.2 14 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00524973683463252 0.0222926395861953 1.40202108430081 0.518518518518518 14.2 14 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.86113262603886e-08 7.98312103304568e-07 1.40111068099932 0.518181818181818 14.2 14 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 4.70230369321911e-10 3.71743230858378e-08 1.40058015821211 0.517985611510791 14.2 14 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00402010111478976 0.0178211959076194 1.39856783039859 0.517241379310345 14.2 14 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00236816850876108 0.0113084019730437 1.39291705128587 0.515151515151515 14.2 14 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.000497191812972295 0.00315849977615882 1.38199221166794 0.511111111111111 14.2 14 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000384420497939643 0.00255621667555193 1.38071377298925 0.51063829787234 14.2 14 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000230252564077833 0.00167168060552427 1.37845770473273 0.509803921568627 14.2 14 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.32098211232523e-13 1.7088704962171e-11 1.37770031038947 0.509523809523809 14.2 14 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 5.50312399429857e-09 1.74021009864153e-07 1.37243297700225 0.507575757575758 14.2 14 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.18803035252377e-15 2.11320898955166e-13 1.35712878357197 0.501915708812261 14.2 14 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 5.77318876489304e-05 0.000551358900163946 1.35194890271864 0.5 14.2 14 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000573267286335569 0.00345660740870981 1.35194890271864 0.5 14.2 14 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00124604474124763 0.00692625651091942 1.35194890271864 0.5 14.2 14 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00355604838036867 0.0159629553478379 1.35194890271864 0.5 14.2 14 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.00605462327321723 0.0244765026073526 1.35194890271864 0.5 14.2 14 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0103822214565515 0.0388786871912443 1.35194890271864 0.5 14.2 14 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0103822214565515 0.0388786871912443 1.35194890271864 0.5 14.2 14 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0136406124400641 0.0490166452076042 1.35194890271864 0.5 14.2 14 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0759958256617982 0.17527076161546 1.35194890271864 0.5 14.2 14 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0759958256617982 0.17527076161546 1.35194890271864 0.5 14.2 14 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0759958256617982 0.17527076161546 1.35194890271864 0.5 14.2 14 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0759958256617982 0.17527076161546 1.35194890271864 0.5 14.2 14 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0759958256617982 0.17527076161546 1.35194890271864 0.5 14.2 14 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0759958256617982 0.17527076161546 1.35194890271864 0.5 14.2 14 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.707030624468e-05 0.000277129825799854 1.35194890271864 0.5 14.2 14 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 7.43649740992113e-05 0.000682718439633405 1.35194890271864 0.5 14.2 14 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000741999362035226 0.00434822248595771 1.35194890271864 0.5 14.2 14 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00463648248430486 0.0202920789605519 1.35194890271864 0.5 14.2 14 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00792048733827154 0.0304617661685416 1.35194890271864 0.5 14.2 14 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00792048733827154 0.0304617661685416 1.35194890271864 0.5 14.2 14 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0179699358891203 0.0607249490541385 1.35194890271864 0.5 14.2 14 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0179699358891203 0.0607249490541385 1.35194890271864 0.5 14.2 14 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0237484963916201 0.0744363664433379 1.35194890271864 0.5 14.2 14 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0237484963916201 0.0744363664433379 1.35194890271864 0.5 14.2 14 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0315044607784676 0.0943807319742304 1.35194890271864 0.5 14.2 14 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0315044607784676 0.0943807319742304 1.35194890271864 0.5 14.2 14 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0315044607784676 0.0943807319742304 1.35194890271864 0.5 14.2 14 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0315044607784676 0.0943807319742304 1.35194890271864 0.5 14.2 14 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0315044607784676 0.0943807319742304 1.35194890271864 0.5 14.2 14 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0315044607784676 0.0943807319742304 1.35194890271864 0.5 14.2 14 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0419867974553002 0.114677951590964 1.35194890271864 0.5 14.2 14 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0419867974553002 0.114677951590964 1.35194890271864 0.5 14.2 14 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0419867974553002 0.114677951590964 1.35194890271864 0.5 14.2 14 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0419867974553002 0.114677951590964 1.35194890271864 0.5 14.2 14 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0419867974553002 0.114677951590964 1.35194890271864 0.5 14.2 14 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0562795462314501 0.143266179404926 1.35194890271864 0.5 14.2 14 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0562795462314501 0.143266179404926 1.35194890271864 0.5 14.2 14 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.103631377895207 0.221422598716035 1.35194890271864 0.5 14.2 14 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.103631377895207 0.221422598716035 1.35194890271864 0.5 14.2 14 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.103631377895207 0.221422598716035 1.35194890271864 0.5 14.2 14 2 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.103631377895207 0.221422598716035 1.35194890271864 0.5 14.2 14 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.103631377895207 0.221422598716035 1.35194890271864 0.5 14.2 14 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.103631377895207 0.221422598716035 1.35194890271864 0.5 14.2 14 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.103631377895207 0.221422598716035 1.35194890271864 0.5 14.2 14 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 8.1604756960708e-24 3.87078563850291e-21 1.3456017247716 0.497652582159624 14.2 14 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.1085692092253e-10 5.55114473422339e-08 1.33546172097817 0.49390243902439 14.2 14 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.959106764494e-05 0.000391236730963539 1.33342905473619 0.493150684931507 14.2 14 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 6.55711023207601e-05 0.00060985410851269 1.3323554403604 0.492753623188406 14.2 14 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.000501351203024679 0.00317076783068497 1.32644043285602 0.490566037735849 14.2 14 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.000838078247253945 0.00484790790992831 1.3243581087856 0.489795918367347 14.2 14 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 3.45794859808188e-05 0.000348983039366703 1.31728354623867 0.487179487179487 14.2 14 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 9.46017896883231e-05 0.000806097884589723 1.31332179121239 0.485714285714286 14.2 14 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00677136622599315 0.0264715773065611 1.31098075415141 0.484848484848485 14.2 14 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00677136622599315 0.0264715773065611 1.31098075415141 0.484848484848485 14.2 14 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00677136622599315 0.0264715773065611 1.31098075415141 0.484848484848485 14.2 14 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0151481000340477 0.0527035363042785 1.30187672113647 0.481481481481481 14.2 14 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.25956462823191e-15 1.1753360465974e-12 1.30119314186572 0.48122866894198 14.2 14 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.79224880632217e-06 8.95909788195266e-05 1.29787094660989 0.48 14.2 14 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.019892496066468 0.0652235527709307 1.29787094660989 0.48 14.2 14 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.019892496066468 0.0652235527709307 1.29787094660989 0.48 14.2 14 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00155517798161479 0.00828845793197696 1.29561769843869 0.479166666666667 14.2 14 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0261898268136803 0.0815495044986149 1.29316851564391 0.478260869565217 14.2 14 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000286869447537887 0.00199129377486055 1.2895512610547 0.476923076923077 14.2 14 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00337837467331557 0.0152133770890129 1.28757038354156 0.476190476190476 14.2 14 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0345840164418542 0.102527198743247 1.28757038354156 0.476190476190476 14.2 14 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0345840164418542 0.102527198743247 1.28757038354156 0.476190476190476 14.2 14 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0345840164418542 0.102527198743247 1.28757038354156 0.476190476190476 14.2 14 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.2066346443782e-09 1.08277279274144e-07 1.285459612421 0.475409836065574 14.2 14 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.2066346443782e-09 1.08277279274144e-07 1.285459612421 0.475409836065574 14.2 14 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 6.14778450872645e-08 1.59059951925777e-06 1.28079369731239 0.473684210526316 14.2 14 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.59974809019954e-06 4.5672117683382e-05 1.28079369731239 0.473684210526316 14.2 14 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0458306941490764 0.123051090139879 1.28079369731239 0.473684210526316 14.2 14 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0458306941490764 0.123051090139879 1.28079369731239 0.473684210526316 14.2 14 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0458306941490764 0.123051090139879 1.28079369731239 0.473684210526316 14.2 14 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.21687182052958e-08 3.68427361832679e-07 1.27995162387563 0.473372781065089 14.2 14 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.32532436678414e-06 5.50225183015562e-05 1.27952306864442 0.473214285714286 14.2 14 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 9.56677163971273e-11 9.07567736220747e-09 1.27820623529762 0.472727272727273 14.2 14 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 8.31088930830622e-07 1.64255492857219e-05 1.27743203406485 0.47244094488189 14.2 14 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.000189474916294856 0.00142657569252688 1.27684063034538 0.472222222222222 14.2 14 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00131365731310321 0.00724548200211575 1.27542349313079 0.471698113207547 14.2 14 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.66394873995818e-07 5.83199854916999e-06 1.27469467970614 0.471428571428571 14.2 14 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.66394873995818e-07 5.83199854916999e-06 1.27469467970614 0.471428571428571 14.2 14 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.69272131782275e-08 4.91580088828933e-07 1.27242249667636 0.470588235294118 14.2 14 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 5.92250831909451e-05 0.000558127770733212 1.27242249667636 0.470588235294118 14.2 14 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 5.92250831909451e-05 0.000558127770733212 1.27242249667636 0.470588235294118 14.2 14 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.000312821363671993 0.0021504579734553 1.27242249667636 0.470588235294118 14.2 14 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0609939682192975 0.153076572797285 1.27242249667636 0.470588235294118 14.2 14 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0609939682192975 0.153076572797285 1.27242249667636 0.470588235294118 14.2 14 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0609939682192975 0.153076572797285 1.27242249667636 0.470588235294118 14.2 14 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0609939682192975 0.153076572797285 1.27242249667636 0.470588235294118 14.2 14 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0609939682192975 0.153076572797285 1.27242249667636 0.470588235294118 14.2 14 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0609939682192975 0.153076572797285 1.27242249667636 0.470588235294118 14.2 14 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0609939682192975 0.153076572797285 1.27242249667636 0.470588235294118 14.2 14 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00169551061271278 0.00883777143549553 1.27242249667636 0.470588235294118 14.2 14 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00169551061271278 0.00883777143549553 1.27242249667636 0.470588235294118 14.2 14 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 5.48453165280793e-23 1.95112213548642e-20 1.26970106072815 0.46958174904943 14.2 14 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00218953543893399 0.010594157202802 1.26917652091954 0.469387755102041 14.2 14 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 9.73286111908984e-05 0.00081469772779205 1.26849526674835 0.469135802469136 14.2 14 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 7.55640476871395e-06 0.000112789754138451 1.26512649612203 0.467889908256881 14.2 14 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0163787942862872 0.056708088246683 1.26181897587073 0.466666666666667 14.2 14 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0163787942862872 0.056708088246683 1.26181897587073 0.466666666666667 14.2 14 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0815987423607209 0.185487237027645 1.26181897587073 0.466666666666667 14.2 14 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0815987423607209 0.185487237027645 1.26181897587073 0.466666666666667 14.2 14 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0815987423607209 0.185487237027645 1.26181897587073 0.466666666666667 14.2 14 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0815987423607209 0.185487237027645 1.26181897587073 0.466666666666667 14.2 14 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.53545584358919e-10 2.25497104089213e-08 1.26101063571963 0.466367713004484 14.2 14 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 8.20367717265652e-05 0.000720891356933168 1.2576268862499 0.465116279069767 14.2 14 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00473244081871423 0.0204068584394859 1.2576268862499 0.465116279069767 14.2 14 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.30610706864873e-06 5.50225183015562e-05 1.25302581227581 0.463414634146341 14.2 14 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000134480518502052 0.00106908255770067 1.25302581227581 0.463414634146341 14.2 14 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.0061271628107105 0.0245604300834959 1.25302581227581 0.463414634146341 14.2 14 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.0061271628107105 0.0245604300834959 1.25302581227581 0.463414634146341 14.2 14 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0061271628107105 0.0245604300834959 1.25302581227581 0.463414634146341 14.2 14 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.13678969092018e-12 7.27720977514952e-10 1.2525408951658 0.463235294117647 14.2 14 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.000556402754517393 0.00336919625395 1.25105719356053 0.462686567164179 14.2 14 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.000556402754517393 0.00336919625395 1.25105719356053 0.462686567164179 14.2 14 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.37620305514872e-07 3.31921516521462e-06 1.25055273501474 0.4625 14.2 14 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.87717703609575e-09 1.04045195041645e-07 1.24894327203531 0.461904761904762 14.2 14 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.16695868359554e-05 0.00026132052599631 1.24795283327874 0.461538461538462 14.2 14 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0023512390919247 0.0112653644033968 1.24795283327874 0.461538461538462 14.2 14 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.109880953466772 0.231268284587646 1.24795283327874 0.461538461538462 14.2 14 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.109880953466772 0.231268284587646 1.24795283327874 0.461538461538462 14.2 14 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.109880953466772 0.231268284587646 1.24795283327874 0.461538461538462 14.2 14 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.109880953466772 0.231268284587646 1.24795283327874 0.461538461538462 14.2 14 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.109880953466772 0.231268284587646 1.24795283327874 0.461538461538462 14.2 14 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.109880953466772 0.231268284587646 1.24795283327874 0.461538461538462 14.2 14 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.13041331930434e-06 2.16509967513631e-05 1.24496014063299 0.460431654676259 14.2 14 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.47506393850236e-07 3.44100981063746e-06 1.24412475710304 0.460122699386503 14.2 14 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00303028994235821 0.0140459367686506 1.24379299050115 0.46 14.2 14 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0102956826899502 0.0387586149941777 1.24233142411983 0.459459459459459 14.2 14 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0102956826899502 0.0387586149941777 1.24233142411983 0.459459459459459 14.2 14 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.38755908731836e-07 5.39285171627624e-06 1.24141219998064 0.459119496855346 14.2 14 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 5.75674060099846e-06 8.95909788195266e-05 1.24113341888924 0.459016393442623 14.2 14 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.000143865952528325 0.00111869535763828 1.24061193425946 0.458823529411765 14.2 14 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.000143865952528325 0.00111869535763828 1.24061193425946 0.458823529411765 14.2 14 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.000143865952528325 0.00111869535763828 1.24061193425946 0.458823529411765 14.2 14 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0368083928221246 0.105889030645421 1.23928649415875 0.458333333333333 14.2 14 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0368083928221246 0.105889030645421 1.23928649415875 0.458333333333333 14.2 14 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0368083928221246 0.105889030645421 1.23928649415875 0.458333333333333 14.2 14 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0133640575008592 0.0481444400600574 1.2360675681999 0.457142857142857 14.2 14 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.000119780425791155 0.000973985976576075 1.23177566692143 0.455555555555556 14.2 14 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00650408163078018 0.0256379727440449 1.22904445701694 0.454545454545455 14.2 14 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00650408163078018 0.0256379727440449 1.22904445701694 0.454545454545455 14.2 14 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0484290835691325 0.128040730129466 1.22904445701694 0.454545454545455 14.2 14 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.14922234939328 0.278627198812301 1.22904445701694 0.454545454545455 14.2 14 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.14922234939328 0.278627198812301 1.22904445701694 0.454545454545455 14.2 14 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.14922234939328 0.278627198812301 1.22904445701694 0.454545454545455 14.2 14 2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.14922234939328 0.278627198812301 1.22904445701694 0.454545454545455 14.2 14 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.14922234939328 0.278627198812301 1.22904445701694 0.454545454545455 14.2 14 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.64174002781045e-32 2.33619605957427e-29 1.22654187780582 0.453619909502262 14.2 14 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 0.000491499646921367 0.00313634079627401 1.22576700513156 0.453333333333333 14.2 14 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 0.000491499646921367 0.00313634079627401 1.22576700513156 0.453333333333333 14.2 14 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 0.000491499646921367 0.00313634079627401 1.22576700513156 0.453333333333333 14.2 14 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 0.000491499646921367 0.00313634079627401 1.22576700513156 0.453333333333333 14.2 14 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 0.000491499646921367 0.00313634079627401 1.22576700513156 0.453333333333333 14.2 14 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 7.03411413800784e-07 1.42993491691217e-05 1.22278181010221 0.452229299363057 14.2 14 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.00012675084082147 0.00101329464319636 1.22111513793941 0.451612903225806 14.2 14 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.000405773924541377 0.00268565718429014 1.21675401244677 0.45 14.2 14 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.00205050367381256 0.0100616094063285 1.21675401244677 0.45 14.2 14 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.00205050367381256 0.0100616094063285 1.21675401244677 0.45 14.2 14 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00205050367381256 0.0100616094063285 1.21675401244677 0.45 14.2 14 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.00205050367381256 0.0100616094063285 1.21675401244677 0.45 14.2 14 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.00205050367381256 0.0100616094063285 1.21675401244677 0.45 14.2 14 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.00205050367381256 0.0100616094063285 1.21675401244677 0.45 14.2 14 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.00205050367381256 0.0100616094063285 1.21675401244677 0.45 14.2 14 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.010848871170333 0.0405195372057318 1.21675401244677 0.45 14.2 14 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0638979468597224 0.157585404473804 1.21675401244677 0.45 14.2 14 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0638979468597224 0.157585404473804 1.21675401244677 0.45 14.2 14 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00530659342333753 0.0222926395861953 1.21399493305347 0.448979591836735 14.2 14 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.014022980222373 0.0501374393377808 1.20963849190615 0.447368421052632 14.2 14 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.014022980222373 0.0501374393377808 1.20963849190615 0.447368421052632 14.2 14 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 0.000334208249628249 0.00225392577829857 1.20880137184255 0.447058823529412 14.2 14 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 0.000542262076196867 0.00332602988977648 1.20173235797212 0.444444444444444 14.2 14 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 0.000542262076196867 0.00332602988977648 1.20173235797212 0.444444444444444 14.2 14 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.018136404320456 0.0607249490541385 1.20173235797212 0.444444444444444 14.2 14 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0383610080048466 0.107456130690742 1.20173235797212 0.444444444444444 14.2 14 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0383610080048466 0.107456130690742 1.20173235797212 0.444444444444444 14.2 14 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0845855741719615 0.191359732983627 1.20173235797212 0.444444444444444 14.2 14 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00137190093821867 0.0075375097879736 1.19744045669365 0.442857142857143 14.2 14 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.54196152268762e-05 0.000201303784108668 1.19714559324704 0.442748091603053 14.2 14 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.54196152268762e-05 0.000201303784108668 1.19714559324704 0.442748091603053 14.2 14 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.00274361236185965 0.0127586940879944 1.19680722535748 0.442622950819672 14.2 14 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.000114851326961071 0.000950194408520953 1.19595479855879 0.442307692307692 14.2 14 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00553485253587435 0.0230295180074538 1.19595479855879 0.442307692307692 14.2 14 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.00553485253587435 0.0230295180074538 1.19595479855879 0.442307692307692 14.2 14 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0234709229782568 0.0738918659249102 1.19289609063409 0.441176470588235 14.2 14 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0500994545587121 0.129857056169485 1.1897150343924 0.44 14.2 14 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0500994545587121 0.129857056169485 1.1897150343924 0.44 14.2 14 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.95879919504174e-05 0.000391236730963539 1.18707708531393 0.439024390243902 14.2 14 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.0145441211909071 0.0517724006330886 1.18707708531393 0.439024390243902 14.2 14 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.42310652164086e-09 1.20164889205593e-07 1.18555519161481 0.438461538461538 14.2 14 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.86016148779426e-17 5.81429971018746e-15 1.18485409451746 0.438202247191011 14.2 14 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.10639860050306e-07 2.71449173882044e-06 1.18456475285823 0.438095238095238 14.2 14 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.112408032842715 0.233513329540413 1.18295528987881 0.4375 14.2 14 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.112408032842715 0.233513329540413 1.18295528987881 0.4375 14.2 14 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.112408032842715 0.233513329540413 1.18295528987881 0.4375 14.2 14 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.112408032842715 0.233513329540413 1.18295528987881 0.4375 14.2 14 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.112408032842715 0.233513329540413 1.18295528987881 0.4375 14.2 14 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.112408032842715 0.233513329540413 1.18295528987881 0.4375 14.2 14 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 7.76240258071256e-11 7.88992776596712e-09 1.17777143672421 0.43558282208589 14.2 14 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.000742528506034943 0.00434822248595771 1.17699080942564 0.435294117647059 14.2 14 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.00230547008430024 0.0110833916552677 1.17560774149447 0.434782608695652 14.2 14 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.78375591224829e-05 0.000224073484075236 1.17231932823155 0.433566433566434 14.2 14 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0393858350860876 0.109679145454995 1.17168904902282 0.433333333333333 14.2 14 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 7.75096522739395e-06 0.000112789754138451 1.16605592859482 0.43125 14.2 14 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 0.00151210125985201 0.00815045489685383 1.163702852973 0.430379746835443 14.2 14 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 0.00151210125985201 0.00815045489685383 1.163702852973 0.430379746835443 14.2 14 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.00151210125985201 0.00815045489685383 1.163702852973 0.430379746835443 14.2 14 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.22584446714387e-05 0.000167728526610166 1.16128944207883 0.429487179487179 14.2 14 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0858833946731234 0.192543689833838 1.1588133451874 0.428571428571429 14.2 14 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0858833946731234 0.192543689833838 1.1588133451874 0.428571428571429 14.2 14 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0858833946731234 0.192543689833838 1.1588133451874 0.428571428571429 14.2 14 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0119367374420343 0.0435537881538843 1.1588133451874 0.428571428571429 14.2 14 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.031051072086305 0.0943807319742304 1.1588133451874 0.428571428571429 14.2 14 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.0510727407306911 0.131660344311184 1.1588133451874 0.428571428571429 14.2 14 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.150082008893263 0.278627198812301 1.1588133451874 0.428571428571429 14.2 14 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 8.93524692232999e-05 0.000765955203040698 1.15282464572907 0.426356589147287 14.2 14 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00601469377403733 0.0243843568104134 1.15248103182572 0.426229508196721 14.2 14 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.000112290837819178 0.000934443638694091 1.14968883065837 0.425196850393701 14.2 14 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0399949800503793 0.111157923069707 1.14710815988248 0.424242424242424 14.2 14 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 6.95386899218299e-06 0.000105269740168898 1.14571940908359 0.423728813559322 14.2 14 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.0662733372220294 0.160659214424102 1.14395676383885 0.423076923076923 14.2 14 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0662733372220294 0.160659214424102 1.14395676383885 0.423076923076923 14.2 14 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0662733372220294 0.160659214424102 1.14395676383885 0.423076923076923 14.2 14 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00311744140829749 0.014356372569603 1.13848328649991 0.421052631578947 14.2 14 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0314465109185151 0.0943807319742304 1.13848328649991 0.421052631578947 14.2 14 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00160320898298318 0.00851256112979502 1.13686612274067 0.420454545454545 14.2 14 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.00490179950165451 0.0210732951385328 1.13642081677799 0.420289855072464 14.2 14 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00250698946541192 0.0118127351300701 1.13496944919589 0.419753086419753 14.2 14 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 4.03553108836357e-05 0.000393326077995984 1.1338926280866 0.419354838709677 14.2 14 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0515182957547654 0.13232948530511 1.1338926280866 0.419354838709677 14.2 14 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 9.14057350716813e-06 0.000128782535650497 1.13152245118842 0.418478260869565 14.2 14 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.65633204234158e-19 4.71392099250414e-17 1.12864364221838 0.41741357234315 14.2 14 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 4.65222490992268e-10 3.71743230858378e-08 1.12782903114496 0.417112299465241 14.2 14 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0402758347761971 0.111344525437218 1.12662408559886 0.416666666666667 14.2 14 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0860560693846246 0.192543689833838 1.12662408559886 0.416666666666667 14.2 14 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0860560693846246 0.192543689833838 1.12662408559886 0.416666666666667 14.2 14 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.201527009201482 0.338595367438008 1.12662408559886 0.416666666666667 14.2 14 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.201527009201482 0.338595367438008 1.12662408559886 0.416666666666667 14.2 14 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.201527009201482 0.338595367438008 1.12662408559886 0.416666666666667 14.2 14 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.201527009201482 0.338595367438008 1.12662408559886 0.416666666666667 14.2 14 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.201527009201482 0.338595367438008 1.12662408559886 0.416666666666667 14.2 14 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.201527009201482 0.338595367438008 1.12662408559886 0.416666666666667 14.2 14 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.201527009201482 0.338595367438008 1.12662408559886 0.416666666666667 14.2 14 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.201527009201482 0.338595367438008 1.12662408559886 0.416666666666667 14.2 14 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00203896957119202 0.0100616094063285 1.12409234608066 0.415730337078652 14.2 14 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.35102410404789e-15 2.13611922228905e-13 1.1185642554375 0.413685847589425 14.2 14 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.00985125391006839 0.0372828040266684 1.11589433240268 0.412698412698413 14.2 14 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.00985125391006839 0.0372828040266684 1.11589433240268 0.412698412698413 14.2 14 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00320712988602756 0.0145342223815835 1.11336968459182 0.411764705882353 14.2 14 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00320712988602756 0.0145342223815835 1.11336968459182 0.411764705882353 14.2 14 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00320712988602756 0.0145342223815835 1.11336968459182 0.411764705882353 14.2 14 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00320712988602756 0.0145342223815835 1.11336968459182 0.411764705882353 14.2 14 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00320712988602756 0.0145342223815835 1.11336968459182 0.411764705882353 14.2 14 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.148397878079107 0.278627198812301 1.11336968459182 0.411764705882353 14.2 14 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.148397878079107 0.278627198812301 1.11336968459182 0.411764705882353 14.2 14 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.000449272863468282 0.00293263892071268 1.1120870006234 0.411290322580645 14.2 14 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0402968591708834 0.111344525437218 1.10929140735888 0.41025641025641 14.2 14 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0402968591708834 0.111344525437218 1.10929140735888 0.41025641025641 14.2 14 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.0124109419992338 0.0450529858798716 1.10815483829396 0.409836065573771 14.2 14 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0124109419992338 0.0450529858798716 1.10815483829396 0.409836065573771 14.2 14 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.111813302360502 0.233513329540413 1.10614001131525 0.409090909090909 14.2 14 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.111813302360502 0.233513329540413 1.10614001131525 0.409090909090909 14.2 14 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 5.22449593326082e-06 8.2605085700335e-05 1.10338430625467 0.408071748878924 14.2 14 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0197086771368635 0.0649200175133257 1.10158799480778 0.407407407407407 14.2 14 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0854630635588421 0.192543689833838 1.10158799480778 0.407407407407407 14.2 14 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.83930491273931e-05 0.000288595063630574 1.09845848345889 0.40625 14.2 14 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00628472874213677 0.0251212612361253 1.09524974397459 0.40506329113924 14.2 14 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 0.000867877749223926 0.00493996014858258 1.09496687988782 0.40495867768595 14.2 14 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 0.000867877749223926 0.00493996014858258 1.09496687988782 0.40495867768595 14.2 14 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.000867877749223926 0.00493996014858258 1.09496687988782 0.40495867768595 14.2 14 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.000293400605035073 0.00202674301439276 1.08155912217491 0.4 14.2 14 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.0195072668155539 0.0648571043890962 1.08155912217491 0.4 14.2 14 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0246576887090354 0.0769471294582399 1.08155912217491 0.4 14.2 14 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0507981101446968 0.131190037633219 1.08155912217491 0.4 14.2 14 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0507981101446968 0.131190037633219 1.08155912217491 0.4 14.2 14 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0652356519439053 0.159776820509771 1.08155912217491 0.4 14.2 14 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.110027145935233 0.231268284587646 1.08155912217491 0.4 14.2 14 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.110027145935233 0.231268284587646 1.08155912217491 0.4 14.2 14 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.110027145935233 0.231268284587646 1.08155912217491 0.4 14.2 14 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.110027145935233 0.231268284587646 1.08155912217491 0.4 14.2 14 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.145352937862406 0.278627198812301 1.08155912217491 0.4 14.2 14 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.145352937862406 0.278627198812301 1.08155912217491 0.4 14.2 14 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.145352937862406 0.278627198812301 1.08155912217491 0.4 14.2 14 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.195737519914958 0.338438020460492 1.08155912217491 0.4 14.2 14 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.195737519914958 0.338438020460492 1.08155912217491 0.4 14.2 14 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.195737519914958 0.338438020460492 1.08155912217491 0.4 14.2 14 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.195737519914958 0.338438020460492 1.08155912217491 0.4 14.2 14 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.000857410346351033 0.00493965555812761 1.07749311043741 0.398496240601504 14.2 14 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 5.19422094795163e-19 1.23189606815586e-16 1.07452195070931 0.397397397397397 14.2 14 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.0244118269935799 0.0763473182678335 1.07223533663892 0.396551724137931 14.2 14 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 0.000122048901175854 0.000986793104393409 1.0699916449324 0.39572192513369 14.2 14 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.00162193036332151 0.00851663065316053 1.06847574569699 0.395161290322581 14.2 14 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.00162193036332151 0.00851663065316053 1.06847574569699 0.395161290322581 14.2 14 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.00162193036332151 0.00851663065316053 1.06847574569699 0.395161290322581 14.2 14 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0828565340370306 0.188046009465223 1.06517186274802 0.393939393939394 14.2 14 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 4.94705054661709e-06 7.9097223908271e-05 1.06398866712153 0.393501805054152 14.2 14 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.41413099231234e-05 0.000188066205800043 1.06224556642179 0.392857142857143 14.2 14 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.41413099231234e-05 0.000188066205800043 1.06224556642179 0.392857142857143 14.2 14 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.41413099231234e-05 0.000188066205800043 1.06224556642179 0.392857142857143 14.2 14 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.107715625388823 0.229804100342271 1.06224556642179 0.392857142857143 14.2 14 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00385843759202254 0.0171579896670252 1.0613430638165 0.392523364485981 14.2 14 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.000535138423956836 0.00331087816213295 1.06102318947539 0.392405063291139 14.2 14 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.0075088393326141 0.0290355390497551 1.05804696734502 0.391304347826087 14.2 14 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.0188498881382623 0.0628182454818438 1.05804696734502 0.391304347826087 14.2 14 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0493004854612953 0.128253365285966 1.05804696734502 0.391304347826087 14.2 14 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.141562865495664 0.275950626849768 1.05804696734502 0.391304347826087 14.2 14 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00939550819262593 0.0357481501553655 1.05669569407893 0.390804597701149 14.2 14 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00939550819262593 0.0357481501553655 1.05669569407893 0.390804597701149 14.2 14 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.0117717595826122 0.0433130754948915 1.05517963139016 0.390243902439024 14.2 14 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.00593153005974134 0.0241159065000341 1.05452014412054 0.39 14.2 14 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 5.52938655797277e-25 3.93415853599763e-22 1.0473458252178 0.387346675274371 14.2 14 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 5.71265314514529e-10 4.27847653975881e-08 1.04651736427607 0.387040280210158 14.2 14 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0036004867984851 0.0161116123089443 1.04166554799633 0.385245901639344 14.2 14 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0792114358602599 0.181510262848873 1.03996069439895 0.384615384615385 14.2 14 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0792114358602599 0.181510262848873 1.03996069439895 0.384615384615385 14.2 14 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.137373276380985 0.26925919048229 1.03996069439895 0.384615384615385 14.2 14 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.137373276380985 0.26925919048229 1.03996069439895 0.384615384615385 14.2 14 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.258805794035676 0.415198021322172 1.03996069439895 0.384615384615385 14.2 14 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.258805794035676 0.415198021322172 1.03996069439895 0.384615384615385 14.2 14 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.258805794035676 0.415198021322172 1.03996069439895 0.384615384615385 14.2 14 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.258805794035676 0.415198021322172 1.03996069439895 0.384615384615385 14.2 14 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.102229452249895 0.220747360472839 1.03384327854955 0.382352941176471 14.2 14 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.102229452249895 0.220747360472839 1.03384327854955 0.382352941176471 14.2 14 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.102229452249895 0.220747360472839 1.03384327854955 0.382352941176471 14.2 14 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.22098759258482e-08 8.64804781933622e-07 1.03319672240286 0.382113821138211 14.2 14 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0463252645756899 0.124144729738619 1.03239734389423 0.381818181818182 14.2 14 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.0220727236990254 0.0696440927355057 1.03175047839054 0.381578947368421 14.2 14 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0220727236990254 0.0696440927355057 1.03175047839054 0.381578947368421 14.2 14 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.0357698624717354 0.105602726757841 1.03005630683325 0.380952380952381 14.2 14 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0357698624717354 0.105602726757841 1.03005630683325 0.380952380952381 14.2 14 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0771921517791492 0.177454655867091 1.03005630683325 0.380952380952381 14.2 14 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.181949579825041 0.318076476770311 1.03005630683325 0.380952380952381 14.2 14 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 7.48920974373017e-05 0.000683150350341541 1.02854151814673 0.380392156862745 14.2 14 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.000547382058499053 0.00334302433151997 1.02804447810896 0.380208333333333 14.2 14 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.0216034738676585 0.0690825692442205 1.02679663497618 0.379746835443038 14.2 14 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0452306546875163 0.122131350323218 1.02561640895897 0.379310344827586 14.2 14 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.0452306546875163 0.122131350323218 1.02561640895897 0.379310344827586 14.2 14 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0452306546875163 0.122131350323218 1.02561640895897 0.379310344827586 14.2 14 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0452306546875163 0.122131350323218 1.02561640895897 0.379310344827586 14.2 14 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.132988648762137 0.264501317368083 1.02561640895897 0.379310344827586 14.2 14 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0751045080687286 0.174916063800001 1.0214725042763 0.377777777777778 14.2 14 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0441099267020694 0.120016110319397 1.01950245123045 0.377049180327869 14.2 14 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00239895893851166 0.0114171189615455 1.01611446191592 0.375796178343949 14.2 14 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000754506678458585 0.00440025821084659 1.01567734823532 0.375634517766497 14.2 14 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0332555803873801 0.0994174178387433 1.01396167703898 0.375 14.2 14 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0729805127995782 0.170808009397697 1.01396167703898 0.375 14.2 14 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0729805127995782 0.170808009397697 1.01396167703898 0.375 14.2 14 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0729805127995782 0.170808009397697 1.01396167703898 0.375 14.2 14 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.174866943162288 0.313846323371062 1.01396167703898 0.375 14.2 14 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.174866943162288 0.313846323371062 1.01396167703898 0.375 14.2 14 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.174866943162288 0.313846323371062 1.01396167703898 0.375 14.2 14 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.174866943162288 0.313846323371062 1.01396167703898 0.375 14.2 14 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.0558182077170564 0.142601992067094 1.01396167703898 0.375 14.2 14 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.12853443139101 0.256888336895235 1.01396167703898 0.375 14.2 14 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.245735212158304 0.397817072697686 1.01396167703898 0.375 14.2 14 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.245735212158304 0.397817072697686 1.01396167703898 0.375 14.2 14 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.245735212158304 0.397817072697686 1.01396167703898 0.375 14.2 14 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0542696441076267 0.138895150297037 1.00823307999356 0.372881355932203 14.2 14 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.0117679133877354 0.0433130754948915 1.00781645475389 0.372727272727273 14.2 14 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.34576076867825e-06 2.51975996556466e-05 1.00638348812239 0.37219730941704 14.2 14 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.0146265795586354 0.0517724006330886 1.00430489916242 0.371428571428571 14.2 14 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.0406886511511515 0.112209206566063 1.00430489916242 0.371428571428571 14.2 14 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.12408942515798 0.252357971116955 1.00430489916242 0.371428571428571 14.2 14 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0186765870669897 0.0623868154843341 1.00350846387363 0.371134020618557 14.2 14 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.052722469051376 0.135178510738933 1.00305886330738 0.370967741935484 14.2 14 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.0687129879071127 0.166007778933483 1.00144363164344 0.37037037037037 14.2 14 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.167908695688128 0.305152074028361 1.00144363164344 0.37037037037037 14.2 14 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.167908695688128 0.305152074028361 1.00144363164344 0.37037037037037 14.2 14 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.167908695688128 0.305152074028361 1.00144363164344 0.37037037037037 14.2 14 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.0109093595503272 0.0406387922516116 0.999760533102858 0.369747899159664 14.2 14 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.090231004079983 0.198046403139308 0.999266580270297 0.369565217391304 14.2 14 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.090231004079983 0.198046403139308 0.999266580270297 0.369565217391304 14.2 14 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0666007450659925 0.161178333722632 0.996172875687417 0.368421052631579 14.2 14 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.119703741107846 0.246153791324372 0.996172875687417 0.368421052631579 14.2 14 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.233475988224705 0.379698664278578 0.996172875687417 0.368421052631579 14.2 14 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.233475988224705 0.379698664278578 0.996172875687417 0.368421052631579 14.2 14 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.233475988224705 0.379698664278578 0.996172875687417 0.368421052631579 14.2 14 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.0645173394400602 0.158289955212424 0.991429195327001 0.366666666666667 14.2 14 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.161152271363147 0.294755375513828 0.991429195327001 0.366666666666667 14.2 14 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.161152271363147 0.294755375513828 0.991429195327001 0.366666666666667 14.2 14 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.115409264063942 0.238702591225274 0.989230904428271 0.365853658536585 14.2 14 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.04669349681301 0.124661999934171 0.986557307389276 0.364864864864865 14.2 14 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.04669349681301 0.124661999934171 0.986557307389276 0.364864864864865 14.2 14 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.75048165690021e-06 4.77309194849878e-05 0.983235565613555 0.363636363636364 14.2 14 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.154636087021855 0.283931808815613 0.983235565613555 0.363636363636364 14.2 14 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.154636087021855 0.283931808815613 0.983235565613555 0.363636363636364 14.2 14 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.22202745266192 0.364832638727381 0.983235565613555 0.363636363636364 14.2 14 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.22202745266192 0.364832638727381 0.983235565613555 0.363636363636364 14.2 14 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.22202745266192 0.364832638727381 0.983235565613555 0.363636363636364 14.2 14 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.22202745266192 0.364832638727381 0.983235565613555 0.363636363636364 14.2 14 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00568816384036894 0.0231957675961889 0.974660836843669 0.36046511627907 14.2 14 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.0734072009428116 0.171524543418097 0.971713273829021 0.359375 14.2 14 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0994396346870495 0.216034504060567 0.9693218547794 0.358490566037736 14.2 14 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.0372842246927092 0.105889030645421 0.967710793524919 0.357894736842105 14.2 14 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.0372842246927092 0.105889030645421 0.967710793524919 0.357894736842105 14.2 14 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00147788789519481 0.00805760335196249 0.966453432465532 0.357429718875502 14.2 14 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.136640993111049 0.268563719885391 0.96567778765617 0.357142857142857 14.2 14 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.0957769531961859 0.208395419569071 0.965677787656169 0.357142857142857 14.2 14 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.201349290298854 0.338595367438008 0.965677787656169 0.357142857142857 14.2 14 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.201349290298854 0.338595367438008 0.965677787656169 0.357142857142857 14.2 14 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.319207896892571 0.470707603397024 0.965677787656169 0.357142857142857 14.2 14 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.319207896892571 0.470707603397024 0.965677787656169 0.357142857142857 14.2 14 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.319207896892571 0.470707603397024 0.965677787656169 0.357142857142857 14.2 14 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.319207896892571 0.470707603397024 0.965677787656169 0.357142857142857 14.2 14 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.319207896892571 0.470707603397024 0.965677787656169 0.357142857142857 14.2 14 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.319207896892571 0.470707603397024 0.965677787656169 0.357142857142857 14.2 14 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.319207896892571 0.470707603397024 0.965677787656169 0.357142857142857 14.2 14 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0922471230344007 0.20102244422351 0.962404303630216 0.355932203389831 14.2 14 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.0888479226247461 0.198046403139308 0.959447608380968 0.354838709677419 14.2 14 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.191995650938495 0.333997324309877 0.959447608380968 0.354838709677419 14.2 14 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.191995650938495 0.333997324309877 0.959447608380968 0.354838709677419 14.2 14 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.12591297223685 0.252357971116955 0.957630472759035 0.354166666666667 14.2 14 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.12591297223685 0.252357971116955 0.957630472759035 0.354166666666667 14.2 14 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.183221524170197 0.319907029318025 0.954316872507274 0.352941176470588 14.2 14 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.298828303474229 0.445736557488289 0.954316872507274 0.352941176470588 14.2 14 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.298828303474229 0.445736557488289 0.954316872507274 0.352941176470588 14.2 14 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.298828303474229 0.445736557488289 0.954316872507274 0.352941176470588 14.2 14 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.298828303474229 0.445736557488289 0.954316872507274 0.352941176470588 14.2 14 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.0363432289886881 0.105889030645421 0.95001814785634 0.351351351351351 14.2 14 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.174975851949157 0.313846323371062 0.95001814785634 0.351351351351351 14.2 14 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0514727287768644 0.13232948530511 0.949240718930107 0.351063829787234 14.2 14 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.280926861496713 0.436894998808549 0.946364231903046 0.35 14.2 14 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.280926861496713 0.436894998808549 0.946364231903046 0.35 14.2 14 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.264941899150589 0.42408585207119 0.940486193195574 0.347826086956522 14.2 14 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.264941899150589 0.42408585207119 0.940486193195574 0.347826086956522 14.2 14 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00539228961816217 0.0225683180195434 0.939981640516821 0.347639484978541 14.2 14 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.0915333821505122 0.199773010429722 0.93885340466572 0.347222222222222 14.2 14 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.0915333821505122 0.199773010429722 0.93885340466572 0.347222222222222 14.2 14 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0814795959055181 0.185487237027645 0.934680722867206 0.345679012345679 14.2 14 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.134388230820186 0.264501317368083 0.934073787332877 0.345454545454545 14.2 14 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.134388230820186 0.264501317368083 0.934073787332877 0.345454545454545 14.2 14 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.134388230820186 0.264501317368083 0.934073787332877 0.345454545454545 14.2 14 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.134388230820186 0.264501317368083 0.934073787332877 0.345454545454545 14.2 14 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.134388230820186 0.264501317368083 0.934073787332877 0.345454545454545 14.2 14 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.134388230820186 0.264501317368083 0.934073787332877 0.345454545454545 14.2 14 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.118503752648866 0.244747227894537 0.929464870619063 0.34375 14.2 14 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.225237242130035 0.368405282242575 0.929464870619063 0.34375 14.2 14 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.225237242130035 0.368405282242575 0.929464870619063 0.34375 14.2 14 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.113719186369042 0.235892714581846 0.928203724254587 0.343283582089552 14.2 14 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.214073054089614 0.353394380475082 0.927050676149923 0.342857142857143 14.2 14 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.0579677967030369 0.147300311979324 0.926335359270178 0.342592592592593 14.2 14 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.194074619482545 0.337201689284081 0.923282177466387 0.341463414634146 14.2 14 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.0859090955943673 0.192543689833838 0.921783342762707 0.340909090909091 14.2 14 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.0387538086246647 0.108343162422196 0.920475848659498 0.340425531914894 14.2 14 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0735615916315679 0.171603516215936 0.919325253848673 0.34 14.2 14 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.168703451883251 0.306205372487074 0.919325253848673 0.34 14.2 14 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0338403527084767 0.100953505040173 0.912358155208896 0.337423312883436 14.2 14 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.101272377371567 0.219680782011798 0.911779492531174 0.337209302325581 14.2 14 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0392491767698034 0.109512899104765 0.906897400581446 0.335403726708075 14.2 14 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.118974053855325 0.245007349690489 0.901299268479092 0.333333333333333 14.2 14 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.118974053855325 0.245007349690489 0.901299268479092 0.333333333333333 14.2 14 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.222791432668294 0.365244480054127 0.901299268479092 0.333333333333333 14.2 14 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.275416727295694 0.429263968172807 0.901299268479092 0.333333333333333 14.2 14 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.275416727295694 0.429263968172807 0.901299268479092 0.333333333333333 14.2 14 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.275416727295694 0.429263968172807 0.901299268479092 0.333333333333333 14.2 14 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.380943085381378 0.538848916995727 0.901299268479092 0.333333333333333 14.2 14 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.380943085381378 0.538848916995727 0.901299268479092 0.333333333333333 14.2 14 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.380943085381378 0.538848916995727 0.901299268479092 0.333333333333333 14.2 14 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.380943085381378 0.538848916995727 0.901299268479092 0.333333333333333 14.2 14 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.380943085381378 0.538848916995727 0.901299268479092 0.333333333333333 14.2 14 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0437907649206783 0.119375974103688 0.901299268479092 0.333333333333333 14.2 14 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.124014631395517 0.252357971116955 0.901299268479092 0.333333333333333 14.2 14 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.140773537052563 0.27478839948669 0.901299268479092 0.333333333333333 14.2 14 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.234386308356711 0.380743968940183 0.901299268479092 0.333333333333333 14.2 14 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.353739601292244 0.511037007755191 0.901299268479092 0.333333333333333 14.2 14 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.353739601292244 0.511037007755191 0.901299268479092 0.333333333333333 14.2 14 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.114176939120527 0.23649750271981 0.901299268479091 0.333333333333333 14.2 14 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.128071302887622 0.256322734189995 0.891057231337284 0.329545454545455 14.2 14 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.133524562626952 0.264501317368083 0.890695747673455 0.329411764705882 14.2 14 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.133524562626952 0.264501317368083 0.890695747673455 0.329411764705882 14.2 14 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.151666808613079 0.279562006031621 0.889440067578051 0.328947368421053 14.2 14 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.158382995396528 0.290436858826365 0.88895270315746 0.328767123287671 14.2 14 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.165477217867979 0.301889847469403 0.888423564643676 0.328571428571429 14.2 14 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.207852255026826 0.344323351458876 0.884912009052199 0.327272727272727 14.2 14 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0644174882842714 0.158289955212424 0.884293621904014 0.327044025157233 14.2 14 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0644174882842714 0.158289955212424 0.884293621904014 0.327044025157233 14.2 14 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.13155205466995 0.262182876464059 0.882324547037426 0.326315789473684 14.2 14 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.13155205466995 0.262182876464059 0.882324547037426 0.326315789473684 14.2 14 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.14909458309507 0.278627198812301 0.880338820374927 0.325581395348837 14.2 14 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.253155890173536 0.40843631713939 0.880338820374927 0.325581395348837 14.2 14 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.185179145222221 0.322928828003947 0.875910556690948 0.323943661971831 14.2 14 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.297515178408179 0.445646419868251 0.874790466465001 0.323529411764706 14.2 14 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0843407971233117 0.191109799851071 0.872225098528153 0.32258064516129 14.2 14 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.152279733733533 0.280328668955779 0.872225098528153 0.32258064516129 14.2 14 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.31514104937055 0.468106172499262 0.872225098528153 0.32258064516129 14.2 14 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.31514104937055 0.468106172499262 0.872225098528153 0.32258064516129 14.2 14 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.257248542720657 0.414569282323325 0.865247297739928 0.32 14.2 14 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.356398223282261 0.512277446192583 0.865247297739928 0.32 14.2 14 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.356398223282261 0.512277446192583 0.865247297739928 0.32 14.2 14 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.356398223282261 0.512277446192583 0.865247297739928 0.32 14.2 14 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.356398223282261 0.512277446192583 0.865247297739928 0.32 14.2 14 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.150963858246159 0.278627198812301 0.86033111991186 0.318181818181818 14.2 14 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.208572955210206 0.34511548286526 0.85566386248015 0.316455696202532 14.2 14 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.409245884246492 0.564906624101756 0.853862464874929 0.315789473684211 14.2 14 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.138821442628372 0.27135015502771 0.849796453137429 0.314285714285714 14.2 14 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.301749158109261 0.449493316359458 0.844968064199148 0.3125 14.2 14 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.356006416298057 0.512277446192583 0.844968064199148 0.3125 14.2 14 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.442401209573685 0.605906565181284 0.844968064199148 0.3125 14.2 14 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.442401209573685 0.605906565181284 0.844968064199148 0.3125 14.2 14 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.442401209573685 0.605906565181284 0.844968064199148 0.3125 14.2 14 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.378421243217402 0.537955473624738 0.839140698239154 0.310344827586207 14.2 14 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.163864151832255 0.299330793398329 0.837827489008733 0.309859154929577 14.2 14 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.301978644019425 0.449493316359458 0.835750230771521 0.309090909090909 14.2 14 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.213617885687837 0.353052556717528 0.833912407284393 0.308411214953271 14.2 14 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.138688763217409 0.27135015502771 0.833092837350944 0.308108108108108 14.2 14 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.222438988312349 0.365087289929034 0.831968555519161 0.307692307692308 14.2 14 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.403465065806762 0.564906624101756 0.831968555519161 0.307692307692308 14.2 14 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.403465065806762 0.564906624101756 0.831968555519161 0.307692307692308 14.2 14 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.348727760479898 0.504821569850351 0.816271035603706 0.30188679245283 14.2 14 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.2300519808123 0.375417395293467 0.815145661933296 0.301470588235294 14.2 14 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.464239751139255 0.617142220177152 0.811169341631182 0.3 14.2 14 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.246668866221484 0.39842201660973 0.809195693598017 0.299270072992701 14.2 14 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.246668866221484 0.39842201660973 0.809195693598017 0.299270072992701 14.2 14 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.226520447212688 0.370078755893977 0.807871905283088 0.298780487804878 14.2 14 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.386062989643258 0.545548792713362 0.805416367577061 0.297872340425532 14.2 14 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.358401023410756 0.514636383767412 0.802719660989191 0.296875 14.2 14 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.450485138332076 0.613977830022123 0.801154905314748 0.296296296296296 14.2 14 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.450485138332076 0.613977830022123 0.801154905314748 0.296296296296296 14.2 14 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.502223253781791 0.656256832076666 0.795264060422728 0.294117647058824 14.2 14 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.502223253781791 0.656256832076666 0.795264060422728 0.294117647058824 14.2 14 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.481919814651511 0.632862513695589 0.788636859919205 0.291666666666667 14.2 14 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.481919814651511 0.632862513695589 0.788636859919205 0.291666666666667 14.2 14 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.324573889600621 0.478124891202571 0.787749754339994 0.291338582677165 14.2 14 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.466512621094483 0.617142220177152 0.785002588675338 0.290322580645161 14.2 14 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.44307668448197 0.606248194247926 0.781126032681879 0.288888888888889 14.2 14 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.49682564825509 0.650997143155611 0.772542230124936 0.285714285714286 14.2 14 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.530733766850664 0.679636741951687 0.757091385522437 0.28 14.2 14 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.500229465892863 0.654854213399765 0.751082723732576 0.277777777777778 14.2 14 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.559332350893156 0.706864951439575 0.751082723732576 0.277777777777778 14.2 14 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.559332350893156 0.706864951439575 0.751082723732576 0.277777777777778 14.2 14 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.559332350893156 0.706864951439575 0.751082723732576 0.277777777777778 14.2 14 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.569059272593097 0.717882397960973 0.737426674210166 0.272727272727273 14.2 14 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.560775066463219 0.708059378506798 0.730783190658723 0.27027027027027 14.2 14 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.577622235656313 0.728039363453439 0.727972486079266 0.269230769230769 14.2 14 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.585337925547327 0.737111387658271 0.721039414783273 0.266666666666667 14.2 14 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.602077546248436 0.744361923155696 0.709219096508138 0.262295081967213 14.2 14 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.617514126315825 0.751687426644499 0.70536464489668 0.260869565217391 14.2 14 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.622120219719796 0.756647070650657 0.701010542150405 0.259259259259259 14.2 14 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.626668466226578 0.760229520409565 0.697780078822522 0.258064516129032 14.2 14 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.626668466226578 0.760229520409565 0.697780078822522 0.258064516129032 14.2 14 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.626668466226578 0.760229520409565 0.697780078822522 0.258064516129032 14.2 14 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.631121269156044 0.764328141284299 0.695288007112442 0.257142857142857 14.2 14 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.631121269156044 0.764328141284299 0.695288007112442 0.257142857142857 14.2 14 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.924980273698839 1 0.693780607639028 0.256585365853659 14.2 14 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.663885076874698 0.798670127362915 0.675974451359319 0.25 14.2 14 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.662499630166677 0.798670127362915 0.675974451359319 0.25 14.2 14 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.662499630166677 0.798670127362915 0.675974451359319 0.25 14.2 14 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.815021947087099 0.926338842416087 0.668021810755091 0.247058823529412 14.2 14 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.713412781059802 0.838591058194641 0.666177720180198 0.246376811594203 14.2 14 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.704979347769641 0.838083217941687 0.662179054392802 0.244897959183673 14.2 14 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.707727811261908 0.838591058194641 0.64378519177078 0.238095238095238 14.2 14 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.707727811261908 0.838591058194641 0.64378519177078 0.238095238095238 14.2 14 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.742419860892186 0.865607931331758 0.623976416639371 0.230769230769231 14.2 14 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.784901161481941 0.906756822565019 0.587803870747234 0.217391304347826 14.2 14 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.826994311121457 0.938447292444843 0.57355407994124 0.212121212121212 14.2 14 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.826994311121457 0.938447292444843 0.57355407994124 0.212121212121212 14.2 14 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.996884407665547 1 0.571442319705816 0.211340206185567 14.2 14 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.843836784873572 0.951663965423655 0.569241643249953 0.210526315789474 14.2 14 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.883226114202873 0.985749616086815 0.561186336977548 0.207547169811321 14.2 14 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.850638948595215 0.953117499095269 0.55668484229591 0.205882352941176 14.2 14 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.984495471496288 1 0.55240922906783 0.204301075268817 14.2 14 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.995961265438556 1 0.550436338964017 0.203571428571429 14.2 14 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.950718204674708 1 0.540779561087455 0.2 14.2 14 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.914543793108035 1 0.491617782806777 0.181818181818182 14.2 14 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999628034775418 1 0.473493624915283 0.175115207373272 14.2 14 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.967702667167966 1 0.450649634239546 0.166666666666667 14.2 14 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.99042711383191 1 0.444945208489678 0.164556962025316 14.2 14 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.996215512721964 1 0.436993584717135 0.161616161616162 14.2 14 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99992194638928 1 0.414802504243218 0.153409090909091 14.2 14 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.381406239557903 0.141057934508816 14.2 14 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999954334525312 1 0.325469180284116 0.12037037037037 14.2 14 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.308038990492854 0.113924050632911 14.2 14 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.999660083494717 1 0.304664541457721 0.112676056338028 14.2 14 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.9999372066427 1 0.300433089493031 0.111111111111111 14.2 14 2 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.000137711087971171 0.00204127998107267 3.39942938659059 1 14.1 14 1 SPERM MOTILITY AND TAXES%REACTOME%REACT_196630.2 SPERM MOTILITY AND TAXES 0.000200525406801302 0.00264210790628012 2.97450071326676 0.875 14.1 14 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000200525406801302 0.00264210790628012 2.97450071326676 0.875 14.1 14 1 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.00294836830234048 0.0230523521661016 2.83285782215882 0.833333333333333 14.1 14 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 5.62235010874435e-05 0.00105271107957148 2.78135131630139 0.818181818181818 14.1 14 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 8.99722934365621e-08 5.33460723167616e-06 2.62683179872909 0.772727272727273 14.1 14 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 8.99722934365621e-08 5.33460723167616e-06 2.62683179872909 0.772727272727273 14.1 14 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000179169048478277 0.00247531607752027 2.54957203994294 0.75 14.1 14 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00250353719144067 0.0207124036245353 2.54957203994294 0.75 14.1 14 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00837859317578881 0.0500635144499374 2.4281638475647 0.714285714285714 14.1 14 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00606316933480559 0.039217681651947 2.26628625772706 0.666666666666667 14.1 14 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00606316933480559 0.039217681651947 2.26628625772706 0.666666666666667 14.1 14 1 INTERACTION WITH THE ZONA PELLUCIDA%REACTOME%REACT_199072.2 INTERACTION WITH THE ZONA PELLUCIDA 0.00606316933480559 0.039217681651947 2.26628625772706 0.666666666666667 14.1 14 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00428048416343061 0.0307632775987967 2.16327324601219 0.636363636363636 14.1 14 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00428048416343061 0.0307632775987967 2.16327324601219 0.636363636363636 14.1 14 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00428048416343061 0.0307632775987967 2.16327324601219 0.636363636363636 14.1 14 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0181703531497024 0.0839493913377484 2.12464336661912 0.625 14.1 14 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0181703531497024 0.0839493913377484 2.12464336661912 0.625 14.1 14 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0181703531497024 0.0839493913377484 2.12464336661912 0.625 14.1 14 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0181703531497024 0.0839493913377484 2.12464336661912 0.625 14.1 14 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0181703531497024 0.0839493913377484 2.12464336661912 0.625 14.1 14 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.012252772948976 0.0653022318591491 2.03965763195435 0.6 14.1 14 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.012252772948976 0.0653022318591491 2.03965763195435 0.6 14.1 14 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 6.694828302452e-05 0.00122137700953708 2.03965763195435 0.6 14.1 14 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 6.694828302452e-05 0.00122137700953708 2.03965763195435 0.6 14.1 14 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.000124968000762297 0.00191214478585751 1.96120926149457 0.576923076923077 14.1 14 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000124968000762297 0.00191214478585751 1.96120926149457 0.576923076923077 14.1 14 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000679741257727237 0.00700921601265115 1.94253107805176 0.571428571428571 14.1 14 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000679741257727237 0.00700921601265115 1.94253107805176 0.571428571428571 14.1 14 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000679741257727237 0.00700921601265115 1.94253107805176 0.571428571428571 14.1 14 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00558466688626568 0.0371354251362433 1.94253107805176 0.571428571428571 14.1 14 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.0239482020183e-07 5.82831316588814e-06 1.92420531316448 0.566037735849057 14.1 14 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00378094486277907 0.0280223153111178 1.9121790299572 0.5625 14.1 14 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00378094486277907 0.0280223153111178 1.9121790299572 0.5625 14.1 14 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.02249727213322e-05 0.000496209244525099 1.88857188143921 0.555555555555556 14.1 14 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00022213707845689 0.00282233091646567 1.88857188143921 0.555555555555556 14.1 14 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00022213707845689 0.00282233091646567 1.88857188143921 0.555555555555556 14.1 14 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0333043329183234 0.1298412760076 1.88857188143921 0.555555555555556 14.1 14 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0333043329183234 0.1298412760076 1.88857188143921 0.555555555555556 14.1 14 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0333043329183234 0.1298412760076 1.88857188143921 0.555555555555556 14.1 14 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0333043329183234 0.1298412760076 1.88857188143921 0.555555555555556 14.1 14 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0333043329183234 0.1298412760076 1.88857188143921 0.555555555555556 14.1 14 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00174336238982237 0.0154871221061376 1.86968616262482 0.55 14.1 14 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00174336238982237 0.0154871221061376 1.86968616262482 0.55 14.1 14 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.03508791042524e-09 1.93062006435674e-07 1.85835473133619 0.546666666666667 14.1 14 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00118703423197667 0.011336575249012 1.85423421086759 0.545454545454545 14.1 14 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0218195194916304 0.0961274806086379 1.85423421086759 0.545454545454545 14.1 14 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0218195194916304 0.0961274806086379 1.85423421086759 0.545454545454545 14.1 14 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0218195194916304 0.0961274806086379 1.85423421086759 0.545454545454545 14.1 14 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0218195194916304 0.0961274806086379 1.85423421086759 0.545454545454545 14.1 14 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0218195194916304 0.0961274806086379 1.85423421086759 0.545454545454545 14.1 14 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0218195194916304 0.0961274806086379 1.85423421086759 0.545454545454545 14.1 14 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 3.25096619125326e-06 0.000112832314393985 1.84751597097314 0.543478260869565 14.1 14 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.50337347609199e-07 6.2920601661144e-06 1.84375831137116 0.542372881355932 14.1 14 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.50337347609199e-07 6.2920601661144e-06 1.84375831137116 0.542372881355932 14.1 14 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0144245115261491 0.0741263262086149 1.83046197739493 0.538461538461538 14.1 14 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0144245115261491 0.0741263262086149 1.83046197739493 0.538461538461538 14.1 14 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0096013087680505 0.0555757175790134 1.81302900618165 0.533333333333333 14.1 14 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000121780677191635 0.00191214478585751 1.79969791054796 0.529411764705882 14.1 14 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00642541007230519 0.0402586685750257 1.79969791054796 0.529411764705882 14.1 14 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00642541007230519 0.0402586685750257 1.79969791054796 0.529411764705882 14.1 14 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00642541007230519 0.0402586685750257 1.79969791054796 0.529411764705882 14.1 14 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 3.95482276381318e-05 0.000879330123891586 1.78470042796006 0.525 14.1 14 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00291334563512702 0.0229043692750594 1.78065348821412 0.523809523809524 14.1 14 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.37958213492096e-07 6.2920601661144e-06 1.77582132135329 0.522388059701492 14.1 14 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.37958213492096e-07 6.2920601661144e-06 1.77582132135329 0.522388059701492 14.1 14 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.49259944677131e-10 2.95580751062965e-08 1.76909080322571 0.520408163265306 14.1 14 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000909118311167466 0.00906766718380746 1.76266708934327 0.518518518518518 14.1 14 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000422564481970657 0.00492876440855938 1.75454419953062 0.516129032258065 14.1 14 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 4.380294129861e-05 0.000958947468737261 1.73924294197658 0.511627906976744 14.1 14 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 6.37282431059681e-10 6.47752070998518e-08 1.7337089871612 0.51 14.1 14 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.8389284093083e-06 0.000280015902528914 1.73304243237951 0.509803921568627 14.1 14 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.8389284093083e-06 0.000280015902528914 1.73304243237951 0.509803921568627 14.1 14 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.35867056193978e-10 3.67645246895409e-08 1.71559987734478 0.504672897196262 14.1 14 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00313288280246457 0.0242287621081907 1.69971469329529 0.5 14.1 14 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0353737033704219 0.134590320577835 1.69971469329529 0.5 14.1 14 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0353737033704219 0.134590320577835 1.69971469329529 0.5 14.1 14 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0353737033704219 0.134590320577835 1.69971469329529 0.5 14.1 14 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0353737033704219 0.134590320577835 1.69971469329529 0.5 14.1 14 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 4.73206312714145e-05 0.00102026148938216 1.69971469329529 0.5 14.1 14 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00031156859814518 0.00380690585888855 1.69971469329529 0.5 14.1 14 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.000979646392004219 0.00961404700566899 1.69971469329529 0.5 14.1 14 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00144010654897663 0.0134820501262747 1.69971469329529 0.5 14.1 14 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00463965703827737 0.0315850717455622 1.69971469329529 0.5 14.1 14 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.010285870166962 0.0580825128872495 1.69971469329529 0.5 14.1 14 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0543558928876708 0.184602471549297 1.69971469329529 0.5 14.1 14 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0543558928876708 0.184602471549297 1.69971469329529 0.5 14.1 14 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0543558928876708 0.184602471549297 1.69971469329529 0.5 14.1 14 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0543558928876708 0.184602471549297 1.69971469329529 0.5 14.1 14 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.015421672673322 0.0743899668275835 1.69971469329529 0.5 14.1 14 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 5.00881899289146e-05 0.00103226699293882 1.66502663833008 0.489795918367347 14.1 14 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 7.28019243037432e-05 0.00131135618081299 1.66355055088475 0.48936170212766 14.1 14 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.06099517025483e-07 8.14665590909063e-06 1.65825823736126 0.48780487804878 14.1 14 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000699574229280383 0.00714429804733092 1.651151416344 0.485714285714286 14.1 14 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.67155059840859e-08 1.32145361196413e-06 1.64820818743786 0.484848484848485 14.1 14 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.49488468886266e-07 6.2920601661144e-06 1.64110384180235 0.482758620689655 14.1 14 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.49488468886266e-07 6.2920601661144e-06 1.64110384180235 0.482758620689655 14.1 14 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 3.10687650156808e-07 1.19488790857605e-05 1.63827922245329 0.481927710843373 14.1 14 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 5.21278516427084e-05 0.00103226699293882 1.63434105124547 0.480769230769231 14.1 14 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 5.21278516427084e-05 0.00103226699293882 1.63434105124547 0.480769230769231 14.1 14 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00708573163190412 0.0429063664348918 1.62581405445637 0.478260869565217 14.1 14 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0105132853184157 0.0591320356051605 1.61877589837647 0.476190476190476 14.1 14 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 2.5535663855179e-05 0.000596135268467069 1.61328852244977 0.474576271186441 14.1 14 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0015295569199708 0.0140423193362481 1.59973147604263 0.470588235294118 14.1 14 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0234183505408924 0.0999904971281033 1.59973147604263 0.470588235294118 14.1 14 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0234183505408924 0.0999904971281033 1.59973147604263 0.470588235294118 14.1 14 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0234183505408924 0.0999904971281033 1.59973147604263 0.470588235294118 14.1 14 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.247405031654e-05 0.000321700001157783 1.59670168158043 0.46969696969697 14.1 14 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0352195226392666 0.134590320577835 1.58640038040894 0.466666666666667 14.1 14 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 6.08357194795733e-06 0.000196748247316893 1.58329587868603 0.465753424657534 14.1 14 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.08357194795733e-06 0.000196748247316893 1.58329587868603 0.465753424657534 14.1 14 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 5.42222845573677e-05 0.00103226699293882 1.58249299030941 0.46551724137931 14.1 14 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 5.42222845573677e-05 0.00103226699293882 1.58249299030941 0.46551724137931 14.1 14 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 7.83485280971882e-05 0.00134325247569035 1.57830650091706 0.464285714285714 14.1 14 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000113245839217993 0.00181066100232813 1.57380990119934 0.462962962962963 14.1 14 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00707812346472532 0.0429063664348918 1.56896740919565 0.461538461538462 14.1 14 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0533301535226559 0.183306300634636 1.56896740919565 0.461538461538462 14.1 14 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0533301535226559 0.183306300634636 1.56896740919565 0.461538461538462 14.1 14 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0533301535226559 0.183306300634636 1.56896740919565 0.461538461538462 14.1 14 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0533301535226559 0.183306300634636 1.56896740919565 0.461538461538462 14.1 14 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.77488171340265e-05 0.000852643917170154 1.56481670176392 0.46031746031746 14.1 14 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 5.4406201314414e-05 0.00103226699293882 1.56039381679568 0.459016393442623 14.1 14 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.4406201314414e-05 0.00103226699293882 1.56039381679568 0.459016393442623 14.1 14 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.26600141003766e-05 0.000321700001157783 1.55807180218735 0.458333333333333 14.1 14 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.26600141003766e-05 0.000321700001157783 1.55807180218735 0.458333333333333 14.1 14 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.26600141003766e-05 0.000321700001157783 1.55807180218735 0.458333333333333 14.1 14 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 1.82019036873283e-05 0.000454408928895933 1.55402486244141 0.457142857142857 14.1 14 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.32094451410172e-10 1.83029343216074e-08 1.55098965763195 0.45625 14.1 14 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000163045997236605 0.00227465151046754 1.54519517572299 0.454545454545455 14.1 14 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0154079755518644 0.0743899668275835 1.54519517572299 0.454545454545455 14.1 14 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0154079755518644 0.0743899668275835 1.54519517572299 0.454545454545455 14.1 14 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.081469537384371 0.252024242821652 1.54519517572299 0.454545454545455 14.1 14 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.081469537384371 0.252024242821652 1.54519517572299 0.454545454545455 14.1 14 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.081469537384371 0.252024242821652 1.54519517572299 0.454545454545455 14.1 14 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.081469537384371 0.252024242821652 1.54519517572299 0.454545454545455 14.1 14 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.31881229933814e-10 1.83029343216074e-08 1.54329923072211 0.45398773006135 14.1 14 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 6.45940870817766e-11 1.31310551310526e-08 1.53974154569103 0.452941176470588 14.1 14 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000235149439241871 0.00296121815965648 1.53936425053159 0.452830188679245 14.1 14 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.78052454194979e-05 0.00134325247569035 1.5352261745893 0.451612903225806 14.1 14 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000111882034081747 0.00180918334657189 1.52974322396576 0.45 14.1 14 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0228250917497404 0.0987237251060199 1.52974322396576 0.45 14.1 14 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0228250917497404 0.0987237251060199 1.52974322396576 0.45 14.1 14 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0228250917497404 0.0987237251060199 1.52974322396576 0.45 14.1 14 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.30224752952668e-10 1.83029343216074e-08 1.52873747562654 0.449704142011834 14.1 14 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 5.33995571496746e-05 0.00103226699293882 1.52213256115996 0.447761194029851 14.1 14 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.89948489208446e-08 1.42261421128221e-06 1.51944192279428 0.446969696969697 14.1 14 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.55546390558617e-05 0.000596135268467069 1.51596175347958 0.445945945945946 14.1 14 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.55546390558617e-05 0.000596135268467069 1.51596175347958 0.445945945945946 14.1 14 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.12966586408067e-07 6.18274817148765e-06 1.51403157554034 0.445378151260504 14.1 14 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.000109850388047876 0.00180918334657189 1.51085750515137 0.444444444444444 14.1 14 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000332672319260972 0.0040118026297319 1.51085750515137 0.444444444444444 14.1 14 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00317389175191499 0.0244132322322975 1.51085750515137 0.444444444444444 14.1 14 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0101428252963773 0.0575029497878282 1.51085750515137 0.444444444444444 14.1 14 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0339243348400367 0.131537679774856 1.51085750515137 0.444444444444444 14.1 14 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000157524607161688 0.00221938134644636 1.50466546619583 0.442622950819672 14.1 14 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000478351106318744 0.00519613453657689 1.50359376714584 0.442307692307692 14.1 14 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00147096082259604 0.0136101767151036 1.50207344988886 0.441860465116279 14.1 14 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.61262185784041e-14 4.58952180741381e-12 1.49783287148627 0.440613026819923 14.1 14 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.014861884405485 0.0741263262086149 1.49574893009986 0.44 14.1 14 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00212347693910794 0.0182030583394614 1.49243241362513 0.439024390243902 14.1 14 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000153205163498095 0.00220213078442211 1.48725035663338 0.4375 14.1 14 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00669187432509759 0.0412231046087181 1.48725035663338 0.4375 14.1 14 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0506178503905569 0.180623504843061 1.48725035663338 0.4375 14.1 14 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0506178503905569 0.180623504843061 1.48725035663338 0.4375 14.1 14 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0506178503905569 0.180623504843061 1.48725035663338 0.4375 14.1 14 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.000463995923408872 0.00507897076162173 1.48338736869407 0.436363636363636 14.1 14 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000463995923408872 0.00507897076162173 1.48338736869407 0.436363636363636 14.1 14 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000463995923408872 0.00507897076162173 1.48338736869407 0.436363636363636 14.1 14 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.000463995923408872 0.00507897076162173 1.48338736869407 0.436363636363636 14.1 14 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000463995923408872 0.00507897076162173 1.48338736869407 0.436363636363636 14.1 14 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.00142141937786183 0.0133952302960091 1.47801277677852 0.434782608695652 14.1 14 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0218097016441415 0.0961274806086379 1.47801277677852 0.434782608695652 14.1 14 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0218097016441415 0.0961274806086379 1.47801277677852 0.434782608695652 14.1 14 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0218097016441415 0.0961274806086379 1.47801277677852 0.434782608695652 14.1 14 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 4.94507138393225e-05 0.00103226699293882 1.47606802312486 0.434210526315789 14.1 14 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.13073635576973e-05 0.000309430352742369 1.47308606752259 0.433333333333333 14.1 14 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.000313006314469403 0.00380690585888855 1.47308606752259 0.433333333333333 14.1 14 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0097247741933762 0.0555757175790134 1.47308606752259 0.433333333333333 14.1 14 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.0097247741933762 0.0555757175790134 1.47308606752259 0.433333333333333 14.1 14 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00442656858457677 0.0313383437604614 1.47002351852566 0.432432432432432 14.1 14 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00442656858457677 0.0313383437604614 1.47002351852566 0.432432432432432 14.1 14 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.56375789457136e-21 1.69040916132502e-18 1.46829813880908 0.431924882629108 14.1 14 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00204293494419198 0.0176187662156678 1.46793541693684 0.431818181818182 14.1 14 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00204293494419198 0.0176187662156678 1.46793541693684 0.431818181818182 14.1 14 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000952224166600268 0.00940982631300126 1.46642051970574 0.431372549019608 14.1 14 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.60041064519246e-15 3.05959608702722e-12 1.46187065771472 0.430034129692833 14.1 14 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.000300901409849008 0.00372332788013164 1.45689830853882 0.428571428571429 14.1 14 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0320589465732339 0.1270748773641 1.45689830853882 0.428571428571429 14.1 14 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0758795015401235 0.243739346933625 1.45689830853882 0.428571428571429 14.1 14 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0758795015401235 0.243739346933625 1.45689830853882 0.428571428571429 14.1 14 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0758795015401235 0.243739346933625 1.45689830853882 0.428571428571429 14.1 14 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000911227271457812 0.00906766718380746 1.4479051091034 0.425925925925926 14.1 14 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00421681233401598 0.0307632775987967 1.444757489301 0.425 14.1 14 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.00689383668827e-05 0.000280943123452434 1.44218216400813 0.424242424242424 14.1 14 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.43952779993689e-24 6.31744805931019e-21 1.44120295287015 0.423954372623574 14.1 14 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00060985783225711 0.00647632608434229 1.44043618075872 0.423728813559322 14.1 14 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0205699757620421 0.0935178131290285 1.43822012509602 0.423076923076923 14.1 14 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0205699757620421 0.0935178131290285 1.43822012509602 0.423076923076923 14.1 14 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.00279112966428962 0.0220654306238007 1.4353146298938 0.422222222222222 14.1 14 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000408679751780754 0.00480620898168605 1.4341342724679 0.421875 14.1 14 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00185263735347436 0.0162734750246544 1.42776034236805 0.42 14.1 14 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.000123798286601748 0.00191214478585751 1.42001480705683 0.417721518987342 14.1 14 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0299377386241004 0.121371515846424 1.41642891107941 0.416666666666667 14.1 14 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.114395133108621 0.316018215993154 1.41642891107941 0.416666666666667 14.1 14 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.114395133108621 0.316018215993154 1.41642891107941 0.416666666666667 14.1 14 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.114395133108621 0.316018215993154 1.41642891107941 0.416666666666667 14.1 14 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.114395133108621 0.316018215993154 1.41642891107941 0.416666666666667 14.1 14 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.114395133108621 0.316018215993154 1.41642891107941 0.416666666666667 14.1 14 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.114395133108621 0.316018215993154 1.41642891107941 0.416666666666667 14.1 14 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.114395133108621 0.316018215993154 1.41642891107941 0.416666666666667 14.1 14 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000549007709173383 0.00587396970040394 1.41207066827609 0.415384615384615 14.1 14 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.00569959157207584 0.0375486981808515 1.40951950175707 0.414634146341463 14.1 14 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.00569959157207584 0.0375486981808515 1.40951950175707 0.414634146341463 14.1 14 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.00116400034503351 0.0111917060201533 1.40666043583059 0.413793103448276 14.1 14 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.00116400034503351 0.0111917060201533 1.40666043583059 0.413793103448276 14.1 14 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00375499986584994 0.0280223153111178 1.40411213793959 0.41304347826087 14.1 14 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00375499986584994 0.0280223153111178 1.40411213793959 0.41304347826087 14.1 14 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 0.00011088219728943 0.00180918334657189 1.3997650415373 0.411764705882353 14.1 14 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.012463043116402 0.0661750386367167 1.3997650415373 0.411764705882353 14.1 14 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0696575002853224 0.226977736625949 1.3997650415373 0.411764705882353 14.1 14 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00813435554668035 0.0488404554553845 1.3946376970628 0.41025641025641 14.1 14 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000155669789766474 0.00221518110837693 1.3925373390853 0.409638554216867 14.1 14 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0435865418957205 0.159443828065836 1.39067565815069 0.409090909090909 14.1 14 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.000487311294688665 0.00525336342683311 1.38849932691728 0.408450704225352 14.1 14 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0277386417071865 0.113100536244488 1.38495271305542 0.407407407407407 14.1 14 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0277386417071865 0.113100536244488 1.38495271305542 0.407407407407407 14.1 14 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0277386417071865 0.113100536244488 1.38495271305542 0.407407407407407 14.1 14 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0277386417071865 0.113100536244488 1.38495271305542 0.407407407407407 14.1 14 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0277386417071865 0.113100536244488 1.38495271305542 0.407407407407407 14.1 14 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0277386417071865 0.113100536244488 1.38495271305542 0.407407407407407 14.1 14 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.000146424526343522 0.00214407790630157 1.38348870384501 0.406976744186047 14.1 14 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0115966104554416 0.0625074874170202 1.3781470486178 0.405405405405405 14.1 14 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.000204881171330965 0.00265041733458149 1.37595951362 0.404761904761905 14.1 14 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.000204881171330965 0.00265041733458149 1.37595951362 0.404761904761905 14.1 14 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00757915681020418 0.0456997463598329 1.37595951362 0.404761904761905 14.1 14 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 5.81941779831757e-06 0.000196748247316893 1.37031262095124 0.403100775193798 14.1 14 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.6565568936926e-06 9.45070114931142e-05 1.36955428524513 0.402877697841727 14.1 14 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.63494319036345e-05 0.000604761961272127 1.36584216425515 0.401785714285714 14.1 14 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.000896058996937036 0.00904320533788228 1.35977175463623 0.4 14.1 14 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00305688640815907 0.0237702150754664 1.35977175463623 0.4 14.1 14 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00462866354051392 0.0315850717455622 1.35977175463623 0.4 14.1 14 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00703589224828307 0.0429063664348918 1.35977175463623 0.4 14.1 14 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0399883081031775 0.147800941378757 1.35977175463623 0.4 14.1 14 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0399883081031775 0.147800941378757 1.35977175463623 0.4 14.1 14 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0399883081031775 0.147800941378757 1.35977175463623 0.4 14.1 14 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0634669993098759 0.212003615065618 1.35977175463623 0.4 14.1 14 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0634669993098759 0.212003615065618 1.35977175463623 0.4 14.1 14 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.102986154140695 0.294761331686536 1.35977175463623 0.4 14.1 14 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.102986154140695 0.294761331686536 1.35977175463623 0.4 14.1 14 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.102986154140695 0.294761331686536 1.35977175463623 0.4 14.1 14 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.102986154140695 0.294761331686536 1.35977175463623 0.4 14.1 14 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.102986154140695 0.294761331686536 1.35977175463623 0.4 14.1 14 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.102986154140695 0.294761331686536 1.35977175463623 0.4 14.1 14 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.102986154140695 0.294761331686536 1.35977175463623 0.4 14.1 14 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.102986154140695 0.294761331686536 1.35977175463623 0.4 14.1 14 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.42320306195169e-07 6.2920601661144e-06 1.35605653126291 0.398907103825137 14.1 14 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 7.08030194432359e-06 0.000214367439718563 1.35465983074662 0.398496240601504 14.1 14 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.73373483664746e-07 3.18669350578188e-05 1.34733481785602 0.396341463414634 14.1 14 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.73889582475174e-07 1.40011809437414e-05 1.34440710204147 0.395480225988701 14.1 14 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00992590580689902 0.0564982558528692 1.34396045516372 0.395348837209302 14.1 14 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.015210742974642 0.0741263262086149 1.3418800210226 0.394736842105263 14.1 14 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0234693085318247 0.0999904971281033 1.33916915229326 0.393939393939394 14.1 14 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.00262881184056544 0.0213274202663335 1.3374804143963 0.39344262295082 14.1 14 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.00396928844523223 0.0292657899355723 1.33549011616059 0.392857142857143 14.1 14 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0365378476540146 0.138648952564434 1.33549011616059 0.392857142857143 14.1 14 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.00161639968990508 0.0146899572577218 1.33021149910066 0.391304347826087 14.1 14 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 3.51082745047442e-08 2.49795373101255e-06 1.32886785112177 0.390909090909091 14.1 14 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.00243068869999786 0.0203138420670895 1.32790210413695 0.390625 14.1 14 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.000186154351532703 0.00250830785195307 1.32577746077033 0.39 14.1 14 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.0214876473269404 0.0961274806086379 1.32200031700745 0.388888888888889 14.1 14 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0923967873868674 0.271094079281469 1.32200031700745 0.388888888888889 14.1 14 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0923967873868674 0.271094079281469 1.32200031700745 0.388888888888889 14.1 14 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00840841880079764 0.0500635144499374 1.31814608867798 0.387755102040816 14.1 14 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.00337759280462272 0.0258404008654738 1.31590814964797 0.387096774193548 14.1 14 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0128145952908852 0.0672884468595188 1.31341589936454 0.386363636363636 14.1 14 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.0128145952908852 0.0672884468595188 1.31341589936454 0.386363636363636 14.1 14 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 7.20105105230031e-08 4.76309564926183e-06 1.31099070514256 0.385650224215247 14.1 14 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000147659616878113 0.00214407790630157 1.30987187373215 0.385321100917431 14.1 14 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.152560745349848 0.376899202487559 1.30747284099638 0.384615384615385 14.1 14 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.152560745349848 0.376899202487559 1.30747284099638 0.384615384615385 14.1 14 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.152560745349848 0.376899202487559 1.30747284099638 0.384615384615385 14.1 14 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.152560745349848 0.376899202487559 1.30747284099638 0.384615384615385 14.1 14 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.41484383371526e-10 1.83029343216074e-08 1.30346218810989 0.383435582822086 14.1 14 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.00468338027991119 0.0315850717455622 1.30311459819306 0.383333333333333 14.1 14 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.00468338027991119 0.0315850717455622 1.30311459819306 0.383333333333333 14.1 14 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00468338027991119 0.0315850717455622 1.30311459819306 0.383333333333333 14.1 14 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.00468338027991119 0.0315850717455622 1.30311459819306 0.383333333333333 14.1 14 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.00468338027991119 0.0315850717455622 1.30311459819306 0.383333333333333 14.1 14 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.00468338027991119 0.0315850717455622 1.30311459819306 0.383333333333333 14.1 14 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.00468338027991119 0.0315850717455622 1.30311459819306 0.383333333333333 14.1 14 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.000186845138655675 0.00250830785195307 1.29796394760731 0.381818181818182 14.1 14 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.000186845138655675 0.00250830785195307 1.29796394760731 0.381818181818182 14.1 14 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.00175223236759533 0.0154871221061376 1.29715068698851 0.381578947368421 14.1 14 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00175223236759533 0.0154871221061376 1.29715068698851 0.381578947368421 14.1 14 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0179121716907778 0.0839493913377484 1.29502071870118 0.380952380952381 14.1 14 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0827950317631939 0.25375285730515 1.29502071870118 0.380952380952381 14.1 14 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0827950317631939 0.25375285730515 1.29502071870118 0.380952380952381 14.1 14 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.00262495962122426 0.0213274202663335 1.29274075264712 0.380281690140845 14.1 14 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00647873162591769 0.0402586685750257 1.2894387328447 0.379310344827586 14.1 14 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00647873162591769 0.0402586685750257 1.2894387328447 0.379310344827586 14.1 14 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00647873162591769 0.0402586685750257 1.2894387328447 0.379310344827586 14.1 14 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0471161393756319 0.171473826934845 1.2894387328447 0.379310344827586 14.1 14 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.0163230935667508 0.0784721694104269 1.28422887937867 0.377777777777778 14.1 14 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.000134505254573469 0.00201474712903206 1.28175206379645 0.377049180327869 14.1 14 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.00360896334405376 0.0273167810563218 1.28094440654138 0.376811594202899 14.1 14 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0148620593470671 0.0741263262086149 1.27478601997147 0.375 14.1 14 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0148620593470671 0.0741263262086149 1.27478601997147 0.375 14.1 14 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.0741748595460307 0.240434681398637 1.27478601997147 0.375 14.1 14 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.134407136390777 0.344167499488635 1.27478601997147 0.375 14.1 14 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.134407136390777 0.344167499488635 1.27478601997147 0.375 14.1 14 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.134407136390777 0.344167499488635 1.27478601997147 0.375 14.1 14 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.134407136390777 0.344167499488635 1.27478601997147 0.375 14.1 14 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.134407136390777 0.344167499488635 1.27478601997147 0.375 14.1 14 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.134407136390777 0.344167499488635 1.27478601997147 0.375 14.1 14 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.000435800688732591 0.00496115504053182 1.2708147239591 0.373831775700935 14.1 14 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 7.3638864570457e-08 4.76309564926183e-06 1.26824865576649 0.373076923076923 14.1 14 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0226447736960394 0.0987237251060199 1.26490395780115 0.372093023255814 14.1 14 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.00276280434981504 0.021963522847971 1.26389041296317 0.371794871794872 14.1 14 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0384207049935024 0.145020326805713 1.26264520073365 0.371428571428571 14.1 14 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00252481524993399 0.0207677000037923 1.25904792095948 0.37037037037037 14.1 14 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.066469544704152 0.219457452700715 1.25904792095948 0.37037037037037 14.1 14 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.066469544704152 0.219457452700715 1.25904792095948 0.37037037037037 14.1 14 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.78421244050784e-06 0.000260415297975889 1.25631086026174 0.369565217391304 14.1 14 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.118755608862478 0.321272303063319 1.25242135295443 0.368421052631579 14.1 14 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.118755608862478 0.321272303063319 1.25242135295443 0.368421052631579 14.1 14 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.118755608862478 0.321272303063319 1.25242135295443 0.368421052631579 14.1 14 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.118755608862478 0.321272303063319 1.25242135295443 0.368421052631579 14.1 14 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.118755608862478 0.321272303063319 1.25242135295443 0.368421052631579 14.1 14 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.118755608862478 0.321272303063319 1.25242135295443 0.368421052631579 14.1 14 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0186093345029656 0.0854228483797421 1.24876997874756 0.36734693877551 14.1 14 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000670291744847862 0.00700921601265115 1.24749702260205 0.36697247706422 14.1 14 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.84736860745876e-21 1.31440276420691e-18 1.24594470730243 0.366515837104072 14.1 14 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0313064227885694 0.124438658179146 1.24369367802095 0.365853658536585 14.1 14 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0313064227885694 0.124438658179146 1.24369367802095 0.365853658536585 14.1 14 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0313064227885694 0.124438658179146 1.24369367802095 0.365853658536585 14.1 14 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0313064227885694 0.124438658179146 1.24369367802095 0.365853658536585 14.1 14 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0313064227885694 0.124438658179146 1.24369367802095 0.365853658536585 14.1 14 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0313064227885694 0.124438658179146 1.24369367802095 0.365853658536585 14.1 14 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.48374369921053e-07 6.2920601661144e-06 1.23950313373881 0.364620938628159 14.1 14 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.053461907666673 0.183316372553435 1.23615614057839 0.363636363636364 14.1 14 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.105199883116036 0.299398867348239 1.23615614057839 0.363636363636364 14.1 14 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.105199883116036 0.299398867348239 1.23615614057839 0.363636363636364 14.1 14 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.000390076855961724 0.00466453248767675 1.23128938411942 0.362204724409449 14.1 14 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 6.57946770371146e-06 0.000203534403095248 1.23026968276612 0.361904761904762 14.1 14 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.57946770371146e-06 0.000203534403095248 1.23026968276612 0.361904761904762 14.1 14 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.0255176120738068 0.108070124943533 1.2295808419583 0.361702127659574 14.1 14 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0479915636746027 0.173770979921017 1.22757172293549 0.361111111111111 14.1 14 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0479915636746027 0.173770979921017 1.22757172293549 0.361111111111111 14.1 14 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00350261957908222 0.0266536238557968 1.22537570911986 0.36046511627907 14.1 14 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.023044248477555 0.099369592677457 1.22379457917261 0.36 14.1 14 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.093404794732636 0.271922247511571 1.22379457917261 0.36 14.1 14 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.093404794732636 0.271922247511571 1.22379457917261 0.36 14.1 14 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.093404794732636 0.271922247511571 1.22379457917261 0.36 14.1 14 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000434411629263546 0.00496115504053182 1.21964260434929 0.358778625954198 14.1 14 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000434411629263546 0.00496115504053182 1.21964260434929 0.358778625954198 14.1 14 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.0051835036583303 0.0347930457820944 1.21707965692749 0.358024691358025 14.1 14 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0830982652875614 0.25375285730515 1.21408192378235 0.357142857142857 14.1 14 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0830982652875614 0.25375285730515 1.21408192378235 0.357142857142857 14.1 14 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.0830982652875614 0.25375285730515 1.21408192378235 0.357142857142857 14.1 14 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0830982652875614 0.25375285730515 1.21408192378235 0.357142857142857 14.1 14 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.195161436355251 0.450715171887325 1.21408192378235 0.357142857142857 14.1 14 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.195161436355251 0.450715171887325 1.21408192378235 0.357142857142857 14.1 14 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.195161436355251 0.450715171887325 1.21408192378235 0.357142857142857 14.1 14 1 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.195161436355251 0.450715171887325 1.21408192378235 0.357142857142857 14.1 14 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.195161436355251 0.450715171887325 1.21408192378235 0.357142857142857 14.1 14 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.195161436355251 0.450715171887325 1.21408192378235 0.357142857142857 14.1 14 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0348490115650448 0.134590320577835 1.2086860041211 0.355555555555556 14.1 14 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00630804404493773 0.0402586685750257 1.20223722208691 0.353658536585366 14.1 14 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.0125628633463472 0.0664570800812344 1.19979860703197 0.352941176470588 14.1 14 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0661051058856684 0.219271714860854 1.19979860703197 0.352941176470588 14.1 14 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0661051058856684 0.219271714860854 1.19979860703197 0.352941176470588 14.1 14 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.169725119721026 0.410746335651395 1.19979860703197 0.352941176470588 14.1 14 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0590866764958674 0.198771490906901 1.1943941088021 0.351351351351351 14.1 14 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0528782139812008 0.183306300634636 1.1898002853067 0.35 14.1 14 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.0528782139812008 0.183306300634636 1.1898002853067 0.35 14.1 14 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.148526398621571 0.370145473272321 1.1898002853067 0.35 14.1 14 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.148526398621571 0.370145473272321 1.1898002853067 0.35 14.1 14 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.148526398621571 0.370145473272321 1.1898002853067 0.35 14.1 14 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.148526398621571 0.370145473272321 1.1898002853067 0.35 14.1 14 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.000396740778004366 0.00470468439250178 1.18431733468317 0.348387096774194 14.1 14 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 0.0152001425502831 0.0741263262086149 1.18241022142281 0.347826086956522 14.1 14 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0424853272668831 0.155816032733955 1.18241022142281 0.347826086956522 14.1 14 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.0424853272668831 0.155816032733955 1.18241022142281 0.347826086956522 14.1 14 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00162074721676902 0.0146899572577218 1.17883438405964 0.346774193548387 14.1 14 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.115258927688297 0.316018215993154 1.17672555689674 0.346153846153846 14.1 14 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.115258927688297 0.316018215993154 1.17672555689674 0.346153846153846 14.1 14 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.115258927688297 0.316018215993154 1.17672555689674 0.346153846153846 14.1 14 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.115258927688297 0.316018215993154 1.17672555689674 0.346153846153846 14.1 14 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.115258927688297 0.316018215993154 1.17672555689674 0.346153846153846 14.1 14 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.115258927688297 0.316018215993154 1.17672555689674 0.346153846153846 14.1 14 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000106121347844415 0.00177659621156004 1.17340709790944 0.345177664974619 14.1 14 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.0109532744494087 0.0597184273621019 1.15980532013091 0.341176470588235 14.1 14 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.0109532744494087 0.0597184273621019 1.15980532013091 0.341176470588235 14.1 14 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 0.0021734989065559 0.0185202930780182 1.14123700835541 0.335714285714286 14.1 14 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 0.00147292144351789 0.0136101767151036 1.14059801786921 0.335526315789474 14.1 14 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.00121348929075747 0.0115119684049859 1.14031492081836 0.335443037974684 14.1 14 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.000278067552521776 0.00347096602840778 1.13314312886353 0.333333333333333 14.1 14 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.0258021729852427 0.108951015305639 1.13314312886353 0.333333333333333 14.1 14 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.0547453176267182 0.185482349959095 1.13314312886353 0.333333333333333 14.1 14 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.0611837966845999 0.205340902552325 1.13314312886353 0.333333333333333 14.1 14 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.109110041541994 0.309290018155892 1.13314312886353 0.333333333333333 14.1 14 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.109110041541994 0.309290018155892 1.13314312886353 0.333333333333333 14.1 14 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.13965361918037 0.35327619139614 1.13314312886353 0.333333333333333 14.1 14 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.181392082050759 0.428772313551878 1.13314312886353 0.333333333333333 14.1 14 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.208389285888105 0.468464382020179 1.13314312886353 0.333333333333333 14.1 14 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.208389285888105 0.468464382020179 1.13314312886353 0.333333333333333 14.1 14 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.208389285888105 0.468464382020179 1.13314312886353 0.333333333333333 14.1 14 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.208389285888105 0.468464382020179 1.13314312886353 0.333333333333333 14.1 14 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.208389285888105 0.468464382020179 1.13314312886353 0.333333333333333 14.1 14 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.241249077462529 0.51085928159104 1.13314312886353 0.333333333333333 14.1 14 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.241249077462529 0.51085928159104 1.13314312886353 0.333333333333333 14.1 14 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.241249077462529 0.51085928159104 1.13314312886353 0.333333333333333 14.1 14 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.00684955014744803 0.0420125424992179 1.13314312886353 0.333333333333333 14.1 14 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 7.20945882419688e-09 6.03474112166598e-07 1.12520517349496 0.330998248686515 14.1 14 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 0.00442552503630458 0.0313383437604614 1.12442664325689 0.330769230769231 14.1 14 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00595527411430667 0.039052327486905 1.12377830961672 0.330578512396694 14.1 14 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.0303727319831483 0.122785220488693 1.11762062024896 0.328767123287671 14.1 14 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0337579912753777 0.131250332199078 1.11695536987976 0.328571428571429 14.1 14 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0375457421604393 0.142094657165705 1.11623054485064 0.328358208955224 14.1 14 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 9.735313269976e-05 0.00164920842656855 1.11231329193589 0.327205882352941 14.1 14 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0114616843299292 0.0620151209182102 1.11196288346421 0.327102803738318 14.1 14 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.0171941816449074 0.082105102284239 1.10928748404535 0.326315789473684 14.1 14 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00446838740109028 0.0314777983750073 1.10903370058984 0.326241134751773 14.1 14 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0908892144994262 0.271024556855116 1.106790963076 0.325581395348837 14.1 14 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.34094405898196e-09 5.63947712245708e-07 1.10494672130238 0.325038880248834 14.1 14 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.0288030144692112 0.117104827399107 1.10481455064194 0.325 14.1 14 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.57198873765571e-07 6.39125706766879e-06 1.1013132656932 0.323970037453184 14.1 14 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 0.00847796869408943 0.0502672893820386 1.09745358149775 0.322834645669291 14.1 14 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.00936232643217846 0.0546007807909424 1.09659012470664 0.32258064516129 14.1 14 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.00936232643217846 0.0546007807909424 1.09659012470664 0.32258064516129 14.1 14 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.00936232643217846 0.0546007807909424 1.09659012470664 0.32258064516129 14.1 14 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.146685117351263 0.368135664886856 1.09659012470664 0.32258064516129 14.1 14 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 0.00659806831891491 0.0408219618165909 1.09267373140412 0.321428571428571 14.1 14 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.166442997340121 0.409064568592388 1.09267373140412 0.321428571428571 14.1 14 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 0.00204153014649465 0.0176187662156678 1.0907260063927 0.320855614973262 14.1 14 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 0.00423086116125078 0.0307632775987967 1.09038301079321 0.320754716981132 14.1 14 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 0.00535705242697664 0.0357891342891444 1.08262082375496 0.318471337579618 14.1 14 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 0.00107903669599809 0.0105169124548307 1.08232953564095 0.318385650224215 14.1 14 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.21694844155363 0.485405082281157 1.0816366230061 0.318181818181818 14.1 14 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.21694844155363 0.485405082281157 1.0816366230061 0.318181818181818 14.1 14 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.119778000486124 0.323423329585872 1.07786785428482 0.317073170731707 14.1 14 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 0.0096144383889278 0.0555757175790134 1.07607836697831 0.316546762589928 14.1 14 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.134866750144693 0.344167499488635 1.07350401681808 0.315789473684211 14.1 14 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.249758675284549 0.528093008811163 1.07350401681808 0.315789473684211 14.1 14 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.0184982049841884 0.0851875265129452 1.07350401681808 0.315789473684211 14.1 14 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0063672960885028 0.0402586685750257 1.07019073281555 0.314814814814815 14.1 14 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.0226011348209854 0.0987237251060199 1.07019073281555 0.314814814814815 14.1 14 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 0.0173599090108265 0.0823438350746869 1.06758939413589 0.31404958677686 14.1 14 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 0.0173599090108265 0.0823438350746869 1.06758939413589 0.31404958677686 14.1 14 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.0656961672873414 0.218935939226901 1.06549279281197 0.313432835820896 14.1 14 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.172196232700222 0.411880677189933 1.06232168330956 0.3125 14.1 14 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.172196232700222 0.411880677189933 1.06232168330956 0.3125 14.1 14 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.289813596131507 0.564165180978296 1.06232168330956 0.3125 14.1 14 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.289813596131507 0.564165180978296 1.06232168330956 0.3125 14.1 14 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.289813596131507 0.564165180978296 1.06232168330956 0.3125 14.1 14 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.289813596131507 0.564165180978296 1.06232168330956 0.3125 14.1 14 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00907857610371034 0.0536050364961818 1.05572341198465 0.31055900621118 14.1 14 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.195426044310948 0.450715171887325 1.05499532687294 0.310344827586207 14.1 14 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.195426044310948 0.450715171887325 1.05499532687294 0.310344827586207 14.1 14 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.195426044310948 0.450715171887325 1.05499532687294 0.310344827586207 14.1 14 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.0349422908043145 0.134590320577835 1.05382310984308 0.31 14.1 14 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0109978148036276 0.0597324063571074 1.05272651971837 0.309677419354839 14.1 14 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 0.0225373472480286 0.0987237251060199 1.05023021699547 0.308943089430894 14.1 14 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.64819115546967e-14 6.28062669038889e-12 1.04901694434493 0.308586184635249 14.1 14 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0839449928430235 0.254489065417554 1.0459782727971 0.307692307692308 14.1 14 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.11359253659026 0.316018215993154 1.0459782727971 0.307692307692308 14.1 14 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.222610771411299 0.487859785239047 1.0459782727971 0.307692307692308 14.1 14 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.00634089485287525 0.0402586685750257 1.04461632192107 0.307291666666667 14.1 14 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.0524527866447437 0.182941949498702 1.04300674361302 0.306818181818182 14.1 14 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 0.0697043365464087 0.226977736625949 1.04249167855445 0.306666666666667 14.1 14 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 0.0697043365464087 0.226977736625949 1.04249167855445 0.306666666666667 14.1 14 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 0.0697043365464087 0.226977736625949 1.04249167855445 0.306666666666667 14.1 14 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 0.0697043365464087 0.226977736625949 1.04249167855445 0.306666666666667 14.1 14 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 0.0697043365464087 0.226977736625949 1.04249167855445 0.306666666666667 14.1 14 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.058112205612381 0.196422015644699 1.03982545942771 0.305882352941176 14.1 14 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.00244108713525811 0.0203138420670895 1.03871453479157 0.305555555555556 14.1 14 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.00244108713525811 0.0203138420670895 1.03871453479157 0.305555555555556 14.1 14 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.00244108713525811 0.0203138420670895 1.03871453479157 0.305555555555556 14.1 14 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0774289600265055 0.246490850375207 1.03871453479157 0.305555555555556 14.1 14 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.176556278587484 0.418035914192994 1.03871453479157 0.305555555555556 14.1 14 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.14250532951637 0.358277533395397 1.03460894374496 0.304347826086957 14.1 14 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.254728515623074 0.536211061733187 1.03460894374496 0.304347826086957 14.1 14 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.254728515623074 0.536211061733187 1.03460894374496 0.304347826086957 14.1 14 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0714177365967586 0.232026116842894 1.03273804149587 0.30379746835443 14.1 14 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.199625011464669 0.454506226102758 1.03013011714866 0.303030303030303 14.1 14 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.199625011464669 0.454506226102758 1.03013011714866 0.303030303030303 14.1 14 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 0.000129261583128153 0.00195680034884427 1.02897526275724 0.302690582959641 14.1 14 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.079226183031752 0.251649237620944 1.02877468278399 0.302631578947368 14.1 14 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0177956126342452 0.0838515125116919 1.02624283368772 0.30188679245283 14.1 14 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0177956126342452 0.0838515125116919 1.02624283368772 0.30188679245283 14.1 14 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 0.0130406355674099 0.0682236191633245 1.02168642766384 0.300546448087432 14.1 14 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 0.0199413262667181 0.0912427886737614 1.01982881597718 0.3 14.1 14 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.293143936711539 0.565790628272999 1.01982881597718 0.3 14.1 14 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.293143936711539 0.565790628272999 1.01982881597718 0.3 14.1 14 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 0.000702882450194187 0.00714429804733092 1.01801093929985 0.299465240641711 14.1 14 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.0743485730170061 0.240450044098181 1.01592142587765 0.298850574712644 14.1 14 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 0.091039872225401 0.271024556855116 1.00723833676758 0.296296296296296 14.1 14 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 0.091039872225401 0.271024556855116 1.00723833676758 0.296296296296296 14.1 14 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.0835306769795677 0.254489065417554 1.00437686421995 0.295454545454545 14.1 14 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.0767123746576393 0.24475719537628 1.00193708236354 0.294736842105263 14.1 14 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.0767123746576393 0.24475719537628 1.00193708236354 0.294736842105263 14.1 14 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.0923206466435538 0.271094079281469 0.999832172526643 0.294117647058824 14.1 14 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.0923206466435538 0.271094079281469 0.999832172526643 0.294117647058824 14.1 14 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.0923206466435538 0.271094079281469 0.999832172526643 0.294117647058824 14.1 14 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.0923206466435538 0.271094079281469 0.999832172526643 0.294117647058824 14.1 14 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.0923206466435538 0.271094079281469 0.999832172526643 0.294117647058824 14.1 14 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.228769758131371 0.488065016223299 0.999832172526643 0.294117647058824 14.1 14 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.228769758131371 0.488065016223299 0.999832172526643 0.294117647058824 14.1 14 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.228769758131371 0.488065016223299 0.999832172526643 0.294117647058824 14.1 14 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.228769758131371 0.488065016223299 0.999832172526643 0.294117647058824 14.1 14 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.339850461302541 0.617126224861655 0.999832172526643 0.294117647058824 14.1 14 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.339850461302541 0.617126224861655 0.999832172526643 0.294117647058824 14.1 14 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.339850461302541 0.617126224861655 0.999832172526643 0.294117647058824 14.1 14 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.339850461302541 0.617126224861655 0.999832172526643 0.294117647058824 14.1 14 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.339850461302541 0.617126224861655 0.999832172526643 0.294117647058824 14.1 14 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.339850461302541 0.617126224861655 0.999832172526643 0.294117647058824 14.1 14 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.03885232232727 0.14512336665305 0.99843380585178 0.293706293706294 14.1 14 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.093443414640308 0.271922247511571 0.993091730914103 0.292134831460674 14.1 14 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.184187287718785 0.433838837636667 0.991500237755587 0.291666666666667 14.1 14 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.29422703086579 0.565790628272999 0.991500237755587 0.291666666666667 14.1 14 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.29422703086579 0.565790628272999 0.991500237755587 0.291666666666667 14.1 14 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.29422703086579 0.565790628272999 0.991500237755587 0.291666666666667 14.1 14 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 0.112853728883557 0.316018215993154 0.989707289766879 0.291139240506329 14.1 14 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 0.112853728883557 0.316018215993154 0.989707289766879 0.291139240506329 14.1 14 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.112853728883557 0.316018215993154 0.989707289766879 0.291139240506329 14.1 14 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.166393932697555 0.409064568592388 0.988924912462716 0.290909090909091 14.1 14 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.166393932697555 0.409064568592388 0.988924912462716 0.290909090909091 14.1 14 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.103156109051226 0.294761331686536 0.988206217032147 0.290697674418605 14.1 14 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.258947936427121 0.536990820145385 0.986931112235976 0.290322580645161 14.1 14 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.258947936427121 0.536990820145385 0.986931112235976 0.290322580645161 14.1 14 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 0.0444419144491187 0.162156010925887 0.980604630747284 0.288461538461538 14.1 14 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.185512880260246 0.434185573372254 0.980604630747284 0.288461538461538 14.1 14 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.041007064743214 0.151173712770968 0.980203565458635 0.288343558282209 14.1 14 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.0328131274043281 0.129703000823219 0.973794876367095 0.286458333333333 14.1 14 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.207004222221642 0.468464382020179 0.971265539025881 0.285714285714286 14.1 14 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.230978712534187 0.491358379690617 0.971265539025881 0.285714285714286 14.1 14 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.259399725904099 0.536990820145385 0.971265539025881 0.285714285714286 14.1 14 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.259399725904099 0.536990820145385 0.971265539025881 0.285714285714286 14.1 14 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.259399725904099 0.536990820145385 0.971265539025881 0.285714285714286 14.1 14 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.259399725904099 0.536990820145385 0.971265539025881 0.285714285714286 14.1 14 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.259399725904099 0.536990820145385 0.971265539025881 0.285714285714286 14.1 14 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.29397893919695 0.565790628272999 0.971265539025881 0.285714285714286 14.1 14 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.337844678575851 0.617126224861655 0.971265539025881 0.285714285714286 14.1 14 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 7.47690203449354e-05 0.00132995394938554 0.970643730102049 0.285531370038412 14.1 14 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.139550060083006 0.35327619139614 0.965270072735598 0.283950617283951 14.1 14 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.207452134339523 0.468464382020179 0.962102656582241 0.283018867924528 14.1 14 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.140019516477458 0.35327619139614 0.959838885625577 0.282352941176471 14.1 14 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.140019516477458 0.35327619139614 0.959838885625577 0.282352941176471 14.1 14 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.140019516477458 0.35327619139614 0.959838885625577 0.282352941176471 14.1 14 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.25917790394474 0.536990820145385 0.958813416730678 0.282051282051282 14.1 14 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0760531086165607 0.243746787300374 0.957585742701573 0.28169014084507 14.1 14 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.292894255276777 0.565790628272999 0.956089514978602 0.28125 14.1 14 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.231004044984555 0.491358379690617 0.951840228245364 0.28 14.1 14 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.334923318193152 0.617126224861655 0.951840228245364 0.28 14.1 14 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.140539775356689 0.353961239526669 0.950378108079088 0.279569892473118 14.1 14 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0906874701910957 0.271024556855116 0.946983900550234 0.278571428571429 14.1 14 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 7.77364428998042e-05 0.00134325247569035 0.945987356829012 0.278278278278278 14.1 14 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.291262590256644 0.565790628272999 0.944285940719607 0.277777777777778 14.1 14 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.390412451846554 0.677729042839907 0.944285940719607 0.277777777777778 14.1 14 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.390412451846554 0.677729042839907 0.944285940719607 0.277777777777778 14.1 14 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.390412451846554 0.677729042839907 0.944285940719607 0.277777777777778 14.1 14 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.390412451846554 0.677729042839907 0.944285940719607 0.277777777777778 14.1 14 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.390412451846554 0.677729042839907 0.944285940719607 0.277777777777778 14.1 14 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.327870221706318 0.612282579380696 0.927117105433796 0.272727272727273 14.1 14 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.383180767459183 0.677729042839907 0.927117105433796 0.272727272727273 14.1 14 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.184397648915048 0.433838837636667 0.923757985486572 0.271739130434783 14.1 14 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.115560950394319 0.316236985405991 0.921135704753578 0.270967741935484 14.1 14 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.284596026770327 0.557056597103405 0.920678792201617 0.270833333333333 14.1 14 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0590806931419027 0.198771490906901 0.919845598724511 0.270588235294118 14.1 14 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.151141646642428 0.376004481070236 0.919517784897453 0.270491803278689 14.1 14 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.376301624902255 0.676962341638318 0.915230988697465 0.269230769230769 14.1 14 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.376301624902255 0.676962341638318 0.915230988697465 0.269230769230769 14.1 14 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.016692628513106 0.0799784861082485 0.913382037205147 0.268686868686869 14.1 14 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.369765587906613 0.666890280850583 0.906514503090823 0.266666666666667 14.1 14 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.218949742345626 0.487859785239047 0.906514503090823 0.266666666666667 14.1 14 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.316427817123802 0.598816608801715 0.906514503090823 0.266666666666667 14.1 14 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.172868024507255 0.411880677189933 0.899848955273978 0.264705882352941 14.1 14 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.268684092722076 0.536990820145385 0.897071643683627 0.263888888888889 14.1 14 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.440645943475842 0.719909191579018 0.894586680681733 0.263157894736842 14.1 14 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.185504605261353 0.434185573372254 0.893280714724533 0.262773722627737 14.1 14 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.185504605261353 0.434185573372254 0.893280714724533 0.262773722627737 14.1 14 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.351944227737696 0.637982975886294 0.890326744107058 0.261904761904762 14.1 14 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.428516856342515 0.702510929234331 0.886807666067109 0.260869565217391 14.1 14 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.250203513297655 0.528248663831696 0.883851640513552 0.26 14.1 14 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.417868159084794 0.68742935303776 0.881333544671633 0.259259259259259 14.1 14 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.280815607704961 0.553381903491754 0.879852311823445 0.258823529411765 14.1 14 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.280815607704961 0.553381903491754 0.879852311823445 0.258823529411765 14.1 14 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.408310857986435 0.677729042839907 0.877272099765312 0.258064516129032 14.1 14 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.408310857986435 0.677729042839907 0.877272099765312 0.258064516129032 14.1 14 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.408310857986435 0.677729042839907 0.877272099765312 0.258064516129032 14.1 14 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.271339573687821 0.541537466139928 0.876141594482109 0.257731958762887 14.1 14 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.209209918366503 0.469567371980337 0.869621470988289 0.255813953488372 14.1 14 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.294023459297051 0.565790628272999 0.867939417852915 0.25531914893617 14.1 14 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.18445010314138 0.433838837636667 0.860096591787979 0.253012048192771 14.1 14 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.473280131501424 0.752488968856455 0.849857346647646 0.25 14.1 14 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.473280131501424 0.752488968856455 0.849857346647646 0.25 14.1 14 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.473280131501424 0.752488968856455 0.849857346647646 0.25 14.1 14 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.473280131501424 0.752488968856455 0.849857346647646 0.25 14.1 14 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.32531449549294 0.608308182768007 0.849857346647646 0.25 14.1 14 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.32531449549294 0.608308182768007 0.849857346647646 0.25 14.1 14 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.425657185209531 0.698627652310453 0.849857346647646 0.25 14.1 14 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.489813279063943 0.77358967381575 0.849857346647646 0.25 14.1 14 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.489813279063943 0.77358967381575 0.849857346647646 0.25 14.1 14 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.489813279063943 0.77358967381575 0.849857346647646 0.25 14.1 14 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.446783058889654 0.729096666055021 0.849857346647646 0.25 14.1 14 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.360620777299105 0.652050020453146 0.840719095608424 0.247311827956989 14.1 14 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.397776848619249 0.677729042839907 0.837540573507825 0.246376811594203 14.1 14 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.420839880435885 0.691518648799382 0.834947568636284 0.245614035087719 14.1 14 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 0.202185703851976 0.459601048852016 0.829129118680631 0.24390243902439 14.1 14 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.363380564839723 0.656206273815896 0.829129118680631 0.24390243902439 14.1 14 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.484835166788323 0.769142076187049 0.82410409371893 0.242424242424242 14.1 14 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.359001272971361 0.649947597249677 0.822791826053772 0.24203821656051 14.1 14 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.516971756756669 0.795298172826746 0.81586305278174 0.24 14.1 14 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.516971756756669 0.795298172826746 0.81586305278174 0.24 14.1 14 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.516971756756669 0.795298172826746 0.81586305278174 0.24 14.1 14 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.516971756756669 0.795298172826746 0.81586305278174 0.24 14.1 14 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.480926678999632 0.763793152027318 0.812907027228183 0.239130434782609 14.1 14 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.440647158022013 0.719909191579018 0.811227467254571 0.238636363636364 14.1 14 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.506955592218142 0.788412904619034 0.80512801261356 0.236842105263158 14.1 14 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.488434611975878 0.77358967381575 0.803501491375957 0.236363636363636 14.1 14 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.439217094293145 0.719224309757359 0.80301481573006 0.236220472440945 14.1 14 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.52215479084833 0.796978656086683 0.799865738021314 0.235294117647059 14.1 14 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.512663510298193 0.79209573849547 0.795611133031839 0.234042553191489 14.1 14 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.539346764449386 0.796978656086683 0.79320019020447 0.233333333333333 14.1 14 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.539346764449386 0.796978656086683 0.79320019020447 0.233333333333333 14.1 14 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.500256258902157 0.778845357131039 0.787236278999925 0.231578947368421 14.1 14 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.541574606495971 0.799440523904322 0.784483704597827 0.230769230769231 14.1 14 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.525665290236555 0.796978656086683 0.777012431220705 0.228571428571429 14.1 14 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.58263367238038 0.842568816867155 0.772597587861497 0.227272727272727 14.1 14 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.58263367238038 0.842568816867155 0.772597587861497 0.227272727272727 14.1 14 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.574219588338747 0.832092132592706 0.763137209234621 0.224489795918367 14.1 14 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.585410456969547 0.845724954586462 0.758670936063135 0.223175965665236 14.1 14 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.587214744172816 0.847471177442107 0.755428752575686 0.222222222222222 14.1 14 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.588272577833111 0.848137667939733 0.755428752575686 0.222222222222222 14.1 14 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.599545549806764 0.855720478811459 0.755428752575686 0.222222222222222 14.1 14 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.607732865387021 0.866536941328388 0.746216206812567 0.219512195121951 14.1 14 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.627000705529355 0.875393911715448 0.741693684347037 0.218181818181818 14.1 14 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.625443899057565 0.875393911715448 0.739006388389258 0.217391304347826 14.1 14 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.638937706601073 0.875393911715448 0.728449154269411 0.214285714285714 14.1 14 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.637831272741133 0.875393911715448 0.728449154269411 0.214285714285714 14.1 14 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.649009541011805 0.875393911715448 0.721091082004063 0.212121212121212 14.1 14 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.649009541011805 0.875393911715448 0.721091082004063 0.212121212121212 14.1 14 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.649009541011805 0.875393911715448 0.721091082004063 0.212121212121212 14.1 14 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.665486995782865 0.895073719280734 0.708214455539705 0.208333333333333 14.1 14 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.665486995782865 0.895073719280734 0.708214455539705 0.208333333333333 14.1 14 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.689613939234448 0.925774184462848 0.697318848531402 0.205128205128205 14.1 14 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.689613939234448 0.925774184462848 0.697318848531402 0.205128205128205 14.1 14 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.702615805539414 0.929202872939207 0.679885877318117 0.2 14.1 14 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.702615805539414 0.929202872939207 0.679885877318117 0.2 14.1 14 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.718210411196664 0.939893890254535 0.679885877318117 0.2 14.1 14 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.74988346064448 0.961076880964447 0.679885877318117 0.2 14.1 14 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.777220682145819 0.991026013166219 0.67149222451172 0.197530864197531 14.1 14 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.744992846544457 0.959388977948201 0.663303294944504 0.195121951219512 14.1 14 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.738646851032278 0.954090128616095 0.657954074823984 0.193548387096774 14.1 14 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.736768902974276 0.953978297481706 0.653736420498189 0.192307692307692 14.1 14 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.910218820377511 1 0.643135289354976 0.189189189189189 14.1 14 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.76821129579045 0.980416747901175 0.643135289354975 0.189189189189189 14.1 14 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.794111628950554 0.99651713633407 0.637393009985735 0.1875 14.1 14 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.794111628950554 0.99651713633407 0.637393009985735 0.1875 14.1 14 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.767956028694165 0.980416747901175 0.629523960479738 0.185185185185185 14.1 14 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.792816160118939 0.99651713633407 0.626210676477213 0.184210526315789 14.1 14 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.999999818995703 1 0.621846839010473 0.182926829268293 14.1 14 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.796244019118737 0.996530553391349 0.607040961891176 0.178571428571429 14.1 14 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.796244019118737 0.996530553391349 0.607040961891176 0.178571428571429 14.1 14 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.888334673130614 1 0.591205110711406 0.173913043478261 14.1 14 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.821743769750753 1 0.586108514929411 0.172413793103448 14.1 14 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.821743769750753 1 0.586108514929411 0.172413793103448 14.1 14 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.821743769750753 1 0.586108514929411 0.172413793103448 14.1 14 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.854743817978751 1 0.580390383076441 0.170731707317073 14.1 14 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.844598557902108 1 0.566571564431764 0.166666666666667 14.1 14 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.883216144383436 1 0.566571564431764 0.166666666666667 14.1 14 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.844598557902108 1 0.566571564431764 0.166666666666667 14.1 14 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.844598557902108 1 0.566571564431764 0.166666666666667 14.1 14 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.980969918220257 1 0.559662155109426 0.164634146341463 14.1 14 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.933346589163433 1 0.559399772476932 0.164556962025316 14.1 14 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.957224016213958 1 0.555675957423461 0.163461538461538 14.1 14 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.923022171704433 1 0.54829506235332 0.161290322580645 14.1 14 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.99799287592561 1 0.533243825347543 0.156862745098039 14.1 14 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.883048885072835 1 0.531160841654779 0.15625 14.1 14 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.899009227063025 1 0.515065058574331 0.151515151515152 14.1 14 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.938071432832724 1 0.513121416843862 0.150943396226415 14.1 14 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.955559943614861 1 0.501555155398611 0.147540983606557 14.1 14 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.913041445275198 1 0.499916086263321 0.147058823529412 14.1 14 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.942282894185245 1 0.495750118877794 0.145833333333333 14.1 14 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.925328517623675 1 0.485632769512941 0.142857142857143 14.1 14 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.970323017795195 1 0.478044757489301 0.140625 14.1 14 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.972104726079705 1 0.448981239738379 0.132075471698113 14.1 14 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.971542208566304 1 0.433969708926458 0.127659574468085 14.1 14 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.989095042875086 1 0.430913584215708 0.126760563380282 14.1 14 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999992808352416 1 0.391639330252372 0.115207373271889 14.1 14 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.992068578944951 1 0.39009845419892 0.114754098360656 14.1 14 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999980754520525 1 0.383806543647324 0.112903225806452 14.1 14 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999999093083 1 0.376740885627307 0.110824742268041 14.1 14 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999941733104 1 0.364224577134706 0.107142857142857 14.1 14 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999995001268199 1 0.347668914537673 0.102272727272727 14.1 14 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.992959597981665 1 0.3468805496521 0.102040816326531 14.1 14 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.339657512178236 0.0999160369437447 14.1 14 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.999892649760629 1 0.309039035144599 0.0909090909090909 14.1 14 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.273552635991467 0.0804701627486438 14.1 14 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.99991141931097 1 0.258184510373968 0.0759493670886076 14.1 14 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999994639296985 1 0.251809584191895 0.0740740740740741 14.1 14 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999998166987896 1 0.188857188143921 0.0555555555555556 14.1 14 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0383806543647324 0.0112903225806452 14.1 14 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 7.01577151601165e-07 3.53155623443566e-06 1.30071210579858 1 15.3 15 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 7.01577151601165e-07 3.53155623443566e-06 1.30071210579858 1 15.3 15 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 1.61511834180815e-06 7.53545377178034e-06 1.30071210579858 1 15.3 15 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 3.71806163288342e-06 1.65855852777213e-05 1.30071210579858 1 15.3 15 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 8.55878555230986e-06 3.46984382932676e-05 1.30071210579858 1 15.3 15 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 8.55878555230986e-06 3.46984382932676e-05 1.30071210579858 1 15.3 15 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 1.97011252283722e-05 7.68074005478731e-05 1.30071210579858 1 15.3 15 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 1.97011252283722e-05 7.68074005478731e-05 1.30071210579858 1 15.3 15 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 4.53474892245001e-05 0.000163780398899654 1.30071210579858 1 15.3 15 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 4.53474892245001e-05 0.000163780398899654 1.30071210579858 1 15.3 15 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 4.53474892245001e-05 0.000163780398899654 1.30071210579858 1 15.3 15 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 4.53474892245001e-05 0.000163780398899654 1.30071210579858 1 15.3 15 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 4.53474892245001e-05 0.000163780398899654 1.30071210579858 1 15.3 15 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.000104375553282915 0.000354478311030043 1.30071210579858 1 15.3 15 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000104375553282915 0.000354478311030043 1.30071210579858 1 15.3 15 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000240230235089025 0.000759661387848182 1.30071210579858 1 15.3 15 3 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.000240230235089025 0.000759661387848182 1.30071210579858 1 15.3 15 3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.000240230235089025 0.000759661387848182 1.30071210579858 1 15.3 15 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000240230235089025 0.000759661387848182 1.30071210579858 1 15.3 15 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000240230235089025 0.000759661387848182 1.30071210579858 1 15.3 15 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.000552891451075209 0.00160564190791841 1.30071210579858 1 15.3 15 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.000552891451075209 0.00160564190791841 1.30071210579858 1 15.3 15 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000552891451075209 0.00160564190791841 1.30071210579858 1 15.3 15 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.000552891451075209 0.00160564190791841 1.30071210579858 1 15.3 15 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.000552891451075209 0.00160564190791841 1.30071210579858 1 15.3 15 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.000552891451075209 0.00160564190791841 1.30071210579858 1 15.3 15 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000552891451075209 0.00160564190791841 1.30071210579858 1 15.3 15 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.00127243444762616 0.00340352296799254 1.30071210579858 1 15.3 15 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00127243444762616 0.00340352296799254 1.30071210579858 1 15.3 15 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00127243444762616 0.00340352296799254 1.30071210579858 1 15.3 15 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00127243444762616 0.00340352296799254 1.30071210579858 1 15.3 15 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00127243444762616 0.00340352296799254 1.30071210579858 1 15.3 15 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00127243444762616 0.00340352296799254 1.30071210579858 1 15.3 15 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00292829143439657 0.00719703530997571 1.30071210579858 1 15.3 15 3 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00292829143439657 0.00719703530997571 1.30071210579858 1 15.3 15 3 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00292829143439657 0.00719703530997571 1.30071210579858 1 15.3 15 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00292829143439657 0.00719703530997571 1.30071210579858 1 15.3 15 3 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00292829143439657 0.00719703530997571 1.30071210579858 1 15.3 15 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00673870607720081 0.0147299212716694 1.30071210579858 1 15.3 15 3 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.015506795890948 0.0303106738362899 1.30071210579858 1 15.3 15 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.39669807475041e-12 7.27500158182539e-11 1.26458121397084 0.972222222222222 15.3 15 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.3449017545455e-08 1.0812402241346e-07 1.25068471711402 0.961538461538462 15.3 15 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 7.0790913915833e-07 3.54702360923347e-06 1.23877343409388 0.952380952380952 15.3 15 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.55496520383565e-06 7.3026913698288e-06 1.23567650050865 0.95 15.3 15 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 1.623177738512e-05 6.39828787230629e-05 1.22419962898689 0.941176470588235 15.3 15 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 1.623177738512e-05 6.39828787230629e-05 1.22419962898689 0.941176470588235 15.3 15 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 3.52622109990124e-05 0.00013239611148178 1.21941759918616 0.9375 15.3 15 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 3.52622109990124e-05 0.00013239611148178 1.21941759918616 0.9375 15.3 15 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 3.52622109990124e-05 0.00013239611148178 1.21941759918616 0.9375 15.3 15 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 7.63289204242802e-05 0.000266215818048409 1.213997965412 0.933333333333333 15.3 15 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 7.63289204242802e-05 0.000266215818048409 1.213997965412 0.933333333333333 15.3 15 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 7.63289204242802e-05 0.000266215818048409 1.213997965412 0.933333333333333 15.3 15 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 7.63289204242802e-05 0.000266215818048409 1.213997965412 0.933333333333333 15.3 15 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 7.63289204242802e-05 0.000266215818048409 1.213997965412 0.933333333333333 15.3 15 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 4.93860148930459e-08 3.24911266399497e-07 1.20780409824153 0.928571428571429 15.3 15 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.000164551541017183 0.000541631381930048 1.20780409824153 0.928571428571429 15.3 15 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000164551541017183 0.000541631381930048 1.20780409824153 0.928571428571429 15.3 15 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.000164551541017183 0.000541631381930048 1.20780409824153 0.928571428571429 15.3 15 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.000164551541017183 0.000541631381930048 1.20780409824153 0.928571428571429 15.3 15 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.000164551541017183 0.000541631381930048 1.20780409824153 0.928571428571429 15.3 15 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000164551541017183 0.000541631381930048 1.20780409824153 0.928571428571429 15.3 15 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 2.26180620217916e-07 1.21454725498149e-06 1.20065732842945 0.923076923076923 15.3 15 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 2.26180620217916e-07 1.21454725498149e-06 1.20065732842945 0.923076923076923 15.3 15 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 2.26180620217916e-07 1.21454725498149e-06 1.20065732842945 0.923076923076923 15.3 15 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000353103857178033 0.00109231910600944 1.20065732842945 0.923076923076923 15.3 15 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000353103857178033 0.00109231910600944 1.20065732842945 0.923076923076923 15.3 15 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000353103857178033 0.00109231910600944 1.20065732842945 0.923076923076923 15.3 15 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.000353103857178033 0.00109231910600944 1.20065732842945 0.923076923076923 15.3 15 3 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.000753684257925482 0.00213643963949793 1.19231943031536 0.916666666666667 15.3 15 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000753684257925482 0.00213643963949793 1.19231943031536 0.916666666666667 15.3 15 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.16732944600369e-06 1.00133435118937e-05 1.18760670529435 0.91304347826087 15.3 15 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00159877705315012 0.00412896505740949 1.18246555072598 0.909090909090909 15.3 15 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00159877705315012 0.00412896505740949 1.18246555072598 0.909090909090909 15.3 15 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00159877705315012 0.00412896505740949 1.18246555072598 0.909090909090909 15.3 15 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00159877705315012 0.00412896505740949 1.18246555072598 0.909090909090909 15.3 15 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00159877705315012 0.00412896505740949 1.18246555072598 0.909090909090909 15.3 15 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00159877705315012 0.00412896505740949 1.18246555072598 0.909090909090909 15.3 15 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 2.14978541006142e-10 2.54906117149846e-09 1.17683476238919 0.904761904761905 15.3 15 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 9.60199781827017e-06 3.88135085839297e-05 1.17683476238919 0.904761904761905 15.3 15 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.49045034473161e-10 4.84084154587355e-09 1.17381336376945 0.902439024390244 15.3 15 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.49045034473161e-10 4.84084154587355e-09 1.17381336376945 0.902439024390244 15.3 15 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.22586367569312e-12 5.46476667918013e-11 1.17319131111244 0.901960784313726 15.3 15 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.22586367569312e-12 5.46476667918013e-11 1.17319131111244 0.901960784313726 15.3 15 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00336684239495087 0.00803861867116625 1.17064089521872 0.9 15.3 15 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00336684239495087 0.00803861867116625 1.17064089521872 0.9 15.3 15 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00336684239495087 0.00803861867116625 1.17064089521872 0.9 15.3 15 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00336684239495087 0.00803861867116625 1.17064089521872 0.9 15.3 15 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.39575387544282e-11 2.13565351048939e-10 1.16798638071709 0.897959183673469 15.3 15 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 4.17901705406969e-05 0.000152872526168154 1.1637950420303 0.894736842105263 15.3 15 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 4.17901705406969e-05 0.000152872526168154 1.1637950420303 0.894736842105263 15.3 15 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 5.76221702661007e-07 2.94950893124681e-06 1.16135009446301 0.892857142857143 15.3 15 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 8.32684912347596e-09 6.77091788726073e-08 1.16009458084738 0.891891891891892 15.3 15 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 8.32684912347596e-09 6.77091788726073e-08 1.16009458084738 0.891891891891892 15.3 15 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.71543359882356e-08 1.25646463488786e-07 1.15618853848762 0.888888888888889 15.3 15 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 8.65035631705739e-05 0.000295900409595497 1.15618853848762 0.888888888888889 15.3 15 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 8.65035631705739e-05 0.000295900409595497 1.15618853848762 0.888888888888889 15.3 15 3 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0070287784200338 0.0152468775788233 1.15618853848762 0.888888888888889 15.3 15 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0070287784200338 0.0152468775788233 1.15618853848762 0.888888888888889 15.3 15 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0070287784200338 0.0152468775788233 1.15618853848762 0.888888888888889 15.3 15 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0070287784200338 0.0152468775788233 1.15618853848762 0.888888888888889 15.3 15 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0070287784200338 0.0152468775788233 1.15618853848762 0.888888888888889 15.3 15 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 2.44302830094052e-06 1.10714308033069e-05 1.15062993974489 0.884615384615385 15.3 15 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.44302830094052e-06 1.10714308033069e-05 1.15062993974489 0.884615384615385 15.3 15 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 1.06847774063039e-09 1.0558637673035e-08 1.14946651210107 0.883720930232558 15.3 15 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.01817277123126e-13 9.52114647128278e-12 1.14896236012208 0.883333333333333 15.3 15 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.01817277123126e-13 9.52114647128278e-12 1.14896236012208 0.883333333333333 15.3 15 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.01817277123126e-13 9.52114647128278e-12 1.14896236012208 0.883333333333333 15.3 15 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.01817277123126e-13 9.52114647128278e-12 1.14896236012208 0.883333333333333 15.3 15 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.01817277123126e-13 9.52114647128278e-12 1.14896236012208 0.883333333333333 15.3 15 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.01817277123126e-13 9.52114647128278e-12 1.14896236012208 0.883333333333333 15.3 15 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.01817277123126e-13 9.52114647128278e-12 1.14896236012208 0.883333333333333 15.3 15 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000177990463103205 0.00057958908237039 1.14768715217521 0.882352941176471 15.3 15 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.000177990463103205 0.00057958908237039 1.14768715217521 0.882352941176471 15.3 15 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.000177990463103205 0.00057958908237039 1.14768715217521 0.882352941176471 15.3 15 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 1.46995065782201e-07 8.2506434387312e-07 1.14305003236845 0.878787878787879 15.3 15 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.98583183432179e-07 1.57364396305182e-06 1.13812309257375 0.875 15.3 15 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 1.01720381323772e-05 4.07741134151345e-05 1.13812309257375 0.875 15.3 15 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.000363795886401156 0.00110615715031804 1.13812309257375 0.875 15.3 15 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000363795886401156 0.00110615715031804 1.13812309257375 0.875 15.3 15 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.000363795886401156 0.00110615715031804 1.13812309257375 0.875 15.3 15 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000363795886401156 0.00110615715031804 1.13812309257375 0.875 15.3 15 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000363795886401156 0.00110615715031804 1.13812309257375 0.875 15.3 15 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000363795886401156 0.00110615715031804 1.13812309257375 0.875 15.3 15 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.000363795886401156 0.00110615715031804 1.13812309257375 0.875 15.3 15 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000363795886401156 0.00110615715031804 1.13812309257375 0.875 15.3 15 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0145192903417894 0.0291409734222374 1.13812309257375 0.875 15.3 15 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0145192903417894 0.0291409734222374 1.13812309257375 0.875 15.3 15 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0145192903417894 0.0291409734222374 1.13812309257375 0.875 15.3 15 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0145192903417894 0.0291409734222374 1.13812309257375 0.875 15.3 15 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0145192903417894 0.0291409734222374 1.13812309257375 0.875 15.3 15 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0145192903417894 0.0291409734222374 1.13812309257375 0.875 15.3 15 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0145192903417894 0.0291409734222374 1.13812309257375 0.875 15.3 15 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 6.04020160125266e-07 3.0697167423509e-06 1.13287828569553 0.870967741935484 15.3 15 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 2.05963704766828e-05 7.94271956323023e-05 1.13105400504224 0.869565217391304 15.3 15 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 2.05963704766828e-05 7.94271956323023e-05 1.13105400504224 0.869565217391304 15.3 15 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 2.05963704766828e-05 7.94271956323023e-05 1.13105400504224 0.869565217391304 15.3 15 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.2165896877242e-06 5.73247392593223e-06 1.12728382502543 0.866666666666667 15.3 15 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000737998574871052 0.00210034394408302 1.12728382502543 0.866666666666667 15.3 15 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000737998574871052 0.00210034394408302 1.12728382502543 0.866666666666667 15.3 15 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000737998574871052 0.00210034394408302 1.12728382502543 0.866666666666667 15.3 15 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.26181863979787e-09 2.05004326396967e-08 1.12728382502543 0.866666666666667 15.3 15 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.53007729546738e-09 3.81437869316573e-08 1.12334227318968 0.863636363636364 15.3 15 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 4.14642404259768e-05 0.000152464119189057 1.12334227318968 0.863636363636364 15.3 15 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 2.43901545941665e-06 1.10714308033069e-05 1.12130353948153 0.862068965517241 15.3 15 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.05339998823461e-14 1.7608751198698e-12 1.12005764665988 0.861111111111111 15.3 15 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 1.47270796446783e-07 8.2506434387312e-07 1.12005764665988 0.861111111111111 15.3 15 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.47270796446783e-07 8.2506434387312e-07 1.12005764665988 0.861111111111111 15.3 15 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.47270796446783e-07 8.2506434387312e-07 1.12005764665988 0.861111111111111 15.3 15 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 9.04253638337116e-09 7.31109617814611e-08 1.11921739336157 0.86046511627907 15.3 15 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.93267782511263e-07 1.55397970037359e-06 1.11489609068449 0.857142857142857 15.3 15 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 4.86541789714438e-06 2.13030451311891e-05 1.11489609068449 0.857142857142857 15.3 15 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 4.86541789714438e-06 2.13030451311891e-05 1.11489609068449 0.857142857142857 15.3 15 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 4.86541789714438e-06 2.13030451311891e-05 1.11489609068449 0.857142857142857 15.3 15 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00148441775414314 0.00389728129916178 1.11489609068449 0.857142857142857 15.3 15 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00148441775414314 0.00389728129916178 1.11489609068449 0.857142857142857 15.3 15 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00148441775414314 0.00389728129916178 1.11489609068449 0.857142857142857 15.3 15 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00148441775414314 0.00389728129916178 1.11489609068449 0.857142857142857 15.3 15 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00148441775414314 0.00389728129916178 1.11489609068449 0.857142857142857 15.3 15 3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0296011939340263 0.0547045441144408 1.11489609068449 0.857142857142857 15.3 15 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 8.29520087593361e-05 0.000285122484213853 1.11489609068449 0.857142857142857 15.3 15 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 8.29520087593361e-05 0.000285122484213853 1.11489609068449 0.857142857142857 15.3 15 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 8.29520087593361e-05 0.000285122484213853 1.11489609068449 0.857142857142857 15.3 15 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 5.81449267818169e-07 2.96559967062815e-06 1.10943091376937 0.852941176470588 15.3 15 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 9.65389793843645e-06 3.88135085839297e-05 1.10801401605064 0.851851851851852 15.3 15 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000164811235682158 0.000541631381930048 1.10560528992879 0.85 15.3 15 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000164811235682158 0.000541631381930048 1.10560528992879 0.85 15.3 15 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000164811235682158 0.000541631381930048 1.10560528992879 0.85 15.3 15 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.000164811235682158 0.000541631381930048 1.10560528992879 0.85 15.3 15 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000164811235682158 0.000541631381930048 1.10560528992879 0.85 15.3 15 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000164811235682158 0.000541631381930048 1.10560528992879 0.85 15.3 15 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 1.14747664227204e-06 5.53511614221393e-06 1.10363451401091 0.848484848484849 15.3 15 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 1.14747664227204e-06 5.53511614221393e-06 1.10363451401091 0.848484848484849 15.3 15 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00295687646203643 0.00720485480390041 1.10060255106033 0.846153846153846 15.3 15 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00295687646203643 0.00720485480390041 1.10060255106033 0.846153846153846 15.3 15 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00295687646203643 0.00720485480390041 1.10060255106033 0.846153846153846 15.3 15 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00295687646203643 0.00720485480390041 1.10060255106033 0.846153846153846 15.3 15 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00295687646203643 0.00720485480390041 1.10060255106033 0.846153846153846 15.3 15 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.68434814262446e-08 1.25646463488786e-07 1.09837911156324 0.844444444444444 15.3 15 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 2.25337983426794e-06 1.03104807207823e-05 1.09747583926755 0.84375 15.3 15 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000324974990529918 0.00101412151650016 1.09533651014617 0.842105263157895 15.3 15 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.15906790312658e-11 4.4072094374011e-10 1.09424986678293 0.841269841269841 15.3 15 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 3.28941058480059e-08 2.26127114114552e-07 1.09378063442153 0.840909090909091 15.3 15 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.73398777376688e-05 0.000139095931991368 1.0925981688708 0.84 15.3 15 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 3.73398777376688e-05 0.000139095931991368 1.0925981688708 0.84 15.3 15 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 3.73398777376688e-05 0.000139095931991368 1.0925981688708 0.84 15.3 15 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 8.7648661119441e-36 1.78177206818521e-33 1.09073167616293 0.838565022421525 15.3 15 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.48785572180509e-14 4.15140920025224e-13 1.08896827462206 0.837209302325581 15.3 15 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 6.39827107685287e-08 3.80951453655299e-07 1.08896827462206 0.837209302325581 15.3 15 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.70480612045316e-18 1.59755730588026e-16 1.0878683066679 0.836363636363636 15.3 15 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.47902704456889e-11 2.21542682570688e-10 1.08716235708538 0.835820895522388 15.3 15 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.47902704456889e-11 2.21542682570688e-10 1.08716235708538 0.835820895522388 15.3 15 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.51421967946774e-08 1.20376234853776e-07 1.08392675483215 0.833333333333333 15.3 15 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 1.51421967946774e-08 1.20376234853776e-07 1.08392675483215 0.833333333333333 15.3 15 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 8.55114431787897e-06 3.46984382932676e-05 1.08392675483215 0.833333333333333 15.3 15 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 7.27180321982103e-05 0.000256768634784251 1.08392675483215 0.833333333333333 15.3 15 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00063542496276636 0.0018266863071041 1.08392675483215 0.833333333333333 15.3 15 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00063542496276636 0.0018266863071041 1.08392675483215 0.833333333333333 15.3 15 3 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.00063542496276636 0.0018266863071041 1.08392675483215 0.833333333333333 15.3 15 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00582424102927333 0.0132818829882307 1.08392675483215 0.833333333333333 15.3 15 3 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 SCAVENGING BY CLASS B RECEPTORS%REACTOME%REACT_196592.2 SCAVENGING BY CLASS B RECEPTORS 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.0593472449596843 0.0986578616561107 1.08392675483215 0.833333333333333 15.3 15 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.91894410946478e-08 2.04613668362974e-07 1.07931430055627 0.829787234042553 15.3 15 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.91894410946478e-08 2.04613668362974e-07 1.07931430055627 0.829787234042553 15.3 15 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 1.97432644680154e-06 9.15135678761758e-06 1.07773288766168 0.828571428571429 15.3 15 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 9.11970648225307e-20 4.63476511580218e-18 1.07539189849489 0.826771653543307 15.3 15 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.6039097736447e-08 3.37896763046458e-07 1.07450130479013 0.826086956521739 15.3 15 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 5.6039097736447e-08 3.37896763046458e-07 1.07450130479013 0.826086956521739 15.3 15 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000140586622685124 0.000476320866859361 1.07450130479013 0.826086956521739 15.3 15 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.80651753557946e-13 4.43219733298203e-12 1.07117467536353 0.823529411764706 15.3 15 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 3.7889377230568e-06 1.67442806829498e-05 1.07117467536353 0.823529411764706 15.3 15 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.7889377230568e-06 1.67442806829498e-05 1.07117467536353 0.823529411764706 15.3 15 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 3.7889377230568e-06 1.67442806829498e-05 1.07117467536353 0.823529411764706 15.3 15 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00123088786179159 0.00335546633588013 1.07117467536353 0.823529411764706 15.3 15 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 8.02060334837314e-20 4.53391109236385e-18 1.0705861178496 0.823076923076923 15.3 15 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.86526192086479e-10 4.26377342123302e-09 1.06994060315689 0.82258064516129 15.3 15 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 3.86526192086479e-10 4.26377342123302e-09 1.06994060315689 0.82258064516129 15.3 15 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.6508388093466e-16 6.18195690973741e-15 1.06974453561004 0.822429906542056 15.3 15 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.32731577684925e-14 1.14032784267713e-12 1.06947439810105 0.822222222222222 15.3 15 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.43956997679216e-13 7.30523593578395e-12 1.06844208690597 0.821428571428571 15.3 15 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.43956997679216e-13 7.30523593578395e-12 1.06844208690597 0.821428571428571 15.3 15 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 9.17687057665925e-11 1.17645827302578e-09 1.067748743566 0.82089552238806 15.3 15 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.4850634922569e-15 7.68748989017732e-14 1.06658392675483 0.82 15.3 15 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.71489927493165e-30 1.87715512940595e-28 1.06534515332074 0.819047619047619 15.3 15 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.56161391645042e-23 1.16956663321524e-21 1.06495803662258 0.81875 15.3 15 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000269646966259453 0.000847036717411041 1.06421899565338 0.818181818181818 15.3 15 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000269646966259453 0.000847036717411041 1.06421899565338 0.818181818181818 15.3 15 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000269646966259453 0.000847036717411041 1.06421899565338 0.818181818181818 15.3 15 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0113231364330542 0.0233519176003422 1.06421899565338 0.818181818181818 15.3 15 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.39415123937443e-09 1.30518237738803e-08 1.0622482197355 0.816666666666667 15.3 15 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.39415123937443e-09 1.30518237738803e-08 1.0622482197355 0.816666666666667 15.3 15 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 9.82540101020363e-12 1.53643358654063e-10 1.0611072442041 0.815789473684211 15.3 15 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 6.03670336182921e-05 0.000215834896579974 1.05983949361365 0.814814814814815 15.3 15 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 6.03670336182921e-05 0.000215834896579974 1.05983949361365 0.814814814814815 15.3 15 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.63384691931181e-09 2.34247760386294e-08 1.05820645895477 0.813559322033898 15.3 15 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.63384691931181e-09 2.34247760386294e-08 1.05820645895477 0.813559322033898 15.3 15 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.8535913755507e-11 2.74756304938401e-10 1.05791251271618 0.813333333333333 15.3 15 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 9.00608330611882e-08 5.18852491684497e-07 1.05682858596134 0.8125 15.3 15 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00235954355824061 0.00591132127354997 1.05682858596134 0.8125 15.3 15 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00235954355824061 0.00591132127354997 1.05682858596134 0.8125 15.3 15 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00235954355824061 0.00591132127354997 1.05682858596134 0.8125 15.3 15 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00235954355824061 0.00591132127354997 1.05682858596134 0.8125 15.3 15 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00235954355824061 0.00591132127354997 1.05682858596134 0.8125 15.3 15 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 3.48658385321391e-11 4.77058540684942e-10 1.05463143713398 0.810810810810811 15.3 15 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 3.48658385321391e-11 4.77058540684942e-10 1.05463143713398 0.810810810810811 15.3 15 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 8.2772618790696e-12 1.30872707265734e-10 1.05374145279885 0.810126582278481 15.3 15 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.42033841996375e-14 4.04228314321684e-13 1.05357680569685 0.81 15.3 15 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.16862508061749e-09 1.1236172227829e-08 1.0529574189798 0.80952380952381 15.3 15 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.16862508061749e-09 1.1236172227829e-08 1.0529574189798 0.80952380952381 15.3 15 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 7.27996354620463e-07 3.62216368050671e-06 1.0529574189798 0.80952380952381 15.3 15 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 7.27996354620463e-07 3.62216368050671e-06 1.0529574189798 0.80952380952381 15.3 15 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000512712950104153 0.00151998026666294 1.0529574189798 0.80952380952381 15.3 15 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.69404314668487e-07 9.30742624607171e-07 1.05163957490098 0.808510638297872 15.3 15 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 6.53840349587215e-11 8.45831652238733e-10 1.05126046907008 0.808219178082192 15.3 15 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 3.96078846268104e-08 2.67118577364697e-07 1.05057516237577 0.807692307692308 15.3 15 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2.5839448845547e-05 9.85778437190708e-05 1.04896137564401 0.806451612903226 15.3 15 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 2.5839448845547e-05 9.85778437190708e-05 1.04896137564401 0.806451612903226 15.3 15 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.95136731117166e-18 2.07229284817567e-16 1.04863611630273 0.806201550387597 15.3 15 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.9716972199154e-14 1.28631366253448e-12 1.04853322814375 0.806122448979592 15.3 15 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 5.91448905895421e-06 2.57379753238283e-05 1.04779586300441 0.805555555555556 15.3 15 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 4.08429525780697e-09 3.45949532848769e-08 1.04483431449394 0.80327868852459 15.3 15 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.08429525780697e-09 3.45949532848769e-08 1.04483431449394 0.80327868852459 15.3 15 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 4.08429525780697e-09 3.45949532848769e-08 1.04483431449394 0.80327868852459 15.3 15 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.27779945247372e-10 2.63521026087e-09 1.04423366240167 0.802816901408451 15.3 15 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 2.27779945247372e-10 2.63521026087e-09 1.04423366240167 0.802816901408451 15.3 15 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.22958726114975e-08 2.23092362748354e-07 1.04056968463886 0.8 15.3 15 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.22958726114975e-08 2.23092362748354e-07 1.04056968463886 0.8 15.3 15 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.22958726114975e-08 2.23092362748354e-07 1.04056968463886 0.8 15.3 15 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000214230650040375 0.000689706368795144 1.04056968463886 0.8 15.3 15 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000214230650040375 0.000689706368795144 1.04056968463886 0.8 15.3 15 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000214230650040375 0.000689706368795144 1.04056968463886 0.8 15.3 15 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.37654903212365e-11 3.48642193063087e-10 1.04056968463886 0.8 15.3 15 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.00185537638665e-10 1.21849589794718e-09 1.04056968463886 0.8 15.3 15 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.00185537638665e-10 1.21849589794718e-09 1.04056968463886 0.8 15.3 15 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.00185537638665e-10 1.21849589794718e-09 1.04056968463886 0.8 15.3 15 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.00185537638665e-10 1.21849589794718e-09 1.04056968463886 0.8 15.3 15 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.00185537638665e-10 1.21849589794718e-09 1.04056968463886 0.8 15.3 15 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 4.23063209656012e-10 4.63091497954234e-09 1.04056968463886 0.8 15.3 15 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.79011064006763e-09 1.64343705859112e-08 1.04056968463886 0.8 15.3 15 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.79011064006763e-09 1.64343705859112e-08 1.04056968463886 0.8 15.3 15 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 4.83561707196711e-05 0.000174204635276182 1.04056968463886 0.8 15.3 15 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000965630009920955 0.00267854094369887 1.04056968463886 0.8 15.3 15 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000965630009920955 0.00267854094369887 1.04056968463886 0.8 15.3 15 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.000965630009920955 0.00267854094369887 1.04056968463886 0.8 15.3 15 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000965630009920955 0.00267854094369887 1.04056968463886 0.8 15.3 15 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.000965630009920955 0.00267854094369887 1.04056968463886 0.8 15.3 15 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000965630009920955 0.00267854094369887 1.04056968463886 0.8 15.3 15 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00447009447123148 0.0104966079745254 1.04056968463886 0.8 15.3 15 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00447009447123148 0.0104966079745254 1.04056968463886 0.8 15.3 15 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00447009447123148 0.0104966079745254 1.04056968463886 0.8 15.3 15 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00447009447123148 0.0104966079745254 1.04056968463886 0.8 15.3 15 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00447009447123148 0.0104966079745254 1.04056968463886 0.8 15.3 15 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0216765225203655 0.0412375555434227 1.04056968463886 0.8 15.3 15 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 3.27064647753894e-32 4.23102721594356e-30 1.0395249359595 0.799196787148594 15.3 15 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 4.58175553230381e-16 1.51624142382984e-14 1.03838361387281 0.798319327731092 15.3 15 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 7.83096954151039e-10 8.0168846457333e-09 1.03679950462205 0.797101449275362 15.3 15 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 7.83096954151039e-10 8.0168846457333e-09 1.03679950462205 0.797101449275362 15.3 15 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 7.83096954151039e-10 8.0168846457333e-09 1.03679950462205 0.797101449275362 15.3 15 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 3.31404954665365e-09 2.85811666962918e-08 1.03650495930824 0.796875 15.3 15 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.30894046520825e-22 1.56458203904349e-20 1.03603231682794 0.796511627906977 15.3 15 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 5.98171508395289e-08 3.5764624220441e-07 1.03575223239516 0.796296296296296 15.3 15 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 5.98171508395289e-08 3.5764624220441e-07 1.03575223239516 0.796296296296296 15.3 15 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.09524731927999e-06 5.31923868715162e-06 1.03465735688523 0.795454545454545 15.3 15 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.09524731927999e-06 5.31923868715162e-06 1.03465735688523 0.795454545454545 15.3 15 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 3.72798096655814e-16 1.29388217449079e-14 1.03417273985624 0.795081967213115 15.3 15 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 2.05023977454213e-05 7.94271956323023e-05 1.03291843695769 0.794117647058823 15.3 15 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 4.79152865741338e-13 9.52114647128278e-12 1.03252404274732 0.793814432989691 15.3 15 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.59272253459608e-08 1.83554436155733e-07 1.03159925632301 0.793103448275862 15.3 15 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.59272253459608e-08 1.83554436155733e-07 1.03159925632301 0.793103448275862 15.3 15 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.59272253459608e-08 1.83554436155733e-07 1.03159925632301 0.793103448275862 15.3 15 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.59272253459608e-08 1.83554436155733e-07 1.03159925632301 0.793103448275862 15.3 15 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.9827806160593e-05 0.000306534695842983 1.03159925632301 0.793103448275862 15.3 15 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.54611280231219e-11 4.80582715970499e-10 1.03105227898668 0.792682926829268 15.3 15 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.50565655632897e-20 1.5502388172418e-18 1.03075298950076 0.792452830188679 15.3 15 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 1.10301008787501e-07 6.32896514131505e-07 1.03075298950076 0.792452830188679 15.3 15 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.64284980739509e-23 2.59188763796161e-21 1.03061888164368 0.792349726775956 15.3 15 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 6.2885641672463e-10 6.57987265440551e-09 1.02973041709054 0.791666666666667 15.3 15 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000398487266535395 0.00118629159054365 1.02973041709054 0.791666666666667 15.3 15 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.000398487266535395 0.00118629159054365 1.02973041709054 0.791666666666667 15.3 15 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000398487266535395 0.00118629159054365 1.02973041709054 0.791666666666667 15.3 15 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000398487266535395 0.00118629159054365 1.02973041709054 0.791666666666667 15.3 15 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000398487266535395 0.00118629159054365 1.02973041709054 0.791666666666667 15.3 15 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 9.94020363093357e-52 3.53622744170462e-49 1.02896708838995 0.791079812206573 15.3 15 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 2.65467203496914e-09 2.3463343514044e-08 1.02892151652723 0.791044776119403 15.3 15 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.19835969744048e-14 6.01589586434193e-13 1.0287450291316 0.790909090909091 15.3 15 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.24583299783981e-33 3.55091150658449e-31 1.02813640715696 0.790441176470588 15.3 15 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 8.41184218758814e-20 4.53391109236385e-18 1.02731401986639 0.789808917197452 15.3 15 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00179961235865301 0.00461414123669051 1.02687797826203 0.789473684210526 15.3 15 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00179961235865301 0.00461414123669051 1.02687797826203 0.789473684210526 15.3 15 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 2.02455919282065e-07 1.10381139133479e-06 1.02556146803349 0.788461538461538 15.3 15 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.97968003939196e-35 3.52135587006844e-33 1.02547609706304 0.78839590443686 15.3 15 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.83201504242729e-11 3.99005683700399e-10 1.02526718927652 0.788235294117647 15.3 15 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.83201504242729e-11 3.99005683700399e-10 1.02526718927652 0.788235294117647 15.3 15 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.83201504242729e-11 3.99005683700399e-10 1.02526718927652 0.788235294117647 15.3 15 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.10322068396617e-09 1.91851476492555e-08 1.02198808312745 0.785714285714286 15.3 15 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 8.70509111127041e-08 5.03550595582837e-07 1.02198808312745 0.785714285714286 15.3 15 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 8.70509111127041e-08 5.03550595582837e-07 1.02198808312745 0.785714285714286 15.3 15 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.00835589172431184 0.0178000507839757 1.02198808312745 0.785714285714286 15.3 15 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00835589172431184 0.0178000507839757 1.02198808312745 0.785714285714286 15.3 15 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00835589172431184 0.0178000507839757 1.02198808312745 0.785714285714286 15.3 15 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00835589172431184 0.0178000507839757 1.02198808312745 0.785714285714286 15.3 15 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.00835589172431184 0.0178000507839757 1.02198808312745 0.785714285714286 15.3 15 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.00835589172431184 0.0178000507839757 1.02198808312745 0.785714285714286 15.3 15 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 3.6982483652522e-07 1.9206596437058e-06 1.02016635748908 0.784313725490196 15.3 15 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.6982483652522e-07 1.9206596437058e-06 1.02016635748908 0.784313725490196 15.3 15 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 9.39054892087601e-11 1.19310277807201e-09 1.01862996237238 0.783132530120482 15.3 15 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.57633223165937e-06 7.37868672911605e-06 1.01794860453802 0.782608695652174 15.3 15 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000734264203127039 0.00210034394408302 1.01794860453802 0.782608695652174 15.3 15 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.58435064489975e-07 8.77249403771342e-07 1.01692037362434 0.781818181818182 15.3 15 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.58435064489975e-07 8.77249403771342e-07 1.01692037362434 0.781818181818182 15.3 15 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.58435064489975e-07 8.77249403771342e-07 1.01692037362434 0.781818181818182 15.3 15 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.06892919088119e-11 5.41129555011583e-10 1.01664854246325 0.781609195402299 15.3 15 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.06892919088119e-11 5.41129555011583e-10 1.01664854246325 0.781609195402299 15.3 15 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 8.51858191441595e-22 5.50997366555177e-20 1.01640344879342 0.781420765027322 15.3 15 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.36655127864271e-20 1.99608436229524e-18 1.01594081636338 0.781065088757396 15.3 15 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.65059908325115e-09 1.53516502971659e-08 1.01562452096601 0.780821917808219 15.3 15 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.01313372175093e-30 3.06263520432255e-28 1.01555599029658 0.780769230769231 15.3 15 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 6.74590795325471e-06 2.78244261376274e-05 1.01518993623303 0.780487804878049 15.3 15 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 6.74590795325471e-06 2.78244261376274e-05 1.01518993623303 0.780487804878049 15.3 15 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 6.74590795325471e-06 2.78244261376274e-05 1.01518993623303 0.780487804878049 15.3 15 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 6.74590795325471e-06 2.78244261376274e-05 1.01518993623303 0.780487804878049 15.3 15 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.83215595403032e-12 3.30019990200651e-11 1.01455544252289 0.78 15.3 15 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 6.79219361296679e-08 4.02720479635489e-07 1.01411452316499 0.779661016949153 15.3 15 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.73826643617146e-30 7.34103542578132e-28 1.01166497117667 0.777777777777778 15.3 15 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.0741230746767e-10 3.44447018524799e-09 1.01166497117667 0.777777777777778 15.3 15 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.0741230746767e-10 3.44447018524799e-09 1.01166497117667 0.777777777777778 15.3 15 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.98354582698098e-09 2.60465381091653e-08 1.01166497117667 0.777777777777778 15.3 15 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.98354582698098e-09 2.60465381091653e-08 1.01166497117667 0.777777777777778 15.3 15 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.86994511605401e-07 1.52956250941755e-06 1.01166497117667 0.777777777777778 15.3 15 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.86048327400064e-06 1.28812268952624e-05 1.01166497117667 0.777777777777778 15.3 15 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000302513875481487 0.000946103834747595 1.01166497117667 0.777777777777778 15.3 15 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000302513875481487 0.000946103834747595 1.01166497117667 0.777777777777778 15.3 15 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00331500800837989 0.00796833850662936 1.01166497117667 0.777777777777778 15.3 15 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00331500800837989 0.00796833850662936 1.01166497117667 0.777777777777778 15.3 15 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.00331500800837989 0.00796833850662936 1.01166497117667 0.777777777777778 15.3 15 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00331500800837989 0.00796833850662936 1.01166497117667 0.777777777777778 15.3 15 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00331500800837989 0.00796833850662936 1.01166497117667 0.777777777777778 15.3 15 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00331500800837989 0.00796833850662936 1.01166497117667 0.777777777777778 15.3 15 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0407360820679339 0.0708648469225794 1.01166497117667 0.777777777777778 15.3 15 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 8.98634289669141e-59 6.39378297099594e-56 1.011390211543 0.777566539923954 15.3 15 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.7122264021629e-16 6.24743120584052e-15 1.01062523328235 0.776978417266187 15.3 15 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 8.60264226941841e-20 4.53391109236385e-18 1.00996469391419 0.776470588235294 15.3 15 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.32690878052387e-10 1.60016202939446e-09 1.00996469391419 0.776470588235294 15.3 15 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 1.21538560260448e-06 5.73247392593223e-06 1.0087155106193 0.775510204081633 15.3 15 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.40835689316854e-41 3.34015309829805e-39 1.00857355797216 0.775401069518717 15.3 15 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.22172761032816e-05 4.86979941035565e-05 1.0080518819939 0.775 15.3 15 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.47318908343471e-11 3.5911714956404e-10 1.00700292061825 0.774193548387097 15.3 15 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 5.17318530138503e-07 2.65756053569346e-06 1.0062112516555 0.773584905660377 15.3 15 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.14536418165119e-18 5.25759106609564e-17 1.00545843761117 0.773006134969325 15.3 15 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.20031460207869e-24 1.00473392868116e-22 1.00509571811708 0.772727272727273 15.3 15 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00133913729517613 0.00356185489913202 1.00509571811708 0.772727272727273 15.3 15 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00133913729517613 0.00356185489913202 1.00509571811708 0.772727272727273 15.3 15 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00133913729517613 0.00356185489913202 1.00509571811708 0.772727272727273 15.3 15 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 9.92852660540113e-10 9.87992542621385e-09 1.0043473221989 0.772151898734177 15.3 15 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 9.92852660540113e-10 9.87992542621385e-09 1.0043473221989 0.772151898734177 15.3 15 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 9.92852660540113e-10 9.87992542621385e-09 1.0043473221989 0.772151898734177 15.3 15 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 4.28328925010299e-16 1.45121919116585e-14 1.00340648161604 0.771428571428571 15.3 15 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 5.24130730914558e-05 0.000188342936891772 1.00340648161604 0.771428571428571 15.3 15 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 9.27721227335726e-07 4.55223209137496e-06 1.00054777369121 0.769230769230769 15.3 15 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 9.27721227335726e-07 4.55223209137496e-06 1.00054777369121 0.769230769230769 15.3 15 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 2.19813722471155e-05 8.43113010987746e-05 1.00054777369121 0.769230769230769 15.3 15 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 2.19813722471155e-05 8.43113010987746e-05 1.00054777369121 0.769230769230769 15.3 15 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000547741340437543 0.00160564190791841 1.00054777369121 0.769230769230769 15.3 15 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.015382122920063 0.0303106738362899 1.00054777369121 0.769230769230769 15.3 15 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.015382122920063 0.0303106738362899 1.00054777369121 0.769230769230769 15.3 15 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.015382122920063 0.0303106738362899 1.00054777369121 0.769230769230769 15.3 15 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.72178920451955e-08 1.25646463488786e-07 0.999097704453978 0.768115942028985 15.3 15 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 5.6018876032869e-15 1.6607262623911e-13 0.997538607454547 0.766917293233083 15.3 15 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.07325714653038e-24 3.22013606639596e-22 0.997407040769312 0.766816143497758 15.3 15 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000226091751180764 0.000726249575463266 0.997212614445575 0.766666666666667 15.3 15 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.72937899625996e-12 4.73647111180234e-11 0.996807408182086 0.766355140186916 15.3 15 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 7.17109241821217e-08 4.23421763946719e-07 0.995857706002034 0.765625 15.3 15 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 5.82224418002688e-10 6.137076643095e-09 0.994662198551852 0.764705882352941 15.3 15 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 5.82224418002688e-10 6.137076643095e-09 0.994662198551852 0.764705882352941 15.3 15 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00602767457169992 0.0135503647954644 0.994662198551852 0.764705882352941 15.3 15 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00602767457169992 0.0135503647954644 0.994662198551852 0.764705882352941 15.3 15 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00602767457169992 0.0135503647954644 0.994662198551852 0.764705882352941 15.3 15 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00602767457169992 0.0135503647954644 0.994662198551852 0.764705882352941 15.3 15 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00602767457169992 0.0135503647954644 0.994662198551852 0.764705882352941 15.3 15 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00602767457169992 0.0135503647954644 0.994662198551852 0.764705882352941 15.3 15 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00602767457169992 0.0135503647954644 0.994662198551852 0.764705882352941 15.3 15 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.85507203218484e-15 5.86615000399785e-14 0.99411568086034 0.764285714285714 15.3 15 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.07861610235027e-14 1.09506994597065e-12 0.99345727765718 0.763779527559055 15.3 15 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 7.0234041767062e-07 3.53155623443566e-06 0.993271062609822 0.763636363636364 15.3 15 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.49590151663048e-16 5.7531563734194e-15 0.992648712319966 0.763157894736842 15.3 15 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 3.92758083310123e-05 0.000145545508476642 0.992648712319966 0.763157894736842 15.3 15 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 5.51373206564369e-19 2.61534690980366e-17 0.9920685552701 0.76271186440678 15.3 15 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 1.64874720099772e-05 6.48112504701588e-05 0.991018747275105 0.761904761904762 15.3 15 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00241496460133473 0.00602893794333215 0.991018747275105 0.761904761904762 15.3 15 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 3.68655683285978e-12 6.17172985077585e-11 0.990450502580567 0.761467889908257 15.3 15 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 6.94641840872287e-06 2.85686514324065e-05 0.98967225441196 0.760869565217391 15.3 15 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 2.93552271637115e-06 1.31774410895778e-05 0.988541200406918 0.76 15.3 15 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.000981966552102956 0.00269756448579634 0.988541200406918 0.76 15.3 15 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.000981966552102956 0.00269756448579634 0.988541200406918 0.76 15.3 15 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000981966552102956 0.00269756448579634 0.988541200406918 0.76 15.3 15 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000981966552102956 0.00269756448579634 0.988541200406918 0.76 15.3 15 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.000981966552102956 0.00269756448579634 0.988541200406918 0.76 15.3 15 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.49742999832368e-12 1.03885875141737e-10 0.987577709958178 0.759259259259259 15.3 15 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.2360577798191e-13 4.90590448999917e-12 0.986023693105372 0.758064516129032 15.3 15 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.2360577798191e-13 4.90590448999917e-12 0.986023693105372 0.758064516129032 15.3 15 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.2360577798191e-13 4.90590448999917e-12 0.986023693105372 0.758064516129032 15.3 15 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.000167150298033494 0.000548052705303369 0.985387958938315 0.757575757575758 15.3 15 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 6.1754930106096e-11 8.06213445330042e-10 0.985387958938315 0.757575757575758 15.3 15 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 6.1754930106096e-11 8.06213445330042e-10 0.985387958938315 0.757575757575758 15.3 15 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 6.96651871965372e-05 0.000246600898956897 0.984322674658382 0.756756756756757 15.3 15 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 6.96651871965372e-05 0.000246600898956897 0.984322674658382 0.756756756756757 15.3 15 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 6.96651871965372e-05 0.000246600898956897 0.984322674658382 0.756756756756757 15.3 15 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 7.46621780964073e-09 6.17699299018533e-08 0.983871977463025 0.756410256410256 15.3 15 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.19683998115216e-09 2.77384347145093e-08 0.983465250725752 0.75609756097561 15.3 15 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 2.91785173683642e-05 0.000110428271848889 0.983465250725752 0.75609756097561 15.3 15 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.91785173683642e-05 0.000110428271848889 0.983465250725752 0.75609756097561 15.3 15 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.37001626000805e-09 1.29968875866097e-08 0.983096359033807 0.755813953488372 15.3 15 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.37001626000805e-09 1.29968875866097e-08 0.983096359033807 0.755813953488372 15.3 15 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.35419547644726e-14 3.93269421017236e-13 0.982552310135615 0.755395683453237 15.3 15 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.19049875717336e-06 1.0055095907928e-05 0.981669513810246 0.754716981132076 15.3 15 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 2.19049875717336e-06 1.0055095907928e-05 0.981669513810246 0.754716981132076 15.3 15 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.12628257075646e-11 1.74206532411571e-10 0.975534079348932 0.75 15.3 15 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.34288379040634e-08 3.24911266399497e-07 0.975534079348932 0.75 15.3 15 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00174159501290196 0.00448153653410395 0.975534079348932 0.75 15.3 15 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0278198226443968 0.0520889573986535 0.975534079348932 0.75 15.3 15 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0278198226443968 0.0520889573986535 0.975534079348932 0.75 15.3 15 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0278198226443968 0.0520889573986535 0.975534079348932 0.75 15.3 15 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0278198226443968 0.0520889573986535 0.975534079348932 0.75 15.3 15 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 2.93760041743146e-07 1.55397970037359e-06 0.975534079348932 0.75 15.3 15 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0108017472102041 0.0226375350222687 0.975534079348932 0.75 15.3 15 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0108017472102041 0.0226375350222687 0.975534079348932 0.75 15.3 15 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0108017472102041 0.0226375350222687 0.975534079348932 0.75 15.3 15 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.074846904710737 0.12144486362985 0.975534079348932 0.75 15.3 15 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.074846904710737 0.12144486362985 0.975534079348932 0.75 15.3 15 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.074846904710737 0.12144486362985 0.975534079348932 0.75 15.3 15 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.074846904710737 0.12144486362985 0.975534079348932 0.75 15.3 15 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.074846904710737 0.12144486362985 0.975534079348932 0.75 15.3 15 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.074846904710737 0.12144486362985 0.975534079348932 0.75 15.3 15 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.074846904710737 0.12144486362985 0.975534079348932 0.75 15.3 15 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 7.2657941060738e-09 6.04633041692575e-08 0.971616271801346 0.746987951807229 15.3 15 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.17667506877817e-07 1.18221703163028e-06 0.970680675969086 0.746268656716418 15.3 15 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 3.75308625443426e-05 0.000139442343082505 0.967971799664056 0.744186046511628 15.3 15 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.6644092833063e-12 7.54256182971008e-11 0.967471814230346 0.743801652892562 15.3 15 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.6644092833063e-12 7.54256182971008e-11 0.967471814230346 0.743801652892562 15.3 15 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.000515131000818612 0.00152397383402263 0.965044465592492 0.741935483870968 15.3 15 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.16754471678321e-08 1.57368169999108e-07 0.963490448739686 0.740740740740741 15.3 15 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00124839124031199 0.00339019224229764 0.963490448739686 0.740740740740741 15.3 15 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00124839124031199 0.00339019224229764 0.963490448739686 0.740740740740741 15.3 15 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.29932055131559e-15 1.60445386053661e-13 0.963185546698945 0.740506329113924 15.3 15 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.18302452904872e-07 6.73377561934531e-07 0.962170598809905 0.73972602739726 15.3 15 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.73545224038533e-05 0.000104078837916265 0.961395904285904 0.739130434782609 15.3 15 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 8.68506548665299e-08 5.03550595582837e-07 0.958419446377898 0.736842105263158 15.3 15 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00755811582761513 0.0162957557919641 0.958419446377898 0.736842105263158 15.3 15 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00755811582761513 0.0162957557919641 0.958419446377898 0.736842105263158 15.3 15 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000370413211588732 0.0011214851065761 0.956405960146012 0.735294117647059 15.3 15 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000370413211588732 0.0011214851065761 0.956405960146012 0.735294117647059 15.3 15 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.38757457888046e-12 4.1944674391937e-11 0.955826320170166 0.734848484848485 15.3 15 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.16750809382511e-10 2.54906117149846e-09 0.954651086824643 0.73394495412844 15.3 15 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000891492574873301 0.00251206719612813 0.953855544252289 0.733333333333333 15.3 15 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0190418341702829 0.0369162534391179 0.953855544252289 0.733333333333333 15.3 15 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0190418341702829 0.0369162534391179 0.953855544252289 0.733333333333333 15.3 15 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 8.53984298701504e-10 8.680140407516e-09 0.950520385006652 0.730769230769231 15.3 15 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00216057784090908 0.00547064460429471 0.950520385006652 0.730769230769231 15.3 15 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00216057784090908 0.00547064460429471 0.950520385006652 0.730769230769231 15.3 15 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.69667234681661e-10 3.06989179961603e-09 0.949168293420582 0.72972972972973 15.3 15 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.000635106510471546 0.0018266863071041 0.945972440580783 0.727272727272727 15.3 15 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.47115049424529e-08 1.78499855498022e-07 0.945972440580782 0.727272727272727 15.3 15 3 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0492855520865293 0.0844980007459412 0.945972440580782 0.727272727272727 15.3 15 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0492855520865293 0.0844980007459412 0.945972440580782 0.727272727272727 15.3 15 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0492855520865293 0.0844980007459412 0.945972440580782 0.727272727272727 15.3 15 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 7.75728522097989e-09 6.3807033927482e-08 0.944727740001071 0.726315789473684 15.3 15 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.20992848880261e-06 1.43639252816545e-05 0.944065238079611 0.725806451612903 15.3 15 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00019002279629933 0.000615950886409902 0.943016276703967 0.725 15.3 15 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.00019002279629933 0.000615950886409902 0.943016276703967 0.725 15.3 15 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 9.94855095656012e-07 4.86487560521823e-06 0.942545004201866 0.72463768115942 15.3 15 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.16616982491824e-08 2.78331439476932e-07 0.941894973164486 0.724137931034483 15.3 15 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00152682894678812 0.00398656438766879 0.941894973164486 0.724137931034483 15.3 15 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00152682894678812 0.00398656438766879 0.941894973164486 0.724137931034483 15.3 15 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00152682894678812 0.00398656438766879 0.941894973164486 0.724137931034483 15.3 15 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.65449274729361e-17 6.72669479828231e-16 0.94146780991135 0.723809523809524 15.3 15 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.09507205704201e-07 1.62519835319955e-06 0.941304813406864 0.723684210526316 15.3 15 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.000451764753804316 0.00134209028113474 0.939403187521194 0.722222222222222 15.3 15 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.013080607636332 0.026629048163806 0.939403187521194 0.722222222222222 15.3 15 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.013080607636332 0.026629048163806 0.939403187521194 0.722222222222222 15.3 15 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.013080607636332 0.026629048163806 0.939403187521194 0.722222222222222 15.3 15 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.67321341507246e-06 7.78098918185659e-06 0.937277840943091 0.720588235294118 15.3 15 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 4.12473110520247e-05 0.000152059387634796 0.936512716174975 0.72 15.3 15 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 4.12473110520247e-05 0.000152059387634796 0.936512716174975 0.72 15.3 15 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00107826371946921 0.00294504658887656 0.934886826042726 0.71875 15.3 15 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 6.37434741463962e-66 9.07069637103217e-63 0.931392265803731 0.71606334841629 15.3 15 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.57909090747832e-10 2.95971480753358e-09 0.930590774880282 0.715447154471545 15.3 15 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 6.90983186347187e-05 0.000246433351922819 0.929080075570411 0.714285714285714 15.3 15 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.87739671969816e-16 6.6788388303262e-15 0.929080075570411 0.714285714285714 15.3 15 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.00076133295722766 0.00215383061259436 0.929080075570411 0.714285714285714 15.3 15 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00258585184438686 0.00643298457091346 0.929080075570411 0.714285714285714 15.3 15 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0329477009094409 0.0603405127337636 0.929080075570411 0.714285714285714 15.3 15 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0329477009094409 0.0603405127337636 0.929080075570411 0.714285714285714 15.3 15 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0329477009094409 0.0603405127337636 0.929080075570411 0.714285714285714 15.3 15 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.133712372523829 0.198330623800944 0.929080075570411 0.714285714285714 15.3 15 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000228005521890756 0.000730747427140869 0.929080075570411 0.714285714285714 15.3 15 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0090180464136353 0.0191532538009001 0.929080075570411 0.714285714285714 15.3 15 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 9.71342894856761e-13 1.81871176234365e-11 0.926757375381485 0.7125 15.3 15 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 1.51003591514859e-05 5.98546269430765e-05 0.925930651585427 0.711864406779661 15.3 15 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00181148753367365 0.00462791159859534 0.923086010566731 0.709677419354839 15.3 15 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00181148753367365 0.00462791159859534 0.923086010566731 0.709677419354839 15.3 15 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00623765001774746 0.0139343421903527 0.921337741607325 0.708333333333333 15.3 15 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00623765001774746 0.0139343421903527 0.921337741607325 0.708333333333333 15.3 15 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.66216066000798e-07 9.16765356275722e-07 0.92072879399225 0.707865168539326 15.3 15 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.37217115474732e-12 2.53584357559148e-11 0.920015879711188 0.707317073170732 15.3 15 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000379706126474234 0.00114232942488972 0.920015879711188 0.707317073170732 15.3 15 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000379706126474234 0.00114232942488972 0.920015879711188 0.707317073170732 15.3 15 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000379706126474234 0.00114232942488972 0.920015879711188 0.707317073170732 15.3 15 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 5.15986337013046e-14 1.31115813851708e-12 0.918149721740171 0.705882352941177 15.3 15 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0012703704277903 0.00340352296799254 0.918149721740171 0.705882352941177 15.3 15 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0012703704277903 0.00340352296799254 0.918149721740171 0.705882352941177 15.3 15 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.0222595215426142 0.0421774955461252 0.918149721740171 0.705882352941177 15.3 15 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0222595215426142 0.0421774955461252 0.918149721740171 0.705882352941177 15.3 15 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0222595215426142 0.0421774955461252 0.918149721740171 0.705882352941177 15.3 15 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 8.55093519608208e-08 5.00739949959868e-07 0.917344327247417 0.705263157894737 15.3 15 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 8.55093519608208e-08 5.00739949959868e-07 0.917344327247417 0.705263157894737 15.3 15 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00432702101732718 0.0102451762190625 0.915315926302701 0.703703703703704 15.3 15 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00432702101732718 0.0102451762190625 0.915315926302701 0.703703703703704 15.3 15 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00432702101732718 0.0102451762190625 0.915315926302701 0.703703703703704 15.3 15 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00432702101732718 0.0102451762190625 0.915315926302701 0.703703703703704 15.3 15 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.24092615495394e-13 4.90590448999917e-12 0.911912291565306 0.701086956521739 15.3 15 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.15423362667966e-09 1.1236172227829e-08 0.911522656819474 0.700787401574803 15.3 15 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 6.42552270173931e-06 2.76955768295665e-05 0.910498474059003 0.7 15.3 15 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.00300928048125601 0.00732001046979026 0.910498474059003 0.7 15.3 15 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0151567474807357 0.030292207394785 0.910498474059003 0.7 15.3 15 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0151567474807357 0.030292207394785 0.910498474059003 0.7 15.3 15 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0852083876789267 0.132515339526899 0.910498474059003 0.7 15.3 15 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.34871118593185e-10 1.61278656939582e-09 0.909588885173829 0.699300699300699 15.3 15 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.61676437152406e-09 2.34247760386294e-08 0.909440984542094 0.699186991869919 15.3 15 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.47164458615085e-05 5.84958169299625e-05 0.90655692222325 0.696969696969697 15.3 15 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00209752530016384 0.00532996161095204 0.90655692222325 0.696969696969697 15.3 15 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.69597841976115e-07 1.9206596437058e-06 0.904843204033792 0.695652173913043 15.3 15 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.010383021482769 0.0219214236943328 0.904843204033792 0.695652173913043 15.3 15 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.010383021482769 0.0219214236943328 0.904843204033792 0.695652173913043 15.3 15 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 7.42734310256499e-06 3.04585280546109e-05 0.903272295693455 0.694444444444444 15.3 15 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00146489705591707 0.0038890830421082 0.903272295693455 0.694444444444444 15.3 15 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.17638851892355e-06 5.58000287476069e-06 0.902847226377835 0.694117647058824 15.3 15 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.17638851892355e-06 5.58000287476069e-06 0.902847226377835 0.694117647058824 15.3 15 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.17638851892355e-06 5.58000287476069e-06 0.902847226377835 0.694117647058824 15.3 15 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.17638851892355e-06 5.58000287476069e-06 0.902847226377835 0.694117647058824 15.3 15 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.17638851892355e-06 5.58000287476069e-06 0.902847226377835 0.694117647058824 15.3 15 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 8.37842133399518e-07 4.15417894016556e-06 0.901629982428558 0.693181818181818 15.3 15 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00714720721513473 0.0154566502540072 0.900492996322091 0.692307692307692 15.3 15 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00714720721513473 0.0154566502540072 0.900492996322091 0.692307692307692 15.3 15 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0558046470241478 0.0943111789968674 0.900492996322091 0.692307692307692 15.3 15 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0558046470241478 0.0943111789968674 0.900492996322091 0.692307692307692 15.3 15 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0558046470241478 0.0943111789968674 0.900492996322091 0.692307692307692 15.3 15 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0558046470241478 0.0943111789968674 0.900492996322091 0.692307692307692 15.3 15 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0558046470241478 0.0943111789968674 0.900492996322091 0.692307692307692 15.3 15 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0558046470241478 0.0943111789968674 0.900492996322091 0.692307692307692 15.3 15 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0558046470241478 0.0943111789968674 0.900492996322091 0.692307692307692 15.3 15 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 7.68913083936943e-05 0.000266219785509068 0.897042831585225 0.689655172413793 15.3 15 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 7.68913083936943e-05 0.000266219785509068 0.897042831585225 0.689655172413793 15.3 15 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 7.68913083936943e-05 0.000266219785509068 0.897042831585225 0.689655172413793 15.3 15 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00493923606127296 0.0115033271934393 0.897042831585225 0.689655172413793 15.3 15 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0371700254824561 0.065787246593949 0.894239572736521 0.6875 15.3 15 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0371700254824561 0.065787246593949 0.894239572736521 0.6875 15.3 15 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0371700254824561 0.065787246593949 0.894239572736521 0.6875 15.3 15 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.82216580438698e-46 8.03188387928535e-44 0.891012774138589 0.685019206145967 15.3 15 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 9.6556444404154e-06 3.88135085839297e-05 0.889960914493762 0.684210526315789 15.3 15 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00165936550646492 0.00427767593423837 0.889960914493762 0.684210526315789 15.3 15 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.7856595055783e-07 1.49022311144283e-06 0.887986149150951 0.682692307692308 15.3 15 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.67734820382294e-31 4.3607220783667e-29 0.886627727548093 0.681647940074906 15.3 15 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.61756004156086e-08 2.45132759006719e-07 0.884910694928539 0.680327868852459 15.3 15 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0116409399565353 0.0239379444481932 0.884484231943032 0.68 15.3 15 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 5.50803044631904e-10 5.89317843993383e-09 0.883817200093904 0.67948717948718 15.3 15 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 7.70344673860079e-06 3.15000135316923e-05 0.883199578011379 0.679012345679012 15.3 15 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00800282260464569 0.0172024419432187 0.882626071791891 0.678571428571429 15.3 15 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00552464567117896 0.0128038612216411 0.881127555540971 0.67741935483871 15.3 15 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 4.94737094523769e-07 2.55076407792508e-06 0.879529138206656 0.676190476190476 15.3 15 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.77563975298458e-07 9.71821295575793e-07 0.87855115917974 0.675438596491228 15.3 15 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00185171178838589 0.00472219690837476 0.877980671414039 0.675 15.3 15 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000903710380533372 0.00254146219663832 0.876566853907736 0.673913043478261 15.3 15 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000632958021294201 0.0018266863071041 0.875989785537816 0.673469387755102 15.3 15 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.59740680081859e-08 2.44933486964825e-07 0.873760803895226 0.67175572519084 15.3 15 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.59740680081859e-08 2.44933486964825e-07 0.873760803895226 0.67175572519084 15.3 15 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.90947513289641e-05 7.48535293143689e-05 0.872629640599044 0.670886075949367 15.3 15 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.10868898176883e-07 6.33600169099213e-07 0.870637941784531 0.669354838709677 15.3 15 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00292837908958253 0.00719703530997571 0.867141403865717 0.666666666666667 15.3 15 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00607868917444257 0.0136434932101448 0.867141403865717 0.666666666666667 15.3 15 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00879914722130689 0.0187162727891176 0.867141403865717 0.666666666666667 15.3 15 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0406173493551786 0.0708648469225794 0.867141403865717 0.666666666666667 15.3 15 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0406173493551786 0.0708648469225794 0.867141403865717 0.666666666666667 15.3 15 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0607594343877571 0.100887602256451 0.867141403865717 0.666666666666667 15.3 15 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.143068549996343 0.210534174399996 0.867141403865717 0.666666666666667 15.3 15 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.143068549996343 0.210534174399996 0.867141403865717 0.666666666666667 15.3 15 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.143068549996343 0.210534174399996 0.867141403865717 0.666666666666667 15.3 15 3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.143068549996343 0.210534174399996 0.867141403865717 0.666666666666667 15.3 15 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.143068549996343 0.210534174399996 0.867141403865717 0.666666666666667 15.3 15 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000996293920357164 0.00272639663205432 0.867141403865717 0.666666666666667 15.3 15 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000996293920357164 0.00272639663205432 0.867141403865717 0.666666666666667 15.3 15 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0127875796107498 0.0261823392605712 0.867141403865717 0.666666666666667 15.3 15 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0127875796107498 0.0261823392605712 0.867141403865717 0.666666666666667 15.3 15 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0186737644128122 0.0363512541168696 0.867141403865717 0.666666666666667 15.3 15 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0186737644128122 0.0363512541168696 0.867141403865717 0.666666666666667 15.3 15 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0922170109707942 0.14201818897342 0.867141403865717 0.666666666666667 15.3 15 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0922170109707942 0.14201818897342 0.867141403865717 0.666666666666667 15.3 15 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0922170109707942 0.14201818897342 0.867141403865717 0.666666666666667 15.3 15 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0922170109707942 0.14201818897342 0.867141403865717 0.666666666666667 15.3 15 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0922170109707942 0.14201818897342 0.867141403865717 0.666666666666667 15.3 15 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0274341496149365 0.0516386175953104 0.867141403865717 0.666666666666667 15.3 15 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0274341496149365 0.0516386175953104 0.867141403865717 0.666666666666667 15.3 15 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.10886444257817e-13 4.90590448999917e-12 0.861979847890326 0.662698412698413 15.3 15 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.10886444257817e-13 4.90590448999917e-12 0.861979847890326 0.662698412698413 15.3 15 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.10886444257817e-13 4.90590448999917e-12 0.861979847890326 0.662698412698413 15.3 15 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 6.95896997209127e-17 2.75072618619052e-15 0.861821517952431 0.662576687116564 15.3 15 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.1083759228618e-07 2.12589779572085e-06 0.859974945982529 0.661157024793388 15.3 15 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00318799069004309 0.00774148592479747 0.856566508696623 0.658536585365854 15.3 15 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.62821701087297e-08 1.25646463488786e-07 0.855952482525514 0.658064516129032 15.3 15 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0045806830524923 0.0107385699896154 0.855731648551695 0.657894736842105 15.3 15 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00659859477910796 0.0146715630791728 0.854753669524778 0.657142857142857 15.3 15 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00659859477910796 0.0146715630791728 0.854753669524778 0.657142857142857 15.3 15 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00659859477910796 0.0146715630791728 0.854753669524778 0.657142857142857 15.3 15 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.020129101801403 0.0388652806830346 0.85046560763753 0.653846153846154 15.3 15 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.020129101801403 0.0388652806830346 0.85046560763753 0.653846153846154 15.3 15 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00240077725602264 0.00600405278615153 0.84829050378168 0.652173913043478 15.3 15 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 4.09003203396243e-08 2.74533753977761e-07 0.847560791520362 0.651612903225806 15.3 15 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.16042162925153e-09 1.1236172227829e-08 0.846817777212614 0.651041666666667 15.3 15 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00492790407751915 0.0114957500037865 0.845462868769074 0.65 15.3 15 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.0434117734078295 0.0752435487933513 0.845462868769074 0.65 15.3 15 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0434117734078295 0.0752435487933513 0.845462868769074 0.65 15.3 15 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0434117734078295 0.0752435487933513 0.845462868769074 0.65 15.3 15 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0102067292665217 0.0216133567652685 0.84163724492849 0.647058823529412 15.3 15 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0645059493721663 0.106610877998365 0.84163724492849 0.647058823529412 15.3 15 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0645059493721663 0.106610877998365 0.84163724492849 0.647058823529412 15.3 15 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0645059493721663 0.106610877998365 0.84163724492849 0.647058823529412 15.3 15 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00257089570550382 0.00640697826432913 0.840043234994914 0.645833333333333 15.3 15 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 6.63681777855389e-06 2.76955768295665e-05 0.839550541015444 0.645454545454546 15.3 15 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0147527864033575 0.0295679085239124 0.83916910051521 0.645161290322581 15.3 15 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0969471500306202 0.148980339625888 0.83617206801337 0.642857142857143 15.3 15 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.19082006848224e-12 3.89692119681278e-11 0.83583666004385 0.642599277978339 15.3 15 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.75603325553835e-09 5.65519724860651e-08 0.833268692777213 0.640625 15.3 15 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0311765634461932 0.0573923024371706 0.832455747711089 0.64 15.3 15 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0311765634461932 0.0573923024371706 0.832455747711089 0.64 15.3 15 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0311765634461932 0.0573923024371706 0.832455747711089 0.64 15.3 15 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 8.56388416209688e-07 4.23139137592495e-06 0.830241769658665 0.638297872340426 15.3 15 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00203359994088146 0.00517676693358555 0.827725885508185 0.636363636363636 15.3 15 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0456590464826726 0.0789463221687037 0.827725885508185 0.636363636363636 15.3 15 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0456590464826726 0.0789463221687037 0.827725885508185 0.636363636363636 15.3 15 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.148073349965622 0.215641550294757 0.827725885508185 0.636363636363636 15.3 15 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.148073349965622 0.215641550294757 0.827725885508185 0.636363636363636 15.3 15 3 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.148073349965622 0.215641550294757 0.827725885508185 0.636363636363636 15.3 15 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.148073349965622 0.215641550294757 0.827725885508185 0.636363636363636 15.3 15 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.148073349965622 0.215641550294757 0.827725885508185 0.636363636363636 15.3 15 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.148073349965622 0.215641550294757 0.827725885508185 0.636363636363636 15.3 15 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.148073349965622 0.215641550294757 0.827725885508185 0.636363636363636 15.3 15 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 2.79491056634524e-25 2.4857235849433e-23 0.82735808906939 0.636080870917574 15.3 15 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00794375394914429 0.0171013038874922 0.824841823189341 0.634146341463415 15.3 15 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0113724834065978 0.0234197451339923 0.821502382609627 0.631578947368421 15.3 15 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0673110798693958 0.110860725294155 0.821502382609627 0.631578947368421 15.3 15 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0673110798693958 0.110860725294155 0.821502382609627 0.631578947368421 15.3 15 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0673110798693958 0.110860725294155 0.821502382609627 0.631578947368421 15.3 15 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.24338525374901e-57 1.53844573869494e-54 0.821237210762432 0.631375080697224 15.3 15 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0326096895255135 0.0599529563240385 0.818966881428733 0.62962962962963 15.3 15 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000837511886435307 0.00236464169523302 0.817590466501962 0.628571428571429 15.3 15 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.12610206423359e-18 9.45451011688876e-17 0.817215080612843 0.628282828282828 15.3 15 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00610224354261784 0.0136747914348743 0.81294506612411 0.625 15.3 15 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0118700954532085 0.0243739478065161 0.81294506612411 0.625 15.3 15 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0474480269539947 0.0817415767016155 0.81294506612411 0.625 15.3 15 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0474480269539947 0.0817415767016155 0.81294506612411 0.625 15.3 15 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0234509935825391 0.0443760157818526 0.81294506612411 0.625 15.3 15 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.23182148554565 0.307438931902572 0.81294506612411 0.625 15.3 15 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.87353169028524e-16 1.89955354438088e-14 0.810757769982072 0.623318385650224 15.3 15 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00234168207032507 0.00591132127354997 0.810279672464687 0.622950819672131 15.3 15 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0337980597966737 0.0618183021730933 0.807338548426702 0.620689655172414 15.3 15 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.000143263459222448 0.000484237298036919 0.806441505595117 0.62 15.3 15 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.2189606730513e-19 1.08882104750069e-17 0.806395946502094 0.619964973730298 15.3 15 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 7.10174777255802e-33 1.01057870803501e-30 0.805946740229548 0.61961961961962 15.3 15 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00465347061164309 0.0108912642769212 0.804076574493665 0.618181818181818 15.3 15 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 2.82282606672615e-06 1.2752004739528e-05 0.803624676830967 0.617834394904459 15.3 15 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000703679716310807 0.00201882305707717 0.802908707283072 0.617283950617284 15.3 15 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0488525020778574 0.0840593838655274 0.80043821895297 0.615384615384615 15.3 15 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.150476793285428 0.218498445760372 0.80043821895297 0.615384615384615 15.3 15 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.150476793285428 0.218498445760372 0.80043821895297 0.615384615384615 15.3 15 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00481003770944688 0.0112392178334038 0.798682871981582 0.614035087719298 15.3 15 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00925604389997103 0.0196294343810116 0.796354350488924 0.612244897959184 15.3 15 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.10204517797029 0.156308168193458 0.794879620210241 0.611111111111111 15.3 15 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0026760972857657 0.00664587510932737 0.791737803529568 0.608695652173913 15.3 15 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0130576330619941 0.026629048163806 0.791737803529568 0.608695652173913 15.3 15 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0708511654423214 0.116556310317252 0.791737803529568 0.608695652173913 15.3 15 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000234769490106307 0.000750734796452305 0.790152213802873 0.607476635514019 15.3 15 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0499335353586224 0.085505921558748 0.78971806423485 0.607142857142857 15.3 15 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0050855829498463 0.0118248113359988 0.7889565231893 0.60655737704918 15.3 15 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0355595764659695 0.0633903795169225 0.788310367150652 0.606060606060606 15.3 15 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0355595764659695 0.0633903795169225 0.788310367150652 0.606060606060606 15.3 15 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.013362242245098 0.0271635295925348 0.785846897253306 0.604166666666667 15.3 15 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00520539252798646 0.0120836436661089 0.784556508259458 0.603174603174603 15.3 15 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0718552222156966 0.117935387788854 0.780427263479146 0.6 15.3 15 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0507416975953042 0.0867853794208148 0.780427263479145 0.6 15.3 15 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.103160039561745 0.157602697491658 0.780427263479145 0.6 15.3 15 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.151228723494915 0.218920115496708 0.780427263479145 0.6 15.3 15 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.229858793472467 0.307438931902572 0.780427263479145 0.6 15.3 15 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.229858793472467 0.307438931902572 0.780427263479145 0.6 15.3 15 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0187764193293898 0.0365011539695652 0.780427263479145 0.6 15.3 15 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0138530334886429 0.0280810066301122 0.775424524610689 0.596153846153846 15.3 15 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0513189883594796 0.0876673714712359 0.772297812817904 0.59375 15.3 15 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0724784112449032 0.118684440968351 0.770792358991749 0.592592592592593 15.3 15 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.4231154644444e-12 2.59627346910817e-11 0.769323623551597 0.591463414634146 15.3 15 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.103632384588158 0.1580588245112 0.768602607971886 0.590909090909091 15.3 15 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.150888210931486 0.218649617266298 0.765124768116809 0.588235294117647 15.3 15 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.150888210931486 0.218649617266298 0.765124768116809 0.588235294117647 15.3 15 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.226272224558382 0.306652738615788 0.758748728382503 0.583333333333333 15.3 15 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.226272224558382 0.306652738615788 0.758748728382503 0.583333333333333 15.3 15 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.226272224558382 0.306652738615788 0.758748728382503 0.583333333333333 15.3 15 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.226272224558382 0.306652738615788 0.758748728382503 0.583333333333333 15.3 15 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.226272224558382 0.306652738615788 0.758748728382503 0.583333333333333 15.3 15 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0197757343769091 0.0382868979841384 0.756777952464626 0.581818181818182 15.3 15 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0374157107162175 0.0661398215517734 0.756227968487544 0.581395348837209 15.3 15 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 5.8582355644565e-06 2.55713779393301e-05 0.753631477608617 0.579399141630901 15.3 15 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.103222567858205 0.157602697491658 0.750410830268409 0.576923076923077 15.3 15 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.00587964446290197 0.0133653898893123 0.749822272754473 0.576470588235294 15.3 15 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.00587964446290197 0.0133653898893123 0.749822272754473 0.576470588235294 15.3 15 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.102538245759945 0.156894541630539 0.743264060456329 0.571428571428571 15.3 15 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.221849650958506 0.30209765867364 0.743264060456329 0.571428571428571 15.3 15 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0723899826768038 0.11867620431923 0.743264060456329 0.571428571428571 15.3 15 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.148206209549032 0.215641550294757 0.743264060456329 0.571428571428571 15.3 15 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.148206209549032 0.215641550294757 0.743264060456329 0.571428571428571 15.3 15 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.08828927876657e-05 4.3501001227102e-05 0.739620609179582 0.568627450980392 15.3 15 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0107444461717095 0.0226173770744714 0.738676010700426 0.567901234567901 15.3 15 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.10162730100164 0.155835829014368 0.73707019328586 0.566666666666667 15.3 15 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.146247969477746 0.214768689955452 0.735185103277456 0.565217391304348 15.3 15 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0713597707155747 0.117257452342105 0.733735034040222 0.564102564102564 15.3 15 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.100539767346578 0.154334508019612 0.731650559511699 0.5625 15.3 15 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.216997647549902 0.301256246305864 0.731650559511699 0.5625 15.3 15 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.216997647549902 0.301256246305864 0.731650559511699 0.5625 15.3 15 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.216997647549902 0.301256246305864 0.731650559511699 0.5625 15.3 15 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.216997647549902 0.301256246305864 0.731650559511699 0.5625 15.3 15 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.144037806557248 0.211741527614632 0.728398779247203 0.56 15.3 15 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0104503177212483 0.0220308179516093 0.727279887113182 0.559139784946237 15.3 15 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.211942002132981 0.295390273296015 0.722617836554764 0.555555555555556 15.3 15 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.342762654982283 0.441403853429673 0.722617836554764 0.555555555555556 15.3 15 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.342762654982283 0.441403853429673 0.722617836554764 0.555555555555556 15.3 15 3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.342762654982283 0.441403853429673 0.722617836554764 0.555555555555556 15.3 15 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.342762654982283 0.441403853429673 0.722617836554764 0.555555555555556 15.3 15 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.342762654982283 0.441403853429673 0.722617836554764 0.555555555555556 15.3 15 3 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.342762654982283 0.441403853429673 0.722617836554764 0.555555555555556 15.3 15 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000518268451699904 0.00153007470284017 0.7196833478784 0.553299492385787 15.3 15 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0136336155853604 0.0276756561739912 0.71954286703751 0.553191489361702 15.3 15 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0175700999876717 0.0342966423627665 0.71196873159501 0.547368421052632 15.3 15 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0014737852297501 0.00389728129916178 0.710118501003547 0.545945945945946 15.3 15 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.133939374190237 0.198330623800944 0.709479330435587 0.545454545454545 15.3 15 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.133939374190237 0.198330623800944 0.709479330435587 0.545454545454545 15.3 15 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.133939374190237 0.198330623800944 0.709479330435587 0.545454545454545 15.3 15 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0236395489469411 0.0446734105597571 0.709479330435587 0.545454545454545 15.3 15 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.328001325680681 0.425863035076286 0.709479330435587 0.545454545454545 15.3 15 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0904423774528795 0.140042984891673 0.7069087531514 0.543478260869565 15.3 15 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.125981907957492 0.18910575424421 0.700383441583848 0.538461538461538 15.3 15 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.191655585039463 0.26737833089329 0.700383441583848 0.538461538461538 15.3 15 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.191655585039463 0.26737833089329 0.700383441583848 0.538461538461538 15.3 15 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.314700227710161 0.412735874683465 0.700383441583848 0.538461538461538 15.3 15 3 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.314700227710161 0.412735874683465 0.700383441583848 0.538461538461538 15.3 15 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.314700227710161 0.412735874683465 0.700383441583848 0.538461538461538 15.3 15 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.186784899622779 0.264068083960655 0.696810056677808 0.535714285714286 15.3 15 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.000926730431661567 0.00260105996894361 0.693713123092574 0.533333333333333 15.3 15 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.18203063103597 0.263241451183116 0.693713123092574 0.533333333333333 15.3 15 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.302559282345466 0.398281090451062 0.693713123092574 0.533333333333333 15.3 15 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.302559282345466 0.398281090451062 0.693713123092574 0.533333333333333 15.3 15 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.141187188942872 0.208845498820901 0.676370295015259 0.52 15.3 15 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.245504777332144 0.324979812226643 0.67444331411778 0.518518518518518 15.3 15 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.245504777332144 0.324979812226643 0.67444331411778 0.518518518518518 15.3 15 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0272576114152013 0.0514424151774953 0.666218395652929 0.51219512195122 15.3 15 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0875451144842221 0.136000761911624 0.664808409630383 0.511111111111111 15.3 15 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0746203822487779 0.12144486362985 0.662862900070428 0.509615384615385 15.3 15 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0472453345900782 0.081589940681652 0.654395531488724 0.503105590062112 15.3 15 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0549627220108797 0.093667010085607 0.650356052899288 0.5 15.3 15 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.304224655041509 0.400103220077696 0.650356052899288 0.5 15.3 15 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.340872589757269 0.441366419676609 0.650356052899288 0.5 15.3 15 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.340872589757269 0.441366419676609 0.650356052899288 0.5 15.3 15 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.388120917141028 0.485321674070021 0.650356052899288 0.5 15.3 15 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.407550804461818 0.502116705410534 0.650356052899288 0.5 15.3 15 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.407550804461818 0.502116705410534 0.650356052899288 0.5 15.3 15 3 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.429730426802981 0.526386516042117 0.650356052899288 0.5 15.3 15 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.455666516492099 0.548573141259101 0.650356052899288 0.5 15.3 15 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.455666516492099 0.548573141259101 0.650356052899288 0.5 15.3 15 3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.455666516492099 0.548573141259101 0.650356052899288 0.5 15.3 15 3 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.455666516492099 0.548573141259101 0.650356052899288 0.5 15.3 15 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.455666516492099 0.548573141259101 0.650356052899288 0.5 15.3 15 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.455666516492099 0.548573141259101 0.650356052899288 0.5 15.3 15 3 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.455666516492099 0.548573141259101 0.650356052899288 0.5 15.3 15 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0635871676366877 0.105459836301873 0.646366138464323 0.496932515337423 15.3 15 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0895769623779825 0.138854049524912 0.63808518397666 0.490566037735849 15.3 15 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0895769623779825 0.138854049524912 0.63808518397666 0.490566037735849 15.3 15 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0937122166917342 0.144164847948473 0.63776851639156 0.490322580645161 15.3 15 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.278377586397759 0.367468743454556 0.635903696168193 0.488888888888889 15.3 15 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.340193020041062 0.441289578412426 0.630648293720522 0.484848484848485 15.3 15 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.248383220480005 0.328484500690564 0.630032426246185 0.484375 15.3 15 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.287400897090254 0.379028245189464 0.626268791680796 0.481481481481481 15.3 15 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.26581986812086 0.35121789446238 0.603902049120767 0.464285714285714 15.3 15 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.528327740311112 0.628078842491823 0.600328664214727 0.461538461538462 15.3 15 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.485159161984848 0.582932404510408 0.596159715157681 0.458333333333333 15.3 15 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.31766099386976 0.416235353845919 0.595396386457094 0.457746478873239 15.3 15 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.562054175501614 0.662637192824189 0.591232775362989 0.454545454545455 15.3 15 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.366757588558379 0.468488373894589 0.588643434740961 0.452554744525547 15.3 15 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.366757588558379 0.468488373894589 0.588643434740961 0.452554744525547 15.3 15 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0516456428209681 0.0881196039978868 0.588175669305015 0.45219512195122 15.3 15 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.530573012533573 0.630221533251481 0.585320447609359 0.45 15.3 15 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.499138211548471 0.596868634481911 0.575725030435435 0.442622950819672 15.3 15 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.471727421608794 0.567428673668059 0.573843576087607 0.441176470588235 15.3 15 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.585983084558979 0.679034144403442 0.569061546286877 0.4375 15.3 15 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.585983084558979 0.679034144403442 0.569061546286877 0.4375 15.3 15 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.575494568382382 0.677360439047254 0.563641912512716 0.433333333333333 15.3 15 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.573486274846459 0.675555438002079 0.559800146799387 0.430379746835443 15.3 15 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.588499239538932 0.681394969783483 0.557448045342247 0.428571428571429 15.3 15 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.618910442198083 0.709105925320348 0.557448045342247 0.428571428571429 15.3 15 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.618910442198083 0.709105925320348 0.557448045342247 0.428571428571429 15.3 15 3 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.618910442198083 0.709105925320348 0.557448045342247 0.428571428571429 15.3 15 3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.618910442198083 0.709105925320348 0.557448045342247 0.428571428571429 15.3 15 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.618910442198083 0.709105925320348 0.557448045342247 0.428571428571429 15.3 15 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.618910442198083 0.709105925320348 0.557448045342247 0.428571428571429 15.3 15 3 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.618910442198083 0.709105925320348 0.557448045342247 0.428571428571429 15.3 15 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.65657113885778 0.748039015688247 0.541963377416073 0.416666666666667 15.3 15 3 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.65657113885778 0.748039015688247 0.541963377416073 0.416666666666667 15.3 15 3 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.65657113885778 0.748039015688247 0.541963377416073 0.416666666666667 15.3 15 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.695025317535709 0.781217240800406 0.538678750886279 0.414141414141414 15.3 15 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.826786653573998 0.897419838318687 0.536376126102506 0.412371134020619 15.3 15 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.825457613133961 0.896661208770707 0.527477720323846 0.405529953917051 15.3 15 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.698016063527136 0.783959635674124 0.52731571856699 0.405405405405405 15.3 15 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.739360818653678 0.823892282650105 0.526870726399423 0.40506329113924 15.3 15 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.867494170163147 0.940170757153205 0.524930242697282 0.403571428571429 15.3 15 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.732700834681816 0.817110727078546 0.505832485588335 0.388888888888889 15.3 15 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.761330505460039 0.841781903084409 0.503501460309126 0.387096774193548 15.3 15 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.783708393385031 0.865851742070574 0.497331099275926 0.382352941176471 15.3 15 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.967052805238034 1 0.480376629982429 0.369318181818182 15.3 15 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.790715604028701 0.872238995761892 0.479209723188949 0.368421052631579 15.3 15 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.790715604028701 0.872238995761892 0.479209723188949 0.368421052631579 15.3 15 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.876913792685555 0.949415841668128 0.47047033613991 0.361702127659574 15.3 15 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.802174830033539 0.882826591753849 0.464540037785206 0.357142857142857 15.3 15 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.802174830033539 0.882826591753849 0.464540037785206 0.357142857142857 15.3 15 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.802174830033539 0.882826591753849 0.464540037785206 0.357142857142857 15.3 15 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.838649111901065 0.909601894996353 0.455249237029501 0.35 15.3 15 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.877358982286429 0.949415841668128 0.433570701932859 0.333333333333333 15.3 15 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.92700380688688 0.997059887789321 0.419584550257605 0.32258064516129 15.3 15 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.92700380688688 0.997059887789321 0.419584550257605 0.32258064516129 15.3 15 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999782047805751 1 0.405598398582352 0.311827956989247 15.3 15 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.988596844774135 1 0.403037553909418 0.309859154929577 15.3 15 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.927693107120914 0.997059887789321 0.390213631739573 0.3 15.3 15 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.955153257393642 1 0.390213631739573 0.3 15.3 15 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.966668941691862 1 0.377626095231845 0.290322580645161 15.3 15 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.965096314576519 1 0.371632030228165 0.285714285714286 15.3 15 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.992148595382299 1 0.368126067678842 0.283018867924528 15.3 15 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.963740089443409 1 0.364199389623601 0.28 15.3 15 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.993680808699215 1 0.352276195320448 0.270833333333333 15.3 15 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.990733550123291 1 0.342292659420678 0.263157894736842 15.3 15 3 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.973690498115932 1 0.339316201512672 0.260869565217391 15.3 15 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.338556467504247 0.260285474391268 15.3 15 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.99063098131443 1 0.334468827205348 0.257142857142857 15.3 15 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.292836631413965 0.225135623869801 15.3 15 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999998881549573 1 0.289047134621906 0.222222222222222 15.3 15 3 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999594222616121 1 0.276747256552888 0.212765957446809 15.3 15 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999720426296563 1 0.270981688708037 0.208333333333333 15.3 15 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999996644522 1 0.202332994235334 0.155555555555556 15.3 15 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0188813047615922 0.0145161290322581 15.3 15 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 5.99968193061095e-08 3.18565201017141e-07 0.810438680755684 1 15.1 15 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.0869072652553e-07 5.50416027921103e-07 0.810438680755684 1 15.1 15 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.0869072652553e-07 5.50416027921103e-07 0.810438680755684 1 15.1 15 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.56689091501396e-07 1.70325025908217e-06 0.810438680755684 1 15.1 15 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 6.46134455589256e-07 2.99494895864336e-06 0.810438680755684 1 15.1 15 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 6.46134455589256e-07 2.99494895864336e-06 0.810438680755684 1 15.1 15 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 6.46134455589256e-07 2.99494895864336e-06 0.810438680755684 1 15.1 15 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 1.17043035954749e-06 5.28737270360662e-06 0.810438680755684 1 15.1 15 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.17043035954749e-06 5.28737270360662e-06 0.810438680755684 1 15.1 15 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 2.12010739738081e-06 9.14216008022087e-06 0.810438680755684 1 15.1 15 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 3.84025223558269e-06 1.60254514112439e-05 0.810438680755684 1 15.1 15 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 3.84025223558269e-06 1.60254514112439e-05 0.810438680755684 1 15.1 15 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 3.84025223558269e-06 1.60254514112439e-05 0.810438680755684 1 15.1 15 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 6.95586664147857e-06 2.71183513173261e-05 0.810438680755684 1 15.1 15 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 6.95586664147857e-06 2.71183513173261e-05 0.810438680755684 1 15.1 15 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 6.95586664147857e-06 2.71183513173261e-05 0.810438680755684 1 15.1 15 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 6.95586664147857e-06 2.71183513173261e-05 0.810438680755684 1 15.1 15 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 6.95586664147857e-06 2.71183513173261e-05 0.810438680755684 1 15.1 15 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 6.95586664147857e-06 2.71183513173261e-05 0.810438680755684 1 15.1 15 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 6.95586664147857e-06 2.71183513173261e-05 0.810438680755684 1 15.1 15 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.000245517257185478 0.000717394367505 0.810438680755684 1 15.1 15 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.000805210035022177 0.00213771246238164 0.810438680755684 1 15.1 15 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00145816670677135 0.00363392508535137 0.810438680755684 1 15.1 15 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00145816670677135 0.00363392508535137 0.810438680755684 1 15.1 15 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00145816670677135 0.00363392508535137 0.810438680755684 1 15.1 15 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00145816670677135 0.00363392508535137 0.810438680755684 1 15.1 15 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00145816670677135 0.00363392508535137 0.810438680755684 1 15.1 15 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00145816670677135 0.00363392508535137 0.810438680755684 1 15.1 15 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00145816670677135 0.00363392508535137 0.810438680755684 1 15.1 15 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00264055241848802 0.0062005051014991 0.810438680755684 1 15.1 15 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0156781690076787 0.0301486952674686 0.810438680755684 1 15.1 15 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_217410.1 ACTIVATION OF TRKA RECEPTORS 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0283884335042946 0.0502447025828498 0.810438680755684 1 15.1 15 1 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%REACT_215995.1 NOSTRIN MEDIATED ENOS TRAFFICKING 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605564 MUSCARINIC ACETYLCHOLINE RECEPTORS 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 G2 PHASE%REACTOME%REACT_227891.1 G2 PHASE 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_199058.2 GRB7 EVENTS IN ERBB2 SIGNALING 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%REACT_221082.1 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%REACT_209347.1 NGF-INDEPENDANT TRKA ACTIVATION 0.0514016588924448 0.083498356853823 0.810438680755684 1 15.1 15 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.91477889296864e-14 1.27788706034992e-12 0.810438680755684 1 15.1 15 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.91477889296864e-14 1.27788706034992e-12 0.810438680755684 1 15.1 15 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.82796762788401e-08 1.00821625367401e-07 0.810438680755684 1 15.1 15 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 3.3117196401266e-08 1.79869352973288e-07 0.810438680755684 1 15.1 15 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.96900291137368e-07 9.79682217791869e-07 0.810438680755684 1 15.1 15 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 1.96900291137368e-07 9.79682217791869e-07 0.810438680755684 1 15.1 15 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 1.96900291137368e-07 9.79682217791869e-07 0.810438680755684 1 15.1 15 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 1.25988919535943e-05 4.7808595333239e-05 0.810438680755684 1 15.1 15 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 1.25988919535943e-05 4.7808595333239e-05 0.810438680755684 1 15.1 15 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 1.25988919535943e-05 4.7808595333239e-05 0.810438680755684 1 15.1 15 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 1.25988919535943e-05 4.7808595333239e-05 0.810438680755684 1 15.1 15 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 2.28193392403081e-05 8.41241444014466e-05 0.810438680755684 1 15.1 15 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 2.28193392403081e-05 8.41241444014466e-05 0.810438680755684 1 15.1 15 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 2.28193392403081e-05 8.41241444014466e-05 0.810438680755684 1 15.1 15 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 2.28193392403081e-05 8.41241444014466e-05 0.810438680755684 1 15.1 15 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 2.28193392403081e-05 8.41241444014466e-05 0.810438680755684 1 15.1 15 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 7.48537084585099e-05 0.000243189103051278 0.810438680755684 1 15.1 15 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000135566650649982 0.000417498050518227 0.810438680755684 1 15.1 15 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000135566650649982 0.000417498050518227 0.810438680755684 1 15.1 15 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000135566650649982 0.000417498050518227 0.810438680755684 1 15.1 15 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000135566650649982 0.000417498050518227 0.810438680755684 1 15.1 15 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000135566650649982 0.000417498050518227 0.810438680755684 1 15.1 15 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000135566650649982 0.000417498050518227 0.810438680755684 1 15.1 15 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000135566650649982 0.000417498050518227 0.810438680755684 1 15.1 15 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000135566650649982 0.000417498050518227 0.810438680755684 1 15.1 15 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000444632080556301 0.00123335565425266 0.810438680755684 1 15.1 15 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000444632080556301 0.00123335565425266 0.810438680755684 1 15.1 15 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.000444632080556301 0.00123335565425266 0.810438680755684 1 15.1 15 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.000444632080556301 0.00123335565425266 0.810438680755684 1 15.1 15 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000444632080556301 0.00123335565425266 0.810438680755684 1 15.1 15 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000444632080556301 0.00123335565425266 0.810438680755684 1 15.1 15 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.000444632080556301 0.00123335565425266 0.810438680755684 1 15.1 15 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00478158659154366 0.0105328138076883 0.810438680755684 1 15.1 15 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.00865842449753309 0.0177279684316397 0.810438680755684 1 15.1 15 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 4.13298080028378e-05 0.00014240270408726 0.810438680755683 1 15.1 15 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.64704631083695e-11 1.81685806226432e-10 0.793554541573274 0.979166666666667 15.1 15 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 8.85235460077633e-09 5.50848727530514e-08 0.788534932627152 0.972972972972973 15.1 15 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 4.53182757170306e-16 1.13136677798832e-14 0.787926495179137 0.972222222222222 15.1 15 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.56200866836062e-08 8.68257162139516e-08 0.787926495179137 0.972222222222222 15.1 15 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.56200866836062e-08 8.68257162139516e-08 0.787926495179137 0.972222222222222 15.1 15 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.56200866836062e-08 8.68257162139516e-08 0.787926495179137 0.972222222222222 15.1 15 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 4.85225752831716e-08 2.61544032681641e-07 0.786602248968752 0.970588235294118 15.1 15 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 8.54167433324477e-08 4.41992820952993e-07 0.785879932853996 0.96969696969697 15.1 15 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 8.54167433324477e-08 4.41992820952993e-07 0.785879932853996 0.96969696969697 15.1 15 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 8.54167433324477e-08 4.41992820952993e-07 0.785879932853996 0.96969696969697 15.1 15 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.19405508071026e-14 8.06505456736581e-13 0.785112471982068 0.96875 15.1 15 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 2.63982600664099e-07 1.28207249401028e-06 0.7842954975055 0.967741935483871 15.1 15 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 8.12626260641733e-07 3.71822240801667e-06 0.782492519350315 0.96551724137931 15.1 15 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 1.42342622144989e-06 6.21329912000978e-06 0.781494442157266 0.964285714285714 15.1 15 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.42342622144989e-06 6.21329912000978e-06 0.781494442157266 0.964285714285714 15.1 15 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 1.42342622144989e-06 6.21329912000978e-06 0.781494442157266 0.964285714285714 15.1 15 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 2.49034897104515e-06 1.05784077187978e-05 0.780422433320288 0.962962962962963 15.1 15 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 2.49034897104515e-06 1.05784077187978e-05 0.780422433320288 0.962962962962963 15.1 15 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 4.35140910060212e-06 1.78961131507422e-05 0.77926796226508 0.961538461538462 15.1 15 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 4.35140910060212e-06 1.78961131507422e-05 0.77926796226508 0.961538461538462 15.1 15 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.35140910060212e-06 1.78961131507422e-05 0.77926796226508 0.961538461538462 15.1 15 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 7.59282319369791e-06 2.9520730613749e-05 0.778021133525456 0.96 15.1 15 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.85631620480814e-10 1.79696459825985e-09 0.777359550928921 0.959183673469388 15.1 15 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 1.3229236150587e-05 5.00670293677799e-05 0.776670402390863 0.958333333333333 15.1 15 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 5.61695288342652e-10 4.70171997242114e-09 0.775951928383101 0.957446808510638 15.1 15 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 9.75769462847637e-10 7.01272699814236e-09 0.775202216375002 0.956521739130435 15.1 15 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 2.30130022297136e-05 8.41838102130656e-05 0.775202216375002 0.956521739130435 15.1 15 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 2.30130022297136e-05 8.41838102130656e-05 0.775202216375002 0.956521739130435 15.1 15 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 2.30130022297136e-05 8.41838102130656e-05 0.775202216375002 0.956521739130435 15.1 15 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.6935063779618e-09 1.16418336997084e-08 0.774419183833209 0.955555555555556 15.1 15 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.6935063779618e-09 1.16418336997084e-08 0.774419183833209 0.955555555555556 15.1 15 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.78705883531536e-42 2.82553858072639e-40 0.774096139017761 0.955156950672646 15.1 15 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 2.93631171330096e-09 1.96167679250106e-08 0.773600558903153 0.954545454545455 15.1 15 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.93631171330096e-09 1.96167679250106e-08 0.773600558903153 0.954545454545455 15.1 15 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 3.99632938378225e-05 0.000140761799829756 0.773600558903153 0.954545454545455 15.1 15 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 5.08597874784498e-09 3.35062396212195e-08 0.772743858394954 0.953488372093023 15.1 15 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 5.08597874784498e-09 3.35062396212195e-08 0.772743858394954 0.953488372093023 15.1 15 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 8.80002803143056e-09 5.50848727530514e-08 0.771846362624461 0.952380952380952 15.1 15 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 6.92681547593961e-05 0.000233022657736692 0.771846362624461 0.952380952380952 15.1 15 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 6.92681547593961e-05 0.000233022657736692 0.771846362624461 0.952380952380952 15.1 15 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 6.92681547593961e-05 0.000233022657736692 0.771846362624461 0.952380952380952 15.1 15 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.24470346496206e-12 1.82599281509383e-11 0.77184636262446 0.952380952380952 15.1 15 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.52093047091469e-08 8.55448245103402e-08 0.77090508657248 0.951219512195122 15.1 15 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.52093047091469e-08 8.55448245103402e-08 0.77090508657248 0.951219512195122 15.1 15 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.52093047091469e-08 8.55448245103402e-08 0.77090508657248 0.951219512195122 15.1 15 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.52093047091469e-08 8.55448245103402e-08 0.77090508657248 0.951219512195122 15.1 15 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.91847020951422e-30 7.51198873875915e-28 0.7699167467179 0.95 15.1 15 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000119816372883792 0.000379729841010326 0.7699167467179 0.95 15.1 15 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000119816372883792 0.000379729841010326 0.7699167467179 0.95 15.1 15 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000119816372883792 0.000379729841010326 0.7699167467179 0.95 15.1 15 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000119816372883792 0.000379729841010326 0.7699167467179 0.95 15.1 15 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 6.41014456050714e-12 7.66524009210223e-11 0.769916746717899 0.95 15.1 15 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 6.41014456050714e-12 7.66524009210223e-11 0.769916746717899 0.95 15.1 15 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 6.41014456050714e-12 7.66524009210223e-11 0.769916746717899 0.95 15.1 15 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 6.41014456050714e-12 7.66524009210223e-11 0.769916746717899 0.95 15.1 15 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 6.41014456050714e-12 7.66524009210223e-11 0.769916746717899 0.95 15.1 15 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 6.41014456050714e-12 7.66524009210223e-11 0.769916746717899 0.95 15.1 15 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 6.41014456050714e-12 7.66524009210223e-11 0.769916746717899 0.95 15.1 15 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000206787390401156 0.000623428933349249 0.76778401334749 0.947368421052632 15.1 15 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.000206787390401156 0.000623428933349249 0.76778401334749 0.947368421052632 15.1 15 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.63274809582336e-11 5.8936768679093e-10 0.767022322858058 0.946428571428571 15.1 15 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.34055398133127e-07 6.76456849444823e-07 0.76663118449862 0.945945945945946 15.1 15 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 2.30201771585308e-07 1.13348484763285e-06 0.76541430960259 0.944444444444444 15.1 15 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.30201771585308e-07 1.13348484763285e-06 0.76541430960259 0.944444444444444 15.1 15 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000356007776965843 0.00101319813324479 0.76541430960259 0.944444444444444 15.1 15 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000356007776965843 0.00101319813324479 0.76541430960259 0.944444444444444 15.1 15 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 8.33092280204241e-16 2.04394881850109e-14 0.763320152804772 0.941860465116279 15.1 15 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.42446895879919e-15 3.37836554728541e-14 0.76276581718182 0.941176470588235 15.1 15 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000611236115749267 0.00166626243814408 0.76276581718182 0.941176470588235 15.1 15 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.83945862565244e-12 2.61754962430343e-11 0.762054281904598 0.940298507462687 15.1 15 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.35385743116972e-12 6.8022670754951e-11 0.760565531170718 0.938461538461538 15.1 15 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.05860662678007e-14 4.30793710280595e-13 0.759786263208454 0.9375 15.1 15 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.97024888146685e-06 8.52177555722591e-06 0.759786263208453 0.9375 15.1 15 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.00104626078352206 0.0026777501707768 0.759786263208453 0.9375 15.1 15 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00104626078352206 0.0026777501707768 0.759786263208453 0.9375 15.1 15 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00104626078352206 0.0026777501707768 0.759786263208453 0.9375 15.1 15 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00104626078352206 0.0026777501707768 0.759786263208453 0.9375 15.1 15 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.55221511444922e-11 1.72562664676659e-10 0.758982256580719 0.936507936507937 15.1 15 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.19810688279314e-08 7.31719353740186e-08 0.757583984184661 0.934782608695652 15.1 15 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.54750047053954e-18 5.37095895018966e-17 0.75741932780905 0.934579439252336 15.1 15 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 5.70171999030336e-06 2.29196258367279e-05 0.756409435371971 0.933333333333333 15.1 15 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00178482574868242 0.00436392962263761 0.756409435371971 0.933333333333333 15.1 15 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00178482574868242 0.00436392962263761 0.756409435371971 0.933333333333333 15.1 15 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00178482574868242 0.00436392962263761 0.756409435371971 0.933333333333333 15.1 15 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00178482574868242 0.00436392962263761 0.756409435371971 0.933333333333333 15.1 15 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00178482574868242 0.00436392962263761 0.756409435371971 0.933333333333333 15.1 15 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00178482574868242 0.00436392962263761 0.756409435371971 0.933333333333333 15.1 15 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00178482574868242 0.00436392962263761 0.756409435371971 0.933333333333333 15.1 15 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00178482574868242 0.00436392962263761 0.756409435371971 0.933333333333333 15.1 15 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 9.66922569236007e-06 3.73894243484467e-05 0.754546357944947 0.931034482758621 15.1 15 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.41410113423923e-12 2.05333256532901e-11 0.754158216814317 0.930555555555556 15.1 15 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 5.83206851459051e-08 3.10825224579112e-07 0.753896447214589 0.930232558139535 15.1 15 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.42754978196958e-44 1.14330041746784e-41 0.75382715526172 0.930147058823529 15.1 15 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.04497282455233e-16 2.75369690618141e-15 0.753134935651746 0.929292929292929 15.1 15 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 1.63603447157835e-05 6.15893400279364e-05 0.752550203558849 0.928571428571429 15.1 15 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00303312478437702 0.00698403975431795 0.752550203558849 0.928571428571429 15.1 15 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00303312478437702 0.00698403975431795 0.752550203558849 0.928571428571429 15.1 15 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00303312478437702 0.00698403975431795 0.752550203558849 0.928571428571429 15.1 15 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00303312478437702 0.00698403975431795 0.752550203558849 0.928571428571429 15.1 15 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00303312478437702 0.00698403975431795 0.752550203558849 0.928571428571429 15.1 15 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 6.7986903444108e-12 7.99548459512113e-11 0.751711240121214 0.927536231884058 15.1 15 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 6.7986903444108e-12 7.99548459512113e-11 0.751711240121214 0.927536231884058 15.1 15 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 7.53693603208576e-14 1.37500768893052e-12 0.751138289480878 0.926829268292683 15.1 15 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.76678879346678e-09 1.20872137168425e-08 0.750406185884892 0.925925925925926 15.1 15 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 2.76146607200642e-05 9.84853689339635e-05 0.750406185884892 0.925925925925926 15.1 15 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 3.03659288272934e-19 1.13712412424312e-17 0.749144999017859 0.92436974789916 15.1 15 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.58214836982671e-13 5.72741250591394e-12 0.748886375888163 0.924050632911392 15.1 15 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 8.51855464805245e-27 6.06095163208932e-25 0.748463958109661 0.923529411764706 15.1 15 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 9.69966066636706e-29 8.11918654602372e-27 0.748437907364538 0.923497267759563 15.1 15 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.43010696949046e-26 9.25019189811329e-25 0.748097243774477 0.923076923076923 15.1 15 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00513214548861268 0.0111838331244959 0.748097243774477 0.923076923076923 15.1 15 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00513214548861268 0.0111838331244959 0.748097243774477 0.923076923076923 15.1 15 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00513214548861268 0.0111838331244959 0.748097243774477 0.923076923076923 15.1 15 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00513214548861268 0.0111838331244959 0.748097243774477 0.923076923076923 15.1 15 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00513214548861268 0.0111838331244959 0.748097243774477 0.923076923076923 15.1 15 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00513214548861268 0.0111838331244959 0.748097243774477 0.923076923076923 15.1 15 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00513214548861268 0.0111838331244959 0.748097243774477 0.923076923076923 15.1 15 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.68709167193071e-12 2.42498126177516e-11 0.746456679643393 0.921052631578947 15.1 15 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.52447766022083e-10 1.527698387672e-09 0.746118150536978 0.920634920634921 15.1 15 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.1672976179835e-25 1.95959326538718e-23 0.745802466953083 0.920245398773006 15.1 15 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 7.80479851548115e-05 0.000251841911281852 0.745603586295229 0.92 15.1 15 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 7.80479851548115e-05 0.000251841911281852 0.745603586295229 0.92 15.1 15 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.8218804680848e-12 3.75283729540624e-11 0.745603586295229 0.92 15.1 15 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.8218804680848e-12 3.75283729540624e-11 0.745603586295229 0.92 15.1 15 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.8218804680848e-12 3.75283729540624e-11 0.745603586295229 0.92 15.1 15 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.8218804680848e-12 3.75283729540624e-11 0.745603586295229 0.92 15.1 15 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.8218804680848e-12 3.75283729540624e-11 0.745603586295229 0.92 15.1 15 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 2.54888434495599e-10 2.41977577923947e-09 0.745080722630225 0.919354838709677 15.1 15 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.71467900499634e-12 6.15503506799064e-11 0.744727436370088 0.918918918918919 15.1 15 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.71467900499634e-12 6.15503506799064e-11 0.744727436370088 0.918918918918919 15.1 15 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.31986067070999e-06 5.8620471678919e-06 0.744727436370088 0.918918918918919 15.1 15 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.31986067070999e-06 5.8620471678919e-06 0.744727436370088 0.918918918918919 15.1 15 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.47114469377766e-24 1.40657555969824e-22 0.74417639868132 0.918238993710692 15.1 15 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 4.25592870716305e-10 3.80247785008387e-09 0.744009280693742 0.918032786885246 15.1 15 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.25592870716305e-10 3.80247785008387e-09 0.744009280693742 0.918032786885246 15.1 15 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 4.25592870716305e-10 3.80247785008387e-09 0.744009280693742 0.918032786885246 15.1 15 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 7.86803264654711e-12 9.10261012685897e-11 0.743827282337408 0.917808219178082 15.1 15 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.4701120131504e-13 2.43252255199188e-12 0.743696671752274 0.917647058823529 15.1 15 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.4701120131504e-13 2.43252255199188e-12 0.743696671752274 0.917647058823529 15.1 15 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.4701120131504e-13 2.43252255199188e-12 0.743696671752274 0.917647058823529 15.1 15 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.4701120131504e-13 2.43252255199188e-12 0.743696671752274 0.917647058823529 15.1 15 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.4701120131504e-13 2.43252255199188e-12 0.743696671752274 0.917647058823529 15.1 15 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 6.87910973868849e-24 3.62554561413101e-22 0.743332293177188 0.917197452229299 15.1 15 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 3.9030449537208e-08 2.11179960803981e-07 0.742902124026043 0.916666666666667 15.1 15 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000130634429100107 0.00040945549032919 0.742902124026043 0.916666666666667 15.1 15 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000130634429100107 0.00040945549032919 0.742902124026043 0.916666666666667 15.1 15 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000130634429100107 0.00040945549032919 0.742902124026043 0.916666666666667 15.1 15 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00864069009601226 0.0177279684316397 0.742902124026043 0.916666666666667 15.1 15 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.3114962828468e-11 1.4694954413315e-10 0.742902124026043 0.916666666666667 15.1 15 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 7.0963438310158e-10 5.17851142130025e-09 0.742902124026043 0.916666666666667 15.1 15 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 7.0963438310158e-10 5.17851142130025e-09 0.742902124026043 0.916666666666667 15.1 15 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.20434562475491e-06 9.4481440482718e-06 0.742902124026043 0.916666666666667 15.1 15 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.18343700193423e-11 2.3900237336557e-10 0.741950904917175 0.915492957746479 15.1 15 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 6.50023421556284e-08 3.42586418101701e-07 0.741465176010519 0.914893617021277 15.1 15 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 6.50023421556284e-08 3.42586418101701e-07 0.741465176010519 0.914893617021277 15.1 15 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 6.78343789328855e-13 1.03793893786555e-11 0.741254890935077 0.914634146341463 15.1 15 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 3.67315994168271e-06 1.54642207012263e-05 0.740972508119482 0.914285714285714 15.1 15 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.96436610582226e-09 1.33109188980242e-08 0.740573277242263 0.913793103448276 15.1 15 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 4.01028056605611e-19 1.46323826807637e-17 0.740243204469758 0.913385826771654 15.1 15 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000217941355722966 0.000655667123031249 0.73996575199432 0.91304347826087 15.1 15 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 6.10594331286342e-06 2.42702718832532e-05 0.738929385394888 0.911764705882353 15.1 15 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 6.10594331286342e-06 2.42702718832532e-05 0.738929385394888 0.911764705882353 15.1 15 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 9.67789956228305e-14 1.7214563846411e-12 0.738399686910734 0.911111111111111 15.1 15 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 5.40431406373575e-09 3.52767840031925e-08 0.73807808425964 0.910714285714286 15.1 15 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.65598362354645e-10 1.62514806641835e-09 0.737862082479055 0.91044776119403 15.1 15 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.65598362354645e-10 1.62514806641835e-09 0.737862082479055 0.91044776119403 15.1 15 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.65598362354645e-10 1.62514806641835e-09 0.737862082479055 0.91044776119403 15.1 15 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 5.13031435173655e-12 6.63676120229192e-11 0.737707004277609 0.91025641025641 15.1 15 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 5.02769299026627e-15 1.17285362707359e-13 0.737499199487672 0.91 15.1 15 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.61922498054317e-16 6.65563776305879e-15 0.736762437050621 0.909090909090909 15.1 15 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.61922498054317e-16 6.65563776305879e-15 0.736762437050621 0.909090909090909 15.1 15 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 8.94209810678488e-09 5.50848727530514e-08 0.736762437050621 0.909090909090909 15.1 15 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 8.94209810678488e-09 5.50848727530514e-08 0.736762437050621 0.909090909090909 15.1 15 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 8.94209810678488e-09 5.50848727530514e-08 0.736762437050621 0.909090909090909 15.1 15 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 8.94209810678488e-09 5.50848727530514e-08 0.736762437050621 0.909090909090909 15.1 15 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 8.94209810678488e-09 5.50848727530514e-08 0.736762437050621 0.909090909090909 15.1 15 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 8.94209810678488e-09 5.50848727530514e-08 0.736762437050621 0.909090909090909 15.1 15 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.96879921072162e-07 1.432068229443e-06 0.736762437050621 0.909090909090909 15.1 15 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.96879921072162e-07 1.432068229443e-06 0.736762437050621 0.909090909090909 15.1 15 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000362316763975132 0.0010250034893372 0.736762437050621 0.909090909090909 15.1 15 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000362316763975132 0.0010250034893372 0.736762437050621 0.909090909090909 15.1 15 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000362316763975132 0.0010250034893372 0.736762437050621 0.909090909090909 15.1 15 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0144644095356547 0.0283120423235717 0.736762437050621 0.909090909090909 15.1 15 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.37244808141154e-14 3.00460556899787e-13 0.736010638645468 0.908163265306122 15.1 15 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.37230506119192e-13 6.7628153283436e-12 0.735915583674701 0.908045977011494 15.1 15 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.37230506119192e-13 6.7628153283436e-12 0.735915583674701 0.908045977011494 15.1 15 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 7.20702693592765e-22 3.30825784833066e-20 0.735793012791344 0.907894736842105 15.1 15 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.47705731822561e-08 8.44117495516082e-08 0.735398062167194 0.907407407407407 15.1 15 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.74290296884783e-20 1.5217574070487e-18 0.735183660399799 0.907142857142857 15.1 15 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.74290296884783e-20 1.5217574070487e-18 0.735183660399799 0.907142857142857 15.1 15 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.179225838109e-18 4.19509591907275e-17 0.735049036034225 0.906976744186046 15.1 15 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.17009711694272e-20 2.43890227705819e-18 0.734642257375656 0.906474820143885 15.1 15 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.08038824194932e-51 5.92078493658776e-49 0.734595488706355 0.906417112299465 15.1 15 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.1882111387115e-12 1.76127546915256e-11 0.734162099037502 0.905882352941176 15.1 15 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 2.4354934089757e-08 1.33296427729709e-07 0.73398220143911 0.905660377358491 15.1 15 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 4.07287589476016e-29 3.62231399890232e-27 0.733254044493238 0.904761904761905 15.1 15 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.95532935568267e-12 2.72787615013377e-11 0.733254044493238 0.904761904761905 15.1 15 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.95532935568267e-12 2.72787615013377e-11 0.733254044493238 0.904761904761905 15.1 15 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 8.08855811914915e-07 3.71290909791911e-06 0.733254044493238 0.904761904761905 15.1 15 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000600024445065559 0.00163883835955526 0.733254044493238 0.904761904761905 15.1 15 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000600024445065559 0.00163883835955526 0.733254044493238 0.904761904761905 15.1 15 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.65948644019242e-13 2.71430943033772e-12 0.732009131005134 0.903225806451613 15.1 15 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.0188342754429e-09 1.36151714405462e-08 0.732009131005134 0.903225806451613 15.1 15 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2.76041213566756e-05 9.84853689339635e-05 0.732009131005134 0.903225806451613 15.1 15 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 2.76041213566756e-05 9.84853689339635e-05 0.732009131005134 0.903225806451613 15.1 15 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 2.76041213566756e-05 9.84853689339635e-05 0.732009131005134 0.903225806451613 15.1 15 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.02800293934602e-10 1.05240876452474e-09 0.73164603123777 0.902777777777778 15.1 15 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.33059819763112e-06 5.8620471678919e-06 0.731371492389276 0.902439024390244 15.1 15 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.33059819763112e-06 5.8620471678919e-06 0.731371492389276 0.902439024390244 15.1 15 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.33059819763112e-06 5.8620471678919e-06 0.731371492389276 0.902439024390244 15.1 15 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.33059819763112e-06 5.8620471678919e-06 0.731371492389276 0.902439024390244 15.1 15 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.68612747565839e-10 1.64339684785061e-09 0.730536275610757 0.901408450704225 15.1 15 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 8.64945579466055e-12 9.84032799733261e-11 0.730395354261295 0.901234567901235 15.1 15 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 8.64945579466055e-12 9.84032799733261e-11 0.730395354261295 0.901234567901235 15.1 15 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 2.18363504310117e-06 9.3876515599183e-06 0.729394812680115 0.9 15.1 15 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.000989526548057434 0.00257893091187862 0.729394812680115 0.9 15.1 15 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.000989526548057434 0.00257893091187862 0.729394812680115 0.9 15.1 15 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0240508941490444 0.0442748025538036 0.729394812680115 0.9 15.1 15 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.78596118807228e-14 7.38003119263954e-13 0.729394812680115 0.9 15.1 15 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 3.78596118807228e-14 7.38003119263954e-13 0.729394812680115 0.9 15.1 15 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.35733640073274e-18 1.62201908473249e-16 0.729394812680115 0.9 15.1 15 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 4.53767770108698e-05 0.000155219119438624 0.729394812680115 0.9 15.1 15 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.31575592034138e-11 2.47768471777878e-10 0.728368940932323 0.89873417721519 15.1 15 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.31575592034138e-11 2.47768471777878e-10 0.728368940932323 0.89873417721519 15.1 15 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.51594347620642e-10 3.80247785008387e-09 0.728220263867426 0.898550724637681 15.1 15 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 8.87926759579608e-09 5.50848727530514e-08 0.728021187797479 0.898305084745763 15.1 15 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 8.87926759579608e-09 5.50848727530514e-08 0.728021187797479 0.898305084745763 15.1 15 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 8.87926759579608e-09 5.50848727530514e-08 0.728021187797479 0.898305084745763 15.1 15 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.33736023530835e-17 6.3962761823919e-16 0.72748039059959 0.897637795275591 15.1 15 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 8.58003579728125e-15 1.9692566031502e-13 0.727122554696688 0.897196261682243 15.1 15 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 7.37348921582617e-10 5.35330365006155e-09 0.727011169501422 0.897058823529412 15.1 15 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.44967461689418e-08 8.31809266064686e-08 0.726600196539578 0.896551724137931 15.1 15 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 7.43500429187866e-05 0.000243189103051278 0.726600196539578 0.896551724137931 15.1 15 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 7.43500429187866e-05 0.000243189103051278 0.726600196539578 0.896551724137931 15.1 15 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.43421895039394e-24 1.87957444861945e-22 0.726294774010558 0.896174863387978 15.1 15 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 5.18378696684823e-12 6.64552148993246e-11 0.725625330444042 0.895348837209302 15.1 15 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 5.83589019102886e-06 2.33271678141406e-05 0.725129345939296 0.894736842105263 15.1 15 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 5.83589019102886e-06 2.33271678141406e-05 0.725129345939296 0.894736842105263 15.1 15 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00162438106276568 0.00403402138274966 0.725129345939296 0.894736842105263 15.1 15 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00162438106276568 0.00403402138274966 0.725129345939296 0.894736842105263 15.1 15 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 8.62231980599218e-18 2.45391221678538e-16 0.725129345939296 0.894736842105263 15.1 15 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.70487663332567e-14 7.38003119263954e-13 0.724719204906525 0.894230769230769 15.1 15 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.94870592113207e-37 2.52091684160994e-35 0.724692608730338 0.89419795221843 15.1 15 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.36599860629224e-21 2.31388364144056e-19 0.724329570925392 0.89375 15.1 15 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000121400627422404 0.000383044551711931 0.723605964960432 0.892857142857143 15.1 15 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000121400627422404 0.000383044551711931 0.723605964960432 0.892857142857143 15.1 15 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.59566165495058e-33 4.26385544582889e-31 0.723495067494538 0.89272030651341 15.1 15 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 6.36686088274981e-23 3.12415277108724e-21 0.723442438188689 0.892655367231638 15.1 15 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.1514600067175e-18 9.96561686568666e-17 0.722981269163344 0.892086330935252 15.1 15 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.22290866382156e-11 2.4146557470367e-10 0.722559787661694 0.891566265060241 15.1 15 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 7.63381250291198e-07 3.51550653451254e-06 0.722347519803979 0.891304347826087 15.1 15 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 5.15461916363297e-09 3.38019496306439e-08 0.721796950048031 0.890625 15.1 15 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.1741044843435e-14 4.48369663945044e-13 0.721216073700012 0.889908256880734 15.1 15 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.82238539420006e-52 1.00406360398667e-49 0.721024084522075 0.889671361502347 15.1 15 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 5.82642245142707e-11 6.05182419589833e-10 0.720389938449497 0.888888888888889 15.1 15 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.01029821349764e-07 5.15288300289296e-07 0.720389938449497 0.888888888888889 15.1 15 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00019749084503711 0.000601776172350766 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.95112376615743e-10 5.12510317059172e-09 0.720389938449497 0.888888888888889 15.1 15 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 1.5423674477105e-05 5.82172116204786e-05 0.720389938449497 0.888888888888889 15.1 15 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00265306282601664 0.00621961845374247 0.720389938449497 0.888888888888889 15.1 15 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0396731277454484 0.0675297377772406 0.720389938449497 0.888888888888889 15.1 15 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.8552159247897e-32 4.21997866228904e-30 0.720043597132934 0.888461538461538 15.1 15 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.51813752013105e-10 1.527698387672e-09 0.718110223454403 0.886075949367089 15.1 15 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.51813752013105e-10 1.527698387672e-09 0.718110223454403 0.886075949367089 15.1 15 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.81127398974978e-09 1.23322626192054e-08 0.717817117240748 0.885714285714286 15.1 15 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.49600144395138e-05 9.06073993556839e-05 0.717817117240748 0.885714285714286 15.1 15 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 2.49600144395138e-05 9.06073993556839e-05 0.717817117240748 0.885714285714286 15.1 15 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.49600144395138e-05 9.06073993556839e-05 0.717817117240748 0.885714285714286 15.1 15 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.63367776428067e-07 1.28207249401028e-06 0.716926525283874 0.884615384615385 15.1 15 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 2.63367776428067e-07 1.28207249401028e-06 0.716926525283874 0.884615384615385 15.1 15 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.63367776428067e-07 1.28207249401028e-06 0.716926525283874 0.884615384615385 15.1 15 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000319994130291874 0.000921764468431854 0.716926525283874 0.884615384615385 15.1 15 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000319994130291874 0.000921764468431854 0.716926525283874 0.884615384615385 15.1 15 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000319994130291874 0.000921764468431854 0.716926525283874 0.884615384615385 15.1 15 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 4.23767249679358e-07 1.99675760362161e-06 0.715092953607956 0.882352941176471 15.1 15 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.00430894579181806 0.00973274581231286 0.715092953607956 0.882352941176471 15.1 15 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00430894579181806 0.00973274581231286 0.715092953607956 0.882352941176471 15.1 15 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00430894579181806 0.00973274581231286 0.715092953607956 0.882352941176471 15.1 15 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00430894579181806 0.00973274581231286 0.715092953607956 0.882352941176471 15.1 15 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.34236065470565e-13 2.35824594030387e-12 0.713780856445373 0.880733944954128 15.1 15 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 6.80213704224738e-07 3.1426756529604e-06 0.713186039065002 0.88 15.1 15 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000516268351365603 0.00141824298068196 0.713186039065002 0.88 15.1 15 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000516268351365603 0.00141824298068196 0.713186039065002 0.88 15.1 15 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000516268351365603 0.00141824298068196 0.713186039065002 0.88 15.1 15 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000516268351365603 0.00141824298068196 0.713186039065002 0.88 15.1 15 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.01128536002634e-09 7.23145259958531e-09 0.713186039065002 0.88 15.1 15 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 9.012273158756e-08 4.62977065159198e-07 0.712627115836894 0.879310344827586 15.1 15 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 9.012273158756e-08 4.62977065159198e-07 0.712627115836894 0.879310344827586 15.1 15 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 1.44135142710805e-07 7.24750205220761e-07 0.710911123469898 0.87719298245614 15.1 15 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.02408790490591e-14 2.31313823600176e-13 0.710794580662772 0.877049180327869 15.1 15 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.92363715849823e-08 1.05688636159961e-07 0.710692381585753 0.876923076923077 15.1 15 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 8.74706947764597e-13 1.32415743262662e-11 0.710098653614504 0.876190476190476 15.1 15 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.63254898158672e-14 3.46733910566851e-13 0.709971075703326 0.87603305785124 15.1 15 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.63254898158672e-14 3.46733910566851e-13 0.709971075703326 0.87603305785124 15.1 15 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.06769474468408e-08 1.67254008493695e-07 0.709133845661223 0.875 15.1 15 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000103643930154322 0.000331427668785619 0.709133845661223 0.875 15.1 15 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000103643930154322 0.000331427668785619 0.709133845661223 0.875 15.1 15 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00082908984208298 0.00218480526904459 0.709133845661223 0.875 15.1 15 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00082908984208298 0.00218480526904459 0.709133845661223 0.875 15.1 15 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00082908984208298 0.00218480526904459 0.709133845661223 0.875 15.1 15 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00082908984208298 0.00218480526904459 0.709133845661223 0.875 15.1 15 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00695478050480494 0.0147932027777839 0.709133845661223 0.875 15.1 15 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00695478050480494 0.0147932027777839 0.709133845661223 0.875 15.1 15 1 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.064816380578698 0.102939407994963 0.709133845661223 0.875 15.1 15 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 5.14594192215457e-58 2.44089178507532e-55 0.708748656174172 0.874524714828897 15.1 15 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 4.88194117912827e-08 2.62151030109416e-07 0.707525832405756 0.873015873015873 15.1 15 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.02778173844296e-24 6.09388922418473e-23 0.707291939568597 0.872727272727273 15.1 15 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.51828669092736e-19 5.83924854375575e-18 0.706777919263678 0.872093023255814 15.1 15 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 2.12131532893245e-05 7.92291788207578e-05 0.706536285787006 0.871794871794872 15.1 15 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 2.12131532893245e-05 7.92291788207578e-05 0.706536285787006 0.871794871794872 15.1 15 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.46859576116501e-27 1.09990093059885e-25 0.706285918570214 0.8714859437751 15.1 15 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.58143530159743e-14 7.28054633453307e-13 0.705015762933806 0.869918699186992 15.1 15 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.39912606880204e-06 1.79883804480038e-05 0.704729287613638 0.869565217391304 15.1 15 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 4.39912606880204e-06 1.79883804480038e-05 0.704729287613638 0.869565217391304 15.1 15 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.52087176231362e-09 2.34121519522069e-08 0.703802012235199 0.868421052631579 15.1 15 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.72931333773785e-17 4.82512329333522e-16 0.702722147237523 0.867088607594937 15.1 15 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.01423399114009e-22 4.81084989797449e-21 0.702380189988259 0.866666666666667 15.1 15 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 3.48210000259978e-11 3.67039133607369e-10 0.70182318745853 0.865979381443299 15.1 15 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 7.5035716012188e-12 8.75211671191341e-11 0.701341166038572 0.865384615384615 15.1 15 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 2.55071234635222e-10 2.41977577923947e-09 0.701166049642558 0.865168539325843 15.1 15 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.06210653345848e-07 1.47208702605115e-06 0.700548690144744 0.864406779661017 15.1 15 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.01270137859114e-10 3.73207455015372e-09 0.699924315198091 0.863636363636364 15.1 15 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00210550642530493 0.00510414930699985 0.699924315198091 0.863636363636364 15.1 15 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00210550642530493 0.00510414930699985 0.699924315198091 0.863636363636364 15.1 15 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00210550642530493 0.00510414930699985 0.699924315198091 0.863636363636364 15.1 15 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.37874465677611e-08 7.9431321724389e-08 0.699419683391891 0.863013698630137 15.1 15 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.29216284708146e-06 9.79503823242319e-06 0.699201999083335 0.862745098039216 15.1 15 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.000415466780570015 0.00117071134406165 0.69865403513421 0.862068965517241 15.1 15 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.88099840415941e-23 1.97237883182816e-21 0.697776801368122 0.860986547085202 15.1 15 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 3.60095001153302e-06 1.52051984166513e-05 0.696977265449888 0.86 15.1 15 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.60095001153302e-06 1.52051984166513e-05 0.696977265449888 0.86 15.1 15 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.54605203566891e-09 1.07844708174356e-08 0.696023808178411 0.858823529411765 15.1 15 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.54605203566891e-09 1.07844708174356e-08 0.696023808178411 0.858823529411765 15.1 15 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.54605203566891e-09 1.07844708174356e-08 0.696023808178411 0.858823529411765 15.1 15 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.54605203566891e-09 1.07844708174356e-08 0.696023808178411 0.858823529411765 15.1 15 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.54605203566891e-09 1.07844708174356e-08 0.696023808178411 0.858823529411765 15.1 15 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 5.64026946550306e-06 2.27368369671696e-05 0.694661726362015 0.857142857142857 15.1 15 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 2.71295512018126e-05 9.77350667346312e-05 0.694661726362015 0.857142857142857 15.1 15 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 2.71295512018126e-05 9.77350667346312e-05 0.694661726362015 0.857142857142857 15.1 15 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.000654032150725352 0.00177951768734642 0.694661726362015 0.857142857142857 15.1 15 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00332653916600869 0.00763494392456511 0.694661726362015 0.857142857142857 15.1 15 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00332653916600869 0.00763494392456511 0.694661726362015 0.857142857142857 15.1 15 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0177262697140268 0.0338129782882843 0.694661726362015 0.857142857142857 15.1 15 1 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%REACT_215211.1 TERMINAL PATHWAY OF COMPLEMENT 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.10465002048399 0.15180120198646 0.694661726362015 0.857142857142857 15.1 15 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 5.30029397948793e-08 2.83545801985388e-07 0.694661726362015 0.857142857142857 15.1 15 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.89642002464847e-07 1.85438317561029e-06 0.692794356129859 0.854838709677419 15.1 15 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 1.84621939387503e-06 8.00966523623224e-06 0.692556690827584 0.854545454545454 15.1 15 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 8.80725331332748e-06 3.41491048088965e-05 0.692249706478813 0.854166666666667 15.1 15 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 9.08702050364832e-13 1.36114001859911e-11 0.691837898206071 0.853658536585366 15.1 15 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 4.23915675749476e-05 0.000145357110022049 0.691837898206071 0.853658536585366 15.1 15 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 4.23915675749476e-05 0.000145357110022049 0.691837898206071 0.853658536585366 15.1 15 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.000206555485711898 0.000623428933349249 0.691256521821024 0.852941176470588 15.1 15 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000206555485711898 0.000623428933349249 0.691256521821024 0.852941176470588 15.1 15 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000206555485711898 0.000623428933349249 0.691256521821024 0.852941176470588 15.1 15 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 9.09879486677222e-09 5.58085564457624e-08 0.690373691014101 0.851851851851852 15.1 15 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00102438802050675 0.00264076839344404 0.690373691014101 0.851851851851852 15.1 15 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00102438802050675 0.00264076839344404 0.690373691014101 0.851851851851852 15.1 15 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00102438802050675 0.00264076839344404 0.690373691014101 0.851851851851852 15.1 15 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00102438802050675 0.00264076839344404 0.690373691014101 0.851851851851852 15.1 15 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00102438802050675 0.00264076839344404 0.690373691014101 0.851851851851852 15.1 15 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00102438802050675 0.00264076839344404 0.690373691014101 0.851851851851852 15.1 15 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 6.59932773005092e-05 0.000224125139853519 0.688872878642331 0.85 15.1 15 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 6.59932773005092e-05 0.000224125139853519 0.688872878642331 0.85 15.1 15 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.00522188997944569 0.0113273619523647 0.688872878642331 0.85 15.1 15 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00522188997944569 0.0113273619523647 0.688872878642331 0.85 15.1 15 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00522188997944569 0.0113273619523647 0.688872878642331 0.85 15.1 15 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 6.59294571568335e-08 3.46190470605808e-07 0.688317783655512 0.849315068493151 15.1 15 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 4.45844442686463e-06 1.80751180040694e-05 0.688108313849165 0.849056603773585 15.1 15 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 4.45844442686463e-06 1.80751180040694e-05 0.688108313849165 0.849056603773585 15.1 15 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 4.45844442686463e-06 1.80751180040694e-05 0.688108313849165 0.849056603773585 15.1 15 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.3523559977998e-10 3.13842275320337e-09 0.687644941247247 0.848484848484849 15.1 15 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.79749073295392e-13 6.00425479221492e-12 0.687644941247247 0.848484848484849 15.1 15 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000321642065816472 0.000922775523501692 0.687644941247247 0.848484848484849 15.1 15 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.000321642065816472 0.000922775523501692 0.687644941247247 0.848484848484849 15.1 15 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 6.57002811470138e-14 1.24655333429601e-12 0.685755806793271 0.846153846153846 15.1 15 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.02793768543671 0.0502447025828498 0.685755806793271 0.846153846153846 15.1 15 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.02793768543671 0.0502447025828498 0.685755806793271 0.846153846153846 15.1 15 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.02793768543671 0.0502447025828498 0.685755806793271 0.846153846153846 15.1 15 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.02793768543671 0.0502447025828498 0.685755806793271 0.846153846153846 15.1 15 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.02793768543671 0.0502447025828498 0.685755806793271 0.846153846153846 15.1 15 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.02793768543671 0.0502447025828498 0.685755806793271 0.846153846153846 15.1 15 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.02793768543671 0.0502447025828498 0.685755806793271 0.846153846153846 15.1 15 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.02793768543671 0.0502447025828498 0.685755806793271 0.846153846153846 15.1 15 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.80922395338674e-18 2.01865118451444e-16 0.683807636887608 0.84375 15.1 15 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.71326884151769e-08 9.48630957774192e-08 0.683502501842143 0.843373493975904 15.1 15 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000158037055972499 0.000482589550748641 0.682474678531102 0.842105263157895 15.1 15 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00247140266834918 0.0059205488166008 0.680768491834774 0.84 15.1 15 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00247140266834918 0.0059205488166008 0.680768491834774 0.84 15.1 15 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00247140266834918 0.0059205488166008 0.680768491834774 0.84 15.1 15 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00247140266834918 0.0059205488166008 0.680768491834774 0.84 15.1 15 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00247140266834918 0.0059205488166008 0.680768491834774 0.84 15.1 15 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00247140266834918 0.0059205488166008 0.680768491834774 0.84 15.1 15 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 5.7428888620055e-17 1.54191148125167e-15 0.680421780099692 0.839572192513369 15.1 15 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00076881342826677 0.00208385049223545 0.679722764504767 0.838709677419355 15.1 15 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.000243005523553799 0.000717394367505 0.679016191984492 0.837837837837838 15.1 15 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 7.76777169936923e-05 0.00025178904620051 0.678506802493131 0.837209302325581 15.1 15 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 6.72845854239536e-09 4.37196187480758e-08 0.678301939328127 0.83695652173913 15.1 15 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 2.50380455334276e-05 9.06593862444465e-05 0.678122161448633 0.836734693877551 15.1 15 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 8.67051158879711e-07 3.95453140732637e-06 0.677381583915198 0.835820895522388 15.1 15 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 8.70385775880959e-14 1.56779615073241e-12 0.675365567296403 0.833333333333333 15.1 15 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 3.82133030110553e-05 0.000134931836686679 0.675365567296403 0.833333333333333 15.1 15 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00380346770352248 0.00870150247928053 0.675365567296403 0.833333333333333 15.1 15 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00380346770352248 0.00870150247928053 0.675365567296403 0.833333333333333 15.1 15 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0435830067338669 0.0734817755714367 0.675365567296403 0.833333333333333 15.1 15 1 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.0435830067338669 0.0734817755714367 0.675365567296403 0.833333333333333 15.1 15 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0435830067338669 0.0734817755714367 0.675365567296403 0.833333333333333 15.1 15 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0435830067338669 0.0734817755714367 0.675365567296403 0.833333333333333 15.1 15 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0435830067338669 0.0734817755714367 0.675365567296403 0.833333333333333 15.1 15 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_223937.1 FGFR2B LIGAND BINDING AND ACTIVATION 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605630 MULTIFUNCTIONAL ANION EXCHANGERS 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.166467785833196 0.228366824747213 0.675365567296403 0.833333333333333 15.1 15 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.00117941932681886 0.00300235009313639 0.675365567296403 0.833333333333333 15.1 15 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0125883606208251 0.0252654967044205 0.675365567296403 0.833333333333333 15.1 15 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0125883606208251 0.0252654967044205 0.675365567296403 0.833333333333333 15.1 15 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0125883606208251 0.0252654967044205 0.675365567296403 0.833333333333333 15.1 15 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0125883606208251 0.0252654967044205 0.675365567296403 0.833333333333333 15.1 15 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0125883606208251 0.0252654967044205 0.675365567296403 0.833333333333333 15.1 15 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.27763261736467e-07 1.57039434831984e-06 0.671811011679054 0.828947368421053 15.1 15 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0005665986502035 0.00155350651105892 0.671506335483281 0.828571428571429 15.1 15 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 2.84979263024395e-05 0.000101128551442323 0.670170447547969 0.826923076923077 15.1 15 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 8.80047968882413e-05 0.000283327660570062 0.669492823232956 0.826086956521739 15.1 15 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.50323401149713e-06 6.54159632526122e-06 0.669492823232956 0.826086956521739 15.1 15 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000273657318997467 0.000797980256011055 0.668611911623439 0.825 15.1 15 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.45931830205069e-10 5.38812687503458e-09 0.668256456061704 0.824561403508772 15.1 15 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 8.16939310942147e-41 1.16250463947068e-38 0.667777190135769 0.823970037453184 15.1 15 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.000858712772971141 0.00225868442872077 0.667420090034092 0.823529411764706 15.1 15 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0193020091654104 0.0365249455350784 0.667420090034092 0.823529411764706 15.1 15 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0193020091654104 0.0365249455350784 0.667420090034092 0.823529411764706 15.1 15 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0193020091654104 0.0365249455350784 0.667420090034092 0.823529411764706 15.1 15 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0193020091654104 0.0365249455350784 0.667420090034092 0.823529411764706 15.1 15 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0193020091654104 0.0365249455350784 0.667420090034092 0.823529411764706 15.1 15 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.67654849003654e-09 1.16377000064488e-08 0.665717487763597 0.821428571428571 15.1 15 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.25620172509868e-14 2.7930860231491e-13 0.665088265185371 0.820652173913043 15.1 15 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000412677382258315 0.00116515856141584 0.664975327799535 0.82051282051282 15.1 15 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00882118649917565 0.0180352706728835 0.663086193345559 0.818181818181818 15.1 15 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0671900749092982 0.105183142569781 0.663086193345559 0.818181818181818 15.1 15 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0012944315124617 0.00328337975442602 0.663086193345559 0.818181818181818 15.1 15 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0012944315124617 0.00328337975442602 0.663086193345559 0.818181818181818 15.1 15 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 1.23488574980512e-06 5.54335148887284e-06 0.661147344827005 0.815789473684211 15.1 15 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00410988617303446 0.00935738883876485 0.660357443578705 0.814814814814815 15.1 15 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 6.87764156021891e-10 5.12510317059172e-09 0.660115377067129 0.814516129032258 15.1 15 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 6.87764156021891e-10 5.12510317059172e-09 0.660115377067129 0.814516129032258 15.1 15 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 6.87764156021891e-10 5.12510317059172e-09 0.660115377067129 0.814516129032258 15.1 15 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 9.74044618136869e-16 2.3492635450996e-14 0.659928640043914 0.814285714285714 15.1 15 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.74227020994045e-18 5.63466024714833e-17 0.659285434741727 0.813492063492063 15.1 15 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.74227020994045e-18 5.63466024714833e-17 0.659285434741727 0.813492063492063 15.1 15 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.74227020994045e-18 5.63466024714833e-17 0.659285434741727 0.813492063492063 15.1 15 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000144297412633582 0.000441581114360402 0.658481428113993 0.8125 15.1 15 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000144297412633582 0.000441581114360402 0.658481428113993 0.8125 15.1 15 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 1.12772118521146e-05 4.325464276431e-05 0.658481428113993 0.8125 15.1 15 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0293136498999349 0.0514979306266757 0.658481428113993 0.8125 15.1 15 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0293136498999349 0.0514979306266757 0.658481428113993 0.8125 15.1 15 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0293136498999349 0.0514979306266757 0.658481428113993 0.8125 15.1 15 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0293136498999349 0.0514979306266757 0.658481428113993 0.8125 15.1 15 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0293136498999349 0.0514979306266757 0.658481428113993 0.8125 15.1 15 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.73257806403084e-61 3.36722929255795e-58 0.658252231654503 0.812217194570136 15.1 15 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0132771309365529 0.0265534272508984 0.656069408230792 0.80952380952381 15.1 15 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.33277002520692e-08 7.70947864174571e-08 0.655718568975053 0.809090909090909 15.1 15 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.006149032292877 0.0131580044402466 0.654585088302667 0.807692307692308 15.1 15 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.006149032292877 0.0131580044402466 0.654585088302667 0.807692307692308 15.1 15 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.006149032292877 0.0131580044402466 0.654585088302667 0.807692307692308 15.1 15 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.006149032292877 0.0131580044402466 0.654585088302667 0.807692307692308 15.1 15 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.48202387810559e-11 2.6357611780181e-10 0.653579581254584 0.806451612903226 15.1 15 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00289027723745256 0.00675347209999178 0.653579581254583 0.806451612903226 15.1 15 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00137297464786978 0.00346408319843741 0.652853381719856 0.805555555555556 15.1 15 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000657394378281709 0.00178525229063907 0.652304304022867 0.804878048780488 15.1 15 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000316709826208967 0.000917877968829655 0.651874591042615 0.804347826086957 15.1 15 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000968757635301711 0.0025340847702837 0.648350944604547 0.8 15.1 15 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0198092678989929 0.0372372367506828 0.648350944604547 0.8 15.1 15 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0198092678989929 0.0372372367506828 0.648350944604547 0.8 15.1 15 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0198092678989929 0.0372372367506828 0.648350944604547 0.8 15.1 15 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.102162062131065 0.150649341360109 0.648350944604547 0.8 15.1 15 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.000225322140727576 0.00067644178534882 0.648350944604547 0.8 15.1 15 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000465995278718149 0.00129009976968079 0.648350944604547 0.8 15.1 15 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0020271692640417 0.00494796202869869 0.648350944604547 0.8 15.1 15 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.00913172784421562 0.0185900553967365 0.648350944604547 0.8 15.1 15 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00913172784421562 0.0185900553967365 0.648350944604547 0.8 15.1 15 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0440430745045667 0.0740819090070903 0.648350944604547 0.8 15.1 15 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0440430745045667 0.0740819090070903 0.648350944604547 0.8 15.1 15 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 5.3943485344272e-07 2.52505196200326e-06 0.646626606985918 0.797872340425532 15.1 15 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.24523946394844e-48 1.48116262619977e-45 0.646483096172588 0.797695262483995 15.1 15 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.86336456477458e-05 6.99622104399533e-05 0.646001846979168 0.797101449275362 15.1 15 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 8.36393151998774e-09 5.40994297861025e-08 0.644522100443496 0.795275590551181 15.1 15 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00297506093621102 0.00690621812761546 0.64358365824716 0.794117647058823 15.1 15 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00297506093621102 0.00690621812761546 0.64358365824716 0.794117647058823 15.1 15 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.65991615755035e-10 2.50666271006235e-09 0.64312230795451 0.793548387096774 15.1 15 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 9.89787749235663e-08 5.06643153655521e-07 0.642509945103605 0.792792792792793 15.1 15 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 9.54585876012215e-11 9.84330218525639e-10 0.642420905477066 0.792682926829268 15.1 15 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0134529157920688 0.0268492274503701 0.641597288931583 0.791666666666667 15.1 15 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00206950429591572 0.00504264488542478 0.639820011122908 0.789473684210526 15.1 15 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000337577271113922 0.000966544178662196 0.638999729057366 0.788461538461538 15.1 15 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.29292452584365e-28 1.81268422237529e-26 0.638527445443872 0.787878787878788 15.1 15 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.00433837186091661 0.00978368170853302 0.638527445443872 0.787878787878788 15.1 15 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.00917671039532306 0.0186549412750639 0.63677324916518 0.785714285714286 15.1 15 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0653795430865482 0.10360254990218 0.63677324916518 0.785714285714286 15.1 15 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0653795430865482 0.10360254990218 0.63677324916518 0.785714285714286 15.1 15 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0196478880971173 0.0370808285970795 0.634256358852274 0.782608695652174 15.1 15 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0196478880971173 0.0370808285970795 0.634256358852274 0.782608695652174 15.1 15 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 7.62627390314665e-08 3.98977491330062e-07 0.633972193816946 0.782258064516129 15.1 15 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000341105469405783 0.000974684905551062 0.633615695863535 0.781818181818182 15.1 15 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.00628371083978094 0.0134260067943067 0.633155219340378 0.78125 15.1 15 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 8.13560114232669e-18 2.36264498480222e-16 0.631446088686944 0.779141104294479 15.1 15 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 6.08318374570336e-80 8.65637047013589e-77 0.630457463079793 0.777921239509361 15.1 15 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 8.75535948984525e-07 3.98047174250792e-06 0.63034119614331 0.777777777777778 15.1 15 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0132860437123259 0.0265534272508984 0.63034119614331 0.777777777777778 15.1 15 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.79442843385133e-05 0.000197733133366198 0.630341196143309 0.777777777777778 15.1 15 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0427997790714587 0.0725912820246553 0.630341196143309 0.777777777777778 15.1 15 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0427997790714587 0.0725912820246553 0.630341196143309 0.777777777777778 15.1 15 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0427997790714587 0.0725912820246553 0.630341196143309 0.777777777777778 15.1 15 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.152817765495071 0.217242437861624 0.630341196143309 0.777777777777778 15.1 15 1 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.152817765495071 0.217242437861624 0.630341196143309 0.777777777777778 15.1 15 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.152817765495071 0.217242437861624 0.630341196143309 0.777777777777778 15.1 15 1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.152817765495071 0.217242437861624 0.630341196143309 0.777777777777778 15.1 15 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 2.194297178379e-07 1.08797382746806e-06 0.62959699166144 0.776859504132231 15.1 15 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.00297399300903412 0.00690621812761546 0.628089977585655 0.775 15.1 15 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00903613836194305 0.0184482423085294 0.6274363980044 0.774193548387097 15.1 15 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0284273420236357 0.0502510654653833 0.626248071493028 0.772727272727273 15.1 15 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.26030973557666e-10 2.17325726603081e-09 0.624713149749173 0.770833333333333 15.1 15 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00423473330099643 0.00962623879763245 0.623414369812064 0.769230769230769 15.1 15 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0190740463486778 0.0363351645972805 0.623414369812064 0.769230769230769 15.1 15 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0957340777243899 0.142648788064719 0.623414369812064 0.769230769230769 15.1 15 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0957340777243899 0.142648788064719 0.623414369812064 0.769230769230769 15.1 15 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0957340777243899 0.142648788064719 0.623414369812064 0.769230769230769 15.1 15 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0957340777243899 0.142648788064719 0.623414369812064 0.769230769230769 15.1 15 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 9.89312816470969e-06 3.80484361577889e-05 0.622758144159631 0.768421052631579 15.1 15 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 9.89312816470969e-06 3.80484361577889e-05 0.622758144159631 0.768421052631579 15.1 15 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.81548457755178e-05 0.000100160863846405 0.621964568952036 0.767441860465116 15.1 15 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00291371894120022 0.00679708533332444 0.621964568952036 0.767441860465116 15.1 15 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.28684500625979e-30 3.34084317421977e-28 0.621378335322787 0.766718506998445 15.1 15 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0128952346952403 0.0258449562976436 0.621336321912691 0.766666666666667 15.1 15 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.26061466700316e-26 8.54216510069287e-25 0.620248167233334 0.765323992994746 15.1 15 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.52598880194339e-45 3.10211723595064e-43 0.619794947044387 0.764764764764765 15.1 15 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0618514822871399 0.0999031320029512 0.619747226460229 0.764705882352941 15.1 15 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0618514822871399 0.0999031320029512 0.619747226460229 0.764705882352941 15.1 15 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.20930145479048e-07 1.98997872763018e-06 0.618655481492888 0.763358778625954 15.1 15 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.20930145479048e-07 1.98997872763018e-06 0.618655481492888 0.763358778625954 15.1 15 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.18120636303039e-06 5.31916662845646e-06 0.617793420576054 0.762295081967213 15.1 15 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00410894583691929 0.00935738883876485 0.617477090099569 0.761904761904762 15.1 15 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.10306560760789e-13 5.01779813593867e-12 0.617337767651441 0.76173285198556 15.1 15 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0013485706821257 0.00340855431734436 0.615333072425612 0.759259259259259 15.1 15 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.012362895148732 0.0249892042565988 0.613968697542185 0.757575757575758 15.1 15 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.012362895148732 0.0249892042565988 0.613968697542185 0.757575757575758 15.1 15 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.012362895148732 0.0249892042565988 0.613968697542185 0.757575757575758 15.1 15 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000313797716811078 0.000911294185759517 0.613617858286446 0.757142857142857 15.1 15 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 8.71315058091292e-12 9.84032799733261e-11 0.61339084465038 0.756862745098039 15.1 15 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.12536543718224e-21 1.38981094284698e-19 0.612770709839663 0.75609756097561 15.1 15 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00272158126645474 0.00636975352329785 0.611963901795108 0.755102040816326 15.1 15 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000900941167840106 0.00236102998496588 0.61115048056986 0.754098360655738 15.1 15 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.000900941167840106 0.00236102998496588 0.61115048056986 0.754098360655738 15.1 15 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.000434992832261889 0.00122330988203294 0.610765382598486 0.753623188405797 15.1 15 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 9.90401596740467e-05 0.000318135772496994 0.607829010566763 0.75 15.1 15 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0172934209284295 0.0331205087229545 0.607829010566763 0.75 15.1 15 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0882313483184621 0.136917348590154 0.607829010566763 0.75 15.1 15 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.138011279435592 0.197178765699646 0.607829010566763 0.75 15.1 15 1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.138011279435592 0.197178765699646 0.607829010566763 0.75 15.1 15 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.138011279435592 0.197178765699646 0.607829010566763 0.75 15.1 15 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.224150940199866 0.296713291073869 0.607829010566763 0.75 15.1 15 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.224150940199866 0.296713291073869 0.607829010566763 0.75 15.1 15 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.224150940199866 0.296713291073869 0.607829010566763 0.75 15.1 15 1 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.224150940199866 0.296713291073869 0.607829010566763 0.75 15.1 15 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.26580598095747e-18 1.31961780671793e-16 0.606920447023315 0.748878923766816 15.1 15 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.64559781908351e-05 0.000225159183251329 0.605696277196353 0.747368421052632 15.1 15 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000135840897673886 0.000417498050518227 0.605500163782982 0.747126436781609 15.1 15 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00247741916968651 0.00592498735876286 0.60414519838151 0.745454545454545 15.1 15 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.36583834742486e-07 2.05035906547379e-06 0.603957488206465 0.745222929936306 15.1 15 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0162656171381107 0.0312361311572626 0.602040162847079 0.742857142857143 15.1 15 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00112925386202305 0.00288496992039282 0.601689323591341 0.742424242424242 15.1 15 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0356111967382544 0.061798454827483 0.600324948707914 0.740740740740741 15.1 15 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0356111967382544 0.061798454827483 0.600324948707914 0.740740740740741 15.1 15 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.20213686678959e-06 1.74843297118175e-05 0.597770374458093 0.737588652482269 15.1 15 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0806773026297982 0.125605909893001 0.597165343714714 0.736842105263158 15.1 15 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0806773026297982 0.125605909893001 0.597165343714714 0.736842105263158 15.1 15 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00972981331761136 0.0197511046376048 0.594321699220835 0.733333333333333 15.1 15 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0329877014067297 0.0574559352530922 0.594321699220835 0.733333333333333 15.1 15 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0329877014067297 0.0574559352530922 0.594321699220835 0.733333333333333 15.1 15 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0329877014067297 0.0574559352530922 0.594321699220835 0.733333333333333 15.1 15 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.124054831686998 0.178493453478865 0.594321699220835 0.733333333333333 15.1 15 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.124054831686998 0.178493453478865 0.594321699220835 0.733333333333333 15.1 15 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0490209625250692 0.0821635214053869 0.592243651321461 0.730769230769231 15.1 15 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0490209625250692 0.0821635214053869 0.592243651321461 0.730769230769231 15.1 15 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00583599195440489 0.012582752350179 0.589409949640497 0.727272727272727 15.1 15 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0734714772592415 0.114763899165643 0.589409949640497 0.727272727272727 15.1 15 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.195420694722443 0.261111407126794 0.589409949640497 0.727272727272727 15.1 15 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0304414896742895 0.0533475859686133 0.589409949640497 0.727272727272727 15.1 15 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00542829215616551 0.0117214867044363 0.586869389512736 0.724137931034483 15.1 15 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00542829215616551 0.0117214867044363 0.586869389512736 0.724137931034483 15.1 15 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00542829215616551 0.0117214867044363 0.586869389512736 0.724137931034483 15.1 15 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.11138591064791 0.161243286726324 0.585316824990216 0.722222222222222 15.1 15 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0667657040031008 0.105183142569781 0.583515850144092 0.72 15.1 15 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00399895459323953 0.00913404877396446 0.578884771968345 0.714285714285714 15.1 15 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.0375454505609181 0.0650757322145999 0.578884771968345 0.714285714285714 15.1 15 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.060604079425555 0.0981110409813024 0.578884771968345 0.714285714285714 15.1 15 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.100031710822297 0.148896573744905 0.578884771968345 0.714285714285714 15.1 15 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.171620414318993 0.231923883737823 0.578884771968345 0.714285714285714 15.1 15 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.171620414318993 0.231923883737823 0.578884771968345 0.714285714285714 15.1 15 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.171620414318993 0.231923883737823 0.578884771968345 0.714285714285714 15.1 15 1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.32101219920621 0.394133183322207 0.578884771968345 0.714285714285714 15.1 15 1 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.32101219920621 0.394133183322207 0.578884771968345 0.714285714285714 15.1 15 1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_225157.1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE 0.32101219920621 0.394133183322207 0.578884771968345 0.714285714285714 15.1 15 1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_216831.1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE 0.32101219920621 0.394133183322207 0.578884771968345 0.714285714285714 15.1 15 1 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.32101219920621 0.394133183322207 0.578884771968345 0.714285714285714 15.1 15 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0549817485813643 0.089110510513988 0.575150031504033 0.709677419354839 15.1 15 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0312478446511222 0.054626146116151 0.573237115656459 0.707317073170732 15.1 15 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.049871697985479 0.0834910896862784 0.572074362886365 0.705882352941177 15.1 15 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0452376467474008 0.0760013829062 0.569497451341832 0.702702702702703 15.1 15 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0011570591648953 0.0029507082287563 0.568064495856788 0.700934579439252 15.1 15 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00176098853933778 0.00436392962263761 0.567307076528979 0.7 15.1 15 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.134383024586461 0.192963717443525 0.567307076528979 0.7 15.1 15 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.134383024586461 0.192963717443525 0.567307076528979 0.7 15.1 15 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.271014406677752 0.349007692943386 0.567307076528979 0.7 15.1 15 1 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.271014406677752 0.349007692943386 0.567307076528979 0.7 15.1 15 1 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.271014406677752 0.349007692943386 0.567307076528979 0.7 15.1 15 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.271014406677752 0.349007692943386 0.567307076528979 0.7 15.1 15 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0728159984060922 0.113865017287768 0.567307076528978 0.7 15.1 15 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 3.65304948698889e-05 0.000129310682089184 0.565116701716125 0.697297297297297 15.1 15 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.033803189832693 0.058804326567142 0.56378343009091 0.695652173913043 15.1 15 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.119572084749841 0.172451808762666 0.56378343009091 0.695652173913043 15.1 15 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.119572084749841 0.172451808762666 0.56378343009091 0.695652173913043 15.1 15 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 5.21396993591068e-06 2.10780659625025e-05 0.563480971169188 0.695278969957081 15.1 15 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.030691860555746 0.0537201938140548 0.562345207054964 0.693877551020408 15.1 15 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.00243268940966887 0.00588727386047416 0.561072932830858 0.692307692307692 15.1 15 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0534539294064201 0.0867331146469052 0.561072932830858 0.692307692307692 15.1 15 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.233134983285798 0.30803257308792 0.561072932830858 0.692307692307692 15.1 15 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00736127251174232 0.0156344638570288 0.56030328546072 0.691358024691358 15.1 15 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 4.31618637503422e-06 1.78961131507422e-05 0.559361599266668 0.690196078431373 15.1 15 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0954216103567029 0.142648788064719 0.558923228107368 0.689655172413793 15.1 15 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0395272070358884 0.0675297377772406 0.557176593019532 0.6875 15.1 15 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0395272070358884 0.0675297377772406 0.557176593019532 0.6875 15.1 15 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0855128708575051 0.132988869104076 0.557176593019532 0.6875 15.1 15 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.202866495097775 0.269541570984252 0.557176593019532 0.6875 15.1 15 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.202866495097775 0.269541570984252 0.557176593019532 0.6875 15.1 15 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.202866495097775 0.269541570984252 0.557176593019532 0.6875 15.1 15 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.202866495097775 0.269541570984252 0.557176593019532 0.6875 15.1 15 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.202866495097775 0.269541570984252 0.557176593019532 0.6875 15.1 15 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.00593238068459279 0.0127712219579055 0.55451067630652 0.684210526315789 15.1 15 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.156946497028845 0.222889087097851 0.552571827787966 0.681818181818182 15.1 15 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.013640523034166 0.0271855241983449 0.550297869648921 0.679012345679012 15.1 15 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000283544020334526 0.000825118897619694 0.547148957058406 0.6751269035533 15.1 15 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0640907266744881 0.102939407994963 0.546165197900569 0.673913043478261 15.1 15 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00129762253021286 0.00328561718948914 0.543586920019056 0.670731707317073 15.1 15 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0175984247127173 0.0336141723036197 0.543470644742047 0.670588235294118 15.1 15 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0175984247127173 0.0336141723036197 0.543470644742047 0.670588235294118 15.1 15 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0163585873578384 0.0313723312805985 0.540292453837122 0.666666666666667 15.1 15 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0806428862530841 0.125605909893001 0.540292453837122 0.666666666666667 15.1 15 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.178915857003223 0.241553381893346 0.540292453837122 0.666666666666667 15.1 15 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.310239525296145 0.382557057622543 0.540292453837122 0.666666666666667 15.1 15 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.310239525296145 0.382557057622543 0.540292453837122 0.666666666666667 15.1 15 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.310239525296145 0.382557057622543 0.540292453837122 0.666666666666667 15.1 15 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.310239525296145 0.382557057622543 0.540292453837122 0.666666666666667 15.1 15 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.310239525296145 0.382557057622543 0.540292453837122 0.666666666666667 15.1 15 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.140632834257924 0.200722691222694 0.540292453837122 0.666666666666667 15.1 15 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.231857259085087 0.306629070332787 0.540292453837122 0.666666666666667 15.1 15 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.266751579582985 0.344766119660842 0.540292453837122 0.666666666666667 15.1 15 1 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.366817289609455 0.445756620934461 0.540292453837122 0.666666666666667 15.1 15 1 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.366817289609455 0.445756620934461 0.540292453837122 0.666666666666667 15.1 15 1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.366817289609455 0.445756620934461 0.540292453837122 0.666666666666667 15.1 15 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.366817289609455 0.445756620934461 0.540292453837122 0.666666666666667 15.1 15 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0271726759080775 0.0498925391189603 0.534152766861701 0.659090909090909 15.1 15 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0301017933245284 0.0528173266347767 0.531287579606504 0.655555555555556 15.1 15 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.20020362915246 0.267251186007459 0.529902214340255 0.653846153846154 15.1 15 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00629708409556791 0.0134344087975909 0.528546965710229 0.652173913043478 15.1 15 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00824938255226433 0.0174945922084533 0.525284330119425 0.648148148148148 15.1 15 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.29695952032203 0.377839063287532 0.524401499312501 0.647058823529412 15.1 15 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.29695952032203 0.377839063287532 0.524401499312501 0.647058823529412 15.1 15 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.343861207426045 0.41929262910648 0.520996294771511 0.642857142857143 15.1 15 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.343861207426045 0.41929262910648 0.520996294771511 0.642857142857143 15.1 15 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.343861207426045 0.41929262910648 0.520996294771511 0.642857142857143 15.1 15 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.343861207426045 0.41929262910648 0.520996294771511 0.642857142857143 15.1 15 1 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.343861207426045 0.41929262910648 0.520996294771511 0.642857142857143 15.1 15 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.343861207426045 0.41929262910648 0.520996294771511 0.642857142857143 15.1 15 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.343861207426045 0.41929262910648 0.520996294771511 0.642857142857143 15.1 15 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0138532227827338 0.0275323128768578 0.519904059352703 0.641509433962264 15.1 15 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0138532227827338 0.0275323128768578 0.519904059352703 0.641509433962264 15.1 15 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.403303402599543 0.477852407909367 0.515733705935435 0.636363636363636 15.1 15 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.185324755311038 0.249968840575931 0.513936724381653 0.634146341463415 15.1 15 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.240598187971205 0.317598535698539 0.513277831145266 0.633333333333333 15.1 15 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0265039449689138 0.048727537068171 0.512406391703594 0.632258064516129 15.1 15 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0238848511025604 0.0442748025538036 0.51211769397445 0.631901840490798 15.1 15 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.324319026624402 0.397849978350452 0.511856008898326 0.631578947368421 15.1 15 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.482447630883451 0.565039488680783 0.506524175472302 0.625 15.1 15 1 SPERM MOTILITY AND TAXES%REACTOME%REACT_196630.2 SPERM MOTILITY AND TAXES 0.482447630883451 0.565039488680783 0.506524175472302 0.625 15.1 15 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.482447630883451 0.565039488680783 0.506524175472302 0.625 15.1 15 1 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.482447630883451 0.565039488680783 0.506524175472302 0.625 15.1 15 1 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.482447630883451 0.565039488680783 0.506524175472302 0.625 15.1 15 1 RELAXIN RECEPTORS%REACTOME%REACT_198713.2 RELAXIN RECEPTORS 0.482447630883451 0.565039488680783 0.506524175472302 0.625 15.1 15 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.135021862906286 0.193490544728746 0.502677156418082 0.620253164556962 15.1 15 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0857559059184395 0.133221238124388 0.496536374829186 0.612676056338028 15.1 15 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.399263073694369 0.47743811249335 0.495268082684029 0.611111111111111 15.1 15 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.110642065381274 0.160329591687936 0.492052056173094 0.607142857142857 15.1 15 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.119613447117886 0.172451808762666 0.490995697100159 0.605839416058394 15.1 15 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.119613447117886 0.172451808762666 0.490995697100159 0.605839416058394 15.1 15 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.134962061916871 0.193490544728746 0.488646851632103 0.602941176470588 15.1 15 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.510521614007008 0.594981373244858 0.48626320845341 0.6 15.1 15 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.510521614007008 0.594981373244858 0.48626320845341 0.6 15.1 15 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.510521614007008 0.594981373244858 0.48626320845341 0.6 15.1 15 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.510521614007008 0.594981373244858 0.48626320845341 0.6 15.1 15 1 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.510521614007008 0.594981373244858 0.48626320845341 0.6 15.1 15 1 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.510521614007008 0.594981373244858 0.48626320845341 0.6 15.1 15 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.393353991161668 0.472524362865885 0.48626320845341 0.6 15.1 15 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.553267572628245 0.625337375575848 0.463107817574676 0.571428571428571 15.1 15 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.553267572628245 0.625337375575848 0.463107817574676 0.571428571428571 15.1 15 1 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.553267572628245 0.625337375575848 0.463107817574676 0.571428571428571 15.1 15 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.553267572628245 0.625337375575848 0.463107817574676 0.571428571428571 15.1 15 1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.553267572628245 0.625337375575848 0.463107817574676 0.571428571428571 15.1 15 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.553267572628245 0.625337375575848 0.463107817574676 0.571428571428571 15.1 15 1 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.553267572628245 0.625337375575848 0.463107817574676 0.571428571428571 15.1 15 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.477129226424324 0.56158386203624 0.458738875899444 0.566037735849057 15.1 15 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.435721374978833 0.515833208481597 0.458429960831498 0.565656565656566 15.1 15 1 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.626985557475948 0.686836372816223 0.450243711530935 0.555555555555556 15.1 15 1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.626985557475948 0.686836372816223 0.450243711530935 0.555555555555556 15.1 15 1 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198585.2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS 0.626985557475948 0.686836372816223 0.450243711530935 0.555555555555556 15.1 15 1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.626985557475948 0.686836372816223 0.450243711530935 0.555555555555556 15.1 15 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.533938809031358 0.621763441286107 0.446994530107516 0.551546391752577 15.1 15 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.566374213208843 0.639643258250939 0.446568252661295 0.551020408163265 15.1 15 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.569783013512005 0.642844468111698 0.446334278328374 0.550731707317073 15.1 15 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.60348302956957 0.664158044143464 0.442846850555784 0.546428571428571 15.1 15 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.602569445675353 0.663665883278659 0.442057462230373 0.545454545454545 15.1 15 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.622208235686714 0.683708354735285 0.438434040408812 0.540983606557377 15.1 15 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.645076843206552 0.706111036833018 0.434163578976259 0.535714285714286 15.1 15 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.660304620832767 0.722224039542681 0.433755913643887 0.535211267605634 15.1 15 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.678619974860292 0.74168680816144 0.426546674081939 0.526315789473684 15.1 15 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.709132431189094 0.774440099449025 0.42022746409554 0.518518518518518 15.1 15 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.846216665818097 0.891314815291748 0.419033636072541 0.517045454545455 15.1 15 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.72226291131801 0.788174940801785 0.418290932002933 0.516129032258065 15.1 15 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.899867692684238 0.945027104568023 0.414556191538622 0.511520737327189 15.1 15 1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.743449500944889 0.809017977709724 0.405219340377842 0.5 15.1 15 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.744774104567631 0.809017977709724 0.405219340377842 0.5 15.1 15 1 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.744774104567631 0.809017977709724 0.405219340377842 0.5 15.1 15 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.761397963357323 0.816152387739765 0.405219340377842 0.5 15.1 15 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.757541644546813 0.816152387739765 0.405219340377842 0.5 15.1 15 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.761397963357323 0.816152387739765 0.405219340377842 0.5 15.1 15 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.784741484768837 0.84024614960576 0.405219340377842 0.5 15.1 15 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.832365137054338 0.879981864805589 0.393641644938475 0.485714285714286 15.1 15 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.823184285039083 0.871570861317422 0.378204717685986 0.466666666666667 15.1 15 1 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.825800586607459 0.873690880849378 0.374048621887239 0.461538461538462 15.1 15 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.996408278688591 1 0.370361762710931 0.456989247311828 15.1 15 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.90442011454901 0.948408123067974 0.366004565502567 0.451612903225806 15.1 15 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.90442011454901 0.948408123067974 0.366004565502567 0.451612903225806 15.1 15 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.988976165380174 1 0.348796394249282 0.430379746835443 15.1 15 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.88473689275249 0.929823189355091 0.347330863181007 0.428571428571429 15.1 15 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.912845462953465 0.948413492888604 0.347330863181007 0.428571428571429 15.1 15 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.970748085078877 1 0.344867523725823 0.425531914893617 15.1 15 1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.925771964561429 0.960184770824281 0.324175472302273 0.4 15.1 15 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.960912177105471 0.993012366028384 0.317128179426137 0.391304347826087 15.1 15 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.995539226060959 1 0.303914505283381 0.375 15.1 15 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.991665966288149 1 0.287575015752017 0.354838709677419 15.1 15 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999996437888484 1 0.27765028877741 0.342592592592593 15.1 15 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.274229041431184 0.338371116708648 15.1 15 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999322376991133 1 0.270146226918561 0.333333333333333 15.1 15 1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.975640321325769 1 0.270146226918561 0.333333333333333 15.1 15 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.995368513343742 1 0.270146226918561 0.333333333333333 15.1 15 1 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_220332.1 ANDROGEN BIOSYNTHESIS 0.975640321325769 1 0.270146226918561 0.333333333333333 15.1 15 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.994563645353141 1 0.259340377841819 0.32 15.1 15 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999629307870661 1 0.258650642794367 0.319148936170213 15.1 15 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.999057707248553 1 0.255928004449163 0.315789473684211 15.1 15 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.995546189026587 1 0.246655250664773 0.304347826086957 15.1 15 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999627417138 1 0.243131604226705 0.3 15.1 15 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.241812626265258 0.298372513562387 15.1 15 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.998856403992027 1 0.231553908787338 0.285714285714286 15.1 15 1 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.999780553602125 1 0.209145466001467 0.258064516129032 15.1 15 1 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.998574952470158 1 0.202609670188921 0.25 15.1 15 1 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.999999994181682 1 0.115776954393669 0.142857142857143 15.1 15 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0274503424126925 0.0338709677419355 15.1 15 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 2.40935625512241e-07 1.50065715425762e-06 1.44991694951975 1 15.2 15 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000128129999958965 0.000468712056405161 1.44991694951975 1 15.2 15 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.000128129999958965 0.000468712056405161 1.44991694951975 1 15.2 15 2 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%REACT_209347.1 NGF-INDEPENDANT TRKA ACTIVATION 0.0113255041066748 0.0250251433909911 1.44991694951975 1 15.2 15 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 5.90676392876079e-07 3.45898151054593e-06 1.44991694951975 1 15.2 15 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 5.90676392876079e-07 3.45898151054593e-06 1.44991694951975 1 15.2 15 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 3.54969491946049e-06 1.83015067767836e-05 1.44991694951975 1 15.2 15 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.000314028685403116 0.00107161347560823 1.44991694951975 1 15.2 15 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00076960740618051 0.0023450778136935 1.44991694951975 1 15.2 15 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00076960740618051 0.0023450778136935 1.44991694951975 1 15.2 15 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00076960740618051 0.0023450778136935 1.44991694951975 1 15.2 15 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00076960740618051 0.0023450778136935 1.44991694951975 1 15.2 15 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00076960740618051 0.0023450778136935 1.44991694951975 1 15.2 15 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00188603861238615 0.00526241754004999 1.44991694951975 1 15.2 15 2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00188603861238615 0.00526241754004999 1.44991694951975 1 15.2 15 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.00188603861238615 0.00526241754004999 1.44991694951975 1 15.2 15 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 2.13283910383824e-05 9.22501533362253e-05 1.44991694951975 1 15.2 15 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 2.13283910383824e-05 9.22501533362253e-05 1.44991694951975 1 15.2 15 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00462182339823088 0.0115383415713729 1.44991694951975 1 15.2 15 2 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_217410.1 ACTIVATION OF TRKA RECEPTORS 0.00462182339823088 0.0115383415713729 1.44991694951975 1 15.2 15 2 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.00462182339823088 0.0115383415713729 1.44991694951975 1 15.2 15 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00462182339823088 0.0115383415713729 1.44991694951975 1 15.2 15 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00462182339823088 0.0115383415713729 1.44991694951975 1 15.2 15 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00462182339823088 0.0115383415713729 1.44991694951975 1 15.2 15 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 2.91392281413156e-09 3.54402749103351e-08 1.39415091299976 0.961538461538462 15.2 15 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 2.91392281413156e-09 3.54402749103351e-08 1.39415091299976 0.961538461538462 15.2 15 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 1.14571157874501e-06 6.52139030621659e-06 1.37360553112398 0.947368421052632 15.2 15 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 1.14571157874501e-06 6.52139030621659e-06 1.37360553112398 0.947368421052632 15.2 15 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 2.66620171829418e-06 1.43170001703118e-05 1.36936600787977 0.944444444444444 15.2 15 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 6.18652867069752e-06 2.9943640470757e-05 1.36462771719506 0.941176470588235 15.2 15 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 6.18652867069752e-06 2.9943640470757e-05 1.36462771719506 0.941176470588235 15.2 15 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 1.43084438188716e-05 6.42300175213069e-05 1.35929714017477 0.9375 15.2 15 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 1.43084438188716e-05 6.42300175213069e-05 1.35929714017477 0.9375 15.2 15 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 1.43084438188716e-05 6.42300175213069e-05 1.35929714017477 0.9375 15.2 15 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 1.43084438188716e-05 6.42300175213069e-05 1.35929714017477 0.9375 15.2 15 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 3.29729077938962e-05 0.000134058422259184 1.35325581955177 0.933333333333333 15.2 15 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 3.29729077938962e-05 0.000134058422259184 1.35325581955177 0.933333333333333 15.2 15 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 3.29729077938962e-05 0.000134058422259184 1.35325581955177 0.933333333333333 15.2 15 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 3.29729077938962e-05 0.000134058422259184 1.35325581955177 0.933333333333333 15.2 15 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 1.04876373848171e-08 1.09734617636726e-07 1.34635145312548 0.928571428571429 15.2 15 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 7.56720853034505e-05 0.000286386641986197 1.34635145312548 0.928571428571429 15.2 15 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 7.56720853034505e-05 0.000286386641986197 1.34635145312548 0.928571428571429 15.2 15 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 7.56720853034505e-05 0.000286386641986197 1.34635145312548 0.928571428571429 15.2 15 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 5.44501878057435e-08 4.84266357797332e-07 1.33838487647977 0.923076923076923 15.2 15 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00017285355270774 0.000610348897030059 1.33838487647977 0.923076923076923 15.2 15 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 9.8295199191153e-11 1.60774791320702e-09 1.33235611577491 0.918918918918919 15.2 15 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.21974391775635e-10 3.43336477713835e-09 1.32909053705977 0.916666666666667 15.2 15 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000392716168035437 0.00127879887211539 1.32909053705977 0.916666666666667 15.2 15 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 6.29639669681199e-07 3.67203790965716e-06 1.3238372147789 0.91304347826087 15.2 15 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 2.51852363725586e-09 3.15130116390098e-08 1.31810631774523 0.909090909090909 15.2 15 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000886656275000588 0.00263956460110008 1.31810631774523 0.909090909090909 15.2 15 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.000886656275000588 0.00263956460110008 1.31810631774523 0.909090909090909 15.2 15 2 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.000886656275000588 0.00263956460110008 1.31810631774523 0.909090909090909 15.2 15 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 3.16135846498669e-06 1.66000483235279e-05 1.31182962099406 0.904761904761905 15.2 15 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.78520743911256e-08 2.63772959176559e-07 1.30492525456778 0.9 15.2 15 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 7.03775101200466e-06 3.30518801652892e-05 1.30492525456778 0.9 15.2 15 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 7.03775101200466e-06 3.30518801652892e-05 1.30492525456778 0.9 15.2 15 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00198711685440047 0.00546937579073861 1.30492525456778 0.9 15.2 15 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00198711685440047 0.00546937579073861 1.30492525456778 0.9 15.2 15 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.00198711685440047 0.00546937579073861 1.30492525456778 0.9 15.2 15 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00198711685440047 0.00546937579073861 1.30492525456778 0.9 15.2 15 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00198711685440047 0.00546937579073861 1.30492525456778 0.9 15.2 15 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.00198711685440047 0.00546937579073861 1.30492525456778 0.9 15.2 15 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 1.35944954482528e-07 1.01282549857926e-06 1.29456870492835 0.892857142857143 15.2 15 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 1.35944954482528e-07 1.01282549857926e-06 1.29456870492835 0.892857142857143 15.2 15 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 2.98615747946544e-07 1.84752264925188e-06 1.28881506623978 0.888888888888889 15.2 15 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.72488672952438e-09 3.37175114444626e-08 1.28881506623978 0.888888888888889 15.2 15 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00441423717239966 0.011196897497905 1.28881506623978 0.888888888888889 15.2 15 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00441423717239966 0.011196897497905 1.28881506623978 0.888888888888889 15.2 15 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.00441423717239966 0.011196897497905 1.28881506623978 0.888888888888889 15.2 15 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00441423717239966 0.011196897497905 1.28881506623978 0.888888888888889 15.2 15 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00441423717239966 0.011196897497905 1.28881506623978 0.888888888888889 15.2 15 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 1.42220995072498e-06 7.96773527512458e-06 1.27592691557738 0.88 15.2 15 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 2.81753266302438e-08 2.63772959176559e-07 1.27416944048705 0.878787878787879 15.2 15 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 2.81753266302438e-08 2.63772959176559e-07 1.27416944048705 0.878787878787879 15.2 15 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00016362415561907 0.00058209293361484 1.26867733082978 0.875 15.2 15 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00016362415561907 0.00058209293361484 1.26867733082978 0.875 15.2 15 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00016362415561907 0.00058209293361484 1.26867733082978 0.875 15.2 15 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00016362415561907 0.00058209293361484 1.26867733082978 0.875 15.2 15 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00016362415561907 0.00058209293361484 1.26867733082978 0.875 15.2 15 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00970105705582567 0.0221582731788763 1.26867733082978 0.875 15.2 15 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.00970105705582567 0.0221582731788763 1.26867733082978 0.875 15.2 15 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00970105705582567 0.0221582731788763 1.26867733082978 0.875 15.2 15 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00970105705582567 0.0221582731788763 1.26867733082978 0.875 15.2 15 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00970105705582567 0.0221582731788763 1.26867733082978 0.875 15.2 15 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00970105705582567 0.0221582731788763 1.26867733082978 0.875 15.2 15 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00970105705582567 0.0221582731788763 1.26867733082978 0.875 15.2 15 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.31204166030311e-07 9.87849355879009e-07 1.2628308915172 0.870967741935484 15.2 15 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 6.64109201195964e-06 3.15009131100619e-05 1.26079734740848 0.869565217391304 15.2 15 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 6.64109201195964e-06 3.15009131100619e-05 1.26079734740848 0.869565217391304 15.2 15 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000353216739115553 0.00119673195181293 1.25659468958378 0.866666666666667 15.2 15 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000353216739115553 0.00119673195181293 1.25659468958378 0.866666666666667 15.2 15 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 9.92642909140036e-15 3.71718647291124e-13 1.24278595673122 0.857142857142857 15.2 15 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 2.42436541858176e-09 3.08024284878736e-08 1.24278595673122 0.857142857142857 15.2 15 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 3.02961062941125e-05 0.000125689094042338 1.24278595673122 0.857142857142857 15.2 15 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000755942357133474 0.00232836790952583 1.24278595673122 0.857142857142857 15.2 15 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000755942357133474 0.00232836790952583 1.24278595673122 0.857142857142857 15.2 15 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000755942357133474 0.00232836790952583 1.24278595673122 0.857142857142857 15.2 15 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0210365321132992 0.0430100362029092 1.24278595673122 0.857142857142857 15.2 15 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.16312361169616e-07 8.80385584810442e-07 1.23669386870802 0.852941176470588 15.2 15 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.78466120188481e-10 6.74116127750701e-09 1.2339718719317 0.851063829787234 15.2 15 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 9.24384998771816e-14 2.48188651557036e-12 1.23351143466606 0.850746268656716 15.2 15 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.00226243388428e-09 1.37136484943975e-08 1.22927741372327 0.847826086956522 15.2 15 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00160196055233777 0.00458669993154254 1.22685280343979 0.846153846153846 15.2 15 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00160196055233777 0.00458669993154254 1.22685280343979 0.846153846153846 15.2 15 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00160196055233777 0.00458669993154254 1.22685280343979 0.846153846153846 15.2 15 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00160196055233777 0.00458669993154254 1.22685280343979 0.846153846153846 15.2 15 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.0917561936252e-09 2.7307973059896e-08 1.22437431292779 0.844444444444444 15.2 15 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 5.10705435317041e-07 3.02805764356729e-06 1.22336742615729 0.84375 15.2 15 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000134395951679054 0.000487871018467586 1.22098269433242 0.842105263157895 15.2 15 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 4.3487623007585e-09 5.20024265040282e-08 1.21924834391434 0.840909090909091 15.2 15 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.57968456358561e-14 4.78274709357941e-13 1.21793023759659 0.84 15.2 15 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.57968456358561e-14 4.78274709357941e-13 1.21793023759659 0.84 15.2 15 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.57968456358561e-14 4.78274709357941e-13 1.21793023759659 0.84 15.2 15 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.57968456358561e-14 4.78274709357941e-13 1.21793023759659 0.84 15.2 15 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.57968456358561e-14 4.78274709357941e-13 1.21793023759659 0.84 15.2 15 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.17927422431018e-05 5.39584315496264e-05 1.21793023759659 0.84 15.2 15 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 9.00462385982212e-09 9.56237294964692e-08 1.21388395773747 0.837209302325581 15.2 15 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.19533205591538e-06 1.19691858834007e-05 1.20826412459979 0.833333333333333 15.2 15 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 2.00677947410886e-07 1.38623650080432e-06 1.20826412459979 0.833333333333333 15.2 15 2 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.00027959112313144 0.000958694381243468 1.20826412459979 0.833333333333333 15.2 15 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00027959112313144 0.000958694381243468 1.20826412459979 0.833333333333333 15.2 15 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.73275087266453e-09 2.34828999219202e-08 1.20826412459979 0.833333333333333 15.2 15 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 2.44390764842314e-05 0.000104122173164854 1.20826412459979 0.833333333333333 15.2 15 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 2.44390764842314e-05 0.000104122173164854 1.20826412459979 0.833333333333333 15.2 15 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 2.44390764842314e-05 0.000104122173164854 1.20826412459979 0.833333333333333 15.2 15 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00335635680982634 0.00865234735576608 1.20826412459979 0.833333333333333 15.2 15 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00335635680982634 0.00865234735576608 1.20826412459979 0.833333333333333 15.2 15 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00335635680982634 0.00865234735576608 1.20826412459979 0.833333333333333 15.2 15 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00335635680982634 0.00865234735576608 1.20826412459979 0.833333333333333 15.2 15 2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 KLOTHO-MEDIATED LIGAND BINDING%REACTOME%REACT_222862.1 KLOTHO-MEDIATED LIGAND BINDING 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 SCAVENGING BY CLASS B RECEPTORS%REACTOME%REACT_196592.2 SCAVENGING BY CLASS B RECEPTORS 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0448439076488947 0.0801669354075089 1.20826412459979 0.833333333333333 15.2 15 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 4.12117136163839e-07 2.49550078621763e-06 1.20135975817351 0.828571428571429 15.2 15 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 4.51141688736016e-06 2.26047402489912e-05 1.19993126856807 0.827586206896552 15.2 15 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 5.02749849534177e-05 0.000196542042826136 1.19775748003806 0.826086956521739 15.2 15 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.24587992996176e-11 2.33274623728367e-10 1.19675684722265 0.825396825396825 15.2 15 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000576163780500566 0.00181389614967324 1.19404925254568 0.823529411764706 15.2 15 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000576163780500566 0.00181389614967324 1.19404925254568 0.823529411764706 15.2 15 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000576163780500566 0.00181389614967324 1.19404925254568 0.823529411764706 15.2 15 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.47874155462498e-08 1.51384836851176e-07 1.1921539362718 0.822222222222222 15.2 15 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.666936467188e-10 4.03728786468993e-09 1.19100320853408 0.821428571428571 15.2 15 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.16626398174462e-17 1.80223745840904e-15 1.1889318986062 0.82 15.2 15 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.99560008756084e-08 2.75015414490263e-07 1.18629568597071 0.818181818181818 15.2 15 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.99560008756084e-08 2.75015414490263e-07 1.18629568597071 0.818181818181818 15.2 15 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.99560008756084e-08 2.75015414490263e-07 1.18629568597071 0.818181818181818 15.2 15 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00693918946169994 0.0166665832900489 1.18629568597071 0.818181818181818 15.2 15 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00693918946169994 0.0166665832900489 1.18629568597071 0.818181818181818 15.2 15 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00693918946169994 0.0166665832900489 1.18629568597071 0.818181818181818 15.2 15 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00693918946169994 0.0166665832900489 1.18629568597071 0.818181818181818 15.2 15 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00693918946169994 0.0166665832900489 1.18629568597071 0.818181818181818 15.2 15 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 5.69579108952471e-09 6.53637961322069e-08 1.18360567307735 0.816326530612245 15.2 15 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.76697352165475e-14 8.03551698227492e-13 1.17699140608074 0.811764705882353 15.2 15 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.17144891432252e-10 5.99593111624338e-09 1.1749327004729 0.810344827586207 15.2 15 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.17144891432252e-10 5.99593111624338e-09 1.1749327004729 0.810344827586207 15.2 15 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.86122662335792e-13 7.01987152592814e-12 1.17461626290208 0.810126582278481 15.2 15 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000207531332299061 0.000720285575272106 1.17374229246837 0.80952380952381 15.2 15 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000207531332299061 0.000720285575272106 1.17374229246837 0.80952380952381 15.2 15 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000207531332299061 0.000720285575272106 1.17374229246837 0.80952380952381 15.2 15 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 3.7584190892339e-05 0.000151079953784741 1.1710867669198 0.807692307692308 15.2 15 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.68106435541023e-09 9.4298889906479e-08 1.16561950843745 0.803921568627451 15.2 15 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.68106435541023e-09 9.4298889906479e-08 1.16561950843745 0.803921568627451 15.2 15 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 8.68106435541023e-09 9.4298889906479e-08 1.16561950843745 0.803921568627451 15.2 15 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 4.34419506178381e-13 1.03029826215306e-11 1.16351360146647 0.802469135802469 15.2 15 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 4.34419506178381e-13 1.03029826215306e-11 1.16351360146647 0.802469135802469 15.2 15 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 7.50244134487499e-05 0.000286386641986197 1.1599335596158 0.8 15.2 15 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000415758970548383 0.00134155332220034 1.1599335596158 0.8 15.2 15 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000415758970548383 0.00134155332220034 1.1599335596158 0.8 15.2 15 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000415758970548383 0.00134155332220034 1.1599335596158 0.8 15.2 15 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00236684482920516 0.00636676784869365 1.1599335596158 0.8 15.2 15 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00236684482920516 0.00636676784869365 1.1599335596158 0.8 15.2 15 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00236684482920516 0.00636676784869365 1.1599335596158 0.8 15.2 15 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00236684482920516 0.00636676784869365 1.1599335596158 0.8 15.2 15 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0141227184443964 0.030084772973617 1.1599335596158 0.8 15.2 15 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 2.56028185101624e-06 1.38527797490346e-05 1.1599335596158 0.8 15.2 15 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.69166745506171e-12 3.64733755841335e-11 1.15626288379423 0.79746835443038 15.2 15 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.69166745506171e-12 3.64733755841335e-11 1.15626288379423 0.79746835443038 15.2 15 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.96154480749945e-25 2.53752569188337e-23 1.1548757097919 0.796511627906977 15.2 15 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 2.5244377753849e-18 1.56185867581422e-16 1.1528028205198 0.795081967213115 15.2 15 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000148451437136327 0.000536158363058358 1.1478509183698 0.791666666666667 15.2 15 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000148451437136327 0.000536158363058358 1.1478509183698 0.791666666666667 15.2 15 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.74944658125602e-10 2.76606942791925e-09 1.14694922872458 0.791044776119403 15.2 15 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.74944658125602e-10 2.76606942791925e-09 1.14694922872458 0.791044776119403 15.2 15 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 3.50784469374503e-07 2.14234463484943e-06 1.14644596008538 0.790697674418605 15.2 15 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 9.91575685999825e-06 4.56638252808334e-05 1.14235880871253 0.787878787878788 15.2 15 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 5.33813265637551e-05 0.000208114048493763 1.13922046033695 0.785714285714286 15.2 15 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00470402726808686 0.0116212340320965 1.13922046033695 0.785714285714286 15.2 15 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00470402726808686 0.0116212340320965 1.13922046033695 0.785714285714286 15.2 15 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00470402726808686 0.0116212340320965 1.13922046033695 0.785714285714286 15.2 15 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00470402726808686 0.0116212340320965 1.13922046033695 0.785714285714286 15.2 15 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00470402726808686 0.0116212340320965 1.13922046033695 0.785714285714286 15.2 15 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00470402726808686 0.0116212340320965 1.13922046033695 0.785714285714286 15.2 15 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 6.62065097968172e-10 9.23645720008538e-09 1.13762714500781 0.784615384615385 15.2 15 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 1.32710858445617e-06 7.46433010150645e-06 1.13164249718615 0.780487804878049 15.2 15 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 5.60894135426834e-36 1.33025392452064e-33 1.13008232830216 0.779411764705882 15.2 15 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.77882346481239e-10 2.78161075871212e-09 1.12771318295981 0.777777777777778 15.2 15 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 7.01299011608177e-06 3.30518801652892e-05 1.12771318295981 0.777777777777778 15.2 15 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00161416808129252 0.0045939223593585 1.12771318295981 0.777777777777778 15.2 15 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00161416808129252 0.0045939223593585 1.12771318295981 0.777777777777778 15.2 15 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00161416808129252 0.0045939223593585 1.12771318295981 0.777777777777778 15.2 15 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0282049266478166 0.0534428903060493 1.12771318295981 0.777777777777778 15.2 15 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 4.82657177903952e-12 9.15761552209766e-11 1.12581786668592 0.776470588235294 15.2 15 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.55116170377105e-29 5.61478122718467e-27 1.12482346308035 0.775784753363229 15.2 15 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 3.7287446601794e-05 0.000150311718170971 1.12251634801529 0.774193548387097 15.2 15 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 6.61076832677789e-08 5.7012868660636e-07 1.12163386660962 0.773584905660377 15.2 15 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 1.34790828926086e-05 6.12803033743834e-05 1.11850736105809 0.771428571428571 15.2 15 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.58686031129839e-23 1.61293015926972e-21 1.11714912503981 0.770491803278688 15.2 15 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000199825155303452 0.000700372403933034 1.11532073039981 0.769230769230769 15.2 15 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000199825155303452 0.000700372403933034 1.11532073039981 0.769230769230769 15.2 15 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00920434433478821 0.0213318924892567 1.11532073039981 0.769230769230769 15.2 15 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00920434433478821 0.0213318924892567 1.11532073039981 0.769230769230769 15.2 15 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00920434433478821 0.0213318924892567 1.11532073039981 0.769230769230769 15.2 15 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00920434433478821 0.0213318924892567 1.11532073039981 0.769230769230769 15.2 15 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00920434433478821 0.0213318924892567 1.11532073039981 0.769230769230769 15.2 15 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00920434433478821 0.0213318924892567 1.11532073039981 0.769230769230769 15.2 15 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00920434433478821 0.0213318924892567 1.11532073039981 0.769230769230769 15.2 15 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.46794730339573e-20 1.09941526985901e-18 1.11462365494331 0.76875 15.2 15 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 4.59325297571121e-10 6.53619898443705e-09 1.11226505716584 0.767123287671233 15.2 15 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 6.33735462401794e-09 7.15718700791868e-08 1.11009266447606 0.765625 15.2 15 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.35608216993449e-11 4.08866454611802e-10 1.10876002022099 0.764705882352941 15.2 15 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.35608216993449e-11 4.08866454611802e-10 1.10876002022099 0.764705882352941 15.2 15 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.35608216993449e-11 4.08866454611802e-10 1.10876002022099 0.764705882352941 15.2 15 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.57099412940069e-05 0.000108884662087416 1.10876002022099 0.764705882352941 15.2 15 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00312030226734116 0.00813221634876642 1.10876002022099 0.764705882352941 15.2 15 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00312030226734116 0.00813221634876642 1.10876002022099 0.764705882352941 15.2 15 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 9.93403361838119e-20 6.73149039950306e-18 1.10821677670299 0.764331210191083 15.2 15 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.26306742540262e-12 6.72948542948975e-11 1.10692584318175 0.763440860215054 15.2 15 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 3.16126670952543e-30 5.62310315956836e-28 1.10636233095885 0.763052208835341 15.2 15 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 3.24314680219339e-08 2.93948910797528e-07 1.1058688598032 0.76271186440678 15.2 15 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 3.24314680219339e-08 2.93948910797528e-07 1.1058688598032 0.76271186440678 15.2 15 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.48159086503127e-25 2.1083038009395e-23 1.10469862820552 0.761904761904762 15.2 15 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 3.38396207119617e-06 1.75743723624531e-05 1.10469862820552 0.761904761904762 15.2 15 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00108208741294622 0.00318801322696165 1.10469862820552 0.761904761904762 15.2 15 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.4269177534692e-16 1.19086343558161e-14 1.10416752309581 0.761538461538461 15.2 15 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.31592227868944e-19 8.51162455715943e-18 1.10339591755906 0.761006289308176 15.2 15 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.000380970345480321 0.0012666373869591 1.10193688163501 0.76 15.2 15 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000380970345480321 0.0012666373869591 1.10193688163501 0.76 15.2 15 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000380970345480321 0.0012666373869591 1.10193688163501 0.76 15.2 15 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000380970345480321 0.0012666373869591 1.10193688163501 0.76 15.2 15 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000380970345480321 0.0012666373869591 1.10193688163501 0.76 15.2 15 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000380970345480321 0.0012666373869591 1.10193688163501 0.76 15.2 15 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.2490032029414e-08 2.22245247068446e-07 1.09913059076497 0.758064516129032 15.2 15 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 4.86424754718478e-05 0.000192504966404982 1.09842193145436 0.757575757575758 15.2 15 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 6.37143159337408e-06 3.06302268830112e-05 1.09627866914908 0.75609756097561 15.2 15 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 6.37143159337408e-06 3.06302268830112e-05 1.09627866914908 0.75609756097561 15.2 15 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 8.28236664172481e-17 4.209217046848e-15 1.09526100503291 0.755395683453237 15.2 15 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.10964897158204e-07 1.90734072696606e-06 1.09427694303377 0.754716981132076 15.2 15 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 3.10964897158204e-07 1.90734072696606e-06 1.09427694303377 0.754716981132076 15.2 15 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.53596315978613e-13 3.9739555934103e-12 1.09402824372854 0.754545454545455 15.2 15 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.55135279075253e-08 1.55463029664848e-07 1.09301431579181 0.753846153846154 15.2 15 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.11946414101099e-09 2.74181588423512e-08 1.09240318114502 0.753424657534247 15.2 15 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.85652676802517e-13 7.01987152592814e-12 1.09076320973046 0.752293577981651 15.2 15 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.82200189511962e-12 7.66015309402143e-11 1.08743771213981 0.75 15.2 15 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 7.82780803167603e-08 6.47614583085756e-07 1.08743771213981 0.75 15.2 15 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 7.82780803167603e-08 6.47614583085756e-07 1.08743771213981 0.75 15.2 15 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 7.82780803167603e-08 6.47614583085756e-07 1.08743771213981 0.75 15.2 15 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 7.82780803167603e-08 6.47614583085756e-07 1.08743771213981 0.75 15.2 15 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 7.82780803167603e-08 6.47614583085756e-07 1.08743771213981 0.75 15.2 15 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 7.82780803167603e-08 6.47614583085756e-07 1.08743771213981 0.75 15.2 15 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 7.82780803167603e-08 6.47614583085756e-07 1.08743771213981 0.75 15.2 15 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00204901515266638 0.00557504505209229 1.08743771213981 0.75 15.2 15 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00204901515266638 0.00557504505209229 1.08743771213981 0.75 15.2 15 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00204901515266638 0.00557504505209229 1.08743771213981 0.75 15.2 15 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00204901515266638 0.00557504505209229 1.08743771213981 0.75 15.2 15 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 5.79489304091974e-07 3.42163186607004e-06 1.08743771213981 0.75 15.2 15 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 3.28773612221891e-05 0.000134058422259184 1.08743771213981 0.75 15.2 15 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 9.12376295640179e-05 0.00034166091281473 1.08743771213981 0.75 15.2 15 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 9.12376295640179e-05 0.00034166091281473 1.08743771213981 0.75 15.2 15 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000718441385278738 0.00222732481754171 1.08743771213981 0.75 15.2 15 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000718441385278738 0.00222732481754171 1.08743771213981 0.75 15.2 15 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000718441385278738 0.00222732481754171 1.08743771213981 0.75 15.2 15 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00594302551401969 0.0144810364836473 1.08743771213981 0.75 15.2 15 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00594302551401969 0.0144810364836473 1.08743771213981 0.75 15.2 15 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00594302551401969 0.0144810364836473 1.08743771213981 0.75 15.2 15 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00594302551401969 0.0144810364836473 1.08743771213981 0.75 15.2 15 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00594302551401969 0.0144810364836473 1.08743771213981 0.75 15.2 15 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00594302551401969 0.0144810364836473 1.08743771213981 0.75 15.2 15 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0176876874173208 0.0369055413414185 1.08743771213981 0.75 15.2 15 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0176876874173208 0.0369055413414185 1.08743771213981 0.75 15.2 15 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0550429572857199 0.0966989237254067 1.08743771213981 0.75 15.2 15 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 7.04920624089265e-15 2.78639457799729e-13 1.08458354491635 0.748031496062992 15.2 15 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.30216211918405e-11 2.40646324103754e-10 1.08004017668308 0.744897959183674 15.2 15 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.93248118466298e-06 1.55127164526967e-05 1.07972538794024 0.74468085106383 15.2 15 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 9.41553618005308e-11 1.55794278886227e-09 1.07938261797582 0.744444444444444 15.2 15 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 8.92074447465909e-15 3.43087010471348e-13 1.0790079624333 0.744186046511628 15.2 15 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.53434546684556e-10 3.87782107453895e-09 1.0790079624333 0.744186046511628 15.2 15 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 2.2097986978926e-05 9.50013156223916e-05 1.07814337271982 0.743589743589744 15.2 15 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 2.2097986978926e-05 9.50013156223916e-05 1.07814337271982 0.743589743589744 15.2 15 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.44363739389491e-17 2.43203692750479e-15 1.07789878484034 0.743421052631579 15.2 15 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 8.52241667451717e-16 4.04246630927931e-14 1.07708116250039 0.742857142857143 15.2 15 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.31606454778752e-12 6.74108550214521e-11 1.07708116250039 0.742857142857143 15.2 15 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000474290433212427 0.00151666356508154 1.07401255519982 0.740740740740741 15.2 15 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000474290433212427 0.00151666356508154 1.07401255519982 0.740740740740741 15.2 15 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.97629696210457e-06 1.09002735545535e-05 1.07293854264462 0.74 15.2 15 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.97629696210457e-06 1.09002735545535e-05 1.07293854264462 0.74 15.2 15 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 5.39831109303367e-06 2.63075228951607e-05 1.07167774529721 0.739130434782609 15.2 15 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00133884638794502 0.00390405411894623 1.07167774529721 0.739130434782609 15.2 15 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00133884638794502 0.00390405411894623 1.07167774529721 0.739130434782609 15.2 15 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.28872088681747e-09 2.93409893868582e-08 1.06931375027082 0.7375 15.2 15 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00382643426389348 0.00981083956309987 1.06835985754087 0.736842105263158 15.2 15 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00382643426389348 0.00981083956309987 1.06835985754087 0.736842105263158 15.2 15 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.53309289296643e-15 1.4787032902033e-13 1.06672461286096 0.735714285714286 15.2 15 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 3.6148862909877e-06 1.85703364334856e-05 1.06524510576961 0.73469387755102 15.2 15 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 6.40873527284962e-15 2.60560865521857e-13 1.06396783346054 0.733812949640288 15.2 15 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0111312789750115 0.0249839274155226 1.06327242964782 0.733333333333333 15.2 15 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0111312789750115 0.0249839274155226 1.06327242964782 0.733333333333333 15.2 15 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0111312789750115 0.0249839274155226 1.06327242964782 0.733333333333333 15.2 15 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.12105561364096e-08 1.1559870566747e-07 1.06327242964782 0.733333333333333 15.2 15 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.70176534703677e-05 0.000113410386101278 1.06091484111201 0.731707317073171 15.2 15 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.70176534703677e-05 0.000113410386101278 1.06091484111201 0.731707317073171 15.2 15 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 2.70176534703677e-05 0.000113410386101278 1.06091484111201 0.731707317073171 15.2 15 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.46942067390837e-11 4.2337176132188e-10 1.05955469387982 0.730769230769231 15.2 15 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00087265014738896 0.00261757032135803 1.05955469387982 0.730769230769231 15.2 15 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00087265014738896 0.00261757032135803 1.05955469387982 0.730769230769231 15.2 15 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00087265014738896 0.00261757032135803 1.05955469387982 0.730769230769231 15.2 15 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 7.42319627998826e-05 0.000284722595860466 1.0580475037036 0.72972972972973 15.2 15 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.88845299865439e-09 2.51146599727589e-08 1.05758648082617 0.729411764705882 15.2 15 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.88845299865439e-09 2.51146599727589e-08 1.05758648082617 0.729411764705882 15.2 15 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 6.56744999863766e-06 3.13945418339999e-05 1.05723110902482 0.729166666666667 15.2 15 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.00379209982555e-13 2.64517807046621e-12 1.05448505419618 0.727272727272727 15.2 15 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 1.60910464599874e-06 8.97943494610278e-06 1.05448505419618 0.727272727272727 15.2 15 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00246281790096594 0.00655063527677483 1.05448505419618 0.727272727272727 15.2 15 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00246281790096594 0.00655063527677483 1.05448505419618 0.727272727272727 15.2 15 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00246281790096594 0.00655063527677483 1.05448505419618 0.727272727272727 15.2 15 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00246281790096594 0.00655063527677483 1.05448505419618 0.727272727272727 15.2 15 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0332787957315871 0.0619839349817389 1.05448505419618 0.727272727272727 15.2 15 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.96643523890362e-07 2.41206724143583e-06 1.05235907626434 0.725806451612903 15.2 15 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.89554804925845e-05 0.000192504966404982 1.05118978840182 0.725 15.2 15 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.89554804925845e-05 0.000192504966404982 1.05118978840182 0.725 15.2 15 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 9.82373998101334e-08 7.5156892435387e-07 1.05066445617373 0.72463768115942 15.2 15 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000568129117519849 0.00180055174661636 1.04993985999706 0.724137931034483 15.2 15 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000568129117519849 0.00180055174661636 1.04993985999706 0.724137931034483 15.2 15 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.27612577592798e-12 2.92891448249276e-11 1.04912689843299 0.723577235772358 15.2 15 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 6.09055343008154e-09 6.93348602480482e-08 1.04813273459259 0.72289156626506 15.2 15 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000134275576855274 0.000487871018467586 1.04716224131982 0.722222222222222 15.2 15 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000134275576855274 0.000487871018467586 1.04716224131982 0.722222222222222 15.2 15 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00703625115106759 0.0167155014824193 1.04716224131982 0.722222222222222 15.2 15 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.00703625115106759 0.0167155014824193 1.04716224131982 0.722222222222222 15.2 15 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00703625115106759 0.0167155014824193 1.04716224131982 0.722222222222222 15.2 15 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00703625115106759 0.0167155014824193 1.04716224131982 0.722222222222222 15.2 15 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00158622405904609 0.00457849256799714 1.04394020365422 0.72 15.2 15 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00158622405904609 0.00457849256799714 1.04394020365422 0.72 15.2 15 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00158622405904609 0.00457849256799714 1.04394020365422 0.72 15.2 15 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00158622405904609 0.00457849256799714 1.04394020365422 0.72 15.2 15 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.08666076445219e-08 1.12869946555874e-07 1.04323292709348 0.719512195121951 15.2 15 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.81248523939307e-34 3.68452356522334e-32 1.04285470433373 0.719251336898396 15.2 15 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.05086499135121e-12 7.8964121680723e-11 1.04250226948941 0.71900826446281 15.2 15 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.05086499135121e-12 7.8964121680723e-11 1.04250226948941 0.71900826446281 15.2 15 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.5624337957986e-15 6.9479477856919e-14 1.04212780746732 0.71875 15.2 15 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 7.57236795310525e-39 2.69386989931719e-36 1.04148963979588 0.71830985915493 15.2 15 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.12143233415699e-05 9.22501533362253e-05 1.040157811612 0.717391304347826 15.2 15 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.26808199841529e-06 7.16063763390856e-06 1.03910714715582 0.716666666666667 15.2 15 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.26808199841529e-06 7.16063763390856e-06 1.03910714715582 0.716666666666667 15.2 15 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.8157814335721e-09 5.71071414997759e-08 1.03800872522437 0.715909090909091 15.2 15 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 7.57766918608391e-11 1.2836932442616e-09 1.03755524828019 0.715596330275229 15.2 15 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00102275338511855 0.00301945657058858 1.03565496394268 0.714285714285714 15.2 15 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00102275338511855 0.00301945657058858 1.03565496394268 0.714285714285714 15.2 15 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0204551370015417 0.0423692284617087 1.03565496394268 0.714285714285714 15.2 15 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0204551370015417 0.0423692284617087 1.03565496394268 0.714285714285714 15.2 15 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0204551370015417 0.0423692284617087 1.03565496394268 0.714285714285714 15.2 15 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0204551370015417 0.0423692284617087 1.03565496394268 0.714285714285714 15.2 15 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0204551370015417 0.0423692284617087 1.03565496394268 0.714285714285714 15.2 15 2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.104362346487883 0.166488362166209 1.03565496394268 0.714285714285714 15.2 15 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.104362346487883 0.166488362166209 1.03565496394268 0.714285714285714 15.2 15 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.104362346487883 0.166488362166209 1.03565496394268 0.714285714285714 15.2 15 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.104362346487883 0.166488362166209 1.03565496394268 0.714285714285714 15.2 15 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.104362346487883 0.166488362166209 1.03565496394268 0.714285714285714 15.2 15 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.104362346487883 0.166488362166209 1.03565496394268 0.714285714285714 15.2 15 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.104362346487883 0.166488362166209 1.03565496394268 0.714285714285714 15.2 15 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00446633450196681 0.0112887992829463 1.03565496394268 0.714285714285714 15.2 15 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00446633450196681 0.0112887992829463 1.03565496394268 0.714285714285714 15.2 15 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.94733477057403e-23 2.79603825235122e-21 1.03167167561982 0.711538461538462 15.2 15 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 9.16728163697736e-06 4.2630855455617e-05 1.03167167561982 0.711538461538462 15.2 15 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000156604455401776 0.000564172506422094 1.03020414834298 0.710526315789474 15.2 15 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000660258788018761 0.00206494122055098 1.02897331901402 0.709677419354839 15.2 15 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.4971152097062e-08 1.52171067386566e-07 1.02842946419424 0.709302325581395 15.2 15 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 8.77235528481084e-20 6.24153078514291e-18 1.02729541714852 0.708520179372197 15.2 15 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.41497180832744e-07 1.50065715425762e-06 1.02702450590982 0.708333333333333 15.2 15 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 2.46701518303087e-05 0.00010479291359561 1.02702450590982 0.708333333333333 15.2 15 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00284554425156314 0.00748467554523909 1.02702450590982 0.708333333333333 15.2 15 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00284554425156314 0.00748467554523909 1.02702450590982 0.708333333333333 15.2 15 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00284554425156314 0.00748467554523909 1.02702450590982 0.708333333333333 15.2 15 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 9.90950160732793e-09 1.04453487312797e-07 1.02634570583982 0.707865168539326 15.2 15 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000101971895796275 0.000376898721345712 1.02555101307495 0.707317073170732 15.2 15 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000101971895796275 0.000376898721345712 1.02555101307495 0.707317073170732 15.2 15 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000101971895796275 0.000376898721345712 1.02555101307495 0.707317073170732 15.2 15 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000101971895796275 0.000376898721345712 1.02555101307495 0.707317073170732 15.2 15 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 6.5564874808809e-09 7.34636353172719e-08 1.02439784476939 0.706521739130435 15.2 15 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 2.62195407367056e-08 2.50405412539141e-07 1.0234707878963 0.705882352941177 15.2 15 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 2.62195407367056e-08 2.50405412539141e-07 1.0234707878963 0.705882352941177 15.2 15 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 2.62195407367056e-08 2.50405412539141e-07 1.0234707878963 0.705882352941177 15.2 15 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 2.62195407367056e-08 2.50405412539141e-07 1.0234707878963 0.705882352941177 15.2 15 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 2.62195407367056e-08 2.50405412539141e-07 1.0234707878963 0.705882352941177 15.2 15 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 6.42086822488167e-07 3.7293450955129e-06 1.0234707878963 0.705882352941177 15.2 15 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.000426778501968628 0.00137089347246356 1.0234707878963 0.705882352941177 15.2 15 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000426778501968628 0.00137089347246356 1.0234707878963 0.705882352941177 15.2 15 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0127175613060482 0.0278047684991043 1.0234707878963 0.705882352941177 15.2 15 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0127175613060482 0.0278047684991043 1.0234707878963 0.705882352941177 15.2 15 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0127175613060482 0.0278047684991043 1.0234707878963 0.705882352941177 15.2 15 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0127175613060482 0.0278047684991043 1.0234707878963 0.705882352941177 15.2 15 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0127175613060482 0.0278047684991043 1.0234707878963 0.705882352941177 15.2 15 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 7.66074904076468e-44 3.63374862833605e-41 1.02266005374872 0.70532319391635 15.2 15 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.05115749729868e-07 7.99891507302687e-07 1.02237733619982 0.705128205128205 15.2 15 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 4.22704202475808e-07 2.54327272149577e-06 1.02106827430968 0.704225352112676 15.2 15 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.05695100106453e-05 4.85174604682204e-05 1.02031192743983 0.703703703703704 15.2 15 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00181875446855823 0.00510470928749185 1.02031192743983 0.703703703703704 15.2 15 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00181875446855823 0.00510470928749185 1.02031192743983 0.703703703703704 15.2 15 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00181875446855823 0.00510470928749185 1.02031192743983 0.703703703703704 15.2 15 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00181875446855823 0.00510470928749185 1.02031192743983 0.703703703703704 15.2 15 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00181875446855823 0.00510470928749185 1.02031192743983 0.703703703703704 15.2 15 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.70623149467688e-06 9.48424772236405e-06 1.01947285513108 0.703125 15.2 15 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.32934887120646e-05 0.000172085571053821 1.01802679434366 0.702127659574468 15.2 15 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.44718537688416e-22 6.23373223018009e-20 1.01660843587017 0.701149425287356 15.2 15 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 4.98329717911735e-09 5.86052221973883e-08 1.0164366244056 0.701030927835051 15.2 15 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000178951009557658 0.00063031506584294 1.01494186466383 0.7 15.2 15 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.00116571513543311 0.00341319472782163 1.01494186466383 0.7 15.2 15 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00797374552342337 0.0188169815585928 1.01494186466383 0.7 15.2 15 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00797374552342337 0.0188169815585928 1.01494186466383 0.7 15.2 15 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0610634124557971 0.105709532754987 1.01494186466383 0.7 15.2 15 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0610634124557971 0.105709532754987 1.01494186466383 0.7 15.2 15 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0610634124557971 0.105709532754987 1.01494186466383 0.7 15.2 15 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0610634124557971 0.105709532754987 1.01494186466383 0.7 15.2 15 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0610634124557971 0.105709532754987 1.01494186466383 0.7 15.2 15 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0610634124557971 0.105709532754987 1.01494186466383 0.7 15.2 15 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0610634124557971 0.105709532754987 1.01494186466383 0.7 15.2 15 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.33787529775001e-15 6.14127918934925e-14 1.01414956031983 0.699453551912568 15.2 15 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 7.92962041471042e-08 6.52245656077048e-07 1.01319497677284 0.698795180722892 15.2 15 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 2.96727666541287e-06 1.56386470180834e-05 1.0126404091884 0.698412698412698 15.2 15 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000116068931720911 0.000426785761857512 1.01156996478122 0.697674418604651 15.2 15 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 7.53582223225056e-05 0.000286386641986197 1.00863787792678 0.695652173913043 15.2 15 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.03300387156034e-14 3.76913976725734e-13 1.00756940559847 0.694915254237288 15.2 15 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.000482230140862832 0.00153859527006235 1.00688677049983 0.694444444444444 15.2 15 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.05972748250997e-14 1.13274357011994e-12 1.00641294143136 0.694117647058824 15.2 15 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 4.89717483054136e-05 0.000192504966404982 1.00606482211575 0.693877551020408 15.2 15 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 7.76389827431737e-11 1.29976791110043e-09 1.00466686265936 0.692913385826772 15.2 15 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.59035268349052e-23 4.08254491787938e-21 1.0045499684386 0.692832764505119 15.2 15 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 6.95236783463852e-14 1.90254219782512e-12 1.00378865735983 0.692307692307692 15.2 15 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 3.18515263037306e-05 0.000131376005594808 1.00378865735983 0.692307692307692 15.2 15 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 3.18515263037306e-05 0.000131376005594808 1.00378865735983 0.692307692307692 15.2 15 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000311067666828533 0.00106406079302164 1.00378865735983 0.692307692307692 15.2 15 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00319176536027462 0.0082881060358956 1.00378865735983 0.692307692307692 15.2 15 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0367752093530189 0.0679624972848648 1.00378865735983 0.692307692307692 15.2 15 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0367752093530189 0.0679624972848648 1.00378865735983 0.692307692307692 15.2 15 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0367752093530189 0.0679624972848648 1.00378865735983 0.692307692307692 15.2 15 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0367752093530189 0.0679624972848648 1.00378865735983 0.692307692307692 15.2 15 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.3515430948848e-07 1.50065715425762e-06 1.00241171818649 0.691358024691358 15.2 15 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.3515430948848e-07 1.50065715425762e-06 1.00241171818649 0.691358024691358 15.2 15 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.0732713762699e-05 9.07773897979099e-05 1.00176080148637 0.690909090909091 15.2 15 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.0732713762699e-05 9.07773897979099e-05 1.00176080148637 0.690909090909091 15.2 15 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 2.0732713762699e-05 9.07773897979099e-05 1.00176080148637 0.690909090909091 15.2 15 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.0732713762699e-05 9.07773897979099e-05 1.00176080148637 0.690909090909091 15.2 15 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 2.0732713762699e-05 9.07773897979099e-05 1.00176080148637 0.690909090909091 15.2 15 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000200988532902269 0.000702719121179185 1.00113313181126 0.69047619047619 15.2 15 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0225454365891934 0.0457662714214297 0.996817902794829 0.6875 15.2 15 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0225454365891934 0.0457662714214297 0.996817902794829 0.6875 15.2 15 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0225454365891934 0.0457662714214297 0.996817902794829 0.6875 15.2 15 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0225454365891934 0.0457662714214297 0.996817902794829 0.6875 15.2 15 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0225454365891934 0.0457662714214297 0.996817902794829 0.6875 15.2 15 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.74698764232187e-06 1.91797245144749e-05 0.995465368326994 0.686567164179104 15.2 15 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 5.46612218323551e-05 0.000211942557676952 0.995041043788065 0.686274509803922 15.2 15 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.44660979092957e-06 1.32882661545526e-05 0.994228765384973 0.685714285714286 15.2 15 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.000832996992877571 0.00252740878649208 0.994228765384973 0.685714285714286 15.2 15 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.84201672655779e-10 5.63627814628014e-09 0.993894683138539 0.685483870967742 15.2 15 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.84201672655779e-10 5.63627814628014e-09 0.993894683138539 0.685483870967742 15.2 15 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.84201672655779e-10 5.63627814628014e-09 0.993894683138539 0.685483870967742 15.2 15 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.83881745376471e-11 3.35466312398357e-10 0.993649377992557 0.685314685314685 15.2 15 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.54954847450451e-05 0.000143903346986323 0.99346161355983 0.685185185185185 15.2 15 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.04462064143927e-06 5.9939321482584e-06 0.992048439145093 0.684210526315789 15.2 15 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0139908544066115 0.030084772973617 0.992048439145093 0.684210526315789 15.2 15 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0139908544066115 0.030084772973617 0.992048439145093 0.684210526315789 15.2 15 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.27191723415639e-12 4.82528093164857e-11 0.991082471823628 0.683544303797468 15.2 15 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000344752177659099 0.00117364198279641 0.990187185037879 0.682926829268293 15.2 15 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 9.77259042648498e-06 4.51506369379484e-05 0.989625854434116 0.682539682539683 15.2 15 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 8.98944505069092e-09 9.56237294964692e-08 0.989195675840578 0.682242990654206 15.2 15 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 8.98944505069092e-09 9.56237294964692e-08 0.989195675840578 0.682242990654206 15.2 15 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00875958436125438 0.0205352364844563 0.988579738308922 0.681818181818182 15.2 15 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00875958436125438 0.0205352364844563 0.988579738308922 0.681818181818182 15.2 15 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00875958436125438 0.0205352364844563 0.988579738308922 0.681818181818182 15.2 15 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00875958436125438 0.0205352364844563 0.988579738308922 0.681818181818182 15.2 15 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.15147579271577e-06 2.1023309797276e-05 0.987624588803309 0.681159420289855 15.2 15 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.15147579271577e-06 2.1023309797276e-05 0.987624588803309 0.681159420289855 15.2 15 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.65896282731026e-12 3.64733755841335e-11 0.987366757034923 0.680981595092024 15.2 15 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.70838277162053e-06 1.43807040448359e-05 0.986749035089831 0.680555555555556 15.2 15 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.70838277162053e-06 1.43807040448359e-05 0.986749035089831 0.680555555555556 15.2 15 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.70838277162053e-06 1.43807040448359e-05 0.986749035089831 0.680555555555556 15.2 15 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 3.52425085153162e-08 3.15409368662232e-07 0.985943525673431 0.68 15.2 15 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00552159966066187 0.013617393963816 0.985943525673431 0.68 15.2 15 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 6.03020090230177e-05 0.000233178692499332 0.984849248730397 0.679245283018868 15.2 15 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 3.91255782629155e-05 0.000156832951741208 0.983872215745546 0.678571428571429 15.2 15 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00349920120026423 0.0090042736129765 0.983872215745546 0.678571428571429 15.2 15 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00222717346500324 0.00603670064895164 0.98220180451338 0.67741935483871 15.2 15 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.92097211985044e-08 5.16904498561177e-07 0.981256925432559 0.676767676767677 15.2 15 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 5.92097211985044e-08 5.16904498561177e-07 0.981256925432559 0.676767676767677 15.2 15 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 4.56170319422076e-06 2.27416760142229e-05 0.980225543337297 0.676056338028169 15.2 15 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.66579416098993e-08 1.65763992383823e-07 0.980036456619832 0.675925925925926 15.2 15 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00091146617090885 0.00270775858288788 0.979673614540373 0.675675675675676 15.2 15 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000585463801160349 0.00183505504196295 0.978693940925833 0.675 15.2 15 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000585463801160349 0.00183505504196295 0.978693940925833 0.675 15.2 15 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.02145052394976e-09 2.66344823664863e-08 0.978399242358857 0.67479674796748 15.2 15 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00037689342106365 0.0012666373869591 0.977850965955181 0.674418604651163 15.2 15 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.000243092489105676 0.000841655990261259 0.977117944241572 0.673913043478261 15.2 15 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.97920901050541e-11 3.56508154677113e-10 0.975905639099833 0.673076923076923 15.2 15 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.7830932213673e-15 7.68891410304748e-14 0.975398675131469 0.672727272727273 15.2 15 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 6.58411806532008e-05 0.000253907859266951 0.975398675131469 0.672727272727273 15.2 15 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 4.27091705799512e-05 0.000170238514664623 0.974944155711557 0.672413793103448 15.2 15 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 4.27091705799512e-05 0.000170238514664623 0.974944155711557 0.672413793103448 15.2 15 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 2.7733707213525e-05 0.000115394927967386 0.974534343119833 0.672131147540984 15.2 15 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.7733707213525e-05 0.000115394927967386 0.974534343119833 0.672131147540984 15.2 15 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 2.7733707213525e-05 0.000115394927967386 0.974534343119833 0.672131147540984 15.2 15 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.8026572263365e-05 8.04132047986472e-05 0.974162950458583 0.671875 15.2 15 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.97477487650007e-06 2.45802244765958e-05 0.973231925020107 0.671232876712329 15.2 15 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.11595955546685e-06 1.16255229630476e-05 0.972729092715783 0.670886075949367 15.2 15 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000109915057578963 0.000405204992059234 0.966611299679835 0.666666666666667 15.2 15 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00240041894939673 0.00643276113934377 0.966611299679835 0.666666666666667 15.2 15 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00240041894939673 0.00643276113934377 0.966611299679835 0.666666666666667 15.2 15 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00593778714370745 0.0144810364836473 0.966611299679835 0.666666666666667 15.2 15 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0391028530546021 0.0716130758001271 0.966611299679835 0.666666666666667 15.2 15 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0391028530546021 0.0716130758001271 0.966611299679835 0.666666666666667 15.2 15 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0391028530546021 0.0716130758001271 0.966611299679835 0.666666666666667 15.2 15 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.09374069926729e-14 8.80478603011471e-13 0.966611299679834 0.666666666666667 15.2 15 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 3.28390675291236e-08 2.95759449961664e-07 0.966611299679834 0.666666666666667 15.2 15 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 9.77356096389439e-07 5.63067904923956e-06 0.966611299679834 0.666666666666667 15.2 15 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 9.77356096389439e-07 5.63067904923956e-06 0.966611299679834 0.666666666666667 15.2 15 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000262759302370482 0.000905342584196602 0.966611299679834 0.666666666666667 15.2 15 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000262759302370482 0.000905342584196602 0.966611299679834 0.666666666666667 15.2 15 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00940459843191506 0.0217605586481547 0.966611299679834 0.666666666666667 15.2 15 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0149885675663365 0.0318815121777233 0.966611299679834 0.666666666666667 15.2 15 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0240801816160095 0.0483984441237027 0.966611299679834 0.666666666666667 15.2 15 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0240801816160095 0.0483984441237027 0.966611299679834 0.666666666666667 15.2 15 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0240801816160095 0.0483984441237027 0.966611299679834 0.666666666666667 15.2 15 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0240801816160095 0.0483984441237027 0.966611299679834 0.666666666666667 15.2 15 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0240801816160095 0.0483984441237027 0.966611299679834 0.666666666666667 15.2 15 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0240801816160095 0.0483984441237027 0.966611299679834 0.666666666666667 15.2 15 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0240801816160095 0.0483984441237027 0.966611299679834 0.666666666666667 15.2 15 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0644610123601199 0.110648999503559 0.966611299679834 0.666666666666667 15.2 15 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0644610123601199 0.110648999503559 0.966611299679834 0.666666666666667 15.2 15 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0644610123601199 0.110648999503559 0.966611299679834 0.666666666666667 15.2 15 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0644610123601199 0.110648999503559 0.966611299679834 0.666666666666667 15.2 15 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0644610123601199 0.110648999503559 0.966611299679834 0.666666666666667 15.2 15 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0644610123601199 0.110648999503559 0.966611299679834 0.666666666666667 15.2 15 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.108719018561526 0.17025638820134 0.966611299679834 0.666666666666667 15.2 15 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.52267921286801e-08 1.53671809922778e-07 0.962549907664373 0.663865546218487 15.2 15 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.50123173635307e-07 2.68002207566126e-06 0.961523871786783 0.663157894736842 15.2 15 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.50123173635307e-07 2.68002207566126e-06 0.961523871786783 0.663157894736842 15.2 15 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.3942370863412e-12 5.01029319685812e-11 0.961357977398966 0.66304347826087 15.2 15 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 8.89513308651214e-06 4.15008996134649e-05 0.960080142249565 0.662162162162162 15.2 15 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 8.89513308651214e-06 4.15008996134649e-05 0.960080142249565 0.662162162162162 15.2 15 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.03249345954504e-09 3.6569815194344e-08 0.959343545546903 0.661654135338346 15.2 15 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 7.04426107487448e-09 7.83123711683311e-08 0.95900018708393 0.661417322834646 15.2 15 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 4.9625056084159e-05 0.000194535688175642 0.958816047263062 0.661290322580645 15.2 15 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 7.64380572768369e-05 0.000287754908743225 0.958419678496107 0.661016949152542 15.2 15 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 7.64380572768369e-05 0.000287754908743225 0.958419678496107 0.661016949152542 15.2 15 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 5.81362308795854e-08 5.13837618271118e-07 0.957980841646979 0.660714285714286 15.2 15 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 4.04922763809933e-06 2.06525122903776e-05 0.954823357000812 0.658536585365854 15.2 15 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 9.51193376322375e-06 4.40895170849101e-05 0.953892729947205 0.657894736842105 15.2 15 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.50264131455164e-12 8.6584575548743e-11 0.953688688721548 0.657754010695187 15.2 15 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00628492736362428 0.0152879515186963 0.949945587616389 0.655172413793103 15.2 15 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.31244857157738e-06 2.16841495312884e-05 0.949350383614123 0.654761904761905 15.2 15 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.31244857157738e-06 2.16841495312884e-05 0.949350383614123 0.654761904761905 15.2 15 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.54352383931827e-07 1.07668354085779e-06 0.949036548776565 0.654545454545455 15.2 15 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00992239778361555 0.0226275193046233 0.948022620839837 0.653846153846154 15.2 15 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 7.15526065249101e-13 1.66916982106471e-11 0.945898200400981 0.652380952380952 15.2 15 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000714964235262243 0.00222732481754171 0.94559801055636 0.652173913043478 15.2 15 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0157490007042055 0.0333991475440901 0.94559801055636 0.652173913043478 15.2 15 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.64977288924815e-05 0.000147546216517049 0.94559801055636 0.652173913043478 15.2 15 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.57070930433433e-06 2.27416760142229e-05 0.944131967129141 0.651162790697674 15.2 15 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00110900008657643 0.00326055190743443 0.944131967129141 0.651162790697674 15.2 15 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0251654851896752 0.0499448890166078 0.942446017187839 0.65 15.2 15 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0251654851896752 0.0499448890166078 0.942446017187839 0.65 15.2 15 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0251654851896752 0.0499448890166078 0.942446017187839 0.65 15.2 15 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0251654851896752 0.0499448890166078 0.942446017187839 0.65 15.2 15 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0251654851896752 0.0499448890166078 0.942446017187839 0.65 15.2 15 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0251654851896752 0.0499448890166078 0.942446017187839 0.65 15.2 15 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0251654851896752 0.0499448890166078 0.942446017187839 0.65 15.2 15 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0251654851896752 0.0499448890166078 0.942446017187839 0.65 15.2 15 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.73276963256328e-07 1.20279570104271e-06 0.941174160214576 0.649122807017544 15.2 15 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00268480366798068 0.00710125579839499 0.940486669958758 0.648648648648649 15.2 15 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00268480366798068 0.00710125579839499 0.940486669958758 0.648648648648649 15.2 15 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.8453994865358e-48 2.73600173467022e-45 0.939821733116309 0.648190045248869 15.2 15 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00419301961697678 0.0107314153146726 0.938181555571604 0.647058823529412 15.2 15 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0405632079416262 0.0740968483965778 0.938181555571604 0.647058823529412 15.2 15 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0405632079416262 0.0740968483965778 0.938181555571604 0.647058823529412 15.2 15 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.54479372922857e-14 4.78274709357941e-13 0.937843106236982 0.646825396825397 15.2 15 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.54479372922857e-14 4.78274709357941e-13 0.937843106236982 0.646825396825397 15.2 15 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.54479372922857e-14 4.78274709357941e-13 0.937843106236982 0.646825396825397 15.2 15 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.72389495617947e-05 7.71415887623704e-05 0.936022334500093 0.645569620253165 15.2 15 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 4.23580910045326e-07 2.54327272149577e-06 0.935855485599112 0.645454545454546 15.2 15 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00656853991722777 0.0159233940412523 0.935430290012743 0.645161290322581 15.2 15 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00656853991722777 0.0159233940412523 0.935430290012743 0.645161290322581 15.2 15 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00116174532890412 0.00340858474851663 0.93439092302384 0.644444444444444 15.2 15 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00180103836924479 0.00510470928749185 0.932089467548412 0.642857142857143 15.2 15 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00180103836924479 0.00510470928749185 0.932089467548412 0.642857142857143 15.2 15 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0661513395856781 0.113413682205325 0.932089467548412 0.642857142857143 15.2 15 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.47911532883941e-06 1.80028404106854e-05 0.930999304428472 0.642105263157895 15.2 15 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 9.48344903457226e-05 0.000354198109611452 0.930543713870885 0.641791044776119 15.2 15 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000782474870925526 0.00237919175497227 0.927946847692641 0.64 15.2 15 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0163077073585874 0.0345325410286753 0.927946847692641 0.64 15.2 15 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 5.60674137905738e-09 6.4864983596737e-08 0.926075987112616 0.638709677419355 15.2 15 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 5.60674137905738e-09 6.4864983596737e-08 0.926075987112616 0.638709677419355 15.2 15 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.28372295077805e-05 5.85492871460629e-05 0.92267442242166 0.636363636363636 15.2 15 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0258892881752303 0.0512384660269162 0.92267442242166 0.636363636363636 15.2 15 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.109686491723164 0.170397246421466 0.92267442242166 0.636363636363636 15.2 15 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.109686491723164 0.170397246421466 0.92267442242166 0.636363636363636 15.2 15 2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.109686491723164 0.170397246421466 0.92267442242166 0.636363636363636 15.2 15 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.109686491723164 0.170397246421466 0.92267442242166 0.636363636363636 15.2 15 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.109686491723164 0.170397246421466 0.92267442242166 0.636363636363636 15.2 15 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.109686491723164 0.170397246421466 0.92267442242166 0.636363636363636 15.2 15 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.109686491723164 0.170397246421466 0.92267442242166 0.636363636363636 15.2 15 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.64486801757749e-10 2.65982635115087e-09 0.921301395007342 0.635416666666667 15.2 15 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.90224261241306e-38 8.25978247492756e-36 0.920817934650188 0.635083226632522 15.2 15 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.58147880258127e-06 1.39145618790649e-05 0.920139602579842 0.634615384615385 15.2 15 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0106329375037208 0.0240934236748322 0.918280734695843 0.633333333333333 15.2 15 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0106329375037208 0.0240934236748322 0.918280734695843 0.633333333333333 15.2 15 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0106329375037208 0.0240934236748322 0.918280734695843 0.633333333333333 15.2 15 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.02495739204416e-05 9.00473240274638e-05 0.916614163489498 0.632183908045977 15.2 15 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 6.92745610984984e-05 0.000266426217413955 0.915737020749317 0.631578947368421 15.2 15 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00448474769411371 0.0113152410792975 0.915737020749317 0.631578947368421 15.2 15 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0413761711178347 0.0752919328653182 0.915737020749317 0.631578947368421 15.2 15 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0413761711178347 0.0752919328653182 0.915737020749317 0.631578947368421 15.2 15 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00192390131217558 0.00535755688302513 0.914078076871148 0.630434782608696 15.2 15 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0166962358714594 0.0351460704808975 0.912910671919844 0.62962962962963 15.2 15 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0166962358714594 0.0351460704808975 0.912910671919844 0.62962962962963 15.2 15 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0166962358714594 0.0351460704808975 0.912910671919844 0.62962962962963 15.2 15 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0166962358714594 0.0351460704808975 0.912910671919844 0.62962962962963 15.2 15 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00696881030047723 0.0166665832900489 0.911376368269558 0.628571428571429 15.2 15 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00696881030047723 0.0166665832900489 0.911376368269558 0.628571428571429 15.2 15 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00696881030047723 0.0166665832900489 0.911376368269558 0.628571428571429 15.2 15 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.77553511416738e-24 2.10548872288348e-22 0.906876893519845 0.625468164794007 15.2 15 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.000165362816579612 0.000586811192001964 0.906198093449845 0.625 15.2 15 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0666985471636165 0.113434743084159 0.906198093449845 0.625 15.2 15 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.186561328491489 0.266272034500108 0.906198093449845 0.625 15.2 15 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.186561328491489 0.266272034500108 0.906198093449845 0.625 15.2 15 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.186561328491489 0.266272034500108 0.906198093449845 0.625 15.2 15 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.186561328491489 0.266272034500108 0.906198093449845 0.625 15.2 15 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.186561328491489 0.266272034500108 0.906198093449845 0.625 15.2 15 2 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.186561328491489 0.266272034500108 0.906198093449845 0.625 15.2 15 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.186561328491489 0.266272034500108 0.906198093449845 0.625 15.2 15 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0263230044913562 0.0519523375744797 0.906198093449845 0.625 15.2 15 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0263230044913562 0.0519523375744797 0.906198093449845 0.625 15.2 15 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000873749755899553 0.00261757032135803 0.899948451426053 0.620689655172414 15.2 15 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000873749755899553 0.00261757032135803 0.899948451426053 0.620689655172414 15.2 15 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000873749755899553 0.00261757032135803 0.899948451426053 0.620689655172414 15.2 15 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0169419382609103 0.0355580798602881 0.899948451426053 0.620689655172414 15.2 15 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0169419382609103 0.0355580798602881 0.899948451426053 0.620689655172414 15.2 15 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.52458420720106e-09 3.15130116390098e-08 0.898646442671096 0.619791666666667 15.2 15 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0417029763276004 0.0756930297374687 0.897567635416989 0.619047619047619 15.2 15 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0417029763276004 0.0756930297374687 0.897567635416989 0.619047619047619 15.2 15 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000172420000733437 0.000610332490158412 0.896659166150373 0.618421052631579 15.2 15 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0109969792773146 0.024839208748601 0.895536939409258 0.617647058823529 15.2 15 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 6.21637441806913e-08 5.39384194933681e-07 0.892936657935945 0.615853658536585 15.2 15 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00203703856854019 0.00557504505209229 0.892256584319847 0.615384615384615 15.2 15 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0071845185451233 0.0170392831495174 0.892256584319847 0.615384615384615 15.2 15 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0265242026785422 0.0520606074642284 0.892256584319847 0.615384615384615 15.2 15 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0265242026785422 0.0520606074642284 0.892256584319847 0.615384615384615 15.2 15 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0265242026785422 0.0520606074642284 0.892256584319847 0.615384615384615 15.2 15 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.108758297171482 0.17025638820134 0.892256584319847 0.615384615384615 15.2 15 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.108758297171482 0.17025638820134 0.892256584319847 0.615384615384615 15.2 15 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.108758297171482 0.17025638820134 0.892256584319847 0.615384615384615 15.2 15 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.108758297171482 0.17025638820134 0.892256584319847 0.615384615384615 15.2 15 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.108758297171482 0.17025638820134 0.892256584319847 0.615384615384615 15.2 15 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.24401863746257e-06 1.69714651511369e-05 0.891342386999847 0.614754098360656 15.2 15 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.29354707950515e-06 1.71674633484829e-05 0.888658775512106 0.612903225806452 15.2 15 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0170682336823345 0.035770392533081 0.888658775512106 0.612903225806452 15.2 15 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00311093796397675 0.00813221634876642 0.887704254808011 0.612244897959184 15.2 15 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.93947300221049e-06 2.44908365231552e-05 0.886726068301336 0.611570247933884 15.2 15 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00723614709565496 0.0171331735725741 0.884095700926678 0.609756097560976 15.2 15 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.00137522861542846 0.00400194339418138 0.879457821839849 0.60655737704918 15.2 15 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0170950388690029 0.0357738828096929 0.878737545163486 0.606060606060606 15.2 15 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 5.16985490852314e-06 2.53679432235463e-05 0.874377397038629 0.603053435114504 15.2 15 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 5.16985490852314e-06 2.53679432235463e-05 0.874377397038629 0.603053435114504 15.2 15 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.31464550322536e-55 1.87074055108969e-52 0.872383858587739 0.601678502259522 15.2 15 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.35870536470103e-12 3.06894878407866e-11 0.871729208913716 0.601226993865031 15.2 15 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0110806918329077 0.0249839274155226 0.869950169711851 0.6 15.2 15 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.18020242772012 0.264905015129888 0.869950169711851 0.6 15.2 15 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.18020242772012 0.264905015129888 0.869950169711851 0.6 15.2 15 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.18020242772012 0.264905015129888 0.869950169711851 0.6 15.2 15 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.18020242772012 0.264905015129888 0.869950169711851 0.6 15.2 15 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.18020242772012 0.264905015129888 0.869950169711851 0.6 15.2 15 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0264054393966947 0.0520428535477792 0.869950169711851 0.6 15.2 15 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.106724069382292 0.170065342363943 0.869950169711851 0.6 15.2 15 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 3.8106530551207e-18 2.25939970726531e-16 0.869950169711851 0.6 15.2 15 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000920039915796493 0.00272753500037169 0.869950169711851 0.6 15.2 15 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0031449397158644 0.00818144280744981 0.869950169711851 0.6 15.2 15 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 5.23514540677547e-06 2.56000409410361e-05 0.863780310352192 0.595744680851064 15.2 15 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.58628947920346e-21 1.25404996050362e-19 0.85912652840906 0.59253499222395 15.2 15 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00205814041775259 0.00558918666882048 0.856769106534399 0.590909090909091 15.2 15 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 9.77133675986311e-10 1.34996235041604e-08 0.853200226612706 0.588447653429603 15.2 15 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.025806552571415 0.0511458555837376 0.852892323246913 0.588235294117647 15.2 15 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.104034746052174 0.166488362166209 0.852892323246913 0.588235294117647 15.2 15 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.104034746052174 0.166488362166209 0.852892323246913 0.588235294117647 15.2 15 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.104034746052174 0.166488362166209 0.852892323246913 0.588235294117647 15.2 15 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00202208809376692 0.00555488679040605 0.849237070432997 0.585714285714286 15.2 15 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.6429799045983e-14 7.83533417550703e-13 0.84849399960685 0.585201793721973 15.2 15 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000396855388333283 0.00128932698081795 0.848355661953046 0.585106382978723 15.2 15 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0106509890796004 0.0240959578064728 0.845784887219855 0.583333333333333 15.2 15 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.173002162831427 0.255906525685157 0.845784887219855 0.583333333333333 15.2 15 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.173002162831427 0.255906525685157 0.845784887219855 0.583333333333333 15.2 15 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.173002162831427 0.255906525685157 0.845784887219855 0.583333333333333 15.2 15 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.0029593438716332 0.0077553339398417 0.840531564938986 0.579710144927536 15.2 15 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 6.43582887528205e-17 3.39192018130606e-15 0.840494764082378 0.57968476357268 15.2 15 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0249073550883328 0.0499448890166078 0.83942560235354 0.578947368421053 15.2 15 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 2.13055950210076e-06 1.16607160441899e-05 0.838600614046559 0.578378378378378 15.2 15 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.000373260481172166 0.00126163815845129 0.836490547799857 0.576923076923077 15.2 15 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0615574240704653 0.106435254498508 0.836490547799857 0.576923076923077 15.2 15 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0384460593266573 0.0706831297439708 0.834800667905312 0.575757575757576 15.2 15 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0384460593266573 0.0706831297439708 0.834800667905312 0.575757575757576 15.2 15 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0384460593266573 0.0706831297439708 0.834800667905312 0.575757575757576 15.2 15 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 2.1275756524529e-05 9.22501533362253e-05 0.831162582527246 0.573248407643312 15.2 15 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0374963123432074 0.0692052561146357 0.828523971154144 0.571428571428571 15.2 15 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.059859694432943 0.104772872297759 0.828523971154144 0.571428571428571 15.2 15 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.165567573952553 0.247467461609364 0.828523971154144 0.571428571428571 15.2 15 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.165567573952553 0.247467461609364 0.828523971154144 0.571428571428571 15.2 15 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.165567573952553 0.247467461609364 0.828523971154144 0.571428571428571 15.2 15 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.165567573952553 0.247467461609364 0.828523971154144 0.571428571428571 15.2 15 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0976778315867055 0.157949493577139 0.828523971154144 0.571428571428571 15.2 15 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.64175004574372e-13 4.17180413409521e-12 0.828102973201322 0.571138211382114 15.2 15 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000516908219983956 0.00164554898666033 0.826588167483223 0.570093457943925 15.2 15 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00265193877845396 0.00704050164503728 0.823409625653192 0.567901234567901 15.2 15 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0580899296836149 0.101800455590867 0.821619604727859 0.566666666666667 15.2 15 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0942914424571501 0.152820868583741 0.819518275815512 0.565217391304348 15.2 15 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.86158040612299e-24 4.22694532147155e-22 0.8185717312604 0.564564564564565 15.2 15 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.158185455092017 0.242301294505856 0.81557828410486 0.5625 15.2 15 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.158185455092017 0.242301294505856 0.81557828410486 0.5625 15.2 15 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0138440781893645 0.030084772973617 0.813988462888282 0.56140350877193 15.2 15 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 5.41216581825716e-05 0.000210423824026774 0.813368044852544 0.560975609756098 15.2 15 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.034448009942141 0.0640778015002179 0.813368044852544 0.560975609756098 15.2 15 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0544561012166312 0.0966989237254067 0.810247707084567 0.558823529411765 15.2 15 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0130940551263695 0.0285779761423677 0.808150430879861 0.557377049180328 15.2 15 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0127202419486415 0.0278047684991043 0.805509416399862 0.555555555555556 15.2 15 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0874799202520368 0.144917260207972 0.805509416399862 0.555555555555556 15.2 15 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0874799202520368 0.144917260207972 0.805509416399862 0.555555555555556 15.2 15 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0874799202520368 0.144917260207972 0.805509416399862 0.555555555555556 15.2 15 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.150996795550754 0.232039352126051 0.805509416399862 0.555555555555556 15.2 15 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.283864215903942 0.384337563493158 0.805509416399862 0.555555555555556 15.2 15 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.283864215903942 0.384337563493158 0.805509416399862 0.555555555555556 15.2 15 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.283864215903942 0.384337563493158 0.805509416399862 0.555555555555556 15.2 15 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.283864215903942 0.384337563493158 0.805509416399862 0.555555555555556 15.2 15 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0508288598881554 0.0906384306025628 0.801269893155652 0.552631578947368 15.2 15 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0841357673501733 0.139865884274879 0.79995417904538 0.551724137931034 15.2 15 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0116193612477251 0.0256346527992447 0.798504986692037 0.550724637681159 15.2 15 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0273539820242508 0.0534371919215105 0.790863790647137 0.545454545454545 15.2 15 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.13743726510019 0.212118468804307 0.790863790647137 0.545454545454545 15.2 15 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.264821550916468 0.360613461200128 0.790863790647137 0.545454545454545 15.2 15 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.264821550916468 0.360613461200128 0.790863790647137 0.545454545454545 15.2 15 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.264821550916468 0.360613461200128 0.790863790647137 0.545454545454545 15.2 15 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.264821550916468 0.360613461200128 0.790863790647137 0.545454545454545 15.2 15 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.264821550916468 0.360613461200128 0.790863790647137 0.545454545454545 15.2 15 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.264821550916468 0.360613461200128 0.790863790647137 0.545454545454545 15.2 15 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.264821550916468 0.360613461200128 0.790863790647137 0.545454545454545 15.2 15 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 6.57454214092197e-06 3.13945418339999e-05 0.790346886208806 0.545098039215686 15.2 15 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00957949980927266 0.022129266604862 0.787609207146532 0.54320987654321 15.2 15 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0716114117831386 0.119324401601178 0.783738891632298 0.540540540540541 15.2 15 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0407473035190179 0.0743377088558494 0.782955152740666 0.54 15.2 15 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.125080938533193 0.193889080101017 0.780724511279866 0.538461538461538 15.2 15 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.247953339434697 0.340248410815404 0.780724511279866 0.538461538461538 15.2 15 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.247953339434697 0.340248410815404 0.780724511279866 0.538461538461538 15.2 15 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.247953339434697 0.340248410815404 0.780724511279866 0.538461538461538 15.2 15 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.247953339434697 0.340248410815404 0.780724511279866 0.538461538461538 15.2 15 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.11934941158176 0.185206338801358 0.77674122295701 0.535714285714286 15.2 15 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.232817293461422 0.32102617111977 0.773289039743868 0.533333333333333 15.2 15 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.108727540223075 0.17025638820134 0.770268379432368 0.53125 15.2 15 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.219105002761841 0.302999435306219 0.767603090922221 0.529411764705882 15.2 15 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.219105002761841 0.302999435306219 0.767603090922221 0.529411764705882 15.2 15 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.219105002761841 0.302999435306219 0.767603090922221 0.529411764705882 15.2 15 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.219105002761841 0.302999435306219 0.767603090922221 0.529411764705882 15.2 15 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.206590576674273 0.287088272077627 0.763114183957764 0.526315789473684 15.2 15 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.206590576674273 0.287088272077627 0.763114183957764 0.526315789473684 15.2 15 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.184505435256234 0.266272034500108 0.756478408445088 0.521739130434783 15.2 15 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.174692237472608 0.258138166068039 0.753956813750271 0.52 15.2 15 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.149142229651251 0.229437181398628 0.748344232010194 0.516129032258065 15.2 15 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0960909834688618 0.155560261065063 0.739753545673343 0.510204081632653 15.2 15 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00294381703929307 0.00772887757733218 0.735998451532869 0.50761421319797 15.2 15 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0364445048310147 0.0677030422644045 0.732753727176649 0.505376344086022 15.2 15 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.1321642110864 0.204201598670952 0.724958474759876 0.5 15.2 15 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.200254193262109 0.278827511753406 0.724958474759876 0.5 15.2 15 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.200254193262109 0.278827511753406 0.724958474759876 0.5 15.2 15 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.387526004087763 0.487146204785235 0.724958474759876 0.5 15.2 15 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.387526004087763 0.487146204785235 0.724958474759876 0.5 15.2 15 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.387526004087763 0.487146204785235 0.724958474759876 0.5 15.2 15 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.387526004087763 0.487146204785235 0.724958474759876 0.5 15.2 15 2 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.387526004087763 0.487146204785235 0.724958474759876 0.5 15.2 15 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.387526004087763 0.487146204785235 0.724958474759876 0.5 15.2 15 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.387526004087763 0.487146204785235 0.724958474759876 0.5 15.2 15 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0507298901768801 0.0905754500899628 0.724958474759876 0.5 15.2 15 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.189556919079428 0.266272034500108 0.724958474759876 0.5 15.2 15 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.189556919079428 0.266272034500108 0.724958474759876 0.5 15.2 15 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.252767209060163 0.346519979279973 0.724958474759876 0.5 15.2 15 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.307449131830826 0.409644302055492 0.724958474759876 0.5 15.2 15 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.307449131830826 0.409644302055492 0.724958474759876 0.5 15.2 15 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.307449131830826 0.409644302055492 0.724958474759876 0.5 15.2 15 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.330339104916841 0.431787959854273 0.724958474759876 0.5 15.2 15 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.330339104916841 0.431787959854273 0.724958474759876 0.5 15.2 15 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.12584652045718 0.194651737620182 0.724958474759876 0.5 15.2 15 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.12584652045718 0.194651737620182 0.724958474759876 0.5 15.2 15 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.237903092537919 0.327721297852331 0.724958474759876 0.5 15.2 15 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.356640939001508 0.460588801569161 0.724958474759876 0.5 15.2 15 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.356640939001508 0.460588801569161 0.724958474759876 0.5 15.2 15 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.356640939001508 0.460588801569161 0.724958474759876 0.5 15.2 15 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.170699427095811 0.253290182228717 0.708848286431878 0.488888888888889 15.2 15 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.0103710245685419 0.0236127487376562 0.70317860641945 0.484978540772532 15.2 15 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.100403364482683 0.161988648139294 0.699371705062468 0.482352941176471 15.2 15 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.100403364482683 0.161988648139294 0.699371705062468 0.482352941176471 15.2 15 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.315340501713765 0.419765700597463 0.693438541074664 0.478260869565217 15.2 15 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0563521578793243 0.0988768442198255 0.684930092717919 0.47239263803681 15.2 15 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0609354386199739 0.105709532754987 0.683923089396109 0.471698113207547 15.2 15 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0609354386199739 0.105709532754987 0.683923089396109 0.471698113207547 15.2 15 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.385977246558813 0.487146204785235 0.68231385859753 0.470588235294118 15.2 15 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.194514005430596 0.271366107576214 0.679648570087384 0.46875 15.2 15 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.415670689940333 0.512120685528219 0.676627909775884 0.466666666666667 15.2 15 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0796015526464187 0.132483051948367 0.6754271503974 0.46583850931677 15.2 15 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.161692699150084 0.247407216011366 0.671540481882832 0.463157894736842 15.2 15 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0903223694452016 0.149452013628514 0.671257846999885 0.462962962962963 15.2 15 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0436917684569271 0.0792017662601367 0.670941960954238 0.462745098039216 15.2 15 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.357921320757789 0.460588801569161 0.669192438239885 0.461538461538462 15.2 15 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.449801738630202 0.548943288225367 0.669192438239885 0.461538461538462 15.2 15 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.449801738630202 0.548943288225367 0.669192438239885 0.461538461538462 15.2 15 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.30029258370615 0.405039191103177 0.661918607389452 0.456521739130435 15.2 15 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.406077880993561 0.504197930381965 0.659053158872614 0.454545454545455 15.2 15 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.489779715063843 0.588148974291855 0.659053158872614 0.454545454545455 15.2 15 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.284976644717876 0.385476963339864 0.659053158872614 0.454545454545455 15.2 15 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.153690517432986 0.235924062898747 0.65480120300892 0.451612903225806 15.2 15 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.433952260852575 0.530966523811879 0.652462627283888 0.45 15.2 15 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.340638847017071 0.443079597171199 0.64440753311989 0.444444444444444 15.2 15 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.362703571641714 0.460588801569161 0.64440753311989 0.444444444444444 15.2 15 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.218138820624878 0.302840528535806 0.643273012815101 0.443661971830986 15.2 15 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.225856443456351 0.31173008636119 0.642106077644461 0.442857142857143 15.2 15 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.410253761844915 0.505884838046199 0.639669242435185 0.441176470588235 15.2 15 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.410253761844915 0.505884838046199 0.639669242435185 0.441176470588235 15.2 15 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.29095593837243 0.393191168379837 0.637963457788691 0.44 15.2 15 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.44734601911422 0.546884351545993 0.637963457788691 0.44 15.2 15 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.265482152005999 0.360822447282269 0.635000123877263 0.437956204379562 15.2 15 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.265482152005999 0.360822447282269 0.635000123877263 0.437956204379562 15.2 15 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.499843012914394 0.599727324938603 0.634338665414891 0.4375 15.2 15 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.421240386280345 0.518533797298384 0.632015080559892 0.435897435897436 15.2 15 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.146444673649474 0.225531137016452 0.631535990899067 0.435567010309278 15.2 15 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.299452227516823 0.404288918174989 0.629008088394598 0.433823529411765 15.2 15 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.350432176706748 0.455401815026213 0.628297344791892 0.433333333333333 15.2 15 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.223704545378773 0.30905977482912 0.626571253185321 0.432142857142857 15.2 15 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0136033091375223 0.0296439646289345 0.625939756256088 0.431707317073171 15.2 15 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.539398713915224 0.633826895046543 0.621392978365608 0.428571428571429 15.2 15 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.474028286977587 0.573590350654002 0.605661510558884 0.417721518987342 15.2 15 2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.584878840822654 0.685570502875318 0.604132062299896 0.416666666666667 15.2 15 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.584878840822654 0.685570502875318 0.604132062299896 0.416666666666667 15.2 15 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.554325266818794 0.650829088022396 0.591802836538674 0.408163265306122 15.2 15 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.638876349154862 0.740270779326082 0.576671514013538 0.397727272727273 15.2 15 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.630479506103451 0.735387161627222 0.571179404356266 0.393939393939394 15.2 15 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.635274038210914 0.740270779326082 0.569610230168474 0.392857142857143 15.2 15 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.836477752278834 0.924870117710008 0.547894884150321 0.377880184331797 15.2 15 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.73914333785487 0.835425710696966 0.531636214823909 0.366666666666667 15.2 15 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.741470538458332 0.836063848039783 0.51782748197134 0.357142857142857 15.2 15 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.741470538458332 0.836063848039783 0.51782748197134 0.357142857142857 15.2 15 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.741470538458332 0.836063848039783 0.51782748197134 0.357142857142857 15.2 15 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.773143864974349 0.871087664179333 0.507470932331913 0.35 15.2 15 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.874946160952985 0.958135343394186 0.499151736719914 0.344262295081967 15.2 15 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.863563315929959 0.950387160532352 0.493588748772681 0.340425531914894 15.2 15 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.801263776071588 0.887313893657486 0.483305649839917 0.333333333333333 15.2 15 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.854030525548387 0.940623403912813 0.483305649839917 0.333333333333333 15.2 15 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.820466644711168 0.907872500329698 0.483305649839917 0.333333333333333 15.2 15 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.940449465196355 1 0.477187856803969 0.329113924050633 15.2 15 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.87653426993814 0.958135343394186 0.467715145006371 0.32258064516129 15.2 15 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.870956438373237 0.957782853017864 0.466044733774206 0.321428571428571 15.2 15 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.988347032629637 1 0.439368772581743 0.303030303030303 15.2 15 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.918472763384014 0.995731581842564 0.429605022079926 0.296296296296296 15.2 15 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.937265540218327 1 0.40597674586553 0.28 15.2 15 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.91705152965212 0.99539613020211 0.402754708199931 0.277777777777778 15.2 15 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999950499666549 1 0.397557873255416 0.274193548387097 15.2 15 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.392001056041444 0.270361041141898 15.2 15 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.990104244857189 1 0.382996930061821 0.264150943396226 15.2 15 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.93946743477528 1 0.381557091978882 0.263157894736842 15.2 15 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.997838151071926 1 0.367584578751486 0.253521126760563 15.2 15 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.956269038836103 1 0.362479237379938 0.25 15.2 15 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.343470380446813 0.236889692585895 15.2 15 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.996163203371865 1 0.339342264781218 0.234042553191489 15.2 15 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.997076350822337 1 0.305245673583106 0.210526315789474 15.2 15 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.997461840056652 1 0.28998338990395 0.2 15.2 15 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.996946130481523 1 0.280629087003823 0.193548387096774 15.2 15 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.996946130481523 1 0.280629087003823 0.193548387096774 15.2 15 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.996946130481523 1 0.280629087003823 0.193548387096774 15.2 15 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.998995422048977 1 0.255867696974074 0.176470588235294 15.2 15 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999983923043 1 0.241652824919959 0.166666666666667 15.2 15 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.999918238969332 1 0.241652824919959 0.166666666666667 15.2 15 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999981173797337 1 0.211446221804964 0.145833333333333 15.2 15 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999987766293 1 0.209432448263964 0.144444444444444 15.2 15 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0116928786251593 0.00806451612903226 15.2 15 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 8.55350133174831e-06 4.71768697483637e-05 2.65560344827586 1 16.2 16 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 8.55350133174831e-06 4.71768697483637e-05 2.65560344827586 1 16.2 16 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 3.12878075029741e-05 0.000154057266701495 2.65560344827586 1 16.2 16 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 3.12878075029741e-05 0.000154057266701495 2.65560344827586 1 16.2 16 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00153061007788395 0.0045187928232964 2.65560344827586 1 16.2 16 2 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00153061007788395 0.0045187928232964 2.65560344827586 1 16.2 16 2 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.00153061007788395 0.0045187928232964 2.65560344827586 1 16.2 16 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 1.93288683481375e-05 0.000100383137443064 2.41418495297806 0.909090909090909 16.2 16 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 1.93288683481375e-05 0.000100383137443064 2.41418495297806 0.909090909090909 16.2 16 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 1.93288683481375e-05 0.000100383137443064 2.41418495297806 0.909090909090909 16.2 16 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 6.44913571883441e-05 0.000289499057662504 2.39004310344828 0.9 16.2 16 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.000696493655106376 0.00225765483192796 2.32365301724138 0.875 16.2 16 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.000696493655106376 0.00225765483192796 2.32365301724138 0.875 16.2 16 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.000696493655106376 0.00225765483192796 2.32365301724138 0.875 16.2 16 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 2.79308948438967e-06 1.6913048239517e-05 2.30152298850575 0.866666666666667 16.2 16 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00224313849440757 0.00633495550451045 2.2762315270936 0.857142857142857 16.2 16 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00224313849440757 0.00633495550451045 2.2762315270936 0.857142857142857 16.2 16 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00224313849440757 0.00633495550451045 2.2762315270936 0.857142857142857 16.2 16 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 1.24063989054134e-07 1.02048009493661e-06 2.25726293103448 0.85 16.2 16 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 8.7233739259191e-05 0.000368348993963884 2.21300287356322 0.833333333333333 16.2 16 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 8.7233739259191e-05 0.000368348993963884 2.21300287356322 0.833333333333333 16.2 16 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00709096780649802 0.0169302805178636 2.21300287356322 0.833333333333333 16.2 16 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00709096780649802 0.0169302805178636 2.21300287356322 0.833333333333333 16.2 16 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00709096780649802 0.0169302805178636 2.21300287356322 0.833333333333333 16.2 16 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00709096780649802 0.0169302805178636 2.21300287356322 0.833333333333333 16.2 16 2 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.00709096780649802 0.0169302805178636 2.21300287356322 0.833333333333333 16.2 16 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 3.6734143236847e-06 2.15113933440466e-05 2.18696754563895 0.823529411764706 16.2 16 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000267722556969274 0.000966926899916947 2.17276645768025 0.818181818181818 16.2 16 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.000267722556969274 0.000966926899916947 2.17276645768025 0.818181818181818 16.2 16 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.000267722556969274 0.000966926899916947 2.17276645768025 0.818181818181818 16.2 16 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 1.1129660560711e-05 6.04484999156174e-05 2.15767780172414 0.8125 16.2 16 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 1.1129660560711e-05 6.04484999156174e-05 2.15767780172414 0.8125 16.2 16 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 4.8383056523533e-07 3.44245447164938e-06 2.14977422003284 0.80952380952381 16.2 16 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 6.40792797092769e-08 5.77119082444943e-07 2.12448275862069 0.8 16.2 16 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 3.32942535572187e-05 0.000159520952228694 2.12448275862069 0.8 16.2 16 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000807845855610526 0.00253071639861895 2.12448275862069 0.8 16.2 16 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.000807845855610526 0.00253071639861895 2.12448275862069 0.8 16.2 16 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 9.81624537012325e-05 0.000407245398299866 2.08654556650246 0.785714285714286 16.2 16 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 9.81624537012325e-05 0.000407245398299866 2.08654556650246 0.785714285714286 16.2 16 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00238815354892396 0.00662444931797036 2.065469348659 0.777777777777778 16.2 16 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00238815354892396 0.00662444931797036 2.065469348659 0.777777777777778 16.2 16 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00238815354892396 0.00662444931797036 2.065469348659 0.777777777777778 16.2 16 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00238815354892396 0.00662444931797036 2.065469348659 0.777777777777778 16.2 16 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 2.05743819609736e-07 1.62651919613697e-06 2.04277188328913 0.769230769230769 16.2 16 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.000284604797172635 0.00101248156594165 2.04277188328913 0.769230769230769 16.2 16 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.000284604797172635 0.00101248156594165 2.04277188328913 0.769230769230769 16.2 16 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.000284604797172635 0.00101248156594165 2.04277188328913 0.769230769230769 16.2 16 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.80479241974727e-08 2.66081307553358e-07 1.9917025862069 0.75 16.2 16 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 9.9788032546742e-05 0.000409563680713081 1.9917025862069 0.75 16.2 16 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 9.9788032546742e-05 0.000409563680713081 1.9917025862069 0.75 16.2 16 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 9.9788032546742e-05 0.000409563680713081 1.9917025862069 0.75 16.2 16 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00688307301231115 0.0165729490634835 1.9917025862069 0.75 16.2 16 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00688307301231115 0.0165729490634835 1.9917025862069 0.75 16.2 16 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00688307301231115 0.0165729490634835 1.9917025862069 0.75 16.2 16 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00688307301231115 0.0165729490634835 1.9917025862069 0.75 16.2 16 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00688307301231115 0.0165729490634835 1.9917025862069 0.75 16.2 16 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.63097418052073e-06 1.0454397562527e-05 1.9917025862069 0.75 16.2 16 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 1.63097418052073e-06 1.0454397562527e-05 1.9917025862069 0.75 16.2 16 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000809189010099524 0.00253071639861895 1.9917025862069 0.75 16.2 16 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000809189010099524 0.00253071639861895 1.9917025862069 0.75 16.2 16 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000809189010099524 0.00253071639861895 1.9917025862069 0.75 16.2 16 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000809189010099524 0.00253071639861895 1.9917025862069 0.75 16.2 16 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.000809189010099524 0.00253071639861895 1.9917025862069 0.75 16.2 16 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000809189010099524 0.00253071639861895 1.9917025862069 0.75 16.2 16 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.000809189010099524 0.00253071639861895 1.9917025862069 0.75 16.2 16 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 2.11596035358318e-07 1.63641933866786e-06 1.94744252873563 0.733333333333333 16.2 16 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.11596035358318e-07 1.63641933866786e-06 1.94744252873563 0.733333333333333 16.2 16 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.11596035358318e-07 1.63641933866786e-06 1.94744252873563 0.733333333333333 16.2 16 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000276550004097271 0.000991261097809614 1.94744252873563 0.733333333333333 16.2 16 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.60560196954349e-06 1.03853254666381e-05 1.94063328912467 0.730769230769231 16.2 16 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.88030930960033e-18 1.46381433841474e-16 1.93702839756592 0.729411764705882 16.2 16 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.88030930960033e-18 1.46381433841474e-16 1.93702839756592 0.729411764705882 16.2 16 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.88030930960033e-18 1.46381433841474e-16 1.93702839756592 0.729411764705882 16.2 16 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 7.60139126271496e-08 6.71849674959216e-07 1.93134796238245 0.727272727272727 16.2 16 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00224817465198719 0.00633495550451045 1.93134796238244 0.727272727272727 16.2 16 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00224817465198719 0.00633495550451045 1.93134796238244 0.727272727272727 16.2 16 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00224817465198719 0.00633495550451045 1.93134796238244 0.727272727272727 16.2 16 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.48484092381927e-25 4.13244052882901e-23 1.92153420241099 0.723577235772358 16.2 16 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.72868780715742e-08 2.65286115650886e-07 1.91793582375479 0.722222222222222 16.2 16 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.64365618490403e-21 1.97995934269391e-19 1.91509864058355 0.721153846153846 16.2 16 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.80660841672954e-19 2.46218353500279e-17 1.91317667779014 0.720430107526882 16.2 16 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 4.32671968609599e-06 2.48262988440104e-05 1.91203448275862 0.72 16.2 16 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 4.32671968609599e-06 2.48262988440104e-05 1.91203448275862 0.72 16.2 16 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 4.32671968609599e-06 2.48262988440104e-05 1.91203448275862 0.72 16.2 16 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 4.32671968609599e-06 2.48262988440104e-05 1.91203448275862 0.72 16.2 16 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 3.30036821486438e-05 0.000158662971951082 1.89685960591133 0.714285714285714 16.2 16 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 3.30036821486438e-05 0.000158662971951082 1.89685960591133 0.714285714285714 16.2 16 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000750710655851143 0.0024168806861452 1.89685960591133 0.714285714285714 16.2 16 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000750710655851143 0.0024168806861452 1.89685960591133 0.714285714285714 16.2 16 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0192105410867242 0.0408008954722514 1.89685960591133 0.714285714285714 16.2 16 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0192105410867242 0.0408008954722514 1.89685960591133 0.714285714285714 16.2 16 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0192105410867242 0.0408008954722514 1.89685960591133 0.714285714285714 16.2 16 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0192105410867242 0.0408008954722514 1.89685960591133 0.714285714285714 16.2 16 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0192105410867242 0.0408008954722514 1.89685960591133 0.714285714285714 16.2 16 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 7.64733283769467e-15 2.47321696091807e-13 1.8916627302787 0.712328767123288 16.2 16 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 2.58916009133226e-08 2.6130317801176e-07 1.88687613430127 0.710526315789474 16.2 16 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.00561998814762e-15 3.66922370034375e-14 1.88245307725884 0.708860759493671 16.2 16 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.00561998814762e-15 3.66922370034375e-14 1.88245307725884 0.708860759493671 16.2 16 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.00561998814762e-15 3.66922370034375e-14 1.88245307725884 0.708860759493671 16.2 16 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 4.52421615621061e-10 5.59822573068495e-09 1.88105244252874 0.708333333333333 16.2 16 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 1.14966518917374e-05 6.22043180301992e-05 1.88105244252874 0.708333333333333 16.2 16 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 9.24166491584045e-09 9.88788659792553e-08 1.87835365853659 0.707317073170732 16.2 16 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000254409404664411 0.000928268161121684 1.87454361054767 0.705882352941177 16.2 16 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.000254409404664411 0.000928268161121684 1.87454361054767 0.705882352941177 16.2 16 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 9.48685175381924e-16 3.66922370034375e-14 1.86875798212005 0.703703703703704 16.2 16 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 9.48685175381924e-16 3.66922370034375e-14 1.86875798212005 0.703703703703704 16.2 16 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 3.76044962304274e-13 8.23249202090741e-12 1.86288600102934 0.701492537313433 16.2 16 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 2.40800442858464e-08 2.44756450133996e-07 1.8589224137931 0.7 16.2 16 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 8.71343974601699e-05 0.000368348993963884 1.8589224137931 0.7 16.2 16 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00607553816665531 0.0149835196033804 1.8589224137931 0.7 16.2 16 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.00607553816665531 0.0149835196033804 1.8589224137931 0.7 16.2 16 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00607553816665531 0.0149835196033804 1.8589224137931 0.7 16.2 16 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00607553816665531 0.0149835196033804 1.8589224137931 0.7 16.2 16 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00607553816665531 0.0149835196033804 1.8589224137931 0.7 16.2 16 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00607553816665531 0.0149835196033804 1.8589224137931 0.7 16.2 16 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00607553816665531 0.0149835196033804 1.8589224137931 0.7 16.2 16 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.00607553816665531 0.0149835196033804 1.8589224137931 0.7 16.2 16 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.51044394157933e-10 2.26248603038672e-09 1.85391184124919 0.69811320754717 16.2 16 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 3.0511270347599e-09 3.39199513317448e-08 1.84737631184408 0.695652173913043 16.2 16 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.51161664959986e-14 1.18889453562604e-12 1.8412183908046 0.693333333333333 16.2 16 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.51161664959986e-14 1.18889453562604e-12 1.8412183908046 0.693333333333333 16.2 16 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.51161664959986e-14 1.18889453562604e-12 1.8412183908046 0.693333333333333 16.2 16 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.51161664959986e-14 1.18889453562604e-12 1.8412183908046 0.693333333333333 16.2 16 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.51161664959986e-14 1.18889453562604e-12 1.8412183908046 0.693333333333333 16.2 16 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.04492345483391e-05 5.71894644703326e-05 1.83849469496021 0.692307692307692 16.2 16 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00198950348918502 0.0056963047587732 1.83849469496021 0.692307692307692 16.2 16 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00198950348918502 0.0056963047587732 1.83849469496021 0.692307692307692 16.2 16 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00198950348918502 0.0056963047587732 1.83849469496021 0.692307692307692 16.2 16 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 3.64764530328529e-06 2.14487572998966e-05 1.83145065398335 0.689655172413793 16.2 16 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000665426341508434 0.00217678548038276 1.82572737068966 0.6875 16.2 16 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000665426341508434 0.00217678548038276 1.82572737068966 0.6875 16.2 16 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 4.49574291003752e-07 3.21479505577055e-06 1.82098522167488 0.685714285714286 16.2 16 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 4.84485576511563e-15 1.60330924506036e-13 1.81205882352941 0.682352941176471 16.2 16 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 7.73869409820746e-05 0.000342753517244648 1.81063871473354 0.681818181818182 16.2 16 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 2.67327578287256e-05 0.00013457034797318 1.80581034482759 0.68 16.2 16 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.1374534705945e-06 7.59904360871347e-06 1.79643762677485 0.676470588235294 16.2 16 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.41114370816551e-07 1.12812218916827e-06 1.79253232758621 0.675 16.2 16 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.33547380308421e-17 1.1459928350996e-15 1.78742539787798 0.673076923076923 16.2 16 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 7.93191126256807e-10 9.64710233045673e-09 1.78649686520376 0.672727272727273 16.2 16 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.64449337829886e-12 3.295935320168e-11 1.78252834199339 0.671232876712329 16.2 16 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 9.97612038727944e-07 6.76000919576126e-06 1.77040229885057 0.666666666666667 16.2 16 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.33037824397313e-05 0.000118857643052823 1.77040229885057 0.666666666666667 16.2 16 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000195395828083222 0.000768089125310567 1.77040229885057 0.666666666666667 16.2 16 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000572756509929415 0.00190428157390084 1.77040229885057 0.666666666666667 16.2 16 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000572756509929415 0.00190428157390084 1.77040229885057 0.666666666666667 16.2 16 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000572756509929415 0.00190428157390084 1.77040229885057 0.666666666666667 16.2 16 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000572756509929415 0.00190428157390084 1.77040229885057 0.666666666666667 16.2 16 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000572756509929415 0.00190428157390084 1.77040229885057 0.666666666666667 16.2 16 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000572756509929415 0.00190428157390084 1.77040229885057 0.666666666666667 16.2 16 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00169903195935888 0.00495434934050756 1.77040229885057 0.666666666666667 16.2 16 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00169903195935888 0.00495434934050756 1.77040229885057 0.666666666666667 16.2 16 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00169903195935888 0.00495434934050756 1.77040229885057 0.666666666666667 16.2 16 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00169903195935888 0.00495434934050756 1.77040229885057 0.666666666666667 16.2 16 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0158729119390856 0.0344316367215225 1.77040229885057 0.666666666666667 16.2 16 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0158729119390856 0.0344316367215225 1.77040229885057 0.666666666666667 16.2 16 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0158729119390856 0.0344316367215225 1.77040229885057 0.666666666666667 16.2 16 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0158729119390856 0.0344316367215225 1.77040229885057 0.666666666666667 16.2 16 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0158729119390856 0.0344316367215225 1.77040229885057 0.666666666666667 16.2 16 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0158729119390856 0.0344316367215225 1.77040229885057 0.666666666666667 16.2 16 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0158729119390856 0.0344316367215225 1.77040229885057 0.666666666666667 16.2 16 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.55680168922706e-08 1.62891823806626e-07 1.77040229885057 0.666666666666667 16.2 16 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 4.39094767993493e-08 3.97982073155886e-07 1.77040229885057 0.666666666666667 16.2 16 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00512614593576253 0.0131670966752508 1.77040229885057 0.666666666666667 16.2 16 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00512614593576253 0.0131670966752508 1.77040229885057 0.666666666666667 16.2 16 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00512614593576253 0.0131670966752508 1.77040229885057 0.666666666666667 16.2 16 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00512614593576253 0.0131670966752508 1.77040229885057 0.666666666666667 16.2 16 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.82682328071202e-08 3.5360841093852e-07 1.75156823184153 0.659574468085106 16.2 16 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.82682328071202e-08 3.5360841093852e-07 1.75156823184153 0.659574468085106 16.2 16 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.07965275088321e-07 9.03732861474594e-07 1.75028409090909 0.659090909090909 16.2 16 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.05187084050355e-07 2.21572051328396e-06 1.74881202691337 0.658536585365854 16.2 16 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.05187084050355e-07 2.21572051328396e-06 1.74881202691337 0.658536585365854 16.2 16 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.4558885648101e-06 1.51944757727164e-05 1.74511083743842 0.657142857142857 16.2 16 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.4558885648101e-06 1.51944757727164e-05 1.74511083743842 0.657142857142857 16.2 16 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.49332860746777e-09 1.72764764912735e-08 1.73987812128419 0.655172413793103 16.2 16 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.49332860746777e-09 1.72764764912735e-08 1.73987812128419 0.655172413793103 16.2 16 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 5.74905240250114e-05 0.000263900050605133 1.73635610079576 0.653846153846154 16.2 16 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 5.74905240250114e-05 0.000263900050605133 1.73635610079576 0.653846153846154 16.2 16 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.59170984225838e-19 1.13250155276684e-17 1.73635610079576 0.653846153846154 16.2 16 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.62566007448102e-07 1.93591413781684e-06 1.72923015236568 0.651162790697674 16.2 16 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 4.60348893854742e-10 5.64721099961464e-09 1.72824986316366 0.650793650793651 16.2 16 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000483216791314059 0.00165292666836516 1.72614224137931 0.65 16.2 16 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000483216791314059 0.00165292666836516 1.72614224137931 0.65 16.2 16 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000483216791314059 0.00165292666836516 1.72614224137931 0.65 16.2 16 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000483216791314059 0.00165292666836516 1.72614224137931 0.65 16.2 16 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 5.96374050267122e-06 3.36762013305601e-05 1.71833164300203 0.647058823529412 16.2 16 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00141895739238914 0.00423307414962212 1.71833164300203 0.647058823529412 16.2 16 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00141895739238914 0.00423307414962212 1.71833164300203 0.647058823529412 16.2 16 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.24066409487081e-07 1.71422849838772e-06 1.71138888888889 0.644444444444444 16.2 16 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 4.98165254531308e-29 7.87654619108945e-27 1.7071736453202 0.642857142857143 16.2 16 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 4.85276614178714e-05 0.000226523780144604 1.7071736453202 0.642857142857143 16.2 16 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.004219330589186 0.0109965337516697 1.7071736453202 0.642857142857143 16.2 16 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 6.90185521869748e-14 1.6933344786563e-12 1.70517695099818 0.642105263157895 16.2 16 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 6.90185521869748e-14 1.6933344786563e-12 1.70517695099818 0.642105263157895 16.2 16 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 6.76997420797442e-08 6.05891402386641e-07 1.69958620689655 0.64 16.2 16 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.87173295326859e-10 3.71497817500109e-09 1.69342828585707 0.63768115942029 16.2 16 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000401911380510231 0.00139492657186844 1.68992946708464 0.636363636363636 16.2 16 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000401911380510231 0.00139492657186844 1.68992946708464 0.636363636363636 16.2 16 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000401911380510231 0.00139492657186844 1.68992946708464 0.636363636363636 16.2 16 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0127734243173245 0.0287149807323109 1.68992946708464 0.636363636363636 16.2 16 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 4.21980681071745e-06 2.46097749657825e-05 1.67722323049002 0.631578947368421 16.2 16 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00116760212356437 0.00354263927895968 1.67722323049002 0.631578947368421 16.2 16 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00116760212356437 0.00354263927895968 1.67722323049002 0.631578947368421 16.2 16 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00116760212356437 0.00354263927895968 1.67722323049002 0.631578947368421 16.2 16 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00116760212356437 0.00354263927895968 1.67722323049002 0.631578947368421 16.2 16 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00116760212356437 0.00354263927895968 1.67722323049002 0.631578947368421 16.2 16 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000115607984719988 0.000470029035018694 1.6720466155811 0.62962962962963 16.2 16 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.3395563877897e-07 1.08751093209861e-06 1.66626098715348 0.627450980392157 16.2 16 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.57406600461398e-09 1.80570356108013e-08 1.6647066392177 0.626865671641791 16.2 16 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.72221333902675e-10 2.55282248066152e-09 1.66417816091954 0.626666666666667 16.2 16 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00342170798910964 0.00923926085104936 1.65975215517241 0.625 16.2 16 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00342170798910964 0.00923926085104936 1.65975215517241 0.625 16.2 16 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0397563212107458 0.0749314504409155 1.65975215517241 0.625 16.2 16 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 5.2245220625438e-11 8.54539643103429e-10 1.65975215517241 0.625 16.2 16 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.01935241590632e-08 3.69002483086109e-07 1.65975215517241 0.625 16.2 16 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.51309900100826e-06 2.08297494934782e-05 1.65975215517241 0.625 16.2 16 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.585770442529e-11 2.89301453810099e-10 1.65584685598377 0.623529411764706 16.2 16 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.31663194356372e-09 1.54840269065386e-08 1.65494127936032 0.623188405797101 16.2 16 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 9.85800213174488e-06 5.41619190481582e-05 1.65078052190121 0.621621621621622 16.2 16 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.92556624887797e-14 1.2743783222097e-12 1.64745769476373 0.62037037037037 16.2 16 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 9.27253677057454e-08 8.04562184422413e-07 1.64164576802508 0.618181818181818 16.2 16 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 2.76921564956803e-05 0.000138266451555625 1.64022565922921 0.617647058823529 16.2 16 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.77776747940843e-08 2.65286115650886e-07 1.63762212643678 0.616666666666667 16.2 16 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.77776747940843e-08 2.65286115650886e-07 1.63762212643678 0.616666666666667 16.2 16 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.77776747940843e-08 2.65286115650886e-07 1.63762212643678 0.616666666666667 16.2 16 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.77776747940843e-08 2.65286115650886e-07 1.63762212643678 0.616666666666667 16.2 16 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.77776747940843e-08 2.65286115650886e-07 1.63762212643678 0.616666666666667 16.2 16 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.77776747940843e-08 2.65286115650886e-07 1.63762212643678 0.616666666666667 16.2 16 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.77776747940843e-08 2.65286115650886e-07 1.63762212643678 0.616666666666667 16.2 16 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 2.56780786045436e-07 1.91238193993105e-06 1.6342175066313 0.615384615384615 16.2 16 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000270148736745036 0.000970761748455015 1.6342175066313 0.615384615384615 16.2 16 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000270148736745036 0.000970761748455015 1.6342175066313 0.615384615384615 16.2 16 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0101447738502866 0.0233592446423265 1.6342175066313 0.615384615384615 16.2 16 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0101447738502866 0.0233592446423265 1.6342175066313 0.615384615384615 16.2 16 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0101447738502866 0.0233592446423265 1.6342175066313 0.615384615384615 16.2 16 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0101447738502866 0.0233592446423265 1.6342175066313 0.615384615384615 16.2 16 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0101447738502866 0.0233592446423265 1.6342175066313 0.615384615384615 16.2 16 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0101447738502866 0.0233592446423265 1.6342175066313 0.615384615384615 16.2 16 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0101447738502866 0.0233592446423265 1.6342175066313 0.615384615384615 16.2 16 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0101447738502866 0.0233592446423265 1.6342175066313 0.615384615384615 16.2 16 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 7.78791091866081e-05 0.000342753517244648 1.62762791991101 0.612903225806452 16.2 16 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 7.78791091866081e-05 0.000342753517244648 1.62762791991101 0.612903225806452 16.2 16 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.79949029768765e-19 1.89698794933787e-17 1.62655711206897 0.6125 16.2 16 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00274870163625443 0.00756460680330493 1.62286877394636 0.611111111111111 16.2 16 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00274870163625443 0.00756460680330493 1.62286877394636 0.611111111111111 16.2 16 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00274870163625443 0.00756460680330493 1.62286877394636 0.611111111111111 16.2 16 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.96718123951686e-06 1.25529098826569e-05 1.61645427286357 0.608695652173913 16.2 16 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000768752331522691 0.00246937825678734 1.61645427286357 0.608695652173913 16.2 16 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 5.83783318891092e-07 4.05231055015621e-06 1.61419033130494 0.607843137254902 16.2 16 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 5.83783318891092e-07 4.05231055015621e-06 1.61419033130494 0.607843137254902 16.2 16 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.78075687550113e-13 1.01537567669226e-11 1.61321704801805 0.607476635514019 16.2 16 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000219277575277803 0.000854882163343327 1.61233066502463 0.607142857142857 16.2 16 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.295088930528e-12 8.25933992992073e-11 1.6094566353187 0.606060606060606 16.2 16 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 4.295088930528e-12 8.25933992992073e-11 1.6094566353187 0.606060606060606 16.2 16 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 3.24481829712433e-13 7.32916894731416e-12 1.60293181112147 0.603603603603604 16.2 16 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.000618099911946668 0.00204547947604677 1.59336206896552 0.6 16.2 16 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000177142184734464 0.000702154119434936 1.59336206896552 0.6 16.2 16 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.000177142184734464 0.000702154119434936 1.59336206896552 0.6 16.2 16 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00219418012193983 0.00625715092889855 1.59336206896552 0.6 16.2 16 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0079997785339267 0.018816008022773 1.59336206896552 0.6 16.2 16 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0079997785339267 0.018816008022773 1.59336206896552 0.6 16.2 16 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0079997785339267 0.018816008022773 1.59336206896552 0.6 16.2 16 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0079997785339267 0.018816008022773 1.59336206896552 0.6 16.2 16 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0079997785339267 0.018816008022773 1.59336206896552 0.6 16.2 16 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.030568972597731 0.0597522637452901 1.59336206896552 0.6 16.2 16 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.030568972597731 0.0597522637452901 1.59336206896552 0.6 16.2 16 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.030568972597731 0.0597522637452901 1.59336206896552 0.6 16.2 16 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.030568972597731 0.0597522637452901 1.59336206896552 0.6 16.2 16 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.030568972597731 0.0597522637452901 1.59336206896552 0.6 16.2 16 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.030568972597731 0.0597522637452901 1.59336206896552 0.6 16.2 16 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.030568972597731 0.0597522637452901 1.59336206896552 0.6 16.2 16 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.030568972597731 0.0597522637452901 1.59336206896552 0.6 16.2 16 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 5.13802332583154e-05 0.000238934875577068 1.59336206896552 0.6 16.2 16 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.65185125874972e-14 5.22352075822411e-13 1.58918001629107 0.598425196850394 16.2 16 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.45680321327573e-14 1.18889453562604e-12 1.58479560622914 0.596774193548387 16.2 16 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.45680321327573e-14 1.18889453562604e-12 1.58479560622914 0.596774193548387 16.2 16 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.45680321327573e-14 1.18889453562604e-12 1.58479560622914 0.596774193548387 16.2 16 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 9.4892802783061e-08 8.18378535516944e-07 1.58479560622914 0.596774193548387 16.2 16 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.07324918501547e-44 2.18176227182431e-42 1.5833879715072 0.596244131455399 16.2 16 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.06650134356802e-06 7.1925659331625e-06 1.58314820954907 0.596153846153846 16.2 16 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.314752872542e-08 2.36970743714192e-07 1.57796726636682 0.594202898550725 16.2 16 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.314752872542e-08 2.36970743714192e-07 1.57796726636682 0.594202898550725 16.2 16 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00014256369978156 0.000574697294020282 1.57676454741379 0.59375 16.2 16 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.58030451487535e-07 1.91238193993105e-06 1.57535797779077 0.593220338983051 16.2 16 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.58030451487535e-07 1.91238193993105e-06 1.57535797779077 0.593220338983051 16.2 16 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 8.65098704270135e-07 5.89012179988709e-06 1.57369093231162 0.592592592592593 16.2 16 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000494935285145104 0.00167290477615554 1.57369093231162 0.592592592592593 16.2 16 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000494935285145104 0.00167290477615554 1.57369093231162 0.592592592592593 16.2 16 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000494935285145104 0.00167290477615554 1.57369093231162 0.592592592592593 16.2 16 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000494935285145104 0.00167290477615554 1.57369093231162 0.592592592592593 16.2 16 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000494935285145104 0.00167290477615554 1.57369093231162 0.592592592592593 16.2 16 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 5.65951645577005e-09 6.14770375309984e-08 1.57239677858439 0.592105263157895 16.2 16 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.82875678790998e-11 6.40978930493636e-10 1.57168367346939 0.591836734693878 16.2 16 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.88147353651012e-08 1.95426046894446e-07 1.57092034968431 0.591549295774648 16.2 16 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.86219330168804e-12 5.65680703930844e-11 1.56922021943574 0.590909090909091 16.2 16 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00174394676641984 0.00505424897885017 1.56922021943574 0.590909090909091 16.2 16 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00174394676641984 0.00505424897885017 1.56922021943574 0.590909090909091 16.2 16 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00174394676641984 0.00505424897885017 1.56922021943574 0.590909090909091 16.2 16 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 2.09201067215635e-07 1.63641933866786e-06 1.56724137931034 0.590163934426229 16.2 16 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.11574487820078e-11 5.27822019247584e-10 1.56680603448276 0.59 16.2 16 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.02908691935453e-10 1.59172900678423e-09 1.56540834845735 0.589473684210526 16.2 16 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000114386424474698 0.00046639507744268 1.56211967545639 0.588235294117647 16.2 16 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0062827802701389 0.0153088978157665 1.56211967545639 0.588235294117647 16.2 16 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0062827802701389 0.0153088978157665 1.56211967545639 0.588235294117647 16.2 16 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0062827802701389 0.0153088978157665 1.56211967545639 0.588235294117647 16.2 16 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0062827802701389 0.0153088978157665 1.56211967545639 0.588235294117647 16.2 16 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0062827802701389 0.0153088978157665 1.56211967545639 0.588235294117647 16.2 16 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0062827802701389 0.0153088978157665 1.56211967545639 0.588235294117647 16.2 16 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 6.77817154019754e-23 6.43022540113407e-21 1.56001816916654 0.587443946188341 16.2 16 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 7.92758354234909e-06 4.40662163311045e-05 1.55872376311844 0.58695652173913 16.2 16 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 4.10977724103659e-08 3.74885449615068e-07 1.55542487684729 0.585714285714286 16.2 16 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.35317527982291e-51 6.41856141062667e-49 1.55499213321096 0.585551330798479 16.2 16 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.68573287592293e-05 0.00013457034797318 1.55449957947855 0.585365853658537 16.2 16 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.68573287592293e-05 0.00013457034797318 1.55449957947855 0.585365853658537 16.2 16 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.68573287592293e-05 0.00013457034797318 1.55449957947855 0.585365853658537 16.2 16 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.68573287592293e-05 0.00013457034797318 1.55449957947855 0.585365853658537 16.2 16 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 7.58683543566102e-14 1.82984183473655e-12 1.54910201149425 0.583333333333333 16.2 16 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 9.15511964483962e-05 0.000384298975062147 1.54910201149425 0.583333333333333 16.2 16 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00138187264375069 0.00416611180520599 1.54910201149425 0.583333333333333 16.2 16 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00138187264375069 0.00416611180520599 1.54910201149425 0.583333333333333 16.2 16 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0234796140515113 0.047191371179803 1.54910201149425 0.583333333333333 16.2 16 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0234796140515113 0.047191371179803 1.54910201149425 0.583333333333333 16.2 16 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0234796140515113 0.047191371179803 1.54910201149425 0.583333333333333 16.2 16 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0234796140515113 0.047191371179803 1.54910201149425 0.583333333333333 16.2 16 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0234796140515113 0.047191371179803 1.54910201149425 0.583333333333333 16.2 16 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 8.8828687963412e-26 1.14912020883578e-23 1.54655833003039 0.582375478927203 16.2 16 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.10360976407673e-07 9.13044589698365e-07 1.54579902213073 0.582089552238806 16.2 16 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.10360976407673e-07 9.13044589698365e-07 1.54579902213073 0.582089552238806 16.2 16 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 6.85495856333895e-22 5.41922557535074e-20 1.54507836990596 0.581818181818182 16.2 16 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.97454224048118e-09 2.22997905413073e-08 1.54395549318364 0.581395348837209 16.2 16 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000314583366262261 0.00111356251291343 1.54196329254727 0.580645161290323 16.2 16 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.14304570917443e-28 3.04955404415521e-26 1.54079380957985 0.580204778156997 16.2 16 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.1842094710846e-10 1.81196782511116e-09 1.54025 0.58 16.2 16 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 5.63512661989066e-17 2.67292839336813e-15 1.53993572740257 0.579881656804734 16.2 16 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.90682216270893e-11 5.06686553645134e-10 1.53876087657106 0.579439252336449 16.2 16 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.5662068236557e-46 4.45742462012412e-44 1.53830687552565 0.579268292682927 16.2 16 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.31957500197738e-13 3.07828725871118e-12 1.53745462794918 0.578947368421053 16.2 16 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00492271346620327 0.0127828855153417 1.53745462794918 0.578947368421053 16.2 16 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 5.26169943898243e-09 5.75953715513231e-08 1.53577066888243 0.578313253012048 16.2 16 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.95537909004824e-07 2.16778579646322e-06 1.53527074353448 0.578125 16.2 16 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.28512287377774e-09 1.52394154115477e-08 1.53434865900383 0.577777777777778 16.2 16 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00109257878722162 0.00336523726020859 1.53207891246684 0.576923076923077 16.2 16 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00109257878722162 0.00336523726020859 1.53207891246684 0.576923076923077 16.2 16 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.94463186405028e-16 1.65094445368928e-14 1.53145229532473 0.576687116564417 16.2 16 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 9.73532806732847e-17 4.46882962574465e-15 1.53087728194726 0.576470588235294 16.2 16 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000250013997429165 0.000916932779231189 1.52898380355277 0.575757575757576 16.2 16 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000250013997429165 0.000916932779231189 1.52898380355277 0.575757575757576 16.2 16 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.4094321217335e-09 3.76094721645486e-08 1.52620887831946 0.574712643678161 16.2 16 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.37763976416105e-05 7.34225237603437e-05 1.52555942773294 0.574468085106383 16.2 16 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.74169467776379e-15 9.28912268204255e-14 1.52232044805623 0.573248407643312 16.2 16 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.20815873220123e-15 7.66392652663988e-14 1.51987367165474 0.572327044025157 16.2 16 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 4.64301249003441e-05 0.000218775058719171 1.51748768472906 0.571428571428571 16.2 16 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000198394679429876 0.000777729005037777 1.51748768472906 0.571428571428571 16.2 16 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000862478898301506 0.00268557433759966 1.51748768472906 0.571428571428571 16.2 16 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0180453648650873 0.0386725213900891 1.51748768472906 0.571428571428571 16.2 16 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0180453648650873 0.0386725213900891 1.51748768472906 0.571428571428571 16.2 16 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0180453648650873 0.0386725213900891 1.51748768472906 0.571428571428571 16.2 16 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 4.32392544853199e-10 5.39732097654476e-09 1.51369396551724 0.57 16.2 16 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.96953252634867e-08 2.79844025496302e-07 1.51268550851157 0.569620253164557 16.2 16 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.05307818666351e-07 3.577378238618e-06 1.51165119363395 0.569230769230769 16.2 16 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.09837989855547e-06 1.33303330162698e-05 1.51094678953627 0.568965517241379 16.2 16 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.79845906031816e-09 6.25091457790359e-08 1.50886559561129 0.568181818181818 16.2 16 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 9.78286957271163e-08 8.33594215686745e-07 1.50723438956198 0.567567567567568 16.2 16 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 9.78286957271163e-08 8.33594215686745e-07 1.50723438956198 0.567567567567568 16.2 16 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00015724064309379 0.000630291366542152 1.50723438956198 0.567567567567568 16.2 16 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00015724064309379 0.000630291366542152 1.50723438956198 0.567567567567568 16.2 16 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000680049602061809 0.0022195196874632 1.50484195402299 0.566666666666667 16.2 16 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.18759054303947e-14 9.860742049446e-13 1.50251247731397 0.565789473684211 16.2 16 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 7.82167069029862e-08 6.87051690882404e-07 1.50251247731397 0.565789473684211 16.2 16 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.68897685197668e-46 6.37735676727135e-44 1.5018581299238 0.565543071161049 16.2 16 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.93395269241061e-05 0.000145979534311199 1.50099325337331 0.565217391304348 16.2 16 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00301169953178614 0.00817871838498413 1.50099325337331 0.565217391304348 16.2 16 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00301169953178614 0.00817871838498413 1.50099325337331 0.565217391304348 16.2 16 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00301169953178614 0.00817871838498413 1.50099325337331 0.565217391304348 16.2 16 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.33526277964235e-06 8.79666173810679e-06 1.49913097886541 0.564516129032258 16.2 16 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00012450060537436 0.000503307845021918 1.49803271441202 0.564102564102564 16.2 16 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.42995796086047e-10 2.16471295564303e-09 1.49679467084639 0.563636363636364 16.2 16 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 5.55772082199502e-06 3.15085128673264e-05 1.49679467084639 0.563636363636364 16.2 16 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 5.55772082199502e-06 3.15085128673264e-05 1.49679467084639 0.563636363636364 16.2 16 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.57350466855558e-07 1.91238193993105e-06 1.49611461874696 0.563380281690141 16.2 16 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.58832477805932e-16 7.06308174743254e-15 1.49468390804598 0.562841530054645 16.2 16 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0138858692344058 0.0306625035619353 1.49377693965517 0.5625 16.2 16 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0138858692344058 0.0306625035619353 1.49377693965517 0.5625 16.2 16 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0138858692344058 0.0306625035619353 1.49377693965517 0.5625 16.2 16 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0138858692344058 0.0306625035619353 1.49377693965517 0.5625 16.2 16 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0138858692344058 0.0306625035619353 1.49377693965517 0.5625 16.2 16 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0138858692344058 0.0306625035619353 1.49377693965517 0.5625 16.2 16 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 8.75020367576327e-13 1.80457098994364e-11 1.49019474075912 0.561151079136691 16.2 16 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.45608350804516e-83 2.07200683194826e-80 1.48862655759207 0.560560560560561 16.2 16 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00235394702968309 0.00658087745233601 1.48713793103448 0.56 16.2 16 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00235394702968309 0.00658087745233601 1.48713793103448 0.56 16.2 16 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00235394702968309 0.00658087745233601 1.48713793103448 0.56 16.2 16 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00235394702968309 0.00658087745233601 1.48713793103448 0.56 16.2 16 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 3.51250454527316e-06 2.08297494934782e-05 1.48533752191701 0.559322033898305 16.2 16 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.01058164392921e-23 3.06004119950805e-21 1.48401369168357 0.558823529411765 16.2 16 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000421808923171485 0.00145687887784714 1.48401369168357 0.558823529411765 16.2 16 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000421808923171485 0.00145687887784714 1.48401369168357 0.558823529411765 16.2 16 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 2.78984458939414e-06 1.6913048239517e-05 1.4801724137931 0.557377049180328 16.2 16 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.78984458939414e-06 1.6913048239517e-05 1.4801724137931 0.557377049180328 16.2 16 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 5.36149387625139e-07 3.75832797335257e-06 1.47955049261084 0.557142857142857 16.2 16 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.48057032400197e-16 1.50086411244085e-14 1.47691314770422 0.556149732620321 16.2 16 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.21471670988425e-06 1.38834443972039e-05 1.47533524904215 0.555555555555556 16.2 16 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 2.21471670988425e-06 1.38834443972039e-05 1.47533524904215 0.555555555555556 16.2 16 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.16060715951621e-05 6.25584843936197e-05 1.47533524904215 0.555555555555556 16.2 16 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000331949033156725 0.0011721178019405 1.47533524904215 0.555555555555556 16.2 16 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00183963316481725 0.00532072762913608 1.47533524904215 0.555555555555556 16.2 16 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.069610582800321 0.119057523226991 1.47533524904215 0.555555555555556 16.2 16 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.069610582800321 0.119057523226991 1.47533524904215 0.555555555555556 16.2 16 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.069610582800321 0.119057523226991 1.47533524904215 0.555555555555556 16.2 16 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.069610582800321 0.119057523226991 1.47533524904215 0.555555555555556 16.2 16 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.069610582800321 0.119057523226991 1.47533524904215 0.555555555555556 16.2 16 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.069610582800321 0.119057523226991 1.47533524904215 0.555555555555556 16.2 16 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 6.15393719893869e-05 0.000277121918800308 1.47533524904215 0.555555555555556 16.2 16 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.45299265969032e-13 3.33485250764407e-12 1.47343159065628 0.554838709677419 16.2 16 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 7.66835413126859e-11 1.21245199208836e-09 1.470458107723 0.553719008264463 16.2 16 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 7.66835413126859e-11 1.21245199208836e-09 1.470458107723 0.553719008264463 16.2 16 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 3.83804483213171e-05 0.000181446438409416 1.46329169598874 0.551020408163265 16.2 16 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 3.83804483213171e-05 0.000181446438409416 1.46329169598874 0.551020408163265 16.2 16 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.10513551908338e-06 7.41796152667758e-06 1.46250624687656 0.550724637681159 16.2 16 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00825758755363635 0.01935839718093 1.46058189655172 0.55 16.2 16 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00825758755363635 0.01935839718093 1.46058189655172 0.55 16.2 16 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.84294562253588e-12 9.18868216115807e-11 1.46058189655172 0.55 16.2 16 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.34499670563665e-07 1.08751093209861e-06 1.45734335576114 0.548780487804878 16.2 16 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00112383003124697 0.00345401756903767 1.45629866518354 0.548387096774194 16.2 16 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.06689953870497e-07 8.9834203761963e-07 1.45425903119869 0.547619047619048 16.2 16 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.06689953870497e-07 8.9834203761963e-07 1.45425903119869 0.547619047619048 16.2 16 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.60362429316902e-06 2.12778314073839e-05 1.45228313577586 0.546875 16.2 16 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00638133932699908 0.0155224715595208 1.44851097178683 0.545454545454545 16.2 16 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0519236305342187 0.0929400330191109 1.44851097178683 0.545454545454545 16.2 16 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0519236305342187 0.0929400330191109 1.44851097178683 0.545454545454545 16.2 16 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0519236305342187 0.0929400330191109 1.44851097178683 0.545454545454545 16.2 16 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0519236305342187 0.0929400330191109 1.44851097178683 0.545454545454545 16.2 16 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.86756368955456e-18 1.06301725209446e-16 1.44747484090573 0.545064377682403 16.2 16 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 7.7594029248982e-13 1.62376917090149e-11 1.4469634173298 0.544871794871795 16.2 16 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.0076681962495e-10 2.94526994150829e-09 1.44654821979254 0.544715447154472 16.2 16 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 9.98725208766262e-05 0.000409563680713081 1.44326274362819 0.543478260869565 16.2 16 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.57543159229688e-11 2.89301453810099e-10 1.44161330049261 0.542857142857143 16.2 16 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.00450462926875e-10 1.5707803158785e-09 1.4410251269714 0.542635658914729 16.2 16 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 2.16027523935593e-07 1.66166035978567e-06 1.43978500207727 0.542168674698795 16.2 16 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.40743141396469e-06 9.22937742890208e-06 1.43845186781609 0.541666666666667 16.2 16 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.00493785858128259 0.0127988574884611 1.43845186781609 0.541666666666667 16.2 16 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 4.03784636073262e-10 5.08482776223231e-09 1.43663793103448 0.540983606557377 16.2 16 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.35270158103622e-07 1.08751093209861e-06 1.43463634562029 0.540229885057471 16.2 16 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.35270158103622e-07 1.08751093209861e-06 1.43463634562029 0.540229885057471 16.2 16 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.98517665636452e-11 3.57583086329963e-10 1.42994031830239 0.538461538461538 16.2 16 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 4.85521805650769e-05 0.000226523780144604 1.42994031830239 0.538461538461538 16.2 16 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 4.85521805650769e-05 0.000226523780144604 1.42994031830239 0.538461538461538 16.2 16 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00382554331255478 0.0102326092739952 1.42994031830239 0.538461538461538 16.2 16 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00382554331255478 0.0102326092739952 1.42994031830239 0.538461538461538 16.2 16 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0390369276196068 0.0744632010760061 1.42994031830239 0.538461538461538 16.2 16 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0390369276196068 0.0744632010760061 1.42994031830239 0.538461538461538 16.2 16 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0390369276196068 0.0744632010760061 1.42994031830239 0.538461538461538 16.2 16 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0390369276196068 0.0744632010760061 1.42994031830239 0.538461538461538 16.2 16 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0390369276196068 0.0744632010760061 1.42994031830239 0.538461538461538 16.2 16 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 3.00243854016149e-05 0.000148866552008704 1.4226447044335 0.535714285714286 16.2 16 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00296711885695084 0.00810405016015555 1.4226447044335 0.535714285714286 16.2 16 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00296711885695084 0.00810405016015555 1.4226447044335 0.535714285714286 16.2 16 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.09293728051215e-14 1.54825888395871e-12 1.42212643678161 0.53551912568306 16.2 16 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.00590662650014e-10 5.08482776223231e-09 1.42189790931306 0.535433070866142 16.2 16 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000257729764753962 0.000937978146406362 1.42043905372895 0.534883720930233 16.2 16 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 4.64239529072615e-19 2.87222978204492e-17 1.41972645888594 0.534615384615385 16.2 16 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.85720716753516e-05 9.75205092030453e-05 1.41632183908046 0.533333333333333 16.2 16 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0295260349578422 0.0583549274236243 1.41632183908046 0.533333333333333 16.2 16 2 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.0295260349578422 0.0583549274236243 1.41632183908046 0.533333333333333 16.2 16 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0295260349578422 0.0583549274236243 1.41632183908046 0.533333333333333 16.2 16 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 6.09672014408488e-12 1.141530626978e-10 1.41183980794413 0.531645569620253 16.2 16 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 8.6022830948218e-07 5.88511963650549e-06 1.40976479352916 0.530864197530864 16.2 16 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 9.71278137011261e-05 0.000405316360400887 1.40590770791075 0.529411764705882 16.2 16 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00139256757200314 0.00417183927360097 1.40590770791075 0.529411764705882 16.2 16 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00139256757200314 0.00417183927360097 1.40590770791075 0.529411764705882 16.2 16 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00139256757200314 0.00417183927360097 1.40590770791075 0.529411764705882 16.2 16 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.022439344319206 0.045421318586387 1.40590770791075 0.529411764705882 16.2 16 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.022439344319206 0.045421318586387 1.40590770791075 0.529411764705882 16.2 16 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.022439344319206 0.045421318586387 1.40590770791075 0.529411764705882 16.2 16 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.022439344319206 0.045421318586387 1.40590770791075 0.529411764705882 16.2 16 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.022439344319206 0.045421318586387 1.40590770791075 0.529411764705882 16.2 16 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 7.61530985353287e-05 0.000340773142187964 1.40296031229668 0.528301886792453 16.2 16 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.40463847202434e-06 2.51718897417295e-05 1.40156848659004 0.527777777777778 16.2 16 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.00108406167789115 0.00335352123399807 1.40156848659004 0.527777777777778 16.2 16 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 5.97232385079449e-05 0.000270628462693713 1.40022727272727 0.527272727272727 16.2 16 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 5.97232385079449e-05 0.000270628462693713 1.40022727272727 0.527272727272727 16.2 16 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.97232385079449e-05 0.000270628462693713 1.40022727272727 0.527272727272727 16.2 16 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 5.97232385079449e-05 0.000270628462693713 1.40022727272727 0.527272727272727 16.2 16 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.72838763635827e-06 1.67348948557664e-05 1.39768602540835 0.526315789473684 16.2 16 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000844533607629792 0.00263546342907279 1.39768602540835 0.526315789473684 16.2 16 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.13608533779295e-13 2.69441572613227e-12 1.39695806393678 0.526041666666667 16.2 16 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.1476410530879e-06 1.35826365268626e-05 1.39589412024757 0.525641025641026 16.2 16 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.14409692050441e-12 2.32578559696825e-11 1.39531706604325 0.525423728813559 16.2 16 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000658386658723255 0.00216370488536534 1.39419181034483 0.525 16.2 16 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000658386658723255 0.00216370488536534 1.39419181034483 0.525 16.2 16 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.33102223763197e-06 8.79666173810679e-06 1.39257253994954 0.524390243902439 16.2 16 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.013103896139285 0.0292729108417621 1.39103037766831 0.523809523809524 16.2 16 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.013103896139285 0.0292729108417621 1.39103037766831 0.523809523809524 16.2 16 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 8.25189564511353e-07 5.67267995313844e-06 1.38955994386528 0.523255813953488 16.2 16 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000400892094838507 0.00139492657186844 1.38815634796238 0.522727272727273 16.2 16 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000400892094838507 0.00139492657186844 1.38815634796238 0.522727272727273 16.2 16 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000400892094838507 0.00139492657186844 1.38815634796238 0.522727272727273 16.2 16 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.3963559426819e-05 7.41423323297144e-05 1.38725553268142 0.522388059701492 16.2 16 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 5.11752825834508e-07 3.60507064931933e-06 1.38681513409962 0.522222222222222 16.2 16 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000313092190438984 0.00111104784786702 1.38553223388306 0.521739130434783 16.2 16 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0100573100126859 0.0233592446423265 1.38553223388306 0.521739130434783 16.2 16 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0100573100126859 0.0233592446423265 1.38553223388306 0.521739130434783 16.2 16 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 9.44664528401322e-09 1.00317733127991e-07 1.38359171254709 0.521008403361345 16.2 16 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.77033798465596e-06 3.77811409888841e-05 1.38236891828059 0.520547945205479 16.2 16 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000191259583689025 0.000753912430995797 1.38091379310345 0.52 16.2 16 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000191259583689025 0.000753912430995797 1.38091379310345 0.52 16.2 16 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00773709609551539 0.0183498129065307 1.38091379310345 0.52 16.2 16 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.5849608176412e-06 1.59238062489326e-05 1.37697956577267 0.518518518518518 16.2 16 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00596421577934906 0.0149420405880523 1.37697956577267 0.518518518518518 16.2 16 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00596421577934906 0.0149420405880523 1.37697956577267 0.518518518518518 16.2 16 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00596421577934906 0.0149420405880523 1.37697956577267 0.518518518518518 16.2 16 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00596421577934906 0.0149420405880523 1.37697956577267 0.518518518518518 16.2 16 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 8.82046464881112e-10 1.06368823688629e-08 1.37556437608534 0.517985611510791 16.2 16 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.59868373264174e-06 1.03853254666381e-05 1.37466531440162 0.517647058823529 16.2 16 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.59868373264174e-06 1.03853254666381e-05 1.37466531440162 0.517647058823529 16.2 16 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 5.62019517605682e-05 0.000259660316088599 1.3720617816092 0.516666666666667 16.2 16 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 3.45209058359594e-05 0.00016429180269087 1.36929552801724 0.515625 16.2 16 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00275898168019343 0.00756460680330493 1.3680381400209 0.515151515151515 16.2 16 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00275898168019343 0.00756460680330493 1.3680381400209 0.515151515151515 16.2 16 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00275898168019343 0.00756460680330493 1.3680381400209 0.515151515151515 16.2 16 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.31058860981898e-53 1.64398379588621e-50 1.36685471602434 0.514705882352941 16.2 16 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.30688881638566e-05 6.99136385607818e-05 1.36468510536398 0.513888888888889 16.2 16 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.30688881638566e-05 6.99136385607818e-05 1.36468510536398 0.513888888888889 16.2 16 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 9.03368874070526e-08 7.88646569203901e-07 1.36434672571971 0.513761467889908 16.2 16 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0010040518729459 0.00311957601572493 1.36018713204373 0.51219512195122 16.2 16 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.40901095639738e-06 1.50351868024275e-05 1.3586808340016 0.511627906976744 16.2 16 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000781653172141568 0.00250516320711138 1.3586808340016 0.511627906976744 16.2 16 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.3033981620488e-13 7.34489935093038e-12 1.35309318555008 0.509523809523809 16.2 16 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000107938968782597 0.000441371128096655 1.35030683810637 0.508474576271186 16.2 16 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 5.17839801747527e-05 0.000240028025370271 1.34822944297082 0.507692307692308 16.2 16 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.48201184710571e-10 4.46387644903733e-09 1.34439924568966 0.50625 16.2 16 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 2.8181654644474e-06 1.69925824402909e-05 1.34272084463386 0.50561797752809 16.2 16 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.54533578705151e-07 1.91238193993105e-06 1.33998339133186 0.504587155963303 16.2 16 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 9.65203860985205e-19 5.72285455909145e-17 1.3359477469854 0.503067484662577 16.2 16 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 6.99181503356046e-08 6.21834549547284e-07 1.32780172413793 0.5 16.2 16 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000334652815257316 0.00117873999037416 1.32780172413793 0.5 16.2 16 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 5.49850334933226e-11 8.8913298478407e-10 1.32780172413793 0.5 16.2 16 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.3147666617657e-07 1.76145078058427e-06 1.32780172413793 0.5 16.2 16 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.25842635317464e-06 1.95643067534494e-05 1.32780172413793 0.5 16.2 16 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 5.99072141591845e-05 0.000270628462693713 1.32780172413793 0.5 16.2 16 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000204240463341189 0.000798445547622284 1.32780172413793 0.5 16.2 16 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00533413538430553 0.0136765309042644 1.32780172413793 0.5 16.2 16 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0151767614440892 0.0332948788590451 1.32780172413793 0.5 16.2 16 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0151767614440892 0.0332948788590451 1.32780172413793 0.5 16.2 16 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0198264529515708 0.041859113575794 1.32780172413793 0.5 16.2 16 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0198264529515708 0.041859113575794 1.32780172413793 0.5 16.2 16 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0341783100759175 0.0662612196703415 1.32780172413793 0.5 16.2 16 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0341783100759175 0.0662612196703415 1.32780172413793 0.5 16.2 16 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0341783100759175 0.0662612196703415 1.32780172413793 0.5 16.2 16 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0451662006812787 0.0830381183067954 1.32780172413793 0.5 16.2 16 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0451662006812787 0.0830381183067954 1.32780172413793 0.5 16.2 16 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0451662006812787 0.0830381183067954 1.32780172413793 0.5 16.2 16 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0451662006812787 0.0830381183067954 1.32780172413793 0.5 16.2 16 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0451662006812787 0.0830381183067954 1.32780172413793 0.5 16.2 16 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0451662006812787 0.0830381183067954 1.32780172413793 0.5 16.2 16 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0451662006812787 0.0830381183067954 1.32780172413793 0.5 16.2 16 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0600284903741266 0.106376764386528 1.32780172413793 0.5 16.2 16 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0600284903741266 0.106376764386528 1.32780172413793 0.5 16.2 16 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0600284903741266 0.106376764386528 1.32780172413793 0.5 16.2 16 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0803676470169261 0.132518147978083 1.32780172413793 0.5 16.2 16 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0803676470169261 0.132518147978083 1.32780172413793 0.5 16.2 16 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0803676470169261 0.132518147978083 1.32780172413793 0.5 16.2 16 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0803676470169261 0.132518147978083 1.32780172413793 0.5 16.2 16 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0803676470169261 0.132518147978083 1.32780172413793 0.5 16.2 16 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0803676470169261 0.132518147978083 1.32780172413793 0.5 16.2 16 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0803676470169261 0.132518147978083 1.32780172413793 0.5 16.2 16 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.108652193002911 0.174308986068932 1.32780172413793 0.5 16.2 16 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.108652193002911 0.174308986068932 1.32780172413793 0.5 16.2 16 2 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.108652193002911 0.174308986068932 1.32780172413793 0.5 16.2 16 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.108652193002911 0.174308986068932 1.32780172413793 0.5 16.2 16 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.108652193002911 0.174308986068932 1.32780172413793 0.5 16.2 16 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.108652193002911 0.174308986068932 1.32780172413793 0.5 16.2 16 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.44964708849797e-15 5.15711951733154e-14 1.32300821610855 0.498194945848375 16.2 16 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.83963722212135e-09 3.18173524966825e-08 1.31923526140156 0.496774193548387 16.2 16 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.64299037719829e-07 1.30613145628668e-06 1.31682815616985 0.495867768595041 16.2 16 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.58617670509499e-09 1.80570356108013e-08 1.31160902018503 0.49390243902439 16.2 16 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.02501855023513e-05 0.000104028931299083 1.31140911025968 0.493827160493827 16.2 16 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000232459812019173 0.000903798668041757 1.30603448275862 0.491803278688525 16.2 16 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 7.86008702144761e-07 5.42956496675725e-06 1.30409097906404 0.491071428571429 16.2 16 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 8.22877128009998e-23 7.31846345723892e-21 1.30398465285295 0.491031390134529 16.2 16 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.32027926830931e-06 1.98519218437149e-05 1.30124568965517 0.49 16.2 16 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00217495331903702 0.00621477625098329 1.29692261427426 0.488372093023256 16.2 16 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00360478880685638 0.00971517892453906 1.29375552608311 0.487179487179487 16.2 16 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0046482172784269 0.0120921630479003 1.29191519105312 0.486486486486487 16.2 16 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 4.55383278525228e-11 7.53500471327209e-10 1.2898645320197 0.485714285714286 16.2 16 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0060009459805769 0.0149835196033804 1.2898645320197 0.485714285714286 16.2 16 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 9.56522494931003e-37 1.70141438785852e-34 1.28529846792353 0.483994878361076 16.2 16 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0130265277154415 0.0291917306127138 1.28201545778835 0.482758620689655 16.2 16 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0130265277154415 0.0291917306127138 1.28201545778835 0.482758620689655 16.2 16 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.25668190423614e-05 0.000157627835024763 1.28093813387424 0.482352941176471 16.2 16 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.25668190423614e-05 0.000157627835024763 1.28093813387424 0.482352941176471 16.2 16 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.25668190423614e-05 0.000157627835024763 1.28093813387424 0.482352941176471 16.2 16 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.25668190423614e-05 0.000157627835024763 1.28093813387424 0.482352941176471 16.2 16 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.25668190423614e-05 0.000157627835024763 1.28093813387424 0.482352941176471 16.2 16 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.016927051041951 0.0365511284259428 1.27862388250319 0.481481481481481 16.2 16 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.016927051041951 0.0365511284259428 1.27862388250319 0.481481481481481 16.2 16 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.34632634434134e-07 2.40496080201905e-06 1.27712226901816 0.480916030534351 16.2 16 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.34632634434134e-07 2.40496080201905e-06 1.27712226901816 0.480916030534351 16.2 16 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00114371226087675 0.00350754859316297 1.2767324270557 0.480769230769231 16.2 16 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0220441448427728 0.0450054779214715 1.27468965517241 0.48 16.2 16 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0220441448427728 0.0450054779214715 1.27468965517241 0.48 16.2 16 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0220441448427728 0.0450054779214715 1.27468965517241 0.48 16.2 16 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0287815006455486 0.0571214440984876 1.2700712143928 0.478260869565217 16.2 16 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00398424198384706 0.0105973389589054 1.26457307060755 0.476190476190476 16.2 16 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00398424198384706 0.0105973389589054 1.26457307060755 0.476190476190476 16.2 16 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00398424198384706 0.0105973389589054 1.26457307060755 0.476190476190476 16.2 16 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0376901791605284 0.0724771958722053 1.26457307060755 0.476190476190476 16.2 16 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0376901791605284 0.0724771958722053 1.26457307060755 0.476190476190476 16.2 16 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0376901791605284 0.0724771958722053 1.26457307060755 0.476190476190476 16.2 16 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0376901791605284 0.0724771958722053 1.26457307060755 0.476190476190476 16.2 16 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00512619224039982 0.0131670966752508 1.26141163793103 0.475 16.2 16 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.90141267412613e-25 5.3651617194473e-23 1.26036520925177 0.474605954465849 16.2 16 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00660189266728973 0.0160315584736404 1.25791742286751 0.473684210526316 16.2 16 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0495307833417071 0.0907108168536025 1.25791742286751 0.473684210526316 16.2 16 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0495307833417071 0.0907108168536025 1.25791742286751 0.473684210526316 16.2 16 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0495307833417071 0.0907108168536025 1.25791742286751 0.473684210526316 16.2 16 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000248665944702188 0.000916714091479828 1.25403496168582 0.472222222222222 16.2 16 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00851155020730663 0.0199209472779561 1.25403496168582 0.472222222222222 16.2 16 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0016076666895292 0.00473645900455496 1.25264313597918 0.471698113207547 16.2 16 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.0653678507808989 0.11385367400394 1.24969574036511 0.470588235294118 16.2 16 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0653678507808989 0.11385367400394 1.24969574036511 0.470588235294118 16.2 16 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0653678507808989 0.11385367400394 1.24969574036511 0.470588235294118 16.2 16 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0653678507808989 0.11385367400394 1.24969574036511 0.470588235294118 16.2 16 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.000167137474897607 0.000667925319783391 1.24376364033173 0.468354430379747 16.2 16 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.95537483854857e-11 5.06686553645134e-10 1.24349685276409 0.468253968253968 16.2 16 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.95537483854857e-11 5.06686553645134e-10 1.24349685276409 0.468253968253968 16.2 16 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.95537483854857e-11 5.06686553645134e-10 1.24349685276409 0.468253968253968 16.2 16 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0183804575660759 0.039331415212821 1.2392816091954 0.466666666666667 16.2 16 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0867181388633753 0.142494124252405 1.2392816091954 0.466666666666667 16.2 16 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0867181388633753 0.142494124252405 1.2392816091954 0.466666666666667 16.2 16 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.80899225873068e-05 9.53405920064353e-05 1.2392816091954 0.466666666666667 16.2 16 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 8.83055343673198e-05 0.000371771524865965 1.23726978840125 0.465909090909091 16.2 16 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0238306909367942 0.0478294403428184 1.23295874384236 0.464285714285714 16.2 16 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00713634005723693 0.0169816252532578 1.23064550042052 0.463414634146341 16.2 16 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00713634005723693 0.0169816252532578 1.23064550042052 0.463414634146341 16.2 16 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.16439406266928e-08 1.22735759346547e-07 1.22670007001575 0.461928934010152 16.2 16 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0309545699550272 0.0603402096520598 1.22566312997347 0.461538461538462 16.2 16 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0309545699550272 0.0603402096520598 1.22566312997347 0.461538461538462 16.2 16 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.115793977928914 0.184932469801172 1.22566312997347 0.461538461538462 16.2 16 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.115793977928914 0.184932469801172 1.22566312997347 0.461538461538462 16.2 16 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.115793977928914 0.184932469801172 1.22566312997347 0.461538461538462 16.2 16 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.000597788647912275 0.00198287469925214 1.21715158045977 0.458333333333333 16.2 16 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0402932030467833 0.0754818987359308 1.21715158045977 0.458333333333333 16.2 16 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0402932030467833 0.0754818987359308 1.21715158045977 0.458333333333333 16.2 16 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0402932030467833 0.0754818987359308 1.21715158045977 0.458333333333333 16.2 16 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0402932030467833 0.0754818987359308 1.21715158045977 0.458333333333333 16.2 16 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0151850852983277 0.0332948788590451 1.21399014778325 0.457142857142857 16.2 16 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00594230484545535 0.0149420405880523 1.21234070464768 0.456521739130435 16.2 16 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.019568675365376 0.0414378348882887 1.20709247648903 0.454545454545455 16.2 16 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.019568675365376 0.0414378348882887 1.20709247648903 0.454545454545455 16.2 16 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00303001664879019 0.00821278798329228 1.20709247648903 0.454545454545455 16.2 16 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.155925995060155 0.233560727337474 1.20709247648903 0.454545454545455 16.2 16 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.19149880971945e-06 7.92291030948963e-06 1.20094168679991 0.452229299363057 16.2 16 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00198104831670048 0.0056963047587732 1.19930478309232 0.451612903225806 16.2 16 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0687976217060129 0.118521810759875 1.19502155172414 0.45 16.2 16 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.44613929539813e-22 3.72168012785384e-20 1.19357604440393 0.44945567651633 16.2 16 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00628176187211525 0.0153088978157665 1.19231175228712 0.448979591836735 16.2 16 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0326090735541433 0.063478401733989 1.19044292508918 0.448275862068966 16.2 16 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 4.55040771317306e-13 9.81095481188677e-12 1.18579084455099 0.446524064171123 16.2 16 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 8.04495254811754e-05 0.000342753517244648 1.18295062695925 0.445454545454545 16.2 16 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000707566487555382 0.00228833434498025 1.18026819923372 0.444444444444444 16.2 16 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0205239133711446 0.0427606569943467 1.18026819923372 0.444444444444444 16.2 16 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0205239133711446 0.0427606569943467 1.18026819923372 0.444444444444444 16.2 16 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0903194833448842 0.148240628373437 1.18026819923372 0.444444444444444 16.2 16 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.36472173098516e-08 3.14999935736308e-07 1.17894502860677 0.443946188340807 16.2 16 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 7.20069530147772e-48 2.5616473535007e-45 1.17264864985196 0.441575209812782 16.2 16 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0263439809615573 0.0527992745187269 1.17158975659229 0.441176470588235 16.2 16 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.054631748778506 0.0976645458691132 1.16846551724138 0.44 16.2 16 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000167568052819867 0.000667925319783391 1.16648001933613 0.439252336448598 16.2 16 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0166621643293572 0.0360886755565834 1.16587468460892 0.439024390243902 16.2 16 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0106340829858301 0.0243284567344633 1.16182650862069 0.4375 16.2 16 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0106340829858301 0.0243284567344633 1.16182650862069 0.4375 16.2 16 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0106340829858301 0.0243284567344633 1.16182650862069 0.4375 16.2 16 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0106340829858301 0.0243284567344633 1.16182650862069 0.4375 16.2 16 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.119036313005006 0.188839100787205 1.16182650862069 0.4375 16.2 16 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.119036313005006 0.188839100787205 1.16182650862069 0.4375 16.2 16 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.119036313005006 0.188839100787205 1.16182650862069 0.4375 16.2 16 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 6.19915999829212e-06 3.48672121643071e-05 1.15673524434102 0.43558282208589 16.2 16 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0135207628085279 0.0301568110917479 1.15461019490255 0.434782608695652 16.2 16 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00186481965175687 0.00538263359929011 1.15309097096189 0.434210526315789 16.2 16 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0434897798979597 0.081215166397371 1.15076149425287 0.433333333333333 16.2 16 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 3.442312114487e-05 0.00016429180269087 1.14887808755197 0.432624113475177 16.2 16 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0138983238211161 0.0306625035619353 1.1381157635468 0.428571428571429 16.2 16 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 1.60675520269319e-05 8.49967529157029e-05 1.1381157635468 0.428571428571429 16.2 16 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.021853602205369 0.0448282747935022 1.1381157635468 0.428571428571429 16.2 16 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0559360056970085 0.099745533968475 1.1381157635468 0.428571428571429 16.2 16 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0559360056970085 0.099745533968475 1.1381157635468 0.428571428571429 16.2 16 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0921282036151261 0.15051484930462 1.1381157635468 0.428571428571429 16.2 16 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.157618093595005 0.234613543081267 1.1381157635468 0.428571428571429 16.2 16 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.157618093595005 0.234613543081267 1.1381157635468 0.428571428571429 16.2 16 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.157618093595005 0.234613543081267 1.1381157635468 0.428571428571429 16.2 16 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.157618093595005 0.234613543081267 1.1381157635468 0.428571428571429 16.2 16 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.157618093595005 0.234613543081267 1.1381157635468 0.428571428571429 16.2 16 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00371787443720466 0.00998214212102309 1.1381157635468 0.428571428571429 16.2 16 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00371787443720466 0.00998214212102309 1.1381157635468 0.428571428571429 16.2 16 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 2.00158592866636e-05 0.000103197709293197 1.13572977662112 0.427672955974843 16.2 16 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 2.00158592866636e-05 0.000103197709293197 1.13572977662112 0.427672955974843 16.2 16 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 2.0555580008367e-05 0.000105217950906138 1.13109035759898 0.425925925925926 16.2 16 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00587647629517326 0.0148529764973917 1.12661964472309 0.424242424242424 16.2 16 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0443497979598269 0.0827126638228488 1.12661964472309 0.424242424242424 16.2 16 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0222796290280138 0.0454210775169966 1.12125478927203 0.422222222222222 16.2 16 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.4418542580555e-06 3.60896008236731e-05 1.12033270474138 0.421875 16.2 16 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0179062383829369 0.0385485283190911 1.11535344827586 0.42 16.2 16 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00168305388077973 0.00494831750485445 1.11364015572859 0.419354838709677 16.2 16 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0566661117526226 0.100794846279977 1.11364015572859 0.419354838709677 16.2 16 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0566661117526226 0.100794846279977 1.11364015572859 0.419354838709677 16.2 16 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.209896243662461 0.300183271087117 1.10650143678161 0.416666666666667 16.2 16 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.209896243662461 0.300183271087117 1.10650143678161 0.416666666666667 16.2 16 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0356518533667001 0.0689301458434976 1.10110386879731 0.414634146341463 16.2 16 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0284432756269115 0.0566080856183148 1.09687968515742 0.41304347826087 16.2 16 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000121321373756014 0.000491852748874095 1.09650723025584 0.412903225806452 16.2 16 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.156604236561881 0.234329998556842 1.09348377281947 0.411764705882353 16.2 16 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0450575449790482 0.0830381183067954 1.0894783377542 0.41025641025641 16.2 16 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0450575449790482 0.0830381183067954 1.0894783377542 0.41025641025641 16.2 16 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00407387346107928 0.0108155259983504 1.08638322884013 0.409090909090909 16.2 16 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.119510070809295 0.189379544277981 1.08638322884013 0.409090909090909 16.2 16 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0285601063029392 0.0567612168562604 1.08391977480647 0.408163265306122 16.2 16 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0924951826115111 0.1507682071663 1.08191251596424 0.407407407407407 16.2 16 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0924951826115111 0.1507682071663 1.08191251596424 0.407407407407407 16.2 16 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0147324315812235 0.0324523995976487 1.07883890086207 0.40625 16.2 16 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.072286307812111 0.123485493417328 1.07883890086207 0.40625 16.2 16 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00145866729084466 0.00433336859054688 1.06659482758621 0.401639344262295 16.2 16 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.000789242733650734 0.00251822459365296 1.06611817266549 0.401459854014599 16.2 16 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.000643761166200585 0.00212545740023998 1.06598166585721 0.401408450704225 16.2 16 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0916769391428821 0.149949752184277 1.06224137931034 0.4 16.2 16 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.118126603394171 0.188024783702355 1.06224137931034 0.4 16.2 16 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.154108239592831 0.233560727337474 1.06224137931034 0.4 16.2 16 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.204884730082757 0.296593052805456 1.06224137931034 0.4 16.2 16 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.204884730082757 0.296593052805456 1.06224137931034 0.4 16.2 16 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.204884730082757 0.296593052805456 1.06224137931034 0.4 16.2 16 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.000789267862803388 0.00251822459365296 1.06224137931034 0.4 16.2 16 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.08411433196539e-09 1.29638209612332e-08 1.05687652385928 0.397979797979798 16.2 16 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00118321416106602 0.00358236968339776 1.05443078093306 0.397058823529412 16.2 16 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.028297187726129 0.0563962158743439 1.05308412604043 0.396551724137931 16.2 16 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.028297187726129 0.0563962158743439 1.05308412604043 0.396551724137931 16.2 16 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.028297187726129 0.0563962158743439 1.05308412604043 0.396551724137931 16.2 16 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0354150042796111 0.0685653756324987 1.05222023422251 0.39622641509434 16.2 16 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0444661673044211 0.0827128837571126 1.05117636494253 0.395833333333333 16.2 16 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.0444661673044211 0.0827128837571126 1.05117636494253 0.395833333333333 16.2 16 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00143953292107116 0.00428547143657797 1.04673420588976 0.394160583941606 16.2 16 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.090445039216096 0.148275680650351 1.04614681295716 0.393939393939394 16.2 16 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.116151120615012 0.185087396008021 1.04327278325123 0.392857142857143 16.2 16 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.116151120615012 0.185087396008021 1.04327278325123 0.392857142857143 16.2 16 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.150771903147275 0.229218395489928 1.03914917541229 0.391304347826087 16.2 16 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.150771903147275 0.229218395489928 1.03914917541229 0.391304347826087 16.2 16 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.04341142197423 0.0811753659255314 1.0327346743295 0.388888888888889 16.2 16 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.198785443154515 0.288644577151913 1.0327346743295 0.388888888888889 16.2 16 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.146958847234867 0.226322986596553 1.02138594164456 0.384615384615385 16.2 16 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.268710159745927 0.375376486802367 1.02138594164456 0.384615384615385 16.2 16 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00106952009428775 0.00331574530320583 1.0190106255012 0.383720930232558 16.2 16 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0833431190732128 0.137265345418034 1.00322796934866 0.377777777777778 16.2 16 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.256393780329408 0.359810995472138 0.995851293103448 0.375 16.2 16 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.256393780329408 0.359810995472138 0.995851293103448 0.375 16.2 16 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.256393780329408 0.359810995472138 0.995851293103448 0.375 16.2 16 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.256393780329408 0.359810995472138 0.995851293103448 0.375 16.2 16 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.185597848106897 0.270046766724044 0.995851293103448 0.375 16.2 16 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.185597848106897 0.270046766724044 0.995851293103448 0.375 16.2 16 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.134457508417421 0.207744879997818 0.986366995073891 0.371428571428571 16.2 16 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.178996297013312 0.265601387539043 0.983556832694764 0.37037037037037 16.2 16 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000558833999840241 0.00188440943548024 0.978928329952671 0.368627450980392 16.2 16 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.244752956072422 0.34551930207446 0.978380217785844 0.368421052631579 16.2 16 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.172534374526166 0.256280182620808 0.973721264367816 0.366666666666667 16.2 16 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.12608555537812 0.199577024808748 0.971562237174096 0.365853658536585 16.2 16 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.166259618151433 0.247217802120678 0.965673981191223 0.363636363636364 16.2 16 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0911804833928279 0.149309353127726 0.965673981191222 0.363636363636364 16.2 16 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0178419307983972 0.0384682841304837 0.96187211512354 0.362204724409449 16.2 16 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0382576124342631 0.0734690721915742 0.960537417461482 0.361702127659574 16.2 16 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.110387129377064 0.176892888630138 0.952008783344177 0.358490566037736 16.2 16 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.330427974274218 0.434966704340621 0.948429802955665 0.357142857142857 16.2 16 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.330427974274218 0.434966704340621 0.948429802955665 0.357142857142857 16.2 16 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.330427974274218 0.434966704340621 0.948429802955665 0.357142857142857 16.2 16 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.138160599140518 0.21300382727731 0.940526221264368 0.354166666666667 16.2 16 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.278105203414332 0.380889032202689 0.923688155922039 0.347826086956522 16.2 16 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.264098904681714 0.369894430474487 0.919247347480106 0.346153846153846 16.2 16 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.251291144786673 0.354046830724194 0.915725326991677 0.344827586206897 16.2 16 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.137169076971797 0.211704551551917 0.914224137931035 0.344262295081967 16.2 16 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.250434497939078 0.353189584308532 0.885201149425287 0.333333333333333 16.2 16 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.290669529916927 0.396190365011291 0.885201149425287 0.333333333333333 16.2 16 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.3442175742449 0.452282186657888 0.885201149425287 0.333333333333333 16.2 16 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.393199596369948 0.510979932086243 0.885201149425287 0.333333333333333 16.2 16 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0279163108734274 0.0558718851939342 0.874787018255578 0.329411764705882 16.2 16 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0403135931407642 0.0754818987359308 0.863871001246365 0.325301204819277 16.2 16 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.072429907732217 0.123582444487943 0.861276794035415 0.324324324324324 16.2 16 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.331538683136096 0.436025458505236 0.856646273637375 0.32258064516129 16.2 16 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.35057964649128 0.459792476458149 0.853586822660098 0.321428571428571 16.2 16 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.35057964649128 0.459792476458149 0.853586822660098 0.321428571428571 16.2 16 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.371798155331692 0.4862764476443 0.849793103448276 0.32 16.2 16 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.2124165368878 0.300465936373101 0.84354462474645 0.317647058823529 16.2 16 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.2124165368878 0.300465936373101 0.84354462474645 0.317647058823529 16.2 16 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.423193623825806 0.543996862424681 0.838611615245009 0.315789473684211 16.2 16 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.21811878919132 0.308225458807595 0.831552594914664 0.313131313131313 16.2 16 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.455384058206557 0.582744168010729 0.829876077586207 0.3125 16.2 16 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.295769409799636 0.399417224270403 0.827155172413793 0.311475409836066 16.2 16 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.277496268110755 0.380421184510217 0.810657894736842 0.305263157894737 16.2 16 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.32445203382785 0.428288723689268 0.808227136431784 0.304347826086957 16.2 16 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.311458948370622 0.411519111914016 0.806765604539502 0.30379746835443 16.2 16 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.415663853404583 0.536232764449182 0.804728317659352 0.303030303030303 16.2 16 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.259036017717389 0.363160840602802 0.793442493692178 0.298780487804878 16.2 16 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.433717113807999 0.555517059359841 0.789503727865797 0.297297297297297 16.2 16 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.433717113807999 0.555517059359841 0.789503727865797 0.297297297297297 16.2 16 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00769604928533524 0.018282935113576 0.788908536585366 0.297073170731707 16.2 16 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.515617232223355 0.639131813113095 0.781059837728195 0.294117647058824 16.2 16 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.484488526495073 0.602646130421756 0.770981646273637 0.290322580645161 16.2 16 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.47803759421211 0.595142166722513 0.758743842364532 0.285714285714286 16.2 16 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.527967274048002 0.648229017230636 0.746888469827586 0.28125 16.2 16 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.49627647373107 0.615694352327212 0.739188588695343 0.278350515463918 16.2 16 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.572837729512297 0.690218534374258 0.737667624521073 0.277777777777778 16.2 16 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.572837729512297 0.690218534374258 0.737667624521073 0.277777777777778 16.2 16 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.572837729512297 0.690218534374258 0.737667624521073 0.277777777777778 16.2 16 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.536647538665588 0.658318489242355 0.734528613352898 0.276595744680851 16.2 16 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.583872460935953 0.702919214815449 0.724255485893417 0.272727272727273 16.2 16 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.593614125568955 0.713439949902553 0.714970159151194 0.269230769230769 16.2 16 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.589564316388174 0.709171616416206 0.710654443904808 0.267605633802817 16.2 16 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.617932474529555 0.718984391868812 0.698843012704174 0.263157894736842 16.2 16 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.643421355529955 0.747419256260511 0.6853170189099 0.258064516129032 16.2 16 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.698157007953745 0.805740001880112 0.672304670449585 0.253164556962025 16.2 16 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.675459342554068 0.783995631692039 0.663900862068965 0.25 16.2 16 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.728304279775704 0.829101592096661 0.652253478523896 0.245614035087719 16.2 16 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.717341102056292 0.822699325670494 0.641007728894174 0.241379310344828 16.2 16 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.806765302054314 0.896195960049405 0.638366213527852 0.240384615384615 16.2 16 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.777411395991859 0.877285024977331 0.617582197273456 0.232558139534884 16.2 16 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.760185530445794 0.859208903752474 0.603546238244514 0.227272727272727 16.2 16 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.760185530445794 0.859208903752474 0.603546238244514 0.227272727272727 16.2 16 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.972988811632967 1 0.597510775862069 0.225 16.2 16 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.855349439902313 0.938444296824203 0.590134099616858 0.222222222222222 16.2 16 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.994261231762456 1 0.581768796658372 0.219072164948454 16.2 16 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.83827124564451 0.928020136041173 0.563309822361546 0.212121212121212 16.2 16 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.984753438806063 1 0.562938979818846 0.211981566820276 16.2 16 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.82704654760656 0.91729324804687 0.553250718390805 0.208333333333333 16.2 16 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.845187885080935 0.933766179874635 0.549435196195006 0.206896551724138 16.2 16 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.98819501167744 1 0.542542639970337 0.204301075268817 16.2 16 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.877897964968838 0.962441297496654 0.510692970822281 0.192307692307692 16.2 16 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99698844417539 1 0.497925646551724 0.1875 16.2 16 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.934172696290981 1 0.468635902636917 0.176470588235294 16.2 16 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.945172130417844 1 0.455246305418719 0.171428571428571 16.2 16 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.942357456734494 1 0.442600574712644 0.166666666666667 16.2 16 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.996800397508142 1 0.442600574712644 0.166666666666667 16.2 16 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.42364790526651 0.159529806884971 16.2 16 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.961302136818281 1 0.414938038793103 0.15625 16.2 16 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.988514972301018 1 0.387275502873563 0.145833333333333 16.2 16 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999562839835452 1 0.354080459770115 0.133333333333333 16.2 16 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.343355599551038 0.129294755877034 16.2 16 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 8.73436996230378e-06 4.10198298889712e-05 1.88248789191945 1 16.1 16 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 7.26481749520178e-05 0.000299647399874554 1.88248789191945 1 16.1 16 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000604117395676257 0.00198078123052376 1.88248789191945 1 16.1 16 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.000604117395676257 0.00198078123052376 1.88248789191945 1 16.1 16 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.000604117395676257 0.00198078123052376 1.88248789191945 1 16.1 16 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.000604117395676257 0.00198078123052376 1.88248789191945 1 16.1 16 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.000604117395676257 0.00198078123052376 1.88248789191945 1 16.1 16 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 2.51906984353746e-05 0.000109958171391221 1.88248789191945 1 16.1 16 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.000209500510302919 0.000766373332033559 1.88248789191945 1 16.1 16 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.000209500510302919 0.000766373332033559 1.88248789191945 1 16.1 16 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000209500510302919 0.000766373332033559 1.88248789191945 1 16.1 16 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.000209500510302919 0.000766373332033559 1.88248789191945 1 16.1 16 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00174194115672424 0.00491821878178293 1.88248789191945 1 16.1 16 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00174194115672424 0.00491821878178293 1.88248789191945 1 16.1 16 1 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.00174194115672424 0.00491821878178293 1.88248789191945 1 16.1 16 1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.00502251802915076 0.0124296402704027 1.88248789191945 1 16.1 16 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00502251802915076 0.0124296402704027 1.88248789191945 1 16.1 16 1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00502251802915076 0.0124296402704027 1.88248789191945 1 16.1 16 1 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00502251802915076 0.0124296402704027 1.88248789191945 1 16.1 16 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00502251802915076 0.0124296402704027 1.88248789191945 1 16.1 16 1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.00502251802915076 0.0124296402704027 1.88248789191945 1 16.1 16 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00502251802915076 0.0124296402704027 1.88248789191945 1 16.1 16 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 2.676926772827e-05 0.000116491339380209 1.73768113100257 0.923076923076923 16.1 16 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.51596377943705e-09 3.45049410906133e-08 1.73188886056589 0.92 16.1 16 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000189753983166083 0.000701350436481393 1.71135262901768 0.909090909090909 16.1 16 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.000499765463601806 0.00166549474169876 1.6942391027275 0.9 16.1 16 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000499765463601806 0.00166549474169876 1.6942391027275 0.9 16.1 16 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.18203678598115e-09 1.1845340467966e-08 1.68774776516916 0.896551724137931 16.1 16 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00130431919311013 0.00380601884450528 1.67332257059507 0.888888888888889 16.1 16 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00130431919311013 0.00380601884450528 1.67332257059507 0.888888888888889 16.1 16 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00130431919311013 0.00380601884450528 1.67332257059507 0.888888888888889 16.1 16 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 7.91972573782428e-09 6.66906966816996e-08 1.67332257059507 0.888888888888889 16.1 16 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 7.82584043337671e-06 3.71205697889835e-05 1.66101872816422 0.882352941176471 16.1 16 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 2.0006019616576e-05 8.92431533366386e-05 1.64717690542952 0.875 16.1 16 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 2.0006019616576e-05 8.92431533366386e-05 1.64717690542952 0.875 16.1 16 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00336643559328961 0.00867832943704913 1.64717690542952 0.875 16.1 16 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00336643559328961 0.00867832943704913 1.64717690542952 0.875 16.1 16 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00336643559328961 0.00867832943704913 1.64717690542952 0.875 16.1 16 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00336643559328961 0.00867832943704913 1.64717690542952 0.875 16.1 16 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00336643559328961 0.00867832943704913 1.64717690542952 0.875 16.1 16 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00336643559328961 0.00867832943704913 1.64717690542952 0.875 16.1 16 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.66586822343419e-10 3.44866407449713e-09 1.62103124026397 0.861111111111111 16.1 16 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000127583845926548 0.000500142734858064 1.61356105021667 0.857142857142857 16.1 16 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000127583845926548 0.000500142734858064 1.61356105021667 0.857142857142857 16.1 16 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00856888372301217 0.0198591555990982 1.61356105021667 0.857142857142857 16.1 16 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00856888372301217 0.0198591555990982 1.61356105021667 0.857142857142857 16.1 16 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00856888372301217 0.0198591555990982 1.61356105021667 0.857142857142857 16.1 16 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.00856888372301217 0.0198591555990982 1.61356105021667 0.857142857142857 16.1 16 1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.00856888372301217 0.0198591555990982 1.61356105021667 0.857142857142857 16.1 16 1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.00856888372301217 0.0198591555990982 1.61356105021667 0.857142857142857 16.1 16 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00856888372301217 0.0198591555990982 1.61356105021667 0.857142857142857 16.1 16 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 2.12160533015337e-06 1.17017224217374e-05 1.61356105021667 0.857142857142857 16.1 16 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.12160533015337e-06 1.17017224217374e-05 1.61356105021667 0.857142857142857 16.1 16 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 5.27128704542934e-06 2.56008241148326e-05 1.60011470813153 0.85 16.1 16 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000317526468041401 0.0011156547259825 1.59287437008569 0.846153846153846 16.1 16 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.000317526468041401 0.0011156547259825 1.59287437008569 0.846153846153846 16.1 16 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.000317526468041401 0.0011156547259825 1.59287437008569 0.846153846153846 16.1 16 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 5.56586952149854e-07 3.5676722203119e-06 1.58128982921234 0.84 16.1 16 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.09376598128206e-09 1.10385034848537e-08 1.5772195851217 0.837837837837838 16.1 16 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 5.94647133301971e-08 4.23786723927887e-07 1.56873990993287 0.833333333333333 16.1 16 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 1.35545267247505e-06 8.05533730840284e-06 1.56873990993287 0.833333333333333 16.1 16 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000781018175498894 0.00242661323959591 1.56873990993287 0.833333333333333 16.1 16 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000781018175498894 0.00242661323959591 1.56873990993287 0.833333333333333 16.1 16 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.000781018175498894 0.00242661323959591 1.56873990993287 0.833333333333333 16.1 16 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000781018175498894 0.00242661323959591 1.56873990993287 0.833333333333333 16.1 16 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000781018175498894 0.00242661323959591 1.56873990993287 0.833333333333333 16.1 16 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.000781018175498894 0.00242661323959591 1.56873990993287 0.833333333333333 16.1 16 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000781018175498894 0.00242661323959591 1.56873990993287 0.833333333333333 16.1 16 1 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0214254023912834 0.0441860110185453 1.56873990993287 0.833333333333333 16.1 16 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0214254023912834 0.0441860110185453 1.56873990993287 0.833333333333333 16.1 16 1 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.0214254023912834 0.0441860110185453 1.56873990993287 0.833333333333333 16.1 16 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0214254023912834 0.0441860110185453 1.56873990993287 0.833333333333333 16.1 16 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 6.40869289774479e-09 6.20378911121825e-08 1.55977568187612 0.828571428571429 16.1 16 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 7.68468558048395e-05 0.000312437359457962 1.55028414628661 0.823529411764706 16.1 16 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 7.68468558048395e-05 0.000312437359457962 1.55028414628661 0.823529411764706 16.1 16 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00189481712556256 0.00523558207703986 1.54021736611591 0.818181818181818 16.1 16 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000183952861524678 0.000681679484243792 1.52952141218455 0.8125 16.1 16 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000183952861524678 0.000681679484243792 1.52952141218455 0.8125 16.1 16 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000183952861524678 0.000681679484243792 1.52952141218455 0.8125 16.1 16 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000183952861524678 0.000681679484243792 1.52952141218455 0.8125 16.1 16 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.94097489104196e-06 1.07890908982528e-05 1.52047098962725 0.807692307692308 16.1 16 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 1.94097489104196e-06 1.07890908982528e-05 1.52047098962725 0.807692307692308 16.1 16 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.59430344680091e-14 5.27603210418069e-13 1.51722904721866 0.805970149253731 16.1 16 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 4.55091555377585e-06 2.28647929627512e-05 1.50599031353556 0.8 16.1 16 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 4.55091555377585e-06 2.28647929627512e-05 1.50599031353556 0.8 16.1 16 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 4.55091555377585e-06 2.28647929627512e-05 1.50599031353556 0.8 16.1 16 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 7.16033115913608e-12 1.2897659796773e-10 1.50599031353556 0.8 16.1 16 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 4.80264106738366e-07 3.10643556313043e-06 1.50599031353556 0.8 16.1 16 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000434935019735357 0.00147711821738285 1.50599031353556 0.8 16.1 16 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000434935019735357 0.00147711821738285 1.50599031353556 0.8 16.1 16 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000434935019735357 0.00147711821738285 1.50599031353556 0.8 16.1 16 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00452253411114343 0.0114308455420197 1.50599031353556 0.8 16.1 16 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00452253411114343 0.0114308455420197 1.50599031353556 0.8 16.1 16 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00452253411114343 0.0114308455420197 1.50599031353556 0.8 16.1 16 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.49823868572196e-10 4.3666610963003e-09 1.49030291443623 0.791666666666667 16.1 16 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.05747030278876e-05 4.91758248649804e-05 1.49030291443623 0.791666666666667 16.1 16 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 1.05747030278876e-05 4.91758248649804e-05 1.49030291443623 0.791666666666667 16.1 16 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000102104196971012 0.000403595200804862 1.48617465151535 0.789473684210526 16.1 16 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 8.79959817221982e-11 1.23186066032731e-09 1.48426929939803 0.788461538461538 16.1 16 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0010139827491292 0.00310969278450614 1.47909762936528 0.785714285714286 16.1 16 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0010139827491292 0.00310969278450614 1.47909762936528 0.785714285714286 16.1 16 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0010139827491292 0.00310969278450614 1.47909762936528 0.785714285714286 16.1 16 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 2.43321191062189e-05 0.000106537247655845 1.47325139367609 0.782608695652174 16.1 16 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000234670826187955 0.000851879045064947 1.46415724927068 0.777777777777778 16.1 16 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000234670826187955 0.000851879045064947 1.46415724927068 0.777777777777778 16.1 16 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0105838429939178 0.023906045365627 1.46415724927068 0.777777777777778 16.1 16 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0105838429939178 0.023906045365627 1.46415724927068 0.777777777777778 16.1 16 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0105838429939178 0.023906045365627 1.46415724927068 0.777777777777778 16.1 16 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0105838429939178 0.023906045365627 1.46415724927068 0.777777777777778 16.1 16 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0105838429939178 0.023906045365627 1.46415724927068 0.777777777777778 16.1 16 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0105838429939178 0.023906045365627 1.46415724927068 0.777777777777778 16.1 16 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0105838429939178 0.023906045365627 1.46415724927068 0.777777777777778 16.1 16 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0105838429939178 0.023906045365627 1.46415724927068 0.777777777777778 16.1 16 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 6.32795712391346e-16 2.81396343354027e-14 1.46169648078451 0.776470588235294 16.1 16 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 6.32795712391346e-16 2.81396343354027e-14 1.46169648078451 0.776470588235294 16.1 16 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 6.32795712391346e-16 2.81396343354027e-14 1.46169648078451 0.776470588235294 16.1 16 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.7951944491789e-08 2.87263920275616e-07 1.45892811623757 0.775 16.1 16 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 5.04488646564949e-14 1.30524971647622e-12 1.45579063641771 0.773333333333333 16.1 16 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 5.04488646564949e-14 1.30524971647622e-12 1.45579063641771 0.773333333333333 16.1 16 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 5.04488646564949e-14 1.30524971647622e-12 1.45579063641771 0.773333333333333 16.1 16 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 5.04488646564949e-14 1.30524971647622e-12 1.45579063641771 0.773333333333333 16.1 16 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 5.04488646564949e-14 1.30524971647622e-12 1.45579063641771 0.773333333333333 16.1 16 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 3.47670455687401e-07 2.32269980489752e-06 1.452204945195 0.771428571428571 16.1 16 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 5.78246036530259e-10 6.97325516934372e-09 1.44806760916881 0.769230769230769 16.1 16 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 1.32507177628887e-05 6.04351646685599e-05 1.44806760916881 0.769230769230769 16.1 16 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00232599053369055 0.00630454196084123 1.44806760916881 0.769230769230769 16.1 16 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00232599053369055 0.00630454196084123 1.44806760916881 0.769230769230769 16.1 16 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00232599053369055 0.00630454196084123 1.44806760916881 0.769230769230769 16.1 16 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00232599053369055 0.00630454196084123 1.44806760916881 0.769230769230769 16.1 16 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.52559117961542e-13 5.61549413842615e-12 1.44410030065054 0.767123287671233 16.1 16 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.59136820807364e-11 5.55490973922695e-10 1.44324071713824 0.766666666666667 16.1 16 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.59136820807364e-11 5.55490973922695e-10 1.44324071713824 0.766666666666667 16.1 16 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.59136820807364e-11 5.55490973922695e-10 1.44324071713824 0.766666666666667 16.1 16 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.59136820807364e-11 5.55490973922695e-10 1.44324071713824 0.766666666666667 16.1 16 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.59136820807364e-11 5.55490973922695e-10 1.44324071713824 0.766666666666667 16.1 16 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.59136820807364e-11 5.55490973922695e-10 1.44324071713824 0.766666666666667 16.1 16 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.59136820807364e-11 5.55490973922695e-10 1.44324071713824 0.766666666666667 16.1 16 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 3.20078730430521e-06 1.66221438294309e-05 1.44324071713824 0.766666666666667 16.1 16 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 3.20078730430521e-06 1.66221438294309e-05 1.44324071713824 0.766666666666667 16.1 16 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.59096640144088e-14 5.27603210418069e-13 1.44091665801242 0.765432098765432 16.1 16 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.59096640144088e-14 5.27603210418069e-13 1.44091665801242 0.765432098765432 16.1 16 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.000532047380114151 0.00176893322874401 1.43954956440899 0.764705882352941 16.1 16 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000124619274223054 0.000491227776231039 1.43427648908149 0.761904761904762 16.1 16 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.15630653935894e-08 9.402424031473e-08 1.43232774385175 0.760869565217391 16.1 16 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 2.96500300292413e-05 0.000127084315456658 1.43069079785878 0.76 16.1 16 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.96500300292413e-05 0.000127084315456658 1.43069079785878 0.76 16.1 16 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.96500300292413e-05 0.000127084315456658 1.43069079785878 0.76 16.1 16 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 7.80582094303814e-14 1.85128053365721e-12 1.42973763943249 0.759493670886076 16.1 16 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 7.80582094303814e-14 1.85128053365721e-12 1.42973763943249 0.759493670886076 16.1 16 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7.80582094303814e-14 1.85128053365721e-12 1.42973763943249 0.759493670886076 16.1 16 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.95770653749687e-14 6.05612261490879e-13 1.4288763516979 0.759036144578313 16.1 16 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.73036989731766e-06 9.81002535411567e-06 1.42612719084807 0.757575757575758 16.1 16 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.0364541614274e-07 7.26539050104037e-07 1.42334450364641 0.75609756097561 16.1 16 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.0364541614274e-07 7.26539050104037e-07 1.42334450364641 0.75609756097561 16.1 16 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.49252065236755e-15 6.43592996460308e-14 1.41692637026195 0.752688172043011 16.1 16 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.60049000914269e-08 4.0454300928985e-07 1.41186591893959 0.75 16.1 16 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.60049000914269e-08 4.0454300928985e-07 1.41186591893959 0.75 16.1 16 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 9.2871671958041e-07 5.64770894001249e-06 1.41186591893959 0.75 16.1 16 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0011878814943674 0.0036041692249143 1.41186591893959 0.75 16.1 16 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0241762281121798 0.0482507329644206 1.41186591893959 0.75 16.1 16 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0241762281121798 0.0482507329644206 1.41186591893959 0.75 16.1 16 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0241762281121798 0.0482507329644206 1.41186591893959 0.75 16.1 16 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0241762281121798 0.0482507329644206 1.41186591893959 0.75 16.1 16 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.0241762281121798 0.0482507329644206 1.41186591893959 0.75 16.1 16 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0241762281121798 0.0482507329644206 1.41186591893959 0.75 16.1 16 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0241762281121798 0.0482507329644206 1.41186591893959 0.75 16.1 16 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0241762281121798 0.0482507329644206 1.41186591893959 0.75 16.1 16 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 6.56043673412132e-05 0.000271380856763216 1.41186591893959 0.75 16.1 16 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 6.56043673412132e-05 0.000271380856763216 1.41186591893959 0.75 16.1 16 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000276757456386778 0.000987032231675152 1.41186591893959 0.75 16.1 16 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000276757456386778 0.000987032231675152 1.41186591893959 0.75 16.1 16 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00523621397575357 0.012891232677331 1.41186591893959 0.75 16.1 16 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00523621397575357 0.012891232677331 1.41186591893959 0.75 16.1 16 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00523621397575357 0.012891232677331 1.41186591893959 0.75 16.1 16 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.15968654002022e-12 1.2897659796773e-10 1.40523744044691 0.746478873239437 16.1 16 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.45683306196869e-09 6.66906966816996e-08 1.40263803711645 0.745098039215686 16.1 16 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.45683306196869e-09 6.66906966816996e-08 1.40263803711645 0.745098039215686 16.1 16 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 9.96493951845692e-10 1.01286492391173e-08 1.39563757504373 0.741379310344828 16.1 16 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 9.96493951845692e-10 1.01286492391173e-08 1.39563757504373 0.741379310344828 16.1 16 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.32002593565328e-13 3.07933919087643e-12 1.39525573165795 0.741176470588235 16.1 16 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 3.43644366395637e-05 0.00014684862864294 1.39443547549589 0.740740740740741 16.1 16 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.85807451303955e-16 1.40242759726044e-14 1.39376507382498 0.740384615384615 16.1 16 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.000143390193256537 0.000559025328778224 1.39140409402742 0.739130434782609 16.1 16 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000143390193256537 0.000559025328778224 1.39140409402742 0.739130434782609 16.1 16 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 2.63677556470884e-07 1.77826143534629e-06 1.38945534879769 0.738095238095238 16.1 16 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.12986383652011e-12 2.29685177052588e-11 1.38833482029059 0.7375 16.1 16 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00260636400496225 0.00691950742362181 1.38049112074093 0.733333333333333 16.1 16 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00260636400496225 0.00691950742362181 1.38049112074093 0.733333333333333 16.1 16 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00260636400496225 0.00691950742362181 1.38049112074093 0.733333333333333 16.1 16 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00260636400496225 0.00691950742362181 1.38049112074093 0.733333333333333 16.1 16 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00260636400496225 0.00691950742362181 1.38049112074093 0.733333333333333 16.1 16 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00260636400496225 0.00691950742362181 1.38049112074093 0.733333333333333 16.1 16 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.64341983561289e-30 4.17954047341905e-28 1.38049112074093 0.733333333333333 16.1 16 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.3980091022923e-07 9.7042290368875e-07 1.38049112074093 0.733333333333333 16.1 16 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.83981947272076e-08 1.45447950537869e-07 1.37566422871037 0.730769230769231 16.1 16 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.83981947272076e-08 1.45447950537869e-07 1.37566422871037 0.730769230769231 16.1 16 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 7.41624490379121e-05 0.000303256221209623 1.37566422871037 0.730769230769231 16.1 16 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 7.41624490379121e-05 0.000303256221209623 1.37566422871037 0.730769230769231 16.1 16 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 7.41624490379121e-05 0.000303256221209623 1.37566422871037 0.730769230769231 16.1 16 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000309228679763374 0.00109460798831662 1.36908210321415 0.727272727272727 16.1 16 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0115297794060258 0.0255161370058704 1.36908210321415 0.727272727272727 16.1 16 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0115297794060258 0.0255161370058704 1.36908210321415 0.727272727272727 16.1 16 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0115297794060258 0.0255161370058704 1.36908210321415 0.727272727272727 16.1 16 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0115297794060258 0.0255161370058704 1.36908210321415 0.727272727272727 16.1 16 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0115297794060258 0.0255161370058704 1.36908210321415 0.727272727272727 16.1 16 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0115297794060258 0.0255161370058704 1.36908210321415 0.727272727272727 16.1 16 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0115297794060258 0.0255161370058704 1.36908210321415 0.727272727272727 16.1 16 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0115297794060258 0.0255161370058704 1.36908210321415 0.727272727272727 16.1 16 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 3.90470771539083e-08 2.93989369259321e-07 1.36572650982391 0.725490196078431 16.1 16 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.7234372914333e-22 1.75175090407828e-20 1.3648037216416 0.725 16.1 16 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.20306068306742e-06 7.19308971430648e-06 1.3648037216416 0.725 16.1 16 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.20306068306742e-06 7.19308971430648e-06 1.3648037216416 0.725 16.1 16 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.6670205896187e-17 8.78581592232372e-16 1.36212538521001 0.723577235772358 16.1 16 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.25776660289339e-18 1.39687038083361e-16 1.36118355261868 0.723076923076923 16.1 16 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 4.87355722172028e-06 2.37502463236574e-05 1.35957458860849 0.722222222222222 16.1 16 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00130522642032226 0.00380601884450528 1.35957458860849 0.722222222222222 16.1 16 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 6.29746000009997e-07 4.01851371306828e-06 1.35714243370937 0.720930232558139 16.1 16 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000158058377571998 0.000614527517172004 1.355391282182 0.72 16.1 16 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.98151367779853e-05 8.92308216299782e-05 1.3530381723171 0.71875 16.1 16 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 3.29383468432208e-07 2.2109088470709e-06 1.35048044420308 0.717391304347826 16.1 16 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 6.21105723345722e-14 1.578274007716e-12 1.35006707400284 0.717171717171717 16.1 16 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 7.57805394342754e-10 8.53642570136444e-09 1.34864804197214 0.716417910447761 16.1 16 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 7.57805394342754e-10 8.53642570136444e-09 1.34864804197214 0.716417910447761 16.1 16 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 3.99206769614023e-10 4.93974985357178e-09 1.34463420851389 0.714285714285714 16.1 16 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.721886810587e-07 1.18943928711908e-06 1.34463420851389 0.714285714285714 16.1 16 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.02458532781394e-05 4.79600303118168e-05 1.34463420851389 0.714285714285714 16.1 16 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 8.09243071051514e-05 0.000328077746469033 1.34463420851389 0.714285714285714 16.1 16 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000657102911796094 0.00211073915008091 1.34463420851389 0.714285714285714 16.1 16 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00560600999509391 0.0134980579069689 1.34463420851389 0.714285714285714 16.1 16 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00560600999509391 0.0134980579069689 1.34463420851389 0.714285714285714 16.1 16 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00560600999509391 0.0134980579069689 1.34463420851389 0.714285714285714 16.1 16 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00560600999509391 0.0134980579069689 1.34463420851389 0.714285714285714 16.1 16 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00560600999509391 0.0134980579069689 1.34463420851389 0.714285714285714 16.1 16 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00560600999509391 0.0134980579069689 1.34463420851389 0.714285714285714 16.1 16 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00560600999509391 0.0134980579069689 1.34463420851389 0.714285714285714 16.1 16 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0535666990619615 0.0945724724133638 1.34463420851389 0.714285714285714 16.1 16 1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0535666990619615 0.0945724724133638 1.34463420851389 0.714285714285714 16.1 16 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0535666990619615 0.0945724724133638 1.34463420851389 0.714285714285714 16.1 16 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0535666990619615 0.0945724724133638 1.34463420851389 0.714285714285714 16.1 16 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 6.87033379289354e-07 4.36450222646764e-06 1.33865805647605 0.711111111111111 16.1 16 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 5.30048833365363e-06 2.56550846897589e-05 1.33755718636382 0.710526315789474 16.1 16 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.90763727649706e-14 6.03237298767849e-13 1.33709420360634 0.710280373831776 16.1 16 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 8.27847327328386e-10 8.53642570136444e-09 1.33683922759497 0.710144927536232 16.1 16 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 4.15018820036786e-05 0.000175765410985817 1.33595914910413 0.709677419354839 16.1 16 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000332298627622324 0.00115613923497938 1.33342892344294 0.708333333333333 16.1 16 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000332298627622324 0.00115613923497938 1.33342892344294 0.708333333333333 16.1 16 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.74369686320078e-06 1.48451735221852e-05 1.33151582599181 0.707317073170732 16.1 16 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 2.13181479358043e-05 9.45038146811511e-05 1.32881498253138 0.705882352941177 16.1 16 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 2.13181479358043e-05 9.45038146811511e-05 1.32881498253138 0.705882352941177 16.1 16 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00276188336857518 0.00726462113397872 1.32881498253138 0.705882352941177 16.1 16 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00276188336857518 0.00726462113397872 1.32881498253138 0.705882352941177 16.1 16 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00276188336857518 0.00726462113397872 1.32881498253138 0.705882352941177 16.1 16 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.24840237803324e-14 1.20909531678826e-12 1.32471370172109 0.703703703703704 16.1 16 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 9.68758672067052e-08 6.85842582264385e-07 1.32471370172109 0.703703703703704 16.1 16 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000168682728483991 0.000635014610139469 1.32471370172109 0.703703703703704 16.1 16 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000168682728483991 0.000635014610139469 1.32471370172109 0.703703703703704 16.1 16 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000168682728483991 0.000635014610139469 1.32471370172109 0.703703703703704 16.1 16 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000168682728483991 0.000635014610139469 1.32471370172109 0.703703703703704 16.1 16 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.09666789916068e-05 5.05035087542283e-05 1.32282932945691 0.702702702702703 16.1 16 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.09666789916068e-05 5.05035087542283e-05 1.32282932945691 0.702702702702703 16.1 16 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 7.36507987023273e-07 4.61696416534854e-06 1.32174681773068 0.702127659574468 16.1 16 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 7.36507987023273e-07 4.61696416534854e-06 1.32174681773068 0.702127659574468 16.1 16 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.36507987023273e-07 4.61696416534854e-06 1.32174681773068 0.702127659574468 16.1 16 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.49959170462387e-09 3.45049410906133e-08 1.32055120776439 0.701492537313433 16.1 16 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00137375722841548 0.00398950313476578 1.31774152434361 0.7 16.1 16 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0247268970537246 0.0488699645936807 1.31774152434361 0.7 16.1 16 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0247268970537246 0.0488699645936807 1.31774152434361 0.7 16.1 16 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0247268970537246 0.0488699645936807 1.31774152434361 0.7 16.1 16 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0247268970537246 0.0488699645936807 1.31774152434361 0.7 16.1 16 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0247268970537246 0.0488699645936807 1.31774152434361 0.7 16.1 16 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0247268970537246 0.0488699645936807 1.31774152434361 0.7 16.1 16 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0247268970537246 0.0488699645936807 1.31774152434361 0.7 16.1 16 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 5.98350138012853e-27 7.09543538660241e-25 1.31689735936966 0.699551569506726 16.1 16 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.91372840217584e-06 1.57054375617281e-05 1.3133636455252 0.697674418604651 16.1 16 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.30268939856701e-12 2.61088311853641e-11 1.31203701558022 0.696969696969697 16.1 16 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 4.38684068043014e-05 0.000184688588409825 1.31203701558022 0.696969696969697 16.1 16 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.50451888981997e-06 8.81041308729966e-06 1.30955679437875 0.695652173913043 16.1 16 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000688288077493288 0.00219112736973814 1.30955679437875 0.695652173913043 16.1 16 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000688288077493288 0.00219112736973814 1.30955679437875 0.695652173913043 16.1 16 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 5.34444457503076e-08 3.94048944573511e-07 1.30816955201182 0.694915254237288 16.1 16 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 5.34444457503076e-08 3.94048944573511e-07 1.30816955201182 0.694915254237288 16.1 16 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.67241609823594e-15 1.41239138048371e-13 1.30559644116994 0.693548387096774 16.1 16 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.67241609823594e-15 1.41239138048371e-13 1.30559644116994 0.693548387096774 16.1 16 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.67241609823594e-15 1.41239138048371e-13 1.30559644116994 0.693548387096774 16.1 16 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.71842407201449e-11 5.68958866072755e-10 1.30490637962598 0.693181818181818 16.1 16 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000346824216773692 0.00120373380602186 1.30326084825193 0.692307692307692 16.1 16 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0117842167203954 0.0257983698355733 1.30326084825193 0.692307692307692 16.1 16 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0117842167203954 0.0257983698355733 1.30326084825193 0.692307692307692 16.1 16 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0117842167203954 0.0257983698355733 1.30326084825193 0.692307692307692 16.1 16 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0117842167203954 0.0257983698355733 1.30326084825193 0.692307692307692 16.1 16 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0117842167203954 0.0257983698355733 1.30326084825193 0.692307692307692 16.1 16 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0117842167203954 0.0257983698355733 1.30326084825193 0.692307692307692 16.1 16 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 5.91907317944833e-06 2.84555443728209e-05 1.2998130682301 0.69047619047619 16.1 16 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.48402497345541e-11 1.0757340946694e-09 1.29826751166859 0.689655172413793 16.1 16 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.57090339652177e-33 8.13049441656309e-31 1.29782441695471 0.689419795221843 16.1 16 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.90620078077793e-11 5.91332309685851e-10 1.29682499221118 0.688888888888889 16.1 16 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 5.59895620915747e-08 4.0454300928985e-07 1.29613920427241 0.688524590163934 16.1 16 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.59895620915747e-08 4.0454300928985e-07 1.29613920427241 0.688524590163934 16.1 16 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00572702552827093 0.0135825955445492 1.29421042569462 0.6875 16.1 16 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00572702552827093 0.0135825955445492 1.29421042569462 0.6875 16.1 16 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00572702552827093 0.0135825955445492 1.29421042569462 0.6875 16.1 16 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00572702552827093 0.0135825955445492 1.29421042569462 0.6875 16.1 16 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00572702552827093 0.0135825955445492 1.29421042569462 0.6875 16.1 16 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00572702552827093 0.0135825955445492 1.29421042569462 0.6875 16.1 16 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00572702552827093 0.0135825955445492 1.29421042569462 0.6875 16.1 16 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.57023936112737e-06 9.0831325645701e-06 1.29421042569462 0.6875 16.1 16 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.49881704254451e-10 2.05078524186619e-09 1.29147425143311 0.686046511627907 16.1 16 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 5.02653661288992e-29 6.50251054558396e-27 1.29105491438154 0.685823754789272 16.1 16 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 4.07381008060284e-09 3.97056968814921e-08 1.28937526843798 0.684931506849315 16.1 16 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00282052599036382 0.00736441923722517 1.28801803131331 0.684210526315789 16.1 16 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00282052599036382 0.00736441923722517 1.28801803131331 0.684210526315789 16.1 16 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.12521620571139e-11 3.6880276350333e-10 1.28801803131331 0.684210526315789 16.1 16 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 5.80657291672485e-08 4.17310770732296e-07 1.2848726881355 0.682539682539683 16.1 16 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.98634627410188e-10 3.82844211535763e-09 1.28452114978033 0.682352941176471 16.1 16 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00140254769472335 0.00399965003926117 1.28351447176326 0.681818181818182 16.1 16 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00140254769472335 0.00399965003926117 1.28351447176326 0.681818181818182 16.1 16 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00140254769472335 0.00399965003926117 1.28351447176326 0.681818181818182 16.1 16 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00140254769472335 0.00399965003926117 1.28351447176326 0.681818181818182 16.1 16 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00140254769472335 0.00399965003926117 1.28351447176326 0.681818181818182 16.1 16 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00140254769472335 0.00399965003926117 1.28351447176326 0.681818181818182 16.1 16 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00140254769472335 0.00399965003926117 1.28351447176326 0.681818181818182 16.1 16 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.5618307529136e-08 1.26277565988412e-07 1.28227436116252 0.681159420289855 16.1 16 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.10786403790163e-09 6.66906966816996e-08 1.28113759311185 0.680555555555556 16.1 16 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 4.30956876895043e-07 2.81308089826443e-06 1.2774024980882 0.678571428571429 16.1 16 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000353950506950428 0.00121954375639336 1.2774024980882 0.678571428571429 16.1 16 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000353950506950428 0.00121954375639336 1.2774024980882 0.678571428571429 16.1 16 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000353950506950428 0.00121954375639336 1.2774024980882 0.678571428571429 16.1 16 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 5.91900166692869e-10 7.0189494766996e-09 1.2774024980882 0.678571428571429 16.1 16 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 5.91900166692869e-10 7.0189494766996e-09 1.2774024980882 0.678571428571429 16.1 16 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.40230458864553e-44 3.32579904940432e-42 1.27708685625521 0.678403755868545 16.1 16 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 9.10189480747948e-05 0.000362801017116059 1.27344769159257 0.676470588235294 16.1 16 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 9.10189480747948e-05 0.000362801017116059 1.27344769159257 0.676470588235294 16.1 16 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 6.23330600675236e-06 2.97650820389551e-05 1.26863314455441 0.673913043478261 16.1 16 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 3.20491989802646e-06 1.66221438294309e-05 1.26779796802738 0.673469387755102 16.1 16 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.20897513252067e-11 2.12391557231718e-10 1.26705915802271 0.673076923076923 16.1 16 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 6.30127597939536e-12 1.18483868948784e-10 1.26672082446916 0.672897196261682 16.1 16 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 8.51011607993445e-07 5.21978240592531e-06 1.26640094547308 0.672727272727273 16.1 16 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.43213348835011e-18 4.23037038156888e-16 1.26237423340481 0.670588235294118 16.1 16 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 4.53689150356421e-11 6.68836534669717e-10 1.26126688758603 0.67 16.1 16 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.44761944737948e-17 7.92293259084998e-16 1.25870492181596 0.668639053254438 16.1 16 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.18952219622875e-08 2.43875111780479e-07 1.2549919279463 0.666666666666667 16.1 16 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.29591358836329e-07 1.56147447749425e-06 1.2549919279463 0.666666666666667 16.1 16 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 9.15164111175824e-05 0.000363764952570726 1.2549919279463 0.666666666666667 16.1 16 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00567519726508105 0.0135825955445492 1.2549919279463 0.666666666666667 16.1 16 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00567519726508105 0.0135825955445492 1.2549919279463 0.666666666666667 16.1 16 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0513609983487038 0.0927496201144739 1.2549919279463 0.666666666666667 16.1 16 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0513609983487038 0.0927496201144739 1.2549919279463 0.666666666666667 16.1 16 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0513609983487038 0.0927496201144739 1.2549919279463 0.666666666666667 16.1 16 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0513609983487038 0.0927496201144739 1.2549919279463 0.666666666666667 16.1 16 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0513609983487038 0.0927496201144739 1.2549919279463 0.666666666666667 16.1 16 1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0513609983487038 0.0927496201144739 1.2549919279463 0.666666666666667 16.1 16 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.65434108425071e-08 1.33001545925919e-07 1.2549919279463 0.666666666666667 16.1 16 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 4.44076199812307e-07 2.88548142617768e-06 1.2549919279463 0.666666666666667 16.1 16 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.66672617597987e-06 9.48700539367741e-06 1.2549919279463 0.666666666666667 16.1 16 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.22436612140978e-05 5.60216395744734e-05 1.2549919279463 0.666666666666667 16.1 16 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 2.38841142477611e-05 0.000104898440044951 1.2549919279463 0.666666666666667 16.1 16 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000179901350892009 0.000673683216629813 1.2549919279463 0.666666666666667 16.1 16 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000703107193353095 0.0022283330426313 1.2549919279463 0.666666666666667 16.1 16 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000703107193353095 0.0022283330426313 1.2549919279463 0.666666666666667 16.1 16 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00140026697723522 0.00399965003926117 1.2549919279463 0.666666666666667 16.1 16 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00280706586165426 0.0073562702046667 1.2549919279463 0.666666666666667 16.1 16 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00280706586165426 0.0073562702046667 1.2549919279463 0.666666666666667 16.1 16 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0116053019753572 0.0256433924082815 1.2549919279463 0.666666666666667 16.1 16 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0241169102665702 0.0482507329644206 1.2549919279463 0.666666666666667 16.1 16 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0241169102665702 0.0482507329644206 1.2549919279463 0.666666666666667 16.1 16 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0241169102665702 0.0482507329644206 1.2549919279463 0.666666666666667 16.1 16 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0241169102665702 0.0482507329644206 1.2549919279463 0.666666666666667 16.1 16 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0241169102665702 0.0482507329644206 1.2549919279463 0.666666666666667 16.1 16 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0241169102665702 0.0482507329644206 1.2549919279463 0.666666666666667 16.1 16 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0241169102665702 0.0482507329644206 1.2549919279463 0.666666666666667 16.1 16 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.03356383773496e-50 3.67690335274211e-48 1.25260601173347 0.665399239543726 16.1 16 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.70999182597558e-10 2.30393030233579e-09 1.24858890790576 0.663265306122449 16.1 16 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.28462992907376e-10 4.13630830891324e-09 1.2483867072729 0.663157894736842 16.1 16 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.28462992907376e-10 4.13630830891324e-09 1.2483867072729 0.663157894736842 16.1 16 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.01188255633681e-16 1.02246745630974e-14 1.24729259096503 0.662576687116564 16.1 16 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.63279679636398e-14 1.05499384514815e-12 1.24596320904021 0.661870503597122 16.1 16 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.30435446432743e-07 1.56147447749425e-06 1.24533814388517 0.661538461538462 16.1 16 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 4.0195902495723e-50 1.14397538502828e-47 1.24441615327259 0.661048689138577 16.1 16 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 8.61734836836786e-07 5.26286984042381e-06 1.2443564031332 0.661016949152542 16.1 16 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.2364240577877e-06 1.6626106260765e-05 1.24315238145624 0.660377358490566 16.1 16 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 3.2364240577877e-06 1.6626106260765e-05 1.24315238145624 0.660377358490566 16.1 16 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.71620950138857e-10 2.30393030233579e-09 1.24244200866684 0.66 16.1 16 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 6.2842677216237e-06 2.99080701266573e-05 1.24244200866684 0.66 16.1 16 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.3806683591705e-05 0.000104882076628471 1.24073065603782 0.659090909090909 16.1 16 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.90578337526821e-13 1.04192981238905e-11 1.24039899855158 0.65891472868217 16.1 16 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 4.64676590324948e-05 0.000195054509744071 1.2396871483372 0.658536585365854 16.1 16 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.20482402691142e-08 2.43875111780479e-07 1.2384788762628 0.657894736842105 16.1 16 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 9.09052877878055e-05 0.000362801017116059 1.2384788762628 0.657894736842105 16.1 16 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 9.09052877878055e-05 0.000362801017116059 1.2384788762628 0.657894736842105 16.1 16 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.14167220913456e-18 2.45566648066603e-16 1.23821396099515 0.657754010695187 16.1 16 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.43020068294508e-11 4.16647659256728e-10 1.23803257756865 0.657657657657658 16.1 16 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 6.5979677693615e-12 1.21933871893525e-10 1.23389962663628 0.65546218487395 16.1 16 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.6587197630146e-06 9.47935029224811e-06 1.23335413608516 0.655172413793103 16.1 16 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.21229062058572e-06 1.66221438294309e-05 1.23217389289273 0.654545454545455 16.1 16 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.21229062058572e-06 1.66221438294309e-05 1.23217389289273 0.654545454545455 16.1 16 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.21229062058572e-06 1.66221438294309e-05 1.23217389289273 0.654545454545455 16.1 16 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.21229062058572e-06 1.66221438294309e-05 1.23217389289273 0.654545454545455 16.1 16 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.21229062058572e-06 1.66221438294309e-05 1.23217389289273 0.654545454545455 16.1 16 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 3.21229062058572e-06 1.66221438294309e-05 1.23217389289273 0.654545454545455 16.1 16 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.88448934229296e-13 1.04192981238905e-11 1.23140185411272 0.654135338345865 16.1 16 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 1.20924471643089e-05 5.55082332735855e-05 1.22937984778413 0.653061224489796 16.1 16 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 8.82992180979521e-11 1.23186066032731e-09 1.22620770941542 0.651376146788991 16.1 16 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 8.47595777391815e-07 5.21978240592531e-06 1.2251111677571 0.650793650793651 16.1 16 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.63738659131082e-06 9.39516580417458e-06 1.22361712974764 0.65 16.1 16 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 8.93792694665475e-05 0.000360302267566281 1.22361712974764 0.65 16.1 16 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00550738226255358 0.0134195290404345 1.22361712974764 0.65 16.1 16 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00550738226255358 0.0134195290404345 1.22361712974764 0.65 16.1 16 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00550738226255358 0.0134195290404345 1.22361712974764 0.65 16.1 16 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00550738226255358 0.0134195290404345 1.22361712974764 0.65 16.1 16 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00550738226255358 0.0134195290404345 1.22361712974764 0.65 16.1 16 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00550738226255358 0.0134195290404345 1.22361712974764 0.65 16.1 16 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 4.55918087582309e-11 6.68836534669717e-10 1.22196582457929 0.649122807017544 16.1 16 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00017482503844377 0.00065640113378756 1.22107322719099 0.648648648648649 16.1 16 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 6.1279727874338e-06 2.93606238266609e-05 1.2201310410589 0.648148148148148 16.1 16 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.24379232283619e-07 1.53505599778649e-06 1.21964004265204 0.647887323943662 16.1 16 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 9.62810325094162e-15 3.42519773152248e-13 1.21947328847612 0.647798742138365 16.1 16 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0111631194877131 0.0250553927934003 1.21808040065376 0.647058823529412 16.1 16 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0111631194877131 0.0250553927934003 1.21808040065376 0.647058823529412 16.1 16 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0111631194877131 0.0250553927934003 1.21808040065376 0.647058823529412 16.1 16 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.10091120232458e-08 2.3981503483195e-07 1.21672997892355 0.646341463414634 16.1 16 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 6.32802111040587e-12 1.18483868948784e-10 1.21546462312909 0.645669291338583 16.1 16 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.81192162669309e-14 5.85991926087332e-13 1.21527699351762 0.645569620253165 16.1 16 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 5.95624348458028e-08 4.23786723927887e-07 1.21527699351762 0.645569620253165 16.1 16 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.60654755968075e-06 9.25553513127815e-06 1.21450831736739 0.645161290322581 16.1 16 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000674443395061014 0.00215670326106028 1.21450831736739 0.645161290322581 16.1 16 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000674443395061014 0.00215670326106028 1.21450831736739 0.645161290322581 16.1 16 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.39824199951766e-14 1.00743715944034e-12 1.21102724257238 0.643312101910828 16.1 16 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0013315892288779 0.00387495188689826 1.2101707876625 0.642857142857143 16.1 16 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0229049888259382 0.0468301711196983 1.2101707876625 0.642857142857143 16.1 16 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0229049888259382 0.0468301711196983 1.2101707876625 0.642857142857143 16.1 16 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0229049888259382 0.0468301711196983 1.2101707876625 0.642857142857143 16.1 16 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0229049888259382 0.0468301711196983 1.2101707876625 0.642857142857143 16.1 16 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0229049888259382 0.0468301711196983 1.2101707876625 0.642857142857143 16.1 16 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.96568566833593e-18 1.27144123001911e-16 1.2101707876625 0.642857142857143 16.1 16 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.35129649304805e-14 1.58559559817673e-12 1.20672300764067 0.641025641025641 16.1 16 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 5.19744943141146e-19 3.5218907337612e-17 1.20650360345747 0.640909090909091 16.1 16 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.56768797481711e-06 9.0831325645701e-06 1.2059688057609 0.640625 16.1 16 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.56768797481711e-06 9.0831325645701e-06 1.2059688057609 0.640625 16.1 16 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 2.24180995068602e-05 9.90712906778327e-05 1.20479225082845 0.64 16.1 16 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00264063643191247 0.00698443427994692 1.20479225082845 0.64 16.1 16 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.96699105569201e-08 2.30711927445341e-07 1.20391667506476 0.63953488372093 16.1 16 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 4.23123582795377e-11 6.33794587702969e-10 1.20355783253866 0.639344262295082 16.1 16 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.02005168485569e-06 1.61561411562017e-05 1.20355783253866 0.639344262295082 16.1 16 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00033186740403686 0.00115613923497938 1.2027005976152 0.638888888888889 16.1 16 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00033186740403686 0.00115613923497938 1.2027005976152 0.638888888888889 16.1 16 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 7.92127302867881e-07 4.90085718252606e-06 1.20042706151385 0.63768115942029 16.1 16 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 7.92127302867881e-07 4.90085718252606e-06 1.20042706151385 0.63768115942029 16.1 16 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 5.60771092085409e-10 6.82031849604733e-09 1.19794684031238 0.636363636363636 16.1 16 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000649987729462262 0.00209260755435475 1.19794684031238 0.636363636363636 16.1 16 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.000649987729462262 0.00209260755435475 1.19794684031238 0.636363636363636 16.1 16 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000649987729462262 0.00209260755435475 1.19794684031238 0.636363636363636 16.1 16 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.000649987729462262 0.00209260755435475 1.19794684031238 0.636363636363636 16.1 16 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0478218529371976 0.0876939390845775 1.19794684031238 0.636363636363636 16.1 16 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0478218529371976 0.0876939390845775 1.19794684031238 0.636363636363636 16.1 16 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0478218529371976 0.0876939390845775 1.19794684031238 0.636363636363636 16.1 16 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0478218529371976 0.0876939390845775 1.19794684031238 0.636363636363636 16.1 16 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0478218529371976 0.0876939390845775 1.19794684031238 0.636363636363636 16.1 16 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0478218529371976 0.0876939390845775 1.19794684031238 0.636363636363636 16.1 16 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0478218529371976 0.0876939390845775 1.19794684031238 0.636363636363636 16.1 16 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0478218529371976 0.0876939390845775 1.19794684031238 0.636363636363636 16.1 16 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.00123210221453e-07 2.62384943845681e-06 1.19563420162452 0.635135135135135 16.1 16 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.00123210221453e-07 2.62384943845681e-06 1.19563420162452 0.635135135135135 16.1 16 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 7.63569731001525e-11 1.08655972721517e-09 1.19377280950989 0.634146341463415 16.1 16 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000163759394218906 0.000624744284111269 1.19377280950989 0.634146341463415 16.1 16 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000163759394218906 0.000624744284111269 1.19377280950989 0.634146341463415 16.1 16 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000163759394218906 0.000624744284111269 1.19377280950989 0.634146341463415 16.1 16 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000163759394218906 0.000624744284111269 1.19377280950989 0.634146341463415 16.1 16 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000163759394218906 0.000624744284111269 1.19377280950989 0.634146341463415 16.1 16 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000163759394218906 0.000624744284111269 1.19377280950989 0.634146341463415 16.1 16 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000163759394218906 0.000624744284111269 1.19377280950989 0.634146341463415 16.1 16 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 5.44368605913818e-10 6.67790108806348e-09 1.19336286005608 0.633928571428571 16.1 16 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 5.47366347538749e-12 1.05257069263195e-10 1.19179089560368 0.633093525179856 16.1 16 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.27177323306819e-68 1.80973331065604e-65 1.19039675518436 0.632352941176471 16.1 16 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.23673233229759e-22 5.91658007257298e-20 1.19039675518436 0.632352941176471 16.1 16 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 5.34269232652969e-08 3.94048944573511e-07 1.19007855236287 0.632183908045977 16.1 16 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 5.34269232652969e-08 3.94048944573511e-07 1.19007855236287 0.632183908045977 16.1 16 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 7.47732756583400e-13 1.56474075385026e-11 1.18893972121228 0.631578947368421 16.1 16 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 3.86701910356567e-07 2.55942706249951e-06 1.18893972121228 0.631578947368421 16.1 16 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0105689194503106 0.023906045365627 1.18893972121228 0.631578947368421 16.1 16 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0105689194503106 0.023906045365627 1.18893972121228 0.631578947368421 16.1 16 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0105689194503106 0.023906045365627 1.18893972121228 0.631578947368421 16.1 16 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 7.4007797190111e-07 4.61899541234772e-06 1.18622524696294 0.63013698630137 16.1 16 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 7.1751087847594e-09 6.66906966816996e-08 1.18596737190925 0.63 16.1 16 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00251587570579218 0.00675488892328731 1.18527015417151 0.62962962962963 16.1 16 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00251587570579218 0.00675488892328731 1.18527015417151 0.62962962962963 16.1 16 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 1.41653254838734e-06 8.32944552212888e-06 1.18327810349223 0.628571428571429 16.1 16 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000621309126178752 0.00202316450011983 1.18327810349223 0.628571428571429 16.1 16 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000621309126178752 0.00202316450011983 1.18327810349223 0.628571428571429 16.1 16 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000621309126178752 0.00202316450011983 1.18327810349223 0.628571428571429 16.1 16 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 7.1099400635891e-15 2.59421659243264e-13 1.18298419437561 0.628415300546448 16.1 16 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 7.1099400635891e-15 2.59421659243264e-13 1.18298419437561 0.628415300546448 16.1 16 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 3.72369547797348e-07 2.47608348839077e-06 1.18258854748786 0.628205128205128 16.1 16 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.8716052359418e-13 4.22745119165902e-12 1.18229422480307 0.628048780487805 16.1 16 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.55385413917229e-14 7.73220093625994e-13 1.18054325425457 0.627118644067797 16.1 16 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.35859518904897e-06 8.05533730840284e-06 1.17655493244966 0.625 16.1 16 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.99641267617257e-05 8.92431533366386e-05 1.17655493244966 0.625 16.1 16 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00121377929984557 0.00366710816067994 1.17655493244966 0.625 16.1 16 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00121377929984557 0.00366710816067994 1.17655493244966 0.625 16.1 16 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0214024293871677 0.0441860110185453 1.17655493244966 0.625 16.1 16 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0214024293871677 0.0441860110185453 1.17655493244966 0.625 16.1 16 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.102550817311597 0.169095959483665 1.17655493244966 0.625 16.1 16 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000303982143028274 0.00107925407538442 1.17655493244966 0.625 16.1 16 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0049776469766872 0.0124296402704027 1.17655493244966 0.625 16.1 16 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0049776469766872 0.0124296402704027 1.17655493244966 0.625 16.1 16 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.59489376944316e-06 1.41476392104123e-05 1.17314462829763 0.623188405797101 16.1 16 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 8.36273884313375e-20 5.95008868688966e-18 1.17293476342673 0.623076923076923 16.1 16 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.09564454850921e-11 5.18247316768071e-10 1.16983176140709 0.621428571428571 16.1 16 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.09564454850921e-11 5.18247316768071e-10 1.16983176140709 0.621428571428571 16.1 16 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.15709101089683e-10 1.59858301796717e-09 1.16942429649542 0.621212121212121 16.1 16 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.90296902355055e-05 8.59658704924582e-05 1.16844076050173 0.620689655172414 16.1 16 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00237675564955373 0.00642989218500942 1.16844076050173 0.620689655172414 16.1 16 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 4.01460007853573e-12 7.93441098855048e-11 1.16592798467269 0.619354838709677 16.1 16 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00989539641401498 0.0227850309015264 1.16534964737871 0.619047619047619 16.1 16 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00989539641401498 0.0227850309015264 1.16534964737871 0.619047619047619 16.1 16 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00989539641401498 0.0227850309015264 1.16534964737871 0.619047619047619 16.1 16 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 4.71488321899821e-06 2.30559409643796e-05 1.16271310971495 0.617647058823529 16.1 16 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00114612937880939 0.00348491903001231 1.16271310971495 0.617647058823529 16.1 16 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00114612937880939 0.00348491903001231 1.16271310971495 0.617647058823529 16.1 16 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00466645002105097 0.0117528466901868 1.15845408733505 0.615384615384615 16.1 16 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00466645002105097 0.0117528466901868 1.15845408733505 0.615384615384615 16.1 16 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0438492199404498 0.0813525944918646 1.15845408733505 0.615384615384615 16.1 16 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0438492199404498 0.0813525944918646 1.15845408733505 0.615384615384615 16.1 16 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0438492199404498 0.0813525944918646 1.15845408733505 0.615384615384615 16.1 16 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.70983983309241e-05 7.74873274678501e-05 1.15378290149902 0.612903225806452 16.1 16 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 8.49483070236342e-06 4.00269671836528e-05 1.15197020251787 0.611940298507463 16.1 16 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 4.22856782861648e-06 2.15672115416532e-05 1.15040926728411 0.611111111111111 16.1 16 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 4.22856782861648e-06 2.15672115416532e-05 1.15040926728411 0.611111111111111 16.1 16 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.019786997266135 0.041225325197233 1.15040926728411 0.611111111111111 16.1 16 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.019786997266135 0.041225325197233 1.15040926728411 0.611111111111111 16.1 16 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.019786997266135 0.041225325197233 1.15040926728411 0.611111111111111 16.1 16 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.019786997266135 0.041225325197233 1.15040926728411 0.611111111111111 16.1 16 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.019786997266135 0.041225325197233 1.15040926728411 0.611111111111111 16.1 16 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.019786997266135 0.041225325197233 1.15040926728411 0.611111111111111 16.1 16 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.019786997266135 0.041225325197233 1.15040926728411 0.611111111111111 16.1 16 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 6.37177909485907e-10 7.43200135408562e-09 1.14961092636302 0.610687022900763 16.1 16 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 6.37177909485907e-10 7.43200135408562e-09 1.14961092636302 0.610687022900763 16.1 16 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.05283379755594e-06 6.3752446549877e-06 1.14785847068259 0.609756097560976 16.1 16 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.76745704913074e-08 1.4129726859062e-07 1.14660626144185 0.609090909090909 16.1 16 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 3.6334518985518e-13 7.95446469482956e-12 1.1458621950814 0.608695652173913 16.1 16 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.000255703731501718 0.000918854570522588 1.1458621950814 0.608695652173913 16.1 16 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 4.96393967856652e-07 3.19623808262451e-06 1.14218366476012 0.606741573033708 16.1 16 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.12200672270457e-09 2.11161927720881e-08 1.14135092659683 0.606299212598425 16.1 16 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.13288810485154e-08 2.40978366119121e-07 1.13985505382279 0.605504587155963 16.1 16 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 1.8711147076494e-06 1.04826623188389e-05 1.13878897165498 0.604938271604938 16.1 16 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.8711147076494e-06 1.04826623188389e-05 1.13878897165498 0.604938271604938 16.1 16 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000489352424512894 0.00163846705901611 1.1382484927885 0.604651162790698 16.1 16 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.08805815696954e-63 7.74153378683829e-61 1.13816084756691 0.604604604604605 16.1 16 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000239417731575648 0.00086469906607144 1.13733643470133 0.604166666666667 16.1 16 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 7.44296124014461e-09 6.66906966816996e-08 1.13571583562082 0.603305785123967 16.1 16 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 7.44296124014461e-09 6.66906966816996e-08 1.13571583562082 0.603305785123967 16.1 16 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.7569979667309e-06 9.92146074070661e-06 1.13402885055389 0.602409638554217 16.1 16 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.39096351589875e-11 7.82789906441216e-10 1.12949273515167 0.6 16.1 16 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 2.06062112105835e-07 1.41655258708504e-06 1.12949273515167 0.6 16.1 16 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000223445477215227 0.000815289523275046 1.12949273515167 0.6 16.1 16 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00193335975775535 0.00532141380132661 1.12949273515167 0.6 16.1 16 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00402690265098935 0.0102877602735329 1.12949273515167 0.6 16.1 16 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0084831627938493 0.0198591555990982 1.12949273515167 0.6 16.1 16 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0084831627938493 0.0198591555990982 1.12949273515167 0.6 16.1 16 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0181612252319461 0.0384574754539572 1.12949273515167 0.6 16.1 16 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0181612252319461 0.0384574754539572 1.12949273515167 0.6 16.1 16 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0181612252319461 0.0384574754539572 1.12949273515167 0.6 16.1 16 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0181612252319461 0.0384574754539572 1.12949273515167 0.6 16.1 16 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0398545191018096 0.0764325885200472 1.12949273515167 0.6 16.1 16 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0398545191018096 0.0764325885200472 1.12949273515167 0.6 16.1 16 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0398545191018096 0.0764325885200472 1.12949273515167 0.6 16.1 16 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0398545191018096 0.0764325885200472 1.12949273515167 0.6 16.1 16 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0398545191018096 0.0764325885200472 1.12949273515167 0.6 16.1 16 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0913121502911727 0.153954016426942 1.12949273515167 0.6 16.1 16 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.40103226006786e-20 1.17274641533916e-18 1.1260280335101 0.598159509202454 16.1 16 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 4.70803066109411e-05 0.000197044930315792 1.11772718582717 0.59375 16.1 16 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.2681981520841e-22 1.38818920801206e-20 1.11741259894684 0.593582887700535 16.1 16 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.66391228623655e-29 3.7907471833146e-27 1.11724891146439 0.59349593495935 16.1 16 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.68455851350706e-06 1.4580636506567e-05 1.11635909869642 0.593023255813954 16.1 16 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 5.37935027854744e-06 2.59485269368577e-05 1.11554838039671 0.592592592592593 16.1 16 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00779455811597282 0.0183636692036909 1.11554838039671 0.592592592592593 16.1 16 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 2.49796359889186e-06 1.37243328232553e-05 1.11237920886149 0.590909090909091 16.1 16 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000803174855241601 0.00248460395436695 1.11237920886149 0.590909090909091 16.1 16 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0165837862899051 0.035380401634985 1.11237920886149 0.590909090909091 16.1 16 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0016508984061861 0.00468907870659246 1.11018516702942 0.58974358974359 16.1 16 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 4.64365788210477e-06 2.28647929627512e-05 1.10734581877615 0.588235294117647 16.1 16 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 4.64365788210477e-06 2.28647929627512e-05 1.10734581877615 0.588235294117647 16.1 16 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 4.64365788210477e-06 2.28647929627512e-05 1.10734581877615 0.588235294117647 16.1 16 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 4.64365788210477e-06 2.28647929627512e-05 1.10734581877615 0.588235294117647 16.1 16 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 4.64365788210477e-06 2.28647929627512e-05 1.10734581877615 0.588235294117647 16.1 16 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 4.64365788210477e-06 2.28647929627512e-05 1.10734581877615 0.588235294117647 16.1 16 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 4.64365788210477e-06 2.28647929627512e-05 1.10734581877615 0.588235294117647 16.1 16 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.000363266767855878 0.00124861983250946 1.10734581877615 0.588235294117647 16.1 16 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00341689604341729 0.00876079832393297 1.10734581877615 0.588235294117647 16.1 16 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00341689604341729 0.00876079832393297 1.10734581877615 0.588235294117647 16.1 16 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00341689604341729 0.00876079832393297 1.10734581877615 0.588235294117647 16.1 16 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0360300149578168 0.0698511052928792 1.10734581877615 0.588235294117647 16.1 16 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0360300149578168 0.0698511052928792 1.10734581877615 0.588235294117647 16.1 16 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.7324670999155e-13 3.97629142448348e-12 1.10585611588093 0.587443946188341 16.1 16 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000741037078204045 0.00234332391618746 1.10493854525707 0.58695652173913 16.1 16 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 3.75138724748105e-05 0.000159349971736285 1.10260005098139 0.585714285714286 16.1 16 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.46666512845592e-05 0.000147696541251281 1.09811793695301 0.583333333333333 16.1 16 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00313345885325042 0.00816650539958854 1.09811793695301 0.583333333333333 16.1 16 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0810087726760759 0.138385934595505 1.09811793695301 0.583333333333333 16.1 16 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0810087726760759 0.138385934595505 1.09811793695301 0.583333333333333 16.1 16 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0810087726760759 0.138385934595505 1.09811793695301 0.583333333333333 16.1 16 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0810087726760759 0.138385934595505 1.09811793695301 0.583333333333333 16.1 16 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0810087726760759 0.138385934595505 1.09811793695301 0.583333333333333 16.1 16 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0810087726760759 0.138385934595505 1.09811793695301 0.583333333333333 16.1 16 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00139471837951284 0.00399965003926117 1.09446970460433 0.581395348837209 16.1 16 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00651469525232033 0.0153993543921127 1.09305748563065 0.580645161290323 16.1 16 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00651469525232033 0.0153993543921127 1.09305748563065 0.580645161290323 16.1 16 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 9.51093163316684e-09 7.7781929390784e-08 1.09263283237283 0.58041958041958 16.1 16 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.000626878730976853 0.00203664026068507 1.09184297731328 0.58 16.1 16 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.94848811229894e-05 0.000127084315456658 1.08986141111126 0.578947368421053 16.1 16 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0324618542628936 0.0632783816658872 1.08986141111126 0.578947368421053 16.1 16 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0324618542628936 0.0632783816658872 1.08986141111126 0.578947368421053 16.1 16 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.13855587218964e-15 1.31357794297819e-13 1.08735762710149 0.577617328519856 16.1 16 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000575067299251296 0.00190750761499905 1.08605070687661 0.576923076923077 16.1 16 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0136877711203926 0.029736943976059 1.08605070687661 0.576923076923077 16.1 16 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0136877711203926 0.029736943976059 1.08605070687661 0.576923076923077 16.1 16 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0136877711203926 0.029736943976059 1.08605070687661 0.576923076923077 16.1 16 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0136877711203926 0.029736943976059 1.08605070687661 0.576923076923077 16.1 16 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000260592957934454 0.000934064934863294 1.08482353093663 0.576271186440678 16.1 16 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 8.76115460654681e-12 1.55839037563951e-10 1.08467159486787 0.576190476190476 16.1 16 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.70137304619367e-08 2.11211749710637e-07 1.08142921450692 0.574468085106383 16.1 16 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00023894199680928 0.00086469906607144 1.08011600356034 0.573770491803279 16.1 16 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0123924534377236 0.0270882661165602 1.07570736681111 0.571428571428571 16.1 16 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0717748614264653 0.123800760981649 1.07570736681111 0.571428571428571 16.1 16 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0717748614264653 0.123800760981649 1.07570736681111 0.571428571428571 16.1 16 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0717748614264653 0.123800760981649 1.07570736681111 0.571428571428571 16.1 16 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0717748614264653 0.123800760981649 1.07570736681111 0.571428571428571 16.1 16 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0717748614264653 0.123800760981649 1.07570736681111 0.571428571428571 16.1 16 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0717748614264653 0.123800760981649 1.07570736681111 0.571428571428571 16.1 16 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0717748614264653 0.123800760981649 1.07570736681111 0.571428571428571 16.1 16 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0717748614264653 0.123800760981649 1.07570736681111 0.571428571428571 16.1 16 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0010679964509735 0.00326128529986113 1.07570736681111 0.571428571428571 16.1 16 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0010679964509735 0.00326128529986113 1.07570736681111 0.571428571428571 16.1 16 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00238683210162287 0.00643600327317283 1.07570736681111 0.571428571428571 16.1 16 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0291823303225208 0.0572778704123408 1.07570736681111 0.571428571428571 16.1 16 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0291823303225208 0.0572778704123408 1.07570736681111 0.571428571428571 16.1 16 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0291823303225208 0.0572778704123408 1.07570736681111 0.571428571428571 16.1 16 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.67585241840063e-38 1.35710542734058e-35 1.07260833790545 0.569782330345711 16.1 16 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 4.19479267417502e-05 0.000177127298971841 1.07230322957437 0.569620253164557 16.1 16 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000440329643140553 0.00148480825163272 1.07107069712658 0.568965517241379 16.1 16 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000440329643140553 0.00148480825163272 1.07107069712658 0.568965517241379 16.1 16 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000440329643140553 0.00148480825163272 1.07107069712658 0.568965517241379 16.1 16 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0112019573165367 0.0251029689156406 1.06674313875435 0.566666666666667 16.1 16 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 5.3956518533931e-12 1.05178254621622e-10 1.06647382718183 0.566523605150215 16.1 16 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.48176697839852e-05 6.73659555993959e-05 1.06401489543273 0.565217391304348 16.1 16 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0019761139409745 0.00542859100001297 1.06401489543273 0.565217391304348 16.1 16 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0261957968149838 0.0517012744351205 1.06401489543273 0.565217391304348 16.1 16 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0101134700038257 0.0232495441283424 1.05889943920469 0.5625 16.1 16 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0635786344492063 0.111009075854258 1.05889943920469 0.5625 16.1 16 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0635786344492063 0.111009075854258 1.05889943920469 0.5625 16.1 16 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0635786344492063 0.111009075854258 1.05889943920469 0.5625 16.1 16 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0635786344492063 0.111009075854258 1.05889943920469 0.5625 16.1 16 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0635786344492063 0.111009075854258 1.05889943920469 0.5625 16.1 16 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 7.68736758914789e-10 8.53642570136444e-09 1.05889943920469 0.5625 16.1 16 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00179519613780644 0.00505854278039319 1.05889943920469 0.5625 16.1 16 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000304132736633276 0.00107925407538442 1.05533412122757 0.560606060606061 16.1 16 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.5069960585772e-20 1.19136410630853e-18 1.05520621744364 0.560538116591928 16.1 16 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00025165832758047 0.000906607088979768 1.04881468264084 0.557142857142857 16.1 16 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.40914823207643e-06 8.32040636616083e-06 1.04751342372937 0.556451612903226 16.1 16 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 9.55109201568749e-05 0.000378585067919869 1.04582660662192 0.555555555555556 16.1 16 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0210542873759172 0.0438015364560383 1.04582660662192 0.555555555555556 16.1 16 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0563337870724192 0.0992116076782828 1.04582660662192 0.555555555555556 16.1 16 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0563337870724192 0.0992116076782828 1.04582660662192 0.555555555555556 16.1 16 1 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.166538091015214 0.244817875531663 1.04582660662192 0.555555555555556 16.1 16 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 2.51140346354457e-06 1.37451043408612e-05 1.0423693285835 0.553719008264463 16.1 16 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00740606219919924 0.0174773242279611 1.04032225606075 0.552631578947368 16.1 16 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0188618201228482 0.0397635111626859 1.03861400933487 0.551724137931034 16.1 16 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0188618201228482 0.0397635111626859 1.03861400933487 0.551724137931034 16.1 16 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0188618201228482 0.0397635111626859 1.03861400933487 0.551724137931034 16.1 16 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.049940400856274 0.0908762025811738 1.0353683405557 0.55 16.1 16 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.00219058906950236 0.00599463124211895 1.03004054463517 0.547169811320755 16.1 16 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0151289605753246 0.0324713588215488 1.02681157741061 0.545454545454545 16.1 16 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0151289605753246 0.0324713588215488 1.02681157741061 0.545454545454545 16.1 16 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0151289605753246 0.0324713588215488 1.02681157741061 0.545454545454545 16.1 16 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.143500507115943 0.215038538942569 1.02681157741061 0.545454545454545 16.1 16 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.143500507115943 0.215038538942569 1.02681157741061 0.545454545454545 16.1 16 1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.143500507115943 0.215038538942569 1.02681157741061 0.545454545454545 16.1 16 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.143500507115943 0.215038538942569 1.02681157741061 0.545454545454545 16.1 16 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.143500507115943 0.215038538942569 1.02681157741061 0.545454545454545 16.1 16 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.143500507115943 0.215038538942569 1.02681157741061 0.545454545454545 16.1 16 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.004858230382574 0.0122142435236799 1.0230912456084 0.543478260869565 16.1 16 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 2.70195580094871e-05 0.000117222045876525 1.02041399748905 0.542056074766355 16.1 16 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.40355883007991e-08 1.88964873768161e-07 1.01968094145637 0.541666666666667 16.1 16 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00436978466621839 0.011123798890928 1.01968094145637 0.541666666666667 16.1 16 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.039324219899288 0.0759272251244055 1.01968094145637 0.541666666666667 16.1 16 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.58227415075451e-10 3.37117074910429e-09 1.01594584643272 0.53968253968254 16.1 16 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.58227415075451e-10 3.37117074910429e-09 1.01594584643272 0.53968253968254 16.1 16 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.58227415075451e-10 3.37117074910429e-09 1.01594584643272 0.53968253968254 16.1 16 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0349306607868983 0.0679048228138747 1.01364732641816 0.538461538461538 16.1 16 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.124361584200973 0.188462762851954 1.01364732641816 0.538461538461538 16.1 16 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.124361584200973 0.188462762851954 1.01364732641816 0.538461538461538 16.1 16 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.031048711150756 0.0606899944608872 1.00847565638542 0.535714285714286 16.1 16 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.031048711150756 0.0606899944608872 1.00847565638542 0.535714285714286 16.1 16 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.031048711150756 0.0606899944608872 1.00847565638542 0.535714285714286 16.1 16 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.11273636057481e-06 6.70942305549981e-06 1.00804190341493 0.535483870967742 16.1 16 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00781012320090384 0.0183699261403077 1.00399354235704 0.533333333333333 16.1 16 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.027615949044347 0.0544286641137199 1.00399354235704 0.533333333333333 16.1 16 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.108255252654643 0.177678459662696 1.00399354235704 0.533333333333333 16.1 16 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.108255252654643 0.177678459662696 1.00399354235704 0.533333333333333 16.1 16 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.108255252654643 0.177678459662696 1.00399354235704 0.533333333333333 16.1 16 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.61169149283391e-20 3.45391420752771e-18 1.00223523492734 0.532399299474606 16.1 16 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.25265946204548e-51 5.94178138163572e-49 0.997755041488617 0.530019367333764 16.1 16 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0218866870391137 0.0450720052918361 0.996611236898532 0.529411764705882 16.1 16 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0945708313770195 0.158136654582255 0.996611236898532 0.529411764705882 16.1 16 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0945708313770195 0.158136654582255 0.996611236898532 0.529411764705882 16.1 16 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0945708313770195 0.158136654582255 0.996611236898532 0.529411764705882 16.1 16 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0945708313770195 0.158136654582255 0.996611236898532 0.529411764705882 16.1 16 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0945708313770195 0.158136654582255 0.996611236898532 0.529411764705882 16.1 16 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0945708313770195 0.158136654582255 0.996611236898532 0.529411764705882 16.1 16 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.23503371812785e-21 1.09840811305995e-19 0.995405728231124 0.528771384136858 16.1 16 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.36042765511471e-07 9.48964977072659e-07 0.993800714515851 0.527918781725888 16.1 16 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00451768177205948 0.0114308455420197 0.992584524830255 0.527272727272727 16.1 16 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0828581568607812 0.141375488264858 0.990783101010237 0.526315789473684 16.1 16 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0155051451170794 0.0331786789497805 0.988306143257711 0.525 16.1 16 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00262342544344291 0.00695183315832265 0.984685974234789 0.523076923076923 16.1 16 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.71034727563468e-06 2.30559409643796e-05 0.983210236543916 0.522292993630573 16.1 16 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0640512591762153 0.111697232607542 0.98216759578406 0.521739130434783 16.1 16 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00985479668117105 0.0227850309015264 0.980462443708047 0.520833333333333 16.1 16 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0498744475371857 0.0908723928878556 0.976104832847122 0.518518518518518 16.1 16 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0498744475371857 0.0908723928878556 0.976104832847122 0.518518518518518 16.1 16 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0441060943949429 0.0817226202135466 0.973700633751439 0.517241379310345 16.1 16 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0390530864994071 0.0755061713161091 0.971606653893909 0.516129032258065 16.1 16 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 7.97696168354201e-06 3.77116826434561e-05 0.970475124405679 0.515527950310559 16.1 16 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00209938711905716 0.00575612306438987 0.966013523484981 0.513157894736842 16.1 16 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 1.08214627703762e-05 5.01594186392357e-05 0.96448453721799 0.512345679012346 16.1 16 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.000984211168887379 0.00303803143888664 0.962160478092163 0.511111111111111 16.1 16 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0170982841338819 0.0364234406025658 0.962160478092163 0.511111111111111 16.1 16 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 9.79246803745096e-13 2.01951913294097e-11 0.943145448880855 0.501010101010101 16.1 16 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.101247973725145 0.169095959483665 0.941243945959725 0.5 16.1 16 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.13280787568162 0.200834864075393 0.941243945959725 0.5 16.1 16 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.17694830697548 0.259050865047437 0.941243945959725 0.5 16.1 16 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.17694830697548 0.259050865047437 0.941243945959725 0.5 16.1 16 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00158837148403537 0.00452050524356467 0.941243945959725 0.5 16.1 16 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0605962397455389 0.106454875503582 0.941243945959725 0.5 16.1 16 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0887782984531423 0.151295231974636 0.941243945959725 0.5 16.1 16 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.115775912865288 0.185947092559035 0.941243945959725 0.5 16.1 16 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.15293187086008 0.227876494485753 0.941243945959725 0.5 16.1 16 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.15293187086008 0.227876494485753 0.941243945959725 0.5 16.1 16 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.15293187086008 0.227876494485753 0.941243945959725 0.5 16.1 16 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.20599224155581 0.296687206208418 0.941243945959725 0.5 16.1 16 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.20599224155581 0.296687206208418 0.941243945959725 0.5 16.1 16 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.241764031739256 0.334659744323892 0.941243945959725 0.5 16.1 16 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.241764031739256 0.334659744323892 0.941243945959725 0.5 16.1 16 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.241764031739256 0.334659744323892 0.941243945959725 0.5 16.1 16 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.241764031739256 0.334659744323892 0.941243945959725 0.5 16.1 16 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.241764031739256 0.334659744323892 0.941243945959725 0.5 16.1 16 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.241764031739256 0.334659744323892 0.941243945959725 0.5 16.1 16 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0231661983559547 0.0472962701011816 0.941243945959725 0.5 16.1 16 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0780205283661124 0.134248140102755 0.941243945959725 0.5 16.1 16 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 5.59412688780119e-05 0.000233444063382437 0.935469443223775 0.496932515337423 16.1 16 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 8.52475984313442e-05 0.000344623103885803 0.935171404372888 0.496774193548387 16.1 16 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00128685910967613 0.00378347213444035 0.924130419669548 0.490909090909091 16.1 16 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0193553471733338 0.0407435784432751 0.924130419669548 0.490909090909091 16.1 16 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0494535102673419 0.090336771643681 0.917109485806911 0.487179487179487 16.1 16 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0494535102673419 0.090336771643681 0.917109485806911 0.487179487179487 16.1 16 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0494535102673419 0.090336771643681 0.917109485806911 0.487179487179487 16.1 16 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 2.99104995179474e-06 1.60613738920902e-05 0.915405876854948 0.486274509803922 16.1 16 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00048429447304609 0.00162535621496365 0.914351261789447 0.485714285714286 16.1 16 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00230395848703295 0.00629276953368118 0.914351261789447 0.485714285714286 16.1 16 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0713270655089082 0.123800760981649 0.912721402142763 0.484848484848485 16.1 16 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0160314269612438 0.0342533341829579 0.911830072648483 0.484375 16.1 16 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0916546674837094 0.154348629383809 0.90878725816801 0.482758620689655 16.1 16 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000164472659849646 0.000625787687074989 0.908409854821595 0.482558139534884 16.1 16 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.000766931095191328 0.00241982915400723 0.906891977129078 0.481751824817518 16.1 16 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.104156174850116 0.171544255569114 0.906383059072328 0.481481481481481 16.1 16 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.118596178954653 0.187369811560884 0.903594188121336 0.48 16.1 16 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.118596178954653 0.187369811560884 0.903594188121336 0.48 16.1 16 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.118596178954653 0.187369811560884 0.903594188121336 0.48 16.1 16 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.118596178954653 0.187369811560884 0.903594188121336 0.48 16.1 16 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0400953322540537 0.076790925703255 0.902025448211403 0.479166666666667 16.1 16 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00079127842518868 0.00245313550989867 0.90147307500368 0.47887323943662 16.1 16 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.135344962061664 0.20423741358828 0.900320296135389 0.478260869565217 16.1 16 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.135344962061664 0.20423741358828 0.900320296135389 0.478260869565217 16.1 16 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000434346460056864 0.00147711821738285 0.899805533244517 0.477987421383648 16.1 16 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000434346460056864 0.00147711821738285 0.899805533244517 0.477987421383648 16.1 16 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0571045043887893 0.100444635037388 0.896422805675928 0.476190476190476 16.1 16 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.177762622620374 0.259975551889818 0.891704790909213 0.473684210526316 16.1 16 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.040773471551381 0.0778584191406553 0.887965986754457 0.471698113207547 16.1 16 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00191333806829707 0.00527651176586576 0.885876655020917 0.470588235294118 16.1 16 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.204808350400578 0.295580408336737 0.885876655020917 0.470588235294118 16.1 16 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.204808350400578 0.295580408336737 0.885876655020917 0.470588235294118 16.1 16 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00397337770551771 0.0101692742355246 0.879523031470562 0.467213114754098 16.1 16 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00238806024471908 0.00643600327317283 0.87941040206456 0.467153284671533 16.1 16 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.118830791754609 0.187369811560884 0.87849434956241 0.466666666666667 16.1 16 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0515073788926971 0.0928192341365781 0.87152217218493 0.462962962962963 16.1 16 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.275961376431384 0.373304419367961 0.868840565501284 0.461538461538462 16.1 16 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.275961376431384 0.373304419367961 0.868840565501284 0.461538461538462 16.1 16 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.174747523576567 0.256356418607685 0.862806950463081 0.458333333333333 16.1 16 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.174747523576567 0.256356418607685 0.862806950463081 0.458333333333333 16.1 16 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0234097640822077 0.047725063451263 0.850155822157171 0.451612903225806 16.1 16 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.150156076564696 0.224445479991138 0.850155822157171 0.451612903225806 16.1 16 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.228479021510899 0.321425884095788 0.847119551363752 0.45 16.1 16 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.228479021510899 0.321425884095788 0.847119551363752 0.45 16.1 16 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.228479021510899 0.321425884095788 0.847119551363752 0.45 16.1 16 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.000481366111876005 0.00161934746382873 0.846741541746901 0.449799196787149 16.1 16 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0110021992393685 0.0248116157173081 0.844896140467784 0.448818897637795 16.1 16 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.146036410205223 0.218517152178793 0.836661285297533 0.444444444444444 16.1 16 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.262408730175746 0.361129229245731 0.836661285297533 0.444444444444444 16.1 16 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.262408730175746 0.361129229245731 0.836661285297533 0.444444444444444 16.1 16 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00410606615112379 0.0104712045395146 0.834400038580513 0.443243243243243 16.1 16 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0385961150066925 0.0747241791218006 0.83428440664612 0.443181818181818 16.1 16 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0341866933818547 0.0665494728897118 0.832257804848599 0.442105263157895 16.1 16 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.12235972772553 0.187626868919533 0.823588452714759 0.4375 16.1 16 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.185394185071038 0.270858239585305 0.823588452714759 0.4375 16.1 16 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.302483619564316 0.405305264256141 0.823588452714759 0.4375 16.1 16 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.24894188679308 0.343592924254659 0.818472996486717 0.434782608695652 16.1 16 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.209145456891826 0.300620187027341 0.815744753165095 0.433333333333333 16.1 16 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.209145456891826 0.300620187027341 0.815744753165095 0.433333333333333 16.1 16 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.236150050266245 0.328807751006719 0.806780525108336 0.428571428571429 16.1 16 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.236150050266245 0.328807751006719 0.806780525108336 0.428571428571429 16.1 16 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.350221178523312 0.455127613733948 0.806780525108336 0.428571428571429 16.1 16 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.224158358973521 0.321425884095788 0.798631226874918 0.424242424242424 16.1 16 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.224158358973521 0.321425884095788 0.798631226874918 0.424242424242424 16.1 16 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.266893265271588 0.36694600626229 0.796437185042844 0.423076923076923 16.1 16 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0731670204329633 0.126049237380275 0.79569075844018 0.422680412371134 16.1 16 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.124738488492865 0.18883283949505 0.791190563270493 0.420289855072464 16.1 16 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.14356051440298 0.215038538942569 0.789430406288801 0.419354838709677 16.1 16 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.202497911590352 0.292839967675884 0.788018187315118 0.418604651162791 16.1 16 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.407691774189308 0.524543756484074 0.784369954966437 0.416666666666667 16.1 16 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.407691774189308 0.524543756484074 0.784369954966437 0.416666666666667 16.1 16 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.407691774189308 0.524543756484074 0.784369954966437 0.416666666666667 16.1 16 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0418717036614676 0.0779887883642256 0.780543760064162 0.414634146341463 16.1 16 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.22536898705978 0.321425884095788 0.780543760064162 0.414634146341463 16.1 16 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.370856307978932 0.480189741814395 0.775142073143303 0.411764705882353 16.1 16 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.317866337625568 0.425116351918406 0.766939511522739 0.407407407407407 16.1 16 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.166149716844908 0.244817875531663 0.762526741030663 0.40506329113924 16.1 16 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.357318809393222 0.463504708994124 0.75299515676778 0.4 16.1 16 1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.425665477868044 0.546357451250003 0.75299515676778 0.4 16.1 16 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.261988642503991 0.361129229245731 0.740650973869947 0.39344262295082 16.1 16 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.370741582387484 0.480189741814395 0.739548814682641 0.392857142857143 16.1 16 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.439868402944596 0.55638465545792 0.732078624635342 0.388888888888889 16.1 16 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.244170962596858 0.337335223082843 0.730848240392257 0.388235294117647 16.1 16 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.244170962596858 0.337335223082843 0.730848240392257 0.388235294117647 16.1 16 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.311730043684738 0.417301836466022 0.726574274074174 0.385964912280702 16.1 16 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.490023272788011 0.607936457870392 0.724033804584404 0.384615384615385 16.1 16 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.490023272788011 0.607936457870392 0.724033804584404 0.384615384615385 16.1 16 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.490023272788011 0.607936457870392 0.724033804584404 0.384615384615385 16.1 16 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.490023272788011 0.607936457870392 0.724033804584404 0.384615384615385 16.1 16 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.352202814861557 0.457285224040141 0.720952809671279 0.382978723404255 16.1 16 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.402940760229063 0.519841071446923 0.712292715861413 0.378378378378378 16.1 16 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.499574592850281 0.618707263382028 0.705932959469794 0.375 16.1 16 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.461581922324489 0.580752498203137 0.705932959469794 0.375 16.1 16 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.442436834995192 0.559136426463729 0.699209788427224 0.371428571428571 16.1 16 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.507476075521116 0.62794648301439 0.693548170707166 0.368421052631579 16.1 16 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.478010067855612 0.59615103116436 0.690245560370465 0.366666666666667 16.1 16 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.457304332499771 0.577412657628371 0.688715082409555 0.365853658536585 16.1 16 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.427197457547023 0.546357451250003 0.687257484351545 0.365079365079365 16.1 16 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.295473907234835 0.396285928364911 0.686554407641211 0.364705882352941 16.1 16 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.51425768161146 0.635785126788104 0.684541051607073 0.363636363636364 16.1 16 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.458398401242936 0.578280961851683 0.678930059380785 0.360655737704918 16.1 16 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.520229923348327 0.64261040010822 0.677695641091002 0.36 16.1 16 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.49709403391477 0.616171437509337 0.675764884278777 0.358974358974359 16.1 16 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.481090621266778 0.599467560475153 0.674854149933388 0.358490566037736 16.1 16 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.567691102935066 0.679505012785209 0.672317104256946 0.357142857142857 16.1 16 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.567691102935066 0.679505012785209 0.672317104256946 0.357142857142857 16.1 16 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.567691102935066 0.679505012785209 0.672317104256946 0.357142857142857 16.1 16 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.530469423630057 0.654690364115846 0.667979574552063 0.354838709677419 16.1 16 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.486399714080581 0.605552749900846 0.66721089840183 0.354430379746835 16.1 16 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.569784566416471 0.679505012785209 0.664407491265688 0.352941176470588 16.1 16 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.539136622009764 0.664810583292803 0.661414664728455 0.351351351351351 16.1 16 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.572008643178204 0.679505012785209 0.658870762171807 0.35 16.1 16 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.474170998627728 0.596064780077082 0.65473847167735 0.34780487804878 16.1 16 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.631309425362391 0.747382123369952 0.62749596397315 0.333333333333333 16.1 16 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.632215618885377 0.747832772796252 0.62749596397315 0.333333333333333 16.1 16 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.638703915468577 0.754253669470361 0.62749596397315 0.333333333333333 16.1 16 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.638703915468577 0.754253669470361 0.62749596397315 0.333333333333333 16.1 16 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.700008057817307 0.814481983870832 0.615428733896743 0.326923076923077 16.1 16 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.723884246243945 0.831386022925854 0.608480934761842 0.323232323232323 16.1 16 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.676241549710132 0.788117711087238 0.607254158683693 0.32258064516129 16.1 16 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.676241549710132 0.788117711087238 0.607254158683693 0.32258064516129 16.1 16 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.693481066289928 0.807547919255784 0.594469860606142 0.315789473684211 16.1 16 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.701944516658712 0.816067849023976 0.588277466224828 0.3125 16.1 16 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.729704435770786 0.834329686639933 0.579227043667523 0.307692307692308 16.1 16 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.771336496640823 0.87436927387927 0.576271803648811 0.306122448979592 16.1 16 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.745540676194953 0.849403028202897 0.564746367575835 0.3 16.1 16 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.771815039363611 0.87436927387927 0.557774190198355 0.296296296296296 16.1 16 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.849029869368637 0.945359549383075 0.556792193384626 0.295774647887324 16.1 16 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999779461554713 1 0.499732610483771 0.265463917525773 16.1 16 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.998819737153748 1 0.49751465715014 0.264285714285714 16.1 16 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.994208058773781 1 0.495924229591683 0.263440860215054 16.1 16 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.897747323344424 0.987244544914308 0.495391550505118 0.263157894736842 16.1 16 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.998090214185707 1 0.485803326946955 0.258064516129032 16.1 16 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.91277851357845 0.996841001398415 0.470621972979862 0.25 16.1 16 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.943333283947672 1 0.442938327510459 0.235294117647059 16.1 16 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.954719024911963 1 0.430282946724446 0.228571428571429 16.1 16 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.92434775411765 1 0.42783815725442 0.227272727272727 16.1 16 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.92434775411765 1 0.42783815725442 0.227272727272727 16.1 16 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.92434775411765 1 0.42783815725442 0.227272727272727 16.1 16 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.950390334254298 1 0.425077911078585 0.225806451612903 16.1 16 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999948366340491 1 0.406446249391699 0.215909090909091 16.1 16 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.355633732730375 0.188916876574307 16.1 16 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999991048103968 1 0.313747981986575 0.166666666666667 16.1 16 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.998374457792538 1 0.313747981986575 0.166666666666667 16.1 16 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.297862008215103 0.158227848101266 16.1 16 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999995855245411 1 0.271914917721698 0.144444444444444 16.1 16 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999966219826666 1 0.200264669353133 0.106382978723404 16.1 16 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0151813539670923 0.00806451612903226 16.1 16 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 1.11881574177549e-05 6.95229170544334e-05 3.15684352407793 1 16.3 16 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.000804965719616749 0.00282831165188798 3.15684352407793 1 16.3 16 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 5.55736377450055e-06 3.69538722014686e-05 2.86985774916176 0.909090909090909 16.3 16 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 2.1076821998204e-05 0.000121426387463337 2.84115917167014 0.9 16.3 16 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 2.05864748247542e-06 1.45744048137439e-05 2.70586587778108 0.857142857142857 16.3 16 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00107568092121467 0.00363585261493701 2.70586587778108 0.857142857142857 16.3 16 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00107568092121467 0.00363585261493701 2.70586587778108 0.857142857142857 16.3 16 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 2.60754668299061e-05 0.000146084209838411 2.63070293673161 0.833333333333333 16.3 16 3 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00386200334373396 0.0113781175116634 2.63070293673161 0.833333333333333 16.3 16 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00386200334373396 0.0113781175116634 2.63070293673161 0.833333333333333 16.3 16 3 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.00386200334373396 0.0113781175116634 2.63070293673161 0.833333333333333 16.3 16 3 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.00386200334373396 0.0113781175116634 2.63070293673161 0.833333333333333 16.3 16 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 9.09143840048694e-05 0.000429804546308735 2.58287197424558 0.818181818181818 16.3 16 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 9.09143840048694e-05 0.000429804546308735 2.58287197424558 0.818181818181818 16.3 16 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.000311579836581064 0.00120156668686952 2.52547481926235 0.8 16.3 16 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000311579836581064 0.00120156668686952 2.52547481926235 0.8 16.3 16 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000311579836581064 0.00120156668686952 2.52547481926235 0.8 16.3 16 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.000311579836581064 0.00120156668686952 2.52547481926235 0.8 16.3 16 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00104581070816988 0.00355176285853399 2.4553227409495 0.777777777777778 16.3 16 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00104581070816988 0.00355176285853399 2.4553227409495 0.777777777777778 16.3 16 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00104581070816988 0.00355176285853399 2.4553227409495 0.777777777777778 16.3 16 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 7.79885486185913e-06 4.9769139479376e-05 2.41405681253018 0.764705882352941 16.3 16 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 6.47832640458213e-08 5.79789841114489e-07 2.39920107829923 0.76 16.3 16 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00028543113552976 0.00112201244712389 2.36763264305845 0.75 16.3 16 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00028543113552976 0.00112201244712389 2.36763264305845 0.75 16.3 16 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00028543113552976 0.00112201244712389 2.36763264305845 0.75 16.3 16 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00028543113552976 0.00112201244712389 2.36763264305845 0.75 16.3 16 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00028543113552976 0.00112201244712389 2.36763264305845 0.75 16.3 16 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00028543113552976 0.00112201244712389 2.36763264305845 0.75 16.3 16 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00028543113552976 0.00112201244712389 2.36763264305845 0.75 16.3 16 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.24952384004671e-06 1.58468931900321e-05 2.36763264305845 0.75 16.3 16 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00342076922127764 0.0102912359447739 2.36763264305845 0.75 16.3 16 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.74113851727632e-08 1.85001270872631e-07 2.31501858432382 0.733333333333333 16.3 16 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 7.86503552574558e-05 0.000379354512157692 2.31501858432382 0.733333333333333 16.3 16 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000900021043450912 0.00312373157275768 2.2958861993294 0.727272727272727 16.3 16 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.000900021043450912 0.00312373157275768 2.2958861993294 0.727272727272727 16.3 16 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 2.18498441970317e-05 0.000125266449637703 2.2799425451674 0.722222222222222 16.3 16 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 6.11061448299365e-06 4.02565018949073e-05 2.25488823148424 0.714285714285714 16.3 16 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000242341196257429 0.000990952650213569 2.25488823148424 0.714285714285714 16.3 16 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.000242341196257429 0.000990952650213569 2.25488823148424 0.714285714285714 16.3 16 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0108278094000322 0.0277121812522406 2.25488823148424 0.714285714285714 16.3 16 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0108278094000322 0.0277121812522406 2.25488823148424 0.714285714285714 16.3 16 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0108278094000322 0.0277121812522406 2.25488823148424 0.714285714285714 16.3 16 3 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0108278094000322 0.0277121812522406 2.25488823148424 0.714285714285714 16.3 16 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0108278094000322 0.0277121812522406 2.25488823148424 0.714285714285714 16.3 16 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0108278094000322 0.0277121812522406 2.25488823148424 0.714285714285714 16.3 16 3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0108278094000322 0.0277121812522406 2.25488823148424 0.714285714285714 16.3 16 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 4.62650354285896e-08 4.44832063614074e-07 2.24034056547466 0.709677419354839 16.3 16 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.71817858097581e-06 1.22862719634602e-05 2.23609749622187 0.708333333333333 16.3 16 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 6.62633161930281e-05 0.00032740520466208 2.22836013464325 0.705882352941177 16.3 16 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 6.62633161930281e-05 0.00032740520466208 2.22836013464325 0.705882352941177 16.3 16 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 6.62633161930281e-05 0.00032740520466208 2.22836013464325 0.705882352941177 16.3 16 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00275901607521046 0.00864775302868828 2.20979046685455 0.7 16.3 16 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00275901607521046 0.00864775302868828 2.20979046685455 0.7 16.3 16 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.11499542970874e-08 1.22049115113503e-07 2.19225244727634 0.694444444444444 16.3 16 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.43183674655253e-06 1.05025963419807e-05 2.18550705513088 0.692307692307692 16.3 16 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.000728703562925475 0.00258589817965823 2.18550705513088 0.692307692307692 16.3 16 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000728703562925475 0.00258589817965823 2.18550705513088 0.692307692307692 16.3 16 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000196693710560542 0.000820806891869944 2.17032992280358 0.6875 16.3 16 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000196693710560542 0.000820806891869944 2.17032992280358 0.6875 16.3 16 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000196693710560542 0.000820806891869944 2.17032992280358 0.6875 16.3 16 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000196693710560542 0.000820806891869944 2.17032992280358 0.6875 16.3 16 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.63707735449697e-09 3.20731715850358e-08 2.15589313839468 0.682926829268293 16.3 16 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 1.49107305515172e-05 8.87781153757697e-05 2.15239331187132 0.681818181818182 16.3 16 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 7.5448282368851e-09 8.53527457342191e-08 2.1308693787526 0.675 16.3 16 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.15423277542954e-09 2.73702967806807e-08 2.1290340046107 0.674418604651163 16.3 16 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 5.06912049762774e-11 9.2478954719542e-10 2.12479852582169 0.673076923076923 16.3 16 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 5.06912049762774e-11 9.2478954719542e-10 2.12479852582169 0.673076923076923 16.3 16 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 3.32498923590069e-06 2.3080291135057e-05 2.10456234938529 0.666666666666667 16.3 16 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 1.18791194425166e-05 7.25493002862707e-05 2.10456234938529 0.666666666666667 16.3 16 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 4.27314976388979e-05 0.000225210819037599 2.10456234938529 0.666666666666667 16.3 16 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00212920085929322 0.00682399284408615 2.10456234938529 0.666666666666667 16.3 16 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00212920085929322 0.00682399284408615 2.10456234938529 0.666666666666667 16.3 16 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00817068624749315 0.0220624032830792 2.10456234938529 0.666666666666667 16.3 16 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00817068624749315 0.0220624032830792 2.10456234938529 0.666666666666667 16.3 16 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00817068624749315 0.0220624032830792 2.10456234938529 0.666666666666667 16.3 16 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00817068624749315 0.0220624032830792 2.10456234938529 0.666666666666667 16.3 16 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00817068624749315 0.0220624032830792 2.10456234938529 0.666666666666667 16.3 16 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 2.64471706448547e-07 2.21378375456637e-06 2.10456234938529 0.666666666666667 16.3 16 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.14603624287614e-10 1.66409140164566e-09 2.08470798759863 0.660377358490566 16.3 16 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 5.26060081414602e-14 1.91944486116148e-12 2.07573272816083 0.657534246575342 16.3 16 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 7.39775870304538e-07 5.75246482755933e-06 2.07167856267614 0.65625 16.3 16 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.34293334367289e-08 1.44772283942918e-07 2.05561903893447 0.651162790697674 16.3 16 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000119904420774512 0.00055039997020042 2.05194829065066 0.65 16.3 16 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 5.78410029540708e-07 4.54738934826755e-06 2.04266345675631 0.647058823529412 16.3 16 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.02080169828824e-09 3.61226959383543e-08 2.038794775967 0.645833333333333 16.3 16 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.05172758348161e-08 1.16016151263127e-07 2.03441027107244 0.644444444444444 16.3 16 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.11674438034772e-13 9.23984844423917e-12 2.03248829632415 0.643835616438356 16.3 16 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00160415582292796 0.00525970906918544 2.02939940833581 0.642857142857143 16.3 16 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.8424308812234e-08 2.84843601688796e-07 2.00890042441323 0.636363636363636 16.3 16 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 9.14178400418145e-05 0.000430753597283119 2.00890042441323 0.636363636363636 16.3 16 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00601225738078967 0.0169079886420231 2.00890042441323 0.636363636363636 16.3 16 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00601225738078967 0.0169079886420231 2.00890042441323 0.636363636363636 16.3 16 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00601225738078967 0.0169079886420231 2.00890042441323 0.636363636363636 16.3 16 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.00601225738078967 0.0169079886420231 2.00890042441323 0.636363636363636 16.3 16 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00601225738078967 0.0169079886420231 2.00890042441323 0.636363636363636 16.3 16 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00601225738078967 0.0169079886420231 2.00890042441323 0.636363636363636 16.3 16 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00601225738078967 0.0169079886420231 2.00890042441323 0.636363636363636 16.3 16 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00601225738078967 0.0169079886420231 2.00890042441323 0.636363636363636 16.3 16 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 5.52577777798899e-06 3.69163463759546e-05 1.99933423191602 0.633333333333333 16.3 16 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 5.52577777798899e-06 3.69163463759546e-05 1.99933423191602 0.633333333333333 16.3 16 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.47926462471149e-13 4.57607295861836e-12 1.99800223042907 0.632911392405063 16.3 16 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.47926462471149e-13 4.57607295861836e-12 1.99800223042907 0.632911392405063 16.3 16 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.44557275331193e-07 2.83413296414039e-06 1.99379590994396 0.631578947368421 16.3 16 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000328605612441392 0.00126379942298406 1.99379590994396 0.631578947368421 16.3 16 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.94892663563347e-05 0.00011319684091863 1.98764221886388 0.62962962962963 16.3 16 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.05040445774304e-11 4.10947259629344e-10 1.97891683598915 0.626865671641791 16.3 16 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.34350413403374e-12 3.08355868182259e-11 1.97828860842217 0.626666666666667 16.3 16 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.34350413403374e-12 3.08355868182259e-11 1.97828860842217 0.626666666666667 16.3 16 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.34350413403374e-12 3.08355868182259e-11 1.97828860842217 0.626666666666667 16.3 16 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.34350413403374e-12 3.08355868182259e-11 1.97828860842217 0.626666666666667 16.3 16 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.34350413403374e-12 3.08355868182259e-11 1.97828860842217 0.626666666666667 16.3 16 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 8.70873640944484e-17 4.58982663357037e-15 1.97302720254871 0.625 16.3 16 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 6.89912741499903e-05 0.000336214325737795 1.97302720254871 0.625 16.3 16 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 6.89912741499903e-05 0.000336214325737795 1.97302720254871 0.625 16.3 16 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.63233658313694e-07 2.21378375456637e-06 1.97302720254871 0.625 16.3 16 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0011914381577521 0.00397985093540195 1.97302720254871 0.625 16.3 16 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0011914381577521 0.00397985093540195 1.97302720254871 0.625 16.3 16 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.023172876364623 0.0533576101405479 1.97302720254871 0.625 16.3 16 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.023172876364623 0.0533576101405479 1.97302720254871 0.625 16.3 16 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.023172876364623 0.0533576101405479 1.97302720254871 0.625 16.3 16 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.023172876364623 0.0533576101405479 1.97302720254871 0.625 16.3 16 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.023172876364623 0.0533576101405479 1.97302720254871 0.625 16.3 16 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.5744541400929e-11 3.24702643674231e-10 1.96730828312103 0.623188405797101 16.3 16 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.95765529490799e-20 1.74108967790879e-18 1.96695634961779 0.623076923076923 16.3 16 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.21614678236483e-14 1.91944486116148e-12 1.9594201183932 0.620689655172414 16.3 16 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.47192237948618e-05 8.8377449198685e-05 1.9594201183932 0.620689655172414 16.3 16 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 5.14429983908244e-17 2.81551487346704e-15 1.95841218623353 0.62037037037037 16.3 16 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7.91451544373458e-13 1.97585183797093e-11 1.95804218582049 0.620253164556962 16.3 16 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000245310420869884 0.000996280112067708 1.95423646728634 0.619047619047619 16.3 16 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000245310420869884 0.000996280112067708 1.95423646728634 0.619047619047619 16.3 16 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 6.04813822415794e-13 1.53687512374585e-11 1.94866884202341 0.617283950617284 16.3 16 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 6.04813822415794e-13 1.53687512374585e-11 1.94866884202341 0.617283950617284 16.3 16 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.01732429639133e-15 9.89880163367196e-14 1.94512580776519 0.616161616161616 16.3 16 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0043699965334816 0.0127167792784137 1.94267293789411 0.615384615384615 16.3 16 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0043699965334816 0.0127167792784137 1.94267293789411 0.615384615384615 16.3 16 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0043699965334816 0.0127167792784137 1.94267293789411 0.615384615384615 16.3 16 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0043699965334816 0.0127167792784137 1.94267293789411 0.615384615384615 16.3 16 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 4.60979767417663e-13 1.21476705376914e-11 1.93974722563825 0.614457831325301 16.3 16 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.03376847163358e-13 3.38607244276698e-12 1.93715398068419 0.613636363636364 16.3 16 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.32005542444555e-14 9.71011432054713e-13 1.93483957927357 0.612903225806452 16.3 16 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 3.32838519892207e-08 3.26640837108008e-07 1.9327613412722 0.612244897959184 16.3 16 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.06494067559982e-10 1.56227894987478e-09 1.9317997684656 0.611940298507463 16.3 16 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.5049988593467e-13 9.59156418625067e-12 1.93124545002415 0.611764705882353 16.3 16 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.5049988593467e-13 9.59156418625067e-12 1.93124545002415 0.611764705882353 16.3 16 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.5049988593467e-13 9.59156418625067e-12 1.93124545002415 0.611764705882353 16.3 16 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.5049988593467e-13 9.59156418625067e-12 1.93124545002415 0.611764705882353 16.3 16 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.37554536420234e-11 4.69500146286102e-10 1.92918215360318 0.611111111111111 16.3 16 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.38740814288362e-06 1.67353782626768e-05 1.92918215360318 0.611111111111111 16.3 16 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000876956706026067 0.00305972705884344 1.92918215360318 0.611111111111111 16.3 16 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.99519857761745e-18 2.13108378797481e-16 1.9249045878524 0.609756097560976 16.3 16 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 5.20010423689747e-07 4.1339376140252e-06 1.9249045878524 0.609756097560976 16.3 16 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 5.20010423689747e-07 4.1339376140252e-06 1.9249045878524 0.609756097560976 16.3 16 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 5.20010423689747e-07 4.1339376140252e-06 1.9249045878524 0.609756097560976 16.3 16 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 5.20010423689747e-07 4.1339376140252e-06 1.9249045878524 0.609756097560976 16.3 16 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 8.06113970004539e-11 1.21301340059914e-09 1.92155692769961 0.608695652173913 16.3 16 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 3.84685181742836e-05 0.000203497031085522 1.9166549967616 0.607142857142857 16.3 16 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 3.84685181742836e-05 0.000203497031085522 1.9166549967616 0.607142857142857 16.3 16 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 8.63584097900977e-14 2.92590516979307e-12 1.89410611444676 0.6 16.3 16 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000134073859651595 0.00060760223657395 1.89410611444676 0.6 16.3 16 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.000134073859651595 0.00060760223657395 1.89410611444676 0.6 16.3 16 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000134073859651595 0.00060760223657395 1.89410611444676 0.6 16.3 16 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000641657399941714 0.00229994579374574 1.89410611444676 0.6 16.3 16 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000641657399941714 0.00229994579374574 1.89410611444676 0.6 16.3 16 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000641657399941714 0.00229994579374574 1.89410611444676 0.6 16.3 16 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0162881915059172 0.0388894236793962 1.89410611444676 0.6 16.3 16 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0162881915059172 0.0388894236793962 1.89410611444676 0.6 16.3 16 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0162881915059172 0.0388894236793962 1.89410611444676 0.6 16.3 16 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0162881915059172 0.0388894236793962 1.89410611444676 0.6 16.3 16 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0162881915059172 0.0388894236793962 1.89410611444676 0.6 16.3 16 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0162881915059172 0.0388894236793962 1.89410611444676 0.6 16.3 16 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00315580523993383 0.00974123830027296 1.89410611444676 0.6 16.3 16 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00315580523993383 0.00974123830027296 1.89410611444676 0.6 16.3 16 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00315580523993383 0.00974123830027296 1.89410611444676 0.6 16.3 16 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00315580523993383 0.00974123830027296 1.89410611444676 0.6 16.3 16 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00315580523993383 0.00974123830027296 1.89410611444676 0.6 16.3 16 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.7881665104103e-17 1.58702437772554e-15 1.88392274824006 0.596774193548387 16.3 16 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.7881665104103e-17 1.58702437772554e-15 1.88392274824006 0.596774193548387 16.3 16 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.7881665104103e-17 1.58702437772554e-15 1.88392274824006 0.596774193548387 16.3 16 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.34107130770846e-09 2.94809245209658e-08 1.88392274824006 0.596774193548387 16.3 16 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 4.77838103865309e-08 4.5635142402707e-07 1.88196440858492 0.596153846153846 16.3 16 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.17045788401962e-07 1.84943806524546e-06 1.88067273774856 0.595744680851064 16.3 16 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 7.87608227427408e-09 8.75598834085314e-08 1.87270378546996 0.593220338983051 16.3 16 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 7.87608227427408e-09 8.75598834085314e-08 1.87270378546996 0.593220338983051 16.3 16 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 9.84751102940899e-05 0.000456449778333843 1.87072208834248 0.592592592592593 16.3 16 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 9.84751102940899e-05 0.000456449778333843 1.87072208834248 0.592592592592593 16.3 16 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.000467599704288208 0.00171493396701577 1.86540753695514 0.590909090909091 16.3 16 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 3.36226788057622e-06 2.32257630779609e-05 1.86172823214852 0.58974358974359 16.3 16 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.54995520293083e-05 9.18994272404405e-05 1.85696677886937 0.588235294117647 16.3 16 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 5.05978482681044e-14 1.91944486116148e-12 1.85161014393033 0.586538461538462 16.3 16 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.96124514780437e-08 2.01934244403418e-07 1.85056344514913 0.586206896551724 16.3 16 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.96124514780437e-08 2.01934244403418e-07 1.85056344514913 0.586206896551724 16.3 16 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0114485365108847 0.0288341016902459 1.84149205571213 0.583333333333333 16.3 16 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0114485365108847 0.0288341016902459 1.84149205571213 0.583333333333333 16.3 16 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0114485365108847 0.0288341016902459 1.84149205571213 0.583333333333333 16.3 16 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0114485365108847 0.0288341016902459 1.84149205571213 0.583333333333333 16.3 16 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0114485365108847 0.0288341016902459 1.84149205571213 0.583333333333333 16.3 16 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.13846236104798e-05 7.01312528039514e-05 1.84149205571213 0.583333333333333 16.3 16 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.39357259178312e-09 2.96178591139772e-08 1.8375656334185 0.582089552238806 16.3 16 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.39357259178312e-09 2.96178591139772e-08 1.8375656334185 0.582089552238806 16.3 16 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 5.26873033128887e-05 0.000266811503965269 1.83300591720654 0.580645161290323 16.3 16 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 2.95672999996922e-07 2.46048350289836e-06 1.8309692439652 0.58 16.3 16 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.82163286139858e-12 4.0502868152659e-11 1.82764625078196 0.578947368421053 16.3 16 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.82163286139858e-12 4.0502868152659e-11 1.82764625078196 0.578947368421053 16.3 16 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 8.34589969005121e-06 5.2783178928635e-05 1.82764625078196 0.578947368421053 16.3 16 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.001630939459705 0.00531081659304395 1.82764625078196 0.578947368421053 16.3 16 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.001630939459705 0.00531081659304395 1.82764625078196 0.578947368421053 16.3 16 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000246444553371633 0.000996280112067708 1.82125587927573 0.576923076923077 16.3 16 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.000246444553371633 0.000996280112067708 1.82125587927573 0.576923076923077 16.3 16 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 3.84251503234778e-05 0.000203497031085522 1.81757657446911 0.575757575757576 16.3 16 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 3.84251503234778e-05 0.000203497031085522 1.81757657446911 0.575757575757576 16.3 16 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.59962220939337e-10 2.27626240396677e-09 1.81518502634481 0.575 16.3 16 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.44635755485834e-15 1.63472226685447e-13 1.81130366135619 0.573770491803279 16.3 16 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.17420568316573e-07 1.02508876511953e-06 1.80391058518739 0.571428571428571 16.3 16 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000178483899787164 0.000760426914362678 1.80391058518739 0.571428571428571 16.3 16 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00117012003870415 0.00392707739404718 1.80391058518739 0.571428571428571 16.3 16 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00805778414755315 0.0220081129404379 1.80391058518739 0.571428571428571 16.3 16 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00805778414755315 0.0220081129404379 1.80391058518739 0.571428571428571 16.3 16 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00805778414755315 0.0220081129404379 1.80391058518739 0.571428571428571 16.3 16 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00805778414755315 0.0220081129404379 1.80391058518739 0.571428571428571 16.3 16 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 3.17096138261884e-09 3.76023170622218e-08 1.80391058518739 0.571428571428571 16.3 16 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 4.95829920987155e-14 1.91944486116148e-12 1.79995464092163 0.570175438596491 16.3 16 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.96855229225788e-19 4.71847217326831e-17 1.79545475431932 0.56875 16.3 16 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 5.27728497085677e-07 4.17198695196066e-06 1.79506788624039 0.568627450980392 16.3 16 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 6.31019384520854e-08 5.69520615359519e-07 1.78887799697749 0.566666666666667 16.3 16 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 6.31019384520854e-08 5.69520615359519e-07 1.78887799697749 0.566666666666667 16.3 16 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 6.31019384520854e-08 5.69520615359519e-07 1.78887799697749 0.566666666666667 16.3 16 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 6.31019384520854e-08 5.69520615359519e-07 1.78887799697749 0.566666666666667 16.3 16 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 6.31019384520854e-08 5.69520615359519e-07 1.78887799697749 0.566666666666667 16.3 16 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 6.31019384520854e-08 5.69520615359519e-07 1.78887799697749 0.566666666666667 16.3 16 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 6.31019384520854e-08 5.69520615359519e-07 1.78887799697749 0.566666666666667 16.3 16 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.91737923078823e-24 4.28802357339358e-22 1.78887799697749 0.566666666666667 16.3 16 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000839101210138664 0.00294098773898354 1.78430286143535 0.565217391304348 16.3 16 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.53180176286026e-10 2.20177162479813e-09 1.7826881077146 0.564705882352941 16.3 16 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 9.33615619057118e-05 0.000438460404593491 1.77572448229384 0.5625 16.3 16 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00568142005988178 0.0162342585245216 1.77572448229384 0.5625 16.3 16 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00568142005988178 0.0162342585245216 1.77572448229384 0.5625 16.3 16 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00568142005988178 0.0162342585245216 1.77572448229384 0.5625 16.3 16 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00568142005988178 0.0162342585245216 1.77572448229384 0.5625 16.3 16 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.07453242530373e-05 6.73594555597888e-05 1.77091222082421 0.560975609756098 16.3 16 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.47137643296832e-08 2.49416217313044e-07 1.76974561198308 0.560606060606061 16.3 16 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.08218208410431e-24 1.28328758806703e-22 1.76953112336207 0.560538116591928 16.3 16 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000601639116361495 0.00217292503193505 1.76783237348364 0.56 16.3 16 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 6.74642414960928e-05 0.000332185521276609 1.7641184399259 0.558823529411765 16.3 16 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.65740336991468e-10 3.70733823077313e-09 1.76195917622954 0.558139534883721 16.3 16 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 7.79938025572793e-06 4.9769139479376e-05 1.76195917622954 0.558139534883721 16.3 16 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00401332515728821 0.0117751787604559 1.75380195782107 0.555555555555556 16.3 16 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0419256140110354 0.0898496215929268 1.75380195782107 0.555555555555556 16.3 16 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0419256140110354 0.0898496215929268 1.75380195782107 0.555555555555556 16.3 16 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0419256140110354 0.0898496215929268 1.75380195782107 0.555555555555556 16.3 16 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0419256140110354 0.0898496215929268 1.75380195782107 0.555555555555556 16.3 16 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0419256140110354 0.0898496215929268 1.75380195782107 0.555555555555556 16.3 16 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0419256140110354 0.0898496215929268 1.75380195782107 0.555555555555556 16.3 16 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0419256140110354 0.0898496215929268 1.75380195782107 0.555555555555556 16.3 16 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0419256140110354 0.0898496215929268 1.75380195782107 0.555555555555556 16.3 16 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.35965649234185e-28 1.04727911886025e-25 1.75380195782107 0.555555555555556 16.3 16 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 5.65840566443824e-06 3.74507500488168e-05 1.75380195782107 0.555555555555556 16.3 16 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000431406357218562 0.00159452271771952 1.75380195782107 0.555555555555556 16.3 16 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000431406357218562 0.00159452271771952 1.75380195782107 0.555555555555556 16.3 16 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000431406357218562 0.00159452271771952 1.75380195782107 0.555555555555556 16.3 16 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000431406357218562 0.00159452271771952 1.75380195782107 0.555555555555556 16.3 16 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000309401497213257 0.00120156668686952 1.74170677190507 0.551724137931034 16.3 16 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 2.54126054787033e-05 0.000142933350182588 1.73626393824286 0.55 16.3 16 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.64883461556687e-12 5.67073367704145e-11 1.73484193665544 0.54954954954955 16.3 16 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.324688272675e-05 7.98742123735817e-05 1.72191464949705 0.545454545454545 16.3 16 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00201314444000327 0.00654042131991931 1.72191464949705 0.545454545454545 16.3 16 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0286193124560701 0.0650563604233032 1.72191464949705 0.545454545454545 16.3 16 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0286193124560701 0.0650563604233032 1.72191464949705 0.545454545454545 16.3 16 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0286193124560701 0.0650563604233032 1.72191464949705 0.545454545454545 16.3 16 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0286193124560701 0.0650563604233032 1.72191464949705 0.545454545454545 16.3 16 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0286193124560701 0.0650563604233032 1.72191464949705 0.545454545454545 16.3 16 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0286193124560701 0.0650563604233032 1.72191464949705 0.545454545454545 16.3 16 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 1.13213960735287e-06 8.52399291673619e-06 1.72191464949705 0.545454545454545 16.3 16 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.000159285255804393 0.000684782232657556 1.72191464949705 0.545454545454545 16.3 16 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.000159285255804393 0.000684782232657556 1.72191464949705 0.545454545454545 16.3 16 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 7.35752050113869e-29 1.16330574145782e-26 1.71309938678632 0.542662116040956 16.3 16 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00142918141813423 0.00470769712501161 1.70995690887555 0.541666666666667 16.3 16 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 8.21168616897211e-05 0.000390810348443054 1.70640190490699 0.540540540540541 16.3 16 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 8.21168616897211e-05 0.000390810348443054 1.70640190490699 0.540540540540541 16.3 16 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 8.21168616897211e-05 0.000390810348443054 1.70640190490699 0.540540540540541 16.3 16 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.11649155805977e-07 2.57835319018549e-06 1.70369333045476 0.53968253968254 16.3 16 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.001016032773183 0.00348389068973351 1.69983882065735 0.538461538461538 16.3 16 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.001016032773183 0.00348389068973351 1.69983882065735 0.538461538461538 16.3 16 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.001016032773183 0.00348389068973351 1.69983882065735 0.538461538461538 16.3 16 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.001016032773183 0.00348389068973351 1.69983882065735 0.538461538461538 16.3 16 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0197068331511883 0.046505511731577 1.69983882065735 0.538461538461538 16.3 16 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0197068331511883 0.046505511731577 1.69983882065735 0.538461538461538 16.3 16 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0197068331511883 0.046505511731577 1.69983882065735 0.538461538461538 16.3 16 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0197068331511883 0.046505511731577 1.69983882065735 0.538461538461538 16.3 16 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0197068331511883 0.046505511731577 1.69983882065735 0.538461538461538 16.3 16 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.29292395736933e-40 1.52720769783414e-37 1.69698865496208 0.537558685446009 16.3 16 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.59978329462318e-06 1.81347628835725e-05 1.69534189256037 0.537037037037037 16.3 16 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 3.10653724988621e-16 1.57878660949574e-14 1.69391603731011 0.536585365853659 16.3 16 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000723239961947099 0.00257937460112963 1.69116617361318 0.535714285714286 16.3 16 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.98374938473098e-09 4.68502097063817e-08 1.68854421055331 0.534883720930233 16.3 16 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.09572457773661e-09 2.68668114785513e-08 1.68364987950823 0.533333333333333 16.3 16 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.19194279408208e-05 0.000125266449637703 1.68364987950823 0.533333333333333 16.3 16 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.000515421592629634 0.00188062801618454 1.68364987950823 0.533333333333333 16.3 16 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0136600457562609 0.0338645385211835 1.68364987950823 0.533333333333333 16.3 16 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 7.16550190203697e-11 1.21301340059914e-09 1.68168299880787 0.532710280373832 16.3 16 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.57689424099628e-05 9.31087346447178e-05 1.6791720872755 0.531914893617021 16.3 16 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.11268073430787e-07 4.1339376140252e-06 1.6770731221664 0.53125 16.3 16 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 1.13478992161169e-05 7.01312528039514e-05 1.67505982910258 0.530612244897959 16.3 16 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00951825710733838 0.0249437934875553 1.67127010098243 0.529411764705882 16.3 16 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00951825710733838 0.0249437934875553 1.67127010098243 0.529411764705882 16.3 16 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.52148237801557e-46 7.21689807972052e-44 1.66844581690811 0.52851711026616 16.3 16 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 8.42700393202363e-11 1.24912777034059e-09 1.66451749451382 0.527272727272727 16.3 16 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 7.28681560940449e-08 6.48071163261412e-07 1.66149659161996 0.526315789473684 16.3 16 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0066604203768251 0.0186203893835405 1.66149659161996 0.526315789473684 16.3 16 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 9.3579869097201e-10 1.23300142338256e-08 1.65814003284901 0.525252525252525 16.3 16 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 9.61076491558677e-05 0.000449872318252631 1.65734285014091 0.525 16.3 16 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.58565560790303e-06 1.1453745837797e-05 1.65604906181137 0.524590163934426 16.3 16 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.58565560790303e-06 1.1453745837797e-05 1.65604906181137 0.524590163934426 16.3 16 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.14325547589623e-06 8.56238180105442e-06 1.65358470308844 0.523809523809524 16.3 16 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 6.8848273696145e-05 0.000336214325737795 1.65358470308844 0.523809523809524 16.3 16 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00467699810953167 0.013582384305844 1.65358470308844 0.523809523809524 16.3 16 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 7.22941638250388e-19 5.41445237489633e-17 1.65358470308844 0.523809523809524 16.3 16 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 8.2446929179036e-07 6.34172866063612e-06 1.65127199720999 0.523076923076923 16.3 16 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 3.53981310936553e-05 0.000190801289947998 1.64704879517109 0.521739130434783 16.3 16 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 3.53981310936553e-05 0.000190801289947998 1.64704879517109 0.521739130434783 16.3 16 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 3.53981310936553e-05 0.000190801289947998 1.64704879517109 0.521739130434783 16.3 16 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 3.53981310936553e-05 0.000190801289947998 1.64704879517109 0.521739130434783 16.3 16 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00329391887258287 0.0101455553153364 1.64704879517109 0.521739130434783 16.3 16 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 2.54034992543559e-05 0.000142933350182588 1.64418933545726 0.520833333333333 16.3 16 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.61298338581989e-07 1.38469832393393e-06 1.64155863252052 0.52 16.3 16 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00232568557838803 0.00737071398228546 1.64155863252052 0.52 16.3 16 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00232568557838803 0.00737071398228546 1.64155863252052 0.52 16.3 16 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00232568557838803 0.00737071398228546 1.64155863252052 0.52 16.3 16 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00232568557838803 0.00737071398228546 1.64155863252052 0.52 16.3 16 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00232568557838803 0.00737071398228546 1.64155863252052 0.52 16.3 16 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 6.77073048210327e-06 4.35961514752622e-05 1.63479396782607 0.517857142857143 16.3 16 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 6.79061877096878e-07 5.30936841268603e-06 1.62351952666865 0.514285714285714 16.3 16 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00041954052790272 0.00156694533124822 1.62351952666865 0.514285714285714 16.3 16 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00041954052790272 0.00156694533124822 1.62351952666865 0.514285714285714 16.3 16 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00041954052790272 0.00156694533124822 1.62351952666865 0.514285714285714 16.3 16 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.90206300022794e-26 2.46057786302215e-24 1.61715603840802 0.512269938650307 16.3 16 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00015250511889516 0.000661630439596989 1.61691985379601 0.51219512195122 16.3 16 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00015250511889516 0.000661630439596989 1.61691985379601 0.51219512195122 16.3 16 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00015250511889516 0.000661630439596989 1.61691985379601 0.51219512195122 16.3 16 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00015250511889516 0.000661630439596989 1.61691985379601 0.51219512195122 16.3 16 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.84948930994843e-14 7.97522208502005e-13 1.61556109761635 0.511764705882353 16.3 16 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.53970493006493e-11 4.9506850897019e-10 1.61512924487708 0.511627906976744 16.3 16 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 7.80321072373155e-05 0.000377686015641836 1.61349780119539 0.511111111111111 16.3 16 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.94827776742583e-22 3.74559950869797e-20 1.61323988914277 0.511029411764706 16.3 16 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 5.10735418001537e-09 5.90875203102591e-08 1.60999019727975 0.51 16.3 16 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.87144305316847e-05 0.000159611854088232 1.60937120835346 0.509803921568627 16.3 16 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.87144305316847e-05 0.000159611854088232 1.60937120835346 0.509803921568627 16.3 16 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.04699358736294e-13 3.38607244276698e-12 1.60747246931576 0.50920245398773 16.3 16 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.47891731851915e-05 8.8424342195494e-05 1.60712033953058 0.509090909090909 16.3 16 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.97543110116399e-14 1.61629670198753e-12 1.60644108325859 0.50887573964497 16.3 16 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.15178247512841e-15 1.90580208455088e-13 1.60429752862977 0.508196721311475 16.3 16 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.07796965964502e-10 4.21149117853353e-09 1.5914665699897 0.504132231404959 16.3 16 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.07796965964502e-10 4.21149117853353e-09 1.5914665699897 0.504132231404959 16.3 16 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 6.09187775003054e-11 1.08359275478668e-09 1.59047078312323 0.50381679389313 16.3 16 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 6.09187775003054e-11 1.08359275478668e-09 1.59047078312323 0.50381679389313 16.3 16 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.62867230264274e-06 1.17050539730334e-05 1.57842176203897 0.5 16.3 16 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000651400734527872 0.00232900312872654 1.57842176203897 0.5 16.3 16 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00256802094188076 0.00808472079711576 1.57842176203897 0.5 16.3 16 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00256802094188076 0.00808472079711576 1.57842176203897 0.5 16.3 16 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0150231890573886 0.0364190767098194 1.57842176203897 0.5 16.3 16 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0150231890573886 0.0364190767098194 1.57842176203897 0.5 16.3 16 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0150231890573886 0.0364190767098194 1.57842176203897 0.5 16.3 16 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0150231890573886 0.0364190767098194 1.57842176203897 0.5 16.3 16 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0313558821548234 0.0701563212363422 1.57842176203897 0.5 16.3 16 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0313558821548234 0.0701563212363422 1.57842176203897 0.5 16.3 16 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0313558821548234 0.0701563212363422 1.57842176203897 0.5 16.3 16 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0313558821548234 0.0701563212363422 1.57842176203897 0.5 16.3 16 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0313558821548234 0.0701563212363422 1.57842176203897 0.5 16.3 16 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0313558821548234 0.0701563212363422 1.57842176203897 0.5 16.3 16 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0457900884012556 0.0954016043850464 1.57842176203897 0.5 16.3 16 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0457900884012556 0.0954016043850464 1.57842176203897 0.5 16.3 16 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0457900884012556 0.0954016043850464 1.57842176203897 0.5 16.3 16 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0457900884012556 0.0954016043850464 1.57842176203897 0.5 16.3 16 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0457900884012556 0.0954016043850464 1.57842176203897 0.5 16.3 16 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0457900884012556 0.0954016043850464 1.57842176203897 0.5 16.3 16 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0457900884012556 0.0954016043850464 1.57842176203897 0.5 16.3 16 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0457900884012556 0.0954016043850464 1.57842176203897 0.5 16.3 16 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.32519804484026e-08 2.36339772700549e-07 1.57842176203897 0.5 16.3 16 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.17604187754332e-05 7.21339479200064e-05 1.57842176203897 0.5 16.3 16 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.17866155829944e-05 0.000175319201451942 1.57842176203897 0.5 16.3 16 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 3.17866155829944e-05 0.000175319201451942 1.57842176203897 0.5 16.3 16 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000120666083380976 0.000552115230389483 1.57842176203897 0.5 16.3 16 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000236161964094174 0.000971267268514477 1.57842176203897 0.5 16.3 16 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000463963601047786 0.00170599535992506 1.57842176203897 0.5 16.3 16 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000463963601047786 0.00170599535992506 1.57842176203897 0.5 16.3 16 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000915734710339408 0.00317053647886369 1.57842176203897 0.5 16.3 16 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00363533838359305 0.010822356736094 1.57842176203897 0.5 16.3 16 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00363533838359305 0.010822356736094 1.57842176203897 0.5 16.3 16 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00363533838359305 0.010822356736094 1.57842176203897 0.5 16.3 16 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00363533838359305 0.010822356736094 1.57842176203897 0.5 16.3 16 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00363533838359305 0.010822356736094 1.57842176203897 0.5 16.3 16 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00734085177906009 0.0204423328407094 1.57842176203897 0.5 16.3 16 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00734085177906009 0.0204423328407094 1.57842176203897 0.5 16.3 16 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0104807787764568 0.0271660258632022 1.57842176203897 0.5 16.3 16 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0104807787764568 0.0271660258632022 1.57842176203897 0.5 16.3 16 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0104807787764568 0.0271660258632022 1.57842176203897 0.5 16.3 16 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0104807787764568 0.0271660258632022 1.57842176203897 0.5 16.3 16 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0104807787764568 0.0271660258632022 1.57842176203897 0.5 16.3 16 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0216386714526401 0.0506444563768205 1.57842176203897 0.5 16.3 16 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0216386714526401 0.0506444563768205 1.57842176203897 0.5 16.3 16 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0216386714526401 0.0506444563768205 1.57842176203897 0.5 16.3 16 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0675630365161537 0.131341804593561 1.57842176203897 0.5 16.3 16 3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.0675630365161537 0.131341804593561 1.57842176203897 0.5 16.3 16 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0675630365161537 0.131341804593561 1.57842176203897 0.5 16.3 16 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0675630365161537 0.131341804593561 1.57842176203897 0.5 16.3 16 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0675630365161537 0.131341804593561 1.57842176203897 0.5 16.3 16 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0675630365161537 0.131341804593561 1.57842176203897 0.5 16.3 16 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0675630365161537 0.131341804593561 1.57842176203897 0.5 16.3 16 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0675630365161537 0.131341804593561 1.57842176203897 0.5 16.3 16 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.11330036309912e-12 4.62650217952315e-11 1.56849458114564 0.49685534591195 16.3 16 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.42956774050687e-62 4.88027489474128e-59 1.56413740220151 0.495475113122172 16.3 16 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 9.23919652180431e-07 6.99328545240826e-06 1.55844173973468 0.493670886075949 16.3 16 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.43201558057376e-06 2.35930346432679e-05 1.55619046961588 0.492957746478873 16.3 16 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 8.09812178896125e-11 1.21301340059914e-09 1.55587287972412 0.492857142857143 16.3 16 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.7682529476284e-06 3.21574594524891e-05 1.55554608432826 0.492753623188406 16.3 16 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.7682529476284e-06 3.21574594524891e-05 1.55554608432826 0.492753623188406 16.3 16 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.28152582881781e-05 7.76004789109679e-05 1.55336744835581 0.492063492063492 16.3 16 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 1.78319426344173e-05 0.000104423269007308 1.55254599544816 0.491803278688525 16.3 16 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.62311400402405e-13 9.72771929759664e-12 1.55166885081797 0.491525423728814 16.3 16 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 2.48236024997727e-05 0.000140733013375205 1.55166885081797 0.491525423728814 16.3 16 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 7.55758676213043e-09 8.53527457342191e-08 1.55023565914541 0.491071428571429 16.3 16 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 4.81770064665899e-05 0.000246603885618552 1.54972318454735 0.490909090909091 16.3 16 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.81770064665899e-05 0.000246603885618552 1.54972318454735 0.490909090909091 16.3 16 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 4.81770064665899e-05 0.000246603885618552 1.54972318454735 0.490909090909091 16.3 16 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 4.81770064665899e-05 0.000246603885618552 1.54972318454735 0.490909090909091 16.3 16 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 4.81770064665899e-05 0.000246603885618552 1.54972318454735 0.490909090909091 16.3 16 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 4.81770064665899e-05 0.000246603885618552 1.54972318454735 0.490909090909091 16.3 16 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 9.14964341830842e-12 1.91469743886072e-10 1.54826083664969 0.490445859872611 16.3 16 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.3099883740733e-08 5.03740897087087e-07 1.54685332679819 0.49 16.3 16 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.0001827520156393 0.000773976542424774 1.54483832029346 0.48936170212766 16.3 16 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.42576994203212e-10 5.941387384445e-09 1.54281826364711 0.488721804511278 16.3 16 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000357501223586677 0.00136224983768062 1.54171427920085 0.488372093023256 16.3 16 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.4037134252085e-19 2.84910835533629e-17 1.5385338474748 0.487364620938628 16.3 16 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 3.70086031132679e-06 2.51977235551101e-05 1.53576171441629 0.486486486486487 16.3 16 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 3.70086031132679e-06 2.51977235551101e-05 1.53576171441629 0.486486486486487 16.3 16 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00138436254930739 0.00457064479736525 1.53332399740928 0.485714285714286 16.3 16 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00138436254930739 0.00457064479736525 1.53332399740928 0.485714285714286 16.3 16 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00138436254930739 0.00457064479736525 1.53332399740928 0.485714285714286 16.3 16 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 9.18783118845031e-18 6.22584941960228e-16 1.52985493859161 0.484615384615385 16.3 16 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.72858849368903e-13 5.23357750323295e-12 1.52909608197525 0.484375 16.3 16 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.91468216867591e-05 0.000111663636312534 1.52909608197525 0.484375 16.3 16 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.70440001773803e-05 0.000198919291518536 1.52580770330433 0.483333333333333 16.3 16 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 5.15595345529439e-05 0.000262032920245854 1.52399342541693 0.482758620689655 16.3 16 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 5.15595345529439e-05 0.000262032920245854 1.52399342541693 0.482758620689655 16.3 16 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00387597805841835 0.0113956958205151 1.52399342541693 0.482758620689655 16.3 16 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 5.0965900188405e-10 6.77798840823368e-09 1.52164400081454 0.482014388489209 16.3 16 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 5.73670501706384e-15 2.55104101227558e-13 1.52102460705573 0.481818181818182 16.3 16 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.19043885450475e-31 2.41999212851465e-29 1.52067462440339 0.481707317073171 16.3 16 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00548292432015224 0.0158259661411291 1.51996169677826 0.481481481481481 16.3 16 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00548292432015224 0.0158259661411291 1.51996169677826 0.481481481481481 16.3 16 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000139435594835885 0.000629894766512583 1.51771323272977 0.480769230769231 16.3 16 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 1.61531919728062e-07 1.38469832393393e-06 1.51528489155741 0.48 16.3 16 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000194482925700696 0.000820806891869944 1.51528489155741 0.48 16.3 16 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00777370624885621 0.0215213696344793 1.51528489155741 0.48 16.3 16 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00777370624885621 0.0215213696344793 1.51528489155741 0.48 16.3 16 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00777370624885621 0.0215213696344793 1.51528489155741 0.48 16.3 16 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000271434485856449 0.00109419624185192 1.51265418862068 0.479166666666667 16.3 16 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.05377934500479e-05 6.63507968115847e-05 1.51172788476971 0.47887323943662 16.3 16 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0110505402766642 0.0281808580890559 1.50979472890684 0.478260869565217 16.3 16 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0110505402766642 0.0281808580890559 1.50979472890684 0.478260869565217 16.3 16 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000529851170625922 0.00192341381581808 1.50667531830992 0.477272727272727 16.3 16 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000529851170625922 0.00192341381581808 1.50667531830992 0.477272727272727 16.3 16 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.71509081529086e-09 3.2742154492872e-08 1.50667531830992 0.477272727272727 16.3 16 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 5.4454927325691e-05 0.000274784970157654 1.50079446226656 0.475409836065574 16.3 16 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 8.00122170259632e-06 5.08291896553329e-05 1.49534693245797 0.473684210526316 16.3 16 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0225496808698957 0.0525175055284151 1.49534693245797 0.473684210526316 16.3 16 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0225496808698957 0.0525175055284151 1.49534693245797 0.473684210526316 16.3 16 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0225496808698957 0.0525175055284151 1.49534693245797 0.473684210526316 16.3 16 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00014651483583909 0.000659780415819701 1.49232602956411 0.472727272727273 16.3 16 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00204017048884697 0.00659809683097555 1.49073166414791 0.472222222222222 16.3 16 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000203957585266943 0.000846156396020001 1.48907713399902 0.471698113207547 16.3 16 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.97251299874034e-08 2.01934244403418e-07 1.48859288127252 0.471544715447154 16.3 16 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00286561776284094 0.0089424870099181 1.4855734230955 0.470588235294118 16.3 16 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00286561776284094 0.0089424870099181 1.4855734230955 0.470588235294118 16.3 16 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0324123730929083 0.0716454804866106 1.4855734230955 0.470588235294118 16.3 16 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0324123730929083 0.0716454804866106 1.4855734230955 0.470588235294118 16.3 16 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 4.0736526120954e-58 2.89840383350588e-55 1.4852016579746 0.47047047047047 16.3 16 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00039582530950009 0.00149405680482395 1.48178369497536 0.469387755102041 16.3 16 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.00039582530950009 0.00149405680482395 1.48178369497536 0.469387755102041 16.3 16 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.89100039344179e-05 0.000379354512157692 1.47658809997194 0.467741935483871 16.3 16 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.58517752522286e-07 2.1897069157096e-06 1.47516052527006 0.467289719626168 16.3 16 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00567683569830196 0.0162342585245216 1.4731936445697 0.466666666666667 16.3 16 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0468397390035655 0.0965984762348894 1.4731936445697 0.466666666666667 16.3 16 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0468397390035655 0.0965984762348894 1.4731936445697 0.466666666666667 16.3 16 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0468397390035655 0.0965984762348894 1.4731936445697 0.466666666666667 16.3 16 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0468397390035655 0.0965984762348894 1.4731936445697 0.466666666666667 16.3 16 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0468397390035655 0.0965984762348894 1.4731936445697 0.466666666666667 16.3 16 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.01554720424519e-30 3.58515458955114e-28 1.47201130617117 0.466292134831461 16.3 16 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000152102433327325 0.000661630439596989 1.4695650887949 0.46551724137931 16.3 16 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000152102433327325 0.000661630439596989 1.4695650887949 0.46551724137931 16.3 16 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000152102433327325 0.000661630439596989 1.4695650887949 0.46551724137931 16.3 16 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.61549388838154e-11 3.28406829023848e-10 1.46869190692396 0.46524064171123 16.3 16 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.94900574787767e-08 2.91419109668745e-07 1.46656510173699 0.464566929133858 16.3 16 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.94900574787767e-08 2.91419109668745e-07 1.46656510173699 0.464566929133858 16.3 16 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 6.18209022126267e-09 7.09444708456192e-08 1.46567735046475 0.464285714285714 16.3 16 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 6.26317420681296e-06 4.08830132857561e-05 1.46567735046475 0.464285714285714 16.3 16 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 6.26317420681296e-06 4.08830132857561e-05 1.46567735046475 0.464285714285714 16.3 16 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0080091739146542 0.0220081129404379 1.46567735046475 0.464285714285714 16.3 16 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 8.37246158125048e-14 2.90585678783401e-12 1.46325794249106 0.463519313304721 16.3 16 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 9.77037913614316e-10 1.27552747804878e-08 1.45854162821322 0.462025316455696 16.3 16 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.34282929932545e-09 1.73713281176374e-08 1.45700470342058 0.461538461538462 16.3 16 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00209904234666588 0.00675777660476368 1.45700470342058 0.461538461538462 16.3 16 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00209904234666588 0.00675777660476368 1.45700470342058 0.461538461538462 16.3 16 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.011320878704796 0.0287671614230799 1.45700470342058 0.461538461538462 16.3 16 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0681471643298848 0.131578581874391 1.45700470342058 0.461538461538462 16.3 16 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0681471643298848 0.131578581874391 1.45700470342058 0.461538461538462 16.3 16 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0681471643298848 0.131578581874391 1.45700470342058 0.461538461538462 16.3 16 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0681471643298848 0.131578581874391 1.45700470342058 0.461538461538462 16.3 16 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0681471643298848 0.131578581874391 1.45700470342058 0.461538461538462 16.3 16 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.53585492373112e-09 3.11079444523222e-08 1.45380951766747 0.460526315789474 16.3 16 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.20753074399726e-08 1.31169179290695e-07 1.45351068734523 0.460431654676259 16.3 16 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.33078223911987e-06 9.86303711597696e-06 1.45214802107585 0.46 16.3 16 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 6.45054203651351e-06 4.17232787179942e-05 1.45142230992089 0.459770114942529 16.3 16 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 6.45054203651351e-06 4.17232787179942e-05 1.45142230992089 0.459770114942529 16.3 16 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 4.35999930700069e-05 0.000228940185013357 1.44688661520239 0.458333333333333 16.3 16 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000789171743720062 0.00278533057055914 1.44688661520239 0.458333333333333 16.3 16 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 7.15224042949474e-24 7.26974152226501e-22 1.44393739666345 0.457399103139013 16.3 16 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 6.02594000320908e-05 0.000303000446097757 1.44312846814991 0.457142857142857 16.3 16 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00109819523912849 0.00369440147820294 1.44116769577471 0.456521739130435 16.3 16 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0227703523858292 0.0528584199755871 1.43492887458088 0.454545454545455 16.3 16 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0227703523858292 0.0528584199755871 1.43492887458088 0.454545454545455 16.3 16 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.100016139899557 0.181728790384651 1.43492887458088 0.454545454545455 16.3 16 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.100016139899557 0.181728790384651 1.43492887458088 0.454545454545455 16.3 16 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.100016139899557 0.181728790384651 1.43492887458088 0.454545454545455 16.3 16 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.100016139899557 0.181728790384651 1.43492887458088 0.454545454545455 16.3 16 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.100016139899557 0.181728790384651 1.43492887458088 0.454545454545455 16.3 16 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.100016139899557 0.181728790384651 1.43492887458088 0.454545454545455 16.3 16 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.74210613471065e-08 1.85001270872631e-07 1.43492887458088 0.454545454545455 16.3 16 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.27843708200664e-10 3.21011481950045e-09 1.43179241802442 0.453551912568306 16.3 16 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00809093718706536 0.0220563287685709 1.42567126893842 0.451612903225806 16.3 16 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.37401447486547e-05 0.000135128903909343 1.42442939501077 0.451219512195122 16.3 16 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0324242371281639 0.0716454804866106 1.42057958583507 0.45 16.3 16 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.41069549348785e-06 1.04011382758197e-05 1.4191314924754 0.44954128440367 16.3 16 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.26954310741268e-05 7.72034120447969e-05 1.41880607823727 0.449438202247191 16.3 16 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.000160804212486676 0.0006892301035197 1.41351202570654 0.447761194029851 16.3 16 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 6.19370721432637e-05 0.000309250714596015 1.41227210287697 0.447368421052632 16.3 16 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 6.32355988944511e-08 5.69520615359519e-07 1.41050455331142 0.446808510638298 16.3 16 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.95244041615551e-06 1.38916135609464e-05 1.40623029708926 0.445454545454545 16.3 16 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 7.65419048619825e-07 5.91951796840223e-06 1.40598913257252 0.445378151260504 16.3 16 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.83944292205055e-08 1.93890909487255e-07 1.40530453652501 0.445161290322581 16.3 16 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0463237203213241 0.0962316117040062 1.40304156625686 0.444444444444444 16.3 16 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0463237203213241 0.0962316117040062 1.40304156625686 0.444444444444444 16.3 16 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000161388044149952 0.000689655215691837 1.39803070352023 0.442857142857143 16.3 16 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.000222000463346866 0.000915671476355336 1.39272508415203 0.441176470588235 16.3 16 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00805509291361844 0.0220081129404379 1.39272508415203 0.441176470588235 16.3 16 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00805509291361844 0.0220081129404379 1.39272508415203 0.441176470588235 16.3 16 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00153579821642661 0.0050472075334297 1.38901115059429 0.44 16.3 16 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.44606534025551e-08 3.35873354738602e-07 1.3811190417841 0.4375 16.3 16 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0112491723598818 0.0286360863472482 1.3811190417841 0.4375 16.3 16 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0664405693209519 0.130767538234737 1.3811190417841 0.4375 16.3 16 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0664405693209519 0.130767538234737 1.3811190417841 0.4375 16.3 16 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0664405693209519 0.130767538234737 1.3811190417841 0.4375 16.3 16 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0664405693209519 0.130767538234737 1.3811190417841 0.4375 16.3 16 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0664405693209519 0.130767538234737 1.3811190417841 0.4375 16.3 16 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000116683094974117 0.000537346421191483 1.376059997675 0.435897435897436 16.3 16 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.2806377897324e-05 0.000180245080107691 1.37254066264258 0.434782608695652 16.3 16 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0317855924698021 0.0707838780665547 1.37254066264258 0.434782608695652 16.3 16 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0317855924698021 0.0707838780665547 1.37254066264258 0.434782608695652 16.3 16 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0157190001386735 0.0379764638324827 1.36796552710044 0.433333333333333 16.3 16 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.6620880651752e-33 1.58002521945738e-30 1.36621397072771 0.432778489116517 16.3 16 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.17234415156955e-07 1.02508876511953e-06 1.3645710716982 0.432258064516129 16.3 16 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000115520491526523 0.000533719673513774 1.36406818941639 0.432098765432099 16.3 16 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 6.11806117742554e-05 0.000306549332939315 1.36318243085183 0.431818181818182 16.3 16 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.000299302756849148 0.00117007643680313 1.35919651731133 0.430555555555556 16.3 16 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000299302756849148 0.00117007643680313 1.35919651731133 0.430555555555556 16.3 16 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.63976415042505e-11 6.81497945533532e-10 1.35293293889054 0.428571428571429 16.3 16 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.63976415042505e-11 6.81497945533532e-10 1.35293293889054 0.428571428571429 16.3 16 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.63976415042505e-11 6.81497945533532e-10 1.35293293889054 0.428571428571429 16.3 16 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0957406259611808 0.175792142893884 1.35293293889054 0.428571428571429 16.3 16 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0957406259611808 0.175792142893884 1.35293293889054 0.428571428571429 16.3 16 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0957406259611808 0.175792142893884 1.35293293889054 0.428571428571429 16.3 16 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0957406259611808 0.175792142893884 1.35293293889054 0.428571428571429 16.3 16 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0957406259611808 0.175792142893884 1.35293293889054 0.428571428571429 16.3 16 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0957406259611808 0.175792142893884 1.35293293889054 0.428571428571429 16.3 16 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 1.14586313189321e-07 1.01277219669816e-06 1.35293293889054 0.428571428571429 16.3 16 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000155263463620422 0.000671549874564925 1.34743321149668 0.426829268292683 16.3 16 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 1.52887649879032e-07 1.32658003523087e-06 1.34458150099616 0.425925925925926 16.3 16 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000401374834368671 0.0015109957389064 1.3405773869372 0.424657534246575 16.3 16 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0152896856696103 0.0370020794351282 1.33926694960882 0.424242424242424 16.3 16 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000152157606578055 0.000661630439596989 1.33701608078595 0.423529411764706 16.3 16 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000152157606578055 0.000661630439596989 1.33701608078595 0.423529411764706 16.3 16 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000152157606578055 0.000661630439596989 1.33701608078595 0.423529411764706 16.3 16 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000152157606578055 0.000661630439596989 1.33701608078595 0.423529411764706 16.3 16 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000152157606578055 0.000661630439596989 1.33701608078595 0.423529411764706 16.3 16 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0307461525924678 0.0694472621255265 1.3355876448022 0.423076923076923 16.3 16 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000206855224702599 0.000855683095208715 1.3311990764184 0.421686746987952 16.3 16 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0636139308314538 0.126251915722676 1.32919727329597 0.421052631578947 16.3 16 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0636139308314538 0.126251915722676 1.32919727329597 0.421052631578947 16.3 16 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00074547986396282 0.0026388503642266 1.32678930722116 0.420289855072464 16.3 16 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000281020848924552 0.00112201244712389 1.32509481257592 0.419753086419753 16.3 16 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000281020848924552 0.00112201244712389 1.32509481257592 0.419753086419753 16.3 16 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0212281567148349 0.0500126937172351 1.32383760687139 0.419354838709677 16.3 16 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.000201596011662229 0.000838804457881146 1.32146938217216 0.418604651162791 16.3 16 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.30122558934101e-09 5.01692132264939e-08 1.31653115578138 0.417040358744395 16.3 16 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.138749033826914 0.238742291578838 1.3153514683658 0.416666666666667 16.3 16 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 3.78903192951037e-08 3.66788601067568e-07 1.31401608616442 0.416243654822335 16.3 16 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00138040414285752 0.00457064479736525 1.31130423307853 0.415384615384615 16.3 16 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 8.62250497224723e-07 6.56140351631434e-06 1.31038787791914 0.415094339622642 16.3 16 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 8.62250497224723e-07 6.56140351631434e-06 1.31038787791914 0.415094339622642 16.3 16 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00373351534685765 0.0110914245064268 1.31038787791914 0.415094339622642 16.3 16 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0103094794426846 0.0269676272921695 1.30893511973963 0.414634146341463 16.3 16 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 6.89032207704763e-14 2.4512320789097e-12 1.30831750329433 0.414438502673797 16.3 16 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.93273812202533e-08 2.01934244403418e-07 1.30783517426086 0.414285714285714 16.3 16 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0294674860627683 0.0667710711263046 1.3062800789288 0.413793103448276 16.3 16 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0294674860627683 0.0667710711263046 1.3062800789288 0.413793103448276 16.3 16 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 1.55747808400075e-06 1.13655964796568e-05 1.30347087445798 0.412903225806452 16.3 16 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000358033337521118 0.00136224983768062 1.29987674520856 0.411764705882353 16.3 16 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000358033337521118 0.00136224983768062 1.29987674520856 0.411764705882353 16.3 16 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00509378618521628 0.0147626430581726 1.29987674520856 0.411764705882353 16.3 16 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0902603066805824 0.171482531917849 1.29987674520856 0.411764705882353 16.3 16 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00244538532051523 0.00773285180242928 1.28246768165666 0.40625 16.3 16 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 2.06156955375141e-05 0.000119252580284075 1.26273740963117 0.4 16.3 16 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0184263480941858 0.0438473132742917 1.26273740963117 0.4 16.3 16 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0844070599669805 0.16100703261798 1.26273740963117 0.4 16.3 16 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0844070599669805 0.16100703261798 1.26273740963117 0.4 16.3 16 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.128341217266258 0.221369154145315 1.26273740963117 0.4 16.3 16 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.128341217266258 0.221369154145315 1.26273740963117 0.4 16.3 16 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.128341217266258 0.221369154145315 1.26273740963117 0.4 16.3 16 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.128341217266258 0.221369154145315 1.26273740963117 0.4 16.3 16 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00202783031873658 0.00657312652292063 1.24612244371497 0.394736842105263 16.3 16 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 3.32644851518227e-05 0.000182059086042476 1.24495237569271 0.394366197183099 16.3 16 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 4.62648549881125e-05 0.000242040031794427 1.24430328686283 0.394160583941606 16.3 16 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0363539110212699 0.0789795654706368 1.24360502463676 0.393939393939394 16.3 16 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0531275629181368 0.108777729543178 1.24018852731633 0.392857142857143 16.3 16 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0531275629181368 0.108777729543178 1.24018852731633 0.392857142857143 16.3 16 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.00033905100186463 0.0013004570772328 1.23913484122685 0.392523364485981 16.3 16 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0164550297055367 0.0392219552277701 1.23528659637832 0.391304347826087 16.3 16 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.2686594762724e-17 8.20592015788921e-16 1.23229817191845 0.390357698289269 16.3 16 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 7.71733441087867e-05 0.000374804329920831 1.23024049100096 0.389705882352941 16.3 16 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00123317364650442 0.00410961615685198 1.22766137047475 0.388888888888889 16.3 16 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.0341084708310173 0.074442260724751 1.22766137047475 0.388888888888889 16.3 16 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.118219952545565 0.211075272863662 1.22766137047475 0.388888888888889 16.3 16 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.118219952545565 0.211075272863662 1.22766137047475 0.388888888888889 16.3 16 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0496257664806541 0.102048360840998 1.22200394480436 0.387096774193548 16.3 16 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 9.66751289111152e-05 0.000451044945706613 1.22126063340241 0.386861313868613 16.3 16 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0729325520576984 0.140437106330318 1.21417058618382 0.384615384615385 16.3 16 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.182875202262558 0.298430519288555 1.21417058618382 0.384615384615385 16.3 16 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.182875202262558 0.298430519288555 1.21417058618382 0.384615384615385 16.3 16 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.182875202262558 0.298430519288555 1.21417058618382 0.384615384615385 16.3 16 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.182875202262558 0.298430519288555 1.21417058618382 0.384615384615385 16.3 16 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.182875202262558 0.298430519288555 1.21417058618382 0.384615384615385 16.3 16 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.182875202262558 0.298430519288555 1.21417058618382 0.384615384615385 16.3 16 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0298437448484902 0.0675161350069976 1.20260705679159 0.380952380952381 16.3 16 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.59302876208136e-05 9.36727243157759e-05 1.20097307981226 0.380434782608696 16.3 16 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 4.26086942726828e-07 3.48460758333492e-06 1.20083851700219 0.380392156862745 16.3 16 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.0886815600309e-05 6.79470991194725e-05 1.2002582148838 0.380208333333333 16.3 16 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.66998704400405e-12 5.67073367704145e-11 1.19896279298313 0.37979797979798 16.3 16 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.00108176105403701 0.00364773928884993 1.1874365549284 0.376146788990826 16.3 16 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 8.44079371597984e-34 2.40224989156786e-31 1.18407107003827 0.375080697224015 16.3 16 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0259768614413667 0.059717405219814 1.18381632152922 0.375 16.3 16 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0998889193041232 0.181728790384651 1.18381632152922 0.375 16.3 16 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0998889193041232 0.181728790384651 1.18381632152922 0.375 16.3 16 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0158951515968462 0.0383369503768002 1.17712809372397 0.372881355932203 16.3 16 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00079077550984251 0.00278533057055914 1.17108711377085 0.370967741935484 16.3 16 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00611615023935598 0.0171662362733798 1.16920130521405 0.37037037037037 16.3 16 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0917810218100572 0.173676055898552 1.16920130521405 0.37037037037037 16.3 16 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0917810218100572 0.173676055898552 1.16920130521405 0.37037037037037 16.3 16 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0917810218100572 0.173676055898552 1.16920130521405 0.37037037037037 16.3 16 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0345408828934252 0.075155468436306 1.16665956324619 0.369565217391304 16.3 16 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0345408828934252 0.075155468436306 1.16665956324619 0.369565217391304 16.3 16 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00102773755400984 0.00351555418114423 1.16440949658612 0.368852459016393 16.3 16 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000179870168982027 0.000764045523765445 1.16202829107163 0.368098159509202 16.3 16 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0320626351196929 0.0712892652739421 1.15965680476332 0.36734693877551 16.3 16 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0843489677065987 0.16100703261798 1.15750929216191 0.366666666666667 16.3 16 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0495038328961174 0.10194494097131 1.15494275271144 0.365853658536585 16.3 16 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00161351534413631 0.00527823525219762 1.1479430996647 0.363636363636364 16.3 16 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0276071127553407 0.0633627765336287 1.1479430996647 0.363636363636364 16.3 16 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0775470027354804 0.148718847564136 1.1479430996647 0.363636363636364 16.3 16 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0775470027354804 0.148718847564136 1.1479430996647 0.363636363636364 16.3 16 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.136384780014408 0.234958283245161 1.1479430996647 0.363636363636364 16.3 16 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.000385943760121197 0.0014645279217399 1.14611516479262 0.363057324840764 16.3 16 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0713251221898198 0.137527979506929 1.1399712725837 0.361111111111111 16.3 16 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.124178741149157 0.217953923734398 1.13646366866806 0.36 16.3 16 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.124178741149157 0.217953923734398 1.13646366866806 0.36 16.3 16 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0656337985722087 0.130079241459962 1.13322588043823 0.358974358974359 16.3 16 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.113255165638902 0.203230896222141 1.12744411574212 0.357142857142857 16.3 16 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.231283300207767 0.362446763585359 1.12744411574212 0.357142857142857 16.3 16 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.231283300207767 0.362446763585359 1.12744411574212 0.357142857142857 16.3 16 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.51929009113347e-10 4.76947599969802e-09 1.12231039472473 0.355516637478109 16.3 16 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00875012520820674 0.023015578874821 1.12017028273733 0.354838709677419 16.3 16 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000502996868124256 0.00184001167953937 1.11957822656252 0.354651162790698 16.3 16 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0946133609304508 0.175077779719157 1.11418006732162 0.352941176470588 16.3 16 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.206511405680455 0.329445885967811 1.11418006732162 0.352941176470588 16.3 16 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.206511405680455 0.329445885967811 1.11418006732162 0.352941176470588 16.3 16 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.206511405680455 0.329445885967811 1.11418006732162 0.352941176470588 16.3 16 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.206511405680455 0.329445885967811 1.11418006732162 0.352941176470588 16.3 16 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.206511405680455 0.329445885967811 1.11418006732162 0.352941176470588 16.3 16 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.206511405680455 0.329445885967811 1.11418006732162 0.352941176470588 16.3 16 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00653193098890834 0.0182971216480641 1.11241152753222 0.352380952380952 16.3 16 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0866371253050849 0.165039664403127 1.10916123818954 0.351351351351351 16.3 16 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0794180058514961 0.152102048891896 1.10489523342728 0.35 16.3 16 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.185432298805672 0.301221645206017 1.10489523342728 0.35 16.3 16 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.185432298805672 0.301221645206017 1.10489523342728 0.35 16.3 16 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.185432298805672 0.301221645206017 1.10489523342728 0.35 16.3 16 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.185432298805672 0.301221645206017 1.10489523342728 0.35 16.3 16 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.056571282105236 0.115662262120332 1.09275352756544 0.346153846153846 16.3 16 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00849277708040594 0.022380040343366 1.09054594468147 0.345454545454545 16.3 16 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0441842549531 0.0945476613507689 1.08678219681371 0.344262295081967 16.3 16 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.040735556982074 0.088363868270566 1.08516496140179 0.34375 16.3 16 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.113775579225047 0.203907618686703 1.08234635111243 0.342857142857143 16.3 16 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0215883488702126 0.0506444563768205 1.07619665593566 0.340909090909091 16.3 16 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0670473217395852 0.131341804593561 1.0721355364793 0.339622641509434 16.3 16 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0521309534673625 0.107045233454627 1.06925345170382 0.338709677419355 16.3 16 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0937779667486234 0.173803962845618 1.05228117469264 0.333333333333333 16.3 16 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.181073103920748 0.297536982539521 1.05228117469264 0.333333333333333 16.3 16 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.200885480146347 0.324472234106983 1.05228117469264 0.333333333333333 16.3 16 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.200885480146347 0.324472234106983 1.05228117469264 0.333333333333333 16.3 16 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.200885480146347 0.324472234106983 1.05228117469264 0.333333333333333 16.3 16 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.200885480146347 0.324472234106983 1.05228117469264 0.333333333333333 16.3 16 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.223796502145931 0.352595497860939 1.05228117469264 0.333333333333333 16.3 16 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.223796502145931 0.352595497860939 1.05228117469264 0.333333333333333 16.3 16 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.2506571322479 0.379048989573605 1.05228117469264 0.333333333333333 16.3 16 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.148515830414713 0.248640523037877 1.05228117469264 0.333333333333333 16.3 16 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.163762475287717 0.269715280479655 1.05228117469264 0.333333333333333 16.3 16 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.163762475287717 0.269715280479655 1.05228117469264 0.333333333333333 16.3 16 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.282754341678522 0.419999403140435 1.05228117469264 0.333333333333333 16.3 16 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.282754341678522 0.419999403140435 1.05228117469264 0.333333333333333 16.3 16 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.282754341678522 0.419999403140435 1.05228117469264 0.333333333333333 16.3 16 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0314103012771891 0.0701677530886029 1.04108669411081 0.329787234042553 16.3 16 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.158215375312697 0.261791254732522 1.02384114294419 0.324324324324324 16.3 16 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.192484259529074 0.312320526008976 1.0183366206703 0.32258064516129 16.3 16 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.213197390475307 0.339351103631277 1.01469970416791 0.321428571428571 16.3 16 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.126552373453829 0.219347171041168 1.01018992770494 0.32 16.3 16 3 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.264588639140641 0.394664186055694 1.00445021220661 0.318181818181818 16.3 16 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.264588639140641 0.394664186055694 1.00445021220661 0.318181818181818 16.3 16 3 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.264588639140641 0.394664186055694 1.00445021220661 0.318181818181818 16.3 16 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.297080363187486 0.440042281858769 0.996897954971978 0.315789473684211 16.3 16 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.158846325979856 0.262225431402941 0.986513601274354 0.3125 16.3 16 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.158846325979856 0.262225431402941 0.986513601274354 0.3125 16.3 16 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.223222761805182 0.352595497860939 0.986513601274354 0.3125 16.3 16 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.336060130608104 0.486483790290267 0.986513601274354 0.3125 16.3 16 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.336060130608104 0.486483790290267 0.986513601274354 0.3125 16.3 16 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.336060130608104 0.486483790290267 0.986513601274354 0.3125 16.3 16 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.336060130608104 0.486483790290267 0.986513601274354 0.3125 16.3 16 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.336060130608104 0.486483790290267 0.986513601274354 0.3125 16.3 16 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.336060130608104 0.486483790290267 0.986513601274354 0.3125 16.3 16 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.336060130608104 0.486483790290267 0.986513601274354 0.3125 16.3 16 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.174090294710459 0.286393629332928 0.982129096379801 0.311111111111111 16.3 16 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.125595374182858 0.217953923734398 0.96459107680159 0.305555555555556 16.3 16 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.231527834222833 0.362446763585359 0.96459107680159 0.305555555555556 16.3 16 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0897108716944081 0.17066653799618 0.963668023139579 0.305263157894737 16.3 16 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.307187436323469 0.451578225091216 0.960778463849805 0.304347826086957 16.3 16 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.307187436323469 0.451578225091216 0.960778463849805 0.304347826086957 16.3 16 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.307187436323469 0.451578225091216 0.960778463849805 0.304347826086957 16.3 16 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.119530423485361 0.213147609799084 0.959041070605954 0.30379746835443 16.3 16 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.255704036322777 0.385452164922999 0.956619249720585 0.303030303030303 16.3 16 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.344929533636836 0.494695885384575 0.94705305722338 0.3 16.3 16 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.344929533636836 0.494695885384575 0.94705305722338 0.3 16.3 16 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.076591504773301 0.147283393638388 0.944567353661113 0.299212598425197 16.3 16 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.223065090671599 0.352595497860939 0.940336368874278 0.297872340425532 16.3 16 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.209094708663814 0.333193471924533 0.935361044171239 0.296296296296296 16.3 16 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.314633381283667 0.462046750842784 0.935361044171239 0.296296296296296 16.3 16 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.390038765994625 0.544142317657207 0.928483389434686 0.294117647058824 16.3 16 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.390038765994625 0.544142317657207 0.928483389434686 0.294117647058824 16.3 16 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.390038765994625 0.544142317657207 0.928483389434686 0.294117647058824 16.3 16 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.390038765994625 0.544142317657207 0.928483389434686 0.294117647058824 16.3 16 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.390038765994625 0.544142317657207 0.928483389434686 0.294117647058824 16.3 16 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0324108204534344 0.0716454804866106 0.925500310271843 0.293172690763052 16.3 16 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.268228273073606 0.399674170244755 0.923954202169151 0.292682926829268 16.3 16 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.35095883004346 0.498915499652191 0.920746027856064 0.291666666666667 16.3 16 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.35095883004346 0.498915499652191 0.920746027856064 0.291666666666667 16.3 16 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.32028357965225 0.468892524532049 0.91650295860327 0.290322580645161 16.3 16 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.32028357965225 0.468892524532049 0.91650295860327 0.290322580645161 16.3 16 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.151714376628334 0.253689257276287 0.910627939637865 0.288461538461538 16.3 16 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.299082009567604 0.441029740533368 0.901955292593695 0.285714285714286 16.3 16 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.393382746233199 0.547198091778927 0.901955292593695 0.285714285714286 16.3 16 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.393382746233199 0.547198091778927 0.901955292593695 0.285714285714286 16.3 16 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.393382746233199 0.547198091778927 0.901955292593695 0.285714285714286 16.3 16 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.358263899679364 0.508791945353029 0.887862241146918 0.28125 16.3 16 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.114938422100048 0.205732546727508 0.887328990551635 0.281081081081081 16.3 16 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.395282853749062 0.549202959817432 0.883916186741821 0.28 16.3 16 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.251360953178339 0.379307143555437 0.879120981388791 0.278481012658228 16.3 16 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.251360953178339 0.379307143555437 0.879120981388791 0.278481012658228 16.3 16 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.443647086666441 0.583762827149536 0.876900978910537 0.277777777777778 16.3 16 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.443647086666441 0.583762827149536 0.876900978910537 0.277777777777778 16.3 16 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.443647086666441 0.583762827149536 0.876900978910537 0.277777777777778 16.3 16 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.39629450109658 0.549202959817432 0.870853385952533 0.275862068965517 16.3 16 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.39629450109658 0.549202959817432 0.870853385952533 0.275862068965517 16.3 16 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.441680536392908 0.583762827149536 0.860957324748527 0.272727272727273 16.3 16 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.396723848438084 0.549202959817432 0.860957324748527 0.272727272727273 16.3 16 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.396753789664315 0.549202959817432 0.853200952453495 0.27027027027027 16.3 16 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.000877279437813158 0.00305972705884344 0.8515777896659 0.269756097560976 16.3 16 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.439575496689184 0.583762827149536 0.849919410328674 0.269230769230769 16.3 16 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.227184160438949 0.356824569872654 0.846958018655055 0.268292682926829 16.3 16 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.43742684650283 0.583762827149536 0.841824939754115 0.266666666666667 16.3 16 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.431068102781151 0.583089268305682 0.82679235154422 0.261904761904762 16.3 16 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.317839585939778 0.466273949270417 0.804685604176728 0.254901960784314 16.3 16 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.494578030590428 0.645673887642366 0.789210881019483 0.25 16.3 16 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.535211975796969 0.685514528856064 0.789210881019483 0.25 16.3 16 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.546346615523431 0.699146793066404 0.789210881019483 0.25 16.3 16 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.485977139948638 0.635027979932886 0.779926047125136 0.247058823529412 16.3 16 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.485977139948638 0.635027979932886 0.779926047125136 0.247058823529412 16.3 16 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.510455637636756 0.665181659667677 0.776272997724082 0.245901639344262 16.3 16 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.515474548220398 0.668051258759223 0.775365076089317 0.245614035087719 16.3 16 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.521568852066072 0.675334373512303 0.765295399776468 0.242424242424242 16.3 16 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.556995554540491 0.703387891995049 0.765295399776468 0.242424242424242 16.3 16 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.579400119601571 0.722853035008899 0.757642445778704 0.24 16.3 16 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.554673168102784 0.703387891995049 0.755863942384857 0.23943661971831 16.3 16 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.566851038592445 0.708812854057161 0.751629410494746 0.238095238095238 16.3 16 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.594147824676629 0.739420898323328 0.751629410494746 0.238095238095238 16.3 16 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.594147824676629 0.739420898323328 0.751629410494746 0.238095238095238 16.3 16 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.570879017754176 0.713222864147667 0.748529907771056 0.237113402061856 16.3 16 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.594446597106035 0.739420898323328 0.742786711547749 0.235294117647059 16.3 16 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.618047178106577 0.762115367803864 0.728502351710292 0.230769230769231 16.3 16 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.65762378146243 0.803467242444386 0.708679158466474 0.224489795918367 16.3 16 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.660788154873623 0.803467242444386 0.701520783128429 0.222222222222222 16.3 16 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.660788154873623 0.803467242444386 0.701520783128429 0.222222222222222 16.3 16 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.743302575109648 0.868931824621555 0.64993837260428 0.205882352941176 16.3 16 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.762715353302731 0.88599505938758 0.631368704815586 0.2 16.3 16 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.958620783676439 1 0.61100197240218 0.193548387096774 16.3 16 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.989186425029729 1 0.610214598726404 0.193298969072165 16.3 16 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.852973271893734 0.959510644984018 0.59563085359961 0.188679245283019 16.3 16 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.878196092072538 0.98279327654101 0.594767620478451 0.188405797101449 16.3 16 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.842457756443087 0.949934538366491 0.581523807066987 0.184210526315789 16.3 16 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.838783082296319 0.947292322307668 0.563722057871059 0.178571428571429 16.3 16 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.99507732779324 1 0.563722057871059 0.178571428571429 16.3 16 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.879195952942168 0.98279327654101 0.541173175556217 0.171428571428571 16.3 16 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.879195952942168 0.98279327654101 0.541173175556217 0.171428571428571 16.3 16 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.994454275009466 1 0.526140587346322 0.166666666666667 16.3 16 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.898055140848848 0.995274505784978 0.50916831033515 0.161290322580645 16.3 16 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.913090823081576 1 0.493256800637177 0.15625 16.3 16 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.458550738594024 0.145256087321578 16.3 16 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999906927078088 1 0.412542051442002 0.130681818181818 16.3 16 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.385329001582749 0.122061482820976 16.3 16 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.987405236099386 1 0.367074828381155 0.116279069767442 16.3 16 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.99518255453986 1 0.328837867091451 0.104166666666667 16.3 16 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999994334614902 1 0.263070293673161 0.0833333333333333 16.3 16 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 1.44841756916449e-06 6.04427624903538e-06 1.31642198702629 1 17.3 17 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 1.80324660902132e-05 6.57953826830088e-05 1.31642198702629 1 17.3 17 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 9.68452477103207e-05 0.000304218073933303 1.31642198702629 1 17.3 17 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 9.68452477103207e-05 0.000304218073933303 1.31642198702629 1 17.3 17 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 9.68452477103207e-05 0.000304218073933303 1.31642198702629 1 17.3 17 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 9.68452477103207e-05 0.000304218073933303 1.31642198702629 1 17.3 17 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 9.68452477103207e-05 0.000304218073933303 1.31642198702629 1 17.3 17 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00120499869822733 0.00299775025800261 1.31642198702629 1 17.3 17 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 7.49028173041937e-10 5.60982679072987e-09 1.31642198702629 1 17.3 17 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 6.24893848628855e-07 2.76156505154926e-06 1.31642198702629 1 17.3 17 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 3.35710125446333e-06 1.35714633099469e-05 1.31642198702629 1 17.3 17 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 3.35710125446333e-06 1.35714633099469e-05 1.31642198702629 1 17.3 17 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 7.7806919239185e-06 3.01687319011881e-05 1.31642198702629 1 17.3 17 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 7.7806919239185e-06 3.01687319011881e-05 1.31642198702629 1 17.3 17 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 4.17902678911578e-05 0.00014025365851207 1.31642198702629 1 17.3 17 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 4.17902678911578e-05 0.00014025365851207 1.31642198702629 1 17.3 17 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 4.17902678911578e-05 0.00014025365851207 1.31642198702629 1 17.3 17 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 4.17902678911578e-05 0.00014025365851207 1.31642198702629 1 17.3 17 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 4.17902678911578e-05 0.00014025365851207 1.31642198702629 1 17.3 17 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 4.17902678911578e-05 0.00014025365851207 1.31642198702629 1 17.3 17 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.000224421573682802 0.000655753386756936 1.31642198702629 1 17.3 17 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000224421573682802 0.000655753386756936 1.31642198702629 1 17.3 17 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000224421573682802 0.000655753386756936 1.31642198702629 1 17.3 17 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000224421573682802 0.000655753386756936 1.31642198702629 1 17.3 17 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000224421573682802 0.000655753386756936 1.31642198702629 1 17.3 17 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.000224421573682802 0.000655753386756936 1.31642198702629 1 17.3 17 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000520036736229315 0.00141493742954936 1.31642198702629 1 17.3 17 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000520036736229315 0.00141493742954936 1.31642198702629 1 17.3 17 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.000520036736229315 0.00141493742954936 1.31642198702629 1 17.3 17 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.000520036736229315 0.00141493742954936 1.31642198702629 1 17.3 17 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.000520036736229315 0.00141493742954936 1.31642198702629 1 17.3 17 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000520036736229315 0.00141493742954936 1.31642198702629 1 17.3 17 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.000520036736229315 0.00141493742954936 1.31642198702629 1 17.3 17 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00279204405299743 0.00627658560413166 1.31642198702629 1 17.3 17 3 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00646905869182094 0.0133425240086353 1.31642198702629 1 17.3 17 3 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.014987978262833 0.0275910647710366 1.31642198702629 1 17.3 17 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 3.48111226355173e-12 3.60967778801236e-11 1.27985470960889 0.972222222222222 17.3 17 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 2.54404209438434e-08 1.38647252317396e-07 1.26376510754524 0.96 17.3 17 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 5.99155158049684e-15 9.91392778958954e-14 1.26157107090019 0.958333333333333 17.3 17 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 5.66920036987394e-08 2.92292468345312e-07 1.26157107090019 0.958333333333333 17.3 17 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 5.66920036987394e-08 2.92292468345312e-07 1.26157107090019 0.958333333333333 17.3 17 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.26122749424629e-07 6.14632439833039e-07 1.25918624845993 0.956521739130435 17.3 17 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.26122749424629e-07 6.14632439833039e-07 1.25918624845993 0.956521739130435 17.3 17 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 3.23726214891005e-13 4.51629807637157e-12 1.25519305739716 0.953488372093023 17.3 17 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 6.20735838385451e-07 2.75173550785824e-06 1.25373522573932 0.952380952380952 17.3 17 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 6.20735838385451e-07 2.75173550785824e-06 1.25373522573932 0.952380952380952 17.3 17 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 6.20735838385451e-07 2.75173550785824e-06 1.25373522573932 0.952380952380952 17.3 17 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 3.50060108746104e-12 3.60967778801236e-11 1.25060088767497 0.95 17.3 17 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 1.37277823629512e-06 5.76242899778158e-06 1.25060088767497 0.95 17.3 17 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.37277823629512e-06 5.76242899778158e-06 1.25060088767497 0.95 17.3 17 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 1.37277823629512e-06 5.76242899778158e-06 1.25060088767497 0.95 17.3 17 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 3.02878310303423e-06 1.23141667303363e-05 1.24713661928806 0.947368421052632 17.3 17 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.94753834278352e-10 3.15581295605672e-09 1.23898539955415 0.941176470588235 17.3 17 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 3.19873565339461e-05 0.000111563745950503 1.23414561283715 0.9375 17.3 17 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 3.19873565339461e-05 0.000111563745950503 1.23414561283715 0.9375 17.3 17 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 3.19873565339461e-05 0.000111563745950503 1.23414561283715 0.9375 17.3 17 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 4.09925449205398e-09 2.53619093138818e-08 1.2314915362504 0.935483870967742 17.3 17 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 8.90761689669066e-09 5.37099103558932e-08 1.22866052122454 0.933333333333333 17.3 17 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 8.90761689669066e-09 5.37099103558932e-08 1.22866052122454 0.933333333333333 17.3 17 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 6.97109612962908e-05 0.000225451586192322 1.22866052122454 0.933333333333333 17.3 17 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 6.97109612962908e-05 0.000225451586192322 1.22866052122454 0.933333333333333 17.3 17 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 6.97109612962908e-05 0.000225451586192322 1.22866052122454 0.933333333333333 17.3 17 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.93132578635288e-08 1.09493091393632e-07 1.2256342637831 0.931034482758621 17.3 17 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000151305530252045 0.000457129022396305 1.22239184509584 0.928571428571429 17.3 17 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000151305530252045 0.000457129022396305 1.22239184509584 0.928571428571429 17.3 17 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 9.01335438480766e-08 4.53215663942802e-07 1.21890924724656 0.925925925925926 17.3 17 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.93941203799565e-07 9.16871538228509e-07 1.21515875725504 0.923076923076923 17.3 17 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.93941203799565e-07 9.16871538228509e-07 1.21515875725504 0.923076923076923 17.3 17 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 1.93941203799565e-07 9.16871538228509e-07 1.21515875725504 0.923076923076923 17.3 17 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.000326883889502492 0.000924762971693928 1.21515875725504 0.923076923076923 17.3 17 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.000326883889502492 0.000924762971693928 1.21515875725504 0.923076923076923 17.3 17 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000326883889502492 0.000924762971693928 1.21515875725504 0.923076923076923 17.3 17 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000326883889502492 0.000924762971693928 1.21515875725504 0.923076923076923 17.3 17 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 4.16085205380043e-07 1.87964840398667e-06 1.21110822806419 0.92 17.3 17 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 4.16085205380043e-07 1.87964840398667e-06 1.21110822806419 0.92 17.3 17 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 4.16085205380043e-07 1.87964840398667e-06 1.21110822806419 0.92 17.3 17 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 5.89709171842243e-10 4.48746605097065e-09 1.20968506915929 0.918918918918919 17.3 17 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 5.89709171842243e-10 4.48746605097065e-09 1.20968506915929 0.918918918918919 17.3 17 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.2022249506972e-21 1.19914897495845e-19 1.2080107645653 0.917647058823529 17.3 17 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.2022249506972e-21 1.19914897495845e-19 1.2080107645653 0.917647058823529 17.3 17 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.2022249506972e-21 1.19914897495845e-19 1.2080107645653 0.917647058823529 17.3 17 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 8.89860952409414e-07 3.81641556871809e-06 1.2067201547741 0.916666666666667 17.3 17 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000702450025721113 0.00182406274927216 1.2067201547741 0.916666666666667 17.3 17 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000702450025721113 0.00182406274927216 1.2067201547741 0.916666666666667 17.3 17 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000702450025721113 0.00182406274927216 1.2067201547741 0.916666666666667 17.3 17 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.000702450025721113 0.00182406274927216 1.2067201547741 0.916666666666667 17.3 17 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000702450025721113 0.00182406274927216 1.2067201547741 0.916666666666667 17.3 17 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.97874405441887e-12 4.0441091353129e-11 1.20438607323682 0.914893617021277 17.3 17 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 8.45884744579802e-12 8.13306751038553e-11 1.20195050989357 0.91304347826087 17.3 17 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.89660201770877e-06 7.82279614840457e-06 1.20195050989357 0.91304347826087 17.3 17 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.90061533646284e-16 3.65483192403598e-15 1.19853345087468 0.91044776119403 17.3 17 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 4.0273195381814e-06 1.61433118389637e-05 1.19674726093299 0.909090909090909 17.3 17 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00150018483340762 0.00361824240328652 1.19674726093299 0.909090909090909 17.3 17 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00150018483340762 0.00361824240328652 1.19674726093299 0.909090909090909 17.3 17 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00150018483340762 0.00361824240328652 1.19674726093299 0.909090909090909 17.3 17 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00150018483340762 0.00361824240328652 1.19674726093299 0.909090909090909 17.3 17 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00150018483340762 0.00361824240328652 1.19674726093299 0.909090909090909 17.3 17 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00150018483340762 0.00361824240328652 1.19674726093299 0.909090909090909 17.3 17 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00150018483340762 0.00361824240328652 1.19674726093299 0.909090909090909 17.3 17 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.55274631814179e-08 1.38647252317396e-07 1.19300742574257 0.90625 17.3 17 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 8.51718101643699e-06 3.24931597490344e-05 1.19104846445236 0.904761904761905 17.3 17 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 1.15067214658487e-12 1.51611709684284e-11 1.18984294981222 0.903846153846154 17.3 17 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.30577820272401e-21 5.46506583081255e-20 1.18902631086245 0.903225806451613 17.3 17 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.55964470408475e-10 2.87805364426852e-09 1.18799057365787 0.902439024390244 17.3 17 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.55964470408475e-10 2.87805364426852e-09 1.18799057365787 0.902439024390244 17.3 17 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.55964470408475e-10 2.87805364426852e-09 1.18799057365787 0.902439024390244 17.3 17 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 3.55964470408475e-10 2.87805364426852e-09 1.18799057365787 0.902439024390244 17.3 17 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.41735278949794e-12 2.99121132126571e-11 1.18736100790606 0.901960784313726 17.3 17 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.41735278949794e-12 2.99121132126571e-11 1.18736100790606 0.901960784313726 17.3 17 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 1.79328269036862e-05 6.56000326065436e-05 1.18477978832366 0.9 17.3 17 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 1.79328269036862e-05 6.56000326065436e-05 1.18477978832366 0.9 17.3 17 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00318057319914791 0.00700612331638929 1.18477978832366 0.9 17.3 17 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00318057319914791 0.00700612331638929 1.18477978832366 0.9 17.3 17 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00318057319914791 0.00700612331638929 1.18477978832366 0.9 17.3 17 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00318057319914791 0.00700612331638929 1.18477978832366 0.9 17.3 17 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00318057319914791 0.00700612331638929 1.18477978832366 0.9 17.3 17 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00318057319914791 0.00700612331638929 1.18477978832366 0.9 17.3 17 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00318057319914791 0.00700612331638929 1.18477978832366 0.9 17.3 17 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00318057319914791 0.00700612331638929 1.18477978832366 0.9 17.3 17 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.78654567161613e-22 7.94454528346796e-21 1.18345006914485 0.898989898989899 17.3 17 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.57832648511176e-18 1.0391752221049e-16 1.18311343137806 0.89873417721519 17.3 17 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.57832648511176e-18 1.0391752221049e-16 1.18311343137806 0.89873417721519 17.3 17 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.53886596005603e-24 2.91918750413323e-22 1.1810888855563 0.897196261682243 17.3 17 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.26005539467243e-09 2.03467492395564e-08 1.17785125154984 0.894736842105263 17.3 17 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 3.75736016059811e-05 0.000127912045658639 1.17785125154984 0.894736842105263 17.3 17 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 3.75736016059811e-05 0.000127912045658639 1.17785125154984 0.894736842105263 17.3 17 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 5.02052723780479e-23 2.38140341979874e-21 1.17718504609082 0.894230769230769 17.3 17 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.76326558355048e-17 1.45820104930187e-15 1.17600364174348 0.893333333333333 17.3 17 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.76326558355048e-17 1.45820104930187e-15 1.17600364174348 0.893333333333333 17.3 17 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.76326558355048e-17 1.45820104930187e-15 1.17600364174348 0.893333333333333 17.3 17 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.76326558355048e-17 1.45820104930187e-15 1.17600364174348 0.893333333333333 17.3 17 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.76326558355048e-17 1.45820104930187e-15 1.17600364174348 0.893333333333333 17.3 17 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.37412744286509e-12 1.77762122836093e-11 1.17281231571433 0.890909090909091 17.3 17 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.98444258537789e-10 1.67092414141582e-09 1.1701528773567 0.888888888888889 17.3 17 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.8462077207541e-12 3.13965394312643e-11 1.1701528773567 0.888888888888889 17.3 17 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.40680472441345e-08 8.13773627170869e-08 1.1701528773567 0.888888888888889 17.3 17 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 1.02440248341147e-06 4.35141711610307e-06 1.1701528773567 0.888888888888889 17.3 17 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 7.83025355791714e-05 0.000250392153099238 1.1701528773567 0.888888888888889 17.3 17 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 7.83025355791714e-05 0.000250392153099238 1.1701528773567 0.888888888888889 17.3 17 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.00668469439421146 0.0135696435420298 1.1701528773567 0.888888888888889 17.3 17 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.10161557470145e-10 3.25817340685672e-09 1.16682857940967 0.886363636363636 17.3 17 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 3.78047567006765e-17 8.81904406312501e-16 1.16644986192203 0.886075949367089 17.3 17 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 2.90850259054721e-08 1.53288858753655e-07 1.16597375993757 0.885714285714286 17.3 17 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 5.20264557986533e-22 2.2434438364086e-20 1.16452714236941 0.884615384615385 17.3 17 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 2.11918921749705e-06 8.69050794379916e-06 1.16452714236941 0.884615384615385 17.3 17 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 2.11918921749705e-06 8.69050794379916e-06 1.16452714236941 0.884615384615385 17.3 17 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 8.45423451557812e-10 6.28392020415325e-09 1.16334966295346 0.883720930232558 17.3 17 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 5.99265724290556e-08 3.06746448081101e-07 1.16154881208202 0.882352941176471 17.3 17 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000162206552305532 0.000485936681959521 1.16154881208202 0.882352941176471 17.3 17 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000162206552305532 0.000485936681959521 1.16154881208202 0.882352941176471 17.3 17 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000162206552305532 0.000485936681959521 1.16154881208202 0.882352941176471 17.3 17 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000162206552305532 0.000485936681959521 1.16154881208202 0.882352941176471 17.3 17 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 4.36421643062482e-06 1.72507777243864e-05 1.15845134858313 0.88 17.3 17 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 4.36421643062482e-06 1.72507777243864e-05 1.15845134858313 0.88 17.3 17 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.04566903379657e-17 5.29270370016822e-16 1.15781692834842 0.879518072289157 17.3 17 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.23025433368171e-07 6.06673204121769e-07 1.15685568556856 0.878787878787879 17.3 17 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.04759082688654e-10 9.25889557975981e-10 1.15522745800266 0.877551020408163 17.3 17 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 8.54551627474697e-17 1.76235792158912e-15 1.15390075406008 0.876543209876543 17.3 17 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 8.54551627474697e-17 1.76235792158912e-15 1.15390075406008 0.876543209876543 17.3 17 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.74214955305418e-16 3.39599837533712e-15 1.151869238648 0.875 17.3 17 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 8.94378947480425e-06 3.39386997937239e-05 1.151869238648 0.875 17.3 17 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000333776194632705 0.00093130102933792 1.151869238648 0.875 17.3 17 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000333776194632705 0.00093130102933792 1.151869238648 0.875 17.3 17 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000333776194632705 0.00093130102933792 1.151869238648 0.875 17.3 17 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000333776194632705 0.00093130102933792 1.151869238648 0.875 17.3 17 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000333776194632705 0.00093130102933792 1.151869238648 0.875 17.3 17 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000333776194632705 0.00093130102933792 1.151869238648 0.875 17.3 17 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.000333776194632705 0.00093130102933792 1.151869238648 0.875 17.3 17 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0139013615363881 0.0264460393934229 1.151869238648 0.875 17.3 17 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.17027948515936e-14 1.85034189709086e-13 1.14955159430465 0.873239436619718 17.3 17 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.8799421870106e-13 5.30880551165008e-12 1.14925729026105 0.873015873015873 17.3 17 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.35149367259469e-10 3.42109143431063e-09 1.14836811634208 0.872340425531915 17.3 17 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 4.88419169547772e-24 2.67315568564031e-22 1.14518010253506 0.869918699186992 17.3 17 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 8.83014981154889e-10 6.47696040300725e-09 1.14471477132721 0.869565217391304 17.3 17 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.03499361697985e-25 1.7994982987343e-23 1.14427449641516 0.869230769230769 17.3 17 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 3.00311352045816e-08 1.5769116382332e-07 1.14320856768072 0.868421052631579 17.3 17 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.78632400053046e-09 1.27096952637743e-08 1.14089905542278 0.866666666666667 17.3 17 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 5.97022702034811e-15 9.91392778958954e-14 1.14089905542278 0.866666666666667 17.3 17 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.22487875879305e-12 3.37426652482537e-11 1.14089905542278 0.866666666666667 17.3 17 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.22487875879305e-12 3.37426652482537e-11 1.14089905542278 0.866666666666667 17.3 17 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.22487875879305e-12 3.37426652482537e-11 1.14089905542278 0.866666666666667 17.3 17 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.22487875879305e-12 3.37426652482537e-11 1.14089905542278 0.866666666666667 17.3 17 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.22487875879305e-12 3.37426652482537e-11 1.14089905542278 0.866666666666667 17.3 17 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.22487875879305e-12 3.37426652482537e-11 1.14089905542278 0.866666666666667 17.3 17 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.22487875879305e-12 3.37426652482537e-11 1.14089905542278 0.866666666666667 17.3 17 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.0390938323782e-06 4.40068608176841e-06 1.14089905542278 0.866666666666667 17.3 17 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000681670228464447 0.00178969877325629 1.14089905542278 0.866666666666667 17.3 17 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000681670228464447 0.00178969877325629 1.14089905542278 0.866666666666667 17.3 17 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000681670228464447 0.00178969877325629 1.14089905542278 0.866666666666667 17.3 17 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000681670228464447 0.00178969877325629 1.14089905542278 0.866666666666667 17.3 17 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000681670228464447 0.00178969877325629 1.14089905542278 0.866666666666667 17.3 17 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.96609381953661e-13 2.77005099524811e-12 1.13958918279888 0.865671641791045 17.3 17 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.96609381953661e-13 2.77005099524811e-12 1.13958918279888 0.865671641791045 17.3 17 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.07358943827152e-10 9.25889557975981e-10 1.1392113349266 0.865384615384615 17.3 17 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.07358943827152e-10 9.25889557975981e-10 1.1392113349266 0.865384615384615 17.3 17 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 6.06951278723471e-08 3.09566906675089e-07 1.13852712391463 0.864864864864865 17.3 17 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 6.50101344405762e-12 6.37996009027172e-11 1.13792409048035 0.864406779661017 17.3 17 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 6.50101344405762e-12 6.37996009027172e-11 1.13792409048035 0.864406779661017 17.3 17 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 3.69529703787224e-05 0.000126404030886832 1.13690989788634 0.863636363636364 17.3 17 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 3.69529703787224e-05 0.000126404030886832 1.13690989788634 0.863636363636364 17.3 17 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 3.69529703787224e-05 0.000126404030886832 1.13690989788634 0.863636363636364 17.3 17 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 3.69529703787224e-05 0.000126404030886832 1.13690989788634 0.863636363636364 17.3 17 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.42117559021832e-14 3.66524772859645e-13 1.13609020798159 0.863013698630137 17.3 17 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.22190293605765e-07 6.05842466205587e-07 1.1335855999393 0.861111111111111 17.3 17 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.22190293605765e-07 6.05842466205587e-07 1.1335855999393 0.861111111111111 17.3 17 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.22190293605765e-07 6.05842466205587e-07 1.1335855999393 0.861111111111111 17.3 17 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.66957184586061e-16 6.78155939825928e-15 1.13057417709317 0.858823529411765 17.3 17 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.66957184586061e-16 6.78155939825928e-15 1.13057417709317 0.858823529411765 17.3 17 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.39555024334051e-18 4.51333635516715e-17 1.13026130199227 0.858585858585859 17.3 17 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.24290788706683e-11 4.78247302775391e-10 1.12836170316539 0.857142857142857 17.3 17 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 4.21211256023668e-06 1.67425591430637e-05 1.12836170316539 0.857142857142857 17.3 17 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 4.21211256023668e-06 1.67425591430637e-05 1.12836170316539 0.857142857142857 17.3 17 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 4.21211256023668e-06 1.67425591430637e-05 1.12836170316539 0.857142857142857 17.3 17 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00138035404500517 0.0033749893574611 1.12836170316539 0.857142857142857 17.3 17 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00138035404500517 0.0033749893574611 1.12836170316539 0.857142857142857 17.3 17 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00138035404500517 0.0033749893574611 1.12836170316539 0.857142857142857 17.3 17 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00138035404500517 0.0033749893574611 1.12836170316539 0.857142857142857 17.3 17 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00138035404500517 0.0033749893574611 1.12836170316539 0.857142857142857 17.3 17 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00138035404500517 0.0033749893574611 1.12836170316539 0.857142857142857 17.3 17 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00138035404500517 0.0033749893574611 1.12836170316539 0.857142857142857 17.3 17 3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.028531146524762 0.0501851934545567 1.12836170316539 0.857142857142857 17.3 17 3 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.028531146524762 0.0501851934545567 1.12836170316539 0.857142857142857 17.3 17 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.028531146524762 0.0501851934545567 1.12836170316539 0.857142857142857 17.3 17 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.028531146524762 0.0501851934545567 1.12836170316539 0.857142857142857 17.3 17 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.028531146524762 0.0501851934545567 1.12836170316539 0.857142857142857 17.3 17 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.028531146524762 0.0501851934545567 1.12836170316539 0.857142857142857 17.3 17 3 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.028531146524762 0.0501851934545567 1.12836170316539 0.857142857142857 17.3 17 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.028531146524762 0.0501851934545567 1.12836170316539 0.857142857142857 17.3 17 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.31079913585352e-37 1.69569742756323e-35 1.12836170316539 0.857142857142857 17.3 17 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.44969603792808e-08 8.31821557246636e-08 1.12836170316539 0.857142857142857 17.3 17 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.44969603792808e-08 8.31821557246636e-08 1.12836170316539 0.857142857142857 17.3 17 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.44975851570557e-07 1.13921776727092e-06 1.12836170316539 0.857142857142857 17.3 17 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.44975851570557e-07 1.13921776727092e-06 1.12836170316539 0.857142857142857 17.3 17 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 2.44975851570557e-07 1.13921776727092e-06 1.12836170316539 0.857142857142857 17.3 17 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 7.44267022271814e-05 0.000239072680066093 1.12836170316539 0.857142857142857 17.3 17 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 7.44267022271814e-05 0.000239072680066093 1.12836170316539 0.857142857142857 17.3 17 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 7.44267022271814e-05 0.000239072680066093 1.12836170316539 0.857142857142857 17.3 17 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.89241781439802e-08 1.53007827133397e-07 1.12377486697366 0.853658536585366 17.3 17 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.89241781439802e-08 1.53007827133397e-07 1.12377486697366 0.853658536585366 17.3 17 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.89241781439802e-08 1.53007827133397e-07 1.12377486697366 0.853658536585366 17.3 17 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.89241781439802e-08 1.53007827133397e-07 1.12377486697366 0.853658536585366 17.3 17 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.89241781439802e-08 1.53007827133397e-07 1.12377486697366 0.853658536585366 17.3 17 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.89241781439802e-08 1.53007827133397e-07 1.12377486697366 0.853658536585366 17.3 17 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.53598753498139e-30 4.03419391392408e-28 1.12283051834595 0.852941176470588 17.3 17 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 4.88998826815036e-07 2.20204218530948e-06 1.12283051834595 0.852941176470588 17.3 17 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 9.01512649191991e-30 7.12695833222335e-28 1.12168500669696 0.85207100591716 17.3 17 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 8.41421293848905e-06 3.21866263749191e-05 1.12139650746684 0.851851851851852 17.3 17 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 8.41421293848905e-06 3.21866263749191e-05 1.12139650746684 0.851851851851852 17.3 17 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 8.41421293848905e-06 3.21866263749191e-05 1.12139650746684 0.851851851851852 17.3 17 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 8.41421293848905e-06 3.21866263749191e-05 1.12139650746684 0.851851851851852 17.3 17 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 8.41421293848905e-06 3.21866263749191e-05 1.12139650746684 0.851851851851852 17.3 17 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 6.73314462194819e-45 9.58126479703228e-43 1.11971525333271 0.850574712643678 17.3 17 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 5.35170488464569e-18 1.49323059820604e-16 1.11895868897235 0.85 17.3 17 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000148871324918985 0.000451692740639051 1.11895868897235 0.85 17.3 17 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000148871324918985 0.000451692740639051 1.11895868897235 0.85 17.3 17 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000148871324918985 0.000451692740639051 1.11895868897235 0.85 17.3 17 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000148871324918985 0.000451692740639051 1.11895868897235 0.85 17.3 17 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000148871324918985 0.000451692740639051 1.11895868897235 0.85 17.3 17 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 4.12137184282649e-10 3.25817340685672e-09 1.11771678143742 0.849056603773585 17.3 17 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 6.81904567990864e-09 4.16459313412446e-08 1.11609690204403 0.847826086956522 17.3 17 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.09011212676715e-17 5.31112420783867e-16 1.11492882574675 0.846938775510204 17.3 17 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 5.43301575861985e-28 3.86559071225802e-26 1.1145167742922 0.846625766871166 17.3 17 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 3.47407375669098e-49 7.06229565110181e-47 1.11424113577652 0.84641638225256 17.3 17 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 1.67118661028275e-05 6.1929649646676e-05 1.11389552748378 0.846153846153846 17.3 17 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.67118661028275e-05 6.1929649646676e-05 1.11389552748378 0.846153846153846 17.3 17 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 1.67118661028275e-05 6.1929649646676e-05 1.11389552748378 0.846153846153846 17.3 17 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.67118661028275e-05 6.1929649646676e-05 1.11389552748378 0.846153846153846 17.3 17 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00276806377492353 0.00627658560413166 1.11389552748378 0.846153846153846 17.3 17 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00276806377492353 0.00627658560413166 1.11389552748378 0.846153846153846 17.3 17 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00276806377492353 0.00627658560413166 1.11389552748378 0.846153846153846 17.3 17 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00276806377492353 0.00627658560413166 1.11389552748378 0.846153846153846 17.3 17 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.00276806377492353 0.00627658560413166 1.11389552748378 0.846153846153846 17.3 17 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.13386079546922e-19 1.08767900291529e-17 1.11297495266768 0.845454545454545 17.3 17 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.42549972058473e-12 1.82746495710997e-11 1.1095556747793 0.842857142857143 17.3 17 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000295523516769519 0.000847842670086744 1.10856588381161 0.842105263157895 17.3 17 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.79591099515175e-12 3.10826667664136e-11 1.10655761228297 0.840579710144927 17.3 17 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 8.38798462772673e-69 2.38722042505103e-66 1.10628889989533 0.84037558685446 17.3 17 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 3.29865479567461e-05 0.000113931693549635 1.10579446910208 0.84 17.3 17 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 3.29865479567461e-05 0.000113931693549635 1.10579446910208 0.84 17.3 17 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 3.29865479567461e-05 0.000113931693549635 1.10579446910208 0.84 17.3 17 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.88435865990709e-26 1.86565562411263e-24 1.10250341413452 0.8375 17.3 17 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.29110055936265e-12 1.68553770272758e-11 1.10002385217265 0.835616438356164 17.3 17 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 8.58903641394523e-07 3.74914074142456e-06 1.09701832252191 0.833333333333333 17.3 17 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 6.46736706739721e-05 0.000211079434332712 1.09701832252191 0.833333333333333 17.3 17 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 6.46736706739721e-05 0.000211079434332712 1.09701832252191 0.833333333333333 17.3 17 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 6.46736706739721e-05 0.000211079434332712 1.09701832252191 0.833333333333333 17.3 17 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 6.46736706739721e-05 0.000211079434332712 1.09701832252191 0.833333333333333 17.3 17 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000581726635937335 0.00155961481284477 1.09701832252191 0.833333333333333 17.3 17 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.000581726635937335 0.00155961481284477 1.09701832252191 0.833333333333333 17.3 17 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000581726635937335 0.00155961481284477 1.09701832252191 0.833333333333333 17.3 17 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000581726635937335 0.00155961481284477 1.09701832252191 0.833333333333333 17.3 17 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00548885887184015 0.0116057149697304 1.09701832252191 0.833333333333333 17.3 17 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_196559.2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 VITAMINS%REACTOME%REACT_213027.1 VITAMINS 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.057582576117893 0.0933257469427811 1.09701832252191 0.833333333333333 17.3 17 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 9.41521495429519e-80 4.46595029332069e-77 1.09117868126133 0.828897338403042 17.3 17 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 1.66844320716336e-06 6.92185039006838e-06 1.09074964639321 0.828571428571429 17.3 17 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 7.78593820817689e-11 7.05693635046861e-10 1.09016195800615 0.828125 17.3 17 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 6.45668767589551e-10 4.86130505968217e-09 1.08945267891831 0.827586206896552 17.3 17 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 6.45668767589551e-10 4.86130505968217e-09 1.08945267891831 0.827586206896552 17.3 17 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.43632048924444e-05 5.40710067776413e-05 1.08945267891831 0.827586206896552 17.3 17 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.50105137013964e-10 1.28674463837874e-09 1.08657052897408 0.825396825396825 17.3 17 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 8.24460000079221e-34 9.02466600086716e-32 1.08619572023694 0.825112107623318 17.3 17 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 3.79172657181518e-07 1.7349282674254e-06 1.08604813929669 0.825 17.3 17 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.79172657181518e-07 1.7349282674254e-06 1.08604813929669 0.825 17.3 17 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.50121665770492e-18 4.74718067536466e-17 1.08411222460989 0.823529411764706 17.3 17 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.03542129983282e-08 6.11371165834899e-08 1.08411222460988 0.823529411764706 17.3 17 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00113443452549284 0.00286731852535758 1.08411222460988 0.823529411764706 17.3 17 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00113443452549284 0.00286731852535758 1.08411222460988 0.823529411764706 17.3 17 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00113443452549284 0.00286731852535758 1.08411222460988 0.823529411764706 17.3 17 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00113443452549284 0.00286731852535758 1.08411222460988 0.823529411764706 17.3 17 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.83233142156259e-14 4.24253432935112e-13 1.08239141155495 0.822222222222222 17.3 17 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 2.774387467845e-05 9.77216179886989e-05 1.08134663220017 0.821428571428571 17.3 17 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.98626682080677e-08 1.11717695099132e-07 1.07946602936156 0.82 17.3 17 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.98626682080677e-08 1.11717695099132e-07 1.07946602936156 0.82 17.3 17 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 5.52512798064673e-10 4.27389512199767e-09 1.07903441559532 0.819672131147541 17.3 17 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.52512798064673e-10 4.27389512199767e-09 1.07903441559532 0.819672131147541 17.3 17 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.65943867825642e-07 7.92409811798282e-07 1.07707253483969 0.818181818181818 17.3 17 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.65943867825642e-07 7.92409811798282e-07 1.07707253483969 0.818181818181818 17.3 17 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000243058495545248 0.000704424112343967 1.07707253483969 0.818181818181818 17.3 17 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000243058495545248 0.000704424112343967 1.07707253483969 0.818181818181818 17.3 17 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0107423208449793 0.0209641237056207 1.07707253483969 0.818181818181818 17.3 17 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.0546464218692e-09 7.65694825673405e-09 1.07507795607147 0.816666666666667 17.3 17 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.62961199449068e-16 3.22074703911145e-15 1.07487666830587 0.81651376146789 17.3 17 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.43920780266533e-10 2.02982029426477e-09 1.07339023557528 0.815384615384615 17.3 17 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 5.32215400259166e-05 0.000176536716682702 1.07264013757698 0.814814814814815 17.3 17 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.7456585490493e-13 5.174827296405e-12 1.07150626850977 0.813953488372093 17.3 17 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.91906929664692e-19 1.66662752598299e-17 1.07150626850977 0.813953488372093 17.3 17 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 1.18245313980759e-05 4.4632117186902e-05 1.06959286445886 0.8125 17.3 17 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00218921104173533 0.00511534862461309 1.06959286445886 0.8125 17.3 17 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00218921104173533 0.00511534862461309 1.06959286445886 0.8125 17.3 17 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00218921104173533 0.00511534862461309 1.06959286445886 0.8125 17.3 17 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00218921104173533 0.00511534862461309 1.06959286445886 0.8125 17.3 17 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00218921104173533 0.00511534862461309 1.06959286445886 0.8125 17.3 17 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.00218921104173533 0.00511534862461309 1.06959286445886 0.8125 17.3 17 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00218921104173533 0.00511534862461309 1.06959286445886 0.8125 17.3 17 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.18495166237641e-19 7.77296553890407e-18 1.06897424510405 0.81203007518797 17.3 17 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.07178942957074e-10 9.25889557975981e-10 1.06840045323873 0.811594202898551 17.3 17 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.07178942957074e-10 9.25889557975981e-10 1.06840045323873 0.811594202898551 17.3 17 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 3.80149435687889e-09 2.36223863311732e-08 1.06675574810751 0.810344827586207 17.3 17 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 8.76478431995182e-10 6.46232543382976e-09 1.06567494187842 0.80952380952381 17.3 17 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000465260971359149 0.00128307434543424 1.06567494187842 0.80952380952381 17.3 17 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000465260971359149 0.00128307434543424 1.06567494187842 0.80952380952381 17.3 17 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.36697990317996e-07 6.6163687150513e-07 1.06434118099998 0.808510638297872 17.3 17 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.65272464372737e-09 1.18182269749952e-08 1.06163063469862 0.806451612903226 17.3 17 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 6.58585663577829e-30 5.51274940747794e-28 1.0591213259257 0.804545454545455 17.3 17 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.57661685575739e-07 1.19430807353184e-06 1.05886116347767 0.804347826086957 17.3 17 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 5.88473345679991e-08 3.0230959238362e-07 1.05830002878584 0.803921568627451 17.3 17 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.34950135943125e-08 7.83812422232925e-08 1.05783909671755 0.803571428571429 17.3 17 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.10502538573769e-09 1.94645423960561e-08 1.05745372728341 0.80327868852459 17.3 17 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 9.72755842224822e-18 2.61175766695457e-16 1.05728380060379 0.803149606299213 17.3 17 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.27547669434974e-18 6.88936880012698e-17 1.05712674715747 0.803030303030303 17.3 17 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.6611102807081e-15 4.56236136078028e-14 1.05313758962103 0.8 17.3 17 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 5.81137953363485e-09 3.56447977429414e-08 1.05313758962103 0.8 17.3 17 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 2.52720135033723e-08 1.38315673904995e-07 1.05313758962103 0.8 17.3 17 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.52720135033723e-08 1.38315673904995e-07 1.05313758962103 0.8 17.3 17 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.52720135033723e-08 1.38315673904995e-07 1.05313758962103 0.8 17.3 17 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 2.52720135033723e-08 1.38315673904995e-07 1.05313758962103 0.8 17.3 17 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.52720135033723e-08 1.38315673904995e-07 1.05313758962103 0.8 17.3 17 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 2.52720135033723e-08 1.38315673904995e-07 1.05313758962103 0.8 17.3 17 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 2.12920442304549e-06 8.70648820113142e-06 1.05313758962103 0.8 17.3 17 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000882132284171654 0.00226175538806534 1.05313758962103 0.8 17.3 17 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.000882132284171654 0.00226175538806534 1.05313758962103 0.8 17.3 17 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000882132284171654 0.00226175538806534 1.05313758962103 0.8 17.3 17 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00417508931116809 0.00897454998458035 1.05313758962103 0.8 17.3 17 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00417508931116809 0.00897454998458035 1.05313758962103 0.8 17.3 17 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00417508931116809 0.00897454998458035 1.05313758962103 0.8 17.3 17 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00417508931116809 0.00897454998458035 1.05313758962103 0.8 17.3 17 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00417508931116809 0.00897454998458035 1.05313758962103 0.8 17.3 17 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0207011791744655 0.0372883265383095 1.05313758962103 0.8 17.3 17 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0207011791744655 0.0372883265383095 1.05313758962103 0.8 17.3 17 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0207011791744655 0.0372883265383095 1.05313758962103 0.8 17.3 17 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0207011791744655 0.0372883265383095 1.05313758962103 0.8 17.3 17 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0207011791744655 0.0372883265383095 1.05313758962103 0.8 17.3 17 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0207011791744655 0.0372883265383095 1.05313758962103 0.8 17.3 17 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0207011791744655 0.0372883265383095 1.05313758962103 0.8 17.3 17 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0207011791744655 0.0372883265383095 1.05313758962103 0.8 17.3 17 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 9.44412615936054e-06 3.57419987360906e-05 1.05313758962103 0.8 17.3 17 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.19556511035392e-24 1.81891566081345e-22 1.05026016451278 0.797814207650273 17.3 17 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 7.20741922536515e-12 6.9769779304045e-11 1.05000325155668 0.797619047619048 17.3 17 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 7.20741922536515e-12 6.9769779304045e-11 1.05000325155668 0.797619047619048 17.3 17 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 5.77333950237242e-10 4.44079033074376e-09 1.04932187371661 0.797101449275362 17.3 17 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.0833874498117e-08 6.37049727719856e-08 1.04867514220738 0.796610169491525 17.3 17 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 9.21472713545262e-15 1.47332097907293e-13 1.04826195263204 0.796296296296296 17.3 17 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 4.71251958027803e-08 2.45637925374932e-07 1.04826195263204 0.796296296296296 17.3 17 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.93544357207978e-67 4.59022700511588e-65 1.04771412825126 0.795880149812734 17.3 17 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.3389026706965e-11 1.27869698013498e-10 1.04679338727392 0.795180722891566 17.3 17 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 1.76451365221868e-05 6.48812125867488e-05 1.04539393087382 0.794117647058823 17.3 17 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 1.76451365221868e-05 6.48812125867488e-05 1.04539393087382 0.794117647058823 17.3 17 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.04308526613708e-16 7.28267130849754e-15 1.04443397317788 0.793388429752066 17.3 17 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.04308526613708e-16 7.28267130849754e-15 1.04443397317788 0.793388429752066 17.3 17 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.01148436180044e-08 1.1269063963945e-07 1.04405881729671 0.793103448275862 17.3 17 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 7.90364421914712e-05 0.000251608181741529 1.04405881729671 0.793103448275862 17.3 17 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 7.90364421914712e-05 0.000251608181741529 1.04405881729671 0.793103448275862 17.3 17 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.47981673021009e-11 2.33693987224434e-10 1.0435052336184 0.792682926829268 17.3 17 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 8.74862495089963e-08 4.41464301600361e-07 1.04320232934159 0.792452830188679 17.3 17 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000358450085309269 0.000998188789422876 1.04216740639581 0.791666666666667 17.3 17 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 8.57908202869981e-09 5.21710843027343e-08 1.04039802200465 0.790322580645161 17.3 17 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.96896351362442e-10 1.66775897612355e-09 1.03928051607339 0.789473684210526 17.3 17 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00165498833281665 0.00397812229324002 1.03928051607339 0.789473684210526 17.3 17 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00165498833281665 0.00397812229324002 1.03928051607339 0.789473684210526 17.3 17 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 8.47865551087438e-10 6.28392020415325e-09 1.03830466582355 0.788732394366197 17.3 17 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.61667151747587e-07 7.77203908570324e-07 1.03794810515534 0.788461538461538 17.3 17 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.61667151747587e-07 7.77203908570324e-07 1.03794810515534 0.788461538461538 17.3 17 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 3.27426737970003e-05 0.000113918887073671 1.03718095947526 0.787878787878788 17.3 17 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.42628594308173e-33 3.48257492643236e-31 1.0357143574398 0.786764705882353 17.3 17 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000146639646299961 0.00044971598423458 1.03433156123494 0.785714285714286 17.3 17 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000146639646299961 0.00044971598423458 1.03433156123494 0.785714285714286 17.3 17 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00785633278462416 0.015790341175876 1.03433156123494 0.785714285714286 17.3 17 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00785633278462416 0.015790341175876 1.03433156123494 0.785714285714286 17.3 17 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00785633278462416 0.015790341175876 1.03433156123494 0.785714285714286 17.3 17 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 8.46642377424305e-14 1.22935928885182e-12 1.03345277486176 0.785046728971963 17.3 17 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.54628596331623e-10 1.31758378790359e-09 1.0331413062738 0.784810126582278 17.3 17 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.85346074912641e-09 1.82084064843358e-08 1.03024329419449 0.782608695652174 17.3 17 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00066491155410537 0.0017619537085511 1.03024329419449 0.782608695652174 17.3 17 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00066491155410537 0.0017619537085511 1.03024329419449 0.782608695652174 17.3 17 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.56853125508554e-15 2.72197558047161e-14 1.02978171565766 0.782258064516129 17.3 17 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.56853125508554e-15 2.72197558047161e-14 1.02978171565766 0.782258064516129 17.3 17 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.56853125508554e-15 2.72197558047161e-14 1.02978171565766 0.782258064516129 17.3 17 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 1.2543243237566e-07 6.14632439833039e-07 1.02920264440237 0.781818181818182 17.3 17 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.81614743953032e-11 2.61920118068735e-10 1.02892753008951 0.781609195402299 17.3 17 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.81614743953032e-11 2.61920118068735e-10 1.02892753008951 0.781609195402299 17.3 17 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.22824587369555e-08 7.16308966503591e-08 1.02845467736429 0.78125 17.3 17 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.22824587369555e-08 7.16308966503591e-08 1.02845467736429 0.78125 17.3 17 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.21251979791483e-09 8.7584551900142e-09 1.02789114055477 0.780821917808219 17.3 17 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.68855316188442e-22 7.75100370761786e-21 1.02779470644833 0.780748663101604 17.3 17 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 5.44045893777045e-07 2.44219970613481e-06 1.02680914988051 0.78 17.3 17 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.2065763227466e-09 1.4143955438146e-08 1.02388376768711 0.777777777777778 17.3 17 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.28749937480751e-07 1.07429426084194e-06 1.02388376768711 0.777777777777778 17.3 17 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.36684971424477e-06 9.65050757412695e-06 1.02388376768711 0.777777777777778 17.3 17 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000269755562753713 0.000775479122825319 1.02388376768711 0.777777777777778 17.3 17 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00306891213893713 0.00685567028839487 1.02388376768711 0.777777777777778 17.3 17 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00306891213893713 0.00685567028839487 1.02388376768711 0.777777777777778 17.3 17 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00306891213893713 0.00685567028839487 1.02388376768711 0.777777777777778 17.3 17 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00306891213893713 0.00685567028839487 1.02388376768711 0.777777777777778 17.3 17 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0391596965340065 0.0660239907202502 1.02388376768711 0.777777777777778 17.3 17 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 9.35732229479428e-10 6.8284459617909e-09 1.02195917413883 0.776315789473684 17.3 17 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 9.45747870621618e-09 5.65461857098556e-08 1.02170064664727 0.776119402985075 17.3 17 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 9.45747870621618e-09 5.65461857098556e-08 1.02170064664727 0.776119402985075 17.3 17 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.77315243383243e-18 5.48520850726859e-17 1.02107090019347 0.775641025641026 17.3 17 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.69450543574122e-13 2.43563761117147e-12 1.01993054850685 0.774774774774775 17.3 17 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000110252725790084 0.000343303345293852 1.01916540931068 0.774193548387097 17.3 17 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00122074938912641 0.00302108935778587 1.01723517179304 0.772727272727273 17.3 17 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00122074938912641 0.00302108935778587 1.01723517179304 0.772727272727273 17.3 17 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00122074938912641 0.00302108935778587 1.01723517179304 0.772727272727273 17.3 17 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 8.63021456642652e-24 4.38599833143748e-22 1.01552553284885 0.771428571428571 17.3 17 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 4.53235464967257e-05 0.000151043106943421 1.01552553284885 0.771428571428571 17.3 17 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.79294500582459e-06 7.41674634676858e-06 1.01474194833276 0.770833333333333 17.3 17 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 3.0521860459816e-09 1.93033810819192e-08 1.01400071973647 0.77027027027027 17.3 17 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 3.0521860459816e-09 1.93033810819192e-08 1.01400071973647 0.77027027027027 17.3 17 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.47569823027094e-12 5.48726660681377e-11 1.01364493001024 0.77 17.3 17 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0145581758615623 0.0274024923955068 1.01263229771253 0.769230769230769 17.3 17 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0145581758615623 0.0274024923955068 1.01263229771253 0.769230769230769 17.3 17 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0145581758615623 0.0274024923955068 1.01263229771253 0.769230769230769 17.3 17 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0145581758615623 0.0274024923955068 1.01263229771253 0.769230769230769 17.3 17 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0145581758615623 0.0274024923955068 1.01263229771253 0.769230769230769 17.3 17 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0145581758615623 0.0274024923955068 1.01263229771253 0.769230769230769 17.3 17 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.31536586663211e-11 2.19651041881166e-10 1.0115663689781 0.768421052631579 17.3 17 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 4.20207043721947e-13 5.69480593539363e-12 1.01082402575233 0.767857142857143 17.3 17 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.31057490079195e-10 1.9340871081335e-09 1.01027733888064 0.767441860465116 17.3 17 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.08936261924093e-17 2.87067223551823e-16 1.00814595208975 0.765822784810127 17.3 17 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.64223704769944e-20 1.32894956894264e-18 1.00709878788896 0.765027322404372 17.3 17 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 8.1809669940144e-05 0.000259855268582199 1.00667563713775 0.764705882352941 17.3 17 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0056172347195234 0.0118069793292198 1.00667563713775 0.764705882352941 17.3 17 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0056172347195234 0.0118069793292198 1.00667563713775 0.764705882352941 17.3 17 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0056172347195234 0.0118069793292198 1.00667563713775 0.764705882352941 17.3 17 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0056172347195234 0.0118069793292198 1.00667563713775 0.764705882352941 17.3 17 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 9.80422532811634e-09 5.81308860079564e-08 1.00560012897842 0.763888888888889 17.3 17 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 9.80422532811634e-09 5.81308860079564e-08 1.00560012897842 0.763888888888889 17.3 17 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 8.13869086095434e-17 1.72856076046836e-15 1.00463783220427 0.763157894736842 17.3 17 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 5.6936581044478e-13 7.64346743644267e-12 1.00463783220427 0.763157894736842 17.3 17 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 6.26915109407454e-18 1.71557730901309e-16 1.00337041694077 0.76219512195122 17.3 17 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00221612048517168 0.00516973680393328 1.00298818059146 0.761904761904762 17.3 17 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.8272441997011e-27 1.23817547436889e-25 1.0025059747354 0.761538461538461 17.3 17 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.11377272245225e-10 2.57610382793579e-09 1.00227583103138 0.761363636363636 17.3 17 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 5.77550460369921e-06 2.25784149754505e-05 1.00162542491131 0.760869565217391 17.3 17 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 5.77550460369921e-06 2.25784149754505e-05 1.00162542491131 0.760869565217391 17.3 17 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000887371843902847 0.00227109736308229 1.00048071013998 0.76 17.3 17 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.10113664835234e-09 1.94645423960561e-08 0.999814167361738 0.759493670886076 17.3 17 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.52632960258308e-10 4.27389512199767e-09 0.998664955675116 0.758620689655172 17.3 17 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 9.87687997740649e-11 8.7842501299059e-10 0.997709295430451 0.757894736842105 17.3 17 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 9.87687997740649e-11 8.7842501299059e-10 0.997709295430451 0.757894736842105 17.3 17 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000146486146183272 0.00044971598423458 0.997289384110825 0.757575757575758 17.3 17 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000146486146183272 0.00044971598423458 0.997289384110825 0.757575757575758 17.3 17 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 3.09849023647382e-08 1.62101162003759e-07 0.996719504462761 0.757142857142857 17.3 17 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 7.86105091373865e-15 1.27116766480115e-13 0.994419486602592 0.755395683453237 17.3 17 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.85396308447212e-98 2.63818946920382e-95 0.993575753971794 0.754754754754755 17.3 17 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.08746709738922e-16 2.17952912617586e-15 0.993526027944369 0.754716981132076 17.3 17 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.30335540007932e-07 6.32994789867873e-07 0.992379651758279 0.753846153846154 17.3 17 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.82506169950698e-21 1.14858937097098e-19 0.990450828334065 0.752380952380952 17.3 17 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.10369495992952e-85 7.85278963989855e-83 0.990294820557106 0.752262443438914 17.3 17 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.89663067774787e-48 1.2267381818044e-45 0.989992144714892 0.752032520325203 17.3 17 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.35770286381183e-16 6.37068156693899e-15 0.989412703624854 0.751592356687898 17.3 17 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.65228214202438e-18 1.32403949762014e-16 0.989175843358737 0.751412429378531 17.3 17 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000260060356397505 0.000752166437304165 0.987316490269717 0.75 17.3 17 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.000639103312114967 0.0016998953516628 0.987316490269717 0.75 17.3 17 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000639103312114967 0.0016998953516628 0.987316490269717 0.75 17.3 17 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.000639103312114967 0.0016998953516628 0.987316490269717 0.75 17.3 17 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0101327241194664 0.0201944907871158 0.987316490269717 0.75 17.3 17 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0101327241194664 0.0201944907871158 0.987316490269717 0.75 17.3 17 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0724205014898839 0.115531808991149 0.987316490269717 0.75 17.3 17 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0724205014898839 0.115531808991149 0.987316490269717 0.75 17.3 17 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0724205014898839 0.115531808991149 0.987316490269717 0.75 17.3 17 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0724205014898839 0.115531808991149 0.987316490269717 0.75 17.3 17 3 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 48%5605104 DISSOLUTION OF FIBRIN CLOT 0.0724205014898839 0.115531808991149 0.987316490269717 0.75 17.3 17 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0724205014898839 0.115531808991149 0.987316490269717 0.75 17.3 17 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.80781887972575e-14 2.76615727510724e-13 0.987316490269717 0.75 17.3 17 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.7022650871485e-08 9.68929287604926e-08 0.987316490269717 0.75 17.3 17 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 4.38720820416701e-05 0.000146894053518345 0.987316490269717 0.75 17.3 17 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000106532107621695 0.000332445590231736 0.987316490269717 0.75 17.3 17 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00397355647875162 0.0086326272813184 0.987316490269717 0.75 17.3 17 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.15998586569942e-14 4.68402071551071e-13 0.984948824825425 0.748201438848921 17.3 17 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 3.18379843307633e-05 0.000111563745950503 0.979662874066075 0.744186046511628 17.3 17 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.06624604740127e-14 1.03662557994351e-12 0.977913476076672 0.742857142857143 17.3 17 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.93491955340814e-07 1.35158269401287e-06 0.977343596428608 0.742424242424242 17.3 17 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 3.99355761562376e-15 6.76527677027691e-14 0.97670018392273 0.741935483870968 17.3 17 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000457498658232793 0.00126657702464059 0.97670018392273 0.741935483870968 17.3 17 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00112580894122198 0.00286587857488172 0.975127397797251 0.740740740740741 17.3 17 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.7385826359947e-10 3.00565146385337e-09 0.974152270399454 0.74 17.3 17 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.7583517335134e-12 3.84757878905724e-11 0.97393821804384 0.739837398373984 17.3 17 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.21022448242882e-17 5.51780603244948e-16 0.973007555628126 0.739130434782609 17.3 17 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 5.54623944405202e-05 0.000183115979788539 0.971644799947975 0.738095238095238 17.3 17 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000134194919924722 0.000415129067506258 0.96999514833516 0.736842105263158 17.3 17 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.50060164199041e-14 2.32103927886126e-13 0.968207138845141 0.735483870967742 17.3 17 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000326143024636404 0.000924762971693928 0.967957343401683 0.735294117647059 17.3 17 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000326143024636404 0.000924762971693928 0.967957343401683 0.735294117647059 17.3 17 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000326143024636404 0.000924762971693928 0.967957343401683 0.735294117647059 17.3 17 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.65693876639901e-05 6.1929649646676e-05 0.967167174141763 0.73469387755102 17.3 17 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000797023128906209 0.00205464476890133 0.965376123819278 0.733333333333333 17.3 17 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000797023128906209 0.00205464476890133 0.965376123819278 0.733333333333333 17.3 17 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0179797523366284 0.0328015225320797 0.965376123819278 0.733333333333333 17.3 17 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0179797523366284 0.0328015225320797 0.965376123819278 0.733333333333333 17.3 17 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0179797523366284 0.0328015225320797 0.965376123819278 0.733333333333333 17.3 17 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 5.92014411569904e-12 5.89116438925856e-11 0.963994053491692 0.732283464566929 17.3 17 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00196135095974003 0.00464393080816982 0.962000682826903 0.730769230769231 17.3 17 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00196135095974003 0.00464393080816982 0.962000682826903 0.730769230769231 17.3 17 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00196135095974003 0.00464393080816982 0.962000682826903 0.730769230769231 17.3 17 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00196135095974003 0.00464393080816982 0.962000682826903 0.730769230769231 17.3 17 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 8.15334136181205e-08 4.12889849034112e-07 0.962000682826903 0.730769230769231 17.3 17 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.58116236187971e-06 1.44362437420817e-05 0.959426193934414 0.728813559322034 17.3 17 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 7.01755066248142e-13 9.33268653524398e-12 0.957397808746392 0.727272727272727 17.3 17 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0472581347197623 0.0791156773014374 0.957397808746392 0.727272727272727 17.3 17 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0472581347197623 0.0791156773014374 0.957397808746392 0.727272727272727 17.3 17 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0472581347197623 0.0791156773014374 0.957397808746392 0.727272727272727 17.3 17 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0472581347197623 0.0791156773014374 0.957397808746392 0.727272727272727 17.3 17 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.000562924916968792 0.00152289383430911 0.957397808746392 0.727272727272727 17.3 17 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.22304077597928e-09 8.78983345564909e-09 0.952838771561885 0.723809523809524 17.3 17 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0122428734290477 0.0237675428233764 0.95074921285232 0.722222222222222 17.3 17 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 8.34302304325378e-11 7.51400113325958e-10 0.94955028572388 0.721311475409836 17.3 17 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 4.83923910665902e-09 2.98105508605012e-08 0.947823830658928 0.72 17.3 17 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00337638654601295 0.00740307866714395 0.947823830658928 0.72 17.3 17 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00337638654601295 0.00740307866714395 0.947823830658928 0.72 17.3 17 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00337638654601295 0.00740307866714395 0.947823830658928 0.72 17.3 17 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 8.15783517435747e-26 5.04721715352638e-24 0.944916395595557 0.717791411042945 17.3 17 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.1075980304837e-11 2.85297548217955e-10 0.944608143362375 0.717557251908397 17.3 17 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.1075980304837e-11 2.85297548217955e-10 0.944608143362375 0.717557251908397 17.3 17 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.04141769285572e-07 9.6189979368665e-07 0.942623151204009 0.716049382716049 17.3 17 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 5.82834821723744e-05 0.000191984710952057 0.940301419304492 0.714285714285714 17.3 17 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0313127835539076 0.0547396695297426 0.940301419304492 0.714285714285714 17.3 17 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0313127835539076 0.0547396695297426 0.940301419304492 0.714285714285714 17.3 17 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0313127835539076 0.0547396695297426 0.940301419304492 0.714285714285714 17.3 17 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0313127835539076 0.0547396695297426 0.940301419304492 0.714285714285714 17.3 17 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.130211150100721 0.188879170839272 0.940301419304492 0.714285714285714 17.3 17 3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.130211150100721 0.188879170839272 0.940301419304492 0.714285714285714 17.3 17 3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.130211150100721 0.188879170839272 0.940301419304492 0.714285714285714 17.3 17 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.130211150100721 0.188879170839272 0.940301419304492 0.714285714285714 17.3 17 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.130211150100721 0.188879170839272 0.940301419304492 0.714285714285714 17.3 17 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 1.57931287658576e-06 6.57123457129106e-06 0.940301419304492 0.714285714285714 17.3 17 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000196947798497436 0.000582654297841687 0.940301419304492 0.714285714285714 17.3 17 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00836714646270145 0.0167696470653861 0.940301419304492 0.714285714285714 17.3 17 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 7.41962022267383e-08 3.77075699173745e-07 0.936122301885361 0.711111111111111 17.3 17 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 7.27154814976137e-15 1.18935781805867e-13 0.932465574143621 0.708333333333333 17.3 17 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 9.75700290355022e-05 0.00030514758531323 0.932465574143621 0.708333333333333 17.3 17 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 9.75700290355022e-05 0.00030514758531323 0.932465574143621 0.708333333333333 17.3 17 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00573741811315318 0.0120418082227389 0.932465574143621 0.708333333333333 17.3 17 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.2321051018355e-07 6.06673204121769e-07 0.931849271715238 0.707865168539326 17.3 17 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 4.03871530229265e-07 1.84201662665463e-06 0.931127746921034 0.707317073170732 17.3 17 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.83293817221384e-12 2.30820444164628e-11 0.929723028337316 0.70625 17.3 17 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 4.37953500786835e-06 1.72633748371099e-05 0.929239049665616 0.705882352941177 17.3 17 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0209698986793294 0.0375347997744475 0.929239049665616 0.705882352941177 17.3 17 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0209698986793294 0.0375347997744475 0.929239049665616 0.705882352941177 17.3 17 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0209698986793294 0.0375347997744475 0.929239049665616 0.705882352941177 17.3 17 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0209698986793294 0.0375347997744475 0.929239049665616 0.705882352941177 17.3 17 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0209698986793294 0.0375347997744475 0.929239049665616 0.705882352941177 17.3 17 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000231287498323081 0.00067443055351177 0.927479127223067 0.704545454545455 17.3 17 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00394576325372034 0.00858535337927224 0.926371027907388 0.703703703703704 17.3 17 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00394576325372034 0.00858535337927224 0.926371027907388 0.703703703703704 17.3 17 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00394576325372034 0.00858535337927224 0.926371027907388 0.703703703703704 17.3 17 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 6.6749893268134e-07 2.92261840370938e-06 0.926371027907388 0.703703703703704 17.3 17 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 6.6749893268134e-07 2.92261840370938e-06 0.926371027907388 0.703703703703704 17.3 17 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00078735358763587 0.00203709846401062 0.925053288180635 0.702702702702703 17.3 17 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000548595017612395 0.00148695373345226 0.921495390918402 0.7 17.3 17 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00272059270249988 0.00626440682145199 0.921495390918402 0.7 17.3 17 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00272059270249988 0.00626440682145199 0.921495390918402 0.7 17.3 17 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.082229570372935 0.126363583845234 0.921495390918402 0.7 17.3 17 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.06424439451557e-16 2.16345681913664e-15 0.920930402941138 0.699570815450644 17.3 17 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 5.49336775540818e-07 2.45819569683831e-06 0.918433944436946 0.697674418604651 17.3 17 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000382614747589847 0.00106339997230537 0.918433944436946 0.697674418604651 17.3 17 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00188008127528426 0.00448885176968037 0.917506233381959 0.696969696969697 17.3 17 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00188008127528426 0.00448885176968037 0.917506233381959 0.696969696969697 17.3 17 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.74833146414353e-07 1.26976482905073e-06 0.915771817061766 0.695652173913043 17.3 17 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000267099141174266 0.000769396918807654 0.915771817061766 0.695652173913043 17.3 17 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.000267099141174266 0.000769396918807654 0.915771817061766 0.695652173913043 17.3 17 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00961288947182122 0.0192392991819994 0.915771817061766 0.695652173913043 17.3 17 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.6035635941007e-17 6.1747849906755e-16 0.914181935434923 0.694444444444444 17.3 17 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.6035635941007e-17 6.1747849906755e-16 0.914181935434923 0.694444444444444 17.3 17 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.6035635941007e-17 6.1747849906755e-16 0.914181935434923 0.694444444444444 17.3 17 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 8.95771468694196e-07 3.81641556871809e-06 0.913751732171189 0.694117647058824 17.3 17 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 8.95771468694196e-07 3.81641556871809e-06 0.913751732171189 0.694117647058824 17.3 17 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 8.95771468694196e-07 3.81641556871809e-06 0.913751732171189 0.694117647058824 17.3 17 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 8.95771468694196e-07 3.81641556871809e-06 0.913751732171189 0.694117647058824 17.3 17 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 8.95771468694196e-07 3.81641556871809e-06 0.913751732171189 0.694117647058824 17.3 17 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 8.95771468694196e-07 3.81641556871809e-06 0.913751732171189 0.694117647058824 17.3 17 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 8.95771468694196e-07 3.81641556871809e-06 0.913751732171189 0.694117647058824 17.3 17 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000186619535258591 0.000553249163902032 0.913435664467221 0.693877551020408 17.3 17 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 6.32577299237889e-07 2.78686531521831e-06 0.912519786461405 0.693181818181818 17.3 17 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.04493256549837e-18 3.45799776907949e-17 0.91246578162111 0.693140794223827 17.3 17 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 3.57903465586145e-29 2.68050858699518e-27 0.912050210742429 0.692825112107623 17.3 17 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0533779012957739 0.088116883461585 0.911369067941277 0.692307692307692 17.3 17 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0533779012957739 0.088116883461585 0.911369067941277 0.692307692307692 17.3 17 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0533779012957739 0.088116883461585 0.911369067941277 0.692307692307692 17.3 17 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0533779012957739 0.088116883461585 0.911369067941277 0.692307692307692 17.3 17 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0533779012957739 0.088116883461585 0.911369067941277 0.692307692307692 17.3 17 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0533779012957739 0.088116883461585 0.911369067941277 0.692307692307692 17.3 17 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.000436449627083172 0.00121065851723071 0.906868479951443 0.688888888888889 17.3 17 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 4.48055819929505e-05 0.000149667472244058 0.906388909100068 0.688524590163934 17.3 17 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 5.55327940834181e-08 2.88405715258044e-07 0.905794945201575 0.688073394495413 17.3 17 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0352432144143848 0.0602053950920403 0.905040116080574 0.6875 17.3 17 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 8.44959620500685e-48 1.33597504441386e-45 0.903459904028285 0.686299615877081 17.3 17 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.31016778696533e-14 2.04875688005677e-13 0.903195354327454 0.68609865470852 17.3 17 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.5467219080399e-05 5.80734901092553e-05 0.902689362532312 0.685714285714286 17.3 17 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.20026704110579e-23 1.57033793085984e-21 0.901080290584839 0.684491978609626 17.3 17 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00147173249139799 0.00359223899701429 0.900709780596934 0.684210526315789 17.3 17 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0235419851338232 0.0419277157014148 0.900709780596934 0.684210526315789 17.3 17 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0235419851338232 0.0419277157014148 0.900709780596934 0.684210526315789 17.3 17 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0235419851338232 0.0419277157014148 0.900709780596934 0.684210526315789 17.3 17 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00101905381686857 0.00260343551419026 0.899019893578929 0.682926829268293 17.3 17 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.74184697555002e-05 6.4380473927472e-05 0.895898296726224 0.680555555555556 17.3 17 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0107546101933262 0.0209641237056207 0.895166951177876 0.68 17.3 17 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.43224407805078e-37 5.25590276922188e-35 0.892628283582367 0.678071539657854 17.3 17 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.80253390450294e-08 1.51635199471775e-07 0.891769733146841 0.67741935483871 17.3 17 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 5.3870751012663e-12 5.43674316957585e-11 0.89132738704905 0.677083333333333 17.3 17 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000546157221347924 0.00148317123278263 0.88656990962995 0.673469387755102 17.3 17 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000184419963232221 0.000549015915647387 0.885180301621125 0.672413793103448 17.3 17 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000184419963232221 0.000549015915647387 0.885180301621125 0.672413793103448 17.3 17 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000184419963232221 0.000549015915647387 0.885180301621125 0.672413793103448 17.3 17 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.09768244498141e-07 5.50000746200191e-07 0.881241164868838 0.669421487603306 17.3 17 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 9.10824667482083e-31 8.64069001218002e-29 0.880688614788165 0.669001751313485 17.3 17 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00260917812783919 0.00603717150555312 0.877614658017526 0.666666666666667 17.3 17 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00260917812783919 0.00603717150555312 0.877614658017526 0.666666666666667 17.3 17 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00260917812783919 0.00603717150555312 0.877614658017526 0.666666666666667 17.3 17 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.00804306039033683 0.0161428419399849 0.877614658017526 0.666666666666667 17.3 17 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0117891233379403 0.022949278399301 0.877614658017526 0.666666666666667 17.3 17 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0173638321891573 0.0318001714352263 0.877614658017526 0.666666666666667 17.3 17 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0173638321891573 0.0318001714352263 0.877614658017526 0.666666666666667 17.3 17 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0173638321891573 0.0318001714352263 0.877614658017526 0.666666666666667 17.3 17 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0173638321891573 0.0318001714352263 0.877614658017526 0.666666666666667 17.3 17 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0384239491798928 0.0654817720754341 0.877614658017526 0.666666666666667 17.3 17 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0384239491798928 0.0654817720754341 0.877614658017526 0.666666666666667 17.3 17 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.057978845988466 0.0938610896946384 0.877614658017526 0.666666666666667 17.3 17 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0887689906304939 0.135389360843722 0.877614658017526 0.666666666666667 17.3 17 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0887689906304939 0.135389360843722 0.877614658017526 0.666666666666667 17.3 17 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0887689906304939 0.135389360843722 0.877614658017526 0.666666666666667 17.3 17 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0887689906304939 0.135389360843722 0.877614658017526 0.666666666666667 17.3 17 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0887689906304939 0.135389360843722 0.877614658017526 0.666666666666667 17.3 17 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0887689906304939 0.135389360843722 0.877614658017526 0.666666666666667 17.3 17 3 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.138942111401638 0.200116016725234 0.877614658017526 0.666666666666667 17.3 17 3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.138942111401638 0.200116016725234 0.877614658017526 0.666666666666667 17.3 17 3 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.138942111401638 0.200116016725234 0.877614658017526 0.666666666666667 17.3 17 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.138942111401638 0.200116016725234 0.877614658017526 0.666666666666667 17.3 17 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.138942111401638 0.200116016725234 0.877614658017526 0.666666666666667 17.3 17 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.138942111401638 0.200116016725234 0.877614658017526 0.666666666666667 17.3 17 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.59493041805497e-75 1.27889649622305e-72 0.866000003085725 0.657843770174306 17.3 17 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.000709205042125871 0.00183824913469055 0.861658027871753 0.654545454545455 17.3 17 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0186773536188135 0.034030568757454 0.86073745305565 0.653846153846154 17.3 17 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0275735667828541 0.0489852503520616 0.858536078495406 0.652173913043478 17.3 17 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0409755192431479 0.0690037442402361 0.855674291567088 0.65 17.3 17 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0614109599286531 0.0993043136119015 0.851802462193481 0.647058823529412 17.3 17 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00225808813631068 0.00525042388557205 0.850189199954478 0.645833333333333 17.3 17 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00225808813631068 0.00525042388557205 0.850189199954478 0.645833333333333 17.3 17 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0135446310559376 0.0262588691997265 0.849304507758896 0.645161290322581 17.3 17 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.019815048578559 0.0360573070681451 0.846271277374043 0.642857142857143 17.3 17 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0930951132311332 0.140630940687795 0.846271277374043 0.642857142857143 17.3 17 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0930951132311332 0.140630940687795 0.846271277374043 0.642857142857143 17.3 17 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0930951132311332 0.140630940687795 0.846271277374043 0.642857142857143 17.3 17 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0930951132311332 0.140630940687795 0.846271277374043 0.642857142857143 17.3 17 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0930951132311332 0.140630940687795 0.846271277374043 0.642857142857143 17.3 17 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0930951132311332 0.140630940687795 0.846271277374043 0.642857142857143 17.3 17 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0930951132311332 0.140630940687795 0.846271277374043 0.642857142857143 17.3 17 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0930951132311332 0.140630940687795 0.846271277374043 0.642857142857143 17.3 17 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00166943050864084 0.00400607017503528 0.844497123752714 0.641509433962264 17.3 17 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00678470616006211 0.0137334806056449 0.843860248093775 0.641025641025641 17.3 17 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00982921132779759 0.0196446175835056 0.841047380600129 0.638888888888889 17.3 17 3 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.143429582765987 0.206161915430303 0.837723082653093 0.636363636363636 17.3 17 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.143429582765987 0.206161915430303 0.837723082653093 0.636363636363636 17.3 17 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0142752630918415 0.0270849325062539 0.837723082653093 0.636363636363636 17.3 17 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0142752630918415 0.0270849325062539 0.837723082653093 0.636363636363636 17.3 17 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0639358875445836 0.103269884195167 0.831424412858709 0.631578947368421 17.3 17 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.39998349654011e-06 5.85934269287227e-06 0.830933027271913 0.631205673758865 17.3 17 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00264950833043589 0.00612053628930238 0.828858288127663 0.62962962962963 17.3 17 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0303873450962978 0.0533841877432491 0.828858288127663 0.62962962962963 17.3 17 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.69052500080238e-08 9.66111275558952e-08 0.828610793864263 0.629441624365482 17.3 17 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 2.77004522068576e-05 9.77216179886989e-05 0.825755610043763 0.627272727272727 17.3 17 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0958715652786012 0.144365330572962 0.822763741891431 0.625 17.3 17 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0958715652786012 0.144365330572962 0.822763741891431 0.625 17.3 17 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.226528897785449 0.300700206668557 0.822763741891431 0.625 17.3 17 3 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.226528897785449 0.300700206668557 0.822763741891431 0.625 17.3 17 3 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.226528897785449 0.300700206668557 0.822763741891431 0.625 17.3 17 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.226528897785449 0.300700206668557 0.822763741891431 0.625 17.3 17 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0020202304890202 0.00477539532537498 0.820066155852442 0.622950819672131 17.3 17 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.00394127665578157 0.00858535337927224 0.819658973054105 0.622641509433962 17.3 17 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00776009663641172 0.015663287253353 0.819107014149691 0.622222222222222 17.3 17 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00408253265815581 0.00885585971426177 0.813788137434433 0.618181818181818 17.3 17 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.022325575431437 0.0399111731644911 0.813084168457414 0.617647058823529 17.3 17 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000582731537107 0.00155961481284477 0.812606164831042 0.617283950617284 17.3 17 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0458114906824382 0.0770564435474108 0.810105838170024 0.615384615384615 17.3 17 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.145394733566046 0.208565227685972 0.810105838170024 0.615384615384615 17.3 17 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0322677506781213 0.0563398886073209 0.806839282370951 0.612903225806452 17.3 17 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0975334053909907 0.14655758803736 0.804480103182732 0.611111111111111 17.3 17 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0975334053909907 0.14655758803736 0.804480103182732 0.611111111111111 17.3 17 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 4.48217736481711e-06 1.76191668235766e-05 0.801300339929045 0.608695652173913 17.3 17 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0670012901625404 0.107976031598296 0.801300339929045 0.608695652173913 17.3 17 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0670012901625404 0.107976031598296 0.801300339929045 0.608695652173913 17.3 17 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000185648137188556 0.000551518369977692 0.799695599595409 0.607476635514019 17.3 17 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0329305202201309 0.0573563406037286 0.79783150728866 0.606060606060606 17.3 17 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0329305202201309 0.0573563406037286 0.79783150728866 0.606060606060606 17.3 17 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 8.85641961589885e-06 3.36970190198504e-05 0.796561074952213 0.605095541401274 17.3 17 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 6.54772970977122e-06 2.55271763753546e-05 0.796354041534422 0.604938271604938 17.3 17 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0119971647724695 0.0233223572011258 0.795338283828383 0.604166666666667 17.3 17 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000684746866596015 0.00179446554542565 0.792684207241636 0.602150537634409 17.3 17 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.098376439996737 0.147512828361809 0.789853192215773 0.6 17.3 17 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.098376439996737 0.147512828361809 0.789853192215773 0.6 17.3 17 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.224010922944693 0.300700206668557 0.789853192215773 0.6 17.3 17 3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.224010922944693 0.300700206668557 0.789853192215773 0.6 17.3 17 3 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.224010922944693 0.300700206668557 0.789853192215773 0.6 17.3 17 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.224010922944693 0.300700206668557 0.789853192215773 0.6 17.3 17 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0473834747356012 0.0792322967670512 0.789853192215773 0.6 17.3 17 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00646967081233899 0.0133425240086353 0.785606669676979 0.596774193548387 17.3 17 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00655751149576577 0.0135041083335379 0.781625554796859 0.59375 17.3 17 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0478235576849038 0.0796872629808175 0.781625554796859 0.59375 17.3 17 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0478235576849038 0.0796872629808175 0.781625554796859 0.59375 17.3 17 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00189179071084068 0.00450924318513616 0.777885719606443 0.590909090909091 17.3 17 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.145101001492813 0.208353910317127 0.774365874721346 0.588235294117647 17.3 17 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.47933310207019e-12 1.87954553950525e-11 0.77389656207 0.587878787878788 17.3 17 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 6.9016449188118e-05 0.000224737773900897 0.772867102060595 0.587096774193548 17.3 17 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0683979272050116 0.109853555770577 0.771695647567135 0.586206896551724 17.3 17 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.024564599366805 0.0436942811237044 0.767912825765335 0.583333333333333 17.3 17 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.219954411755678 0.296677846377563 0.767912825765335 0.583333333333333 17.3 17 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000583074547036836 0.00155961481284477 0.766114435072676 0.581967213114754 17.3 17 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 5.35328356673032e-05 0.000177156337568773 0.765361620364121 0.581395348837209 17.3 17 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0683129388151889 0.109841030433914 0.764374056983006 0.580645161290323 17.3 17 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0683129388151889 0.109841030433914 0.764374056983006 0.580645161290323 17.3 17 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00683791921815233 0.0138215327378278 0.762139045120483 0.578947368421053 17.3 17 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000132354419414678 0.000410327535570994 0.761703288090683 0.578616352201258 17.3 17 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000132354419414678 0.000410327535570994 0.761703288090683 0.578616352201258 17.3 17 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.94606824866835e-06 1.58623025928109e-05 0.75371611806211 0.572549019607843 17.3 17 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0477778898027907 0.0796872629808175 0.752241135443594 0.571428571428571 17.3 17 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.215127560679263 0.293789305861823 0.752241135443594 0.571428571428571 17.3 17 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.215127560679263 0.293789305861823 0.752241135443594 0.571428571428571 17.3 17 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.215127560679263 0.293789305861823 0.752241135443594 0.571428571428571 17.3 17 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.215127560679263 0.293789305861823 0.752241135443594 0.571428571428571 17.3 17 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000243026697623046 0.000704424112343967 0.751087391370827 0.570552147239264 17.3 17 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.209924019716391 0.290585486436211 0.740487367702288 0.5625 17.3 17 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.209924019716391 0.290585486436211 0.740487367702288 0.5625 17.3 17 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00185715358191947 0.00444903964153436 0.733435107057504 0.557142857142857 17.3 17 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.134728484010834 0.195232823571708 0.731345548347938 0.555555555555556 17.3 17 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.336012380765212 0.436662664683924 0.731345548347938 0.555555555555556 17.3 17 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.00439534548286921 0.00943375056127131 0.725586921982994 0.551181102362205 17.3 17 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.199162112070211 0.276225814304006 0.724032092864459 0.55 17.3 17 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.199162112070211 0.276225814304006 0.724032092864459 0.55 17.3 17 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.199162112070211 0.276225814304006 0.724032092864459 0.55 17.3 17 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.003112099428196 0.00694124997856255 0.723105035127116 0.549295774647887 17.3 17 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00413860820827387 0.00896383482553078 0.720668970999793 0.547445255474453 17.3 17 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.126601498925993 0.184773264586346 0.718048356559794 0.545454545454545 17.3 17 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.193803283661768 0.269581693695695 0.718048356559794 0.545454545454545 17.3 17 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.320708531159141 0.417155612284696 0.718048356559794 0.545454545454545 17.3 17 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.320708531159141 0.417155612284696 0.718048356559794 0.545454545454545 17.3 17 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.320708531159141 0.417155612284696 0.718048356559794 0.545454545454545 17.3 17 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.320708531159141 0.417155612284696 0.718048356559794 0.545454545454545 17.3 17 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.320708531159141 0.417155612284696 0.718048356559794 0.545454545454545 17.3 17 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.320708531159141 0.417155612284696 0.718048356559794 0.545454545454545 17.3 17 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.320708531159141 0.417155612284696 0.718048356559794 0.545454545454545 17.3 17 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.320708531159141 0.417155612284696 0.718048356559794 0.545454545454545 17.3 17 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00534904149870456 0.0114633826094226 0.716288434117245 0.544117647058823 17.3 17 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0839689083125898 0.128897256233889 0.715446732079505 0.543478260869565 17.3 17 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.121093410699936 0.176915732470235 0.711579452446643 0.540540540540541 17.3 17 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00677082028428983 0.0137248963882399 0.711060051386463 0.54014598540146 17.3 17 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0806975150567048 0.125226351064003 0.710867872994196 0.54 17.3 17 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.306940702976915 0.402188416515792 0.708842608398771 0.538461538461538 17.3 17 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.115662365112729 0.169154723078534 0.706372773526301 0.536585365853659 17.3 17 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.115662365112729 0.169154723078534 0.706372773526301 0.536585365853659 17.3 17 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0518313109702292 0.0861634994283133 0.705907442318445 0.536231884057971 17.3 17 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.178330240360674 0.2547830642904 0.705226064478369 0.535714285714286 17.3 17 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.173430504466585 0.248031766689398 0.702091726414021 0.533333333333333 17.3 17 3 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.294393899632553 0.386459888539781 0.702091726414021 0.533333333333333 17.3 17 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.294393899632553 0.386459888539781 0.702091726414021 0.533333333333333 17.3 17 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.294393899632553 0.386459888539781 0.702091726414021 0.533333333333333 17.3 17 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00108040680247969 0.00275523096761399 0.697862258182611 0.530120481927711 17.3 17 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.282849915217916 0.373026347873119 0.696929287249212 0.529411764705882 17.3 17 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.272149945720414 0.359581590306545 0.692853677382257 0.526315789473684 17.3 17 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.262173965861546 0.346722633290874 0.689554374156627 0.523809523809524 17.3 17 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0498813672967696 0.0830189306003545 0.686219971960512 0.521276595744681 17.3 17 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.244038996635037 0.323039527638751 0.68453943325367 0.52 17.3 17 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.244038996635037 0.323039527638751 0.68453943325367 0.52 17.3 17 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0102490862334548 0.0203978317625261 0.683116274348777 0.518918918918919 17.3 17 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.23574473272866 0.312641896246862 0.682589178458076 0.518518518518518 17.3 17 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.157531661887914 0.225747789392247 0.670630068862449 0.509433962264151 17.3 17 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.101928090541656 0.152517006141722 0.665954652260358 0.505882352941176 17.3 17 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.101928090541656 0.152517006141722 0.665954652260358 0.505882352941176 17.3 17 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0896212026440435 0.1365427958913 0.665139530286967 0.505263157894737 17.3 17 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.378863779548715 0.480501923616596 0.658210993513144 0.5 17.3 17 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.378863779548715 0.480501923616596 0.658210993513144 0.5 17.3 17 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.282360426790047 0.372726240558662 0.658210993513144 0.5 17.3 17 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.293159225096647 0.386264423437526 0.658210993513144 0.5 17.3 17 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.345137779370616 0.448112281062397 0.658210993513144 0.5 17.3 17 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.361139333815742 0.4642287913458 0.658210993513144 0.5 17.3 17 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.361139333815742 0.4642287913458 0.658210993513144 0.5 17.3 17 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.398753845274567 0.49730650466758 0.658210993513144 0.5 17.3 17 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.421462650562604 0.523334512871366 0.658210993513144 0.5 17.3 17 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.421462650562604 0.523334512871366 0.658210993513144 0.5 17.3 17 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.421462650562604 0.523334512871366 0.658210993513144 0.5 17.3 17 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.421462650562604 0.523334512871366 0.658210993513144 0.5 17.3 17 3 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.448013838585731 0.542111983254672 0.658210993513144 0.5 17.3 17 3 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.448013838585731 0.542111983254672 0.658210993513144 0.5 17.3 17 3 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.448013838585731 0.542111983254672 0.658210993513144 0.5 17.3 17 3 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.448013838585731 0.542111983254672 0.658210993513144 0.5 17.3 17 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.293702071376643 0.386459888539781 0.641333788551269 0.487179487179487 17.3 17 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.304349545723969 0.399160740613094 0.640421507201978 0.486486486486487 17.3 17 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.171091509772226 0.244932815297663 0.637853952476655 0.484536082474227 17.3 17 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.354072067267088 0.455967920109563 0.635514062702346 0.482758620689655 17.3 17 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.112057968367694 0.166579591339875 0.634130103506566 0.481707317073171 17.3 17 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.180529278181817 0.257666161336737 0.632895186070331 0.480769230769231 17.3 17 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.384595003282568 0.487336322057964 0.631882553772619 0.48 17.3 17 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0933932982279435 0.140931774526366 0.624655138941886 0.474509803921569 17.3 17 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.464209436731646 0.560279922365677 0.619492699777077 0.470588235294118 17.3 17 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.519624319921767 0.620633434625287 0.607579378627518 0.461538461538462 17.3 17 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.519624319921767 0.620633434625287 0.607579378627518 0.461538461538462 17.3 17 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.519624319921767 0.620633434625287 0.607579378627518 0.461538461538462 17.3 17 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.407905039434411 0.508273967701548 0.603360077387049 0.458333333333333 17.3 17 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.444047329149575 0.53914620254253 0.601792908354875 0.457142857142857 17.3 17 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.461335553591734 0.55775742800428 0.598373630466495 0.454545454545455 17.3 17 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.495571744643476 0.595606919449043 0.598373630466495 0.454545454545455 17.3 17 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.554101594774554 0.657072141136826 0.598373630466495 0.454545454545455 17.3 17 3 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.554101594774554 0.657072141136826 0.598373630466495 0.454545454545455 17.3 17 3 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.554101594774554 0.657072141136826 0.598373630466495 0.454545454545455 17.3 17 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.554101594774554 0.657072141136826 0.598373630466495 0.454545454545455 17.3 17 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.479751696089141 0.577557941332422 0.594513155431227 0.451612903225806 17.3 17 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.519850513426836 0.620633434625287 0.59238989416183 0.45 17.3 17 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.54666551906437 0.650422268920233 0.585076438678351 0.444444444444444 17.3 17 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.129769623459225 0.188879170839272 0.584362930826304 0.44390243902439 17.3 17 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.462147299732137 0.558264522511741 0.583224930961014 0.443037974683544 17.3 17 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.508957353920817 0.611178324581706 0.577378064485214 0.43859649122807 17.3 17 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.576561589615585 0.675065255841841 0.575934619324001 0.4375 17.3 17 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.576561589615585 0.675065255841841 0.575934619324001 0.4375 17.3 17 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.576561589615585 0.675065255841841 0.575934619324001 0.4375 17.3 17 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.562597178173627 0.66659099462204 0.570449527711392 0.433333333333333 17.3 17 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.610277175907166 0.707762364560633 0.564180851582695 0.428571428571429 17.3 17 3 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.610277175907166 0.707762364560633 0.564180851582695 0.428571428571429 17.3 17 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.609307219834314 0.707762364560633 0.556947763741891 0.423076923076923 17.3 17 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.622430026345756 0.721268670594471 0.552047930043282 0.419354838709677 17.3 17 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.625742584701702 0.724517248194079 0.551060366662167 0.418604651162791 17.3 17 3 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.64884369778309 0.748220892986497 0.548509161260954 0.416666666666667 17.3 17 3 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.64884369778309 0.748220892986497 0.548509161260954 0.416666666666667 17.3 17 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.645750648655939 0.747075750436912 0.544726339459154 0.413793103448276 17.3 17 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.695453124650227 0.782934965488349 0.537693487658625 0.408450704225352 17.3 17 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.752723717897459 0.840758124464744 0.522389677391384 0.396825396825397 17.3 17 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.777114315835167 0.863932555807377 0.510449341908153 0.387755102040816 17.3 17 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.975374681622999 1 0.505533185739477 0.384020618556701 17.3 17 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.856611047729523 0.9362192941007 0.505293287949485 0.383838383838384 17.3 17 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.773394159319892 0.861319255064562 0.503337818568875 0.382352941176471 17.3 17 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.776927808201841 0.863932555807377 0.493658245134858 0.375 17.3 17 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.982864826279288 1 0.488956738038336 0.371428571428571 17.3 17 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.975031716008136 1 0.485316861576512 0.368663594470046 17.3 17 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.868443952574677 0.948423441683627 0.476152633605253 0.361702127659574 17.3 17 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.895266830794562 0.969271735392169 0.47477514286194 0.360655737704918 17.3 17 3 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.795899493968223 0.884125667382343 0.470150709652246 0.357142857142857 17.3 17 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.934560470921531 0.997659077360344 0.466579944768811 0.354430379746835 17.3 17 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.846939696524851 0.926360636552546 0.457885908530883 0.347826086956522 17.3 17 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.871757333192256 0.951311875101672 0.438807329008763 0.333333333333333 17.3 17 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.998538069583144 1 0.431729791444106 0.327956989247312 17.3 17 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.922341373529015 0.987569814699049 0.424652253879448 0.32258064516129 17.3 17 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.922341373529015 0.987569814699049 0.424652253879448 0.32258064516129 17.3 17 3 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.903337827085296 0.976043832909928 0.418861541326546 0.318181818181818 17.3 17 3 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.903337827085296 0.976043832909928 0.418861541326546 0.318181818181818 17.3 17 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.932189731348315 0.995875366147636 0.405052919085012 0.307692307692308 17.3 17 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999756008640369 1 0.403902200564884 0.306818181818182 17.3 17 3 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.923999069281554 0.987866773544441 0.394926596107887 0.3 17.3 17 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.920475393480786 0.987569814699049 0.387182937360673 0.294117647058824 17.3 17 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.960294229535069 1 0.346426838691129 0.263157894736842 17.3 17 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.989800900794441 1 0.346426838691129 0.263157894736842 17.3 17 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.340434905125186 0.258606213266163 17.3 17 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.989789049802854 1 0.329105496756572 0.25 17.3 17 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999989029369397 1 0.316916404284107 0.240740740740741 17.3 17 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.998986734714788 1 0.301680038693524 0.229166666666667 17.3 17 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.99999070082415 1 0.292538219339175 0.222222222222222 17.3 17 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.288041700597072 0.21880650994575 17.3 17 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.998938841833561 1 0.263284397405258 0.2 17.3 17 3 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999992738882771 1 0.196062849131575 0.148936170212766 17.3 17 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0233558739633696 0.017741935483871 17.3 17 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 3.04226058199846e-09 6.76427626278721e-08 4.85343322974756 0.923076923076923 17.1 17 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 1.82535103797664e-05 0.000151899095148582 4.60065024903154 0.875 17.1 17 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.000541162474938995 0.00324925823560418 4.38157166574433 0.833333333333333 17.1 17 1 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.000541162474938995 0.00324925823560418 4.38157166574433 0.833333333333333 17.1 17 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00034672699848517 0.00227369824352257 3.94341449916989 0.75 17.1 17 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 4.41859615564701e-05 0.000349149430910422 3.82391709010414 0.727272727272727 17.1 17 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 4.41859615564701e-05 0.000349149430910422 3.82391709010414 0.727272727272727 17.1 17 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00164313895627119 0.00756694736172784 3.75563285635228 0.714285714285714 17.1 17 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00164313895627119 0.00756694736172784 3.75563285635228 0.714285714285714 17.1 17 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 3.41557249913586e-06 3.30636711991179e-05 3.61479662423907 0.6875 17.1 17 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 1.48254417047341e-05 0.000127087973167691 3.50525733259546 0.666666666666667 17.1 17 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000113870467891065 0.000822526273142056 3.50525733259546 0.666666666666667 17.1 17 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 8.42701750226785e-08 1.2894242909384e-06 3.36504703929164 0.64 17.1 17 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000480685899370491 0.0029739827600183 3.34592745384112 0.636363636363636 17.1 17 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000480685899370491 0.0029739827600183 3.34592745384112 0.636363636363636 17.1 17 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.000480685899370491 0.0029739827600183 3.34592745384112 0.636363636363636 17.1 17 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000480685899370491 0.0029739827600183 3.34592745384112 0.636363636363636 17.1 17 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00380382555258122 0.0151196753109583 3.28617874930825 0.625 17.1 17 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00380382555258122 0.0151196753109583 3.28617874930825 0.625 17.1 17 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00380382555258122 0.0151196753109583 3.28617874930825 0.625 17.1 17 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00380382555258122 0.0151196753109583 3.28617874930825 0.625 17.1 17 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00380382555258122 0.0151196753109583 3.28617874930825 0.625 17.1 17 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00380382555258122 0.0151196753109583 3.28617874930825 0.625 17.1 17 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.48200037863518e-06 2.54092556748047e-05 3.25488180883864 0.619047619047619 17.1 17 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.000254418149846452 0.00173223458005503 3.23562215316504 0.615384615384615 17.1 17 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000133973401452403 0.000953220751333847 3.15473159933592 0.6 17.1 17 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00194259611668489 0.00877560086997651 3.15473159933592 0.6 17.1 17 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00194259611668489 0.00877560086997651 3.15473159933592 0.6 17.1 17 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 7.03717771614247e-05 0.000521557494274517 3.092874116996 0.588235294117647 17.1 17 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.23334059087123e-12 1.17705320770732e-10 3.07536728237149 0.584905660377358 17.1 17 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.75002420955054e-06 2.73656255258071e-05 3.06710016602103 0.583333333333333 17.1 17 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 2.75002420955054e-06 2.73656255258071e-05 3.06710016602103 0.583333333333333 17.1 17 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.000994227503441687 0.00544148360537508 3.06710016602103 0.583333333333333 17.1 17 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000994227503441687 0.00544148360537508 3.06710016602103 0.583333333333333 17.1 17 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 6.51604323570901e-16 7.13256117262609e-14 3.02508509525362 0.575342465753425 17.1 17 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000510329515503318 0.00313016767483285 3.00450628508182 0.571428571428571 17.1 17 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000510329515503318 0.00313016767483285 3.00450628508182 0.571428571428571 17.1 17 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 4.0943627717561e-07 4.77563788869584e-06 2.97946873270614 0.566666666666667 17.1 17 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 1.01554963523675e-05 8.97594491268261e-05 2.97184860807007 0.565217391304348 17.1 17 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00743512452621231 0.0271503920911238 2.92104777716289 0.555555555555556 17.1 17 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 7.01714554253289e-05 0.000521557494274517 2.89183729939126 0.55 17.1 17 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.00369688837746218 0.0149876699747256 2.86793781757811 0.545454545454545 17.1 17 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 2.13131539293928e-07 2.82293469670498e-06 2.85428097082773 0.542857142857143 17.1 17 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 9.84097382761691e-06 8.75231609793679e-05 2.83116938401941 0.538461538461538 17.1 17 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 9.84097382761691e-06 8.75231609793679e-05 2.83116938401941 0.538461538461538 17.1 17 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.67783796036494e-06 2.70252724652433e-05 2.80420586607637 0.533333333333333 17.1 17 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00094045078870436 0.00520724308298173 2.80420586607637 0.533333333333333 17.1 17 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 7.32293369836856e-07 7.9546066051744e-06 2.7835867052964 0.529411764705882 17.1 17 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.5301253737735e-08 2.59210524628535e-07 2.74324486898775 0.521739130434783 17.1 17 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 6.50083147943128e-05 0.00048687806290688 2.74324486898775 0.521739130434783 17.1 17 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 2.45595721289318e-06 2.53248341590362e-05 2.70860793882377 0.515151515151515 17.1 17 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 1.28199413158819e-06 1.36140123078358e-05 2.70405565657364 0.514285714285714 17.1 17 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 6.70035461097207e-07 7.39116636543664e-06 2.69999551294515 0.513513513513513 17.1 17 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.83627719110908e-07 2.66634943157981e-06 2.69306356040871 0.51219512195122 17.1 17 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.32651909275602e-09 1.34079207692408e-07 2.68049090139653 0.509803921568627 17.1 17 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.32651909275602e-09 1.34079207692408e-07 2.68049090139653 0.509803921568627 17.1 17 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.21240528252475e-11 5.07427269715508e-10 2.66597036563599 0.507042253521127 17.1 17 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 8.57168962882832e-08 1.29760790870454e-06 2.6289429994466 0.5 17.1 17 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000822587691946999 0.00462664935035802 2.6289429994466 0.5 17.1 17 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00161818766172132 0.00756080700103354 2.6289429994466 0.5 17.1 17 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00161818766172132 0.00756080700103354 2.6289429994466 0.5 17.1 17 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00161818766172132 0.00756080700103354 2.6289429994466 0.5 17.1 17 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00161818766172132 0.00756080700103354 2.6289429994466 0.5 17.1 17 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00639954925148267 0.0237769153651693 2.6289429994466 0.5 17.1 17 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00639954925148267 0.0237769153651693 2.6289429994466 0.5 17.1 17 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00639954925148267 0.0237769153651693 2.6289429994466 0.5 17.1 17 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00639954925148267 0.0237769153651693 2.6289429994466 0.5 17.1 17 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00639954925148267 0.0237769153651693 2.6289429994466 0.5 17.1 17 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 6.5890263600323e-14 4.07660196101129e-12 2.6289429994466 0.5 17.1 17 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 1.242200750145e-08 2.17815855527966e-07 2.6289429994466 0.5 17.1 17 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 5.95685636453055e-07 6.78128528538158e-06 2.6289429994466 0.5 17.1 17 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 4.17962105594949e-06 3.9916783641719e-05 2.6289429994466 0.5 17.1 17 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 1.5429002454607e-05 0.000131469883191053 2.6289429994466 0.5 17.1 17 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 5.73968415800474e-05 0.00044149030036977 2.6289429994466 0.5 17.1 17 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 5.73968415800474e-05 0.00044149030036977 2.6289429994466 0.5 17.1 17 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.000215730793590222 0.00149021805475187 2.6289429994466 0.5 17.1 17 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00320434731643561 0.0132551925328136 2.6289429994466 0.5 17.1 17 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00320434731643561 0.0132551925328136 2.6289429994466 0.5 17.1 17 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0129276529357397 0.0424851042206873 2.6289429994466 0.5 17.1 17 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0129276529357397 0.0424851042206873 2.6289429994466 0.5 17.1 17 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0129276529357397 0.0424851042206873 2.6289429994466 0.5 17.1 17 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0129276529357397 0.0424851042206873 2.6289429994466 0.5 17.1 17 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.94449543369058e-09 9.50813108397527e-08 2.54131156613171 0.483333333333333 17.1 17 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.94449543369058e-09 9.50813108397527e-08 2.54131156613171 0.483333333333333 17.1 17 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.94449543369058e-09 9.50813108397527e-08 2.54131156613171 0.483333333333333 17.1 17 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.94449543369058e-09 9.50813108397527e-08 2.54131156613171 0.483333333333333 17.1 17 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.94449543369058e-09 9.50813108397527e-08 2.54131156613171 0.483333333333333 17.1 17 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.94449543369058e-09 9.50813108397527e-08 2.54131156613171 0.483333333333333 17.1 17 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.94449543369058e-09 9.50813108397527e-08 2.54131156613171 0.483333333333333 17.1 17 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.56861181920877e-11 9.87874221279481e-10 2.5291097209866 0.481012658227848 17.1 17 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.56861181920877e-11 9.87874221279481e-10 2.5291097209866 0.481012658227848 17.1 17 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.02290769175442e-14 1.37076078350787e-12 2.52782980716019 0.480769230769231 17.1 17 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000182638722913634 0.00127399462110834 2.52378527946873 0.48 17.1 17 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000182638722913634 0.00127399462110834 2.52378527946873 0.48 17.1 17 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.08350822462729e-16 1.40166563967693e-14 2.52207539784308 0.479674796747967 17.1 17 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.32103555526692e-07 2.82293469670498e-06 2.51940370780299 0.479166666666667 17.1 17 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000353893065819803 0.0022994969527926 2.51464112990544 0.478260869565217 17.1 17 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000353893065819803 0.0022994969527926 2.51464112990544 0.478260869565217 17.1 17 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.13894015233211e-11 1.51018252224836e-09 2.49749584947427 0.475 17.1 17 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.05723787834256e-06 3.02114548672324e-05 2.49749584947427 0.475 17.1 17 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 5.83647996815068e-06 5.35826515785705e-05 2.49057757842309 0.473684210526316 17.1 17 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 6.59580047666695e-11 2.28922538495051e-09 2.46666256738199 0.469135802469136 17.1 17 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 6.59580047666695e-11 2.28922538495051e-09 2.46666256738199 0.469135802469136 17.1 17 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.244003872013e-10 3.93381668861e-09 2.46255420201327 0.468354430379747 17.1 17 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.05017109317881e-07 7.71722574276419e-06 2.46113812714149 0.468085106382979 17.1 17 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 8.3447429152491e-16 7.42160573024967e-14 2.45933377367585 0.467741935483871 17.1 17 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 8.3447429152491e-16 7.42160573024967e-14 2.45933377367585 0.467741935483871 17.1 17 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 8.3447429152491e-16 7.42160573024967e-14 2.45933377367585 0.467741935483871 17.1 17 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00518525677820044 0.0198350010628474 2.45368013281682 0.466666666666667 17.1 17 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00518525677820044 0.0198350010628474 2.45368013281682 0.466666666666667 17.1 17 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.000150657804959435 0.00106659729580734 2.44116135662898 0.464285714285714 17.1 17 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.84420180891377e-06 4.51705780456279e-05 2.43658131656026 0.463414634146341 17.1 17 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.84420180891377e-06 4.51705780456279e-05 2.43658131656026 0.463414634146341 17.1 17 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.67097357824852e-12 1.80130875925781e-10 2.43523141001369 0.463157894736842 17.1 17 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.67097357824852e-12 1.80130875925781e-10 2.43523141001369 0.463157894736842 17.1 17 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.60573689042935e-09 1.06359514601079e-07 2.43275322336849 0.462686567164179 17.1 17 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 4.60148827120689e-13 2.61916712397096e-11 2.42671661487378 0.461538461538462 17.1 17 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0102928728247797 0.0358111443268008 2.42671661487378 0.461538461538462 17.1 17 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0102928728247797 0.0358111443268008 2.42671661487378 0.461538461538462 17.1 17 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 8.6319448910991e-11 2.79164945000773e-09 2.41244181125688 0.458823529411765 17.1 17 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 8.6319448910991e-11 2.79164945000773e-09 2.41244181125688 0.458823529411765 17.1 17 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 8.6319448910991e-11 2.79164945000773e-09 2.41244181125688 0.458823529411765 17.1 17 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000559325557841005 0.00331633445336563 2.40986441615938 0.458333333333333 17.1 17 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000559325557841005 0.00331633445336563 2.40986441615938 0.458333333333333 17.1 17 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 2.53198549725372e-07 3.05340284965427e-06 2.38994818131509 0.454545454545455 17.1 17 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0206199567343043 0.0629660910577576 2.38994818131509 0.454545454545455 17.1 17 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0206199567343043 0.0629660910577576 2.38994818131509 0.454545454545455 17.1 17 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0206199567343043 0.0629660910577576 2.38994818131509 0.454545454545455 17.1 17 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0206199567343043 0.0629660910577576 2.38994818131509 0.454545454545455 17.1 17 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0206199567343043 0.0629660910577576 2.38994818131509 0.454545454545455 17.1 17 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0206199567343043 0.0629660910577576 2.38994818131509 0.454545454545455 17.1 17 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.02462175649994e-09 4.80172793249903e-08 2.38357498616491 0.453333333333333 17.1 17 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.02462175649994e-09 4.80172793249903e-08 2.38357498616491 0.453333333333333 17.1 17 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.02462175649994e-09 4.80172793249903e-08 2.38357498616491 0.453333333333333 17.1 17 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.02462175649994e-09 4.80172793249903e-08 2.38357498616491 0.453333333333333 17.1 17 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.02462175649994e-09 4.80172793249903e-08 2.38357498616491 0.453333333333333 17.1 17 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 3.09243844168733e-08 4.88948878057897e-07 2.38247959324848 0.453125 17.1 17 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.80385406264338e-09 8.20133989566899e-08 2.37685257484213 0.452054794520548 17.1 17 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.11562795038832e-11 1.16672067721121e-09 2.37452916079047 0.451612903225806 17.1 17 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00209639804105625 0.00935164392609107 2.36604869950194 0.45 17.1 17 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.83623460200801e-10 1.16148124226753e-08 2.35058432891696 0.447058823529412 17.1 17 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.21541336401339e-06 3.14831851886638e-05 2.34926821227143 0.446808510638298 17.1 17 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 5.1348264769526e-05 0.000399281862114948 2.33683822173031 0.444444444444444 17.1 17 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000446371356599254 0.00283565375196758 2.33683822173031 0.444444444444444 17.1 17 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000446371356599254 0.00283565375196758 2.33683822173031 0.444444444444444 17.1 17 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000446371356599254 0.00283565375196758 2.33683822173031 0.444444444444444 17.1 17 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00407720978184824 0.0160272638662156 2.33683822173031 0.444444444444444 17.1 17 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00407720978184824 0.0160272638662156 2.33683822173031 0.444444444444444 17.1 17 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 9.74767054791217e-05 0.000707700774983623 2.319655587747 0.441176470588235 17.1 17 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 4.91860036987937e-14 3.18144014833561e-12 2.30538078413009 0.438461538461538 17.1 17 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 4.85671007799091e-06 4.51705780456279e-05 2.30032512451577 0.4375 17.1 17 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00795964386879534 0.0284587266967231 2.30032512451577 0.4375 17.1 17 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00795964386879534 0.0284587266967231 2.30032512451577 0.4375 17.1 17 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 1.09919588110653e-06 1.17605694647714e-05 2.29435025406248 0.436363636363636 17.1 17 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.03057425838954e-09 6.76427626278721e-08 2.28052886698982 0.433734939759036 17.1 17 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.06876338098547e-07 1.59766583333116e-06 2.27580140250601 0.432835820895522 17.1 17 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 8.70699923406912e-12 3.99679351938076e-10 2.27368043195381 0.432432432432432 17.1 17 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 6.48173557456509e-22 1.0248344136229e-19 2.26348455557734 0.430493273542601 17.1 17 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.41747475113257e-09 5.63945339485516e-08 2.26211374370986 0.430232558139535 17.1 17 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000668156520329118 0.00382240434821156 2.25337971381137 0.428571428571429 17.1 17 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00315277307404035 0.0131181172057293 2.25337971381137 0.428571428571429 17.1 17 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0156092669560378 0.0496912458130689 2.25337971381137 0.428571428571429 17.1 17 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0156092669560378 0.0496912458130689 2.25337971381137 0.428571428571429 17.1 17 1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.0156092669560378 0.0496912458130689 2.25337971381137 0.428571428571429 17.1 17 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0156092669560378 0.0496912458130689 2.25337971381137 0.428571428571429 17.1 17 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0156092669560378 0.0496912458130689 2.25337971381137 0.428571428571429 17.1 17 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 6.04870846545057e-05 0.000457835752464689 2.23460154952961 0.425 17.1 17 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000274429843593124 0.00184204560109913 2.23061830256075 0.424242424242424 17.1 17 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 5.67999241385447e-06 5.24846052267202e-05 2.22449023030097 0.423076923076923 17.1 17 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00126985069608867 0.00664337331078744 2.22449023030097 0.423076923076923 17.1 17 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.5255166998575e-05 0.0002077346973351 2.21999631064379 0.422222222222222 17.1 17 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00606632293870557 0.0230196734447414 2.21384673637608 0.421052631578947 17.1 17 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.30914377049735e-07 2.82293469670498e-06 2.20983614446236 0.420289855072464 17.1 17 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00241357115205936 0.0105030940348027 2.19078583287216 0.416666666666667 17.1 17 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00241357115205936 0.0105030940348027 2.19078583287216 0.416666666666667 17.1 17 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0307773906506055 0.0843857936335484 2.19078583287216 0.416666666666667 17.1 17 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 3.34170159815116e-07 3.92995154890008e-06 2.17826705668432 0.414285714285714 17.1 17 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 4.60325585190672e-09 9.50813108397527e-08 2.15850056796668 0.410526315789474 17.1 17 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.98513308813426e-08 3.17398245439894e-07 2.15095336318358 0.409090909090909 17.1 17 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00458682089454124 0.0178334593795961 2.15095336318358 0.409090909090909 17.1 17 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00458682089454124 0.0178334593795961 2.15095336318358 0.409090909090909 17.1 17 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.02494345307503e-07 2.82293469670498e-06 2.14466402586433 0.407894736842105 17.1 17 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.50232881581874e-10 1.85056278098201e-08 2.14210170325278 0.407407407407407 17.1 17 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00183599274198765 0.00837377458925776 2.14210170325278 0.407407407407407 17.1 17 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.1515526194451e-08 8.05566964557184e-07 2.11524149380761 0.402298850574713 17.1 17 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 4.00974366399654e-05 0.000322365267450117 2.10315439955728 0.4 17.1 17 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 9.64100277364475e-05 0.000703545997276742 2.10315439955728 0.4 17.1 17 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00139083954557623 0.00705653605534379 2.10315439955728 0.4 17.1 17 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00345242272990963 0.0140767837955914 2.10315439955728 0.4 17.1 17 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.022558607074596 0.0676841993104193 2.10315439955728 0.4 17.1 17 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.022558607074596 0.0676841993104193 2.10315439955728 0.4 17.1 17 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.022558607074596 0.0676841993104193 2.10315439955728 0.4 17.1 17 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 5.2443348599734e-07 6.01829718205012e-06 2.10315439955728 0.4 17.1 17 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00871293953713843 0.0309189849410174 2.10315439955728 0.4 17.1 17 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000177445459809942 0.00125002420450271 2.0786991158415 0.395348837209302 17.1 17 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00648058294173097 0.0240152852241749 2.05743365174082 0.391304347826087 17.1 17 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000325808978193037 0.00215640081845903 2.05185795078759 0.390243902439024 17.1 17 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000325808978193037 0.00215640081845903 2.05185795078759 0.390243902439024 17.1 17 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.78713552449751e-05 0.00014959375596235 2.04968437244989 0.389830508474576 17.1 17 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.78713552449751e-05 0.00014959375596235 2.04968437244989 0.389830508474576 17.1 17 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.40061212258194e-07 2.05471242312794e-06 2.04473344401402 0.388888888888889 17.1 17 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000792212929361458 0.00447348808921173 2.04473344401402 0.388888888888889 17.1 17 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0165343340331235 0.0519389786515115 2.04473344401402 0.388888888888889 17.1 17 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0165343340331235 0.0519389786515115 2.04473344401402 0.388888888888889 17.1 17 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.03516863693386e-05 9.09287018738816e-05 2.02226384572815 0.384615384615385 17.1 17 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 7.75468272997555e-05 0.000571757177448456 2.02226384572815 0.384615384615385 17.1 17 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00481653025104772 0.018524114992543 2.02226384572815 0.384615384615385 17.1 17 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00481653025104772 0.018524114992543 2.02226384572815 0.384615384615385 17.1 17 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0435802142917466 0.108607083952987 2.02226384572815 0.384615384615385 17.1 17 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000448804753954816 0.00283844073278979 2.00300419005455 0.380952380952381 17.1 17 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0121345804375065 0.0408215318264106 2.00300419005455 0.380952380952381 17.1 17 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0121345804375065 0.0408215318264106 2.00300419005455 0.380952380952381 17.1 17 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0121345804375065 0.0408215318264106 2.00300419005455 0.380952380952381 17.1 17 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.44104335873411e-05 0.000349149430910422 1.99437055130431 0.379310344827586 17.1 17 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.44104335873411e-05 0.000349149430910422 1.99437055130431 0.379310344827586 17.1 17 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.94662865666938e-09 6.76298802974278e-08 1.99290840280629 0.379032258064516 17.1 17 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 8.10785503862054e-06 7.3022010885804e-05 1.97170724958495 0.375 17.1 17 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.00266096698667696 0.011405289223016 1.97170724958495 0.375 17.1 17 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00892079001553393 0.0313439115854439 1.97170724958495 0.375 17.1 17 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.00892079001553393 0.0313439115854439 1.97170724958495 0.375 17.1 17 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0313179849980764 0.0849470537676058 1.97170724958495 0.375 17.1 17 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0313179849980764 0.0849470537676058 1.97170724958495 0.375 17.1 17 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0313179849980764 0.0849470537676058 1.97170724958495 0.375 17.1 17 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0313179849980764 0.0849470537676058 1.97170724958495 0.375 17.1 17 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.06184380015243e-07 2.82293469670498e-06 1.96506850463685 0.373737373737374 17.1 17 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.06184380015243e-07 2.82293469670498e-06 1.96506850463685 0.373737373737374 17.1 17 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.03229518191034e-15 1.606642246588e-13 1.96324498671119 0.373390557939914 17.1 17 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.49389730598239e-06 1.5516904134401e-05 1.95642269726258 0.372093023255814 17.1 17 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000609610261596231 0.00354071592755688 1.95642269726258 0.372093023255814 17.1 17 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.31283065386373e-30 3.73631604089618e-28 1.95567710934442 0.371951219512195 17.1 17 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.25515812742749e-08 2.17815855527966e-07 1.95541214834871 0.371900826446281 17.1 17 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.25515812742749e-08 2.17815855527966e-07 1.95541214834871 0.371900826446281 17.1 17 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.25515812742749e-08 2.17815855527966e-07 1.95541214834871 0.371900826446281 17.1 17 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 7.75282902101252e-14 4.59678154037534e-12 1.95292908530319 0.371428571428571 17.1 17 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 4.53464184988603e-05 0.000354549195186144 1.9505060963636 0.370967741935484 17.1 17 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 2.77100874554482e-07 3.31356760076494e-06 1.94541781959048 0.37 17.1 17 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.27156666901297e-12 6.95938219232869e-11 1.94432242667405 0.369791666666667 17.1 17 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.65477483444163e-32 1.25924819647015e-29 1.93970700708232 0.368913857677903 17.1 17 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00147279775715889 0.00705653605534379 1.93711589432907 0.368421052631579 17.1 17 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00147279775715889 0.00705653605534379 1.93711589432907 0.368421052631579 17.1 17 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0226406738382007 0.0676841993104193 1.93711589432907 0.368421052631579 17.1 17 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0226406738382007 0.0676841993104193 1.93711589432907 0.368421052631579 17.1 17 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0226406738382007 0.0676841993104193 1.93711589432907 0.368421052631579 17.1 17 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000341459615765044 0.00224952330200767 1.93146832612403 0.36734693877551 17.1 17 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.00631325545913e-26 4.07854823216905e-24 1.92160407582868 0.365470852017937 17.1 17 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.1161304824347e-07 2.82293469670498e-06 1.91642573791434 0.364485981308411 17.1 17 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.20829802966239e-11 5.07427269715508e-10 1.91455631481437 0.364130434782609 17.1 17 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0164475858906294 0.0518955980540259 1.91195854505207 0.363636363636364 17.1 17 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0164475858906294 0.0518955980540259 1.91195854505207 0.363636363636364 17.1 17 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0164475858906294 0.0518955980540259 1.91195854505207 0.363636363636364 17.1 17 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 3.42524380342008e-05 0.000276938746151521 1.90503115901927 0.36231884057971 17.1 17 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00264993354095703 0.0113923124736612 1.89868105515588 0.361111111111111 17.1 17 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.0119967466136976 0.0407029041682036 1.89283895960155 0.36 17.1 17 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0119967466136976 0.0407029041682036 1.89283895960155 0.36 17.1 17 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0119967466136976 0.0407029041682036 1.89283895960155 0.36 17.1 17 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0119967466136976 0.0407029041682036 1.89283895960155 0.36 17.1 17 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.0415545670423e-09 2.74468916463184e-08 1.88744625601294 0.358974358974359 17.1 17 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.37735141538575e-54 1.95997106409392e-51 1.88420739499876 0.358358358358358 17.1 17 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 6.03433083712601e-05 0.000457835752464689 1.8834218503498 0.358208955223881 17.1 17 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 6.03433083712601e-05 0.000457835752464689 1.8834218503498 0.358208955223881 17.1 17 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000253389649191416 0.00173223458005503 1.87781642817614 0.357142857142857 17.1 17 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00877986324024578 0.0310018496051358 1.87781642817614 0.357142857142857 17.1 17 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00877986324024578 0.0310018496051358 1.87781642817614 0.357142857142857 17.1 17 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0591196294782515 0.141628337958842 1.87781642817614 0.357142857142857 17.1 17 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0591196294782515 0.141628337958842 1.87781642817614 0.357142857142857 17.1 17 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0591196294782515 0.141628337958842 1.87781642817614 0.357142857142857 17.1 17 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0591196294782515 0.141628337958842 1.87781642817614 0.357142857142857 17.1 17 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 6.53947462080999e-15 4.65283619270631e-13 1.87349960880102 0.35632183908046 17.1 17 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.03366235401308e-09 2.74468916463184e-08 1.8731218871057 0.35625 17.1 17 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.00108183837701678 0.00582911721724713 1.86947057738425 0.355555555555556 17.1 17 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.91020466735852e-05 0.00015803611870065 1.86355453125328 0.354430379746835 17.1 17 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00474108452381445 0.0183330523842064 1.8557244701976 0.352941176470588 17.1 17 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.0420242149110485 0.106786531818611 1.8557244701976 0.352941176470588 17.1 17 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0420242149110485 0.106786531818611 1.8557244701976 0.352941176470588 17.1 17 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0420242149110485 0.106786531818611 1.8557244701976 0.352941176470588 17.1 17 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0420242149110485 0.106786531818611 1.8557244701976 0.352941176470588 17.1 17 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0420242149110485 0.106786531818611 1.8557244701976 0.352941176470588 17.1 17 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 5.81617860520355e-10 1.7238848080302e-08 1.8557244701976 0.352941176470588 17.1 17 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.0762675805157e-05 9.33859004313315e-05 1.8557244701976 0.352941176470588 17.1 17 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.57369733715459e-06 2.61597950769356e-05 1.84026009961262 0.35 17.1 17 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0301402230772342 0.0842623525322284 1.84026009961262 0.35 17.1 17 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0301402230772342 0.0842623525322284 1.84026009961262 0.35 17.1 17 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0301402230772342 0.0842623525322284 1.84026009961262 0.35 17.1 17 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 5.44238528182076e-27 1.29075237600516e-24 1.83926050151397 0.349809885931559 17.1 17 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.30310387709374e-09 3.37148512200799e-08 1.83559333689171 0.349112426035503 17.1 17 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.00191042151847127 0.00868539878844924 1.83414627868367 0.348837209302326 17.1 17 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.39511355662186e-10 7.40923171972372e-09 1.82760743277036 0.347593582887701 17.1 17 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.44407700321214e-06 4.21594771704725e-05 1.82416453022825 0.346938775510204 17.1 17 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000579958379257278 0.00339621717565065 1.81636061779947 0.345454545454545 17.1 17 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000579958379257278 0.00339621717565065 1.81636061779947 0.345454545454545 17.1 17 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000579958379257278 0.00339621717565065 1.81636061779947 0.345454545454545 17.1 17 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 6.34651718426235e-08 9.81640647087535e-07 1.81567286292715 0.345323741007194 17.1 17 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00043162143574275 0.00277917331702232 1.81306413754938 0.344827586206897 17.1 17 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0115168918629603 0.0394904508939579 1.81306413754938 0.344827586206897 17.1 17 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.54965990300906e-15 4.15640317999047e-13 1.81244534432837 0.344709897610922 17.1 17 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 4.51254629159987e-07 5.22061249833058e-06 1.81009190125831 0.344262295081967 17.1 17 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.000239662019449933 0.00164753166027659 1.80739831211954 0.34375 17.1 17 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00842549898484313 0.0299737126385794 1.80739831211954 0.34375 17.1 17 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.23017922525995e-06 3.14831851886638e-05 1.80270377104909 0.342857142857143 17.1 17 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 9.7268144418913e-21 1.38412569508113e-18 1.80199848788358 0.342723004694836 17.1 17 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.97166109649715e-08 3.17398245439894e-07 1.79785779316993 0.341935483870968 17.1 17 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.97166109649715e-08 3.17398245439894e-07 1.79785779316993 0.341935483870968 17.1 17 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00335230165260209 0.0137870672013086 1.79537570693914 0.341463414634146 17.1 17 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00335230165260209 0.0137870672013086 1.79537570693914 0.341463414634146 17.1 17 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.00247589866830578 0.0107414750152412 1.79246113598632 0.340909090909091 17.1 17 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000747655835237046 0.00423870220534787 1.78392560676733 0.339285714285714 17.1 17 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.45653938181954e-09 7.56716236973725e-08 1.78233423691295 0.338983050847458 17.1 17 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000555866051139671 0.00331633445336563 1.78233423691295 0.338983050847458 17.1 17 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.82447532611028e-08 3.04724477422913e-07 1.77413331250997 0.337423312883436 17.1 17 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00173626335853888 0.00797000890064782 1.75262866629773 0.333333333333333 17.1 17 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000528025117308544 0.00321567470338837 1.75262866629773 0.333333333333333 17.1 17 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000709899289901529 0.0040407467581195 1.75262866629773 0.333333333333333 17.1 17 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0108476841667705 0.037285639056315 1.75262866629773 0.333333333333333 17.1 17 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0108476841667705 0.037285639056315 1.75262866629773 0.333333333333333 17.1 17 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0108476841667705 0.037285639056315 1.75262866629773 0.333333333333333 17.1 17 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0108476841667705 0.037285639056315 1.75262866629773 0.333333333333333 17.1 17 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.028184586187296 0.0800532258373696 1.75262866629773 0.333333333333333 17.1 17 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.028184586187296 0.0800532258373696 1.75262866629773 0.333333333333333 17.1 17 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.028184586187296 0.0800532258373696 1.75262866629773 0.333333333333333 17.1 17 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.028184586187296 0.0800532258373696 1.75262866629773 0.333333333333333 17.1 17 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.054769155350011 0.133583990715526 1.75262866629773 0.333333333333333 17.1 17 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.054769155350011 0.133583990715526 1.75262866629773 0.333333333333333 17.1 17 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.054769155350011 0.133583990715526 1.75262866629773 0.333333333333333 17.1 17 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.054769155350011 0.133583990715526 1.75262866629773 0.333333333333333 17.1 17 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0774001406800792 0.174826032044052 1.75262866629773 0.333333333333333 17.1 17 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0774001406800792 0.174826032044052 1.75262866629773 0.333333333333333 17.1 17 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0774001406800792 0.174826032044052 1.75262866629773 0.333333333333333 17.1 17 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0774001406800792 0.174826032044052 1.75262866629773 0.333333333333333 17.1 17 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0774001406800792 0.174826032044052 1.75262866629773 0.333333333333333 17.1 17 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0774001406800792 0.174826032044052 1.75262866629773 0.333333333333333 17.1 17 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0774001406800792 0.174826032044052 1.75262866629773 0.333333333333333 17.1 17 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0774001406800792 0.174826032044052 1.75262866629773 0.333333333333333 17.1 17 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00029289574174617 0.00195676357044507 1.75262866629773 0.333333333333333 17.1 17 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.020412162639168 0.0629660910577576 1.75262866629773 0.333333333333333 17.1 17 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.020412162639168 0.0629660910577576 1.75262866629773 0.333333333333333 17.1 17 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0391430443970979 0.102768546452159 1.75262866629773 0.333333333333333 17.1 17 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000206324465518705 0.00143219372894203 1.72956776279381 0.328947368421053 17.1 17 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.94401567713409e-16 4.67694525713484e-14 1.72919780177503 0.328877005347594 17.1 17 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000668853606960421 0.00382240434821156 1.72524384338683 0.328125 17.1 17 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000668853606960421 0.00382240434821156 1.72524384338683 0.328125 17.1 17 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.4233680220466e-08 2.44030445225579e-07 1.72389704881744 0.327868852459016 17.1 17 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000899362223769525 0.00499918923603139 1.72389704881744 0.327868852459016 17.1 17 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000899362223769525 0.00499918923603139 1.72389704881744 0.327868852459016 17.1 17 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00121053075544511 0.00637994542591998 1.72241093067191 0.327586206896552 17.1 17 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 5.93607558633028e-10 1.7238848080302e-08 1.72076269054686 0.327272727272727 17.1 17 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.07119893992435e-05 9.33859004313315e-05 1.72076269054686 0.327272727272727 17.1 17 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00163117902271068 0.00756080700103354 1.72076269054686 0.327272727272727 17.1 17 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00163117902271068 0.00756080700103354 1.72076269054686 0.327272727272727 17.1 17 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00163117902271068 0.00756080700103354 1.72076269054686 0.327272727272727 17.1 17 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.03547604777819e-12 2.86282747199612e-10 1.72041122757902 0.327205882352941 17.1 17 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.87316623196443e-11 7.61575870881537e-10 1.71892426886893 0.326923076923077 17.1 17 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00220072935720767 0.0096954732981626 1.71892426886893 0.326923076923077 17.1 17 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00220072935720767 0.0096954732981626 1.71892426886893 0.326923076923077 17.1 17 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00402329312771026 0.0159031836686992 1.71452804311735 0.326086956521739 17.1 17 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00740783382794794 0.0271503920911238 1.70881294964029 0.325 17.1 17 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0137682318220974 0.0450395261674588 1.7010807643478 0.323529411764706 17.1 17 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0137682318220974 0.0450395261674588 1.7010807643478 0.323529411764706 17.1 17 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 4.00043249932264e-06 3.84636178820008e-05 1.69742776342221 0.322834645669291 17.1 17 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.87965195037737e-07 3.41478727115583e-06 1.69716573381995 0.322784810126582 17.1 17 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0188558688569176 0.0587131321299645 1.69609225770748 0.32258064516129 17.1 17 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.0259221991965522 0.0752801825646811 1.69003478535853 0.321428571428571 17.1 17 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00276458883685439 0.0118138435881195 1.68649173549404 0.320754716981132 17.1 17 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00373386901434698 0.0150945897937948 1.68252351964582 0.32 17.1 17 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00058304435115781 0.00340029553974412 1.67960247186866 0.319444444444444 17.1 17 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0497342583667833 0.123081477662492 1.67296372692056 0.318181818181818 17.1 17 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 6.18580255012355e-06 5.64256219796527e-05 1.67111105391179 0.317829457364341 17.1 17 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.00141093448374111 0.00705653605534379 1.66917015837879 0.317460317460317 17.1 17 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.09521776884131e-05 9.44542354582537e-05 1.66713458501492 0.317073170731707 17.1 17 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.58385024468621e-05 0.000211311430930372 1.66038505228206 0.315789473684211 17.1 17 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00344341522168048 0.0140767837955914 1.65526040705897 0.314814814814815 17.1 17 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00344341522168048 0.0140767837955914 1.65526040705897 0.314814814814815 17.1 17 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.81011620983328e-31 1.35544884164819e-28 1.65349808562478 0.31447963800905 17.1 17 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 9.03042215123658e-07 9.73506872818913e-06 1.6534232700922 0.314465408805031 17.1 17 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.84162368646314e-08 3.04724477422913e-07 1.652478456795 0.314285714285714 17.1 17 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000970628297105105 0.00535350413480839 1.652478456795 0.314285714285714 17.1 17 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.0172451973792997 0.0538156049797006 1.652478456795 0.314285714285714 17.1 17 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 7.34938735067309e-09 1.34079207692408e-07 1.65045748844181 0.31390134529148 17.1 17 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0983465750809896 0.208565091416167 1.64308937465412 0.3125 17.1 17 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0983465750809896 0.208565091416167 1.64308937465412 0.3125 17.1 17 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0983465750809896 0.208565091416167 1.64308937465412 0.3125 17.1 17 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.47426738549231e-06 1.54256065408497e-05 1.64099626717049 0.312101910828025 17.1 17 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.00234918740072691 0.0102858266807212 1.63770219637657 0.311475409836066 17.1 17 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.000133447566285587 0.000953220751333847 1.62994465965689 0.31 17.1 17 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.00119694471201114 0.00635541912385018 1.6292041123331 0.309859154929577 17.1 17 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 9.45165819944244e-12 4.20303425556456e-10 1.62897695057734 0.309815950920245 17.1 17 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 9.22311429706629e-05 0.00067652018787244 1.62159100900444 0.308411214953271 17.1 17 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 6.75679797310182e-10 1.88527912073018e-08 1.61343072168203 0.306859205776173 17.1 17 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00288761276096183 0.0121570205883097 1.61128764482211 0.306451612903226 17.1 17 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.00773930853990186 0.0278528311632439 1.60955693843669 0.306122448979592 17.1 17 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00146706087078661 0.00705653605534379 1.60657627743959 0.305555555555556 17.1 17 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0213358670049891 0.064597742017233 1.60657627743959 0.305555555555556 17.1 17 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0213358670049891 0.064597742017233 1.60657627743959 0.305555555555556 17.1 17 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.0213358670049891 0.064597742017233 1.60657627743959 0.305555555555556 17.1 17 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.07783499648483e-07 1.59766583333116e-06 1.60240335204364 0.304761904761905 17.1 17 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.08802965960905e-24 1.93533275702959e-22 1.60227511874082 0.304737516005122 17.1 17 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0104601593780756 0.0363044068170771 1.60022617357619 0.304347826086957 17.1 17 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.061971543553691 0.145041951442273 1.60022617357619 0.304347826086957 17.1 17 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.00196381369287554 0.00881547913237189 1.60022617357619 0.304347826086957 17.1 17 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.00196381369287554 0.00881547913237189 1.60022617357619 0.304347826086957 17.1 17 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00100174835583473 0.00544946314392948 1.59733245535996 0.30379746835443 17.1 17 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.029140103421378 0.0824381057030238 1.59329878754339 0.303030303030303 17.1 17 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 7.60473455340763e-06 6.8926988977701e-05 1.59120234177031 0.302631578947368 17.1 17 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.00701852565099768 0.0259412000035577 1.58728633928851 0.30188679245283 17.1 17 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00352526928976169 0.0143327377123739 1.58571165045985 0.301587301587302 17.1 17 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.76238302583615e-05 0.000149278038438383 1.58104264302383 0.300699300699301 17.1 17 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.32147741190607e-06 1.3929350793647e-05 1.58023896141599 0.300546448087432 17.1 17 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00472796911236342 0.0183321527163301 1.57736579966796 0.3 17.1 17 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00945592547942538 0.0331423200916806 1.57736579966796 0.3 17.1 17 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.086508026221955 0.187083467042313 1.57736579966796 0.3 17.1 17 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.086508026221955 0.187083467042313 1.57736579966796 0.3 17.1 17 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.086508026221955 0.187083467042313 1.57736579966796 0.3 17.1 17 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.086508026221955 0.187083467042313 1.57736579966796 0.3 17.1 17 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.086508026221955 0.187083467042313 1.57736579966796 0.3 17.1 17 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.086508026221955 0.187083467042313 1.57736579966796 0.3 17.1 17 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.00216577840044439 0.00960094287798245 1.56315529696825 0.297297297297297 17.1 17 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.00216577840044439 0.00960094287798245 1.56315529696825 0.297297297297297 17.1 17 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0260956494848479 0.0756295503399971 1.56315529696825 0.297297297297297 17.1 17 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.0549168197952094 0.133583990715526 1.55789214782021 0.296296296296296 17.1 17 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0549168197952094 0.133583990715526 1.55789214782021 0.296296296296296 17.1 17 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0549168197952094 0.133583990715526 1.55789214782021 0.296296296296296 17.1 17 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0549168197952094 0.133583990715526 1.55789214782021 0.296296296296296 17.1 17 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.49495986038764e-05 0.00048687806290688 1.55346631785481 0.295454545454545 17.1 17 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.0172283357325032 0.0538156049797006 1.55346631785481 0.295454545454545 17.1 17 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.0172283357325032 0.0538156049797006 1.55346631785481 0.295454545454545 17.1 17 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0355450499210784 0.0943668023091317 1.546437058498 0.294117647058824 17.1 17 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0355450499210784 0.0943668023091317 1.546437058498 0.294117647058824 17.1 17 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.121814225151798 0.242811055523059 1.546437058498 0.294117647058824 17.1 17 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.121814225151798 0.242811055523059 1.546437058498 0.294117647058824 17.1 17 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.121814225151798 0.242811055523059 1.546437058498 0.294117647058824 17.1 17 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.121814225151798 0.242811055523059 1.546437058498 0.294117647058824 17.1 17 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00766674569092942 0.0276897947162248 1.54110451691697 0.293103448275862 17.1 17 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00766674569092942 0.0276897947162248 1.54110451691697 0.293103448275862 17.1 17 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00766674569092942 0.0276897947162248 1.54110451691697 0.293103448275862 17.1 17 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0758838201163244 0.173605588465482 1.53355008301051 0.291666666666667 17.1 17 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0758838201163244 0.173605588465482 1.53355008301051 0.291666666666667 17.1 17 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.62047548017166e-15 1.35643329899075e-13 1.52856230440678 0.290718038528897 17.1 17 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0485471715239053 0.12035300536327 1.52648303193673 0.290322580645161 17.1 17 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0485471715239053 0.12035300536327 1.52648303193673 0.290322580645161 17.1 17 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00108553482963492 0.00582911721724713 1.52648303193673 0.290322580645161 17.1 17 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.00312770675255815 0.0130903726732066 1.52201963125856 0.289473684210526 17.1 17 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00617269758249843 0.0233610336699342 1.51363384816622 0.287878787878788 17.1 17 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.93560868000389e-05 0.000238706922951174 1.50683318260963 0.286585365853659 17.1 17 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00252349594874402 0.010881620409281 1.50225314254091 0.285714285714286 17.1 17 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00252349594874402 0.010881620409281 1.50225314254091 0.285714285714286 17.1 17 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00552889400665148 0.0210928047492361 1.50225314254091 0.285714285714286 17.1 17 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0428649909377899 0.108607083952987 1.50225314254091 0.285714285714286 17.1 17 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0665146680346724 0.155164545267769 1.50225314254091 0.285714285714286 17.1 17 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00226374012088696 0.00994229071611773 1.49371761332193 0.284090909090909 17.1 17 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00202931938375364 0.00908088516692274 1.48592430403503 0.282608695652174 17.1 17 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0248367074000752 0.0734975834359369 1.48592430403503 0.282608695652174 17.1 17 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000269301329525009 0.00181618858727056 1.48505177067976 0.282442748091603 17.1 17 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000269301329525009 0.00181618858727056 1.48505177067976 0.282442748091603 17.1 17 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 6.57689433114751e-07 7.31165674470539e-06 1.48138851556118 0.281746031746032 17.1 17 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 6.57689433114751e-07 7.31165674470539e-06 1.48138851556118 0.281746031746032 17.1 17 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 6.57689433114751e-07 7.31165674470539e-06 1.48138851556118 0.281746031746032 17.1 17 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00395478898083839 0.015675946294521 1.47477290212858 0.280487804878049 17.1 17 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.00162805459187954 0.00756080700103354 1.47220807969009 0.28 17.1 17 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0914710417549936 0.19662128763951 1.47220807969009 0.28 17.1 17 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0914710417549936 0.19662128763951 1.47220807969009 0.28 17.1 17 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0914710417549936 0.19662128763951 1.47220807969009 0.28 17.1 17 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 8.34016849768532e-34 5.93402988610311e-31 1.46297538122851 0.278244028405423 17.1 17 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00775103383038973 0.0278528311632439 1.46052388858144 0.277777777777778 17.1 17 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.147600790460178 0.286542871520919 1.46052388858144 0.277777777777778 17.1 17 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.147600790460178 0.286542871520919 1.46052388858144 0.277777777777778 17.1 17 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.147600790460178 0.286542871520919 1.46052388858144 0.277777777777778 17.1 17 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.0194984718581409 0.0605814966247479 1.46052388858144 0.277777777777778 17.1 17 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.00116626473721868 0.00621571056577599 1.45530773183651 0.276785714285714 17.1 17 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.0294561413103539 0.0828381207206198 1.45430889331088 0.276595744680851 17.1 17 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.0294561413103539 0.0828381207206198 1.45430889331088 0.276595744680851 17.1 17 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00415314179203981 0.0162360460716281 1.4504513100395 0.275862068965517 17.1 17 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00415314179203981 0.0162360460716281 1.4504513100395 0.275862068965517 17.1 17 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 0.000456250812227883 0.00287276506991273 1.43740768315066 0.273381294964029 17.1 17 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0692491281481597 0.159969982718882 1.43396890878905 0.272727272727273 17.1 17 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0692491281481597 0.159969982718882 1.43396890878905 0.272727272727273 17.1 17 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.00178515951798702 0.0081681093057734 1.43396890878905 0.272727272727273 17.1 17 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.126348929171316 0.249714619737198 1.43396890878905 0.272727272727273 17.1 17 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00718370137970544 0.0264144885357128 1.42806780216852 0.271604938271605 17.1 17 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00718370137970544 0.0264144885357128 1.42806780216852 0.271604938271605 17.1 17 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 0.00053104958207749 0.00321567470338837 1.42714048541387 0.271428571428571 17.1 17 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 0.00053104958207749 0.00321567470338837 1.42714048541387 0.271428571428571 17.1 17 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.012013506500805 0.0407029041682036 1.42714048541387 0.271428571428571 17.1 17 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0346691186844771 0.0923860597153762 1.42401079136691 0.270833333333333 17.1 17 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00566789970029532 0.0215652975227814 1.41785689857794 0.269662921348315 17.1 17 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.108704976942396 0.222571485164072 1.41558469200971 0.269230769230769 17.1 17 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.108704976942396 0.222571485164072 1.41558469200971 0.269230769230769 17.1 17 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.108704976942396 0.222571485164072 1.41558469200971 0.269230769230769 17.1 17 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.0158375490532392 0.0503054292472306 1.41256638776235 0.26865671641791 17.1 17 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 0.00130904802181078 0.00682335287559247 1.40762302332574 0.267716535433071 17.1 17 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.000390898331442789 0.00252840148019586 1.40656822900327 0.267515923566879 17.1 17 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0939023911643545 0.200635289229544 1.40210293303818 0.266666666666667 17.1 17 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0939023911643545 0.200635289229544 1.40210293303818 0.266666666666667 17.1 17 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.00313958552667416 0.013101554851781 1.39888710062296 0.26605504587156 17.1 17 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.0405101483175127 0.106161954062285 1.39494934664513 0.26530612244898 17.1 17 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.175459042310764 0.323836857598206 1.38365421023505 0.263157894736842 17.1 17 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.175459042310764 0.323836857598206 1.38365421023505 0.263157894736842 17.1 17 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.175459042310764 0.323836857598206 1.38365421023505 0.263157894736842 17.1 17 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.00155146348134557 0.007383720849347 1.38365421023505 0.263157894736842 17.1 17 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00122775156484073 0.00644682832755854 1.37972895006417 0.26241134751773 17.1 17 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.0274556672996277 0.0787689809826012 1.37911763905395 0.262295081967213 17.1 17 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.0616061138218903 0.14442421741112 1.3770653806625 0.261904761904762 17.1 17 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.0241628094017498 0.0720831819259748 1.37513941509514 0.261538461538462 17.1 17 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00991533090136586 0.0346671151662005 1.37422020425618 0.261363636363636 17.1 17 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.149070359389301 0.28821619756926 1.37162243449388 0.260869565217391 17.1 17 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.149070359389301 0.28821619756926 1.37162243449388 0.260869565217391 17.1 17 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0411635857037954 0.106786531818611 1.36315562934268 0.259259259259259 17.1 17 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.127530831943912 0.251352318360369 1.36315562934268 0.259259259259259 17.1 17 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.127530831943912 0.251352318360369 1.36315562934268 0.259259259259259 17.1 17 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.0128967488482478 0.0424851042206873 1.36086461147824 0.258823529411765 17.1 17 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.0128967488482478 0.0424851042206873 1.36086461147824 0.258823529411765 17.1 17 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.0128967488482478 0.0424851042206873 1.36086461147824 0.258823529411765 17.1 17 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.0128967488482478 0.0424851042206873 1.36086461147824 0.258823529411765 17.1 17 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.0128967488482478 0.0424851042206873 1.36086461147824 0.258823529411765 17.1 17 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00100717414395886 0.00544946314392948 1.3558070814756 0.257861635220126 17.1 17 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00100717414395886 0.00544946314392948 1.3558070814756 0.257861635220126 17.1 17 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0947156135541041 0.201766943244746 1.35202782828682 0.257142857142857 17.1 17 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0947156135541041 0.201766943244746 1.35202782828682 0.257142857142857 17.1 17 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0820691098099701 0.183912351589902 1.3481758971521 0.256410256410256 17.1 17 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 0.00114832953831645 0.00614313132715907 1.34733328721638 0.25625 17.1 17 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0713091489112938 0.16366599822705 1.34504060436803 0.255813953488372 17.1 17 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0473804391646205 0.117871267362334 1.33837098153645 0.254545454545455 17.1 17 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.00628769095200716 0.0236920034286636 1.32551747871257 0.252100840336134 17.1 17 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 9.39257173092489e-10 2.57031337944349e-08 1.32469289552208 0.25194401244168 17.1 17 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.0008317167094239 0.00465957825791421 1.3144714997233 0.25 17.1 17 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.0319867732333784 0.0853980831352674 1.3144714997233 0.25 17.1 17 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0319867732333784 0.0853980831352674 1.3144714997233 0.25 17.1 17 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0712508749885475 0.16366599822705 1.3144714997233 0.25 17.1 17 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0712508749885475 0.16366599822705 1.3144714997233 0.25 17.1 17 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.0712508749885475 0.16366599822705 1.3144714997233 0.25 17.1 17 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.173465872480293 0.321572453159301 1.3144714997233 0.25 17.1 17 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.0364299330171815 0.0961777266854347 1.3144714997233 0.25 17.1 17 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0819336517991263 0.183898401435579 1.3144714997233 0.25 17.1 17 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.147869553246991 0.286673534428432 1.3144714997233 0.25 17.1 17 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.205109381007033 0.36842263925001 1.3144714997233 0.25 17.1 17 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.205109381007033 0.36842263925001 1.3144714997233 0.25 17.1 17 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.0246935013035804 0.0733587731837055 1.29900712913832 0.247058823529412 17.1 17 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.0246935013035804 0.0733587731837055 1.29900712913832 0.247058823529412 17.1 17 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0363158818092074 0.096054832368963 1.29646504082298 0.246575342465753 17.1 17 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0812208403953696 0.18258650218422 1.28764555074935 0.244897959183673 17.1 17 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0812208403953696 0.18258650218422 1.28764555074935 0.244897959183673 17.1 17 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0934874943207683 0.200350458461526 1.28526102195167 0.244444444444444 17.1 17 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.0278965622708401 0.0798728533428682 1.28390239507857 0.244186046511628 17.1 17 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.0317027803772133 0.0849586750975037 1.28241121924224 0.24390243902439 17.1 17 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.10789745824715 0.221875842609386 1.28241121924224 0.24390243902439 17.1 17 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.10789745824715 0.221875842609386 1.28241121924224 0.24390243902439 17.1 17 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.10789745824715 0.221875842609386 1.28241121924224 0.24390243902439 17.1 17 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.10789745824715 0.221875842609386 1.28241121924224 0.24390243902439 17.1 17 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00149311389953579 0.00712986939274978 1.28110927891814 0.243654822335025 17.1 17 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0360607465492064 0.0955576207439865 1.2807671022945 0.243589743589744 17.1 17 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.145217236308117 0.283462451668655 1.27463903003471 0.242424242424242 17.1 17 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0610366635024672 0.143442529102206 1.27206919328061 0.241935483870968 17.1 17 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.0406017416055512 0.106206393942462 1.2645548604933 0.240506329113924 17.1 17 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0920240617806944 0.197511674078323 1.26189263973437 0.24 17.1 17 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.199358976919862 0.360009929133202 1.26189263973437 0.24 17.1 17 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.105970309569733 0.219498909050553 1.25732056495272 0.239130434782609 17.1 17 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.105970309569733 0.219498909050553 1.25732056495272 0.239130434782609 17.1 17 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.105970309569733 0.219498909050553 1.25732056495272 0.239130434782609 17.1 17 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.0210256470155251 0.0640674426190412 1.25417464193783 0.238532110091743 17.1 17 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.122363503380044 0.242811055523059 1.25187761878409 0.238095238095238 17.1 17 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.236251681649263 0.415557655113598 1.25187761878409 0.238095238095238 17.1 17 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.236251681649263 0.415557655113598 1.25187761878409 0.238095238095238 17.1 17 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.236251681649263 0.415557655113598 1.25187761878409 0.238095238095238 17.1 17 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0786884797535919 0.177454368762855 1.24763396583906 0.23728813559322 17.1 17 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.141751927068413 0.27707828601422 1.24528878921155 0.236842105263158 17.1 17 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.141751927068413 0.27707828601422 1.24528878921155 0.236842105263158 17.1 17 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0075465574703877 0.0274648370341731 1.24099172644684 0.236024844720497 17.1 17 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0123620067283058 0.0414885272980641 1.23935884259625 0.235714285714286 17.1 17 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.164858663999872 0.309490605371792 1.2371496467984 0.235294117647059 17.1 17 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00837333236371565 0.029862786851046 1.233331283691 0.234567901234568 17.1 17 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.0509033157217746 0.125537986606734 1.233331283691 0.234567901234568 17.1 17 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0386859616243368 0.101756235473995 1.23056906357075 0.234042553191489 17.1 17 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0062934485565951 0.0236920034286636 1.22210323217517 0.232432432432432 17.1 17 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0152046480340579 0.0489507107521818 1.22190308424983 0.232394366197183 17.1 17 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.159656772245947 0.303595573487207 1.21335830743689 0.230769230769231 17.1 17 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.159656772245947 0.303595573487207 1.21335830743689 0.230769230769231 17.1 17 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.226555176913101 0.401980070757286 1.21335830743689 0.230769230769231 17.1 17 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.226555176913101 0.401980070757286 1.21335830743689 0.230769230769231 17.1 17 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.133680181480508 0.263107743079893 1.20493220807969 0.229166666666667 17.1 17 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0629289157622657 0.147040799884572 1.20361245757796 0.228915662650602 17.1 17 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0029146001996205 0.0122344427258406 1.19591132523845 0.227450980392157 17.1 17 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0259122241273222 0.0752801825646811 1.18974062748678 0.226277372262774 17.1 17 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0259122241273222 0.0752801825646811 1.18974062748678 0.226277372262774 17.1 17 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.216869931399175 0.38672420097873 1.18726458039524 0.225806451612903 17.1 17 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.178584532281414 0.329178483725974 1.18302434975097 0.225 17.1 17 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0498861324935151 0.123242997462278 1.17933891563959 0.224299065420561 17.1 17 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0871743780523842 0.188238452152569 1.16841911086515 0.222222222222222 17.1 17 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.171644082348798 0.321572453159301 1.16841911086515 0.222222222222222 17.1 17 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.207471155693769 0.370893787125921 1.16841911086515 0.222222222222222 17.1 17 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.254847846904299 0.430188002544267 1.16841911086515 0.222222222222222 17.1 17 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.254847846904299 0.430188002544267 1.16841911086515 0.222222222222222 17.1 17 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0248435260946491 0.0734975834359369 1.16125089546107 0.220858895705521 17.1 17 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0383464481931456 0.101049992183048 1.1598277938735 0.220588235294118 17.1 17 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.198465271853551 0.358851438179927 1.15417009731802 0.219512195121951 17.1 17 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.198465271853551 0.358851438179927 1.15417009731802 0.219512195121951 17.1 17 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0312601647198506 0.0849470537676058 1.15334273524109 0.219354838709677 17.1 17 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.242089309124014 0.420978769937647 1.15016256225789 0.21875 17.1 17 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.301772037620049 0.49020731681887 1.14301869541156 0.217391304347826 17.1 17 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.230241175712402 0.406492795333434 1.13684021597691 0.216216216216216 17.1 17 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.230241175712402 0.406492795333434 1.13684021597691 0.216216216216216 17.1 17 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.230241175712402 0.406492795333434 1.13684021597691 0.216216216216216 17.1 17 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.219220299619052 0.389938107947389 1.12668985690568 0.214285714285714 17.1 17 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.284023745174473 0.474930422307022 1.12668985690568 0.214285714285714 17.1 17 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0419997375373966 0.106786531818611 1.12210981683696 0.213414634146341 17.1 17 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00120669989208026 0.00637994542591998 1.11530915128037 0.212121212121212 17.1 17 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.268170251805218 0.451605051264882 1.11530915128037 0.212121212121212 17.1 17 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.268170251805218 0.451605051264882 1.11530915128037 0.212121212121212 17.1 17 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.153102790787883 0.295610951548382 1.11082098568166 0.211267605633803 17.1 17 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.146826720496783 0.28621153872181 1.10692336818804 0.210526315789474 17.1 17 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.102479228986704 0.213198746853918 1.09937616340494 0.209090909090909 17.1 17 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.228750841756367 0.405370420696526 1.09539291643608 0.208333333333333 17.1 17 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.217650826390189 0.387630946124205 1.09125935826085 0.207547169811321 17.1 17 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.313868032613442 0.500710998216288 1.08783848252963 0.206896551724138 17.1 17 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.29495473753253 0.482437461504357 1.0825059409486 0.205882352941176 17.1 17 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.278143221313341 0.467846103934852 1.07854071772168 0.205128205128205 17.1 17 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.186036123359154 0.33723490896825 1.0648883035733 0.20253164556962 17.1 17 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.344168708575473 0.542992429413215 1.05157719977864 0.2 17.1 17 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.344168708575473 0.542992429413215 1.05157719977864 0.2 17.1 17 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.369581278170015 0.572538096227524 1.05157719977864 0.2 17.1 17 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.369581278170015 0.572538096227524 1.05157719977864 0.2 17.1 17 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.369581278170015 0.572538096227524 1.05157719977864 0.2 17.1 17 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.322282974401193 0.51184003635368 1.05157719977864 0.2 17.1 17 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.106838805284746 0.220976191744468 1.03934955792075 0.197674418604651 17.1 17 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.160393213858394 0.304319391093992 1.03433822929046 0.19672131147541 17.1 17 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.291923211166484 0.481535968044525 1.03095803899867 0.196078431372549 17.1 17 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.309183787079368 0.496512836443859 1.02871682587041 0.195652173913043 17.1 17 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.374720415097785 0.573362527617363 1.01765535462449 0.193548387096774 17.1 17 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.403635111802614 0.594444472242304 1.01113192286408 0.192307692307692 17.1 17 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.354067871914078 0.55550009011437 1.00150209502727 0.19047619047619 17.1 17 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.000130034293201601 0.00093453939002969 0.99515110613198 0.189268292682927 17.1 17 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.377939004492051 0.577666169057131 0.994735188979793 0.189189189189189 17.1 17 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.124509881636362 0.246422199678085 0.989719717438719 0.188235294117647 17.1 17 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.35696479862109 0.5594283132575 0.985853624792474 0.1875 17.1 17 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.405327593399425 0.594444472242304 0.985853624792474 0.1875 17.1 17 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.381204185365227 0.582031712204634 0.965734163062015 0.183673469387755 17.1 17 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.435807002642581 0.626417540162014 0.955979272526035 0.181818181818182 17.1 17 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.289644591014993 0.481535968044525 0.952215574602704 0.181102362204724 17.1 17 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.382192461740035 0.582915190842518 0.948143376849592 0.180327868852459 17.1 17 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.433922043711147 0.624697518632313 0.943723128006471 0.179487179487179 17.1 17 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.345714083660136 0.542992429413215 0.940884862959835 0.178947368421053 17.1 17 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.470804019737119 0.67197003017645 0.93890821408807 0.178571428571429 17.1 17 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.470804019737119 0.67197003017645 0.93890821408807 0.178571428571429 17.1 17 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.461686408892321 0.660281165682184 0.920130049806309 0.175 17.1 17 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.503499017054552 0.678483997413473 0.906532068774689 0.172413793103448 17.1 17 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.478249397066062 0.676656343124947 0.892848565849788 0.169811320754717 17.1 17 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.535365078750368 0.714657136080463 0.876314333148866 0.166666666666667 17.1 17 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.535365078750368 0.714657136080463 0.876314333148866 0.166666666666667 17.1 17 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.535365078750368 0.714657136080463 0.876314333148866 0.166666666666667 17.1 17 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.518580260627924 0.697485549029806 0.86194852440872 0.163934426229508 17.1 17 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.500567167065319 0.676656343124947 0.859462134434464 0.163461538461538 17.1 17 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.522628145287398 0.7022661480113 0.849759353356476 0.161616161616162 17.1 17 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.566258283298941 0.744311371988287 0.848046128853741 0.161290322580645 17.1 17 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.566258283298941 0.744311371988287 0.848046128853741 0.161290322580645 17.1 17 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.566258283298941 0.744311371988287 0.848046128853741 0.161290322580645 17.1 17 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.566258283298941 0.744311371988287 0.848046128853741 0.161290322580645 17.1 17 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.578693417093335 0.744311371988287 0.82381623945792 0.15668202764977 17.1 17 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.581312693214326 0.744311371988287 0.823524313079657 0.156626506024096 17.1 17 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.596060262909963 0.758670620859461 0.821544687327062 0.15625 17.1 17 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.614094511277036 0.778838225977916 0.804147270418959 0.152941176470588 17.1 17 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.614094511277036 0.778838225977916 0.804147270418959 0.152941176470588 17.1 17 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.652036793365119 0.808230276096311 0.773218529248999 0.147058823529412 17.1 17 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.670283834800039 0.83012523665836 0.764783418020828 0.145454545454545 17.1 17 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.681828420712861 0.837137051487835 0.762012463607709 0.144927536231884 17.1 17 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.67808925183167 0.835429441867071 0.751126571270456 0.142857142857143 17.1 17 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.67808925183167 0.835429441867071 0.751126571270456 0.142857142857143 17.1 17 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.803471480585069 0.944909022208722 0.751126571270456 0.142857142857143 17.1 17 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.799848425993231 0.941426228443646 0.734973311673242 0.139784946236559 17.1 17 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.702802483308563 0.857510610676082 0.730261944290721 0.138888888888889 17.1 17 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.930975434845819 1 0.704665133872284 0.134020618556701 17.1 17 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.917738358909698 1 0.657235749861649 0.125 17.1 17 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.8686385685233 1 0.650460123574416 0.123711340206186 17.1 17 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.895122601843216 1 0.584209555432577 0.111111111111111 17.1 17 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999965759532 1 0.560664585944111 0.106633081444165 17.1 17 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.910597939534498 1 0.55346168409402 0.105263157894737 17.1 17 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.984760996364565 1 0.486841296193814 0.0925925925925926 17.1 17 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999999994862 1 0.480150529736178 0.0913200723327306 17.1 17 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.982586503505989 1 0.467367644346062 0.0888888888888889 17.1 17 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 7.55580640245793e-06 3.52521721662218e-05 1.92070598364184 1 17.2 17 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.000188542208587372 0.000665745813448711 1.92070598364184 1 17.2 17 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000188542208587372 0.000665745813448711 1.92070598364184 1 17.2 17 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.000550894735411604 0.00167863642075099 1.92070598364184 1 17.2 17 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000550894735411604 0.00167863642075099 1.92070598364184 1 17.2 17 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.000550894735411604 0.00167863642075099 1.92070598364184 1 17.2 17 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 8.84584287019689e-07 4.62780676628315e-06 1.92070598364184 1 17.2 17 2 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00470234909039873 0.0112436600271701 1.92070598364184 1 17.2 17 2 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00470234909039873 0.0112436600271701 1.92070598364184 1 17.2 17 2 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00470234909039873 0.0112436600271701 1.92070598364184 1 17.2 17 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00470234909039873 0.0112436600271701 1.92070598364184 1 17.2 17 2 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00470234909039873 0.0112436600271701 1.92070598364184 1 17.2 17 2 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.00470234909039873 0.0112436600271701 1.92070598364184 1 17.2 17 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00470234909039873 0.0112436600271701 1.92070598364184 1 17.2 17 2 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.00470234909039873 0.0112436600271701 1.92070598364184 1 17.2 17 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 2.58536777914433e-06 1.2686132240422e-05 1.92070598364184 1 17.2 17 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 2.58536777914433e-06 1.2686132240422e-05 1.92070598364184 1 17.2 17 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00160954842240424 0.00441307785179427 1.92070598364184 1 17.2 17 2 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.00160954842240424 0.00441307785179427 1.92070598364184 1 17.2 17 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 4.0827453512667e-07 2.20902913872719e-06 1.80772327872173 0.941176470588235 17.2 17 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 8.4498133032265e-06 3.90085008353352e-05 1.783512699096 0.928571428571429 17.2 17 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 2.63019491854972e-09 1.96987756268224e-08 1.7670495049505 0.92 17.2 17 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 6.22306312589074e-05 0.000241951334102255 1.76064715167169 0.916666666666667 17.2 17 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 6.22306312589074e-05 0.000241951334102255 1.76064715167169 0.916666666666667 17.2 17 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 6.22306312589074e-05 0.000241951334102255 1.76064715167169 0.916666666666667 17.2 17 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 6.22306312589074e-05 0.000241951334102255 1.76064715167169 0.916666666666667 17.2 17 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000167330673731779 0.000595278871800803 1.74609634876531 0.909090909090909 17.2 17 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000167330673731779 0.000595278871800803 1.74609634876531 0.909090909090909 17.2 17 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000167330673731779 0.000595278871800803 1.74609634876531 0.909090909090909 17.2 17 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 3.60024008794598e-07 1.9857138159485e-06 1.72863538527766 0.9 17.2 17 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000446516811026163 0.0013995449825776 1.72863538527766 0.9 17.2 17 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.000446516811026163 0.0013995449825776 1.72863538527766 0.9 17.2 17 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000446516811026163 0.0013995449825776 1.72863538527766 0.9 17.2 17 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00118068470920671 0.00328751270103678 1.70729420768164 0.888888888888889 17.2 17 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 1.68437988645467e-05 7.2853269860942e-05 1.68061773568661 0.875 17.2 17 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 1.68437988645467e-05 7.2853269860942e-05 1.68061773568661 0.875 17.2 17 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 1.68437988645467e-05 7.2853269860942e-05 1.68061773568661 0.875 17.2 17 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 1.68437988645467e-05 7.2853269860942e-05 1.68061773568661 0.875 17.2 17 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 1.68437988645467e-05 7.2853269860942e-05 1.68061773568661 0.875 17.2 17 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00308736242318123 0.00769407483044988 1.68061773568661 0.875 17.2 17 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00308736242318123 0.00769407483044988 1.68061773568661 0.875 17.2 17 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00308736242318123 0.00769407483044988 1.68061773568661 0.875 17.2 17 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00308736242318123 0.00769407483044988 1.68061773568661 0.875 17.2 17 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00308736242318123 0.00769407483044988 1.68061773568661 0.875 17.2 17 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00308736242318123 0.00769407483044988 1.68061773568661 0.875 17.2 17 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00308736242318123 0.00769407483044988 1.68061773568661 0.875 17.2 17 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.02699347454303e-07 6.11469336516626e-07 1.68061773568661 0.875 17.2 17 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 1.02699347454303e-07 6.11469336516626e-07 1.68061773568661 0.875 17.2 17 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 6.72776729978132e-07 3.57224360730926e-06 1.65879153132705 0.863636363636364 17.2 17 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.70572865888581e-06 8.60727617586702e-06 1.64631941455015 0.857142857142857 17.2 17 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.70572865888581e-06 8.60727617586702e-06 1.64631941455015 0.857142857142857 17.2 17 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000110264507973121 0.000409677271137732 1.64631941455015 0.857142857142857 17.2 17 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000110264507973121 0.000409677271137732 1.64631941455015 0.857142857142857 17.2 17 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000110264507973121 0.000409677271137732 1.64631941455015 0.857142857142857 17.2 17 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.000110264507973121 0.000409677271137732 1.64631941455015 0.857142857142857 17.2 17 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00796147054436003 0.0177018321634755 1.64631941455015 0.857142857142857 17.2 17 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00796147054436003 0.0177018321634755 1.64631941455015 0.857142857142857 17.2 17 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00796147054436003 0.0177018321634755 1.64631941455015 0.857142857142857 17.2 17 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00796147054436003 0.0177018321634755 1.64631941455015 0.857142857142857 17.2 17 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00796147054436003 0.0177018321634755 1.64631941455015 0.857142857142857 17.2 17 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00796147054436003 0.0177018321634755 1.64631941455015 0.857142857142857 17.2 17 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00796147054436003 0.0177018321634755 1.64631941455015 0.857142857142857 17.2 17 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00796147054436003 0.0177018321634755 1.64631941455015 0.857142857142857 17.2 17 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.74266810848665e-07 9.95910328665261e-07 1.62521275538925 0.846153846153846 17.2 17 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000278027869917377 0.000905340180531872 1.62521275538925 0.846153846153846 17.2 17 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000278027869917377 0.000905340180531872 1.62521275538925 0.846153846153846 17.2 17 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000278027869917377 0.000905340180531872 1.62521275538925 0.846153846153846 17.2 17 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000278027869917377 0.000905340180531872 1.62521275538925 0.846153846153846 17.2 17 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000278027869917377 0.000905340180531872 1.62521275538925 0.846153846153846 17.2 17 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 1.07242673039885e-05 4.84464519796052e-05 1.61743661780366 0.842105263157895 17.2 17 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 4.32981701712307e-07 2.33383697551747e-06 1.61339302625915 0.84 17.2 17 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 4.95012581437593e-18 2.13455425268392e-16 1.60497349318017 0.835616438356164 17.2 17 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.85893171400457e-09 1.42987017785325e-08 1.60058831970154 0.833333333333333 17.2 17 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 2.65516755456697e-05 0.000112449506849666 1.60058831970154 0.833333333333333 17.2 17 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000692830886096137 0.00202859742986585 1.60058831970154 0.833333333333333 17.2 17 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000692830886096137 0.00202859742986585 1.60058831970154 0.833333333333333 17.2 17 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.000692830886096137 0.00202859742986585 1.60058831970154 0.833333333333333 17.2 17 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0201663524303712 0.0398565548728031 1.60058831970154 0.833333333333333 17.2 17 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 6.51003713364379e-05 0.000249697650705529 1.58175786888152 0.823529411764706 17.2 17 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 6.51003713364379e-05 0.000249697650705529 1.58175786888152 0.823529411764706 17.2 17 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 6.51003713364379e-05 0.000249697650705529 1.58175786888152 0.823529411764706 17.2 17 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.12319892122745e-12 3.92378190247619e-11 1.58175786888152 0.823529411764706 17.2 17 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.12319892122745e-12 3.92378190247619e-11 1.58175786888152 0.823529411764706 17.2 17 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 2.6753261299814e-08 1.77896686119791e-07 1.57148671388878 0.818181818181818 17.2 17 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0017028544288509 0.00461554638524729 1.57148671388878 0.818181818181818 17.2 17 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0017028544288509 0.00461554638524729 1.57148671388878 0.818181818181818 17.2 17 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0017028544288509 0.00461554638524729 1.57148671388878 0.818181818181818 17.2 17 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0017028544288509 0.00461554638524729 1.57148671388878 0.818181818181818 17.2 17 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0017028544288509 0.00461554638524729 1.57148671388878 0.818181818181818 17.2 17 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0017028544288509 0.00461554638524729 1.57148671388878 0.818181818181818 17.2 17 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.67241506599354e-23 1.03471592996035e-21 1.56169551940972 0.813084112149533 17.2 17 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 6.42971755260115e-08 4.0129333672594e-07 1.560573611709 0.8125 17.2 17 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000157878435942368 0.000565896761576799 1.560573611709 0.8125 17.2 17 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000157878435942368 0.000565896761576799 1.560573611709 0.8125 17.2 17 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 7.06034515580225e-11 7.84911809117703e-10 1.55291122081681 0.808510638297872 17.2 17 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.13171309604548e-21 1.21337109426909e-19 1.55208564334694 0.808080808080808 17.2 17 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.51958424333962e-06 7.74147276044562e-06 1.5513394483261 0.807692307692308 17.2 17 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 1.51958424333962e-06 7.74147276044562e-06 1.5513394483261 0.807692307692308 17.2 17 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.51958424333962e-06 7.74147276044562e-06 1.5513394483261 0.807692307692308 17.2 17 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.56849099165112e-08 1.07305898130747e-07 1.54723537571148 0.805555555555556 17.2 17 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.61624416360127e-09 1.2636898048377e-08 1.54593408439465 0.804878048780488 17.2 17 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.61624416360127e-09 1.2636898048377e-08 1.54593408439465 0.804878048780488 17.2 17 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.63850372067047e-07 1.99138107481311e-06 1.53656478691347 0.8 17.2 17 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 3.63850372067047e-07 1.99138107481311e-06 1.53656478691347 0.8 17.2 17 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 3.60975958516413e-06 1.73536753030019e-05 1.53656478691347 0.8 17.2 17 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 3.6445848018238e-05 0.000148602984899578 1.53656478691347 0.8 17.2 17 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 3.6445848018238e-05 0.000148602984899578 1.53656478691347 0.8 17.2 17 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 3.6445848018238e-05 0.000148602984899578 1.53656478691347 0.8 17.2 17 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 3.6445848018238e-05 0.000148602984899578 1.53656478691347 0.8 17.2 17 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 3.6445848018238e-05 0.000148602984899578 1.53656478691347 0.8 17.2 17 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 3.6445848018238e-05 0.000148602984899578 1.53656478691347 0.8 17.2 17 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000378171366599054 0.00120658711809519 1.53656478691347 0.8 17.2 17 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000378171366599054 0.00120658711809519 1.53656478691347 0.8 17.2 17 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000378171366599054 0.00120658711809519 1.53656478691347 0.8 17.2 17 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000378171366599054 0.00120658711809519 1.53656478691347 0.8 17.2 17 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000378171366599054 0.00120658711809519 1.53656478691347 0.8 17.2 17 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00411735630192889 0.0100670069031698 1.53656478691347 0.8 17.2 17 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.00411735630192889 0.0100670069031698 1.53656478691347 0.8 17.2 17 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00411735630192889 0.0100670069031698 1.53656478691347 0.8 17.2 17 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00411735630192889 0.0100670069031698 1.53656478691347 0.8 17.2 17 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.55888254419247e-07 4.4942029005114e-06 1.52331853875043 0.793103448275862 17.2 17 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.36825244762814e-11 2.73985628697142e-10 1.52206889269731 0.792452830188679 17.2 17 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 8.49798682990436e-06 3.90085008353352e-05 1.52055890371646 0.791666666666667 17.2 17 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 8.49798682990436e-06 3.90085008353352e-05 1.52055890371646 0.791666666666667 17.2 17 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.64552858196687e-18 2.06580849129339e-16 1.51522360931745 0.788888888888889 17.2 17 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.29878529432839e-20 6.60061240653324e-19 1.51440279479453 0.788461538461538 17.2 17 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.99684237510903e-06 1.0005305280916e-05 1.5091261300043 0.785714285714286 17.2 17 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000893160197046318 0.00257802628883755 1.5091261300043 0.785714285714286 17.2 17 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000893160197046318 0.00257802628883755 1.5091261300043 0.785714285714286 17.2 17 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.000893160197046318 0.00257802628883755 1.5091261300043 0.785714285714286 17.2 17 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.000893160197046318 0.00257802628883755 1.5091261300043 0.785714285714286 17.2 17 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4.86687906792322e-08 3.09177183645301e-07 1.50541820339496 0.783783783783784 17.2 17 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.26829542894925e-12 4.83594732505317e-11 1.50455302051944 0.783333333333333 17.2 17 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.26829542894925e-12 4.83594732505317e-11 1.50455302051944 0.783333333333333 17.2 17 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.26829542894925e-12 4.83594732505317e-11 1.50455302051944 0.783333333333333 17.2 17 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.26829542894925e-12 4.83594732505317e-11 1.50455302051944 0.783333333333333 17.2 17 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.26829542894925e-12 4.83594732505317e-11 1.50455302051944 0.783333333333333 17.2 17 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.26829542894925e-12 4.83594732505317e-11 1.50455302051944 0.783333333333333 17.2 17 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.26829542894925e-12 4.83594732505317e-11 1.50455302051944 0.783333333333333 17.2 17 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.49639588669997e-31 1.77447612231172e-29 1.50019638959008 0.781065088757396 17.2 17 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 2.94099145942366e-10 2.59939804146575e-09 1.49815066724064 0.78 17.2 17 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.2134297681271e-30 3.04847370669657e-28 1.49650098111972 0.779141104294479 17.2 17 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.61772749810313e-06 2.17583649993402e-05 1.49388243172143 0.777777777777778 17.2 17 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000200020806604126 0.000701058147284904 1.49388243172143 0.777777777777778 17.2 17 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000200020806604126 0.000701058147284904 1.49388243172143 0.777777777777778 17.2 17 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000200020806604126 0.000701058147284904 1.49388243172143 0.777777777777778 17.2 17 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00976073442209202 0.02117305652841 1.49388243172143 0.777777777777778 17.2 17 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.80029096784312e-09 2.0862900770894e-08 1.49388243172143 0.777777777777778 17.2 17 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.43699216022319e-31 4.85679987999816e-29 1.49137170494543 0.776470588235294 17.2 17 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 4.56876782236798e-05 0.000183654141560159 1.48418189645051 0.772727272727273 17.2 17 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 4.56876782236798e-05 0.000183654141560159 1.48418189645051 0.772727272727273 17.2 17 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 4.56876782236798e-05 0.000183654141560159 1.48418189645051 0.772727272727273 17.2 17 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 4.56876782236798e-05 0.000183654141560159 1.48418189645051 0.772727272727273 17.2 17 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.55972194212566e-15 5.41337639913371e-14 1.48102630063949 0.771084337349398 17.2 17 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.002075507606692 0.00546934689689392 1.47746614126296 0.769230769230769 17.2 17 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.002075507606692 0.00546934689689392 1.47746614126296 0.769230769230769 17.2 17 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.002075507606692 0.00546934689689392 1.47746614126296 0.769230769230769 17.2 17 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 3.47985449340326e-09 2.5790796583921e-08 1.47117905130013 0.765957446808511 17.2 17 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 5.82274198290521e-07 3.11494806077974e-06 1.46877516396141 0.764705882352941 17.2 17 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.000459407145911642 0.0014211660187658 1.46877516396141 0.764705882352941 17.2 17 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.000459407145911642 0.0014211660187658 1.46877516396141 0.764705882352941 17.2 17 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000459407145911642 0.0014211660187658 1.46877516396141 0.764705882352941 17.2 17 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000459407145911642 0.0014211660187658 1.46877516396141 0.764705882352941 17.2 17 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000459407145911642 0.0014211660187658 1.46877516396141 0.764705882352941 17.2 17 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000459407145911642 0.0014211660187658 1.46877516396141 0.764705882352941 17.2 17 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 1.37907274204247e-07 7.94502231549165e-07 1.46580193488456 0.763157894736842 17.2 17 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 1.37907274204247e-07 7.94502231549165e-07 1.46580193488456 0.763157894736842 17.2 17 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.58930704823569e-27 1.41348995602462e-25 1.4645383125269 0.7625 17.2 17 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 3.28116265556295e-08 2.11271242482628e-07 1.46339503515569 0.761904761904762 17.2 17 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000104133419730288 0.000390981151124537 1.46339503515569 0.761904761904762 17.2 17 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000104133419730288 0.000390981151124537 1.46339503515569 0.761904761904762 17.2 17 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000104133419730288 0.000390981151124537 1.46339503515569 0.761904761904762 17.2 17 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000104133419730288 0.000390981151124537 1.46339503515569 0.761904761904762 17.2 17 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.08486404539859e-10 1.16072295985127e-09 1.45708729793519 0.758620689655172 17.2 17 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.08486404539859e-10 1.16072295985127e-09 1.45708729793519 0.758620689655172 17.2 17 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 7.35289080312459e-08 4.52950805750921e-07 1.45224110958286 0.75609756097561 17.2 17 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.39841695365648e-12 4.83594732505317e-11 1.44748856738226 0.753623188405797 17.2 17 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.17196313884384e-14 3.2700069540682e-13 1.44617862297739 0.752941176470588 17.2 17 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.17196313884384e-14 3.2700069540682e-13 1.44617862297739 0.752941176470588 17.2 17 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.17196313884384e-14 3.2700069540682e-13 1.44617862297739 0.752941176470588 17.2 17 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 6.89726006350922e-07 3.6486249332244e-06 1.44052948773138 0.75 17.2 17 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 1.24803828670854e-05 5.6023926876538e-05 1.44052948773138 0.75 17.2 17 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00103905015856911 0.00296306287704178 1.44052948773138 0.75 17.2 17 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00103905015856911 0.00296306287704178 1.44052948773138 0.75 17.2 17 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00103905015856911 0.00296306287704178 1.44052948773138 0.75 17.2 17 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00103905015856911 0.00296306287704178 1.44052948773138 0.75 17.2 17 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0225837949078965 0.0429061951320917 1.44052948773138 0.75 17.2 17 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.06872541635319e-13 2.57762079232303e-12 1.44052948773138 0.75 17.2 17 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 9.3115432437187e-09 6.52725420483335e-08 1.44052948773138 0.75 17.2 17 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 5.37468610838374e-05 0.000212449398117502 1.44052948773138 0.75 17.2 17 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 5.37468610838374e-05 0.000212449398117502 1.44052948773138 0.75 17.2 17 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000234280281753182 0.000790001992736441 1.44052948773138 0.75 17.2 17 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000234280281753182 0.000790001992736441 1.44052948773138 0.75 17.2 17 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00473292505711516 0.0112436600271701 1.44052948773138 0.75 17.2 17 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00473292505711516 0.0112436600271701 1.44052948773138 0.75 17.2 17 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00473292505711516 0.0112436600271701 1.44052948773138 0.75 17.2 17 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00473292505711516 0.0112436600271701 1.44052948773138 0.75 17.2 17 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00473292505711516 0.0112436600271701 1.44052948773138 0.75 17.2 17 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.00473292505711516 0.0112436600271701 1.44052948773138 0.75 17.2 17 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00473292505711516 0.0112436600271701 1.44052948773138 0.75 17.2 17 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.35535671330382e-13 5.40592355327634e-12 1.43445130423884 0.746835443037975 17.2 17 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.35535671330382e-13 5.40592355327634e-12 1.43445130423884 0.746835443037975 17.2 17 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.65889488194092e-11 1.99670307658526e-10 1.43336267435958 0.746268656716418 17.2 17 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.65889488194092e-11 1.99670307658526e-10 1.43336267435958 0.746268656716418 17.2 17 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 8.59642726958929e-08 5.18335423924812e-07 1.42936259247765 0.744186046511628 17.2 17 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.85718986825541e-40 6.09864575836383e-38 1.4276511909062 0.743295019157088 17.2 17 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 1.52326941175318e-06 7.74147276044562e-06 1.4268101592768 0.742857142857143 17.2 17 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.93846753066305e-15 1.21835636872468e-13 1.42503992334717 0.741935483870968 17.2 17 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 6.46173620958248e-06 3.02468770599864e-05 1.42503992334717 0.741935483870968 17.2 17 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.76035342287968e-05 0.000115869702677221 1.42274517306803 0.740740740740741 17.2 17 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 2.76035342287968e-05 0.000115869702677221 1.42274517306803 0.740740740740741 17.2 17 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 2.76035342287968e-05 0.000115869702677221 1.42274517306803 0.740740740740741 17.2 17 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.60575694406523e-44 5.29713161629261e-42 1.42250238378935 0.74061433447099 17.2 17 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000119007184576173 0.000439862918576347 1.41965224877875 0.739130434782609 17.2 17 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000119007184576173 0.000439862918576347 1.41965224877875 0.739130434782609 17.2 17 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.02012165067036e-20 1.48194245134618e-18 1.41836749561244 0.738461538461539 17.2 17 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.45791454668194e-12 4.48411846144666e-11 1.4152570405782 0.736842105263158 17.2 17 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000519546587030152 0.00159679221024602 1.4152570405782 0.736842105263158 17.2 17 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 3.33381240228098e-06 1.61361056069586e-05 1.41228381150135 0.735294117647059 17.2 17 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.29414625921255e-12 2.70819136302862e-11 1.41013857026869 0.734177215189873 17.2 17 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 1.41355117638817e-05 6.32541925786279e-05 1.40851772133735 0.733333333333333 17.2 17 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0023093794807763 0.00592116576782824 1.40851772133735 0.733333333333333 17.2 17 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0023093794807763 0.00592116576782824 1.40851772133735 0.733333333333333 17.2 17 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0023093794807763 0.00592116576782824 1.40851772133735 0.733333333333333 17.2 17 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0023093794807763 0.00592116576782824 1.40851772133735 0.733333333333333 17.2 17 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0023093794807763 0.00592116576782824 1.40851772133735 0.733333333333333 17.2 17 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0023093794807763 0.00592116576782824 1.40851772133735 0.733333333333333 17.2 17 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0023093794807763 0.00592116576782824 1.40851772133735 0.733333333333333 17.2 17 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0023093794807763 0.00592116576782824 1.40851772133735 0.733333333333333 17.2 17 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 5.32354476882959e-12 7.01426315374491e-11 1.40851772133735 0.733333333333333 17.2 17 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 5.32354476882959e-12 7.01426315374491e-11 1.40851772133735 0.733333333333333 17.2 17 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 5.32354476882959e-12 7.01426315374491e-11 1.40851772133735 0.733333333333333 17.2 17 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 5.32354476882959e-12 7.01426315374491e-11 1.40851772133735 0.733333333333333 17.2 17 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 5.32354476882959e-12 7.01426315374491e-11 1.40851772133735 0.733333333333333 17.2 17 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 9.78836447430675e-08 5.87714879617658e-07 1.40851772133735 0.733333333333333 17.2 17 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.25340015535044e-18 5.75351103568928e-17 1.40539462217696 0.731707317073171 17.2 17 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 6.65887386044567e-16 2.49357302721426e-14 1.40359283419981 0.730769230769231 17.2 17 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 6.03497852801123e-05 0.000237888488791135 1.40359283419981 0.730769230769231 17.2 17 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.72286066016558e-10 3.23026263379001e-09 1.4024202420242 0.73015873015873 17.2 17 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.72286066016558e-10 3.23026263379001e-09 1.4024202420242 0.73015873015873 17.2 17 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 5.07716194703538e-08 3.21102286694727e-07 1.40051477973884 0.729166666666667 17.2 17 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.5367862958856e-09 1.21491494391401e-08 1.39983656434914 0.728813559322034 17.2 17 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.5367862958856e-09 1.21491494391401e-08 1.39983656434914 0.728813559322034 17.2 17 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.5367862958856e-09 1.21491494391401e-08 1.39983656434914 0.728813559322034 17.2 17 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.65630489883093e-30 2.69994419359744e-28 1.39937150236763 0.728571428571429 17.2 17 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 4.71861423354615e-11 5.41499036640014e-10 1.39937150236763 0.728571428571429 17.2 17 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.46267021680889e-12 2.93152073030853e-11 1.3990327535169 0.728395061728395 17.2 17 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.46267021680889e-12 2.93152073030853e-11 1.3990327535169 0.728395061728395 17.2 17 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 7.38274516156853e-60 2.1011292729824e-57 1.39769684255627 0.727699530516432 17.2 17 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 6.35152616401439e-09 4.56475845019822e-08 1.39687707901225 0.727272727272727 17.2 17 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 6.35152616401439e-09 4.56475845019822e-08 1.39687707901225 0.727272727272727 17.2 17 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.11313537417346e-07 1.20279665497953e-06 1.39687707901225 0.727272727272727 17.2 17 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000259988730414578 0.000864401783598001 1.39687707901225 0.727272727272727 17.2 17 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000259988730414578 0.000864401783598001 1.39687707901225 0.727272727272727 17.2 17 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.000259988730414578 0.000864401783598001 1.39687707901225 0.727272727272727 17.2 17 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000259988730414578 0.000864401783598001 1.39687707901225 0.727272727272727 17.2 17 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0105560279634702 0.0223198035542617 1.39687707901225 0.727272727272727 17.2 17 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0105560279634702 0.0223198035542617 1.39687707901225 0.727272727272727 17.2 17 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0105560279634702 0.0223198035542617 1.39687707901225 0.727272727272727 17.2 17 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0105560279634702 0.0223198035542617 1.39687707901225 0.727272727272727 17.2 17 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0105560279634702 0.0223198035542617 1.39687707901225 0.727272727272727 17.2 17 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0105560279634702 0.0223198035542617 1.39687707901225 0.727272727272727 17.2 17 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0105560279634702 0.0223198035542617 1.39687707901225 0.727272727272727 17.2 17 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0105560279634702 0.0223198035542617 1.39687707901225 0.727272727272727 17.2 17 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.62875288182845e-08 1.75620439006661e-07 1.39345336068134 0.725490196078431 17.2 17 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.01084503532997e-10 1.09804006509508e-09 1.39181593017525 0.72463768115942 17.2 17 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.0897360455407e-07 6.46122663668505e-07 1.38944688178346 0.723404255319149 17.2 17 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 5.25604948492668e-11 5.88925859610289e-10 1.38717654374133 0.722222222222222 17.2 17 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 5.25604948492668e-11 5.88925859610289e-10 1.38717654374133 0.722222222222222 17.2 17 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.35912766378921e-08 9.38853721151479e-08 1.38717654374133 0.722222222222222 17.2 17 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.35912766378921e-08 9.38853721151479e-08 1.38717654374133 0.722222222222222 17.2 17 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.69048226579906e-06 1.7682007623677e-05 1.38717654374133 0.722222222222222 17.2 17 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00113381162811118 0.00319487910257863 1.38717654374133 0.722222222222222 17.2 17 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00113381162811118 0.00319487910257863 1.38717654374133 0.722222222222222 17.2 17 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.70663260043934e-09 1.3198577121876e-08 1.3854272668892 0.721311475409836 17.2 17 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.70663260043934e-09 1.3198577121876e-08 1.3854272668892 0.721311475409836 17.2 17 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 8.50247692883577e-13 1.80582457757213e-11 1.38469501146272 0.720930232558139 17.2 17 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 4.52587066033906e-07 2.43030715081603e-06 1.38469501146272 0.720930232558139 17.2 17 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000130296973029638 0.000476639055581427 1.38290830822213 0.72 17.2 17 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000130296973029638 0.000476639055581427 1.38290830822213 0.72 17.2 17 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000130296973029638 0.000476639055581427 1.38290830822213 0.72 17.2 17 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 1.55026869140239e-05 6.91546190553481e-05 1.38050742574257 0.71875 17.2 17 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.80217650221141e-12 3.41932955019579e-11 1.37838900002532 0.717647058823529 17.2 17 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.80217650221141e-12 3.41932955019579e-11 1.37838900002532 0.717647058823529 17.2 17 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 4.5653090607778e-10 3.86692547231358e-09 1.3760281673852 0.716417910447761 17.2 17 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 4.5653090607778e-10 3.86692547231358e-09 1.3760281673852 0.716417910447761 17.2 17 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 4.5653090607778e-10 3.86692547231358e-09 1.3760281673852 0.716417910447761 17.2 17 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.95382537256276e-15 6.46579884920189e-14 1.37445015343178 0.715596330275229 17.2 17 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 6.36358625649553e-69 4.52769162149657e-66 1.37297614039797 0.714828897338403 17.2 17 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.80278887547436e-12 5.30526330372551e-11 1.37193284545846 0.714285714285714 17.2 17 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.80278887547436e-12 5.30526330372551e-11 1.37193284545846 0.714285714285714 17.2 17 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.48574687880003e-08 1.0213612601606e-07 1.37193284545846 0.714285714285714 17.2 17 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.18990554671459e-07 6.96804770771548e-07 1.37193284545846 0.714285714285714 17.2 17 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 7.86016987860051e-06 3.64332955610701e-05 1.37193284545846 0.714285714285714 17.2 17 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 7.86016987860051e-06 3.64332955610701e-05 1.37193284545846 0.714285714285714 17.2 17 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 6.54114126330751e-05 0.000250216237034586 1.37193284545846 0.714285714285714 17.2 17 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000559647436810414 0.00169442192038557 1.37193284545846 0.714285714285714 17.2 17 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000559647436810414 0.00169442192038557 1.37193284545846 0.714285714285714 17.2 17 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000559647436810414 0.00169442192038557 1.37193284545846 0.714285714285714 17.2 17 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00503137613080621 0.0116985144825648 1.37193284545846 0.714285714285714 17.2 17 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.00503137613080621 0.0116985144825648 1.37193284545846 0.714285714285714 17.2 17 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00503137613080621 0.0116985144825648 1.37193284545846 0.714285714285714 17.2 17 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00503137613080621 0.0116985144825648 1.37193284545846 0.714285714285714 17.2 17 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00503137613080621 0.0116985144825648 1.37193284545846 0.714285714285714 17.2 17 2 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.0506785571453992 0.0862626636577788 1.37193284545846 0.714285714285714 17.2 17 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0506785571453992 0.0862626636577788 1.37193284545846 0.714285714285714 17.2 17 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0506785571453992 0.0862626636577788 1.37193284545846 0.714285714285714 17.2 17 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0506785571453992 0.0862626636577788 1.37193284545846 0.714285714285714 17.2 17 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0506785571453992 0.0862626636577788 1.37193284545846 0.714285714285714 17.2 17 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0506785571453992 0.0862626636577788 1.37193284545846 0.714285714285714 17.2 17 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0506785571453992 0.0862626636577788 1.37193284545846 0.714285714285714 17.2 17 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.21743241509834e-10 1.28190790501153e-09 1.36817412533392 0.712328767123288 17.2 17 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.21743241509834e-10 1.28190790501153e-09 1.36817412533392 0.712328767123288 17.2 17 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 7.63729551544553e-09 5.46124196908492e-08 1.36728222564335 0.711864406779661 17.2 17 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 6.73073565370537e-14 1.77367348800421e-12 1.36370124838571 0.71 17.2 17 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.12381684179691e-08 2.0297677469758e-07 1.36195515203694 0.709090909090909 17.2 17 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.12381684179691e-08 2.0297677469758e-07 1.36195515203694 0.709090909090909 17.2 17 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.12381684179691e-08 2.0297677469758e-07 1.36195515203694 0.709090909090909 17.2 17 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.12381684179691e-08 2.0297677469758e-07 1.36195515203694 0.709090909090909 17.2 17 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.55083353717611e-10 2.268647577126e-09 1.36050007174631 0.708333333333333 17.2 17 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.000277496541628988 0.000905340180531872 1.3605000717463 0.708333333333333 17.2 17 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000277496541628988 0.000905340180531872 1.3605000717463 0.708333333333333 17.2 17 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000277496541628988 0.000905340180531872 1.3605000717463 0.708333333333333 17.2 17 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.66976574921747e-11 1.99670307658526e-10 1.35854813477106 0.707317073170732 17.2 17 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.02389052328316e-06 1.00348300161392e-05 1.35854813477106 0.707317073170732 17.2 17 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.02389052328316e-06 1.00348300161392e-05 1.35854813477106 0.707317073170732 17.2 17 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 2.02389052328316e-06 1.00348300161392e-05 1.35854813477106 0.707317073170732 17.2 17 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.60015824530617e-08 1.08948573352664e-07 1.35774043671234 0.706896551724138 17.2 17 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.31271418922801e-10 1.36349802282588e-09 1.3572988951069 0.706666666666667 17.2 17 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 6.17012283388643e-16 2.3729958898974e-14 1.3557924590413 0.705882352941177 17.2 17 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 1.65680678480982e-05 7.27665449007524e-05 1.3557924590413 0.705882352941177 17.2 17 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 1.65680678480982e-05 7.27665449007524e-05 1.3557924590413 0.705882352941177 17.2 17 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.65680678480982e-05 7.27665449007524e-05 1.3557924590413 0.705882352941177 17.2 17 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 1.65680678480982e-05 7.27665449007524e-05 1.3557924590413 0.705882352941177 17.2 17 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00243019338894704 0.00618634202588844 1.3557924590413 0.705882352941177 17.2 17 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00243019338894704 0.00618634202588844 1.3557924590413 0.705882352941177 17.2 17 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00243019338894704 0.00618634202588844 1.3557924590413 0.705882352941177 17.2 17 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 8.19614198205189e-09 5.80254230868649e-08 1.35394028355081 0.704918032786885 17.2 17 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 5.31546464878364e-10 4.47568413918291e-09 1.3526098476351 0.704225352112676 17.2 17 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.92172768947357e-13 6.59939444781095e-12 1.35233380480905 0.704081632653061 17.2 17 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000138122131526988 0.000501397431538019 1.35160791441463 0.703703703703704 17.2 17 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000138122131526988 0.000501397431538019 1.35160791441463 0.703703703703704 17.2 17 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.19803456645813e-09 3.06348881439483e-08 1.35049639474817 0.703125 17.2 17 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 4.19803456645813e-09 3.06348881439483e-08 1.35049639474817 0.703125 17.2 17 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 9.18438586842631e-12 1.1464369377869e-10 1.34670189657646 0.701149425287356 17.2 17 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 9.18438586842631e-12 1.1464369377869e-10 1.34670189657646 0.701149425287356 17.2 17 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 3.99849258452149e-14 1.07355753731586e-12 1.34628924087045 0.700934579439252 17.2 17 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.70073221964537e-08 1.14698670547647e-07 1.34449418854929 0.7 17.2 17 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.70073221964537e-08 1.14698670547647e-07 1.34449418854929 0.7 17.2 17 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 2.65659419330988e-07 1.49420297908299e-06 1.34449418854929 0.7 17.2 17 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.32069474205117e-27 1.94255801055224e-25 1.34449418854929 0.7 17.2 17 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.22172794808969e-06 2.00250629004388e-05 1.34449418854929 0.7 17.2 17 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 4.22172794808969e-06 2.00250629004388e-05 1.34449418854929 0.7 17.2 17 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.22172794808969e-06 2.00250629004388e-05 1.34449418854929 0.7 17.2 17 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00118516796600975 0.00328751270103678 1.34449418854929 0.7 17.2 17 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00118516796600975 0.00328751270103678 1.34449418854929 0.7 17.2 17 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00118516796600975 0.00328751270103678 1.34449418854929 0.7 17.2 17 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00118516796600975 0.00328751270103678 1.34449418854929 0.7 17.2 17 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00118516796600975 0.00328751270103678 1.34449418854929 0.7 17.2 17 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0229286167024727 0.0429308178521297 1.34449418854929 0.7 17.2 17 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.688052294033e-09 6.12034574970741e-08 1.34144544889272 0.698412698412698 17.2 17 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.35173466537081e-07 7.85109562784761e-07 1.34087021499525 0.69811320754717 17.2 17 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 6.88174205102503e-08 4.25770388635157e-07 1.337634524322 0.696428571428571 17.2 17 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.48072565286001e-10 1.51587957123726e-09 1.33720036835824 0.69620253164557 17.2 17 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.26888122685909e-09 1.72653368225695e-08 1.33614329296824 0.695652173913043 17.2 17 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.26888122685909e-09 1.72653368225695e-08 1.33614329296824 0.695652173913043 17.2 17 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.08115489510094e-06 5.59448514810415e-06 1.33614329296824 0.695652173913043 17.2 17 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.08115489510094e-06 5.59448514810415e-06 1.33614329296824 0.695652173913043 17.2 17 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000582232263759503 0.00175162053135259 1.33614329296824 0.695652173913043 17.2 17 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.000582232263759503 0.00175162053135259 1.33614329296824 0.695652173913043 17.2 17 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000582232263759503 0.00175162053135259 1.33614329296824 0.695652173913043 17.2 17 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.15987171751644e-09 9.54044771113232e-09 1.33382359975128 0.694444444444444 17.2 17 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.73367326349675e-05 7.45322372796335e-05 1.33382359975128 0.694444444444444 17.2 17 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.73367326349675e-05 7.45322372796335e-05 1.33382359975128 0.694444444444444 17.2 17 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 7.8360909532931e-16 2.85916857090669e-14 1.33088288630301 0.692913385826772 17.2 17 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.78028324169135e-07 1.55150707957914e-06 1.32971952713666 0.692307692307692 17.2 17 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.78028324169135e-07 1.55150707957914e-06 1.32971952713666 0.692307692307692 17.2 17 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0107121143205673 0.0223837572366627 1.32971952713666 0.692307692307692 17.2 17 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0107121143205673 0.0223837572366627 1.32971952713666 0.692307692307692 17.2 17 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0107121143205673 0.0223837572366627 1.32971952713666 0.692307692307692 17.2 17 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0107121143205673 0.0223837572366627 1.32971952713666 0.692307692307692 17.2 17 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0107121143205673 0.0223837572366627 1.32971952713666 0.692307692307692 17.2 17 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0107121143205673 0.0223837572366627 1.32971952713666 0.692307692307692 17.2 17 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0107121143205673 0.0223837572366627 1.32971952713666 0.692307692307692 17.2 17 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0107121143205673 0.0223837572366627 1.32971952713666 0.692307692307692 17.2 17 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 9.1137023286951e-14 2.23599972650571e-12 1.32703322506164 0.690909090909091 17.2 17 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.41177849605968e-07 8.10064838666504e-07 1.32703322506164 0.690909090909091 17.2 17 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 2.37061742956424e-09 1.78521157325029e-08 1.3255576506824 0.690140845070423 17.2 17 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.37466294666125e-12 2.83499329434633e-11 1.32528712871287 0.69 17.2 17 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.2101169883288e-09 9.83997985366794e-09 1.32372979953695 0.689189189189189 17.2 17 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.2101169883288e-09 9.83997985366794e-09 1.32372979953695 0.689189189189189 17.2 17 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00510410398963209 0.0117717017459424 1.32048536375377 0.6875 17.2 17 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00510410398963209 0.0117717017459424 1.32048536375377 0.6875 17.2 17 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00510410398963209 0.0117717017459424 1.32048536375377 0.6875 17.2 17 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00510410398963209 0.0117717017459424 1.32048536375377 0.6875 17.2 17 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.79019001749507e-12 4.83594732505317e-11 1.3192727968449 0.686868686868687 17.2 17 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.00995165852204e-25 7.18580605038428e-24 1.31779379146727 0.68609865470852 17.2 17 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.25183499186642e-09 1.01213704171927e-08 1.31416725196547 0.684210526315789 17.2 17 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00246471921712008 0.00624073922769016 1.31416725196547 0.684210526315789 17.2 17 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00246471921712008 0.00624073922769016 1.31416725196547 0.684210526315789 17.2 17 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00246471921712008 0.00624073922769016 1.31416725196547 0.684210526315789 17.2 17 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.02416718051448e-21 2.64792218439708e-19 1.31195763909962 0.683060109289617 17.2 17 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.78206789838328e-15 6.03781576047479e-14 1.30957226157398 0.681818181818182 17.2 17 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.000590295624902604 0.0017609867384411 1.30608006887645 0.68 17.2 17 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000590295624902604 0.0017609867384411 1.30608006887645 0.68 17.2 17 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000590295624902604 0.0017609867384411 1.30608006887645 0.68 17.2 17 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000291622538080803 0.000947440346321879 1.30333620318554 0.678571428571429 17.2 17 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.5588043631624e-08 4.5966575251197e-07 1.30112340827351 0.67741935483871 17.2 17 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000144740162374307 0.000521431015338325 1.30112340827351 0.67741935483871 17.2 17 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 3.83829606479065e-08 2.46031319828698e-07 1.3001702043114 0.676923076923077 17.2 17 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.6589190072946e-15 1.15703149941783e-13 1.29972585359222 0.676691729323308 17.2 17 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 7.21130823759132e-05 0.00027437678133937 1.29930110658125 0.676470588235294 17.2 17 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 3.60432124810607e-05 0.000148602984899578 1.29777431327152 0.675675675675676 17.2 17 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 3.60432124810607e-05 0.000148602984899578 1.29777431327152 0.675675675675676 17.2 17 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.80636509749615e-05 7.6959806399312e-05 1.29647653895824 0.675 17.2 17 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.4229313022814e-14 3.89390623682006e-13 1.29535984943287 0.674418604651163 17.2 17 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.57562007655704e-12 3.07137995745298e-11 1.29211129808633 0.672727272727273 17.2 17 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 5.88047699395944e-07 3.13405197093793e-06 1.29211129808633 0.672727272727273 17.2 17 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.9771877176043e-07 1.6495495395005e-06 1.2915091958971 0.672413793103448 17.2 17 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 7.65508127170655e-08 4.63539602112273e-07 1.29047433275936 0.671875 17.2 17 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.14680540856144e-12 7.95173099671176e-11 1.28047065576123 0.666666666666667 17.2 17 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 3.46806417830308e-10 3.04633044797857e-09 1.28047065576123 0.666666666666667 17.2 17 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.90703165098666e-08 2.49314172168341e-07 1.28047065576123 0.666666666666667 17.2 17 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.16678115165157e-06 6.01568687971079e-06 1.28047065576123 0.666666666666667 17.2 17 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 2.30933383277265e-06 1.14103543195677e-05 1.28047065576123 0.666666666666667 17.2 17 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 9.08809467267237e-06 4.14498676897846e-05 1.28047065576123 0.666666666666667 17.2 17 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00502295691061876 0.0116985144825648 1.28047065576123 0.666666666666667 17.2 17 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00502295691061876 0.0116985144825648 1.28047065576123 0.666666666666667 17.2 17 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00502295691061876 0.0116985144825648 1.28047065576123 0.666666666666667 17.2 17 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.010475369430866 0.0223198035542617 1.28047065576123 0.666666666666667 17.2 17 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.010475369430866 0.0223198035542617 1.28047065576123 0.666666666666667 17.2 17 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.010475369430866 0.0223198035542617 1.28047065576123 0.666666666666667 17.2 17 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.010475369430866 0.0223198035542617 1.28047065576123 0.666666666666667 17.2 17 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0222022337761802 0.0429061951320917 1.28047065576123 0.666666666666667 17.2 17 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0222022337761802 0.0429061951320917 1.28047065576123 0.666666666666667 17.2 17 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0222022337761802 0.0429061951320917 1.28047065576123 0.666666666666667 17.2 17 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0222022337761802 0.0429061951320917 1.28047065576123 0.666666666666667 17.2 17 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0482299158795052 0.0848345739141358 1.28047065576123 0.666666666666667 17.2 17 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0482299158795052 0.0848345739141358 1.28047065576123 0.666666666666667 17.2 17 2 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.0482299158795052 0.0848345739141358 1.28047065576123 0.666666666666667 17.2 17 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0482299158795052 0.0848345739141358 1.28047065576123 0.666666666666667 17.2 17 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0482299158795052 0.0848345739141358 1.28047065576123 0.666666666666667 17.2 17 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0482299158795052 0.0848345739141358 1.28047065576123 0.666666666666667 17.2 17 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.97915833908383e-07 1.6495495395005e-06 1.27014427950509 0.661290322580645 17.2 17 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 8.23545146351691e-13 1.7756132473613e-11 1.2698882536475 0.661157024793388 17.2 17 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 8.23545146351691e-13 1.7756132473613e-11 1.2698882536475 0.661157024793388 17.2 17 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 6.12202217502762e-12 7.95173099671176e-11 1.26362235765911 0.657894736842105 17.2 17 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.19693895282532e-11 1.46831390506072e-10 1.26316699825094 0.657657657657658 17.2 17 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000142159514166628 0.000513433981368305 1.26217821782178 0.657142857142857 17.2 17 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000142159514166628 0.000513433981368305 1.26217821782178 0.657142857142857 17.2 17 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 4.47481773093064e-06 2.11550353193166e-05 1.25584622007351 0.653846153846154 17.2 17 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00116190641939383 0.00326112985167145 1.25584622007351 0.653846153846154 17.2 17 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00116190641939383 0.00326112985167145 1.25584622007351 0.653846153846154 17.2 17 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 8.85895413538233e-06 4.05347001114118e-05 1.25433860156202 0.653061224489796 17.2 17 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 7.50046305000899e-08 4.58075490135742e-07 1.2537941837662 0.652777777777778 17.2 17 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.50046305000899e-08 4.58075490135742e-07 1.2537941837662 0.652777777777778 17.2 17 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 6.63039859353437e-10 5.48549837127872e-09 1.25351337879783 0.652631578947368 17.2 17 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 6.63039859353437e-10 5.48549837127872e-09 1.25351337879783 0.652631578947368 17.2 17 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.756480986183e-05 7.50592325326852e-05 1.25263433715772 0.652173913043478 17.2 17 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 1.756480986183e-05 7.50592325326852e-05 1.25263433715772 0.652173913043478 17.2 17 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00236341255961237 0.00604880588548274 1.25263433715772 0.652173913043478 17.2 17 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00484102868346781 0.0114622026898081 1.2484588893672 0.65 17.2 17 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.00484102868346781 0.0114622026898081 1.2484588893672 0.65 17.2 17 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.25006521379056e-47 2.96473799870662e-45 1.244502378914 0.647940074906367 17.2 17 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0100062734242214 0.0216068696246844 1.24280975412119 0.647058823529412 17.2 17 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0100062734242214 0.0216068696246844 1.24280975412119 0.647058823529412 17.2 17 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0100062734242214 0.0216068696246844 1.24280975412119 0.647058823529412 17.2 17 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 6.72217126210122e-05 0.000256451734744505 1.23473956091261 0.642857142857143 17.2 17 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00111809191681843 0.0031757381190272 1.23473956091261 0.642857142857143 17.2 17 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0209374430621373 0.0409257987327217 1.23473956091261 0.642857142857143 17.2 17 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0209374430621373 0.0409257987327217 1.23473956091261 0.642857142857143 17.2 17 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0209374430621373 0.0409257987327217 1.23473956091261 0.642857142857143 17.2 17 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0209374430621373 0.0409257987327217 1.23473956091261 0.642857142857143 17.2 17 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0209374430621373 0.0409257987327217 1.23473956091261 0.642857142857143 17.2 17 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0209374430621373 0.0409257987327217 1.23473956091261 0.642857142857143 17.2 17 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0209374430621373 0.0409257987327217 1.23473956091261 0.642857142857143 17.2 17 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0209374430621373 0.0409257987327217 1.23473956091261 0.642857142857143 17.2 17 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.37108213172386e-09 1.78521157325029e-08 1.23329542107529 0.642105263157895 17.2 17 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00226087363356354 0.00589235014754746 1.22925182953078 0.64 17.2 17 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00226087363356354 0.00589235014754746 1.22925182953078 0.64 17.2 17 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.08860952599997e-23 7.0413243431725e-22 1.22868691600618 0.639705882352941 17.2 17 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.76559803358222e-08 1.18511603857901e-07 1.22835847791048 0.63953488372093 17.2 17 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000266238543979604 0.000883117594599013 1.22711771177118 0.638888888888889 17.2 17 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.18297434841025e-16 2.91109312444695e-14 1.22621342458491 0.638418079096045 17.2 17 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.96735350678851e-11 2.29470822963939e-10 1.22367558635246 0.637096774193548 17.2 17 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.96735350678851e-11 2.29470822963939e-10 1.22367558635246 0.637096774193548 17.2 17 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.96735350678851e-11 2.29470822963939e-10 1.22367558635246 0.637096774193548 17.2 17 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 6.46083238500974e-05 0.000249697650705529 1.22226744413572 0.636363636363636 17.2 17 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 6.46083238500974e-05 0.000249697650705529 1.22226744413572 0.636363636363636 17.2 17 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00459647165372055 0.0111999643206239 1.22226744413572 0.636363636363636 17.2 17 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0445806469957271 0.0791000756545133 1.22226744413572 0.636363636363636 17.2 17 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.58812727647838e-05 7.06220348258979e-05 1.21890956654194 0.634615384615385 17.2 17 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000127996674270783 0.000471863387272859 1.21800867255336 0.634146341463415 17.2 17 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00106481871132963 0.00303047405244412 1.21644712297317 0.633333333333333 17.2 17 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.58525683447261e-13 3.75970079242421e-12 1.21438184772194 0.632258064516129 17.2 17 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.2003544497804e-08 2.07004744638069e-07 1.21423941494599 0.632183908045977 17.2 17 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000253980027424857 0.000852390516569744 1.21307746335274 0.631578947368421 17.2 17 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00940850724233081 0.0207892947295602 1.21307746335274 0.631578947368421 17.2 17 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.77876793749137e-21 1.05466115627093e-19 1.21152223583562 0.630769230769231 17.2 17 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.92527081244305e-06 9.68077867882141e-06 1.21152223583562 0.630769230769231 17.2 17 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 6.16986272415632e-05 0.000241951334102255 1.21087985925247 0.630434782608696 17.2 17 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 4.00183188420236e-09 2.95057345659065e-08 1.21004476969436 0.63 17.2 17 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00213960403767813 0.00560710229395208 1.20933339710783 0.62962962962963 17.2 17 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00213960403767813 0.00560710229395208 1.20933339710783 0.62962962962963 17.2 17 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00213960403767813 0.00560710229395208 1.20933339710783 0.62962962962963 17.2 17 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.000504870998798037 0.00155504638807274 1.20730090400344 0.628571428571429 17.2 17 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.15338017833732e-17 8.75502855364001e-16 1.20730090400344 0.628571428571429 17.2 17 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.15338017833732e-17 8.75502855364001e-16 1.20730090400344 0.628571428571429 17.2 17 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.36481120370133e-07 1.33536759637579e-06 1.20659734869808 0.628205128205128 17.2 17 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 5.96500012780535e-08 3.73929303165947e-07 1.20602468740302 0.627906976744186 17.2 17 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.22515442783955e-10 1.28190790501153e-09 1.2023931767514 0.626016260162602 17.2 17 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.25932224674253e-15 7.30685353889687e-14 1.20172513415024 0.625668449197861 17.2 17 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.69063537363663e-08 3.58308590118802e-07 1.20044123977615 0.625 17.2 17 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00100564777978793 0.00289098341543077 1.20044123977615 0.625 17.2 17 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0194274784995893 0.0388822811602187 1.20044123977615 0.625 17.2 17 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0194274784995893 0.0388822811602187 1.20044123977615 0.625 17.2 17 2 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 48%5605118 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS 0.0975031608745705 0.156246619284362 1.20044123977615 0.625 17.2 17 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0975031608745705 0.156246619284362 1.20044123977615 0.625 17.2 17 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0975031608745705 0.156246619284362 1.20044123977615 0.625 17.2 17 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0975031608745705 0.156246619284362 1.20044123977615 0.625 17.2 17 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0975031608745705 0.156246619284362 1.20044123977615 0.625 17.2 17 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.10455007497933e-07 6.49493701113877e-07 1.19761667215315 0.623529411764706 17.2 17 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.10455007497933e-07 6.49493701113877e-07 1.19761667215315 0.623529411764706 17.2 17 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 8.0268923493942e-15 2.37963912774749e-13 1.19650536685885 0.622950819672131 17.2 17 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.25914445190247e-10 2.268647577126e-09 1.19650536685885 0.622950819672131 17.2 17 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 2.14342547649582e-07 1.2151770729297e-06 1.19458542885041 0.621951219512195 17.2 17 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.52491854813459e-74 2.16995909399552e-71 1.19395236820979 0.621621621621622 17.2 17 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00200779177997328 0.00536038968649526 1.19216233467425 0.620689655172414 17.2 17 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00200779177997328 0.00536038968649526 1.19216233467425 0.620689655172414 17.2 17 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00200779177997328 0.00536038968649526 1.19216233467425 0.620689655172414 17.2 17 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00874886062943935 0.0193919449777137 1.189008466064 0.619047619047619 17.2 17 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 8.06471399051933e-07 4.25040296611445e-06 1.18780501619956 0.618421052631579 17.2 17 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.77944078095439e-64 1.34453605782453e-61 1.18631840166114 0.617647058823529 17.2 17 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000943310427442217 0.00271726870091149 1.18631840166114 0.617647058823529 17.2 17 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 3.93354427505317e-07 2.13642500129796e-06 1.18562097755669 0.617283950617284 17.2 17 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.40411001908227e-24 2.30668978912099e-22 1.18423896537426 0.616564417177914 17.2 17 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.51221905923333e-12 2.98873294623476e-11 1.1838313609868 0.616352201257862 17.2 17 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.22119789262278e-35 1.73776460120222e-33 1.18287380699894 0.615853658536585 17.2 17 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 5.20992047739838e-05 0.000207087062551338 1.18197291301036 0.615384615384615 17.2 17 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00401922117623505 0.00989507220377591 1.18197291301036 0.615384615384615 17.2 17 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00401922117623505 0.00989507220377591 1.18197291301036 0.615384615384615 17.2 17 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0405864249051611 0.0730145166119396 1.18197291301036 0.615384615384615 17.2 17 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0405864249051611 0.0730145166119396 1.18197291301036 0.615384615384615 17.2 17 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0405864249051611 0.0730145166119396 1.18197291301036 0.615384615384615 17.2 17 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 5.71683859441313e-09 4.15054148971933e-08 1.18061743948627 0.614678899082569 17.2 17 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 3.71102579584374e-07 2.023291075665e-06 1.1801928333221 0.614457831325301 17.2 17 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 3.03004590095387e-06 1.47662853323882e-05 1.17986224709427 0.614285714285714 17.2 17 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 3.03004590095387e-06 1.47662853323882e-05 1.17986224709427 0.614285714285714 17.2 17 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00187142597788568 0.0050246022010025 1.17720689319984 0.612903225806452 17.2 17 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.00918755078189e-11 1.24875989979359e-10 1.17516879262297 0.611842105263158 17.2 17 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 8.00243052446731e-11 8.75958356639768e-10 1.17453243603998 0.611510791366906 17.2 17 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 8.00243052446731e-11 8.75958356639768e-10 1.17453243603998 0.611510791366906 17.2 17 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.96392110179166e-12 6.85792206587333e-11 1.17444442311858 0.611464968152866 17.2 17 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0178371993741683 0.0358507552393242 1.17376476778113 0.611111111111111 17.2 17 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0178371993741683 0.0358507552393242 1.17376476778113 0.611111111111111 17.2 17 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00041671641469927 0.00131482806677841 1.17116218514746 0.609756097560976 17.2 17 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00041671641469927 0.00131482806677841 1.17116218514746 0.609756097560976 17.2 17 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00041671641469927 0.00131482806677841 1.17116218514746 0.609756097560976 17.2 17 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00041671641469927 0.00131482806677841 1.17116218514746 0.609756097560976 17.2 17 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 8.39945385371388e-12 1.06718061016383e-10 1.1670112305672 0.607594936708861 17.2 17 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.35354265719984e-10 1.39571826173577e-09 1.16614291863969 0.607142857142857 17.2 17 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00371830458809769 0.00918601984177606 1.16614291863969 0.607142857142857 17.2 17 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.02204802752231e-19 9.59124781054751e-18 1.16490471210047 0.606498194945848 17.2 17 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00173481020415068 0.00467544492520154 1.16406423251021 0.606060606060606 17.2 17 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00173481020415068 0.00467544492520154 1.16406423251021 0.606060606060606 17.2 17 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000387294008214003 0.00123292924762534 1.16135710638809 0.604651162790698 17.2 17 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 5.94438017696806e-16 2.34968138661821e-14 1.15407226484918 0.600858369098712 17.2 17 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.02311368403522e-10 3.46963077114068e-09 1.15242359018511 0.6 17.2 17 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 9.20574947608824e-06 4.18523370749954e-05 1.15242359018511 0.6 17.2 17 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 4.7579092231733e-11 5.41640385966049e-10 1.15242359018511 0.6 17.2 17 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000171200830776166 0.00060752813514834 1.15242359018511 0.6 17.2 17 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00342225138293875 0.00848408313226802 1.15242359018511 0.6 17.2 17 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00342225138293875 0.00848408313226802 1.15242359018511 0.6 17.2 17 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0162597250806253 0.0328658931672298 1.15242359018511 0.6 17.2 17 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0366305535090442 0.0676951657706102 1.15242359018511 0.6 17.2 17 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.086181864645054 0.139359992488536 1.15242359018511 0.6 17.2 17 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.07222412733533e-13 6.83089833312216e-12 1.15042285478548 0.598958333333333 17.2 17 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.70958078382142e-08 1.79336439785017e-07 1.14899375807146 0.598214285714286 17.2 17 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 7.14601302573475e-15 2.16356947566395e-13 1.14553316513168 0.596412556053812 17.2 17 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000696069984916347 0.00203389648570013 1.14327737121538 0.595238095238095 17.2 17 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 3.5522796258905e-06 1.71352335852277e-05 1.13819613845443 0.592592592592593 17.2 17 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00675320974140876 0.0153511461054707 1.13819613845443 0.592592592592593 17.2 17 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00675320974140876 0.0153511461054707 1.13819613845443 0.592592592592593 17.2 17 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00675320974140876 0.0153511461054707 1.13819613845443 0.592592592592593 17.2 17 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00675320974140876 0.0153511461054707 1.13819613845443 0.592592592592593 17.2 17 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 3.39589438136538e-12 4.83594732505317e-11 1.13780952291827 0.592391304347826 17.2 17 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000304902143183749 0.000986081249432896 1.13674435766558 0.591836734693878 17.2 17 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.000304902143183749 0.000986081249432896 1.13674435766558 0.591836734693878 17.2 17 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 3.11994305079714e-05 0.000130195863967282 1.13496262669745 0.590909090909091 17.2 17 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00134914891680674 0.00372784254100192 1.13272404163493 0.58974358974359 17.2 17 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.87362766479229e-05 0.00012026976961763 1.12982704920108 0.588235294117647 17.2 17 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000586288621917689 0.0017601027615799 1.12737090344195 0.58695652173913 17.2 17 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.11851641186339e-26 3.83349939688505e-24 1.12400058683973 0.585201793721973 17.2 17 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.16958596247635e-10 5.16430636741402e-09 1.12041182379107 0.583333333333333 17.2 17 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.90027212368517e-12 8.84602453333693e-11 1.12041182379107 0.583333333333333 17.2 17 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.000536239561748185 0.00164454503527515 1.12041182379107 0.583333333333333 17.2 17 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0133255210164282 0.0274814730527207 1.12041182379107 0.583333333333333 17.2 17 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0759104255030925 0.125459390814054 1.12041182379107 0.583333333333333 17.2 17 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0759104255030925 0.125459390814054 1.12041182379107 0.583333333333333 17.2 17 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0759104255030925 0.125459390814054 1.12041182379107 0.583333333333333 17.2 17 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0759104255030925 0.125459390814054 1.12041182379107 0.583333333333333 17.2 17 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.08133071189896e-05 4.86941013617793e-05 1.1183857626269 0.582278481012658 17.2 17 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00112492550811404 0.0031824433360761 1.11668952537316 0.581395348837209 17.2 17 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.47899874298551e-43 4.40951901408548e-41 1.11651794695697 0.581306017925736 17.2 17 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00556954809762762 0.0128036622664364 1.11524863566301 0.580645161290323 17.2 17 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.10932203951369e-21 1.70175587008769e-19 1.11442031671198 0.580213903743315 17.2 17 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 9.71135902532622e-07 5.06200142602169e-06 1.11400947051227 0.58 17.2 17 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.45837114782551e-31 1.77447612231172e-29 1.11340399402005 0.57968476357268 17.2 17 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.012008595691947 0.0249463236053147 1.10809960594722 0.576923076923077 17.2 17 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0050394865620606 0.0116985144825648 1.1058610208847 0.575757575757576 17.2 17 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0050394865620606 0.0116985144825648 1.1058610208847 0.575757575757576 17.2 17 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0050394865620606 0.0116985144825648 1.1058610208847 0.575757575757576 17.2 17 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0050394865620606 0.0116985144825648 1.1058610208847 0.575757575757576 17.2 17 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.40031177209889e-09 1.12578737383995e-08 1.10440594059406 0.575 17.2 17 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00215257644186281 0.00563072844994627 1.10440594059406 0.575 17.2 17 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 6.81137746341034e-08 4.23257210935935e-07 1.104027848865 0.574803149606299 17.2 17 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.26988222297722e-08 8.85805099655192e-08 1.10138385075966 0.573426573426573 17.2 17 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00455159697150181 0.011109644065947 1.09754627636677 0.571428571428571 17.2 17 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0107997499458235 0.0225007967392487 1.09754627636677 0.571428571428571 17.2 17 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0107997499458235 0.0225007967392487 1.09754627636677 0.571428571428571 17.2 17 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0667850673625262 0.111152223224415 1.09754627636677 0.571428571428571 17.2 17 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0667850673625262 0.111152223224415 1.09754627636677 0.571428571428571 17.2 17 2 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.0667850673625262 0.111152223224415 1.09754627636677 0.571428571428571 17.2 17 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0667850673625262 0.111152223224415 1.09754627636677 0.571428571428571 17.2 17 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0667850673625262 0.111152223224415 1.09754627636677 0.571428571428571 17.2 17 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0667850673625262 0.111152223224415 1.09754627636677 0.571428571428571 17.2 17 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 7.41479418459925e-14 1.85109686397978e-12 1.09754627636677 0.571428571428571 17.2 17 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 7.41479418459925e-14 1.85109686397978e-12 1.09754627636677 0.571428571428571 17.2 17 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 7.41479418459925e-14 1.85109686397978e-12 1.09754627636677 0.571428571428571 17.2 17 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00176348180827109 0.00474373272810918 1.09131021797832 0.568181818181818 17.2 17 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00159321654324993 0.00438519756488326 1.08561642553669 0.565217391304348 17.2 17 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00159321654324993 0.00438519756488326 1.08561642553669 0.565217391304348 17.2 17 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0234263835046764 0.0438051822958667 1.08561642553669 0.565217391304348 17.2 17 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0587487928069149 0.0991690773004033 1.08039711579854 0.5625 17.2 17 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.26540098908427e-06 1.58589269879417e-05 1.07925383842732 0.561904761904762 17.2 17 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 7.71113726887256e-09 5.48647416680282e-08 1.07746921033567 0.560975609756098 17.2 17 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00779317225755976 0.0176306583823649 1.07333569674103 0.558823529411765 17.2 17 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0185778281301197 0.0372866705629906 1.06705887980102 0.555555555555556 17.2 17 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0516977722914765 0.0877875059317077 1.06705887980102 0.555555555555556 17.2 17 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.159094717118402 0.230776536655949 1.06705887980102 0.555555555555556 17.2 17 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00268772985570618 0.0067933207542982 1.06705887980102 0.555555555555556 17.2 17 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.38476454313327e-68 6.56839981626214e-66 1.0651300451571 0.554551323434474 17.2 17 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00558568385122858 0.0128200453553198 1.05638829100301 0.55 17.2 17 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0147100400178589 0.0297757993533616 1.05329037812617 0.548387096774194 17.2 17 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.23926011903145e-26 9.79703971878753e-25 1.04847247318552 0.545878693623639 17.2 17 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0130868403523652 0.0270676945078716 1.04765780925919 0.545454545454545 17.2 17 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0130868403523652 0.0270676945078716 1.04765780925919 0.545454545454545 17.2 17 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.136103325824247 0.200699515697309 1.04765780925919 0.545454545454545 17.2 17 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.136103325824247 0.200699515697309 1.04765780925919 0.545454545454545 17.2 17 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.136103325824247 0.200699515697309 1.04765780925919 0.545454545454545 17.2 17 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.136103325824247 0.200699515697309 1.04765780925919 0.545454545454545 17.2 17 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00356626042012015 0.00882571926579299 1.040382407806 0.541666666666667 17.2 17 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00112434045233884 0.0031824433360761 1.0390704501669 0.540983606557377 17.2 17 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.01035804980319 0.0222987970800898 1.03821945061721 0.540540540540541 17.2 17 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.03120382379204 0.057816459968845 1.03422629888407 0.538461538461538 17.2 17 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.03120382379204 0.057816459968845 1.03422629888407 0.538461538461538 17.2 17 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.03120382379204 0.057816459968845 1.03422629888407 0.538461538461538 17.2 17 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.03120382379204 0.057816459968845 1.03422629888407 0.538461538461538 17.2 17 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.03120382379204 0.057816459968845 1.03422629888407 0.538461538461538 17.2 17 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.117121759534012 0.177585848985502 1.03422629888407 0.538461538461538 17.2 17 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.117121759534012 0.177585848985502 1.03422629888407 0.538461538461538 17.2 17 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0275525337273846 0.0513856559555285 1.02894963409384 0.535714285714286 17.2 17 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00203016078018115 0.00537973703947444 1.02658423263616 0.53448275862069 17.2 17 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00203016078018115 0.00537973703947444 1.02658423263616 0.53448275862069 17.2 17 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00203016078018115 0.00537973703947444 1.02658423263616 0.53448275862069 17.2 17 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000135533514752286 0.000494523567929494 1.02298470867881 0.532608695652174 17.2 17 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.0643669808337e-05 4.82354845135783e-05 1.02231124935775 0.532258064516129 17.2 17 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0878440489601005 0.141725716179391 1.01684434428098 0.529411764705882 17.2 17 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0878440489601005 0.141725716179391 1.01684434428098 0.529411764705882 17.2 17 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.86927195331739e-05 7.94022086438998e-05 1.015910602918 0.528925619834711 17.2 17 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000239376891984783 0.000805279709915714 1.01430540709176 0.528089887640449 17.2 17 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.076443462553734 0.125610909023052 1.01089788612729 0.526315789473684 17.2 17 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.076443462553734 0.125610909023052 1.01089788612729 0.526315789473684 17.2 17 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.076443462553734 0.125610909023052 1.01089788612729 0.526315789473684 17.2 17 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.076443462553734 0.125610909023052 1.01089788612729 0.526315789473684 17.2 17 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.076443462553734 0.125610909023052 1.01089788612729 0.526315789473684 17.2 17 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.066689445101377 0.111152223224415 1.00608408666954 0.523809523809524 17.2 17 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000375612867502265 0.00120658711809519 1.00400540054005 0.522727272727273 17.2 17 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00922946504784904 0.0204253946548821 1.00210746972618 0.521739130434783 17.2 17 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00819271356320157 0.0181875684874194 1.00036769981346 0.520833333333333 17.2 17 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0072751773452624 0.016511287659184 0.998767111493758 0.52 17.2 17 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0510675873781221 0.0868209998077274 0.998767111493758 0.52 17.2 17 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000653968039282708 0.00192670086935672 0.994247803296954 0.517647058823529 17.2 17 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000653968039282708 0.00192670086935672 0.994247803296954 0.517647058823529 17.2 17 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000653968039282708 0.00192670086935672 0.994247803296954 0.517647058823529 17.2 17 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000653968039282708 0.00192670086935672 0.994247803296954 0.517647058823529 17.2 17 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000653968039282708 0.00192670086935672 0.994247803296954 0.517647058823529 17.2 17 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.93155406354169e-05 0.000196571468695233 0.982345808427507 0.511450381679389 17.2 17 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.93155406354169e-05 0.000196571468695233 0.982345808427507 0.511450381679389 17.2 17 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000230116152677028 0.000779655441093837 0.977813955308574 0.509090909090909 17.2 17 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00792569247069417 0.0177018321634755 0.977813955308574 0.509090909090909 17.2 17 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00172575297924239 0.00466871956171467 0.972209201596488 0.506172839506173 17.2 17 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00329109642872999 0.00818746541622863 0.960352991820921 0.5 17.2 17 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0477196195493068 0.0845641576820219 0.960352991820921 0.5 17.2 17 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.123990325628724 0.183981473795281 0.960352991820921 0.5 17.2 17 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.14374594501181 0.210659608395269 0.960352991820921 0.5 17.2 17 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.14374594501181 0.210659608395269 0.960352991820921 0.5 17.2 17 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.14374594501181 0.210659608395269 0.960352991820921 0.5 17.2 17 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.14374594501181 0.210659608395269 0.960352991820921 0.5 17.2 17 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.167458451705499 0.241676852714934 0.960352991820921 0.5 17.2 17 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00750633898251041 0.0170087904014527 0.960352991820921 0.5 17.2 17 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.107367364527243 0.170967310797274 0.960352991820921 0.5 17.2 17 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.107367364527243 0.170967310797274 0.960352991820921 0.5 17.2 17 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.232007569591749 0.318367185659652 0.960352991820921 0.5 17.2 17 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.232007569591749 0.318367185659652 0.960352991820921 0.5 17.2 17 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.232007569591749 0.318367185659652 0.960352991820921 0.5 17.2 17 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.232007569591749 0.318367185659652 0.960352991820921 0.5 17.2 17 2 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.232007569591749 0.318367185659652 0.960352991820921 0.5 17.2 17 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.232007569591749 0.318367185659652 0.960352991820921 0.5 17.2 17 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.232007569591749 0.318367185659652 0.960352991820921 0.5 17.2 17 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0174586252211971 0.0351892686823845 0.960352991820921 0.5 17.2 17 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0174586252211971 0.0351892686823845 0.960352991820921 0.5 17.2 17 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0812449635169131 0.133039796414922 0.960352991820921 0.5 17.2 17 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.196296226145401 0.278494047661919 0.960352991820921 0.5 17.2 17 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.196296226145401 0.278494047661919 0.960352991820921 0.5 17.2 17 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.196296226145401 0.278494047661919 0.960352991820921 0.5 17.2 17 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 5.01937870992682e-06 2.35728577697223e-05 0.955478103537566 0.49746192893401 17.2 17 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 3.71173902343831e-05 0.000150908703724363 0.954388066405885 0.496894409937888 17.2 17 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 4.88783218695514e-05 0.000195926343719357 0.948496782045354 0.493827160493827 17.2 17 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 8.94259743963783e-05 0.000339341764176124 0.942002297709693 0.490445859872611 17.2 17 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.000218900966344096 0.000765346621886114 0.939919949441753 0.48936170212766 17.2 17 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00227705495305838 0.00592116576782824 0.939919949441753 0.48936170212766 17.2 17 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0434818151077862 0.0781245238615907 0.935728556133205 0.487179487179487 17.2 17 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0131345469304024 0.0271269379999456 0.930341960826518 0.484375 17.2 17 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.095195201962151 0.153411973264033 0.92478436249422 0.481481481481481 17.2 17 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.109101003029643 0.170967310797274 0.921938872148084 0.48 17.2 17 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.109101003029643 0.170967310797274 0.921938872148084 0.48 17.2 17 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.109101003029643 0.170967310797274 0.921938872148084 0.48 17.2 17 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.125325153585209 0.185575123362906 0.918598513915664 0.478260869565217 17.2 17 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.125325153585209 0.185575123362906 0.918598513915664 0.478260869565217 17.2 17 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0501679915443035 0.0861146585856983 0.914621896972306 0.476190476190476 17.2 17 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0501679915443035 0.0861146585856983 0.914621896972306 0.476190476190476 17.2 17 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0645867759162259 0.108380875151874 0.909808097514557 0.473684210526316 17.2 17 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00614729312985472 0.0140863093780729 0.908721110540227 0.473118279569892 17.2 17 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0733920713795169 0.121863381065406 0.90700004783087 0.472222222222222 17.2 17 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000617858687866952 0.00183935755823153 0.904590560037771 0.470967741935484 17.2 17 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0834919713308523 0.13656215540667 0.903861639360867 0.470588235294118 17.2 17 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.193436519279997 0.275811790516469 0.903861639360867 0.470588235294118 17.2 17 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.193436519279997 0.275811790516469 0.903861639360867 0.470588235294118 17.2 17 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.108474096295788 0.170967310797274 0.89632945903286 0.466666666666667 17.2 17 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.225393149152118 0.311998493427494 0.89632945903286 0.466666666666667 17.2 17 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.225393149152118 0.311998493427494 0.89632945903286 0.466666666666667 17.2 17 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0569009905855284 0.0963929876228653 0.89632945903286 0.466666666666667 17.2 17 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0109343243022711 0.022747870587912 0.894874378742222 0.465909090909091 17.2 17 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000869234004010297 0.00252948872741647 0.893913476663499 0.465408805031447 17.2 17 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000869234004010297 0.00252948872741647 0.893913476663499 0.465408805031447 17.2 17 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0729389745439119 0.121252524271012 0.890083260712073 0.463414634146341 17.2 17 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.141817847657163 0.208693688951543 0.886479684757773 0.461538461538462 17.2 17 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.264160054669448 0.361442074802523 0.886479684757773 0.461538461538462 17.2 17 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.264160054669448 0.361442074802523 0.886479684757773 0.461538461538462 17.2 17 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0636373778807574 0.107040175797066 0.880323575835844 0.458333333333333 17.2 17 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.0636373778807574 0.107040175797066 0.880323575835844 0.458333333333333 17.2 17 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.16262377595069 0.235176456481537 0.880323575835844 0.458333333333333 17.2 17 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.16262377595069 0.235176456481537 0.880323575835844 0.458333333333333 17.2 17 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.16262377595069 0.235176456481537 0.880323575835844 0.458333333333333 17.2 17 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00284881374705601 0.00718769851429203 0.879196400962815 0.457746478873239 17.2 17 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.31182356732661e-07 7.65051203404005e-07 0.873048174382656 0.454545454545455 17.2 17 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.121070707360112 0.179836760515073 0.873048174382656 0.454545454545455 17.2 17 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.121070707360112 0.179836760515073 0.873048174382656 0.454545454545455 17.2 17 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.186910256552664 0.267824519077567 0.873048174382656 0.454545454545455 17.2 17 2 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.311927772731335 0.415222844337409 0.873048174382656 0.454545454545455 17.2 17 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.311927772731335 0.415222844337409 0.873048174382656 0.454545454545455 17.2 17 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0555138318865632 0.094155164212848 0.873048174382656 0.454545454545455 17.2 17 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00201338531097282 0.00536525711145005 0.871976949628812 0.45398773006135 17.2 17 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0624805583796534 0.105343405893657 0.869753652969891 0.452830188679245 17.2 17 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.137778030867373 0.202958734911254 0.867415605515671 0.451612903225806 17.2 17 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0052745128044765 0.0121450351468771 0.864317692638829 0.45 17.2 17 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.215394887925375 0.304678852403389 0.864317692638829 0.45 17.2 17 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0792223456692654 0.129877186506181 0.862357788573888 0.448979591836735 17.2 17 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0144859794057441 0.029364029479165 0.861625114157088 0.448598130841121 17.2 17 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00651207728309564 0.0148982089611657 0.861493125015826 0.448529411764706 17.2 17 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00787444928579584 0.0177018321634755 0.85520485403031 0.445255474452555 17.2 17 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00787444928579584 0.0177018321634755 0.85520485403031 0.445255474452555 17.2 17 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0769944379952801 0.126370340562034 0.853647103840819 0.444444444444444 17.2 17 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.179115964213172 0.257977750076258 0.853647103840819 0.444444444444444 17.2 17 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.204677383245799 0.290095534221885 0.845110632802411 0.44 17.2 17 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.170971614913837 0.246497069931499 0.840308867843306 0.4375 17.2 17 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.288896530150134 0.385285625495446 0.840308867843306 0.4375 17.2 17 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.288896530150134 0.385285625495446 0.840308867843306 0.4375 17.2 17 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.288896530150134 0.385285625495446 0.840308867843306 0.4375 17.2 17 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.288896530150134 0.385285625495446 0.840308867843306 0.4375 17.2 17 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00124327224904125 0.00344197745211226 0.836072016408802 0.435294117647059 17.2 17 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0214524898906228 0.0418750248482253 0.834405058467358 0.434426229508197 17.2 17 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.194082401619809 0.276179257504988 0.832305926244798 0.433333333333333 17.2 17 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.194082401619809 0.276179257504988 0.832305926244798 0.433333333333333 17.2 17 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0580649184375788 0.0982477751922409 0.829934684289685 0.432098765432099 17.2 17 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0645289015205981 0.108380875151874 0.826632954985097 0.430379746835443 17.2 17 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0101103621270135 0.021798553495061 0.826350248776141 0.430232558139535 17.2 17 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.22051187255958 0.309909943167758 0.823159707275075 0.428571428571429 17.2 17 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.22051187255958 0.309909943167758 0.823159707275075 0.428571428571429 17.2 17 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0317086953393969 0.0586755181637994 0.816678134776846 0.425196850393701 17.2 17 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.108891117803524 0.170967310797274 0.807253239501644 0.420289855072464 17.2 17 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.234746669385457 0.321815520747115 0.805457347978837 0.419354838709677 17.2 17 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.394521734578431 0.503953705839414 0.800294159850768 0.416666666666667 17.2 17 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.394521734578431 0.503953705839414 0.800294159850768 0.416666666666667 17.2 17 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.265354039557353 0.362378885115273 0.794774889782831 0.413793103448276 17.2 17 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.265354039557353 0.362378885115273 0.794774889782831 0.413793103448276 17.2 17 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.109332574016528 0.170967310797274 0.790878934440759 0.411764705882353 17.2 17 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.109332574016528 0.170967310797274 0.790878934440759 0.411764705882353 17.2 17 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.355718537759231 0.458503151477705 0.790878934440759 0.411764705882353 17.2 17 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.231825791137366 0.318367185659652 0.78798194200691 0.41025641025641 17.2 17 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.231825791137366 0.318367185659652 0.78798194200691 0.41025641025641 17.2 17 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0584591943912866 0.0987974271007135 0.768282393456737 0.4 17.2 17 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.31286846484905 0.416085818205792 0.768282393456737 0.4 17.2 17 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.339329856984768 0.442516777096766 0.768282393456737 0.4 17.2 17 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.210865169838781 0.298568295204563 0.757461514675656 0.394366197183099 17.2 17 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.324299226353977 0.430884966481521 0.756641751131635 0.393939393939394 17.2 17 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.351498609250078 0.453474633692531 0.754563065002152 0.392857142857143 17.2 17 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.423634487296277 0.532536992422794 0.746941215860716 0.388888888888889 17.2 17 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.423634487296277 0.532536992422794 0.746941215860716 0.388888888888889 17.2 17 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.423634487296277 0.532536992422794 0.746941215860716 0.388888888888889 17.2 17 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.362208546194477 0.466445937768996 0.743499090442003 0.387096774193548 17.2 17 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.343925041703338 0.444106473996234 0.738733070631478 0.384615384615385 17.2 17 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.475997784521546 0.590021644054146 0.738733070631478 0.384615384615385 17.2 17 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.475997784521546 0.590021644054146 0.738733070631478 0.384615384615385 17.2 17 2 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.475997784521546 0.590021644054146 0.738733070631478 0.384615384615385 17.2 17 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.380349267566949 0.486723927830727 0.726753615432048 0.378378378378378 17.2 17 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.484072741194086 0.599508712549334 0.720264743865691 0.375 17.2 17 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.165566984214607 0.239189663489732 0.717372114372254 0.373493975903614 17.2 17 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.408005205136872 0.520709781981856 0.705565463378636 0.36734693877551 17.2 17 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.456985382905057 0.571432513070207 0.704258860668676 0.366666666666667 17.2 17 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.432914611302826 0.543722411194989 0.702697311088479 0.365853658536585 17.2 17 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0128748849411359 0.0267069406286244 0.701760381340361 0.365365853658537 17.2 17 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.462907252856612 0.578329254446848 0.698438539506125 0.363636363636364 17.2 17 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.453256278670166 0.56726797233742 0.68855497526783 0.358490566037736 17.2 17 2 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.553393077648844 0.672455159668076 0.685966422729229 0.357142857142857 17.2 17 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.334173799368407 0.442516777096766 0.685428409848657 0.356862745098039 17.2 17 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.509112643095875 0.629971557500374 0.68154083290517 0.354838709677419 17.2 17 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.40880116034306 0.521258110365747 0.67927406738553 0.353658536585366 17.2 17 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.554084124885826 0.672455159668076 0.67789622952065 0.352941176470588 17.2 17 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.554084124885826 0.672455159668076 0.67789622952065 0.352941176470588 17.2 17 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.55502501776142 0.672455159668076 0.672247094274645 0.35 17.2 17 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.557271528503227 0.672455159668076 0.66485976356833 0.346153846153846 17.2 17 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.558481942256348 0.672455159668076 0.662312408152359 0.344827586206897 17.2 17 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.610734218084024 0.723023953688491 0.640235327880614 0.333333333333333 17.2 17 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.61552054966287 0.728084573707618 0.640235327880614 0.333333333333333 17.2 17 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.6193089436806 0.731957331276988 0.640235327880614 0.333333333333333 17.2 17 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.624648785446964 0.737655785635709 0.640235327880614 0.333333333333333 17.2 17 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.641085902839846 0.755186456739322 0.629739666767817 0.327868852459016 17.2 17 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.653793064614185 0.766980652057696 0.621404877060596 0.323529411764706 17.2 17 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.691317084387866 0.800442808042257 0.620834257338777 0.323232323232323 17.2 17 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.683154296677515 0.793574338099677 0.612991271375056 0.319148936170213 17.2 17 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.671216123424483 0.780343581399542 0.611133722067859 0.318181818181818 17.2 17 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.671216123424483 0.780343581399542 0.611133722067859 0.318181818181818 17.2 17 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.83527577694624 0.924623743480724 0.601880216072098 0.313364055299539 17.2 17 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.68854698738009 0.797884660457547 0.600220619888076 0.3125 17.2 17 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.68854698738009 0.797884660457547 0.600220619888076 0.3125 17.2 17 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.68854698738009 0.797884660457547 0.600220619888076 0.3125 17.2 17 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.737380869259175 0.842129194988609 0.598252683429426 0.311475409836066 17.2 17 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.785490703363255 0.886879771041019 0.594032778445931 0.309278350515464 17.2 17 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.807561839872189 0.90452893555517 0.586320773953826 0.305263157894737 17.2 17 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.925812486725232 1 0.583071459319845 0.303571428571429 17.2 17 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.77631200300089 0.878832124320021 0.579835768646594 0.30188679245283 17.2 17 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.731701778342586 0.836314562716064 0.576211795092553 0.3 17.2 17 2 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.731701778342586 0.836314562716064 0.576211795092553 0.3 17.2 17 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.771174045938244 0.87371072242844 0.571020697839467 0.297297297297297 17.2 17 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.785913837865583 0.886879771041019 0.557624317831503 0.290322580645161 17.2 17 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.785913837865583 0.886879771041019 0.557624317831503 0.290322580645161 17.2 17 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.81072446357563 0.90452893555517 0.548773138183384 0.285714285714286 17.2 17 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.994546656548536 1 0.54453004690877 0.283505154639175 17.2 17 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.805663993217029 0.90452893555517 0.537797675419716 0.28 17.2 17 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.907910798207041 0.987734759823104 0.534880147343298 0.278481012658228 17.2 17 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.980908261196402 1 0.526645189063086 0.274193548387097 17.2 17 2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.85241560257849 0.942492154210716 0.501053734863089 0.260869565217391 17.2 17 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.996856226310586 1 0.480176495910461 0.25 17.2 17 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.881093938517863 0.965201443041508 0.480176495910461 0.25 17.2 17 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.956836322734848 1 0.4717523468594 0.245614035087719 17.2 17 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.990823799757601 1 0.461708169144674 0.240384615384615 17.2 17 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.895299658608394 0.98000878015365 0.457310948486153 0.238095238095238 17.2 17 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.972883405882004 1 0.457310948486153 0.238095238095238 17.2 17 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.957344774937129 1 0.446675810149266 0.232558139534884 17.2 17 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.917951447990063 0.996142430079883 0.436524087191328 0.227272727272727 17.2 17 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.985694045244994 1 0.400147079925384 0.208333333333333 17.2 17 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.387044026930346 0.201511335012594 17.2 17 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.978895527398419 1 0.384141196728368 0.2 17.2 17 2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.978219894735315 1 0.371749545221002 0.193548387096774 17.2 17 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.98327878504447 1 0.360132371932845 0.1875 17.2 17 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.990606283556001 1 0.320117663940307 0.166666666666667 17.2 17 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.317802165466959 0.165461121157324 17.2 17 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.992988281406133 1 0.309791287684168 0.161290322580645 17.2 17 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.996862423396243 1 0.303269365838186 0.157894736842105 17.2 17 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999995353055653 1 0.302333349276957 0.157407407407407 17.2 17 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999993875096777 1 0.277435308748266 0.144444444444444 17.2 17 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.99995666091908 1 0.204330423791685 0.106382978723404 17.2 17 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0309791287684168 0.0161290322580645 17.2 17 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 4.75141834511463e-09 2.86494419707547e-08 1.08904489192684 1 17.5 17 5 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 3.96637716342702e-07 1.75284307563871e-06 1.08904489192684 1 17.5 17 5 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 3.96637716342702e-07 1.75284307563871e-06 1.08904489192684 1 17.5 17 5 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 3.96637716342702e-07 1.75284307563871e-06 1.08904489192684 1 17.5 17 5 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 3.96637716342702e-07 1.75284307563871e-06 1.08904489192684 1 17.5 17 5 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 7.57114941010661e-06 2.83519621331098e-05 1.08904489192684 1 17.5 17 5 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 7.57114941010661e-06 2.83519621331098e-05 1.08904489192684 1 17.5 17 5 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 7.57114941010661e-06 2.83519621331098e-05 1.08904489192684 1 17.5 17 5 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 7.57114941010661e-06 2.83519621331098e-05 1.08904489192684 1 17.5 17 5 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 7.57114941010661e-06 2.83519621331098e-05 1.08904489192684 1 17.5 17 5 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 6.91179853561791e-05 0.000227147559265226 1.08904489192684 1 17.5 17 5 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 6.91179853561791e-05 0.000227147559265226 1.08904489192684 1 17.5 17 5 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 6.91179853561791e-05 0.000227147559265226 1.08904489192684 1 17.5 17 5 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 6.91179853561791e-05 0.000227147559265226 1.08904489192684 1 17.5 17 5 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000630804386559609 0.00172290718248431 1.08904489192684 1 17.5 17 5 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000630804386559609 0.00172290718248431 1.08904489192684 1 17.5 17 5 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.000630804386559609 0.00172290718248431 1.08904489192684 1 17.5 17 5 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000630804386559609 0.00172290718248431 1.08904489192684 1 17.5 17 5 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.000630804386559609 0.00172290718248431 1.08904489192684 1 17.5 17 5 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00275440219083234 0.00638357380709188 1.08904489192684 1 17.5 17 5 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0251259041082234 0.0461344019948411 1.08904489192684 1 17.5 17 5 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 9.93390467997045e-09 5.54350837631292e-08 1.08904489192684 1 17.5 17 5 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.07683853623804e-08 1.11103054025065e-07 1.08904489192684 1 17.5 17 5 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 2.07683853623804e-08 1.11103054025065e-07 1.08904489192684 1 17.5 17 5 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 9.07666506198709e-08 4.30536479440254e-07 1.08904489192684 1 17.5 17 5 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.89743603154858e-07 8.59889004106251e-07 1.08904489192684 1 17.5 17 5 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 1.89743603154858e-07 8.59889004106251e-07 1.08904489192684 1 17.5 17 5 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.89743603154858e-07 8.59889004106251e-07 1.08904489192684 1 17.5 17 5 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 1.73302904411847e-06 7.0661900566779e-06 1.08904489192684 1 17.5 17 5 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 3.62235333491093e-06 1.42000242302431e-05 1.08904489192684 1 17.5 17 5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 3.62235333491093e-06 1.42000242302431e-05 1.08904489192684 1 17.5 17 5 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 3.62235333491093e-06 1.42000242302431e-05 1.08904489192684 1 17.5 17 5 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 3.62235333491093e-06 1.42000242302431e-05 1.08904489192684 1 17.5 17 5 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 1.58240942645035e-05 5.72969112936094e-05 1.08904489192684 1 17.5 17 5 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 1.58240942645035e-05 5.72969112936094e-05 1.08904489192684 1 17.5 17 5 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 1.58240942645035e-05 5.72969112936094e-05 1.08904489192684 1 17.5 17 5 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 1.58240942645035e-05 5.72969112936094e-05 1.08904489192684 1 17.5 17 5 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 3.30721131900964e-05 0.000116201523628413 1.08904489192684 1 17.5 17 5 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 3.30721131900964e-05 0.000116201523628413 1.08904489192684 1 17.5 17 5 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 3.30721131900964e-05 0.000116201523628413 1.08904489192684 1 17.5 17 5 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000144446238947356 0.000452746691678606 1.08904489192684 1 17.5 17 5 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.000144446238947356 0.000452746691678606 1.08904489192684 1 17.5 17 5 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000144446238947356 0.000452746691678606 1.08904489192684 1 17.5 17 5 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.000144446238947356 0.000452746691678606 1.08904489192684 1 17.5 17 5 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000144446238947356 0.000452746691678606 1.08904489192684 1 17.5 17 5 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000301861307704072 0.000882603248942325 1.08904489192684 1 17.5 17 5 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.000301861307704072 0.000882603248942325 1.08904489192684 1 17.5 17 5 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000301861307704072 0.000882603248942325 1.08904489192684 1 17.5 17 5 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.000301861307704072 0.000882603248942325 1.08904489192684 1 17.5 17 5 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000301861307704072 0.000882603248942325 1.08904489192684 1 17.5 17 5 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000301861307704072 0.000882603248942325 1.08904489192684 1 17.5 17 5 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000301861307704072 0.000882603248942325 1.08904489192684 1 17.5 17 5 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00131815962847623 0.00326784172704124 1.08904489192684 1 17.5 17 5 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00131815962847623 0.00326784172704124 1.08904489192684 1 17.5 17 5 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00131815962847623 0.00326784172704124 1.08904489192684 1 17.5 17 5 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00131815962847623 0.00326784172704124 1.08904489192684 1 17.5 17 5 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00131815962847623 0.00326784172704124 1.08904489192684 1 17.5 17 5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00131815962847623 0.00326784172704124 1.08904489192684 1 17.5 17 5 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00131815962847623 0.00326784172704124 1.08904489192684 1 17.5 17 5 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00131815962847623 0.00326784172704124 1.08904489192684 1 17.5 17 5 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00575536342449855 0.012465574053366 1.08904489192684 1 17.5 17 5 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00575536342449855 0.012465574053366 1.08904489192684 1 17.5 17 5 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00575536342449855 0.012465574053366 1.08904489192684 1 17.5 17 5 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00575536342449855 0.012465574053366 1.08904489192684 1 17.5 17 5 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00575536342449855 0.012465574053366 1.08904489192684 1 17.5 17 5 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00575536342449855 0.012465574053366 1.08904489192684 1 17.5 17 5 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00575536342449855 0.012465574053366 1.08904489192684 1 17.5 17 5 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0120255292695214 0.0240679720823193 1.08904489192684 1 17.5 17 5 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.47284321446619e-16 3.53852847645575e-15 1.06924407570999 0.981818181818182 17.5 17 5 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.10333208796745e-14 1.85381562362388e-13 1.06681948596915 0.979591836734694 17.5 17 5 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.26208778762866e-14 3.61679878853436e-13 1.06635645667837 0.979166666666667 17.5 17 5 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.19753378291191e-10 8.87547173481069e-10 1.05879364492887 0.972222222222222 17.5 17 5 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.19753378291191e-10 8.87547173481069e-10 1.05879364492887 0.972222222222222 17.5 17 5 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.19753378291191e-10 8.87547173481069e-10 1.05879364492887 0.972222222222222 17.5 17 5 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.00616083084291e-09 6.81793743947361e-09 1.05604353156542 0.96969696969697 17.5 17 5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 8.38514082097451e-09 4.75380692758834e-08 1.05274339552928 0.966666666666667 17.5 17 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.69651428045853e-08 9.21427412630718e-08 1.05149161979143 0.96551724137931 17.5 17 5 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.69651428045853e-08 9.21427412630718e-08 1.05149161979143 0.96551724137931 17.5 17 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 3.42850860619542e-08 1.75495242684032e-07 1.05015043150088 0.964285714285714 17.5 17 5 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.9202113644753e-08 3.33812229547402e-07 1.04870989592955 0.962962962962963 17.5 17 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 6.9202113644753e-08 3.33812229547402e-07 1.04870989592955 0.962962962962963 17.5 17 5 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.39496063051366e-07 6.46589243394444e-07 1.04715854992966 0.961538461538462 17.5 17 5 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.01880411471765e-25 6.04065939684676e-24 1.04504307811162 0.95959595959596 17.5 17 5 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 5.64363198091091e-07 2.43360251782916e-06 1.04366802142989 0.958333333333333 17.5 17 5 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.13243324128335e-06 4.7256671623056e-06 1.04169511401698 0.956521739130435 17.5 17 5 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.13243324128335e-06 4.7256671623056e-06 1.04169511401698 0.956521739130435 17.5 17 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.13243324128335e-06 4.7256671623056e-06 1.04169511401698 0.956521739130435 17.5 17 5 KINESINS%REACTOME%REACT_199117.2 KINESINS 2.26825960638959e-06 9.0160151393642e-06 1.03954285138471 0.954545454545455 17.5 17 5 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 2.26825960638959e-06 9.0160151393642e-06 1.03954285138471 0.954545454545455 17.5 17 5 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 4.53451998009962e-06 1.7439518734275e-05 1.0371856113589 0.952380952380952 17.5 17 5 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 7.59567108179263e-11 6.27631986728643e-10 1.03592075085724 0.951219512195122 17.5 17 5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 7.59567108179263e-11 6.27631986728643e-10 1.03592075085724 0.951219512195122 17.5 17 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 9.04588310909326e-06 3.35215928756243e-05 1.0345926473305 0.95 17.5 17 5 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 9.04588310909326e-06 3.35215928756243e-05 1.0345926473305 0.95 17.5 17 5 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 9.04588310909326e-06 3.35215928756243e-05 1.0345926473305 0.95 17.5 17 5 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 1.80037520906068e-05 6.45323406169608e-05 1.03172673972017 0.947368421052632 17.5 17 5 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 1.80037520906068e-05 6.45323406169608e-05 1.03172673972017 0.947368421052632 17.5 17 5 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.18621500600179e-09 7.69411740834589e-09 1.03017760047134 0.945945945945946 17.5 17 5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.18621500600179e-09 7.69411740834589e-09 1.03017760047134 0.945945945945946 17.5 17 5 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.72074937913091e-13 2.1344328947031e-12 1.02854239793091 0.944444444444444 17.5 17 5 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 3.57408662783828e-05 0.000124046957839363 1.02854239793091 0.944444444444444 17.5 17 5 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.60538953958459e-25 8.78642044164952e-24 1.02797695406179 0.94392523364486 17.5 17 5 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 4.64820216941455e-09 2.81463476045826e-08 1.02681375524531 0.942857142857143 17.5 17 5 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 4.64820216941455e-09 2.81463476045826e-08 1.02681375524531 0.942857142857143 17.5 17 5 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 6.72549611824219e-13 7.71804917440212e-12 1.02621537893106 0.942307692307692 17.5 17 5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 9.17927124154318e-09 5.1833741971095e-08 1.02498342769585 0.941176470588235 17.5 17 5 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 7.07518866132377e-05 0.000230917281308801 1.02498342769585 0.941176470588235 17.5 17 5 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 7.07518866132377e-05 0.000230917281308801 1.02498342769585 0.941176470588235 17.5 17 5 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 7.07518866132377e-05 0.000230917281308801 1.02498342769585 0.941176470588235 17.5 17 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.32737277770763e-12 1.43094807778634e-11 1.02498342769585 0.941176470588235 17.5 17 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.32737277770763e-12 1.43094807778634e-11 1.02498342769585 0.941176470588235 17.5 17 5 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.20486107038573e-19 4.08218405514023e-18 1.02343977795535 0.939759036144578 17.5 17 5 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 3.56103506488493e-08 1.81625551875672e-07 1.02097958618142 0.9375 17.5 17 5 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000139618267080458 0.000443474986731007 1.02097958618142 0.9375 17.5 17 5 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000139618267080458 0.000443474986731007 1.02097958618142 0.9375 17.5 17 5 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000139618267080458 0.000443474986731007 1.02097958618142 0.9375 17.5 17 5 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000139618267080458 0.000443474986731007 1.02097958618142 0.9375 17.5 17 5 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.000139618267080458 0.000443474986731007 1.02097958618142 0.9375 17.5 17 5 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000139618267080458 0.000443474986731007 1.02097958618142 0.9375 17.5 17 5 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000139618267080458 0.000443474986731007 1.02097958618142 0.9375 17.5 17 5 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.9893446651058e-11 1.92573976765003e-10 1.01953138818683 0.936170212765957 17.5 17 5 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 6.9940465726405e-08 3.36234063272548e-07 1.01878393115737 0.935483870967742 17.5 17 5 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000274544378148398 0.000825954862801628 1.01644189913172 0.933333333333333 17.5 17 5 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000274544378148398 0.000825954862801628 1.01644189913172 0.933333333333333 17.5 17 5 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000274544378148398 0.000825954862801628 1.01644189913172 0.933333333333333 17.5 17 5 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000274544378148398 0.000825954862801628 1.01644189913172 0.933333333333333 17.5 17 5 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000274544378148398 0.000825954862801628 1.01644189913172 0.933333333333333 17.5 17 5 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 2.68104320036435e-07 1.20731787155648e-06 1.01393834765603 0.931034482758621 17.5 17 5 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 2.68104320036435e-07 1.20731787155648e-06 1.01393834765603 0.931034482758621 17.5 17 5 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.91566693531405e-10 2.05395744997619e-09 1.0130650157459 0.930232558139535 17.5 17 5 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.02144590601307e-37 9.9915175242566e-35 1.01217113484965 0.929411764705882 17.5 17 5 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.37035969605696e-36 1.62501820624087e-34 1.01171626054742 0.928994082840237 17.5 17 5 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 5.23123472221146e-07 2.26262827042763e-06 1.01125597107493 0.928571428571429 17.5 17 5 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000537714323515253 0.00148576210167418 1.01125597107493 0.928571428571429 17.5 17 5 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000537714323515253 0.00148576210167418 1.01125597107493 0.928571428571429 17.5 17 5 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000537714323515253 0.00148576210167418 1.01125597107493 0.928571428571429 17.5 17 5 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.10550930692972e-09 7.28305436926386e-09 1.00935868032244 0.926829268292683 17.5 17 5 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.10550930692972e-09 7.28305436926386e-09 1.00935868032244 0.926829268292683 17.5 17 5 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.10550930692972e-09 7.28305436926386e-09 1.00935868032244 0.926829268292683 17.5 17 5 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.10550930692972e-09 7.28305436926386e-09 1.00935868032244 0.926829268292683 17.5 17 5 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.10550930692972e-09 7.28305436926386e-09 1.00935868032244 0.926829268292683 17.5 17 5 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 7.49648427722838e-35 8.20576702038153e-33 1.00886980785861 0.926380368098159 17.5 17 5 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 1.01817043063402e-06 4.31207298450065e-06 1.00837489993226 0.925925925925926 17.5 17 5 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 1.01817043063402e-06 4.31207298450065e-06 1.00837489993226 0.925925925925926 17.5 17 5 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 1.01817043063402e-06 4.31207298450065e-06 1.00837489993226 0.925925925925926 17.5 17 5 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 5.53649442189177e-15 1.05045754164693e-13 1.00777288506663 0.925373134328358 17.5 17 5 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 5.53649442189177e-15 1.05045754164693e-13 1.00777288506663 0.925373134328358 17.5 17 5 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.14689363191376e-09 1.3638525170595e-08 1.00736652503233 0.925 17.5 17 5 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.97639422600646e-06 7.92227882706252e-06 1.00527220793247 0.923076923076923 17.5 17 5 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 1.97639422600646e-06 7.92227882706252e-06 1.00527220793247 0.923076923076923 17.5 17 5 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.97639422600646e-06 7.92227882706252e-06 1.00527220793247 0.923076923076923 17.5 17 5 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 1.97639422600646e-06 7.92227882706252e-06 1.00527220793247 0.923076923076923 17.5 17 5 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00104838528204148 0.00270753585543561 1.00527220793247 0.923076923076923 17.5 17 5 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00104838528204148 0.00270753585543561 1.00527220793247 0.923076923076923 17.5 17 5 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00104838528204148 0.00270753585543561 1.00527220793247 0.923076923076923 17.5 17 5 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00104838528204148 0.00270753585543561 1.00527220793247 0.923076923076923 17.5 17 5 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00104838528204148 0.00270753585543561 1.00527220793247 0.923076923076923 17.5 17 5 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00104838528204148 0.00270753585543561 1.00527220793247 0.923076923076923 17.5 17 5 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 8.04976066878149e-09 4.60032507296227e-08 1.00306766361683 0.921052631578947 17.5 17 5 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 8.04976066878149e-09 4.60032507296227e-08 1.00306766361683 0.921052631578947 17.5 17 5 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 8.04976066878149e-09 4.60032507296227e-08 1.00306766361683 0.921052631578947 17.5 17 5 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.43068789500515e-11 3.23302574476313e-10 1.0019213005727 0.92 17.5 17 5 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 3.8253868761261e-06 1.47921889258898e-05 1.0019213005727 0.92 17.5 17 5 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.8253868761261e-06 1.47921889258898e-05 1.0019213005727 0.92 17.5 17 5 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 3.8253868761261e-06 1.47921889258898e-05 1.0019213005727 0.92 17.5 17 5 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.8253868761261e-06 1.47921889258898e-05 1.0019213005727 0.92 17.5 17 5 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 3.8253868761261e-06 1.47921889258898e-05 1.0019213005727 0.92 17.5 17 5 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 5.72912430046032e-18 1.48228070537364e-16 0.999358842003456 0.917647058823529 17.5 17 5 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 5.72912430046032e-18 1.48228070537364e-16 0.999358842003456 0.917647058823529 17.5 17 5 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 5.72912430046032e-18 1.48228070537364e-16 0.999358842003456 0.917647058823529 17.5 17 5 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.99290334698328e-08 1.54308024012942e-07 0.998291150932939 0.916666666666667 17.5 17 5 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 7.3812037163982e-06 2.80092077024924e-05 0.998291150932939 0.916666666666667 17.5 17 5 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 7.3812037163982e-06 2.80092077024924e-05 0.998291150932939 0.916666666666667 17.5 17 5 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 7.3812037163982e-06 2.80092077024924e-05 0.998291150932939 0.916666666666667 17.5 17 5 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00203342706402795 0.00490435035951148 0.998291150932939 0.916666666666667 17.5 17 5 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00203342706402795 0.00490435035951148 0.998291150932939 0.916666666666667 17.5 17 5 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00203342706402795 0.00490435035951148 0.998291150932939 0.916666666666667 17.5 17 5 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00203342706402795 0.00490435035951148 0.998291150932939 0.916666666666667 17.5 17 5 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00203342706402795 0.00490435035951148 0.998291150932939 0.916666666666667 17.5 17 5 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00203342706402795 0.00490435035951148 0.998291150932939 0.916666666666667 17.5 17 5 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00203342706402795 0.00490435035951148 0.998291150932939 0.916666666666667 17.5 17 5 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00203342706402795 0.00490435035951148 0.998291150932939 0.916666666666667 17.5 17 5 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.06706886184242e-12 1.16802999261674e-11 0.996752951933043 0.915254237288136 17.5 17 5 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.06706886184242e-12 1.16802999261674e-11 0.996752951933043 0.915254237288136 17.5 17 5 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.44526941734342e-10 1.73115342332323e-09 0.996360220273494 0.914893617021277 17.5 17 5 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 5.7510674677582e-08 2.84158646063191e-07 0.995698186904542 0.914285714285714 17.5 17 5 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 5.7510674677582e-08 2.84158646063191e-07 0.995698186904542 0.914285714285714 17.5 17 5 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.04673406677265e-12 2.15740931630925e-11 0.995161711588322 0.913793103448276 17.5 17 5 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.04673406677265e-12 2.15740931630925e-11 0.995161711588322 0.913793103448276 17.5 17 5 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.49200076308746e-16 3.53852847645575e-15 0.993753463883244 0.9125 17.5 17 5 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.10237468579115e-07 5.16012887460791e-07 0.992952695580357 0.911764705882353 17.5 17 5 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 8.97287943722353e-10 6.10928585606176e-09 0.992240901533346 0.911111111111111 17.5 17 5 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 8.97287943722353e-10 6.10928585606176e-09 0.992240901533346 0.911111111111111 17.5 17 5 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 6.35913799331841e-14 8.95945877672485e-13 0.991518483694588 0.91044776119403 17.5 17 5 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 4.08215552380005e-20 1.48946341291474e-18 0.991030851653427 0.91 17.5 17 5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.71364265251313e-09 1.09350380920457e-08 0.990040810842584 0.909090909090909 17.5 17 5 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 2.71971237171999e-05 9.6512486407919e-05 0.990040810842584 0.909090909090909 17.5 17 5 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 2.71971237171999e-05 9.6512486407919e-05 0.990040810842584 0.909090909090909 17.5 17 5 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00392023517511498 0.00873003858245481 0.990040810842584 0.909090909090909 17.5 17 5 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.48469459489408e-19 4.91330327566111e-18 0.989030565117235 0.908163265306122 17.5 17 5 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 3.77228480961349e-15 7.5605088508169e-14 0.987400702013671 0.906666666666667 17.5 17 5 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 8.35639460176969e-13 9.43742025263355e-12 0.985326330790953 0.904761904761905 17.5 17 5 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 6.20963867983831e-09 3.68179826725413e-08 0.985326330790953 0.904761904761905 17.5 17 5 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 6.20963867983831e-09 3.68179826725413e-08 0.985326330790953 0.904761904761905 17.5 17 5 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 5.19038328345332e-05 0.000175021692235879 0.985326330790953 0.904761904761905 17.5 17 5 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 5.19038328345332e-05 0.000175021692235879 0.985326330790953 0.904761904761905 17.5 17 5 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 5.19038328345332e-05 0.000175021692235879 0.985326330790953 0.904761904761905 17.5 17 5 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.20873549140505e-20 1.20158700112352e-18 0.984329036933877 0.903846153846154 17.5 17 5 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.20873549140505e-20 1.20158700112352e-18 0.984329036933877 0.903846153846154 17.5 17 5 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 9.84222482867676e-11 7.44972655915267e-10 0.984329036933877 0.903846153846154 17.5 17 5 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 9.84222482867676e-11 7.44972655915267e-10 0.984329036933877 0.903846153846154 17.5 17 5 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.67726724052983e-18 1.00629832370653e-16 0.983653450772632 0.903225806451613 17.5 17 5 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 1.17796986380162e-08 6.54785592261602e-08 0.982796609787639 0.902439024390244 17.5 17 5 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.8648543734037e-10 1.34024635017852e-09 0.982275784875191 0.901960784313726 17.5 17 5 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.8648543734037e-10 1.34024635017852e-09 0.982275784875191 0.901960784313726 17.5 17 5 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.22120364448548e-48 1.1417525317892e-45 0.980557661313441 0.900383141762452 17.5 17 5 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 2.22911857276229e-08 1.18553288516689e-07 0.980140402734159 0.9 17.5 17 5 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0075043568057258 0.015589342678172 0.980140402734159 0.9 17.5 17 5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 1.44727666518815e-06 5.93508557510875e-06 0.980140402734158 0.9 17.5 17 5 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.13934360929902e-22 1.01476198534417e-20 0.97922523895943 0.899159663865546 17.5 17 5 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.73994529715784e-13 2.1344328947031e-12 0.97856207680383 0.898550724637681 17.5 17 5 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.71985457313084e-53 1.77262186536646e-50 0.97753858899918 0.897610921501707 17.5 17 5 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 6.74161411557064e-76 1.9186633772914e-73 0.976561381962568 0.896713615023474 17.5 17 5 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000186506336874477 0.000574455665308185 0.974408587513491 0.894736842105263 17.5 17 5 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000186506336874477 0.000574455665308185 0.974408587513491 0.894736842105263 17.5 17 5 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 3.56199550667288e-14 5.17216286326073e-13 0.972880103454646 0.893333333333333 17.5 17 5 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 3.56199550667288e-14 5.17216286326073e-13 0.972880103454646 0.893333333333333 17.5 17 5 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 3.56199550667288e-14 5.17216286326073e-13 0.972880103454646 0.893333333333333 17.5 17 5 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 3.56199550667288e-14 5.17216286326073e-13 0.972880103454646 0.893333333333333 17.5 17 5 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 3.56199550667288e-14 5.17216286326073e-13 0.972880103454646 0.893333333333333 17.5 17 5 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.48647781448052e-07 6.84549491911254e-07 0.971310309015833 0.891891891891892 17.5 17 5 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.41029509710103e-09 2.69349782110505e-08 0.970670447152186 0.891304347826087 17.5 17 5 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 4.41029509710103e-09 2.69349782110505e-08 0.970670447152186 0.891304347826087 17.5 17 5 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 4.41029509710103e-09 2.69349782110505e-08 0.970670447152186 0.891304347826087 17.5 17 5 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.24760996643657e-13 1.74053821788161e-12 0.969697506510203 0.89041095890411 17.5 17 5 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.1647115972903e-19 4.04240147059536e-18 0.969150041439484 0.889908256880734 17.5 17 5 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 7.20095296174029e-15 1.33077351487746e-13 0.968039903934971 0.888888888888889 17.5 17 5 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 7.20095296174029e-15 1.33077351487746e-13 0.968039903934971 0.888888888888889 17.5 17 5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.32924399720365e-13 2.80891034578033e-12 0.968039903934971 0.888888888888889 17.5 17 5 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 2.78163804339575e-07 1.24866591033191e-06 0.968039903934971 0.888888888888889 17.5 17 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 9.64218458898594e-06 3.55461882645777e-05 0.968039903934971 0.888888888888889 17.5 17 5 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 9.64218458898594e-06 3.55461882645777e-05 0.968039903934971 0.888888888888889 17.5 17 5 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000350840049292079 0.000992535566883952 0.968039903934971 0.888888888888889 17.5 17 5 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000350840049292079 0.000992535566883952 0.968039903934971 0.888888888888889 17.5 17 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000350840049292079 0.000992535566883952 0.968039903934971 0.888888888888889 17.5 17 5 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000350840049292079 0.000992535566883952 0.968039903934971 0.888888888888889 17.5 17 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0142443426896812 0.0277287272878473 0.968039903934971 0.888888888888889 17.5 17 5 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.16074821026257e-28 5.09487235160182e-26 0.966527341585073 0.8875 17.5 17 5 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.53719624223065e-08 8.41319327959315e-08 0.96528979057152 0.886363636363636 17.5 17 5 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.53719624223065e-08 8.41319327959315e-08 0.96528979057152 0.886363636363636 17.5 17 5 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.37654018000174e-21 6.12130211294525e-20 0.965088562764438 0.886178861788618 17.5 17 5 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.49776676426176e-14 3.86339359298313e-13 0.964976486517456 0.886075949367089 17.5 17 5 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.49776676426176e-14 3.86339359298313e-13 0.964976486517456 0.886075949367089 17.5 17 5 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.49776676426176e-14 3.86339359298313e-13 0.964976486517456 0.886075949367089 17.5 17 5 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 8.07743793970503e-13 9.1953553505602e-12 0.964582618563775 0.885714285714286 17.5 17 5 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 5.1887012131599e-07 2.25107372753858e-06 0.964582618563775 0.885714285714286 17.5 17 5 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 5.1887012131599e-07 2.25107372753858e-06 0.964582618563775 0.885714285714286 17.5 17 5 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 1.800099719371e-05 6.45323406169608e-05 0.963385865935284 0.884615384615385 17.5 17 5 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.800099719371e-05 6.45323406169608e-05 0.963385865935284 0.884615384615385 17.5 17 5 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.85833868681429e-08 1.48445837640027e-07 0.962411764958605 0.883720930232558 17.5 17 5 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.87774579382694e-11 4.33814516538484e-10 0.961989654535378 0.883333333333333 17.5 17 5 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.87774579382694e-11 4.33814516538484e-10 0.961989654535378 0.883333333333333 17.5 17 5 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.87774579382694e-11 4.33814516538484e-10 0.961989654535378 0.883333333333333 17.5 17 5 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.87774579382694e-11 4.33814516538484e-10 0.961989654535378 0.883333333333333 17.5 17 5 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.87774579382694e-11 4.33814516538484e-10 0.961989654535378 0.883333333333333 17.5 17 5 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.87774579382694e-11 4.33814516538484e-10 0.961989654535378 0.883333333333333 17.5 17 5 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.87774579382694e-11 4.33814516538484e-10 0.961989654535378 0.883333333333333 17.5 17 5 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 4.95946684072943e-15 9.667563444326e-14 0.960921963464861 0.882352941176471 17.5 17 5 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 9.64612235761095e-07 4.12205168615026e-06 0.960921963464861 0.882352941176471 17.5 17 5 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.000656116120584605 0.00176797643127772 0.960921963464861 0.882352941176471 17.5 17 5 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000656116120584605 0.00176797643127772 0.960921963464861 0.882352941176471 17.5 17 5 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.000656116120584605 0.00176797643127772 0.960921963464861 0.882352941176471 17.5 17 5 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000656116120584605 0.00176797643127772 0.960921963464861 0.882352941176471 17.5 17 5 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000656116120584605 0.00176797643127772 0.960921963464861 0.882352941176471 17.5 17 5 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.000656116120584605 0.00176797643127772 0.960921963464861 0.882352941176471 17.5 17 5 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 5.14634242182436e-12 5.19379096897593e-11 0.959009680950503 0.880597014925373 17.5 17 5 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 3.34571938783938e-05 0.000116690163943516 0.958359504895622 0.88 17.5 17 5 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 3.34571938783938e-05 0.000116690163943516 0.958359504895622 0.88 17.5 17 5 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 3.34571938783938e-05 0.000116690163943516 0.958359504895622 0.88 17.5 17 5 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 1.78688245341239e-06 7.26495351773095e-06 0.957039450481165 0.878787878787879 17.5 17 5 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.12729978340329e-14 4.78510493740094e-13 0.956234539252838 0.878048780487805 17.5 17 5 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 9.79738927727898e-08 4.60121615233267e-07 0.956234539252838 0.878048780487805 17.5 17 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 9.79738927727898e-08 4.60121615233267e-07 0.956234539252838 0.878048780487805 17.5 17 5 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.00208637715472e-12 1.11403821460248e-11 0.954779083333123 0.876712328767123 17.5 17 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00121902715562398 0.00308112902744746 0.952914280435987 0.875 17.5 17 5 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00121902715562398 0.00308112902744746 0.952914280435987 0.875 17.5 17 5 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00121902715562398 0.00308112902744746 0.952914280435987 0.875 17.5 17 5 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00121902715562398 0.00308112902744746 0.952914280435987 0.875 17.5 17 5 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00121902715562398 0.00308112902744746 0.952914280435987 0.875 17.5 17 5 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.026762092060162 0.0482667389120539 0.952914280435987 0.875 17.5 17 5 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.84257272193279e-12 1.97141427316569e-11 0.952914280435987 0.875 17.5 17 5 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 6.18870655052531e-05 0.000207701165598998 0.952914280435987 0.875 17.5 17 5 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.12036643451619e-14 1.85381562362388e-13 0.951349560763679 0.873563218390805 17.5 17 5 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.12036643451619e-14 1.85381562362388e-13 0.951349560763679 0.873563218390805 17.5 17 5 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.38152467689961e-12 3.51234278483807e-11 0.950996947879778 0.873239436619718 17.5 17 5 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 9.3541684637839e-82 4.43699390798816e-79 0.950326245996998 0.872623574144487 17.5 17 5 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 6.06095284835604e-06 2.32472665854735e-05 0.948522970387895 0.870967741935484 17.5 17 5 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 3.38057151610945e-08 1.73666182939486e-07 0.946995558197255 0.869565217391304 17.5 17 5 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.13213036448473e-11 1.11104931631847e-10 0.946995558197255 0.869565217391304 17.5 17 5 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.13213036448473e-11 1.11104931631847e-10 0.946995558197255 0.869565217391304 17.5 17 5 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 8.81050530904509e-21 3.68745560434446e-19 0.946631329136409 0.869230769230769 17.5 17 5 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.97857335554832e-10 1.40775494247263e-09 0.94621933232988 0.868852459016393 17.5 17 5 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.97857335554832e-10 1.40775494247263e-09 0.94621933232988 0.868852459016393 17.5 17 5 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.2011650439904e-16 9.48929818666402e-15 0.946038997027358 0.868686868686869 17.5 17 5 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.5926049417496e-18 7.23387614139153e-17 0.945749511410153 0.868421052631579 17.5 17 5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 3.60659892954474e-10 2.52817255011929e-09 0.943838906336597 0.866666666666667 17.5 17 5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.10923726099419e-05 4.07866827492181e-05 0.943838906336597 0.866666666666667 17.5 17 5 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00224831896839982 0.00533226315338823 0.943838906336597 0.866666666666667 17.5 17 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00224831896839982 0.00533226315338823 0.943838906336597 0.866666666666667 17.5 17 5 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00224831896839982 0.00533226315338823 0.943838906336597 0.866666666666667 17.5 17 5 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00224831896839982 0.00533226315338823 0.943838906336597 0.866666666666667 17.5 17 5 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.31827596892476e-14 2.15621460204591e-13 0.943838906336597 0.866666666666667 17.5 17 5 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.32783727205735e-20 1.8953781095344e-18 0.943267229227974 0.866141732283465 17.5 17 5 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.02874251843193e-20 4.18257315351037e-19 0.941655357681105 0.864661654135338 17.5 17 5 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 3.58710325019951e-33 3.40296528335594e-31 0.940538770300455 0.863636363636364 17.5 17 5 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00020837965724431 0.000637686563997105 0.940538770300455 0.863636363636364 17.5 17 5 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00020837965724431 0.000637686563997105 0.940538770300455 0.863636363636364 17.5 17 5 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 7.13763669403455e-12 7.15271620817688e-11 0.939860660156043 0.863013698630137 17.5 17 5 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.18953326060161e-09 7.69411740834589e-09 0.938831803385209 0.862068965517241 17.5 17 5 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.18953326060161e-09 7.69411740834589e-09 0.938831803385209 0.862068965517241 17.5 17 5 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.29230267976939e-11 1.25955254336428e-10 0.937788656937003 0.861111111111111 17.5 17 5 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.33474333983267e-11 2.22975823663214e-10 0.935658287430104 0.859154929577465 17.5 17 5 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.86087207559821e-27 3.79091861980739e-25 0.934317202363466 0.85792349726776 17.5 17 5 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 4.03227687250479e-10 2.81271077920309e-09 0.933467050223008 0.857142857142857 17.5 17 5 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.63546664389857e-13 5.45146201179146e-12 0.933467050223008 0.857142857142857 17.5 17 5 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.63546664389857e-13 5.45146201179146e-12 0.933467050223008 0.857142857142857 17.5 17 5 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 3.882534804959e-09 2.4338533160602e-08 0.933467050223008 0.857142857142857 17.5 17 5 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 3.66339216184539e-05 0.000125312669382355 0.933467050223008 0.857142857142857 17.5 17 5 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 3.66339216184539e-05 0.000125312669382355 0.933467050223008 0.857142857142857 17.5 17 5 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 3.66339216184539e-05 0.000125312669382355 0.933467050223008 0.857142857142857 17.5 17 5 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000378949013462402 0.00105321180890039 0.933467050223008 0.857142857142857 17.5 17 5 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000378949013462402 0.00105321180890039 0.933467050223008 0.857142857142857 17.5 17 5 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00411241103319882 0.00901688890638202 0.933467050223008 0.857142857142857 17.5 17 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00411241103319882 0.00901688890638202 0.933467050223008 0.857142857142857 17.5 17 5 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00411241103319882 0.00901688890638202 0.933467050223008 0.857142857142857 17.5 17 5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00411241103319882 0.00901688890638202 0.933467050223008 0.857142857142857 17.5 17 5 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.00411241103319882 0.00901688890638202 0.933467050223008 0.857142857142857 17.5 17 5 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.00411241103319882 0.00901688890638202 0.933467050223008 0.857142857142857 17.5 17 5 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00411241103319882 0.00901688890638202 0.933467050223008 0.857142857142857 17.5 17 5 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00411241103319882 0.00901688890638202 0.933467050223008 0.857142857142857 17.5 17 5 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0496465243396589 0.0851168724522103 0.933467050223008 0.857142857142857 17.5 17 5 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.36651973854416e-75 5.6125959799139e-73 0.93201032885874 0.855805243445693 17.5 17 5 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 7.56961778932395e-11 6.27631986728643e-10 0.931212298893967 0.855072463768116 17.5 17 5 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.25317279690213e-10 4.98611830434383e-09 0.930957730195527 0.854838709677419 17.5 17 5 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.86520381167189e-16 4.35112299017885e-15 0.930638362192029 0.854545454545454 17.5 17 5 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 6.9851878184532e-09 4.05711112884037e-08 0.930638362192029 0.854545454545454 17.5 17 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 6.9851878184532e-09 4.05711112884037e-08 0.930638362192029 0.854545454545454 17.5 17 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 6.9851878184532e-09 4.05711112884037e-08 0.930638362192029 0.854545454545454 17.5 17 5 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.30129689126351e-09 8.37893880664245e-09 0.928366137380259 0.852459016393443 17.5 17 5 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 8.65286628309988e-30 7.69564295053196e-28 0.928281122166214 0.852380952380952 17.5 17 5 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.25307226241318e-08 6.91132492020912e-08 0.927704907937681 0.851851851851852 17.5 17 5 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 6.60641696708728e-05 0.00021913592876842 0.927704907937681 0.851851851851852 17.5 17 5 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 6.60641696708728e-05 0.00021913592876842 0.927704907937681 0.851851851851852 17.5 17 5 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 6.60641696708728e-05 0.00021913592876842 0.927704907937681 0.851851851851852 17.5 17 5 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 6.60641696708728e-05 0.00021913592876842 0.927704907937681 0.851851851851852 17.5 17 5 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.07025931885359e-15 2.30754395564949e-14 0.926197057620025 0.850467289719626 17.5 17 5 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.18775831464354e-06 4.91331419109814e-06 0.925688158137816 0.85 17.5 17 5 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.18775831464354e-06 4.91331419109814e-06 0.925688158137816 0.85 17.5 17 5 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00068450299925922 0.00182748174098662 0.925688158137816 0.85 17.5 17 5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00068450299925922 0.00182748174098662 0.925688158137816 0.85 17.5 17 5 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00068450299925922 0.00182748174098662 0.925688158137816 0.85 17.5 17 5 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.32839718667434e-09 1.47258186517226e-08 0.925688158137816 0.85 17.5 17 5 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.2410987077294e-08 1.18553288516689e-07 0.924660757296376 0.849056603773585 17.5 17 5 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 2.2410987077294e-08 1.18553288516689e-07 0.924660757296376 0.849056603773585 17.5 17 5 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 8.54410795283567e-12 8.50228364817144e-11 0.923620351380993 0.848101265822785 17.5 17 5 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.15460422498575e-09 2.58166017998023e-08 0.922919399938002 0.847457627118644 17.5 17 5 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.11555063654746e-11 6.27631986728643e-10 0.92266303343802 0.847222222222222 17.5 17 5 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 3.99559429257536e-08 2.023391700475e-07 0.921499523938098 0.846153846153846 17.5 17 5 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000118466275644155 0.000382261927985561 0.921499523938098 0.846153846153846 17.5 17 5 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000118466275644155 0.000382261927985561 0.921499523938098 0.846153846153846 17.5 17 5 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00745115686495355 0.015589342678172 0.921499523938098 0.846153846153846 17.5 17 5 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00745115686495355 0.015589342678172 0.921499523938098 0.846153846153846 17.5 17 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00745115686495355 0.015589342678172 0.921499523938098 0.846153846153846 17.5 17 5 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.14368340748345e-15 2.42904699828202e-14 0.920737954083603 0.845454545454545 17.5 17 5 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.37319477334793e-09 8.80205478591941e-09 0.918881627563274 0.84375 17.5 17 5 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 4.78424566382007e-11 4.33814516538484e-10 0.917090435306815 0.842105263157895 17.5 17 5 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 4.78424566382007e-11 4.33814516538484e-10 0.917090435306815 0.842105263157895 17.5 17 5 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00122728651551928 0.00309102426829016 0.917090435306815 0.842105263157895 17.5 17 5 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00122728651551928 0.00309102426829016 0.917090435306815 0.842105263157895 17.5 17 5 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.95313801978348e-14 8.52944599939159e-13 0.914797709218548 0.84 17.5 17 5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.25749974433936e-07 5.84778475880692e-07 0.914797709218548 0.84 17.5 17 5 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000211143891546265 0.000644759136631621 0.914797709218548 0.84 17.5 17 5 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 8.13287256140393e-25 4.28632505736214e-23 0.914331807660504 0.839572192513369 17.5 17 5 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.74665612495073e-29 3.13617156812052e-27 0.91323495421668 0.838565022421525 17.5 17 5 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.49102218400552e-10 1.08806388094351e-09 0.912443017560328 0.837837837837838 17.5 17 5 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.49102218400552e-10 1.08806388094351e-09 0.912443017560328 0.837837837837838 17.5 17 5 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 4.08745671864894e-08 2.04085996864472e-07 0.910837545975178 0.836363636363636 17.5 17 5 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.08745671864894e-08 2.04085996864472e-07 0.910837545975178 0.836363636363636 17.5 17 5 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 4.08745671864894e-08 2.04085996864472e-07 0.910837545975178 0.836363636363636 17.5 17 5 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 4.08745671864894e-08 2.04085996864472e-07 0.910837545975178 0.836363636363636 17.5 17 5 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.60054034687867e-10 3.17794607456716e-09 0.907537409939036 0.833333333333333 17.5 17 5 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 7.18123093431057e-08 3.44070424899796e-07 0.907537409939036 0.833333333333333 17.5 17 5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.17781431017415e-05 4.3085598030278e-05 0.907537409939036 0.833333333333333 17.5 17 5 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000373854905864727 0.00104312849224609 0.907537409939036 0.833333333333333 17.5 17 5 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00218249647704723 0.0052108934342923 0.907537409939036 0.833333333333333 17.5 17 5 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00218249647704723 0.0052108934342923 0.907537409939036 0.833333333333333 17.5 17 5 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00218249647704723 0.0052108934342923 0.907537409939036 0.833333333333333 17.5 17 5 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00218249647704723 0.0052108934342923 0.907537409939036 0.833333333333333 17.5 17 5 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00218249647704723 0.0052108934342923 0.907537409939036 0.833333333333333 17.5 17 5 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0133542757305502 0.0264667609534441 0.907537409939036 0.833333333333333 17.5 17 5 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0133542757305502 0.0264667609534441 0.907537409939036 0.833333333333333 17.5 17 5 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0133542757305502 0.0264667609534441 0.907537409939036 0.833333333333333 17.5 17 5 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0133542757305502 0.0264667609534441 0.907537409939036 0.833333333333333 17.5 17 5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0133542757305502 0.0264667609534441 0.907537409939036 0.833333333333333 17.5 17 5 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 48%5605140 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.090627778301733 0.143292587248185 0.907537409939036 0.833333333333333 17.5 17 5 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.02620506860886e-26 6.34908614187135e-25 0.907537409939036 0.833333333333333 17.5 17 5 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 4.31908632624874e-09 2.67219993141389e-08 0.904744987139223 0.830769230769231 17.5 17 5 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.19221734489359e-06 4.91746458487995e-06 0.899645780287392 0.826086956521739 17.5 17 5 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000657244927720248 0.00176797643127772 0.899645780287392 0.826086956521739 17.5 17 5 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.000657244927720248 0.00176797643127772 0.899645780287392 0.826086956521739 17.5 17 5 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.35867078859262e-16 3.33342850373671e-15 0.899287069848681 0.825757575757576 17.5 17 5 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.79277758175073e-11 2.64941499922086e-10 0.899095201474487 0.825581395348837 17.5 17 5 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.24561154268706e-22 1.03080813717538e-20 0.898610812464225 0.825136612021858 17.5 17 5 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 3.60302937965622e-05 0.000124143118819632 0.89686049923387 0.823529411764706 17.5 17 5 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 3.60302937965622e-05 0.000124143118819632 0.89686049923387 0.823529411764706 17.5 17 5 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 3.60302937965622e-05 0.000124143118819632 0.89686049923387 0.823529411764706 17.5 17 5 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00384594531914106 0.00873003858245481 0.89686049923387 0.823529411764706 17.5 17 5 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00384594531914106 0.00873003858245481 0.89686049923387 0.823529411764706 17.5 17 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00384594531914106 0.00873003858245481 0.89686049923387 0.823529411764706 17.5 17 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00384594531914106 0.00873003858245481 0.89686049923387 0.823529411764706 17.5 17 5 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.9968619206984e-19 9.69212389353142e-18 0.896049594623352 0.822784810126582 17.5 17 5 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.27285276853671e-08 1.19787758875101e-07 0.89582724981079 0.82258064516129 17.5 17 5 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.57842924497345e-18 4.67938503249422e-17 0.895596128229311 0.822368421052632 17.5 17 5 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.07106971823268e-06 8.27846126136264e-06 0.895436911139848 0.822222222222222 17.5 17 5 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 5.99398875572143e-14 8.52944599939159e-13 0.894572589797049 0.821428571428571 17.5 17 5 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000201443310712 0.000619122745449623 0.894572589797049 0.821428571428571 17.5 17 5 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 7.3345638472027e-09 4.24271721730465e-08 0.893992075462334 0.82089552238806 17.5 17 5 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 8.93359280499846e-19 2.76358751337235e-17 0.893575295939973 0.82051282051282 17.5 17 5 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 6.24996202775116e-05 0.000209263434482115 0.891036729758326 0.818181818181818 17.5 17 5 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00114651111644381 0.00293432611276897 0.891036729758326 0.818181818181818 17.5 17 5 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00114651111644381 0.00293432611276897 0.891036729758326 0.818181818181818 17.5 17 5 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00114651111644381 0.00293432611276897 0.891036729758326 0.818181818181818 17.5 17 5 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0236329041434743 0.0445425464849854 0.891036729758326 0.818181818181818 17.5 17 5 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0236329041434743 0.0445425464849854 0.891036729758326 0.818181818181818 17.5 17 5 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0236329041434743 0.0445425464849854 0.891036729758326 0.818181818181818 17.5 17 5 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0236329041434743 0.0445425464849854 0.891036729758326 0.818181818181818 17.5 17 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0236329041434743 0.0445425464849854 0.891036729758326 0.818181818181818 17.5 17 5 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0236329041434743 0.0445425464849854 0.891036729758326 0.818181818181818 17.5 17 5 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0236329041434743 0.0445425464849854 0.891036729758326 0.818181818181818 17.5 17 5 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0236329041434743 0.0445425464849854 0.891036729758326 0.818181818181818 17.5 17 5 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 8.66600271574984e-19 2.74038263655823e-17 0.890414062581695 0.817610062893082 17.5 17 5 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.13807407397577e-06 4.73531990429098e-06 0.889016238307627 0.816326530612245 17.5 17 5 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.55109096942808e-18 7.23387614139153e-17 0.887883733545452 0.815286624203822 17.5 17 5 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 5.23889527632342e-13 6.06093331561644e-12 0.88736991194039 0.814814814814815 17.5 17 5 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000349035541926594 0.000992535566883952 0.88736991194039 0.814814814814815 17.5 17 5 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000349035541926594 0.000992535566883952 0.88736991194039 0.814814814814815 17.5 17 5 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.05797379132247e-14 1.81385145186973e-13 0.887044629714606 0.814516129032258 17.5 17 5 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.05797379132247e-14 1.81385145186973e-13 0.887044629714606 0.814516129032258 17.5 17 5 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.05797379132247e-14 1.81385145186973e-13 0.887044629714606 0.814516129032258 17.5 17 5 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.44980791057007e-15 7.01296665248745e-14 0.886431888777663 0.813953488372093 17.5 17 5 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 6.16669239915336e-06 2.35892561397721e-05 0.886431888777663 0.813953488372093 17.5 17 5 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.90879842858777e-20 1.14978337885567e-18 0.886002623940482 0.813559322033898 17.5 17 5 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.8093081426786e-14 2.92573350799052e-13 0.885402351160035 0.813008130081301 17.5 17 5 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.6700367914202e-16 8.42332637772733e-15 0.88533865314916 0.81294964028777 17.5 17 5 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 3.72543245516348e-08 1.89331799417772e-07 0.88484897469056 0.8125 17.5 17 5 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00670858349042844 0.0142908896809576 0.88484897469056 0.8125 17.5 17 5 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00670858349042844 0.0142908896809576 0.88484897469056 0.8125 17.5 17 5 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00670858349042844 0.0142908896809576 0.88484897469056 0.8125 17.5 17 5 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.19776060273496e-08 6.63195851241964e-08 0.883862520984104 0.811594202898551 17.5 17 5 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 3.36150658757224e-05 0.000116954128951474 0.883009371832575 0.810810810810811 17.5 17 5 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0019831074388957 0.00484873176211097 0.881607769655063 0.80952380952381 17.5 17 5 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0019831074388957 0.00484873176211097 0.881607769655063 0.80952380952381 17.5 17 5 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.34045396856494e-06 1.32408523600777e-05 0.880504380706809 0.808510638297872 17.5 17 5 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 4.55591655711701e-28 3.41214171619869e-26 0.879613181940912 0.807692307692308 17.5 17 5 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.0611534762759e-06 4.480775657984e-06 0.879613181940912 0.807692307692308 17.5 17 5 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.00463739627267e-15 2.19938309984e-14 0.879014805626666 0.807142857142857 17.5 17 5 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.00463739627267e-15 2.19938309984e-14 0.879014805626666 0.807142857142857 17.5 17 5 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 3.47460459422086e-17 8.82921845995765e-16 0.878262009618422 0.806451612903226 17.5 17 5 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000184655397893481 0.000571227459135703 0.878262009618422 0.806451612903226 17.5 17 5 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 5.7429570551752e-05 0.000193196876820669 0.877286162941068 0.805555555555556 17.5 17 5 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 7.69200317398883e-29 6.08095584254784e-27 0.876841291661686 0.805147058823529 17.5 17 5 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.74301018335695e-07 2.46897386432536e-06 0.87512535958407 0.803571428571429 17.5 17 5 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.06745977598034e-09 7.19902967402852e-09 0.871235913541474 0.8 17.5 17 5 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.05370103257485e-05 0.000108094939536169 0.871235913541474 0.8 17.5 17 5 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00339842058055954 0.00778736310166863 0.871235913541474 0.8 17.5 17 5 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00339842058055954 0.00778736310166863 0.871235913541474 0.8 17.5 17 5 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00339842058055954 0.00778736310166863 0.871235913541474 0.8 17.5 17 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0412042862255031 0.0725664595283303 0.871235913541474 0.8 17.5 17 5 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0412042862255031 0.0725664595283303 0.871235913541474 0.8 17.5 17 5 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0412042862255031 0.0725664595283303 0.871235913541474 0.8 17.5 17 5 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0412042862255031 0.0725664595283303 0.871235913541474 0.8 17.5 17 5 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0412042862255031 0.0725664595283303 0.871235913541474 0.8 17.5 17 5 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0412042862255031 0.0725664595283303 0.871235913541474 0.8 17.5 17 5 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0412042862255031 0.0725664595283303 0.871235913541474 0.8 17.5 17 5 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0412042862255031 0.0725664595283303 0.871235913541474 0.8 17.5 17 5 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.11669571293309e-10 8.40771428308881e-10 0.871235913541474 0.8 17.5 17 5 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000314258527222621 0.000899778439110241 0.871235913541474 0.8 17.5 17 5 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00102469896313857 0.00269495432509131 0.871235913541474 0.8 17.5 17 5 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0115687792923949 0.0236528346739626 0.871235913541474 0.8 17.5 17 5 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0115687792923949 0.0236528346739626 0.871235913541474 0.8 17.5 17 5 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.9736237876558e-88 2.1157333249171e-85 0.870989523294432 0.799773755656109 17.5 17 5 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 5.5587342198163e-09 3.32356251882294e-08 0.86847883786571 0.79746835443038 17.5 17 5 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.67033303625804e-07 7.66736745353286e-07 0.867832648254203 0.796875 17.5 17 5 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.00167754962627e-13 2.43451893428904e-12 0.866090819563867 0.795275590551181 17.5 17 5 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.96311066700153e-21 1.27772923610399e-19 0.86604998548468 0.795238095238095 17.5 17 5 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 9.31619768423036e-09 5.23990091093273e-08 0.865651067941849 0.794871794871795 17.5 17 5 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 5.14880425579492e-05 0.000174862731646687 0.865651067941849 0.794871794871795 17.5 17 5 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.000164595593846888 0.000512515383028711 0.864829767118375 0.794117647058823 17.5 17 5 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000164595593846888 0.000512515383028711 0.864829767118375 0.794117647058823 17.5 17 5 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.33944767046912e-18 4.05539156399482e-17 0.864133446854995 0.793478260869565 17.5 17 5 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.18236296385392e-16 2.95175876765635e-15 0.863267292381034 0.792682926829268 17.5 17 5 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 5.02519703834874e-09 3.01723855931235e-08 0.863267292381034 0.792682926829268 17.5 17 5 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 8.60861477477764e-06 3.21523853661643e-05 0.862160539442084 0.791666666666667 17.5 17 5 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00173412701077122 0.0042545909247025 0.862160539442084 0.791666666666667 17.5 17 5 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00173412701077122 0.0042545909247025 0.862160539442084 0.791666666666667 17.5 17 5 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.7076468854176e-09 1.7048590787386e-08 0.861105263384015 0.790697674418605 17.5 17 5 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.59204377912905e-08 1.35605819768406e-07 0.859772283100139 0.789473684210526 17.5 17 5 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000275916917522916 0.000826588997126546 0.858035369396906 0.787878787878788 17.5 17 5 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000275916917522916 0.000826588997126546 0.858035369396906 0.787878787878788 17.5 17 5 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.70643669352104e-92 5.27425941488044e-89 0.857936266212638 0.787787787787788 17.5 17 5 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000890207056380118 0.00236336686796438 0.855678129371091 0.785714285714286 17.5 17 5 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0196932249147208 0.0378695392616861 0.855678129371091 0.785714285714286 17.5 17 5 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0196932249147208 0.0378695392616861 0.855678129371091 0.785714285714286 17.5 17 5 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0196932249147208 0.0378695392616861 0.855678129371091 0.785714285714286 17.5 17 5 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0196932249147208 0.0378695392616861 0.855678129371091 0.785714285714286 17.5 17 5 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0196932249147208 0.0378695392616861 0.855678129371091 0.785714285714286 17.5 17 5 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.21467715854972e-12 4.28391828329733e-11 0.855035245727686 0.785123966942149 17.5 17 5 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.21467715854972e-12 4.28391828329733e-11 0.855035245727686 0.785123966942149 17.5 17 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.99463395098762e-09 2.49314215449797e-08 0.853910199351729 0.784090909090909 17.5 17 5 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 2.38151202561798e-05 8.5148030463678e-05 0.852296002377529 0.782608695652174 17.5 17 5 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00290786939584866 0.0066956280749072 0.852296002377529 0.782608695652174 17.5 17 5 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00290786939584866 0.0066956280749072 0.852296002377529 0.782608695652174 17.5 17 5 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00290786939584866 0.0066956280749072 0.852296002377529 0.782608695652174 17.5 17 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 6.58375933291332e-09 3.87135931022134e-08 0.851207501735923 0.781609195402299 17.5 17 5 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.12317218264318e-06 4.7256671623056e-06 0.8470349159431 0.777777777777778 17.5 17 5 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00966801626646944 0.0199674704603571 0.8470349159431 0.777777777777778 17.5 17 5 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00966801626646944 0.0199674704603571 0.8470349159431 0.777777777777778 17.5 17 5 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0705742148568447 0.114251544643106 0.8470349159431 0.777777777777778 17.5 17 5 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0705742148568447 0.114251544643106 0.8470349159431 0.777777777777778 17.5 17 5 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0705742148568447 0.114251544643106 0.8470349159431 0.777777777777778 17.5 17 5 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0705742148568447 0.114251544643106 0.8470349159431 0.777777777777778 17.5 17 5 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0705742148568447 0.114251544643106 0.8470349159431 0.777777777777778 17.5 17 5 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0705742148568447 0.114251544643106 0.8470349159431 0.777777777777778 17.5 17 5 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 5.09065249615371e-13 5.93770369018585e-12 0.846164376461144 0.776978417266187 17.5 17 5 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.77197375763336e-08 9.55120703451616e-08 0.845611327849078 0.776470588235294 17.5 17 5 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.77197375763336e-08 9.55120703451616e-08 0.845611327849078 0.776470588235294 17.5 17 5 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.72960722838192e-13 3.26405973612392e-12 0.845342538488668 0.776223776223776 17.5 17 5 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 9.43920437376008e-09 5.28818418262228e-08 0.844315702729799 0.775280898876405 17.5 17 5 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.53443656167621e-10 1.1140322588088e-09 0.843764510862239 0.774774774774775 17.5 17 5 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 4.05756922066783e-10 2.81654682976113e-09 0.839263953411512 0.770642201834862 17.5 17 5 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00243906257915007 0.00575586409640224 0.837726839943725 0.769230769230769 17.5 17 5 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00243906257915007 0.00575586409640224 0.837726839943725 0.769230769230769 17.5 17 5 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0330313386158722 0.0589756522589538 0.837726839943725 0.769230769230769 17.5 17 5 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0330313386158722 0.0589756522589538 0.837726839943725 0.769230769230769 17.5 17 5 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.58087754052309e-06 6.46433546024242e-06 0.837726839943725 0.769230769230769 17.5 17 5 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00124302767208453 0.00312513847592984 0.834934417143913 0.766666666666667 17.5 17 5 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.65695155734612e-12 2.78003093095848e-11 0.834162044880135 0.765957446808511 17.5 17 5 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.2342514586125e-07 5.75849123149374e-07 0.833589917277336 0.765432098765432 17.5 17 5 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 6.53711012379655e-08 3.17484904647184e-07 0.83279903500288 0.764705882352941 17.5 17 5 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 6.53711012379655e-08 3.17484904647184e-07 0.83279903500288 0.764705882352941 17.5 17 5 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 6.53711012379655e-08 3.17484904647184e-07 0.83279903500288 0.764705882352941 17.5 17 5 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 6.53711012379655e-08 3.17484904647184e-07 0.83279903500288 0.764705882352941 17.5 17 5 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 6.53711012379655e-08 3.17484904647184e-07 0.83279903500288 0.764705882352941 17.5 17 5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.34949801840991e-06 5.55010312195752e-06 0.83279903500288 0.764705882352941 17.5 17 5 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.11997269543622e-07 3.05172323662823e-06 0.831909292444116 0.763888888888889 17.5 17 5 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.36948290472069e-10 1.00972755099355e-09 0.830173565157347 0.762295081967213 17.5 17 5 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000170345030145865 0.000528106705659186 0.829748489087118 0.761904761904762 17.5 17 5 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 5.56812406024797e-08 2.77043375445205e-07 0.829159179080664 0.761363636363636 17.5 17 5 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.95006316018909e-08 1.52652359161785e-07 0.828621113422598 0.760869565217391 17.5 17 5 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.34691232820629e-25 7.6666249721502e-24 0.828475868705083 0.760736196319018 17.5 17 5 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.21239936868741e-15 2.5371239730032e-14 0.82812788656937 0.760416666666667 17.5 17 5 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 8.29566031806147e-09 4.72188985304059e-08 0.8276741178644 0.76 17.5 17 5 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 4.61561114967238e-05 0.000157129537463727 0.8276741178644 0.76 17.5 17 5 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00398064916160796 0.00885072462026271 0.8276741178644 0.76 17.5 17 5 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.68597702692874e-07 7.71429359909839e-07 0.826624436040857 0.759036144578313 17.5 17 5 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00103215046182344 0.00269495432509131 0.825034009035487 0.757575757575758 17.5 17 5 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00103215046182344 0.00269495432509131 0.825034009035487 0.757575757575758 17.5 17 5 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00103215046182344 0.00269495432509131 0.825034009035487 0.757575757575758 17.5 17 5 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00103215046182344 0.00269495432509131 0.825034009035487 0.757575757575758 17.5 17 5 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00103215046182344 0.00269495432509131 0.825034009035487 0.757575757575758 17.5 17 5 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 1.8338996820716e-06 7.43486965124752e-06 0.824562561030324 0.757142857142857 17.5 17 5 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000274235007143473 0.000825954862801628 0.823424186578832 0.75609756097561 17.5 17 5 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.05359743222237e-36 1.36297195095676e-34 0.823424186578832 0.75609756097561 17.5 17 5 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.42366631951861e-07 6.5775232879058e-07 0.823115325293544 0.755813953488372 17.5 17 5 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 8.40406952060864e-11 6.42956501496027e-10 0.823018658784408 0.755725190839695 17.5 17 5 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 8.40406952060864e-11 6.42956501496027e-10 0.823018658784408 0.755725190839695 17.5 17 5 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 4.28615581978859e-07 1.87667684047974e-06 0.820144918611573 0.753086419753086 17.5 17 5 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 4.28615581978859e-07 1.87667684047974e-06 0.820144918611573 0.753086419753086 17.5 17 5 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 4.28615581978859e-07 1.87667684047974e-06 0.820144918611573 0.753086419753086 17.5 17 5 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0128628735894295 0.0256716256911055 0.816783668945132 0.75 17.5 17 5 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0128628735894295 0.0256716256911055 0.816783668945132 0.75 17.5 17 5 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.81496003302305e-08 1.46728502820213e-07 0.816783668945132 0.75 17.5 17 5 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00165670966918852 0.00408578485139559 0.816783668945132 0.75 17.5 17 5 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00165670966918852 0.00408578485139559 0.816783668945132 0.75 17.5 17 5 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.006429096551081 0.0137987999882176 0.816783668945132 0.75 17.5 17 5 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.006429096551081 0.0137987999882176 0.816783668945132 0.75 17.5 17 5 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.006429096551081 0.0137987999882176 0.816783668945132 0.75 17.5 17 5 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.006429096551081 0.0137987999882176 0.816783668945132 0.75 17.5 17 5 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.054468789382247 0.0900221687467334 0.816783668945132 0.75 17.5 17 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.054468789382247 0.0900221687467334 0.816783668945132 0.75 17.5 17 5 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.054468789382247 0.0900221687467334 0.816783668945132 0.75 17.5 17 5 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.054468789382247 0.0900221687467334 0.816783668945132 0.75 17.5 17 5 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.054468789382247 0.0900221687467334 0.816783668945132 0.75 17.5 17 5 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.054468789382247 0.0900221687467334 0.816783668945132 0.75 17.5 17 5 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.118299821178149 0.177200679512112 0.816783668945132 0.75 17.5 17 5 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.118299821178149 0.177200679512112 0.816783668945132 0.75 17.5 17 5 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.118299821178149 0.177200679512112 0.816783668945132 0.75 17.5 17 5 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.118299821178149 0.177200679512112 0.816783668945132 0.75 17.5 17 5 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 8.38526709054137e-08 3.99071407018073e-07 0.813917761334798 0.747368421052632 17.5 17 5 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 8.38526709054137e-08 3.99071407018073e-07 0.813917761334798 0.747368421052632 17.5 17 5 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 2.6639564659371e-05 9.50077707024686e-05 0.812169071945442 0.745762711864407 17.5 17 5 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000360098901553698 0.00101069178877892 0.81045201259672 0.744186046511628 17.5 17 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.15488037618074e-05 4.235553544601e-05 0.808533328854777 0.742424242424242 17.5 17 5 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00517886978882169 0.0113377410915281 0.806699919945809 0.740740740740741 17.5 17 5 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.000294432393266216 0.000880204402558457 0.804946224467667 0.739130434782609 17.5 17 5 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000567015851409454 0.00156368906309235 0.803818848803146 0.738095238095238 17.5 17 5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.19963863291621e-11 2.11492282070255e-10 0.803170607796047 0.7375 17.5 17 5 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00109597268169382 0.00282019733462986 0.802454130893463 0.736842105263158 17.5 17 5 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0205977670808081 0.0394490209367293 0.802454130893463 0.736842105263158 17.5 17 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0205977670808081 0.0394490209367293 0.802454130893463 0.736842105263158 17.5 17 5 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.70640231673308e-18 4.95553162594116e-17 0.802040281419047 0.736462093862816 17.5 17 5 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.39188493281721e-11 5.64947345304279e-10 0.800974952772 0.735483870967742 17.5 17 5 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.59432377298727e-15 9.08017045689011e-14 0.800911938457409 0.73542600896861 17.5 17 5 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.01606924569976e-24 1.53280947736813e-22 0.800768302887384 0.735294117647059 17.5 17 5 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00212781502391635 0.00512331773102024 0.800768302887384 0.735294117647059 17.5 17 5 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000239884537222343 0.000730954382157162 0.800114614476864 0.73469387755102 17.5 17 5 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.67742263633041e-15 3.4593803065191e-14 0.799256122401245 0.733905579399142 17.5 17 5 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 6.32405896923951e-09 3.73408129179578e-08 0.799218428752764 0.733870967741935 17.5 17 5 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.12080744520129e-48 1.99363624315179e-46 0.799004767060283 0.733674775928297 17.5 17 5 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0420354503761172 0.0736655737502644 0.798632920746351 0.733333333333333 17.5 17 5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0420354503761172 0.0736655737502644 0.798632920746351 0.733333333333333 17.5 17 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0420354503761172 0.0736655737502644 0.798632920746351 0.733333333333333 17.5 17 5 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0420354503761172 0.0736655737502644 0.798632920746351 0.733333333333333 17.5 17 5 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00816495559970795 0.0169369268489569 0.795840497946539 0.730769230769231 17.5 17 5 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 2.30734261185561e-08 1.21156772570868e-07 0.792032648674067 0.727272727272727 17.5 17 5 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00071479506041429 0.00190122125414866 0.792032648674067 0.727272727272727 17.5 17 5 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0880613051109129 0.14111625807751 0.792032648674067 0.727272727272727 17.5 17 5 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00137452595282462 0.00340165292325119 0.789557546646961 0.725 17.5 17 5 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.93595123713143e-12 4.05859319596959e-11 0.788423124884537 0.723958333333333 17.5 17 5 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0325069248767842 0.0582586323673349 0.786532421947164 0.722222222222222 17.5 17 5 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000103212734161381 0.000335323563268595 0.785540577783296 0.721311475409836 17.5 17 5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.52186156656692e-07 1.57597767585683e-06 0.78370520260156 0.719626168224299 17.5 17 5 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 8.31047531640309e-15 1.4782257969052e-13 0.782210815233169 0.718253968253968 17.5 17 5 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 8.31047531640309e-15 1.4782257969052e-13 0.782210815233169 0.718253968253968 17.5 17 5 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 8.31047531640309e-15 1.4782257969052e-13 0.782210815233169 0.718253968253968 17.5 17 5 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.000371131310226562 0.00103756356473948 0.780824639494717 0.716981132075472 17.5 17 5 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.000705006750396276 0.00187869776369644 0.777889208519173 0.714285714285714 17.5 17 5 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0016843661040746 0.00414680443961619 0.777889208519173 0.714285714285714 17.5 17 5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0040707978246978 0.00901688890638202 0.777889208519173 0.714285714285714 17.5 17 5 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.010001296626077 0.0205960131677388 0.777889208519173 0.714285714285714 17.5 17 5 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0663766228687505 0.108443093389474 0.777889208519173 0.714285714285714 17.5 17 5 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0663766228687505 0.108443093389474 0.777889208519173 0.714285714285714 17.5 17 5 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0663766228687505 0.108443093389474 0.777889208519173 0.714285714285714 17.5 17 5 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0663766228687505 0.108443093389474 0.777889208519173 0.714285714285714 17.5 17 5 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.193080913206918 0.275029168662107 0.777889208519173 0.714285714285714 17.5 17 5 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.193080913206918 0.275029168662107 0.777889208519173 0.714285714285714 17.5 17 5 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.193080913206918 0.275029168662107 0.777889208519173 0.714285714285714 17.5 17 5 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.193080913206918 0.275029168662107 0.777889208519173 0.714285714285714 17.5 17 5 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.193080913206918 0.275029168662107 0.777889208519173 0.714285714285714 17.5 17 5 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 7.14018887959078e-34 7.25749198261263e-32 0.775711602647736 0.712286158631415 17.5 17 5 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 3.6099974663199e-23 1.7713884119218e-21 0.771610282172382 0.708520179372197 17.5 17 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00106729240425076 0.00275137154211744 0.77140679844818 0.708333333333333 17.5 17 5 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000359186384311858 0.00101012297406279 0.769842078775872 0.706896551724138 17.5 17 5 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000359186384311858 0.00101012297406279 0.769842078775872 0.706896551724138 17.5 17 5 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000359186384311858 0.00101012297406279 0.769842078775872 0.706896551724138 17.5 17 5 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00618872696461837 0.013363518164874 0.768737570771889 0.705882352941177 17.5 17 5 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0504786686611309 0.0862318673526883 0.768737570771889 0.705882352941177 17.5 17 5 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0504786686611309 0.0862318673526883 0.768737570771889 0.705882352941177 17.5 17 5 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0504786686611309 0.0862318673526883 0.768737570771889 0.705882352941177 17.5 17 5 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.64313004036628e-76 5.84543511860303e-74 0.76844807416142 0.705616526791478 17.5 17 5 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.3674797225782e-27 1.60424935487085e-25 0.762903602050328 0.700525394045534 17.5 17 5 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0386458518940246 0.0688273432355406 0.76233142434879 0.7 17.5 17 5 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.139104048329975 0.20619277163912 0.76233142434879 0.7 17.5 17 5 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.139104048329975 0.20619277163912 0.76233142434879 0.7 17.5 17 5 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.139104048329975 0.20619277163912 0.76233142434879 0.7 17.5 17 5 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.139104048329975 0.20619277163912 0.76233142434879 0.7 17.5 17 5 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.139104048329975 0.20619277163912 0.76233142434879 0.7 17.5 17 5 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.139104048329975 0.20619277163912 0.76233142434879 0.7 17.5 17 5 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000145598757650565 0.000455356114586274 0.76233142434879 0.7 17.5 17 5 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00239098221553442 0.00566117752530031 0.757596446557804 0.695652173913043 17.5 17 5 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0229854383036953 0.0437861830069054 0.753954155949353 0.692307692307692 17.5 17 5 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0229854383036953 0.0437861830069054 0.753954155949353 0.692307692307692 17.5 17 5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.10270305360659 0.160424198992512 0.753954155949353 0.692307692307692 17.5 17 5 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.10270305360659 0.160424198992512 0.753954155949353 0.692307692307692 17.5 17 5 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.10270305360659 0.160424198992512 0.753954155949353 0.692307692307692 17.5 17 5 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.10270305360659 0.160424198992512 0.753954155949353 0.692307692307692 17.5 17 5 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.10270305360659 0.160424198992512 0.753954155949353 0.692307692307692 17.5 17 5 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00118039515609906 0.00301021918840317 0.752431016240364 0.690909090909091 17.5 17 5 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00118039515609906 0.00301021918840317 0.752431016240364 0.690909090909091 17.5 17 5 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 4.37692348410896e-05 0.000149361201867795 0.750230925549603 0.688888888888889 17.5 17 5 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00353571463458129 0.00808894200162247 0.750230925549603 0.688888888888889 17.5 17 5 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00278383697432409 0.00644130083652551 0.748718363199704 0.6875 17.5 17 5 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0769848344673273 0.123924682632361 0.748718363199704 0.6875 17.5 17 5 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0769848344673273 0.123924682632361 0.748718363199704 0.6875 17.5 17 5 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0769848344673273 0.123924682632361 0.748718363199704 0.6875 17.5 17 5 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0769848344673273 0.123924682632361 0.748718363199704 0.6875 17.5 17 5 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000368164893425493 0.00103129654201669 0.746773640178407 0.685714285714286 17.5 17 5 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0583101001013988 0.0960361949586695 0.745135978686787 0.684210526315789 17.5 17 5 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.95818593751022e-07 2.16426337088253e-06 0.735278716842327 0.67515923566879 17.5 17 5 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00664379835002384 0.0142381401386806 0.726029927951228 0.666666666666667 17.5 17 5 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0138924482021756 0.0274568802662442 0.726029927951228 0.666666666666667 17.5 17 5 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0178386524922725 0.0345836546273894 0.726029927951228 0.666666666666667 17.5 17 5 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0296583236813048 0.0532204219400968 0.726029927951228 0.666666666666667 17.5 17 5 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0296583236813048 0.0532204219400968 0.726029927951228 0.666666666666667 17.5 17 5 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0864221562298246 0.138645691448749 0.726029927951228 0.666666666666667 17.5 17 5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0864221562298246 0.138645691448749 0.726029927951228 0.666666666666667 17.5 17 5 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.115058967854017 0.173154931470724 0.726029927951228 0.666666666666667 17.5 17 5 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.155246336568245 0.228218529893195 0.726029927951228 0.666666666666667 17.5 17 5 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.155246336568245 0.228218529893195 0.726029927951228 0.666666666666667 17.5 17 5 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.155246336568245 0.228218529893195 0.726029927951228 0.666666666666667 17.5 17 5 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.155246336568245 0.228218529893195 0.726029927951228 0.666666666666667 17.5 17 5 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.213751033820759 0.301156159531623 0.726029927951228 0.666666666666667 17.5 17 5 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.213751033820759 0.301156159531623 0.726029927951228 0.666666666666667 17.5 17 5 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.213751033820759 0.301156159531623 0.726029927951228 0.666666666666667 17.5 17 5 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.213751033820759 0.301156159531623 0.726029927951228 0.666666666666667 17.5 17 5 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.213751033820759 0.301156159531623 0.726029927951228 0.666666666666667 17.5 17 5 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.213751033820759 0.301156159531623 0.726029927951228 0.666666666666667 17.5 17 5 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.213751033820759 0.301156159531623 0.726029927951228 0.666666666666667 17.5 17 5 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 9.48881817433779e-08 4.48590972162215e-07 0.724187212398053 0.66497461928934 17.5 17 5 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00581444332056725 0.0125743964212267 0.719180589008292 0.660377358490566 17.5 17 5 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.000167984387759019 0.000521925292098438 0.71565807183764 0.657142857142857 17.5 17 5 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0328849044820419 0.0588619107898687 0.714685710326991 0.65625 17.5 17 5 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.042552577221256 0.074480095185544 0.713512170572759 0.655172413793103 17.5 17 5 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0721825975598934 0.116722541281509 0.710246668647941 0.652173913043478 17.5 17 5 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0948294182008084 0.149107471933426 0.707879179752448 0.65 17.5 17 5 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0145645529574497 0.0283133317738401 0.703341492702753 0.645833333333333 17.5 17 5 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000307639642639068 0.000882603248942325 0.702928975698235 0.645454545454546 17.5 17 5 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0602052236438291 0.0990428130001952 0.700100287667256 0.642857142857143 17.5 17 5 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.168090628934702 0.241121940498066 0.700100287667256 0.642857142857143 17.5 17 5 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.168090628934702 0.241121940498066 0.700100287667256 0.642857142857143 17.5 17 5 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.168090628934702 0.241121940498066 0.700100287667256 0.642857142857143 17.5 17 5 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 8.62038924647615e-13 9.65890858089414e-12 0.693028567589809 0.636363636363636 17.5 17 5 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.102338479228053 0.160424198992512 0.693028567589809 0.636363636363636 17.5 17 5 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.228428848963334 0.308767437728586 0.693028567589809 0.636363636363636 17.5 17 5 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0648244696993533 0.106395871259723 0.689728431553667 0.633333333333333 17.5 17 5 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0216791615701088 0.0414643103686355 0.688987584688411 0.63265306122449 17.5 17 5 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.134614252449983 0.201003233196565 0.687817826480111 0.631578947368421 17.5 17 5 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0183007316349201 0.0354312124033896 0.685694931953938 0.62962962962963 17.5 17 5 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0839172325922406 0.134931324269783 0.685694931953938 0.62962962962963 17.5 17 5 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00010130957744356 0.000329893658357405 0.683189652699448 0.627329192546584 17.5 17 5 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000108091628693371 0.000350374459295368 0.681488214579988 0.625766871165644 17.5 17 5 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0691574529175616 0.112852719264095 0.680653057454277 0.625 17.5 17 5 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.178515856831834 0.255818795842598 0.680653057454277 0.625 17.5 17 5 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.317716066588199 0.41138304163331 0.680653057454277 0.625 17.5 17 5 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.317716066588199 0.41138304163331 0.680653057454277 0.625 17.5 17 5 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.317716066588199 0.41138304163331 0.680653057454277 0.625 17.5 17 5 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.029433729424995 0.0529509443385182 0.680653057454277 0.625 17.5 17 5 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.029433729424995 0.0529509443385182 0.680653057454277 0.625 17.5 17 5 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.000142988475795102 0.000452746691678606 0.678972432621056 0.623456790123457 17.5 17 5 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0110369164818166 0.022695855713331 0.678680150041366 0.623188405797101 17.5 17 5 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0373782938804951 0.0666532734234894 0.67762793275448 0.622222222222222 17.5 17 5 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.91896517223767e-06 1.51129740923962e-05 0.674780756566436 0.619607843137255 17.5 17 5 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.142433572973207 0.21090840201964 0.674170647383284 0.619047619047619 17.5 17 5 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00989165324271704 0.0203997428469367 0.673488288428442 0.618421052631579 17.5 17 5 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.115112132938373 0.173154931470724 0.67018147195498 0.615384615384615 17.5 17 5 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.239315589306892 0.321573261174417 0.67018147195498 0.615384615384615 17.5 17 5 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.239315589306892 0.321573261174417 0.67018147195498 0.615384615384615 17.5 17 5 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.239315589306892 0.321573261174417 0.67018147195498 0.615384615384615 17.5 17 5 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0938586223265069 0.147744269436526 0.66747912731 0.612903225806452 17.5 17 5 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0938586223265069 0.147744269436526 0.66747912731 0.612903225806452 17.5 17 5 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0938586223265069 0.147744269436526 0.66747912731 0.612903225806452 17.5 17 5 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0635392586844382 0.104406888115422 0.664051763370026 0.609756097560976 17.5 17 5 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.120563064603422 0.180400884259379 0.661205827241297 0.607142857142857 17.5 17 5 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000918072303017218 0.00243280612140317 0.660453031233053 0.606451612903226 17.5 17 5 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00100261662995751 0.00264698230877466 0.657536538521867 0.60377358490566 17.5 17 5 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00100261662995751 0.00264698230877466 0.657536538521867 0.60377358490566 17.5 17 5 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.194291503823745 0.275924960021147 0.653426935156106 0.6 17.5 17 5 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.194291503823745 0.275924960021147 0.653426935156106 0.6 17.5 17 5 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.194291503823745 0.275924960021147 0.653426935156106 0.6 17.5 17 5 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.325721512056935 0.419838506935705 0.653426935156106 0.6 17.5 17 5 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.325721512056935 0.419838506935705 0.653426935156106 0.6 17.5 17 5 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.325721512056935 0.419838506935705 0.653426935156106 0.6 17.5 17 5 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.325721512056935 0.419838506935705 0.653426935156106 0.6 17.5 17 5 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.325721512056935 0.419838506935705 0.653426935156106 0.6 17.5 17 5 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0573218723160768 0.0946276384057742 0.653426935156106 0.6 17.5 17 5 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.125491726289251 0.187578494232778 0.653426935156106 0.6 17.5 17 5 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.155221552295572 0.228218529893195 0.653426935156106 0.6 17.5 17 5 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.155221552295572 0.228218529893195 0.653426935156106 0.6 17.5 17 5 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.155221552295572 0.228218529893195 0.653426935156106 0.6 17.5 17 5 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.10607617271561 0.165503834479405 0.647540206010555 0.594594594594595 17.5 17 5 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.109556056096366 0.165503834479405 0.642257243956856 0.58974358974359 17.5 17 5 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.109556056096366 0.165503834479405 0.642257243956856 0.58974358974359 17.5 17 5 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0928408921153632 0.146628845150013 0.639222001783147 0.58695652173913 17.5 17 5 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0246681953445868 0.0461344019948411 0.63720711761677 0.585106382978723 17.5 17 5 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.205502077662217 0.291554792136923 0.635276186957325 0.583333333333333 17.5 17 5 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.330884366316459 0.425721928814033 0.635276186957325 0.583333333333333 17.5 17 5 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.330884366316459 0.425721928814033 0.635276186957325 0.583333333333333 17.5 17 5 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0118407230952849 0.0240679720823193 0.634561590571546 0.582677165354331 17.5 17 5 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0692343105534469 0.112852719264095 0.632348646925263 0.580645161290323 17.5 17 5 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0111090077440432 0.0228111371136702 0.63009025890053 0.578571428571429 17.5 17 5 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0113741907171795 0.023322007767358 0.628885078436628 0.577464788732394 17.5 17 5 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0133934183539166 0.0265074190787528 0.627989390235187 0.576642335766423 17.5 17 5 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0447118558949446 0.0780674490043021 0.627802349463709 0.576470588235294 17.5 17 5 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0447118558949446 0.0780674490043021 0.627802349463709 0.576470588235294 17.5 17 5 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00667408603438215 0.0142815404916178 0.626833978492776 0.575581395348837 17.5 17 5 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0219194101676808 0.0418675445216239 0.624861823236713 0.573770491803279 17.5 17 5 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.016469240743395 0.0319723459452266 0.62459927625216 0.573529411764706 17.5 17 5 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.334282203136479 0.428158033360225 0.622311366815339 0.571428571428571 17.5 17 5 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.334282203136479 0.428158033360225 0.622311366815339 0.571428571428571 17.5 17 5 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.334282203136479 0.428158033360225 0.622311366815339 0.571428571428571 17.5 17 5 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.334282203136479 0.428158033360225 0.622311366815339 0.571428571428571 17.5 17 5 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.334282203136479 0.428158033360225 0.622311366815339 0.571428571428571 17.5 17 5 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0485390625780792 0.0846459387850572 0.620638486797018 0.56989247311828 17.5 17 5 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0205355822074516 0.0394360775724745 0.6200401574474 0.569343065693431 17.5 17 5 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0575263330789472 0.0948551239528874 0.618775506776615 0.568181818181818 17.5 17 5 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.179257647813627 0.256623373077254 0.618106560282803 0.567567567567568 17.5 17 5 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.217006116352312 0.305439865053749 0.617125438758544 0.566666666666667 17.5 17 5 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.266780112244086 0.357802167505498 0.615547112828216 0.565217391304348 17.5 17 5 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.111585736791512 0.168206041794832 0.612587751708849 0.5625 17.5 17 5 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.336509602486452 0.43062334922502 0.612587751708849 0.5625 17.5 17 5 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.269495473583401 0.360763931240997 0.609865139479032 0.56 17.5 17 5 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.269495473583401 0.360763931240997 0.609865139479032 0.56 17.5 17 5 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00698773364819719 0.0148632959362999 0.607940722802535 0.558232931726908 17.5 17 5 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.135005962885721 0.201376818853649 0.607008628287093 0.557377049180328 17.5 17 5 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.271703317072327 0.363377650558196 0.605024939959357 0.555555555555556 17.5 17 5 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.4476723575475 0.562754209178527 0.605024939959357 0.555555555555556 17.5 17 5 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.4476723575475 0.562754209178527 0.605024939959357 0.555555555555556 17.5 17 5 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.4476723575475 0.562754209178527 0.605024939959357 0.555555555555556 17.5 17 5 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.4476723575475 0.562754209178527 0.605024939959357 0.555555555555556 17.5 17 5 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.2749454042168 0.367023743152445 0.597218166540527 0.548387096774194 17.5 17 5 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.107693198630074 0.165503834479405 0.59610878294943 0.547368421052632 17.5 17 5 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.108459958190864 0.165503834479405 0.595045147135285 0.54639175257732 17.5 17 5 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0390364051681596 0.0694360056928639 0.594559643700601 0.545945945945946 17.5 17 5 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.276107402239919 0.367540536377366 0.594024486505551 0.545454545454545 17.5 17 5 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.276107402239919 0.367540536377366 0.594024486505551 0.545454545454545 17.5 17 5 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.276107402239919 0.367540536377366 0.594024486505551 0.545454545454545 17.5 17 5 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.442472707769256 0.558685592862157 0.594024486505551 0.545454545454545 17.5 17 5 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.442472707769256 0.558685592862157 0.594024486505551 0.545454545454545 17.5 17 5 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.442472707769256 0.558685592862157 0.594024486505551 0.545454545454545 17.5 17 5 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.437714606160953 0.554152922212666 0.586408787960608 0.538461538461538 17.5 17 5 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.437714606160953 0.554152922212666 0.586408787960608 0.538461538461538 17.5 17 5 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.437714606160953 0.554152922212666 0.586408787960608 0.538461538461538 17.5 17 5 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.278661045430542 0.368485761813237 0.584365551765623 0.536585365853659 17.5 17 5 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.338609653817635 0.432532798368487 0.58341690638938 0.535714285714286 17.5 17 5 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.278913211429405 0.368485761813237 0.582512384053893 0.534883720930233 17.5 17 5 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.338056120844634 0.432213710657605 0.580823942360983 0.533333333333333 17.5 17 5 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.433304011800193 0.550037117566169 0.580823942360983 0.533333333333333 17.5 17 5 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.429176233226769 0.545283732037226 0.576553178078917 0.529411764705882 17.5 17 5 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.429176233226769 0.545283732037226 0.576553178078917 0.529411764705882 17.5 17 5 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.429176233226769 0.545283732037226 0.576553178078917 0.529411764705882 17.5 17 5 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.425284521027998 0.541790396976581 0.573181522066759 0.526315789473684 17.5 17 5 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.272345684262018 0.363894749957607 0.565200513531653 0.518987341772152 17.5 17 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.408374155998606 0.520713641564531 0.563299082031126 0.517241379310345 17.5 17 5 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.405374218580991 0.51735202963296 0.56208768615579 0.516129032258065 17.5 17 5 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.265489894909559 0.356407660807832 0.551162963597122 0.50609756097561 17.5 17 5 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.511820115871174 0.611006732285806 0.544522445963421 0.5 17.5 17 5 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.511820115871174 0.611006732285806 0.544522445963421 0.5 17.5 17 5 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.569623203038064 0.674354257839571 0.544522445963421 0.5 17.5 17 5 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.569623203038064 0.674354257839571 0.544522445963421 0.5 17.5 17 5 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.569623203038064 0.674354257839571 0.544522445963421 0.5 17.5 17 5 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.484356191008771 0.57919231916427 0.544522445963421 0.5 17.5 17 5 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.520429617605418 0.620763911024735 0.544522445963421 0.5 17.5 17 5 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.541147009185428 0.644395141481894 0.544522445963421 0.5 17.5 17 5 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.554061049222053 0.658120929084291 0.544522445963421 0.5 17.5 17 5 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.554061049222053 0.658120929084291 0.544522445963421 0.5 17.5 17 5 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.554061049222053 0.658120929084291 0.544522445963421 0.5 17.5 17 5 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.443495457475167 0.559480528357414 0.534050860464125 0.490384615384615 17.5 17 5 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.563719159661075 0.669034498913853 0.524354947964776 0.481481481481481 17.5 17 5 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.527998340614793 0.629264354015788 0.521033242412058 0.47843137254902 17.5 17 5 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.593794049565985 0.697744783263747 0.513700420720209 0.471698113207547 17.5 17 5 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.920083339097328 0.98868602174024 0.505210581571916 0.46390243902439 17.5 17 5 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.645119886912972 0.75308088521506 0.502636103966235 0.461538461538462 17.5 17 5 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.668673977807034 0.771088387698063 0.495020405421292 0.454545454545455 17.5 17 5 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.675581949095404 0.778423573735028 0.495020405421292 0.454545454545455 17.5 17 5 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.695247858399691 0.800435034387347 0.488192537760309 0.448275862068966 17.5 17 5 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.699308964540209 0.804459706176813 0.484019951967486 0.444444444444444 17.5 17 5 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.755269411054751 0.850275610704834 0.48203626363975 0.442622950819672 17.5 17 5 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.728155425645935 0.822449723173817 0.480460981732431 0.441176470588235 17.5 17 5 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.720495891935769 0.822449723173817 0.479179752447811 0.44 17.5 17 5 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.738266243841169 0.831791658737912 0.466733525111504 0.428571428571429 17.5 17 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.776929643313461 0.873969077023759 0.460749761969049 0.423076923076923 17.5 17 5 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.799523137052353 0.888844862519921 0.456696245001579 0.419354838709677 17.5 17 5 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.878954936960255 0.954044908691413 0.440252190353405 0.404255319148936 17.5 17 5 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.898337097579104 0.971378183780444 0.439439166917849 0.403508771929825 17.5 17 5 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.806770651803609 0.896201902823213 0.435617956770737 0.4 17.5 17 5 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.864907231879301 0.940950298902328 0.435617956770737 0.4 17.5 17 5 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.923926242776628 0.98868602174024 0.432160671399541 0.396825396825397 17.5 17 5 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.902751769198435 0.975410605595576 0.431080269721042 0.395833333333333 17.5 17 5 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.939138390478866 1 0.429482492590868 0.394366197183099 17.5 17 5 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.963893637384285 1 0.429017684698453 0.393939393939394 17.5 17 5 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.830255104372229 0.917989909496256 0.418863419971863 0.384615384615385 17.5 17 5 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999972560535061 1 0.412602059570221 0.378865979381443 17.5 17 5 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999717432910675 1 0.412281280515162 0.378571428571429 17.5 17 5 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.860335365381602 0.936692597504223 0.408391834472566 0.375 17.5 17 5 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.860335365381602 0.936692597504223 0.408391834472566 0.375 17.5 17 5 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.860335365381602 0.936692597504223 0.408391834472566 0.375 17.5 17 5 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.921923675043709 0.98868602174024 0.399316460373176 0.366666666666667 17.5 17 5 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999294610988869 1 0.398145444360351 0.365591397849462 17.5 17 5 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.881360026889485 0.955926309652238 0.388944604259587 0.357142857142857 17.5 17 5 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.941881950107934 1 0.386435284232105 0.354838709677419 17.5 17 5 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.941881950107934 1 0.386435284232105 0.354838709677419 17.5 17 5 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.99997364626081 1 0.376398004122181 0.345622119815668 17.5 17 5 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.997514248974707 1 0.358419837849341 0.329113924050633 17.5 17 5 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.952582296291859 1 0.343908913240056 0.315789473684211 17.5 17 5 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.986151832889733 1 0.343908913240056 0.315789473684211 17.5 17 5 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.984010019112723 1 0.342271251748436 0.314285714285714 17.5 17 5 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99999976670125 1 0.32176326352384 0.295454545454545 17.5 17 5 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.978532565945121 1 0.311155683407669 0.285714285714286 17.5 17 5 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.998145231382762 1 0.311155683407669 0.285714285714286 17.5 17 5 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.993051130979552 1 0.306293875854425 0.28125 17.5 17 5 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.985810926071225 1 0.297012243252775 0.272727272727273 17.5 17 5 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.985810926071225 1 0.297012243252775 0.272727272727273 17.5 17 5 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.278890589452298 0.256087321578505 17.5 17 5 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.990113586066574 1 0.272261222981711 0.25 17.5 17 5 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999696790818 1 0.272261222981711 0.25 17.5 17 5 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999557555448 1 0.25411047478293 0.233333333333333 17.5 17 5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999900728776779 1 0.249572787733235 0.229166666666667 17.5 17 5 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.235336102324155 0.216094032549729 17.5 17 5 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.999768297715617 1 0.210782882308421 0.193548387096774 17.5 17 5 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.999955682010706 1 0.175652401923684 0.161290322580645 17.5 17 5 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999999623040193 1 0.16219817539336 0.148936170212766 17.5 17 5 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0193217642116053 0.017741935483871 17.5 17 5 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 6.54351293563789e-05 0.000313515788128374 2.9593837535014 1 17.4 17 4 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 1.6516500351445e-05 9.21685490200243e-05 2.9593837535014 1 17.4 17 4 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00102679341195762 0.00345140199510874 2.9593837535014 1 17.4 17 4 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.00102679341195762 0.00345140199510874 2.9593837535014 1 17.4 17 4 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.00102679341195762 0.00345140199510874 2.9593837535014 1 17.4 17 4 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.000115299937764168 0.000520862893455273 2.63056333644569 0.888888888888889 17.4 17 4 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00142191865887313 0.0046090894113359 2.53661464585834 0.857142857142857 17.4 17 4 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00142191865887313 0.0046090894113359 2.53661464585834 0.857142857142857 17.4 17 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 4.12603856555197e-05 0.000211199743841024 2.46615312791783 0.833333333333333 17.4 17 4 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 4.12603856555197e-05 0.000211199743841024 2.46615312791783 0.833333333333333 17.4 17 4 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00486466801816614 0.013085865009169 2.46615312791783 0.833333333333333 17.4 17 4 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00486466801816614 0.013085865009169 2.46615312791783 0.833333333333333 17.4 17 4 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00486466801816614 0.013085865009169 2.46615312791783 0.833333333333333 17.4 17 4 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00486466801816614 0.013085865009169 2.46615312791783 0.833333333333333 17.4 17 4 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00486466801816614 0.013085865009169 2.46615312791783 0.833333333333333 17.4 17 4 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.00486466801816614 0.013085865009169 2.46615312791783 0.833333333333333 17.4 17 4 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00486466801816614 0.013085865009169 2.46615312791783 0.833333333333333 17.4 17 4 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000137068800626286 0.000598309519298173 2.42131398013751 0.818181818181818 17.4 17 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 4.25540628791504e-06 2.67939962287748e-05 2.40449929971989 0.8125 17.4 17 4 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00044762909153678 0.00168512221496518 2.36750700280112 0.8 17.4 17 4 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00044762909153678 0.00168512221496518 2.36750700280112 0.8 17.4 17 4 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 4.39760446698611e-05 0.000221123362421245 2.32523009203681 0.785714285714286 17.4 17 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 4.39760446698611e-05 0.000221123362421245 2.32523009203681 0.785714285714286 17.4 17 4 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 4.39760446698611e-05 0.000221123362421245 2.32523009203681 0.785714285714286 17.4 17 4 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00143184511358454 0.00462021677240543 2.30174291938998 0.777777777777778 17.4 17 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00143184511358454 0.00462021677240543 2.30174291938998 0.777777777777778 17.4 17 4 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000137984167648299 0.000598632532205884 2.27644904115492 0.769230769230769 17.4 17 4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000137984167648299 0.000598632532205884 2.27644904115492 0.769230769230769 17.4 17 4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.38691021718154e-05 8.02265544328999e-05 2.26305816444225 0.764705882352941 17.4 17 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 4.23551257866637e-05 0.00021580111758869 2.21953781512605 0.75 17.4 17 4 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000424494045538582 0.00162380383548764 2.21953781512605 0.75 17.4 17 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000424494045538582 0.00162380383548764 2.21953781512605 0.75 17.4 17 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000424494045538582 0.00162380383548764 2.21953781512605 0.75 17.4 17 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000424494045538582 0.00162380383548764 2.21953781512605 0.75 17.4 17 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000424494045538582 0.00162380383548764 2.21953781512605 0.75 17.4 17 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000424494045538582 0.00162380383548764 2.21953781512605 0.75 17.4 17 4 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.000424494045538582 0.00162380383548764 2.21953781512605 0.75 17.4 17 4 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.00446407803831976 0.0122870078308105 2.21953781512605 0.75 17.4 17 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00446407803831976 0.0122870078308105 2.21953781512605 0.75 17.4 17 4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00446407803831976 0.0122870078308105 2.21953781512605 0.75 17.4 17 4 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00446407803831976 0.0122870078308105 2.21953781512605 0.75 17.4 17 4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00446407803831976 0.0122870078308105 2.21953781512605 0.75 17.4 17 4 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00446407803831976 0.0122870078308105 2.21953781512605 0.75 17.4 17 4 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00446407803831976 0.0122870078308105 2.21953781512605 0.75 17.4 17 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 1.30074673121967e-05 7.58591228903929e-05 2.18059855521156 0.736842105263158 17.4 17 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.81481996092446e-11 4.37709966846696e-10 2.17021475256769 0.733333333333333 17.4 17 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 4.23173460839041e-07 3.56317061996424e-06 2.16262658909718 0.730769230769231 17.4 17 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 5.30330375521279e-11 1.0510692599169e-09 2.15227909345556 0.727272727272727 17.4 17 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.4685709486496e-09 5.52937083472033e-08 2.13733271086212 0.722222222222222 17.4 17 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000373004475094395 0.00151220902581004 2.11384553821529 0.714285714285714 17.4 17 4 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0134715414163987 0.030525483177604 2.11384553821529 0.714285714285714 17.4 17 4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0134715414163987 0.030525483177604 2.11384553821529 0.714285714285714 17.4 17 4 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0134715414163987 0.030525483177604 2.11384553821529 0.714285714285714 17.4 17 4 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0134715414163987 0.030525483177604 2.11384553821529 0.714285714285714 17.4 17 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.16298987723514e-05 6.83857270787439e-05 2.11384553821529 0.714285714285714 17.4 17 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.16298987723514e-05 6.83857270787439e-05 2.11384553821529 0.714285714285714 17.4 17 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 3.54951224214934e-06 2.29588905480842e-05 2.09623015873016 0.708333333333333 17.4 17 4 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0001107215824623 0.000501773286126919 2.08897676717746 0.705882352941177 17.4 17 4 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0001107215824623 0.000501773286126919 2.08897676717746 0.705882352941177 17.4 17 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.54922717933466e-09 4.43030725981862e-08 2.07156862745098 0.7 17.4 17 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 3.32236178454896e-05 0.000173176586791691 2.07156862745098 0.7 17.4 17 4 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00372834916502929 0.0106534957064994 2.07156862745098 0.7 17.4 17 4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00372834916502929 0.0106534957064994 2.07156862745098 0.7 17.4 17 4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00372834916502929 0.0106534957064994 2.07156862745098 0.7 17.4 17 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.03308541746796e-07 9.41913688259612e-07 2.06260079789492 0.696969696969697 17.4 17 4 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00106914127079172 0.00357538747077918 2.04880413703943 0.692307692307692 17.4 17 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000313264301076774 0.00128836734228974 2.03457633053221 0.6875 17.4 17 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000313264301076774 0.00128836734228974 2.03457633053221 0.6875 17.4 17 4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 9.31276992036401e-05 0.00043592340778546 2.02484151555359 0.684210526315789 17.4 17 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 2.79747065726898e-05 0.00014743706464051 2.01776165011459 0.681818181818182 17.4 17 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 8.77002757876921e-14 2.77327760990857e-12 2.01581212195023 0.681159420289855 17.4 17 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 2.31258685587796e-08 2.45582917605548e-07 1.99758403361345 0.675 17.4 17 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 2.305163216683e-05 0.00012567997154559 1.97292250233427 0.666666666666667 17.4 17 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 2.305163216683e-05 0.00012567997154559 1.97292250233427 0.666666666666667 17.4 17 4 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00297838151081713 0.00884809371585132 1.97292250233427 0.666666666666667 17.4 17 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.13827397483941e-06 1.42185227392359e-05 1.97292250233427 0.666666666666667 17.4 17 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 7.64110559917662e-05 0.000362443108920945 1.97292250233427 0.666666666666667 17.4 17 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000255547561041594 0.00106018711184312 1.97292250233427 0.666666666666667 17.4 17 4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000255547561041594 0.00106018711184312 1.97292250233427 0.666666666666667 17.4 17 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000255547561041594 0.00106018711184312 1.97292250233427 0.666666666666667 17.4 17 4 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.000864984939153538 0.00300213065467191 1.97292250233427 0.666666666666667 17.4 17 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000864984939153538 0.00300213065467191 1.97292250233427 0.666666666666667 17.4 17 4 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000864984939153538 0.00300213065467191 1.97292250233427 0.666666666666667 17.4 17 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000864984939153538 0.00300213065467191 1.97292250233427 0.666666666666667 17.4 17 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000864984939153538 0.00300213065467191 1.97292250233427 0.666666666666667 17.4 17 4 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0105285438877902 0.0248872391234643 1.97292250233427 0.666666666666667 17.4 17 4 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0105285438877902 0.0248872391234643 1.97292250233427 0.666666666666667 17.4 17 4 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0105285438877902 0.0248872391234643 1.97292250233427 0.666666666666667 17.4 17 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 4.79993692311318e-10 6.83031024159005e-09 1.95431002589715 0.660377358490566 17.4 17 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.94892557402575e-09 6.07096645848159e-08 1.95193396507539 0.659574468085106 17.4 17 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 9.16552319338515e-19 7.24585528010393e-17 1.94552080091296 0.657407407407407 17.4 17 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 5.37871683214542e-07 3.96575857623986e-06 1.94473789515806 0.657142857142857 17.4 17 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.7481859422938e-06 1.1735872919593e-05 1.94209558823529 0.65625 17.4 17 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 6.13198484972577e-22 7.2715120342998e-20 1.93498168498169 0.653846153846154 17.4 17 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.86882385605028e-05 0.00010347612245757 1.93498168498168 0.653846153846154 17.4 17 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.86882385605028e-05 0.00010347612245757 1.93498168498168 0.653846153846154 17.4 17 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000204378136011635 0.000873363626259928 1.92359943977591 0.65 17.4 17 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.41341313966788e-06 9.81115559876776e-06 1.91489536991267 0.647058823529412 17.4 17 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000684592618536641 0.00247252613243056 1.91489536991267 0.647058823529412 17.4 17 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.000684592618536641 0.00247252613243056 1.91489536991267 0.647058823529412 17.4 17 4 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000684592618536641 0.00247252613243056 1.91489536991267 0.647058823529412 17.4 17 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 8.21876466069145e-11 1.49939770668768e-09 1.90927984096865 0.645161290322581 17.4 17 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 1.49615993383906e-05 8.41516041839125e-05 1.90246098439376 0.642857142857143 17.4 17 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00232218750304691 0.0070911433837677 1.90246098439376 0.642857142857143 17.4 17 4 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00232218750304691 0.0070911433837677 1.90246098439376 0.642857142857143 17.4 17 4 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00232218750304691 0.0070911433837677 1.90246098439376 0.642857142857143 17.4 17 4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00232218750304691 0.0070911433837677 1.90246098439376 0.642857142857143 17.4 17 4 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00232218750304691 0.0070911433837677 1.90246098439376 0.642857142857143 17.4 17 4 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00232218750304691 0.0070911433837677 1.90246098439376 0.642857142857143 17.4 17 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00232218750304691 0.0070911433837677 1.90246098439376 0.642857142857143 17.4 17 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 4.89757087765083e-05 0.000244534854698145 1.8940056022409 0.64 17.4 17 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00802032793605889 0.0194759840495082 1.88324420677362 0.636363636363636 17.4 17 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 9.00204037312172e-07 6.4371374125388e-06 1.86908447589562 0.631578947368421 17.4 17 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 6.96363693746998e-08 6.51924694869722e-07 1.86569845329436 0.630434782608696 17.4 17 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.0849032110624e-11 2.66175391265826e-10 1.86481715974061 0.63013698630137 17.4 17 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 3.85551321160791e-05 0.000199328837551631 1.86331569664903 0.62962962962963 17.4 17 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.1991198030925e-13 6.80292930391442e-12 1.85821770568693 0.627906976744186 17.4 17 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.08425181790677e-10 1.81516510221333e-09 1.85513608428446 0.626865671641791 17.4 17 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.13693425271876e-15 7.35389746190363e-14 1.84961484593838 0.625 17.4 17 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00178451933594815 0.0056180774669341 1.84961484593838 0.625 17.4 17 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00178451933594815 0.0056180774669341 1.84961484593838 0.625 17.4 17 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00178451933594815 0.0056180774669341 1.84961484593838 0.625 17.4 17 4 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00178451933594815 0.0056180774669341 1.84961484593838 0.625 17.4 17 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0284839803798636 0.0579867011166608 1.84961484593838 0.625 17.4 17 4 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0284839803798636 0.0579867011166608 1.84961484593838 0.625 17.4 17 4 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0284839803798636 0.0579867011166608 1.84961484593838 0.625 17.4 17 4 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0284839803798636 0.0579867011166608 1.84961484593838 0.625 17.4 17 4 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0284839803798636 0.0579867011166608 1.84961484593838 0.625 17.4 17 4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0284839803798636 0.0579867011166608 1.84961484593838 0.625 17.4 17 4 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.0284839803798636 0.0579867011166608 1.84961484593838 0.625 17.4 17 4 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0284839803798636 0.0579867011166608 1.84961484593838 0.625 17.4 17 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.75515517741117e-07 1.53226123770313e-06 1.84139433551198 0.622222222222222 17.4 17 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.51787062999547e-14 1.56435309577611e-12 1.83793306796403 0.621052631578947 17.4 17 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.42257698123021e-09 4.31002393300052e-08 1.83685888148363 0.620689655172414 17.4 17 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.42257698123021e-09 4.31002393300052e-08 1.83685888148363 0.620689655172414 17.4 17 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000412324641043918 0.00162380383548764 1.83199946645325 0.619047619047619 17.4 17 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000412324641043918 0.00162380383548764 1.83199946645325 0.619047619047619 17.4 17 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 7.28849480667183e-06 4.39471530080255e-05 1.82785467128028 0.617647058823529 17.4 17 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 5.37147619757917e-11 1.0510692599169e-09 1.82427765626799 0.616438356164384 17.4 17 4 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0060331658948578 0.0156094455788775 1.82115923292394 0.615384615384615 17.4 17 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0060331658948578 0.0156094455788775 1.82115923292394 0.615384615384615 17.4 17 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0060331658948578 0.0156094455788775 1.82115923292394 0.615384615384615 17.4 17 4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0060331658948578 0.0156094455788775 1.82115923292394 0.615384615384615 17.4 17 4 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0060331658948578 0.0156094455788775 1.82115923292394 0.615384615384615 17.4 17 4 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0060331658948578 0.0156094455788775 1.82115923292394 0.615384615384615 17.4 17 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0060331658948578 0.0156094455788775 1.82115923292394 0.615384615384615 17.4 17 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.36838526557999e-28 2.4340152911504e-26 1.81790716286515 0.614285714285714 17.4 17 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.22483981345492e-11 8.84109860962699e-10 1.81508870214753 0.613333333333333 17.4 17 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.22483981345492e-11 8.84109860962699e-10 1.81508870214753 0.613333333333333 17.4 17 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.22483981345492e-11 8.84109860962699e-10 1.81508870214753 0.613333333333333 17.4 17 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.22483981345492e-11 8.84109860962699e-10 1.81508870214753 0.613333333333333 17.4 17 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.22483981345492e-11 8.84109860962699e-10 1.81508870214753 0.613333333333333 17.4 17 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.28388127180702e-10 7.44451787107069e-09 1.81096617751578 0.611940298507463 17.4 17 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 5.66519787896327e-06 3.47481749213997e-05 1.80851229380641 0.611111111111111 17.4 17 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00135880628031458 0.00445525653660747 1.80851229380641 0.611111111111111 17.4 17 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00135880628031458 0.00445525653660747 1.80851229380641 0.611111111111111 17.4 17 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00135880628031458 0.00445525653660747 1.80851229380641 0.611111111111111 17.4 17 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 6.64105400114628e-09 7.87518320302596e-08 1.80572568010255 0.610169491525424 17.4 17 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 6.64105400114628e-09 7.87518320302596e-08 1.80572568010255 0.610169491525424 17.4 17 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.38411950076452e-06 9.65491200778385e-06 1.80450228872037 0.609756097560976 17.4 17 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.38411950076452e-06 9.65491200778385e-06 1.80450228872037 0.609756097560976 17.4 17 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.09026466033849e-12 5.61216341822956e-11 1.80284297627097 0.609195402298851 17.4 17 4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00031609485089723 0.0012897217336993 1.80136402387042 0.608695652173913 17.4 17 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00031609485089723 0.0012897217336993 1.80136402387042 0.608695652173913 17.4 17 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 8.40241846413883e-08 7.76405290549971e-07 1.79884110506948 0.607843137254902 17.4 17 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.22762405645959e-10 4.83299284359407e-09 1.79230283662761 0.605633802816901 17.4 17 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 4.38410724819389e-06 2.74827516043167e-05 1.79120595606664 0.605263157894737 17.4 17 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 2.64041017270781e-07 2.26343594925495e-06 1.78796101774043 0.604166666666667 17.4 17 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.64041017270781e-07 2.26343594925495e-06 1.78796101774043 0.604166666666667 17.4 17 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 5.13761025444217e-15 3.17861712698748e-13 1.7862946980594 0.603603603603604 17.4 17 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.96360801885426e-12 9.89511265057826e-11 1.78235612426789 0.602272727272727 17.4 17 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 5.74899960614645e-05 0.000282097463432634 1.77563025210084 0.6 17.4 17 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 5.74899960614645e-05 0.000282097463432634 1.77563025210084 0.6 17.4 17 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.74899960614645e-05 0.000282097463432634 1.77563025210084 0.6 17.4 17 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000241042109403633 0.00100883212259226 1.77563025210084 0.6 17.4 17 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.000241042109403633 0.00100883212259226 1.77563025210084 0.6 17.4 17 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000241042109403633 0.00100883212259226 1.77563025210084 0.6 17.4 17 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000241042109403633 0.00100883212259226 1.77563025210084 0.6 17.4 17 4 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00450799134888696 0.0123362917105118 1.77563025210084 0.6 17.4 17 4 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00450799134888696 0.0123362917105118 1.77563025210084 0.6 17.4 17 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00450799134888696 0.0123362917105118 1.77563025210084 0.6 17.4 17 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 7.75460972220928e-13 2.20696192694076e-11 1.77563025210084 0.6 17.4 17 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 7.75460972220928e-13 2.20696192694076e-11 1.77563025210084 0.6 17.4 17 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.89394300803427e-11 9.94868700061823e-10 1.77563025210084 0.6 17.4 17 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0010283868207492 0.00345140199510874 1.77563025210084 0.6 17.4 17 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0010283868207492 0.00345140199510874 1.77563025210084 0.6 17.4 17 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0010283868207492 0.00345140199510874 1.77563025210084 0.6 17.4 17 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0010283868207492 0.00345140199510874 1.77563025210084 0.6 17.4 17 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0010283868207492 0.00345140199510874 1.77563025210084 0.6 17.4 17 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0010283868207492 0.00345140199510874 1.77563025210084 0.6 17.4 17 4 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0207288359719316 0.0438293218247528 1.77563025210084 0.6 17.4 17 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.26417536889056e-27 1.99880172214585e-25 1.76501362876989 0.596412556053812 17.4 17 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.57648506043634e-07 1.39337778944156e-06 1.76424800689507 0.596153846153846 17.4 17 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.17295730466739e-10 1.89672527788829e-09 1.76064603056412 0.594936708860759 17.4 17 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.17295730466739e-10 1.89672527788829e-09 1.76064603056412 0.594936708860759 17.4 17 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.17295730466739e-10 1.89672527788829e-09 1.76064603056412 0.594936708860759 17.4 17 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.06368589176112e-05 6.31221294598843e-05 1.75963358316299 0.594594594594595 17.4 17 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.06368589176112e-05 6.31221294598843e-05 1.75963358316299 0.594594594594595 17.4 17 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.06368589176112e-05 6.31221294598843e-05 1.75963358316299 0.594594594594595 17.4 17 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 9.06612722289876e-11 1.55434928170903e-09 1.75370889096379 0.592592592592593 17.4 17 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 9.06612722289876e-11 1.55434928170903e-09 1.75370889096379 0.592592592592593 17.4 17 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.21364391508837e-07 1.09304765263972e-06 1.75370889096379 0.592592592592593 17.4 17 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000183080066949081 0.000787078354285627 1.75370889096379 0.592592592592593 17.4 17 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000775096825087693 0.00273688035260493 1.74872676343265 0.590909090909091 17.4 17 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000775096825087693 0.00273688035260493 1.74872676343265 0.590909090909091 17.4 17 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000775096825087693 0.00273688035260493 1.74872676343265 0.590909090909091 17.4 17 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.39199268966503e-11 1.0510692599169e-09 1.74081397264788 0.588235294117647 17.4 17 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00335584321796458 0.00974564265135429 1.74081397264788 0.588235294117647 17.4 17 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00335584321796458 0.00974564265135429 1.74081397264788 0.588235294117647 17.4 17 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00335584321796458 0.00974564265135429 1.74081397264788 0.588235294117647 17.4 17 4 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00335584321796458 0.00974564265135429 1.74081397264788 0.588235294117647 17.4 17 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00335584321796458 0.00974564265135429 1.74081397264788 0.588235294117647 17.4 17 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00335584321796458 0.00974564265135429 1.74081397264788 0.588235294117647 17.4 17 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00335584321796458 0.00974564265135429 1.74081397264788 0.588235294117647 17.4 17 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.52315938151968e-06 1.04708009657126e-05 1.73702959444647 0.58695652173913 17.4 17 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.52315938151968e-06 1.04708009657126e-05 1.73702959444647 0.58695652173913 17.4 17 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.47299633499578e-08 5.19204918979933e-07 1.72630718954248 0.583333333333333 17.4 17 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.47299633499578e-08 5.19204918979933e-07 1.72630718954248 0.583333333333333 17.4 17 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.47299633499578e-08 5.19204918979933e-07 1.72630718954248 0.583333333333333 17.4 17 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.47299633499578e-08 5.19204918979933e-07 1.72630718954248 0.583333333333333 17.4 17 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.47299633499578e-08 5.19204918979933e-07 1.72630718954248 0.583333333333333 17.4 17 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.47299633499578e-08 5.19204918979933e-07 1.72630718954248 0.583333333333333 17.4 17 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.47299633499578e-08 5.19204918979933e-07 1.72630718954248 0.583333333333333 17.4 17 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000582504465515049 0.00213085823760389 1.72630718954248 0.583333333333333 17.4 17 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000582504465515049 0.00213085823760389 1.72630718954248 0.583333333333333 17.4 17 4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0150790529313973 0.0338980921348789 1.72630718954248 0.583333333333333 17.4 17 4 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0150790529313973 0.0338980921348789 1.72630718954248 0.583333333333333 17.4 17 4 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0150790529313973 0.0338980921348789 1.72630718954248 0.583333333333333 17.4 17 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0150790529313973 0.0338980921348789 1.72630718954248 0.583333333333333 17.4 17 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.0458577574073e-08 1.18115522919888e-07 1.72262636397843 0.582089552238806 17.4 17 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.0458577574073e-08 1.18115522919888e-07 1.72262636397843 0.582089552238806 17.4 17 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 8.77647822419355e-15 4.80343404347209e-13 1.71835185687178 0.580645161290323 17.4 17 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 8.77647822419355e-15 4.80343404347209e-13 1.71835185687178 0.580645161290323 17.4 17 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 8.77647822419355e-15 4.80343404347209e-13 1.71835185687178 0.580645161290323 17.4 17 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000104732229670219 0.00048075471877652 1.71835185687178 0.580645161290323 17.4 17 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 8.85896786391547e-07 6.39406075484479e-06 1.71644257703081 0.58 17.4 17 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 7.99806342136594e-09 9.25304410455589e-08 1.71558478463849 0.579710144927536 17.4 17 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00249294020212546 0.00756386760687532 1.71332743623765 0.578947368421053 17.4 17 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00249294020212546 0.00756386760687532 1.71332743623765 0.578947368421053 17.4 17 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000436869084332973 0.00165336358246229 1.70733678086619 0.576923076923077 17.4 17 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000436869084332973 0.00165336358246229 1.70733678086619 0.576923076923077 17.4 17 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000436869084332973 0.00165336358246229 1.70733678086619 0.576923076923077 17.4 17 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.25824354079379e-10 3.45535543930061e-09 1.70599769319493 0.576470588235294 17.4 17 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 5.89176941857491e-16 3.99237518220576e-14 1.70324244805836 0.575539568345324 17.4 17 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.4554609466525e-05 8.28448370834604e-05 1.70164565826331 0.575 17.4 17 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.4554609466525e-05 8.28448370834604e-05 1.70164565826331 0.575 17.4 17 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000327163003426939 0.0013301512967901 1.69107643057223 0.571428571428571 17.4 17 4 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.010981137083939 0.0257432587651486 1.69107643057223 0.571428571428571 17.4 17 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.010981137083939 0.0257432587651486 1.69107643057223 0.571428571428571 17.4 17 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 7.3868020977513e-08 6.87020874843144e-07 1.69107643057223 0.571428571428571 17.4 17 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.05868717011273e-06 1.37535767280301e-05 1.69107643057223 0.571428571428571 17.4 17 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 5.94659844236255e-05 0.00028979484874938 1.69107643057223 0.571428571428571 17.4 17 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 7.64379442734931e-11 1.41261291819715e-09 1.68653052618897 0.56989247311828 17.4 17 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.55788105677449e-06 1.05564987799529e-05 1.68278684022629 0.568627450980392 17.4 17 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.55788105677449e-06 1.05564987799529e-05 1.68278684022629 0.568627450980392 17.4 17 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.55788105677449e-06 1.05564987799529e-05 1.68278684022629 0.568627450980392 17.4 17 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.22518880142349e-08 3.3893412582991e-07 1.67269516502253 0.565217391304348 17.4 17 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 6.26004828526786e-06 3.82319687121724e-05 1.67269516502253 0.565217391304348 17.4 17 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00137179939153531 0.00446698062735638 1.67269516502253 0.565217391304348 17.4 17 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00137179939153531 0.00446698062735638 1.67269516502253 0.565217391304348 17.4 17 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00137179939153531 0.00446698062735638 1.67269516502253 0.565217391304348 17.4 17 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 9.02383117932536e-10 1.2229439779219e-08 1.67118141374197 0.564705882352941 17.4 17 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 9.02383117932536e-10 1.2229439779219e-08 1.67118141374197 0.564705882352941 17.4 17 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 9.02383117932536e-10 1.2229439779219e-08 1.67118141374197 0.564705882352941 17.4 17 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 8.89686598355073e-07 6.39406075484479e-06 1.66801629742806 0.563636363636364 17.4 17 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00800959822266545 0.0194759840495082 1.66465336134454 0.5625 17.4 17 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.52322296322877e-05 0.000133975607338602 1.66014210562274 0.560975609756098 17.4 17 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.52322296322877e-05 0.000133975607338602 1.66014210562274 0.560975609756098 17.4 17 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.52322296322877e-05 0.000133975607338602 1.66014210562274 0.560975609756098 17.4 17 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 2.52322296322877e-05 0.000133975607338602 1.66014210562274 0.560975609756098 17.4 17 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.52322296322877e-05 0.000133975607338602 1.66014210562274 0.560975609756098 17.4 17 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00101709291874776 0.00345140199510874 1.65725490196078 0.56 17.4 17 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.39903893124759e-08 1.55046863721562e-07 1.65725490196078 0.56 17.4 17 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00013668338245286 0.000598309519298173 1.65377327401549 0.558823529411765 17.4 17 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.89336591753377e-05 0.000104428670567851 1.65174907172171 0.558139534883721 17.4 17 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.67230786689256e-06 1.75239359197609e-05 1.65042555483732 0.557692307692308 17.4 17 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 2.67230786689256e-06 1.75239359197609e-05 1.65042555483732 0.557692307692308 17.4 17 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.67230786689256e-06 1.75239359197609e-05 1.65042555483732 0.557692307692308 17.4 17 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.15619424361057e-08 4.13584923682367e-07 1.64410208527856 0.555555555555556 17.4 17 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.42003381969153e-05 8.14801663476229e-05 1.64410208527856 0.555555555555556 17.4 17 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000102076794257416 0.000472095514812664 1.64410208527856 0.555555555555556 17.4 17 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000754105356062832 0.00268272980419353 1.64410208527856 0.555555555555556 17.4 17 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000754105356062832 0.00268272980419353 1.64410208527856 0.555555555555556 17.4 17 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00585213939002709 0.0153362695248776 1.64410208527856 0.555555555555556 17.4 17 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00585213939002709 0.0153362695248776 1.64410208527856 0.555555555555556 17.4 17 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00585213939002709 0.0153362695248776 1.64410208527856 0.555555555555556 17.4 17 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0509282759949553 0.096756924887612 1.64410208527856 0.555555555555556 17.4 17 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.06460372947099e-05 6.31221294598843e-05 1.63710590619226 0.553191489361702 17.4 17 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00055919823875912 0.0020615002428866 1.63276345020767 0.551724137931034 17.4 17 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00055919823875912 0.0020615002428866 1.63276345020767 0.551724137931034 17.4 17 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 3.18196336521432e-11 7.30311914306447e-10 1.62901857990903 0.55045871559633 17.4 17 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.16490214196967e-10 3.34853885654656e-09 1.62766106442577 0.55 17.4 17 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 5.68902614319711e-05 0.000282072620270714 1.62766106442577 0.55 17.4 17 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00428294989047421 0.0119502699885192 1.62766106442577 0.55 17.4 17 4 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00428294989047421 0.0119502699885192 1.62766106442577 0.55 17.4 17 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00428294989047421 0.0119502699885192 1.62766106442577 0.55 17.4 17 4 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00428294989047421 0.0119502699885192 1.62766106442577 0.55 17.4 17 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00428294989047421 0.0119502699885192 1.62766106442577 0.55 17.4 17 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00428294989047421 0.0119502699885192 1.62766106442577 0.55 17.4 17 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.44502353926855e-48 1.73963424818958e-45 1.6259732029694 0.549429657794677 17.4 17 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.23188733823507e-10 1.96963559809944e-09 1.62196994182288 0.548076923076923 17.4 17 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 4.24626232781681e-05 0.00021580111758869 1.62061491263172 0.547619047619048 17.4 17 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.80953282730704e-07 3.93161834935994e-06 1.61841299019608 0.546875 17.4 17 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.76135951309161e-10 6.83031024159005e-09 1.61420932009167 0.545454545454545 17.4 17 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 4.76135951309161e-10 6.83031024159005e-09 1.61420932009167 0.545454545454545 17.4 17 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000307722442531991 0.00127293324338088 1.61420932009167 0.545454545454545 17.4 17 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00313945054267848 0.00928781314393238 1.61420932009167 0.545454545454545 17.4 17 4 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0359790456149788 0.0717061371290125 1.61420932009167 0.545454545454545 17.4 17 4 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0359790456149788 0.0717061371290125 1.61420932009167 0.545454545454545 17.4 17 4 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0359790456149788 0.0717061371290125 1.61420932009167 0.545454545454545 17.4 17 4 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0359790456149788 0.0717061371290125 1.61420932009167 0.545454545454545 17.4 17 4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0359790456149788 0.0717061371290125 1.61420932009167 0.545454545454545 17.4 17 4 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0359790456149788 0.0717061371290125 1.61420932009167 0.545454545454545 17.4 17 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.365306428221e-05 0.000128466833868644 1.60836073559859 0.543478260869565 17.4 17 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000228379042612574 0.000970099634739381 1.60652260904362 0.542857142857143 17.4 17 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000228379042612574 0.000970099634739381 1.60652260904362 0.542857142857143 17.4 17 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.20824255310584e-37 3.43865830613923e-35 1.60473626070146 0.542253521126761 17.4 17 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.52965411544315e-10 2.41855311808401e-09 1.60415194115029 0.542056074766355 17.4 17 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00230460248592287 0.0070911433837677 1.60299953314659 0.541666666666667 17.4 17 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00230460248592287 0.0070911433837677 1.60299953314659 0.541666666666667 17.4 17 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.03872712567441e-09 1.3814099998455e-08 1.600483050363 0.540816326530612 17.4 17 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.31761570842287e-05 7.65292715545203e-05 1.59806722689076 0.54 17.4 17 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 7.78371304903425e-26 1.10762236687757e-23 1.59584516400417 0.539249146757679 17.4 17 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00169402072556502 0.00538078458142638 1.59351432880845 0.538461538461538 17.4 17 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00169402072556502 0.00538078458142638 1.59351432880845 0.538461538461538 17.4 17 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00169402072556502 0.00538078458142638 1.59351432880845 0.538461538461538 17.4 17 4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0256325878073601 0.0529392923800776 1.59351432880845 0.538461538461538 17.4 17 4 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0256325878073601 0.0529392923800776 1.59351432880845 0.538461538461538 17.4 17 4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0256325878073601 0.0529392923800776 1.59351432880845 0.538461538461538 17.4 17 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0256325878073601 0.0529392923800776 1.59351432880845 0.538461538461538 17.4 17 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 9.35469298316048e-05 0.000436450102132373 1.58796201407392 0.536585365853659 17.4 17 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 9.07369021863562e-23 1.17380556191986e-20 1.58740890992412 0.53639846743295 17.4 17 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.48063738334148e-06 3.37616753095018e-05 1.58538415366146 0.535714285714286 17.4 17 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00124673114756579 0.00412581028601424 1.58538415366146 0.535714285714286 17.4 17 4 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00124673114756579 0.00412581028601424 1.58538415366146 0.535714285714286 17.4 17 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 6.95209319964228e-05 0.000330863833548193 1.58292619373331 0.534883720930233 17.4 17 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.50584077881957e-14 7.14270476086751e-13 1.57954838377069 0.533742331288344 17.4 17 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0183790179239985 0.0396864074443851 1.57833800186741 0.533333333333333 17.4 17 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0183790179239985 0.0396864074443851 1.57833800186741 0.533333333333333 17.4 17 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0183790179239985 0.0396864074443851 1.57833800186741 0.533333333333333 17.4 17 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.03921608613323e-07 9.41913688259612e-07 1.57334326135517 0.531645569620253 17.4 17 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 2.85901010320718e-05 0.000149572477090582 1.57028525695993 0.530612244897959 17.4 17 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 2.85901010320718e-05 0.000149572477090582 1.57028525695993 0.530612244897959 17.4 17 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.02294878083412e-14 5.25095276859003e-13 1.56673257538309 0.529411764705882 17.4 17 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 9.54893367567451e-11 1.617634835772e-09 1.56673257538309 0.529411764705882 17.4 17 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000500141385121018 0.00186309212310788 1.56673257538309 0.529411764705882 17.4 17 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000500141385121018 0.00186309212310788 1.56673257538309 0.529411764705882 17.4 17 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000500141385121018 0.00186309212310788 1.56673257538309 0.529411764705882 17.4 17 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0132450726029539 0.0302531915152543 1.56673257538309 0.529411764705882 17.4 17 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0132450726029539 0.0302531915152543 1.56673257538309 0.529411764705882 17.4 17 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0132450726029539 0.0302531915152543 1.56673257538309 0.529411764705882 17.4 17 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 7.16340194043579e-11 1.35913612816535e-09 1.5652938861495 0.528925619834711 17.4 17 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 7.16340194043579e-11 1.35913612816535e-09 1.5652938861495 0.528925619834711 17.4 17 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 3.26310437376652e-08 3.3893412582991e-07 1.56473163978235 0.528735632183908 17.4 17 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 3.26310437376652e-08 3.3893412582991e-07 1.56473163978235 0.528735632183908 17.4 17 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 7.10052106547132e-07 5.18155973136702e-06 1.56424569827931 0.528571428571429 17.4 17 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.30478371804012e-07 3.93161834935994e-06 1.56189698101463 0.527777777777778 17.4 17 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 1.17890750292839e-05 6.90364352537902e-05 1.56040234275528 0.527272727272727 17.4 17 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.16582207960279e-14 9.94182199766055e-13 1.5584920358676 0.526627218934911 17.4 17 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00958458293214002 0.0228074607231359 1.55757039657968 0.526315789473684 17.4 17 4 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00958458293214002 0.0228074607231359 1.55757039657968 0.526315789473684 17.4 17 4 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00958458293214002 0.0228074607231359 1.55757039657968 0.526315789473684 17.4 17 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 4.87272625607788e-06 3.02789932855844e-05 1.55246360839418 0.524590163934426 17.4 17 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.87272625607788e-06 3.02789932855844e-05 1.55246360839418 0.524590163934426 17.4 17 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.23640783003634e-07 1.10654612713316e-06 1.55187196829952 0.524390243902439 17.4 17 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.000149739667040386 0.000645695594540816 1.55015339469121 0.523809523809524 17.4 17 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.006959411403604 0.0175278627032363 1.55015339469121 0.523809523809524 17.4 17 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.006959411403604 0.0175278627032363 1.55015339469121 0.523809523809524 17.4 17 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.63140986483361e-06 2.31726288684225e-05 1.55015339469121 0.523809523809524 17.4 17 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.63140986483361e-06 2.31726288684225e-05 1.55015339469121 0.523809523809524 17.4 17 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.80542691342589e-09 2.33556590709549e-08 1.5488363569727 0.523364485981308 17.4 17 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.86214092604885e-08 3.87030037870951e-07 1.54545596016184 0.522222222222222 17.4 17 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0050677972530165 0.0135554050583505 1.54402630617464 0.521739130434783 17.4 17 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0050677972530165 0.0135554050583505 1.54402630617464 0.521739130434783 17.4 17 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 8.37410913666887e-07 6.07977413340806e-06 1.54050113195963 0.520547945205479 17.4 17 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.78499069237632e-10 2.79125467610056e-09 1.53984195304138 0.520325203252033 17.4 17 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00369940451702925 0.0106348537933992 1.53887955182073 0.52 17.4 17 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00369940451702925 0.0106348537933992 1.53887955182073 0.52 17.4 17 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.49750971506457e-11 1.40381004270222e-09 1.53704427507437 0.51937984496124 17.4 17 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.20537930207778e-11 8.84109860962699e-10 1.53531939091426 0.518796992481203 17.4 17 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.73209695180875e-13 1.4327178643455e-11 1.53518032212885 0.51875 17.4 17 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00270623727733658 0.00814159755951365 1.53449527959332 0.518518518518518 17.4 17 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00270623727733658 0.00814159755951365 1.53449527959332 0.518518518518518 17.4 17 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00270623727733658 0.00814159755951365 1.53449527959332 0.518518518518518 17.4 17 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00270623727733658 0.00814159755951365 1.53449527959332 0.518518518518518 17.4 17 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00198337354985866 0.00620294628889861 1.53071573456969 0.517241379310345 17.4 17 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.00198337354985866 0.00620294628889861 1.53071573456969 0.517241379310345 17.4 17 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.71586980651249e-10 5.45121931408997e-09 1.52820636451302 0.516393442622951 17.4 17 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00107035492800557 0.00357538747077918 1.52453102453102 0.515151515151515 17.4 17 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000787889747777011 0.00276831385453503 1.52196878751501 0.514285714285714 17.4 17 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.74842238858308e-06 1.1735872919593e-05 1.52079442888266 0.513888888888889 17.4 17 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000580640892640427 0.00213085823760389 1.51968354909531 0.513513513513513 17.4 17 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 9.7122612230946e-07 6.87589438829036e-06 1.51863113666519 0.513157894736842 17.4 17 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 9.7122612230946e-07 6.87589438829036e-06 1.51863113666519 0.513157894736842 17.4 17 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000316312638834191 0.0012897217336993 1.51578192252511 0.51219512195122 17.4 17 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.00443369701816e-07 2.54482687551003e-06 1.51492263572096 0.511904761904762 17.4 17 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.00443369701816e-07 2.54482687551003e-06 1.51492263572096 0.511904761904762 17.4 17 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.24168720258245e-07 1.94507371297245e-06 1.5141033157449 0.511627906976744 17.4 17 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.52923437279696e-19 2.11711794852357e-17 1.51383861236802 0.511538461538461 17.4 17 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.08459375272818e-62 1.5433769101322e-59 1.51316906853239 0.51131221719457 17.4 17 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.86611097429726e-05 0.000199328837551631 1.50659536541889 0.509090909090909 17.4 17 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 6.51077199732451e-06 3.94248023497565e-05 1.50177683013504 0.507462686567164 17.4 17 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 3.60591271358162e-06 2.31726288684225e-05 1.50053260740916 0.507042253521127 17.4 17 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.65610690247902e-12 6.87207294950482e-11 1.4977368996379 0.50609756097561 17.4 17 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 6.16619916447463e-07 4.52293887167392e-06 1.4975194897236 0.506024096385542 17.4 17 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.00045479668181e-09 1.34306337328133e-08 1.49134299389047 0.503937007874016 17.4 17 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 7.07061334870396e-13 2.0961422490012e-11 1.48805171786229 0.502824858757062 17.4 17 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.03321628615967e-14 5.25095276859003e-13 1.4796918767507 0.5 17.4 17 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.55076823511663e-08 1.69749476813151e-07 1.4796918767507 0.5 17.4 17 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 5.87574151332414e-05 0.000287325779156709 1.4796918767507 0.5 17.4 17 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00416574340710738 0.0117849957620553 1.4796918767507 0.5 17.4 17 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0402840385307812 0.0784188602316028 1.4796918767507 0.5 17.4 17 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0402840385307812 0.0784188602316028 1.4796918767507 0.5 17.4 17 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0402840385307812 0.0784188602316028 1.4796918767507 0.5 17.4 17 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0402840385307812 0.0784188602316028 1.4796918767507 0.5 17.4 17 4 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0402840385307812 0.0784188602316028 1.4796918767507 0.5 17.4 17 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0402840385307812 0.0784188602316028 1.4796918767507 0.5 17.4 17 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.61785410929749e-11 9.52348753265264e-10 1.4796918767507 0.5 17.4 17 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.07603830608054e-08 2.22120489440046e-07 1.4796918767507 0.5 17.4 17 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 8.94292992599115e-08 8.2101866352809e-07 1.4796918767507 0.5 17.4 17 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 5.46340303858015e-06 3.37616753095018e-05 1.4796918767507 0.5 17.4 17 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 2.40366176502034e-05 0.000130053638464789 1.4796918767507 0.5 17.4 17 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 7.92311291857987e-05 0.000373330784209906 1.4796918767507 0.5 17.4 17 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000888021611736335 0.00307458577494113 1.4796918767507 0.5 17.4 17 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00120623911654451 0.00401985541649378 1.4796918767507 0.5 17.4 17 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00304817516466568 0.00903656929024847 1.4796918767507 0.5 17.4 17 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00570478830849348 0.0150331736351597 1.4796918767507 0.5 17.4 17 4 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00783099202011011 0.0194759840495082 1.4796918767507 0.5 17.4 17 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00783099202011011 0.0194759840495082 1.4796918767507 0.5 17.4 17 4 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00783099202011011 0.0194759840495082 1.4796918767507 0.5 17.4 17 4 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0206380058158807 0.0438293218247528 1.4796918767507 0.5 17.4 17 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0206380058158807 0.0438293218247528 1.4796918767507 0.5 17.4 17 4 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0287484376253315 0.058274966867303 1.4796918767507 0.5 17.4 17 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0287484376253315 0.058274966867303 1.4796918767507 0.5 17.4 17 4 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0287484376253315 0.058274966867303 1.4796918767507 0.5 17.4 17 4 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0568790382985603 0.105940931281219 1.4796918767507 0.5 17.4 17 4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0568790382985603 0.105940931281219 1.4796918767507 0.5 17.4 17 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0568790382985603 0.105940931281219 1.4796918767507 0.5 17.4 17 4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0568790382985603 0.105940931281219 1.4796918767507 0.5 17.4 17 4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0568790382985603 0.105940931281219 1.4796918767507 0.5 17.4 17 4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0568790382985603 0.105940931281219 1.4796918767507 0.5 17.4 17 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.30164746647503e-18 9.74865444628402e-17 1.4796918767507 0.5 17.4 17 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.06651179260478e-06 2.57184279150071e-05 1.4796918767507 0.5 17.4 17 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.06651179260478e-06 2.57184279150071e-05 1.4796918767507 0.5 17.4 17 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00065449995427834 0.00238197809447079 1.4796918767507 0.5 17.4 17 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00164056847089014 0.00524613243612736 1.4796918767507 0.5 17.4 17 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0107793722645295 0.025353796251943 1.4796918767507 0.5 17.4 17 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0107793722645295 0.025353796251943 1.4796918767507 0.5 17.4 17 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0107793722645295 0.025353796251943 1.4796918767507 0.5 17.4 17 4 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0811277160179789 0.143946059717686 1.4796918767507 0.5 17.4 17 4 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0811277160179789 0.143946059717686 1.4796918767507 0.5 17.4 17 4 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0811277160179789 0.143946059717686 1.4796918767507 0.5 17.4 17 4 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0811277160179789 0.143946059717686 1.4796918767507 0.5 17.4 17 4 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0811277160179789 0.143946059717686 1.4796918767507 0.5 17.4 17 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 5.40505188770043e-09 6.5738366121348e-08 1.46766186149256 0.495934959349593 17.4 17 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.37119708380862e-06 2.20055662855948e-05 1.46096159982981 0.493670886075949 17.4 17 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.47537070107536e-05 8.33116074456441e-05 1.45824706694272 0.492753623188406 17.4 17 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.47537070107536e-05 8.33116074456441e-05 1.45824706694272 0.492753623188406 17.4 17 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.47509182657223e-12 4.03664551771592e-11 1.45595350439641 0.491978609625668 17.4 17 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 4.8358803599349e-05 0.000242304850429132 1.45543463286954 0.491803278688525 17.4 17 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 6.51369877060991e-05 0.000313141667249253 1.45461235341594 0.491525423728814 17.4 17 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 3.44158787220058e-08 3.54882575517494e-07 1.45373237014104 0.491228070175439 17.4 17 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.000118352219362808 0.000524657969324848 1.45278838808251 0.490909090909091 17.4 17 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000118352219362808 0.000524657969324848 1.45278838808251 0.490909090909091 17.4 17 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000118352219362808 0.000524657969324848 1.45278838808251 0.490909090909091 17.4 17 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.000118352219362808 0.000524657969324848 1.45278838808251 0.490909090909091 17.4 17 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000118352219362808 0.000524657969324848 1.45278838808251 0.490909090909091 17.4 17 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 8.51114400493749e-11 1.51391973987826e-09 1.45177316209503 0.490566037735849 17.4 17 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000393503477628346 0.00158627605854146 1.44820907086239 0.48936170212766 17.4 17 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.54741621375071e-09 2.02015896529106e-08 1.44775608084961 0.489208633093525 17.4 17 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000720669821735848 0.0025896796877023 1.4452804377565 0.488372093023256 17.4 17 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.61889460404246e-05 9.06963394311975e-05 1.43858932461874 0.486111111111111 17.4 17 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 2.17532534612288e-05 0.000119516909943354 1.43741496598639 0.485714285714286 17.4 17 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00244587615383031 0.00745285174925168 1.43741496598639 0.485714285714286 17.4 17 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 7.23700884358826e-09 8.44119965936565e-08 1.43485272897038 0.484848484848485 17.4 17 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 5.28833031772333e-05 0.000263122169304906 1.43345150560224 0.484375 17.4 17 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.26048709054835e-10 4.83299284359407e-09 1.43256793163125 0.484076433121019 17.4 17 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00454086954203476 0.0124024133556919 1.43195988072648 0.483870967741935 17.4 17 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 9.57952820979577e-05 0.000445479367403248 1.43036881419234 0.483333333333333 17.4 17 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000129014924686589 0.000570149806922411 1.42866801893171 0.482758620689655 17.4 17 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00023435069419345 0.000992503088801427 1.42488847390808 0.481481481481481 17.4 17 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00848915712313916 0.0205443377316786 1.42488847390808 0.481481481481481 17.4 17 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.40555484329456e-08 1.55046863721562e-07 1.42321508756174 0.480916030534351 17.4 17 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.40555484329456e-08 1.55046863721562e-07 1.42321508756174 0.480916030534351 17.4 17 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.14403501025616e-11 5.08493636599086e-10 1.423091641028 0.480874316939891 17.4 17 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.31916726208355e-10 8.81585785680871e-09 1.42278065072183 0.480769230769231 17.4 17 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000426625811878252 0.00162758319116019 1.42050420168067 0.48 17.4 17 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0116447650998771 0.0270759815966096 1.42050420168067 0.48 17.4 17 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0116447650998771 0.0270759815966096 1.42050420168067 0.48 17.4 17 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0116447650998771 0.0270759815966096 1.42050420168067 0.48 17.4 17 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0116447650998771 0.0270759815966096 1.42050420168067 0.48 17.4 17 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.37960636608066e-09 7.69337276180743e-08 1.41627651060424 0.478571428571429 17.4 17 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000778643847065309 0.00274259949102459 1.41535744732676 0.478260869565217 17.4 17 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0160149826917498 0.0355252355299092 1.41535744732676 0.478260869565217 17.4 17 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.22056295551219e-29 2.48123012241978e-27 1.41318887105404 0.47752808988764 17.4 17 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 7.67656088992057e-05 0.000362915154364019 1.41139840551605 0.476923076923077 17.4 17 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0220924019467166 0.0464364667210896 1.40923035881019 0.476190476190476 17.4 17 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0220924019467166 0.0464364667210896 1.40923035881019 0.476190476190476 17.4 17 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0220924019467166 0.0464364667210896 1.40923035881019 0.476190476190476 17.4 17 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 6.86835545984138e-09 8.07741307384652e-08 1.40725940725941 0.475524475524476 17.4 17 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.30775554439944e-09 1.72308901822259e-08 1.40477076906712 0.474683544303797 17.4 17 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.68363140236721e-11 6.26034014027631e-10 1.40262459150327 0.473958333333333 17.4 17 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.46320245084217e-11 1.51391973987826e-09 1.39927383997077 0.472826086956522 17.4 17 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.30914672640297e-12 3.65277606210083e-11 1.39898141074612 0.472727272727273 17.4 17 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 6.90818910051318e-08 6.51016760929156e-07 1.39813405677232 0.47244094488189 17.4 17 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00355502508192813 0.0102612590092976 1.39748677248677 0.472222222222222 17.4 17 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00355502508192813 0.0102612590092976 1.39748677248677 0.472222222222222 17.4 17 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00355502508192813 0.0102612590092976 1.39748677248677 0.472222222222222 17.4 17 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000455780794872275 0.00171128250950725 1.39593573278368 0.471698113207547 17.4 17 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.74494204394629e-08 1.895459945447e-07 1.39513805522209 0.471428571428571 17.4 17 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 6.10382203822452e-05 0.000296441595917867 1.39513805522209 0.471428571428571 17.4 17 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00483185441275667 0.013085865009169 1.39265117811831 0.470588235294118 17.4 17 4 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0425292065341115 0.0823388583646812 1.39265117811831 0.470588235294118 17.4 17 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0425292065341115 0.0823388583646812 1.39265117811831 0.470588235294118 17.4 17 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00010993560671111 0.000501405026762529 1.39001358119005 0.46969696969697 17.4 17 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.28202073359787e-19 1.1401971899436e-17 1.38473838733354 0.467914438502674 17.4 17 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.74477518148053e-07 1.53226123770313e-06 1.38422788470227 0.467741935483871 17.4 17 4 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0594509315617163 0.109868409886133 1.38104575163399 0.466666666666667 17.4 17 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0594509315617163 0.109868409886133 1.38104575163399 0.466666666666667 17.4 17 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0594509315617163 0.109868409886133 1.38104575163399 0.466666666666667 17.4 17 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.7165695840576e-12 9.44406878234635e-11 1.38016103302307 0.466367713004484 17.4 17 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00203820702230587 0.00636045744022203 1.37645755976809 0.465116279069767 17.4 17 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 8.80078036980567e-09 1.00996052147044e-07 1.37468148549742 0.464516129032258 17.4 17 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0122361156770333 0.0283121831031194 1.37399959983994 0.464285714285714 17.4 17 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0122361156770333 0.0283121831031194 1.37399959983994 0.464285714285714 17.4 17 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0122361156770333 0.0283121831031194 1.37399959983994 0.464285714285714 17.4 17 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.30746832815946e-06 9.21053183648964e-06 1.37207792207792 0.463636363636364 17.4 17 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.344393957933e-12 6.17791222618271e-11 1.37173152522812 0.463519313304721 17.4 17 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00275541449389936 0.0082546417364606 1.37142173942748 0.463414634146341 17.4 17 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00275541449389936 0.0082546417364606 1.37142173942748 0.463414634146341 17.4 17 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.36033351395702e-07 3.64985564138873e-06 1.36963215038081 0.462809917355372 17.4 17 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0167361737782059 0.0365269559607162 1.36586942469295 0.461538461538462 17.4 17 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0167361737782059 0.0365269559607162 1.36586942469295 0.461538461538462 17.4 17 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0836617101481607 0.146614056084769 1.36586942469295 0.461538461538462 17.4 17 4 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0836617101481607 0.146614056084769 1.36586942469295 0.461538461538462 17.4 17 4 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0836617101481607 0.146614056084769 1.36586942469295 0.461538461538462 17.4 17 4 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0836617101481607 0.146614056084769 1.36586942469295 0.461538461538462 17.4 17 4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0836617101481607 0.146614056084769 1.36586942469295 0.461538461538462 17.4 17 4 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0836617101481607 0.146614056084769 1.36586942469295 0.461538461538462 17.4 17 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 6.78146537958116e-05 0.000323826350172617 1.36287409700722 0.460526315789474 17.4 17 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.4034446094274e-21 1.42650119943942e-19 1.36025486427755 0.459641255605381 17.4 17 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00157568142649516 0.0050613875167102 1.35638422035481 0.458333333333333 17.4 17 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0229398978754449 0.0480051098187619 1.35638422035481 0.458333333333333 17.4 17 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0229398978754449 0.0480051098187619 1.35638422035481 0.458333333333333 17.4 17 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000502131675765284 0.00186562238802611 1.35429426007691 0.457627118644068 17.4 17 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.79014049215395e-08 1.92982569722354e-07 1.35021883753501 0.45625 17.4 17 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00285914820620542 0.00851164832098392 1.34517443340973 0.454545454545455 17.4 17 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00285914820620542 0.00851164832098392 1.34517443340973 0.454545454545455 17.4 17 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00285914820620542 0.00851164832098392 1.34517443340973 0.454545454545455 17.4 17 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00928083636996541 0.0223084968825351 1.34517443340973 0.454545454545455 17.4 17 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00928083636996541 0.0223084968825351 1.34517443340973 0.454545454545455 17.4 17 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00928083636996541 0.0223084968825351 1.34517443340973 0.454545454545455 17.4 17 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00928083636996541 0.0223084968825351 1.34517443340973 0.454545454545455 17.4 17 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0315199266818725 0.0637114427106599 1.34517443340973 0.454545454545455 17.4 17 4 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.118751608020479 0.196721231912854 1.34517443340973 0.454545454545455 17.4 17 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 7.96846227013138e-45 3.77970727013232e-42 1.34490512921885 0.454454454454454 17.4 17 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.78502985867321e-09 3.57035809810087e-08 1.34223416142413 0.453551912568306 17.4 17 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00038833741412675 0.00156989812585899 1.34097076330532 0.453125 17.4 17 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.46859398103728e-10 3.7370311010809e-09 1.33876884086968 0.452380952380952 17.4 17 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0126043220802246 0.0289756871084969 1.33649588867805 0.451612903225806 17.4 17 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.40097921087148e-05 8.07122840919078e-05 1.33172268907563 0.45 17.4 17 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000695115555767406 0.00250417578697979 1.33172268907563 0.45 17.4 17 4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0434314349509721 0.0838574381753505 1.33172268907563 0.45 17.4 17 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.34568076643392e-21 1.42650119943942e-19 1.329316686024 0.449186991869919 17.4 17 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00218464898116177 0.00680252844681224 1.32870290973532 0.448979591836735 17.4 17 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000129804505570928 0.00057186319327378 1.32792860734037 0.448717948717949 17.4 17 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000930063391389718 0.00321233059696012 1.32662030329373 0.448275862068966 17.4 17 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0171383293379345 0.0372902792781053 1.32662030329373 0.448275862068966 17.4 17 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.23571560976568e-14 6.0635286644709e-13 1.32536818408345 0.447852760736196 17.4 17 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.41640232689948e-07 1.25971281948622e-06 1.31740309026837 0.445161290322581 17.4 17 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000133030745618512 0.000584267750046735 1.31528166822284 0.444444444444444 17.4 17 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0233337871022592 0.0487325061678456 1.31528166822284 0.444444444444444 17.4 17 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0600421671086962 0.110673580046211 1.31528166822284 0.444444444444444 17.4 17 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0600421671086962 0.110673580046211 1.31528166822284 0.444444444444444 17.4 17 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 4.60589705582269e-32 1.09236525173928e-29 1.31486064336106 0.444302176696543 17.4 17 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.000102182303979129 0.000472095514812664 1.30763468177969 0.441860465116279 17.4 17 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0127931905467092 0.0293624357225276 1.30561047948591 0.441176470588235 17.4 17 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 3.4289017766773e-05 0.000178077636066124 1.30212885154062 0.44 17.4 17 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000103860437134567 0.000478295799490255 1.29680861108488 0.438202247191011 17.4 17 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00398932187131625 0.011353610045766 1.29473039215686 0.4375 17.4 17 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00398932187131625 0.011353610045766 1.29473039215686 0.4375 17.4 17 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0172930607153945 0.0375122338384244 1.29473039215686 0.4375 17.4 17 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0172930607153945 0.0375122338384244 1.29473039215686 0.4375 17.4 17 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.083330649067793 0.146614056084769 1.29473039215686 0.4375 17.4 17 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000105104771567806 0.000480913472479063 1.28668858847887 0.434782608695652 17.4 17 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00533747875714261 0.0141175321029999 1.28668858847887 0.434782608695652 17.4 17 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.000138948385536321 0.000600983442608466 1.28239962651727 0.433333333333333 17.4 17 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.023390233107968 0.0487325061678456 1.28239962651727 0.433333333333333 17.4 17 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.023390233107968 0.0487325061678456 1.28239962651727 0.433333333333333 17.4 17 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00128872886466528 0.0042548983165167 1.27481146304676 0.430769230769231 17.4 17 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 8.91377363342971e-11 1.55434928170903e-09 1.27135980746089 0.429602888086643 17.4 17 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 6.15256823299131e-05 0.000297582873384109 1.26830732292917 0.428571428571429 17.4 17 4 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0316570406711787 0.0638073213528148 1.26830732292917 0.428571428571429 17.4 17 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.116194963861195 0.196605747413176 1.26830732292917 0.428571428571429 17.4 17 4 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.116194963861195 0.196605747413176 1.26830732292917 0.428571428571429 17.4 17 4 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.116194963861195 0.196605747413176 1.26830732292917 0.428571428571429 17.4 17 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.116194963861195 0.196605747413176 1.26830732292917 0.428571428571429 17.4 17 4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.116194963861195 0.196605747413176 1.26830732292917 0.428571428571429 17.4 17 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00955105465761252 0.0228074607231359 1.26830732292917 0.428571428571429 17.4 17 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00955105465761252 0.0228074607231359 1.26830732292917 0.428571428571429 17.4 17 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0594357097041638 0.109868409886133 1.26830732292917 0.428571428571429 17.4 17 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0594357097041638 0.109868409886133 1.26830732292917 0.428571428571429 17.4 17 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000974340043822927 0.00335710867399522 1.26830732292917 0.428571428571429 17.4 17 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000422547785527841 0.00162380383548764 1.26315160210426 0.426829268292683 17.4 17 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000421640807145842 0.00162380383548764 1.25338606030648 0.423529411764706 17.4 17 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000421640807145842 0.00162380383548764 1.25338606030648 0.423529411764706 17.4 17 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000421640807145842 0.00162380383548764 1.25338606030648 0.423529411764706 17.4 17 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000421640807145842 0.00162380383548764 1.25338606030648 0.423529411764706 17.4 17 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000421640807145842 0.00162380383548764 1.25338606030648 0.423529411764706 17.4 17 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000421640807145842 0.00162380383548764 1.25338606030648 0.423529411764706 17.4 17 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000421640807145842 0.00162380383548764 1.25338606030648 0.423529411764706 17.4 17 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0053144805087208 0.0140828785175227 1.25204697263521 0.423076923076923 17.4 17 4 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0428721906601459 0.0828901186268853 1.25204697263521 0.423076923076923 17.4 17 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00947968366979429 0.0227480436123394 1.2495175848117 0.422222222222222 17.4 17 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 8.06986047165642e-05 0.000378990476936208 1.24891424459692 0.422018348623853 17.4 17 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000554857780313467 0.00205615265985954 1.247932908103 0.421686746987952 17.4 17 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0814647712522954 0.144184539169175 1.24605631726375 0.421052631578947 17.4 17 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0814647712522954 0.144184539169175 1.24605631726375 0.421052631578947 17.4 17 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000419308555013194 0.00162380383548764 1.244286350904 0.420454545454545 17.4 17 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000729678620137311 0.00260887607149596 1.24221046443269 0.419753086419753 17.4 17 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000729678620137311 0.00260887607149596 1.24221046443269 0.419753086419753 17.4 17 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.031180057739116 0.0631141140295335 1.24103189662962 0.419354838709677 17.4 17 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00525830172458835 0.0139600062576291 1.23756047873695 0.418181818181818 17.4 17 4 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0228196164408266 0.0478942687246257 1.23307656395892 0.416666666666667 17.4 17 4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0580945986734388 0.108063547597782 1.23307656395892 0.416666666666667 17.4 17 4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.162946300678993 0.260824056092471 1.23307656395892 0.416666666666667 17.4 17 4 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.162946300678993 0.260824056092471 1.23307656395892 0.416666666666667 17.4 17 4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.162946300678993 0.260824056092471 1.23307656395892 0.416666666666667 17.4 17 4 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.162946300678993 0.260824056092471 1.23307656395892 0.416666666666667 17.4 17 4 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.162946300678993 0.260824056092471 1.23307656395892 0.416666666666667 17.4 17 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.74405600664289e-20 6.39786113163522e-18 1.22885763947881 0.415241057542768 17.4 17 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00517936454871811 0.013776141594067 1.22457258765575 0.413793103448276 17.4 17 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00517936454871811 0.013776141594067 1.22457258765575 0.413793103448276 17.4 17 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00517936454871811 0.013776141594067 1.22457258765575 0.413793103448276 17.4 17 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.012394568608327 0.0285858527222841 1.22235415905493 0.41304347826087 17.4 17 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.11189165884137 0.190456735085251 1.21856978085352 0.411764705882353 17.4 17 4 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.11189165884137 0.190456735085251 1.21856978085352 0.411764705882353 17.4 17 4 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.11189165884137 0.190456735085251 1.21856978085352 0.411764705882353 17.4 17 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.56606828710259e-05 0.000135744058458996 1.21733516101476 0.411347517730496 17.4 17 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 8.27059279918424e-17 5.88452677661959e-15 1.21277722998131 0.409807355516637 17.4 17 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.71130187813624e-08 3.74551955502686e-07 1.20958939131208 0.408730158730159 17.4 17 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.71130187813624e-08 3.74551955502686e-07 1.20958939131208 0.408730158730159 17.4 17 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.71130187813624e-08 3.74551955502686e-07 1.20958939131208 0.408730158730159 17.4 17 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00159231233526475 0.00510328930874266 1.20567486253761 0.407407407407407 17.4 17 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0406816872816623 0.0790847554669473 1.20224964985994 0.40625 17.4 17 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.1036950757999e-41 3.92639523215816e-39 1.19980180580948 0.405422853453841 17.4 17 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0756145677515657 0.135175288832259 1.18375350140056 0.4 17.4 17 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0756145677515657 0.135175288832259 1.18375350140056 0.4 17.4 17 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0756145677515657 0.135175288832259 1.18375350140056 0.4 17.4 17 4 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.106820328786511 0.182479385189921 1.18375350140056 0.4 17.4 17 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.106820328786511 0.182479385189921 1.18375350140056 0.4 17.4 17 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.154024318727514 0.252217037455987 1.18375350140056 0.4 17.4 17 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.154024318727514 0.252217037455987 1.18375350140056 0.4 17.4 17 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.154024318727514 0.252217037455987 1.18375350140056 0.4 17.4 17 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0149889826024106 0.0338980921348789 1.17258601553829 0.39622641509434 17.4 17 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 6.50480058381244e-06 3.94248023497565e-05 1.17173569935588 0.395939086294416 17.4 17 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0203131630607585 0.0437964106597868 1.17142273576097 0.395833333333333 17.4 17 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000422686149695457 0.00162380383548764 1.16434770629563 0.39344262295082 17.4 17 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.0722534211523787 0.130864033200174 1.16261504601841 0.392857142857143 17.4 17 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000987377354862101 0.00339381153615645 1.16162726772952 0.392523364485981 17.4 17 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0103376023177943 0.024558277292523 1.15600927871148 0.390625 17.4 17 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.144886789943981 0.238076099411414 1.15087145969499 0.388888888888889 17.4 17 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.000117308367804565 0.000524657969324848 1.14982426091456 0.388535031847134 17.4 17 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0255027037220414 0.0529392923800776 1.14751614931687 0.387755102040816 17.4 17 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0133848753320786 0.0305235217909421 1.14556790458119 0.387096774193548 17.4 17 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0688189929992283 0.125069510904089 1.14556790458119 0.387096774193548 17.4 17 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0474954197268698 0.0914559976608061 1.13822452057746 0.384615384615385 17.4 17 4 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.212499169760763 0.328323907241656 1.13822452057746 0.384615384615385 17.4 17 4 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.212499169760763 0.328323907241656 1.13822452057746 0.384615384615385 17.4 17 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.212499169760763 0.328323907241656 1.13822452057746 0.384615384615385 17.4 17 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.0123126496873125 0.0284430203003987 1.13152908222112 0.382352941176471 17.4 17 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.16914600480056e-05 0.000297582873384109 1.12518236461251 0.380208333333333 17.4 17 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.031635387957342 0.0638073213528148 1.12456582633053 0.38 17.4 17 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000184618166166827 0.000791300151974079 1.11837176731158 0.377906976744186 17.4 17 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0212756315595806 0.0449187295389958 1.11583321853332 0.377049180327869 17.4 17 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0055411845332673 0.0146291383874571 1.11374657389838 0.376344086021505 17.4 17 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.196440520523347 0.306507522702547 1.10976890756303 0.375 17.4 17 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0808233561967693 0.143946059717686 1.09919967987195 0.371428571428571 17.4 17 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.119474853626356 0.197459601289553 1.09606805685237 0.37037037037037 17.4 17 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.119474853626356 0.197459601289553 1.09606805685237 0.37037037037037 17.4 17 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.00810084719684279 0.0196379992523122 1.09029927760578 0.368421052631579 17.4 17 4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.181882967514131 0.285357731833085 1.09029927760578 0.368421052631579 17.4 17 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00631711333354494 0.0159667003084093 1.07613954672778 0.363636363636364 17.4 17 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.044490086381354 0.085785085258356 1.07613954672778 0.363636363636364 17.4 17 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.104932528227182 0.181896233021539 1.07613954672778 0.363636363636364 17.4 17 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.104932528227182 0.181896233021539 1.07613954672778 0.363636363636364 17.4 17 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.104932528227182 0.181896233021539 1.07613954672778 0.363636363636364 17.4 17 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.168676136288995 0.269389609359416 1.07613954672778 0.363636363636364 17.4 17 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0012356570783618 0.00410827108062814 1.07118798439621 0.361963190184049 17.4 17 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00153587988078269 0.00494469925419406 1.06611340188249 0.360248447204969 17.4 17 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0922483748369088 0.160869408569756 1.0623428858723 0.358974358974359 17.4 17 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0922483748369088 0.160869408569756 1.0623428858723 0.358974358974359 17.4 17 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0922483748369088 0.160869408569756 1.0623428858723 0.358974358974359 17.4 17 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0018115468469903 0.00569057651935364 1.05953245495729 0.358024691358025 17.4 17 4 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.266001506371634 0.38048832680743 1.05692276910764 0.357142857142857 17.4 17 4 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.266001506371634 0.38048832680743 1.05692276910764 0.357142857142857 17.4 17 4 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.266001506371634 0.38048832680743 1.05692276910764 0.357142857142857 17.4 17 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0865368096307239 0.151466027188832 1.05692276910764 0.357142857142857 17.4 17 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.126496714771728 0.20882230292363 1.04448838358873 0.352941176470588 17.4 17 4 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.242558081440789 0.367191648819407 1.04448838358873 0.352941176470588 17.4 17 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0237888429700271 0.0494905315005096 1.04251018589254 0.352272727272727 17.4 17 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00324051110234223 0.00954709585638302 1.04229868047848 0.352201257861635 17.4 17 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00324051110234223 0.00954709585638302 1.04229868047848 0.352201257861635 17.4 17 4 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.222301311444388 0.341983531011204 1.03578431372549 0.35 17.4 17 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00489304036645762 0.013137351776357 1.03101111412307 0.348387096774194 17.4 17 4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.204522257602777 0.318419226005199 1.0293508707831 0.347826086956522 17.4 17 4 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.18873982039603 0.295139301564342 1.02440206851972 0.346153846153846 17.4 17 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.18873982039603 0.295139301564342 1.02440206851972 0.346153846153846 17.4 17 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000593856969944496 0.00216681658520774 1.02127753062009 0.345098039215686 17.4 17 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0697553242274093 0.126609472417862 1.01880424300868 0.344262295081967 17.4 17 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 3.52291818953217e-06 2.28909250397456e-05 1.01635401635402 0.343434343434343 17.4 17 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.139816656940622 0.230010523498851 1.01242075777679 0.342105263157895 17.4 17 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.130213528316698 0.214708981222088 1.01052128168341 0.341463414634146 17.4 17 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0989859622668546 0.172407618489271 1.00507372760425 0.339622641509434 17.4 17 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.13186327348972 0.217177590481334 0.986461251167134 0.333333333333333 17.4 17 4 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.243040038945673 0.367530260807325 0.986461251167134 0.333333333333333 17.4 17 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.205933173708653 0.319566964217463 0.986461251167134 0.333333333333333 17.4 17 4 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.205933173708653 0.319566964217463 0.986461251167134 0.333333333333333 17.4 17 4 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.205933173708653 0.319566964217463 0.986461251167134 0.333333333333333 17.4 17 4 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.291393727189193 0.415068342132354 0.986461251167134 0.333333333333333 17.4 17 4 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.321990100193693 0.455459157629847 0.986461251167134 0.333333333333333 17.4 17 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.321990100193693 0.455459157629847 0.986461251167134 0.333333333333333 17.4 17 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.190340012880824 0.29731486095435 0.986461251167133 0.333333333333333 17.4 17 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.223372303780867 0.342520245991566 0.986461251167133 0.333333333333333 17.4 17 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.223372303780867 0.342520245991566 0.986461251167133 0.333333333333333 17.4 17 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.223372303780867 0.342520245991566 0.986461251167133 0.333333333333333 17.4 17 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0111675017981177 0.0261370971360551 0.97579680520857 0.32972972972973 17.4 17 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0830580065543334 0.146614056084769 0.973481497862303 0.328947368421053 17.4 17 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0263636490750502 0.0543702501939078 0.972368947579032 0.328571428571429 17.4 17 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0279486651492915 0.0575556447285699 0.972060356989511 0.328467153284672 17.4 17 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.163325497172669 0.261137283681695 0.965016441359152 0.326086956521739 17.4 17 4 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.204267225626691 0.318370495144338 0.959800136270724 0.324324324324324 17.4 17 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0335265746456363 0.0673846267242097 0.958673610289186 0.323943661971831 17.4 17 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.037693421483819 0.0750178164636007 0.957447684956335 0.323529411764706 17.4 17 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.239383449601922 0.362771723944126 0.954639920484323 0.32258064516129 17.4 17 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.239383449601922 0.362771723944126 0.954639920484323 0.32258064516129 17.4 17 4 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.260160192676693 0.38048832680743 0.951230492196879 0.321428571428571 17.4 17 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0423038438356388 0.0821260160683683 0.950459015723078 0.321167883211679 17.4 17 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0124969760015095 0.0287753994338966 0.938920949906067 0.317269076305221 17.4 17 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.216706705361519 0.334461650465772 0.93834119013459 0.317073170731707 17.4 17 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0667796116803501 0.12151839823675 0.932089371181544 0.31496062992126 17.4 17 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.183414125985691 0.2874430630811 0.931657848324515 0.314814814814815 17.4 17 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.211720829807718 0.328190349473184 0.924807422969188 0.3125 17.4 17 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.274616448816609 0.392348601070316 0.924807422969188 0.3125 17.4 17 4 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.379058090952942 0.52115909509762 0.924807422969188 0.3125 17.4 17 4 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.379058090952942 0.52115909509762 0.924807422969188 0.3125 17.4 17 4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.379058090952942 0.52115909509762 0.924807422969188 0.3125 17.4 17 4 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.393209658997447 0.53957313862427 0.88781512605042 0.3 17.4 17 4 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.393209658997447 0.53957313862427 0.88781512605042 0.3 17.4 17 4 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.369049765217997 0.513765467243271 0.876854445481897 0.296296296296296 17.4 17 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.221682528746302 0.341400690915571 0.870406986323941 0.294117647058824 17.4 17 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.221682528746302 0.341400690915571 0.870406986323941 0.294117647058824 17.4 17 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.277632988439971 0.396260524122447 0.857792392319247 0.289855072463768 17.4 17 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.25246397507455 0.373596011728308 0.850035758984445 0.287234042553192 17.4 17 4 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.394332819618477 0.540593065816082 0.834697981756805 0.282051282051282 17.4 17 4 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.359918449613938 0.504595028375009 0.830704211509165 0.280701754385965 17.4 17 4 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.450782041131229 0.59560152695426 0.828627450980392 0.28 17.4 17 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.337713873838374 0.47393179730967 0.824132184519377 0.278481012658228 17.4 17 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.406059158577845 0.553027165219759 0.818552953096132 0.276595744680851 17.4 17 4 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.456014078380636 0.601955504207463 0.816381725103835 0.275862068965517 17.4 17 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.286104679697334 0.407942844899104 0.812026029924165 0.274390243902439 17.4 17 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0168478911548633 0.0367144703114401 0.806973423515748 0.272682926829268 17.4 17 4 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.423147063538474 0.575108186643026 0.798563869992441 0.26984126984127 17.4 17 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.470252531179258 0.616392528168345 0.789169000933707 0.266666666666667 17.4 17 4 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.498783680265352 0.643489734376787 0.789169000933707 0.266666666666667 17.4 17 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.498783680265352 0.643489734376787 0.789169000933707 0.266666666666667 17.4 17 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.323764864643715 0.457514798796432 0.789169000933707 0.266666666666667 17.4 17 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.475169513350994 0.619767385424807 0.78172401035886 0.264150943396226 17.4 17 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.544949446817941 0.700508638502195 0.778785198289842 0.263157894736842 17.4 17 4 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.541507648195807 0.696713728194063 0.767247639796659 0.259259259259259 17.4 17 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.540481137073692 0.696022314982682 0.763711936387458 0.258064516129032 17.4 17 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.538241657544085 0.693766194461261 0.749211076835798 0.253164556962025 17.4 17 4 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.589240060191837 0.735516320748232 0.73984593837535 0.25 17.4 17 4 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.595529376091438 0.742715426974686 0.73984593837535 0.25 17.4 17 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.596427676143329 0.743184398556881 0.727717316434771 0.245901639344262 17.4 17 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.614249065864955 0.763385520284568 0.719850102203043 0.243243243243243 17.4 17 4 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.619251717050355 0.76625668988057 0.717426364485188 0.242424242424242 17.4 17 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.619251717050355 0.76625668988057 0.717426364485188 0.242424242424242 17.4 17 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.625348928968473 0.773129040766409 0.714334009465855 0.241379310344828 17.4 17 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.649247231099996 0.796447249875254 0.711390325360914 0.240384615384615 17.4 17 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.674449228505291 0.824519976085077 0.701709549799301 0.237113402061856 17.4 17 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.67381383514538 0.82445149390531 0.682934712346477 0.230769230769231 17.4 17 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.67381383514538 0.82445149390531 0.682934712346477 0.230769230769231 17.4 17 4 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.686417295265371 0.829582403394109 0.672587216704864 0.227272727272727 17.4 17 4 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.699856851909844 0.843265283884596 0.668247944339026 0.225806451612903 17.4 17 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.725513139499495 0.865545334333242 0.664351454867661 0.224489795918367 17.4 17 4 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.746290312844082 0.8886787574704 0.634153661464586 0.214285714285714 17.4 17 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.852157215622517 0.977919127282937 0.627748068924539 0.212121212121212 17.4 17 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.806572933576319 0.93958623175048 0.616538281979458 0.208333333333333 17.4 17 4 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.791918078095155 0.925204782536458 0.609284890426759 0.205882352941176 17.4 17 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.889689665380663 1 0.583540458436896 0.197183098591549 17.4 17 4 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.879227698220562 1 0.54514963880289 0.184210526315789 17.4 17 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.990610901325223 1 0.540962621607783 0.182795698924731 17.4 17 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999733690479493 1 0.533909440064686 0.180412371134021 17.4 17 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.998571491673107 1 0.504595386541714 0.170506912442396 17.4 17 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.99986264493391 1 0.486184473789516 0.164285714285714 17.4 17 4 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.934493470077583 1 0.462403711484594 0.15625 17.4 17 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.434838083008182 0.146935348446683 17.4 17 4 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.976468320443045 1 0.412937267930428 0.13953488372093 17.4 17 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999991001027684 1 0.369922969187675 0.125 17.4 17 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.353199507651162 0.119349005424955 17.4 17 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999927978570649 1 0.328820417055711 0.111111111111111 17.4 17 4 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.997153193360738 1 0.308269140989729 0.104166666666667 17.4 17 4 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999979820335025 1 0.263056333644569 0.0888888888888889 17.4 17 4 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0381855968193729 0.0129032258064516 17.4 17 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 4.31386340927781e-12 5.38476108017748e-11 1.63425997825749 1 18.4 18 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 1.84905511609002e-07 1.05248217207844e-06 1.63425997825749 1 18.4 18 4 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 6.20114466570969e-05 0.000231607056674669 1.63425997825749 1 18.4 18 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00016342514673832 0.000560371045321997 1.63425997825749 1 18.4 18 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00016342514673832 0.000560371045321997 1.63425997825749 1 18.4 18 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00016342514673832 0.000560371045321997 1.63425997825749 1 18.4 18 4 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.000430670340075902 0.00138652464689595 1.63425997825749 1 18.4 18 4 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000430670340075902 0.00138652464689595 1.63425997825749 1 18.4 18 4 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.000430670340075902 0.00138652464689595 1.63425997825749 1 18.4 18 4 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.000430670340075902 0.00138652464689595 1.63425997825749 1 18.4 18 4 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00299043460123577 0.00758536263379411 1.63425997825749 1 18.4 18 4 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00299043460123577 0.00758536263379411 1.63425997825749 1 18.4 18 4 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00787948040389311 0.0180993201515761 1.63425997825749 1 18.4 18 4 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00787948040389311 0.0180993201515761 1.63425997825749 1 18.4 18 4 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00787948040389311 0.0180993201515761 1.63425997825749 1 18.4 18 4 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00787948040389311 0.0180993201515761 1.63425997825749 1 18.4 18 4 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00113488042299389 0.0032493658791153 1.63425997825749 1 18.4 18 4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00113488042299389 0.0032493658791153 1.63425997825749 1 18.4 18 4 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00113488042299389 0.0032493658791153 1.63425997825749 1 18.4 18 4 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00113488042299389 0.0032493658791153 1.63425997825749 1 18.4 18 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.95782584231279e-10 3.87636602945665e-09 1.57140382524759 0.961538461538462 18.4 18 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 8.06732080375286e-09 5.7128474625576e-08 1.56320519659412 0.956521739130435 18.4 18 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 8.06732080375286e-09 5.7128474625576e-08 1.56320519659412 0.956521739130435 18.4 18 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 2.03714144464176e-08 1.40041172740349e-07 1.55997543379124 0.954545454545455 18.4 18 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.29095393253048e-07 7.55978372835751e-07 1.55254697934462 0.95 18.4 18 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 8.10229770175846e-07 4.20787212759208e-06 1.54346775724319 0.944444444444444 18.4 18 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 8.10229770175846e-07 4.20787212759208e-06 1.54346775724319 0.944444444444444 18.4 18 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 2.0211784370888e-06 9.98658651381029e-06 1.53812703835999 0.941176470588235 18.4 18 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 2.0211784370888e-06 9.98658651381029e-06 1.53812703835999 0.941176470588235 18.4 18 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 2.0211784370888e-06 9.98658651381029e-06 1.53812703835999 0.941176470588235 18.4 18 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.19820920391592e-15 2.89175006765768e-14 1.52994551156021 0.936170212765957 18.4 18 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 3.07130090814596e-05 0.00012106540698869 1.51752712266767 0.928571428571429 18.4 18 4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 7.5410468481752e-05 0.000275858860281576 1.50854767223769 0.923076923076923 18.4 18 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000184149141346024 0.000629914009940847 1.49807164673604 0.916666666666667 18.4 18 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.28014505184223e-13 2.02405156530166e-12 1.4889924246346 0.911111111111111 18.4 18 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.000446835680408723 0.0014320882279766 1.48569088932499 0.909090909090909 18.4 18 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000446835680408723 0.0014320882279766 1.48569088932499 0.909090909090909 18.4 18 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 7.82884517460764e-10 5.9574581195009e-09 1.48104810529585 0.90625 18.4 18 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 2.07657693492079e-06 1.02248061536065e-05 1.47083398043174 0.9 18.4 18 4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00107614844746933 0.00316396537344804 1.47083398043174 0.9 18.4 18 4 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00107614844746933 0.00316396537344804 1.47083398043174 0.9 18.4 18 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00107614844746933 0.00316396537344804 1.47083398043174 0.9 18.4 18 4 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00107614844746933 0.00316396537344804 1.47083398043174 0.9 18.4 18 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.47778167899655e-09 3.26763247651902e-08 1.47083398043174 0.9 18.4 18 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.18858165858137e-10 2.62274664749208e-09 1.45267553622888 0.888888888888889 18.4 18 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 1.17087677723924e-05 5.14246189509705e-05 1.45267553622888 0.888888888888889 18.4 18 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 1.17087677723924e-05 5.14246189509705e-05 1.45267553622888 0.888888888888889 18.4 18 4 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00256863188677656 0.00664575122706008 1.45267553622888 0.888888888888889 18.4 18 4 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00256863188677656 0.00664575122706008 1.45267553622888 0.888888888888889 18.4 18 4 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00256863188677656 0.00664575122706008 1.45267553622888 0.888888888888889 18.4 18 4 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00256863188677656 0.00664575122706008 1.45267553622888 0.888888888888889 18.4 18 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 2.75577633389111e-05 0.000113337275234886 1.44199409846249 0.882352941176471 18.4 18 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.28227806134154e-07 1.796416031265e-06 1.43814878086659 0.88 18.4 18 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.28227806134154e-07 1.796416031265e-06 1.43814878086659 0.88 18.4 18 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 5.24788146115971e-11 4.7870098200194e-10 1.43495998090902 0.878048780487805 18.4 18 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 5.24788146115971e-11 4.7870098200194e-10 1.43495998090902 0.878048780487805 18.4 18 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.64403234383796e-07 4.01382214955034e-06 1.42997748097531 0.875 18.4 18 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 7.64403234383796e-07 4.01382214955034e-06 1.42997748097531 0.875 18.4 18 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 6.441794034958e-05 0.000238095400305071 1.42997748097531 0.875 18.4 18 4 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 6.441794034958e-05 0.000238095400305071 1.42997748097531 0.875 18.4 18 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 6.441794034958e-05 0.000238095400305071 1.42997748097531 0.875 18.4 18 4 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 6.441794034958e-05 0.000238095400305071 1.42997748097531 0.875 18.4 18 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0060643510034198 0.0143586879831387 1.42997748097531 0.875 18.4 18 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0060643510034198 0.0143586879831387 1.42997748097531 0.875 18.4 18 4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0060643510034198 0.0143586879831387 1.42997748097531 0.875 18.4 18 4 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0060643510034198 0.0143586879831387 1.42997748097531 0.875 18.4 18 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 8.46661457563873e-12 8.66762053318986e-11 1.42109563326739 0.869565217391304 18.4 18 4 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000149425559612546 0.00052429206220502 1.41635864782316 0.866666666666667 18.4 18 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000149425559612546 0.00052429206220502 1.41635864782316 0.866666666666667 18.4 18 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000149425559612546 0.00052429206220502 1.41635864782316 0.866666666666667 18.4 18 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.49416317105371e-09 1.1249704721743e-08 1.41341403524972 0.864864864864865 18.4 18 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 4.0773923279301e-06 1.94702324920957e-05 1.41140634485874 0.863636363636364 18.4 18 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 6.50851168421655e-15 1.30445241220284e-13 1.40079426707785 0.857142857142857 18.4 18 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.12815463577521e-13 3.2917000507697e-12 1.40079426707785 0.857142857142857 18.4 18 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 9.32931435166023e-06 4.17472148503538e-05 1.40079426707785 0.857142857142857 18.4 18 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000343595224883506 0.00112658065670329 1.40079426707785 0.857142857142857 18.4 18 4 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.014123759670687 0.0307781164033501 1.40079426707785 0.857142857142857 18.4 18 4 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.014123759670687 0.0307781164033501 1.40079426707785 0.857142857142857 18.4 18 4 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.014123759670687 0.0307781164033501 1.40079426707785 0.857142857142857 18.4 18 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.014123759670687 0.0307781164033501 1.40079426707785 0.857142857142857 18.4 18 4 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.014123759670687 0.0307781164033501 1.40079426707785 0.857142857142857 18.4 18 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.53435062993731e-16 1.15221088328586e-14 1.39741070604626 0.855072463768116 18.4 18 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.58752098237305e-11 1.54728928624441e-10 1.39593039809494 0.854166666666667 18.4 18 4 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 2.11961484594628e-05 8.89738031204001e-05 1.38912098151887 0.85 18.4 18 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 2.11961484594628e-05 8.89738031204001e-05 1.38912098151887 0.85 18.4 18 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 2.11961484594628e-05 8.89738031204001e-05 1.38912098151887 0.85 18.4 18 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.36216455224128e-06 6.84932917964429e-06 1.38283536621788 0.846153846153846 18.4 18 4 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.000782211842099523 0.00237332079170069 1.38283536621788 0.846153846153846 18.4 18 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.81275871619458e-10 1.5539491886415e-09 1.38004175941744 0.844444444444444 18.4 18 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 4.77847950192744e-05 0.000182299633545382 1.37621892905894 0.842105263157895 18.4 18 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.05139200751852e-10 3.23883754308924e-09 1.37426407262562 0.840909090909091 18.4 18 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.13573865994445e-11 5.56124593191143e-10 1.36744202262362 0.836734693877551 18.4 18 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.99554513452185e-14 3.78621430189946e-13 1.36594863854358 0.835820895522388 18.4 18 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 6.39453499729839e-13 8.42539194551445e-12 1.36188331521458 0.833333333333333 18.4 18 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 6.39453499729839e-13 8.42539194551445e-12 1.36188331521458 0.833333333333333 18.4 18 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 6.39453499729839e-13 8.42539194551445e-12 1.36188331521458 0.833333333333333 18.4 18 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 6.39453499729839e-13 8.42539194551445e-12 1.36188331521458 0.833333333333333 18.4 18 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 6.39453499729839e-13 8.42539194551445e-12 1.36188331521458 0.833333333333333 18.4 18 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 6.39453499729839e-13 8.42539194551445e-12 1.36188331521458 0.833333333333333 18.4 18 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 6.39453499729839e-13 8.42539194551445e-12 1.36188331521458 0.833333333333333 18.4 18 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.96513776612205e-08 1.97167805663163e-07 1.36188331521458 0.833333333333333 18.4 18 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000106802741171504 0.000383788638098613 1.36188331521458 0.833333333333333 18.4 18 4 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000106802741171504 0.000383788638098613 1.36188331521458 0.833333333333333 18.4 18 4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0017602683757222 0.0047350886552981 1.36188331521458 0.833333333333333 18.4 18 4 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0323247094171798 0.0637444245974617 1.36188331521458 0.833333333333333 18.4 18 4 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0323247094171798 0.0637444245974617 1.36188331521458 0.833333333333333 18.4 18 4 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0323247094171798 0.0637444245974617 1.36188331521458 0.833333333333333 18.4 18 4 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 48%5605140 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS 0.0323247094171798 0.0637444245974617 1.36188331521458 0.833333333333333 18.4 18 4 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0323247094171798 0.0637444245974617 1.36188331521458 0.833333333333333 18.4 18 4 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0323247094171798 0.0637444245974617 1.36188331521458 0.833333333333333 18.4 18 4 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0323247094171798 0.0637444245974617 1.36188331521458 0.833333333333333 18.4 18 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 6.54471100131733e-08 4.01427748054938e-07 1.35410112484192 0.828571428571429 18.4 18 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 6.54471100131733e-08 4.01427748054938e-07 1.35410112484192 0.828571428571429 18.4 18 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.25860384499404e-15 5.02186448660394e-14 1.35098824869286 0.826666666666667 18.4 18 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.25860384499404e-15 5.02186448660394e-14 1.35098824869286 0.826666666666667 18.4 18 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.25860384499404e-15 5.02186448660394e-14 1.35098824869286 0.826666666666667 18.4 18 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.25860384499404e-15 5.02186448660394e-14 1.35098824869286 0.826666666666667 18.4 18 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.25860384499404e-15 5.02186448660394e-14 1.35098824869286 0.826666666666667 18.4 18 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 9.68468312192138e-09 6.788819745071e-08 1.34826448206243 0.825 18.4 18 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 1.43666933551993e-07 8.37860846083959e-07 1.34586115856499 0.823529411764706 18.4 18 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000236432099732703 0.000795373233852567 1.34586115856499 0.823529411764706 18.4 18 4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000236432099732703 0.000795373233852567 1.34586115856499 0.823529411764706 18.4 18 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 2.15710627508932e-06 1.05483238125502e-05 1.34242783928294 0.821428571428571 18.4 18 4 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00390805589924205 0.00967158877325469 1.33712180039249 0.818181818181818 18.4 18 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 4.67147901869794e-10 3.71369533162412e-09 1.33408977816938 0.816326530612245 18.4 18 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 4.6003958790927e-08 2.9488123134905e-07 1.33321208752585 0.815789473684211 18.4 18 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.69957987055645e-06 2.2144046873516e-05 1.33161924154314 0.814814814814815 18.4 18 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.93929266167027e-29 3.48551121463066e-27 1.32783623233421 0.8125 18.4 18 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000517791909752063 0.00162294688893653 1.32783623233421 0.8125 18.4 18 4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000517791909752063 0.00162294688893653 1.32783623233421 0.8125 18.4 18 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000517791909752063 0.00162294688893653 1.32783623233421 0.8125 18.4 18 4 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000517791909752063 0.00162294688893653 1.32783623233421 0.8125 18.4 18 4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.000517791909752063 0.00162294688893653 1.32783623233421 0.8125 18.4 18 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.81336585217065e-16 1.15221088328586e-14 1.32663457058549 0.811764705882353 18.4 18 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 7.16301934176235e-05 0.000264066749309011 1.3229723633513 0.80952380952381 18.4 18 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.01613948905976e-05 4.50456851380697e-05 1.31997921320798 0.807692307692308 18.4 18 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.13743715471264e-07 1.19746971305358e-06 1.31648720470743 0.805555555555556 18.4 18 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 6.92681791584646e-10 5.32803345635109e-09 1.31381684526583 0.803921568627451 18.4 18 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.57277216478534e-15 5.3839041036611e-14 1.30740798260599 0.8 18.4 18 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.57277216478534e-15 5.3839041036611e-14 1.30740798260599 0.8 18.4 18 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.57277216478534e-15 5.3839041036611e-14 1.30740798260599 0.8 18.4 18 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.17914986169113e-05 9.04061298305094e-05 1.30740798260599 0.8 18.4 18 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.17914986169113e-05 9.04061298305094e-05 1.30740798260599 0.8 18.4 18 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 2.17914986169113e-05 9.04061298305094e-05 1.30740798260599 0.8 18.4 18 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 2.17914986169113e-05 9.04061298305094e-05 1.30740798260599 0.8 18.4 18 4 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.000154139381258521 0.000536284448730745 1.30740798260599 0.8 18.4 18 4 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00853856564400548 0.0195343712402248 1.30740798260599 0.8 18.4 18 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00853856564400548 0.0195343712402248 1.30740798260599 0.8 18.4 18 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00112027388596735 0.0032335694517881 1.30740798260599 0.8 18.4 18 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00112027388596735 0.0032335694517881 1.30740798260599 0.8 18.4 18 4 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00112027388596735 0.0032335694517881 1.30740798260599 0.8 18.4 18 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00112027388596735 0.0032335694517881 1.30740798260599 0.8 18.4 18 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00112027388596735 0.0032335694517881 1.30740798260599 0.8 18.4 18 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00112027388596735 0.0032335694517881 1.30740798260599 0.8 18.4 18 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.64439077865231e-16 9.17797092200547e-15 1.30037890743069 0.795698924731183 18.4 18 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.04169717577679e-28 2.23487313933106e-26 1.29779468861624 0.794117647058823 18.4 18 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 9.68776207454606e-07 4.88854093336136e-06 1.29779468861624 0.794117647058823 18.4 18 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 9.68776207454606e-07 4.88854093336136e-06 1.29779468861624 0.794117647058823 18.4 18 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 9.68776207454606e-07 4.88854093336136e-06 1.29779468861624 0.794117647058823 18.4 18 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 2.21642333505576e-11 2.13106108498942e-10 1.29703172877579 0.793650793650794 18.4 18 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.47527473760676e-10 1.28792389669596e-09 1.29613722413525 0.793103448275862 18.4 18 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.47527473760676e-10 1.28792389669596e-09 1.29613722413525 0.793103448275862 18.4 18 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 6.65719052894965e-06 3.01693698175011e-05 1.29613722413525 0.793103448275862 18.4 18 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 6.65719052894965e-06 3.01693698175011e-05 1.29613722413525 0.793103448275862 18.4 18 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.30031507090309e-28 4.37096310421079e-26 1.29580376974263 0.792899408284024 18.4 18 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 7.05497494944505e-22 4.36488232741752e-20 1.29483675200401 0.792307692307692 18.4 18 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 4.6318997565091e-05 0.000178015645816397 1.29378914945385 0.791666666666667 18.4 18 4 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 4.6318997565091e-05 0.000178015645816397 1.29378914945385 0.791666666666667 18.4 18 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 4.6318997565091e-05 0.000178015645816397 1.29378914945385 0.791666666666667 18.4 18 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.09017492133845e-14 8.72689025670435e-13 1.29126714331456 0.790123456790123 18.4 18 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.09017492133845e-14 8.72689025670435e-13 1.29126714331456 0.790123456790123 18.4 18 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000328120039242367 0.00108332903907631 1.29020524599276 0.789473684210526 18.4 18 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000328120039242367 0.00108332903907631 1.29020524599276 0.789473684210526 18.4 18 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.18650615722851e-16 4.22099565434043e-15 1.28759877074833 0.787878787878788 18.4 18 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 9.75559124064158e-11 8.73094738077545e-10 1.28597506485836 0.786885245901639 18.4 18 4 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00239047277189159 0.0062415463383518 1.28406141148803 0.785714285714286 18.4 18 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00239047277189159 0.0062415463383518 1.28406141148803 0.785714285714286 18.4 18 4 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00239047277189159 0.0062415463383518 1.28406141148803 0.785714285714286 18.4 18 4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.00239047277189159 0.0062415463383518 1.28406141148803 0.785714285714286 18.4 18 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.63073835929166e-26 3.03914157957178e-24 1.28334525899975 0.785276073619632 18.4 18 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.19836579708715e-17 5.50088557824198e-16 1.28297045022084 0.785046728971963 18.4 18 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.22191629897369e-13 3.29352801399954e-12 1.28258378040461 0.784810126582278 18.4 18 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.22191629897369e-13 3.29352801399954e-12 1.28258378040461 0.784810126582278 18.4 18 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.22191629897369e-13 3.29352801399954e-12 1.28258378040461 0.784810126582278 18.4 18 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.32054220891792e-09 3.16913998107742e-08 1.28177253196666 0.784313725490196 18.4 18 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.32054220891792e-09 3.16913998107742e-08 1.28177253196666 0.784313725490196 18.4 18 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 4.32054220891792e-09 3.16913998107742e-08 1.28177253196666 0.784313725490196 18.4 18 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.09297868338633e-22 1.48915433322937e-20 1.28154199733861 0.784172661870504 18.4 18 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 9.66117478936867e-12 9.54711925366085e-11 1.27898606994065 0.782608695652174 18.4 18 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 9.66117478936867e-12 9.54711925366085e-11 1.27898606994065 0.782608695652174 18.4 18 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.88792870089522e-08 1.92935330580934e-07 1.27898606994065 0.782608695652174 18.4 18 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 2.88792870089522e-08 1.92935330580934e-07 1.27898606994065 0.782608695652174 18.4 18 4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 9.75053702728504e-05 0.000352157720553975 1.27898606994065 0.782608695652174 18.4 18 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 9.75053702728504e-05 0.000352157720553975 1.27898606994065 0.782608695652174 18.4 18 4 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 9.75053702728504e-05 0.000352157720553975 1.27898606994065 0.782608695652174 18.4 18 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.04042876750699e-12 3.82878773111721e-11 1.27606601042023 0.780821917808219 18.4 18 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.28934004034928e-12 6.53265027548688e-11 1.27109109420027 0.777777777777778 18.4 18 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 2.92777474607418e-05 0.00011995977719572 1.27109109420027 0.777777777777778 18.4 18 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000690134854696898 0.00211196107147029 1.27109109420027 0.777777777777778 18.4 18 4 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.000690134854696898 0.00211196107147029 1.27109109420027 0.777777777777778 18.4 18 4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000690134854696898 0.00211196107147029 1.27109109420027 0.777777777777778 18.4 18 4 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0182993679116712 0.0387004818649389 1.27109109420027 0.777777777777778 18.4 18 4 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0182993679116712 0.0387004818649389 1.27109109420027 0.777777777777778 18.4 18 4 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0182993679116712 0.0387004818649389 1.27109109420027 0.777777777777778 18.4 18 4 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0182993679116712 0.0387004818649389 1.27109109420027 0.777777777777778 18.4 18 4 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0182993679116712 0.0387004818649389 1.27109109420027 0.777777777777778 18.4 18 4 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0182993679116712 0.0387004818649389 1.27109109420027 0.777777777777778 18.4 18 4 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0182993679116712 0.0387004818649389 1.27109109420027 0.777777777777778 18.4 18 4 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0182993679116712 0.0387004818649389 1.27109109420027 0.777777777777778 18.4 18 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 9.48129494849496e-14 1.56882357112888e-12 1.26895480664699 0.776470588235294 18.4 18 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 4.13653267152323e-11 3.82226363089452e-10 1.26838087864761 0.776119402985075 18.4 18 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 6.20607262073411e-13 8.42539194551445e-12 1.26655148314956 0.775 18.4 18 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.72277768243603e-10 2.26579686672893e-09 1.26523353155419 0.774193548387097 18.4 18 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 8.86006894257253e-06 3.97724861365322e-05 1.26523353155419 0.774193548387097 18.4 18 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000203098775278828 0.00069141042397553 1.26283725592624 0.772727272727273 18.4 18 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.18021883643554e-19 1.1932505400953e-17 1.26108250290736 0.771653543307087 18.4 18 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.66019196278682e-11 2.52363544203043e-10 1.26071484037007 0.771428571428571 18.4 18 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 5.58674001738084e-10 4.32061469822442e-09 1.25918391767381 0.770491803278688 18.4 18 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.58674001738084e-10 4.32061469822442e-09 1.25918391767381 0.770491803278688 18.4 18 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.25509569408627e-13 2.00674289065704e-12 1.25856802923278 0.770114942528736 18.4 18 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.25509569408627e-13 2.00674289065704e-12 1.25856802923278 0.770114942528736 18.4 18 4 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00502045682113114 0.0120474031306402 1.25712306019807 0.769230769230769 18.4 18 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 8.16858516043879e-13 1.0664125397527e-11 1.25558998329539 0.768292682926829 18.4 18 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.69916359979476e-11 1.64483660034554e-10 1.25367888743041 0.767123287671233 18.4 18 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.8229784077663e-05 7.83715490710408e-05 1.25293264999741 0.766666666666667 18.4 18 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 7.81062172642771e-08 4.70954013419773e-07 1.25177360036744 0.765957446808511 18.4 18 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.81062172642771e-08 4.70954013419773e-07 1.25177360036744 0.765957446808511 18.4 18 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00143221129231498 0.00394204384712614 1.24972821866749 0.764705882352941 18.4 18 4 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.00143221129231498 0.00394204384712614 1.24972821866749 0.764705882352941 18.4 18 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00143221129231498 0.00394204384712614 1.24972821866749 0.764705882352941 18.4 18 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00143221129231498 0.00394204384712614 1.24972821866749 0.764705882352941 18.4 18 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00143221129231498 0.00394204384712614 1.24972821866749 0.764705882352941 18.4 18 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 3.45428004440472e-11 3.25525861138273e-10 1.2483930389467 0.763888888888889 18.4 18 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.29172767416608e-29 1.67102589121666e-27 1.24515045962476 0.761904761904762 18.4 18 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.20832696013176e-10 5.51475766896102e-09 1.24515045962476 0.761904761904762 18.4 18 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000418168782349391 0.00135857118101183 1.24515045962476 0.761904761904762 18.4 18 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000418168782349391 0.00135857118101183 1.24515045962476 0.761904761904762 18.4 18 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000418168782349391 0.00135857118101183 1.24515045962476 0.761904761904762 18.4 18 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000418168782349391 0.00135857118101183 1.24515045962476 0.761904761904762 18.4 18 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000123989410900994 0.000442197823839887 1.2420375834757 0.76 18.4 18 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.5631722610939e-36 1.53748487536237e-33 1.23978343178155 0.758620689655172 18.4 18 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 3.71684738467495e-05 0.000145304226054738 1.23978343178155 0.758620689655172 18.4 18 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 6.22892448982237e-17 2.33256830237296e-15 1.23599494153928 0.756302521008403 18.4 18 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.33992277985877e-12 1.71775686102615e-11 1.23519649519462 0.755813953488372 18.4 18 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.82979043914281e-10 2.34115802029083e-09 1.2316162154984 0.753623188405797 18.4 18 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.66028965399247e-56 1.30214804440782e-53 1.23144942023628 0.753521126760563 18.4 18 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.53481878437528e-15 5.3839041036611e-14 1.22944328639555 0.752293577981651 18.4 18 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.82387583761904e-38 4.32562552821983e-36 1.22708940346979 0.750853242320819 18.4 18 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.76108142492007e-10 1.5187993137341e-09 1.22569498369312 0.75 18.4 18 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.09740215513939e-06 1.02917354026322e-05 1.22569498369312 0.75 18.4 18 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000850062013193908 0.00255737472468273 1.22569498369312 0.75 18.4 18 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000850062013193908 0.00255737472468273 1.22569498369312 0.75 18.4 18 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000850062013193908 0.00255737472468273 1.22569498369312 0.75 18.4 18 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000850062013193908 0.00255737472468273 1.22569498369312 0.75 18.4 18 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.81780671703492e-09 1.36144155702142e-08 1.22569498369312 0.75 18.4 18 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.88824731050232e-08 1.31071996236332e-07 1.22569498369312 0.75 18.4 18 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 7.50450406811592e-05 0.000275229620848685 1.22569498369312 0.75 18.4 18 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000251064488396127 0.000840622981147503 1.22569498369312 0.75 18.4 18 4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000251064488396127 0.000840622981147503 1.22569498369312 0.75 18.4 18 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0029277198146132 0.00745285383934631 1.22569498369312 0.75 18.4 18 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0029277198146132 0.00745285383934631 1.22569498369312 0.75 18.4 18 4 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0029277198146132 0.00745285383934631 1.22569498369312 0.75 18.4 18 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0029277198146132 0.00745285383934631 1.22569498369312 0.75 18.4 18 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0029277198146132 0.00745285383934631 1.22569498369312 0.75 18.4 18 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0029277198146132 0.00745285383934631 1.22569498369312 0.75 18.4 18 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0029277198146132 0.00745285383934631 1.22569498369312 0.75 18.4 18 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0029277198146132 0.00745285383934631 1.22569498369312 0.75 18.4 18 4 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0103514184698016 0.0233810610833773 1.22569498369312 0.75 18.4 18 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0103514184698016 0.0233810610833773 1.22569498369312 0.75 18.4 18 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0103514184698016 0.0233810610833773 1.22569498369312 0.75 18.4 18 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0103514184698016 0.0233810610833773 1.22569498369312 0.75 18.4 18 4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0103514184698016 0.0233810610833773 1.22569498369312 0.75 18.4 18 4 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0103514184698016 0.0233810610833773 1.22569498369312 0.75 18.4 18 4 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0383019856724886 0.0736536832593936 1.22569498369312 0.75 18.4 18 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.09191700996859e-10 9.71123690740818e-10 1.22024745043226 0.746666666666667 18.4 18 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 3.50192119836128e-10 2.84756220872463e-09 1.21994054714996 0.746478873239437 18.4 18 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.50192119836128e-10 2.84756220872463e-09 1.21994054714996 0.746478873239437 18.4 18 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.12447579095096e-09 8.51132473682562e-09 1.21959699869962 0.746268656716418 18.4 18 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.75743624260365e-08 2.45267512533257e-07 1.2182665292465 0.745454545454545 18.4 18 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.75743624260365e-08 2.45267512533257e-07 1.2182665292465 0.745454545454545 18.4 18 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.75743624260365e-08 2.45267512533257e-07 1.2182665292465 0.745454545454545 18.4 18 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.02482491232935e-13 3.16629214312601e-12 1.21735692257956 0.744897959183674 18.4 18 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.16166016537565e-10 1.83097762817235e-09 1.21465268654273 0.743243243243243 18.4 18 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.16166016537565e-10 1.83097762817235e-09 1.21465268654273 0.743243243243243 18.4 18 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.15521320513105e-09 5.14235777318257e-08 1.21251546773943 0.741935483870968 18.4 18 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.30412059043526e-08 1.5763286539372e-07 1.21160653560469 0.741379310344828 18.4 18 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 7.4334689828987e-08 4.52043861652344e-07 1.2105629468574 0.740740740740741 18.4 18 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 7.4334689828987e-08 4.52043861652344e-07 1.2105629468574 0.740740740740741 18.4 18 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000149932121258571 0.00052429206220502 1.2105629468574 0.740740740740741 18.4 18 4 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000149932121258571 0.00052429206220502 1.2105629468574 0.740740740740741 18.4 18 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 7.74346277699596e-14 1.29634676843121e-12 1.20998094544064 0.740384615384615 18.4 18 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.46751964792235e-13 3.58293924387092e-12 1.20935238391055 0.74 18.4 18 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.46751964792235e-13 3.58293924387092e-12 1.20935238391055 0.74 18.4 18 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 7.79006151052657e-07 4.07546232701445e-06 1.20793128827728 0.739130434782609 18.4 18 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00050228008946243 0.00159185872451011 1.20793128827728 0.739130434782609 18.4 18 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00050228008946243 0.00159185872451011 1.20793128827728 0.739130434782609 18.4 18 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 5.57067007355241e-17 2.26380211825902e-15 1.20419156292657 0.736842105263158 18.4 18 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.61160553272237e-10 2.18606745474349e-09 1.20419156292657 0.736842105263158 18.4 18 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.61160553272237e-10 2.18606745474349e-09 1.20419156292657 0.736842105263158 18.4 18 4 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00170377633796958 0.00466244947871292 1.20419156292657 0.736842105263158 18.4 18 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.83651081324614e-27 2.69090325816617e-25 1.20187729342704 0.73542600896861 18.4 18 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.59727449446496e-10 1.3859278083071e-09 1.19983643973335 0.734177215189873 18.4 18 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 5.02318253018189e-62 2.38266291348294e-59 1.19928583955778 0.733840304182509 18.4 18 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 9.59623888571729e-12 9.54711925366085e-11 1.19845731738883 0.733333333333333 18.4 18 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.75720915491441e-08 1.85948276182142e-07 1.19845731738883 0.733333333333333 18.4 18 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00588351970818327 0.0140473968871557 1.19845731738883 0.733333333333333 18.4 18 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00588351970818327 0.0140473968871557 1.19845731738883 0.733333333333333 18.4 18 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 4.96927205846296e-06 2.28843823274848e-05 1.19579998409085 0.731707317073171 18.4 18 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 4.96927205846296e-06 2.28843823274848e-05 1.19579998409085 0.731707317073171 18.4 18 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 4.96927205846296e-06 2.28843823274848e-05 1.19579998409085 0.731707317073171 18.4 18 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 4.96927205846296e-06 2.28843823274848e-05 1.19579998409085 0.731707317073171 18.4 18 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 4.96927205846296e-06 2.28843823274848e-05 1.19579998409085 0.731707317073171 18.4 18 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000296158996243525 0.000982364222970947 1.19426690718817 0.730769230769231 18.4 18 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000296158996243525 0.000982364222970947 1.19426690718817 0.730769230769231 18.4 18 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.61983247845803e-05 7.00614473205403e-05 1.19256809224195 0.72972972972973 18.4 18 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.61983247845803e-05 7.00614473205403e-05 1.19256809224195 0.72972972972973 18.4 18 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.16302263522297e-13 3.29352801399954e-12 1.19132970377649 0.728971962616822 18.4 18 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 8.00700358705372e-15 1.5397251492402e-13 1.18855271146 0.727272727272727 18.4 18 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 8.00700358705372e-15 1.5397251492402e-13 1.18855271146 0.727272727272727 18.4 18 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.72362229570188e-07 9.85025914370995e-07 1.18855271146 0.727272727272727 18.4 18 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.72362229570188e-07 9.85025914370995e-07 1.18855271146 0.727272727272727 18.4 18 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.72362229570188e-07 9.85025914370995e-07 1.18855271146 0.727272727272727 18.4 18 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 5.30239924743789e-05 0.000201746367088345 1.18855271146 0.727272727272727 18.4 18 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00099168880120423 0.00293994409190337 1.18855271146 0.727272727272727 18.4 18 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00099168880120423 0.00293994409190337 1.18855271146 0.727272727272727 18.4 18 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00099168880120423 0.00293994409190337 1.18855271146 0.727272727272727 18.4 18 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00099168880120423 0.00293994409190337 1.18855271146 0.727272727272727 18.4 18 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0208865916300413 0.0430124745145423 1.18855271146 0.727272727272727 18.4 18 4 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0208865916300413 0.0430124745145423 1.18855271146 0.727272727272727 18.4 18 4 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0208865916300413 0.0430124745145423 1.18855271146 0.727272727272727 18.4 18 4 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0208865916300413 0.0430124745145423 1.18855271146 0.727272727272727 18.4 18 4 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0208865916300413 0.0430124745145423 1.18855271146 0.727272727272727 18.4 18 4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0208865916300413 0.0430124745145423 1.18855271146 0.727272727272727 18.4 18 4 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0208865916300413 0.0430124745145423 1.18855271146 0.727272727272727 18.4 18 4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0208865916300413 0.0430124745145423 1.18855271146 0.727272727272727 18.4 18 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.3031768059762e-21 7.72675247876723e-20 1.18774085851501 0.726775956284153 18.4 18 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 9.6707883956418e-06 4.30047871468696e-05 1.18483848423668 0.725 18.4 18 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 5.62036532284337e-31 7.99777985440612e-29 1.18363682248796 0.724264705882353 18.4 18 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.03846670323701e-07 6.13169343861521e-07 1.18342963942784 0.724137931034483 18.4 18 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.32936821695527e-07 1.81520726924419e-06 1.18029887318597 0.722222222222222 18.4 18 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00336161003012199 0.00849657384167601 1.18029887318597 0.722222222222222 18.4 18 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 5.76652083424685e-06 2.64701907972041e-05 1.17818742618563 0.720930232558139 18.4 18 4 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.000577828973383608 0.00179530705049099 1.1766671843454 0.72 18.4 18 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000577828973383608 0.00179530705049099 1.1766671843454 0.72 18.4 18 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 5.66268374441115e-13 8.13939289726977e-12 1.17369580256675 0.718181818181818 18.4 18 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 1.86588802390272e-05 7.99746583739025e-05 1.17331485618487 0.717948717948718 18.4 18 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.0860615162705e-14 3.80572504827298e-13 1.17297691987836 0.717741935483871 18.4 18 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.0860615162705e-14 3.80572504827298e-13 1.17297691987836 0.717741935483871 18.4 18 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.0860615162705e-14 3.80572504827298e-13 1.17297691987836 0.717741935483871 18.4 18 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 3.43548510186007e-06 1.65158624998206e-05 1.17240389744559 0.717391304347826 18.4 18 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 3.43548510186007e-06 1.65158624998206e-05 1.17240389744559 0.717391304347826 18.4 18 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 6.3884976154801e-07 3.39210153239857e-06 1.17173356931669 0.716981132075472 18.4 18 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.19676541409346e-07 7.03717844733469e-07 1.17121965108454 0.716666666666667 18.4 18 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 6.05356156040218e-05 0.000226689950011903 1.16732855589821 0.714285714285714 18.4 18 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 6.05356156040218e-05 0.000226689950011903 1.16732855589821 0.714285714285714 18.4 18 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.87359931267822e-10 3.8315645425089e-09 1.16732855589821 0.714285714285714 18.4 18 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.87359931267822e-10 3.8315645425089e-09 1.16732855589821 0.714285714285714 18.4 18 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.10608251481954e-05 4.88806030617455e-05 1.16732855589821 0.714285714285714 18.4 18 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0003371498227021 0.00110800045659374 1.16732855589821 0.714285714285714 18.4 18 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0019297950903052 0.00515215462195928 1.16732855589821 0.714285714285714 18.4 18 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0019297950903052 0.00515215462195928 1.16732855589821 0.714285714285714 18.4 18 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.01159541694423 0.0259031056697634 1.16732855589821 0.714285714285714 18.4 18 4 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.01159541694423 0.0259031056697634 1.16732855589821 0.714285714285714 18.4 18 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.01159541694423 0.0259031056697634 1.16732855589821 0.714285714285714 18.4 18 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.01159541694423 0.0259031056697634 1.16732855589821 0.714285714285714 18.4 18 4 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0778270837834116 0.132190884386118 1.16732855589821 0.714285714285714 18.4 18 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 7.24035574178053e-24 5.42264537923879e-22 1.16626734812012 0.713636363636364 18.4 18 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.10959372759407e-09 5.7128474625576e-08 1.16413039547109 0.712328767123288 18.4 18 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 6.55578108045423e-06 2.99002451201486e-05 1.16214042898311 0.711111111111111 18.4 18 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.17524074188149e-16 4.22099565434043e-15 1.16118472139348 0.710526315789474 18.4 18 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.56493368869622e-08 1.73804792334034e-07 1.16056143383503 0.710144927536232 18.4 18 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000197006251117869 0.000672277926476565 1.15979740392467 0.709677419354839 18.4 18 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 4.26701429417733e-17 1.83998828503465e-15 1.15846276939772 0.708860759493671 18.4 18 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 3.88559161361675e-06 1.86168244652412e-05 1.15760081793239 0.708333333333333 18.4 18 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00111237512062345 0.0032335694517881 1.15760081793239 0.708333333333333 18.4 18 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00111237512062345 0.0032335694517881 1.15760081793239 0.708333333333333 18.4 18 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00111237512062345 0.0032335694517881 1.15760081793239 0.708333333333333 18.4 18 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 8.1098619545238e-08 4.86933905539551e-07 1.15655321538223 0.707692307692308 18.4 18 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.10327862104907e-05 8.89738031204001e-05 1.15593998462115 0.707317073170732 18.4 18 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.10327862104907e-05 8.89738031204001e-05 1.15593998462115 0.707317073170732 18.4 18 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.59294693935234e-15 7.40980216622954e-14 1.15565527033923 0.707142857142857 18.4 18 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.80614987962292e-11 3.53996815601531e-10 1.15553735836388 0.707070707070707 18.4 18 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00011528100100057 0.000412173026190482 1.15359527877 0.705882352941177 18.4 18 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00011528100100057 0.000412173026190482 1.15359527877 0.705882352941177 18.4 18 4 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00651694026812893 0.0153282743827231 1.15359527877 0.705882352941177 18.4 18 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00651694026812893 0.0153282743827231 1.15359527877 0.705882352941177 18.4 18 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.73869860212467e-15 1.33182890428103e-13 1.15221207100169 0.705035971223022 18.4 18 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000643447824332788 0.00198187500871333 1.15003479951453 0.703703703703704 18.4 18 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000643447824332788 0.00198187500871333 1.15003479951453 0.703703703703704 18.4 18 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000643447824332788 0.00198187500871333 1.15003479951453 0.703703703703704 18.4 18 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000643447824332788 0.00198187500871333 1.15003479951453 0.703703703703704 18.4 18 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.94281919025086e-12 3.73895688189909e-11 1.14684910754912 0.701754385964912 18.4 18 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 9.06783512645038e-08 5.39896626984891e-07 1.14642117877764 0.701492537313433 18.4 18 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 9.06783512645038e-08 5.39896626984891e-07 1.14642117877764 0.701492537313433 18.4 18 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 3.96310945402598e-05 0.00015450697953641 1.14398198478025 0.7 18.4 18 4 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00369577642911284 0.00932462740891415 1.14398198478025 0.7 18.4 18 4 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0410745732028912 0.0771096539151902 1.14398198478025 0.7 18.4 18 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.50527842314861e-16 1.15221088328586e-14 1.14089847538731 0.69811320754717 18.4 18 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.5552694964706e-06 1.23678520186315e-05 1.14089847538731 0.69811320754717 18.4 18 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.32784504880767e-05 9.60151740421249e-05 1.14018138017965 0.697674418604651 18.4 18 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.32784504880767e-05 9.60151740421249e-05 1.14018138017965 0.697674418604651 18.4 18 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.9085593521199e-08 1.31838832915855e-07 1.13968130062694 0.697368421052632 18.4 18 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000217158747508308 0.000734006882908128 1.13902968181583 0.696969696969697 18.4 18 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000217158747508308 0.000734006882908128 1.13902968181583 0.696969696969697 18.4 18 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 8.93474477382871e-07 4.57343230689146e-06 1.13567218828063 0.694915254237288 18.4 18 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 8.93474477382871e-07 4.57343230689146e-06 1.13567218828063 0.694915254237288 18.4 18 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 8.93474477382871e-07 4.57343230689146e-06 1.13567218828063 0.694915254237288 18.4 18 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 8.93474477382871e-07 4.57343230689146e-06 1.13567218828063 0.694915254237288 18.4 18 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.95333106567142e-08 3.69938432596089e-07 1.13490276267881 0.694444444444444 18.4 18 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000126605328318669 0.000450398455493664 1.13490276267881 0.694444444444444 18.4 18 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.19896875609138e-15 2.89175006765768e-14 1.13461361547813 0.694267515923567 18.4 18 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 5.33521382578544e-14 9.03810627868176e-13 1.13230869922126 0.692857142857143 18.4 18 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 7.39575715157581e-05 0.000271942181568278 1.13141075417826 0.692307692307692 18.4 18 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 4.74617222416629e-06 2.22164574835152e-05 1.13141075417826 0.692307692307692 18.4 18 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 4.74617222416629e-06 2.22164574835152e-05 1.13141075417826 0.692307692307692 18.4 18 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0012115864219488 0.00344129237212204 1.13141075417826 0.692307692307692 18.4 18 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0012115864219488 0.00344129237212204 1.13141075417826 0.692307692307692 18.4 18 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0012115864219488 0.00344129237212204 1.13141075417826 0.692307692307692 18.4 18 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0223460821793101 0.0456219152670851 1.13141075417826 0.692307692307692 18.4 18 4 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0223460821793101 0.0456219152670851 1.13141075417826 0.692307692307692 18.4 18 4 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0223460821793101 0.0456219152670851 1.13141075417826 0.692307692307692 18.4 18 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.63351178459402e-20 3.20659490779091e-18 1.12841760403494 0.69047619047619 18.4 18 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 4.3277930118688e-05 0.000167805162285812 1.12841760403494 0.69047619047619 18.4 18 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 4.3277930118688e-05 0.000167805162285812 1.12841760403494 0.69047619047619 18.4 18 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.16730569151805e-17 5.50088557824198e-16 1.12799465890599 0.690217391304348 18.4 18 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 8.46486832408506e-13 1.095046147743e-11 1.12751269817765 0.689922480620155 18.4 18 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 6.97326226694875e-18 3.54391150209574e-16 1.1273772042525 0.689839572192513 18.4 18 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000698658253992359 0.00213345642796379 1.12707584707413 0.689655172413793 18.4 18 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.13795222838482e-17 9.50720631559873e-16 1.12522818175106 0.688524590163934 18.4 18 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.77210003555344e-11 3.53138049381088e-10 1.12355373505203 0.6875 18.4 18 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 5.76025256146735e-07 3.06997730148616e-06 1.12355373505203 0.6875 18.4 18 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.76025256146735e-07 3.06997730148616e-06 1.12355373505203 0.6875 18.4 18 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 1.4885403717977e-05 6.51751676636346e-05 1.12355373505203 0.6875 18.4 18 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 4.78481225825645e-09 3.47387134872395e-08 1.12011077161469 0.685393258426966 18.4 18 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.15674642043201e-10 1.02239140141289e-09 1.1197707258431 0.685185185185185 18.4 18 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000136613931799897 0.000484792082172701 1.11817787986039 0.684210526315789 18.4 18 4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00695358302978552 0.0162745865976724 1.11817787986039 0.684210526315789 18.4 18 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 7.96889894043777e-05 0.000290762645954947 1.11607998515146 0.682926829268293 18.4 18 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 8.63086448591913e-12 8.7104398322432e-11 1.11607998515146 0.682926829268293 18.4 18 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 8.63086448591913e-12 8.7104398322432e-11 1.11607998515146 0.682926829268293 18.4 18 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 4.65739605975569e-05 0.000178157919167536 1.11426816699375 0.681818181818182 18.4 18 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.59866642034994e-05 6.95688781699684e-05 1.1112967852151 0.68 18.4 18 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.59866642034994e-05 6.95688781699684e-05 1.1112967852151 0.68 18.4 18 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00224828568350812 0.00596886292468667 1.1112967852151 0.68 18.4 18 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.87850095110764e-14 5.18494538408377e-13 1.11045870317496 0.67948717948718 18.4 18 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00129007693888646 0.00363520689908006 1.1089621281033 0.678571428571429 18.4 18 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00129007693888646 0.00363520689908006 1.1089621281033 0.678571428571429 18.4 18 4 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00129007693888646 0.00363520689908006 1.1089621281033 0.678571428571429 18.4 18 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 7.65651705544376e-16 1.9114427666485e-14 1.10797286661525 0.677966101694915 18.4 18 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000743580103592918 0.00226576978032703 1.10707934010991 0.67741935483871 18.4 18 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 9.98496939420818e-12 9.79904237790223e-11 1.10666423724523 0.677165354330709 18.4 18 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.30532072548317e-14 5.87933924045319e-13 1.10312548532381 0.675 18.4 18 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 8.47054236392401e-05 0.000308275748947925 1.10217533417366 0.674418604651163 18.4 18 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.34319364890867e-12 6.54084388579495e-11 1.1018874095827 0.674242424242424 18.4 18 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.96497760068241e-72 2.82108156288554e-69 1.10183138805596 0.67420814479638 18.4 18 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.84293931052968e-22 4.36488232741752e-20 1.09998267767331 0.673076923076923 18.4 18 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.69824980731311e-05 7.32305901759561e-05 1.09998267767331 0.673076923076923 18.4 18 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 5.090674244956e-08 3.19120240113321e-07 1.0959155148315 0.670588235294118 18.4 18 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 5.090674244956e-08 3.19120240113321e-07 1.0959155148315 0.670588235294118 18.4 18 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 5.090674244956e-08 3.19120240113321e-07 1.0959155148315 0.670588235294118 18.4 18 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 5.090674244956e-08 3.19120240113321e-07 1.0959155148315 0.670588235294118 18.4 18 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 5.090674244956e-08 3.19120240113321e-07 1.0959155148315 0.670588235294118 18.4 18 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.48907998035934e-12 5.55474853221856e-11 1.08950665217166 0.666666666666667 18.4 18 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.53380593990627e-07 8.90859531627194e-07 1.08950665217166 0.666666666666667 18.4 18 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.59455145350208e-07 1.44786145816999e-06 1.08950665217166 0.666666666666667 18.4 18 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000450965778050875 0.00144207708351999 1.08950665217166 0.666666666666667 18.4 18 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000778714655316162 0.00236775844981816 1.08950665217166 0.666666666666667 18.4 18 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00234786361718083 0.00617561908918358 1.08950665217166 0.666666666666667 18.4 18 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00234786361718083 0.00617561908918358 1.08950665217166 0.666666666666667 18.4 18 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00234786361718083 0.00617561908918358 1.08950665217166 0.666666666666667 18.4 18 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00234786361718083 0.00617561908918358 1.08950665217166 0.666666666666667 18.4 18 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00410626161430954 0.0101268808962955 1.08950665217166 0.666666666666667 18.4 18 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0128276007441428 0.0283442171722286 1.08950665217166 0.666666666666667 18.4 18 4 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0419569379505206 0.0775386009137543 1.08950665217166 0.666666666666667 18.4 18 4 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0419569379505206 0.0775386009137543 1.08950665217166 0.666666666666667 18.4 18 4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0419569379505206 0.0775386009137543 1.08950665217166 0.666666666666667 18.4 18 4 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0419569379505206 0.0775386009137543 1.08950665217166 0.666666666666667 18.4 18 4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0419569379505206 0.0775386009137543 1.08950665217166 0.666666666666667 18.4 18 4 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0783072211941236 0.132190884386118 1.08950665217166 0.666666666666667 18.4 18 4 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0783072211941236 0.132190884386118 1.08950665217166 0.666666666666667 18.4 18 4 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0783072211941236 0.132190884386118 1.08950665217166 0.666666666666667 18.4 18 4 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0783072211941236 0.132190884386118 1.08950665217166 0.666666666666667 18.4 18 4 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0783072211941236 0.132190884386118 1.08950665217166 0.666666666666667 18.4 18 4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0783072211941236 0.132190884386118 1.08950665217166 0.666666666666667 18.4 18 4 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0783072211941236 0.132190884386118 1.08950665217166 0.666666666666667 18.4 18 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000152511107975757 0.000531919869238978 1.08950665217166 0.666666666666667 18.4 18 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00134933396782197 0.0037797288114383 1.08950665217166 0.666666666666667 18.4 18 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00134933396782197 0.0037797288114383 1.08950665217166 0.666666666666667 18.4 18 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00722773910672813 0.0168607749981543 1.08950665217166 0.666666666666667 18.4 18 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00722773910672813 0.0168607749981543 1.08950665217166 0.666666666666667 18.4 18 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0230192114163235 0.0467280140448336 1.08950665217166 0.666666666666667 18.4 18 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0230192114163235 0.0467280140448336 1.08950665217166 0.666666666666667 18.4 18 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.24522282624928e-13 2.00674289065704e-12 1.08618498554919 0.664634146341463 18.4 18 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 5.91201091353516e-13 8.41279152996054e-12 1.08599211458401 0.664516129032258 18.4 18 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.33490952638063e-08 2.207244770251e-07 1.08358542036638 0.66304347826087 18.4 18 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.6077157538285e-07 9.29991673860958e-07 1.08294335908629 0.662650602409639 18.4 18 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.2363596213474e-06 1.08984237711553e-05 1.08149557384687 0.661764705882353 18.4 18 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 9.92212394341274e-08 5.8829926547818e-07 1.07712589476062 0.659090909090909 18.4 18 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000158426252186494 0.00054851716997903 1.07712589476062 0.659090909090909 18.4 18 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000158426252186494 0.00054851716997903 1.07712589476062 0.659090909090909 18.4 18 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 2.83263488664114e-07 1.57454665769154e-06 1.07621998568176 0.658536585365854 18.4 18 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00139121256933127 0.00388938209461374 1.07248311073148 0.65625 18.4 18 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 4.96119526110299e-07 2.69457284601128e-06 1.06933060305737 0.654320987654321 18.4 18 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 2.4008475214428e-06 1.16600888157444e-05 1.06680859691809 0.652777777777778 18.4 18 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.31077277828076e-08 3.90444767977979e-07 1.06656967002068 0.652631578947368 18.4 18 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000163055506154071 0.000560371045321997 1.06582172495054 0.652173913043478 18.4 18 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 8.08493121972919e-09 5.7128474625576e-08 1.06451796748883 0.651376146788991 18.4 18 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 3.02906755219575e-07 1.67718409602123e-06 1.06416928816767 0.651162790697674 18.4 18 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000478609962760027 0.00152704479149668 1.06226898586737 0.65 18.4 18 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0130037952881777 0.0286003101933181 1.06226898586737 0.65 18.4 18 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0130037952881777 0.0286003101933181 1.06226898586737 0.65 18.4 18 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.79543943481058e-10 3.05136176030252e-09 1.06039769581593 0.648854961832061 18.4 18 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.79543943481058e-10 3.05136176030252e-09 1.06039769581593 0.648854961832061 18.4 18 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.110962258732e-07 1.71585243960296e-06 1.05855475864406 0.647727272727273 18.4 18 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 5.246523551289e-07 2.82795568692585e-06 1.0574623388725 0.647058823529412 18.4 18 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 5.246523551289e-07 2.82795568692585e-06 1.0574623388725 0.647058823529412 18.4 18 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00141770245801757 0.00394021601124806 1.0574623388725 0.647058823529412 18.4 18 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00141770245801757 0.00394021601124806 1.0574623388725 0.647058823529412 18.4 18 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00141770245801757 0.00394021601124806 1.0574623388725 0.647058823529412 18.4 18 4 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0231467346848697 0.0467866526371726 1.0574623388725 0.647058823529412 18.4 18 4 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0231467346848697 0.0467866526371726 1.0574623388725 0.647058823529412 18.4 18 4 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0231467346848697 0.0467866526371726 1.0574623388725 0.647058823529412 18.4 18 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.02739657057216e-05 8.6636195793519e-05 1.05436127629516 0.645161290322581 18.4 18 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.0519455701164e-08 2.63283951884733e-07 1.05284056291589 0.644230769230769 18.4 18 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.36025246910353e-07 2.87835443906956e-06 1.05193745726919 0.64367816091954 18.4 18 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 7.20141065132895e-06 3.25320868471146e-05 1.05059570030839 0.642857142857143 18.4 18 4 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00425187963811069 0.0103780870069151 1.05059570030839 0.642857142857143 18.4 18 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00425187963811069 0.0103780870069151 1.05059570030839 0.642857142857143 18.4 18 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0416972796024544 0.0775386009137543 1.05059570030839 0.642857142857143 18.4 18 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0416972796024544 0.0775386009137543 1.05059570030839 0.642857142857143 18.4 18 4 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0416972796024544 0.0775386009137543 1.05059570030839 0.642857142857143 18.4 18 4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0416972796024544 0.0775386009137543 1.05059570030839 0.642857142857143 18.4 18 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0416972796024544 0.0775386009137543 1.05059570030839 0.642857142857143 18.4 18 4 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0416972796024544 0.0775386009137543 1.05059570030839 0.642857142857143 18.4 18 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0416972796024544 0.0775386009137543 1.05059570030839 0.642857142857143 18.4 18 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00740932993573426 0.0171645224781035 1.0459263860848 0.64 18.4 18 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00740932993573426 0.0171645224781035 1.0459263860848 0.64 18.4 18 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00740932993573426 0.0171645224781035 1.0459263860848 0.64 18.4 18 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00740932993573426 0.0171645224781035 1.0459263860848 0.64 18.4 18 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.50245175519861e-08 1.7038224151424e-07 1.04533746357011 0.63963963963964 18.4 18 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 9.18071967871257e-07 4.68249609419641e-06 1.04516626516468 0.63953488372093 18.4 18 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.7771131016014e-24 1.40490663532155e-22 1.04435330161375 0.63903743315508 18.4 18 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 5.88620368064538e-17 2.26380211825902e-15 1.04411054166451 0.638888888888889 18.4 18 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 5.88620368064538e-17 2.26380211825902e-15 1.04411054166451 0.638888888888889 18.4 18 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 5.88620368064538e-17 2.26380211825902e-15 1.04411054166451 0.638888888888889 18.4 18 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.54547766687996e-06 7.71654287708838e-06 1.04356360057406 0.63855421686747 18.4 18 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 5.9104568116249e-05 0.000222875095958567 1.04254515854357 0.637931034482759 18.4 18 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 5.9104568116249e-05 0.000222875095958567 1.04254515854357 0.637931034482759 18.4 18 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 5.9104568116249e-05 0.000222875095958567 1.04254515854357 0.637931034482759 18.4 18 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 5.87143012394632e-15 1.19357786662509e-13 1.04064985162585 0.63677130044843 18.4 18 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.25490129167605e-08 2.75214751729773e-07 1.0399836225275 0.636363636363636 18.4 18 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0129812425513396 0.0286003101933181 1.0399836225275 0.636363636363636 18.4 18 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0764035409553786 0.131784531853944 1.0399836225275 0.636363636363636 18.4 18 4 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0764035409553786 0.131784531853944 1.0399836225275 0.636363636363636 18.4 18 4 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0764035409553786 0.131784531853944 1.0399836225275 0.636363636363636 18.4 18 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00246308391885769 0.00641935607423899 1.0399836225275 0.636363636363636 18.4 18 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.41300085681027e-48 6.86740043848202e-46 1.03789110014816 0.635083226632522 18.4 18 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000288832411350574 0.00096254923033224 1.03391957808127 0.63265306122449 18.4 18 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0228973453973268 0.0466136230334706 1.03216419679421 0.631578947368421 18.4 18 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.56044276252443e-08 1.08848531915307e-07 1.03145916660514 0.631147540983607 18.4 18 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 4.43778373183802e-06 2.09799543202841e-05 1.02897850482879 0.62962962962963 18.4 18 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 2.1028224121228e-05 8.89738031204001e-05 1.02724912919042 0.628571428571429 18.4 18 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.68920243019303e-31 2.67081673129409e-29 1.02523800134131 0.627340823970037 18.4 18 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 2.02942686667266e-07 1.14145234437755e-06 1.02332166862852 0.626168224299065 18.4 18 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 4.60821393724757e-12 5.6530072695718e-11 1.02141248641093 0.625 18.4 18 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000489089529069449 0.00155698970887209 1.02141248641093 0.625 18.4 18 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00421652473126543 0.0103477101091478 1.02141248641093 0.625 18.4 18 4 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0407407646534669 0.0771096539151902 1.02141248641093 0.625 18.4 18 4 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0407407646534669 0.0771096539151902 1.02141248641093 0.625 18.4 18 4 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.143702247301617 0.227331790275641 1.02141248641093 0.625 18.4 18 4 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.143702247301617 0.227331790275641 1.02141248641093 0.625 18.4 18 4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.143702247301617 0.227331790275641 1.02141248641093 0.625 18.4 18 4 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.143702247301617 0.227331790275641 1.02141248641093 0.625 18.4 18 4 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.143702247301617 0.227331790275641 1.02141248641093 0.625 18.4 18 4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.143702247301617 0.227331790275641 1.02141248641093 0.625 18.4 18 4 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.143702247301617 0.227331790275641 1.02141248641093 0.625 18.4 18 4 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.143702247301617 0.227331790275641 1.02141248641093 0.625 18.4 18 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.4036802158968e-09 2.53583086241945e-08 1.0171268396148 0.622377622377622 18.4 18 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 5.92036446045947e-05 0.000222875095958567 1.01522210770541 0.621212121212121 18.4 18 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.34983257175515e-08 2.80081979620252e-07 1.01482272843409 0.620967741935484 18.4 18 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0223898865830331 0.0456458576040919 1.01168474844511 0.619047619047619 18.4 18 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0125338651932501 0.0277382428771304 1.00569844815846 0.615384615384615 18.4 18 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0125338651932501 0.0277382428771304 1.00569844815846 0.615384615384615 18.4 18 4 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0125338651932501 0.0277382428771304 1.00569844815846 0.615384615384615 18.4 18 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0125338651932501 0.0277382428771304 1.00569844815846 0.615384615384615 18.4 18 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0125338651932501 0.0277382428771304 1.00569844815846 0.615384615384615 18.4 18 4 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0733343071844572 0.126952213045599 1.00569844815846 0.615384615384615 18.4 18 4 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0733343071844572 0.126952213045599 1.00569844815846 0.615384615384615 18.4 18 4 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0733343071844572 0.126952213045599 1.00569844815846 0.615384615384615 18.4 18 4 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0733343071844572 0.126952213045599 1.00569844815846 0.615384615384615 18.4 18 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 8.03299831274544e-18 3.94170917208164e-16 1.00261348359355 0.613496932515337 18.4 18 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.93044033226238e-07 1.09442892143799e-06 0.99946478009136 0.611570247933884 18.4 18 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00406432905465511 0.0100408684805108 0.998714431157357 0.611111111111111 18.4 18 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0393625165917261 0.075489031145588 0.998714431157357 0.611111111111111 18.4 18 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.21767272353795e-06 2.00058276186484e-05 0.997758723567733 0.610526315789474 18.4 18 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.21767272353795e-06 2.00058276186484e-05 0.997758723567733 0.610526315789474 18.4 18 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00234109982456738 0.00617561908918358 0.996499986742374 0.609756097560976 18.4 18 4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0217087791774653 0.0445766129430492 0.99476694328717 0.608695652173913 18.4 18 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0217087791774653 0.0445766129430492 0.99476694328717 0.608695652173913 18.4 18 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.30765793499613e-05 0.00012966383585398 0.992968088055186 0.607594936708861 18.4 18 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 3.24056178258811e-05 0.00012738451427135 0.988626406600212 0.604938271604938 18.4 18 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0013227292700091 0.00371984931071729 0.987365403530569 0.604166666666667 18.4 18 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.6642283314834e-74 2.36819691570088e-71 0.986464221866208 0.603615235635894 18.4 18 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.69179220348578e-14 6.4857040809386e-13 0.985275871368236 0.602888086642599 18.4 18 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 6.42006632158982e-06 2.93754159987856e-05 0.980555986954496 0.6 18.4 18 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000256568288039532 0.000857034445728295 0.980555986954496 0.6 18.4 18 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00128614614950992 0.00363520689908006 0.980555986954496 0.6 18.4 18 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0377376705610504 0.0735626098744859 0.980555986954496 0.6 18.4 18 4 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0377376705610504 0.0735626098744859 0.980555986954496 0.6 18.4 18 4 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0377376705610504 0.0735626098744859 0.980555986954496 0.6 18.4 18 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0377376705610504 0.0735626098744859 0.980555986954496 0.6 18.4 18 4 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.134156193180972 0.219178258204963 0.980555986954496 0.6 18.4 18 4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.134156193180972 0.219178258204963 0.980555986954496 0.6 18.4 18 4 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.134156193180972 0.219178258204963 0.980555986954496 0.6 18.4 18 4 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.134156193180972 0.219178258204963 0.980555986954496 0.6 18.4 18 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00669703188041584 0.0156999610639732 0.980555986954496 0.6 18.4 18 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00669703188041584 0.0156999610639732 0.980555986954496 0.6 18.4 18 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0117707065662981 0.0262534724825113 0.980555986954496 0.6 18.4 18 4 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0697143818816508 0.124471223861467 0.980555986954496 0.6 18.4 18 4 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0697143818816508 0.124471223861467 0.980555986954496 0.6 18.4 18 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 9.52318852331834e-27 8.46968579292625e-25 0.978838726031634 0.598949211908932 18.4 18 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 5.12824548934074e-08 3.2006549698824e-07 0.968064827885012 0.592356687898089 18.4 18 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 9.38246621414595e-06 4.18534464662373e-05 0.964991606209187 0.59047619047619 18.4 18 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00621395706932177 0.0146641142780181 0.963794346151855 0.58974358974359 18.4 18 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00621395706932177 0.0146641142780181 0.963794346151855 0.58974358974359 18.4 18 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0108603387428613 0.0244529462517272 0.961329398974996 0.588235294117647 18.4 18 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0658750931800346 0.118209656488259 0.961329398974996 0.588235294117647 18.4 18 4 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0658750931800346 0.118209656488259 0.961329398974996 0.588235294117647 18.4 18 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0658750931800346 0.118209656488259 0.961329398974996 0.588235294117647 18.4 18 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00595929048731812 0.0142044729706092 0.956639987272679 0.585365853658537 18.4 18 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00191923025405448 0.00514324793129853 0.955887911810987 0.584905660377358 18.4 18 4 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0103828158364808 0.0234148128927293 0.953318320650204 0.583333333333333 18.4 18 4 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0341651295036725 0.0669655362034794 0.953318320650204 0.583333333333333 18.4 18 4 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0341651295036725 0.0669655362034794 0.953318320650204 0.583333333333333 18.4 18 4 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.12462878516218 0.204788407951249 0.953318320650204 0.583333333333333 18.4 18 4 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.12462878516218 0.204788407951249 0.953318320650204 0.583333333333333 18.4 18 4 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.12462878516218 0.204788407951249 0.953318320650204 0.583333333333333 18.4 18 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00184113365319682 0.00494327016697939 0.950842169167996 0.581818181818182 18.4 18 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0182309849450537 0.0387004818649389 0.948925148665641 0.580645161290323 18.4 18 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0182309849450537 0.0387004818649389 0.948925148665641 0.580645161290323 18.4 18 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0182309849450537 0.0387004818649389 0.948925148665641 0.580645161290323 18.4 18 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00315966363467289 0.00800035827782834 0.947870787389346 0.58 18.4 18 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000328944204390114 0.00108353611770169 0.946150513728023 0.578947368421053 18.4 18 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00990199357208457 0.0225809885465967 0.946150513728023 0.578947368421053 18.4 18 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0620021269840252 0.111682312276288 0.946150513728023 0.578947368421053 18.4 18 4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0620021269840252 0.111682312276288 0.946150513728023 0.578947368421053 18.4 18 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0620021269840252 0.111682312276288 0.946150513728023 0.578947368421053 18.4 18 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.0323425682075666 0.0637444245974617 0.942842295148554 0.576923076923077 18.4 18 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0323425682075666 0.0637444245974617 0.942842295148554 0.576923076923077 18.4 18 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 5.63530562729262e-09 4.07057863331847e-08 0.941645035091223 0.576190476190476 18.4 18 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0173147089742064 0.0373315619246905 0.940937563239163 0.575757575757576 18.4 18 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0173147089742064 0.0373315619246905 0.940937563239163 0.575757575757576 18.4 18 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 7.29328805383568e-19 3.84383292615118e-17 0.940031654160306 0.57520325203252 18.4 18 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.009423988393092 0.0215254181113482 0.939699487498059 0.575 18.4 18 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.77115983248252e-07 3.58191837978536e-06 0.93838153590269 0.574193548387097 18.4 18 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00160994096528037 0.00442267566330881 0.937690151459218 0.573770491803279 18.4 18 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 3.03482219188047e-05 0.00011995977719572 0.935985260274746 0.572727272727273 18.4 18 4 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.115517010627128 0.190918357865741 0.933862844718568 0.571428571428571 18.4 18 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.115517010627128 0.190918357865741 0.933862844718568 0.571428571428571 18.4 18 4 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.115517010627128 0.190918357865741 0.933862844718568 0.571428571428571 18.4 18 4 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.115517010627128 0.190918357865741 0.933862844718568 0.571428571428571 18.4 18 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.115517010627128 0.190918357865741 0.933862844718568 0.571428571428571 18.4 18 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.28243842558059e-34 4.05988734950148e-32 0.927552960632631 0.567567567567568 18.4 18 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.028796184784908 0.0575519254900619 0.926080654345913 0.566666666666667 18.4 18 4 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.028796184784908 0.0575519254900619 0.926080654345913 0.566666666666667 18.4 18 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.32656823974707e-22 2.25414600245718e-20 0.925148727971583 0.566096423017107 18.4 18 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000217024741476967 0.000734006882908128 0.921444455826034 0.563829787234043 18.4 18 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00422381289056691 0.0103477101091478 0.921128351381496 0.563636363636364 18.4 18 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.98024053803668e-07 1.11820725620087e-06 0.91927123776984 0.5625 18.4 18 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.027108186915438 0.0544843926280625 0.91927123776984 0.5625 18.4 18 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.106966175460744 0.178444159062883 0.91927123776984 0.5625 18.4 18 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.106966175460744 0.178444159062883 0.91927123776984 0.5625 18.4 18 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0510296048351027 0.0938179944190582 0.915185587824196 0.56 18.4 18 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0477076364972205 0.0879377807455243 0.907922210143052 0.555555555555556 18.4 18 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.09901581391542 0.165959367728672 0.907922210143052 0.555555555555556 18.4 18 4 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.09901581391542 0.165959367728672 0.907922210143052 0.555555555555556 18.4 18 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.09901581391542 0.165959367728672 0.907922210143052 0.555555555555556 18.4 18 4 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.225446029935984 0.328026278730986 0.907922210143052 0.555555555555556 18.4 18 4 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.225446029935984 0.328026278730986 0.907922210143052 0.555555555555556 18.4 18 4 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.225446029935984 0.328026278730986 0.907922210143052 0.555555555555556 18.4 18 4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.225446029935984 0.328026278730986 0.907922210143052 0.555555555555556 18.4 18 4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.225446029935984 0.328026278730986 0.907922210143052 0.555555555555556 18.4 18 4 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.225446029935984 0.328026278730986 0.907922210143052 0.555555555555556 18.4 18 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0445730132131573 0.0822664044128701 0.901660677659307 0.551724137931034 18.4 18 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0109024162512753 0.0245089073073693 0.900510600264333 0.551020408163265 18.4 18 4 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0916586848343276 0.154172941512114 0.898842988041621 0.55 18.4 18 4 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.203459375851684 0.298477001893759 0.891414533594996 0.545454545454545 18.4 18 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0388603604449159 0.0746265761310598 0.891414533594996 0.545454545454545 18.4 18 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0173759078649026 0.0374068334217192 0.888184770792116 0.543478260869565 18.4 18 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0162790278790924 0.0352052533008336 0.885224154889476 0.541666666666667 18.4 18 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0162790278790924 0.0352052533008336 0.885224154889476 0.541666666666667 18.4 18 4 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0338503117465125 0.0665317591371371 0.883383772031078 0.540540540540541 18.4 18 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0142802385137182 0.0310715281422338 0.87998614213865 0.538461538461538 18.4 18 4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.184472342802855 0.275739646857629 0.87998614213865 0.538461538461538 18.4 18 4 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.184472342802855 0.275739646857629 0.87998614213865 0.538461538461538 18.4 18 4 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.184472342802855 0.275739646857629 0.87998614213865 0.538461538461538 18.4 18 4 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.184472342802855 0.275739646857629 0.87998614213865 0.538461538461538 18.4 18 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.184472342802855 0.275739646857629 0.87998614213865 0.538461538461538 18.4 18 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0675099308979586 0.120838530399742 0.875496416923657 0.535714285714286 18.4 18 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.24118288110332e-11 2.1404048589329e-10 0.872093889742788 0.533632286995516 18.4 18 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00213535104144929 0.00569027065914296 0.87160532173733 0.533333333333333 18.4 18 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0256687702467642 0.051664299945043 0.87160532173733 0.533333333333333 18.4 18 4 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.167862872050531 0.253845767192248 0.87160532173733 0.533333333333333 18.4 18 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.167862872050531 0.253845767192248 0.87160532173733 0.533333333333333 18.4 18 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 8.33651243326381e-06 3.75406873181469e-05 0.871052272675314 0.532994923857868 18.4 18 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.00422489077541454 0.0103477101091478 0.868847077048288 0.531645569620253 18.4 18 4 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.153193643026543 0.235924842020314 0.865196459077496 0.529411764705882 18.4 18 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 4.64116687265518e-05 0.000178015645816397 0.864637546636232 0.529069767441861 18.4 18 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00788585979900012 0.0180993201515761 0.863823131364675 0.528571428571429 18.4 18 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0500454525634382 0.0921276571769373 0.862526099635899 0.527777777777778 18.4 18 4 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.140142132728081 0.227331790275641 0.860136830661839 0.526315789473684 18.4 18 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.140142132728081 0.227331790275641 0.860136830661839 0.526315789473684 18.4 18 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.44293440855394e-06 7.2299143076488e-06 0.858787596417663 0.525490196078431 18.4 18 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.128461717367174 0.21084316472144 0.85604094099202 0.523809523809524 18.4 18 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.117958420099762 0.194501543223593 0.852657379960431 0.521739130434783 18.4 18 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 8.25359733541717e-11 7.43346139765736e-10 0.851796109879663 0.521212121212121 18.4 18 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0279810222209059 0.0561593718199563 0.848558065633699 0.519230769230769 18.4 18 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.099887236411852 0.167026483447785 0.847394062800182 0.518518518518518 18.4 18 4 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.099887236411852 0.167026483447785 0.847394062800182 0.518518518518518 18.4 18 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0183031794062571 0.0387004818649389 0.84266530128902 0.515625 18.4 18 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0784970465961139 0.132190884386118 0.84189150395083 0.515151515151515 18.4 18 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0784970465961139 0.132190884386118 0.84189150395083 0.515151515151515 18.4 18 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0784970465961139 0.132190884386118 0.84189150395083 0.515151515151515 18.4 18 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0725692077649142 0.126242032578818 0.840476560246711 0.514285714285714 18.4 18 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0671403234257481 0.120328312638337 0.839214583429524 0.513513513513513 18.4 18 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0575877452424965 0.104126253468961 0.837059988863594 0.51219512195122 18.4 18 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0016238039260727 0.00445216375106252 0.836432272336512 0.511811023622047 18.4 18 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000570053354520112 0.0017789164988643 0.83254753609344 0.509433962264151 18.4 18 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000570053354520112 0.0017789164988643 0.83254753609344 0.509433962264151 18.4 18 4 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0318170943686098 0.0635003159698903 0.831465602973111 0.508771929824561 18.4 18 4 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.025631618176146 0.0516625958422887 0.830100306416505 0.507936507936508 18.4 18 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.000925305697558051 0.00277202106868444 0.82220533067613 0.503105590062112 18.4 18 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000866540282221576 0.00260144899072005 0.822143056546714 0.503067484662577 18.4 18 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0011682094625666 0.00333807643620937 0.817129989128747 0.5 18.4 18 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0140868546540492 0.0307781164033501 0.817129989128747 0.5 18.4 18 4 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.11188294648895 0.186209862986872 0.817129989128747 0.5 18.4 18 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.172056573385762 0.25881237201685 0.817129989128747 0.5 18.4 18 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.172056573385762 0.25881237201685 0.817129989128747 0.5 18.4 18 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.188625580621834 0.281356605057515 0.817129989128747 0.5 18.4 18 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.207371472137666 0.303902785635323 0.817129989128747 0.5 18.4 18 4 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.228759568640316 0.331491717082658 0.817129989128747 0.5 18.4 18 4 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.228759568640316 0.331491717082658 0.817129989128747 0.5 18.4 18 4 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.228759568640316 0.331491717082658 0.817129989128747 0.5 18.4 18 4 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.228759568640316 0.331491717082658 0.817129989128747 0.5 18.4 18 4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.282289966541188 0.395357940119933 0.817129989128747 0.5 18.4 18 4 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.282289966541188 0.395357940119933 0.817129989128747 0.5 18.4 18 4 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.282289966541188 0.395357940119933 0.817129989128747 0.5 18.4 18 4 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.282289966541188 0.395357940119933 0.817129989128747 0.5 18.4 18 4 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.316735866690995 0.432035423071357 0.817129989128747 0.5 18.4 18 4 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.253427674978583 0.361350282058641 0.817129989128747 0.5 18.4 18 4 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.253427674978583 0.361350282058641 0.817129989128747 0.5 18.4 18 4 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.253427674978583 0.361350282058641 0.817129989128747 0.5 18.4 18 4 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.253427674978583 0.361350282058641 0.817129989128747 0.5 18.4 18 4 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.253427674978583 0.361350282058641 0.817129989128747 0.5 18.4 18 4 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.253427674978583 0.361350282058641 0.817129989128747 0.5 18.4 18 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000149955635500663 0.00052429206220502 0.81362299346725 0.497854077253219 18.4 18 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0154740297197458 0.0335663784926803 0.80834364515962 0.494623655913978 18.4 18 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00741825813354436 0.0171645224781035 0.803734415536472 0.491803278688525 18.4 18 4 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.112152943637749 0.186441166818361 0.796177938125445 0.487179487179487 18.4 18 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0051013330956521 0.012220870362143 0.790770957221368 0.483870967741935 18.4 18 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.155866267610306 0.237174394841218 0.790770957221368 0.483870967741935 18.4 18 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.169765261200211 0.25645007079395 0.788953092951893 0.482758620689655 18.4 18 4 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.202392865256401 0.298477001893759 0.784444789563597 0.48 18.4 18 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.000945421448804005 0.00282633344884054 0.781031877159204 0.477911646586345 18.4 18 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.151973295556329 0.234657524045546 0.774123147595655 0.473684210526316 18.4 18 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0153076610405074 0.0332561857414383 0.771094496783465 0.471830985915493 18.4 18 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.108206014021557 0.180301121724445 0.770877348234667 0.471698113207547 18.4 18 4 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.295929280297005 0.412445999865463 0.769063519179997 0.470588235294118 18.4 18 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.295929280297005 0.412445999865463 0.769063519179997 0.470588235294118 18.4 18 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0402020018999982 0.0769952203279912 0.768102189781022 0.47 18.4 18 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0222163099974552 0.0455530390870011 0.763449916850216 0.467153284671533 18.4 18 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00269830069114464 0.00696856966152237 0.762654656520164 0.466666666666667 18.4 18 4 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.21193898000973 0.310276922380499 0.762654656520164 0.466666666666667 18.4 18 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.32829687754063 0.438242454728251 0.762654656520164 0.466666666666667 18.4 18 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.32829687754063 0.438242454728251 0.762654656520164 0.466666666666667 18.4 18 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0247013491915771 0.049858184254772 0.758763561333836 0.464285714285714 18.4 18 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0280911571475988 0.0563010093253986 0.757046901692809 0.463235294117647 18.4 18 4 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.252339955262475 0.361350282058641 0.754273836118843 0.461538461538462 18.4 18 4 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.366133644031188 0.481968709950398 0.754273836118843 0.461538461538462 18.4 18 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0330927162078563 0.065132690406334 0.751521011899431 0.45985401459854 18.4 18 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.201671370953662 0.298477001893759 0.750876206226416 0.459459459459459 18.4 18 4 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.302706192076326 0.421478386814689 0.742845444662497 0.454545454545455 18.4 18 4 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.411132942390422 0.526732203572196 0.742845444662497 0.454545454545455 18.4 18 4 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.411132942390422 0.526732203572196 0.742845444662497 0.454545454545455 18.4 18 4 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.237483505736895 0.343433972219107 0.742845444662497 0.454545454545455 18.4 18 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.237483505736895 0.343433972219107 0.742845444662497 0.454545454545455 18.4 18 4 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.332720666048121 0.443316018526663 0.735416990215872 0.45 18.4 18 4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.332720666048121 0.443316018526663 0.735416990215872 0.45 18.4 18 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.117671814203502 0.194254050593483 0.724465763557446 0.443298969072165 18.4 18 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.188041287850901 0.280779383643056 0.723360973982825 0.442622950819672 18.4 18 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.405714784463095 0.522472523340257 0.714988740487653 0.4375 18.4 18 4 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.405714784463095 0.522472523340257 0.714988740487653 0.4375 18.4 18 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.171516947341476 0.258547262782754 0.711383755241497 0.435294117647059 18.4 18 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.171516947341476 0.258547262782754 0.711383755241497 0.435294117647059 18.4 18 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.265513565942718 0.378204008344833 0.710547816633693 0.434782608695652 18.4 18 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.173531490370664 0.260755344031103 0.705312201142708 0.431578947368421 18.4 18 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.285382771447338 0.398527658262572 0.700397133538926 0.428571428571429 18.4 18 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.307100302122522 0.427178621623019 0.700397133538926 0.428571428571429 18.4 18 4 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.399771164262387 0.515751919080124 0.700397133538926 0.428571428571429 18.4 18 4 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.450663120820643 0.571562942003364 0.700397133538926 0.428571428571429 18.4 18 4 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.450663120820643 0.571562942003364 0.700397133538926 0.428571428571429 18.4 18 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.323039838473594 0.432035423071357 0.683417809089497 0.418181818181818 18.4 18 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.323039838473594 0.432035423071357 0.683417809089497 0.418181818181818 18.4 18 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.348181850906048 0.463482482543785 0.680941657607289 0.416666666666667 18.4 18 4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.503163639425589 0.618309031867541 0.680941657607289 0.416666666666667 18.4 18 4 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.419764814479179 0.534280260289689 0.67624550824448 0.413793103448276 18.4 18 4 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.482564637379359 0.602317586890589 0.672930579282497 0.411764705882353 18.4 18 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.358056306628488 0.473523667036018 0.669778679613727 0.409836065573771 18.4 18 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.385568348063905 0.497879999360197 0.665809620771571 0.407407407407407 18.4 18 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.369549299226744 0.486015390757538 0.663177962191447 0.405797101449275 18.4 18 4 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.491703359252147 0.604748383937602 0.653703991302997 0.4 18.4 18 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.444222654207121 0.564400747264941 0.653703991302997 0.4 18.4 18 4 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.477209469549452 0.599354876583292 0.653703991302997 0.4 18.4 18 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.477209469549452 0.599354876583292 0.653703991302997 0.4 18.4 18 4 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.532240616340652 0.651280709531204 0.653703991302997 0.4 18.4 18 4 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.472850947750746 0.594930944871186 0.6461027821018 0.395348837209302 18.4 18 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.421404385470446 0.535887793140701 0.643799385374164 0.393939393939394 18.4 18 4 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.513690088449008 0.630156030916326 0.642030705744015 0.392857142857143 18.4 18 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.513690088449008 0.630156030916326 0.642030705744015 0.392857142857143 18.4 18 4 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.533481478885882 0.651280709531204 0.632616765777094 0.387096774193548 18.4 18 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.552860021854233 0.671835876258389 0.628561530099036 0.384615384615385 18.4 18 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.481150156704372 0.602317586890589 0.627202478142065 0.383783783783784 18.4 18 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.365473632540733 0.481545351023577 0.626599191663605 0.383414634146341 18.4 18 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.53608730427335 0.652010456393997 0.625886800183721 0.382978723404255 18.4 18 4 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.608156115467185 0.727619321403131 0.61284749184656 0.375 18.4 18 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.623176934222046 0.73548966368327 0.606257733869715 0.370967741935484 18.4 18 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.610887460532845 0.727619321403131 0.605281473428701 0.37037037037037 18.4 18 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.625440097081043 0.73548966368327 0.599228658694414 0.366666666666667 18.4 18 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.635546375298594 0.74496086659794 0.598461400488659 0.366197183098592 18.4 18 4 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.639545440018369 0.74782298364893 0.594276355729998 0.363636363636364 18.4 18 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.652799769660735 0.760440978204086 0.588333592172698 0.36 18.4 18 4 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.665554200839558 0.773761133819192 0.583664277949105 0.357142857142857 18.4 18 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.676017337088381 0.78528381279736 0.579898701962336 0.354838709677419 18.4 18 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.823192918540566 0.924548952709728 0.568004992443153 0.347560975609756 18.4 18 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.788815534292926 0.894409964381541 0.565705377089132 0.346153846153846 18.4 18 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.722334737226102 0.838403206421487 0.561776867526013 0.34375 18.4 18 4 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.730002883719173 0.842650127019078 0.560317706831141 0.342857142857143 18.4 18 4 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.736866528679131 0.845613766379357 0.544753326085831 0.333333333333333 18.4 18 4 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.732210993089011 0.842650127019078 0.544753326085831 0.333333333333333 18.4 18 4 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.732210993089011 0.842650127019078 0.544753326085831 0.333333333333333 18.4 18 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.851536419142595 0.938985603986795 0.537857714363226 0.329113924050633 18.4 18 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.818937964638816 0.920496622180912 0.533635911267753 0.326530612244898 18.4 18 4 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.798012646605615 0.899106885288828 0.527180638147578 0.32258064516129 18.4 18 4 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.830763466214511 0.932315782668177 0.497383471643585 0.304347826086957 18.4 18 4 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.86502165212374 0.952728955860744 0.476659160325102 0.291666666666667 18.4 18 4 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.907517606029412 0.982566797601296 0.473075256864011 0.289473684210526 18.4 18 4 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.873077100286036 0.957894150892081 0.453961105071526 0.277777777777778 18.4 18 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999693212264351 1 0.444337966438673 0.271889400921659 18.4 18 4 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.958513230574882 1 0.442612077444738 0.270833333333333 18.4 18 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.931575626046878 1 0.435802660868665 0.266666666666667 18.4 18 4 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.943678068634968 1 0.432598229538748 0.264705882352941 18.4 18 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.972215214351718 1 0.431691315011413 0.264150943396226 18.4 18 4 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.903254196550161 0.982566797601296 0.430068415330919 0.263157894736842 18.4 18 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999782073193 1 0.425413035577337 0.260309278350515 18.4 18 4 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.955756731144111 1 0.420238280123355 0.257142857142857 18.4 18 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.998463830235292 1 0.408564994564373 0.25 18.4 18 4 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.926965564753307 0.997785172953068 0.408564994564373 0.25 18.4 18 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.939645164811245 1 0.408564994564373 0.25 18.4 18 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999267077026 1 0.402728351784882 0.246428571428571 18.4 18 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.991229804315135 1 0.374517911684009 0.229166666666667 18.4 18 4 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999533738655933 1 0.363168884057221 0.222222222222222 18.4 18 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999997677130391 1 0.362137154272967 0.221590909090909 18.4 18 4 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.980925708223461 1 0.350198566769463 0.214285714285714 18.4 18 4 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.984108135630582 1 0.326851995651499 0.2 18.4 18 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.312855814477505 0.191435768261965 18.4 18 4 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.9979019455553 1 0.263590319073789 0.161290322580645 18.4 18 4 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.9979019455553 1 0.263590319073789 0.161290322580645 18.4 18 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.263018332847951 0.160940325497288 18.4 18 4 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999870786366983 1 0.243400422293669 0.148936170212766 18.4 18 4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 9.62931418542213e-05 0.000459815908921332 2.74685222001325 1 18.3 18 3 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00135305500696195 0.00469609091440695 2.74685222001325 1 18.3 18 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.000360971572216123 0.00148029552525517 2.74685222001325 1 18.3 18 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.000360971572216123 0.00148029552525517 2.74685222001325 1 18.3 18 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.000360971572216123 0.00148029552525517 2.74685222001325 1 18.3 18 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 4.41761292808872e-06 2.85739236212284e-05 2.51794786834548 0.916666666666667 18.3 18 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 4.95171517398124e-09 5.14327787779219e-08 2.47216699801193 0.9 18.3 18 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 5.20634448692329e-05 0.000268428558148255 2.47216699801193 0.9 18.3 18 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 5.20634448692329e-05 0.000268428558148255 2.47216699801193 0.9 18.3 18 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 5.63751929559953e-08 4.98272668176281e-07 2.44164641778956 0.888888888888889 18.3 18 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.000590548915224548 0.00227121920639063 2.4034956925116 0.875 18.3 18 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000590548915224548 0.00227121920639063 2.4034956925116 0.875 18.3 18 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000590548915224548 0.00227121920639063 2.4034956925116 0.875 18.3 18 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.43866216637117e-09 2.71110645527045e-08 2.38856714783761 0.869565217391304 18.3 18 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 6.72349713285977e-06 4.21477375333015e-05 2.35444476001136 0.857142857142857 18.3 18 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00194904215438753 0.00621858068541134 2.35444476001136 0.857142857142857 18.3 18 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 2.17114431138238e-05 0.000122116140517673 2.32425957078045 0.846153846153846 18.3 18 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 2.17114431138238e-05 0.000122116140517673 2.32425957078045 0.846153846153846 18.3 18 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 8.4899568395729e-07 6.22742710449084e-06 2.28904351667771 0.833333333333333 18.3 18 3 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00631347218069108 0.0166064157359028 2.28904351667771 0.833333333333333 18.3 18 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00631347218069108 0.0166064157359028 2.28904351667771 0.833333333333333 18.3 18 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.00631347218069108 0.0166064157359028 2.28904351667771 0.833333333333333 18.3 18 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 3.42898497436671e-08 3.16847118085963e-07 2.26913879044573 0.826086956521739 18.3 18 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.33048235163115e-11 3.64425976524299e-10 2.21274206612179 0.805555555555556 18.3 18 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 1.0038232039549e-06 7.32533548321963e-06 2.1974817760106 0.8 18.3 18 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 2.53758507854894e-05 0.000141054045577154 2.1974817760106 0.8 18.3 18 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 2.53758507854894e-05 0.000141054045577154 2.1974817760106 0.8 18.3 18 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.000673551361748389 0.00248951581238431 2.1974817760106 0.8 18.3 18 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000673551361748389 0.00248951581238431 2.1974817760106 0.8 18.3 18 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.000673551361748389 0.00248951581238431 2.1974817760106 0.8 18.3 18 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 1.23067295693013e-07 1.04240929625689e-06 2.17459134084383 0.791666666666667 18.3 18 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.45965918538061e-13 4.72067050181047e-12 2.16241557745724 0.787234042553192 18.3 18 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 3.6736246983317e-07 2.85659450586121e-06 2.14971043305385 0.782608695652174 18.3 18 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 9.02519607792678e-06 5.46504426335737e-05 2.13644061556586 0.777777777777778 18.3 18 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 9.02519607792678e-06 5.46504426335737e-05 2.13644061556586 0.777777777777778 18.3 18 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00204020651965274 0.00632508470036133 2.13644061556586 0.777777777777778 18.3 18 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000227771394380416 0.000973329412022019 2.11296324616404 0.769230769230769 18.3 18 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.000227771394380416 0.000973329412022019 2.11296324616404 0.769230769230769 18.3 18 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 2.65154662419343e-05 0.000146815208024407 2.10053405059837 0.764705882352941 18.3 18 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 7.23453231637484e-10 8.66364902662114e-09 2.07869897730733 0.756756756756757 18.3 18 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.13563361956101e-11 1.97073980565283e-10 2.07539945512113 0.755555555555556 18.3 18 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.43020130725791e-12 3.76884529671853e-11 2.07415371715287 0.755102040816326 18.3 18 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 9.104250227897e-06 5.4895542687701e-05 2.06013916500994 0.75 18.3 18 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 7.66706484365489e-05 0.000372362910324946 2.06013916500994 0.75 18.3 18 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 7.66706484365489e-05 0.000372362910324946 2.06013916500994 0.75 18.3 18 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000663549155842028 0.0024718074574953 2.06013916500994 0.75 18.3 18 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000663549155842028 0.0024718074574953 2.06013916500994 0.75 18.3 18 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000663549155842028 0.0024718074574953 2.06013916500994 0.75 18.3 18 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.000663549155842028 0.0024718074574953 2.06013916500994 0.75 18.3 18 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.00602452187187648 0.0160241021003369 2.06013916500994 0.75 18.3 18 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.00602452187187648 0.0160241021003369 2.06013916500994 0.75 18.3 18 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00602452187187648 0.0160241021003369 2.06013916500994 0.75 18.3 18 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00602452187187648 0.0160241021003369 2.06013916500994 0.75 18.3 18 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00602452187187648 0.0160241021003369 2.06013916500994 0.75 18.3 18 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.9550180426368e-15 2.21315298666956e-13 2.04923895778767 0.746031746031746 18.3 18 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 3.23124740536455e-11 4.88676938104891e-10 2.03028207566197 0.739130434782609 18.3 18 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 2.04499771484045e-09 2.30954900652219e-08 2.02399637264135 0.736842105263158 18.3 18 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000217718579254999 0.000950348276932097 2.01435829467639 0.733333333333333 18.3 18 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000217718579254999 0.000950348276932097 2.01435829467639 0.733333333333333 18.3 18 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000217718579254999 0.000950348276932097 2.01435829467639 0.733333333333333 18.3 18 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 7.14376663049288e-10 8.66364902662114e-09 2.00989186830238 0.731707317073171 18.3 18 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 7.14376663049288e-10 8.66364902662114e-09 2.00989186830238 0.731707317073171 18.3 18 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.06583682943112e-06 7.62509839951397e-06 2.00731508385584 0.730769230769231 18.3 18 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 7.62673375941572e-19 8.34834010742198e-17 2.00358632518614 0.729411764705882 18.3 18 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00188879474339615 0.00603989869629826 1.99771070546418 0.727272727272727 18.3 18 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00188879474339615 0.00603989869629826 1.99771070546418 0.727272727272727 18.3 18 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00188879474339615 0.00603989869629826 1.99771070546418 0.727272727272727 18.3 18 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00188879474339615 0.00603989869629826 1.99771070546418 0.727272727272727 18.3 18 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00188879474339615 0.00603989869629826 1.99771070546418 0.727272727272727 18.3 18 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00188879474339615 0.00603989869629826 1.99771070546418 0.727272727272727 18.3 18 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 7.19901686683536e-05 0.000354470622889506 1.98383771445402 0.722222222222222 18.3 18 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 7.19901686683536e-05 0.000354470622889506 1.98383771445402 0.722222222222222 18.3 18 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.94322808120056e-06 1.95351591051583e-05 1.97773359840954 0.72 18.3 18 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.94322808120056e-06 1.95351591051583e-05 1.97773359840954 0.72 18.3 18 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.94322808120056e-06 1.95351591051583e-05 1.97773359840954 0.72 18.3 18 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 4.26754527788497e-08 3.81931882417e-07 1.96203730000947 0.714285714285714 18.3 18 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 4.26754527788497e-08 3.81931882417e-07 1.96203730000947 0.714285714285714 18.3 18 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 2.3956267537825e-05 0.000134211687820177 1.96203730000947 0.714285714285714 18.3 18 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000605531767721392 0.00229779121458011 1.96203730000947 0.714285714285714 18.3 18 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000605531767721392 0.00229779121458011 1.96203730000947 0.714285714285714 18.3 18 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.000605531767721392 0.00229779121458011 1.96203730000947 0.714285714285714 18.3 18 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0172245472464499 0.0402471768993403 1.96203730000947 0.714285714285714 18.3 18 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0172245472464499 0.0402471768993403 1.96203730000947 0.714285714285714 18.3 18 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0172245472464499 0.0402471768993403 1.96203730000947 0.714285714285714 18.3 18 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0172245472464499 0.0402471768993403 1.96203730000947 0.714285714285714 18.3 18 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0172245472464499 0.0402471768993403 1.96203730000947 0.714285714285714 18.3 18 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000197043085703624 0.000876225971738301 1.93895450824465 0.705882352941177 18.3 18 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000197043085703624 0.000876225971738301 1.93895450824465 0.705882352941177 18.3 18 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.69228525974304e-06 1.83307269120304e-05 1.93297008075007 0.703703703703704 18.3 18 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.33799945099073e-08 1.32220362413875e-07 1.92279655400928 0.7 18.3 18 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 6.48058868292025e-05 0.000322404363283045 1.92279655400928 0.7 18.3 18 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 6.48058868292025e-05 0.000322404363283045 1.92279655400928 0.7 18.3 18 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 6.48058868292025e-05 0.000322404363283045 1.92279655400928 0.7 18.3 18 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 6.48058868292025e-05 0.000322404363283045 1.92279655400928 0.7 18.3 18 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 6.48058868292025e-05 0.000322404363283045 1.92279655400928 0.7 18.3 18 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 6.48058868292025e-05 0.000322404363283045 1.92279655400928 0.7 18.3 18 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0052290685547629 0.0142003140332588 1.92279655400928 0.7 18.3 18 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0052290685547629 0.0142003140332588 1.92279655400928 0.7 18.3 18 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0052290685547629 0.0142003140332588 1.92279655400928 0.7 18.3 18 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.28276590830125e-13 4.24506020351787e-12 1.91085371827009 0.695652173913043 18.3 18 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 7.1673583976818e-06 4.47331184206193e-05 1.90166692154764 0.692307692307692 18.3 18 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00164404911913065 0.00540296050005293 1.90166692154764 0.692307692307692 18.3 18 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00164404911913065 0.00540296050005293 1.90166692154764 0.692307692307692 18.3 18 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00164404911913065 0.00540296050005293 1.90166692154764 0.692307692307692 18.3 18 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000528024027055589 0.00208138002908616 1.88846090125911 0.6875 18.3 18 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000528024027055589 0.00208138002908616 1.88846090125911 0.6875 18.3 18 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000528024027055589 0.00208138002908616 1.88846090125911 0.6875 18.3 18 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000528024027055589 0.00208138002908616 1.88846090125911 0.6875 18.3 18 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00017203692816516 0.000779708386409924 1.87942520316696 0.684210526315789 18.3 18 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.9295218462664e-11 3.05078843026343e-10 1.87701568367572 0.683333333333333 18.3 18 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.9295218462664e-11 3.05078843026343e-10 1.87701568367572 0.683333333333333 18.3 18 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.9295218462664e-11 3.05078843026343e-10 1.87701568367572 0.683333333333333 18.3 18 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.9295218462664e-11 3.05078843026343e-10 1.87701568367572 0.683333333333333 18.3 18 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.9295218462664e-11 3.05078843026343e-10 1.87701568367572 0.683333333333333 18.3 18 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.9295218462664e-11 3.05078843026343e-10 1.87701568367572 0.683333333333333 18.3 18 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.9295218462664e-11 3.05078843026343e-10 1.87701568367572 0.683333333333333 18.3 18 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 1.87885078862684e-05 0.0001073736816151 1.86785950960901 0.68 18.3 18 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 8.48291414707976e-15 4.8284747325178e-13 1.84200678283242 0.670588235294118 18.3 18 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 8.48291414707976e-15 4.8284747325178e-13 1.84200678283242 0.670588235294118 18.3 18 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 8.48291414707976e-15 4.8284747325178e-13 1.84200678283242 0.670588235294118 18.3 18 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 5.39306682188559e-06 3.39572304758548e-05 1.83123481334217 0.666666666666667 18.3 18 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 4.84281223617326e-05 0.000254292317788729 1.83123481334217 0.666666666666667 18.3 18 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 4.84281223617326e-05 0.000254292317788729 1.83123481334217 0.666666666666667 18.3 18 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000146505125411957 0.000674682179486132 1.83123481334217 0.666666666666667 18.3 18 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000146505125411957 0.000674682179486132 1.83123481334217 0.666666666666667 18.3 18 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000447148919774164 0.00179237440236236 1.83123481334217 0.666666666666667 18.3 18 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00138115814465418 0.00477750278134459 1.83123481334217 0.666666666666667 18.3 18 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0043392859185044 0.0123920182071901 1.83123481334217 0.666666666666667 18.3 18 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0043392859185044 0.0123920182071901 1.83123481334217 0.666666666666667 18.3 18 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0043392859185044 0.0123920182071901 1.83123481334217 0.666666666666667 18.3 18 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0043392859185044 0.0123920182071901 1.83123481334217 0.666666666666667 18.3 18 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0043392859185044 0.0123920182071901 1.83123481334217 0.666666666666667 18.3 18 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0043392859185044 0.0123920182071901 1.83123481334217 0.666666666666667 18.3 18 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0139931525763239 0.0338068864450067 1.83123481334217 0.666666666666667 18.3 18 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0139931525763239 0.0338068864450067 1.83123481334217 0.666666666666667 18.3 18 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0139931525763239 0.0338068864450067 1.83123481334217 0.666666666666667 18.3 18 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0139931525763239 0.0338068864450067 1.83123481334217 0.666666666666667 18.3 18 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0139931525763239 0.0338068864450067 1.83123481334217 0.666666666666667 18.3 18 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0139931525763239 0.0338068864450067 1.83123481334217 0.666666666666667 18.3 18 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.54202597840953e-06 1.08093742230382e-05 1.80507431600871 0.657142857142857 18.3 18 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 4.5744678830893e-06 2.94546054191678e-05 1.8026217693837 0.65625 18.3 18 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 4.74554213611042e-15 3.37645322984257e-13 1.80169876796568 0.655913978494624 18.3 18 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.07395680313763e-05 0.000217125113515537 1.79601875923944 0.653846153846154 18.3 18 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.23502714834734e-12 1.44672143606151e-10 1.79308408806421 0.652777777777778 18.3 18 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000122535356253257 0.000575471326562326 1.79142536087821 0.652173913043478 18.3 18 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 8.30205408348543e-13 2.27188903092303e-11 1.78545394300861 0.65 18.3 18 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000371180290646226 0.00151343711630252 1.78545394300861 0.65 18.3 18 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.46798121721452e-08 1.43077895349059e-07 1.77737496589093 0.647058823529412 18.3 18 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.46798121721452e-08 1.43077895349059e-07 1.77737496589093 0.647058823529412 18.3 18 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00113482241953419 0.00395797133087538 1.77737496589093 0.647058823529412 18.3 18 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00113482241953419 0.00395797133087538 1.77737496589093 0.647058823529412 18.3 18 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.25722575965983e-07 1.05237191529173e-06 1.77019365289743 0.644444444444444 18.3 18 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.22399894885658e-09 4.4196694883992e-08 1.76583357000852 0.642857142857143 18.3 18 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 3.38410756009099e-05 0.000183409574187673 1.76583357000852 0.642857142857143 18.3 18 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00351338035166732 0.0102659963869047 1.76583357000852 0.642857142857143 18.3 18 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00351338035166732 0.0102659963869047 1.76583357000852 0.642857142857143 18.3 18 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00351338035166732 0.0102659963869047 1.76583357000852 0.642857142857143 18.3 18 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.44125419002762e-10 1.88156395633881e-09 1.76290515612791 0.641791044776119 18.3 18 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.11788246828402e-20 4.43674675236816e-18 1.75877588187899 0.640287769784173 18.3 18 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 6.01188116063786e-15 3.88859404163076e-13 1.75798542080848 0.64 18.3 18 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 3.18870237806612e-06 2.08143279082022e-05 1.75493336278625 0.638888888888889 18.3 18 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 3.18870237806612e-06 2.08143279082022e-05 1.75493336278625 0.638888888888889 18.3 18 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.06522256667072e-07 2.40984072506765e-06 1.74799686728116 0.636363636363636 18.3 18 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000303781220250702 0.00127893691247559 1.74799686728116 0.636363636363636 18.3 18 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0110745477246547 0.027599091790164 1.74799686728116 0.636363636363636 18.3 18 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0110745477246547 0.027599091790164 1.74799686728116 0.636363636363636 18.3 18 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0110745477246547 0.027599091790164 1.74799686728116 0.636363636363636 18.3 18 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0110745477246547 0.027599091790164 1.74799686728116 0.636363636363636 18.3 18 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0110745477246547 0.027599091790164 1.74799686728116 0.636363636363636 18.3 18 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0110745477246547 0.027599091790164 1.74799686728116 0.636363636363636 18.3 18 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0110745477246547 0.027599091790164 1.74799686728116 0.636363636363636 18.3 18 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.78320399071983e-05 0.000152915030069279 1.73967307267506 0.633333333333333 18.3 18 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.4923110755868e-14 1.71364091743449e-12 1.73780446572267 0.63265306122449 18.3 18 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000918769476818173 0.00327671419927885 1.73485403369258 0.631578947368421 18.3 18 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000918769476818173 0.00327671419927885 1.73485403369258 0.631578947368421 18.3 18 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000918769476818173 0.00327671419927885 1.73485403369258 0.631578947368421 18.3 18 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 8.25970757396653e-05 0.000398425894161165 1.72949954593427 0.62962962962963 18.3 18 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 8.25970757396653e-05 0.000398425894161165 1.72949954593427 0.62962962962963 18.3 18 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.89833605599522e-11 9.6238551055698e-10 1.72136072454164 0.626666666666667 18.3 18 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.89833605599522e-11 9.6238551055698e-10 1.72136072454164 0.626666666666667 18.3 18 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.89833605599522e-11 9.6238551055698e-10 1.72136072454164 0.626666666666667 18.3 18 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.89833605599522e-11 9.6238551055698e-10 1.72136072454164 0.626666666666667 18.3 18 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.89833605599522e-11 9.6238551055698e-10 1.72136072454164 0.626666666666667 18.3 18 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00280304834065184 0.00832721876565255 1.71678263750828 0.625 18.3 18 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00280304834065184 0.00832721876565255 1.71678263750828 0.625 18.3 18 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00280304834065184 0.00832721876565255 1.71678263750828 0.625 18.3 18 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00280304834065184 0.00832721876565255 1.71678263750828 0.625 18.3 18 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0358912562040724 0.0748874744551246 1.71678263750828 0.625 18.3 18 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0358912562040724 0.0748874744551246 1.71678263750828 0.625 18.3 18 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0358912562040724 0.0748874744551246 1.71678263750828 0.625 18.3 18 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0358912562040724 0.0748874744551246 1.71678263750828 0.625 18.3 18 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.08065220255365e-07 1.67275033007562e-06 1.71678263750828 0.625 18.3 18 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.67170282280055e-11 6.85343620293318e-10 1.70374378203354 0.620253164556962 18.3 18 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.67170282280055e-11 6.85343620293318e-10 1.70374378203354 0.620253164556962 18.3 18 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.000736277434151913 0.00270031646597467 1.70043232667487 0.619047619047619 18.3 18 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000736277434151913 0.00270031646597467 1.70043232667487 0.619047619047619 18.3 18 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000736277434151913 0.00270031646597467 1.70043232667487 0.619047619047619 18.3 18 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.92268209451851e-07 3.7260513938829e-06 1.69486626341243 0.617021276595745 18.3 18 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 5.10410151635614e-06 3.22806064789991e-05 1.69037059693123 0.615384615384615 18.3 18 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.10801934687021e-08 1.11036023281431e-07 1.68355458645974 0.612903225806452 18.3 18 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.3045439798894e-20 5.56851462125692e-18 1.68244698475812 0.6125 18.3 18 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 3.99346013550914e-07 3.07172636369162e-06 1.68174625715097 0.612244897959184 18.3 18 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 3.14465279101294e-09 3.33943352359061e-08 1.6809095674708 0.611940298507463 18.3 18 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 3.14465279101294e-09 3.33943352359061e-08 1.6809095674708 0.611940298507463 18.3 18 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00221545220487138 0.00680904640935631 1.67863191223032 0.611111111111111 18.3 18 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.55216083385168e-09 2.79363451274688e-08 1.67199700348633 0.608695652173913 18.3 18 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.55216083385168e-09 2.79363451274688e-08 1.67199700348633 0.608695652173913 18.3 18 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 4.31695246562015e-05 0.00022921728949916 1.66475892122015 0.606060606060606 18.3 18 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.94080934743129e-13 1.1682857711239e-11 1.66395855635418 0.605769230769231 18.3 18 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.67401981447517e-10 2.14606323963799e-09 1.66167603432901 0.604938271604938 18.3 18 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.67401981447517e-10 2.14606323963799e-09 1.66167603432901 0.604938271604938 18.3 18 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 7.33129135352843e-08 6.32268339155815e-07 1.65758323621489 0.603448275862069 18.3 18 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 7.33129135352843e-08 6.32268339155815e-07 1.65758323621489 0.603448275862069 18.3 18 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.09137447421305e-10 1.46818750386693e-09 1.64811133200795 0.6 18.3 18 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00174015325607609 0.00567944514540431 1.64811133200795 0.6 18.3 18 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00671171366218702 0.017524345947325 1.64811133200795 0.6 18.3 18 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00671171366218702 0.017524345947325 1.64811133200795 0.6 18.3 18 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00671171366218702 0.017524345947325 1.64811133200795 0.6 18.3 18 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0271392786086655 0.0583371502418897 1.64811133200795 0.6 18.3 18 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0271392786086655 0.0583371502418897 1.64811133200795 0.6 18.3 18 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0271392786086655 0.0583371502418897 1.64811133200795 0.6 18.3 18 3 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0271392786086655 0.0583371502418897 1.64811133200795 0.6 18.3 18 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0271392786086655 0.0583371502418897 1.64811133200795 0.6 18.3 18 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 8.68520519086662e-10 1.02140884186803e-08 1.63420321950156 0.594936708860759 18.3 18 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000365197775049222 0.0014933230859053 1.62776427852637 0.592592592592593 18.3 18 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.07261603651743e-23 9.02291577495539e-21 1.62195083467449 0.59047619047619 18.3 18 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00518622822796276 0.0141923130161366 1.61579542353721 0.588235294117647 18.3 18 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00518622822796276 0.0141923130161366 1.61579542353721 0.588235294117647 18.3 18 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00518622822796276 0.0141923130161366 1.61579542353721 0.588235294117647 18.3 18 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.34364243636383e-06 9.51245366639665e-06 1.61579542353721 0.588235294117647 18.3 18 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000286889819589244 0.00121863944261341 1.61022371518018 0.586206896551724 18.3 18 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.00548436635841e-13 4.24506020351787e-12 1.6079134946419 0.585365853658537 18.3 18 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.71634637515185e-05 9.88810077668455e-05 1.6079134946419 0.585365853658537 18.3 18 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.71634637515185e-05 9.88810077668455e-05 1.6079134946419 0.585365853658537 18.3 18 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.06633491321383e-06 7.62509839951397e-06 1.60664941170587 0.584905660377358 18.3 18 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.30870453139228e-14 1.17331662434686e-12 1.60585206708467 0.584615384615385 18.3 18 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00106125977635736 0.00372882138705313 1.6023304616744 0.583333333333333 18.3 18 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00106125977635736 0.00372882138705313 1.6023304616744 0.583333333333333 18.3 18 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0205039142532651 0.045518049894534 1.6023304616744 0.583333333333333 18.3 18 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0205039142532651 0.045518049894534 1.6023304616744 0.583333333333333 18.3 18 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.37775551749783e-12 8.73917472981712e-11 1.59816856437135 0.581818181818182 18.3 18 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 1.35456480206849e-05 7.95921953860583e-05 1.59700710465887 0.581395348837209 18.3 18 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.000825764670543976 0.00298239372127939 1.58472243462303 0.576923076923077 18.3 18 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000825764670543976 0.00298239372127939 1.58472243462303 0.576923076923077 18.3 18 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 5.27927438346048e-07 3.91271221232514e-06 1.58293178780425 0.576271186440678 18.3 18 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 5.27927438346048e-07 3.91271221232514e-06 1.58293178780425 0.576271186440678 18.3 18 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.63057945685534e-19 8.77236754793225e-17 1.58242573544242 0.576086956521739 18.3 18 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 8.39533634921456e-06 5.12728052572203e-05 1.57797893490123 0.574468085106383 18.3 18 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.86353469435719e-06 1.28728634469431e-05 1.57689664482242 0.574074074074074 18.3 18 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.11247956893814e-08 1.99076716993309e-07 1.57486193947427 0.573333333333333 18.3 18 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000641531798085138 0.00241507870019881 1.56962984000757 0.571428571428571 18.3 18 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000641531798085138 0.00241507870019881 1.56962984000757 0.571428571428571 18.3 18 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.003078654351975 0.00908905631298843 1.56962984000757 0.571428571428571 18.3 18 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0155027107252825 0.0370762308606336 1.56962984000757 0.571428571428571 18.3 18 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0155027107252825 0.0370762308606336 1.56962984000757 0.571428571428571 18.3 18 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0155027107252825 0.0370762308606336 1.56962984000757 0.571428571428571 18.3 18 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0155027107252825 0.0370762308606336 1.56962984000757 0.571428571428571 18.3 18 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 9.0923027794148e-13 2.44119751983156e-11 1.55727054992877 0.566929133858268 18.3 18 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.83176251779825e-05 0.000105104760597859 1.55256864609445 0.565217391304348 18.3 18 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00236885163121158 0.0072027262205429 1.55256864609445 0.565217391304348 18.3 18 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00236885163121158 0.0072027262205429 1.55256864609445 0.565217391304348 18.3 18 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00236885163121158 0.0072027262205429 1.55256864609445 0.565217391304348 18.3 18 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.46775306946982e-13 1.27152252357111e-11 1.54897681579695 0.56390977443609 18.3 18 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.25571245341436e-07 1.05237191529173e-06 1.54752237747226 0.563380281690141 18.3 18 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 5.70753990752144e-25 1.35363821473384e-22 1.54510437375746 0.5625 18.3 18 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0117371405041608 0.0289964425996889 1.54510437375746 0.5625 18.3 18 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0117371405041608 0.0289964425996889 1.54510437375746 0.5625 18.3 18 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0117371405041608 0.0289964425996889 1.54510437375746 0.5625 18.3 18 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0117371405041608 0.0289964425996889 1.54510437375746 0.5625 18.3 18 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0117371405041608 0.0289964425996889 1.54510437375746 0.5625 18.3 18 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 9.85717431425882e-08 8.39925691568281e-07 1.54275261671977 0.561643835616438 18.3 18 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 6.50246326509022e-05 0.000322404363283045 1.54091709903183 0.560975609756098 18.3 18 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.69632508480407e-20 2.68207843964021e-18 1.53971536996259 0.560538116591928 18.3 18 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0018221246490677 0.00590634026337891 1.53823724320742 0.56 18.3 18 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0018221246490677 0.00590634026337891 1.53823724320742 0.56 18.3 18 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000299130385089307 0.00126309358451657 1.53500565236035 0.558823529411765 18.3 18 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000299130385089307 0.00126309358451657 1.53500565236035 0.558823529411765 18.3 18 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.52219358249565e-06 1.07231755836203e-05 1.53103238492542 0.557377049180328 18.3 18 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.18948922685402e-06 8.46321584906638e-06 1.52602901111847 0.555555555555556 18.3 18 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000231701036222259 0.000987157408815195 1.52602901111847 0.555555555555556 18.3 18 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00140147328991241 0.00479398195083021 1.52602901111847 0.555555555555556 18.3 18 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00140147328991241 0.00479398195083021 1.52602901111847 0.555555555555556 18.3 18 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00140147328991241 0.00479398195083021 1.52602901111847 0.555555555555556 18.3 18 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0632638857387578 0.119080038897159 1.52602901111847 0.555555555555556 18.3 18 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0632638857387578 0.119080038897159 1.52602901111847 0.555555555555556 18.3 18 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0632638857387578 0.119080038897159 1.52602901111847 0.555555555555556 18.3 18 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0632638857387578 0.119080038897159 1.52602901111847 0.555555555555556 18.3 18 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0632638857387578 0.119080038897159 1.52602901111847 0.555555555555556 18.3 18 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0632638857387578 0.119080038897159 1.52602901111847 0.555555555555556 18.3 18 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.28276818962842e-07 1.06747317768494e-06 1.51799727948101 0.552631578947368 18.3 18 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.78478802106741e-08 1.70453245233485e-07 1.51550467311076 0.551724137931034 18.3 18 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.78478802106741e-08 1.70453245233485e-07 1.51550467311076 0.551724137931034 18.3 18 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000138900857829163 0.000645326327229321 1.51076872100729 0.55 18.3 18 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000138900857829163 0.000645326327229321 1.51076872100729 0.55 18.3 18 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00675845925578376 0.0176140797087551 1.51076872100729 0.55 18.3 18 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.19581922928486e-09 1.36132061061788e-08 1.50548631289188 0.548076923076923 18.3 18 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00010751955356018 0.000510001082387122 1.50422859667392 0.547619047619048 18.3 18 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.72939971840231e-08 3.40188192261954e-07 1.50118667837934 0.546511627906977 18.3 18 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 8.32212466736433e-05 0.000398733447867321 1.49828302909814 0.545454545454545 18.3 18 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 8.32212466736433e-05 0.000398733447867321 1.49828302909814 0.545454545454545 18.3 18 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000638201828786533 0.00241507870019881 1.49828302909814 0.545454545454545 18.3 18 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00513984654926725 0.0141470051056234 1.49828302909814 0.545454545454545 18.3 18 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00513984654926725 0.0141470051056234 1.49828302909814 0.545454545454545 18.3 18 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0464169556694784 0.0935571216964133 1.49828302909814 0.545454545454545 18.3 18 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0464169556694784 0.0935571216964133 1.49828302909814 0.545454545454545 18.3 18 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0464169556694784 0.0935571216964133 1.49828302909814 0.545454545454545 18.3 18 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0464169556694784 0.0935571216964133 1.49828302909814 0.545454545454545 18.3 18 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0464169556694784 0.0935571216964133 1.49828302909814 0.545454545454545 18.3 18 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.0464169556694784 0.0935571216964133 1.49828302909814 0.545454545454545 18.3 18 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0464169556694784 0.0935571216964133 1.49828302909814 0.545454545454545 18.3 18 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0464169556694784 0.0935571216964133 1.49828302909814 0.545454545454545 18.3 18 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.27113051225872e-08 2.12619652562116e-07 1.4955084308961 0.544444444444444 18.3 18 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.6325006757593e-07 1.3428025789627e-06 1.49512209443759 0.544303797468354 18.3 18 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 6.44115860367283e-05 0.000322404363283045 1.49285446739851 0.543478260869565 18.3 18 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000491242522184387 0.00195808994136802 1.49114834800719 0.542857142857143 18.3 18 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00391418745967566 0.011367119908405 1.48787828584051 0.541666666666667 18.3 18 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00391418745967566 0.011367119908405 1.48787828584051 0.541666666666667 18.3 18 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000378236446508117 0.00153342012359274 1.48478498379095 0.540540540540541 18.3 18 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000378236446508117 0.00153342012359274 1.48478498379095 0.540540540540541 18.3 18 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 4.33112675252029e-07 3.31354482195504e-06 1.48185448711241 0.539473684210526 18.3 18 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00298454462401206 0.00882953638247227 1.47907427231483 0.538461538461538 18.3 18 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00298454462401206 0.00882953638247227 1.47907427231483 0.538461538461538 18.3 18 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0343315386183217 0.0722689045175618 1.47907427231483 0.538461538461538 18.3 18 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0343315386183217 0.0722689045175618 1.47907427231483 0.538461538461538 18.3 18 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0343315386183217 0.0722689045175618 1.47907427231483 0.538461538461538 18.3 18 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0343315386183217 0.0722689045175618 1.47907427231483 0.538461538461538 18.3 18 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0343315386183217 0.0722689045175618 1.47907427231483 0.538461538461538 18.3 18 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0343315386183217 0.0722689045175618 1.47907427231483 0.538461538461538 18.3 18 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0343315386183217 0.0722689045175618 1.47907427231483 0.538461538461538 18.3 18 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.65507254091588e-10 3.31418265414324e-09 1.4755817710815 0.537190082644628 18.3 18 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.65507254091588e-10 3.31418265414324e-09 1.4755817710815 0.537190082644628 18.3 18 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.41678737329569e-09 2.70794364740139e-08 1.47516137741453 0.537037037037037 18.3 18 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.0367912591913e-07 1.6467920237666e-06 1.47392070342175 0.536585365853659 18.3 18 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000224441750140833 0.000964896104079776 1.47392070342175 0.536585365853659 18.3 18 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000224441750140833 0.000964896104079776 1.47392070342175 0.536585365853659 18.3 18 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000224441750140833 0.000964896104079776 1.47392070342175 0.536585365853659 18.3 18 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000224441750140833 0.000964896104079776 1.47392070342175 0.536585365853659 18.3 18 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000224441750140833 0.000964896104079776 1.47392070342175 0.536585365853659 18.3 18 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00227832885740543 0.00698720250881019 1.4715279750071 0.535714285714286 18.3 18 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.38549234132195e-05 8.05308909634026e-05 1.46814515207605 0.53448275862069 18.3 18 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.07270234193682e-05 6.36023096906708e-05 1.46498785067374 0.533333333333333 18.3 18 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0255495645116774 0.0555917894497201 1.46498785067374 0.533333333333333 18.3 18 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0255495645116774 0.0555917894497201 1.46498785067374 0.533333333333333 18.3 18 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0255495645116774 0.0555917894497201 1.46498785067374 0.533333333333333 18.3 18 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.97533683290249e-09 3.23198802535897e-08 1.46003856739443 0.531531531531532 18.3 18 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00101965720294591 0.00360042729476931 1.45421588118349 0.529411764705882 18.3 18 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00101965720294591 0.00360042729476931 1.45421588118349 0.529411764705882 18.3 18 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0191069168148836 0.0436422835113635 1.45421588118349 0.529411764705882 18.3 18 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0191069168148836 0.0436422835113635 1.45421588118349 0.529411764705882 18.3 18 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.98841346505852e-06 1.96875572258253e-05 1.45190760200701 0.528571428571429 18.3 18 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.35965908505285e-37 4.83698719507553e-35 1.45175839764959 0.52851711026616 18.3 18 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.31501527534812e-06 1.58378208500979e-05 1.44972756056255 0.527777777777778 18.3 18 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 2.31501527534812e-06 1.58378208500979e-05 1.44972756056255 0.527777777777778 18.3 18 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000781318300612646 0.00285081010710717 1.44972756056255 0.527777777777778 18.3 18 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.6467877042153e-05 0.000195825618984844 1.44834026146153 0.527272727272727 18.3 18 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.6467877042153e-05 0.000195825618984844 1.44834026146153 0.527272727272727 18.3 18 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.79352373004643e-06 1.24496793553954e-05 1.44766535919617 0.527027027027027 18.3 18 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.79352373004643e-06 1.24496793553954e-05 1.44766535919617 0.527027027027027 18.3 18 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 7.03624720550285e-08 6.14268697756476e-07 1.44571169474382 0.526315789473684 18.3 18 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 7.03624720550285e-08 6.14268697756476e-07 1.44571169474382 0.526315789473684 18.3 18 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000599147527482916 0.00229779121458011 1.44571169474382 0.526315789473684 18.3 18 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.07409903919789e-30 1.15948858655572e-27 1.44435421897411 0.525821596244131 18.3 18 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.02553849387202e-09 1.17688812643539e-08 1.43988221210372 0.524193548387097 18.3 18 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.02553849387202e-09 1.17688812643539e-08 1.43988221210372 0.524193548387097 18.3 18 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.02553849387202e-09 1.17688812643539e-08 1.43988221210372 0.524193548387097 18.3 18 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 5.0124910328168e-07 3.75409196826226e-06 1.43882735334028 0.523809523809524 18.3 18 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 5.0124910328168e-07 3.75409196826226e-06 1.43882735334028 0.523809523809524 18.3 18 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.000353056166379554 0.00146046199057589 1.43882735334028 0.523809523809524 18.3 18 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0108062446499734 0.0272646917321138 1.43882735334028 0.523809523809524 18.3 18 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0108062446499734 0.0272646917321138 1.43882735334028 0.523809523809524 18.3 18 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0108062446499734 0.0272646917321138 1.43882735334028 0.523809523809524 18.3 18 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.54053036966041e-08 1.49127531702501e-07 1.43760490019385 0.523364485981308 18.3 18 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.00365567539137e-05 5.97574069490344e-05 1.43681500739155 0.523076923076923 18.3 18 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 7.75894517084228e-06 4.75904266297783e-05 1.43492280149946 0.522388059701492 18.3 18 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 7.75894517084228e-06 4.75904266297783e-05 1.43492280149946 0.522388059701492 18.3 18 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 7.13802689856638e-12 1.44672143606151e-10 1.43389141044717 0.522012578616352 18.3 18 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.3643916225788e-10 1.81451334479405e-09 1.43228722900691 0.521428571428571 18.3 18 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.58883361277414e-06 2.33192247989845e-05 1.42986827891101 0.520547945205479 18.3 18 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00618058883783426 0.0163475425952382 1.42836315440689 0.52 18.3 18 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00618058883783426 0.0163475425952382 1.42836315440689 0.52 18.3 18 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.00521746508329e-11 4.59830586324035e-10 1.42764029855952 0.519736842105263 18.3 18 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.48031517073871e-13 1.05372095488536e-11 1.42596153497956 0.519125683060109 18.3 18 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 7.321215556343e-05 0.000359244473678486 1.42429374371058 0.518518518518518 18.3 18 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00468939067611936 0.0132138671923126 1.42429374371058 0.518518518518518 18.3 18 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00468939067611936 0.0132138671923126 1.42429374371058 0.518518518518518 18.3 18 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00468939067611936 0.0132138671923126 1.42429374371058 0.518518518518518 18.3 18 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00468939067611936 0.0132138671923126 1.42429374371058 0.518518518518518 18.3 18 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00468939067611936 0.0132138671923126 1.42429374371058 0.518518518518518 18.3 18 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 4.34882336795719e-05 0.000230051139501973 1.42078563104134 0.517241379310345 18.3 18 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.00356438024052874 0.0103936743489189 1.42078563104134 0.517241379310345 18.3 18 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.35354012473191e-05 0.00018283860526795 1.41920698034018 0.516666666666667 18.3 18 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.11301866590878e-09 3.33943352359061e-08 1.41773017807136 0.516129032258065 18.3 18 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00271356650439234 0.00812927397000064 1.41773017807136 0.516129032258065 18.3 18 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00271356650439234 0.00812927397000064 1.41773017807136 0.516129032258065 18.3 18 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00271356650439234 0.00812927397000064 1.41773017807136 0.516129032258065 18.3 18 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.77069737705122e-11 4.28554605167814e-10 1.41716579503869 0.515923566878981 18.3 18 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.99616617257249e-05 0.000113621778542826 1.41634567594433 0.515625 18.3 18 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.10046547194995e-10 5.07388031876937e-09 1.41266685600682 0.514285714285714 18.3 18 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 9.18744650786896e-06 5.51634446442934e-05 1.41266685600682 0.514285714285714 18.3 18 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00157915510022282 0.00533679626368253 1.41266685600682 0.514285714285714 18.3 18 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 3.60976199552097e-08 3.31399439975893e-07 1.41122682863066 0.513761467889908 18.3 18 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 5.66255351956665e-15 3.83705412302064e-13 1.41088318573408 0.513636363636364 18.3 18 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.01177771283045e-08 1.02110615982818e-07 1.40805029765385 0.512605042016807 18.3 18 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.26242509627299e-11 4.88676938104891e-10 1.40776176275679 0.5125 18.3 18 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 7.84687358915978e-09 8.03316627149235e-08 1.40747799703158 0.512396694214876 18.3 18 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000541714937616915 0.00212944849786981 1.4053662520998 0.511627906976744 18.3 18 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 7.98552412247357e-10 9.46950068856657e-09 1.40306840015065 0.510791366906475 18.3 18 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.95224293659414e-07 1.58745239929912e-06 1.40089463220676 0.51 18.3 18 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.000188189523337044 0.000842118527385577 1.40035603373225 0.509803921568627 18.3 18 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.05069266541602e-10 1.43763044508366e-09 1.40000855084546 0.509677419354839 18.3 18 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 4.22081380878052e-08 3.81931882417e-07 1.39795157625675 0.508928571428571 18.3 18 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 6.48113583400104e-12 1.44672143606151e-10 1.39670451865081 0.508474576271186 18.3 18 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.18101612507118e-08 1.17523492725615e-07 1.39594129213788 0.508196721311475 18.3 18 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 5.0824233362395e-05 0.000263952131659445 1.39594129213788 0.508196721311475 18.3 18 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.0824233362395e-05 0.000263952131659445 1.39594129213788 0.508196721311475 18.3 18 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.91683817458883e-05 0.000209536117384959 1.39522652445118 0.507936507936508 18.3 18 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.38651217751466e-05 8.05308909634026e-05 1.39277013972503 0.507042253521127 18.3 18 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 4.93132543186856e-06 3.13271253997721e-05 1.39081125063962 0.506329113924051 18.3 18 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 2.94523883229636e-06 1.95351591051583e-05 1.38997341253683 0.506024096385542 18.3 18 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.30464487555184e-07 4.64845059995351e-06 1.38788322695407 0.505263157894737 18.3 18 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.09366040344269e-10 1.46818750386693e-09 1.38185203706188 0.503067484662577 18.3 18 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 4.75816704691846e-13 1.32762190348333e-11 1.37342611000663 0.5 18.3 18 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.55324461172598e-11 1.04352107596952e-09 1.37342611000663 0.5 18.3 18 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000166219605028705 0.000758110570371303 1.37342611000663 0.5 18.3 18 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000216185720376963 0.000950348276932097 1.37342611000663 0.5 18.3 18 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0013865837306362 0.00477750278134459 1.37342611000663 0.5 18.3 18 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00181443965462972 0.00590634026337891 1.37342611000663 0.5 18.3 18 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00538769086095156 0.0145477876568009 1.37342611000663 0.5 18.3 18 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00538769086095156 0.0145477876568009 1.37342611000663 0.5 18.3 18 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00538769086095156 0.0145477876568009 1.37342611000663 0.5 18.3 18 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00710045249483329 0.0184715610605992 1.37342611000663 0.5 18.3 18 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00937663305165649 0.024084745185031 1.37342611000663 0.5 18.3 18 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00937663305165649 0.024084745185031 1.37342611000663 0.5 18.3 18 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00937663305165649 0.024084745185031 1.37342611000663 0.5 18.3 18 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00937663305165649 0.024084745185031 1.37342611000663 0.5 18.3 18 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0219327312598312 0.0480897944264096 1.37342611000663 0.5 18.3 18 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0393619885191939 0.0810594929997292 1.37342611000663 0.5 18.3 18 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0393619885191939 0.0810594929997292 1.37342611000663 0.5 18.3 18 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0393619885191939 0.0810594929997292 1.37342611000663 0.5 18.3 18 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0393619885191939 0.0810594929997292 1.37342611000663 0.5 18.3 18 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0393619885191939 0.0810594929997292 1.37342611000663 0.5 18.3 18 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0531603665113608 0.104774517376269 1.37342611000663 0.5 18.3 18 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0531603665113608 0.104774517376269 1.37342611000663 0.5 18.3 18 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0531603665113608 0.104774517376269 1.37342611000663 0.5 18.3 18 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0531603665113608 0.104774517376269 1.37342611000663 0.5 18.3 18 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0531603665113608 0.104774517376269 1.37342611000663 0.5 18.3 18 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.09938849286885 0.173108721361534 1.37342611000663 0.5 18.3 18 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.09938849286885 0.173108721361534 1.37342611000663 0.5 18.3 18 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.09938849286885 0.173108721361534 1.37342611000663 0.5 18.3 18 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.09938849286885 0.173108721361534 1.37342611000663 0.5 18.3 18 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.09938849286885 0.173108721361534 1.37342611000663 0.5 18.3 18 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.09938849286885 0.173108721361534 1.37342611000663 0.5 18.3 18 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.09938849286885 0.173108721361534 1.37342611000663 0.5 18.3 18 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.09938849286885 0.173108721361534 1.37342611000663 0.5 18.3 18 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 9.42214905968199e-09 9.57694150851963e-08 1.37342611000663 0.5 18.3 18 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.06330059883148e-05 0.000116975169407856 1.37342611000663 0.5 18.3 18 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.57793704032487e-05 0.000370563725373962 1.37342611000663 0.5 18.3 18 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000477318293657428 0.00190793239290595 1.37342611000663 0.5 18.3 18 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.002376991899833 0.00721206710759563 1.37342611000663 0.5 18.3 18 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0031178517076172 0.00918572045536081 1.37342611000663 0.5 18.3 18 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0164726427506795 0.0389378249737824 1.37342611000663 0.5 18.3 18 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0164726427506795 0.0389378249737824 1.37342611000663 0.5 18.3 18 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0164726427506795 0.0389378249737824 1.37342611000663 0.5 18.3 18 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0164726427506795 0.0389378249737824 1.37342611000663 0.5 18.3 18 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0293141353729403 0.0626336556091503 1.37342611000663 0.5 18.3 18 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0293141353729403 0.0626336556091503 1.37342611000663 0.5 18.3 18 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0293141353729403 0.0626336556091503 1.37342611000663 0.5 18.3 18 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0723299970856918 0.132465361458094 1.37342611000663 0.5 18.3 18 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0723299970856918 0.132465361458094 1.37342611000663 0.5 18.3 18 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0723299970856918 0.132465361458094 1.37342611000663 0.5 18.3 18 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0723299970856918 0.132465361458094 1.37342611000663 0.5 18.3 18 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0723299970856918 0.132465361458094 1.37342611000663 0.5 18.3 18 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0723299970856918 0.132465361458094 1.37342611000663 0.5 18.3 18 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0723299970856918 0.132465361458094 1.37342611000663 0.5 18.3 18 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0723299970856918 0.132465361458094 1.37342611000663 0.5 18.3 18 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.17200266022699e-17 1.81809399147236e-15 1.36873864888032 0.498293515358362 18.3 18 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.43023202376661e-10 1.88156395633881e-09 1.36529932829061 0.497041420118343 18.3 18 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 4.94692096231243e-08 4.39966783085662e-07 1.36226004407161 0.495934959349593 18.3 18 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.95460519626175e-07 2.33577955237804e-06 1.36082587046528 0.495412844036697 18.3 18 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.81574088158026e-07 2.95097786656995e-06 1.36059035196918 0.495327102803738 18.3 18 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.20536289500278e-13 1.22127171420183e-11 1.35494952556708 0.493273542600897 18.3 18 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 3.02945388863563e-05 0.000165804341674173 1.35461205370517 0.493150684931507 18.3 18 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.87785586924581e-47 1.3360944509684e-44 1.3516750177667 0.492081447963801 18.3 18 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000187699648209867 0.000842118527385577 1.35014770136245 0.491525423728814 18.3 18 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000187699648209867 0.000842118527385577 1.35014770136245 0.491525423728814 18.3 18 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.58084573066623e-07 2.05170026521678e-06 1.34933091509423 0.491228070175439 18.3 18 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000317308807925879 0.0013202644259606 1.34845472618832 0.490909090909091 18.3 18 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.000317308807925879 0.0013202644259606 1.34845472618832 0.490909090909091 18.3 18 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000317308807925879 0.0013202644259606 1.34845472618832 0.490909090909091 18.3 18 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.000317308807925879 0.0013202644259606 1.34845472618832 0.490909090909091 18.3 18 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000412901065451319 0.00166919947766258 1.34751240981782 0.490566037735849 18.3 18 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 9.32058605950066e-15 4.91229406024794e-13 1.34711526498734 0.490421455938697 18.3 18 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.21289161415279e-06 4.48207195062857e-05 1.34221188023375 0.488636363636364 18.3 18 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 9.32983866994979e-06 5.57830270056242e-05 1.34148596791345 0.488372093023256 18.3 18 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 8.08414424682847e-08 6.92996220676923e-07 1.34098297354978 0.488188976377953 18.3 18 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00203392298347086 0.00632508470036133 1.33992791220159 0.48780487804878 18.3 18 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.38979044352481e-05 0.000183409574187673 1.33728331763803 0.486842105263158 18.3 18 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.95282922812141e-40 1.87495866387226e-37 1.33649659872604 0.486555697823303 18.3 18 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.77908437255871e-10 2.26039023406343e-09 1.33590080645453 0.486338797814208 18.3 18 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 5.68966950519035e-05 0.000291237399492297 1.33527538472866 0.486111111111111 18.3 18 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.87732899896892e-06 1.94973293596799e-05 1.33180713697612 0.484848484848485 18.3 18 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00600269503714785 0.0160241021003369 1.33180713697612 0.484848484848485 18.3 18 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00600269503714785 0.0160241021003369 1.33180713697612 0.484848484848485 18.3 18 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.34029800728267e-05 7.91387578573955e-05 1.32606658897192 0.482758620689655 18.3 18 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0104007865988508 0.0264764209841945 1.32606658897192 0.482758620689655 18.3 18 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0104007865988508 0.0264764209841945 1.32606658897192 0.482758620689655 18.3 18 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0137290724003695 0.0335102401813479 1.32255847630268 0.481481481481481 18.3 18 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0137290724003695 0.0335102401813479 1.32255847630268 0.481481481481481 18.3 18 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 6.79447850889289e-09 7.00619052040187e-08 1.32127068810764 0.481012658227848 18.3 18 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000774913996067665 0.00283471109615498 1.32060202885253 0.480769230769231 18.3 18 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.655177558333e-07 1.3536308422459e-06 1.32019253985133 0.48062015503876 18.3 18 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00100887026927548 0.00358010571865091 1.31848906560636 0.48 18.3 18 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.018162750174304 0.042231361924893 1.31848906560636 0.48 18.3 18 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.018162750174304 0.042231361924893 1.31848906560636 0.48 18.3 18 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00171338903641029 0.00560494850301574 1.31371193131069 0.478260869565217 18.3 18 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00171338903641029 0.00560494850301574 1.31371193131069 0.478260869565217 18.3 18 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.024090044350585 0.0526576545482066 1.31371193131069 0.478260869565217 18.3 18 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.000136592480761894 0.000639378618829524 1.31371193131069 0.478260869565217 18.3 18 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.07855316683631e-13 9.52343729653928e-12 1.31003721262171 0.476923076923077 18.3 18 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 7.24507543336554e-10 8.66364902662114e-09 1.30732538813465 0.475935828877005 18.3 18 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 7.49244834142025e-06 4.63554521297435e-05 1.30406115495579 0.474747474747475 18.3 18 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00498964587631397 0.0139494422043119 1.30114052526944 0.473684210526316 18.3 18 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0427858214765598 0.0874773332775066 1.30114052526944 0.473684210526316 18.3 18 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0427858214765598 0.0874773332775066 1.30114052526944 0.473684210526316 18.3 18 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0427858214765598 0.0874773332775066 1.30114052526944 0.473684210526316 18.3 18 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 7.81059174440117e-18 7.40964803485524e-16 1.29998086348221 0.473262032085562 18.3 18 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.95155250007662e-06 1.95351591051583e-05 1.29851195855172 0.472727272727273 18.3 18 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.000148852485307661 0.000683280924492908 1.2971246594507 0.472222222222222 18.3 18 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.057366496700803 0.112286829168147 1.29263633882977 0.470588235294118 18.3 18 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.057366496700803 0.112286829168147 1.29263633882977 0.470588235294118 18.3 18 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.057366496700803 0.112286829168147 1.29263633882977 0.470588235294118 18.3 18 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.057366496700803 0.112286829168147 1.29263633882977 0.470588235294118 18.3 18 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.06036463921553e-08 1.95459925440246e-07 1.28968061549403 0.469512195121951 18.3 18 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00041822967410645 0.00168118877472734 1.28758697813121 0.46875 18.3 18 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.00041822967410645 0.00168118877472734 1.28758697813121 0.46875 18.3 18 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 5.26718643797209e-12 1.27037394936174e-10 1.28622445222843 0.468253968253968 18.3 18 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 5.26718643797209e-12 1.27037394936174e-10 1.28622445222843 0.468253968253968 18.3 18 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 5.26718643797209e-12 1.27037394936174e-10 1.28622445222843 0.468253968253968 18.3 18 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.33992157296315e-07 1.87062269568908e-06 1.28576061362323 0.468085106382979 18.3 18 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0773198182610837 0.140160638707672 1.28186436933952 0.466666666666667 18.3 18 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0773198182610837 0.140160638707672 1.28186436933952 0.466666666666667 18.3 18 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0773198182610837 0.140160638707672 1.28186436933952 0.466666666666667 18.3 18 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 6.21591134716978e-05 0.000317033757957799 1.27760568372709 0.465116279069767 18.3 18 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00410352398413145 0.0118926978195907 1.27760568372709 0.465116279069767 18.3 18 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.019473876318501 0.044338121601963 1.27532424500615 0.464285714285714 18.3 18 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.019473876318501 0.044338121601963 1.27532424500615 0.464285714285714 18.3 18 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 3.76488589819058e-09 3.96846861712978e-08 1.27328045615198 0.463541666666667 18.3 18 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000103397787734451 0.000492090474736201 1.27293151659151 0.463414634146341 18.3 18 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.3690541406874e-07 1.13265351290591e-06 1.26777794769842 0.461538461538462 18.3 18 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000172050901850117 0.000779708386409924 1.26777794769842 0.461538461538462 18.3 18 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0256937077080019 0.0556501462229629 1.26777794769842 0.461538461538462 18.3 18 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0256937077080019 0.0556501462229629 1.26777794769842 0.461538461538462 18.3 18 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0256937077080019 0.0556501462229629 1.26777794769842 0.461538461538462 18.3 18 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.104900104343438 0.181376486610829 1.26777794769842 0.461538461538462 18.3 18 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.104900104343438 0.181376486610829 1.26777794769842 0.461538461538462 18.3 18 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.104900104343438 0.181376486610829 1.26777794769842 0.461538461538462 18.3 18 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.104900104343438 0.181376486610829 1.26777794769842 0.461538461538462 18.3 18 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00258008364612603 0.00777851489075709 1.2635520212061 0.46 18.3 18 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00011023531005949 0.000519420020578325 1.26032043035902 0.458823529411765 18.3 18 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00011023531005949 0.000519420020578325 1.26032043035902 0.458823529411765 18.3 18 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 5.21079920561231e-12 1.27037394936174e-10 1.25938711892304 0.458483754512635 18.3 18 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0339720480271737 0.0722604250264099 1.25897393417274 0.458333333333333 18.3 18 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0339720480271737 0.0722604250264099 1.25897393417274 0.458333333333333 18.3 18 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 5.49092581602437e-05 0.000282078968815981 1.25653878149542 0.457446808510638 18.3 18 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0119319981547814 0.0294267476156915 1.25570387200606 0.457142857142857 18.3 18 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000182843156695531 0.000825986704691239 1.25473496469741 0.45679012345679 18.3 18 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00435418770456435 0.0123920182071901 1.25399775261475 0.456521739130435 18.3 18 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00435418770456435 0.0123920182071901 1.25399775261475 0.456521739130435 18.3 18 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.0590065639507e-06 7.62509839951397e-06 1.24856919091512 0.454545454545455 18.3 18 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000794254130446519 0.00288840453845037 1.24856919091512 0.454545454545455 18.3 18 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00566034607981114 0.015255061499188 1.24856919091512 0.454545454545455 18.3 18 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0156173500782533 0.0371630253534356 1.24856919091512 0.454545454545455 18.3 18 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0156173500782533 0.0371630253534356 1.24856919091512 0.454545454545455 18.3 18 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0156173500782533 0.0371630253534356 1.24856919091512 0.454545454545455 18.3 18 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.143531440534993 0.232641733426616 1.24856919091512 0.454545454545455 18.3 18 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 2.52043663817258e-13 7.97018074693239e-12 1.2470372041778 0.45398773006135 18.3 18 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00132335624760392 0.00460424435291046 1.24051390581244 0.451612903225806 18.3 18 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0204634736601019 0.045518049894534 1.24051390581244 0.451612903225806 18.3 18 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.65694429069215e-06 2.9716734195762e-05 1.23713191588383 0.450381679389313 18.3 18 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.65694429069215e-06 2.9716734195762e-05 1.23713191588383 0.450381679389313 18.3 18 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.00958013613188595 0.0245189455317873 1.23608349900596 0.45 18.3 18 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00958013613188595 0.0245189455317873 1.23608349900596 0.45 18.3 18 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0598474407447924 0.116010975190319 1.23608349900596 0.45 18.3 18 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0598474407447924 0.116010975190319 1.23608349900596 0.45 18.3 18 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0598474407447924 0.116010975190319 1.23608349900596 0.45 18.3 18 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0598474407447924 0.116010975190319 1.23608349900596 0.45 18.3 18 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000157814039210181 0.000722088031498674 1.23454032360146 0.449438202247191 18.3 18 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.000834404153049169 0.00300596736655435 1.23409302638277 0.449275362318841 18.3 18 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00220556155877758 0.00679332055874567 1.23134754690249 0.448275862068966 18.3 18 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00220556155877758 0.00679332055874567 1.23134754690249 0.448275862068966 18.3 18 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00220556155877758 0.00679332055874567 1.23134754690249 0.448275862068966 18.3 18 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 4.99715952562117e-05 0.000261432279594078 1.2295433746726 0.447619047619048 18.3 18 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00138379782584354 0.00477750278134459 1.22551868277514 0.446153846153846 18.3 18 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.00969923956463e-06 7.3306225403085e-06 1.22471118089763 0.445859872611465 18.3 18 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000333582443258643 0.00138392949491851 1.22450038723482 0.44578313253012 18.3 18 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.70102280354365e-19 3.20296287453551e-17 1.22425248757145 0.445692883895131 18.3 18 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 8.43655449634899e-54 1.20052170483046e-50 1.22180837933449 0.444803098773402 18.3 18 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.000211424509247288 0.000937249459996544 1.22082320889478 0.444444444444444 18.3 18 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00766973838055176 0.0199161272181116 1.22082320889478 0.444444444444444 18.3 18 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0352654159541076 0.0740157623933556 1.22082320889478 0.444444444444444 18.3 18 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0798083857630933 0.143212273569838 1.22082320889478 0.444444444444444 18.3 18 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0798083857630933 0.143212273569838 1.22082320889478 0.444444444444444 18.3 18 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0798083857630933 0.143212273569838 1.22082320889478 0.444444444444444 18.3 18 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.80626308731914e-08 2.61000808709486e-07 1.21646312600587 0.442857142857143 18.3 18 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00111861490628373 0.0039206625902506 1.21646312600587 0.442857142857143 18.3 18 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00229440460445193 0.00702137150996795 1.21581983508783 0.442622950819672 18.3 18 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00474744006151442 0.0133246690483925 1.21495386654432 0.442307692307692 18.3 18 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00474744006151442 0.0133246690483925 1.21495386654432 0.442307692307692 18.3 18 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0211834157566485 0.0466625396620911 1.21184656765291 0.441176470588235 18.3 18 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0211834157566485 0.0466625396620911 1.21184656765291 0.441176470588235 18.3 18 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0211834157566485 0.0466625396620911 1.21184656765291 0.441176470588235 18.3 18 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0211834157566485 0.0466625396620911 1.21184656765291 0.441176470588235 18.3 18 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000139223599760648 0.000645326327229321 1.20861497680583 0.44 18.3 18 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0128891874829223 0.031732376796191 1.20593512098143 0.439024390243902 18.3 18 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.106842574726998 0.184510902714221 1.2017478462558 0.4375 18.3 18 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00791530984689833 0.0205163677816691 1.2017478462558 0.4375 18.3 18 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00489483259448608 0.013711312562901 1.19862642327851 0.436363636363636 18.3 18 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000586275917455517 0.00227121920639063 1.19568861341753 0.435294117647059 18.3 18 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000586275917455517 0.00227121920639063 1.19568861341753 0.435294117647059 18.3 18 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000586275917455517 0.00227121920639063 1.19568861341753 0.435294117647059 18.3 18 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000586275917455517 0.00227121920639063 1.19568861341753 0.435294117647059 18.3 18 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000586275917455517 0.00227121920639063 1.19568861341753 0.435294117647059 18.3 18 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.061132260918479 0.116298405463898 1.19428357391881 0.434782608695652 18.3 18 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0360669800981079 0.0751439424298793 1.19030262867241 0.433333333333333 18.3 18 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0216786473065678 0.0476796215104266 1.18782798703276 0.432432432432432 18.3 18 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000956054983187642 0.00340116560269004 1.18691145309215 0.432098765432099 18.3 18 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000601748171258364 0.00229779121458011 1.18614073136936 0.431818181818182 18.3 18 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.20385572505788e-17 1.07067918547336e-15 1.18340743629293 0.430823117338003 18.3 18 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0170346045009047 0.0401994066414385 1.17722238000568 0.428571428571429 18.3 18 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0471090706808127 0.0938196095389038 1.17722238000568 0.428571428571429 18.3 18 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.143704907717495 0.232641733426616 1.17722238000568 0.428571428571429 18.3 18 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.143704907717495 0.232641733426616 1.17722238000568 0.428571428571429 18.3 18 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.143704907717495 0.232641733426616 1.17722238000568 0.428571428571429 18.3 18 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 9.09083031750532e-15 4.91229406024794e-13 1.17243692317639 0.426829268292683 18.3 18 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000795681362665176 0.00288840453845037 1.16442648457084 0.423913043478261 18.3 18 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0135364083085997 0.0331537160467081 1.15367793240557 0.42 18.3 18 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00203830442471627 0.00632508470036133 1.15299969728951 0.419753086419753 18.3 18 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.74570894556653e-05 0.000151439683315549 1.15190576968298 0.419354838709677 18.3 18 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0221415938304713 0.048473058493478 1.14984511535439 0.418604651162791 18.3 18 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.68854624175163e-17 2.91600072334031e-15 1.14914968457786 0.418351477449456 18.3 18 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0106531184375087 0.0270220811703652 1.14868365564191 0.418181818181818 18.3 18 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0173290088052732 0.040424884475252 1.14452175833886 0.416666666666667 18.3 18 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.036601785363018 0.0760355336811308 1.14452175833886 0.416666666666667 18.3 18 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.080532412983697 0.144147954309183 1.14452175833886 0.416666666666667 18.3 18 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.080532412983697 0.144147954309183 1.14452175833886 0.416666666666667 18.3 18 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.194389614427351 0.304643635826124 1.14452175833886 0.416666666666667 18.3 18 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.194389614427351 0.304643635826124 1.14452175833886 0.416666666666667 18.3 18 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.194389614427351 0.304643635826124 1.14452175833886 0.416666666666667 18.3 18 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.194389614427351 0.304643635826124 1.14452175833886 0.416666666666667 18.3 18 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.194389614427351 0.304643635826124 1.14452175833886 0.416666666666667 18.3 18 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.194389614427351 0.304643635826124 1.14452175833886 0.416666666666667 18.3 18 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0614125828914689 0.116675708217036 1.13662850483307 0.413793103448276 18.3 18 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.42900159736402e-11 2.4499629795771e-10 1.13323051229246 0.412556053811659 18.3 18 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.53218931614112e-24 7.18043628124116e-22 1.13283595059606 0.412412412412412 18.3 18 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.4397321313813e-07 2.68941693568989e-06 1.13105679647605 0.411764705882353 18.3 18 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00664483546347904 0.0174457580526396 1.13105679647605 0.411764705882353 18.3 18 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0471953523601285 0.0938196095389038 1.13105679647605 0.411764705882353 18.3 18 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.141475829345334 0.232203120136575 1.13105679647605 0.411764705882353 18.3 18 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.141475829345334 0.232203120136575 1.13105679647605 0.411764705882353 18.3 18 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.141475829345334 0.232203120136575 1.13105679647605 0.411764705882353 18.3 18 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.141475829345334 0.232203120136575 1.13105679647605 0.411764705882353 18.3 18 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.141475829345334 0.232203120136575 1.13105679647605 0.411764705882353 18.3 18 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.141475829345334 0.232203120136575 1.13105679647605 0.411764705882353 18.3 18 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.141475829345334 0.232203120136575 1.13105679647605 0.411764705882353 18.3 18 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0364838824878354 0.0759014104973535 1.12691373128749 0.41025641025641 18.3 18 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0608181219198718 0.116010975190319 1.11590871438038 0.40625 18.3 18 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0608181219198718 0.116010975190319 1.11590871438038 0.40625 18.3 18 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.00522263490219031 0.0142003140332588 1.1126490005117 0.40506329113924 18.3 18 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.021925161958078 0.0480897944264096 1.10930570423612 0.403846153846154 18.3 18 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0171513329388643 0.0402471768993403 1.10837896597026 0.403508771929825 18.3 18 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0277922000344968 0.0596505288824871 1.0987408880053 0.4 18.3 18 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.103291595507971 0.179467570705547 1.0987408880053 0.4 18.3 18 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.103291595507971 0.179467570705547 1.0987408880053 0.4 18.3 18 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00161266506913808 0.00533679626368253 1.0987408880053 0.4 18.3 18 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0783096514203762 0.141774343474803 1.0987408880053 0.4 18.3 18 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.137991517940789 0.229256803492792 1.0987408880053 0.4 18.3 18 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.18796163402177 0.296529274072038 1.0987408880053 0.4 18.3 18 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.18796163402177 0.296529274072038 1.0987408880053 0.4 18.3 18 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.18796163402177 0.296529274072038 1.0987408880053 0.4 18.3 18 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0351795219074963 0.0739445490020196 1.08729567042191 0.395833333333333 18.3 18 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.35916398305075e-05 7.95921953860583e-05 1.08459400961897 0.394849785407725 18.3 18 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0766349404599308 0.139452071962253 1.0820932987931 0.393939393939394 18.3 18 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0444589574324763 0.0906376739633436 1.07485521652693 0.391304347826087 18.3 18 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.133844760107307 0.224865517866232 1.07485521652693 0.391304347826087 18.3 18 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0206815665830411 0.0458409178312579 1.07298914844268 0.390625 18.3 18 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0574867282935575 0.112367602145237 1.07194232976127 0.390243902439024 18.3 18 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.00607428055542265 0.016126308265609 1.06982665411043 0.389473684210526 18.3 18 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0434696263309565 0.0887478884776916 1.06510596286228 0.387755102040816 18.3 18 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.000216860600152992 0.000950348276932097 1.05868262646344 0.385416666666667 18.3 18 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0424187849749436 0.0871023535632681 1.05648162308202 0.384615384615385 18.3 18 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0727132118652881 0.132655000620904 1.05648162308202 0.384615384615385 18.3 18 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0727132118652881 0.132655000620904 1.05648162308202 0.384615384615385 18.3 18 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0727132118652881 0.132655000620904 1.05648162308202 0.384615384615385 18.3 18 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.129365349602894 0.217596799627563 1.05648162308202 0.384615384615385 18.3 18 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.250320558229797 0.377737173235421 1.05648162308202 0.384615384615385 18.3 18 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.250320558229797 0.377737173235421 1.05648162308202 0.384615384615385 18.3 18 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0149374977810586 0.0360272192244854 1.05126442988162 0.382716049382716 18.3 18 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0314622016454017 0.0671225081580309 1.04641989333838 0.380952380952381 18.3 18 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.124746226349095 0.210324502481946 1.04190946276365 0.379310344827586 18.3 18 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0684362467921003 0.128137867348893 1.03769972756056 0.377777777777778 18.3 18 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0515265240656543 0.102262543578 1.03654800755217 0.377358490566038 18.3 18 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.0390707920951818 0.0810462640691599 1.03569837803778 0.377049180327869 18.3 18 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0662591564193531 0.1242250060405 1.03006958250497 0.375 18.3 18 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0662591564193531 0.1242250060405 1.03006958250497 0.375 18.3 18 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.165832168381474 0.266944768786015 1.03006958250497 0.375 18.3 18 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.165832168381474 0.266944768786015 1.03006958250497 0.375 18.3 18 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.236633069598633 0.358222189403037 1.03006958250497 0.375 18.3 18 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.236633069598633 0.358222189403037 1.03006958250497 0.375 18.3 18 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.236633069598633 0.358222189403037 1.03006958250497 0.375 18.3 18 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.00989488603702598 0.0252790356026714 1.02686064299561 0.373831775700935 18.3 18 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00252383127521768 0.0076250783537893 1.0192722074263 0.371069182389937 18.3 18 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00252383127521768 0.0076250783537893 1.0192722074263 0.371069182389937 18.3 18 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000894344242435376 0.00321376731562005 1.01786909675618 0.370558375634518 18.3 18 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.223876583528855 0.339996134857589 1.01199818632067 0.368421052631579 18.3 18 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 4.80671778552207e-07 3.65773230417e-06 1.00995374554023 0.367676767676768 18.3 18 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0794917867932611 0.143185838742798 1.00904775429058 0.36734693877551 18.3 18 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.151630559202564 0.244637512182821 1.00717914733819 0.366666666666667 18.3 18 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.144943585006413 0.234114326292992 0.998855352732092 0.363636363636364 18.3 18 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.144943585006413 0.234114326292992 0.998855352732092 0.363636363636364 18.3 18 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.21202525265524 0.323032049816281 0.998855352732092 0.363636363636364 18.3 18 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.21202525265524 0.323032049816281 0.998855352732092 0.363636363636364 18.3 18 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.21202525265524 0.323032049816281 0.998855352732092 0.363636363636364 18.3 18 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.138552952216304 0.229256803492792 0.991918857227008 0.361111111111111 18.3 18 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00432306478981993 0.0123920182071901 0.990144404888499 0.36046511627907 18.3 18 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.20101124062282 0.307238448341861 0.988866799204771 0.36 18.3 18 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.20101124062282 0.307238448341861 0.988866799204771 0.36 18.3 18 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.20101124062282 0.307238448341861 0.988866799204771 0.36 18.3 18 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.20101124062282 0.307238448341861 0.988866799204771 0.36 18.3 18 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.060788503091665 0.116010975190319 0.981018650004734 0.357142857142857 18.3 18 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.126651677210641 0.213284422095554 0.981018650004734 0.357142857142857 18.3 18 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.309551475181076 0.440491749182671 0.981018650004734 0.357142857142857 18.3 18 3 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.309551475181076 0.440491749182671 0.981018650004734 0.357142857142857 18.3 18 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.309551475181076 0.440491749182671 0.981018650004734 0.357142857142857 18.3 18 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.309551475181076 0.440491749182671 0.981018650004734 0.357142857142857 18.3 18 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.115862850847426 0.199603918590663 0.972843494588027 0.354166666666667 18.3 18 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00912447780407879 0.0236075125730984 0.972488053048171 0.354037267080745 18.3 18 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.288537018827705 0.415896589518319 0.969477254122325 0.352941176470588 18.3 18 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0104833301422131 0.0266388907006593 0.966485040375034 0.351851851851852 18.3 18 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0153111898793006 0.0368660291002448 0.956967870198166 0.348387096774194 18.3 18 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00345457322729381 0.0101567307901634 0.947933315141829 0.345098039215686 18.3 18 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0610992675215252 0.116298405463898 0.945153452047571 0.344086021505376 18.3 18 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.213199353238418 0.324126794506697 0.944230450629556 0.34375 18.3 18 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.213199353238418 0.324126794506697 0.944230450629556 0.34375 18.3 18 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0900686195500523 0.158819883047986 0.939712601583482 0.342105263157895 18.3 18 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0791253860230926 0.142887594303123 0.937161345651581 0.341176470588235 18.3 18 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0791253860230926 0.142887594303123 0.937161345651581 0.341176470588235 18.3 18 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0758190890179425 0.13814412762168 0.936426893186336 0.340909090909091 18.3 18 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.279110366734506 0.409020080970537 0.915617406671085 0.333333333333333 18.3 18 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.31855881208167 0.451619694964612 0.915617406671085 0.333333333333333 18.3 18 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.31855881208167 0.451619694964612 0.915617406671085 0.333333333333333 18.3 18 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.24732723735442 0.374013452449883 0.915617406671084 0.333333333333333 18.3 18 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0401568267394127 0.0825768272401508 0.910000121967581 0.331288343558282 18.3 18 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0532661809564966 0.104837863763616 0.90916939676495 0.330985915492958 18.3 18 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0959804406605955 0.168825917255905 0.906461232604374 0.33 18.3 18 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0618657585543056 0.117379965897036 0.902537158004355 0.328571428571429 18.3 18 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0644698374530528 0.121189668026016 0.902250729201434 0.328467153284672 18.3 18 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0794341387472271 0.143185838742798 0.900607285250247 0.327868852459016 18.3 18 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.266956200672976 0.394884276047447 0.890870990274569 0.324324324324324 18.3 18 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.301125635394095 0.430222669845177 0.886081361294598 0.32258064516129 18.3 18 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.301125635394095 0.430222669845177 0.886081361294598 0.32258064516129 18.3 18 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0914335666802147 0.161027184883596 0.882200712996957 0.321167883211679 18.3 18 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.115245123875679 0.198780377303142 0.868490040151249 0.316176470588235 18.3 18 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0578537228954452 0.112929832208805 0.860459731570417 0.313253012048193 18.3 18 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.431125180379864 0.589328656753646 0.858391318754142 0.3125 18.3 18 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.318641021605391 0.451619694964612 0.850216163337436 0.30952380952381 18.3 18 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.315984566724211 0.449196841606945 0.840873128575486 0.306122448979592 18.3 18 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.381859470730264 0.532209624729839 0.832379460610077 0.303030303030303 18.3 18 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.329822739557677 0.467002744667239 0.829238406041737 0.30188679245283 18.3 18 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.407407326619057 0.557979428083656 0.824055666003976 0.3 18.3 18 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.407407326619057 0.557979428083656 0.824055666003976 0.3 18.3 18 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.451619792970051 0.611726695418732 0.824055666003976 0.3 18.3 18 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.451619792970051 0.611726695418732 0.824055666003976 0.3 18.3 18 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.451619792970051 0.611726695418732 0.824055666003976 0.3 18.3 18 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.397642363279846 0.553123248237753 0.816631741085021 0.297297297297297 18.3 18 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.490536914359931 0.643942831304596 0.807897711768604 0.294117647058824 18.3 18 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.468101770036553 0.617339034997234 0.801165230837199 0.291666666666667 18.3 18 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.392663807753838 0.546732483790324 0.799084282185674 0.290909090909091 18.3 18 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.450886200301997 0.611726695418732 0.797473225165138 0.290322580645161 18.3 18 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.450886200301997 0.611726695418732 0.797473225165138 0.290322580645161 18.3 18 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.463931857119144 0.612975889211274 0.784814920003787 0.285714285714286 18.3 18 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.481920155676943 0.634374222531471 0.784814920003787 0.285714285714286 18.3 18 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.49384909843985 0.6476933337142 0.772552186878728 0.28125 18.3 18 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.465705231814312 0.614748186337446 0.76551619246271 0.278688524590164 18.3 18 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.135598992933326 0.227544064792597 0.762418982042703 0.277560975609756 18.3 18 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.420808063820478 0.575778725785135 0.757240341733384 0.275675675675676 18.3 18 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.445592355909725 0.608520079135833 0.757006517326487 0.275590551181102 18.3 18 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.482356225424492 0.634374222531471 0.756379596815244 0.27536231884058 18.3 18 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.485895659220367 0.638439079474222 0.749141514549069 0.272727272727273 18.3 18 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.512238881125049 0.663857857778639 0.749141514549069 0.272727272727273 18.3 18 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.55605782739218 0.710296488670622 0.749141514549069 0.272727272727273 18.3 18 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.53024218253686 0.68221937228748 0.743939142920256 0.270833333333333 18.3 18 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.563567114445693 0.719243052785849 0.739537136157414 0.269230769230769 18.3 18 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.564264048553325 0.719487223200163 0.728756711432088 0.26530612244898 18.3 18 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.601182158846051 0.745971608710931 0.722855847371909 0.263157894736842 18.3 18 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.592545388918925 0.745971608710931 0.716570144351284 0.260869565217391 18.3 18 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.60365220248838 0.745971608710931 0.713125095580364 0.259615384615385 18.3 18 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.625839788141851 0.769723438656745 0.701323971067214 0.25531914893617 18.3 18 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.650345919250075 0.799172921496422 0.686713055003313 0.25 18.3 18 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.687449850189951 0.835389527600599 0.671452764892129 0.244444444444444 18.3 18 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.688104182254097 0.835471204221484 0.665903568488061 0.242424242424242 18.3 18 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.689632510579169 0.836613011555122 0.663033294485958 0.241379310344828 18.3 18 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.779840887710479 0.916960382246759 0.651315474848503 0.237113402061856 18.3 18 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.846535403495806 0.966014337750226 0.649792998282705 0.236559139784946 18.3 18 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.722448441516921 0.86245313110619 0.646318169414883 0.235294117647059 18.3 18 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.902632731401095 1 0.619716659393234 0.225609756097561 18.3 18 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.813783867359339 0.940710351951535 0.61041160444739 0.222222222222222 18.3 18 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.886075049931025 1 0.580320891552096 0.211267605633803 18.3 18 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.83354428149761 0.961932073187613 0.578284677897527 0.210526315789474 18.3 18 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.850598895390548 0.969873580240985 0.549370444002651 0.2 18.3 18 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.862246647875019 0.981581583940922 0.52824081154101 0.192307692307692 18.3 18 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.919585403338238 1 0.511042273490838 0.186046511627907 18.3 18 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.90295064513723 1 0.490509325002367 0.178571428571429 18.3 18 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.977235246961295 1 0.486783937723868 0.177215189873418 18.3 18 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.935098996436097 1 0.470888952002272 0.171428571428571 18.3 18 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.96564229875838 1 0.466446603398477 0.169811320754717 18.3 18 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.944320850311491 1 0.443040680647299 0.161290322580645 18.3 18 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.944320850311491 1 0.443040680647299 0.161290322580645 18.3 18 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999999852082 1 0.375214349640986 0.13659793814433 18.3 18 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.359789207659167 0.130982367758186 18.3 18 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999999758723706 1 0.354432544517839 0.129032258064516 18.3 18 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.99483872916888 1 0.343356527501657 0.125 18.3 18 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999999909871 1 0.313925968001515 0.114285714285714 18.3 18 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.99998046449971 1 0.305205802223695 0.111111111111111 18.3 18 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.288096616203922 0.104882459312839 18.3 18 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999984100819 1 0.280928067955901 0.102272727272727 18.3 18 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999994180115596 1 0.244164641778956 0.0888888888888889 18.3 18 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.000744715120660026 0.00228390003598969 1.79762493814943 1 18.2 18 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000744715120660026 0.00228390003598969 1.79762493814943 1 18.2 18 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.000744715120660026 0.00228390003598969 1.79762493814943 1 18.2 18 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000744715120660026 0.00228390003598969 1.79762493814943 1 18.2 18 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.000744715120660026 0.00228390003598969 1.79762493814943 1 18.2 18 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 4.33517457912795e-06 1.98358631064279e-05 1.79762493814943 1 18.2 18 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 4.33517457912795e-06 1.98358631064279e-05 1.79762493814943 1 18.2 18 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 9.50748934696266e-05 0.000354166422532143 1.79762493814943 1 18.2 18 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.000266096722802101 0.000897288238263956 1.79762493814943 1 18.2 18 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.000266096722802101 0.000897288238263956 1.79762493814943 1 18.2 18 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.000266096722802101 0.000897288238263956 1.79762493814943 1 18.2 18 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.000266096722802101 0.000897288238263956 1.79762493814943 1 18.2 18 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000266096722802101 0.000897288238263956 1.79762493814943 1 18.2 18 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00208409632529264 0.00567049535543293 1.79762493814943 1 18.2 18 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00208409632529264 0.00567049535543293 1.79762493814943 1 18.2 18 2 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.00583206527989447 0.0140900320768928 1.79762493814943 1 18.2 18 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.59058079270846e-08 1.19756426879584e-07 1.71202375061851 0.952380952380952 18.2 18 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 4.247573656023e-08 3.03733533292499e-07 1.70774369124196 0.95 18.2 18 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.68272630491903e-13 3.1926927091997e-12 1.69775688603002 0.944444444444444 18.2 18 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 3.00640240585843e-07 1.81275873878667e-06 1.69775688603002 0.944444444444444 18.2 18 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 7.96405082530591e-07 4.16648688397438e-06 1.69188229472888 0.941176470588235 18.2 18 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 1.44893766198326e-05 5.97634287826717e-05 1.66922315685304 0.928571428571429 18.2 18 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 3.7774005249981e-05 0.000148487318979898 1.65934609675332 0.923076923076923 18.2 18 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 3.7774005249981e-05 0.000148487318979898 1.65934609675332 0.923076923076923 18.2 18 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.75201764707394e-08 1.31216900620328e-07 1.64782285997031 0.916666666666667 18.2 18 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 9.7936299276608e-05 0.000361982737326268 1.64782285997031 0.916666666666667 18.2 18 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 9.7936299276608e-05 0.000361982737326268 1.64782285997031 0.916666666666667 18.2 18 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 9.7936299276608e-05 0.000361982737326268 1.64782285997031 0.916666666666667 18.2 18 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 1.15533048070896e-07 7.57619941957997e-07 1.63420448922676 0.909090909090909 18.2 18 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000252294591791607 0.00088427390177206 1.63420448922676 0.909090909090909 18.2 18 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.000252294591791607 0.00088427390177206 1.63420448922676 0.909090909090909 18.2 18 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.9489005857511e-07 1.78565341852077e-06 1.62642256308758 0.904761904761905 18.2 18 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 7.49269193249404e-07 3.93435447230222e-06 1.61786244433449 0.9 18.2 18 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 7.49269193249404e-07 3.93435447230222e-06 1.61786244433449 0.9 18.2 18 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 7.49269193249404e-07 3.93435447230222e-06 1.61786244433449 0.9 18.2 18 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000645037528016531 0.00201291316308667 1.61786244433449 0.9 18.2 18 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000645037528016531 0.00201291316308667 1.61786244433449 0.9 18.2 18 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000645037528016531 0.00201291316308667 1.61786244433449 0.9 18.2 18 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.000645037528016531 0.00201291316308667 1.61786244433449 0.9 18.2 18 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 9.72543900472835e-10 9.67783196064926e-09 1.61786244433449 0.9 18.2 18 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 8.42643889645691e-12 1.2756194201764e-10 1.60840126044949 0.894736842105263 18.2 18 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 1.89426408661776e-06 9.29495791467956e-06 1.60840126044949 0.894736842105263 18.2 18 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 5.30086623295312e-11 7.34000287150325e-10 1.59788883391061 0.888888888888889 18.2 18 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 4.76252381808859e-06 2.1446428459304e-05 1.59788883391061 0.888888888888889 18.2 18 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 4.76252381808859e-06 2.1446428459304e-05 1.59788883391061 0.888888888888889 18.2 18 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 4.76252381808859e-06 2.1446428459304e-05 1.59788883391061 0.888888888888889 18.2 18 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00163427135746189 0.00456889615258993 1.59788883391061 0.888888888888889 18.2 18 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00163427135746189 0.00456889615258993 1.59788883391061 0.888888888888889 18.2 18 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00163427135746189 0.00456889615258993 1.59788883391061 0.888888888888889 18.2 18 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 9.62381760308053e-08 6.43767967182871e-07 1.5819099455715 0.88 18.2 18 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 9.62381760308053e-08 6.43767967182871e-07 1.5819099455715 0.88 18.2 18 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0040950439056655 0.0102773324122787 1.57292182088075 0.875 18.2 18 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0040950439056655 0.0102773324122787 1.57292182088075 0.875 18.2 18 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0040950439056655 0.0102773324122787 1.57292182088075 0.875 18.2 18 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0040950439056655 0.0102773324122787 1.57292182088075 0.875 18.2 18 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0040950439056655 0.0102773324122787 1.57292182088075 0.875 18.2 18 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 5.85244345101943e-07 3.17863627129796e-06 1.56315212012994 0.869565217391304 18.2 18 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.85244345101943e-07 3.17863627129796e-06 1.56315212012994 0.869565217391304 18.2 18 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.2108929587296e-08 9.41585071187007e-08 1.55794161306284 0.866666666666667 18.2 18 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0101203835530883 0.0228955577043635 1.54082137555666 0.857142857142857 18.2 18 2 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0101203835530883 0.0228955577043635 1.54082137555666 0.857142857142857 18.2 18 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0101203835530883 0.0228955577043635 1.54082137555666 0.857142857142857 18.2 18 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0101203835530883 0.0228955577043635 1.54082137555666 0.857142857142857 18.2 18 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0101203835530883 0.0228955577043635 1.54082137555666 0.857142857142857 18.2 18 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.07659115097628e-12 6.74533628818517e-11 1.52989356438249 0.851063829787234 18.2 18 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 8.38256848237182e-06 3.58210058571024e-05 1.52798119742702 0.85 18.2 18 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.1255628283551e-07 2.40601471506119e-06 1.52106725535721 0.846153846153846 18.2 18 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000428828916423056 0.00139320444764842 1.52106725535721 0.846153846153846 18.2 18 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.07980417724385e-08 1.54143820011354e-07 1.51674604156358 0.84375 18.2 18 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 5.5123528036483e-11 7.54238273037647e-10 1.51163915253475 0.840909090909091 18.2 18 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 2.32161810643795e-06 1.11234429813509e-05 1.49802078179119 0.833333333333333 18.2 18 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 2.32161810643795e-06 1.11234429813509e-05 1.49802078179119 0.833333333333333 18.2 18 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 4.75891396021967e-05 0.000182531928986323 1.49802078179119 0.833333333333333 18.2 18 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 4.75891396021967e-05 0.000182531928986323 1.49802078179119 0.833333333333333 18.2 18 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 4.75891396021967e-05 0.000182531928986323 1.49802078179119 0.833333333333333 18.2 18 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0010240860543666 0.00301089763504892 1.49802078179119 0.833333333333333 18.2 18 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0010240860543666 0.00301089763504892 1.49802078179119 0.833333333333333 18.2 18 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0010240860543666 0.00301089763504892 1.49802078179119 0.833333333333333 18.2 18 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0010240860543666 0.00301089763504892 1.49802078179119 0.833333333333333 18.2 18 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0010240860543666 0.00301089763504892 1.49802078179119 0.833333333333333 18.2 18 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0010240860543666 0.00301089763504892 1.49802078179119 0.833333333333333 18.2 18 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0010240860543666 0.00301089763504892 1.49802078179119 0.833333333333333 18.2 18 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0245719100529037 0.0493867627193248 1.49802078179119 0.833333333333333 18.2 18 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 7.18364320966154e-10 7.19881992066787e-09 1.49071336334343 0.829268292682927 18.2 18 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 7.18364320966154e-10 7.19881992066787e-09 1.49071336334343 0.829268292682927 18.2 18 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 5.44729166343448e-06 2.40729690592151e-05 1.48499451412344 0.826086956521739 18.2 18 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 5.44729166343448e-06 2.40729690592151e-05 1.48499451412344 0.826086956521739 18.2 18 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.000111809615921455 0.00041006464808307 1.48039700788777 0.823529411764706 18.2 18 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000111809615921455 0.00041006464808307 1.48039700788777 0.823529411764706 18.2 18 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000111809615921455 0.00041006464808307 1.48039700788777 0.823529411764706 18.2 18 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.02644578998539e-10 2.36363308126984e-09 1.47804717136731 0.822222222222222 18.2 18 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.02644578998539e-10 2.36363308126984e-09 1.47804717136731 0.822222222222222 18.2 18 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 6.35655754979197e-07 3.41335146919018e-06 1.47662048490846 0.821428571428571 18.2 18 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 1.26768119441652e-05 5.25921381823532e-05 1.47078404030408 0.818181818181818 18.2 18 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 1.26768119441652e-05 5.25921381823532e-05 1.47078404030408 0.818181818181818 18.2 18 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00241238074102869 0.00648925859070667 1.47078404030408 0.818181818181818 18.2 18 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00241238074102869 0.00648925859070667 1.47078404030408 0.818181818181818 18.2 18 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00241238074102869 0.00648925859070667 1.47078404030408 0.818181818181818 18.2 18 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00241238074102869 0.00648925859070667 1.47078404030408 0.818181818181818 18.2 18 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00241238074102869 0.00648925859070667 1.47078404030408 0.818181818181818 18.2 18 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 5.67558963244545e-11 7.69177528282845e-10 1.46744892910158 0.816326530612245 18.2 18 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 1.47008036869454e-06 7.31442085542772e-06 1.46473143108472 0.814814814814815 18.2 18 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000259853436939223 0.000897288238263956 1.46057026224641 0.8125 18.2 18 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000259853436939223 0.000897288238263956 1.46057026224641 0.8125 18.2 18 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000259853436939223 0.000897288238263956 1.46057026224641 0.8125 18.2 18 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000259853436939223 0.000897288238263956 1.46057026224641 0.8125 18.2 18 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000259853436939223 0.000897288238263956 1.46057026224641 0.8125 18.2 18 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 2.92374225269476e-05 0.000116214671105716 1.45522018802573 0.80952380952381 18.2 18 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 3.37397317357894e-06 1.58978934635855e-05 1.45192783465916 0.807692307692308 18.2 18 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 4.69719992214338e-08 3.30896806396536e-07 1.44808675573149 0.805555555555556 18.2 18 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 1.06509975600048e-07 7.01683774439205e-07 1.43809995051954 0.8 18.2 18 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 1.06509975600048e-07 7.01683774439205e-07 1.43809995051954 0.8 18.2 18 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.06509975600048e-07 7.01683774439205e-07 1.43809995051954 0.8 18.2 18 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 7.6798524079681e-06 3.29169577606585e-05 1.43809995051954 0.8 18.2 18 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 7.6798524079681e-06 3.29169577606585e-05 1.43809995051954 0.8 18.2 18 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.000596541919686023 0.00187805122060445 1.43809995051954 0.8 18.2 18 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000596541919686023 0.00187805122060445 1.43809995051954 0.8 18.2 18 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000596541919686023 0.00187805122060445 1.43809995051954 0.8 18.2 18 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000596541919686023 0.00187805122060445 1.43809995051954 0.8 18.2 18 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000596541919686023 0.00187805122060445 1.43809995051954 0.8 18.2 18 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00559120667524334 0.0137652025932029 1.43809995051954 0.8 18.2 18 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00559120667524334 0.0137652025932029 1.43809995051954 0.8 18.2 18 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00559120667524334 0.0137652025932029 1.43809995051954 0.8 18.2 18 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00559120667524334 0.0137652025932029 1.43809995051954 0.8 18.2 18 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 9.23234191676195e-14 1.85036937289468e-12 1.43288944345245 0.797101449275362 18.2 18 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 1.73248511800212e-05 7.06397227196854e-05 1.42311974270163 0.791666666666667 18.2 18 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 1.73248511800212e-05 7.06397227196854e-05 1.42311974270163 0.791666666666667 18.2 18 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 1.73248511800212e-05 7.06397227196854e-05 1.42311974270163 0.791666666666667 18.2 18 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 4.52963728565078e-06 2.05932072123996e-05 1.41241959426027 0.785714285714286 18.2 18 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0013504350941944 0.00385104035879485 1.41241959426027 0.785714285714286 18.2 18 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0013504350941944 0.00385104035879485 1.41241959426027 0.785714285714286 18.2 18 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0013504350941944 0.00385104035879485 1.41241959426027 0.785714285714286 18.2 18 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0013504350941944 0.00385104035879485 1.41241959426027 0.785714285714286 18.2 18 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0013504350941944 0.00385104035879485 1.41241959426027 0.785714285714286 18.2 18 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0013504350941944 0.00385104035879485 1.41241959426027 0.785714285714286 18.2 18 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.4261963177656e-07 9.10079533713203e-07 1.40894927584685 0.783783783783784 18.2 18 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.4261963177656e-07 9.10079533713203e-07 1.40894927584685 0.783783783783784 18.2 18 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 1.00375979906743e-05 4.26373192260585e-05 1.39815272967178 0.777777777777778 18.2 18 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000336581283038861 0.00112430790085516 1.39815272967178 0.777777777777778 18.2 18 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0127077478243781 0.0282108036725274 1.39815272967178 0.777777777777778 18.2 18 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0127077478243781 0.0282108036725274 1.39815272967178 0.777777777777778 18.2 18 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0127077478243781 0.0282108036725274 1.39815272967178 0.777777777777778 18.2 18 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0127077478243781 0.0282108036725274 1.39815272967178 0.777777777777778 18.2 18 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0127077478243781 0.0282108036725274 1.39815272967178 0.777777777777778 18.2 18 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0127077478243781 0.0282108036725274 1.39815272967178 0.777777777777778 18.2 18 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0127077478243781 0.0282108036725274 1.39815272967178 0.777777777777778 18.2 18 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0127077478243781 0.0282108036725274 1.39815272967178 0.777777777777778 18.2 18 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 8.97718229840267e-11 1.13048941686965e-09 1.39470900373663 0.775862068965517 18.2 18 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 8.97718229840267e-11 1.13048941686965e-09 1.39470900373663 0.775862068965517 18.2 18 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 8.35548971475931e-08 5.74389462033937e-07 1.39315932706581 0.775 18.2 18 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 8.55434985084078e-05 0.000319497108602268 1.38907381584274 0.772727272727273 18.2 18 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 8.55434985084078e-05 0.000319497108602268 1.38907381584274 0.772727272727273 18.2 18 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 5.93756574554877e-09 4.87984136415592e-08 1.38566922315685 0.770833333333333 18.2 18 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.20327831892654e-05 8.85668092608041e-05 1.3827884139611 0.769230769230769 18.2 18 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 2.20327831892654e-05 8.85668092608041e-05 1.3827884139611 0.769230769230769 18.2 18 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00300827651417842 0.00795683546408158 1.3827884139611 0.769230769230769 18.2 18 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00300827651417842 0.00795683546408158 1.3827884139611 0.769230769230769 18.2 18 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00300827651417842 0.00795683546408158 1.3827884139611 0.769230769230769 18.2 18 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.50103248258336e-06 7.41655980109764e-06 1.37465436446721 0.764705882352941 18.2 18 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.50103248258336e-06 7.41655980109764e-06 1.37465436446721 0.764705882352941 18.2 18 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000740995855246964 0.00228390003598969 1.37465436446721 0.764705882352941 18.2 18 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000740995855246964 0.00228390003598969 1.37465436446721 0.764705882352941 18.2 18 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.44053837250769e-09 3.19992555822121e-08 1.37465436446721 0.764705882352941 18.2 18 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.44053837250769e-09 3.19992555822121e-08 1.37465436446721 0.764705882352941 18.2 18 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 3.44053837250769e-09 3.19992555822121e-08 1.37465436446721 0.764705882352941 18.2 18 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 6.62752657839257e-11 8.49636965860597e-10 1.3696190004948 0.761904761904762 18.2 18 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000186871187514514 0.000663136408561481 1.3696190004948 0.761904761904762 18.2 18 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.97929706361027e-09 1.91601341599824e-08 1.36486337896531 0.759259259259259 18.2 18 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 1.23976883045687e-05 5.1887971933533e-05 1.36371547032026 0.758620689655172 18.2 18 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.23976883045687e-05 5.1887971933533e-05 1.36371547032026 0.758620689655172 18.2 18 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 1.23976883045687e-05 5.1887971933533e-05 1.36371547032026 0.758620689655172 18.2 18 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.4213951018355e-10 1.75882193905384e-09 1.36271567891973 0.758064516129032 18.2 18 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.15673436957516e-13 2.22436892960196e-12 1.3535058357831 0.752941176470588 18.2 18 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.15673436957516e-13 2.22436892960196e-12 1.3535058357831 0.752941176470588 18.2 18 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.15673436957516e-13 2.22436892960196e-12 1.3535058357831 0.752941176470588 18.2 18 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 8.44932242296185e-15 2.73258768360789e-13 1.35305102871463 0.752688172043011 18.2 18 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 2.65614801057451e-05 0.000106171309523807 1.34821870361207 0.75 18.2 18 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.26908531497787e-07 8.24615709229912e-07 1.34821870361207 0.75 18.2 18 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.26908531497787e-07 8.24615709229912e-07 1.34821870361207 0.75 18.2 18 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 4.7904322681659e-07 2.78236127248983e-06 1.34821870361207 0.75 18.2 18 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000402987202652209 0.00131827767672205 1.34821870361207 0.75 18.2 18 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000402987202652209 0.00131827767672205 1.34821870361207 0.75 18.2 18 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000402987202652209 0.00131827767672205 1.34821870361207 0.75 18.2 18 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000402987202652209 0.00131827767672205 1.34821870361207 0.75 18.2 18 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000402987202652209 0.00131827767672205 1.34821870361207 0.75 18.2 18 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00160660736792642 0.00451818633312114 1.34821870361207 0.75 18.2 18 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00160660736792642 0.00451818633312114 1.34821870361207 0.75 18.2 18 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00160660736792642 0.00451818633312114 1.34821870361207 0.75 18.2 18 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00160660736792642 0.00451818633312114 1.34821870361207 0.75 18.2 18 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00657726480101497 0.0157037714963831 1.34821870361207 0.75 18.2 18 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00657726480101497 0.0157037714963831 1.34821870361207 0.75 18.2 18 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00657726480101497 0.0157037714963831 1.34821870361207 0.75 18.2 18 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00657726480101497 0.0157037714963831 1.34821870361207 0.75 18.2 18 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0281964024953567 0.0549636722614967 1.34821870361207 0.75 18.2 18 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0281964024953567 0.0549636722614967 1.34821870361207 0.75 18.2 18 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0281964024953567 0.0549636722614967 1.34821870361207 0.75 18.2 18 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0281964024953567 0.0549636722614967 1.34821870361207 0.75 18.2 18 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0281964024953567 0.0549636722614967 1.34821870361207 0.75 18.2 18 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0281964024953567 0.0549636722614967 1.34821870361207 0.75 18.2 18 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0281964024953567 0.0549636722614967 1.34821870361207 0.75 18.2 18 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0281964024953567 0.0549636722614967 1.34821870361207 0.75 18.2 18 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 6.44101263374335e-10 6.59392876101928e-09 1.34821870361207 0.75 18.2 18 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 6.44101263374335e-10 6.59392876101928e-09 1.34821870361207 0.75 18.2 18 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 6.44101263374335e-10 6.59392876101928e-09 1.34821870361207 0.75 18.2 18 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 6.44101263374335e-10 6.59392876101928e-09 1.34821870361207 0.75 18.2 18 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 6.44101263374335e-10 6.59392876101928e-09 1.34821870361207 0.75 18.2 18 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 6.44101263374335e-10 6.59392876101928e-09 1.34821870361207 0.75 18.2 18 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 6.44101263374335e-10 6.59392876101928e-09 1.34821870361207 0.75 18.2 18 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 7.93011427401595e-31 1.25383917910274e-28 1.34393864423553 0.747619047619048 18.2 18 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 7.10962606686561e-12 1.09967368403802e-10 1.34222662048491 0.746666666666667 18.2 18 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 7.10962606686561e-12 1.09967368403802e-10 1.34222662048491 0.746666666666667 18.2 18 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 7.10962606686561e-12 1.09967368403802e-10 1.34222662048491 0.746666666666667 18.2 18 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 7.10962606686561e-12 1.09967368403802e-10 1.34222662048491 0.746666666666667 18.2 18 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 7.10962606686561e-12 1.09967368403802e-10 1.34222662048491 0.746666666666667 18.2 18 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 9.80786212094085e-11 1.22426208755253e-09 1.34151114787271 0.746268656716418 18.2 18 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.90088167758951e-08 1.41620661110465e-07 1.33940681666036 0.745098039215686 18.2 18 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 6.15871811293424e-13 1.13816310061109e-11 1.33235730709899 0.741176470588235 18.2 18 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 5.63047408995255e-05 0.000213089484840492 1.33157402825884 0.740740740740741 18.2 18 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 5.63047408995255e-05 0.000213089484840492 1.33157402825884 0.740740740740741 18.2 18 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 5.63047408995255e-05 0.000213089484840492 1.33157402825884 0.740740740740741 18.2 18 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 5.63047408995255e-05 0.000213089484840492 1.33157402825884 0.740740740740741 18.2 18 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 5.74870186282781e-18 3.02977879659406e-16 1.32995015749267 0.739837398373984 18.2 18 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.49695169344687e-07 9.38397471266472e-07 1.32867930211045 0.739130434782609 18.2 18 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000218258003576973 0.000770672801712239 1.32867930211045 0.739130434782609 18.2 18 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.14116734434777e-22 1.0149257068793e-20 1.32574839188521 0.7375 18.2 18 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000856702363890754 0.00259380311450328 1.32456574389958 0.736842105263158 18.2 18 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000856702363890754 0.00259380311450328 1.32456574389958 0.736842105263158 18.2 18 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000856702363890754 0.00259380311450328 1.32456574389958 0.736842105263158 18.2 18 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.67043477482186e-12 4.75003585571438e-11 1.32114603888091 0.734939759036145 18.2 18 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 8.32528403842244e-08 5.74389462033937e-07 1.32070403619142 0.73469387755102 18.2 18 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 9.86833230060877e-12 1.44769452203776e-10 1.31977527104642 0.734177215189873 18.2 18 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 9.86833230060877e-12 1.44769452203776e-10 1.31977527104642 0.734177215189873 18.2 18 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00342364132409243 0.00892278682084894 1.31825828797625 0.733333333333333 18.2 18 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00342364132409243 0.00892278682084894 1.31825828797625 0.733333333333333 18.2 18 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00342364132409243 0.00892278682084894 1.31825828797625 0.733333333333333 18.2 18 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00342364132409243 0.00892278682084894 1.31825828797625 0.733333333333333 18.2 18 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.23919450761577e-08 9.58355317574586e-08 1.31611825828798 0.732142857142857 18.2 18 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.17260466049095e-06 5.91707954566888e-06 1.31533532059714 0.731707317073171 18.2 18 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.17260466049095e-06 5.91707954566888e-06 1.31533532059714 0.731707317073171 18.2 18 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.17260466049095e-06 5.91707954566888e-06 1.31533532059714 0.731707317073171 18.2 18 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.17260466049095e-06 5.91707954566888e-06 1.31533532059714 0.731707317073171 18.2 18 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.17260466049095e-06 5.91707954566888e-06 1.31533532059714 0.731707317073171 18.2 18 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.17260466049095e-06 5.91707954566888e-06 1.31533532059714 0.731707317073171 18.2 18 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000117989735569079 0.000428314779884691 1.31364899326305 0.730769230769231 18.2 18 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000117989735569079 0.000428314779884691 1.31364899326305 0.730769230769231 18.2 18 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000117989735569079 0.000428314779884691 1.31364899326305 0.730769230769231 18.2 18 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4.42212626810232e-06 2.01688643574026e-05 1.31178036027121 0.72972972972973 18.2 18 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.27325734478447e-15 1.7866298099115e-13 1.31041817921173 0.728971962616822 18.2 18 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 7.11709298542114e-14 1.80850416397398e-12 1.3073635913814 0.727272727272727 18.2 18 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.67461091033096e-05 6.88720036243051e-05 1.3073635913814 0.727272727272727 18.2 18 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0140680758331491 0.0304238174932692 1.3073635913814 0.727272727272727 18.2 18 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.54889664128642e-10 1.88382899192357e-09 1.30512495509479 0.726027397260274 18.2 18 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.33559099147055e-11 3.32354598086259e-10 1.30327808015834 0.725 18.2 18 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 6.03994369613914e-15 1.9987999720014e-13 1.3028657808606 0.724770642201835 18.2 18 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 9.11476347303312e-06 3.88332587488806e-05 1.29828467755237 0.722222222222222 18.2 18 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00179247374298802 0.00497210552879524 1.29828467755237 0.722222222222222 18.2 18 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00179247374298802 0.00497210552879524 1.29828467755237 0.722222222222222 18.2 18 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 4.51232215102229e-14 1.23481431171245e-12 1.29636413808853 0.721153846153846 18.2 18 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 7.20011794746329e-12 1.10169546658497e-10 1.29596216471238 0.720930232558139 18.2 18 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 1.32467913367728e-06 6.63738875782667e-06 1.29596216471238 0.720930232558139 18.2 18 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.99122381823748e-12 6.68177822747286e-11 1.29267411282656 0.719101123595506 18.2 18 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 4.95816146979655e-06 2.21869929922028e-05 1.29060251969703 0.717948717948718 18.2 18 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 7.24009356280343e-07 3.84427355965271e-06 1.2896004991072 0.717391304347826 18.2 18 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 7.24009356280343e-07 3.84427355965271e-06 1.2896004991072 0.717391304347826 18.2 18 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 7.24009356280343e-07 3.84427355965271e-06 1.2896004991072 0.717391304347826 18.2 18 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.64640073944247e-20 1.79325154867935e-18 1.28886316320148 0.716981132075472 18.2 18 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000130662892883976 0.000473112713928495 1.28401781296388 0.714285714285714 18.2 18 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00094327724049644 0.00283182175786168 1.28401781296388 0.714285714285714 18.2 18 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00094327724049644 0.00283182175786168 1.28401781296388 0.714285714285714 18.2 18 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00715288006413847 0.0168240468285439 1.28401781296388 0.714285714285714 18.2 18 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00715288006413847 0.0168240468285439 1.28401781296388 0.714285714285714 18.2 18 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00715288006413847 0.0168240468285439 1.28401781296388 0.714285714285714 18.2 18 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0607007263024421 0.10369403784919 1.28401781296388 0.714285714285714 18.2 18 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.07723880214013e-19 6.96777643384273e-18 1.2823821214824 0.713375796178344 18.2 18 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.68299453275323e-17 8.25828006933742e-16 1.28032279767477 0.712230215827338 18.2 18 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 5.03828643093998e-21 3.77341136380399e-19 1.27948598538871 0.711764705882353 18.2 18 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.62605684892199e-09 2.49125259734399e-08 1.27657423143945 0.710144927536232 18.2 18 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.0105783011972e-20 7.19026461301804e-19 1.27642007442563 0.710059171597633 18.2 18 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.24947366812629e-32 4.57285861391958e-30 1.27552063626044 0.709558823529412 18.2 18 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.1680367942779e-10 2.44850504623607e-09 1.27426577894137 0.708860759493671 18.2 18 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000498564245586042 0.00160510615716954 1.27331766452251 0.708333333333333 18.2 18 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 4.43022287316279e-16 1.80120204243161e-14 1.27216534084421 0.707692307692308 18.2 18 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 6.53908436609337e-11 8.45919732086443e-10 1.26891172104666 0.705882352941177 18.2 18 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 6.53908436609337e-11 8.45919732086443e-10 1.26891172104666 0.705882352941177 18.2 18 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 6.53908436609337e-11 8.45919732086443e-10 1.26891172104666 0.705882352941177 18.2 18 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 6.53908436609337e-11 8.45919732086443e-10 1.26891172104666 0.705882352941177 18.2 18 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 6.53908436609337e-11 8.45919732086443e-10 1.26891172104666 0.705882352941177 18.2 18 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00368407499835711 0.00946288578097864 1.26891172104666 0.705882352941177 18.2 18 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00368407499835711 0.00946288578097864 1.26891172104666 0.705882352941177 18.2 18 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00368407499835711 0.00946288578097864 1.26891172104666 0.705882352941177 18.2 18 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00368407499835711 0.00946288578097864 1.26891172104666 0.705882352941177 18.2 18 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00368407499835711 0.00946288578097864 1.26891172104666 0.705882352941177 18.2 18 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00368407499835711 0.00946288578097864 1.26891172104666 0.705882352941177 18.2 18 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.4577261531253e-19 9.01888832998829e-18 1.26826299317291 0.705521472392638 18.2 18 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.37344252226508e-10 2.59800669937169e-09 1.2649953268459 0.703703703703704 18.2 18 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.37344252226508e-10 2.59800669937169e-09 1.2649953268459 0.703703703703704 18.2 18 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.37344252226508e-10 2.59800669937169e-09 1.2649953268459 0.703703703703704 18.2 18 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000264491597909267 0.000897288238263956 1.2649953268459 0.703703703703704 18.2 18 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000264491597909267 0.000897288238263956 1.2649953268459 0.703703703703704 18.2 18 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000264491597909267 0.000897288238263956 1.2649953268459 0.703703703703704 18.2 18 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000264491597909267 0.000897288238263956 1.2649953268459 0.703703703703704 18.2 18 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000264491597909267 0.000897288238263956 1.2649953268459 0.703703703703704 18.2 18 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.15012685881223e-14 3.48219259593575e-13 1.26279437803886 0.702479338842975 18.2 18 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.15012685881223e-14 3.48219259593575e-13 1.26279437803886 0.702479338842975 18.2 18 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.54214580030515e-14 1.85036937289468e-12 1.26149118466627 0.701754385964912 18.2 18 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.60517998912089e-16 7.36829395006136e-15 1.2583374567046 0.7 18.2 18 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.90317462218063e-11 5.49922523501291e-10 1.2583374567046 0.7 18.2 18 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00191537107344736 0.00528747563582998 1.2583374567046 0.7 18.2 18 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0293130105056926 0.0562161913067394 1.2583374567046 0.7 18.2 18 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0293130105056926 0.0562161913067394 1.2583374567046 0.7 18.2 18 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0293130105056926 0.0562161913067394 1.2583374567046 0.7 18.2 18 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0293130105056926 0.0562161913067394 1.2583374567046 0.7 18.2 18 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0293130105056926 0.0562161913067394 1.2583374567046 0.7 18.2 18 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000140758313826211 0.000505805759027016 1.2583374567046 0.7 18.2 18 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.43185478308947e-21 3.50362742018684e-19 1.25735514799523 0.699453551912568 18.2 18 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.80090974229869e-08 2.73166392085406e-07 1.2554840837869 0.698412698412698 18.2 18 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.80090974229869e-08 2.73166392085406e-07 1.2554840837869 0.698412698412698 18.2 18 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.16554255770522e-16 1.32487266459251e-14 1.25445769065104 0.697841726618705 18.2 18 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.46265716493422e-17 7.43343266321926e-16 1.2536068647621 0.697368421052632 18.2 18 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 7.51126493719222e-05 0.000282765344064141 1.25289010840718 0.696969696969697 18.2 18 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 7.51126493719222e-05 0.000282765344064141 1.25289010840718 0.696969696969697 18.2 18 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.12692912927704e-08 8.81109973055623e-08 1.25052169610395 0.695652173913043 18.2 18 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 3.1625109778576e-06 1.50008437383045e-05 1.25052169610395 0.695652173913043 18.2 18 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00100295345447288 0.00300463740150506 1.25052169610395 0.695652173913043 18.2 18 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.37911197577911e-07 8.8799834458537e-07 1.2491969909174 0.694915254237288 18.2 18 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.37911197577911e-07 8.8799834458537e-07 1.2491969909174 0.694915254237288 18.2 18 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.1383809148553e-09 4.87984136415592e-08 1.24835065149266 0.694444444444444 18.2 18 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 4.01762559839311e-05 0.000157495350592655 1.24835065149266 0.694444444444444 18.2 18 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.76795544484201e-10 3.00671801374823e-09 1.24776319236255 0.694117647058824 18.2 18 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 4.74544064613289e-18 2.70110481577884e-16 1.24710230084117 0.69375 18.2 18 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.51138249436784e-10 1.85404938748744e-09 1.2460809230354 0.693181818181818 18.2 18 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.45016910459449e-14 4.29914715799574e-13 1.24559838233976 0.692913385826772 18.2 18 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 6.68543021241875e-16 2.6426019978533e-14 1.24549727857496 0.692857142857143 18.2 18 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 9.2330212143806e-07 4.81267003225773e-06 1.24450957256499 0.692307692307692 18.2 18 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000528141711915933 0.00168886664282331 1.24450957256499 0.692307692307692 18.2 18 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.000528141711915933 0.00168886664282331 1.24450957256499 0.692307692307692 18.2 18 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0146074884463972 0.0309404193235715 1.24450957256499 0.692307692307692 18.2 18 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0146074884463972 0.0309404193235715 1.24450957256499 0.692307692307692 18.2 18 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.82246122580086e-09 1.77627556459906e-08 1.24450957256499 0.692307692307692 18.2 18 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.35104226773101e-15 1.51013003584908e-13 1.24346988202818 0.691729323308271 18.2 18 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.15619327560857e-05 4.88208614596736e-05 1.24121721919842 0.69047619047619 18.2 18 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.15619327560857e-05 4.88208614596736e-05 1.24121721919842 0.69047619047619 18.2 18 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.46554419369664e-07 9.22774065323151e-07 1.2377089738078 0.688524590163934 18.2 18 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.46554419369664e-07 9.22774065323151e-07 1.2377089738078 0.688524590163934 18.2 18 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.46554419369664e-07 9.22774065323151e-07 1.2377089738078 0.688524590163934 18.2 18 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 7.94602403224536e-08 5.51570351116349e-07 1.23586714497773 0.6875 18.2 18 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 3.34846152391125e-06 1.58301021545704e-05 1.23586714497773 0.6875 18.2 18 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00742111602765766 0.0171711351339136 1.23586714497773 0.6875 18.2 18 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00742111602765766 0.0171711351339136 1.23586714497773 0.6875 18.2 18 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00742111602765766 0.0171711351339136 1.23586714497773 0.6875 18.2 18 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00742111602765766 0.0171711351339136 1.23586714497773 0.6875 18.2 18 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00742111602765766 0.0171711351339136 1.23586714497773 0.6875 18.2 18 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 4.31081833659098e-08 3.05188780744725e-07 1.23419025604289 0.686567164179104 18.2 18 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 4.31081833659098e-08 3.05188780744725e-07 1.23419025604289 0.686567164179104 18.2 18 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 7.90091817477474e-05 0.000296649249675579 1.23265710044532 0.685714285714286 18.2 18 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.83431242152328e-14 1.56645784449578e-12 1.23144385526772 0.68503937007874 18.2 18 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.27079144004739e-08 9.77479037398615e-08 1.2312499576366 0.684931506849315 18.2 18 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.70366052141558e-10 2.05449908641896e-09 1.23098229460233 0.684782608695652 18.2 18 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 6.90466782607943e-09 5.4585235091728e-08 1.22995390504961 0.684210526315789 18.2 18 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0038199783976988 0.00972396057113647 1.22995390504961 0.684210526315789 18.2 18 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.84824382203968e-07 1.73950684925427e-06 1.22837704106878 0.683333333333333 18.2 18 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 2.04090940438005e-09 1.9623068124546e-08 1.227646299224 0.682926829268293 18.2 18 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00198513198827996 0.00544285706998532 1.22565336692007 0.681818181818182 18.2 18 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 7.27114273173978e-13 1.32651744964945e-11 1.22359344529499 0.680672268907563 18.2 18 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 5.31286223306279e-11 7.34000287150325e-10 1.22238495794161 0.68 18.2 18 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0010391087871453 0.00303002418874542 1.22238495794161 0.68 18.2 18 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0010391087871453 0.00303002418874542 1.22238495794161 0.68 18.2 18 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0010391087871453 0.00303002418874542 1.22238495794161 0.68 18.2 18 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0010391087871453 0.00303002418874542 1.22238495794161 0.68 18.2 18 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 3.93037135964176e-09 3.63176522387677e-08 1.22060952590393 0.679012345679012 18.2 18 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 8.60103615332191e-12 1.28834467854496e-10 1.22040592131246 0.678899082568807 18.2 18 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00054701886407377 0.00174140457176057 1.21981692231569 0.678571428571429 18.2 18 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 9.56530874162476e-42 2.72228686786641e-39 1.21951550968353 0.678403755868545 18.2 18 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 5.49562281258327e-07 3.00779663934846e-06 1.21872877162673 0.677966101694915 18.2 18 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 5.49562281258327e-07 3.00779663934846e-06 1.21872877162673 0.677966101694915 18.2 18 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000289290868579369 0.000970898363180288 1.21774592584316 0.67741935483871 18.2 18 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 4.36667987673834e-05 0.00016977555914204 1.21339683325087 0.675 18.2 18 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 4.36667987673834e-05 0.00016977555914204 1.21339683325087 0.675 18.2 18 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.35738770738343e-13 4.4138982994824e-12 1.21235170247287 0.674418604651163 18.2 18 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.71135333361347e-25 1.87327368748613e-23 1.21219152917356 0.674329501915709 18.2 18 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.25319485877904e-05 5.2296078710926e-05 1.2114428931007 0.673913043478261 18.2 18 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.94284427927601e-10 2.31932263573521e-09 1.2106453665088 0.673469387755102 18.2 18 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.01251203366696e-15 3.89406655110295e-14 1.20993986221596 0.673076923076923 18.2 18 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.70798146846924e-11 2.45500770669872e-10 1.2093113220278 0.672727272727273 18.2 18 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.70798146846924e-11 2.45500770669872e-10 1.2093113220278 0.672727272727273 18.2 18 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.95118027724925e-06 9.50866278947151e-06 1.2093113220278 0.672727272727273 18.2 18 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.95118027724925e-06 9.50866278947151e-06 1.2093113220278 0.672727272727273 18.2 18 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 8.83522694279868e-22 7.39560467035443e-20 1.20916475660276 0.672645739910314 18.2 18 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.0524333558812e-06 5.46573965481367e-06 1.20874780323841 0.672413793103448 18.2 18 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.15344922360863e-28 4.92529853766257e-26 1.20864202326088 0.672354948805461 18.2 18 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 3.07148378967197e-07 1.84418625852456e-06 1.20777925531915 0.671875 18.2 18 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.66155998512971e-07 1.0279999386259e-06 1.20736003308544 0.671641791044776 18.2 18 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.04846688301912e-15 3.92623256456896e-14 1.2060015407838 0.670886075949367 18.2 18 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 4.22439401524664e-09 3.85340556647178e-08 1.20546613499432 0.670588235294118 18.2 18 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 4.22439401524664e-09 3.85340556647178e-08 1.20546613499432 0.670588235294118 18.2 18 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 5.39887851626217e-17 2.56086804288036e-15 1.19841662543295 0.666666666666667 18.2 18 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.93602658130664e-12 5.09508027463335e-11 1.19841662543295 0.666666666666667 18.2 18 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 5.00357019322396e-08 3.50742876106291e-07 1.19841662543295 0.666666666666667 18.2 18 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 9.23338442075158e-08 6.28665360321986e-07 1.19841662543295 0.666666666666667 18.2 18 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 9.23338442075158e-08 6.28665360321986e-07 1.19841662543295 0.666666666666667 18.2 18 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.70507976820722e-07 1.05035866240644e-06 1.19841662543295 0.666666666666667 18.2 18 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 3.71044061105498e-06 1.74256006255156e-05 1.19841662543295 0.666666666666667 18.2 18 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 4.46310671424224e-05 0.000172581544955617 1.19841662543295 0.666666666666667 18.2 18 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00015667503327538 0.000560172292338859 1.19841662543295 0.666666666666667 18.2 18 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00015667503327538 0.000560172292338859 1.19841662543295 0.666666666666667 18.2 18 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00105544193992926 0.00305290748774828 1.19841662543295 0.666666666666667 18.2 18 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00105544193992926 0.00305290748774828 1.19841662543295 0.666666666666667 18.2 18 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00105544193992926 0.00305290748774828 1.19841662543295 0.666666666666667 18.2 18 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0038595587393492 0.00977251260870802 1.19841662543295 0.666666666666667 18.2 18 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0038595587393492 0.00977251260870802 1.19841662543295 0.666666666666667 18.2 18 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00746727750909529 0.0172498959341601 1.19841662543295 0.666666666666667 18.2 18 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0290496978974173 0.0560891724667908 1.19841662543295 0.666666666666667 18.2 18 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0290496978974173 0.0560891724667908 1.19841662543295 0.666666666666667 18.2 18 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0290496978974173 0.0560891724667908 1.19841662543295 0.666666666666667 18.2 18 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0290496978974173 0.0560891724667908 1.19841662543295 0.666666666666667 18.2 18 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0290496978974173 0.0560891724667908 1.19841662543295 0.666666666666667 18.2 18 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0290496978974173 0.0560891724667908 1.19841662543295 0.666666666666667 18.2 18 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0591737118373139 0.10231372046719 1.19841662543295 0.666666666666667 18.2 18 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0146113575442305 0.0309404193235715 1.19841662543295 0.666666666666667 18.2 18 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0146113575442305 0.0309404193235715 1.19841662543295 0.666666666666667 18.2 18 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0146113575442305 0.0309404193235715 1.19841662543295 0.666666666666667 18.2 18 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0146113575442305 0.0309404193235715 1.19841662543295 0.666666666666667 18.2 18 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 8.16225817673244e-09 6.41706816877915e-08 1.191449086913 0.662790697674419 18.2 18 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.50093967779375e-19 1.48284881729188e-17 1.18985650667986 0.661904761904762 18.2 18 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 3.2099780120859e-07 1.91924315596565e-06 1.18960473848124 0.661764705882353 18.2 18 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.19174979801591e-46 1.13546499064416e-43 1.18930319101902 0.661596958174905 18.2 18 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.59239061296038e-23 1.61855131588759e-21 1.18919803600655 0.661538461538462 18.2 18 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 3.76905154745928e-06 1.75783691588652e-05 1.18771647699159 0.660714285714286 18.2 18 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 6.99586765078148e-06 3.03736158183881e-05 1.18711080821189 0.660377358490566 18.2 18 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 6.99586765078148e-06 3.03736158183881e-05 1.18711080821189 0.660377358490566 18.2 18 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 2.4204214223255e-05 9.70213995484279e-05 1.18566751239643 0.659574468085106 18.2 18 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 5.17810454944198e-08 3.61198175189017e-07 1.18324679473127 0.658227848101266 18.2 18 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 9.54470518021189e-08 6.43767967182871e-07 1.18264798562463 0.657894736842105 18.2 18 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.76041058332275e-07 1.07976907761563e-06 1.18199995933113 0.657534246575342 18.2 18 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 6.0006420194498e-07 3.24673520672132e-06 1.18052981012798 0.656716417910448 18.2 18 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.54245169628103e-08 1.16750466159995e-07 1.17775426982204 0.655172413793103 18.2 18 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.54245169628103e-08 1.16750466159995e-07 1.17775426982204 0.655172413793103 18.2 18 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 3.79969940780849e-06 1.75783691588652e-05 1.17775426982204 0.655172413793103 18.2 18 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.00105553793673377 0.00305290748774828 1.17775426982204 0.655172413793103 18.2 18 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.83814664746534e-08 2.07111932274009e-07 1.17701632855022 0.654761904761905 18.2 18 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.83814664746534e-08 2.07111932274009e-07 1.17701632855022 0.654761904761905 18.2 18 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 7.04377598037109e-06 3.03736158183881e-05 1.17662723224326 0.654545454545455 18.2 18 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 7.04377598037109e-06 3.03736158183881e-05 1.17662723224326 0.654545454545455 18.2 18 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 7.04377598037109e-06 3.03736158183881e-05 1.17662723224326 0.654545454545455 18.2 18 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 7.04377598037109e-06 3.03736158183881e-05 1.17662723224326 0.654545454545455 18.2 18 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 7.04377598037109e-06 3.03736158183881e-05 1.17662723224326 0.654545454545455 18.2 18 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 4.04446818606662e-10 4.36005926422182e-09 1.1760163146772 0.654205607476635 18.2 18 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00200426881813411 0.00547423134012446 1.17537015186694 0.653846153846154 18.2 18 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00200426881813411 0.00547423134012446 1.17537015186694 0.653846153846154 18.2 18 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.26927487104393e-07 1.92404192053856e-06 1.1734496124031 0.652777777777778 18.2 18 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.00382671673916825 0.00972396057113647 1.17236409009745 0.652173913043478 18.2 18 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.21916777842642e-10 2.48651633755969e-09 1.17166625432954 0.651785714285714 18.2 18 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.51170256809949e-09 2.39876023785609e-08 1.16845620979713 0.65 18.2 18 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.80473485659204e-06 1.75783691588652e-05 1.16845620979713 0.65 18.2 18 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00735710628559431 0.0171625610563946 1.16845620979713 0.65 18.2 18 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00735710628559431 0.0171625610563946 1.16845620979713 0.65 18.2 18 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00735710628559431 0.0171625610563946 1.16845620979713 0.65 18.2 18 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00735710628559431 0.0171625610563946 1.16845620979713 0.65 18.2 18 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00735710628559431 0.0171625610563946 1.16845620979713 0.65 18.2 18 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 3.27208815720543e-07 1.92404192053856e-06 1.16602698690774 0.648648648648649 18.2 18 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 3.27208815720543e-07 1.92404192053856e-06 1.16602698690774 0.648648648648649 18.2 18 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 6.02942648964342e-07 3.24995223286462e-06 1.16465841063203 0.647887323943662 18.2 18 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0142723579147087 0.0305406997182413 1.1631690776261 0.647058823529412 18.2 18 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0142723579147087 0.0305406997182413 1.1631690776261 0.647058823529412 18.2 18 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0142723579147087 0.0305406997182413 1.1631690776261 0.647058823529412 18.2 18 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0142723579147087 0.0305406997182413 1.1631690776261 0.647058823529412 18.2 18 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0142723579147087 0.0305406997182413 1.1631690776261 0.647058823529412 18.2 18 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0142723579147087 0.0305406997182413 1.1631690776261 0.647058823529412 18.2 18 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 9.63616142023553e-08 6.43767967182871e-07 1.16187953319414 0.646341463414634 18.2 18 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.05100630918499e-06 9.89349823040761e-06 1.16154226772732 0.646153846153846 18.2 18 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.05100630918499e-06 9.89349823040761e-06 1.16154226772732 0.646153846153846 18.2 18 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 3.23592720144314e-12 5.48181477101618e-11 1.16016928632339 0.645390070921986 18.2 18 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.78666753010885e-06 1.75783691588652e-05 1.15975802461254 0.645161290322581 18.2 18 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.25884734424712e-07 1.92404192053856e-06 1.15899502591213 0.644736842105263 18.2 18 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.22410102244402e-12 5.48181477101618e-11 1.15651394622201 0.643356643356643 18.2 18 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.10404529836312e-06 5.69223354916928e-06 1.15561603166749 0.642857142857143 18.2 18 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00197060347646917 0.00541345317956684 1.15561603166749 0.642857142857143 18.2 18 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00197060347646917 0.00541345317956684 1.15561603166749 0.642857142857143 18.2 18 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0280257835344631 0.0549636722614967 1.15561603166749 0.642857142857143 18.2 18 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0280257835344631 0.0549636722614967 1.15561603166749 0.642857142857143 18.2 18 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0280257835344631 0.0549636722614967 1.15561603166749 0.642857142857143 18.2 18 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0280257835344631 0.0549636722614967 1.15561603166749 0.642857142857143 18.2 18 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.30923077608591e-15 8.42573178043653e-14 1.15355611004242 0.641711229946524 18.2 18 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 4.21146877993081e-15 1.49823001846039e-13 1.15282468859583 0.641304347826087 18.2 18 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 3.74806801385742e-06 1.75444104727602e-05 1.15160347600198 0.640625 18.2 18 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 4.43740672054901e-05 0.000172055306903031 1.15047996041564 0.64 18.2 18 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00374083957909325 0.0095712100428742 1.15047996041564 0.64 18.2 18 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00374083957909325 0.0095712100428742 1.15047996041564 0.64 18.2 18 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.09127716610117e-06 5.64686329949807e-06 1.14848259937325 0.638888888888889 18.2 18 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 9.46128462121612e-13 1.70422886278361e-11 1.14816044436641 0.638709677419355 18.2 18 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.16075179567654e-10 2.44850504623607e-09 1.14526104930488 0.637096774193548 18.2 18 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.16075179567654e-10 2.44850504623607e-09 1.14526104930488 0.637096774193548 18.2 18 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.16075179567654e-10 2.44850504623607e-09 1.14526104930488 0.637096774193548 18.2 18 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.13993138983246e-28 4.06192942521053e-26 1.14394314245873 0.636363636363636 18.2 18 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00713980555372038 0.0168240468285439 1.14394314245873 0.636363636363636 18.2 18 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00713980555372038 0.0168240468285439 1.14394314245873 0.636363636363636 18.2 18 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00713980555372038 0.0168240468285439 1.14394314245873 0.636363636363636 18.2 18 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0559916461826439 0.100221525179751 1.14394314245873 0.636363636363636 18.2 18 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.97133834539948e-06 9.57411080376608e-06 1.13933974953133 0.633802816901408 18.2 18 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0019173137231822 0.00528747563582998 1.13849579416131 0.633333333333333 18.2 18 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.71047385110086e-63 1.21700214505826e-60 1.13673341677096 0.632352941176471 18.2 18 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.94809708284575e-10 7.06224439206393e-09 1.13456655932382 0.631147540983607 18.2 18 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 4.24792962174429e-05 0.000166066039883025 1.13183792402001 0.62962962962963 18.2 18 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00361727451108235 0.00941020407544823 1.13183792402001 0.62962962962963 18.2 18 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000276351536006667 0.000929664859899496 1.12874124023336 0.627906976744186 18.2 18 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.76651996409906e-16 7.85549346535299e-15 1.12855377282924 0.62780269058296 18.2 18 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000512786411123878 0.00164716718516767 1.12351558634339 0.625 18.2 18 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00685169151737102 0.0162770568100483 1.12351558634339 0.625 18.2 18 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00685169151737102 0.0162770568100483 1.12351558634339 0.625 18.2 18 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00685169151737102 0.0162770568100483 1.12351558634339 0.625 18.2 18 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0265950934051853 0.0528558909435457 1.12351558634339 0.625 18.2 18 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0265950934051853 0.0528558909435457 1.12351558634339 0.625 18.2 18 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0265950934051853 0.0528558909435457 1.12351558634339 0.625 18.2 18 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0265950934051853 0.0528558909435457 1.12351558634339 0.625 18.2 18 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0265950934051853 0.0528558909435457 1.12351558634339 0.625 18.2 18 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%REACT_212869.1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.114874599314251 0.184083958135337 1.12351558634339 0.625 18.2 18 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.37783601170509e-08 1.75319204386339e-07 1.11519324866678 0.62037037037037 18.2 18 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000139517911019544 0.000502617689571674 1.11452746165265 0.62 18.2 18 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000139517911019544 0.000502617689571674 1.11452746165265 0.62 18.2 18 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0130406210482426 0.028681304098376 1.11281543790203 0.619047619047619 18.2 18 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0130406210482426 0.028681304098376 1.11281543790203 0.619047619047619 18.2 18 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00177237885488998 0.00493560686987954 1.11029775591583 0.617647058823529 18.2 18 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00177237885488998 0.00493560686987954 1.11029775591583 0.617647058823529 18.2 18 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000256700378077114 0.000897288238263956 1.10917283417731 0.617021276595745 18.2 18 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000912447782031125 0.0027508754106574 1.10623073116888 0.615384615384615 18.2 18 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00651935279662786 0.0156706740364889 1.10623073116888 0.615384615384615 18.2 18 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0521572330190493 0.0951535161360349 1.10623073116888 0.615384615384615 18.2 18 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.80749718723552e-09 1.77384034305941e-08 1.10308803022806 0.613636363636364 18.2 18 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000472430612871739 0.00152788355026474 1.10308803022806 0.613636363636364 18.2 18 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00330218339475769 0.00866975455856125 1.10177012338191 0.612903225806452 18.2 18 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000245728676573799 0.000865524521694347 1.10058669682618 0.612244897959184 18.2 18 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0249660556949582 0.0501081766628005 1.09854857331354 0.611111111111111 18.2 18 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000869643770845244 0.00262739508686366 1.09611276716429 0.609756097560976 18.2 18 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 8.50187387292216e-14 1.85036937289468e-12 1.09569520039584 0.60952380952381 18.2 18 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.85675916765075e-05 7.54905227304864e-05 1.09420648409096 0.608695652173913 18.2 18 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.012293499265246 0.0276360970844313 1.09420648409096 0.608695652173913 18.2 18 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.012293499265246 0.0276360970844313 1.09420648409096 0.608695652173913 18.2 18 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 5.17119080995278e-06 2.29956391330088e-05 1.09222781052117 0.607594936708861 18.2 18 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00616212974639365 0.014837073822535 1.0914151410193 0.607142857142857 18.2 18 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.29871486498346e-46 6.16023750957153e-44 1.09100412379364 0.606914212548015 18.2 18 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.71456785043368e-12 9.34693109329554e-11 1.09036266740211 0.60655737704918 18.2 18 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00312690558771435 0.00822474427230595 1.0894696594845 0.606060606060606 18.2 18 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00312690558771435 0.00822474427230595 1.0894696594845 0.606060606060606 18.2 18 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00312690558771435 0.00822474427230595 1.0894696594845 0.606060606060606 18.2 18 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00160102597577544 0.00451818633312114 1.08803614677466 0.605263157894737 18.2 18 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 6.86927463844517e-14 1.80850416397398e-12 1.08674598533579 0.604545454545454 18.2 18 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.79799617640776e-12 4.91549204818302e-11 1.08606506679861 0.604166666666667 18.2 18 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000427822551247589 0.00139311553873071 1.08606506679861 0.604166666666667 18.2 18 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000427822551247589 0.00139311553873071 1.08606506679861 0.604166666666667 18.2 18 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.48682581346298e-06 1.1875010511939e-05 1.08266047411273 0.602272727272727 18.2 18 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00294745920167886 0.00785437161795695 1.07857496288966 0.6 18.2 18 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0115179694247878 0.0260159849071 1.07857496288966 0.6 18.2 18 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0232638162503317 0.0474275222410057 1.07857496288966 0.6 18.2 18 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0232638162503317 0.0474275222410057 1.07857496288966 0.6 18.2 18 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.103964763834746 0.169076410213535 1.07857496288966 0.6 18.2 18 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.25289546878937e-06 6.29989488370063e-06 1.07857496288966 0.6 18.2 18 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00579398804168072 0.0140900320768928 1.07857496288966 0.6 18.2 18 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0481474225198116 0.0890946453129935 1.07857496288966 0.6 18.2 18 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0481474225198116 0.0890946453129935 1.07857496288966 0.6 18.2 18 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0481474225198116 0.0890946453129935 1.07857496288966 0.6 18.2 18 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.21159749212115e-30 3.14710323128839e-28 1.07722842735546 0.599250936329588 18.2 18 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.23894101299142e-06 1.95210778688893e-05 1.07444249176748 0.597701149425287 18.2 18 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000382381204706208 0.00126541500999287 1.07166102081985 0.596153846153846 18.2 18 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.78846756023795e-35 1.60999822303643e-32 1.06795136294414 0.594090202177294 18.2 18 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00542491327683741 0.013448870370975 1.06733980702622 0.59375 18.2 18 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.7618477923099e-09 1.74104820031735e-08 1.06697738264353 0.593548387096774 18.2 18 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.06262995201109e-14 8.54533808178782e-13 1.06288141184232 0.591269841269841 18.2 18 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.06262995201109e-14 8.54533808178782e-13 1.06288141184232 0.591269841269841 18.2 18 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.06262995201109e-14 8.54533808178782e-13 1.06288141184232 0.591269841269841 18.2 18 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 5.06572792895595e-07 2.79400420267609e-06 1.06223291799739 0.590909090909091 18.2 18 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.27971411708211e-05 5.29370112967398e-05 1.06124845746171 0.590361445783133 18.2 18 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000176951737678938 0.000631083515581776 1.06089340612098 0.590163934426229 18.2 18 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.79432263157652e-06 8.83502112364492e-06 1.06059871350816 0.59 18.2 18 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00506194377746347 0.0126149667168661 1.05742643420555 0.588235294117647 18.2 18 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.37755590965744e-09 3.96768284040926e-08 1.05338531407483 0.585987261146497 18.2 18 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.99599516824571e-06 1.42585321886744e-05 1.05315400416835 0.585858585858586 18.2 18 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 9.20245078616622e-15 2.91001943749212e-13 1.05131855588523 0.584837545126354 18.2 18 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00116715860206189 0.00336889795280745 1.04861454725383 0.583333333333333 18.2 18 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0199120301122708 0.0409462700141059 1.04861454725383 0.583333333333333 18.2 18 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0199120301122708 0.0409462700141059 1.04861454725383 0.583333333333333 18.2 18 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0937103737819611 0.155600772335742 1.04861454725383 0.583333333333333 18.2 18 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0937103737819611 0.155600772335742 1.04861454725383 0.583333333333333 18.2 18 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0937103737819611 0.155600772335742 1.04861454725383 0.583333333333333 18.2 18 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0937103737819611 0.155600772335742 1.04861454725383 0.583333333333333 18.2 18 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.30251504567954e-07 1.93394193827242e-06 1.04378222215128 0.580645161290323 18.2 18 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0092441790912664 0.0211827163395686 1.04378222215128 0.580645161290323 18.2 18 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.6545247398181e-07 1.0279999386259e-06 1.04289691068211 0.580152671755725 18.2 18 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.6545247398181e-07 1.0279999386259e-06 1.04289691068211 0.580152671755725 18.2 18 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.95120918155758e-16 8.4138505010801e-15 1.04218132917252 0.579754601226994 18.2 18 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00437212796418865 0.0109341618506862 1.04073022734967 0.578947368421053 18.2 18 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00437212796418865 0.0109341618506862 1.04073022734967 0.578947368421053 18.2 18 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0404296706522281 0.0767085617841608 1.04073022734967 0.578947368421053 18.2 18 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0404296706522281 0.0767085617841608 1.04073022734967 0.578947368421053 18.2 18 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0404296706522281 0.0767085617841608 1.04073022734967 0.578947368421053 18.2 18 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00101237459258184 0.00301089763504892 1.03709131047083 0.576923076923077 18.2 18 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00101237459258184 0.00301089763504892 1.03709131047083 0.576923076923077 18.2 18 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0183342648268239 0.0378110997805368 1.03709131047083 0.576923076923077 18.2 18 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0183342648268239 0.0378110997805368 1.03709131047083 0.576923076923077 18.2 18 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00854363799779009 0.0196724868460442 1.03499617651028 0.575757575757576 18.2 18 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00854363799779009 0.0196724868460442 1.03499617651028 0.575757575757576 18.2 18 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.40190256385238e-08 1.07253083245265e-07 1.03034600113443 0.573170731707317 18.2 18 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00374642585655722 0.0095712100428742 1.0272142503711 0.571428571428571 18.2 18 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0843324989984977 0.141850054462012 1.0272142503711 0.571428571428571 18.2 18 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 6.21805528605482e-69 8.84829267205601e-66 1.02704846369416 0.571336346029697 18.2 18 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.43736340542513e-06 7.17673026638581e-06 1.0250919068786 0.570247933884298 18.2 18 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 5.77798488441937e-06 2.54553327880148e-05 1.02481421707584 0.570093457943925 18.2 18 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000809008758224862 0.00246513803630402 1.02278660274019 0.568965517241379 18.2 18 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000809008758224862 0.00246513803630402 1.02278660274019 0.568965517241379 18.2 18 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000809008758224862 0.00246513803630402 1.02278660274019 0.568965517241379 18.2 18 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.17418702158825e-05 8.78939810147749e-05 1.02180785957968 0.568421052631579 18.2 18 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.17418702158825e-05 8.78939810147749e-05 1.02180785957968 0.568421052631579 18.2 18 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 5.00142012635016e-06 2.23104101561012e-05 1.02027361354427 0.567567567567568 18.2 18 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0154513317888653 0.0325736964971189 1.01865413161801 0.566666666666667 18.2 18 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0154513317888653 0.0325736964971189 1.01865413161801 0.566666666666667 18.2 18 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000692859292065558 0.00215741525735074 1.01478827153597 0.564516129032258 18.2 18 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00142278336778524 0.00404115914642396 1.01320678332059 0.563636363636364 18.2 18 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00294154882876208 0.00785332829892767 1.01116402770905 0.5625 18.2 18 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0758575599529026 0.128201078162685 1.01116402770905 0.5625 18.2 18 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0758575599529026 0.128201078162685 1.01116402770905 0.5625 18.2 18 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0758575599529026 0.128201078162685 1.01116402770905 0.5625 18.2 18 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00613572064811508 0.0147985262411318 1.00842374579114 0.560975609756098 18.2 18 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0305953800781584 0.0584392293304958 1.00666996536368 0.56 18.2 18 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0129537840102039 0.028578658366698 1.00455511249527 0.558823529411765 18.2 18 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0129537840102039 0.028578658366698 1.00455511249527 0.558823529411765 18.2 18 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0129537840102039 0.028578658366698 1.00455511249527 0.558823529411765 18.2 18 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.40821170404067e-23 4.18192350323325e-21 1.00427732971921 0.558669001751314 18.2 18 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.000113092555563842 0.000413703615854362 1.0033255468741 0.558139534883721 18.2 18 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00563306752037103 0.0138443092944525 1.0033255468741 0.558139534883721 18.2 18 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00249158460308173 0.00667707135628117 1.0025216001218 0.557692307692308 18.2 18 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000211013330572166 0.000746945197522868 0.998680521194128 0.555555555555556 18.2 18 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00516774049089514 0.0128336731562719 0.998680521194128 0.555555555555556 18.2 18 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0118454081700916 0.0267131788051353 0.998680521194128 0.555555555555556 18.2 18 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0278263988908499 0.0549636722614967 0.998680521194128 0.555555555555556 18.2 18 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0682401831909299 0.115878019905362 0.998680521194128 0.555555555555556 18.2 18 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0682401831909299 0.115878019905362 0.998680521194128 0.555555555555556 18.2 18 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0682401831909299 0.115878019905362 0.998680521194128 0.555555555555556 18.2 18 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.184500708660423 0.271223665727047 0.998680521194128 0.555555555555556 18.2 18 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.184500708660423 0.271223665727047 0.998680521194128 0.555555555555556 18.2 18 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.184500708660423 0.271223665727047 0.998680521194128 0.555555555555556 18.2 18 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.184500708660423 0.271223665727047 0.998680521194128 0.555555555555556 18.2 18 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.184500708660423 0.271223665727047 0.998680521194128 0.555555555555556 18.2 18 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.4792040942257e-05 0.000137908284849113 0.992973775358733 0.552380952380952 18.2 18 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0252959477262478 0.0506987797386628 0.991793069323824 0.551724137931034 18.2 18 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00988775370857112 0.0225847087115517 0.988693715982187 0.55 18.2 18 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0229885886359497 0.0470010942944775 0.985794320920656 0.548387096774194 18.2 18 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 3.3793287225219e-08 2.4534616184432e-07 0.985499966092074 0.548223350253807 18.2 18 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 5.45287503311875e-05 0.00020858712828301 0.985236744947284 0.548076923076923 18.2 18 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00364062134604102 0.00945365725440944 0.983606098232708 0.547169811320755 18.2 18 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 5.31175860363132e-18 2.90716634344899e-16 0.982847781223978 0.546747967479675 18.2 18 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0208878945642515 0.0428292132059508 0.980522693536053 0.545454545454545 18.2 18 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.161532505017268 0.240691889674945 0.980522693536053 0.545454545454545 18.2 18 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.161532505017268 0.240691889674945 0.980522693536053 0.545454545454545 18.2 18 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.161532505017268 0.240691889674945 0.980522693536053 0.545454545454545 18.2 18 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.161532505017268 0.240691889674945 0.980522693536053 0.545454545454545 18.2 18 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.161532505017268 0.240691889674945 0.980522693536053 0.545454545454545 18.2 18 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000478996137272732 0.00154560431596167 0.976487620723148 0.54320987654321 18.2 18 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000184585416656812 0.00065666261975661 0.97530714729384 0.542553191489362 18.2 18 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0498109456446399 0.0920532151328864 0.973713508164275 0.541666666666667 18.2 18 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0172412057888577 0.035712133679104 0.971689155756449 0.540540540540541 18.2 18 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.142189038005358 0.214310607105134 0.967951889772771 0.538461538461538 18.2 18 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.142189038005358 0.214310607105134 0.967951889772771 0.538461538461538 18.2 18 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.142189038005358 0.214310607105134 0.967951889772771 0.538461538461538 18.2 18 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.142189038005358 0.214310607105134 0.967951889772771 0.538461538461538 18.2 18 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.142189038005358 0.214310607105134 0.967951889772771 0.538461538461538 18.2 18 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0142322130417307 0.0305406997182413 0.964579235104573 0.536585365853659 18.2 18 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 8.23262808040919e-32 1.46437871980278e-29 0.964491458306401 0.536536536536537 18.2 18 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.8974964511947e-07 1.76202455130345e-06 0.96435087827808 0.536458333333333 18.2 18 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0129322258209437 0.028578658366698 0.961520315754347 0.534883720930233 18.2 18 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0330003702188988 0.062864159064917 0.954988248391885 0.53125 18.2 18 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00299478513939531 0.00795683546408158 0.953285952048941 0.53030303030303 18.2 18 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0298137689375551 0.0570228403200819 0.951683790784993 0.529411764705882 18.2 18 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0298137689375551 0.0570228403200819 0.951683790784993 0.529411764705882 18.2 18 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.111473438495104 0.180668226627031 0.951683790784993 0.529411764705882 18.2 18 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.111473438495104 0.180668226627031 0.951683790784993 0.529411764705882 18.2 18 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 7.10481705376345e-14 1.80850416397398e-12 0.951209608527502 0.52914798206278 18.2 18 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0024906935790149 0.00667707135628117 0.950173181593271 0.528571428571429 18.2 18 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00188952993797288 0.00523113054812335 0.9461183884997 0.526315789473684 18.2 18 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0991407526783766 0.164234331852538 0.9461183884997 0.526315789473684 18.2 18 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0883771171627848 0.147779832811566 0.941613062840178 0.523809523809524 18.2 18 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0163693398676387 0.0339556423201892 0.937891272077964 0.521739130434783 18.2 18 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.014833495242345 0.031364136299936 0.936262988619495 0.520833333333333 18.2 18 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0134464069690261 0.029528143698957 0.934764967837704 0.52 18.2 18 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0567840406946313 0.101384805405847 0.929806002491085 0.517241379310345 18.2 18 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0567840406946313 0.101384805405847 0.929806002491085 0.517241379310345 18.2 18 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0510091760175264 0.094145340431829 0.927806419690029 0.516129032258065 18.2 18 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 2.81957583394159e-05 0.000112388134781481 0.926725899791322 0.515527950310559 18.2 18 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0458698756019614 0.0852125756939832 0.926049210561828 0.515151515151515 18.2 18 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00511720485616093 0.0127303890040507 0.924492825333993 0.514285714285714 18.2 18 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0412875603568113 0.0782319552433323 0.924492825333993 0.514285714285714 18.2 18 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 3.76701097532073e-05 0.000148487318979898 0.921005369545696 0.512345679012346 18.2 18 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.00466972648452905 0.0116579312061138 0.910189842100978 0.506329113924051 18.2 18 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00998004756487942 0.0227589866743965 0.898812469074716 0.5 18.2 18 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0860768744142509 0.144442679589008 0.898812469074716 0.5 18.2 18 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0860768744142509 0.144442679589008 0.898812469074716 0.5 18.2 18 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.096355602145275 0.159806552275905 0.898812469074716 0.5 18.2 18 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.200045577012219 0.29166481156597 0.898812469074716 0.5 18.2 18 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.200045577012219 0.29166481156597 0.898812469074716 0.5 18.2 18 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.200045577012219 0.29166481156597 0.898812469074716 0.5 18.2 18 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.200045577012219 0.29166481156597 0.898812469074716 0.5 18.2 18 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.200045577012219 0.29166481156597 0.898812469074716 0.5 18.2 18 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.200045577012219 0.29166481156597 0.898812469074716 0.5 18.2 18 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.200045577012219 0.29166481156597 0.898812469074716 0.5 18.2 18 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00238100578791954 0.00646597564162119 0.898812469074715 0.5 18.2 18 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00381974695400423 0.00972396057113647 0.898812469074715 0.5 18.2 18 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0690179818161539 0.117059103843131 0.898812469074715 0.5 18.2 18 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.121462624763775 0.193985763231034 0.898812469074715 0.5 18.2 18 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.154706693799278 0.231734342396182 0.898812469074715 0.5 18.2 18 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.175516184281089 0.26016617732499 0.898812469074715 0.5 18.2 18 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.175516184281089 0.26016617732499 0.898812469074715 0.5 18.2 18 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.229354636252575 0.330001665710227 0.898812469074715 0.5 18.2 18 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.229354636252575 0.330001665710227 0.898812469074715 0.5 18.2 18 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.2650366534861 0.370580293242682 0.898812469074715 0.5 18.2 18 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.2650366534861 0.370580293242682 0.898812469074715 0.5 18.2 18 2 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.2650366534861 0.370580293242682 0.898812469074715 0.5 18.2 18 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.2650366534861 0.370580293242682 0.898812469074715 0.5 18.2 18 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0770211440202919 0.130013152954775 0.898812469074715 0.5 18.2 18 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.95585886358556e-10 2.31932263573521e-09 0.889733555245678 0.494949494949495 18.2 18 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 4.95282309008301e-06 2.21869929922028e-05 0.88823820473266 0.494117647058824 18.2 18 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.014356083202898 0.0306737333299156 0.885786201406966 0.492753623188406 18.2 18 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0260040336890996 0.0520446412652443 0.883043829266387 0.491228070175439 18.2 18 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0287535377275837 0.0559730289826971 0.882470424182448 0.490909090909091 18.2 18 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000317606471440846 0.00106342119731841 0.882269908294199 0.49079754601227 18.2 18 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000381315411633168 0.00126482944231701 0.881853743243117 0.490566037735849 18.2 18 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000381315411633168 0.00126482944231701 0.881853743243117 0.490566037735849 18.2 18 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000457912334430523 0.00148430353506751 0.881416098705528 0.490322580645161 18.2 18 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0656809338733297 0.111932896888321 0.875765995508697 0.487179487179487 18.2 18 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0656809338733297 0.111932896888321 0.875765995508697 0.487179487179487 18.2 18 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.00292002142375516 0.00781050843233758 0.863426151394609 0.480314960629921 18.2 18 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.142622730097373 0.214310607105134 0.862859970311727 0.48 18.2 18 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.142622730097373 0.214310607105134 0.862859970311727 0.48 18.2 18 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.142622730097373 0.214310607105134 0.862859970311727 0.48 18.2 18 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.180957008562287 0.26767341287332 0.856011875309253 0.476190476190476 18.2 18 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.20471604080809 0.298168808669307 0.85150654964973 0.473684210526316 18.2 18 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00141227020526303 0.00401932100417857 0.846555930175023 0.47093023255814 18.2 18 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.232443069424188 0.333770421584883 0.845941147364438 0.470588235294118 18.2 18 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0436225249614169 0.0825463471011918 0.842636689757546 0.46875 18.2 18 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0862699739903064 0.144596199043823 0.838891637803068 0.466666666666667 18.2 18 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.265109443795538 0.370580293242682 0.838891637803068 0.466666666666667 18.2 18 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.265109443795538 0.370580293242682 0.838891637803068 0.466666666666667 18.2 18 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.265109443795538 0.370580293242682 0.838891637803068 0.466666666666667 18.2 18 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000535892614020626 0.00170980984249182 0.833233876910466 0.463519313304721 18.2 18 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.106217207157254 0.172542335370745 0.833045703044858 0.463414634146341 18.2 18 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.182280268342028 0.269350801506444 0.829673048376661 0.461538461538462 18.2 18 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.304068006178761 0.412084545516549 0.829673048376661 0.461538461538462 18.2 18 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.304068006178761 0.412084545516549 0.829673048376661 0.461538461538462 18.2 18 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.304068006178761 0.412084545516549 0.829673048376661 0.461538461538462 18.2 18 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.117994342582155 0.188658370218434 0.82967304837666 0.461538461538462 18.2 18 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0594672904155799 0.102696546433702 0.827478146132278 0.46031746031746 18.2 18 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00866195347681114 0.019880580318552 0.822856485772627 0.457746478873239 18.2 18 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00945615994757055 0.0216336263752297 0.821771400296883 0.457142857142857 18.2 18 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.145995302923508 0.219146957869358 0.821771400296883 0.457142857142857 18.2 18 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.162637727302758 0.241832273721865 0.817102244613378 0.454545454545455 18.2 18 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.162637727302758 0.241832273721865 0.817102244613378 0.454545454545455 18.2 18 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0878741985282491 0.147111746477292 0.817102244613378 0.454545454545455 18.2 18 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.230535661727714 0.331365905695492 0.817102244613378 0.454545454545455 18.2 18 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.351290110543459 0.467935361114031 0.817102244613378 0.454545454545455 18.2 18 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.351290110543459 0.467935361114031 0.817102244613378 0.454545454545455 18.2 18 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.351290110543459 0.467935361114031 0.817102244613378 0.454545454545455 18.2 18 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.351290110543459 0.467935361114031 0.817102244613378 0.454545454545455 18.2 18 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.351290110543459 0.467935361114031 0.817102244613378 0.454545454545455 18.2 18 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0135161935163209 0.029635660051964 0.813523694636969 0.452554744525547 18.2 18 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.26022533656745 0.36627166561373 0.808931222167244 0.45 18.2 18 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.26022533656745 0.36627166561373 0.808931222167244 0.45 18.2 18 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.26022533656745 0.36627166561373 0.808931222167244 0.45 18.2 18 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0175633121600108 0.0363264436100224 0.80628765608173 0.448529411764706 18.2 18 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0208116573871831 0.0427344710850816 0.800402344723469 0.445255474452555 18.2 18 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.117322677810863 0.18779546740704 0.798944416955303 0.444444444444444 18.2 18 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0318969266612105 0.0608436013926308 0.795670054590732 0.442622950819672 18.2 18 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0544049373770122 0.0991270497919185 0.794739446339748 0.442105263157895 18.2 18 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.253588548418097 0.357992563887849 0.79095497278575 0.44 18.2 18 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.176246597651194 0.260977011922631 0.789201192358287 0.439024390243902 18.2 18 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.334793090084553 0.44902032722933 0.786460910440376 0.4375 18.2 18 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.334793090084553 0.44902032722933 0.786460910440376 0.4375 18.2 18 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.334793090084553 0.44902032722933 0.786460910440376 0.4375 18.2 18 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.334793090084553 0.44902032722933 0.786460910440376 0.4375 18.2 18 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.334793090084553 0.44902032722933 0.786460910440376 0.4375 18.2 18 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0840993902962309 0.141625363776966 0.782495561312105 0.435294117647059 18.2 18 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0840993902962309 0.141625363776966 0.782495561312105 0.435294117647059 18.2 18 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.172834275003141 0.256725650657067 0.78157606006497 0.434782608695652 18.2 18 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.284452725465646 0.396450762328711 0.78157606006497 0.434782608695652 18.2 18 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.215773015880339 0.31140466693481 0.777351324605159 0.432432432432432 18.2 18 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0902552922099538 0.150566566019653 0.776247132382709 0.431818181818182 18.2 18 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00860626978951165 0.0197846880621568 0.775446051750735 0.431372549019608 18.2 18 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0887272717290894 0.148191206186026 0.773172016408357 0.43010752688172 18.2 18 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.185845545931981 0.272918691291237 0.770410687778328 0.428571428571429 18.2 18 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.27435872367325 0.382757317438269 0.770410687778328 0.428571428571429 18.2 18 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.382084828053668 0.489384977786111 0.770410687778328 0.428571428571429 18.2 18 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.382084828053668 0.489384977786111 0.770410687778328 0.428571428571429 18.2 18 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.382084828053668 0.489384977786111 0.770410687778328 0.428571428571429 18.2 18 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.382084828053668 0.489384977786111 0.770410687778328 0.428571428571429 18.2 18 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.382084828053668 0.489384977786111 0.770410687778328 0.428571428571429 18.2 18 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.382084828053668 0.489384977786111 0.770410687778328 0.428571428571429 18.2 18 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.382084828053668 0.489384977786111 0.770410687778328 0.428571428571429 18.2 18 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.382084828053668 0.489384977786111 0.770410687778328 0.428571428571429 18.2 18 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.210000028088408 0.305552188108184 0.770410687778328 0.428571428571429 18.2 18 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.305881287140547 0.414147546718362 0.760533627678605 0.423076923076923 18.2 18 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.224332158172232 0.323429241214879 0.758997196107538 0.422222222222222 18.2 18 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.293225667124435 0.398529249587461 0.753842715998148 0.419354838709677 18.2 18 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.293225667124435 0.398529249587461 0.753842715998148 0.419354838709677 18.2 18 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.293225667124435 0.398529249587461 0.753842715998148 0.419354838709677 18.2 18 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0281109181561686 0.0549636722614967 0.750815235211007 0.417670682730924 18.2 18 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.438386877894091 0.556489319574748 0.749010390895596 0.416666666666667 18.2 18 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.141725446263845 0.214310607105134 0.744470933981077 0.414141414141414 18.2 18 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.40643810454681 0.520109193138588 0.740198503943883 0.411764705882353 18.2 18 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.273989212637635 0.382616927952262 0.733724464550788 0.408163265306122 18.2 18 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.360487036221189 0.471482585057676 0.732365715542361 0.407407407407407 18.2 18 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.34240225536067 0.458361626884509 0.730285131123206 0.40625 18.2 18 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.326385105741525 0.439816293058892 0.728766866817337 0.405405405405405 18.2 18 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.128752285402349 0.199146197964719 0.719049975259772 0.4 18.2 18 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.338677695452111 0.453802599461727 0.711559871350816 0.395833333333333 18.2 18 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.367620992391916 0.474759097143601 0.703418454058473 0.391304347826087 18.2 18 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.477587335670342 0.59562382003409 0.69907636483589 0.388888888888889 18.2 18 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.477587335670342 0.59562382003409 0.69907636483589 0.388888888888889 18.2 18 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.430813755707126 0.547853417668668 0.695854814767522 0.387096774193548 18.2 18 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.522336172716173 0.641315249158856 0.69139420698055 0.384615384615385 18.2 18 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.522336172716173 0.641315249158856 0.69139420698055 0.384615384615385 18.2 18 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.492333290039217 0.610270271538158 0.684809500247402 0.380952380952381 18.2 18 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.431565987204645 0.548319999814473 0.678349033263936 0.377358490566038 18.2 18 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.421482736357121 0.536466846007319 0.677793009466179 0.377049180327869 18.2 18 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.483860655914998 0.60143892284461 0.674109351806037 0.375 18.2 18 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.505105547049612 0.622762294230435 0.674109351806037 0.375 18.2 18 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.546164945760963 0.668265449542433 0.66228287194979 0.368421052631579 18.2 18 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.150737060476758 0.226026171821314 0.662052111367229 0.368292682926829 18.2 18 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.496070343565996 0.614367361962065 0.660352018095709 0.36734693877551 18.2 18 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.526558491704645 0.645385644871413 0.659129143988125 0.366666666666667 18.2 18 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.526558491704645 0.645385644871413 0.659129143988125 0.366666666666667 18.2 18 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.555729725621203 0.679384363882278 0.653681795690702 0.363636363636364 18.2 18 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.530574322802517 0.64974807344921 0.65020476486256 0.361702127659574 18.2 18 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.600253586417565 0.703013048125263 0.64200890648194 0.357142857142857 18.2 18 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.600253586417565 0.703013048125263 0.64200890648194 0.357142857142857 18.2 18 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.579218096503282 0.693109297840683 0.637866913536895 0.354838709677419 18.2 18 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.569683183397286 0.693109297840683 0.635745404955287 0.353658536585366 18.2 18 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.594460374815265 0.697951413665117 0.630095339145161 0.350515463917526 18.2 18 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.603489216713635 0.706221344887749 0.627078466796313 0.348837209302326 18.2 18 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.631959990352363 0.738931032269032 0.618854486903902 0.344262295081967 18.2 18 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.670660760573317 0.782896031415775 0.599208312716477 0.333333333333333 18.2 18 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.670346170846803 0.782896031415775 0.599208312716477 0.333333333333333 18.2 18 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.673871519522818 0.784071277416982 0.599208312716477 0.333333333333333 18.2 18 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.720719739035552 0.829089885729661 0.575239980207818 0.32 18.2 18 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.830742993155049 0.922111762293007 0.570400220758954 0.317307692307692 18.2 18 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.726328721181444 0.834400665594483 0.56767103309982 0.315789473684211 18.2 18 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.796231816299001 0.896501374237805 0.544734829742252 0.303030303030303 18.2 18 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.955493053935324 1 0.54122041148585 0.301075268817204 18.2 18 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.775940466362752 0.877713262030362 0.539287481444829 0.3 18.2 18 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.784375660752175 0.884442603209466 0.528713217102774 0.294117647058824 18.2 18 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.929694425595372 1 0.506373222013924 0.28169014084507 18.2 18 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.922400177173408 1 0.486856754082138 0.270833333333333 18.2 18 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.982157738092567 1 0.455094921050489 0.253164556962025 18.2 18 2 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.89482419510126 0.980242363070896 0.449406234537358 0.25 18.2 18 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999777952618229 1 0.447335238064835 0.248847926267281 18.2 18 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.92840618174395 1 0.431429985155863 0.24 18.2 18 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.95620396749023 1 0.422970573682219 0.235294117647059 18.2 18 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.950571057196092 1 0.419445818901534 0.233333333333333 18.2 18 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.965528243001412 1 0.410885700148441 0.228571428571429 18.2 18 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999998988612 1 0.393809586965726 0.219072164948454 18.2 18 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999869411606 1 0.391625432953983 0.217857142857143 18.2 18 2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.952512869121724 1 0.390788030032485 0.217391304347826 18.2 18 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.967034915490856 1 0.385205343889164 0.214285714285714 18.2 18 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.983718021941978 1 0.37844735539988 0.210526315789474 18.2 18 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.994129644009109 1 0.373091968295165 0.207547169811321 18.2 18 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.985607568088762 1 0.347927407383761 0.193548387096774 18.2 18 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.985607568088762 1 0.347927407383761 0.193548387096774 18.2 18 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.996915264286016 1 0.337054675903018 0.1875 18.2 18 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.318470916834198 0.177162048698573 18.2 18 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.995544365331068 1 0.308164275111331 0.171428571428571 18.2 18 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999988258141 1 0.306413341730017 0.170454545454545 18.2 18 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999681995948 1 0.266314805651768 0.148148148148148 18.2 18 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.263304918607783 0.146473779385172 18.2 18 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999567712667 1 0.239683325086591 0.133333333333333 18.2 18 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 2.68626198420871e-05 0.000101393920518011 1.60273131809115 1 18.5 18 5 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.000182136540669297 0.000587710424880747 1.60273131809115 1 18.5 18 5 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.000182136540669297 0.000587710424880747 1.60273131809115 1 18.5 18 5 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000182136540669297 0.000587710424880747 1.60273131809115 1 18.5 18 5 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 8.60813675804937e-08 4.57066365921801e-07 1.60273131809115 1 18.5 18 5 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 6.99492390451892e-05 0.000245772264595813 1.60273131809115 1 18.5 18 5 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 6.99492390451892e-05 0.000245772264595813 1.60273131809115 1 18.5 18 5 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.000474231760581904 0.001420698516438 1.60273131809115 1 18.5 18 5 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.000474231760581904 0.001420698516438 1.60273131809115 1 18.5 18 5 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.000474231760581904 0.001420698516438 1.60273131809115 1 18.5 18 5 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000474231760581904 0.001420698516438 1.60273131809115 1 18.5 18 5 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000474231760581904 0.001420698516438 1.60273131809115 1 18.5 18 5 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00123470627340573 0.00335302867758846 1.60273131809115 1 18.5 18 5 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00123470627340573 0.00335302867758846 1.60273131809115 1 18.5 18 5 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00123470627340573 0.00335302867758846 1.60273131809115 1 18.5 18 5 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.00321452006304693 0.00780590793466858 1.60273131809115 1 18.5 18 5 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00321452006304693 0.00780590793466858 1.60273131809115 1 18.5 18 5 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.00836850917326648 0.0179754054867357 1.60273131809115 1 18.5 18 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.04437691223043e-08 6.40581183665474e-08 1.53304734773936 0.956521739130435 18.5 18 5 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 6.48806361788052e-08 3.48396774650716e-07 1.52641077913443 0.952380952380952 18.5 18 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.61197664840798e-07 8.37168894410423e-07 1.52259475218659 0.95 18.5 18 5 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 3.99539391390307e-07 1.97411303454308e-06 1.51837703819161 0.947368421052632 18.5 18 5 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 9.87667354806162e-07 4.49025765459798e-06 1.5136906893083 0.944444444444444 18.5 18 5 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 9.87667354806162e-07 4.49025765459798e-06 1.5136906893083 0.944444444444444 18.5 18 5 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.98057510373097e-06 2.43153096360262e-05 1.50256061071045 0.9375 18.5 18 5 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.98057510373097e-06 2.43153096360262e-05 1.50256061071045 0.9375 18.5 18 5 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 5.98057510373097e-06 2.43153096360262e-05 1.50256061071045 0.9375 18.5 18 5 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 5.98057510373097e-06 2.43153096360262e-05 1.50256061071045 0.9375 18.5 18 5 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 5.98057510373097e-06 2.43153096360262e-05 1.50256061071045 0.9375 18.5 18 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 3.56829778925963e-05 0.000130531818871888 1.48825050965606 0.928571428571429 18.5 18 5 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 3.56829778925963e-05 0.000130531818871888 1.48825050965606 0.928571428571429 18.5 18 5 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 3.56829778925963e-05 0.000130531818871888 1.48825050965606 0.928571428571429 18.5 18 5 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.37085480607534e-08 8.10217830314573e-08 1.4794442936226 0.923076923076923 18.5 18 5 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 8.65690159568234e-05 0.000293304070729904 1.4794442936226 0.923076923076923 18.5 18 5 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 8.65690159568234e-05 0.000293304070729904 1.4794442936226 0.923076923076923 18.5 18 5 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 8.65690159568234e-05 0.000293304070729904 1.4794442936226 0.923076923076923 18.5 18 5 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 8.65690159568234e-05 0.000293304070729904 1.4794442936226 0.923076923076923 18.5 18 5 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 3.36711929627117e-11 3.42243625613848e-10 1.46917037491688 0.916666666666667 18.5 18 5 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 7.93645275969168e-08 4.22980235095178e-07 1.46917037491688 0.916666666666667 18.5 18 5 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000208880176929729 0.000666449533118845 1.46917037491688 0.916666666666667 18.5 18 5 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000208880176929729 0.000666449533118845 1.46917037491688 0.916666666666667 18.5 18 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000208880176929729 0.000666449533118845 1.46917037491688 0.916666666666667 18.5 18 5 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000208880176929729 0.000666449533118845 1.46917037491688 0.916666666666667 18.5 18 5 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 1.89993652550249e-07 9.69035726089622e-07 1.46336337738757 0.91304347826087 18.5 18 5 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.89993652550249e-07 9.69035726089622e-07 1.46336337738757 0.91304347826087 18.5 18 5 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00050081543107621 0.00147548728451645 1.45702847099195 0.909090909090909 18.5 18 5 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00050081543107621 0.00147548728451645 1.45702847099195 0.909090909090909 18.5 18 5 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00050081543107621 0.00147548728451645 1.45702847099195 0.909090909090909 18.5 18 5 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00050081543107621 0.00147548728451645 1.45702847099195 0.909090909090909 18.5 18 5 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00050081543107621 0.00147548728451645 1.45702847099195 0.909090909090909 18.5 18 5 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.07620943712973e-06 4.87721665297966e-06 1.4500902401777 0.904761904761905 18.5 18 5 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 2.54461493033589e-06 1.10395946520365e-05 1.44245818628203 0.9 18.5 18 5 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00119182225528627 0.00325520742662641 1.44245818628203 0.9 18.5 18 5 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00119182225528627 0.00325520742662641 1.44245818628203 0.9 18.5 18 5 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00119182225528627 0.00325520742662641 1.44245818628203 0.9 18.5 18 5 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00119182225528627 0.00325520742662641 1.44245818628203 0.9 18.5 18 5 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00119182225528627 0.00325520742662641 1.44245818628203 0.9 18.5 18 5 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 1.40080289452511e-05 5.41669162747075e-05 1.42465006052546 0.888888888888889 18.5 18 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00281099351988275 0.00688475693423952 1.42465006052546 0.888888888888889 18.5 18 5 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00281099351988275 0.00688475693423952 1.42465006052546 0.888888888888889 18.5 18 5 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00281099351988275 0.00688475693423952 1.42465006052546 0.888888888888889 18.5 18 5 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00281099351988275 0.00688475693423952 1.42465006052546 0.888888888888889 18.5 18 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00281099351988275 0.00688475693423952 1.42465006052546 0.888888888888889 18.5 18 5 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00281099351988275 0.00688475693423952 1.42465006052546 0.888888888888889 18.5 18 5 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00281099351988275 0.00688475693423952 1.42465006052546 0.888888888888889 18.5 18 5 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00281099351988275 0.00688475693423952 1.42465006052546 0.888888888888889 18.5 18 5 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 3.25770818952962e-05 0.000121992598781596 1.41417469243336 0.882352941176471 18.5 18 5 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 4.19097106480151e-07 2.06358194644033e-06 1.41040355992021 0.88 18.5 18 5 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 9.64397527223573e-07 4.4126613544667e-06 1.40238990332975 0.875 18.5 18 5 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 9.64397527223573e-07 4.4126613544667e-06 1.40238990332975 0.875 18.5 18 5 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 7.52458863393983e-05 0.000259890524905252 1.40238990332975 0.875 18.5 18 5 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 7.52458863393983e-05 0.000259890524905252 1.40238990332975 0.875 18.5 18 5 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 7.52458863393983e-05 0.000259890524905252 1.40238990332975 0.875 18.5 18 5 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0065580278631725 0.0146270746854145 1.40238990332975 0.875 18.5 18 5 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 5.76445924440324e-12 7.13289174329201e-11 1.39812732003696 0.872340425531915 18.5 18 5 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 2.20728777851462e-06 9.69435342230343e-06 1.39367940703578 0.869565217391304 18.5 18 5 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000172470530641241 0.00056549669378453 1.38903380901233 0.866666666666667 18.5 18 5 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000172470530641241 0.00056549669378453 1.38903380901233 0.866666666666667 18.5 18 5 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000172470530641241 0.00056549669378453 1.38903380901233 0.866666666666667 18.5 18 5 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.98621059017957e-11 3.05710623728455e-10 1.38903380901233 0.866666666666667 18.5 18 5 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 5.02244904120604e-06 2.10204264283417e-05 1.38417704744235 0.863636363636364 18.5 18 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.53187553099557e-07 8.01418706105402e-07 1.38166492938892 0.862068965517241 18.5 18 5 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 3.45437395874547e-07 1.71274360393547e-06 1.37376970122098 0.857142857142857 18.5 18 5 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.13550478895727e-05 4.4269131909211e-05 1.37376970122098 0.857142857142857 18.5 18 5 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 1.13550478895727e-05 4.4269131909211e-05 1.37376970122098 0.857142857142857 18.5 18 5 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.13550478895727e-05 4.4269131909211e-05 1.37376970122098 0.857142857142857 18.5 18 5 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000391885244342186 0.00119411713640028 1.37376970122098 0.857142857142857 18.5 18 5 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0150934028008942 0.0302505805432006 1.37376970122098 0.857142857142857 18.5 18 5 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0150934028008942 0.0302505805432006 1.37376970122098 0.857142857142857 18.5 18 5 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0150934028008942 0.0302505805432006 1.37376970122098 0.857142857142857 18.5 18 5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0150934028008942 0.0302505805432006 1.37376970122098 0.857142857142857 18.5 18 5 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0150934028008942 0.0302505805432006 1.37376970122098 0.857142857142857 18.5 18 5 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0150934028008942 0.0302505805432006 1.37376970122098 0.857142857142857 18.5 18 5 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0150934028008942 0.0302505805432006 1.37376970122098 0.857142857142857 18.5 18 5 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0150934028008942 0.0302505805432006 1.37376970122098 0.857142857142857 18.5 18 5 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.47607453630439e-11 2.57186428113952e-10 1.36899966753619 0.854166666666667 18.5 18 5 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 7.69644445252538e-10 5.47602022797181e-09 1.36818527154122 0.853658536585366 18.5 18 5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 7.69644445252538e-10 5.47602022797181e-09 1.36818527154122 0.853658536585366 18.5 18 5 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 7.74733530180758e-07 3.68710974397063e-06 1.3652896413369 0.851851851851852 18.5 18 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 7.74733530180758e-07 3.68710974397063e-06 1.3652896413369 0.851851851851852 18.5 18 5 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 2.54922156870362e-05 9.64771886240758e-05 1.36232162037747 0.85 18.5 18 5 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.69558282106751e-18 6.34951145889229e-17 1.35760770473603 0.847058823529412 18.5 18 5 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.72739424930408e-06 7.65157074762137e-06 1.35615726915405 0.846153846153846 18.5 18 5 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000881591562280714 0.00250400158308474 1.35615726915405 0.846153846153846 18.5 18 5 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000881591562280714 0.00250400158308474 1.35615726915405 0.846153846153846 18.5 18 5 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 5.6788156419439e-05 0.000203039061771009 1.34966847839254 0.842105263157895 18.5 18 5 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 5.6788156419439e-05 0.000203039061771009 1.34966847839254 0.842105263157895 18.5 18 5 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.03158809684966e-13 2.1587497967898e-12 1.34832952156874 0.841269841269841 18.5 18 5 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 3.82722473612652e-06 1.61606551914185e-05 1.34629430719656 0.84 18.5 18 5 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.82722473612652e-06 1.61606551914185e-05 1.34629430719656 0.84 18.5 18 5 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.82722473612652e-06 1.61606551914185e-05 1.34629430719656 0.84 18.5 18 5 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 3.82722473612652e-06 1.61606551914185e-05 1.34629430719656 0.84 18.5 18 5 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.86171215047814e-08 1.09471751658281e-07 1.34282894218447 0.837837837837838 18.5 18 5 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 9.50227791950626e-11 9.26146676675165e-10 1.34106089881096 0.836734693877551 18.5 18 5 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 4.08128545324436e-08 2.33239726906294e-07 1.33560943174262 0.833333333333333 18.5 18 5 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 4.08128545324436e-08 2.33239726906294e-07 1.33560943174262 0.833333333333333 18.5 18 5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.81179547084372e-07 2.82258872184663e-06 1.33560943174262 0.833333333333333 18.5 18 5 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 8.42173903496986e-06 3.34752364434696e-05 1.33560943174262 0.833333333333333 18.5 18 5 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 8.42173903496986e-06 3.34752364434696e-05 1.33560943174262 0.833333333333333 18.5 18 5 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000125422346645521 0.000419943527709592 1.33560943174262 0.833333333333333 18.5 18 5 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000125422346645521 0.000419943527709592 1.33560943174262 0.833333333333333 18.5 18 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000125422346645521 0.000419943527709592 1.33560943174262 0.833333333333333 18.5 18 5 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00196049170180861 0.00501758937351376 1.33560943174262 0.833333333333333 18.5 18 5 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00196049170180861 0.00501758937351376 1.33560943174262 0.833333333333333 18.5 18 5 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00196049170180861 0.00501758937351376 1.33560943174262 0.833333333333333 18.5 18 5 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00196049170180861 0.00501758937351376 1.33560943174262 0.833333333333333 18.5 18 5 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00196049170180861 0.00501758937351376 1.33560943174262 0.833333333333333 18.5 18 5 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00196049170180861 0.00501758937351376 1.33560943174262 0.833333333333333 18.5 18 5 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00196049170180861 0.00501758937351376 1.33560943174262 0.833333333333333 18.5 18 5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00196049170180861 0.00501758937351376 1.33560943174262 0.833333333333333 18.5 18 5 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 VITAMINS%REACTOME%REACT_213027.1 VITAMINS 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0341384547243642 0.0638357701350463 1.33560943174262 0.833333333333333 18.5 18 5 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.2682366411945e-06 5.71107829246765e-06 1.32639833221336 0.827586206896552 18.5 18 5 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 9.83804684044777e-10 6.96494559898367e-09 1.32399543668399 0.826086956521739 18.5 18 5 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.83944650389903e-05 7.01751306983462e-05 1.32399543668399 0.826086956521739 18.5 18 5 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 5.07279301684197e-17 1.53586903467364e-15 1.32318515795897 0.825581395348837 18.5 18 5 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.37218901690662e-08 8.10217830314573e-08 1.3222533374252 0.825 18.5 18 5 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00027436697374521 0.000852454593099199 1.31989637960447 0.823529411764706 18.5 18 5 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00027436697374521 0.000852454593099199 1.31989637960447 0.823529411764706 18.5 18 5 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00027436697374521 0.000852454593099199 1.31989637960447 0.823529411764706 18.5 18 5 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00027436697374521 0.000852454593099199 1.31989637960447 0.823529411764706 18.5 18 5 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00027436697374521 0.000852454593099199 1.31989637960447 0.823529411764706 18.5 18 5 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.12628030211983e-09 1.42051496240212e-08 1.31780130598605 0.822222222222222 18.5 18 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 2.74949574798932e-06 1.18921958947988e-05 1.31652929700344 0.821428571428571 18.5 18 5 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.76057191461666e-13 5.10168030454482e-12 1.31567496261213 0.82089552238806 18.5 18 5 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.76057191461666e-13 5.10168030454482e-12 1.31567496261213 0.82089552238806 18.5 18 5 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.76057191461666e-13 5.10168030454482e-12 1.31567496261213 0.82089552238806 18.5 18 5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.5747244459989e-09 2.95901494848019e-08 1.31132562389276 0.818181818181818 18.5 18 5 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 3.98517427072231e-05 0.000145035882026543 1.31132562389276 0.818181818181818 18.5 18 5 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00430135296423152 0.0101003717295404 1.31132562389276 0.818181818181818 18.5 18 5 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00430135296423152 0.0101003717295404 1.31132562389276 0.818181818181818 18.5 18 5 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00430135296423152 0.0101003717295404 1.31132562389276 0.818181818181818 18.5 18 5 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00430135296423152 0.0101003717295404 1.31132562389276 0.818181818181818 18.5 18 5 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00430135296423152 0.0101003717295404 1.31132562389276 0.818181818181818 18.5 18 5 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 8.08496501900155e-12 9.35358148133269e-11 1.30889724310777 0.816666666666667 18.5 18 5 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 8.08496501900155e-12 9.35358148133269e-11 1.30889724310777 0.816666666666667 18.5 18 5 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 8.08496501900155e-12 9.35358148133269e-11 1.30889724310777 0.816666666666667 18.5 18 5 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 8.08496501900155e-12 9.35358148133269e-11 1.30889724310777 0.816666666666667 18.5 18 5 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 8.08496501900155e-12 9.35358148133269e-11 1.30889724310777 0.816666666666667 18.5 18 5 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 8.08496501900155e-12 9.35358148133269e-11 1.30889724310777 0.816666666666667 18.5 18 5 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 8.08496501900155e-12 9.35358148133269e-11 1.30889724310777 0.816666666666667 18.5 18 5 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 6.36383161255309e-08 3.44324425272359e-07 1.30749133844278 0.815789473684211 18.5 18 5 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 5.91910141344675e-06 2.43153096360262e-05 1.30592922214834 0.814814814814815 18.5 18 5 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.72724589640633e-11 1.83423202282553e-10 1.30391700454873 0.813559322033898 18.5 18 5 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.72724589640633e-11 1.83423202282553e-10 1.30391700454873 0.813559322033898 18.5 18 5 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 8.92297948860766e-07 4.10919087776333e-06 1.30221919594906 0.8125 18.5 18 5 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000593777322615894 0.0017208658453817 1.30221919594906 0.8125 18.5 18 5 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000593777322615894 0.0017208658453817 1.30221919594906 0.8125 18.5 18 5 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000593777322615894 0.0017208658453817 1.30221919594906 0.8125 18.5 18 5 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.42393016598103e-08 2.46872652007491e-07 1.29000325602458 0.804878048780488 18.5 18 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.42393016598103e-08 2.46872652007491e-07 1.29000325602458 0.804878048780488 18.5 18 5 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 4.42393016598103e-08 2.46872652007491e-07 1.29000325602458 0.804878048780488 18.5 18 5 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.64603472598818e-10 1.51116607424592e-09 1.28790909489467 0.803571428571429 18.5 18 5 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.036106474073e-17 6.58495343774064e-16 1.28218505447292 0.8 18.5 18 5 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 8.15650093463295e-16 2.11030924181503e-14 1.28218505447292 0.8 18.5 18 5 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 5.16938457880035e-15 1.1676244850211e-13 1.28218505447292 0.8 18.5 18 5 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 5.16938457880035e-15 1.1676244850211e-13 1.28218505447292 0.8 18.5 18 5 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 5.16938457880035e-15 1.1676244850211e-13 1.28218505447292 0.8 18.5 18 5 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 6.09292265820744e-07 2.94905746347931e-06 1.28218505447292 0.8 18.5 18 5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 4.01646501763504e-06 1.68596746905447e-05 1.28218505447292 0.8 18.5 18 5 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00018197191934905 0.000587710424880747 1.28218505447292 0.8 18.5 18 5 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00126954409914596 0.00341504962775936 1.28218505447292 0.8 18.5 18 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00126954409914596 0.00341504962775936 1.28218505447292 0.8 18.5 18 5 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00126954409914596 0.00341504962775936 1.28218505447292 0.8 18.5 18 5 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00126954409914596 0.00341504962775936 1.28218505447292 0.8 18.5 18 5 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00126954409914596 0.00341504962775936 1.28218505447292 0.8 18.5 18 5 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00928767857826871 0.0196672122274946 1.28218505447292 0.8 18.5 18 5 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00928767857826871 0.0196672122274946 1.28218505447292 0.8 18.5 18 5 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00928767857826871 0.0196672122274946 1.28218505447292 0.8 18.5 18 5 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00928767857826871 0.0196672122274946 1.28218505447292 0.8 18.5 18 5 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00928767857826871 0.0196672122274946 1.28218505447292 0.8 18.5 18 5 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.77574117577828e-12 3.62374283773623e-11 1.27753945644946 0.797101449275362 18.5 18 5 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 8.90049388979686e-17 2.63862558441269e-15 1.27564329399091 0.795918367346939 18.5 18 5 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 3.01007764791162e-08 1.74119532234888e-07 1.27489991211796 0.795454545454545 18.5 18 5 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 3.01007764791162e-08 1.74119532234888e-07 1.27489991211796 0.795454545454545 18.5 18 5 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 9.09987648311155e-13 1.54156240898425e-11 1.27340296505872 0.794520547945205 18.5 18 5 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 6.27149936777585e-08 3.40623801539887e-07 1.26727592593253 0.790697674418605 18.5 18 5 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 3.13483703232957e-09 2.04627206284632e-08 1.26369200080263 0.788461538461538 18.5 18 5 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 3.13483703232957e-09 2.04627206284632e-08 1.26369200080263 0.788461538461538 18.5 18 5 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.7843829420375e-20 8.75578250523919e-19 1.2619931638513 0.78740157480315 18.5 18 5 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.58594477804335e-10 1.46545416828291e-09 1.26116562735041 0.786885245901639 18.5 18 5 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.58594477804335e-10 1.46545416828291e-09 1.26116562735041 0.786885245901639 18.5 18 5 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.58594477804335e-10 1.46545416828291e-09 1.26116562735041 0.786885245901639 18.5 18 5 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.27620762729534e-12 1.95273489638847e-11 1.26081530356504 0.786666666666667 18.5 18 5 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.27620762729534e-12 1.95273489638847e-11 1.26081530356504 0.786666666666667 18.5 18 5 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.27620762729534e-12 1.95273489638847e-11 1.26081530356504 0.786666666666667 18.5 18 5 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.27620762729534e-12 1.95273489638847e-11 1.26081530356504 0.786666666666667 18.5 18 5 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.27620762729534e-12 1.95273489638847e-11 1.26081530356504 0.786666666666667 18.5 18 5 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.27620762729534e-12 1.95273489638847e-11 1.26081530356504 0.786666666666667 18.5 18 5 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 1.75409888534572e-05 6.70989976840579e-05 1.2592888927859 0.785714285714286 18.5 18 5 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.75409888534572e-05 6.70989976840579e-05 1.2592888927859 0.785714285714286 18.5 18 5 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 1.75409888534572e-05 6.70989976840579e-05 1.2592888927859 0.785714285714286 18.5 18 5 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00267718139472198 0.0066835598678761 1.2592888927859 0.785714285714286 18.5 18 5 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00267718139472198 0.0066835598678761 1.2592888927859 0.785714285714286 18.5 18 5 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00267718139472198 0.0066835598678761 1.2592888927859 0.785714285714286 18.5 18 5 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00267718139472198 0.0066835598678761 1.2592888927859 0.785714285714286 18.5 18 5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 3.26697237715329e-10 2.40875735372494e-09 1.25547286583806 0.783333333333333 18.5 18 5 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.66400973585484e-11 1.79385291978897e-10 1.2543114663322 0.782608695652174 18.5 18 5 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.66400973585484e-11 1.79385291978897e-10 1.2543114663322 0.782608695652174 18.5 18 5 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 4.15318564638276e-08 2.35457497004091e-07 1.2543114663322 0.782608695652174 18.5 18 5 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.32960521357095e-08 7.98324143000617e-08 1.25013042811109 0.78 18.5 18 5 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.50988221963741e-15 3.76940771674392e-14 1.24656880295978 0.777777777777778 18.5 18 5 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.73141657114131e-06 7.65157074762137e-06 1.24656880295978 0.777777777777778 18.5 18 5 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 3.61924525664502e-05 0.00013205605128733 1.24656880295978 0.777777777777778 18.5 18 5 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000795673168594118 0.00227358015845267 1.24656880295978 0.777777777777778 18.5 18 5 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000795673168594118 0.00227358015845267 1.24656880295978 0.777777777777778 18.5 18 5 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0196726480646866 0.0391526967776909 1.24656880295978 0.777777777777778 18.5 18 5 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0196726480646866 0.0391526967776909 1.24656880295978 0.777777777777778 18.5 18 5 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0196726480646866 0.0391526967776909 1.24656880295978 0.777777777777778 18.5 18 5 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0196726480646866 0.0391526967776909 1.24656880295978 0.777777777777778 18.5 18 5 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0196726480646866 0.0391526967776909 1.24656880295978 0.777777777777778 18.5 18 5 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.15810566794298e-10 1.96857972146337e-09 1.24656880295978 0.777777777777778 18.5 18 5 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.32487200349577e-18 5.09538611074184e-17 1.24509705702949 0.776859504132231 18.5 18 5 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.32487200349577e-18 5.09538611074184e-17 1.24509705702949 0.776859504132231 18.5 18 5 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.36794041920632e-09 9.44941367247864e-09 1.24349843645003 0.775862068965517 18.5 18 5 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.36794041920632e-09 9.44941367247864e-09 1.24349843645003 0.775862068965517 18.5 18 5 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.36794041920632e-09 9.44941367247864e-09 1.24349843645003 0.775862068965517 18.5 18 5 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.59450791335308e-16 4.63058114428865e-15 1.24324018132304 0.775700934579439 18.5 18 5 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.40304739734148e-19 6.65512148805644e-18 1.24242737836523 0.775193798449612 18.5 18 5 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.15176592835274e-12 1.88386542074248e-11 1.24211677152064 0.775 18.5 18 5 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 5.47369576907131e-07 2.66748941074948e-06 1.24211677152064 0.775 18.5 18 5 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 5.47369576907131e-07 2.66748941074948e-06 1.24211677152064 0.775 18.5 18 5 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.56117751767599e-61 9.11138901913234e-59 1.24155242950723 0.774647887323944 18.5 18 5 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.24312328102138e-11 2.34703266830399e-10 1.24155242950723 0.774647887323944 18.5 18 5 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.92514375737628e-14 4.2145839488407e-13 1.24082424626411 0.774193548387097 18.5 18 5 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 4.39499855188017e-10 3.22375409243581e-09 1.24082424626411 0.774193548387097 18.5 18 5 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.12736282846588e-05 4.4269131909211e-05 1.24082424626411 0.774193548387097 18.5 18 5 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.72567006210414e-13 6.62703562296775e-12 1.24020875804672 0.773809523809524 18.5 18 5 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.72567006210414e-13 6.62703562296775e-12 1.24020875804672 0.773809523809524 18.5 18 5 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 8.68322937760711e-09 5.39573598442573e-08 1.23984875550447 0.773584905660377 18.5 18 5 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000241034861630966 0.000762050337417444 1.23847420034316 0.772727272727273 18.5 18 5 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000241034861630966 0.000762050337417444 1.23847420034316 0.772727272727273 18.5 18 5 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.33660179244095e-12 3.46352536525362e-11 1.23755203042481 0.772151898734177 18.5 18 5 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 4.54921788587471e-11 4.59116102950334e-10 1.23639273109888 0.771428571428571 18.5 18 5 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 9.1393291976954e-25 6.84487655174766e-23 1.23504589805847 0.770588235294118 18.5 18 5 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.46534507807496e-11 1.60398926623128e-10 1.23453628555669 0.77027027027027 18.5 18 5 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.46534507807496e-11 1.60398926623128e-10 1.23453628555669 0.77027027027027 18.5 18 5 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.43836397786475e-13 4.69359053449525e-12 1.23428733692077 0.770114942528736 18.5 18 5 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.43836397786475e-13 4.69359053449525e-12 1.23428733692077 0.770114942528736 18.5 18 5 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 4.08876133445188e-15 9.84230868931008e-14 1.23410311493018 0.77 18.5 18 5 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.84538092528725e-24 1.31298852834188e-22 1.2328702446855 0.769230769230769 18.5 18 5 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 7.39774077288847e-05 0.00025738349926211 1.2328702446855 0.769230769230769 18.5 18 5 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 7.39774077288847e-05 0.00025738349926211 1.2328702446855 0.769230769230769 18.5 18 5 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 7.39774077288847e-05 0.00025738349926211 1.2328702446855 0.769230769230769 18.5 18 5 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 7.39774077288847e-05 0.00025738349926211 1.2328702446855 0.769230769230769 18.5 18 5 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00555682550023495 0.0127744146798616 1.2328702446855 0.769230769230769 18.5 18 5 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00555682550023495 0.0127744146798616 1.2328702446855 0.769230769230769 18.5 18 5 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00555682550023495 0.0127744146798616 1.2328702446855 0.769230769230769 18.5 18 5 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00555682550023495 0.0127744146798616 1.2328702446855 0.769230769230769 18.5 18 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00555682550023495 0.0127744146798616 1.2328702446855 0.769230769230769 18.5 18 5 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00555682550023495 0.0127744146798616 1.2328702446855 0.769230769230769 18.5 18 5 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.52334346853279e-12 2.28180816391807e-11 1.2313667443871 0.768292682926829 18.5 18 5 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 9.18875528079927e-11 9.01765432039818e-10 1.23108347621494 0.768115942028985 18.5 18 5 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.33960592568163e-41 8.82179890320709e-39 1.23076637054781 0.767918088737201 18.5 18 5 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 5.62048580123103e-09 3.60268076358187e-08 1.23066869067713 0.767857142857143 18.5 18 5 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.95518287797378e-11 3.04726466330195e-10 1.22949251798773 0.767123287671233 18.5 18 5 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.30681540828247e-23 1.42721666347216e-21 1.22908843411898 0.766871165644172 18.5 18 5 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.1845188675565e-29 1.40464195711076e-27 1.22876067720321 0.766666666666667 18.5 18 5 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 8.62734724573675e-16 2.19227055905061e-14 1.2282613839577 0.766355140186916 18.5 18 5 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 5.76115407647772e-10 4.18271543409582e-09 1.22709116541353 0.765625 18.5 18 5 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.06405397005691e-12 3.89298999945624e-11 1.22678199656359 0.765432098765432 18.5 18 5 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.06405397005691e-12 3.89298999945624e-11 1.22678199656359 0.765432098765432 18.5 18 5 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.27668088662109e-26 6.54317605647879e-24 1.2261332488129 0.765027322404372 18.5 18 5 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 9.8764836689679e-13 1.63638343599552e-11 1.22561806677558 0.764705882352941 18.5 18 5 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 7.15351775347678e-06 2.85939768629142e-05 1.22561806677558 0.764705882352941 18.5 18 5 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00163186095644561 0.00426863628864358 1.22561806677558 0.764705882352941 18.5 18 5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00163186095644561 0.00426863628864358 1.22561806677558 0.764705882352941 18.5 18 5 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00163186095644561 0.00426863628864358 1.22561806677558 0.764705882352941 18.5 18 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00163186095644561 0.00426863628864358 1.22561806677558 0.764705882352941 18.5 18 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00163186095644561 0.00426863628864358 1.22561806677558 0.764705882352941 18.5 18 5 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00163186095644561 0.00426863628864358 1.22561806677558 0.764705882352941 18.5 18 5 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00163186095644561 0.00426863628864358 1.22561806677558 0.764705882352941 18.5 18 5 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.92611312769326e-17 9.25301995712781e-16 1.22561806677558 0.764705882352941 18.5 18 5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 5.93599378157777e-11 5.86591607721192e-10 1.22430864576407 0.763888888888889 18.5 18 5 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 5.5978462059883e-16 1.50296889643799e-14 1.22390391563324 0.763636363636364 18.5 18 5 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.13069697388049e-08 6.81771946538956e-08 1.22390391563324 0.763636363636364 18.5 18 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.13069697388049e-08 6.81771946538956e-08 1.22390391563324 0.763636363636364 18.5 18 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.13069697388049e-08 6.81771946538956e-08 1.22390391563324 0.763636363636364 18.5 18 5 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.81078487876338e-16 5.15349376496059e-15 1.22313705854324 0.763157894736842 18.5 18 5 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.90836130458178e-11 2.01155417512583e-10 1.22313705854324 0.763157894736842 18.5 18 5 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 3.61121837210737e-09 2.3464674627894e-08 1.22242219176443 0.76271186440678 18.5 18 5 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.01932396651549e-35 1.6116644492795e-33 1.22200587088176 0.762452107279693 18.5 18 5 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.05368422241439e-30 1.36308422590516e-28 1.22181311244617 0.762331838565022 18.5 18 5 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.15530557804791e-09 8.09852136730138e-09 1.22112862330754 0.761904761904762 18.5 18 5 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 7.07841893217411e-07 3.40290207448775e-06 1.22112862330754 0.761904761904762 18.5 18 5 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.000490441489021992 0.00146309903328783 1.22112862330754 0.761904761904762 18.5 18 5 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000490441489021992 0.00146309903328783 1.22112862330754 0.761904761904762 18.5 18 5 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.9861389250174e-18 7.24686074435837e-17 1.22054154223864 0.761538461538461 18.5 18 5 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 2.23992462770831e-07 1.13028820752799e-06 1.21946948115631 0.760869565217391 18.5 18 5 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.23992462770831e-07 1.13028820752799e-06 1.21946948115631 0.760869565217391 18.5 18 5 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.18744595718793e-10 1.14171324126921e-09 1.21897874897073 0.76056338028169 18.5 18 5 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000149679077996694 0.000494184055659618 1.21807580174927 0.76 18.5 18 5 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000149679077996694 0.000494184055659618 1.21807580174927 0.76 18.5 18 5 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000149679077996694 0.000494184055659618 1.21807580174927 0.76 18.5 18 5 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.22598773274134e-11 1.37368546747317e-10 1.21726429222112 0.759493670886076 18.5 18 5 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.22598773274134e-11 1.37368546747317e-10 1.21726429222112 0.759493670886076 18.5 18 5 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.22598773274134e-11 1.37368546747317e-10 1.21726429222112 0.759493670886076 18.5 18 5 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.28167904254952e-18 5.09538611074184e-17 1.21711175283613 0.759398496240602 18.5 18 5 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.2626368335575e-08 1.31956238284931e-07 1.2168885933655 0.759259259259259 18.5 18 5 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.2626368335575e-08 1.31956238284931e-07 1.2168885933655 0.759259259259259 18.5 18 5 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 7.21635082359025e-09 4.54374655839333e-08 1.21586513786225 0.758620689655172 18.5 18 5 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 4.50283163135267e-08 2.50294117633393e-07 1.20960854195558 0.754716981132076 18.5 18 5 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.22742303500159e-29 4.6274022913902e-27 1.20933363092332 0.754545454545455 18.5 18 5 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.50440270981456e-10 1.4177252026928e-09 1.20753729445223 0.753424657534247 18.5 18 5 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.66979664198609e-66 7.92040207182068e-64 1.20357199742586 0.750950570342205 18.5 18 5 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.6660614861982e-21 2.65592219794401e-19 1.20204848856836 0.75 18.5 18 5 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.10486890522201e-14 2.45660695645455e-13 1.20204848856836 0.75 18.5 18 5 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.96898569427839e-10 2.211972064376e-09 1.20204848856836 0.75 18.5 18 5 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 2.89287608924834e-09 1.90581605324092e-08 1.20204848856836 0.75 18.5 18 5 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 2.80786810810447e-06 1.2107867629796e-05 1.20204848856836 0.75 18.5 18 5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 8.93744401596463e-06 3.5327730096438e-05 1.20204848856836 0.75 18.5 18 5 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000299519297688645 0.000920552830693178 1.20204848856836 0.75 18.5 18 5 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000299519297688645 0.000920552830693178 1.20204848856836 0.75 18.5 18 5 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000299519297688645 0.000920552830693178 1.20204848856836 0.75 18.5 18 5 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000985286481926163 0.00275454354377393 1.20204848856836 0.75 18.5 18 5 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000985286481926163 0.00275454354377393 1.20204848856836 0.75 18.5 18 5 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000985286481926163 0.00275454354377393 1.20204848856836 0.75 18.5 18 5 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000985286481926163 0.00275454354377393 1.20204848856836 0.75 18.5 18 5 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000985286481926163 0.00275454354377393 1.20204848856836 0.75 18.5 18 5 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000985286481926163 0.00275454354377393 1.20204848856836 0.75 18.5 18 5 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00329684442873617 0.00792467841569521 1.20204848856836 0.75 18.5 18 5 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00329684442873617 0.00792467841569521 1.20204848856836 0.75 18.5 18 5 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00329684442873617 0.00792467841569521 1.20204848856836 0.75 18.5 18 5 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0113239367515002 0.0236622055761892 1.20204848856836 0.75 18.5 18 5 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0113239367515002 0.0236622055761892 1.20204848856836 0.75 18.5 18 5 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0113239367515002 0.0236622055761892 1.20204848856836 0.75 18.5 18 5 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0113239367515002 0.0236622055761892 1.20204848856836 0.75 18.5 18 5 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0113239367515002 0.0236622055761892 1.20204848856836 0.75 18.5 18 5 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0113239367515002 0.0236622055761892 1.20204848856836 0.75 18.5 18 5 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0113239367515002 0.0236622055761892 1.20204848856836 0.75 18.5 18 5 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0406995276140592 0.0748261341018169 1.20204848856836 0.75 18.5 18 5 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0406995276140592 0.0748261341018169 1.20204848856836 0.75 18.5 18 5 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0406995276140592 0.0748261341018169 1.20204848856836 0.75 18.5 18 5 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0406995276140592 0.0748261341018169 1.20204848856836 0.75 18.5 18 5 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0406995276140592 0.0748261341018169 1.20204848856836 0.75 18.5 18 5 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0406995276140592 0.0748261341018169 1.20204848856836 0.75 18.5 18 5 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 4.1878880452919e-34 5.95936468845037e-32 1.19615609401655 0.746323529411765 18.5 18 5 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.81991919191709e-09 1.22736730336399e-08 1.19606814782921 0.746268656716418 18.5 18 5 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 5.57760356546878e-08 3.04096930025367e-07 1.1947633462134 0.745454545454545 18.5 18 5 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.57760356546878e-08 3.04096930025367e-07 1.1947633462134 0.745454545454545 18.5 18 5 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 5.57760356546878e-08 3.04096930025367e-07 1.1947633462134 0.745454545454545 18.5 18 5 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.75237963697872e-07 9.0349138529736e-07 1.19419196249929 0.745098039215686 18.5 18 5 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 1.74391034110588e-06 7.68292388666768e-06 1.19273028323062 0.744186046511628 18.5 18 5 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 5.52985249861199e-06 2.29416329607139e-05 1.19177456986265 0.743589743589744 18.5 18 5 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 5.64093937491021e-05 0.000202703452790334 1.18912323600311 0.741935483870968 18.5 18 5 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.21648033567858e-17 4.1215512325491e-16 1.18763543714668 0.741007194244604 18.5 18 5 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.09033881964816e-07 5.74648940873825e-07 1.18720838377122 0.740740740740741 18.5 18 5 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000181934422478697 0.000587710424880747 1.18720838377122 0.740740740740741 18.5 18 5 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000181934422478697 0.000587710424880747 1.18720838377122 0.740740740740741 18.5 18 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000181934422478697 0.000587710424880747 1.18720838377122 0.740740740740741 18.5 18 5 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.61326893974528e-13 3.27954528751077e-12 1.18663761050979 0.740384615384615 18.5 18 5 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000592189466365594 0.0017208658453817 1.18462749598041 0.739130434782609 18.5 18 5 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 3.40753205328486e-06 1.45613156511242e-05 1.18296835382918 0.738095238095238 18.5 18 5 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00195171647267634 0.00501758937351376 1.18095991859348 0.736842105263158 18.5 18 5 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.38239981305263e-09 9.45747564410527e-09 1.17978833137265 0.736111111111111 18.5 18 5 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.38239981305263e-09 9.45747564410527e-09 1.17978833137265 0.736111111111111 18.5 18 5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.4401751712191e-05 0.000127152448536228 1.17847891036114 0.735294117647059 18.5 18 5 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 3.4401751712191e-05 0.000127152448536228 1.17847891036114 0.735294117647059 18.5 18 5 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 3.4401751712191e-05 0.000127152448536228 1.17847891036114 0.735294117647059 18.5 18 5 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 3.4401751712191e-05 0.000127152448536228 1.17847891036114 0.735294117647059 18.5 18 5 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 3.4401751712191e-05 0.000127152448536228 1.17847891036114 0.735294117647059 18.5 18 5 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 6.65112166202257e-07 3.20832072035868e-06 1.17751688676084 0.73469387755102 18.5 18 5 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.34069331257013e-08 8.01599404952645e-08 1.17700581172319 0.734375 18.5 18 5 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000110151538101847 0.000371435162841063 1.17533629993351 0.733333333333333 18.5 18 5 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00654818395755602 0.0146270746854145 1.17533629993351 0.733333333333333 18.5 18 5 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00654818395755602 0.0146270746854145 1.17533629993351 0.733333333333333 18.5 18 5 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00654818395755602 0.0146270746854145 1.17533629993351 0.733333333333333 18.5 18 5 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00654818395755602 0.0146270746854145 1.17533629993351 0.733333333333333 18.5 18 5 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00654818395755602 0.0146270746854145 1.17533629993351 0.733333333333333 18.5 18 5 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 6.60686221618987e-06 2.64832815032062e-05 1.17273023274962 0.731707317073171 18.5 18 5 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 6.60686221618987e-06 2.64832815032062e-05 1.17273023274962 0.731707317073171 18.5 18 5 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 6.60686221618987e-06 2.64832815032062e-05 1.17273023274962 0.731707317073171 18.5 18 5 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 6.60686221618987e-06 2.64832815032062e-05 1.17273023274962 0.731707317073171 18.5 18 5 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 5.32009704415969e-10 3.88230671478935e-09 1.17122673245122 0.730769230769231 18.5 18 5 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000355155040152176 0.00108451850243894 1.17122673245122 0.730769230769231 18.5 18 5 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000355155040152176 0.00108451850243894 1.17122673245122 0.730769230769231 18.5 18 5 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.09259490768552e-05 7.94070014303065e-05 1.16956069158003 0.72972972972973 18.5 18 5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.09259490768552e-05 7.94070014303065e-05 1.16956069158003 0.72972972972973 18.5 18 5 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 8.78562283726097e-19 3.78846705982496e-17 1.16928825722373 0.729559748427673 18.5 18 5 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 1.28275222745931e-06 5.75822214408392e-06 1.16865825277479 0.729166666666667 18.5 18 5 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.27399668313326e-12 5.33499761412161e-11 1.16562277679356 0.727272727272727 18.5 18 5 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00115552582873139 0.00318665359357514 1.16562277679356 0.727272727272727 18.5 18 5 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00115552582873139 0.00318665359357514 1.16562277679356 0.727272727272727 18.5 18 5 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00115552582873139 0.00318665359357514 1.16562277679356 0.727272727272727 18.5 18 5 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00115552582873139 0.00318665359357514 1.16562277679356 0.727272727272727 18.5 18 5 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0225845468823679 0.0437844825798494 1.16562277679356 0.727272727272727 18.5 18 5 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 6.65585978764481e-05 0.000235019565206416 1.16562277679356 0.727272727272727 18.5 18 5 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 6.65585978764481e-05 0.000235019565206416 1.16562277679356 0.727272727272727 18.5 18 5 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 6.65585978764481e-05 0.000235019565206416 1.16562277679356 0.727272727272727 18.5 18 5 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.31804384940557e-11 1.46529406070635e-10 1.16408906261357 0.726315789473684 18.5 18 5 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.20294988353334e-18 1.13944942106699e-16 1.16376668956937 0.726114649681529 18.5 18 5 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 4.94353412163946e-08 2.72660816088874e-07 1.16327273087261 0.725806451612903 18.5 18 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.84606668677327e-07 3.70928667617221e-06 1.16276585822299 0.725490196078431 18.5 18 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.84606668677327e-07 3.70928667617221e-06 1.16276585822299 0.725490196078431 18.5 18 5 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 1.27059931644955e-05 4.92660170928531e-05 1.16198020561608 0.725 18.5 18 5 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 2.45632773231515e-06 1.06891570736528e-05 1.1594226556404 0.723404255319149 18.5 18 5 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.45632773231515e-06 1.06891570736528e-05 1.1594226556404 0.723404255319149 18.5 18 5 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0038059492048595 0.00907180187355959 1.15752817417694 0.722222222222222 18.5 18 5 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0038059492048595 0.00907180187355959 1.15752817417694 0.722222222222222 18.5 18 5 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0038059492048595 0.00907180187355959 1.15752817417694 0.722222222222222 18.5 18 5 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.49464607164821e-06 6.66733968638059e-06 1.15396654902563 0.72 18.5 18 5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.49464607164821e-06 6.66733968638059e-06 1.15396654902563 0.72 18.5 18 5 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.000684822719753663 0.00197267759151713 1.15396654902563 0.72 18.5 18 5 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000684822719753663 0.00197267759151713 1.15396654902563 0.72 18.5 18 5 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 7.33078792275835e-10 5.26854101721472e-09 1.15318472887046 0.719512195121951 18.5 18 5 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.78147669632384e-07 9.15177378653006e-07 1.14862411129865 0.716666666666667 18.5 18 5 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.51264989283983e-08 2.0236845334053e-07 1.14822542191605 0.716417910447761 18.5 18 5 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.76909193394679e-27 1.48083401294487e-25 1.14656932755751 0.715384615384615 18.5 18 5 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 2.82685238060194e-06 1.21529031347328e-05 1.14480808435082 0.714285714285714 18.5 18 5 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 7.63735998452615e-05 0.000261878632722427 1.14480808435082 0.714285714285714 18.5 18 5 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 7.63735998452615e-05 0.000261878632722427 1.14480808435082 0.714285714285714 18.5 18 5 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 7.63735998452615e-05 0.000261878632722427 1.14480808435082 0.714285714285714 18.5 18 5 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00222239896418659 0.00562717744846533 1.14480808435082 0.714285714285714 18.5 18 5 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00222239896418659 0.00562717744846533 1.14480808435082 0.714285714285714 18.5 18 5 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00222239896418659 0.00562717744846533 1.14480808435082 0.714285714285714 18.5 18 5 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00222239896418659 0.00562717744846533 1.14480808435082 0.714285714285714 18.5 18 5 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000406403369411864 0.0012357093903271 1.14480808435082 0.714285714285714 18.5 18 5 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0127559357640173 0.0263832799305184 1.14480808435082 0.714285714285714 18.5 18 5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0127559357640173 0.0263832799305184 1.14480808435082 0.714285714285714 18.5 18 5 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0127559357640173 0.0263832799305184 1.14480808435082 0.714285714285714 18.5 18 5 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0127559357640173 0.0263832799305184 1.14480808435082 0.714285714285714 18.5 18 5 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0127559357640173 0.0263832799305184 1.14480808435082 0.714285714285714 18.5 18 5 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0127559357640173 0.0263832799305184 1.14480808435082 0.714285714285714 18.5 18 5 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0817510845330393 0.132950620903446 1.14480808435082 0.714285714285714 18.5 18 5 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0817510845330393 0.132950620903446 1.14480808435082 0.714285714285714 18.5 18 5 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0817510845330393 0.132950620903446 1.14480808435082 0.714285714285714 18.5 18 5 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0817510845330393 0.132950620903446 1.14480808435082 0.714285714285714 18.5 18 5 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0817510845330393 0.132950620903446 1.14480808435082 0.714285714285714 18.5 18 5 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0817510845330393 0.132950620903446 1.14480808435082 0.714285714285714 18.5 18 5 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0817510845330393 0.132950620903446 1.14480808435082 0.714285714285714 18.5 18 5 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0817510845330393 0.132950620903446 1.14480808435082 0.714285714285714 18.5 18 5 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 4.14995447195084e-15 9.84230868931008e-14 1.14151367259729 0.712230215827338 18.5 18 5 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.48118509109938e-19 3.77147699519826e-17 1.14092737898014 0.711864406779661 18.5 18 5 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.35104987085276e-07 1.67906477683925e-06 1.14092737898014 0.711864406779661 18.5 18 5 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.71097614712247e-06 7.60849705423525e-06 1.14040497633408 0.711538461538462 18.5 18 5 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 8.80358752956823e-06 3.48955572550852e-05 1.13972004842037 0.711111111111111 18.5 18 5 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.14522166386099e-16 8.77578515230234e-15 1.13878277864371 0.710526315789474 18.5 18 5 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 7.9625243192571e-09 4.9695930290802e-08 1.13878277864371 0.710526315789474 18.5 18 5 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000241521224297447 0.000762050337417444 1.1374222257421 0.709677419354839 18.5 18 5 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 9.86290619565002e-22 5.84788146517082e-20 1.13717603045515 0.70952380952381 18.5 18 5 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 5.30643967267929e-06 2.20791334918791e-05 1.13526801698123 0.708333333333333 18.5 18 5 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 5.30643967267929e-06 2.20791334918791e-05 1.13526801698123 0.708333333333333 18.5 18 5 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00130295987600961 0.00349173616489959 1.13526801698123 0.708333333333333 18.5 18 5 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00130295987600961 0.00349173616489959 1.13526801698123 0.708333333333333 18.5 18 5 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.23371731832919e-07 6.47815403683554e-07 1.13424062511066 0.707692307692308 18.5 18 5 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.55445526591738e-13 6.48460236333388e-12 1.1336392249913 0.707317073170732 18.5 18 5 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 8.79528656721543e-12 1.00933006331835e-10 1.1322046925965 0.706422018348624 18.5 18 5 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.79690475796698e-09 1.21761689075572e-08 1.13133975394669 0.705882352941177 18.5 18 5 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.79690475796698e-09 1.21761689075572e-08 1.13133975394669 0.705882352941177 18.5 18 5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 7.48252189437689e-08 4.00286791567606e-07 1.13133975394669 0.705882352941177 18.5 18 5 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00729280476223349 0.0162150955885285 1.13133975394669 0.705882352941177 18.5 18 5 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00729280476223349 0.0162150955885285 1.13133975394669 0.705882352941177 18.5 18 5 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.252151786434e-18 5.09538611074184e-17 1.12979420783474 0.704918032786885 18.5 18 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.09324180157678e-09 7.70140140417705e-09 1.12919706501876 0.704545454545455 18.5 18 5 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 8.10259534043613e-14 1.72089450290158e-12 1.12919706501876 0.704545454545455 18.5 18 5 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 5.47679461576271e-09 3.52646096752504e-08 1.12784796458266 0.703703703703704 18.5 18 5 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000766554007126691 0.00219920635512355 1.12784796458266 0.703703703703704 18.5 18 5 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000766554007126691 0.00219920635512355 1.12784796458266 0.703703703703704 18.5 18 5 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.51294969101852e-16 1.97980137228136e-14 1.1270820236899 0.703225806451613 18.5 18 5 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 4.58672478843495e-16 1.25517487960441e-14 1.12596947030454 0.70253164556962 18.5 18 5 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 7.41794918686861e-13 1.27177610758e-11 1.12449697317685 0.701612903225806 18.5 18 5 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 7.41794918686861e-13 1.27177610758e-11 1.12449697317685 0.701612903225806 18.5 18 5 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 7.41794918686861e-13 1.27177610758e-11 1.12449697317685 0.701612903225806 18.5 18 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.01971368953201e-09 1.35568517934153e-08 1.12375414256965 0.701149425287356 18.5 18 5 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.38869805229626e-14 7.30623837639027e-13 1.1219119226638 0.7 18.5 18 5 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 5.11063829750909e-05 0.000184579652217143 1.1219119226638 0.7 18.5 18 5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.000452320457176132 0.0013694723628971 1.1219119226638 0.7 18.5 18 5 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000452320457176132 0.0013694723628971 1.1219119226638 0.7 18.5 18 5 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00420671978442674 0.00996033652785233 1.1219119226638 0.7 18.5 18 5 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.043904243532995 0.0789832345732642 1.1219119226638 0.7 18.5 18 5 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.043904243532995 0.0789832345732642 1.1219119226638 0.7 18.5 18 5 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.043904243532995 0.0789832345732642 1.1219119226638 0.7 18.5 18 5 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.043904243532995 0.0789832345732642 1.1219119226638 0.7 18.5 18 5 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.043904243532995 0.0789832345732642 1.1219119226638 0.7 18.5 18 5 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.043904243532995 0.0789832345732642 1.1219119226638 0.7 18.5 18 5 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.043904243532995 0.0789832345732642 1.1219119226638 0.7 18.5 18 5 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.043904243532995 0.0789832345732642 1.1219119226638 0.7 18.5 18 5 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.36401795493645e-12 2.06489101050486e-11 1.12060888907186 0.699186991869919 18.5 18 5 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.25663019383233e-82 4.6341847658234e-79 1.12046148708182 0.699095022624434 18.5 18 5 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 6.12740057042331e-09 3.90999596937775e-08 1.11998092107574 0.698795180722892 18.5 18 5 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 3.05281864243102e-05 0.000114621660374125 1.11818464052871 0.697674418604651 18.5 18 5 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000267587451619192 0.00084056720453446 1.11705516109383 0.696969696969697 18.5 18 5 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000267587451619192 0.00084056720453446 1.11705516109383 0.696969696969697 18.5 18 5 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.54066762254675e-07 8.03065943913565e-07 1.11494352562862 0.695652173913043 18.5 18 5 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 5.94722016086568e-18 2.06412055827118e-16 1.11419824252326 0.695187165775401 18.5 18 5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.91851100520997e-15 4.70696751795481e-14 1.11189485192573 0.69375 18.5 18 5 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.25963861371667e-13 2.5977764453896e-12 1.11046384182029 0.692857142857143 18.5 18 5 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.001426574998857 0.00380866083184524 1.10958322021695 0.692307692307692 18.5 18 5 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.001426574998857 0.00380866083184524 1.10958322021695 0.692307692307692 18.5 18 5 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0242999370668472 0.046665061330801 1.10958322021695 0.692307692307692 18.5 18 5 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0242999370668472 0.046665061330801 1.10958322021695 0.692307692307692 18.5 18 5 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0242999370668472 0.046665061330801 1.10958322021695 0.692307692307692 18.5 18 5 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0242999370668472 0.046665061330801 1.10958322021695 0.692307692307692 18.5 18 5 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 5.6089466390901e-05 0.000202064077656334 1.10664781487246 0.69047619047619 18.5 18 5 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 3.57485614916382e-17 1.10587397831742e-15 1.10623302933465 0.690217391304348 18.5 18 5 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.22520552663303e-10 1.17011239221396e-09 1.10279677850308 0.688073394495413 18.5 18 5 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000492419766595148 0.0014659274641525 1.10187778118766 0.6875 18.5 18 5 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0137011309209597 0.0281744354053839 1.10187778118766 0.6875 18.5 18 5 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0137011309209597 0.0281744354053839 1.10187778118766 0.6875 18.5 18 5 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.19216312386846e-05 4.6351041673902e-05 1.09991364967039 0.686274509803922 18.5 18 5 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.35324086271099e-08 8.05716212400729e-08 1.09954822985323 0.686046511627907 18.5 18 5 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 6.04647197273805e-12 7.41735311828125e-11 1.09793405255063 0.68503937007874 18.5 18 5 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.33743618740101e-10 1.26878112978109e-09 1.09736558716151 0.684684684684685 18.5 18 5 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00782345345792304 0.0173407698919384 1.09660563869394 0.684210526315789 18.5 18 5 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 2.4013318375446e-10 2.02194982534081e-09 1.09277135324396 0.681818181818182 18.5 18 5 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00261650133305352 0.00657823568363103 1.08985729630198 0.68 18.5 18 5 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00261650133305352 0.00657823568363103 1.08985729630198 0.68 18.5 18 5 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00152687202008021 0.00406119417677408 1.08756768013328 0.678571428571429 18.5 18 5 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 6.58912151701969e-19 3.02461932861904e-17 1.08525752929042 0.677130044843049 18.5 18 5 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000526551608693385 0.00154491327664059 1.08420059753225 0.676470588235294 18.5 18 5 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000526551608693385 0.00154491327664059 1.08420059753225 0.676470588235294 18.5 18 5 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000310742004802603 0.000952986794901088 1.0829265662778 0.675675675675676 18.5 18 5 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 7.77319904076067e-21 3.95045079821516e-19 1.08120763522022 0.674603174603175 18.5 18 5 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 7.77319904076067e-21 3.95045079821516e-19 1.08120763522022 0.674603174603175 18.5 18 5 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 7.77319904076067e-21 3.95045079821516e-19 1.08120763522022 0.674603174603175 18.5 18 5 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.67964868652113e-08 2.59110508985197e-07 1.08091181917775 0.674418604651163 18.5 18 5 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000109037832035982 0.000368553052226134 1.08091181917775 0.674418604651163 18.5 18 5 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 6.47898270702107e-05 0.000230489809802275 1.08010154045273 0.673913043478261 18.5 18 5 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 6.47898270702107e-05 0.000230489809802275 1.08010154045273 0.673913043478261 18.5 18 5 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 3.00965753132649e-12 3.89298999945624e-11 1.07985443417489 0.673758865248227 18.5 18 5 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.02370927043901e-08 6.30622637157881e-08 1.07973478271404 0.673684210526316 18.5 18 5 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.02370927043901e-08 6.30622637157881e-08 1.07973478271404 0.673684210526316 18.5 18 5 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.44079901301932e-13 4.69359053449525e-12 1.07876146409981 0.673076923076923 18.5 18 5 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.16016916812016e-10 1.12307532396938e-09 1.07279596291585 0.669354838709677 18.5 18 5 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00160524356446822 0.00425374598182175 1.0684875453941 0.666666666666667 18.5 18 5 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00274661698231763 0.00682100517598253 1.0684875453941 0.666666666666667 18.5 18 5 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00274661698231763 0.00682100517598253 1.0684875453941 0.666666666666667 18.5 18 5 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00274661698231763 0.00682100517598253 1.0684875453941 0.666666666666667 18.5 18 5 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0251714393769399 0.0482085575146508 1.0684875453941 0.666666666666667 18.5 18 5 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0251714393769399 0.0482085575146508 1.0684875453941 0.666666666666667 18.5 18 5 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0827532867128045 0.133361185721768 1.0684875453941 0.666666666666667 18.5 18 5 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0827532867128045 0.133361185721768 1.0684875453941 0.666666666666667 18.5 18 5 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0827532867128045 0.133361185721768 1.0684875453941 0.666666666666667 18.5 18 5 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0827532867128045 0.133361185721768 1.0684875453941 0.666666666666667 18.5 18 5 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0827532867128045 0.133361185721768 1.0684875453941 0.666666666666667 18.5 18 5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0827532867128045 0.133361185721768 1.0684875453941 0.666666666666667 18.5 18 5 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0827532867128045 0.133361185721768 1.0684875453941 0.666666666666667 18.5 18 5 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0827532867128045 0.133361185721768 1.0684875453941 0.666666666666667 18.5 18 5 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 2.42603754320679e-07 1.21987682826264e-06 1.0684875453941 0.666666666666667 18.5 18 5 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000942084396547063 0.00267049023164636 1.0684875453941 0.666666666666667 18.5 18 5 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0451057671441032 0.0796346236303459 1.0684875453941 0.666666666666667 18.5 18 5 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0451057671441032 0.0796346236303459 1.0684875453941 0.666666666666667 18.5 18 5 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0451057671441032 0.0796346236303459 1.0684875453941 0.666666666666667 18.5 18 5 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 7.15248683164583e-40 1.272248595179e-37 1.06548617588456 0.664794007490637 18.5 18 5 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.67935874195368e-09 1.78164835971966e-08 1.06363078382412 0.663636363636364 18.5 18 5 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 7.35951859547125e-09 4.61347795654431e-08 1.06335058604124 0.663461538461538 18.5 18 5 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 9.25512764976634e-08 4.8959281210474e-07 1.06248480637503 0.662921348314607 18.5 18 5 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 6.20431598297144e-10 4.48159474302962e-09 1.05965706981233 0.661157024793388 18.5 18 5 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.81670798641848e-09 1.86426765798767e-08 1.05894747802451 0.660714285714286 18.5 18 5 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.71612053110391e-27 1.48083401294487e-25 1.05848833039709 0.660427807486631 18.5 18 5 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000202561347658086 0.000652137551396961 1.05634564146916 0.659090909090909 18.5 18 5 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 9.8895977157846e-13 1.63638343599552e-11 1.05545720947466 0.658536585365854 18.5 18 5 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.23085782157488e-06 5.56035136540015e-06 1.05442849874417 0.657894736842105 18.5 18 5 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000577430539646212 0.00168723543720033 1.05442849874417 0.657894736842105 18.5 18 5 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000577430539646212 0.00168723543720033 1.05442849874417 0.657894736842105 18.5 18 5 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00097859013925493 0.00275454354377393 1.05322343760275 0.657142857142857 18.5 18 5 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.67549900084531e-23 1.08374321736495e-21 1.05209969960584 0.656441717791411 18.5 18 5 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 1.58576407926633e-05 6.11529074470457e-05 1.05097135612534 0.655737704918033 18.5 18 5 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.96223040254682e-54 8.43050772564825e-52 1.05070222133504 0.655569782330346 18.5 18 5 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 7.70008459237775e-07 3.68710974397063e-06 1.04870073899791 0.654320987654321 18.5 18 5 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0048641399643136 0.0113099202111409 1.04793970798267 0.653846153846154 18.5 18 5 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0048641399643136 0.0113099202111409 1.04793970798267 0.653846153846154 18.5 18 5 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0048641399643136 0.0113099202111409 1.04793970798267 0.653846153846154 18.5 18 5 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.7451004410308e-07 9.03010155486122e-07 1.04525955527683 0.652173913043478 18.5 18 5 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00838118796395523 0.0179754054867357 1.04525955527683 0.652173913043478 18.5 18 5 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00838118796395523 0.0179754054867357 1.04525955527683 0.652173913043478 18.5 18 5 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 7.97511500551949e-07 3.75781081220339e-06 1.04274085755328 0.650602409638554 18.5 18 5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0145402445658448 0.0295582400245673 1.04177535675925 0.65 18.5 18 5 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0145402445658448 0.0295582400245673 1.04177535675925 0.65 18.5 18 5 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0145402445658448 0.0295582400245673 1.04177535675925 0.65 18.5 18 5 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.95771036765002e-07 2.43269719074689e-06 1.03813278558177 0.647727272727273 18.5 18 5 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 8.22233256115608e-07 3.81119844772805e-06 1.0370614411178 0.647058823529412 18.5 18 5 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 8.22233256115608e-07 3.81119844772805e-06 1.0370614411178 0.647058823529412 18.5 18 5 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 8.22233256115608e-07 3.81119844772805e-06 1.0370614411178 0.647058823529412 18.5 18 5 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 8.22233256115608e-07 3.81119844772805e-06 1.0370614411178 0.647058823529412 18.5 18 5 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 8.22233256115608e-07 3.81119844772805e-06 1.0370614411178 0.647058823529412 18.5 18 5 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0254497288786245 0.0486106901936681 1.0370614411178 0.647058823529412 18.5 18 5 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0254497288786245 0.0486106901936681 1.0370614411178 0.647058823529412 18.5 18 5 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000214985625830535 0.0006828672891894 1.03509730960053 0.645833333333333 18.5 18 5 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.81284481907857e-05 0.000105890957078011 1.03402020522009 0.645161290322581 18.5 18 5 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.04366981944978e-10 2.25580320472763e-09 1.03112784100969 0.643356643356643 18.5 18 5 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 1.03813607713749e-05 4.09215412123724e-05 1.03032727591574 0.642857142857143 18.5 18 5 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000607277349655802 0.00175641396048822 1.03032727591574 0.642857142857143 18.5 18 5 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0450791394119409 0.0796346236303459 1.03032727591574 0.642857142857143 18.5 18 5 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0450791394119409 0.0796346236303459 1.03032727591574 0.642857142857143 18.5 18 5 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0450791394119409 0.0796346236303459 1.03032727591574 0.642857142857143 18.5 18 5 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0450791394119409 0.0796346236303459 1.03032727591574 0.642857142857143 18.5 18 5 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0450791394119409 0.0796346236303459 1.03032727591574 0.642857142857143 18.5 18 5 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0450791394119409 0.0796346236303459 1.03032727591574 0.642857142857143 18.5 18 5 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0450791394119409 0.0796346236303459 1.03032727591574 0.642857142857143 18.5 18 5 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0450791394119409 0.0796346236303459 1.03032727591574 0.642857142857143 18.5 18 5 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00172836398335964 0.00450450906285854 1.02396723100268 0.638888888888889 18.5 18 5 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000132901718694185 0.000442901980566335 1.01991992969437 0.636363636363636 18.5 18 5 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.000132901718694185 0.000442901980566335 1.01991992969437 0.636363636363636 18.5 18 5 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0145922714732108 0.0295794904649274 1.01991992969437 0.636363636363636 18.5 18 5 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0145922714732108 0.0295794904649274 1.01991992969437 0.636363636363636 18.5 18 5 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0812137126715925 0.132950620903446 1.01991992969437 0.636363636363636 18.5 18 5 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0812137126715925 0.132950620903446 1.01991992969437 0.636363636363636 18.5 18 5 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0812137126715925 0.132950620903446 1.01991992969437 0.636363636363636 18.5 18 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0812137126715925 0.132950620903446 1.01991992969437 0.636363636363636 18.5 18 5 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0812137126715925 0.132950620903446 1.01991992969437 0.636363636363636 18.5 18 5 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.95524821191071e-17 6.47050745476496e-16 1.01834192052001 0.635379061371841 18.5 18 5 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0010336066659048 0.00287832149820457 1.01636620171634 0.634146341463415 18.5 18 5 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.0010336066659048 0.00287832149820457 1.01636620171634 0.634146341463415 18.5 18 5 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 6.43515562469289e-09 4.06987842397244e-08 1.01547098779821 0.633587786259542 18.5 18 5 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 6.43515562469289e-09 4.06987842397244e-08 1.01547098779821 0.633587786259542 18.5 18 5 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.18854185256107e-13 4.38633106506254e-12 1.01506316812439 0.633333333333333 18.5 18 5 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 6.57174648718052e-06 2.64832815032062e-05 1.01438691018427 0.632911392405063 18.5 18 5 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 4.24031770209359e-12 5.33499761412161e-11 1.01005463275536 0.630208333333333 18.5 18 5 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00846392903370674 0.0180843408633103 1.00912712620554 0.62962962962963 18.5 18 5 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.39631647610437e-07 1.69577485806896e-06 1.00743111422872 0.628571428571429 18.5 18 5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00293133266944741 0.0071426136791501 1.00743111422872 0.628571428571429 18.5 18 5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.41819118549934e-07 1.7007293905474e-06 1.00357942347763 0.626168224299065 18.5 18 5 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0144772751579799 0.0295569046625616 1.00170707380697 0.625 18.5 18 5 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0144772751579799 0.0295569046625616 1.00170707380697 0.625 18.5 18 5 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0144772751579799 0.0295569046625616 1.00170707380697 0.625 18.5 18 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0442886201369069 0.0792738445972561 1.00170707380697 0.625 18.5 18 5 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0442886201369069 0.0792738445972561 1.00170707380697 0.625 18.5 18 5 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0442886201369069 0.0792738445972561 1.00170707380697 0.625 18.5 18 5 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0442886201369069 0.0792738445972561 1.00170707380697 0.625 18.5 18 5 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.150170346064673 0.223761677958146 1.00170707380697 0.625 18.5 18 5 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.150170346064673 0.223761677958146 1.00170707380697 0.625 18.5 18 5 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.150170346064673 0.223761677958146 1.00170707380697 0.625 18.5 18 5 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.150170346064673 0.223761677958146 1.00170707380697 0.625 18.5 18 5 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.150170346064673 0.223761677958146 1.00170707380697 0.625 18.5 18 5 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.150170346064673 0.223761677958146 1.00170707380697 0.625 18.5 18 5 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.150170346064673 0.223761677958146 1.00170707380697 0.625 18.5 18 5 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.150170346064673 0.223761677958146 1.00170707380697 0.625 18.5 18 5 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00838477664785196 0.0179754054867357 0.994798749160022 0.620689655172414 18.5 18 5 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00838477664785196 0.0179754054867357 0.994798749160022 0.620689655172414 18.5 18 5 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.05805111296718e-80 7.5280336687615e-78 0.990196172636041 0.617817947062621 18.5 18 5 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00490053473696719 0.0113759558412795 0.989922284703355 0.617647058823529 18.5 18 5 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0142377495721096 0.0291935412696138 0.986296195748398 0.615384615384615 18.5 18 5 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0783950952677128 0.129415569102036 0.986296195748398 0.615384615384615 18.5 18 5 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0783950952677128 0.129415569102036 0.986296195748398 0.615384615384615 18.5 18 5 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.08086747375326e-07 1.0575265768396e-06 0.985285646367508 0.614754098360656 18.5 18 5 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 8.0448114105887e-05 0.000275186698011243 0.984534952541704 0.614285714285714 18.5 18 5 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00824829183902733 0.0179754054867357 0.98231919495909 0.612903225806452 18.5 18 5 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.8223884838889e-28 1.85232772326708e-26 0.979602854665167 0.611208406304729 18.5 18 5 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00482171203329961 0.0112850266831996 0.979446916611256 0.611111111111111 18.5 18 5 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0430233493097778 0.0784900334202741 0.979446916611256 0.611111111111111 18.5 18 5 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0430233493097778 0.0784900334202741 0.979446916611256 0.611111111111111 18.5 18 5 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0430233493097778 0.0784900334202741 0.979446916611256 0.611111111111111 18.5 18 5 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.95765691382985e-06 1.66619697881061e-05 0.977666104035599 0.61 18.5 18 5 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0028380219831087 0.00693901251196508 0.977275193958016 0.609756097560976 18.5 18 5 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00167946671812714 0.0043851030089815 0.975575584925045 0.608695652173913 18.5 18 5 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0139066662181748 0.0285558239948958 0.973086871698196 0.607142857142857 18.5 18 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000213654979974544 0.000680158918352967 0.971352313994634 0.606060606060606 18.5 18 5 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.29270052729399e-23 8.75958500161593e-22 0.970760025998296 0.605691056910569 18.5 18 5 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0047210123899148 0.0110675463440672 0.970074218844641 0.605263157894737 18.5 18 5 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 4.66548833369124e-05 0.000169361987215373 0.969553513413162 0.604938271604938 18.5 18 5 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.4286753819688e-45 3.38834178090268e-43 0.965810063554424 0.602602602602603 18.5 18 5 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0135096098571992 0.0278611229373832 0.961638790854688 0.6 18.5 18 5 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 4.202917581167e-08 2.37331417380978e-07 0.961638790854688 0.6 18.5 18 5 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00785433783824686 0.01738215045696 0.961638790854688 0.6 18.5 18 5 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.023489126251674 0.0453528177152404 0.961638790854688 0.6 18.5 18 5 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.023489126251674 0.0453528177152404 0.961638790854688 0.6 18.5 18 5 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.023489126251674 0.0453528177152404 0.961638790854688 0.6 18.5 18 5 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0414690474967942 0.0760444002421883 0.961638790854688 0.6 18.5 18 5 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0414690474967942 0.0760444002421883 0.961638790854688 0.6 18.5 18 5 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.141026851482519 0.218369107355413 0.961638790854688 0.6 18.5 18 5 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.141026851482519 0.218369107355413 0.961638790854688 0.6 18.5 18 5 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.141026851482519 0.218369107355413 0.961638790854688 0.6 18.5 18 5 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.141026851482519 0.218369107355413 0.961638790854688 0.6 18.5 18 5 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.141026851482519 0.218369107355413 0.961638790854688 0.6 18.5 18 5 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.141026851482519 0.218369107355413 0.961638790854688 0.6 18.5 18 5 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.141026851482519 0.218369107355413 0.961638790854688 0.6 18.5 18 5 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.141026851482519 0.218369107355413 0.961638790854688 0.6 18.5 18 5 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.12388852934189e-08 2.3473173509014e-07 0.959597094908075 0.598726114649682 18.5 18 5 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00156770555722881 0.00416202426853842 0.95547443963126 0.596153846153846 18.5 18 5 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.5033373394047e-27 1.42616602264859e-25 0.95216697280065 0.594090202177294 18.5 18 5 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0130664430230937 0.0269862821797711 0.951621720116618 0.59375 18.5 18 5 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00256366434147279 0.00646825240765209 0.948555269890678 0.591836734693878 18.5 18 5 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00736172613507263 0.016342802324818 0.945200520925548 0.58974358974359 18.5 18 5 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0712013219344533 0.120189182814623 0.94278312828891 0.588235294117647 18.5 18 5 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0712013219344533 0.120189182814623 0.94278312828891 0.588235294117647 18.5 18 5 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00418611323724557 0.00992806522766741 0.940733599749151 0.58695652173913 18.5 18 5 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0023970653385177 0.00605865715223924 0.937446620015576 0.584905660377358 18.5 18 5 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000826566306197628 0.00235712195134113 0.936981385960978 0.584615384615385 18.5 18 5 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.05054544171352e-08 6.41599211827615e-08 0.935604576550669 0.583756345177665 18.5 18 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00403520470436241 0.00958613738615645 0.934926602219835 0.583333333333333 18.5 18 5 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.131764836410077 0.206045452979714 0.934926602219835 0.583333333333333 18.5 18 5 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.131764836410077 0.206045452979714 0.934926602219835 0.583333333333333 18.5 18 5 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0673767767206636 0.114275510457097 0.927897078894874 0.578947368421053 18.5 18 5 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00654676408507511 0.0146270746854145 0.926022539341551 0.577777777777778 18.5 18 5 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0361046399056256 0.0670366591775332 0.924652683514123 0.576923076923077 18.5 18 5 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0011340839129407 0.00315195587522386 0.915846467480655 0.571428571428571 18.5 18 5 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.010592551788255 0.0223970300069641 0.915846467480655 0.571428571428571 18.5 18 5 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0342751910228444 0.0640073449153643 0.915846467480655 0.571428571428571 18.5 18 5 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.122816369742075 0.192900324661118 0.915846467480655 0.571428571428571 18.5 18 5 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.122816369742075 0.192900324661118 0.915846467480655 0.571428571428571 18.5 18 5 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.122816369742075 0.192900324661118 0.915846467480655 0.571428571428571 18.5 18 5 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.122816369742075 0.192900324661118 0.915846467480655 0.571428571428571 18.5 18 5 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00327320538725026 0.00790793084220225 0.911898853396687 0.568965517241379 18.5 18 5 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00327320538725026 0.00790793084220225 0.911898853396687 0.568965517241379 18.5 18 5 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00327320538725026 0.00790793084220225 0.911898853396687 0.568965517241379 18.5 18 5 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 2.37362807008396e-06 1.03928392114753e-05 0.905891614573257 0.565217391304348 18.5 18 5 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00914526352738071 0.0195108095943969 0.90153636642627 0.5625 18.5 18 5 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0307306000640548 0.0583840372378504 0.90153636642627 0.5625 18.5 18 5 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.11435049288556 0.181001948138099 0.90153636642627 0.5625 18.5 18 5 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.11435049288556 0.181001948138099 0.90153636642627 0.5625 18.5 18 5 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 3.38050095822647e-06 1.44893158540852e-05 0.900299691026508 0.561728395061728 18.5 18 5 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0290432800626383 0.0553260877230713 0.895643971874464 0.558823529411765 18.5 18 5 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00824934688077496 0.0179754054867357 0.893830927396985 0.557692307692308 18.5 18 5 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 8.27647755044395e-07 3.82384011502654e-06 0.893188807477878 0.557291666666667 18.5 18 5 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.106423787715298 0.169397147560256 0.890406287828415 0.555555555555556 18.5 18 5 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.234441670254508 0.326748772548644 0.890406287828415 0.555555555555556 18.5 18 5 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.234441670254508 0.326748772548644 0.890406287828415 0.555555555555556 18.5 18 5 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.234441670254508 0.326748772548644 0.890406287828415 0.555555555555556 18.5 18 5 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.234441670254508 0.326748772548644 0.890406287828415 0.555555555555556 18.5 18 5 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.234441670254508 0.326748772548644 0.890406287828415 0.555555555555556 18.5 18 5 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0529403972981517 0.0927760903390023 0.890406287828415 0.555555555555556 18.5 18 5 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0529403972981517 0.0927760903390023 0.890406287828415 0.555555555555556 18.5 18 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0497162346085417 0.0874489516043941 0.884265554808908 0.551724137931034 18.5 18 5 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0497162346085417 0.0874489516043941 0.884265554808908 0.551724137931034 18.5 18 5 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0990417791053927 0.157823574095155 0.88150222495013 0.55 18.5 18 5 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0990417791053927 0.157823574095155 0.88150222495013 0.55 18.5 18 5 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 6.42568246315079e-08 3.46354020646348e-07 0.879930919736316 0.549019607843137 18.5 18 5 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00596176944214203 0.0136832224454324 0.876493689581096 0.546875 18.5 18 5 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0109684826933274 0.0231574938762683 0.874217082595171 0.545454545454545 18.5 18 5 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0921863936405465 0.147893165896841 0.874217082595171 0.545454545454545 18.5 18 5 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.21280261805563 0.299227396732373 0.874217082595171 0.545454545454545 18.5 18 5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.21280261805563 0.299227396732373 0.874217082595171 0.545454545454545 18.5 18 5 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.21280261805563 0.299227396732373 0.874217082595171 0.545454545454545 18.5 18 5 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0437870243194698 0.0789832345732642 0.874217082595171 0.545454545454545 18.5 18 5 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0437870243194698 0.0789832345732642 0.874217082595171 0.545454545454545 18.5 18 5 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00145377489739816 0.00387401063482693 0.872598162071846 0.544444444444444 18.5 18 5 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 4.73798077246069e-05 0.000171555894127521 0.868576972384879 0.541935483870968 18.5 18 5 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0361329006248545 0.0670366591775332 0.863009171279848 0.538461538461538 18.5 18 5 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0361329006248545 0.0670366591775332 0.863009171279848 0.538461538461538 18.5 18 5 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0361329006248545 0.0670366591775332 0.863009171279848 0.538461538461538 18.5 18 5 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.194029534409503 0.274184734324452 0.863009171279848 0.538461538461538 18.5 18 5 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.194029534409503 0.274184734324452 0.863009171279848 0.538461538461538 18.5 18 5 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.194029534409503 0.274184734324452 0.863009171279848 0.538461538461538 18.5 18 5 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.194029534409503 0.274184734324452 0.863009171279848 0.538461538461538 18.5 18 5 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.194029534409503 0.274184734324452 0.863009171279848 0.538461538461538 18.5 18 5 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0338856935604359 0.0638357701350463 0.860002170683054 0.536585365853659 18.5 18 5 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.64847340828397e-11 4.65829412675217e-10 0.858862746690099 0.535874439461883 18.5 18 5 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0694168169557472 0.117455565431663 0.854790036315278 0.533333333333333 18.5 18 5 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.177531432916512 0.252122983074049 0.854790036315278 0.533333333333333 18.5 18 5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.177531432916512 0.252122983074049 0.854790036315278 0.533333333333333 18.5 18 5 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.177531432916512 0.252122983074049 0.854790036315278 0.533333333333333 18.5 18 5 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0262130138348514 0.0500014995804203 0.850428862660608 0.530612244897959 18.5 18 5 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.162893310205554 0.232029209632136 0.848504815460019 0.529411764705882 18.5 18 5 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 5.61717221876263e-06 2.3236151358428e-05 0.846077047747687 0.527896995708155 18.5 18 5 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0563356913617463 0.0962966785919103 0.845885973436994 0.527777777777778 18.5 18 5 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000136478165806649 0.000453758013885191 0.845612842673856 0.52760736196319 18.5 18 5 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 5.68287127768345e-11 5.65505302667381e-10 0.845076513175332 0.527272727272727 18.5 18 5 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.00336547947425968 0.00807601566926057 0.84354279899534 0.526315789473684 18.5 18 5 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.149809355487114 0.223761677958146 0.84354279899534 0.526315789473684 18.5 18 5 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.149809355487114 0.223761677958146 0.84354279899534 0.526315789473684 18.5 18 5 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000279413076935704 0.000864358279303274 0.836645908185944 0.522012578616352 18.5 18 5 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000279413076935704 0.000864358279303274 0.836645908185944 0.522012578616352 18.5 18 5 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.127418983291891 0.199688560819781 0.836207644221468 0.521739130434783 18.5 18 5 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0374515154345251 0.0693925865407932 0.834755894839139 0.520833333333333 18.5 18 5 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0350246764402604 0.0653212510805906 0.833420285407396 0.52 18.5 18 5 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.117780912376154 0.186018022543027 0.833420285407396 0.52 18.5 18 5 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0306567041305304 0.0583215106654342 0.831045868639854 0.518518518518518 18.5 18 5 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.109010451987454 0.173127090600611 0.831045868639854 0.518518518518518 18.5 18 5 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.00838768042388794 0.0179754054867357 0.82964915289424 0.517647058823529 18.5 18 5 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.00838768042388794 0.0179754054867357 0.82964915289424 0.517647058823529 18.5 18 5 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00201146826658276 0.0051388139018802 0.827639942948707 0.516393442622951 18.5 18 5 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0936847910561931 0.149622286950576 0.827216164176075 0.516129032258065 18.5 18 5 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0936847910561931 0.149622286950576 0.827216164176075 0.516129032258065 18.5 18 5 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0936847910561931 0.149622286950576 0.827216164176075 0.516129032258065 18.5 18 5 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0936847910561931 0.149622286950576 0.827216164176075 0.516129032258065 18.5 18 5 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0869721104517823 0.14000148548969 0.825649466895439 0.515151515151515 18.5 18 5 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0565073461937016 0.0962966785919103 0.819173784802141 0.511111111111111 18.5 18 5 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00844276476369918 0.01806624700563 0.818415992216756 0.51063829787234 18.5 18 5 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00202792019748589 0.00517155993014771 0.812813739889081 0.507142857142857 18.5 18 5 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00190759099969502 0.00496252649463623 0.812652499313821 0.507042253521127 18.5 18 5 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00290157471962045 0.0070822312624698 0.807215043418169 0.503649635036496 18.5 18 5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.219362832695811 0.307843501899545 0.801365659045573 0.5 18.5 18 5 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00388013028309799 0.00923315283085023 0.801365659045573 0.5 18.5 18 5 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0120152749887936 0.0250699945880548 0.801365659045573 0.5 18.5 18 5 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.122644334213614 0.192900324661118 0.801365659045573 0.5 18.5 18 5 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.155624734455604 0.2302463746457 0.801365659045573 0.5 18.5 18 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.155624734455604 0.2302463746457 0.801365659045573 0.5 18.5 18 5 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.200576931868834 0.283155728223563 0.801365659045573 0.5 18.5 18 5 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.240712372947465 0.334505572953362 0.801365659045573 0.5 18.5 18 5 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.240712372947465 0.334505572953362 0.801365659045573 0.5 18.5 18 5 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.265242699076931 0.36327272452981 0.801365659045573 0.5 18.5 18 5 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.265242699076931 0.36327272452981 0.801365659045573 0.5 18.5 18 5 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.265242699076931 0.36327272452981 0.801365659045573 0.5 18.5 18 5 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.293840399701183 0.395586460524866 0.801365659045573 0.5 18.5 18 5 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.293840399701183 0.395586460524866 0.801365659045573 0.5 18.5 18 5 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.293840399701183 0.395586460524866 0.801365659045573 0.5 18.5 18 5 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.293840399701183 0.395586460524866 0.801365659045573 0.5 18.5 18 5 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.293840399701183 0.395586460524866 0.801365659045573 0.5 18.5 18 5 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.327856489026498 0.433235811010697 0.801365659045573 0.5 18.5 18 5 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.327856489026498 0.433235811010697 0.801365659045573 0.5 18.5 18 5 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.327856489026498 0.433235811010697 0.801365659045573 0.5 18.5 18 5 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.327856489026498 0.433235811010697 0.801365659045573 0.5 18.5 18 5 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.327856489026498 0.433235811010697 0.801365659045573 0.5 18.5 18 5 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.327856489026498 0.433235811010697 0.801365659045573 0.5 18.5 18 5 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.327856489026498 0.433235811010697 0.801365659045573 0.5 18.5 18 5 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.327856489026498 0.433235811010697 0.801365659045573 0.5 18.5 18 5 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00484450388188754 0.0113099202111409 0.795516274672978 0.496350364963504 18.5 18 5 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00338972939307044 0.00812051334400545 0.782729248370095 0.488372093023256 18.5 18 5 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0436514243662082 0.0789832345732642 0.78027708907069 0.486842105263158 18.5 18 5 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.133834089980843 0.209051492911898 0.779707127720017 0.486486486486487 18.5 18 5 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.156218191871808 0.2302463746457 0.777081851195707 0.484848484848485 18.5 18 5 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.123518526469874 0.193789264792316 0.766523673869679 0.478260869565217 18.5 18 5 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.235684414353601 0.328159414506041 0.766523673869679 0.478260869565217 18.5 18 5 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.092123401178009 0.147893165896841 0.761954233190873 0.475409836065574 18.5 18 5 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.281960962183639 0.385798508833959 0.759188519095806 0.473684210526316 18.5 18 5 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.113506959813751 0.180067339816018 0.757654804915815 0.472727272727273 18.5 18 5 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.309884873162497 0.416398653928454 0.754226502631128 0.470588235294118 18.5 18 5 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.2275621067823 0.318721336566154 0.747941281775868 0.466666666666667 18.5 18 5 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.2275621067823 0.318721336566154 0.747941281775868 0.466666666666667 18.5 18 5 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.341990056967297 0.448940822015188 0.747941281775868 0.466666666666667 18.5 18 5 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.341990056967297 0.448940822015188 0.747941281775868 0.466666666666667 18.5 18 5 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.246893027750704 0.342759783891953 0.744125254828032 0.464285714285714 18.5 18 5 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.108950876367518 0.173127090600611 0.743295683752416 0.463768115942029 18.5 18 5 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.379392569951194 0.489465841651205 0.739722146811298 0.461538461538462 18.5 18 5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.379392569951194 0.489465841651205 0.739722146811298 0.461538461538462 18.5 18 5 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.379392569951194 0.489465841651205 0.739722146811298 0.461538461538462 18.5 18 5 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.218540677296854 0.306992481533488 0.736390065068905 0.459459459459459 18.5 18 5 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.142444200396825 0.220324018657263 0.735679949287739 0.459016393442623 18.5 18 5 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.292102133746426 0.395115338708331 0.734585187458442 0.458333333333333 18.5 18 5 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.292102133746426 0.395115338708331 0.734585187458442 0.458333333333333 18.5 18 5 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.117228172595821 0.185350766226504 0.730358575332674 0.455696202531646 18.5 18 5 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.423734714835554 0.528461436644166 0.728514235495976 0.454545454545455 18.5 18 5 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.423734714835554 0.528461436644166 0.728514235495976 0.454545454545455 18.5 18 5 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.423734714835554 0.528461436644166 0.728514235495976 0.454545454545455 18.5 18 5 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.423734714835554 0.528461436644166 0.728514235495976 0.454545454545455 18.5 18 5 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.423734714835554 0.528461436644166 0.728514235495976 0.454545454545455 18.5 18 5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.423734714835554 0.528461436644166 0.728514235495976 0.454545454545455 18.5 18 5 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.423734714835554 0.528461436644166 0.728514235495976 0.454545454545455 18.5 18 5 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.423734714835554 0.528461436644166 0.728514235495976 0.454545454545455 18.5 18 5 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.34854789607757 0.457127793657495 0.721229093141016 0.45 18.5 18 5 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0426016269087393 0.0780207401430322 0.71906324000846 0.448648648648649 18.5 18 5 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.298607123111142 0.401623758210921 0.718465763282238 0.448275862068966 18.5 18 5 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.382302505535845 0.489465841651205 0.712325030262732 0.444444444444444 18.5 18 5 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.154392425549058 0.229812156439654 0.706580473567065 0.440860215053763 18.5 18 5 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0474518798188153 0.0836728934103769 0.701597243662389 0.437751004016064 18.5 18 5 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.420761588982723 0.528461436644166 0.701194951664876 0.4375 18.5 18 5 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.420761588982723 0.528461436644166 0.701194951664876 0.4375 18.5 18 5 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.420761588982723 0.528461436644166 0.701194951664876 0.4375 18.5 18 5 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.420761588982723 0.528461436644166 0.701194951664876 0.4375 18.5 18 5 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.352935665009668 0.46245621667473 0.694516904506163 0.433333333333333 18.5 18 5 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.148642549587131 0.223761677958146 0.694096240118213 0.433070866141732 18.5 18 5 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.208307607671228 0.293777726180532 0.692088523721177 0.431818181818182 18.5 18 5 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.416891286865844 0.528461436644166 0.686884850610491 0.428571428571429 18.5 18 5 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.465004973106891 0.577401463116149 0.686884850610491 0.428571428571429 18.5 18 5 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.465004973106891 0.577401463116149 0.686884850610491 0.428571428571429 18.5 18 5 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.465004973106891 0.577401463116149 0.686884850610491 0.428571428571429 18.5 18 5 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.465004973106891 0.577401463116149 0.686884850610491 0.428571428571429 18.5 18 5 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.465004973106891 0.577401463116149 0.686884850610491 0.428571428571429 18.5 18 5 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0874568784080726 0.140622754773658 0.685089073223274 0.427450980392157 18.5 18 5 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.329398914793743 0.433235811010697 0.682013326847296 0.425531914893617 18.5 18 5 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.379796653197281 0.489465841651205 0.679946619796244 0.424242424242424 18.5 18 5 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.379796653197281 0.489465841651205 0.679946619796244 0.424242424242424 18.5 18 5 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.379796653197281 0.489465841651205 0.679946619796244 0.424242424242424 18.5 18 5 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.516516368502962 0.628207514854457 0.667804715871311 0.416666666666667 18.5 18 5 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.516516368502962 0.628207514854457 0.667804715871311 0.416666666666667 18.5 18 5 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.370461816282543 0.482753813708845 0.66528469807557 0.415094339622642 18.5 18 5 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.498375290056881 0.607181539170326 0.659948189802237 0.411764705882353 18.5 18 5 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.484877872056693 0.599983662553629 0.655662811946378 0.409090909090909 18.5 18 5 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.395606759611196 0.50353168061425 0.644397127892317 0.402061855670103 18.5 18 5 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.067998197937042 0.115192185314775 0.641092527236458 0.4 18.5 18 5 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.403089879221691 0.512597764193447 0.63522887607271 0.396341463414634 18.5 18 5 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.533806129383447 0.648681573110713 0.62964444639295 0.392857142857143 18.5 18 5 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.554523176347233 0.670991904712681 0.620412123132057 0.387096774193548 18.5 18 5 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.554523176347233 0.670991904712681 0.620412123132057 0.387096774193548 18.5 18 5 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.602218742597817 0.726234975183638 0.616435122342749 0.384615384615385 18.5 18 5 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.568633745169908 0.687481579759371 0.61056431165377 0.380952380952381 18.5 18 5 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.622766914130292 0.733607051992886 0.60102424428418 0.375 18.5 18 5 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.622766914130292 0.733607051992886 0.60102424428418 0.375 18.5 18 5 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.629698000839181 0.738522580949709 0.59360419188561 0.37037037037037 18.5 18 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.64046739855456 0.743381001748075 0.590479959296738 0.368421052631579 18.5 18 5 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.64046739855456 0.743381001748075 0.590479959296738 0.368421052631579 18.5 18 5 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.645054491851708 0.748094981177653 0.590479959296738 0.368421052631579 18.5 18 5 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.701871240727359 0.808714798020269 0.560955961331901 0.35 18.5 18 5 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.815543985833085 0.905947768805995 0.554791610108474 0.346153846153846 18.5 18 5 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.886223493420994 0.960679483292189 0.55147744278405 0.344086021505376 18.5 18 5 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.825830851471811 0.915944896059538 0.550432977930293 0.343434343434343 18.5 18 5 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.789572269441869 0.882609064741382 0.544323843880012 0.339622641509434 18.5 18 5 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.749805441697644 0.852896197870301 0.534243772697049 0.333333333333333 18.5 18 5 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.870043832841605 0.948714462937628 0.52748119329582 0.329113924050633 18.5 18 5 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.828022754711309 0.917660732051552 0.521819498913396 0.325581395348837 18.5 18 5 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.805385062356553 0.89597821671049 0.512874021789167 0.32 18.5 18 5 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.800269153917528 0.893864211950269 0.506125679397204 0.315789473684211 18.5 18 5 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.849822854784068 0.937074883031374 0.506125679397204 0.315789473684211 18.5 18 5 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.845384178946878 0.936172518787087 0.500853536903483 0.3125 18.5 18 5 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.899807456417681 0.971491661974477 0.490632036150351 0.306122448979592 18.5 18 5 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.898160641504787 0.970736504766211 0.465309092349042 0.290322580645161 18.5 18 5 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.877061053269608 0.95198922868242 0.457923233740328 0.285714285714286 18.5 18 5 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.917498053946337 0.98387319575406 0.457923233740328 0.285714285714286 18.5 18 5 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999988707871896 1 0.45438259018048 0.283505154639175 18.5 18 5 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.973356406835026 1 0.4514736107299 0.28169014084507 18.5 18 5 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.99945702075602 1 0.450537375131613 0.28110599078341 18.5 18 5 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.901677832461607 0.972772976188679 0.448764769065521 0.28 18.5 18 5 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999955629752916 1 0.440751112475065 0.275 18.5 18 5 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.997771811709182 1 0.415522934319927 0.259259259259259 18.5 18 5 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999942760472528 1 0.400682829522787 0.25 18.5 18 5 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.982809864697494 1 0.400682829522787 0.25 18.5 18 5 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.974107742800275 1 0.373970640887934 0.233333333333333 18.5 18 5 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999658982121904 1 0.356162515131366 0.222222222222222 18.5 18 5 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.972970718395747 1 0.348419851758945 0.217391304347826 18.5 18 5 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.324314229773271 0.202350965575147 18.5 18 5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999045972563783 1 0.30051212214209 0.1875 18.5 18 5 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.994849444706413 1 0.286202021087705 0.178571428571429 18.5 18 5 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.998280566557631 1 0.274753940244197 0.171428571428571 18.5 18 5 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.266638844962722 0.166365280289331 18.5 18 5 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.999398660269807 1 0.235695782072227 0.147058823529412 18.5 18 5 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999996062411184 1 0.170503331711824 0.106382978723404 18.5 18 5 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 2.22587334720367e-06 1.24701487128772e-05 1.72066725479188 1 18.1 18 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 2.22587334720367e-06 1.24701487128772e-05 1.72066725479188 1 18.1 18 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 6.05955020874775e-06 3.1241811402348e-05 1.72066725479188 1 18.1 18 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 6.05955020874775e-06 3.1241811402348e-05 1.72066725479188 1 18.1 18 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.000332643936417306 0.00110081935237634 1.72066725479188 1 18.1 18 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000332643936417306 0.00110081935237634 1.72066725479188 1 18.1 18 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.000332643936417306 0.00110081935237634 1.72066725479188 1 18.1 18 1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.00246386516085518 0.00639795643046883 1.72066725479188 1 18.1 18 1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.00246386516085518 0.00639795643046883 1.72066725479188 1 18.1 18 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 4.49008023539184e-05 0.000183076910457381 1.72066725479188 1 18.1 18 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 4.49008023539184e-05 0.000183076910457381 1.72066725479188 1 18.1 18 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.000122215947980188 0.000443656362183183 1.72066725479188 1 18.1 18 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.000122215947980188 0.000443656362183183 1.72066725479188 1 18.1 18 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.000905334969624922 0.00265080588842853 1.72066725479188 1 18.1 18 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.000905334969624922 0.00265080588842853 1.72066725479188 1 18.1 18 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000905334969624922 0.00265080588842853 1.72066725479188 1 18.1 18 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.000905334969624922 0.00265080588842853 1.72066725479188 1 18.1 18 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00670505795820338 0.0156158714803984 1.72066725479188 1 18.1 18 1 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00670505795820338 0.0156158714803984 1.72066725479188 1 18.1 18 1 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.00670505795820338 0.0156158714803984 1.72066725479188 1 18.1 18 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00670505795820338 0.0156158714803984 1.72066725479188 1 18.1 18 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 1.64952260578955e-05 7.70945516208855e-05 1.72066725479188 1 18.1 18 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 2.25110956434757e-10 2.27186447522454e-09 1.6544877449922 0.961538461538462 18.1 18 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.54449702438316e-09 1.37363704106077e-08 1.64897278584222 0.958333333333333 18.1 18 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 4.03550369626417e-09 3.35819985952276e-08 1.64585563501832 0.956521739130435 18.1 18 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.73928307545652e-08 2.07340415764608e-07 1.63873071884941 0.952380952380952 18.1 18 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 7.1139965178122e-08 5.0114935865578e-07 1.63463389205229 0.95 18.1 18 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 7.1139965178122e-08 5.0114935865578e-07 1.63463389205229 0.95 18.1 18 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 1.2268853088007e-06 7.27440747676414e-06 1.61945153392177 0.941176470588235 18.1 18 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 3.1503933890685e-06 1.67276484800167e-05 1.61312555136739 0.9375 18.1 18 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 3.1503933890685e-06 1.67276484800167e-05 1.61312555136739 0.9375 18.1 18 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 3.1503933890685e-06 1.67276484800167e-05 1.61312555136739 0.9375 18.1 18 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 3.1503933890685e-06 1.67276484800167e-05 1.61312555136739 0.9375 18.1 18 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 3.1503933890685e-06 1.67276484800167e-05 1.61312555136739 0.9375 18.1 18 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 8.05974043737136e-06 3.99617095553291e-05 1.60595610447242 0.933333333333333 18.1 18 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 2.05334863528747e-05 9.33519203838359e-05 1.59776245087818 0.928571428571429 18.1 18 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.96715504565092e-09 1.69306894168103e-08 1.5932104211036 0.925925925925926 18.1 18 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 4.97013390028765e-09 4.08815060121926e-08 1.58830823519251 0.923076923076923 18.1 18 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 4.97013390028765e-09 4.08815060121926e-08 1.58830823519251 0.923076923076923 18.1 18 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 5.20636725472767e-05 0.000202977002834999 1.58830823519251 0.923076923076923 18.1 18 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 5.20636725472767e-05 0.000202977002834999 1.58830823519251 0.923076923076923 18.1 18 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 5.20636725472767e-05 0.000202977002834999 1.58830823519251 0.923076923076923 18.1 18 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000131287660398521 0.000467055851867739 1.57727831689256 0.916666666666667 18.1 18 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000131287660398521 0.000467055851867739 1.57727831689256 0.916666666666667 18.1 18 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000131287660398521 0.000467055851867739 1.57727831689256 0.916666666666667 18.1 18 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000131287660398521 0.000467055851867739 1.57727831689256 0.916666666666667 18.1 18 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.000131287660398521 0.000467055851867739 1.57727831689256 0.916666666666667 18.1 18 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 7.86598440736595e-08 5.4869097116087e-07 1.57104401524476 0.91304347826087 18.1 18 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000328956565314146 0.00109626508768625 1.56424295890171 0.909090909090909 18.1 18 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.000328956565314146 0.00109626508768625 1.56424295890171 0.909090909090909 18.1 18 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.000328956565314146 0.00109626508768625 1.56424295890171 0.909090909090909 18.1 18 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 3.23954409493528e-10 3.17922154971925e-09 1.55935469965514 0.90625 18.1 18 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 4.86737742201911e-07 3.02457557708873e-06 1.55679418290694 0.904761904761905 18.1 18 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 1.20281027537124e-06 7.16150218348651e-06 1.5486005293127 0.9 18.1 18 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.000818052258616614 0.00244043682182692 1.5486005293127 0.9 18.1 18 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.000818052258616614 0.00244043682182692 1.5486005293127 0.9 18.1 18 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 2.95754452273036e-06 1.60022275887654e-05 1.53954438586642 0.894736842105263 18.1 18 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 7.23215389254645e-06 3.62371654545549e-05 1.52948200425945 0.888888888888889 18.1 18 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 7.23215389254645e-06 3.62371654545549e-05 1.52948200425945 0.888888888888889 18.1 18 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 7.23215389254645e-06 3.62371654545549e-05 1.52948200425945 0.888888888888889 18.1 18 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 7.23215389254645e-06 3.62371654545549e-05 1.52948200425945 0.888888888888889 18.1 18 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00201606784391425 0.00540275808265533 1.52948200425945 0.888888888888889 18.1 18 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00201606784391425 0.00540275808265533 1.52948200425945 0.888888888888889 18.1 18 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00201606784391425 0.00540275808265533 1.52948200425945 0.888888888888889 18.1 18 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 1.75767039910769e-05 8.14711719195518e-05 1.51823581305166 0.882352941176471 18.1 18 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.75767039910769e-05 8.14711719195518e-05 1.51823581305166 0.882352941176471 18.1 18 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.70158754656394e-07 1.14215050884929e-06 1.51418718421686 0.88 18.1 18 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 4.0922271298059e-07 2.6230807232945e-06 1.5055838479429 0.875 18.1 18 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 4.24251697754918e-05 0.00017704110437104 1.5055838479429 0.875 18.1 18 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 4.24251697754918e-05 0.00017704110437104 1.5055838479429 0.875 18.1 18 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00491417220207823 0.0117329983952304 1.5055838479429 0.875 18.1 18 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.08938465208407e-12 1.82375807048898e-11 1.50100760524398 0.872340425531915 18.1 18 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 7.72510918830826e-18 2.68117814023479e-16 1.4962323954712 0.869565217391304 18.1 18 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 9.78845547247718e-07 5.8772034334747e-06 1.4962323954712 0.869565217391304 18.1 18 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 2.45337915568914e-10 2.45856235108849e-09 1.49426366863506 0.868421052631579 18.1 18 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.16606093729284e-12 8.20028477922216e-11 1.49124495415297 0.866666666666667 18.1 18 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.35773762039124e-08 1.79415007155975e-07 1.49124495415297 0.866666666666667 18.1 18 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.35773762039124e-08 1.79415007155975e-07 1.49124495415297 0.866666666666667 18.1 18 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000101612834803646 0.000372667690529867 1.49124495415297 0.866666666666667 18.1 18 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000101612834803646 0.000372667690529867 1.49124495415297 0.866666666666667 18.1 18 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 5.82088345505212e-10 5.63477357587699e-09 1.48814465279298 0.864864864864865 18.1 18 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.37557382421702e-09 1.25477022555181e-08 1.48168569162634 0.861111111111111 18.1 18 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.37557382421702e-09 1.25477022555181e-08 1.48168569162634 0.861111111111111 18.1 18 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000241244789713689 0.000827208037982119 1.47485764696447 0.857142857142857 18.1 18 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000241244789713689 0.000827208037982119 1.47485764696447 0.857142857142857 18.1 18 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000241244789713689 0.000827208037982119 1.47485764696447 0.857142857142857 18.1 18 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.000241244789713689 0.000827208037982119 1.47485764696447 0.857142857142857 18.1 18 1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0118150463082367 0.0261474508501102 1.47485764696447 0.857142857142857 18.1 18 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0118150463082367 0.0261474508501102 1.47485764696447 0.857142857142857 18.1 18 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0118150463082367 0.0261474508501102 1.47485764696447 0.857142857142857 18.1 18 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0118150463082367 0.0261474508501102 1.47485764696447 0.857142857142857 18.1 18 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0118150463082367 0.0261474508501102 1.47485764696447 0.857142857142857 18.1 18 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 4.80029375695134e-12 6.69688040798212e-11 1.46973661346807 0.854166666666667 18.1 18 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.42531145143403e-10 4.31316314752782e-09 1.4625671665731 0.85 18.1 18 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 1.29010385910986e-05 6.22311115767233e-05 1.4625671665731 0.85 18.1 18 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.000567019593580365 0.00177724423274198 1.45594921559313 0.846153846153846 18.1 18 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000567019593580365 0.00177724423274198 1.45594921559313 0.846153846153846 18.1 18 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000567019593580365 0.00177724423274198 1.45594921559313 0.846153846153846 18.1 18 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.26927789829583e-14 2.82216007699214e-13 1.44754546831698 0.841269841269841 18.1 18 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.66430849418262e-06 9.43550194112296e-06 1.44536049402518 0.84 18.1 18 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 1.66430849418262e-06 9.43550194112296e-06 1.44536049402518 0.84 18.1 18 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 1.66430849418262e-06 9.43550194112296e-06 1.44536049402518 0.84 18.1 18 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 3.82695971858335e-06 2.00211899983239e-05 1.43388937899324 0.833333333333333 18.1 18 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00131730108989227 0.00372118771013325 1.43388937899324 0.833333333333333 18.1 18 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00131730108989227 0.00372118771013325 1.43388937899324 0.833333333333333 18.1 18 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00131730108989227 0.00372118771013325 1.43388937899324 0.833333333333333 18.1 18 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00131730108989227 0.00372118771013325 1.43388937899324 0.833333333333333 18.1 18 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0279110219449443 0.0547071408094432 1.43388937899324 0.833333333333333 18.1 18 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 6.92994544837289e-05 0.000265803568006324 1.43388937899324 0.833333333333333 18.1 18 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.67063204881828e-09 1.45847202789473e-08 1.42689479665668 0.829268292682927 18.1 18 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.67063204881828e-09 1.45847202789473e-08 1.42689479665668 0.829268292682927 18.1 18 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.99721094754929e-11 3.25574899111652e-10 1.41702009218155 0.823529411764706 18.1 18 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000158384676769427 0.000559259044771452 1.41702009218155 0.823529411764706 18.1 18 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.03225907395726e-12 5.73790466224117e-11 1.41340524500762 0.821428571428571 18.1 18 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 8.54942655021941e-09 6.76830461362841e-08 1.41182954239334 0.82051282051282 18.1 18 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 1.97716526778434e-05 9.04664365291676e-05 1.40781866301154 0.818181818181818 18.1 18 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.97716526778434e-05 9.04664365291676e-05 1.40781866301154 0.818181818181818 18.1 18 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00301898287847771 0.00759012833228582 1.40781866301154 0.818181818181818 18.1 18 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00301898287847771 0.00759012833228582 1.40781866301154 0.818181818181818 18.1 18 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00301898287847771 0.00759012833228582 1.40781866301154 0.818181818181818 18.1 18 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.21849711077002e-12 1.86443160067284e-11 1.40521159141337 0.816666666666667 18.1 18 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.21849711077002e-12 1.86443160067284e-11 1.40521159141337 0.816666666666667 18.1 18 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.21849711077002e-12 1.86443160067284e-11 1.40521159141337 0.816666666666667 18.1 18 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.21849711077002e-12 1.86443160067284e-11 1.40521159141337 0.816666666666667 18.1 18 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.21849711077002e-12 1.86443160067284e-11 1.40521159141337 0.816666666666667 18.1 18 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.21849711077002e-12 1.86443160067284e-11 1.40521159141337 0.816666666666667 18.1 18 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.21849711077002e-12 1.86443160067284e-11 1.40521159141337 0.816666666666667 18.1 18 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.51334536323538e-10 1.58344886167938e-09 1.40462633044235 0.816326530612245 18.1 18 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 2.5242655554962e-06 1.40313667401215e-05 1.40202517057116 0.814814814814815 18.1 18 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000358092716592318 0.00117682664136459 1.39804214451841 0.8125 18.1 18 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000358092716592318 0.00117682664136459 1.39804214451841 0.8125 18.1 18 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000358092716592318 0.00117682664136459 1.39804214451841 0.8125 18.1 18 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 6.05322112023326e-12 8.12616382461503e-11 1.39433380991756 0.810344827586207 18.1 18 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 6.05322112023326e-12 8.12616382461503e-11 1.39433380991756 0.810344827586207 18.1 18 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 4.43586593371223e-05 0.000182717573707329 1.392921111022 0.80952380952381 18.1 18 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.50872997135899e-10 7.12328183282922e-09 1.39117778047003 0.808510638297872 18.1 18 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 5.6353467390519e-06 2.93739868486112e-05 1.38976970579344 0.807692307692308 18.1 18 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.61155515347455e-30 7.98524298339428e-28 1.38728797417596 0.80625 18.1 18 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.66080380936194e-09 1.45847202789473e-08 1.38401496581086 0.804347826086957 18.1 18 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.21310979426236e-10 2.24946802659667e-09 1.38328151855818 0.803921568627451 18.1 18 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.21310979426236e-10 2.24946802659667e-09 1.38328151855818 0.803921568627451 18.1 18 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 3.65512036189911e-09 3.05955074998966e-08 1.37653380383351 0.8 18.1 18 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 6.20608244907158e-24 5.19485607354638e-22 1.37653380383351 0.8 18.1 18 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.91872356142326e-16 1.065750429826e-14 1.37653380383351 0.8 18.1 18 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.91872356142326e-16 1.065750429826e-14 1.37653380383351 0.8 18.1 18 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.91872356142326e-16 1.065750429826e-14 1.37653380383351 0.8 18.1 18 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.91872356142326e-16 1.065750429826e-14 1.37653380383351 0.8 18.1 18 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.09692375617458e-07 1.39435631076469e-06 1.37653380383351 0.8 18.1 18 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.24775646161863e-05 6.03931103701807e-05 1.37653380383351 0.8 18.1 18 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.24775646161863e-05 6.03931103701807e-05 1.37653380383351 0.8 18.1 18 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000799772609353858 0.00241117886252233 1.37653380383351 0.8 18.1 18 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.000799772609353858 0.00241117886252233 1.37653380383351 0.8 18.1 18 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000799772609353858 0.00241117886252233 1.37653380383351 0.8 18.1 18 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000799772609353858 0.00241117886252233 1.37653380383351 0.8 18.1 18 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000799772609353858 0.00241117886252233 1.37653380383351 0.8 18.1 18 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.89310350025529e-15 6.64013916268271e-14 1.37653380383351 0.8 18.1 18 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 9.85461982934339e-05 0.000363293368320094 1.37653380383351 0.8 18.1 18 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 9.85461982934339e-05 0.000363293368320094 1.37653380383351 0.8 18.1 18 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 9.85461982934339e-05 0.000363293368320094 1.37653380383351 0.8 18.1 18 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0068081301851048 0.0158041912779839 1.37653380383351 0.8 18.1 18 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0068081301851048 0.0158041912779839 1.37653380383351 0.8 18.1 18 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.4442809949068e-17 1.06548083820704e-15 1.36913308445806 0.795698924731183 18.1 18 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 8.00226210122082e-09 6.43345704521877e-08 1.368712589039 0.795454545454545 18.1 18 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 2.73816188373576e-05 0.000119521606152024 1.36219491004357 0.791666666666667 18.1 18 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.64071255670965e-12 2.40694223525549e-11 1.36112484334283 0.791044776119403 18.1 18 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000216559644304342 0.000751620424012386 1.35842151694096 0.789473684210526 18.1 18 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000216559644304342 0.000751620424012386 1.35842151694096 0.789473684210526 18.1 18 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.40482237378622e-13 2.63034504986551e-12 1.35359157376962 0.786666666666667 18.1 18 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.40482237378622e-13 2.63034504986551e-12 1.35359157376962 0.786666666666667 18.1 18 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.40482237378622e-13 2.63034504986551e-12 1.35359157376962 0.786666666666667 18.1 18 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.40482237378622e-13 2.63034504986551e-12 1.35359157376962 0.786666666666667 18.1 18 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.40482237378622e-13 2.63034504986551e-12 1.35359157376962 0.786666666666667 18.1 18 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.40482237378622e-13 2.63034504986551e-12 1.35359157376962 0.786666666666667 18.1 18 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 7.66543803618936e-06 3.81395745646764e-05 1.35195284305077 0.785714285714286 18.1 18 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 7.66543803618936e-06 3.81395745646764e-05 1.35195284305077 0.785714285714286 18.1 18 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00176152720775818 0.0047655004118629 1.35195284305077 0.785714285714286 18.1 18 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00176152720775818 0.0047655004118629 1.35195284305077 0.785714285714286 18.1 18 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00176152720775818 0.0047655004118629 1.35195284305077 0.785714285714286 18.1 18 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00176152720775818 0.0047655004118629 1.35195284305077 0.785714285714286 18.1 18 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 5.95065529920992e-05 0.000230102785075427 1.34660915592408 0.782608695652174 18.1 18 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 5.95065529920992e-05 0.000230102785075427 1.34660915592408 0.782608695652174 18.1 18 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 5.95065529920992e-05 0.000230102785075427 1.34660915592408 0.782608695652174 18.1 18 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 1.65241308814969e-05 7.70945516208855e-05 1.33829675372702 0.777777777777778 18.1 18 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 1.65241308814969e-05 7.70945516208855e-05 1.33829675372702 0.777777777777778 18.1 18 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 1.65241308814969e-05 7.70945516208855e-05 1.33829675372702 0.777777777777778 18.1 18 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 1.65241308814969e-05 7.70945516208855e-05 1.33829675372702 0.777777777777778 18.1 18 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00047018295476937 0.00149835799330447 1.33829675372702 0.777777777777778 18.1 18 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00047018295476937 0.00149835799330447 1.33829675372702 0.777777777777778 18.1 18 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0150575374556521 0.0326132051741142 1.33829675372702 0.777777777777778 18.1 18 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0150575374556521 0.0326132051741142 1.33829675372702 0.777777777777778 18.1 18 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0150575374556521 0.0326132051741142 1.33829675372702 0.777777777777778 18.1 18 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0150575374556521 0.0326132051741142 1.33829675372702 0.777777777777778 18.1 18 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0150575374556521 0.0326132051741142 1.33829675372702 0.777777777777778 18.1 18 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0150575374556521 0.0326132051741142 1.33829675372702 0.777777777777778 18.1 18 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0150575374556521 0.0326132051741142 1.33829675372702 0.777777777777778 18.1 18 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0150575374556521 0.0326132051741142 1.33829675372702 0.777777777777778 18.1 18 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 6.6290447483333e-23 5.24062815382127e-21 1.33692132026995 0.776978417266187 18.1 18 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.10507855362004e-20 2.78167941990539e-18 1.33671671033419 0.776859504132231 18.1 18 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.10507855362004e-20 2.78167941990539e-18 1.33671671033419 0.776859504132231 18.1 18 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 6.65566021091527e-09 5.38125254552979e-08 1.33439501392024 0.775510204081633 18.1 18 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00012795448197867 0.000460960070520625 1.32960651506646 0.772727272727273 18.1 18 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00012795448197867 0.000460960070520625 1.32960651506646 0.772727272727273 18.1 18 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00381823941093198 0.00948229438351869 1.32359019599376 0.769230769230769 18.1 18 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00381823941093198 0.00948229438351869 1.32359019599376 0.769230769230769 18.1 18 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00381823941093198 0.00948229438351869 1.32359019599376 0.769230769230769 18.1 18 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.19064212361087e-13 5.53693139255886e-12 1.31705394811231 0.765432098765432 18.1 18 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.19064212361087e-13 5.53693139255886e-12 1.31705394811231 0.765432098765432 18.1 18 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 2.75519748623948e-06 1.49642977973999e-05 1.31580437131144 0.764705882352941 18.1 18 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 2.75519748623948e-06 1.49642977973999e-05 1.31580437131144 0.764705882352941 18.1 18 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00100714384601671 0.00288944696145519 1.31580437131144 0.764705882352941 18.1 18 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00100714384601671 0.00288944696145519 1.31580437131144 0.764705882352941 18.1 18 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00100714384601671 0.00288944696145519 1.31580437131144 0.764705882352941 18.1 18 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00100714384601671 0.00288944696145519 1.31580437131144 0.764705882352941 18.1 18 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00100714384601671 0.00288944696145519 1.31580437131144 0.764705882352941 18.1 18 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.00180570311661e-12 8.96580276813774e-11 1.31439859741047 0.763888888888889 18.1 18 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 7.01123574737165e-10 6.69596541510729e-09 1.31237332992601 0.76271186440678 18.1 18 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 7.01123574737165e-10 6.69596541510729e-09 1.31237332992601 0.76271186440678 18.1 18 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.85237104315467e-31 2.92880443823233e-29 1.31098457507953 0.761904761904762 18.1 18 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000271946322953632 0.000919191490648499 1.31098457507953 0.761904761904762 18.1 18 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000271946322953632 0.000919191490648499 1.31098457507953 0.761904761904762 18.1 18 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000271946322953632 0.000919191490648499 1.31098457507953 0.761904761904762 18.1 18 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 6.26164344000719e-08 4.47754704277901e-07 1.3092033460373 0.760869565217391 18.1 18 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.39472696354377e-12 2.06739215533624e-11 1.30683588971535 0.759493670886076 18.1 18 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.39472696354377e-12 2.06739215533624e-11 1.30683588971535 0.759493670886076 18.1 18 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.39472696354377e-12 2.06739215533624e-11 1.30683588971535 0.759493670886076 18.1 18 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 5.7809023119307e-06 3.00227152915233e-05 1.30353579908476 0.757575757575758 18.1 18 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.08058247136163e-11 2.29509213701364e-10 1.29639313717197 0.753424657534247 18.1 18 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.10274461494644e-15 4.90525506076851e-14 1.29050044109391 0.75 18.1 18 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 3.3768434533036e-06 1.78633763347622e-05 1.29050044109391 0.75 18.1 18 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0021248122876385 0.00563055472124689 1.29050044109391 0.75 18.1 18 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0021248122876385 0.00563055472124689 1.29050044109391 0.75 18.1 18 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0021248122876385 0.00563055472124689 1.29050044109391 0.75 18.1 18 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0021248122876385 0.00563055472124689 1.29050044109391 0.75 18.1 18 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0021248122876385 0.00563055472124689 1.29050044109391 0.75 18.1 18 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00812402824423404 0.0186459551476533 1.29050044109391 0.75 18.1 18 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00812402824423404 0.0186459551476533 1.29050044109391 0.75 18.1 18 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.00812402824423404 0.0186459551476533 1.29050044109391 0.75 18.1 18 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0325176686267122 0.0625305979132587 1.29050044109391 0.75 18.1 18 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0325176686267122 0.0625305979132587 1.29050044109391 0.75 18.1 18 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0325176686267122 0.0625305979132587 1.29050044109391 0.75 18.1 18 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0325176686267122 0.0625305979132587 1.29050044109391 0.75 18.1 18 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0325176686267122 0.0625305979132587 1.29050044109391 0.75 18.1 18 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0325176686267122 0.0625305979132587 1.29050044109391 0.75 18.1 18 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0325176686267122 0.0625305979132587 1.29050044109391 0.75 18.1 18 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.70410121423828e-07 1.77324240915257e-06 1.29050044109391 0.75 18.1 18 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.70410121423828e-07 1.77324240915257e-06 1.29050044109391 0.75 18.1 18 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 9.53519889634009e-07 5.74940170741184e-06 1.29050044109391 0.75 18.1 18 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000570599982337062 0.00178062231330184 1.29050044109391 0.75 18.1 18 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000570599982337062 0.00178062231330184 1.29050044109391 0.75 18.1 18 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.25193984993618e-15 3.07156966630893e-14 1.2864801904986 0.747663551401869 18.1 18 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.04701569071632e-14 6.56955049680201e-13 1.28172152652865 0.744897959183674 18.1 18 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.58215084937741e-07 1.06701453017254e-06 1.28134795569608 0.74468085106383 18.1 18 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 5.56137892794473e-07 3.44080096281102e-06 1.28049656170559 0.744186046511628 18.1 18 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 6.95231760994242e-06 3.54593116808174e-05 1.27820996070254 0.742857142857143 18.1 18 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 6.95231760994242e-06 3.54593116808174e-05 1.27820996070254 0.742857142857143 18.1 18 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.17304946723494e-09 1.85164634244031e-08 1.27662409226495 0.741935483870968 18.1 18 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 2.47720090084672e-05 0.000109473816208226 1.27662409226495 0.741935483870968 18.1 18 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.55533766152309e-12 3.71045458402791e-11 1.2753180829634 0.741176470588235 18.1 18 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 8.88873194213125e-05 0.000330252364325138 1.27456833688288 0.740740740740741 18.1 18 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 8.88873194213125e-05 0.000330252364325138 1.27456833688288 0.740740740740741 18.1 18 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 8.88873194213125e-05 0.000330252364325138 1.27456833688288 0.740740740740741 18.1 18 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.66302469200603e-14 7.77982706973817e-13 1.27329376854599 0.74 18.1 18 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000321890280773955 0.00108286021168165 1.27179753615052 0.739130434782609 18.1 18 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 7.42098357091189e-14 1.53044342339241e-12 1.2687748444425 0.737373737373737 18.1 18 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00440635235337004 0.0108107575842165 1.26182265351405 0.733333333333333 18.1 18 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00440635235337004 0.0108107575842165 1.26182265351405 0.733333333333333 18.1 18 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00440635235337004 0.0108107575842165 1.26182265351405 0.733333333333333 18.1 18 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.49443563666307e-09 1.3374728999821e-08 1.25839844007168 0.73134328358209 18.1 18 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.49443563666307e-09 1.3374728999821e-08 1.25839844007168 0.73134328358209 18.1 18 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.49443563666307e-09 1.3374728999821e-08 1.25839844007168 0.73134328358209 18.1 18 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000181229765817384 0.000636765325328734 1.25741068619407 0.730769230769231 18.1 18 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 2.86692024430634e-05 0.000124000836098721 1.25139436712137 0.727272727272727 18.1 18 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 2.86692024430634e-05 0.000124000836098721 1.25139436712137 0.727272727272727 18.1 18 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 2.86692024430634e-05 0.000124000836098721 1.25139436712137 0.727272727272727 18.1 18 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000655924565553532 0.00203350905617141 1.25139436712137 0.727272727272727 18.1 18 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000655924565553532 0.00203350905617141 1.25139436712137 0.727272727272727 18.1 18 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0169125230027771 0.0356541040488174 1.25139436712137 0.727272727272727 18.1 18 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.87683489040271e-33 6.89592006130382e-31 1.24621856321324 0.724264705882353 18.1 18 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000101957097060051 0.000372969020864915 1.24600042588378 0.724137931034483 18.1 18 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.90042321719248e-10 2.86618210976729e-09 1.24521972386255 0.723684210526316 18.1 18 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.96831768300575e-09 4.85309489309554e-08 1.24417478423413 0.723076923076923 18.1 18 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.62485504172035e-05 7.70722908122688e-05 1.2427041284608 0.722222222222222 18.1 18 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.62485504172035e-05 7.70722908122688e-05 1.2427041284608 0.722222222222222 18.1 18 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00240324216325977 0.00628642205573283 1.2427041284608 0.722222222222222 18.1 18 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00240324216325977 0.00628642205573283 1.2427041284608 0.722222222222222 18.1 18 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00240324216325977 0.00628642205573283 1.2427041284608 0.722222222222222 18.1 18 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.000364947665246982 0.0011965910775264 1.23888042345016 0.72 18.1 18 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.80470969326836e-19 1.53503918981572e-17 1.23844203688843 0.719745222929936 18.1 18 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.18288080082877e-08 9.19802939660842e-08 1.23672958938167 0.71875 18.1 18 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.97504880055552e-09 1.69306894168103e-08 1.23597225344206 0.71830985915493 18.1 18 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.49759610998586e-06 8.59306155044307e-06 1.23439172626374 0.717391304347826 18.1 18 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.19940961917706e-19 1.68620736595887e-17 1.23368595626588 0.716981132075472 18.1 18 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 3.22689387611212e-05 0.000138309336918902 1.22904803913706 0.714285714285714 18.1 18 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00131723413079565 0.00372118771013325 1.22904803913706 0.714285714285714 18.1 18 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000203355094431045 0.000709250733763178 1.22904803913706 0.714285714285714 18.1 18 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00896001991886648 0.020432865936774 1.22904803913706 0.714285714285714 18.1 18 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00896001991886648 0.020432865936774 1.22904803913706 0.714285714285714 18.1 18 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.00896001991886648 0.020432865936774 1.22904803913706 0.714285714285714 18.1 18 1 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0681509610367133 0.113759898715217 1.22904803913706 0.714285714285714 18.1 18 1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0681509610367133 0.113759898715217 1.22904803913706 0.714285714285714 18.1 18 1 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.0681509610367133 0.113759898715217 1.22904803913706 0.714285714285714 18.1 18 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0681509610367133 0.113759898715217 1.22904803913706 0.714285714285714 18.1 18 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0681509610367133 0.113759898715217 1.22904803913706 0.714285714285714 18.1 18 1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0681509610367133 0.113759898715217 1.22904803913706 0.714285714285714 18.1 18 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0681509610367133 0.113759898715217 1.22904803913706 0.714285714285714 18.1 18 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0681509610367133 0.113759898715217 1.22904803913706 0.714285714285714 18.1 18 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.60592312603557e-11 3.8872944002641e-10 1.22358560340756 0.711111111111111 18.1 18 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000725054813688202 0.00223807592164493 1.21880597214425 0.708333333333333 18.1 18 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000725054813688202 0.00223807592164493 1.21880597214425 0.708333333333333 18.1 18 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 6.34297572531738e-05 0.00024460852187335 1.21458865044133 0.705882352941177 18.1 18 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00480721654753077 0.0117134745670142 1.21458865044133 0.705882352941177 18.1 18 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00480721654753077 0.0117134745670142 1.21458865044133 0.705882352941177 18.1 18 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00480721654753077 0.0117134745670142 1.21458865044133 0.705882352941177 18.1 18 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00480721654753077 0.0117134745670142 1.21458865044133 0.705882352941177 18.1 18 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.10331613116801e-16 1.55089622404501e-14 1.21313230913385 0.705035971223022 18.1 18 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.51445692506942e-24 1.34692012773362e-22 1.21141147534675 0.704035874439462 18.1 18 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.42064770346338e-17 1.06548083820704e-15 1.21125918593902 0.703947368421053 18.1 18 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000400543076008053 0.00130130775607182 1.21083992003873 0.703703703703704 18.1 18 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 3.55014842845466e-05 0.000151253329751227 1.2091175303943 0.702702702702703 18.1 18 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 3.55014842845466e-05 0.000151253329751227 1.2091175303943 0.702702702702703 18.1 18 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.29927821621541e-15 3.08145483612421e-14 1.20446707835432 0.7 18.1 18 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.29927821621541e-15 3.08145483612421e-14 1.20446707835432 0.7 18.1 18 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.000221957773688442 0.000768481537612294 1.20446707835432 0.7 18.1 18 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.98959559367969e-05 9.07434144168655e-05 1.20446707835432 0.7 18.1 18 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00260302745478504 0.0067103407031868 1.20446707835432 0.7 18.1 18 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00260302745478504 0.0067103407031868 1.20446707835432 0.7 18.1 18 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00260302745478504 0.0067103407031868 1.20446707835432 0.7 18.1 18 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0343061544202627 0.0643231668620775 1.20446707835432 0.7 18.1 18 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0343061544202627 0.0643231668620775 1.20446707835432 0.7 18.1 18 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0343061544202627 0.0643231668620775 1.20446707835432 0.7 18.1 18 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0343061544202627 0.0643231668620775 1.20446707835432 0.7 18.1 18 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0343061544202627 0.0643231668620775 1.20446707835432 0.7 18.1 18 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0343061544202627 0.0643231668620775 1.20446707835432 0.7 18.1 18 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0343061544202627 0.0643231668620775 1.20446707835432 0.7 18.1 18 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0343061544202627 0.0643231668620775 1.20446707835432 0.7 18.1 18 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.78995278254521e-20 4.20091426502688e-18 1.20352682302383 0.699453551912568 18.1 18 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 8.87879751778179e-10 8.31219004460755e-09 1.20239398527626 0.698795180722892 18.1 18 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 1.11635480621377e-05 5.44031811384313e-05 1.20046552659899 0.697674418604651 18.1 18 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.11635480621377e-05 5.44031811384313e-05 1.20046552659899 0.697674418604651 18.1 18 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.78131891560529e-11 3.04447447454333e-10 1.19925293515798 0.696969696969697 18.1 18 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000123323706948082 0.000446538511417609 1.19925293515798 0.696969696969697 18.1 18 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.00141943150219256 0.00395274173702547 1.19698591637696 0.695652173913043 18.1 18 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.30225565830662e-07 2.13595900080469e-06 1.19571792282148 0.694915254237288 18.1 18 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.22837789761337e-42 3.49596349660766e-40 1.19154187831832 0.692488262910798 18.1 18 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000778312938963583 0.00237160452279481 1.19123117639438 0.692307692307692 18.1 18 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000778312938963583 0.00237160452279481 1.19123117639438 0.692307692307692 18.1 18 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000778312938963583 0.00237160452279481 1.19123117639438 0.692307692307692 18.1 18 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000778312938963583 0.00237160452279481 1.19123117639438 0.692307692307692 18.1 18 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000778312938963583 0.00237160452279481 1.19123117639438 0.692307692307692 18.1 18 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0178120531191637 0.0368806305765044 1.19123117639438 0.692307692307692 18.1 18 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0178120531191637 0.0368806305765044 1.19123117639438 0.692307692307692 18.1 18 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0178120531191637 0.0368806305765044 1.19123117639438 0.692307692307692 18.1 18 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0178120531191637 0.0368806305765044 1.19123117639438 0.692307692307692 18.1 18 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0178120531191637 0.0368806305765044 1.19123117639438 0.692307692307692 18.1 18 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0178120531191637 0.0368806305765044 1.19123117639438 0.692307692307692 18.1 18 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.09822511777558e-13 5.51096792824331e-12 1.1890789972139 0.691056910569106 18.1 18 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.09822511777558e-13 5.51096792824331e-12 1.1890789972139 0.691056910569106 18.1 18 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.05739872685797e-18 5.37385138685317e-17 1.18472171641408 0.688524590163934 18.1 18 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.88923352090027e-17 6.2520448842816e-16 1.1842239341803 0.688235294117647 18.1 18 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00942574049797946 0.0212664607213664 1.18295873766942 0.6875 18.1 18 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00942574049797946 0.0212664607213664 1.18295873766942 0.6875 18.1 18 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.56340880296534e-17 1.07887887800419e-15 1.18104971334828 0.686390532544379 18.1 18 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.24047519827524e-25 1.17679747143045e-23 1.18007447742432 0.685823754789272 18.1 18 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.1213977760394e-06 1.19791628385082e-05 1.17897571161666 0.685185185185185 18.1 18 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.58298621229251e-13 6.14287877119546e-12 1.17872481233775 0.68503937007874 18.1 18 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.61984386547139e-08 2.66893151324652e-07 1.17853921561088 0.684931506849315 18.1 18 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 7.30670620687958e-05 0.00027875182124369 1.1772986480155 0.684210526315789 18.1 18 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00505288903150114 0.012003774777673 1.1772986480155 0.684210526315789 18.1 18 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 4.0716696740118e-05 0.000170914039708519 1.1750898325408 0.682926829268293 18.1 18 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 4.0716696740118e-05 0.000170914039708519 1.1750898325408 0.682926829268293 18.1 18 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 4.0716696740118e-05 0.000170914039708519 1.1750898325408 0.682926829268293 18.1 18 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.7344969244801e-28 6.12471738503199e-26 1.17451689746886 0.68259385665529 18.1 18 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 2.27339264926697e-05 0.000102976337113549 1.17318221917628 0.681818181818182 18.1 18 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 7.26345072842213e-16 1.81331410290258e-14 1.17220456732697 0.68125 18.1 18 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.1338392664326e-16 1.06953695929702e-14 1.17174273179079 0.680981595092024 18.1 18 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 6.80317050272136e-08 4.84045581268625e-07 1.17100965951114 0.680555555555556 18.1 18 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 7.12235527861725e-06 3.61968270052584e-05 1.17005373325848 0.68 18.1 18 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00149028250412579 0.00413386355432944 1.17005373325848 0.68 18.1 18 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00149028250412579 0.00413386355432944 1.17005373325848 0.68 18.1 18 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.9717824206987e-11 4.24950855989041e-10 1.1681594206844 0.678899082568807 18.1 18 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.7741923955308e-48 1.34266894471008e-45 1.16782929650324 0.678707224334601 18.1 18 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000816828814892843 0.00244043682182692 1.16759563718021 0.678571428571429 18.1 18 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000816828814892843 0.00244043682182692 1.16759563718021 0.678571428571429 18.1 18 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 5.23978007406177e-21 3.92431949757363e-19 1.16511549539719 0.677130044843049 18.1 18 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000248556510855615 0.00084819164256005 1.16398079000627 0.676470588235294 18.1 18 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000248556510855615 0.00084819164256005 1.16398079000627 0.676470588235294 18.1 18 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 4.26760875802135e-05 0.000177567463820596 1.16045000904569 0.674418604651163 18.1 18 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.91317058890002e-17 9.42145851819258e-16 1.15958010649018 0.673913043478261 18.1 18 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 2.38237493442109e-05 0.000106273339551135 1.15958010649018 0.673913043478261 18.1 18 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 2.38237493442109e-05 0.000106273339551135 1.15958010649018 0.673913043478261 18.1 18 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.46220252302197e-13 2.70222622111722e-12 1.15931481705836 0.673758865248227 18.1 18 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 7.86809305267661e-10 7.41476583705882e-09 1.15284706071056 0.67 18.1 18 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.18228173727677e-19 7.00994546727017e-18 1.14971857479276 0.668181818181818 18.1 18 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 2.46958676005965e-05 0.000109473816208226 1.14711150319459 0.666666666666667 18.1 18 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 2.46958676005965e-05 0.000109473816208226 1.14711150319459 0.666666666666667 18.1 18 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 4.42127562700761e-05 0.000182717573707329 1.14711150319459 0.666666666666667 18.1 18 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 7.93032009215185e-05 0.000298540886008785 1.14711150319459 0.666666666666667 18.1 18 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 7.93032009215185e-05 0.000298540886008785 1.14711150319459 0.666666666666667 18.1 18 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 7.93032009215185e-05 0.000298540886008785 1.14711150319459 0.666666666666667 18.1 18 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00280818487920128 0.00717423174704384 1.14711150319459 0.666666666666667 18.1 18 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00280818487920128 0.00717423174704384 1.14711150319459 0.666666666666667 18.1 18 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00517461410276385 0.0121911852123062 1.14711150319459 0.666666666666667 18.1 18 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00517461410276385 0.0121911852123062 1.14711150319459 0.666666666666667 18.1 18 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0344895125198631 0.0643231668620775 1.14711150319459 0.666666666666667 18.1 18 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.82584066078253e-12 4.06178915181165e-11 1.14711150319459 0.666666666666667 18.1 18 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00046431068832755 0.00149482830201381 1.14711150319459 0.666666666666667 18.1 18 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00046431068832755 0.00149482830201381 1.14711150319459 0.666666666666667 18.1 18 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00046431068832755 0.00149482830201381 1.14711150319459 0.666666666666667 18.1 18 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000842136385056216 0.00249139308926194 1.14711150319459 0.666666666666667 18.1 18 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00153385266487464 0.00422998515914072 1.14711150319459 0.666666666666667 18.1 18 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00153385266487464 0.00422998515914072 1.14711150319459 0.666666666666667 18.1 18 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00153385266487464 0.00422998515914072 1.14711150319459 0.666666666666667 18.1 18 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00961516531607279 0.0215810413955388 1.14711150319459 0.666666666666667 18.1 18 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0180673550498593 0.0368806305765044 1.14711150319459 0.666666666666667 18.1 18 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0180673550498593 0.0368806305765044 1.14711150319459 0.666666666666667 18.1 18 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0180673550498593 0.0368806305765044 1.14711150319459 0.666666666666667 18.1 18 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0180673550498593 0.0368806305765044 1.14711150319459 0.666666666666667 18.1 18 1 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0674379309688324 0.113759898715217 1.14711150319459 0.666666666666667 18.1 18 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 5.33923644121313e-12 7.37644024839445e-11 1.13848660467433 0.661654135338346 18.1 18 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 2.53582304919649e-05 0.000111717529381009 1.13564038816264 0.66 18.1 18 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.46767610627439e-07 9.99283779535144e-07 1.13259110441997 0.658227848101266 18.1 18 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 8.16397017013202e-07 5.00746963452494e-06 1.1307241960061 0.657142857142857 18.1 18 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000473073911263225 0.00149929660518389 1.1307241960061 0.657142857142857 18.1 18 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.79736450129081e-08 3.48298453333512e-07 1.12733371865675 0.655172413793103 18.1 18 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.79736450129081e-08 3.48298453333512e-07 1.12733371865675 0.655172413793103 18.1 18 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00155430400598163 0.00425689400170565 1.12733371865675 0.655172413793103 18.1 18 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 9.19764808861204e-10 8.55441387587904e-09 1.12625493040923 0.654545454545455 18.1 18 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.58223973369415e-05 0.00011306237357067 1.12505166659469 0.653846153846154 18.1 18 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.58223973369415e-05 0.00011306237357067 1.12505166659469 0.653846153846154 18.1 18 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00283511390498777 0.00719138518145738 1.12505166659469 0.653846153846154 18.1 18 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00283511390498777 0.00719138518145738 1.12505166659469 0.653846153846154 18.1 18 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00283511390498777 0.00719138518145738 1.12505166659469 0.653846153846154 18.1 18 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.54407873709016e-11 5.8874806290144e-10 1.12453056809233 0.653543307086614 18.1 18 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.47446685902757e-06 8.56394424651524e-06 1.1221742966034 0.652173913043478 18.1 18 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.47446685902757e-06 8.56394424651524e-06 1.1221742966034 0.652173913043478 18.1 18 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.47446685902757e-06 8.56394424651524e-06 1.1221742966034 0.652173913043478 18.1 18 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 8.24421442560725e-05 0.000308789677614136 1.1221742966034 0.652173913043478 18.1 18 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00519975334529297 0.0122301636534742 1.1221742966034 0.652173913043478 18.1 18 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 4.88601668563667e-08 3.51246465384939e-07 1.12133371660595 0.651685393258427 18.1 18 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 8.6292448797214e-08 5.98995876285052e-07 1.12043449149239 0.651162790697674 18.1 18 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.52462269194595e-07 1.03311337649481e-06 1.11947026215376 0.650602409638554 18.1 18 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 6.01140072719238e-12 8.12616382461503e-11 1.11903534752199 0.65034965034965 18.1 18 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.00960263195968817 0.0215810413955388 1.11843371561472 0.65 18.1 18 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000476760148600367 0.00150762153657405 1.11610848959474 0.648648648648649 18.1 18 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.14210558480639e-12 1.86443160067284e-11 1.11402174829475 0.647435897435897 18.1 18 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0178930344071354 0.0368806305765044 1.11337292957122 0.647058823529412 18.1 18 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0178930344071354 0.0368806305765044 1.11337292957122 0.647058823529412 18.1 18 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.72450228753901e-07 1.77842511704955e-06 1.11213859151183 0.646341463414634 18.1 18 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.98351453041712e-09 2.51215454247548e-08 1.11061250082022 0.645454545454546 18.1 18 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 8.31193918402655e-06 4.10690606210756e-05 1.11010790631734 0.645161290322581 18.1 18 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00155557616365913 0.00425689400170565 1.11010790631734 0.645161290322581 18.1 18 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00155557616365913 0.00425689400170565 1.11010790631734 0.645161290322581 18.1 18 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 9.91969583465943e-28 1.1763105977267e-25 1.10877221498621 0.644385026737968 18.1 18 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.8095984410388e-10 1.86598447941899e-09 1.10709598564129 0.643410852713178 18.1 18 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00282449559484186 0.00719138518145738 1.10614323522335 0.642857142857143 18.1 18 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0337457128796986 0.0643231668620775 1.10614323522335 0.642857142857143 18.1 18 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0337457128796986 0.0643231668620775 1.10614323522335 0.642857142857143 18.1 18 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0337457128796986 0.0643231668620775 1.10614323522335 0.642857142857143 18.1 18 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0337457128796986 0.0643231668620775 1.10614323522335 0.642857142857143 18.1 18 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0337457128796986 0.0643231668620775 1.10614323522335 0.642857142857143 18.1 18 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.87363606073344e-19 1.06647364576947e-17 1.10519781365479 0.642307692307692 18.1 18 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 4.83818125198505e-07 3.01961926384857e-06 1.10462589196516 0.641975308641975 18.1 18 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 8.53777974740692e-07 5.16989811938725e-06 1.1029918299948 0.641025641025641 18.1 18 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00515112243489103 0.0121761581808138 1.10122704306681 0.64 18.1 18 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00515112243489103 0.0121761581808138 1.10122704306681 0.64 18.1 18 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00515112243489103 0.0121761581808138 1.10122704306681 0.64 18.1 18 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.47620845247983e-05 7.04914304657314e-05 1.10009873667022 0.639344262295082 18.1 18 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.66154485263911e-06 1.45668397127133e-05 1.09931519056148 0.638888888888889 18.1 18 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.7244875639284e-09 1.49630841675007e-08 1.09891354087549 0.638655462184874 18.1 18 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.21436890118714e-13 4.03980377742218e-12 1.0985050835677 0.638418079096045 18.1 18 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.53996457073505e-53 7.30456528051993e-51 1.0949700712312 0.636363636363636 18.1 18 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 2.74669607817871e-07 1.78472535125493e-06 1.0949700712312 0.636363636363636 18.1 18 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00154123567113221 0.00424212448746834 1.0949700712312 0.636363636363636 18.1 18 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00944511818405029 0.0212664607213664 1.0949700712312 0.636363636363636 18.1 18 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00944511818405029 0.0212664607213664 1.0949700712312 0.636363636363636 18.1 18 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0647450094008623 0.110735755261331 1.0949700712312 0.636363636363636 18.1 18 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 4.8320764971192e-07 3.01961926384857e-06 1.0931297853972 0.635294117647059 18.1 18 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 4.8320764971192e-07 3.01961926384857e-06 1.0931297853972 0.635294117647059 18.1 18 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 4.8320764971192e-07 3.01961926384857e-06 1.0931297853972 0.635294117647059 18.1 18 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 4.8320764971192e-07 3.01961926384857e-06 1.0931297853972 0.635294117647059 18.1 18 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 4.8320764971192e-07 3.01961926384857e-06 1.0931297853972 0.635294117647059 18.1 18 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.65255019891322e-06 1.45668397127133e-05 1.09285622939485 0.635135135135135 18.1 18 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.65255019891322e-06 1.45668397127133e-05 1.09285622939485 0.635135135135135 18.1 18 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.46944546731335e-05 7.04047441073032e-05 1.09248714589961 0.634920634920635 18.1 18 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.75148374225905e-60 6.22668068261731e-57 1.09196191169485 0.634615384615385 18.1 18 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.8652892734191e-08 2.1459508610923e-07 1.09196191169485 0.634615384615385 18.1 18 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 8.24596468681459e-05 0.000308789677614136 1.09196191169485 0.634615384615385 18.1 18 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 8.50189145702489e-07 5.16989811938725e-06 1.09115484450217 0.634146341463415 18.1 18 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00047172479339452 0.00149835799330447 1.09115484450217 0.634146341463415 18.1 18 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00047172479339452 0.00149835799330447 1.09115484450217 0.634146341463415 18.1 18 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00047172479339452 0.00149835799330447 1.09115484450217 0.634146341463415 18.1 18 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00047172479339452 0.00149835799330447 1.09115484450217 0.634146341463415 18.1 18 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.49609011076913e-06 8.59306155044307e-06 1.08902990809613 0.632911392405063 18.1 18 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.63306657813437e-06 1.45668397127133e-05 1.08673721355277 0.631578947368421 18.1 18 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0174362103753385 0.0365954680886528 1.08673721355277 0.631578947368421 18.1 18 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0174362103753385 0.0365954680886528 1.08673721355277 0.631578947368421 18.1 18 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.61520148309466e-08 1.24239551915876e-07 1.08510547599488 0.630630630630631 18.1 18 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 8.74710901079948e-08 6.04229908852799e-07 1.08402037051889 0.63 18.1 18 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.48229569380183e-06 8.57441777349594e-06 1.08338308635045 0.62962962962963 18.1 18 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00504725801318006 0.012003774777673 1.08338308635045 0.62962962962963 18.1 18 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.96791249577126e-09 2.51215454247548e-08 1.08235520865941 0.629032258064516 18.1 18 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.31892412950317e-14 2.88742928658925e-13 1.08156227444061 0.628571428571429 18.1 18 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 5.1846342391743e-09 4.24007731169255e-08 1.08074968069573 0.628099173553719 18.1 18 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 8.34600626246668e-07 5.09715318089703e-06 1.08041897393909 0.627906976744186 18.1 18 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 4.8873366230652e-08 3.51246465384939e-07 1.07742715954258 0.626168224299065 18.1 18 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 6.46323651555146e-13 1.09490304305116e-11 1.07656721289118 0.625668449197861 18.1 18 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.9586769192089e-34 8.04742465147752e-32 1.07622259007582 0.625468164794007 18.1 18 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000256072432987952 0.000871748976415923 1.07541703424493 0.625 18.1 18 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000827826294192098 0.00245416003465699 1.07541703424493 0.625 18.1 18 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000827826294192098 0.00245416003465699 1.07541703424493 0.625 18.1 18 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000827826294192098 0.00245416003465699 1.07541703424493 0.625 18.1 18 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00272167014811803 0.00697826418157109 1.07541703424493 0.625 18.1 18 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00918570078877914 0.0208140958955935 1.07541703424493 0.625 18.1 18 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00918570078877914 0.0208140958955935 1.07541703424493 0.625 18.1 18 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00918570078877914 0.0208140958955935 1.07541703424493 0.625 18.1 18 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00918570078877914 0.0208140958955935 1.07541703424493 0.625 18.1 18 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0324700459696592 0.0625305979132587 1.07541703424493 0.625 18.1 18 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0324700459696592 0.0625305979132587 1.07541703424493 0.625 18.1 18 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0324700459696592 0.0625305979132587 1.07541703424493 0.625 18.1 18 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.127539781720049 0.201207438345487 1.07541703424493 0.625 18.1 18 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.127539781720049 0.201207438345487 1.07541703424493 0.625 18.1 18 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.127539781720049 0.201207438345487 1.07541703424493 0.625 18.1 18 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.127539781720049 0.201207438345487 1.07541703424493 0.625 18.1 18 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.127539781720049 0.201207438345487 1.07541703424493 0.625 18.1 18 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.76026764037254e-08 2.0782332551588e-07 1.07541703424493 0.625 18.1 18 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.44090633954434e-06 8.47276744285781e-06 1.07288664122317 0.623529411764706 18.1 18 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.44090633954434e-06 8.47276744285781e-06 1.07288664122317 0.623529411764706 18.1 18 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 4.45558665329888e-05 0.000182717573707329 1.0718910767556 0.622950819672131 18.1 18 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.45558665329888e-05 0.000182717573707329 1.0718910767556 0.622950819672131 18.1 18 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.000141600693560664 0.000502488246725249 1.07135885675721 0.622641509433962 18.1 18 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 8.65658074265896e-09 6.76830461362841e-08 1.06847885983044 0.620967741935484 18.1 18 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 8.65658074265896e-09 6.76830461362841e-08 1.06847885983044 0.620967741935484 18.1 18 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 8.65658074265896e-09 6.76830461362841e-08 1.06847885983044 0.620967741935484 18.1 18 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 7.93635091906654e-07 4.88892959213493e-06 1.06606558177323 0.619565217391304 18.1 18 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.64960255472939e-10 1.71341929589776e-09 1.06570359006465 0.619354838709677 18.1 18 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 4.04430943152522e-16 1.065750429826e-14 1.06517496725212 0.619047619047619 18.1 18 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 4.04430943152522e-16 1.065750429826e-14 1.06517496725212 0.619047619047619 18.1 18 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 4.04430943152522e-16 1.065750429826e-14 1.06517496725212 0.619047619047619 18.1 18 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.10603780980127e-13 2.24841686192458e-12 1.06517496725212 0.619047619047619 18.1 18 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 4.35821408277329e-05 0.000180808706699312 1.06517496725212 0.619047619047619 18.1 18 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000806856736612592 0.00242739352262097 1.06517496725212 0.619047619047619 18.1 18 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00264191942545747 0.00678601325347649 1.06276506913616 0.617647058823529 18.1 18 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00264191942545747 0.00678601325347649 1.06276506913616 0.617647058823529 18.1 18 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 7.65522649970032e-05 0.00029126704034956 1.06107814045499 0.616666666666667 18.1 18 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.35076185130985e-05 6.49369633247946e-05 1.06068529404979 0.616438356164384 18.1 18 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.41467006090122e-06 1.34748058692644e-05 1.06041121516244 0.616279069767442 18.1 18 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.94239218804734e-11 9.42594376562323e-10 1.05967922398768 0.615853658536585 18.1 18 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0611734475609821 0.109084982304859 1.05887215679501 0.615384615384615 18.1 18 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0611734475609821 0.109084982304859 1.05887215679501 0.615384615384615 18.1 18 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.37379898053839e-07 9.39863437166408e-07 1.0576578538629 0.614678899082569 18.1 18 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.72100459619738e-08 5.41231011841816e-07 1.05655006873186 0.614035087719298 18.1 18 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.67791790119814e-10 2.6648092121713e-09 1.05635901085325 0.613924050632911 18.1 18 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.32045351967973e-07 1.53581644581594e-06 1.05151887792837 0.611111111111111 18.1 18 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.29399148735031e-05 0.000102976337113549 1.05151887792837 0.611111111111111 18.1 18 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.29399148735031e-05 0.000102976337113549 1.05151887792837 0.611111111111111 18.1 18 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.29399148735031e-05 0.000102976337113549 1.05151887792837 0.611111111111111 18.1 18 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0309011144073765 0.0602360079475298 1.05151887792837 0.611111111111111 18.1 18 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0013842348891883 0.00390052722240585 1.04918735048286 0.609756097560976 18.1 18 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 8.20277513721433e-12 9.119178922075e-11 1.0485316083888 0.609375 18.1 18 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 3.99908906740666e-05 0.000169366182824991 1.04736267682984 0.608695652173913 18.1 18 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0160490190443395 0.0346551655540138 1.04736267682984 0.608695652173913 18.1 18 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.89760053700228e-07 2.50963147699287e-06 1.04526515478012 0.607476635514019 18.1 18 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0084824362960663 0.0194372090971052 1.0446908332665 0.607142857142857 18.1 18 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.26569390911358e-09 1.16953404718742e-08 1.0435014319383 0.606451612903226 18.1 18 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 3.86432030520381e-05 0.000164147098337463 1.04209425290213 0.605633802816901 18.1 18 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00244906124936192 0.00638280981289747 1.0414564963214 0.605263157894737 18.1 18 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00244906124936192 0.00638280981289747 1.0414564963214 0.605263157894737 18.1 18 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000398849539363582 0.00129877092566219 1.03889343685548 0.60377358490566 18.1 18 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 6.32669175819049e-83 9.00288237190506e-80 1.03862097045217 0.603615235635894 18.1 18 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.61878953892048e-08 2.66893151324652e-07 1.03765429869129 0.603053435114504 18.1 18 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.61878953892048e-08 2.66893151324652e-07 1.03765429869129 0.603053435114504 18.1 18 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 6.71403981419029e-05 0.000258218342043048 1.03746113891864 0.602941176470588 18.1 18 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 6.42770006150624e-06 3.3020278655319e-05 1.03631096027238 0.602272727272727 18.1 18 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.08080339409167e-06 6.46211441089263e-06 1.03240035287513 0.6 18.1 18 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000382782857236211 0.00124931194001635 1.03240035287513 0.6 18.1 18 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.000382782857236211 0.00124931194001635 1.03240035287513 0.6 18.1 18 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00433316689847572 0.0106864757305562 1.03240035287513 0.6 18.1 18 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.45551055630647e-06 1.81446181609745e-05 1.03240035287513 0.6 18.1 18 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.45551055630647e-06 1.81446181609745e-05 1.03240035287513 0.6 18.1 18 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0080808597328901 0.0186370557534888 1.03240035287513 0.6 18.1 18 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0291865779988139 0.0570501380388903 1.03240035287513 0.6 18.1 18 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0291865779988139 0.0570501380388903 1.03240035287513 0.6 18.1 18 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0572632496244575 0.102368849517089 1.03240035287513 0.6 18.1 18 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0572632496244575 0.102368849517089 1.03240035287513 0.6 18.1 18 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0572632496244575 0.102368849517089 1.03240035287513 0.6 18.1 18 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.117135595791687 0.186447374509586 1.03240035287513 0.6 18.1 18 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.83126074913594e-07 1.2234197399157e-06 1.02957958688367 0.598360655737705 18.1 18 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.06605252894337e-05 5.231009478229e-05 1.02844479596756 0.597701149425287 18.1 18 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.000111730283654051 0.000407672291383884 1.02726403271157 0.597014925373134 18.1 18 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000202052581302973 0.000706439369027348 1.02684981334354 0.596774193548387 18.1 18 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.83419471386458e-05 8.44679313213364e-05 1.02420669928088 0.595238095238095 18.1 18 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.83419471386458e-05 8.44679313213364e-05 1.02420669928088 0.595238095238095 18.1 18 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.00019313684906456 0.00067693038477554 1.02164618253268 0.59375 18.1 18 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 3.15149444334051e-05 0.000135485697669895 1.0196546695063 0.592592592592593 18.1 18 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 8.37433344294939e-09 6.69476207264999e-08 1.01924875602322 0.592356687898089 18.1 18 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0274192227895034 0.0544937905439432 1.01675792328611 0.590909090909091 18.1 18 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0039084996690626 0.00968953837818133 1.01475248359521 0.58974358974359 18.1 18 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 8.940128923455e-06 4.40200811698148e-05 1.01428806598258 0.589473684210526 18.1 18 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000604814873357963 0.00188326381791768 1.01396463228807 0.589285714285714 18.1 18 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00110101169436415 0.00314606353630558 1.01215720870111 0.588235294117647 18.1 18 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0532943482018361 0.0957548705697131 1.01215720870111 0.588235294117647 18.1 18 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0532943482018361 0.0957548705697131 1.01215720870111 0.588235294117647 18.1 18 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00201232375787604 0.00540275808265533 1.00995686694306 0.58695652173913 18.1 18 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0135533172425644 0.0298089187576029 1.00866701142973 0.586206896551724 18.1 18 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0135533172425644 0.0298089187576029 1.00866701142973 0.586206896551724 18.1 18 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0135533172425644 0.0298089187576029 1.00866701142973 0.586206896551724 18.1 18 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.000166760645847669 0.000587377225349588 1.00781939209239 0.585714285714286 18.1 18 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0036959717010101 0.00924317703082138 1.00721985646354 0.585365853658537 18.1 18 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0036959717010101 0.00924317703082138 1.00721985646354 0.585365853658537 18.1 18 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.90135455105783e-26 1.93259109011092e-24 1.00648487408142 0.584938704028021 18.1 18 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000300941507060054 0.00101478617191103 1.00592854895526 0.584615384615385 18.1 18 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00190345507073213 0.00513968987789718 1.00372256529527 0.583333333333333 18.1 18 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.107102705034261 0.174378889317796 1.00372256529527 0.583333333333333 18.1 18 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00682988913364434 0.0158288798651073 1.00372256529527 0.583333333333333 18.1 18 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000987430469524349 0.00286173840760315 1.0011154936971 0.581818181818182 18.1 18 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000987430469524349 0.00286173840760315 1.0011154936971 0.581818181818182 18.1 18 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000987430469524349 0.00286173840760315 1.0011154936971 0.581818181818182 18.1 18 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0127204175110172 0.0281073821710831 0.99909711568561 0.580645161290323 18.1 18 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 4.60995160535077e-15 1.04126367212923e-13 0.997564758146215 0.579754601226994 18.1 18 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000141996648937243 0.000502639879198249 0.996175779090038 0.578947368421053 18.1 18 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0494153574514288 0.0894304528905017 0.996175779090038 0.578947368421053 18.1 18 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0494153574514288 0.0894304528905017 0.996175779090038 0.578947368421053 18.1 18 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0239387031880772 0.0476430414498376 0.992692646995318 0.576923076923077 18.1 18 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000879599186668439 0.00259682498470786 0.991570960388543 0.576271186440678 18.1 18 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 2.90082390944512e-27 3.17528647933877e-25 0.990119571186621 0.575427682737169 18.1 18 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00159361071488665 0.00435260661666739 0.98779046108423 0.574074074074074 18.1 18 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00564617342544756 0.0132582587201516 0.983238431309648 0.571428571428571 18.1 18 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0457044673609788 0.0842454106925814 0.983238431309648 0.571428571428571 18.1 18 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0457044673609788 0.0842454106925814 0.983238431309648 0.571428571428571 18.1 18 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0457044673609788 0.0842454106925814 0.983238431309648 0.571428571428571 18.1 18 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000407562109751882 0.00132109540359209 0.983238431309648 0.571428571428571 18.1 18 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00289601220757947 0.00731976087279855 0.983238431309648 0.571428571428571 18.1 18 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00289601220757947 0.00731976087279855 0.983238431309648 0.571428571428571 18.1 18 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0111298107917707 0.0248629839194501 0.983238431309648 0.571428571428571 18.1 18 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.022284940155578 0.0446012234056082 0.983238431309648 0.571428571428571 18.1 18 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0977437604693603 0.160056813749022 0.983238431309648 0.571428571428571 18.1 18 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0977437604693603 0.160056813749022 0.983238431309648 0.571428571428571 18.1 18 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0977437604693603 0.160056813749022 0.983238431309648 0.571428571428571 18.1 18 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0977437604693603 0.160056813749022 0.983238431309648 0.571428571428571 18.1 18 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 4.70943746350487e-12 6.63517773323508e-11 0.981463632697176 0.570397111913357 18.1 18 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 2.97307888051362e-05 0.000128202765059724 0.980780335231374 0.57 18.1 18 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.32262537659616e-39 3.13682651816056e-37 0.980039707684266 0.56956956956957 18.1 18 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 5.01009450584505e-20 3.24062021900796e-18 0.979241527117332 0.569105691056911 18.1 18 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00140566298152554 0.00392207533864873 0.979000334622968 0.568965517241379 18.1 18 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00140566298152554 0.00392207533864873 0.979000334622968 0.568965517241379 18.1 18 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00140566298152554 0.00392207533864873 0.979000334622968 0.568965517241379 18.1 18 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00140566298152554 0.00392207533864873 0.979000334622968 0.568965517241379 18.1 18 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00140566298152554 0.00392207533864873 0.979000334622968 0.568965517241379 18.1 18 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.27127687501155e-08 9.83166844098608e-08 0.976837139439143 0.567708333333333 18.1 18 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00131797512713082 0.00372118771013325 0.975044777715401 0.566666666666667 18.1 18 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00237659353181295 0.00626276406624043 0.969830634519062 0.563636363636364 18.1 18 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00237659353181295 0.00626276406624043 0.969830634519062 0.563636363636364 18.1 18 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00237659353181295 0.00626276406624043 0.969830634519062 0.563636363636364 18.1 18 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0192197016747018 0.0387388604576497 0.967875330820435 0.5625 18.1 18 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0891402257520554 0.146813126441175 0.967875330820435 0.5625 18.1 18 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0891402257520554 0.146813126441175 0.967875330820435 0.5625 18.1 18 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0891402257520554 0.146813126441175 0.967875330820435 0.5625 18.1 18 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0891402257520554 0.146813126441175 0.967875330820435 0.5625 18.1 18 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0178180515294527 0.0368806305765044 0.961549348266053 0.558823529411765 18.1 18 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0178180515294527 0.0368806305765044 0.961549348266053 0.558823529411765 18.1 18 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00400148974135487 0.00990281722077909 0.959602892095474 0.557692307692308 18.1 18 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000943120863458859 0.00275012497684827 0.958657470526907 0.557142857142857 18.1 18 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 8.93537557365622e-18 3.02739034316971e-16 0.955926252662158 0.555555555555556 18.1 18 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00372558499009319 0.00930089024719756 0.955926252662158 0.555555555555556 18.1 18 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0165047128644287 0.0354028433443106 0.955926252662158 0.555555555555556 18.1 18 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0165047128644287 0.0354028433443106 0.955926252662158 0.555555555555556 18.1 18 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0812858904449106 0.134656370317937 0.955926252662158 0.555555555555556 18.1 18 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.202667095159069 0.290428274331677 0.955926252662158 0.555555555555556 18.1 18 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.202667095159069 0.290428274331677 0.955926252662158 0.555555555555556 18.1 18 1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.202667095159069 0.290428274331677 0.955926252662158 0.555555555555556 18.1 18 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.202667095159069 0.290428274331677 0.955926252662158 0.555555555555556 18.1 18 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.202667095159069 0.290428274331677 0.955926252662158 0.555555555555556 18.1 18 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.202667095159069 0.290428274331677 0.955926252662158 0.555555555555556 18.1 18 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.202667095159069 0.290428274331677 0.955926252662158 0.555555555555556 18.1 18 1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.202667095159069 0.290428274331677 0.955926252662158 0.555555555555556 18.1 18 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 4.91529373309762e-05 0.000193217209452981 0.954188204930045 0.554545454545455 18.1 18 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000765782560605768 0.00235867658818616 0.950895061858673 0.552631578947368 18.1 18 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0741394212268472 0.123248126642294 0.946366990135536 0.55 18.1 18 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0304107675077858 0.0593614844493542 0.943591720369743 0.548387096774194 18.1 18 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00576606108387455 0.0135174710417685 0.941497177150276 0.547169811320755 18.1 18 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00258595785547558 0.00670276507894672 0.940989904964312 0.546875 18.1 18 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00240099253410401 0.00628642205573283 0.938545775341028 0.545454545454545 18.1 18 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0676467608467492 0.113759898715217 0.938545775341027 0.545454545454545 18.1 18 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.180004299460676 0.260046820439129 0.938545775341027 0.545454545454545 18.1 18 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.180004299460676 0.260046820439129 0.938545775341027 0.545454545454545 18.1 18 1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.180004299460676 0.260046820439129 0.938545775341027 0.545454545454545 18.1 18 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.180004299460676 0.260046820439129 0.938545775341027 0.545454545454545 18.1 18 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000941649265934923 0.00275012497684827 0.934683447047443 0.54320987654321 18.1 18 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0103190671683943 0.0230881015418633 0.932028096345604 0.541666666666667 18.1 18 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0103190671683943 0.0230881015418633 0.932028096345604 0.541666666666667 18.1 18 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0617510967245077 0.109977234842271 0.932028096345604 0.541666666666667 18.1 18 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 6.06960044474376e-14 1.2701531518927e-12 0.929777597320278 0.540358744394619 18.1 18 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.160686838753087 0.234761161751173 0.92651313719563 0.538461538461538 18.1 18 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.160686838753087 0.234761161751173 0.92651313719563 0.538461538461538 18.1 18 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.000559677025276725 0.00176589890680439 0.923726631519853 0.536842105263158 18.1 18 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.03435844519439e-07 7.11058969812375e-07 0.923104750424831 0.536480686695279 18.1 18 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 4.67765278634949e-08 3.43108243039965e-07 0.917689202555671 0.533333333333333 18.1 18 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0430939754519475 0.0798473008699496 0.914104479108188 0.53125 18.1 18 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0144052049246352 0.0315849100273589 0.91300711478753 0.530612244897959 18.1 18 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0394359190370865 0.073164684210918 0.910941487830997 0.529411764705882 18.1 18 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.129466837996052 0.20334581729402 0.910941487830997 0.529411764705882 18.1 18 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.129466837996052 0.20334581729402 0.910941487830997 0.529411764705882 18.1 18 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.129466837996052 0.20334581729402 0.910941487830997 0.529411764705882 18.1 18 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0112434179590574 0.0250774040058599 0.907260916162993 0.527272727272727 18.1 18 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.116697593771002 0.186447374509586 0.905614344627307 0.526315789473684 18.1 18 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.116697593771002 0.186447374509586 0.905614344627307 0.526315789473684 18.1 18 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.116697593771002 0.186447374509586 0.905614344627307 0.526315789473684 18.1 18 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0233667519542258 0.0467006854366059 0.897739437282722 0.521739130434783 18.1 18 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0214426610795497 0.0429759249523933 0.896180861870773 0.520833333333333 18.1 18 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0864852124069589 0.143102857273375 0.89474697249178 0.52 18.1 18 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000326216168425938 0.00109482454639177 0.894205030049325 0.519685039370079 18.1 18 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0785092326776899 0.130360137806713 0.892197835818014 0.518518518518518 18.1 18 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0713579500444219 0.118762997559313 0.890000304202699 0.517241379310345 18.1 18 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0649303183671351 0.110919379395478 0.888086325053876 0.516129032258065 18.1 18 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0449173563242098 0.0831175527299747 0.882393463995838 0.512820512820513 18.1 18 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 7.76757556043459e-05 0.000294753600599958 0.880341386172592 0.511627906976744 18.1 18 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0343271239738398 0.0643231668620775 0.879452152449185 0.511111111111111 18.1 18 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00317096080005425 0.00795816087914849 0.8786385981916 0.51063829787234 18.1 18 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00102807745173791 0.00294356984672646 0.874437457353253 0.508196721311475 18.1 18 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0171209633219073 0.0360401343299913 0.874437457353253 0.508196721311475 18.1 18 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.00802396702735819 0.0185358848700174 0.871223926476903 0.506329113924051 18.1 18 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 7.17895444596882e-05 0.000274614305822947 0.864700803169525 0.50253807106599 18.1 18 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00688315534416852 0.0159263903329298 0.860333627395942 0.5 18.1 18 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0346500290590489 0.0645379467945375 0.860333627395942 0.5 18.1 18 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.252905893887091 0.35421760531627 0.860333627395942 0.5 18.1 18 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.252905893887091 0.35421760531627 0.860333627395942 0.5 18.1 18 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.252905893887091 0.35421760531627 0.860333627395942 0.5 18.1 18 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.252905893887091 0.35421760531627 0.860333627395942 0.5 18.1 18 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.252905893887091 0.35421760531627 0.860333627395942 0.5 18.1 18 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0378633401707381 0.0703388160090866 0.860333627395942 0.5 18.1 18 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0956021241007276 0.157273783347209 0.860333627395942 0.5 18.1 18 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.105484513796903 0.172138145794716 0.860333627395942 0.5 18.1 18 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.159255766315156 0.233149131138341 0.860333627395942 0.5 18.1 18 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.159255766315156 0.233149131138341 0.860333627395942 0.5 18.1 18 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.159255766315156 0.233149131138341 0.860333627395942 0.5 18.1 18 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.223629917036814 0.317907464478907 0.860333627395942 0.5 18.1 18 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.223629917036814 0.317907464478907 0.860333627395942 0.5 18.1 18 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.223629917036814 0.317907464478907 0.860333627395942 0.5 18.1 18 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.223629917036814 0.317907464478907 0.860333627395942 0.5 18.1 18 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.223629917036814 0.317907464478907 0.860333627395942 0.5 18.1 18 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.223629917036814 0.317907464478907 0.860333627395942 0.5 18.1 18 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.288198594526451 0.393954466869491 0.860333627395942 0.5 18.1 18 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.288198594526451 0.393954466869491 0.860333627395942 0.5 18.1 18 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.288198594526451 0.393954466869491 0.860333627395942 0.5 18.1 18 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.288198594526451 0.393954466869491 0.860333627395942 0.5 18.1 18 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.288198594526451 0.393954466869491 0.860333627395942 0.5 18.1 18 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0641597297143797 0.110735755261331 0.841215102342699 0.488888888888889 18.1 18 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.112767555792008 0.18339226501946 0.834262911414247 0.484848484848485 18.1 18 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.124356941975971 0.197279741841479 0.832580929738008 0.483870967741935 18.1 18 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.124356941975971 0.197279741841479 0.832580929738008 0.483870967741935 18.1 18 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0196953841596419 0.0395854966937435 0.829968911134909 0.482352941176471 18.1 18 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0196953841596419 0.0395854966937435 0.829968911134909 0.482352941176471 18.1 18 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0568411804899031 0.10199873876057 0.82846941897387 0.481481481481481 18.1 18 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.151918120289922 0.223325914434462 0.82846941897387 0.481481481481481 18.1 18 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0679648028577433 0.113759898715217 0.825920282300104 0.48 18.1 18 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.168362816376738 0.244719394999079 0.825920282300104 0.48 18.1 18 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.168362816376738 0.244719394999079 0.825920282300104 0.48 18.1 18 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.168362816376738 0.244719394999079 0.825920282300104 0.48 18.1 18 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.168362816376738 0.244719394999079 0.825920282300104 0.48 18.1 18 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00163384160729846 0.00445393986050903 0.818479559036139 0.475675675675676 18.1 18 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0236065550193317 0.0471137837202089 0.814079131299386 0.473118279569892 18.1 18 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0710863151968662 0.11844944557979 0.813406338628891 0.472727272727273 18.1 18 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00414205849324715 0.0102328979789769 0.812240443255796 0.472049689440994 18.1 18 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.2605695896706 0.361282725670095 0.809725766960887 0.470588235294118 18.1 18 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.2605695896706 0.361282725670095 0.809725766960887 0.470588235294118 18.1 18 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00502829346815829 0.0119853628227626 0.807226613359155 0.469135802469136 18.1 18 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.157524836705662 0.231329042964042 0.806562775683696 0.46875 18.1 18 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.173853091347897 0.252184453606583 0.802978052236212 0.466666666666667 18.1 18 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.173853091347897 0.252184453606583 0.802978052236212 0.466666666666667 18.1 18 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.293299793188433 0.400542807780365 0.802978052236212 0.466666666666667 18.1 18 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0368851100668294 0.0686111263073179 0.801674516437128 0.465909090909091 18.1 18 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.146653896673687 0.21603363868184 0.794154117596254 0.461538461538462 18.1 18 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.146653896673687 0.21603363868184 0.794154117596254 0.461538461538462 18.1 18 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.212754001560962 0.304576402637071 0.794154117596254 0.461538461538462 18.1 18 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.331950798287666 0.436571109590661 0.794154117596254 0.461538461538462 18.1 18 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.161063281458348 0.235069794374594 0.790576846796271 0.459459459459459 18.1 18 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00208336742078382 0.00557261624017929 0.787775369663754 0.457831325301205 18.1 18 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.106487812386824 0.173576353982189 0.784865765343666 0.456140350877193 18.1 18 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.378360507081265 0.482443549799857 0.782121479450856 0.454545454545455 18.1 18 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.378360507081265 0.482443549799857 0.782121479450856 0.454545454545455 18.1 18 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.378360507081265 0.482443549799857 0.782121479450856 0.454545454545455 18.1 18 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.378360507081265 0.482443549799857 0.782121479450856 0.454545454545455 18.1 18 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.378360507081265 0.482443549799857 0.782121479450856 0.454545454545455 18.1 18 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.378360507081265 0.482443549799857 0.782121479450856 0.454545454545455 18.1 18 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.378360507081265 0.482443549799857 0.782121479450856 0.454545454545455 18.1 18 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0142536146270817 0.0313007617505204 0.781161821193861 0.45398773006135 18.1 18 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0165196682927774 0.0354028433443106 0.779170077641608 0.452830188679245 18.1 18 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0165196682927774 0.0354028433443106 0.779170077641608 0.452830188679245 18.1 18 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0191408043552884 0.0386345597128729 0.777075534422141 0.451612903225806 18.1 18 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.128493378763 0.202487351029622 0.764741002129726 0.444444444444444 18.1 18 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.326907032969326 0.43337270549107 0.764741002129726 0.444444444444444 18.1 18 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.326907032969326 0.43337270549107 0.764741002129726 0.444444444444444 18.1 18 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.326907032969326 0.43337270549107 0.764741002129726 0.444444444444444 18.1 18 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.139477992536789 0.209364117489294 0.761606817694768 0.442622950819672 18.1 18 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.213994770522651 0.30604478236556 0.755414892347656 0.439024390243902 18.1 18 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.151164323194323 0.22244760279785 0.752791923971449 0.4375 18.1 18 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.366741939021092 0.471626201207834 0.752791923971449 0.4375 18.1 18 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.366741939021092 0.471626201207834 0.752791923971449 0.4375 18.1 18 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.366741939021092 0.471626201207834 0.752791923971449 0.4375 18.1 18 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.366741939021092 0.471626201207834 0.752791923971449 0.4375 18.1 18 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.255798814367175 0.357917121774326 0.74407232639649 0.432432432432432 18.1 18 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0206400728510204 0.0414257033385078 0.742248619714146 0.431372549019608 18.1 18 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0798525311218914 0.132436074343183 0.737428823482236 0.428571428571429 18.1 18 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.313369302073235 0.416751884906742 0.737428823482236 0.428571428571429 18.1 18 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.413191459225806 0.519409405016185 0.737428823482236 0.428571428571429 18.1 18 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.413191459225806 0.519409405016185 0.737428823482236 0.428571428571429 18.1 18 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.413191459225806 0.519409405016185 0.737428823482236 0.428571428571429 18.1 18 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0681919842614755 0.113759898715217 0.734431145337999 0.426829268292683 18.1 18 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.306319540315954 0.407757442347616 0.729980047487466 0.424242424242424 18.1 18 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.306319540315954 0.407757442347616 0.729980047487466 0.424242424242424 18.1 18 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.103018208479572 0.168306441637694 0.728457669911892 0.423357664233577 18.1 18 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.345180696268023 0.453129271945938 0.727974607796566 0.423076923076923 18.1 18 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.101979130512679 0.166800347953497 0.72704250202474 0.422535211267606 18.1 18 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.395564541931915 0.499457269892737 0.724491475701846 0.421052631578947 18.1 18 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.335436448981008 0.440744290766367 0.721570139106274 0.419354838709677 18.1 18 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.123384428662576 0.196174348588654 0.72116201119954 0.419117647058824 18.1 18 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.380617941431127 0.484887493873316 0.716944689496618 0.416666666666667 18.1 18 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.467970945077103 0.57077997739134 0.716944689496618 0.416666666666667 18.1 18 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.467970945077103 0.57077997739134 0.716944689496618 0.416666666666667 18.1 18 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.137895360542966 0.207207072917255 0.715898054913412 0.416058394160584 18.1 18 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.367484876534823 0.471626201207834 0.712000243362159 0.413793103448276 18.1 18 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.420153124510718 0.527694524429613 0.703909331505771 0.409090909090909 18.1 18 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.402764314180056 0.508097180033882 0.701012585285582 0.407407407407407 18.1 18 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.387722895981238 0.491162244094266 0.699021072259203 0.40625 18.1 18 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.293922042708411 0.401007734203326 0.698241784553228 0.405797101449275 18.1 18 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.351298586339853 0.46031113108804 0.695588890235017 0.404255319148936 18.1 18 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.422628638928356 0.530335584828087 0.688266901916754 0.4 18.1 18 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.493119236584053 0.600777974023209 0.688266901916754 0.4 18.1 18 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.464319250730228 0.57077997739134 0.688266901916753 0.4 18.1 18 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.464319250730228 0.57077997739134 0.688266901916753 0.4 18.1 18 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.407902934902161 0.51412389403523 0.680263798406094 0.395348837209302 18.1 18 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.327085232394525 0.43337270549107 0.677838615524075 0.393939393939394 18.1 18 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.440635077163674 0.548577178306131 0.677838615524075 0.393939393939394 18.1 18 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.383145653267104 0.487671077458935 0.676983837950905 0.39344262295082 18.1 18 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.460608145543294 0.57077997739134 0.675976421525383 0.392857142857143 18.1 18 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.345643852492716 0.453319080273857 0.67407583177414 0.391752577319588 18.1 18 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.423052309560632 0.53039950352844 0.673304577962042 0.391304347826087 18.1 18 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.513707024855505 0.621602973103217 0.66914837686351 0.388888888888889 18.1 18 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0238433884443842 0.0475198063814548 0.668122504787483 0.388292682926829 18.1 18 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.5529835368205 0.662370010854859 0.661795097996878 0.384615384615385 18.1 18 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.5529835368205 0.662370010854859 0.661795097996878 0.384615384615385 18.1 18 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.5529835368205 0.662370010854859 0.661795097996878 0.384615384615385 18.1 18 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.5529835368205 0.662370010854859 0.661795097996878 0.384615384615385 18.1 18 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.5529835368205 0.662370010854859 0.661795097996878 0.384615384615385 18.1 18 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.568945615121831 0.680344210351567 0.645250220546956 0.375 18.1 18 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.572452066837306 0.683962461049108 0.630911326757024 0.366666666666667 18.1 18 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.554140359869818 0.663197419760093 0.630103501754774 0.366197183098592 18.1 18 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.549886911287066 0.661444695487316 0.629061146913162 0.365591397849462 18.1 18 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.594685022483211 0.702742480324797 0.625697183560685 0.363636363636364 18.1 18 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.605534042711541 0.702834374207605 0.619440211725078 0.36 18.1 18 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.605428436914993 0.702834374207605 0.61684297813294 0.358490566037736 18.1 18 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.630645802150885 0.724301030234633 0.61452401956853 0.357142857142857 18.1 18 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.630645802150885 0.724301030234633 0.61452401956853 0.357142857142857 18.1 18 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.630645802150885 0.724301030234633 0.61452401956853 0.357142857142857 18.1 18 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.630645802150885 0.724301030234633 0.61452401956853 0.357142857142857 18.1 18 1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.630645802150885 0.724301030234633 0.61452401956853 0.357142857142857 18.1 18 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.63435526710076 0.727973826680953 0.612160465647113 0.355769230769231 18.1 18 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.660424463386504 0.75727962240048 0.595615588197191 0.346153846153846 18.1 18 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.679207102413114 0.778189779978954 0.589943058785789 0.342857142857143 18.1 18 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.703879181437072 0.800655535719387 0.573555751597295 0.333333333333333 18.1 18 1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.699409084934301 0.798122797002013 0.573555751597295 0.333333333333333 18.1 18 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.699409084934301 0.798122797002013 0.573555751597295 0.333333333333333 18.1 18 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.70119648152759 0.799521308664872 0.573555751597295 0.333333333333333 18.1 18 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.714228152426917 0.806624334050399 0.573555751597295 0.333333333333333 18.1 18 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.769687660641494 0.857015290369989 0.561850532176942 0.326530612244898 18.1 18 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.794970534551647 0.881030428868375 0.540781137220306 0.314285714285714 18.1 18 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.799147128814207 0.884969933309429 0.523681338414921 0.304347826086957 18.1 18 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.903527613711977 0.971821462065112 0.522734355886142 0.30379746835443 18.1 18 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.808715106351604 0.894869048474598 0.506078604350554 0.294117647058824 18.1 18 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.837059354242649 0.918096230153603 0.501861282647633 0.291666666666667 18.1 18 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.894361501003349 0.967866941619649 0.501861282647633 0.291666666666667 18.1 18 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.860416294167152 0.937121556096563 0.499548557842805 0.290322580645161 18.1 18 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.924538995073116 0.992919992444562 0.486981298526005 0.283018867924528 18.1 18 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999602289281307 1 0.473183495067768 0.275 18.1 18 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999970061480436 1 0.470079198474071 0.27319587628866 18.1 18 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999346154261189 1 0.4599018469029 0.267281105990783 18.1 18 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.912095928252316 0.980296454609551 0.458844601277836 0.266666666666667 18.1 18 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.936875463063002 1 0.452807172313654 0.263157894736842 18.1 18 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.993703930440449 1 0.446098917909007 0.259259259259259 18.1 18 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.986382921658183 1 0.39431957922314 0.229166666666667 18.1 18 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.948545494575024 1 0.391060739725428 0.227272727272727 18.1 18 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.948545494575024 1 0.391060739725428 0.227272727272727 18.1 18 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.970002158959898 1 0.388537767211071 0.225806451612903 18.1 18 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.970002158959898 1 0.388537767211071 0.225806451612903 18.1 18 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.974183704096117 1 0.368714411741118 0.214285714285714 18.1 18 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999555555262027 1 0.36325197601162 0.211111111111111 18.1 18 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.98682526885907 1 0.354255023045388 0.205882352941176 18.1 18 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99999912553893 1 0.351954665752885 0.204545454545455 18.1 18 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.346733955625569 0.201511335012594 18.1 18 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.978703330148797 1 0.344133450958377 0.2 18.1 18 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.290926561162823 0.169077757685353 18.1 18 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999989478786492 1 0.183049707956583 0.106382978723404 18.1 18 1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.000349977389437027 0.00234914068475891 3.91011723838472 1 19.1 19 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000411662485233621 0.00269951943081771 3.35152906147261 0.857142857142857 19.1 19 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00174368580885406 0.00899009023912801 3.25843103198726 0.833333333333333 19.1 19 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 5.54240698589394e-11 3.58492960951231e-09 2.99775654942828 0.766666666666667 19.1 19 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 7.2102843733926e-05 0.000600013723002203 2.93258792878854 0.75 19.1 19 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 7.2102843733926e-05 0.000600013723002203 2.93258792878854 0.75 19.1 19 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00136065595729673 0.00717116084160462 2.93258792878854 0.75 19.1 19 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00136065595729673 0.00717116084160462 2.93258792878854 0.75 19.1 19 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 5.4095313015348e-05 0.000469375795249025 2.79294088456051 0.714285714285714 19.1 19 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00507374411790518 0.0229204377135844 2.79294088456051 0.714285714285714 19.1 19 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 1.10923505072162e-05 0.000123963576258351 2.76008275650686 0.705882352941177 19.1 19 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000968237320154832 0.00548924982701325 2.7370820668693 0.7 19.1 19 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.000968237320154832 0.00548924982701325 2.7370820668693 0.7 19.1 19 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.000968237320154832 0.00548924982701325 2.7370820668693 0.7 19.1 19 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000968237320154832 0.00548924982701325 2.7370820668693 0.7 19.1 19 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.000191724129816533 0.0013848905417712 2.70700424195865 0.692307692307692 19.1 19 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000191724129816533 0.0013848905417712 2.70700424195865 0.692307692307692 19.1 19 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 3.88192199479336e-05 0.000358699675233179 2.68820560138949 0.6875 19.1 19 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 3.88192199479336e-05 0.000358699675233179 2.68820560138949 0.6875 19.1 19 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 3.46932278866786e-07 8.51180401426615e-06 2.65887972210161 0.68 19.1 19 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000659930267822227 0.00394972398034608 2.60674482558981 0.666666666666667 19.1 19 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000659930267822227 0.00394972398034608 2.60674482558981 0.666666666666667 19.1 19 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 2.70743948826902e-05 0.000260316648095055 2.60674482558981 0.666666666666667 19.1 19 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0033762364629256 0.0163414438324596 2.60674482558981 0.666666666666667 19.1 19 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000439456000058667 0.00282292297454465 2.51364679610446 0.642857142857143 19.1 19 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00219357332317324 0.011148052995984 2.48825642442664 0.636363636363636 19.1 19 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 5.98113847861593e-05 0.000512720485245209 2.46954772950614 0.631578947368421 19.1 19 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 8.16429397036393e-12 5.53228110467994e-10 2.44382327399045 0.625 19.1 19 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00028865710898872 0.00195599555281404 2.44382327399045 0.625 19.1 19 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0112622243855859 0.042622726863534 2.44382327399045 0.625 19.1 19 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0112622243855859 0.042622726863534 2.44382327399045 0.625 19.1 19 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0112622243855859 0.042622726863534 2.44382327399045 0.625 19.1 19 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.0112622243855859 0.042622726863534 2.44382327399045 0.625 19.1 19 1 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.0112622243855859 0.042622726863534 2.44382327399045 0.625 19.1 19 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0112622243855859 0.042622726863534 2.44382327399045 0.625 19.1 19 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0112622243855859 0.042622726863534 2.44382327399045 0.625 19.1 19 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0112622243855859 0.042622726863534 2.44382327399045 0.625 19.1 19 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 3.95204089498121e-05 0.000362822851197307 2.42054876661911 0.619047619047619 19.1 19 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00140906008863133 0.00739886533624497 2.40622599285213 0.615384615384615 19.1 19 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.13377291972043e-07 2.93337975411305e-06 2.38951609012399 0.611111111111111 19.1 19 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 2.59348426837458e-05 0.00025105633427871 2.38007136249504 0.608695652173913 19.1 19 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.59348426837458e-05 0.00025105633427871 2.38007136249504 0.608695652173913 19.1 19 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000121745656438368 0.00095189048962526 2.34607034303083 0.6 19.1 19 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00698823517708174 0.0300430775135568 2.34607034303083 0.6 19.1 19 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00698823517708174 0.0300430775135568 2.34607034303083 0.6 19.1 19 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.00698823517708174 0.0300430775135568 2.34607034303083 0.6 19.1 19 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.00698823517708174 0.0300430775135568 2.34607034303083 0.6 19.1 19 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.69346309157974e-05 0.000173366761102012 2.34607034303083 0.6 19.1 19 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 7.85509050071912e-05 0.000638731073287046 2.31052382268188 0.590909090909091 19.1 19 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.000572950387654633 0.00359166696754424 2.30006896375572 0.588235294117647 19.1 19 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00434067360066467 0.0204529090521385 2.28090172239108 0.583333333333333 19.1 19 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00434067360066467 0.0204529090521385 2.28090172239108 0.583333333333333 19.1 19 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.10414816392852e-08 1.26960931245006e-06 2.2591788488445 0.577777777777778 19.1 19 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000231379319756442 0.00164626386006708 2.23435270764841 0.571428571428571 19.1 19 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00270186554006157 0.0135378685334775 2.23435270764841 0.571428571428571 19.1 19 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00168573196304723 0.00877228711568585 2.1994409465914 0.5625 19.1 19 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 5.92972252225613e-05 0.000511393645404271 2.17228735465818 0.555555555555556 19.1 19 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00105415367456276 0.00585961202696412 2.17228735465818 0.555555555555556 19.1 19 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00105415367456276 0.00585961202696412 2.17228735465818 0.555555555555556 19.1 19 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0211197092889113 0.0701316269083848 2.17228735465818 0.555555555555556 19.1 19 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0211197092889113 0.0701316269083848 2.17228735465818 0.555555555555556 19.1 19 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0211197092889113 0.0701316269083848 2.17228735465818 0.555555555555556 19.1 19 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0211197092889113 0.0701316269083848 2.17228735465818 0.555555555555556 19.1 19 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0211197092889113 0.0701316269083848 2.17228735465818 0.555555555555556 19.1 19 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0211197092889113 0.0701316269083848 2.17228735465818 0.555555555555556 19.1 19 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0211197092889113 0.0701316269083848 2.17228735465818 0.555555555555556 19.1 19 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00066060035651607 0.00394972398034608 2.15056448111159 0.55 19.1 19 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00066060035651607 0.00394972398034608 2.15056448111159 0.55 19.1 19 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00066060035651607 0.00394972398034608 2.15056448111159 0.55 19.1 19 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00066060035651607 0.00394972398034608 2.15056448111159 0.55 19.1 19 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 5.66591987477951e-08 1.67970916287734e-06 2.14673103283867 0.549019607843137 19.1 19 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 5.66591987477951e-08 1.67970916287734e-06 2.14673103283867 0.549019607843137 19.1 19 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0127418294017719 0.0463724379506942 2.13279122093712 0.545454545454545 19.1 19 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0127418294017719 0.0463724379506942 2.13279122093712 0.545454545454545 19.1 19 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0127418294017719 0.0463724379506942 2.13279122093712 0.545454545454545 19.1 19 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0127418294017719 0.0463724379506942 2.13279122093712 0.545454545454545 19.1 19 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0127418294017719 0.0463724379506942 2.13279122093712 0.545454545454545 19.1 19 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 3.76907128277139e-07 8.81740006016284e-06 2.12506371651343 0.543478260869565 19.1 19 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00026087927332366 0.00181088393141253 2.11798017079172 0.541666666666667 19.1 19 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00026087927332366 0.00181088393141253 2.11798017079172 0.541666666666667 19.1 19 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00026087927332366 0.00181088393141253 2.11798017079172 0.541666666666667 19.1 19 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00776088936470356 0.0322916537016759 2.10544774374562 0.538461538461538 19.1 19 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.00776088936470356 0.0322916537016759 2.10544774374562 0.538461538461538 19.1 19 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00776088936470356 0.0322916537016759 2.10544774374562 0.538461538461538 19.1 19 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00776088936470356 0.0322916537016759 2.10544774374562 0.538461538461538 19.1 19 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00776088936470356 0.0322916537016759 2.10544774374562 0.538461538461538 19.1 19 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00476128060568698 0.0216463332328836 2.08539586047185 0.533333333333333 19.1 19 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00476128060568698 0.0216463332328836 2.08539586047185 0.533333333333333 19.1 19 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00476128060568698 0.0216463332328836 2.08539586047185 0.533333333333333 19.1 19 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 6.49306236756383e-07 1.3199468212919e-05 2.07984959488549 0.531914893617021 19.1 19 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 6.82302104436802e-09 2.85563498415755e-07 2.07724978289188 0.53125 19.1 19 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 4.14309767571518e-07 9.07019691160416e-06 2.07475608567352 0.530612244897959 19.1 19 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00293761123536391 0.0144202168838354 2.07006206738014 0.529411764705882 19.1 19 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 6.68752908605906e-06 8.27509033866265e-05 2.05281155015198 0.525 19.1 19 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00113274349695166 0.00619959229293159 2.04815664867771 0.523809523809524 19.1 19 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.000706942469922313 0.00417418728091059 2.0400611678529 0.521739130434783 19.1 19 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000706942469922313 0.00417418728091059 2.0400611678529 0.521739130434783 19.1 19 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.92797258661173e-09 9.14501663582832e-08 2.03540349395369 0.520547945205479 19.1 19 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000442383572258227 0.00282292297454465 2.03326096396005 0.52 19.1 19 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000442383572258227 0.00282292297454465 2.03326096396005 0.52 19.1 19 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 4.43270170368474e-07 9.41452914081102e-06 2.03025318146899 0.519230769230769 19.1 19 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000277468517065149 0.00190742850137057 2.02746819768096 0.518518518518518 19.1 19 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 4.3709366630091e-05 0.000389358048039101 2.01091743688357 0.514285714285714 19.1 19 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 4.3709366630091e-05 0.000389358048039101 2.01091743688357 0.514285714285714 19.1 19 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 1.79963237748804e-06 3.16157638662405e-05 1.99495777468608 0.510204081632653 19.1 19 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.60216434916361e-12 4.69743993442991e-10 1.95505861919236 0.5 19.1 19 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 4.57046238091589e-06 6.40178866500636e-05 1.95505861919236 0.5 19.1 19 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.13510021434395e-05 0.000123963576258351 1.95505861919236 0.5 19.1 19 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.13510021434395e-05 0.000123963576258351 1.95505861919236 0.5 19.1 19 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.79111154508802e-05 0.000179816783163364 1.95505861919236 0.5 19.1 19 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 7.08059425941232e-05 0.000599743192329984 1.95505861919236 0.5 19.1 19 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000283272956046611 0.00193796834833811 1.95505861919236 0.5 19.1 19 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000451261514154379 0.00285397837618525 1.95505861919236 0.5 19.1 19 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00115300566652097 0.00626231703610434 1.95505861919236 0.5 19.1 19 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00115300566652097 0.00626231703610434 1.95505861919236 0.5 19.1 19 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00298087011058597 0.0145765572761644 1.95505861919236 0.5 19.1 19 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00783682924832674 0.03241804657084 1.95505861919236 0.5 19.1 19 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00783682924832674 0.03241804657084 1.95505861919236 0.5 19.1 19 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0128199131893456 0.0464191767644752 1.95505861919236 0.5 19.1 19 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0128199131893456 0.0464191767644752 1.95505861919236 0.5 19.1 19 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0211429852028792 0.0701316269083848 1.95505861919236 0.5 19.1 19 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0211429852028792 0.0701316269083848 1.95505861919236 0.5 19.1 19 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0211429852028792 0.0701316269083848 1.95505861919236 0.5 19.1 19 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0211429852028792 0.0701316269083848 1.95505861919236 0.5 19.1 19 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0352511834007409 0.099654233236592 1.95505861919236 0.5 19.1 19 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0352511834007409 0.099654233236592 1.95505861919236 0.5 19.1 19 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0352511834007409 0.099654233236592 1.95505861919236 0.5 19.1 19 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0352511834007409 0.099654233236592 1.95505861919236 0.5 19.1 19 1 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.0352511834007409 0.099654233236592 1.95505861919236 0.5 19.1 19 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0352511834007409 0.099654233236592 1.95505861919236 0.5 19.1 19 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0352511834007409 0.099654233236592 1.95505861919236 0.5 19.1 19 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.37367659798001e-10 1.40739241621898e-08 1.93447905477981 0.494736842105263 19.1 19 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.37367659798001e-10 1.40739241621898e-08 1.93447905477981 0.494736842105263 19.1 19 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.1433437461139e-22 1.17919563014402e-19 1.92875738216286 0.493273542600897 19.1 19 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.92170267816397e-06 4.83439873375271e-05 1.91817072071703 0.490566037735849 19.1 19 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 5.15096219029678e-14 9.1622739959904e-12 1.91286310942562 0.489208633093525 19.1 19 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.79437689453252e-05 0.000179816783163364 1.91161287209919 0.488888888888889 19.1 19 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.80073347168833e-12 2.65696248680833e-10 1.90658609144379 0.487603305785124 19.1 19 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.80073347168833e-12 2.65696248680833e-10 1.90658609144379 0.487603305785124 19.1 19 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.32645757420554e-08 5.10148412998511e-07 1.90618215371255 0.4875 19.1 19 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00113174073608103 0.00619959229293159 1.88264904070375 0.481481481481481 19.1 19 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00113174073608103 0.00619959229293159 1.88264904070375 0.481481481481481 19.1 19 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 7.85168034049559e-08 2.10810209896702e-06 1.87685627442466 0.48 19.1 19 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 7.85168034049559e-08 2.10810209896702e-06 1.87685627442466 0.48 19.1 19 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 7.85168034049559e-08 2.10810209896702e-06 1.87685627442466 0.48 19.1 19 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 7.85168034049559e-08 2.10810209896702e-06 1.87685627442466 0.48 19.1 19 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 7.85168034049559e-08 2.10810209896702e-06 1.87685627442466 0.48 19.1 19 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 1.76564414265558e-05 0.000179465115357063 1.87359784339268 0.479166666666667 19.1 19 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.77923455811004e-05 0.000265426226589973 1.87005607053182 0.478260869565217 19.1 19 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.70180000803967e-07 9.83920795800066e-06 1.86751868101957 0.477611940298507 19.1 19 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 8.28772894596414e-09 3.27595508058527e-07 1.86619231831998 0.477272727272727 19.1 19 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.37788388519017e-05 0.000389358048039101 1.86619231831998 0.477272727272727 19.1 19 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00466098521388988 0.0214646665351628 1.86196058970701 0.476190476190476 19.1 19 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00466098521388988 0.0214646665351628 1.86196058970701 0.476190476190476 19.1 19 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000108896428343548 0.000857078338332898 1.85730568823274 0.475 19.1 19 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.32908578523154e-09 1.52815776528532e-07 1.8521607971296 0.473684210526316 19.1 19 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00752136900251771 0.0317593711886727 1.8521607971296 0.473684210526316 19.1 19 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 2.92774359943846e-07 7.43960561071593e-06 1.84644425145945 0.472222222222222 19.1 19 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000271915890106382 0.00187833160981253 1.84644425145945 0.472222222222222 19.1 19 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.96554174661156e-08 7.17170744981601e-07 1.84269892843418 0.471264367816092 19.1 19 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0121916897042937 0.0452970612250912 1.84005517100457 0.470588235294118 19.1 19 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0121916897042937 0.0452970612250912 1.84005517100457 0.470588235294118 19.1 19 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0121916897042937 0.0452970612250912 1.84005517100457 0.470588235294118 19.1 19 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 3.42793358333883e-10 1.95117979563646e-08 1.83176663419825 0.468468468468468 19.1 19 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.27507286056202e-06 6.20758028630587e-05 1.82472137791287 0.466666666666667 19.1 19 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.27507286056202e-06 6.20758028630587e-05 1.82472137791287 0.466666666666667 19.1 19 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.27507286056202e-06 6.20758028630587e-05 1.82472137791287 0.466666666666667 19.1 19 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.27507286056202e-06 6.20758028630587e-05 1.82472137791287 0.466666666666667 19.1 19 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.27507286056202e-06 6.20758028630587e-05 1.82472137791287 0.466666666666667 19.1 19 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.27507286056202e-06 6.20758028630587e-05 1.82472137791287 0.466666666666667 19.1 19 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.27507286056202e-06 6.20758028630587e-05 1.82472137791287 0.466666666666667 19.1 19 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.0174532563048e-18 2.41305997286955e-16 1.82355243404489 0.466367713004484 19.1 19 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000164355804272596 0.00124403356106332 1.81200554949536 0.463414634146341 19.1 19 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000164355804272596 0.00124403356106332 1.81200554949536 0.463414634146341 19.1 19 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000164355804272596 0.00124403356106332 1.81200554949536 0.463414634146341 19.1 19 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.2164968110897e-29 5.77024987393546e-27 1.80869059422609 0.462566844919786 19.1 19 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 2.56701798877632e-05 0.00025105633427871 1.8046694946391 0.461538461538462 19.1 19 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.0027419988430058 0.0136428823552352 1.8046694946391 0.461538461538462 19.1 19 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.0027419988430058 0.0136428823552352 1.8046694946391 0.461538461538462 19.1 19 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0326133530641726 0.0951000028899951 1.8046694946391 0.461538461538462 19.1 19 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0326133530641726 0.0951000028899951 1.8046694946391 0.461538461538462 19.1 19 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0326133530641726 0.0951000028899951 1.8046694946391 0.461538461538462 19.1 19 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0326133530641726 0.0951000028899951 1.8046694946391 0.461538461538462 19.1 19 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0326133530641726 0.0951000028899951 1.8046694946391 0.461538461538462 19.1 19 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 4.02149862250329e-05 0.000366832855116807 1.79865392965697 0.46 19.1 19 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.06501878707314e-07 2.80652172963904e-06 1.79405379172946 0.458823529411765 19.1 19 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 6.30227570723202e-05 0.000537014271340788 1.79213706759299 0.458333333333333 19.1 19 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00437669444973664 0.020486961190708 1.79213706759299 0.458333333333333 19.1 19 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00437669444973664 0.020486961190708 1.79213706759299 0.458333333333333 19.1 19 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.00079759516454e-07 8.89552340299865e-06 1.78182557698544 0.455696202531646 19.1 19 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.00079759516454e-07 8.89552340299865e-06 1.78182557698544 0.455696202531646 19.1 19 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.00079759516454e-07 8.89552340299865e-06 1.78182557698544 0.455696202531646 19.1 19 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00101676172289877 0.00569626744757854 1.7773260174476 0.454545454545455 19.1 19 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0540089783998817 0.139735956841876 1.7773260174476 0.454545454545455 19.1 19 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 2.33416487023485e-06 3.95418644088595e-05 1.76230636096213 0.450704225352113 19.1 19 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000381597849614753 0.00253744738318595 1.75955275727312 0.45 19.1 19 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0112363226413709 0.042622726863534 1.75955275727312 0.45 19.1 19 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0112363226413709 0.042622726863534 1.75955275727312 0.45 19.1 19 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000599227864728817 0.00369134740913033 1.74926297506685 0.447368421052632 19.1 19 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.53565563525208e-07 8.52752198129442e-06 1.74805241245434 0.447058823529412 19.1 19 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.03347166303951e-13 1.63403352945025e-11 1.74255224754101 0.445652173913043 19.1 19 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00403020532854562 0.0191166072750681 1.73782988372654 0.444444444444444 19.1 19 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 8.47421114010013e-07 1.6295678989679e-05 1.73782988372654 0.444444444444444 19.1 19 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 8.47421114010013e-07 1.6295678989679e-05 1.73782988372654 0.444444444444444 19.1 19 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0180881864307966 0.0628245506439612 1.73782988372654 0.444444444444444 19.1 19 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.35951663355797e-05 0.000144372549966641 1.73782988372654 0.444444444444444 19.1 19 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.36004145455293e-09 6.91192496367433e-08 1.73432619444483 0.443548387096774 19.1 19 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.61210556010795e-09 2.05094569126051e-07 1.7126959804495 0.43801652892562 19.1 19 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0292312958291624 0.0872036351465369 1.71067629179331 0.4375 19.1 19 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0292312958291624 0.0872036351465369 1.71067629179331 0.4375 19.1 19 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0292312958291624 0.0872036351465369 1.71067629179331 0.4375 19.1 19 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0292312958291624 0.0872036351465369 1.71067629179331 0.4375 19.1 19 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0292312958291624 0.0872036351465369 1.71067629179331 0.4375 19.1 19 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0292312958291624 0.0872036351465369 1.71067629179331 0.4375 19.1 19 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0292312958291624 0.0872036351465369 1.71067629179331 0.4375 19.1 19 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.000862222234258995 0.00500792750755327 1.70441007827026 0.435897435897436 19.1 19 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0101595765689344 0.0400473059767135 1.70005097321075 0.434782608695652 19.1 19 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0101595765689344 0.0400473059767135 1.70005097321075 0.434782608695652 19.1 19 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0101595765689344 0.0400473059767135 1.70005097321075 0.434782608695652 19.1 19 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.15861951105838e-05 0.000123963576258351 1.70005097321075 0.434782608695652 19.1 19 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 4.46622937319396e-06 6.40178866500636e-05 1.69781406403547 0.434210526315789 19.1 19 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00366065391653281 0.0175390926707953 1.69438413663338 0.433333333333333 19.1 19 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.00366065391653281 0.0175390926707953 1.69438413663338 0.433333333333333 19.1 19 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00134773778909827 0.00715806005247325 1.69086150849069 0.432432432432432 19.1 19 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00134773778909827 0.00715806005247325 1.69086150849069 0.432432432432432 19.1 19 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.58302256813206e-06 2.8158013930649e-05 1.68225974209575 0.430232558139535 19.1 19 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 6.13913118795005e-07 1.26608459136999e-05 1.68177085521923 0.43010752688172 19.1 19 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00576174227864172 0.025541929166689 1.67576453073631 0.428571428571429 19.1 19 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0474584329702928 0.127181450313986 1.67576453073631 0.428571428571429 19.1 19 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.48619825356309e-05 0.000154369351446735 1.66046074506748 0.424657534246575 19.1 19 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00329209559283995 0.0159885734764889 1.65883761628442 0.424242424242424 19.1 19 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.31672184807684e-13 4.71969518981334e-11 1.65714492483924 0.423809523809524 19.1 19 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.39522958378304e-06 5.30924362387171e-05 1.65604965390411 0.423529411764706 19.1 19 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.39522958378304e-06 5.30924362387171e-05 1.65604965390411 0.423529411764706 19.1 19 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.39522958378304e-06 5.30924362387171e-05 1.65604965390411 0.423529411764706 19.1 19 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.025773144560454 0.081873153008347 1.64636515300409 0.421052631578947 19.1 19 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.80307984789527e-08 1.20261836078999e-06 1.63972658383875 0.419354838709677 19.1 19 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.80307984789527e-08 1.20261836078999e-06 1.63972658383875 0.419354838709677 19.1 19 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.80307984789527e-08 1.20261836078999e-06 1.63972658383875 0.419354838709677 19.1 19 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00514364642982396 0.0230896178852981 1.63972658383875 0.419354838709677 19.1 19 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00514364642982396 0.0230896178852981 1.63972658383875 0.419354838709677 19.1 19 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.83661816800709e-10 2.64711832810542e-08 1.6373615935736 0.41875 19.1 19 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.00109263905882552 0.0060499042050923 1.63679326257965 0.418604651162791 19.1 19 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000633422985410754 0.00388517632861855 1.62921551599363 0.416666666666667 19.1 19 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0142902066540756 0.051480921693037 1.62921551599363 0.416666666666667 19.1 19 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0774846878263121 0.180164560092879 1.62921551599363 0.416666666666667 19.1 19 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0774846878263121 0.180164560092879 1.62921551599363 0.416666666666667 19.1 19 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0774846878263121 0.180164560092879 1.62921551599363 0.416666666666667 19.1 19 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0774846878263121 0.180164560092879 1.62921551599363 0.416666666666667 19.1 19 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0774846878263121 0.180164560092879 1.62921551599363 0.416666666666667 19.1 19 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0774846878263121 0.180164560092879 1.62921551599363 0.416666666666667 19.1 19 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0774846878263121 0.180164560092879 1.62921551599363 0.416666666666667 19.1 19 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0774846878263121 0.180164560092879 1.62921551599363 0.416666666666667 19.1 19 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00293876521174439 0.0144202168838354 1.62921551599363 0.416666666666667 19.1 19 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.10699131903432e-08 1.05267824928234e-06 1.62420254517519 0.415384615384615 19.1 19 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00168911220639348 0.00877228711568585 1.62126812323269 0.414634146341463 19.1 19 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00803338538634498 0.0329803303838587 1.61797954691781 0.413793103448276 19.1 19 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.000975499391790362 0.00550847474014954 1.61504842455021 0.41304347826087 19.1 19 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 7.35566645183891e-05 0.000605035454391142 1.610048274629 0.411764705882353 19.1 19 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00456079345383704 0.0212091800157193 1.610048274629 0.411764705882353 19.1 19 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00456079345383704 0.0212091800157193 1.610048274629 0.411764705882353 19.1 19 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0411590201165705 0.112841649479628 1.610048274629 0.411764705882353 19.1 19 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0411590201165705 0.112841649479628 1.610048274629 0.411764705882353 19.1 19 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0225127893429055 0.0738149751957479 1.59959341570284 0.409090909090909 19.1 19 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0225127893429055 0.0738149751957479 1.59959341570284 0.409090909090909 19.1 19 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0125390351339106 0.0463724379506942 1.59301072674933 0.407407407407407 19.1 19 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 5.31037925258013e-10 2.79876654682279e-08 1.59055616476666 0.406779661016949 19.1 19 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.00707096074145947 0.0303071600454724 1.58848512809379 0.40625 19.1 19 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00402355663627582 0.0191166072750681 1.58518266421002 0.405405405405405 19.1 19 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.7574704496586e-14 5.60554349980599e-12 1.58129741258205 0.404411764705882 19.1 19 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.43825312054109e-06 4.08192257709409e-05 1.57908580780921 0.403846153846154 19.1 19 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000259789711470566 0.00181088393141253 1.57666017676803 0.403225806451613 19.1 19 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.000259789711470566 0.00181088393141253 1.57666017676803 0.403225806451613 19.1 19 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.9474704248372e-08 7.17170744981601e-07 1.56919178645702 0.401315789473684 19.1 19 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000229959891102409 0.00164438655798356 1.56404689535389 0.4 19.1 19 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.26764535015494e-06 5.28393106053463e-05 1.56404689535389 0.4 19.1 19 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00117145119342326 0.00633456900511105 1.56404689535389 0.4 19.1 19 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0061969678524642 0.0273011927370172 1.56404689535389 0.4 19.1 19 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0109485396995531 0.042622726863534 1.56404689535389 0.4 19.1 19 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0109485396995531 0.042622726863534 1.56404689535389 0.4 19.1 19 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0195542133999824 0.0668885713177281 1.56404689535389 0.4 19.1 19 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0195542133999824 0.0668885713177281 1.56404689535389 0.4 19.1 19 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0195542133999824 0.0668885713177281 1.56404689535389 0.4 19.1 19 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0195542133999824 0.0668885713177281 1.56404689535389 0.4 19.1 19 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.035464359173176 0.099654233236592 1.56404689535389 0.4 19.1 19 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0658499104837901 0.157751553229686 1.56404689535389 0.4 19.1 19 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0658499104837901 0.157751553229686 1.56404689535389 0.4 19.1 19 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0658499104837901 0.157751553229686 1.56404689535389 0.4 19.1 19 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0658499104837901 0.157751553229686 1.56404689535389 0.4 19.1 19 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.000598057673783248 0.00369134740913033 1.5505637324629 0.396551724137931 19.1 19 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.000598057673783248 0.00369134740913033 1.5505637324629 0.396551724137931 19.1 19 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 8.27889934825565e-13 1.07098852477889e-10 1.54900798289856 0.396153846153846 19.1 19 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00309815592539675 0.0150982050747931 1.54586030354745 0.395348837209302 19.1 19 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00541363141437841 0.0241492084722899 1.54346733094134 0.394736842105263 19.1 19 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.27538666124663e-06 3.90105448066741e-05 1.54346733094133 0.394736842105263 19.1 19 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00952722308806212 0.0379754578552168 1.54034921512125 0.393939393939394 19.1 19 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00952722308806212 0.0379754578552168 1.54034921512125 0.393939393939394 19.1 19 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 4.08079399007749e-12 3.05629991993698e-10 1.53611748650828 0.392857142857143 19.1 19 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 4.08079399007749e-12 3.05629991993698e-10 1.53611748650828 0.392857142857143 19.1 19 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 4.08079399007749e-12 3.05629991993698e-10 1.53611748650828 0.392857142857143 19.1 19 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0169243422755552 0.0593185691086579 1.53611748650828 0.392857142857143 19.1 19 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0169243422755552 0.0593185691086579 1.53611748650828 0.392857142857143 19.1 19 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 5.08364103405284e-06 6.40178866500636e-05 1.52850037500493 0.390909090909091 19.1 19 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00471791204175703 0.0216463332328836 1.52589941010135 0.390243902439024 19.1 19 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.45866526592289e-05 0.000152623578927079 1.52494572297004 0.39 19.1 19 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.000793107609994219 0.00464441205358754 1.52428299123472 0.389830508474576 19.1 19 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.000793107609994219 0.00464441205358754 1.52428299123472 0.389830508474576 19.1 19 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.20169547195988e-05 0.000380828831630503 1.52060114826072 0.388888888888889 19.1 19 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00827036953292225 0.0338182064521505 1.52060114826072 0.388888888888889 19.1 19 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0558404597347902 0.144212294378596 1.52060114826072 0.388888888888889 19.1 19 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.000404726420285828 0.00266632266697562 1.5173589283284 0.388059701492537 19.1 19 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 7.67052645108197e-09 3.11861689711133e-07 1.51704002144981 0.387978142076503 19.1 19 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0146147880804346 0.0523849960666459 1.51359376969731 0.387096774193548 19.1 19 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0146147880804346 0.0523849960666459 1.51359376969731 0.387096774193548 19.1 19 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.67884980972208e-05 0.000173116179654675 1.50389124553258 0.384615384615385 19.1 19 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00716680644684111 0.0304767813254194 1.50389124553258 0.384615384615385 19.1 19 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0261052999981987 0.081873153008347 1.50389124553258 0.384615384615385 19.1 19 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0261052999981987 0.081873153008347 1.50389124553258 0.384615384615385 19.1 19 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.105529272052649 0.226689608137267 1.50389124553258 0.384615384615385 19.1 19 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.105529272052649 0.226689608137267 1.50389124553258 0.384615384615385 19.1 19 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.105529272052649 0.226689608137267 1.50389124553258 0.384615384615385 19.1 19 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 9.34306723686475e-05 0.000751140377291443 1.50039382403134 0.383720930232558 19.1 19 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000158915631842061 0.00122236186006082 1.49646462209785 0.382716049382716 19.1 19 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0126016795282968 0.0463724379506942 1.49504482644121 0.382352941176471 19.1 19 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0126016795282968 0.0463724379506942 1.49504482644121 0.382352941176471 19.1 19 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 8.17754437022215e-05 0.000661173047660575 1.49375265286607 0.382022471910112 19.1 19 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.07623489225633e-06 2.03801045518474e-05 1.4909080117582 0.381294964028777 19.1 19 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 7.15179006502059e-05 0.000600013723002203 1.4875446015594 0.380434782608696 19.1 19 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0223577048189615 0.0736458656420884 1.483147918008 0.379310344827586 19.1 19 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0223577048189615 0.0736458656420884 1.483147918008 0.379310344827586 19.1 19 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0223577048189615 0.0736458656420884 1.483147918008 0.379310344827586 19.1 19 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.39090277277577e-06 2.53750595597426e-05 1.48025866881707 0.378571428571429 19.1 19 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.7797709323256e-07 8.81740006016284e-06 1.47882639144037 0.378205128205128 19.1 19 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0053631373048349 0.0239991961785536 1.47715540116756 0.377777777777778 19.1 19 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00268159087593606 0.0134837590687527 1.4755159390131 0.377358490566038 19.1 19 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.000686770243517629 0.00408901278880998 1.47337751011598 0.376811594202899 19.1 19 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000179656972659279 0.00131103524150848 1.47204413680366 0.376470588235294 19.1 19 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000179656972659279 0.00131103524150848 1.47204413680366 0.376470588235294 19.1 19 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000179656972659279 0.00131103524150848 1.47204413680366 0.376470588235294 19.1 19 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000179656972659279 0.00131103524150848 1.47204413680366 0.376470588235294 19.1 19 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000179656972659279 0.00131103524150848 1.47204413680366 0.376470588235294 19.1 19 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000179656972659279 0.00131103524150848 1.47204413680366 0.376470588235294 19.1 19 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000179656972659279 0.00131103524150848 1.47204413680366 0.376470588235294 19.1 19 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.46332201899838e-05 0.000245126379932496 1.47077804379609 0.376146788990826 19.1 19 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0401525006665739 0.111620386469602 1.46629396439427 0.375 19.1 19 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 4.25097462660453e-07 9.16535892978522e-06 1.46629396439427 0.375 19.1 19 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000156514755394935 0.00121043748329887 1.46629396439427 0.375 19.1 19 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.000597023726186996 0.00369134740913033 1.46629396439427 0.375 19.1 19 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00934532549036698 0.0374602765430767 1.46629396439427 0.375 19.1 19 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00934532549036698 0.0374602765430767 1.46629396439427 0.375 19.1 19 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0878210792765669 0.199951033296888 1.46629396439427 0.375 19.1 19 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.0878210792765669 0.199951033296888 1.46629396439427 0.375 19.1 19 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0878210792765669 0.199951033296888 1.46629396439427 0.375 19.1 19 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0878210792765669 0.199951033296888 1.46629396439427 0.375 19.1 19 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0878210792765669 0.199951033296888 1.46629396439427 0.375 19.1 19 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0878210792765669 0.199951033296888 1.46629396439427 0.375 19.1 19 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00400218456425594 0.0191111028017993 1.45671034371195 0.372549019607843 19.1 19 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.40385499219739e-06 9.08248763266973e-05 1.45492734451524 0.372093023255814 19.1 19 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00804228717020306 0.0329803303838587 1.45492734451524 0.372093023255814 19.1 19 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00804228717020306 0.0329803303838587 1.45492734451524 0.372093023255814 19.1 19 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000450482680436716 0.00285397837618525 1.45376153734816 0.371794871794872 19.1 19 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000883219008787471 0.00510902703050639 1.45232925997147 0.371428571428571 19.1 19 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 7.9469913595896e-07 1.59275615559099e-05 1.45092400669622 0.371069182389937 19.1 19 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.11046029117355e-31 1.50159249716998e-28 1.45081273098437 0.3710407239819 19.1 19 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0340854558007212 0.0985845601715982 1.44819156977212 0.37037037037037 19.1 19 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0340854558007212 0.0985845601715982 1.44819156977212 0.37037037037037 19.1 19 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0340854558007212 0.0985845601715982 1.44819156977212 0.37037037037037 19.1 19 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0340854558007212 0.0985845601715982 1.44819156977212 0.37037037037037 19.1 19 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000391063288094896 0.0025882932974839 1.44819156977212 0.37037037037037 19.1 19 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.15934427399817e-06 2.14252844402519e-05 1.44450190972174 0.369426751592357 19.1 19 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.014029742966232 0.0506708737079903 1.44056950887858 0.368421052631579 19.1 19 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0733797269198197 0.173454072104491 1.44056950887858 0.368421052631579 19.1 19 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0733797269198197 0.173454072104491 1.44056950887858 0.368421052631579 19.1 19 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0733797269198197 0.173454072104491 1.44056950887858 0.368421052631579 19.1 19 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000497771459820017 0.00313419817399949 1.43053069697002 0.365853658536585 19.1 19 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.0120149870953342 0.0449929648333174 1.43053069697002 0.365853658536585 19.1 19 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.0120149870953342 0.0449929648333174 1.43053069697002 0.365853658536585 19.1 19 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000431048895421906 0.00278810262811533 1.42604275752854 0.364705882352941 19.1 19 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000431048895421906 0.00278810262811533 1.42604275752854 0.364705882352941 19.1 19 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.86677951762147e-06 9.56788654151739e-05 1.42439985112586 0.364285714285714 19.1 19 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0102927219108682 0.0404600643070868 1.42186081395808 0.363636363636364 19.1 19 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0246347195671097 0.0798524053394011 1.42186081395808 0.363636363636364 19.1 19 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0246347195671097 0.0798524053394011 1.42186081395808 0.363636363636364 19.1 19 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0615256402254746 0.150173217908834 1.42186081395808 0.363636363636364 19.1 19 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0615256402254746 0.150173217908834 1.42186081395808 0.363636363636364 19.1 19 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0615256402254746 0.150173217908834 1.42186081395808 0.363636363636364 19.1 19 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0615256402254746 0.150173217908834 1.42186081395808 0.363636363636364 19.1 19 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.28338322117381e-25 8.12313580932585e-23 1.41685426179625 0.36235595390525 19.1 19 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.52562142849456e-05 0.000249580506440816 1.41626293673777 0.362204724409449 19.1 19 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00882037294486598 0.0355563475936099 1.41429772452213 0.361702127659574 19.1 19 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.00241662248670922 0.0121945170162667 1.40063901076467 0.358208955223881 19.1 19 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.00241662248670922 0.0121945170162667 1.40063901076467 0.358208955223881 19.1 19 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 5.28289887795332e-05 0.000461200313087581 1.39874112592624 0.357723577235772 19.1 19 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 5.28289887795332e-05 0.000461200313087581 1.39874112592624 0.357723577235772 19.1 19 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0152440852438813 0.0545033500051335 1.39647044228026 0.357142857142857 19.1 19 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.043619407759147 0.118004595515715 1.39647044228026 0.357142857142857 19.1 19 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.137790849320626 0.278517583214844 1.39647044228026 0.357142857142857 19.1 19 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.137790849320626 0.278517583214844 1.39647044228026 0.357142857142857 19.1 19 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.4322057357559e-05 0.000321317681709253 1.39223871366729 0.356060606060606 19.1 19 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000378560889644268 0.00252907110781124 1.38236468023702 0.353535353535354 19.1 19 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0311981959519167 0.0919151818624792 1.38004137825343 0.352941176470588 19.1 19 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.113273111545656 0.236606727572983 1.38004137825343 0.352941176470588 19.1 19 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.113273111545656 0.236606727572983 1.38004137825343 0.352941176470588 19.1 19 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.113273111545656 0.236606727572983 1.38004137825343 0.352941176470588 19.1 19 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 9.46195509267507e-05 0.000756424836903181 1.37815607582412 0.352459016393443 19.1 19 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0937956941680122 0.210522512304545 1.36854103343465 0.35 19.1 19 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.92988084548546e-06 3.34904932088513e-05 1.36446799464467 0.348958333333333 19.1 19 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.00122341786085007 0.00656952307920621 1.36399438548304 0.348837209302326 19.1 19 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 8.13800690000799e-07 1.60838664148769e-05 1.35923123048612 0.347619047619048 19.1 19 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.16621900096092e-06 5.17876969927286e-05 1.3591316604011 0.347593582887701 19.1 19 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.00276666082751083 0.0136699942970414 1.3555073093067 0.346666666666667 19.1 19 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0118224347470023 0.0445061498544558 1.35350212097932 0.346153846153846 19.1 19 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0118224347470023 0.0445061498544558 1.35350212097932 0.346153846153846 19.1 19 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.065309839330649 0.157518476894091 1.35350212097932 0.346153846153846 19.1 19 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.065309839330649 0.157518476894091 1.35350212097932 0.346153846153846 19.1 19 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.065309839330649 0.157518476894091 1.35350212097932 0.346153846153846 19.1 19 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.065309839330649 0.157518476894091 1.35350212097932 0.346153846153846 19.1 19 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.065309839330649 0.157518476894091 1.35350212097932 0.346153846153846 19.1 19 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.065309839330649 0.157518476894091 1.35350212097932 0.346153846153846 19.1 19 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0461330068153454 0.123862771128748 1.34410280069475 0.34375 19.1 19 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0461330068153454 0.123862771128748 1.34410280069475 0.34375 19.1 19 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0461330068153454 0.123862771128748 1.34410280069475 0.34375 19.1 19 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.38842193841905e-05 0.000146349956916319 1.34126114572499 0.343023255813953 19.1 19 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00462937075472664 0.0214579628142541 1.34061162458905 0.342857142857143 19.1 19 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0389261511187267 0.108611594199898 1.34061162458905 0.342857142857143 19.1 19 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.020102998460168 0.0686008796374559 1.33110374072671 0.340425531914894 19.1 19 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0105998884738481 0.0415527308492724 1.32546347063889 0.338983050847458 19.1 19 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.03071259352403e-07 7.56614740453454e-06 1.318353704896 0.337164750957854 19.1 19 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.000909156738717787 0.0052377734380381 1.31555346338177 0.336448598130841 19.1 19 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000430033084122421 0.00278810262811533 1.31405579322765 0.336065573770492 19.1 19 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 7.2712192958169e-05 0.000601566573136479 1.31162160528095 0.335443037974684 19.1 19 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.0818537932343e-12 1.18421380597877e-10 1.30832820143671 0.334600760456274 19.1 19 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0809220310956127 0.187239106096027 1.30337241279491 0.333333333333333 19.1 19 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0809220310956127 0.187239106096027 1.30337241279491 0.333333333333333 19.1 19 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0970694098557951 0.217527197204404 1.30337241279491 0.333333333333333 19.1 19 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0110271447813768 0.042622726863534 1.30337241279491 0.333333333333333 19.1 19 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0404358864300004 0.111946043560098 1.30337241279491 0.333333333333333 19.1 19 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0404358864300004 0.111946043560098 1.30337241279491 0.333333333333333 19.1 19 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0479024583339349 0.128130071821784 1.30337241279491 0.333333333333333 19.1 19 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0568821504394634 0.14637124787587 1.30337241279491 0.333333333333333 19.1 19 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0568821504394634 0.14637124787587 1.30337241279491 0.333333333333333 19.1 19 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0677331611211361 0.161990400462818 1.30337241279491 0.333333333333333 19.1 19 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.117023966754294 0.243814208918536 1.30337241279491 0.333333333333333 19.1 19 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.141989437451089 0.282604967583247 1.30337241279491 0.333333333333333 19.1 19 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.141989437451089 0.282604967583247 1.30337241279491 0.333333333333333 19.1 19 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.141989437451089 0.282604967583247 1.30337241279491 0.333333333333333 19.1 19 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.141989437451089 0.282604967583247 1.30337241279491 0.333333333333333 19.1 19 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.141989437451089 0.282604967583247 1.30337241279491 0.333333333333333 19.1 19 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.173761318739043 0.328369663433809 1.30337241279491 0.333333333333333 19.1 19 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.173761318739043 0.328369663433809 1.30337241279491 0.333333333333333 19.1 19 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.173761318739043 0.328369663433809 1.30337241279491 0.333333333333333 19.1 19 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.173761318739043 0.328369663433809 1.30337241279491 0.333333333333333 19.1 19 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.00208548352711658 0.0106749750326866 1.29033868866696 0.33 19.1 19 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.000109016991734543 0.000857078338332898 1.28747762727302 0.329268292682927 19.1 19 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 9.63359627914038e-13 1.14238395876806e-10 1.28739411701633 0.329246935201401 19.1 19 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.000306832086442962 0.00206929885785941 1.28514342800057 0.328671328671329 19.1 19 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00972691970244484 0.0386631473088799 1.28475280689784 0.328571428571429 19.1 19 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0156248938753321 0.0557248721418486 1.28200565192941 0.327868852459016 19.1 19 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.06451186987342e-31 1.50159249716998e-28 1.27728813597332 0.326662362814719 19.1 19 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0298024991389687 0.0881683082635185 1.27677297579909 0.326530612244898 19.1 19 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0298024991389687 0.0881683082635185 1.27677297579909 0.326530612244898 19.1 19 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0298024991389687 0.0881683082635185 1.27677297579909 0.326530612244898 19.1 19 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.0351367492717851 0.099654233236592 1.27503822990806 0.326086956521739 19.1 19 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00626469661404579 0.0275143928450221 1.27196584863117 0.325301204819277 19.1 19 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0691657808465509 0.165139104269533 1.26503793006564 0.323529411764706 19.1 19 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0159989829475094 0.0569163818357647 1.26326864624737 0.323076923076923 19.1 19 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 0.000104979200820816 0.000834555322726376 1.26063889106392 0.322404371584699 19.1 19 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0985916947813072 0.219899657795925 1.25682339805223 0.321428571428571 19.1 19 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0985916947813072 0.219899657795925 1.25682339805223 0.321428571428571 19.1 19 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.50669912631031e-06 2.71396564144249e-05 1.25444034268998 0.320819112627986 19.1 19 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.118401349903684 0.245642784205651 1.25123751628311 0.32 19.1 19 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.000824430813503126 0.00480805347383175 1.24790975693129 0.319148936170213 19.1 19 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0190694988523818 0.0660240799682223 1.24412821221332 0.318181818181818 19.1 19 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0589339932063398 0.14932057025452 1.23979327070735 0.317073170731707 19.1 19 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.11284753820097e-08 7.51645511714995e-07 1.23912166005149 0.316901408450704 19.1 19 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.00568621209536468 0.0252858744115748 1.23687382030537 0.316326530612245 19.1 19 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.08846658182741e-06 2.03801045518474e-05 1.23540513973505 0.315950920245399 19.1 19 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.17365545769629 0.328369663433809 1.23477386475307 0.315789473684211 19.1 19 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0307791401221446 0.0908687062112277 1.23477386475307 0.315789473684211 19.1 19 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.0192915163474145 0.0666306499086671 1.22889398920662 0.314285714285714 19.1 19 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.26352203747322e-08 7.85607770566925e-07 1.22739106137637 0.31390134529148 19.1 19 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 7.63798930030307e-05 0.00062464705599605 1.22635495203884 0.313636363636364 19.1 19 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 2.8572448462885e-05 0.000271057294417902 1.22485600238557 0.313253012048193 19.1 19 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.00669383799785092 0.0292244356911448 1.22438014535279 0.313131313131313 19.1 19 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 5.72082201251207e-09 2.46688779509232e-07 1.22389848518546 0.313008130081301 19.1 19 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.4278364380831e-09 7.00624569445602e-08 1.22282692661095 0.312734082397004 19.1 19 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0501780719868536 0.133215291860621 1.22191163699522 0.3125 19.1 19 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0501780719868536 0.133215291860621 1.22191163699522 0.3125 19.1 19 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.212825063949259 0.372051678132428 1.22191163699522 0.3125 19.1 19 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.212825063949259 0.372051678132428 1.22191163699522 0.3125 19.1 19 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.212825063949259 0.372051678132428 1.22191163699522 0.3125 19.1 19 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.00499646764786537 0.0226432275888931 1.21966959729432 0.311926605504587 19.1 19 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.118293557455446 0.245642784205651 1.21348466018836 0.310344827586207 19.1 19 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.0011752116776875 0.00633456900511105 1.21087501575785 0.309677419354839 19.1 19 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.070020389315323 0.166342260426886 1.21027438330955 0.30952380952381 19.1 19 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.00584249093994006 0.0258194553029028 1.20858169186437 0.309090909090909 19.1 19 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0427331051555749 0.115827064069301 1.20858169186437 0.309090909090909 19.1 19 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0167174151241086 0.0588833705980361 1.20682630814343 0.308641975308642 19.1 19 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.141997576825033 0.282604967583247 1.20311299642607 0.307692307692308 19.1 19 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.141997576825033 0.282604967583247 1.20311299642607 0.307692307692308 19.1 19 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.141997576825033 0.282604967583247 1.20311299642607 0.307692307692308 19.1 19 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.141997576825033 0.282604967583247 1.20311299642607 0.307692307692308 19.1 19 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.01291096729685e-05 0.000283931940825392 1.19985547026246 0.306859205776173 19.1 19 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00158549771333429 0.00829471781645106 1.19544985632144 0.305732484076433 19.1 19 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.026581445319646 0.081873153008347 1.194758045062 0.305555555555556 19.1 19 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0984797983724661 0.219899657795925 1.194758045062 0.305555555555556 19.1 19 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0697619357744114 0.166005409041785 1.19003568124752 0.304347826086957 19.1 19 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0697619357744114 0.166005409041785 1.19003568124752 0.304347826086957 19.1 19 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0227395776108511 0.0740467252637095 1.18788371799029 0.30379746835443 19.1 19 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.00211853123134454 0.0108052686100476 1.18564845292956 0.303225806451613 19.1 19 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.000123424167259665 0.000959740929019141 1.18070206806127 0.301960784313725 19.1 19 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.058840974229053 0.14932057025452 1.18041275121048 0.30188679245283 19.1 19 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.0226555146928376 0.073942195889697 1.17774615613997 0.301204819277108 19.1 19 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00028644688556381 0.00195030582850383 1.1747133334203 0.300429184549356 19.1 19 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 0.00182432392582831 0.00937188789333462 1.17303517151541 0.3 19.1 19 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.20788107063698 0.367015835628316 1.17303517151541 0.3 19.1 19 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.20788107063698 0.367015835628316 1.17303517151541 0.3 19.1 19 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.20788107063698 0.367015835628316 1.17303517151541 0.3 19.1 19 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.20788107063698 0.367015835628316 1.17303517151541 0.3 19.1 19 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.20788107063698 0.367015835628316 1.17303517151541 0.3 19.1 19 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.139962298741579 0.28210531318593 1.17303517151541 0.3 19.1 19 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0165817527673326 0.0585504570419709 1.16900412281605 0.298969072164948 19.1 19 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.00671566442094473 0.0292244356911448 1.16408070455728 0.297709923664122 19.1 19 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.00671566442094473 0.0292244356911448 1.16408070455728 0.297709923664122 19.1 19 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.00134810969364921 0.00715806005247325 1.16081605514546 0.296875 19.1 19 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.049266765781191 0.131405184287377 1.16081605514546 0.296875 19.1 19 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.167713596079526 0.322090418719886 1.15855325581769 0.296296296296296 19.1 19 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.167713596079526 0.322090418719886 1.15855325581769 0.296296296296296 19.1 19 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.167713596079526 0.322090418719886 1.15855325581769 0.296296296296296 19.1 19 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 0.00275815944184087 0.0136699942970414 1.15683941964045 0.29585798816568 19.1 19 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.00365431429147226 0.0175390926707953 1.1514455671317 0.294478527607362 19.1 19 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.17819948453249e-12 2.82661116655609e-10 1.15072519327838 0.294294294294294 19.1 19 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.254305044117427 0.429271741137721 1.15003448187786 0.294117647058824 19.1 19 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.254305044117427 0.429271741137721 1.15003448187786 0.294117647058824 19.1 19 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.254305044117427 0.429271741137721 1.15003448187786 0.294117647058824 19.1 19 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.113398305133362 0.236606727572983 1.14442455757601 0.292682926829268 19.1 19 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.201843789401352 0.363625822692898 1.14045086119554 0.291666666666667 19.1 19 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0789056771263049 0.183169296167589 1.13748865116646 0.290909090909091 19.1 19 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0293085380532253 0.0872511498948527 1.13519532727298 0.290322580645161 19.1 19 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.16349526524723 0.316105655498381 1.13519532727298 0.290322580645161 19.1 19 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.16349526524723 0.316105655498381 1.13519532727298 0.290322580645161 19.1 19 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.110995920515424 0.232960464444615 1.12958942442225 0.288888888888889 19.1 19 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.110995920515424 0.232960464444615 1.12958942442225 0.288888888888889 19.1 19 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0924529112611544 0.207836481397508 1.12791843414944 0.288461538461538 19.1 19 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 5.54026602814957e-06 6.9156127702253e-05 1.12169019767804 0.286868686868687 19.1 19 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000993829772815337 0.00558980144947124 1.11936689569445 0.286274509803922 19.1 19 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.244223912190055 0.415209829207225 1.1171763538242 0.285714285714286 19.1 19 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.244223912190055 0.415209829207225 1.1171763538242 0.285714285714286 19.1 19 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.195362356598813 0.357787173024596 1.1171763538242 0.285714285714286 19.1 19 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0445970926862559 0.120420612699321 1.11082876090475 0.284090909090909 19.1 19 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.0883199156980484 0.20076555916665 1.10786655087567 0.283333333333333 19.1 19 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.127239611474005 0.258946043827201 1.10503313258698 0.282608695652174 19.1 19 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.15422753170432 0.300088583779345 1.10285358005723 0.282051282051282 19.1 19 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0355057598390388 0.099654233236592 1.09629455281814 0.280373831775701 19.1 19 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0417774153421015 0.113452790137043 1.09483282674772 0.28 19.1 19 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.234293626983778 0.401203166303148 1.09483282674772 0.28 19.1 19 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.234293626983778 0.401203166303148 1.09483282674772 0.28 19.1 19 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.234293626983778 0.401203166303148 1.09483282674772 0.28 19.1 19 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.234293626983778 0.401203166303148 1.09483282674772 0.28 19.1 19 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.234293626983778 0.401203166303148 1.09483282674772 0.28 19.1 19 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.100187775470034 0.222761257021653 1.08970480414 0.278688524590164 19.1 19 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.120081563466782 0.248727896380248 1.08614367732909 0.277777777777778 19.1 19 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.297503354373712 0.475671093566058 1.08614367732909 0.277777777777778 19.1 19 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.297503354373712 0.475671093566058 1.08614367732909 0.277777777777778 19.1 19 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.297503354373712 0.475671093566058 1.08614367732909 0.277777777777778 19.1 19 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.297503354373712 0.475671093566058 1.08614367732909 0.277777777777778 19.1 19 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.0389109714563403 0.108611594199898 1.0822645927672 0.276785714285714 19.1 19 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0619052355495308 0.150841010594148 1.07013734945266 0.273684210526316 19.1 19 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0204144615234318 0.0694970783441232 1.06860346887533 0.273291925465839 19.1 19 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.135522520844461 0.274713030144826 1.06639561046856 0.272727272727273 19.1 19 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.215580624326054 0.374439089911604 1.06639561046856 0.272727272727273 19.1 19 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.282211684585921 0.456868290290974 1.06639561046856 0.272727272727273 19.1 19 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.282211684585921 0.456868290290974 1.06639561046856 0.272727272727273 19.1 19 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.282211684585921 0.456868290290974 1.06639561046856 0.272727272727273 19.1 19 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.022635080835596 0.073942195889697 1.06200715116622 0.271604938271605 19.1 19 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0866176832188097 0.199122719257457 1.06200715116622 0.271604938271605 19.1 19 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.163462788210076 0.316105655498381 1.05899008539586 0.270833333333333 19.1 19 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.206885368268491 0.367015835628316 1.05678844280668 0.27027027027027 19.1 19 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.206885368268491 0.367015835628316 1.05678844280668 0.27027027027027 19.1 19 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.206885368268491 0.367015835628316 1.05678844280668 0.27027027027027 19.1 19 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.126756179267156 0.258946043827201 1.05511100083397 0.26984126984127 19.1 19 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.268297434937 0.442556670626779 1.05272387187281 0.269230769230769 19.1 19 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.268297434937 0.442556670626779 1.05272387187281 0.269230769230769 19.1 19 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0162001627231316 0.0574883579925593 1.05196047530147 0.269035532994924 19.1 19 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.198627294502027 0.360979106100108 1.04905584444468 0.268292682926829 19.1 19 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.198627294502027 0.360979106100108 1.04905584444468 0.268292682926829 19.1 19 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.198627294502027 0.360979106100108 1.04905584444468 0.268292682926829 19.1 19 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.198627294502027 0.360979106100108 1.04905584444468 0.268292682926829 19.1 19 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.049311573021405 0.131405184287377 1.04680304019748 0.267716535433071 19.1 19 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.10216810683258e-05 0.000450955603479675 1.04594115863479 0.267496111975117 19.1 19 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.0164451485454687 0.0582125531845821 1.04269793023592 0.266666666666667 19.1 19 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.14662445701801 0.291405869185234 1.04269793023592 0.266666666666667 19.1 19 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.255543571997998 0.43085130681653 1.04269793023592 0.266666666666667 19.1 19 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0401613758766241 0.111620386469602 1.03428907595983 0.264516129032258 19.1 19 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.103605867797518 0.225085725001324 1.03370915497527 0.264367816091954 19.1 19 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.103605867797518 0.225085725001324 1.03370915497527 0.264367816091954 19.1 19 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.131683334897254 0.267311534320675 1.03183649346263 0.263888888888889 19.1 19 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.341734746044219 0.528574503935787 1.02897822062756 0.263157894736842 19.1 19 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.213215672653391 0.372277180596044 1.02003058392645 0.260869565217391 19.1 19 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.321362421957224 0.507770024412271 1.02003058392645 0.260869565217391 19.1 19 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.151220354587666 0.299702736181405 1.02003058392645 0.260869565217391 19.1 19 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0744319511830875 0.17535871942638 1.01601471548579 0.259842519685039 19.1 19 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.099639552848197 0.221889019879475 1.01512659073449 0.259615384615385 19.1 19 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.195931487525082 0.357908224323738 1.01373409884048 0.259259259259259 19.1 19 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.195931487525082 0.357908224323738 1.01373409884048 0.259259259259259 19.1 19 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.188034166189822 0.346148277474925 1.01123721682363 0.258620689655172 19.1 19 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.188034166189822 0.346148277474925 1.01123721682363 0.258620689655172 19.1 19 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.188034166189822 0.346148277474925 1.01123721682363 0.258620689655172 19.1 19 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.188034166189822 0.346148277474925 1.01123721682363 0.258620689655172 19.1 19 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0736831235663462 0.173882396077795 1.00545871844178 0.257142857142857 19.1 19 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.273147779298797 0.444216331362501 1.00545871844178 0.257142857142857 19.1 19 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.273147779298797 0.444216331362501 1.00545871844178 0.257142857142857 19.1 19 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.148661448152667 0.295042176738139 1.00137148787901 0.25609756097561 19.1 19 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.247889481980407 0.420938822026395 1.00026254935423 0.255813953488372 19.1 19 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0829650212885232 0.191034345135224 0.998935060901205 0.255474452554745 19.1 19 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.216558939562368 0.374439089911604 0.995302569770655 0.254545454545455 19.1 19 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.216558939562368 0.374439089911604 0.995302569770655 0.254545454545455 19.1 19 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.216558939562368 0.374439089911604 0.995302569770655 0.254545454545455 19.1 19 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.216558939562368 0.374439089911604 0.995302569770655 0.254545454545455 19.1 19 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.207451525345664 0.367015835628316 0.994097602979165 0.254237288135593 19.1 19 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.190832596131237 0.350845974541021 0.992119299291644 0.253731343283582 19.1 19 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.169200156507604 0.322090418719886 0.989903098325245 0.253164556962025 19.1 19 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.139819503857433 0.28210531318593 0.987403343026443 0.252525252525253 19.1 19 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0824652967955239 0.1901914381524 0.9836772926754 0.251572327044025 19.1 19 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0824652967955239 0.1901914381524 0.9836772926754 0.251572327044025 19.1 19 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.10962057905004 0.230754562112732 0.977529309596179 0.25 19.1 19 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.192331867880823 0.353146126444401 0.977529309596179 0.25 19.1 19 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.21804492201174 0.376094453360855 0.977529309596179 0.25 19.1 19 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.21804492201174 0.376094453360855 0.977529309596179 0.25 19.1 19 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.238071988451685 0.405720286906285 0.977529309596179 0.25 19.1 19 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.288067429195453 0.464736942430966 0.977529309596179 0.25 19.1 19 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.303466160496073 0.484660321420776 0.977529309596179 0.25 19.1 19 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.33954825251655 0.525764051502775 0.977529309596179 0.25 19.1 19 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.33954825251655 0.525764051502775 0.977529309596179 0.25 19.1 19 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.361201966142515 0.539485366522937 0.977529309596179 0.25 19.1 19 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.361201966142515 0.539485366522937 0.977529309596179 0.25 19.1 19 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.386352637846632 0.565617081950367 0.977529309596179 0.25 19.1 19 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.386352637846632 0.565617081950367 0.977529309596179 0.25 19.1 19 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.118419501029569 0.245642784205651 0.97039405916117 0.248175182481752 19.1 19 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.123182179884289 0.25477942147579 0.963761291151162 0.246478873239437 19.1 19 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.227830759148662 0.392497784828748 0.963362218152756 0.246376811594203 19.1 19 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.248789803156995 0.421461773681434 0.961504238947061 0.245901639344262 19.1 19 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.248789803156995 0.421461773681434 0.961504238947061 0.245901639344262 19.1 19 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.192817319151353 0.353581243753061 0.956730813647324 0.24468085106383 19.1 19 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.200678430364751 0.363625822692898 0.955806436049597 0.244444444444444 19.1 19 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.236908556668841 0.404221674028489 0.951109598526012 0.243243243243243 19.1 19 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.236908556668841 0.404221674028489 0.951109598526012 0.243243243243243 19.1 19 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.107426132045286 0.226689608137267 0.951109598526012 0.243243243243243 19.1 19 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.354067673212753 0.539485366522937 0.947907209305386 0.242424242424242 19.1 19 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.354067673212753 0.539485366522937 0.947907209305386 0.242424242424242 19.1 19 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.354067673212753 0.539485366522937 0.947907209305386 0.242424242424242 19.1 19 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.283405926185723 0.458280264729868 0.943821402368724 0.241379310344828 19.1 19 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.376083910412391 0.55285888896367 0.943821402368724 0.241379310344828 19.1 19 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.376083910412391 0.55285888896367 0.943821402368724 0.241379310344828 19.1 19 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.297244103607284 0.475671093566058 0.941324520351876 0.240740740740741 19.1 19 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.312220103010403 0.497524307484662 0.938428137212332 0.24 19.1 19 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.401278283771589 0.580894199193257 0.938428137212332 0.24 19.1 19 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.26760616081355 0.442556670626779 0.936225254261129 0.23943661971831 19.1 19 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.346358495517672 0.535144559306892 0.930980294853504 0.238095238095238 19.1 19 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.430767864614313 0.617268195700352 0.930980294853504 0.238095238095238 19.1 19 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.430767864614313 0.617268195700352 0.930980294853504 0.238095238095238 19.1 19 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.430767864614313 0.617268195700352 0.930980294853504 0.238095238095238 19.1 19 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.292957003097259 0.471581239148642 0.930980294853504 0.238095238095238 19.1 19 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.160585779574277 0.311751110960704 0.929844953030512 0.23780487804878 19.1 19 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.275937006806818 0.448240137769523 0.926080398564801 0.236842105263158 19.1 19 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.322218082954519 0.507770024412271 0.924209529072751 0.236363636363636 19.1 19 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.322218082954519 0.507770024412271 0.924209529072751 0.236363636363636 19.1 19 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.322218082954519 0.507770024412271 0.924209529072751 0.236363636363636 19.1 19 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.288378580580845 0.464736942430966 0.923222125729725 0.236111111111111 19.1 19 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.288378580580845 0.464736942430966 0.923222125729725 0.236111111111111 19.1 19 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.338663187729227 0.525537313128343 0.920027585502286 0.235294117647059 19.1 19 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.388002395609686 0.56628452200265 0.920027585502286 0.235294117647059 19.1 19 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.388002395609686 0.56628452200265 0.920027585502286 0.235294117647059 19.1 19 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.388002395609686 0.56628452200265 0.920027585502286 0.235294117647059 19.1 19 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.000223455151205119 0.00160594282911558 0.917447020323438 0.234634146341463 19.1 19 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.356571606129616 0.539485366522937 0.915133821749614 0.234042553191489 19.1 19 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.412770100364598 0.596922614653275 0.912360688956434 0.233333333333333 19.1 19 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.199120881281545 0.361414558754641 0.911561073979259 0.233128834355828 19.1 19 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.309648562233487 0.493979713069789 0.910575247295071 0.232876712328767 19.1 19 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.323952303698994 0.509938194871315 0.906693852379064 0.231884057971014 19.1 19 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.35571357983382 0.539485366522937 0.897403956350591 0.229508196721311 19.1 19 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.384954521510949 0.564732251659876 0.896068533796497 0.229166666666667 19.1 19 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.422033393035134 0.608463544365751 0.893741083059364 0.228571428571429 19.1 19 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.338155578772035 0.525322476629483 0.89091278849272 0.227848101265823 19.1 19 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.47446085874031 0.663871978355419 0.888663008723799 0.227272727272727 19.1 19 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.392633093400529 0.572040790853746 0.88530956340786 0.226415094339623 19.1 19 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.449289603786662 0.637426825711286 0.882929698990097 0.225806451612903 19.1 19 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.296050961389757 0.475671093566058 0.881981331966477 0.225563909774436 19.1 19 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.413506241076084 0.597380082285551 0.877781420861875 0.224489795918367 19.1 19 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.375702362710753 0.55285888896367 0.874631487533423 0.223684210526316 19.1 19 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.48050704124621 0.670354431071918 0.86891494186327 0.222222222222222 19.1 19 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.442074126171533 0.629071481542091 0.860225792444637 0.22 19.1 19 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.485352077362696 0.672134852381321 0.855338145896656 0.21875 19.1 19 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.485352077362696 0.672134852381321 0.855338145896656 0.21875 19.1 19 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.378799225767964 0.556275849605586 0.85431132939498 0.218487394957983 19.1 19 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.516988202291167 0.690125902308003 0.850025486605373 0.217391304347826 19.1 19 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.516988202291167 0.690125902308003 0.850025486605373 0.217391304347826 19.1 19 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.423426038336584 0.609853494486801 0.840492490493911 0.214953271028037 19.1 19 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.44715152477075 0.635026566615546 0.837882265368153 0.214285714285714 19.1 19 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.44715152477075 0.635026566615546 0.837882265368153 0.214285714285714 19.1 19 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.477672220506819 0.667053552287737 0.83330367375412 0.213114754098361 19.1 19 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.52229174225837 0.696552154858164 0.823182576502045 0.210526315789474 19.1 19 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.4769501763989 0.666699509838542 0.82112462006079 0.21 19.1 19 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.481477323951886 0.671050178240484 0.817569968025895 0.209090909090909 19.1 19 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.557984580225023 0.742761513246219 0.814607757996816 0.208333333333333 19.1 19 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.555100411075993 0.739614124495448 0.8050241373145 0.205882352941176 19.1 19 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.597161154338382 0.7630149756004 0.782023447676943 0.2 19.1 19 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.611885109411542 0.777421884546985 0.765022937944836 0.195652173913043 19.1 19 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.626352535397921 0.793677344497989 0.756796884848655 0.193548387096774 19.1 19 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.628363168321957 0.795516715767033 0.756796884848655 0.193548387096774 19.1 19 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.634301300985147 0.798465786806071 0.751945622766292 0.192307692307692 19.1 19 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.670218546442759 0.836250783024236 0.73668875505799 0.188405797101449 19.1 19 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.669254541834906 0.836250783024236 0.724095784886059 0.185185185185185 19.1 19 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.679931241011273 0.836250783024236 0.72028475443929 0.184210526315789 19.1 19 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.711567041374372 0.868404716874555 0.715936959140863 0.183098591549296 19.1 19 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.836997092258485 0.98262819835117 0.693730477777933 0.17741935483871 19.1 19 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.780026617673266 0.929629712687653 0.651686206397453 0.166666666666667 19.1 19 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.842593748896559 0.985218491930816 0.643437013911409 0.164556962025316 19.1 19 1 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.786090319208463 0.936072405216437 0.630664070707212 0.161290322580645 19.1 19 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.992050417316019 1 0.614734926653267 0.157216494845361 19.1 19 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.831082340698923 0.978069257530217 0.592442005815866 0.151515151515152 19.1 19 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.868035896928594 1 0.558588176912102 0.142857142857143 19.1 19 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.991845851359143 1 0.558588176912102 0.142857142857143 19.1 19 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.968431217004269 1 0.543071838664544 0.138888888888889 19.1 19 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999329413271107 1 0.516694063643695 0.132142857142857 19.1 19 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.935320404103416 1 0.516430578654585 0.132075471698113 19.1 19 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999999951 1 0.482608928667131 0.123425692695214 19.1 19 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.993158543042188 1 0.434457470931635 0.111111111111111 19.1 19 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.424244184996533 0.108499095840868 19.1 19 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.978437906214639 1 0.407303878998408 0.104166666666667 19.1 19 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999994754393808 1 0.333248628271425 0.0852272727272727 19.1 19 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 1.14288004477983e-05 5.05067796186862e-05 2.11944827586207 1 19.3 19 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 3.56716148708889e-05 0.000151978167548727 2.11944827586207 1 19.3 19 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000347444572359717 0.00117998478870615 2.11944827586207 1 19.3 19 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.000347444572359717 0.00117998478870615 2.11944827586207 1 19.3 19 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00108424188106513 0.00331089312608514 2.11944827586207 1 19.3 19 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00108424188106513 0.00331089312608514 2.11944827586207 1 19.3 19 3 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.00338329350173395 0.0087376164300679 2.11944827586207 1 19.3 19 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 1.26557872869554e-06 6.40896274353651e-06 1.97815172413793 0.933333333333333 19.3 19 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 1.26557872869554e-06 6.40896274353651e-06 1.97815172413793 0.933333333333333 19.3 19 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 1.07394765148716e-05 4.76083335846178e-05 1.95641379310345 0.923076923076923 19.3 19 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 3.10349099375683e-05 0.000132620651174654 1.9428275862069 0.916666666666667 19.3 19 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 3.10349099375683e-05 0.000132620651174654 1.9428275862069 0.916666666666667 19.3 19 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 8.9102451895962e-05 0.000356159519797623 1.92677115987461 0.909090909090909 19.3 19 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000253856944678703 0.000912218263327765 1.90750344827586 0.9 19.3 19 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000253856944678703 0.000912218263327765 1.90750344827586 0.9 19.3 19 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.000253856944678703 0.000912218263327765 1.90750344827586 0.9 19.3 19 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 9.22376326392232e-07 4.79029749071586e-06 1.88395402298851 0.888888888888889 19.3 19 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.000716609818646729 0.00224117752073472 1.88395402298851 0.888888888888889 19.3 19 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.000716609818646729 0.00224117752073472 1.88395402298851 0.888888888888889 19.3 19 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 7.10368974790256e-06 3.17180215664175e-05 1.85451724137931 0.875 19.3 19 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 7.10368974790256e-06 3.17180215664175e-05 1.85451724137931 0.875 19.3 19 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 7.10368974790256e-06 3.17180215664175e-05 1.85451724137931 0.875 19.3 19 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 7.10368974790256e-06 3.17180215664175e-05 1.85451724137931 0.875 19.3 19 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 7.10368974790256e-06 3.17180215664175e-05 1.85451724137931 0.875 19.3 19 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 7.10368974790256e-06 3.17180215664175e-05 1.85451724137931 0.875 19.3 19 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00200023667184475 0.0056363104634358 1.85451724137931 0.875 19.3 19 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00200023667184475 0.0056363104634358 1.85451724137931 0.875 19.3 19 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00200023667184475 0.0056363104634358 1.85451724137931 0.875 19.3 19 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00200023667184475 0.0056363104634358 1.85451724137931 0.875 19.3 19 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00200023667184475 0.0056363104634358 1.85451724137931 0.875 19.3 19 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00200023667184475 0.0056363104634358 1.85451724137931 0.875 19.3 19 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 7.72971743950982e-08 4.76163979065908e-07 1.84299850074963 0.869565217391304 19.3 19 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 2.10623724622832e-07 1.19409386509279e-06 1.83043260188088 0.863636363636364 19.3 19 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 5.30025276362524e-05 0.000216731600075825 1.81666995073892 0.857142857142857 19.3 19 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 5.30025276362524e-05 0.000216731600075825 1.81666995073892 0.857142857142857 19.3 19 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 5.30025276362524e-05 0.000216731600075825 1.81666995073892 0.857142857142857 19.3 19 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.00550502573329759 0.013576519269467 1.81666995073892 0.857142857142857 19.3 19 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00550502573329759 0.013576519269467 1.81666995073892 0.857142857142857 19.3 19 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00550502573329759 0.013576519269467 1.81666995073892 0.857142857142857 19.3 19 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00550502573329759 0.013576519269467 1.81666995073892 0.857142857142857 19.3 19 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00550502573329759 0.013576519269467 1.81666995073892 0.857142857142857 19.3 19 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.53246367005015e-06 7.67850634676535e-06 1.80153103448276 0.85 19.3 19 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0001426597937624 0.000545712060548104 1.79337931034483 0.846153846153846 19.3 19 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 4.08625012127539e-06 1.93824464085829e-05 1.78479854809437 0.842105263157895 19.3 19 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.22528997639755e-07 7.2348034705963e-07 1.78033655172414 0.84 19.3 19 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 9.91484899254044e-09 8.01638074794605e-08 1.76620689655172 0.833333333333333 19.3 19 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00037944016168793 0.00128252577216609 1.76620689655172 0.833333333333333 19.3 19 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00037944016168793 0.00128252577216609 1.76620689655172 0.833333333333333 19.3 19 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0148785516050781 0.0322255387123686 1.76620689655172 0.833333333333333 19.3 19 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0148785516050781 0.0322255387123686 1.76620689655172 0.833333333333333 19.3 19 3 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0148785516050781 0.0322255387123686 1.76620689655172 0.833333333333333 19.3 19 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 8.43924838204571e-07 4.46433102143162e-06 1.75084857571214 0.826086956521739 19.3 19 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 2.82669856717221e-05 0.000121522418763929 1.74542799188641 0.823529411764706 19.3 19 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.47243735725404e-14 4.76199627130115e-13 1.74097536945813 0.821428571428571 19.3 19 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.41610824922944e-11 2.55078739070063e-10 1.73409404388715 0.818181818181818 19.3 19 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000995252162201043 0.00307879092785236 1.73409404388715 0.818181818181818 19.3 19 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.000995252162201043 0.00307879092785236 1.73409404388715 0.818181818181818 19.3 19 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 7.63600492787158e-12 1.4297414489949e-10 1.71359647835657 0.808510638297872 19.3 19 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 4.43165540896552e-07 2.37971533847469e-06 1.71186206896552 0.807692307692308 19.3 19 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.43165540896552e-07 2.37971533847469e-06 1.71186206896552 0.807692307692308 19.3 19 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 4.88286301584719e-11 8.07943496691925e-10 1.69555862068966 0.8 19.3 19 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.12384251029403e-06 5.75261831708061e-06 1.69555862068966 0.8 19.3 19 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 1.43013959261764e-05 6.26181120090739e-05 1.69555862068966 0.8 19.3 19 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 1.43013959261764e-05 6.26181120090739e-05 1.69555862068966 0.8 19.3 19 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0001870486452881 0.000707899527247252 1.69555862068966 0.8 19.3 19 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0001870486452881 0.000707899527247252 1.69555862068966 0.8 19.3 19 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00256762131451883 0.00697275788274865 1.69555862068966 0.8 19.3 19 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00256762131451883 0.00697275788274865 1.69555862068966 0.8 19.3 19 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00256762131451883 0.00697275788274865 1.69555862068966 0.8 19.3 19 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00256762131451883 0.00697275788274865 1.69555862068966 0.8 19.3 19 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 2.82423076273361e-06 1.38105854823709e-05 1.67789655172414 0.791666666666667 19.3 19 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 5.62156667601e-07 2.98488409700083e-06 1.66528078817734 0.785714285714286 19.3 19 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000471403102891605 0.00156365178418358 1.66528078817734 0.785714285714286 19.3 19 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000471403102891605 0.00156365178418358 1.66528078817734 0.785714285714286 19.3 19 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 7.027433279529e-06 3.17180215664175e-05 1.65869865067466 0.782608695652174 19.3 19 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.12590856265299e-07 6.67569951939669e-07 1.65581896551724 0.78125 19.3 19 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.38770239200404e-06 6.97774029618992e-06 1.64845977011494 0.777777777777778 19.3 19 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 8.94003681858484e-05 0.000356349366746393 1.64845977011494 0.777777777777778 19.3 19 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00649293065803782 0.0155808437207214 1.64845977011494 0.777777777777778 19.3 19 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00649293065803782 0.0155808437207214 1.64845977011494 0.777777777777778 19.3 19 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00649293065803782 0.0155808437207214 1.64845977011494 0.777777777777778 19.3 19 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.00649293065803782 0.0155808437207214 1.64845977011494 0.777777777777778 19.3 19 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00649293065803782 0.0155808437207214 1.64845977011494 0.777777777777778 19.3 19 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00649293065803782 0.0155808437207214 1.64845977011494 0.777777777777778 19.3 19 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00649293065803782 0.0155808437207214 1.64845977011494 0.777777777777778 19.3 19 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2.76262318863971e-07 1.55383905036929e-06 1.64086318131257 0.774193548387097 19.3 19 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 1.7297840326202e-05 7.52746996458271e-05 1.63775548589342 0.772727272727273 19.3 19 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00116870805477303 0.00352345669902971 1.63034482758621 0.769230769230769 19.3 19 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00116870805477303 0.00352345669902971 1.63034482758621 0.769230769230769 19.3 19 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00116870805477303 0.00352345669902971 1.63034482758621 0.769230769230769 19.3 19 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00116870805477303 0.00352345669902971 1.63034482758621 0.769230769230769 19.3 19 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000219101970104282 0.000822644072449588 1.62075456389452 0.764705882352941 19.3 19 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000219101970104282 0.000822644072449588 1.62075456389452 0.764705882352941 19.3 19 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 4.20748781198933e-05 0.00017819211775181 1.61481773399015 0.761904761904762 19.3 19 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.61956441986329e-06 8.08645673496654e-06 1.60785731272295 0.758620689655172 19.3 19 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.29804437461421e-08 1.03770626127866e-07 1.60250967199327 0.75609756097561 19.3 19 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.29804437461421e-08 1.03770626127866e-07 1.60250967199327 0.75609756097561 19.3 19 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.62252702231827e-09 2.64670634947439e-08 1.60136091954023 0.755555555555556 19.3 19 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.34059525874818e-16 1.32046307033296e-14 1.59581987829615 0.752941176470588 19.3 19 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.17357817336388e-12 4.48261121840117e-11 1.58958620689655 0.75 19.3 19 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 3.86433956521316e-06 1.84528698030145e-05 1.58958620689655 0.75 19.3 19 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0160193929176561 0.0336218231885319 1.58958620689655 0.75 19.3 19 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.84109503655955e-15 1.30139958024387e-13 1.58958620689655 0.75 19.3 19 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.53385711316418e-07 8.94540439357633e-07 1.58958620689655 0.75 19.3 19 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.53385711316418e-07 8.94540439357633e-07 1.58958620689655 0.75 19.3 19 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.000101007854516948 0.000398155614896444 1.58958620689655 0.75 19.3 19 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000101007854516948 0.000398155614896444 1.58958620689655 0.75 19.3 19 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00284268816374038 0.00743536740082349 1.58958620689655 0.75 19.3 19 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00284268816374038 0.00743536740082349 1.58958620689655 0.75 19.3 19 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00284268816374038 0.00743536740082349 1.58958620689655 0.75 19.3 19 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00284268816374038 0.00743536740082349 1.58958620689655 0.75 19.3 19 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00284268816374038 0.00743536740082349 1.58958620689655 0.75 19.3 19 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00284268816374038 0.00743536740082349 1.58958620689655 0.75 19.3 19 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00284268816374038 0.00743536740082349 1.58958620689655 0.75 19.3 19 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00284268816374038 0.00743536740082349 1.58958620689655 0.75 19.3 19 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.96812324584277e-09 2.95359397121277e-08 1.57831254585473 0.74468085106383 19.3 19 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00023898296949939 0.000881017527455005 1.56169872958258 0.736842105263158 19.3 19 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00023898296949939 0.000881017527455005 1.56169872958258 0.736842105263158 19.3 19 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00023898296949939 0.000881017527455005 1.56169872958258 0.736842105263158 19.3 19 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 6.46402152810562e-11 9.7007737273387e-10 1.55426206896552 0.733333333333333 19.3 19 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 6.46402152810562e-11 9.7007737273387e-10 1.55426206896552 0.733333333333333 19.3 19 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 6.46402152810562e-11 9.7007737273387e-10 1.55426206896552 0.733333333333333 19.3 19 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 6.46402152810562e-11 9.7007737273387e-10 1.55426206896552 0.733333333333333 19.3 19 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 6.46402152810562e-11 9.7007737273387e-10 1.55426206896552 0.733333333333333 19.3 19 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 6.46402152810562e-11 9.7007737273387e-10 1.55426206896552 0.733333333333333 19.3 19 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 6.46402152810562e-11 9.7007737273387e-10 1.55426206896552 0.733333333333333 19.3 19 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 6.46402152810562e-11 9.7007737273387e-10 1.55426206896552 0.733333333333333 19.3 19 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.22532815124401e-06 1.99755546817948e-05 1.55426206896552 0.733333333333333 19.3 19 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00125337786130124 0.00368232164515236 1.55426206896552 0.733333333333333 19.3 19 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00125337786130124 0.00368232164515236 1.55426206896552 0.733333333333333 19.3 19 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00125337786130124 0.00368232164515236 1.55426206896552 0.733333333333333 19.3 19 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00125337786130124 0.00368232164515236 1.55426206896552 0.733333333333333 19.3 19 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 2.12808690749295e-05 9.20446100110172e-05 1.5488275862069 0.730769230769231 19.3 19 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.05584917215366e-11 5.43559171496833e-10 1.54753366174056 0.73015873015873 19.3 19 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00676060572069957 0.01598063445275 1.54141692789969 0.727272727272727 19.3 19 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00676060572069957 0.01598063445275 1.54141692789969 0.727272727272727 19.3 19 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00676060572069957 0.01598063445275 1.54141692789969 0.727272727272727 19.3 19 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00676060572069957 0.01598063445275 1.54141692789969 0.727272727272727 19.3 19 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00676060572069957 0.01598063445275 1.54141692789969 0.727272727272727 19.3 19 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.82887336931144e-07 1.04938984053636e-06 1.5366 0.725 19.3 19 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.82887336931144e-07 1.04938984053636e-06 1.5366 0.725 19.3 19 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.7336638989642e-08 1.32634609044412e-07 1.53321790168745 0.723404255319149 19.3 19 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 9.02955177388044e-07 4.72391624052642e-06 1.53071264367816 0.722222222222222 19.3 19 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 9.02955177388044e-07 4.72391624052642e-06 1.53071264367816 0.722222222222222 19.3 19 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000556326135092213 0.00177899346120499 1.53071264367816 0.722222222222222 19.3 19 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000556326135092213 0.00177899346120499 1.53071264367816 0.722222222222222 19.3 19 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000556326135092213 0.00177899346120499 1.53071264367816 0.722222222222222 19.3 19 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.03947194169752e-14 8.31763187122225e-13 1.52797433841219 0.720930232558139 19.3 19 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 3.9421294750967e-08 2.50430814422438e-07 1.52047376311844 0.717391304347826 19.3 19 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00291197043447659 0.00757538195294368 1.51389162561576 0.714285714285714 19.3 19 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00291197043447659 0.00757538195294368 1.51389162561576 0.714285714285714 19.3 19 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0383123662845293 0.0721144143159857 1.51389162561576 0.714285714285714 19.3 19 3 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0383123662845293 0.0721144143159857 1.51389162561576 0.714285714285714 19.3 19 3 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0383123662845293 0.0721144143159857 1.51389162561576 0.714285714285714 19.3 19 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0383123662845293 0.0721144143159857 1.51389162561576 0.714285714285714 19.3 19 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.8286439679338e-08 1.39152960768438e-07 1.51389162561576 0.714285714285714 19.3 19 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000248340295509584 0.000903806241713906 1.51389162561576 0.714285714285714 19.3 19 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000248340295509584 0.000903806241713906 1.51389162561576 0.714285714285714 19.3 19 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000248340295509584 0.000903806241713906 1.51389162561576 0.714285714285714 19.3 19 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.68831809226738e-10 2.33250159737522e-09 1.51389162561576 0.714285714285714 19.3 19 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 8.47977529282332e-09 7.18257157243309e-08 1.50806896551724 0.711538461538462 19.3 19 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.66892456343678e-11 6.29021645032595e-10 1.50511544227886 0.710144927536232 19.3 19 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.93141119513972e-09 3.75462961790861e-08 1.50288150470219 0.709090909090909 19.3 19 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.93141119513972e-09 3.75462961790861e-08 1.50288150470219 0.709090909090909 19.3 19 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00011138659327058 0.000430944422380913 1.50127586206897 0.708333333333333 19.3 19 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00011138659327058 0.000430944422380913 1.50127586206897 0.708333333333333 19.3 19 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00011138659327058 0.000430944422380913 1.50127586206897 0.708333333333333 19.3 19 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.51977329081184e-19 9.8301699673875e-18 1.49991724137931 0.707692307692308 19.3 19 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 4.32738844007679e-07 2.35933860162041e-06 1.49912195121951 0.707317073170732 19.3 19 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.47519090931903e-15 1.20614552779536e-13 1.49859979101358 0.707070707070707 19.3 19 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.82246367144059e-09 1.94618332274906e-08 1.49823067776457 0.706896551724138 19.3 19 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 4.61682703823904e-06 2.13303405045914e-05 1.49608113590264 0.705882352941177 19.3 19 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 4.61682703823904e-06 2.13303405045914e-05 1.49608113590264 0.705882352941177 19.3 19 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 4.61682703823904e-06 2.13303405045914e-05 1.49608113590264 0.705882352941177 19.3 19 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00127168963117818 0.00368232164515236 1.49608113590264 0.705882352941177 19.3 19 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00127168963117818 0.00368232164515236 1.49608113590264 0.705882352941177 19.3 19 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00127168963117818 0.00368232164515236 1.49608113590264 0.705882352941177 19.3 19 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00127168963117818 0.00368232164515236 1.49608113590264 0.705882352941177 19.3 19 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00127168963117818 0.00368232164515236 1.49608113590264 0.705882352941177 19.3 19 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00127168963117818 0.00368232164515236 1.49608113590264 0.705882352941177 19.3 19 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00127168963117818 0.00368232164515236 1.49608113590264 0.705882352941177 19.3 19 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.8967138864622e-08 1.42805495261149e-07 1.49608113590264 0.705882352941177 19.3 19 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 3.53963528999647e-16 1.36132459936891e-14 1.49146360153257 0.703703703703704 19.3 19 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 8.76243089360432e-09 7.37807050982187e-08 1.49146360153257 0.703703703703704 19.3 19 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 5.01593274762979e-05 0.000206889052170353 1.49146360153257 0.703703703703704 19.3 19 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 5.01593274762979e-05 0.000206889052170353 1.49146360153257 0.703703703703704 19.3 19 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 5.01593274762979e-05 0.000206889052170353 1.49146360153257 0.703703703703704 19.3 19 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 2.10746469577327e-06 1.03411112485702e-05 1.48934203168686 0.702702702702703 19.3 19 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.70720785719223e-17 3.22569317081898e-15 1.48733212341198 0.701754385964912 19.3 19 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.44138804964582e-36 2.93013599235142e-34 1.48604994054697 0.701149425287356 19.3 19 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 8.41390629503865e-11 1.20939279372121e-09 1.48361379310345 0.7 19.3 19 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.87145701499941e-09 1.97265432025494e-08 1.48361379310345 0.7 19.3 19 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 2.26638153862859e-05 9.77291190748026e-05 1.48361379310345 0.7 19.3 19 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000560924904458419 0.00178567368913721 1.48361379310345 0.7 19.3 19 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000560924904458419 0.00178567368913721 1.48361379310345 0.7 19.3 19 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0156519857929154 0.0333424787175429 1.48361379310345 0.7 19.3 19 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0156519857929154 0.0333424787175429 1.48361379310345 0.7 19.3 19 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0156519857929154 0.0333424787175429 1.48361379310345 0.7 19.3 19 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0156519857929154 0.0333424787175429 1.48361379310345 0.7 19.3 19 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0156519857929154 0.0333424787175429 1.48361379310345 0.7 19.3 19 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0156519857929154 0.0333424787175429 1.48361379310345 0.7 19.3 19 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0156519857929154 0.0333424787175429 1.48361379310345 0.7 19.3 19 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0156519857929154 0.0333424787175429 1.48361379310345 0.7 19.3 19 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.90047243968335e-11 6.52984974314048e-10 1.4807104393009 0.698630136986301 19.3 19 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.93865931572202e-08 1.43482269533642e-07 1.47961483409239 0.69811320754717 19.3 19 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 4.40953653029931e-07 2.37971533847469e-06 1.4786848436247 0.697674418604651 19.3 19 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 4.40953653029931e-07 2.37971533847469e-06 1.4786848436247 0.697674418604651 19.3 19 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 8.0175451220659e-16 2.92537607915379e-14 1.47778044922493 0.697247706422018 19.3 19 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 8.9324390758745e-09 7.40033529154352e-08 1.47604433497537 0.696428571428571 19.3 19 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.02067840515263e-07 1.15017014821287e-06 1.4743988005997 0.695652173913043 19.3 19 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.02067840515263e-07 1.15017014821287e-06 1.4743988005997 0.695652173913043 19.3 19 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00024928904049079 0.000904944654638762 1.4743988005997 0.695652173913043 19.3 19 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.11783223549973e-09 3.80166731967606e-08 1.47283693746347 0.694915254237288 19.3 19 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.11783223549973e-09 3.80166731967606e-08 1.47283693746347 0.694915254237288 19.3 19 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.89924801793306e-09 1.98096324867345e-08 1.46993993325918 0.693548387096774 19.3 19 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000111445922302302 0.000430944422380913 1.46731034482759 0.692307692307692 19.3 19 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000111445922302302 0.000430944422380913 1.46731034482759 0.692307692307692 19.3 19 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00660914340891693 0.0157534523800482 1.46731034482759 0.692307692307692 19.3 19 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00660914340891693 0.0157534523800482 1.46731034482759 0.692307692307692 19.3 19 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00660914340891693 0.0157534523800482 1.46731034482759 0.692307692307692 19.3 19 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00660914340891693 0.0157534523800482 1.46731034482759 0.692307692307692 19.3 19 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.9561180807819e-08 1.43482269533642e-07 1.4643460815047 0.690909090909091 19.3 19 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.9561180807819e-08 1.43482269533642e-07 1.4643460815047 0.690909090909091 19.3 19 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.9561180807819e-08 1.43482269533642e-07 1.4643460815047 0.690909090909091 19.3 19 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.9561180807819e-08 1.43482269533642e-07 1.4643460815047 0.690909090909091 19.3 19 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 9.68494228281186e-07 4.97533316550226e-06 1.46342857142857 0.69047619047619 19.3 19 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 8.99689392436422e-09 7.40033529154352e-08 1.46168846611177 0.689655172413793 19.3 19 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 8.99689392436422e-09 7.40033529154352e-08 1.46168846611177 0.689655172413793 19.3 19 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 8.99689392436422e-09 7.40033529154352e-08 1.46168846611177 0.689655172413793 19.3 19 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 5.00591099166183e-05 0.000206889052170353 1.46168846611177 0.689655172413793 19.3 19 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 5.00591099166183e-05 0.000206889052170353 1.46168846611177 0.689655172413793 19.3 19 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 5.00591099166183e-05 0.000206889052170353 1.46168846611177 0.689655172413793 19.3 19 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 8.43095057631824e-13 1.90432423334934e-11 1.46006436781609 0.688888888888889 19.3 19 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 4.14095878109479e-09 3.80166731967606e-08 1.45929225551159 0.688524590163934 19.3 19 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.14095878109479e-09 3.80166731967606e-08 1.45929225551159 0.688524590163934 19.3 19 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 8.23241507236711e-23 6.89101567528141e-21 1.45867910750507 0.688235294117647 19.3 19 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.90718176435884e-09 1.98096324867345e-08 1.45712068965517 0.6875 19.3 19 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00284769868829853 0.00743536740082349 1.45712068965517 0.6875 19.3 19 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00284769868829853 0.00743536740082349 1.45712068965517 0.6875 19.3 19 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00284769868829853 0.00743536740082349 1.45712068965517 0.6875 19.3 19 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00284769868829853 0.00743536740082349 1.45712068965517 0.6875 19.3 19 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00284769868829853 0.00743536740082349 1.45712068965517 0.6875 19.3 19 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00284769868829853 0.00743536740082349 1.45712068965517 0.6875 19.3 19 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 8.78903256692191e-10 9.92602646248403e-09 1.45514359238291 0.686567164179104 19.3 19 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 8.78903256692191e-10 9.92602646248403e-09 1.45514359238291 0.686567164179104 19.3 19 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 8.78903256692191e-10 9.92602646248403e-09 1.45514359238291 0.686567164179104 19.3 19 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.78159876307949e-22 1.4084527999234e-20 1.45476923076923 0.686390532544379 19.3 19 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.27020603684919e-08 5.63739452582752e-07 1.45452332657201 0.686274509803922 19.3 19 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.27020603684919e-08 5.63739452582752e-07 1.45452332657201 0.686274509803922 19.3 19 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 4.25097698486197e-08 2.64154596046227e-07 1.45221455938697 0.685185185185185 19.3 19 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.84519836695182e-23 3.62872968549012e-21 1.44888836937463 0.68361581920904 19.3 19 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.10628910540154e-06 1.03411112485702e-05 1.44742809083263 0.682926829268293 19.3 19 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.10628910540154e-06 1.03411112485702e-05 1.44742809083263 0.682926829268293 19.3 19 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 3.66412897021465e-37 8.69009254102575e-35 1.4467223726021 0.68259385665529 19.3 19 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 4.12244225813524e-09 3.80166731967606e-08 1.44660755336617 0.682539682539683 19.3 19 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.84362272401494e-17 1.65741670796159e-15 1.44582518043304 0.682170542635659 19.3 19 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000548754545380685 0.00176669166985682 1.44507836990596 0.681818181818182 19.3 19 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000548754545380685 0.00176669166985682 1.44507836990596 0.681818181818182 19.3 19 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000548754545380685 0.00176669166985682 1.44507836990596 0.681818181818182 19.3 19 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 8.73515628458918e-10 9.92602646248403e-09 1.44368215892054 0.681159420289855 19.3 19 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.82958986023538e-21 2.72475318555747e-19 1.44330526761159 0.680981595092024 19.3 19 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 8.23220538079311e-27 9.01109865912969e-25 1.44324334975369 0.680952380952381 19.3 19 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.02474449978321e-10 5.35253404036589e-09 1.44240229885057 0.680555555555556 19.3 19 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.85543600821338e-10 2.53873599969965e-09 1.44122482758621 0.68 19.3 19 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000243907183922285 0.000894535883302606 1.44122482758621 0.68 19.3 19 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000243907183922285 0.000894535883302606 1.44122482758621 0.68 19.3 19 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000109048482271052 0.000427482066864206 1.43819704433498 0.678571428571429 19.3 19 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.671373245247e-32 5.80484903109608e-30 1.43470344827586 0.676923076923077 19.3 19 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 3.72578970529931e-20 2.52466607173377e-18 1.4306275862069 0.675 19.3 19 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 4.53329218791004e-06 2.11504091258885e-05 1.4306275862069 0.675 19.3 19 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 4.53329218791004e-06 2.11504091258885e-05 1.4306275862069 0.675 19.3 19 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 9.39126870478238e-07 4.84194759670483e-06 1.42832383808096 0.673913043478261 19.3 19 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.76791690960827e-12 3.75484442145158e-11 1.4278388384755 0.673684210526316 19.3 19 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.88551186761646e-08 1.42717201469054e-07 1.42454720180893 0.672131147540984 19.3 19 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.97946762408583e-09 3.77518828604942e-08 1.42351003602676 0.671641791044776 19.3 19 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.55065564284288e-50 9.07395744941353e-48 1.4229159786304 0.671361502347418 19.3 19 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.42504433399971e-10 9.92602646248403e-09 1.42264336324988 0.671232876712329 19.3 19 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 7.99179835586366e-13 1.83424662264419e-11 1.42003034482759 0.67 19.3 19 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 3.865055430683e-09 3.74147882847749e-08 1.41296551724138 0.666666666666667 19.3 19 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.865055430683e-09 3.74147882847749e-08 1.41296551724138 0.666666666666667 19.3 19 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00023401911195431 0.00086947570838377 1.41296551724138 0.666666666666667 19.3 19 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00023401911195431 0.00086947570838377 1.41296551724138 0.666666666666667 19.3 19 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00023401911195431 0.00086947570838377 1.41296551724138 0.666666666666667 19.3 19 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00023401911195431 0.00086947570838377 1.41296551724138 0.666666666666667 19.3 19 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.77828446187357e-09 1.91704453730764e-08 1.41296551724138 0.666666666666667 19.3 19 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.77828446187357e-09 1.91704453730764e-08 1.41296551724138 0.666666666666667 19.3 19 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 9.09204834845295e-07 4.73918857137309e-06 1.41296551724138 0.666666666666667 19.3 19 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.99411103184529e-06 9.88717769448028e-06 1.41296551724138 0.666666666666667 19.3 19 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000525093934931211 0.0017020698619752 1.41296551724138 0.666666666666667 19.3 19 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000525093934931211 0.0017020698619752 1.41296551724138 0.666666666666667 19.3 19 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000525093934931211 0.0017020698619752 1.41296551724138 0.666666666666667 19.3 19 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000525093934931211 0.0017020698619752 1.41296551724138 0.666666666666667 19.3 19 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00118609412235609 0.00354582339519479 1.41296551724138 0.666666666666667 19.3 19 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00118609412235609 0.00354582339519479 1.41296551724138 0.666666666666667 19.3 19 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00118609412235609 0.00354582339519479 1.41296551724138 0.666666666666667 19.3 19 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00118609412235609 0.00354582339519479 1.41296551724138 0.666666666666667 19.3 19 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00270241662335011 0.00726944963143138 1.41296551724138 0.666666666666667 19.3 19 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00270241662335011 0.00726944963143138 1.41296551724138 0.666666666666667 19.3 19 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00270241662335011 0.00726944963143138 1.41296551724138 0.666666666666667 19.3 19 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00270241662335011 0.00726944963143138 1.41296551724138 0.666666666666667 19.3 19 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00622915558082728 0.0151522878487474 1.41296551724138 0.666666666666667 19.3 19 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00622915558082728 0.0151522878487474 1.41296551724138 0.666666666666667 19.3 19 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.014596440834618 0.0318081704558367 1.41296551724138 0.666666666666667 19.3 19 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.014596440834618 0.0318081704558367 1.41296551724138 0.666666666666667 19.3 19 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.014596440834618 0.0318081704558367 1.41296551724138 0.666666666666667 19.3 19 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.014596440834618 0.0318081704558367 1.41296551724138 0.666666666666667 19.3 19 3 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0350723174368928 0.0667218017549444 1.41296551724138 0.666666666666667 19.3 19 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0350723174368928 0.0667218017549444 1.41296551724138 0.666666666666667 19.3 19 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0350723174368928 0.0667218017549444 1.41296551724138 0.666666666666667 19.3 19 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0350723174368928 0.0667218017549444 1.41296551724138 0.666666666666667 19.3 19 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 4.15234579318621e-07 2.2726107937323e-06 1.41296551724138 0.666666666666667 19.3 19 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.4216609631905e-31 2.02302355062008e-29 1.41036815415821 0.665441176470588 19.3 19 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.48406518473786e-13 8.40309280996944e-12 1.40636287463745 0.663551401869159 19.3 19 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.52604774970184e-12 6.87337801072015e-11 1.40575650950035 0.663265306122449 19.3 19 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 7.75265119328046e-11 1.12571659673858e-09 1.40475060144346 0.662790697674419 19.3 19 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.83917500566236e-08 2.45059455264421e-07 1.40157063403782 0.661290322580645 19.3 19 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 8.36691647194632e-08 5.13194919809466e-07 1.40099123319696 0.661016949152542 19.3 19 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.98701415523935e-07 2.19903920267659e-06 1.39963565387118 0.660377358490566 19.3 19 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.45294979490351e-18 7.38409842195604e-17 1.39963565387118 0.660377358490566 19.3 19 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.39805151632312e-12 6.71587126073306e-11 1.39883586206897 0.66 19.3 19 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 8.72011863734743e-07 4.59582548923903e-06 1.39883586206897 0.66 19.3 19 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.45738631816783e-11 1.09400626090235e-09 1.39690909090909 0.659090909090909 19.3 19 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.5012960834259e-10 4.74508983496672e-09 1.39573423044575 0.658536585365854 19.3 19 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.40385028368542e-17 6.24274673026358e-16 1.39437386569873 0.657894736842105 19.3 19 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 3.57498211654289e-09 3.50841348402796e-08 1.39360982522437 0.657534246575342 19.3 19 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 4.48549695128199e-05 0.000188285019518415 1.3927802955665 0.657142857142857 19.3 19 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 4.48549695128199e-05 0.000188285019518415 1.3927802955665 0.657142857142857 19.3 19 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.68766319870809e-08 1.29813228743871e-07 1.39187647967061 0.656716417910448 19.3 19 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 7.04991099303198e-12 1.33760311241127e-10 1.39155694879833 0.656565656565657 19.3 19 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 6.24343347969602e-18 2.96146861386914e-16 1.39046606632989 0.656050955414013 19.3 19 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.54541553317347e-10 2.15600618010377e-09 1.38860404280618 0.655172413793103 19.3 19 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.54541553317347e-10 2.15600618010377e-09 1.38860404280618 0.655172413793103 19.3 19 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.54541553317347e-10 2.15600618010377e-09 1.38860404280618 0.655172413793103 19.3 19 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.57169224548558e-09 1.72039851178922e-08 1.38579310344828 0.653846153846154 19.3 19 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000494111789204474 0.00162383620332094 1.38579310344828 0.653846153846154 19.3 19 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000494111789204474 0.00162383620332094 1.38579310344828 0.653846153846154 19.3 19 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000494111789204474 0.00162383620332094 1.38579310344828 0.653846153846154 19.3 19 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.93447656995569e-14 8.18776501773912e-13 1.38447830923248 0.653225806451613 19.3 19 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.93447656995569e-14 8.18776501773912e-13 1.38447830923248 0.653225806451613 19.3 19 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.93447656995569e-14 8.18776501773912e-13 1.38447830923248 0.653225806451613 19.3 19 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 7.39537062791213e-09 6.33952554428853e-08 1.38352873563218 0.652777777777778 19.3 19 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.14589936526702e-11 5.45928633753045e-10 1.38321887477314 0.652631578947368 19.3 19 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.14589936526702e-11 5.45928633753045e-10 1.38321887477314 0.652631578947368 19.3 19 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.5733449231605e-55 1.1194349128287e-52 1.38207368559066 0.652091254752852 19.3 19 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.22860608855101e-17 5.63969827099383e-16 1.38166564818856 0.651898734177215 19.3 19 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.38319357354914e-11 2.52344160918003e-10 1.37764137931034 0.65 19.3 19 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.91520684812377e-05 8.30896141731747e-05 1.37764137931034 0.65 19.3 19 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00251229087422482 0.00687498060388831 1.37764137931034 0.65 19.3 19 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00251229087422482 0.00687498060388831 1.37764137931034 0.65 19.3 19 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00251229087422482 0.00687498060388831 1.37764137931034 0.65 19.3 19 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 7.00608536366957e-09 6.07746065598632e-08 1.37477726001864 0.648648648648649 19.3 19 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 7.00608536366957e-09 6.07746065598632e-08 1.37477726001864 0.648648648648649 19.3 19 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.30401481592767e-12 2.85478935856165e-11 1.37477726001864 0.648648648648649 19.3 19 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.51913174921489e-08 1.17485026039826e-07 1.37316367168528 0.647887323943662 19.3 19 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 9.31779630387103e-05 0.000369337719788537 1.37140770791075 0.647058823529412 19.3 19 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 9.31779630387103e-05 0.000369337719788537 1.37140770791075 0.647058823529412 19.3 19 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00573704862635248 0.0141242563932519 1.37140770791075 0.647058823529412 19.3 19 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 6.52091280130905e-10 8.51308157455301e-09 1.37140770791075 0.647058823529412 19.3 19 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 6.52091280130905e-10 8.51308157455301e-09 1.37140770791075 0.647058823529412 19.3 19 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.41041718107175e-09 1.5558322857869e-08 1.36988730025231 0.646341463414634 19.3 19 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 7.15434122501205e-08 4.42635981008354e-07 1.36948965517241 0.646153846153846 19.3 19 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.73518835435272e-06 1.78962054823028e-05 1.36881034482759 0.645833333333333 19.3 19 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.84964645663235e-23 1.88003350556274e-21 1.36861233957013 0.645739910313901 19.3 19 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.40770501624975e-14 1.4250304144673e-12 1.36846266630464 0.645669291338583 19.3 19 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.05162008783752e-09 3.0155940173561e-08 1.3682514185945 0.645569620253165 19.3 19 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 5.73288035816648e-12 1.10241739860418e-10 1.36674701901386 0.644859813084112 19.3 19 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 6.60495682383521e-09 5.83779724243323e-08 1.36648638838476 0.644736842105263 19.3 19 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 6.60495682383521e-09 5.83779724243323e-08 1.36648638838476 0.644736842105263 19.3 19 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.50818530042503e-13 6.15370290087037e-12 1.36625591336563 0.644628099173554 19.3 19 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.50818530042503e-13 6.15370290087037e-12 1.36625591336563 0.644628099173554 19.3 19 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.82436712508596e-15 1.59652893465054e-13 1.36250246305419 0.642857142857143 19.3 19 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000458966245384174 0.00153311964127155 1.36250246305419 0.642857142857143 19.3 19 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000458966245384174 0.00153311964127155 1.36250246305419 0.642857142857143 19.3 19 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0132640547629095 0.0290828196111252 1.36250246305419 0.642857142857143 19.3 19 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0132640547629095 0.0290828196111252 1.36250246305419 0.642857142857143 19.3 19 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0132640547629095 0.0290828196111252 1.36250246305419 0.642857142857143 19.3 19 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0132640547629095 0.0290828196111252 1.36250246305419 0.642857142857143 19.3 19 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0132640547629095 0.0290828196111252 1.36250246305419 0.642857142857143 19.3 19 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.36227531508567e-13 6.00271030958377e-12 1.3612716568545 0.642276422764228 19.3 19 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.86803392768402e-09 2.87409315429181e-08 1.36063346104725 0.641975308641975 19.3 19 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.34020342277612e-08 1.04213632273793e-07 1.35644689655172 0.64 19.3 19 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.34020342277612e-08 1.04213632273793e-07 1.35644689655172 0.64 19.3 19 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.34020342277612e-08 1.04213632273793e-07 1.35644689655172 0.64 19.3 19 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.34020342277612e-08 1.04213632273793e-07 1.35644689655172 0.64 19.3 19 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.34020342277612e-08 1.04213632273793e-07 1.35644689655172 0.64 19.3 19 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 3.48816377518957e-06 1.67691116624823e-05 1.35644689655172 0.64 19.3 19 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.48816377518957e-06 1.67691116624823e-05 1.35644689655172 0.64 19.3 19 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.24412014548454e-09 1.38311169298789e-08 1.35546110665597 0.63953488372093 19.3 19 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 7.8470733477771e-19 4.13569828662474e-17 1.35505709440362 0.639344262295082 19.3 19 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 7.8470733477771e-19 4.13569828662474e-17 1.35505709440362 0.639344262295082 19.3 19 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.89841465596441e-08 1.89194681442081e-07 1.35409195402299 0.638888888888889 19.3 19 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00230143838206305 0.00637149186318235 1.34873981191223 0.636363636363636 19.3 19 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00230143838206305 0.00637149186318235 1.34873981191223 0.636363636363636 19.3 19 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00230143838206305 0.00637149186318235 1.34873981191223 0.636363636363636 19.3 19 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0312119009192931 0.061261427597454 1.34873981191223 0.636363636363636 19.3 19 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0312119009192931 0.061261427597454 1.34873981191223 0.636363636363636 19.3 19 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0312119009192931 0.061261427597454 1.34873981191223 0.636363636363636 19.3 19 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0312119009192931 0.061261427597454 1.34873981191223 0.636363636363636 19.3 19 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0312119009192931 0.061261427597454 1.34873981191223 0.636363636363636 19.3 19 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0312119009192931 0.061261427597454 1.34873981191223 0.636363636363636 19.3 19 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.50346035643633e-09 2.54458863372064e-08 1.34647302231237 0.635294117647059 19.3 19 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.50346035643633e-09 2.54458863372064e-08 1.34647302231237 0.635294117647059 19.3 19 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.50346035643633e-09 2.54458863372064e-08 1.34647302231237 0.635294117647059 19.3 19 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 3.23778273288301e-06 1.57247946378585e-05 1.34503448275862 0.634615384615385 19.3 19 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 3.23778273288301e-06 1.57247946378585e-05 1.34503448275862 0.634615384615385 19.3 19 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 7.04420034753726e-06 3.17180215664175e-05 1.3408754398311 0.63265306122449 19.3 19 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.01822554242398e-21 7.62597340457536e-20 1.34009958249575 0.632286995515695 19.3 19 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 7.97084015844014e-05 0.000320409761171196 1.33859891107078 0.631578947368421 19.3 19 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00520272570244744 0.0129885590782153 1.33859891107078 0.631578947368421 19.3 19 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 5.00511811624316e-09 4.50777410089494e-08 1.33727093596059 0.630952380952381 19.3 19 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 5.00511811624316e-09 4.50777410089494e-08 1.33727093596059 0.630952380952381 19.3 19 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000936269340529749 0.00291534195092742 1.33446743295019 0.62962962962963 19.3 19 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.77007424630064e-14 1.75160284590651e-12 1.33222463054187 0.628571428571429 19.3 19 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.75558531048321e-11 6.36214035335429e-10 1.32947210031348 0.627272727272727 19.3 19 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 5.40828080731777e-07 2.88239085723341e-06 1.32465517241379 0.625 19.3 19 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000384779171370609 0.00129748995464544 1.32465517241379 0.625 19.3 19 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0118649170683752 0.0263397456915725 1.32465517241379 0.625 19.3 19 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0118649170683752 0.0263397456915725 1.32465517241379 0.625 19.3 19 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0118649170683752 0.0263397456915725 1.32465517241379 0.625 19.3 19 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0118649170683752 0.0263397456915725 1.32465517241379 0.625 19.3 19 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%REACT_208465.1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 EARLY STAGE PANCREATIC PRECURSOR CELLS%REACTOME%REACT_13403.1 EARLY STAGE PANCREATIC PRECURSOR CELLS 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0754673218959846 0.131123319973121 1.32465517241379 0.625 19.3 19 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 1.40713884724826e-05 6.19925256852718e-05 1.32465517241379 0.625 19.3 19 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00208551642057927 0.00583043195772948 1.32465517241379 0.625 19.3 19 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00208551642057927 0.00583043195772948 1.32465517241379 0.625 19.3 19 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00208551642057927 0.00583043195772948 1.32465517241379 0.625 19.3 19 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00208551642057927 0.00583043195772948 1.32465517241379 0.625 19.3 19 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 7.41049426780032e-11 1.09400626090235e-09 1.32222461246441 0.623853211009174 19.3 19 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.83266735944043e-09 1.94618332274906e-08 1.3218064516129 0.623655913978495 19.3 19 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.7778054063778e-12 5.56734801869804e-11 1.31839695900081 0.622047244094488 19.3 19 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.37495301169403e-11 2.52344160918003e-10 1.31797623877137 0.621848739495798 19.3 19 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000159348933128547 0.000606292865887493 1.31749487418453 0.621621621621622 19.3 19 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000159348933128547 0.000606292865887493 1.31749487418453 0.621621621621622 19.3 19 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.20097639451104e-08 2.62192517955667e-07 1.31459450021825 0.620253164556962 19.3 19 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.20097639451104e-08 2.62192517955667e-07 1.31459450021825 0.620253164556962 19.3 19 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.20097639451104e-08 2.62192517955667e-07 1.31459450021825 0.620253164556962 19.3 19 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.38408645194108e-19 3.06462200844486e-17 1.312039408867 0.619047619047619 19.3 19 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 6.63862240093293e-05 0.000267613588570186 1.312039408867 0.619047619047619 19.3 19 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 4.73746325401901e-13 1.10514921483099e-11 1.31131332175639 0.618705035971223 19.3 19 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 7.68460081258278e-09 6.54801614150018e-08 1.30977140643162 0.617977528089888 19.3 19 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 4.52740268632371e-07 2.42199023407468e-06 1.30907099391481 0.617647058823529 19.3 19 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.84035548306156e-08 2.45059455264421e-07 1.30830140485313 0.617283950617284 19.3 19 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.84035548306156e-08 2.45059455264421e-07 1.30830140485313 0.617283950617284 19.3 19 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 3.84035548306156e-08 2.45059455264421e-07 1.30830140485313 0.617283950617284 19.3 19 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.14217447324554e-12 4.48261121840117e-11 1.30672750842624 0.616541353383459 19.3 19 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0273761167157397 0.0546370464046249 1.30427586206897 0.615384615384615 19.3 19 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0273761167157397 0.0546370464046249 1.30427586206897 0.615384615384615 19.3 19 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0273761167157397 0.0546370464046249 1.30427586206897 0.615384615384615 19.3 19 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0273761167157397 0.0546370464046249 1.30427586206897 0.615384615384615 19.3 19 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0273761167157397 0.0546370464046249 1.30427586206897 0.615384615384615 19.3 19 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0273761167157397 0.0546370464046249 1.30427586206897 0.615384615384615 19.3 19 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 4.12233437916288e-07 2.26489645619644e-06 1.30194679802956 0.614285714285714 19.3 19 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 6.01231805970982e-05 0.000243054789743383 1.30057053291536 0.613636363636364 19.3 19 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 6.01231805970982e-05 0.000243054789743383 1.30057053291536 0.613636363636364 19.3 19 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 3.45653804235518e-19 2.04943901427976e-17 1.30057053291536 0.613636363636364 19.3 19 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.29441881805351e-72 1.84195797809014e-69 1.2970831643002 0.611990950226244 19.3 19 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.62748866356589e-12 3.50896419432465e-11 1.29606549243364 0.611510791366906 19.3 19 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0105057560596419 0.0237316105400726 1.2952183908046 0.611111111111111 19.3 19 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0105057560596419 0.0237316105400726 1.2952183908046 0.611111111111111 19.3 19 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0105057560596419 0.0237316105400726 1.2952183908046 0.611111111111111 19.3 19 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.88491033487224e-16 1.45479668592716e-14 1.29207007191591 0.609625668449198 19.3 19 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 5.42241928398495e-05 0.000221091766220934 1.29009895052474 0.608695652173913 19.3 19 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00415439440541789 0.0105003609927347 1.29009895052474 0.608695652173913 19.3 19 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00415439440541789 0.0105003609927347 1.29009895052474 0.608695652173913 19.3 19 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000683197778873305 0.00214611576012519 1.28451410658307 0.606060606060606 19.3 19 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000683197778873305 0.00214611576012519 1.28451410658307 0.606060606060606 19.3 19 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.06194265056302e-07 1.7154111778548e-06 1.28282395644283 0.605263157894737 19.3 19 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000281464414829569 0.0010038192037656 1.28282395644283 0.605263157894737 19.3 19 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000281464414829569 0.0010038192037656 1.28282395644283 0.605263157894737 19.3 19 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000116784986410849 0.000447938101516546 1.28152686447474 0.604651162790698 19.3 19 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000116784986410849 0.000447938101516546 1.28152686447474 0.604651162790698 19.3 19 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 9.37204574266793e-30 1.11136842431804e-27 1.28073612391665 0.60427807486631 19.3 19 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.71336182327762e-15 9.65278468631015e-14 1.27858020989505 0.603260869565217 19.3 19 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.88707084456183e-13 9.21883635301915e-12 1.27710344827586 0.602564102564103 19.3 19 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 3.25517461953982e-06 1.57554880394734e-05 1.27166896551724 0.6 19.3 19 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.000608856105910486 0.00192106926543375 1.27166896551724 0.6 19.3 19 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000608856105910486 0.00192106926543375 1.27166896551724 0.6 19.3 19 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.05656927657288e-07 6.29078694796322e-07 1.27166896551724 0.6 19.3 19 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.05656927657288e-07 6.29078694796322e-07 1.27166896551724 0.6 19.3 19 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.05656927657288e-07 6.29078694796322e-07 1.27166896551724 0.6 19.3 19 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.05656927657288e-07 6.29078694796322e-07 1.27166896551724 0.6 19.3 19 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.05656927657288e-07 6.29078694796322e-07 1.27166896551724 0.6 19.3 19 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00367631881302756 0.00937045572011481 1.27166896551724 0.6 19.3 19 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00367631881302756 0.00937045572011481 1.27166896551724 0.6 19.3 19 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00367631881302756 0.00937045572011481 1.27166896551724 0.6 19.3 19 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00367631881302756 0.00937045572011481 1.27166896551724 0.6 19.3 19 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00367631881302756 0.00937045572011481 1.27166896551724 0.6 19.3 19 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00367631881302756 0.00937045572011481 1.27166896551724 0.6 19.3 19 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00923837794478136 0.0213412529471167 1.27166896551724 0.6 19.3 19 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00923837794478136 0.0213412529471167 1.27166896551724 0.6 19.3 19 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0238164035360328 0.048003884180984 1.27166896551724 0.6 19.3 19 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0238164035360328 0.048003884180984 1.27166896551724 0.6 19.3 19 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0238164035360328 0.048003884180984 1.27166896551724 0.6 19.3 19 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0238164035360328 0.048003884180984 1.27166896551724 0.6 19.3 19 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0238164035360328 0.048003884180984 1.27166896551724 0.6 19.3 19 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0238164035360328 0.048003884180984 1.27166896551724 0.6 19.3 19 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0642028149028587 0.114058184278112 1.27166896551724 0.6 19.3 19 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0642028149028587 0.114058184278112 1.27166896551724 0.6 19.3 19 3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.0642028149028587 0.114058184278112 1.27166896551724 0.6 19.3 19 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0642028149028587 0.114058184278112 1.27166896551724 0.6 19.3 19 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0642028149028587 0.114058184278112 1.27166896551724 0.6 19.3 19 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0642028149028587 0.114058184278112 1.27166896551724 0.6 19.3 19 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0642028149028587 0.114058184278112 1.27166896551724 0.6 19.3 19 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0642028149028587 0.114058184278112 1.27166896551724 0.6 19.3 19 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 4.04611472335684e-08 2.5589427783719e-07 1.26706146926537 0.597826086956522 19.3 19 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.00861600450393e-12 2.24259464751421e-11 1.2584224137931 0.59375 19.3 19 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0032388874559978 0.00837988518160885 1.255969348659 0.592592592592593 19.3 19 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0032388874559978 0.00837988518160885 1.255969348659 0.592592592592593 19.3 19 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0032388874559978 0.00837988518160885 1.255969348659 0.592592592592593 19.3 19 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 8.28887208246008e-05 0.00033225535136171 1.25436734693878 0.591836734693878 19.3 19 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.59768929118358e-07 9.27964025042547e-07 1.2524012539185 0.590909090909091 19.3 19 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000198629817030713 0.000749735357121233 1.2524012539185 0.590909090909091 19.3 19 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00808480379393707 0.0188601242602827 1.2524012539185 0.590909090909091 19.3 19 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.75960607263396e-09 4.34161502651162e-08 1.2524012539185 0.590909090909091 19.3 19 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000478608338959466 0.00158385968916121 1.24993103448276 0.58974358974359 19.3 19 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00116131511385954 0.00352345669902971 1.24673427991886 0.588235294117647 19.3 19 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00116131511385954 0.00352345669902971 1.24673427991886 0.588235294117647 19.3 19 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0206190148426935 0.042156405346484 1.24673427991886 0.588235294117647 19.3 19 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0206190148426935 0.042156405346484 1.24673427991886 0.588235294117647 19.3 19 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0206190148426935 0.042156405346484 1.24673427991886 0.588235294117647 19.3 19 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0206190148426935 0.042156405346484 1.24673427991886 0.588235294117647 19.3 19 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0206190148426935 0.042156405346484 1.24673427991886 0.588235294117647 19.3 19 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.34328158727497e-07 1.85116330688416e-06 1.24673427991886 0.588235294117647 19.3 19 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.06859427671931e-08 1.5095434132162e-07 1.24313793103448 0.586538461538462 19.3 19 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00284375184259978 0.00743536740082349 1.24243519619501 0.586206896551724 19.3 19 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 4.08008959717792e-23 3.62872968549012e-21 1.24176264015232 0.585889570552147 19.3 19 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 4.34909294690336e-06 2.04249480641699e-05 1.24139113300493 0.585714285714286 19.3 19 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.49371238055638e-12 5.06936102504532e-11 1.24065264928511 0.585365853658537 19.3 19 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00102175899198964 0.00314030895378241 1.23634482758621 0.583333333333333 19.3 19 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00102175899198964 0.00314030895378241 1.23634482758621 0.583333333333333 19.3 19 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00102175899198964 0.00314030895378241 1.23634482758621 0.583333333333333 19.3 19 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0544735450378384 0.0984953679654944 1.23634482758621 0.583333333333333 19.3 19 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0544735450378384 0.0984953679654944 1.23634482758621 0.583333333333333 19.3 19 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0544735450378384 0.0984953679654944 1.23634482758621 0.583333333333333 19.3 19 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00249012211547155 0.00685385642227469 1.23064738598443 0.580645161290323 19.3 19 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00249012211547155 0.00685385642227469 1.23064738598443 0.580645161290323 19.3 19 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 8.04663761666167e-06 3.57823916515923e-05 1.22866566716642 0.579710144927536 19.3 19 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0177974228007843 0.0370259249203452 1.22704900181488 0.578947368421053 19.3 19 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0177974228007843 0.0370259249203452 1.22704900181488 0.578947368421053 19.3 19 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0177974228007843 0.0370259249203452 1.22704900181488 0.578947368421053 19.3 19 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.14162150797678e-06 5.82267887401776e-06 1.22570502700457 0.578313253012048 19.3 19 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.11036463786872e-06 3.17180215664175e-05 1.22390675084993 0.577464788732394 19.3 19 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00613351762551711 0.0150223676094851 1.22275862068966 0.576923076923077 19.3 19 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00613351762551711 0.0150223676094851 1.22275862068966 0.576923076923077 19.3 19 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.67335294322714e-05 7.30423692703137e-05 1.22028840125392 0.575757575757576 19.3 19 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00217581703090154 0.00605907560660057 1.22028840125392 0.575757575757576 19.3 19 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00217581703090154 0.00605907560660057 1.22028840125392 0.575757575757576 19.3 19 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 6.47627198943905e-11 9.7007737273387e-10 1.21697352614016 0.574193548387097 19.3 19 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000106143240593312 0.000417242628078129 1.21672030651341 0.574074074074074 19.3 19 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.63424716894174e-18 1.29259783496693e-16 1.21657861322047 0.574007220216607 19.3 19 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.04695016330107e-09 6.07746065598632e-08 1.21607687959299 0.573770491803279 19.3 19 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.91882696005519e-10 5.26084034354579e-09 1.21534796238245 0.573426573426573 19.3 19 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 6.22827689951234e-09 5.57411196729941e-08 1.21355506117909 0.57258064516129 19.3 19 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.000252121232063864 0.000912218263327765 1.21111330049261 0.571428571428571 19.3 19 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00532551129268552 0.0132486058907194 1.21111330049261 0.571428571428571 19.3 19 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0461921993195132 0.0840556261274518 1.21111330049261 0.571428571428571 19.3 19 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0461921993195132 0.0840556261274518 1.21111330049261 0.571428571428571 19.3 19 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0461921993195132 0.0840556261274518 1.21111330049261 0.571428571428571 19.3 19 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0461921993195132 0.0840556261274518 1.21111330049261 0.571428571428571 19.3 19 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0461921993195132 0.0840556261274518 1.21111330049261 0.571428571428571 19.3 19 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0461921993195132 0.0840556261274518 1.21111330049261 0.571428571428571 19.3 19 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0153330677431412 0.0330590233310454 1.21111330049261 0.571428571428571 19.3 19 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0153330677431412 0.0330590233310454 1.21111330049261 0.571428571428571 19.3 19 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0153330677431412 0.0330590233310454 1.21111330049261 0.571428571428571 19.3 19 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 4.28935485959199e-06 2.02110992225146e-05 1.20728066346574 0.569620253164557 19.3 19 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 8.21566605907181e-33 1.4613616002574e-30 1.20657729562185 0.569288389513109 19.3 19 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00461740429913626 0.0115883003838993 1.20102068965517 0.566666666666667 19.3 19 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00461740429913626 0.0115883003838993 1.20102068965517 0.566666666666667 19.3 19 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0005245357191101 0.0017020698619752 1.19794902548726 0.565217391304348 19.3 19 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.013194335999012 0.0290828196111252 1.19794902548726 0.565217391304348 19.3 19 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.04244718329873e-45 5.81280468366818e-43 1.19405536668286 0.563380281690141 19.3 19 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.000457403905305425 0.00153311964127155 1.19218965517241 0.5625 19.3 19 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0391826004230212 0.0721612929553747 1.19218965517241 0.5625 19.3 19 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0391826004230212 0.0721612929553747 1.19218965517241 0.5625 19.3 19 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0391826004230212 0.0721612929553747 1.19218965517241 0.5625 19.3 19 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0391826004230212 0.0721612929553747 1.19218965517241 0.5625 19.3 19 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 3.59184856032651e-08 2.3338815074633e-07 1.19109489883158 0.56198347107438 19.3 19 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00125040798199909 0.00368232164515236 1.18895878889823 0.560975609756098 19.3 19 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00125040798199909 0.00368232164515236 1.18895878889823 0.560975609756098 19.3 19 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00125040798199909 0.00368232164515236 1.18895878889823 0.560975609756098 19.3 19 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00125040798199909 0.00368232164515236 1.18895878889823 0.560975609756098 19.3 19 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0113456478384011 0.0253849950849761 1.18689103448276 0.56 19.3 19 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0113456478384011 0.0253849950849761 1.18689103448276 0.56 19.3 19 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00034700752748349 0.00117998478870615 1.182 0.557692307692308 19.3 19 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000112235709031754 0.000432822260033026 1.18133182589033 0.557377049180328 19.3 19 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0097518053374162 0.0224496438811916 1.17747126436782 0.555555555555556 19.3 19 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.000942800154256009 0.0029292677281797 1.17747126436782 0.555555555555556 19.3 19 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.033260588321508 0.063615345674067 1.17747126436782 0.555555555555556 19.3 19 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.033260588321508 0.063615345674067 1.17747126436782 0.555555555555556 19.3 19 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.033260588321508 0.063615345674067 1.17747126436782 0.555555555555556 19.3 19 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.125961077469849 0.202111278524798 1.17747126436782 0.555555555555556 19.3 19 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.87023241269485e-08 1.89194681442081e-07 1.17211912225705 0.553030303030303 19.3 19 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00258739662853738 0.00701307695696894 1.17127404718693 0.552631578947368 19.3 19 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00837998446202184 0.0194530471279887 1.16935077288942 0.551724137931034 19.3 19 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.75498732819272e-14 8.16738951670467e-13 1.16906075533662 0.551587301587302 19.3 19 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.75498732819272e-14 8.16738951670467e-13 1.16906075533662 0.551587301587302 19.3 19 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.75498732819272e-14 8.16738951670467e-13 1.16906075533662 0.551587301587302 19.3 19 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.34227226522348e-06 6.77323912557806e-06 1.16162068965517 0.548076923076923 19.3 19 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00193153445559269 0.00551922395644256 1.16065024630542 0.547619047619048 19.3 19 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00193153445559269 0.00551922395644256 1.16065024630542 0.547619047619048 19.3 19 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.103791911683137 0.170156555674083 1.15606269592477 0.545454545454545 19.3 19 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.103791911683137 0.170156555674083 1.15606269592477 0.545454545454545 19.3 19 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.103791911683137 0.170156555674083 1.15606269592477 0.545454545454545 19.3 19 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.103791911683137 0.170156555674083 1.15606269592477 0.545454545454545 19.3 19 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.103791911683137 0.170156555674083 1.15606269592477 0.545454545454545 19.3 19 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.103791911683137 0.170156555674083 1.15606269592477 0.545454545454545 19.3 19 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.103791911683137 0.170156555674083 1.15606269592477 0.545454545454545 19.3 19 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000461691759652677 0.00153861211706267 1.15606269592476 0.545454545454545 19.3 19 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0061871596666139 0.0151017636459547 1.15606269592476 0.545454545454545 19.3 19 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0061871596666139 0.0151017636459547 1.15606269592476 0.545454545454545 19.3 19 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.25758996123018e-07 1.27482163286927e-06 1.15449621530698 0.544715447154472 19.3 19 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00144073400562017 0.00415013054655366 1.15187406296852 0.543478260869565 19.3 19 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00144073400562017 0.00415013054655366 1.15187406296852 0.543478260869565 19.3 19 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00531682702327346 0.0132486058907194 1.15055763546798 0.542857142857143 19.3 19 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000346342500795585 0.00117998478870615 1.14953126826417 0.542372881355932 19.3 19 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 9.73856773262044e-09 7.9643574043212e-08 1.1486042269188 0.541935483870968 19.3 19 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.020454850671072 0.0421233755498343 1.14803448275862 0.541666666666667 19.3 19 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00456949804724734 0.0115086649933327 1.1456477166822 0.540540540540541 19.3 19 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00456949804724734 0.0115086649933327 1.1456477166822 0.540540540540541 19.3 19 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00392783386942294 0.00996311514472165 1.14124137931034 0.538461538461538 19.3 19 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00392783386942294 0.00996311514472165 1.14124137931034 0.538461538461538 19.3 19 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0174264664200992 0.036413893855802 1.14124137931034 0.538461538461538 19.3 19 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0174264664200992 0.036413893855802 1.14124137931034 0.538461538461538 19.3 19 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0174264664200992 0.036413893855802 1.14124137931034 0.538461538461538 19.3 19 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0860872114136202 0.148667599322308 1.14124137931034 0.538461538461538 19.3 19 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0860872114136202 0.148667599322308 1.14124137931034 0.538461538461538 19.3 19 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0860872114136202 0.148667599322308 1.14124137931034 0.538461538461538 19.3 19 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.9752338068956e-06 9.82782415109242e-06 1.13541871921182 0.535714285714286 19.3 19 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0148590676967208 0.0322255387123686 1.13541871921182 0.535714285714286 19.3 19 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 2.13848094710481e-08 1.5525808100664e-07 1.13397232593894 0.535031847133758 19.3 19 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.28495938306459e-07 1.82597546957067e-06 1.13252961305607 0.534351145038168 19.3 19 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.28495938306459e-07 1.82597546957067e-06 1.13252961305607 0.534351145038168 19.3 19 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 5.11919161178521e-06 2.35747885552439e-05 1.1303724137931 0.533333333333333 19.3 19 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0126800760767482 0.0280618168852452 1.1303724137931 0.533333333333333 19.3 19 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0126800760767482 0.0280618168852452 1.1303724137931 0.533333333333333 19.3 19 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.17706270201053e-09 1.31886631886691e-08 1.12595689655172 0.53125 19.3 19 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00184856611981507 0.00530344675100169 1.12460520760028 0.530612244897959 19.3 19 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0092542549000055 0.0213432815603044 1.12206085192698 0.529411764705882 19.3 19 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.06006663420089 0.107786658849769 1.12206085192698 0.529411764705882 19.3 19 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.06006663420089 0.107786658849769 1.12206085192698 0.529411764705882 19.3 19 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00496676154878413 0.0124212683372932 1.11018719211823 0.523809523809524 19.3 19 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 6.76842420506556e-09 5.94535039741253e-08 1.10387931034483 0.520833333333333 19.3 19 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0303231537397989 0.060181098705347 1.10211310344828 0.52 19.3 19 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0303231537397989 0.060181098705347 1.10211310344828 0.52 19.3 19 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00230737086232691 0.00637551211085669 1.10048275862069 0.519230769230769 19.3 19 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 9.3173195426224e-07 4.82128934878243e-06 1.09730300807043 0.517730496453901 19.3 19 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0218009425910412 0.0444451881189851 1.09626634958383 0.517241379310345 19.3 19 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00108205192137723 0.00331089312608514 1.09390878754171 0.516129032258065 19.3 19 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0185249223825971 0.0383711274387711 1.09390878754171 0.516129032258065 19.3 19 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00976551620692735 0.0224496438811916 1.08689655172414 0.512820512820513 19.3 19 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00834002175577456 0.0193919133308288 1.08557106812447 0.51219512195122 19.3 19 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00834002175577456 0.0193919133308288 1.08557106812447 0.51219512195122 19.3 19 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.51368249573755e-07 8.90070327039064e-07 1.08436888532478 0.511627906976744 19.3 19 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 9.83106665784498e-09 7.99406163092194e-08 1.07990935960591 0.509523809523809 19.3 19 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00281427719137904 0.00743536740082349 1.07899184952978 0.509090909090909 19.3 19 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000340132801805091 0.00116910380910301 1.072491898629 0.506024096385542 19.3 19 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 8.07836199549843e-53 3.83183637319809e-50 1.06724961599252 0.503550677856682 19.3 19 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.007303242775524 0.0171211111525052 1.05972413793103 0.5 19.3 19 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.007303242775524 0.0171211111525052 1.05972413793103 0.5 19.3 19 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.0189327003432666 0.0391019340906653 1.05972413793103 0.5 19.3 19 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.022266670540217 0.0452649602553268 1.05972413793103 0.5 19.3 19 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.022266670540217 0.0452649602553268 1.05972413793103 0.5 19.3 19 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0365239043984869 0.0691137180306475 1.05972413793103 0.5 19.3 19 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0365239043984869 0.0691137180306475 1.05972413793103 0.5 19.3 19 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0726252890642805 0.128539535246855 1.05972413793103 0.5 19.3 19 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0726252890642805 0.128539535246855 1.05972413793103 0.5 19.3 19 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0868726800802718 0.149842210611184 1.05972413793103 0.5 19.3 19 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.104346474292532 0.170868852610211 1.05972413793103 0.5 19.3 19 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.125982223507727 0.202111278524798 1.05972413793103 0.5 19.3 19 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.125982223507727 0.202111278524798 1.05972413793103 0.5 19.3 19 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.153110278328437 0.241181377922621 1.05972413793103 0.5 19.3 19 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.153110278328437 0.241181377922621 1.05972413793103 0.5 19.3 19 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.153110278328437 0.241181377922621 1.05972413793103 0.5 19.3 19 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.18771934003684 0.289409123372073 1.05972413793103 0.5 19.3 19 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.18771934003684 0.289409123372073 1.05972413793103 0.5 19.3 19 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.18771934003684 0.289409123372073 1.05972413793103 0.5 19.3 19 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.9933937098009e-31 2.57872659004244e-29 1.05017707362535 0.495495495495495 19.3 19 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.09977631059768e-14 1.10075126226047e-12 1.04071563321478 0.491031390134529 19.3 19 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00628472119486805 0.0152613622189373 1.04045642633229 0.490909090909091 19.3 19 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00733893192018068 0.0171764804645018 1.03972934287573 0.490566037735849 19.3 19 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.75924163902877e-19 1.08843515319041e-17 1.03829892207862 0.489891135303266 19.3 19 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0188693792494142 0.0390278003952274 1.03387720773759 0.48780487804878 19.3 19 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000265837650117005 0.000952863919688913 1.03001224621334 0.485981308411215 19.3 19 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0306187463236845 0.0606831142320377 1.02944630541872 0.485714285714286 19.3 19 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.33391233806342e-16 5.423306448755e-15 1.02817368198563 0.485113835376532 19.3 19 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0360663738750243 0.0684299333655461 1.02761128526646 0.484848484848485 19.3 19 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0360663738750243 0.0684299333655461 1.02761128526646 0.484848484848485 19.3 19 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0425438904079002 0.0780154072814973 1.02553948832036 0.483870967741935 19.3 19 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.69031955576072e-14 8.16738951670467e-13 1.02526156433978 0.483739837398374 19.3 19 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00726909443214367 0.0170973907056867 1.02318192627824 0.482758620689655 19.3 19 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00726909443214367 0.0170973907056867 1.02318192627824 0.482758620689655 19.3 19 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00726909443214367 0.0170973907056867 1.02318192627824 0.482758620689655 19.3 19 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000305784861985534 0.00105614528787722 1.02118871473354 0.481818181818182 19.3 19 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00183087092828192 0.005263291577667 1.02047509578544 0.481481481481481 19.3 19 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0594961707134006 0.107032934165827 1.02047509578544 0.481481481481481 19.3 19 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0594961707134006 0.107032934165827 1.02047509578544 0.481481481481481 19.3 19 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0705684638245359 0.125210628456751 1.01733517241379 0.48 19.3 19 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0839018713799294 0.145423097410036 1.01364917541229 0.478260869565217 19.3 19 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0839018713799294 0.145423097410036 1.01364917541229 0.478260869565217 19.3 19 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 6.35054375859187e-06 2.91510444144394e-05 1.00055172413793 0.472081218274112 19.3 19 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 4.2481354250104e-05 0.000179379724326107 1.00048490040694 0.472049689440994 19.3 19 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00594952762293003 0.014622068752037 0.999168472906404 0.471428571428571 19.3 19 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.143706332151769 0.228496688611534 0.997387423935091 0.470588235294118 19.3 19 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.143706332151769 0.228496688611534 0.997387423935091 0.470588235294118 19.3 19 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00127315688644762 0.00368232164515236 0.996140689655172 0.47 19.3 19 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 5.50738878900924e-05 0.000223914692764576 0.994309067688378 0.469135802469136 19.3 19 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00368101528288418 0.00937045572011481 0.994309067688378 0.469135802469136 19.3 19 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0569463669871382 0.102705551613052 0.993491379310345 0.46875 19.3 19 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000500982883835037 0.00164262360298907 0.990234030525721 0.467213114754098 19.3 19 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.173422698888934 0.268531556603866 0.989075862068965 0.466666666666667 19.3 19 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0940101404802823 0.160019652994548 0.978206896551724 0.461538461538462 19.3 19 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0940101404802823 0.160019652994548 0.978206896551724 0.461538461538462 19.3 19 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.210558621398279 0.317063405555292 0.978206896551724 0.461538461538462 19.3 19 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.210558621398279 0.317063405555292 0.978206896551724 0.461538461538462 19.3 19 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.210558621398279 0.317063405555292 0.978206896551724 0.461538461538462 19.3 19 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00741762607568128 0.0173321541965426 0.976061705989111 0.460526315789474 19.3 19 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0317474504197477 0.0621411581118307 0.971413793103448 0.458333333333333 19.3 19 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0317474504197477 0.0621411581118307 0.971413793103448 0.458333333333333 19.3 19 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.111529772945832 0.182212246730102 0.971413793103448 0.458333333333333 19.3 19 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 3.95342900142608e-06 1.88151487258506e-05 0.970349813045285 0.457831325301205 19.3 19 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.132626237144806 0.212052961187706 0.963385579937304 0.454545454545455 19.3 19 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.257658863664925 0.368861733395562 0.963385579937304 0.454545454545455 19.3 19 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0743463612472334 0.131096495730871 0.963385579937304 0.454545454545455 19.3 19 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0743463612472334 0.131096495730871 0.963385579937304 0.454545454545455 19.3 19 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0743463612472334 0.131096495730871 0.963385579937304 0.454545454545455 19.3 19 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.018021100778249 0.0374365349013845 0.960375 0.453125 19.3 19 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0299546953326423 0.0596161279137762 0.959750162654522 0.452830188679245 19.3 19 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000428640453900052 0.00144197486028315 0.957170189098999 0.451612903225806 19.3 19 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.158143667388199 0.246752674005929 0.953751724137931 0.45 19.3 19 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.158143667388199 0.246752674005929 0.953751724137931 0.45 19.3 19 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000582048975908537 0.00184466746707761 0.94642029928432 0.446540880503145 19.3 19 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000582048975908537 0.00184466746707761 0.94642029928432 0.446540880503145 19.3 19 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 3.77929034492467e-05 0.000160535228681427 0.946019831286074 0.446351931330472 19.3 19 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00918760827741113 0.0212931051771271 0.941977011494253 0.444444444444444 19.3 19 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.121621316293788 0.198017314743776 0.941977011494253 0.444444444444444 19.3 19 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0263530489917008 0.0530415681968744 0.941977011494253 0.444444444444444 19.3 19 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.143713658683994 0.228496688611534 0.93255724137931 0.44 19.3 19 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0408764204878613 0.0750543823925505 0.929582577132486 0.43859649122807 19.3 19 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.111243448790208 0.18195336509019 0.927258620689655 0.4375 19.3 19 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.227148651352802 0.340244769342144 0.927258620689655 0.4375 19.3 19 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.227148651352802 0.340244769342144 0.927258620689655 0.4375 19.3 19 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.227148651352802 0.340244769342144 0.927258620689655 0.4375 19.3 19 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.227148651352802 0.340244769342144 0.927258620689655 0.4375 19.3 19 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0473158896693485 0.0858807538258711 0.924850156739812 0.436363636363636 19.3 19 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.170106518502403 0.263683633800565 0.921499250374813 0.434782608695652 19.3 19 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.13052781232586 0.209167879436598 0.918427586206896 0.433333333333333 19.3 19 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.67289703849576e-07 9.6769613243068e-07 0.912005015673981 0.43030303030303 19.3 19 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00464985274000733 0.0116491909313916 0.908334975369458 0.428571428571429 19.3 19 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.118608561370077 0.193333313665086 0.908334975369458 0.428571428571429 19.3 19 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.273990919816193 0.387563696718134 0.908334975369458 0.428571428571429 19.3 19 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.138430776453452 0.221085291687163 0.89915987460815 0.424242424242424 19.3 19 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.000339647018634286 0.00116910380910301 0.897648681541582 0.423529411764706 19.3 19 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0036705437539683 0.00937045572011481 0.897189760947747 0.423312883435583 19.3 19 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0309342484672003 0.0612231370915521 0.891131661442006 0.420454545454545 19.3 19 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0285031076102766 0.0568066136266436 0.888800889877642 0.419354838709677 19.3 19 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.161611777810217 0.251062838235741 0.888800889877642 0.419354838709677 19.3 19 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.161611777810217 0.251062838235741 0.888800889877642 0.419354838709677 19.3 19 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00979978376818201 0.0224920843582629 0.888298174442191 0.419117647058824 19.3 19 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.113582177273741 0.185352566812538 0.88721090617482 0.418604651162791 19.3 19 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.332336424619559 0.452117334831389 0.883103448275862 0.416666666666667 19.3 19 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.332336424619559 0.452117334831389 0.883103448275862 0.416666666666667 19.3 19 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.332336424619559 0.452117334831389 0.883103448275862 0.416666666666667 19.3 19 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0116274890336859 0.0259747517973862 0.881814246161591 0.416058394160584 19.3 19 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0107426172056296 0.0241115840435503 0.880615832928606 0.415492957746479 19.3 19 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.13133142006631 0.210218909734937 0.878795626576955 0.414634146341463 19.3 19 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0214532887482158 0.0437991820498007 0.867805593266359 0.409448818897638 19.3 19 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.24956499092589 0.363491281563502 0.867047021943574 0.409090909090909 19.3 19 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0181904025036329 0.0377331527152619 0.866343820790335 0.408759124087591 19.3 19 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00198998430995868 0.0056363104634358 0.864402434077079 0.407843137254902 19.3 19 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.196074318718645 0.296507710453381 0.861025862068966 0.40625 19.3 19 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0552601502345985 0.0997908550556266 0.852149306789904 0.402061855670103 19.3 19 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.202450857207228 0.305825445653806 0.847779310344828 0.4 19.3 19 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.181076903640266 0.280078732478368 0.847779310344828 0.4 19.3 19 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.22751390512958 0.340433529967815 0.847779310344828 0.4 19.3 19 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.257435979282022 0.368861733395562 0.847779310344828 0.4 19.3 19 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.294117652836789 0.411467370722872 0.847779310344828 0.4 19.3 19 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.341036400434367 0.463509835547377 0.847779310344828 0.4 19.3 19 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0198180180040204 0.0408710719126393 0.836322833178006 0.394594594594595 19.3 19 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.13978495551684 0.22299774854312 0.833881288863765 0.39344262295082 19.3 19 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.263845394929626 0.377338690437044 0.83264039408867 0.392857142857143 19.3 19 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.269136301331282 0.384519032926119 0.820431590656285 0.387096774193548 19.3 19 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.305731650479089 0.426107873292599 0.815172413793103 0.384615384615385 19.3 19 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.305731650479089 0.426107873292599 0.815172413793103 0.384615384615385 19.3 19 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.408447551632859 0.531557726463238 0.815172413793103 0.384615384615385 19.3 19 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.408447551632859 0.531557726463238 0.815172413793103 0.384615384615385 19.3 19 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.224497520931674 0.337695530957475 0.805390344827586 0.38 19.3 19 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.161107251269031 0.250826716144235 0.797909939148073 0.376470588235294 19.3 19 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.161107251269031 0.250826716144235 0.797909939148073 0.376470588235294 19.3 19 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.312973490898865 0.435774244177186 0.794793103448276 0.375 19.3 19 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.409369049883305 0.531557726463238 0.794793103448276 0.375 19.3 19 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.409369049883305 0.531557726463238 0.794793103448276 0.375 19.3 19 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.409369049883305 0.531557726463238 0.794793103448276 0.375 19.3 19 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.166670384479609 0.25863899358177 0.789156272927366 0.372340425531915 19.3 19 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.409407778077097 0.531557726463238 0.780849364791289 0.368421052631579 19.3 19 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.409407778077097 0.531557726463238 0.780849364791289 0.368421052631579 19.3 19 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.408921694635085 0.531557726463238 0.770708463949843 0.363636363636364 19.3 19 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.292734903904027 0.411467370722872 0.764391181458451 0.360655737704918 19.3 19 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.407073664133777 0.531557726463238 0.756945812807882 0.357142857142857 19.3 19 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.483145680419896 0.623880492956 0.756945812807882 0.357142857142857 19.3 19 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.483145680419896 0.623880492956 0.756945812807882 0.357142857142857 19.3 19 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.272916814246648 0.387563696718134 0.749299895506792 0.353535353535354 19.3 19 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.476902199932276 0.616938027730572 0.748040567951318 0.352941176470588 19.3 19 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.000768213519709899 0.00239729789155085 0.747493221194281 0.352682926829268 19.3 19 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.471487076283417 0.610487815788264 0.741806896551724 0.35 19.3 19 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.471487076283417 0.610487815788264 0.741806896551724 0.35 19.3 19 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.471487076283417 0.610487815788264 0.741806896551724 0.35 19.3 19 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.253326620925418 0.368592823698231 0.736637510513036 0.347560975609756 19.3 19 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.321195218342303 0.438217445542758 0.733655172413793 0.346153846153846 19.3 19 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.404198688985548 0.531377272047664 0.71391941923775 0.336842105263158 19.3 19 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.515494763632896 0.648011527075628 0.70648275862069 0.333333333333333 19.3 19 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.492022807471843 0.631333142499939 0.70648275862069 0.333333333333333 19.3 19 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.523071312999385 0.656796666423031 0.70648275862069 0.333333333333333 19.3 19 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.541906201279292 0.660546344890279 0.70648275862069 0.333333333333333 19.3 19 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.554200320412661 0.674040218758305 0.70648275862069 0.333333333333333 19.3 19 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.554200320412661 0.674040218758305 0.70648275862069 0.333333333333333 19.3 19 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.523406479074994 0.656796666423031 0.691124437781109 0.326086956521739 19.3 19 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.542177182594411 0.660546344890279 0.68738863000932 0.324324324324324 19.3 19 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.563012757981665 0.684173488136558 0.676419662509171 0.319148936170213 19.3 19 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.57337673093144 0.693805347036938 0.670711479703186 0.316455696202532 19.3 19 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.603059319680305 0.723569487272406 0.66929945553539 0.315789473684211 19.3 19 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.586899645192085 0.709562705238987 0.667233716475096 0.314814814814815 19.3 19 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.620032716107822 0.737125290053068 0.662327586206897 0.3125 19.3 19 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.609348218240669 0.730499169803262 0.659383908045977 0.311111111111111 19.3 19 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.638099980095814 0.754166338601614 0.64881069669247 0.306122448979592 19.3 19 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.648955562423152 0.764456759377603 0.642257053291536 0.303030303030303 19.3 19 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.659447423993257 0.776173436180649 0.635834482758621 0.3 19.3 19 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.661538138183986 0.777990719533729 0.635834482758621 0.3 19.3 19 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.679670431180968 0.790854369957889 0.623367139959432 0.294117647058824 19.3 19 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.71052890829595 0.816271541178444 0.605556650246305 0.285714285714286 19.3 19 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.821487879092398 0.913263478084752 0.590226102138804 0.278481012658228 19.3 19 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.732656673450842 0.838753375961825 0.588735632183908 0.277777777777778 19.3 19 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.793984340652485 0.884760937156214 0.565186206896552 0.266666666666667 19.3 19 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.848391822160184 0.941701687155961 0.559854261548471 0.264150943396226 19.3 19 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.778941442654606 0.880335158500243 0.557749546279492 0.263157894736842 19.3 19 3 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.796128625306854 0.886456207990339 0.552899550224888 0.260869565217391 19.3 19 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.885058574312337 0.970291487863217 0.552899550224888 0.260869565217391 19.3 19 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.912077190244568 0.993026657779664 0.537324915007285 0.253521126760563 19.3 19 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.988372990241512 1 0.524164627363737 0.247311827956989 19.3 19 3 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.860731481944601 0.946538561674782 0.508667586206897 0.24 19.3 19 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.860731481944601 0.946538561674782 0.508667586206897 0.24 19.3 19 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.852598992806025 0.941949569501442 0.504630541871921 0.238095238095238 19.3 19 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999887685459688 1 0.50254959118379 0.237113402061856 19.3 19 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.997831819488641 1 0.498119180041316 0.235023041474654 19.3 19 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999847662250184 1 0.476875862068966 0.225 19.3 19 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.952985067789969 1 0.446199637023594 0.210526315789474 19.3 19 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.998821116104287 1 0.412114942528736 0.194444444444444 19.3 19 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.961738586639696 1 0.410215795328142 0.193548387096774 19.3 19 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.986920888672768 1 0.397396551724138 0.1875 19.3 19 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.986920888672768 1 0.397396551724138 0.1875 19.3 19 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.386163119951359 0.182199832073887 19.3 19 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.9709712180257 1 0.378472906403941 0.178571428571429 19.3 19 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.981248664792026 1 0.374020283975659 0.176470588235294 19.3 19 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999995104780814 1 0.373311912225705 0.176136363636364 19.3 19 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.985337045296658 1 0.363333990147783 0.171428571428571 19.3 19 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.982566434211654 1 0.353241379310345 0.166666666666667 19.3 19 3 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.986571789513953 1 0.341846496106785 0.161290322580645 19.3 19 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.986571789513953 1 0.341846496106785 0.161290322580645 19.3 19 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.327690465797843 0.154611211573237 19.3 19 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999963004142389 1 0.306142528735632 0.144444444444444 19.3 19 3 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999861666613658 1 0.22547322083639 0.106382978723404 19.3 19 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 1.56757387399592e-05 9.10472499059669e-05 2.97014830777031 0.9 19.2 19 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 6.09113362840205e-05 0.000319840706760742 2.93347981014352 0.888888888888889 19.2 19 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.000233926114338868 0.00105234218998138 2.88764418811003 0.875 19.2 19 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000885261019951537 0.00334871047316344 2.82871267406697 0.857142857142857 19.2 19 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000885261019951537 0.00334871047316344 2.82871267406697 0.857142857142857 19.2 19 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00328701422648175 0.0104174192523018 2.75013732200955 0.833333333333333 19.2 19 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00328701422648175 0.0104174192523018 2.75013732200955 0.833333333333333 19.2 19 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.2058664381502e-09 5.56335114815578e-08 2.64013182912917 0.8 19.2 19 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000241853726460266 0.00106550418808965 2.64013182912917 0.8 19.2 19 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 7.99059149890411e-11 2.0304663755251e-09 2.64013182912917 0.8 19.2 19 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.000839477837530832 0.00321988399678268 2.56679483387558 0.777777777777778 19.2 19 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 1.72744690558344e-05 9.91192317195662e-05 2.47512358980859 0.75 19.2 19 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000216174209139144 0.000979668470079626 2.47512358980859 0.75 19.2 19 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.000216174209139144 0.000979668470079626 2.47512358980859 0.75 19.2 19 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.000216174209139144 0.000979668470079626 2.47512358980859 0.75 19.2 19 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000216174209139144 0.000979668470079626 2.47512358980859 0.75 19.2 19 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000216174209139144 0.000979668470079626 2.47512358980859 0.75 19.2 19 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00283926573678955 0.00920336023565268 2.47512358980859 0.75 19.2 19 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00283926573678955 0.00920336023565268 2.47512358980859 0.75 19.2 19 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00283926573678955 0.00920336023565268 2.47512358980859 0.75 19.2 19 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.04505693294476e-07 1.16180938717219e-06 2.4116588823776 0.730769230769231 19.2 19 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.04505693294476e-07 1.16180938717219e-06 2.4116588823776 0.730769230769231 19.2 19 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.000704835901320029 0.00272549317276739 2.40011984466288 0.727272727272727 19.2 19 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.00929139724280729 0.0264963091713723 2.35726056172247 0.714285714285714 19.2 19 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00929139724280729 0.0264963091713723 2.35726056172247 0.714285714285714 19.2 19 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00929139724280729 0.0264963091713723 2.35726056172247 0.714285714285714 19.2 19 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 4.62247982977676e-05 0.000250106037938112 2.32952808452574 0.705882352941177 19.2 19 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 1.20618600421921e-05 7.18160118830096e-05 2.31011535048802 0.7 19.2 19 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 1.20618600421921e-05 7.18160118830096e-05 2.31011535048802 0.7 19.2 19 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00223393409669549 0.007358537545365 2.31011535048802 0.7 19.2 19 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00223393409669549 0.007358537545365 2.31011535048802 0.7 19.2 19 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.00223393409669549 0.007358537545365 2.31011535048802 0.7 19.2 19 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000556862708438291 0.00221965163615599 2.28472946751563 0.692307692307692 19.2 19 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000556862708438291 0.00221965163615599 2.28472946751563 0.692307692307692 19.2 19 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000556862708438291 0.00221965163615599 2.28472946751563 0.692307692307692 19.2 19 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00014188068433071 0.00068007016553986 2.26886329065788 0.6875 19.2 19 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 3.66834168791436e-05 0.000203908211793052 2.25800748543942 0.684210526315789 19.2 19 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.27670696403757e-08 1.83510506042976e-07 2.22984107189963 0.675675675675676 19.2 19 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.43339568496438e-09 5.88641212012568e-08 2.22761123082773 0.675 19.2 19 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000109195129855891 0.000533967937405269 2.20010985760764 0.666666666666667 19.2 19 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000109195129855891 0.000533967937405269 2.20010985760764 0.666666666666667 19.2 19 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00683884153530697 0.0202743156348788 2.20010985760764 0.666666666666667 19.2 19 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00683884153530697 0.0202743156348788 2.20010985760764 0.666666666666667 19.2 19 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00683884153530697 0.0202743156348788 2.20010985760764 0.666666666666667 19.2 19 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00683884153530697 0.0202743156348788 2.20010985760764 0.666666666666667 19.2 19 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 1.39660318306337e-07 1.52874333038398e-06 2.20010985760764 0.666666666666667 19.2 19 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.23380436328393e-07 4.77416898009809e-06 2.20010985760764 0.666666666666667 19.2 19 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.45464484706845e-06 4.63828599500387e-05 2.20010985760764 0.666666666666667 19.2 19 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000424899608207907 0.00175765157697631 2.20010985760764 0.666666666666667 19.2 19 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0016821592856818 0.00574031813795014 2.20010985760764 0.666666666666667 19.2 19 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0016821592856818 0.00574031813795014 2.20010985760764 0.666666666666667 19.2 19 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0016821592856818 0.00574031813795014 2.20010985760764 0.666666666666667 19.2 19 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0016821592856818 0.00574031813795014 2.20010985760764 0.666666666666667 19.2 19 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 5.70499177094416e-06 3.94087538352114e-05 2.15780005265365 0.653846153846154 19.2 19 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 5.70499177094416e-06 3.94087538352114e-05 2.15780005265365 0.653846153846154 19.2 19 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 8.24091652906254e-05 0.000414670784949202 2.14510711116745 0.65 19.2 19 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 8.2877742519951e-08 9.43480220847122e-07 2.14064742902365 0.648648648648649 19.2 19 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 3.08429780702195e-07 2.96551066175151e-06 2.13540074414859 0.647058823529412 19.2 19 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.000317249808724437 0.00135977854763516 2.13540074414859 0.647058823529412 19.2 19 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.1511965198991e-06 9.57984004571003e-06 2.12913857187836 0.645161290322581 19.2 19 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.60865675932829e-09 7.71543361002842e-08 2.12677286235405 0.644444444444444 19.2 19 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 7.05909158506488e-11 1.82637951373588e-09 2.12153450555022 0.642857142857143 19.2 19 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 4.31192150071679e-06 3.05266880374129e-05 2.12153450555022 0.642857142857143 19.2 19 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00123681912510739 0.0043672298139648 2.12153450555022 0.642857142857143 19.2 19 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00123681912510739 0.0043672298139648 2.12153450555022 0.642857142857143 19.2 19 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00123681912510739 0.0043672298139648 2.12153450555022 0.642857142857143 19.2 19 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00123681912510739 0.0043672298139648 2.12153450555022 0.642857142857143 19.2 19 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00123681912510739 0.0043672298139648 2.12153450555022 0.642857142857143 19.2 19 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00123681912510739 0.0043672298139648 2.12153450555022 0.642857142857143 19.2 19 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00123681912510739 0.0043672298139648 2.12153450555022 0.642857142857143 19.2 19 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.62199435931254e-05 9.34452620769939e-05 2.11210546330333 0.64 19.2 19 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 1.62199435931254e-05 9.34452620769939e-05 2.11210546330333 0.64 19.2 19 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.33323651743141e-07 2.4317311017451e-06 2.10843861354065 0.638888888888889 19.2 19 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 8.66625983031563e-07 7.34052841579711e-06 2.10010486408002 0.636363636363636 19.2 19 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 6.13369693206539e-05 0.000320891571115038 2.10010486408002 0.636363636363636 19.2 19 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00490985593860254 0.0149608672390394 2.10010486408002 0.636363636363636 19.2 19 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00490985593860254 0.0149608672390394 2.10010486408002 0.636363636363636 19.2 19 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00490985593860254 0.0149608672390394 2.10010486408002 0.636363636363636 19.2 19 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 1.20545982612883e-05 7.18160118830096e-05 2.07788153218499 0.62962962962963 19.2 19 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 4.51919610130997e-05 0.000246889682413661 2.06260299150716 0.625 19.2 19 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000896597814669902 0.00334871047316344 2.06260299150716 0.625 19.2 19 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000896597814669902 0.00334871047316344 2.06260299150716 0.625 19.2 19 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000896597814669902 0.00334871047316344 2.06260299150716 0.625 19.2 19 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000896597814669902 0.00334871047316344 2.06260299150716 0.625 19.2 19 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000896597814669902 0.00334871047316344 2.06260299150716 0.625 19.2 19 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.000896597814669902 0.00334871047316344 2.06260299150716 0.625 19.2 19 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0200449497528368 0.0503068139299591 2.06260299150716 0.625 19.2 19 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0200449497528368 0.0503068139299591 2.06260299150716 0.625 19.2 19 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0200449497528368 0.0503068139299591 2.06260299150716 0.625 19.2 19 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0200449497528368 0.0503068139299591 2.06260299150716 0.625 19.2 19 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0200449497528368 0.0503068139299591 2.06260299150716 0.625 19.2 19 2 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.0200449497528368 0.0503068139299591 2.06260299150716 0.625 19.2 19 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0200449497528368 0.0503068139299591 2.06260299150716 0.625 19.2 19 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0200449497528368 0.0503068139299591 2.06260299150716 0.625 19.2 19 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.75234971301903e-12 1.50279858702802e-10 2.05662443211149 0.623188405797101 19.2 19 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000170167968061245 0.00079133666193187 2.04295915349281 0.619047619047619 19.2 19 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.96637137178812e-08 2.69052544428317e-07 2.03627188948792 0.617021276595745 19.2 19 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 4.00399347104945e-09 6.78295560631353e-08 2.03087063779167 0.615384615384615 19.2 19 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.00348263380927141 0.0110128620235405 2.03087063779167 0.615384615384615 19.2 19 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000644192875517867 0.00252530705747087 2.01676736947367 0.611111111111111 19.2 19 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000644192875517867 0.00252530705747087 2.01676736947367 0.611111111111111 19.2 19 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.26720675635725e-08 6.19440926801352e-07 2.00879595694611 0.608695652173913 19.2 19 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000123140484071602 0.000593996301131829 2.00879595694611 0.608695652173913 19.2 19 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000123140484071602 0.000593996301131829 2.00879595694611 0.608695652173913 19.2 19 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 4.75016486839512e-06 3.32979537326417e-05 2.0000998705524 0.606060606060606 19.2 19 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000460138560889852 0.00187615235571994 1.98009887184688 0.6 19.2 19 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0137462026932242 0.0360236582549872 1.98009887184688 0.6 19.2 19 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0137462026932242 0.0360236582549872 1.98009887184688 0.6 19.2 19 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0137462026932242 0.0360236582549872 1.98009887184688 0.6 19.2 19 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0137462026932242 0.0360236582549872 1.98009887184688 0.6 19.2 19 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0137462026932242 0.0360236582549872 1.98009887184688 0.6 19.2 19 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.25324950732336e-05 7.43072520383811e-05 1.9594728419318 0.59375 19.2 19 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.3573711232e-05 0.000330165660887358 1.95565320676235 0.592592592592593 19.2 19 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 6.3573711232e-05 0.000330165660887358 1.95565320676235 0.592592592592593 19.2 19 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.35328577390451e-08 8.43848843247268e-07 1.95315875114148 0.591836734693878 19.2 19 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000327368299575433 0.00139058235909206 1.95009737378859 0.590909090909091 19.2 19 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00172423782316343 0.00580045017106753 1.94127340377145 0.588235294117647 19.2 19 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.00172423782316343 0.00580045017106753 1.94127340377145 0.588235294117647 19.2 19 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00172423782316343 0.00580045017106753 1.94127340377145 0.588235294117647 19.2 19 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 4.5456849467589e-05 0.000246889682413661 1.93457935755154 0.586206896551724 19.2 19 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 4.5456849467589e-05 0.000246889682413661 1.93457935755154 0.586206896551724 19.2 19 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.29796170520369e-06 1.04943153778684e-05 1.93180377741159 0.585365853658537 19.2 19 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.29796170520369e-06 1.04943153778684e-05 1.93180377741159 0.585365853658537 19.2 19 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.16635649041694e-09 2.18384906034645e-08 1.92932710590208 0.584615384615385 19.2 19 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 6.46225756475438e-06 4.43227817113333e-05 1.92509612540668 0.583333333333333 19.2 19 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.68505537571588e-09 8.60394389846871e-08 1.92509612540668 0.583333333333333 19.2 19 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.68505537571588e-09 8.60394389846871e-08 1.92509612540668 0.583333333333333 19.2 19 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.68505537571588e-09 8.60394389846871e-08 1.92509612540668 0.583333333333333 19.2 19 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.68505537571588e-09 8.60394389846871e-08 1.92509612540668 0.583333333333333 19.2 19 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.68505537571588e-09 8.60394389846871e-08 1.92509612540668 0.583333333333333 19.2 19 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.68505537571588e-09 8.60394389846871e-08 1.92509612540668 0.583333333333333 19.2 19 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.68505537571588e-09 8.60394389846871e-08 1.92509612540668 0.583333333333333 19.2 19 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000232268416353506 0.00104926335387631 1.92509612540668 0.583333333333333 19.2 19 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0094286312526916 0.0267803238973656 1.92509612540668 0.583333333333333 19.2 19 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0094286312526916 0.0267803238973656 1.92509612540668 0.583333333333333 19.2 19 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 9.32872714280782e-07 7.80869336718561e-06 1.91870045721596 0.581395348837209 19.2 19 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00120889430950075 0.00435508000612549 1.91062171844874 0.578947368421053 19.2 19 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00120889430950075 0.00435508000612549 1.91062171844874 0.578947368421053 19.2 19 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000164476515280942 0.000769901583042039 1.90394122292969 0.576923076923077 19.2 19 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 9.80303980091422e-12 2.90619284097936e-10 1.90244793569602 0.576470588235294 19.2 19 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.44018353273424e-08 2.02909026443646e-07 1.90178987691508 0.576271186440678 19.2 19 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.44018353273424e-08 2.02909026443646e-07 1.90178987691508 0.576271186440678 19.2 19 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.72855974203487e-11 1.24606305794734e-09 1.89759475218659 0.575 19.2 19 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.28236679608413e-10 5.15525071559955e-09 1.89209447754257 0.573333333333333 19.2 19 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.28236679608413e-10 5.15525071559955e-09 1.89209447754257 0.573333333333333 19.2 19 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.28236679608413e-10 5.15525071559955e-09 1.89209447754257 0.573333333333333 19.2 19 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.28236679608413e-10 5.15525071559955e-09 1.89209447754257 0.573333333333333 19.2 19 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.28236679608413e-10 5.15525071559955e-09 1.89209447754257 0.573333333333333 19.2 19 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00647705338815678 0.0193631238893847 1.88580844937798 0.571428571428571 19.2 19 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00084676601799466 0.00323042370940054 1.88580844937798 0.571428571428571 19.2 19 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00084676601799466 0.00323042370940054 1.88580844937798 0.571428571428571 19.2 19 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.68261036965053e-06 1.3228478210015e-05 1.87509362864287 0.568181818181818 19.2 19 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.68261036965053e-06 1.3228478210015e-05 1.87509362864287 0.568181818181818 19.2 19 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.68261036965053e-06 1.3228478210015e-05 1.87509362864287 0.568181818181818 19.2 19 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.19854809789212e-06 9.91589501918885e-06 1.86531053144995 0.565217391304348 19.2 19 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000592864459730411 0.00233696987866032 1.86531053144995 0.565217391304348 19.2 19 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000592864459730411 0.00233696987866032 1.86531053144995 0.565217391304348 19.2 19 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000592864459730411 0.00233696987866032 1.86531053144995 0.565217391304348 19.2 19 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0044579705821824 0.0136717502983741 1.85634269235645 0.5625 19.2 19 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0044579705821824 0.0136717502983741 1.85634269235645 0.5625 19.2 19 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 6.91653491280082e-17 7.03016370065398e-15 1.8518910312237 0.561151079136691 19.2 19 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00029060502034212 0.0012724029044518 1.8334248813397 0.555555555555556 19.2 19 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.88750043270638e-05 0.000161387151680771 1.8334248813397 0.555555555555556 19.2 19 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00307429400772038 0.0097868464720047 1.8334248813397 0.555555555555556 19.2 19 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0365525850247492 0.0845761438865335 1.8334248813397 0.555555555555556 19.2 19 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.63073813024757e-08 2.26957186604096e-07 1.8224790611526 0.552238805970149 19.2 19 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.000203516677643167 0.000937571431205047 1.82078057181322 0.551724137931034 19.2 19 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.47881675477658e-06 1.18890183166501e-05 1.81845814761448 0.551020408163265 19.2 19 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.43594009555594e-05 8.40881792582759e-05 1.8150906325263 0.55 19.2 19 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.00212404022446963 0.00704547608256475 1.8150906325263 0.55 19.2 19 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00212404022446963 0.00704547608256475 1.8150906325263 0.55 19.2 19 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 5.85750727519936e-09 8.60394389846871e-08 1.80830947200628 0.547945205479452 19.2 19 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 7.40789369625859e-07 6.42770288400974e-06 1.80575054350816 0.547169811320755 19.2 19 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.16354416771844e-10 6.62018139803432e-09 1.80357842978301 0.546511627906977 19.2 19 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00147004328009773 0.00515239307285486 1.80008988349716 0.545454545454545 19.2 19 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0243498187987702 0.0594336057472555 1.80008988349716 0.545454545454545 19.2 19 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.09911127954727e-09 3.7337941884947e-08 1.7962922255151 0.544303797468354 19.2 19 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.09911127954727e-09 3.7337941884947e-08 1.7962922255151 0.544303797468354 19.2 19 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.09911127954727e-09 3.7337941884947e-08 1.7962922255151 0.544303797468354 19.2 19 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 7.00409832913816e-05 0.00035981342680013 1.79151802690908 0.542857142857143 19.2 19 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.54897112809525e-06 2.64407639543431e-05 1.78758925930621 0.541666666666667 19.2 19 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.65410812305264e-28 1.29994896477598e-25 1.78354493971502 0.540441176470588 19.2 19 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.31260028612587e-07 1.44793039314505e-06 1.78104131330142 0.53968253968254 19.2 19 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 4.38304142381907e-14 2.97003235528311e-12 1.77701180806771 0.538461538461538 19.2 19 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0163656282700151 0.0424968777887436 1.77701180806771 0.538461538461538 19.2 19 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0163656282700151 0.0424968777887436 1.77701180806771 0.538461538461538 19.2 19 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0163656282700151 0.0424968777887436 1.77701180806771 0.538461538461538 19.2 19 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.64276811104862e-08 2.26957186604096e-07 1.76008788608611 0.533333333333333 19.2 19 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.011074030516957 0.0308987165208426 1.76008788608611 0.533333333333333 19.2 19 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.011074030516957 0.0308987165208426 1.76008788608611 0.533333333333333 19.2 19 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.011074030516957 0.0308987165208426 1.76008788608611 0.533333333333333 19.2 19 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.011074030516957 0.0308987165208426 1.76008788608611 0.533333333333333 19.2 19 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.011074030516957 0.0308987165208426 1.76008788608611 0.533333333333333 19.2 19 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.011074030516957 0.0308987165208426 1.76008788608611 0.533333333333333 19.2 19 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.011074030516957 0.0308987165208426 1.76008788608611 0.533333333333333 19.2 19 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000238404847556867 0.00105475876620938 1.75321254278109 0.53125 19.2 19 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.8113954506533e-09 8.60394389846871e-08 1.75193933105793 0.530864197530864 19.2 19 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.8113954506533e-09 8.60394389846871e-08 1.75193933105793 0.530864197530864 19.2 19 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.14027766612413e-06 2.94580755944732e-05 1.7471460633943 0.529411764705882 19.2 19 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.14027766612413e-06 2.94580755944732e-05 1.7471460633943 0.529411764705882 19.2 19 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.000166258212401183 0.000775689954907814 1.7471460633943 0.529411764705882 19.2 19 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00753341993607873 0.0221488772087604 1.7471460633943 0.529411764705882 19.2 19 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00753341993607873 0.0221488772087604 1.7471460633943 0.529411764705882 19.2 19 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00753341993607873 0.0221488772087604 1.7471460633943 0.529411764705882 19.2 19 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000116050018604443 0.000563614936771747 1.74175363727271 0.527777777777778 19.2 19 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.89161034867268e-13 2.21510461046449e-11 1.73962174787581 0.527131782945736 19.2 19 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 7.27549029928749e-10 1.39905712106569e-08 1.73879650036733 0.526881720430108 19.2 19 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.68964119161581e-08 3.47941765060846e-07 1.7369288349534 0.526315789473684 19.2 19 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 8.10716147972633e-05 0.000410551273510696 1.7369288349534 0.526315789473684 19.2 19 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00514696033907551 0.0156498388087702 1.7369288349534 0.526315789473684 19.2 19 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 9.59199275416226e-18 1.13745047409774e-15 1.73123398631421 0.524590163934426 19.2 19 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00352904185159207 0.0111102357407423 1.72865774526315 0.523809523809524 19.2 19 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00352904185159207 0.0111102357407423 1.72865774526315 0.523809523809524 19.2 19 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.49495952814325e-07 2.4317311017451e-06 1.72396667946867 0.522388059701492 19.2 19 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.49495952814325e-07 2.4317311017451e-06 1.72396667946867 0.522388059701492 19.2 19 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.11972198843009e-15 2.61139081737412e-13 1.72365294576904 0.522292993630573 19.2 19 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.20952772091025e-15 1.96509871678455e-13 1.72272753001353 0.522012578616352 19.2 19 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 1.36298144223262e-05 8.04781158629467e-05 1.71883582625597 0.520833333333333 19.2 19 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.73307777863193e-08 9.86283307856606e-07 1.71789399840596 0.520547945205479 19.2 19 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 9.55797509221516e-06 5.78765896009454e-05 1.71608568893396 0.52 19.2 19 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00167332199142809 0.00574031813795014 1.71608568893396 0.52 19.2 19 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00167332199142809 0.00574031813795014 1.71608568893396 0.52 19.2 19 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00167332199142809 0.00574031813795014 1.71608568893396 0.52 19.2 19 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00167332199142809 0.00574031813795014 1.71608568893396 0.52 19.2 19 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00167332199142809 0.00574031813795014 1.71608568893396 0.52 19.2 19 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00115625128510002 0.00419731014973807 1.71119655591705 0.518518518518518 19.2 19 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00115625128510002 0.00419731014973807 1.71119655591705 0.518518518518518 19.2 19 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.63167105528647e-06 1.30442017509699e-05 1.70508513964592 0.516666666666667 19.2 19 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 8.06619052921284e-07 6.8731671395628e-06 1.70164746799341 0.515625 19.2 19 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 3.99242090287152e-07 3.78747662985745e-06 1.69861422830002 0.514705882352941 19.2 19 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.25424547309745e-19 8.09071937110697e-17 1.69722760444018 0.514285714285714 19.2 19 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.26687292006701e-14 9.48821139608079e-13 1.69133445303587 0.5125 19.2 19 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.05202969543045e-11 5.50950614452365e-10 1.69099352692157 0.512396694214876 19.2 19 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.05202969543045e-11 5.50950614452365e-10 1.69099352692157 0.512396694214876 19.2 19 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 9.07970853874336e-05 0.000450189033123059 1.69032830523514 0.51219512195122 19.2 19 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.08685460704278e-22 2.57765684303646e-20 1.68816121766432 0.511538461538461 19.2 19 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.06459382615885e-05 6.41913989247476e-05 1.68121602326621 0.509433962264151 19.2 19 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 8.94938979729341e-07 7.53549211925948e-06 1.67471048862671 0.507462686567164 19.2 19 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 6.2925739431412e-07 5.66729919056324e-06 1.67399663078842 0.507246376811594 19.2 19 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.31066066974189e-19 6.1340701330427e-17 1.67228081105155 0.506726457399103 19.2 19 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.79634134826777e-08 4.57813028693647e-07 1.66949512724344 0.505882352941176 19.2 19 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.79634134826777e-08 4.57813028693647e-07 1.66949512724344 0.505882352941176 19.2 19 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.79634134826777e-08 4.57813028693647e-07 1.66949512724344 0.505882352941176 19.2 19 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.79634134826777e-08 4.57813028693647e-07 1.66949512724344 0.505882352941176 19.2 19 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.06101638559475e-10 8.13919199535398e-09 1.66494800035173 0.504504504504504 19.2 19 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.12306536970137e-12 1.43358774873711e-10 1.66195348955973 0.503597122302158 19.2 19 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.28210073914444e-15 3.38523852877919e-13 1.65940489260237 0.502824858757062 19.2 19 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 6.01357021614341e-13 3.1693742287304e-11 1.65008239320573 0.5 19.2 19 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.09319812308732e-09 8.42746619668984e-08 1.65008239320573 0.5 19.2 19 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 6.87351021730211e-07 6.00061658847908e-06 1.65008239320573 0.5 19.2 19 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000420220538430445 0.00174336392474205 1.65008239320573 0.5 19.2 19 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.001820789359311 0.0061108095714612 1.65008239320573 0.5 19.2 19 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0119925458644371 0.0324437124811672 1.65008239320573 0.5 19.2 19 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0119925458644371 0.0324437124811672 1.65008239320573 0.5 19.2 19 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0119925458644371 0.0324437124811672 1.65008239320573 0.5 19.2 19 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0262542031518734 0.0636451977599929 1.65008239320573 0.5 19.2 19 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0262542031518734 0.0636451977599929 1.65008239320573 0.5 19.2 19 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.92295587810484e-08 3.70323916287496e-07 1.65008239320573 0.5 19.2 19 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.88684304697945e-08 6.81055093971687e-07 1.65008239320573 0.5 19.2 19 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 8.14976382536962e-06 4.99875600150904e-05 1.65008239320573 0.5 19.2 19 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 8.14976382536962e-06 4.99875600150904e-05 1.65008239320573 0.5 19.2 19 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 4.83594838132901e-05 0.00025968130364646 1.65008239320573 0.5 19.2 19 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 4.83594838132901e-05 0.00025968130364646 1.65008239320573 0.5 19.2 19 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 6.91833635945818e-05 0.000356695385489456 1.65008239320573 0.5 19.2 19 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 6.91833635945818e-05 0.000356695385489456 1.65008239320573 0.5 19.2 19 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 9.90525020903735e-05 0.000489415661370144 1.65008239320573 0.5 19.2 19 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000141940154016401 0.00068007016553986 1.65008239320573 0.5 19.2 19 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000203590704316486 0.000937571431205047 1.65008239320573 0.5 19.2 19 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00383490783909376 0.0119935689121548 1.65008239320573 0.5 19.2 19 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00383490783909376 0.0119935689121548 1.65008239320573 0.5 19.2 19 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00558804042308643 0.0169186840894723 1.65008239320573 0.5 19.2 19 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00816988045368143 0.0237745191934329 1.65008239320573 0.5 19.2 19 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00816988045368143 0.0237745191934329 1.65008239320573 0.5 19.2 19 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0176900904517315 0.0453567544375026 1.65008239320573 0.5 19.2 19 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0176900904517315 0.0453567544375026 1.65008239320573 0.5 19.2 19 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0176900904517315 0.0453567544375026 1.65008239320573 0.5 19.2 19 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0392710063448488 0.0894122272459517 1.65008239320573 0.5 19.2 19 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0392710063448488 0.0894122272459517 1.65008239320573 0.5 19.2 19 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0392710063448488 0.0894122272459517 1.65008239320573 0.5 19.2 19 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0593589673562742 0.122772980447643 1.65008239320573 0.5 19.2 19 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0593589673562742 0.122772980447643 1.65008239320573 0.5 19.2 19 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0593589673562742 0.122772980447643 1.65008239320573 0.5 19.2 19 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 8.441473981074e-11 2.10740657457339e-09 1.63708961845608 0.496062992125984 19.2 19 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.22734266174257e-08 2.9901024600563e-07 1.6327131048562 0.494736842105263 19.2 19 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.22734266174257e-08 2.9901024600563e-07 1.6327131048562 0.494736842105263 19.2 19 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.59968446628799e-11 4.46343332456432e-10 1.6265097875885 0.492857142857143 19.2 19 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.59968446628799e-11 4.46343332456432e-10 1.6265097875885 0.492857142857143 19.2 19 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.13026067331877e-06 1.64747877072424e-05 1.62616815562304 0.492753623188406 19.2 19 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.13026067331877e-06 1.64747877072424e-05 1.62616815562304 0.492753623188406 19.2 19 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.57700038729721e-10 5.4732411210805e-09 1.62346816105725 0.491935483870968 19.2 19 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.57700038729721e-10 5.4732411210805e-09 1.62346816105725 0.491935483870968 19.2 19 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.57700038729721e-10 5.4732411210805e-09 1.62346816105725 0.491935483870968 19.2 19 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 3.64861207579126e-10 7.52460142587097e-09 1.62303186216957 0.491803278688525 19.2 19 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.46735690513276e-09 2.71175178701808e-08 1.62113357928984 0.491228070175439 19.2 19 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.38502896038959e-08 3.17186561741532e-07 1.61640724232398 0.489795918367347 19.2 19 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.5237164144649e-14 1.79562422889177e-12 1.61421103683169 0.489130434782609 19.2 19 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.000151410214302866 0.00072059108679926 1.61341389557894 0.488888888888889 19.2 19 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000151410214302866 0.00072059108679926 1.61341389557894 0.488888888888889 19.2 19 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000311013198534633 0.00133707486862472 1.60983648117632 0.48780487804878 19.2 19 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000311013198534633 0.00133707486862472 1.60983648117632 0.48780487804878 19.2 19 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000311013198534633 0.00133707486862472 1.60983648117632 0.48780487804878 19.2 19 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000311013198534633 0.00133707486862472 1.60983648117632 0.48780487804878 19.2 19 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000311013198534633 0.00133707486862472 1.60983648117632 0.48780487804878 19.2 19 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000311013198534633 0.00133707486862472 1.60983648117632 0.48780487804878 19.2 19 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 7.89091908305152e-07 6.80531991223171e-06 1.60777258825174 0.487179487179487 19.2 19 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000446405125141898 0.00182538647435897 1.60777258825174 0.487179487179487 19.2 19 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.000446405125141898 0.00182538647435897 1.60777258825174 0.487179487179487 19.2 19 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.000446405125141898 0.00182538647435897 1.60777258825174 0.487179487179487 19.2 19 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.26403432692369e-06 1.73210798237227e-05 1.60424677117224 0.486111111111111 19.2 19 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 3.21896158623175e-06 2.43647996659988e-05 1.60293718197128 0.485714285714286 19.2 19 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 9.26983217301934e-06 5.63716717188313e-05 1.59851731841805 0.484375 19.2 19 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 6.39043778179274e-13 3.24771177267538e-11 1.59252137948925 0.482558139534884 19.2 19 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 4.1311106881309e-07 3.86748059816465e-06 1.59184419109259 0.482352941176471 19.2 19 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 4.1311106881309e-07 3.86748059816465e-06 1.59184419109259 0.482352941176471 19.2 19 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 5.44703250939603e-05 0.000288799438810699 1.58896823049441 0.481481481481481 19.2 19 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00401631313140904 0.0125059378249345 1.58896823049441 0.481481481481481 19.2 19 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.08572131247723e-12 1.57325683209893e-10 1.58820430346051 0.48125 19.2 19 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.66582428764517e-08 3.47941765060846e-07 1.58661768577474 0.480769230769231 19.2 19 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 5.34566469707867e-08 6.23514824913356e-07 1.5840790974775 0.48 19.2 19 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00583021785232361 0.0175771186522384 1.5840790974775 0.48 19.2 19 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000158608567630635 0.000747350966021172 1.58132896015549 0.479166666666667 19.2 19 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00848569231712542 0.0244931849234675 1.57833968045765 0.478260869565217 19.2 19 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00848569231712542 0.0244931849234675 1.57833968045765 0.478260869565217 19.2 19 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 6.12553942103422e-07 5.55200165358707e-06 1.57333437491709 0.476744186046512 19.2 19 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.96103423898449e-05 0.000111177359445216 1.57150704114831 0.476190476190476 19.2 19 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000464715966278477 0.00188940234289792 1.57150704114831 0.476190476190476 19.2 19 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.012388824637399 0.0333156703718283 1.57150704114831 0.476190476190476 19.2 19 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.2310823990116e-06 1.00679899643305e-05 1.56959056914691 0.475609756097561 19.2 19 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.61689278306675e-15 1.53389228686932e-13 1.56868819443773 0.475336322869955 19.2 19 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000666094363031558 0.00259685555779153 1.56757827354544 0.475 19.2 19 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0181535728372625 0.0462120467753569 1.56323595145806 0.473684210526316 19.2 19 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.08995888326547e-08 4.89076595872837e-07 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.0704648267552e-06 4.43227817113333e-05 1.55841114913874 0.472222222222222 19.2 19 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00016367603710678 0.000768683170966823 1.55301872301716 0.470588235294118 19.2 19 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0019737564244338 0.00657764728798432 1.55301872301716 0.470588235294118 19.2 19 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0267182420212007 0.0645501840342421 1.55301872301716 0.470588235294118 19.2 19 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.55339240946742e-06 1.94303604207066e-05 1.54822545535352 0.469135802469136 19.2 19 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000333268299771352 0.00140724270200188 1.54475798512877 0.468085106382979 19.2 19 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00409805158296006 0.0126627467859064 1.54007690032535 0.466666666666667 19.2 19 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00409805158296006 0.0126627467859064 1.54007690032535 0.466666666666667 19.2 19 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0395368542074254 0.0898737117207129 1.54007690032535 0.466666666666667 19.2 19 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 8.24679073370514e-05 0.000414670784949202 1.5362836074674 0.46551724137931 19.2 19 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 4.6190923536175e-12 1.50279858702802e-10 1.53286342538237 0.46448087431694 19.2 19 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00591910040056068 0.0177323786736797 1.53221936511961 0.464285714285714 19.2 19 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00591910040056068 0.0177323786736797 1.53221936511961 0.464285714285714 19.2 19 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.67238175238456e-07 5.93073228856153e-06 1.52849737475899 0.463157894736842 19.2 19 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00856533631158428 0.0245735354261783 1.52315297834375 0.461538461538462 19.2 19 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00856533631158428 0.0245735354261783 1.52315297834375 0.461538461538462 19.2 19 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00856533631158428 0.0245735354261783 1.52315297834375 0.461538461538462 19.2 19 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.058904187551849 0.122365925381432 1.52315297834375 0.461538461538462 19.2 19 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.058904187551849 0.122365925381432 1.52315297834375 0.461538461538462 19.2 19 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.058904187551849 0.122365925381432 1.52315297834375 0.461538461538462 19.2 19 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.058904187551849 0.122365925381432 1.52315297834375 0.461538461538462 19.2 19 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.87946347109843e-06 1.46949259306213e-05 1.52030063194236 0.460674157303371 19.2 19 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 8.35638760150012e-05 0.000416146858676106 1.51482973802493 0.459016393442623 19.2 19 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.74844524669646e-06 2.71500416362837e-05 1.51419325494173 0.458823529411765 19.2 19 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.74844524669646e-06 2.71500416362837e-05 1.51419325494173 0.458823529411765 19.2 19 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.74844524669646e-06 2.71500416362837e-05 1.51419325494173 0.458823529411765 19.2 19 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.74844524669646e-06 2.71500416362837e-05 1.51419325494173 0.458823529411765 19.2 19 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.74844524669646e-06 2.71500416362837e-05 1.51419325494173 0.458823529411765 19.2 19 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0124209714908445 0.0333156703718283 1.51257552710525 0.458333333333333 19.2 19 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0124209714908445 0.0333156703718283 1.51257552710525 0.458333333333333 19.2 19 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0028587192279706 0.0092035236683307 1.50864675950238 0.457142857142857 19.2 19 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0028587192279706 0.0092035236683307 1.50864675950238 0.457142857142857 19.2 19 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0028587192279706 0.0092035236683307 1.50864675950238 0.457142857142857 19.2 19 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 7.47551888560139e-06 4.63828599500387e-05 1.50748268021264 0.45679012345679 19.2 19 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000685280897003567 0.00265709731998931 1.50659696770958 0.456521739130435 19.2 19 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.54819605693097e-10 1.09653930402955e-08 1.50387256089636 0.455696202531646 19.2 19 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.1448963550207e-21 4.36026787599207e-19 1.5000749029143 0.454545454545455 19.2 19 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 2.46753119926399e-07 2.4317311017451e-06 1.5000749029143 0.454545454545455 19.2 19 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 3.77772891355178e-06 2.71500416362837e-05 1.5000749029143 0.454545454545455 19.2 19 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.77772891355178e-06 2.71500416362837e-05 1.5000749029143 0.454545454545455 19.2 19 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000238673452367829 0.00105475876620938 1.5000749029143 0.454545454545455 19.2 19 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000238673452367829 0.00105475876620938 1.5000749029143 0.454545454545455 19.2 19 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0180561448159928 0.0460464051490284 1.5000749029143 0.454545454545455 19.2 19 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0180561448159928 0.0460464051490284 1.5000749029143 0.454545454545455 19.2 19 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0885332578208608 0.169331755213824 1.5000749029143 0.454545454545455 19.2 19 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0885332578208608 0.169331755213824 1.5000749029143 0.454545454545455 19.2 19 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0885332578208608 0.169331755213824 1.5000749029143 0.454545454545455 19.2 19 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0885332578208608 0.169331755213824 1.5000749029143 0.454545454545455 19.2 19 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0885332578208608 0.169331755213824 1.5000749029143 0.454545454545455 19.2 19 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0885332578208608 0.169331755213824 1.5000749029143 0.454545454545455 19.2 19 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0885332578208608 0.169331755213824 1.5000749029143 0.454545454545455 19.2 19 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0885332578208608 0.169331755213824 1.5000749029143 0.454545454545455 19.2 19 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00410226723000902 0.0126627467859064 1.5000749029143 0.454545454545455 19.2 19 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.000338754511649582 0.0014177872649334 1.4944142429033 0.452830188679245 19.2 19 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00589299991201931 0.0177288348304513 1.49039700031485 0.451612903225806 19.2 19 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0263220484238288 0.0637011478012047 1.48507415388516 0.45 19.2 19 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000682778310339192 0.00265462714648271 1.48170663879698 0.448979591836735 19.2 19 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.49687827723746e-06 4.63828599500387e-05 1.47938421459824 0.448275862068966 19.2 19 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000237839210321197 0.00105475876620938 1.47938421459824 0.448275862068966 19.2 19 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00847525505895161 0.0244931849234675 1.47938421459824 0.448275862068966 19.2 19 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00847525505895161 0.0244931849234675 1.47938421459824 0.448275862068966 19.2 19 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 8.36387923973059e-05 0.000416146858676106 1.47768572525886 0.447761194029851 19.2 19 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.17133259167461e-08 1.70082273260507e-07 1.47699682748485 0.447552447552448 19.2 19 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00283467853982499 0.00920336023565268 1.47638950971039 0.447368421052632 19.2 19 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000969598763998823 0.00357445347453452 1.47454171307746 0.446808510638298 19.2 19 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.1732926851071e-05 0.000229289401193336 1.47169510745376 0.445945945945946 19.2 19 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.1732926851071e-05 0.000229289401193336 1.47169510745376 0.445945945945946 19.2 19 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.48386546992741e-05 8.6538547692898e-05 1.4711577963521 0.44578313253012 19.2 19 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 5.30039092356923e-06 3.69728249227403e-05 1.47072561133554 0.445652173913043 19.2 19 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000476318372162868 0.00192557114655614 1.46673990507176 0.444444444444444 19.2 19 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000476318372162868 0.00192557114655614 1.46673990507176 0.444444444444444 19.2 19 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00404761788297436 0.0125758957368396 1.46673990507176 0.444444444444444 19.2 19 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0384987989466116 0.0882186648969859 1.46673990507176 0.444444444444444 19.2 19 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0384987989466116 0.0882186648969859 1.46673990507176 0.444444444444444 19.2 19 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 8.27931274943524e-05 0.000414840212762195 1.46150154826793 0.442857142857143 19.2 19 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000235168528751989 0.00105234218998138 1.46072867595261 0.442622950819672 19.2 19 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000235168528751989 0.00105234218998138 1.46072867595261 0.442622950819672 19.2 19 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 5.8649512168058e-09 8.60394389846871e-08 1.45968827091276 0.442307692307692 19.2 19 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.00195629312097013 0.00653475378201995 1.45821234748413 0.441860465116279 19.2 19 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0057826704975684 0.0174707858132481 1.45595505282858 0.441176470588235 19.2 19 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 6.81706920659843e-12 2.06397648531693e-10 1.45507265582687 0.440909090909091 19.2 19 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000331830967298264 0.00140534365019473 1.45430990587624 0.440677966101695 19.2 19 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.3360551806656e-13 1.38508605086965e-11 1.45364401306219 0.44047619047619 19.2 19 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.3360551806656e-13 1.38508605086965e-11 1.45364401306219 0.44047619047619 19.2 19 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.3360551806656e-13 1.38508605086965e-11 1.45364401306219 0.44047619047619 19.2 19 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.37244526049524e-07 3.220798393077e-06 1.44885283305869 0.439024390243902 19.2 19 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.89203961198851e-05 0.000161387151680771 1.44885283305869 0.439024390243902 19.2 19 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00277940985931946 0.00909218443634847 1.44885283305869 0.439024390243902 19.2 19 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00277940985931946 0.00909218443634847 1.44885283305869 0.439024390243902 19.2 19 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.83094194524511e-10 7.78775769726257e-09 1.44713108281144 0.438502673796791 19.2 19 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0565287815729648 0.118469007626405 1.44382209405501 0.4375 19.2 19 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.92410382395132e-42 7.00699974148272e-39 1.44102218049188 0.436651583710407 19.2 19 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.000114435455179345 0.000557676892877423 1.44091701941909 0.436619718309859 19.2 19 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000660301535875158 0.00258134364162184 1.44007190679773 0.436363636363636 19.2 19 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.00394933887961288 0.0123243623370375 1.43853336843576 0.435897435897436 19.2 19 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.62826119989588e-07 4.24904237900119e-06 1.43716853601789 0.435483870967742 19.2 19 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.000324967812037993 0.00138451855248522 1.43716853601789 0.435483870967742 19.2 19 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.65778139328113e-25 1.04100458452781e-22 1.43676375682172 0.435361216730038 19.2 19 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 8.55748358635348e-37 4.05909971446034e-34 1.43669145631229 0.435339308578745 19.2 19 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.45530695338829e-07 5.77729672620852e-06 1.43367814491645 0.434426229508197 19.2 19 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 7.97509557243998e-05 0.000405305749985075 1.43296628883655 0.434210526315789 19.2 19 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 7.97509557243998e-05 0.000405305749985075 1.43296628883655 0.434210526315789 19.2 19 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000931104564973441 0.00345943027665067 1.43214698278233 0.433962264150943 19.2 19 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0118225283052981 0.032368405387091 1.43007140744497 0.433333333333333 19.2 19 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 4.53252131461838e-07 4.18816742253374e-06 1.42920522246166 0.433070866141732 19.2 19 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 5.79461421950361e-13 3.1693742287304e-11 1.42880697649232 0.432950191570881 19.2 19 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.94073102884659e-08 3.70323916287496e-07 1.4265228431585 0.432258064516129 19.2 19 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.85227838013759e-20 7.67199126103977e-18 1.42542328802748 0.431924882629108 19.2 19 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.47792349233672e-06 2.60478164715534e-05 1.42300683450769 0.431192660550459 19.2 19 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 3.47792349233672e-06 2.60478164715534e-05 1.42300683450769 0.431192660550459 19.2 19 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.000156511564642688 0.000739920121217759 1.42090428303827 0.430555555555556 19.2 19 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.22317783992492e-06 1.00611680127928e-05 1.41825263548261 0.429752066115702 19.2 19 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000903090295881168 0.00336412955769346 1.41435633703348 0.428571428571429 19.2 19 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0169186456970974 0.043693707489963 1.41435633703348 0.428571428571429 19.2 19 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0169186456970974 0.043693707489963 1.41435633703348 0.428571428571429 19.2 19 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0169186456970974 0.043693707489963 1.41435633703348 0.428571428571429 19.2 19 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.083391675851831 0.165043608813846 1.41435633703348 0.428571428571429 19.2 19 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.083391675851831 0.165043608813846 1.41435633703348 0.428571428571429 19.2 19 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.083391675851831 0.165043608813846 1.41435633703348 0.428571428571429 19.2 19 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.083391675851831 0.165043608813846 1.41435633703348 0.428571428571429 19.2 19 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.083391675851831 0.165043608813846 1.41435633703348 0.428571428571429 19.2 19 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.083391675851831 0.165043608813846 1.41435633703348 0.428571428571429 19.2 19 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.3807425498843e-10 5.29343226325838e-09 1.41435633703348 0.428571428571429 19.2 19 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000443714854492201 0.00182538647435897 1.41435633703348 0.428571428571429 19.2 19 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00184967331383553 0.00619314147197168 1.41435633703348 0.428571428571429 19.2 19 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0367719662636511 0.0849456298590512 1.41435633703348 0.428571428571429 19.2 19 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00797563394976682 0.0233045731222139 1.41435633703348 0.428571428571429 19.2 19 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 5.23434461520908e-05 0.000278969003275001 1.40351835743936 0.425287356321839 19.2 19 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 5.23434461520908e-05 0.000278969003275001 1.40351835743936 0.425287356321839 19.2 19 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.00540032170173785 0.0163851978285138 1.40257003422487 0.425 19.2 19 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 8.05818948400774e-07 6.8731671395628e-06 1.40006990938668 0.424242424242424 19.2 19 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.55782576406357e-08 3.37017227987264e-07 1.39771685071544 0.423529411764706 19.2 19 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0242244160538114 0.0594336057472555 1.39622356348177 0.423076923076923 19.2 19 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0242244160538114 0.0594336057472555 1.39622356348177 0.423076923076923 19.2 19 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.21867684606275e-06 1.70658224429583e-05 1.39519161701948 0.422764227642276 19.2 19 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00121941751911184 0.0043672298139648 1.38954306796272 0.421052631578947 19.2 19 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00763226272298928 0.0223932161954923 1.38954306796272 0.421052631578947 19.2 19 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0532953270261383 0.115709976630364 1.38954306796272 0.421052631578947 19.2 19 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0532953270261383 0.115709976630364 1.38954306796272 0.421052631578947 19.2 19 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0532953270261383 0.115709976630364 1.38954306796272 0.421052631578947 19.2 19 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.71972867209736e-08 5.59681158366212e-07 1.38645976233854 0.420118343195266 19.2 19 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00249840338684688 0.00821068826670465 1.38606921029281 0.42 19.2 19 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000836351806898026 0.00321656384112403 1.38394007172093 0.419354838709677 19.2 19 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00170568832873599 0.00577903450426505 1.38006891068116 0.418181818181818 19.2 19 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00170568832873599 0.00577903450426505 1.38006891068116 0.418181818181818 19.2 19 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00170568832873599 0.00577903450426505 1.38006891068116 0.418181818181818 19.2 19 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.000195951215236392 0.000908268987887249 1.37854984748833 0.417721518987342 19.2 19 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.000395086386460845 0.00164388283021574 1.37506866100477 0.416666666666667 19.2 19 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000395086386460845 0.00164388283021574 1.37506866100477 0.416666666666667 19.2 19 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0107813597117613 0.0305007452680644 1.37506866100477 0.416666666666667 19.2 19 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00116688398908806 0.00422512955845373 1.37506866100477 0.416666666666667 19.2 19 2 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.123720580303727 0.223598885747484 1.37506866100477 0.416666666666667 19.2 19 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.123720580303727 0.223598885747484 1.37506866100477 0.416666666666667 19.2 19 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.123720580303727 0.223598885747484 1.37506866100477 0.416666666666667 19.2 19 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.123720580303727 0.223598885747484 1.37506866100477 0.416666666666667 19.2 19 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.88894044371825e-12 8.95987417137022e-11 1.37413004758429 0.416382252559727 19.2 19 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0228786861475532 0.0571164392771372 1.36558542885991 0.413793103448276 19.2 19 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0228786861475532 0.0571164392771372 1.36558542885991 0.413793103448276 19.2 19 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 4.45094021595702e-07 4.13966531196525e-06 1.36264868600215 0.412903225806452 19.2 19 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00111225885453455 0.00406875154242329 1.36197276899521 0.412698412698413 19.2 19 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0773961592591997 0.155220125812085 1.35889138264001 0.411764705882353 19.2 19 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0773961592591997 0.155220125812085 1.35889138264001 0.411764705882353 19.2 19 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0773961592591997 0.155220125812085 1.35889138264001 0.411764705882353 19.2 19 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.96128542185576e-07 2.86660486755153e-06 1.35650945208324 0.411042944785276 19.2 19 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000522891868260953 0.00210190714275519 1.35623210400471 0.410958904109589 19.2 19 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.88623084376249e-05 0.00031022616632126 1.3530675624287 0.41 19.2 19 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.81573089998203e-05 0.000158370951410056 1.35006741262287 0.409090909090909 19.2 19 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.81573089998203e-05 0.000158370951410056 1.35006741262287 0.409090909090909 19.2 19 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0497290734197221 0.109216785394071 1.35006741262287 0.409090909090909 19.2 19 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0497290734197221 0.109216785394071 1.35006741262287 0.409090909090909 19.2 19 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0497290734197221 0.109216785394071 1.35006741262287 0.409090909090909 19.2 19 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.000723822356749196 0.00279132578226045 1.34795463106947 0.408450704225352 19.2 19 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0324880706274961 0.0766315348565977 1.34451157964911 0.407407407407407 19.2 19 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0324880706274961 0.0766315348565977 1.34451157964911 0.407407407407407 19.2 19 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0324880706274961 0.0766315348565977 1.34451157964911 0.407407407407407 19.2 19 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0324880706274961 0.0766315348565977 1.34451157964911 0.407407407407407 19.2 19 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00146346322079089 0.0051419954646554 1.34069194447966 0.40625 19.2 19 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 8.23155319066793e-10 1.56180002537606e-08 1.338621057942 0.405622489959839 19.2 19 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0143057681897033 0.0373524919888951 1.33790464313978 0.405405405405405 19.2 19 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0143057681897033 0.0373524919888951 1.33790464313978 0.405405405405405 19.2 19 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000105725840001495 0.000520580866166528 1.3333999137016 0.404040404040404 19.2 19 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 7.29761369074712e-05 0.000373543319493998 1.33275885605078 0.403846153846154 19.2 19 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0712775127610112 0.144897000941313 1.32006591456458 0.4 19.2 19 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0712775127610112 0.144897000941313 1.32006591456458 0.4 19.2 19 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0712775127610112 0.144897000941313 1.32006591456458 0.4 19.2 19 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0712775127610112 0.144897000941313 1.32006591456458 0.4 19.2 19 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0712775127610112 0.144897000941313 1.32006591456458 0.4 19.2 19 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0302494580423899 0.0719815698901687 1.32006591456458 0.4 19.2 19 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.112628223614768 0.205474310517711 1.32006591456458 0.4 19.2 19 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.112628223614768 0.205474310517711 1.32006591456458 0.4 19.2 19 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.112628223614768 0.205474310517711 1.32006591456458 0.4 19.2 19 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.41084593495746e-05 8.29600729522507e-05 1.31510326075043 0.398496240601504 19.2 19 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000575281117738879 0.00228666209648722 1.31211371025998 0.397590361445783 19.2 19 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.92125932640379e-05 0.000109358080858904 1.30998907552211 0.396946564885496 19.2 19 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.92125932640379e-05 0.000109358080858904 1.30998907552211 0.396946564885496 19.2 19 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0124924593832726 0.0333156703718283 1.30471631090686 0.395348837209302 19.2 19 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.45938503443979e-05 0.000288799438810699 1.30342642824654 0.394957983193277 19.2 19 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0280557737778968 0.0673243947486462 1.30006491585906 0.393939393939394 19.2 19 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0280557737778968 0.0673243947486462 1.30006491585906 0.393939393939394 19.2 19 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0280557737778968 0.0673243947486462 1.30006491585906 0.393939393939394 19.2 19 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 4.97885529237783e-17 5.44993160081051e-15 1.29781761263372 0.393258426966292 19.2 19 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0425624044059894 0.0946348460464422 1.29649330894736 0.392857142857143 19.2 19 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.0078414865008052 0.0229597433963905 1.29418226918096 0.392156862745098 19.2 19 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0116246379519489 0.032308319932858 1.29136882946535 0.391304347826087 19.2 19 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0116246379519489 0.032308319932858 1.29136882946535 0.391304347826087 19.2 19 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 6.75178236645796e-07 5.93073228856153e-06 1.28912686969198 0.390625 19.2 19 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.75178236645796e-07 5.93073228856153e-06 1.28912686969198 0.390625 19.2 19 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 4.4299900770303e-06 3.12073063347233e-05 1.28786918494106 0.390243902439024 19.2 19 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0259477285372214 0.0631172952281472 1.28339741693779 0.388888888888889 19.2 19 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.102149024912665 0.189515074903158 1.28339741693779 0.388888888888889 19.2 19 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.102149024912665 0.189515074903158 1.28339741693779 0.388888888888889 19.2 19 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000940414762655861 0.00347587066820595 1.28124044648915 0.388235294117647 19.2 19 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000940414762655861 0.00347587066820595 1.28124044648915 0.388235294117647 19.2 19 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0391828217671277 0.0894122272459517 1.27748314312702 0.387096774193548 19.2 19 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00428295468545488 0.0131918712497885 1.26929414861979 0.384615384615385 19.2 19 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0597773241308215 0.123279901794433 1.26929414861979 0.384615384615385 19.2 19 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0597773241308215 0.123279901794433 1.26929414861979 0.384615384615385 19.2 19 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.16423082577365 0.273974753899067 1.26929414861979 0.384615384615385 19.2 19 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.000337728057209196 0.00141766084191353 1.26454912376514 0.383177570093458 19.2 19 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.000337728057209196 0.00141766084191353 1.26454912376514 0.383177570093458 19.2 19 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00160893729624939 0.00561156316804628 1.25720563291865 0.380952380952381 19.2 19 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00160893729624939 0.00561156316804628 1.25720563291865 0.380952380952381 19.2 19 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0925116952209253 0.173215976709706 1.25720563291865 0.380952380952381 19.2 19 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0925116952209253 0.173215976709706 1.25720563291865 0.380952380952381 19.2 19 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0925116952209253 0.173215976709706 1.25720563291865 0.380952380952381 19.2 19 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.0136892647440782 0.0360236582549872 1.25406261883635 0.38 19.2 19 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.92146762082601e-08 3.70323916287496e-07 1.250964991239 0.379061371841155 19.2 19 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0330341391835368 0.0776984794349966 1.2487110002638 0.378378378378378 19.2 19 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 2.78931938365314e-09 4.90024874436842e-08 1.24515419855402 0.377300613496933 19.2 19 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.80906493275268e-05 0.000210906591412726 1.2401893146387 0.375796178343949 19.2 19 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.63077078663163e-38 1.1602934146884e-35 1.23995862213781 0.375726275016139 19.2 19 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.000489490999995017 0.00197321726060314 1.2375617949043 0.375 19.2 19 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0498114502605425 0.109216785394071 1.2375617949043 0.375 19.2 19 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0498114502605425 0.109216785394071 1.2375617949043 0.375 19.2 19 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0498114502605425 0.109216785394071 1.2375617949043 0.375 19.2 19 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.083751173414832 0.16529531174661 1.2375617949043 0.375 19.2 19 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.083751173414832 0.16529531174661 1.2375617949043 0.375 19.2 19 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.14628788883985 0.249534855448511 1.2375617949043 0.375 19.2 19 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.14628788883985 0.249534855448511 1.2375617949043 0.375 19.2 19 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.00110244018309374 0.00405367540191833 1.23339492017398 0.373737373737374 19.2 19 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0107156823806544 0.0303753307324129 1.23056992035682 0.372881355932203 19.2 19 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0277415689652223 0.066908902775443 1.22796829261822 0.372093023255814 19.2 19 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0758298261916015 0.153493375064934 1.22228325422647 0.37037037037037 19.2 19 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0254021188528009 0.0618959163142733 1.21962611671728 0.369565217391304 19.2 19 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.130647015346472 0.234735735906603 1.21585018446738 0.368421052631579 19.2 19 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0686840137781431 0.140629282886759 1.2100604216842 0.366666666666667 19.2 19 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0686840137781431 0.140629282886759 1.2100604216842 0.366666666666667 19.2 19 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.44890001466839e-11 4.20772392014922e-10 1.20737736088224 0.365853658536585 19.2 19 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0377633054471204 0.0869533716039683 1.20737736088224 0.365853658536585 19.2 19 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.42529632463844e-10 3.49689081027671e-09 1.20611403628939 0.365470852017937 19.2 19 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.116958907678756 0.212829316658401 1.20005992233144 0.363636363636364 19.2 19 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0622432653934829 0.128179691251702 1.20005992233144 0.363636363636364 19.2 19 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.20759872526746e-12 5.92556202088139e-11 1.19638198036282 0.362521891418564 19.2 19 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 8.65221888779733e-21 1.53901343466695e-18 1.19255203993447 0.361361361361361 19.2 19 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.104928198557595 0.193410397082199 1.18805932310813 0.36 19.2 19 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.104928198557595 0.193410397082199 1.18805932310813 0.36 19.2 19 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.104928198557595 0.193410397082199 1.18805932310813 0.36 19.2 19 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.104928198557595 0.193410397082199 1.18805932310813 0.36 19.2 19 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.209141464619105 0.329577302495002 1.17863028086124 0.357142857142857 19.2 19 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.209141464619105 0.329577302495002 1.17863028086124 0.357142857142857 19.2 19 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.209141464619105 0.329577302495002 1.17863028086124 0.357142857142857 19.2 19 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.209141464619105 0.329577302495002 1.17863028086124 0.357142857142857 19.2 19 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.0464832075405676 0.102870302224304 1.17863028086124 0.357142857142857 19.2 19 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0849096693842015 0.16619300583167 1.1710262145331 0.354838709677419 19.2 19 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0849096693842015 0.16619300583167 1.1710262145331 0.354838709677419 19.2 19 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.076556854791921 0.154306521768985 1.16476404226287 0.352941176470588 19.2 19 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.076556854791921 0.154306521768985 1.16476404226287 0.352941176470588 19.2 19 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.076556854791921 0.154306521768985 1.16476404226287 0.352941176470588 19.2 19 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.18386519588384 0.299630377687283 1.16476404226287 0.352941176470588 19.2 19 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.18386519588384 0.299630377687283 1.16476404226287 0.352941176470588 19.2 19 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.18386519588384 0.299630377687283 1.16476404226287 0.352941176470588 19.2 19 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00362526530514733 0.0113879746782001 1.16291521044975 0.352380952380952 19.2 19 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0624704644128852 0.128461663091814 1.15505767524401 0.35 19.2 19 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.162615209046335 0.273974753899067 1.15505767524401 0.35 19.2 19 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.162615209046335 0.273974753899067 1.15505767524401 0.35 19.2 19 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.0012900415174346 0.0045438838596768 1.14686577683802 0.347517730496454 19.2 19 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0420930391326483 0.0937377068634719 1.14236473375781 0.346153846153846 19.2 19 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0420930391326483 0.0937377068634719 1.14236473375781 0.346153846153846 19.2 19 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0420930391326483 0.0937377068634719 1.14236473375781 0.346153846153846 19.2 19 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.128831602665887 0.231766587349629 1.14236473375781 0.346153846153846 19.2 19 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.038212164912833 0.0878447668351558 1.14005692621487 0.345454545454545 19.2 19 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.103294450829928 0.191390629597639 1.13443164532894 0.34375 19.2 19 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0927980695079889 0.173296132427649 1.13148506962679 0.342857142857143 19.2 19 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0927980695079889 0.173296132427649 1.13148506962679 0.342857142857143 19.2 19 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0179831032213985 0.0460251005108814 1.12790442067227 0.341772151898734 19.2 19 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0555553174476305 0.117992860788027 1.1220560273799 0.34 19.2 19 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 3.61133579016388e-08 4.50783406088001e-07 1.12005592750934 0.339393939393939 19.2 19 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0375468986227243 0.086595197309784 1.11779775023614 0.338709677419355 19.2 19 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.000319966158872003 0.00136730283505964 1.1157699992153 0.338095238095238 19.2 19 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.94840403704396e-10 1.35446286913884e-08 1.11374145979982 0.337480559875583 19.2 19 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00015309058877997 0.000726159692779657 1.10005492880382 0.333333333333333 19.2 19 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0172414481415512 0.0444467041764989 1.10005492880382 0.333333333333333 19.2 19 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0896807720446387 0.171066673752709 1.10005492880382 0.333333333333333 19.2 19 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.155332490903029 0.2634542724136 1.10005492880382 0.333333333333333 19.2 19 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.155332490903029 0.2634542724136 1.10005492880382 0.333333333333333 19.2 19 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.155332490903029 0.2634542724136 1.10005492880382 0.333333333333333 19.2 19 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.155332490903029 0.2634542724136 1.10005492880382 0.333333333333333 19.2 19 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.19766696595904 0.319273657843036 1.10005492880382 0.333333333333333 19.2 19 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.224723281369428 0.352166298158672 1.10005492880382 0.333333333333333 19.2 19 2 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.224723281369428 0.352166298158672 1.10005492880382 0.333333333333333 19.2 19 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.224723281369428 0.352166298158672 1.10005492880382 0.333333333333333 19.2 19 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.12382004354815 0.223598885747484 1.10005492880382 0.333333333333333 19.2 19 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.17484382058393 0.289979902903185 1.10005492880382 0.333333333333333 19.2 19 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.17484382058393 0.289979902903185 1.10005492880382 0.333333333333333 19.2 19 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.17484382058393 0.289979902903185 1.10005492880382 0.333333333333333 19.2 19 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.257398085121274 0.382335569026695 1.10005492880382 0.333333333333333 19.2 19 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.257398085121274 0.382335569026695 1.10005492880382 0.333333333333333 19.2 19 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.257398085121274 0.382335569026695 1.10005492880382 0.333333333333333 19.2 19 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.257398085121274 0.382335569026695 1.10005492880382 0.333333333333333 19.2 19 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0074106815553798 0.0219239082189302 1.09139307897072 0.330708661417323 19.2 19 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00114161693646949 0.00416543820665663 1.08888685846063 0.32994923857868 19.2 19 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0201272668553804 0.0504244731253633 1.08835221679527 0.329787234042553 19.2 19 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.000258271923223574 0.00113432390971341 1.08711310611201 0.329411764705882 19.2 19 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0428002007308896 0.0950151102028953 1.08433985839234 0.328571428571429 19.2 19 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.057351045465369 0.120015496613559 1.08202124144638 0.327868852459016 19.2 19 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0774464436588761 0.155220125812085 1.07890002632682 0.326923076923077 19.2 19 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.1310718044323 0.23520198954245 1.07032371451182 0.324324324324324 19.2 19 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.146424177301129 0.249534855448511 1.0677003720743 0.323529411764706 19.2 19 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.163995263690585 0.273974753899067 1.06456928593918 0.32258064516129 19.2 19 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00111156332798724 0.00406875154242329 1.06228480249296 0.321888412017167 19.2 19 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.184237063191176 0.299630377687283 1.06076725277511 0.321428571428571 19.2 19 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.184237063191176 0.299630377687283 1.06076725277511 0.321428571428571 19.2 19 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0432011913572488 0.0957559116843692 1.05931215366294 0.320987654320988 19.2 19 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.207745289772794 0.329577302495002 1.05605273165167 0.32 19.2 19 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.207745289772794 0.329577302495002 1.05605273165167 0.32 19.2 19 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0311095564833897 0.0739046725807406 1.05469183895624 0.319587628865979 19.2 19 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.110966813114931 0.203224935730433 1.05324408076961 0.319148936170213 19.2 19 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.23533072648984 0.355494292776053 1.05005243204001 0.318181818181818 19.2 19 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.23533072648984 0.355494292776053 1.05005243204001 0.318181818181818 19.2 19 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0729208717928005 0.14802624901734 1.03719464715789 0.314285714285714 19.2 19 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0886910719108278 0.169405899770615 1.03130149575358 0.3125 19.2 19 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.128257674606473 0.231026165778495 1.03130149575358 0.3125 19.2 19 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.307902719794649 0.447087316599782 1.03130149575358 0.3125 19.2 19 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.307902719794649 0.447087316599782 1.03130149575358 0.3125 19.2 19 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.307902719794649 0.447087316599782 1.03130149575358 0.3125 19.2 19 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.307902719794649 0.447087316599782 1.03130149575358 0.3125 19.2 19 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0979287561528794 0.182398717284748 1.02792017937406 0.311475409836066 19.2 19 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.108224876862341 0.198714838419498 1.02418907164494 0.310344827586207 19.2 19 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.108224876862341 0.198714838419498 1.02418907164494 0.310344827586207 19.2 19 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.108224876862341 0.198714838419498 1.02418907164494 0.310344827586207 19.2 19 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.158541855216577 0.268577452349035 1.0214795767464 0.30952380952381 19.2 19 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.119720336971553 0.21757604024332 1.02005093398172 0.309090909090909 19.2 19 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.176729550974496 0.292766182813397 1.01543531889583 0.307692307692308 19.2 19 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.242818039598086 0.362570902778673 1.01543531889583 0.307692307692308 19.2 19 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.242818039598086 0.362570902778673 1.01543531889583 0.307692307692308 19.2 19 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.242818039598086 0.362570902778673 1.01543531889583 0.307692307692308 19.2 19 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.06678752866814 0.137140913845257 1.01255055946715 0.306818181818182 19.2 19 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.114798693211081 0.20916586483914 1.0000499352762 0.303030303030303 19.2 19 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0971971711139252 0.181273361068303 0.998734080098205 0.302631578947368 19.2 19 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.313369333918637 0.454561225449766 0.990049435923438 0.3 19.2 19 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0325266669384294 0.0766315348565977 0.983900060545031 0.298136645962733 19.2 19 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0360588417249986 0.0845761438865335 0.977826603381173 0.296296296296296 19.2 19 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.039879013986613 0.0905069169106066 0.971827667164111 0.294478527607362 19.2 19 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.359585021424153 0.502733153250317 0.970636701885723 0.294117647058824 19.2 19 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.359585021424153 0.502733153250317 0.970636701885723 0.294117647058824 19.2 19 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.359585021424153 0.502733153250317 0.970636701885723 0.294117647058824 19.2 19 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.359585021424153 0.502733153250317 0.970636701885723 0.294117647058824 19.2 19 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.359585021424153 0.502733153250317 0.970636701885723 0.294117647058824 19.2 19 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.359585021424153 0.502733153250317 0.970636701885723 0.294117647058824 19.2 19 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.359585021424153 0.502733153250317 0.970636701885723 0.294117647058824 19.2 19 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0583461484030957 0.12191860378503 0.966476830306213 0.292857142857143 19.2 19 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.208857693520191 0.329577302495002 0.962548062703342 0.291666666666667 19.2 19 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.316351027574856 0.458419055233218 0.962548062703342 0.291666666666667 19.2 19 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.191289990109708 0.309324609006949 0.960047937865152 0.290909090909091 19.2 19 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.108623688929411 0.199190089364113 0.957047788059323 0.29 19.2 19 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.100937854823252 0.187757604462074 0.956122508212666 0.289719626168224 19.2 19 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.255002855855883 0.380365895055473 0.95531085922437 0.289473684210526 19.2 19 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.359650281102475 0.502733153250317 0.942904224688988 0.285714285714286 19.2 19 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.142353940198759 0.24423668151495 0.937941570874836 0.284210526315789 19.2 19 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.166776943857403 0.27789647670853 0.937083828240291 0.283950617283951 19.2 19 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0799079226108569 0.159928233298522 0.936820971626479 0.283870967741935 19.2 19 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0805637387174683 0.16078849957217 0.934008901814564 0.283018867924528 19.2 19 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0805637387174683 0.16078849957217 0.934008901814564 0.283018867924528 19.2 19 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.237117885638831 0.35781415828638 0.919718055229423 0.278688524590164 19.2 19 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.184873838095175 0.299630377687283 0.91671244066985 0.277777777777778 19.2 19 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.411454921445202 0.558150956355121 0.91671244066985 0.277777777777778 19.2 19 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.411454921445202 0.558150956355121 0.91671244066985 0.277777777777778 19.2 19 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.127441959000712 0.229847791708508 0.915374174333106 0.277372262773723 19.2 19 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.237981997052359 0.358737692590579 0.908741028142286 0.27536231884058 19.2 19 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.285804834050754 0.42101478142259 0.90004494174858 0.272727272727273 19.2 19 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.354782883368465 0.501844973194161 0.90004494174858 0.272727272727273 19.2 19 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 9.064144435285e-06 5.53574142978994e-05 0.898288756496387 0.27219512195122 19.2 19 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.160612840195444 0.271762273006084 0.897838949244294 0.272058823529412 19.2 19 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.185337962068913 0.30004086464626 0.883142689321376 0.267605633802817 19.2 19 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.396391552081247 0.55300507707021 0.880043943043056 0.266666666666667 19.2 19 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.279848542079949 0.412667850134474 0.877258993856211 0.265822784810127 19.2 19 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.344790081809511 0.491619525465865 0.875553922925489 0.26530612244898 19.2 19 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.344790081809511 0.491619525465865 0.875553922925489 0.26530612244898 19.2 19 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.169126548988861 0.281481963989648 0.874097700184657 0.264864864864865 19.2 19 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.227866553084144 0.352166298158672 0.86719658621031 0.262773722627737 19.2 19 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.378785674410182 0.528961741595377 0.860912552976902 0.260869565217391 19.2 19 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.452573180627994 0.597413391496879 0.860912552976902 0.260869565217391 19.2 19 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.452573180627994 0.597413391496879 0.860912552976902 0.260869565217391 19.2 19 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.29029608258177 0.426747237101094 0.85677355031836 0.259615384615385 19.2 19 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.435947126914301 0.57707233637121 0.851655428751344 0.258064516129032 19.2 19 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.435947126914301 0.57707233637121 0.851655428751344 0.258064516129032 19.2 19 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.442153845299344 0.584744351171902 0.825041196602865 0.25 19.2 19 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.512393843472272 0.65925537003711 0.825041196602865 0.25 19.2 19 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.512393843472272 0.65925537003711 0.825041196602865 0.25 19.2 19 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.512393843472272 0.65925537003711 0.825041196602865 0.25 19.2 19 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.482352599081012 0.633783701285577 0.806706947789468 0.244444444444444 19.2 19 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.491755057282428 0.6390570287789 0.804918240588161 0.24390243902439 19.2 19 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.541999714253793 0.689479897967401 0.79203954873875 0.24 19.2 19 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.541999714253793 0.689479897967401 0.79203954873875 0.24 19.2 19 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.466783738090084 0.615600796387571 0.784795284573457 0.23780487804878 19.2 19 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.566487549720365 0.708981339711592 0.770038450162674 0.233333333333333 19.2 19 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.558973191215031 0.700192650615308 0.767480182886386 0.232558139534884 19.2 19 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.541164806206277 0.689479897967401 0.76670495037842 0.232323232323232 19.2 19 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.584228179235502 0.728183838720663 0.761576489171875 0.230769230769231 19.2 19 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.587464380602027 0.728183838720663 0.754323379751191 0.228571428571429 19.2 19 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.624352630220077 0.772568515481018 0.73336995253588 0.222222222222222 19.2 19 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.647823781450523 0.792887974520949 0.717427127480752 0.217391304347826 19.2 19 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.662144298071677 0.799856821864173 0.707178168516741 0.214285714285714 19.2 19 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.68675964186364 0.824691114237941 0.69477153398136 0.210526315789474 19.2 19 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.70711805295876 0.847707657422338 0.679445691320006 0.205882352941176 19.2 19 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.70711805295876 0.847707657422338 0.679445691320006 0.205882352941176 19.2 19 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.740972868020881 0.869970619796794 0.672255789824557 0.203703703703704 19.2 19 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.762297840326641 0.890797151598761 0.669598652315369 0.202898550724638 19.2 19 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.775011934798491 0.90248934796911 0.668387804842827 0.20253164556962 19.2 19 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.723570329983745 0.860903494621128 0.660032957282292 0.2 19.2 19 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.730192989877038 0.86225627538641 0.660032957282292 0.2 19.2 19 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.750590315126851 0.880535876690445 0.660032957282292 0.2 19.2 19 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.872171412915671 0.989712855326156 0.604255524272521 0.183098591549296 19.2 19 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.958269723553661 1 0.603255928698869 0.182795698924731 19.2 19 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.813025182571955 0.934519252665502 0.60002996116572 0.181818181818182 19.2 19 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.813025182571955 0.934519252665502 0.60002996116572 0.181818181818182 19.2 19 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.856137794338956 0.973848186526246 0.565742534813393 0.171428571428571 19.2 19 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.996203387946832 1 0.53228464296959 0.161290322580645 19.2 19 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999947418055065 1 0.510334760785277 0.154639175257732 19.2 19 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.910581676639165 1 0.5000249676381 0.151515151515152 19.2 19 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.454430751445407 0.137699412258606 19.2 19 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999998307608087 1 0.412520598301432 0.125 19.2 19 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.998966685129708 1 0.397242057623602 0.12037037037037 19.2 19 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.370000391966565 0.112115732368897 19.2 19 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999993193220183 1 0.356267789442146 0.107954545454545 19.2 19 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.99184427228425 1 0.351081360256538 0.106382978723404 19.2 19 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.993224282465796 1 0.343767165251194 0.104166666666667 19.2 19 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999894652621735 1 0.293347981014352 0.0888888888888889 19.2 19 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 5.056776179491e-07 3.91075679533461e-06 2.3458920998126 1 19.4 19 4 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 1.89806494994589e-05 0.000110694525564467 2.3458920998126 1 19.4 19 4 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00238308736549397 0.0077778287181145 2.3458920998126 1 19.4 19 4 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00238308736549397 0.0077778287181145 2.3458920998126 1 19.4 19 4 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00238308736549397 0.0077778287181145 2.3458920998126 1 19.4 19 4 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00238308736549397 0.0077778287181145 2.3458920998126 1 19.4 19 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 1.47563199673796e-05 8.89756072609373e-05 2.15040109149489 0.916666666666667 19.4 19 4 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000138782882585164 0.000639119876759508 2.11130288983134 0.9 19.4 19 4 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00042003609665193 0.00169323333012945 2.08523742205565 0.888888888888889 19.4 19 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.05850941312025e-09 8.44055369316816e-08 2.05265558733603 0.875 19.4 19 4 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00125687451881926 0.0044270604957421 2.05265558733603 0.875 19.4 19 4 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00125687451881926 0.0044270604957421 2.05265558733603 0.875 19.4 19 4 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00125687451881926 0.0044270604957421 2.05265558733603 0.875 19.4 19 4 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00125687451881926 0.0044270604957421 2.05265558733603 0.875 19.4 19 4 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 8.28816441488414e-06 5.24180353883561e-05 2.03310648650426 0.866666666666667 19.4 19 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 8.28816441488414e-06 5.24180353883561e-05 2.03310648650426 0.866666666666667 19.4 19 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.76007188016539e-07 1.75145614368906e-06 2.01076465698223 0.857142857142857 19.4 19 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.76007188016539e-07 1.75145614368906e-06 2.01076465698223 0.857142857142857 19.4 19 4 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00370772179360944 0.0114448765993628 2.01076465698223 0.857142857142857 19.4 19 4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00370772179360944 0.0114448765993628 2.01076465698223 0.857142857142857 19.4 19 4 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00370772179360944 0.0114448765993628 2.01076465698223 0.857142857142857 19.4 19 4 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00370772179360944 0.0114448765993628 2.01076465698223 0.857142857142857 19.4 19 4 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 6.97266852367149e-05 0.000353099904241442 1.98498562291836 0.846153846153846 19.4 19 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000198797689008125 0.000878537613225345 1.95491008317717 0.833333333333333 19.4 19 4 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0107385419762245 0.0276828717974049 1.95491008317717 0.833333333333333 19.4 19 4 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0107385419762245 0.0276828717974049 1.95491008317717 0.833333333333333 19.4 19 4 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.0107385419762245 0.0276828717974049 1.95491008317717 0.833333333333333 19.4 19 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000558871387584633 0.00217287973916102 1.91936626348304 0.818181818181818 19.4 19 4 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 3.19955603826419e-05 0.000177158297371593 1.90603733109774 0.8125 19.4 19 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.63538563572121e-10 8.2451921995391e-09 1.88974641373793 0.805555555555556 19.4 19 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.1971489325499e-07 2.93518898775388e-06 1.87671367985008 0.8 19.4 19 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.1971489325499e-07 2.93518898775388e-06 1.87671367985008 0.8 19.4 19 4 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00154504895291899 0.00531063927537132 1.87671367985008 0.8 19.4 19 4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00154504895291899 0.00531063927537132 1.87671367985008 0.8 19.4 19 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00154504895291899 0.00531063927537132 1.87671367985008 0.8 19.4 19 4 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00154504895291899 0.00531063927537132 1.87671367985008 0.8 19.4 19 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000236788332525283 0.0010272859670228 1.84320093556705 0.785714285714286 19.4 19 4 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000236788332525283 0.0010272859670228 1.84320093556705 0.785714285714286 19.4 19 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 3.7505118108929e-05 0.000202926931821315 1.82458274429869 0.777777777777778 19.4 19 4 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.00418580899640493 0.0123066243840583 1.82458274429869 0.777777777777778 19.4 19 4 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00418580899640493 0.0123066243840583 1.82458274429869 0.777777777777778 19.4 19 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00418580899640493 0.0123066243840583 1.82458274429869 0.777777777777778 19.4 19 4 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00418580899640493 0.0123066243840583 1.82458274429869 0.777777777777778 19.4 19 4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000629034368246155 0.00242771924069729 1.80453238447123 0.769230769230769 19.4 19 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.64422340582993e-07 1.65938291240851e-06 1.798517276523 0.766666666666667 19.4 19 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 9.85060347137977e-05 0.000473561106073426 1.79391748809199 0.764705882352941 19.4 19 4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 9.85060347137977e-05 0.000473561106073426 1.79391748809199 0.764705882352941 19.4 19 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.57658726034987e-06 1.80614959186102e-05 1.78287799585758 0.76 19.4 19 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000254691044101497 0.00108888475789413 1.75941907485945 0.75 19.4 19 4 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00163909248331416 0.00552708199942191 1.75941907485945 0.75 19.4 19 4 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00163909248331416 0.00552708199942191 1.75941907485945 0.75 19.4 19 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00163909248331416 0.00552708199942191 1.75941907485945 0.75 19.4 19 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00163909248331416 0.00552708199942191 1.75941907485945 0.75 19.4 19 4 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.01106026361798 0.0282056543519453 1.75941907485945 0.75 19.4 19 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.01106026361798 0.0282056543519453 1.75941907485945 0.75 19.4 19 4 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.01106026361798 0.0282056543519453 1.75941907485945 0.75 19.4 19 4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.01106026361798 0.0282056543519453 1.75941907485945 0.75 19.4 19 4 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.01106026361798 0.0282056543519453 1.75941907485945 0.75 19.4 19 4 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.01106026361798 0.0282056543519453 1.75941907485945 0.75 19.4 19 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.17063720848132e-12 1.60400452639701e-10 1.75941907485945 0.75 19.4 19 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.67288986164372e-05 9.91884280466254e-05 1.73392024768758 0.739130434782609 19.4 19 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000103089469360839 0.000488331145237461 1.72855207354613 0.736842105263158 19.4 19 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000103089469360839 0.000488331145237461 1.72855207354613 0.736842105263158 19.4 19 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000646865310860834 0.00247443370256711 1.72032087319591 0.733333333333333 19.4 19 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000646865310860834 0.00247443370256711 1.72032087319591 0.733333333333333 19.4 19 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000646865310860834 0.00247443370256711 1.72032087319591 0.733333333333333 19.4 19 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 6.87362591014503e-06 4.50745146089234e-05 1.71430576524767 0.730769230769231 19.4 19 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 9.5788561074526e-10 1.45007577030905e-08 1.71054632278002 0.729166666666667 19.4 19 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 4.17847831857142e-05 0.000219408658572957 1.70610334531826 0.727272727272727 19.4 19 4 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00417485579381061 0.0123066243840583 1.70610334531826 0.727272727272727 19.4 19 4 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00417485579381061 0.0123066243840583 1.70610334531826 0.727272727272727 19.4 19 4 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00417485579381061 0.0123066243840583 1.70610334531826 0.727272727272727 19.4 19 4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000257108417886457 0.00108888475789413 1.69425540542021 0.722222222222222 19.4 19 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000257108417886457 0.00108888475789413 1.69425540542021 0.722222222222222 19.4 19 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000257108417886457 0.00108888475789413 1.69425540542021 0.722222222222222 19.4 19 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.69689707391964e-05 9.93697339994915e-05 1.68904231186508 0.72 19.4 19 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.16013167093571e-06 8.59826754032041e-06 1.68610994674031 0.71875 19.4 19 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.73701135210853e-09 7.09892796004386e-08 1.68292259334383 0.717391304347826 19.4 19 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00160964945754834 0.00547973966050547 1.67563721415186 0.714285714285714 19.4 19 4 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00160964945754834 0.00547973966050547 1.67563721415186 0.714285714285714 19.4 19 4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00160964945754834 0.00547973966050547 1.67563721415186 0.714285714285714 19.4 19 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00160964945754834 0.00547973966050547 1.67563721415186 0.714285714285714 19.4 19 4 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0283155924327623 0.0623732012876483 1.67563721415186 0.714285714285714 19.4 19 4 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0283155924327623 0.0623732012876483 1.67563721415186 0.714285714285714 19.4 19 4 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0283155924327623 0.0623732012876483 1.67563721415186 0.714285714285714 19.4 19 4 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0283155924327623 0.0623732012876483 1.67563721415186 0.714285714285714 19.4 19 4 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0283155924327623 0.0623732012876483 1.67563721415186 0.714285714285714 19.4 19 4 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0283155924327623 0.0623732012876483 1.67563721415186 0.714285714285714 19.4 19 4 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0283155924327623 0.0623732012876483 1.67563721415186 0.714285714285714 19.4 19 4 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0283155924327623 0.0623732012876483 1.67563721415186 0.714285714285714 19.4 19 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000102805910204688 0.000488331145237461 1.67563721415186 0.714285714285714 19.4 19 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000102805910204688 0.000488331145237461 1.67563721415186 0.714285714285714 19.4 19 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.38737386487355e-08 1.61822377845497e-07 1.66818993764452 0.711111111111111 19.4 19 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 4.1311976858462e-05 0.000217729418776265 1.6616735707006 0.708333333333333 19.4 19 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 4.1311976858462e-05 0.000217729418776265 1.6616735707006 0.708333333333333 19.4 19 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.37693797474419e-09 3.38238273806098e-08 1.65592383516184 0.705882352941177 19.4 19 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.37693797474419e-09 3.38238273806098e-08 1.65592383516184 0.705882352941177 19.4 19 4 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.000629535066631974 0.00242771924069729 1.65592383516184 0.705882352941177 19.4 19 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.32670770179869e-08 3.69836332785901e-07 1.65278761577706 0.704545454545455 19.4 19 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.66697407634753e-05 9.91884280466254e-05 1.65081295912739 0.703703703703704 19.4 19 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.37129913985828e-08 1.61269312067631e-07 1.64711572965566 0.702127659574468 19.4 19 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 6.74976366361619e-06 4.44671930246567e-05 1.64212446986882 0.7 19.4 19 4 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000248752948604991 0.00107265286625728 1.64212446986882 0.7 19.4 19 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000248752948604991 0.00107265286625728 1.64212446986882 0.7 19.4 19 4 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0103475824312054 0.0268697259116886 1.64212446986882 0.7 19.4 19 4 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0103475824312054 0.0268697259116886 1.64212446986882 0.7 19.4 19 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 6.31100242826129e-14 2.99351881847194e-12 1.62832510457581 0.694117647058824 19.4 19 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 6.31100242826129e-14 2.99351881847194e-12 1.62832510457581 0.694117647058824 19.4 19 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 6.31100242826129e-14 2.99351881847194e-12 1.62832510457581 0.694117647058824 19.4 19 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 3.96834966045618e-05 0.000211496687896222 1.62407914602411 0.692307692307692 19.4 19 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00391172324221716 0.0118182211755308 1.62407914602411 0.692307692307692 19.4 19 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.59750226118897e-05 9.59175408300381e-05 1.61785662056042 0.689655172413793 19.4 19 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.05547309807133e-14 6.25807591064791e-13 1.61437735901082 0.688172043010753 19.4 19 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00150964869773138 0.00523958560212622 1.61280081862117 0.6875 19.4 19 4 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00150964869773138 0.00523958560212622 1.61280081862117 0.6875 19.4 19 4 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00150964869773138 0.00523958560212622 1.61280081862117 0.6875 19.4 19 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 6.56361579928932e-11 1.41515534581647e-09 1.6106124864385 0.686567164179104 19.4 19 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 8.93554960192681e-10 1.36723517027332e-08 1.60302626820528 0.683333333333333 19.4 19 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 8.93554960192681e-10 1.36723517027332e-08 1.60302626820528 0.683333333333333 19.4 19 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 8.93554960192681e-10 1.36723517027332e-08 1.60302626820528 0.683333333333333 19.4 19 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 8.93554960192681e-10 1.36723517027332e-08 1.60302626820528 0.683333333333333 19.4 19 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 8.93554960192681e-10 1.36723517027332e-08 1.60302626820528 0.683333333333333 19.4 19 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 8.93554960192681e-10 1.36723517027332e-08 1.60302626820528 0.683333333333333 19.4 19 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 8.93554960192681e-10 1.36723517027332e-08 1.60302626820528 0.683333333333333 19.4 19 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.33856420035239e-07 3.81097336858114e-06 1.60207265353056 0.682926829268293 19.4 19 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.33856420035239e-07 3.81097336858114e-06 1.60207265353056 0.682926829268293 19.4 19 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.68283311756677e-10 6.89562042933884e-09 1.60116444907844 0.682539682539683 19.4 19 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 6.26936265113152e-11 1.39395360196252e-09 1.5979265027709 0.681159420289855 19.4 19 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.06979464161493e-11 3.30938646743052e-10 1.59520662787257 0.68 19.4 19 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.06979464161493e-11 3.30938646743052e-10 1.59520662787257 0.68 19.4 19 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.06979464161493e-11 3.30938646743052e-10 1.59520662787257 0.68 19.4 19 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.06979464161493e-11 3.30938646743052e-10 1.59520662787257 0.68 19.4 19 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.06979464161493e-11 3.30938646743052e-10 1.59520662787257 0.68 19.4 19 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 3.72841511420606e-05 0.000202501324714321 1.59185535344427 0.678571428571429 19.4 19 4 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 3.72841511420606e-05 0.000202501324714321 1.59185535344427 0.678571428571429 19.4 19 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.05896087450465e-09 2.98969522900012e-08 1.59043532190685 0.677966101694915 19.4 19 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.05896087450465e-09 2.98969522900012e-08 1.59043532190685 0.677966101694915 19.4 19 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 2.46093591819203e-06 1.74224468238172e-05 1.58506222960311 0.675675675675676 19.4 19 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.70816183360349e-09 6.03577863893492e-08 1.57741020504641 0.672413793103448 19.4 19 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.70816183360349e-09 6.03577863893492e-08 1.57741020504641 0.672413793103448 19.4 19 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.49341859829274e-22 5.81284969579143e-20 1.56881534174968 0.66875 19.4 19 4 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000214542175743833 0.00093936466487223 1.56392806654174 0.666666666666667 19.4 19 4 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000214542175743833 0.00093936466487223 1.56392806654174 0.666666666666667 19.4 19 4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00924638241480353 0.0241423893142485 1.56392806654174 0.666666666666667 19.4 19 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00924638241480353 0.0241423893142485 1.56392806654174 0.666666666666667 19.4 19 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00924638241480353 0.0241423893142485 1.56392806654174 0.666666666666667 19.4 19 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00924638241480353 0.0241423893142485 1.56392806654174 0.666666666666667 19.4 19 4 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00924638241480353 0.0241423893142485 1.56392806654174 0.666666666666667 19.4 19 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 8.57110082867347e-05 0.000421223492005941 1.56392806654174 0.666666666666667 19.4 19 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 8.57110082867347e-05 0.000421223492005941 1.56392806654174 0.666666666666667 19.4 19 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 8.57110082867347e-05 0.000421223492005941 1.56392806654174 0.666666666666667 19.4 19 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00137438836412301 0.0048171296604607 1.56392806654174 0.666666666666667 19.4 19 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00353521775092334 0.0110079099771639 1.56392806654174 0.666666666666667 19.4 19 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00353521775092334 0.0110079099771639 1.56392806654174 0.666666666666667 19.4 19 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00353521775092334 0.0110079099771639 1.56392806654174 0.666666666666667 19.4 19 4 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0248091728611301 0.0567579629925854 1.56392806654174 0.666666666666667 19.4 19 4 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0248091728611301 0.0567579629925854 1.56392806654174 0.666666666666667 19.4 19 4 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0248091728611301 0.0567579629925854 1.56392806654174 0.666666666666667 19.4 19 4 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0248091728611301 0.0567579629925854 1.56392806654174 0.666666666666667 19.4 19 4 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0248091728611301 0.0567579629925854 1.56392806654174 0.666666666666667 19.4 19 4 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0248091728611301 0.0567579629925854 1.56392806654174 0.666666666666667 19.4 19 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.72199578318595e-14 9.4246153825908e-13 1.55640918160644 0.663461538461538 19.4 19 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.09402842730717e-06 1.49738816686337e-05 1.54485577304732 0.658536585365854 19.4 19 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.09402842730717e-06 1.49738816686337e-05 1.54485577304732 0.658536585365854 19.4 19 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 3.73235910316182e-09 5.10687211903776e-08 1.53949169050202 0.65625 19.4 19 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 7.77714953493858e-05 0.00038967900662738 1.5369637895324 0.655172413793103 19.4 19 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 7.77714953493858e-05 0.00038967900662738 1.5369637895324 0.655172413793103 19.4 19 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 4.10204125262764e-11 1.16744094049783e-09 1.53496643567985 0.654320987654321 19.4 19 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 4.10204125262764e-11 1.16744094049783e-09 1.53496643567985 0.654320987654321 19.4 19 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.000193827004903544 0.000859239339494526 1.53385252680055 0.653846153846154 19.4 19 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000193827004903544 0.000859239339494526 1.53385252680055 0.653846153846154 19.4 19 4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000485771889881687 0.00191482936094637 1.52992963031257 0.652173913043478 19.4 19 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 9.05204723708259e-11 1.92254674901023e-09 1.52482986487819 0.65 19.4 19 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00122607635171063 0.00436176662121057 1.52482986487819 0.65 19.4 19 4 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00122607635171063 0.00436176662121057 1.52482986487819 0.65 19.4 19 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00122607635171063 0.00436176662121057 1.52482986487819 0.65 19.4 19 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.40798486404949e-11 1.01032551282134e-09 1.51793018223169 0.647058823529412 19.4 19 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.8833043324546e-07 2.71718017555159e-06 1.51793018223169 0.647058823529412 19.4 19 4 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00312319035474695 0.00992031222054668 1.51793018223169 0.647058823529412 19.4 19 4 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00312319035474695 0.00992031222054668 1.51793018223169 0.647058823529412 19.4 19 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00312319035474695 0.00992031222054668 1.51793018223169 0.647058823529412 19.4 19 4 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00312319035474695 0.00992031222054668 1.51793018223169 0.647058823529412 19.4 19 4 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00312319035474695 0.00992031222054668 1.51793018223169 0.647058823529412 19.4 19 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.98463772975139e-10 3.86868423210443e-09 1.51443667203092 0.645569620253165 19.4 19 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.98463772975139e-10 3.86868423210443e-09 1.51443667203092 0.645569620253165 19.4 19 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.98463772975139e-10 3.86868423210443e-09 1.51443667203092 0.645569620253165 19.4 19 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.81569218295936e-08 2.08365320673481e-07 1.51347877407265 0.645161290322581 19.4 19 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000172879351147148 0.000785965867994863 1.50807349273667 0.642857142857143 19.4 19 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00805545605462105 0.0217926121021402 1.50807349273667 0.642857142857143 19.4 19 4 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00805545605462105 0.0217926121021402 1.50807349273667 0.642857142857143 19.4 19 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.04768471962242e-25 1.22940790800324e-22 1.50807349273667 0.642857142857143 19.4 19 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 6.759117835817e-09 8.22070485501503e-08 1.50557254167078 0.641791044776119 19.4 19 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 6.759117835817e-09 8.22070485501503e-08 1.50557254167078 0.641791044776119 19.4 19 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.04235013297937e-09 1.56133077813647e-08 1.50137094388007 0.64 19.4 19 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 6.30503638974626e-07 4.82369181860695e-06 1.50137094388007 0.64 19.4 19 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 2.51713865451355e-05 0.000143275532214911 1.4987643971025 0.638888888888889 19.4 19 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.51713865451355e-05 0.000143275532214911 1.4987643971025 0.638888888888889 19.4 19 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 2.51713865451355e-05 0.000143275532214911 1.4987643971025 0.638888888888889 19.4 19 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00107803975068603 0.0038641072171945 1.49284042715348 0.636363636363636 19.4 19 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00107803975068603 0.0038641072171945 1.49284042715348 0.636363636363636 19.4 19 4 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0211498540466464 0.0495003985335162 1.49284042715348 0.636363636363636 19.4 19 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0211498540466464 0.0495003985335162 1.49284042715348 0.636363636363636 19.4 19 4 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0211498540466464 0.0495003985335162 1.49284042715348 0.636363636363636 19.4 19 4 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0211498540466464 0.0495003985335162 1.49284042715348 0.636363636363636 19.4 19 4 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0211498540466464 0.0495003985335162 1.49284042715348 0.636363636363636 19.4 19 4 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0211498540466464 0.0495003985335162 1.49284042715348 0.636363636363636 19.4 19 4 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0211498540466464 0.0495003985335162 1.49284042715348 0.636363636363636 19.4 19 4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0211498540466464 0.0495003985335162 1.49284042715348 0.636363636363636 19.4 19 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 6.19003699493294e-05 0.000315714073254106 1.49284042715348 0.636363636363636 19.4 19 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 5.38092919047767e-11 1.39395360196252e-09 1.48573166321465 0.633333333333333 19.4 19 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00271765503457623 0.00878914344136811 1.48161606303954 0.631578947368421 19.4 19 4 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00271765503457623 0.00878914344136811 1.48161606303954 0.631578947368421 19.4 19 4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00271765503457623 0.00878914344136811 1.48161606303954 0.631578947368421 19.4 19 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000377624199152122 0.00154858569277657 1.47704317395608 0.62962962962963 19.4 19 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000937821413444778 0.00339572486344 1.46618256238288 0.625 19.4 19 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00691116617290996 0.0192081825469744 1.46618256238288 0.625 19.4 19 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00691116617290996 0.0192081825469744 1.46618256238288 0.625 19.4 19 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00691116617290996 0.0192081825469744 1.46618256238288 0.625 19.4 19 4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00691116617290996 0.0192081825469744 1.46618256238288 0.625 19.4 19 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00691116617290996 0.0192081825469744 1.46618256238288 0.625 19.4 19 4 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00691116617290996 0.0192081825469744 1.46618256238288 0.625 19.4 19 4 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0570744737907329 0.113115565744029 1.46618256238288 0.625 19.4 19 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0570744737907329 0.113115565744029 1.46618256238288 0.625 19.4 19 4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0570744737907329 0.113115565744029 1.46618256238288 0.625 19.4 19 4 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0570744737907329 0.113115565744029 1.46618256238288 0.625 19.4 19 4 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0570744737907329 0.113115565744029 1.46618256238288 0.625 19.4 19 4 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0570744737907329 0.113115565744029 1.46618256238288 0.625 19.4 19 4 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.0570744737907329 0.113115565744029 1.46618256238288 0.625 19.4 19 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.95867701716888e-05 0.000113763158997196 1.46618256238288 0.625 19.4 19 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.8371430885487e-10 1.02546353271664e-08 1.46273272105962 0.623529411764706 19.4 19 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.06232347578383e-06 7.99834024359997e-06 1.46064979799653 0.622641509433962 19.4 19 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000328510387907123 0.00135498632461402 1.45607095850438 0.620689655172414 19.4 19 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.000116305280546708 0.000540857562803809 1.44893335576661 0.617647058823529 19.4 19 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 6.17847770665607e-06 4.10839896101476e-05 1.44746533818225 0.617021276595745 19.4 19 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 6.17847770665607e-06 4.10839896101476e-05 1.44746533818225 0.617021276595745 19.4 19 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0177818370909417 0.0428148124880035 1.44362590757699 0.615384615384615 19.4 19 4 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0177818370909417 0.0428148124880035 1.44362590757699 0.615384615384615 19.4 19 4 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0177818370909417 0.0428148124880035 1.44362590757699 0.615384615384615 19.4 19 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 8.42900265813667e-12 2.99861769563212e-10 1.44197037327931 0.614678899082569 19.4 19 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 7.38461048783384e-12 2.69443608312501e-10 1.43712308817349 0.612612612612613 19.4 19 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.9596375224937e-08 4.36787922054925e-07 1.43360072766326 0.611111111111111 19.4 19 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00587130776858455 0.0166431692324618 1.43360072766326 0.611111111111111 19.4 19 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00587130776858455 0.0166431692324618 1.43360072766326 0.611111111111111 19.4 19 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.29143819291736e-05 7.92119201948881e-05 1.42793432162506 0.608695652173913 19.4 19 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 4.66199714319666e-06 3.15905806417564e-05 1.42593441361158 0.607843137254902 19.4 19 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.84719761853763e-13 1.22774612459971e-11 1.42558058373228 0.607692307692308 19.4 19 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.02743436298825e-09 5.25783403535071e-08 1.4184463859332 0.604651162790698 19.4 19 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 4.02743436298825e-09 5.25783403535071e-08 1.4184463859332 0.604651162790698 19.4 19 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 1.11516021474148e-05 6.95996923498738e-05 1.41730981030345 0.604166666666667 19.4 19 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 5.31458063539817e-07 4.08791796982248e-06 1.4149825363949 0.603174603174603 19.4 19 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.41323720572079e-11 1.40400562211395e-09 1.41187950451685 0.601851851851852 19.4 19 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.66509045519131e-05 0.000149898170661551 1.40753525988756 0.6 19.4 19 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.66509045519131e-05 0.000149898170661551 1.40753525988756 0.6 19.4 19 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00169873677431105 0.00570118497604864 1.40753525988756 0.6 19.4 19 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00169873677431105 0.00570118497604864 1.40753525988756 0.6 19.4 19 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 7.43813463799344e-05 0.000375335659215059 1.40753525988756 0.6 19.4 19 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00495502305887459 0.0141586301461417 1.40753525988756 0.6 19.4 19 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00495502305887459 0.0141586301461417 1.40753525988756 0.6 19.4 19 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00495502305887459 0.0141586301461417 1.40753525988756 0.6 19.4 19 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00495502305887459 0.0141586301461417 1.40753525988756 0.6 19.4 19 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00495502305887459 0.0141586301461417 1.40753525988756 0.6 19.4 19 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00495502305887459 0.0141586301461417 1.40753525988756 0.6 19.4 19 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00495502305887459 0.0141586301461417 1.40753525988756 0.6 19.4 19 4 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0148358135101676 0.0368435647905209 1.40753525988756 0.6 19.4 19 4 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0465015585060169 0.0949379020861723 1.40753525988756 0.6 19.4 19 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.66252036788289e-20 2.70626177392668e-18 1.39911950347568 0.596412556053812 19.4 19 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 8.28525874910931e-10 1.36723517027332e-08 1.39805690796913 0.595959595959596 19.4 19 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000178275854998167 0.000802805511589848 1.39485476205074 0.594594594594595 19.4 19 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000178275854998167 0.000802805511589848 1.39485476205074 0.594594594594595 19.4 19 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.27800717430055e-15 9.09302104514841e-14 1.39373589459455 0.594117647058824 19.4 19 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.13984695053269e-11 3.45106853320854e-10 1.39227742509203 0.59349593495935 19.4 19 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 7.05683357398385e-06 4.60636430081606e-05 1.39015828137043 0.592592592592593 19.4 19 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00143717368518319 0.0050248111892277 1.39015828137043 0.592592592592593 19.4 19 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.5629961429597e-15 1.65779250519621e-13 1.38810183420864 0.591715976331361 19.4 19 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00416258459934672 0.0123066243840583 1.38620896807108 0.590909090909091 19.4 19 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00416258459934672 0.0123066243840583 1.38620896807108 0.590909090909091 19.4 19 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00416258459934672 0.0123066243840583 1.38620896807108 0.590909090909091 19.4 19 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00416258459934672 0.0123066243840583 1.38620896807108 0.590909090909091 19.4 19 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 2.1908155205808e-06 1.55876524289324e-05 1.38446091136482 0.590163934426229 19.4 19 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 9.14251427427965e-08 9.49620278270069e-07 1.38347482809461 0.58974358974359 19.4 19 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.88828580266598e-09 5.17105672634925e-08 1.3828416588369 0.589473684210526 19.4 19 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.88828580266598e-09 5.17105672634925e-08 1.3828416588369 0.589473684210526 19.4 19 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.49625535622262e-07 2.43299409034575e-06 1.38182685331427 0.589041095890411 19.4 19 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000426701989570115 0.00170083173993914 1.37993652930153 0.588235294117647 19.4 19 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000426701989570115 0.00170083173993914 1.37993652930153 0.588235294117647 19.4 19 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000426701989570115 0.00170083173993914 1.37993652930153 0.588235294117647 19.4 19 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000426701989570115 0.00170083173993914 1.37993652930153 0.588235294117647 19.4 19 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0123225601988572 0.0310354038282721 1.37993652930153 0.588235294117647 19.4 19 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0123225601988572 0.0310354038282721 1.37993652930153 0.588235294117647 19.4 19 4 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0123225601988572 0.0310354038282721 1.37993652930153 0.588235294117647 19.4 19 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0123225601988572 0.0310354038282721 1.37993652930153 0.588235294117647 19.4 19 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0123225601988572 0.0310354038282721 1.37993652930153 0.588235294117647 19.4 19 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.8716213102952e-06 1.36580365361542e-05 1.3777461538582 0.587301587301587 19.4 19 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.61712261737012e-05 0.000239678158380892 1.37693666728131 0.58695652173913 19.4 19 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 4.61712261737012e-05 0.000239678158380892 1.37693666728131 0.58695652173913 19.4 19 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 4.48074956254905e-22 5.81284969579143e-20 1.37517812747635 0.586206896551724 19.4 19 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000128645886932566 0.000596296733241175 1.37320513159762 0.585365853658537 19.4 19 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00348547876982665 0.0109247495362628 1.36843705822402 0.583333333333333 19.4 19 4 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00348547876982665 0.0109247495362628 1.36843705822402 0.583333333333333 19.4 19 4 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0378147143312265 0.0794835132840994 1.36843705822402 0.583333333333333 19.4 19 4 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0378147143312265 0.0794835132840994 1.36843705822402 0.583333333333333 19.4 19 4 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0378147143312265 0.0794835132840994 1.36843705822402 0.583333333333333 19.4 19 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0378147143312265 0.0794835132840994 1.36843705822402 0.583333333333333 19.4 19 4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0378147143312265 0.0794835132840994 1.36843705822402 0.583333333333333 19.4 19 4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0378147143312265 0.0794835132840994 1.36843705822402 0.583333333333333 19.4 19 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.9741253718956e-07 3.86785814437565e-06 1.36843705822402 0.583333333333333 19.4 19 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.65265644681126e-14 2.45212226807867e-12 1.36723772688465 0.582822085889571 19.4 19 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.35940052669699e-06 1.00229375621234e-05 1.36551928198047 0.582089552238806 19.4 19 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.2044101760846e-05 7.41937524055578e-05 1.36488267625461 0.581818181818182 19.4 19 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.2044101760846e-05 7.41937524055578e-05 1.36488267625461 0.581818181818182 19.4 19 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.2044101760846e-05 7.41937524055578e-05 1.36488267625461 0.581818181818182 19.4 19 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 4.87384841726642e-08 5.29426434944284e-07 1.363890755705 0.581395348837209 19.4 19 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000108915405298961 0.000508152858165315 1.363890755705 0.581395348837209 19.4 19 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000108915405298961 0.000508152858165315 1.363890755705 0.581395348837209 19.4 19 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.48360117744828e-22 5.50796052834322e-20 1.36268732268526 0.580882352941177 19.4 19 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.32461074575023e-07 1.34637220800184e-06 1.36119665050855 0.580246913580247 19.4 19 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 4.81807493796186e-09 6.0673633953272e-08 1.36061741789131 0.58 19.4 19 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.1560926476917e-06 8.59826754032041e-06 1.35993744916673 0.579710144927536 19.4 19 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.51858763513779e-09 2.25098979666778e-08 1.3593019643774 0.579439252336449 19.4 19 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.51416851982975e-10 3.07808829102534e-09 1.35712766104861 0.578512396694215 19.4 19 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.51416851982975e-10 3.07808829102534e-09 1.35712766104861 0.578512396694215 19.4 19 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00291161531890445 0.00935266049390753 1.35339928835343 0.576923076923077 19.4 19 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00085558132985118 0.00312177495481597 1.35066514837695 0.575757575757576 19.4 19 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 8.33123958667846e-07 6.33976146087885e-06 1.34969134509766 0.575342465753425 19.4 19 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000256142881777855 0.00108888475789413 1.34888795739225 0.575 19.4 19 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000256142881777855 0.00108888475789413 1.34888795739225 0.575 19.4 19 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.37682278645479e-05 0.000137488570127039 1.34671583507761 0.574074074074074 19.4 19 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 7.32443926250716e-06 4.71614347083606e-05 1.3460036638269 0.573770491803279 19.4 19 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 7.32443926250716e-06 4.71614347083606e-05 1.3460036638269 0.573770491803279 19.4 19 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.53191232835889e-13 1.12590976351709e-11 1.34459669135601 0.573170731707317 19.4 19 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 2.20468356653984e-07 2.17865605221263e-06 1.34459669135601 0.573170731707317 19.4 19 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.83750528427314e-08 2.09181601561655e-07 1.34050977132149 0.571428571428571 19.4 19 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00242800785854769 0.00790630476593448 1.34050977132149 0.571428571428571 19.4 19 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00844185512809899 0.0225803756527911 1.34050977132149 0.571428571428571 19.4 19 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00844185512809899 0.0225803756527911 1.34050977132149 0.571428571428571 19.4 19 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00844185512809899 0.0225803756527911 1.34050977132149 0.571428571428571 19.4 19 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00844185512809899 0.0225803756527911 1.34050977132149 0.571428571428571 19.4 19 4 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0307503451393692 0.0659996095525224 1.34050977132149 0.571428571428571 19.4 19 4 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0307503451393692 0.0659996095525224 1.34050977132149 0.571428571428571 19.4 19 4 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0307503451393692 0.0659996095525224 1.34050977132149 0.571428571428571 19.4 19 4 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0307503451393692 0.0659996095525224 1.34050977132149 0.571428571428571 19.4 19 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0307503451393692 0.0659996095525224 1.34050977132149 0.571428571428571 19.4 19 4 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0307503451393692 0.0659996095525224 1.34050977132149 0.571428571428571 19.4 19 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.62892648561172e-17 2.86886799390304e-15 1.33600133038655 0.569506726457399 19.4 19 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.62283371364855e-06 1.19035689408345e-05 1.3358552235044 0.569444444444444 19.4 19 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.69164742600393e-05 9.93697339994915e-05 1.33473171196234 0.568965517241379 19.4 19 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.69164742600393e-05 9.93697339994915e-05 1.33473171196234 0.568965517241379 19.4 19 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 4.19628447978703e-08 4.59331754979765e-07 1.33345445673559 0.568421052631579 19.4 19 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.42499863086132e-05 8.62882149666236e-05 1.32933885656048 0.566666666666667 19.4 19 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.42499863086132e-05 8.62882149666236e-05 1.32933885656048 0.566666666666667 19.4 19 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.1746626230449e-21 1.39295409382741e-19 1.32907197463786 0.566552901023891 19.4 19 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.61150039054532e-07 3.27335353869171e-06 1.32839673121919 0.566265060240964 19.4 19 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 4.63186883729762e-05 0.000239678158380892 1.32786345272412 0.566037735849057 19.4 19 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.00078694437078e-08 3.36229907231466e-07 1.32696926858087 0.565656565656566 19.4 19 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00697479567297904 0.0192721053255324 1.32593901293756 0.565217391304348 19.4 19 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00697479567297904 0.0192721053255324 1.32593901293756 0.565217391304348 19.4 19 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00697479567297904 0.0192721053255324 1.32593901293756 0.565217391304348 19.4 19 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.71648739753873e-06 2.55486066024039e-05 1.32593901293756 0.565217391304348 19.4 19 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.54271070523091e-13 7.08153978562445e-12 1.32536276825571 0.564971751412429 19.4 19 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 2.12485660642615e-10 4.03156126792588e-09 1.32516042279491 0.564885496183206 19.4 19 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 2.12485660642615e-10 4.03156126792588e-09 1.32516042279491 0.564885496183206 19.4 19 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.04844976607115e-07 2.83525752752892e-06 1.32473906812947 0.564705882352941 19.4 19 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.04844976607115e-07 2.83525752752892e-06 1.32473906812947 0.564705882352941 19.4 19 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.78144772763307e-37 1.31933337214062e-34 1.32458166092081 0.564638783269962 19.4 19 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 6.7208149527578e-10 1.1385380568779e-08 1.32429392731357 0.564516129032258 19.4 19 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 6.7208149527578e-10 1.1385380568779e-08 1.32429392731357 0.564516129032258 19.4 19 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 6.7208149527578e-10 1.1385380568779e-08 1.32429392731357 0.564516129032258 19.4 19 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.89118907484963e-05 0.000208163986974098 1.32223009262165 0.563636363636364 19.4 19 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.89118907484963e-05 0.000208163986974098 1.32223009262165 0.563636363636364 19.4 19 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.89118907484963e-05 0.000208163986974098 1.32223009262165 0.563636363636364 19.4 19 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.57153772750144e-07 2.43953212415637e-06 1.32124957345767 0.563218390804598 19.4 19 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.57153772750144e-07 2.43953212415637e-06 1.32124957345767 0.563218390804598 19.4 19 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.57153772750144e-07 2.43953212415637e-06 1.32124957345767 0.563218390804598 19.4 19 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.00866060095856e-05 6.32301337076667e-05 1.31956430614459 0.5625 19.4 19 4 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0250246458009275 0.0570674214338458 1.31956430614459 0.5625 19.4 19 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0250246458009275 0.0570674214338458 1.31956430614459 0.5625 19.4 19 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.63464933721753e-06 1.83779706218654e-05 1.31755583688105 0.561643835616438 19.4 19 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 4.80772318538779e-09 6.0673633953272e-08 1.31699205603515 0.56140350877193 19.4 19 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.08418916676303e-10 2.26882527103499e-09 1.31639988334808 0.561151079136691 19.4 19 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.09947420487124e-29 3.12910358706356e-27 1.3161225630404 0.561032863849765 19.4 19 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00041905570852461 0.00169323333012945 1.31598825111439 0.560975609756098 19.4 19 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00041905570852461 0.00169323333012945 1.31598825111439 0.560975609756098 19.4 19 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00041905570852461 0.00169323333012945 1.31598825111439 0.560975609756098 19.4 19 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00041905570852461 0.00169323333012945 1.31598825111439 0.560975609756098 19.4 19 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00575951403684653 0.0163915769488652 1.31369957589506 0.56 19.4 19 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00575951403684653 0.0163915769488652 1.31369957589506 0.56 19.4 19 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 7.1198882862755e-06 4.62630184080824e-05 1.31093970283646 0.558823529411765 19.4 19 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.69273231935262e-10 1.2878538929928e-08 1.3093351254768 0.558139534883721 19.4 19 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.88811073181131e-18 2.56861348210468e-16 1.30828597874164 0.557692307692308 19.4 19 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.12159414745114e-07 3.66564279488936e-06 1.30623537375929 0.556818181818182 19.4 19 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 5.0144549126839e-06 3.38178641741668e-05 1.30327338878478 0.555555555555556 19.4 19 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00475466736105602 0.0138645320794728 1.30327338878478 0.555555555555556 19.4 19 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00475466736105602 0.0138645320794728 1.30327338878478 0.555555555555556 19.4 19 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00475466736105602 0.0138645320794728 1.30327338878478 0.555555555555556 19.4 19 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0203866257366979 0.0485119873299684 1.30327338878478 0.555555555555556 19.4 19 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0203866257366979 0.0485119873299684 1.30327338878478 0.555555555555556 19.4 19 4 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0203866257366979 0.0485119873299684 1.30327338878478 0.555555555555556 19.4 19 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0203866257366979 0.0485119873299684 1.30327338878478 0.555555555555556 19.4 19 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0974060999527366 0.168010763918478 1.30327338878478 0.555555555555556 19.4 19 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.99581325174337e-58 5.68604225723082e-55 1.30297853055202 0.555429864253394 19.4 19 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.44170227572293e-09 6.79258099855591e-08 1.30108301334144 0.554621848739496 19.4 19 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.61193466646531e-05 9.63774382512664e-05 1.29926331681929 0.553846153846154 19.4 19 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.71950625750563e-08 1.98931496295164e-07 1.29861884096769 0.553571428571429 19.4 19 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 6.22849712152389e-05 0.000316541121568875 1.29861884096769 0.553571428571429 19.4 19 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.52510121515946e-06 2.43505778115141e-05 1.2964140551596 0.552631578947368 19.4 19 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000965530679202967 0.00347835482659702 1.2964140551596 0.552631578947368 19.4 19 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.62978294184824e-14 9.2767245050002e-13 1.29582611227744 0.552380952380952 19.4 19 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.34939472067351e-05 8.24115316531501e-05 1.29549265213532 0.552238805970149 19.4 19 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 8.42463146021497e-13 3.4252144479674e-11 1.29472733377636 0.551912568306011 19.4 19 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.71977048474575e-09 3.83191425722099e-08 1.2930113935975 0.551181102362205 19.4 19 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.000202801993059873 0.000893458935369038 1.29263442234572 0.551020408163265 19.4 19 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0166273724343667 0.0406542112957109 1.29024065489693 0.55 19.4 19 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.07196147411988e-06 1.49665034399624e-05 1.28737981087277 0.548780487804878 19.4 19 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00323980892968017 0.010267813155757 1.28645695796175 0.548387096774194 19.4 19 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000665647176198819 0.00253945290008289 1.28465519751643 0.547619047619048 19.4 19 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 3.03032131533491e-05 0.000168443251239124 1.28290974208502 0.546875 19.4 19 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.44788299480189e-12 9.67593750445301e-11 1.28190825126372 0.546448087431694 19.4 19 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000552550871025959 0.00216010958645588 1.27957750898869 0.545454545454545 19.4 19 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000552550871025959 0.00216010958645588 1.27957750898869 0.545454545454545 19.4 19 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0135769797626017 0.0339543799686859 1.27957750898869 0.545454545454545 19.4 19 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0769236038572615 0.142901159646062 1.27957750898869 0.545454545454545 19.4 19 4 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0769236038572615 0.142901159646062 1.27957750898869 0.545454545454545 19.4 19 4 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0769236038572615 0.142901159646062 1.27957750898869 0.545454545454545 19.4 19 4 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0769236038572615 0.142901159646062 1.27957750898869 0.545454545454545 19.4 19 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0769236038572615 0.142901159646062 1.27957750898869 0.545454545454545 19.4 19 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0769236038572615 0.142901159646062 1.27957750898869 0.545454545454545 19.4 19 4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0769236038572615 0.142901159646062 1.27957750898869 0.545454545454545 19.4 19 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0769236038572615 0.142901159646062 1.27957750898869 0.545454545454545 19.4 19 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.99049067238331e-09 4.17202767333476e-08 1.27957750898869 0.545454545454545 19.4 19 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.52901197285513e-05 0.000143377850094536 1.27957750898869 0.545454545454545 19.4 19 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 9.77665990281631e-18 8.1836394362986e-16 1.27880760675705 0.545126353790614 19.4 19 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000458625032077419 0.00181789253661885 1.27494135859381 0.543478260869565 19.4 19 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.000458625032077419 0.00181789253661885 1.27494135859381 0.543478260869565 19.4 19 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00220850961933489 0.00729166865037945 1.27348428275541 0.542857142857143 19.4 19 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00220850961933489 0.00729166865037945 1.27348428275541 0.542857142857143 19.4 19 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00220850961933489 0.00729166865037945 1.27348428275541 0.542857142857143 19.4 19 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 8.12546545383156e-05 0.000404284522405675 1.27234825752548 0.542372881355932 19.4 19 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000380642959014173 0.00155647968585393 1.27069155406516 0.541666666666667 19.4 19 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0110985338312501 0.0282526183217689 1.27069155406516 0.541666666666667 19.4 19 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.10400642901116e-07 1.1302166535848e-06 1.26979480632058 0.541284403669725 19.4 19 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.39960077999051e-22 2.48953988740812e-20 1.26703263144959 0.540106951871658 19.4 19 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000315911928880308 0.00131062004313901 1.26678173389881 0.54 19.4 19 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000262188236548515 0.00110710344394225 1.26317266912986 0.538461538461538 19.4 19 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00908206254111225 0.0239773191020459 1.26317266912986 0.538461538461538 19.4 19 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00908206254111225 0.0239773191020459 1.26317266912986 0.538461538461538 19.4 19 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00908206254111225 0.0239773191020459 1.26317266912986 0.538461538461538 19.4 19 4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.061186404444892 0.118693516745029 1.26317266912986 0.538461538461538 19.4 19 4 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.061186404444892 0.118693516745029 1.26317266912986 0.538461538461538 19.4 19 4 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.061186404444892 0.118693516745029 1.26317266912986 0.538461538461538 19.4 19 4 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.061186404444892 0.118693516745029 1.26317266912986 0.538461538461538 19.4 19 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.061186404444892 0.118693516745029 1.26317266912986 0.538461538461538 19.4 19 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.06511483095271e-11 3.30938646743052e-10 1.26219194500787 0.53804347826087 19.4 19 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000217604491879933 0.000949850282040323 1.25983094249195 0.537037037037037 19.4 19 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.24443870818727e-05 0.000178947142703507 1.25794214047922 0.536231884057971 19.4 19 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00743927447933488 0.0204364625175551 1.2567279106139 0.535714285714286 19.4 19 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.69973093219673e-05 0.000151248705374643 1.25554788440675 0.535211267605634 19.4 19 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000149908096157678 0.000683715451385819 1.25383888093432 0.53448275862069 19.4 19 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000149908096157678 0.000683715451385819 1.25383888093432 0.53448275862069 19.4 19 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000149908096157678 0.000683715451385819 1.25383888093432 0.53448275862069 19.4 19 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.93412434123535e-19 5.62950595838527e-17 1.25210191830489 0.533742331288344 19.4 19 4 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0489383812870282 0.0986392585997749 1.25114245323339 0.533333333333333 19.4 19 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0489383812870282 0.0986392585997749 1.25114245323339 0.533333333333333 19.4 19 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0489383812870282 0.0986392585997749 1.25114245323339 0.533333333333333 19.4 19 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000103294219758592 0.000488331145237461 1.24861998860993 0.532258064516129 19.4 19 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.2863625875699e-13 1.79396881238587e-11 1.24758807126398 0.531818181818182 19.4 19 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.14658267149037e-06 8.58730074489894e-06 1.24332281290068 0.53 19.4 19 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00411003226167855 0.0123066243840583 1.24194287637138 0.529411764705882 19.4 19 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0393144921032565 0.0820300912946246 1.24194287637138 0.529411764705882 19.4 19 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 4.90841427847072e-05 0.000252154278637683 1.23997153847238 0.528571428571429 19.4 19 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 4.90841427847072e-05 0.000252154278637683 1.23997153847238 0.528571428571429 19.4 19 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 8.60499265547928e-08 9.07029966573853e-07 1.23969907713674 0.528455284552846 19.4 19 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.07606256380836e-05 0.000216426754787287 1.23810971934554 0.527777777777778 19.4 19 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00337770016565237 0.0106371168979356 1.23810971934554 0.527777777777778 19.4 19 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.00337770016565237 0.0106371168979356 1.23810971934554 0.527777777777778 19.4 19 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.79070839926589e-09 5.13731243062415e-08 1.23468005253295 0.526315789473684 19.4 19 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.8115360674875e-05 0.00015689473819744 1.23468005253295 0.526315789473684 19.4 19 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00277775145549769 0.00896312997998462 1.23468005253295 0.526315789473684 19.4 19 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0316966762465332 0.067724279727953 1.23468005253295 0.526315789473684 19.4 19 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0316966762465332 0.067724279727953 1.23468005253295 0.526315789473684 19.4 19 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00228581750308677 0.00752944052521407 1.23159335240162 0.525 19.4 19 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.25774811295756e-09 4.50075297547437e-08 1.22458518417891 0.522012578616352 19.4 19 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00127809076471641 0.00449067446467025 1.22394370425005 0.521739130434783 19.4 19 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0207793624058264 0.0493639944966461 1.22394370425005 0.521739130434783 19.4 19 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000869596603508093 0.00316479786903329 1.21986389190255 0.52 19.4 19 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0168824719418539 0.0410987289274177 1.21986389190255 0.52 19.4 19 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.90290484496076e-09 8.32443524947387e-08 1.21805935951808 0.519230769230769 19.4 19 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.45880812188532e-05 0.000189303229132416 1.21748830496604 0.518987341772152 19.4 19 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0137423342734805 0.0342475335747159 1.21638849619913 0.518518518518518 19.4 19 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0137423342734805 0.0342475335747159 1.21638849619913 0.518518518518518 19.4 19 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 4.00787884965456e-07 3.60706814617834e-06 1.21140329744421 0.516393442622951 19.4 19 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00914926589746279 0.024110009948314 1.21078301925812 0.516129032258065 19.4 19 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.00947104005889e-08 1.1970644083365e-07 1.21030101964854 0.515923566878981 19.4 19 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0074805787773709 0.0205103344897857 1.20848986960043 0.515151515151515 19.4 19 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 7.65522458031007e-08 8.12939147595614e-07 1.20645879418934 0.514285714285714 19.4 19 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.65522458031007e-08 8.12939147595614e-07 1.20645879418934 0.514285714285714 19.4 19 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00612340917710125 0.0173232828211035 1.20645879418934 0.514285714285714 19.4 19 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.55910761541757e-06 1.80277729541545e-05 1.20583238775414 0.514018691588785 19.4 19 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 8.88871218331719e-05 0.00043169411047305 1.20464729449836 0.513513513513513 19.4 19 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 8.88871218331719e-05 0.00043169411047305 1.20464729449836 0.513513513513513 19.4 19 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0041157066175487 0.0123066243840583 1.20302158964749 0.512820512820513 19.4 19 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00337876095422832 0.0106371168979356 1.20155449014792 0.51219512195122 19.4 19 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.316343942924e-07 2.27321202122817e-06 1.19940347960344 0.511278195488722 19.4 19 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 7.79424141441454e-06 4.97363476803224e-05 1.19640497090443 0.51 19.4 19 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 5.37155646516147e-06 3.60553058958715e-05 1.19550270471219 0.509615384615385 19.4 19 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.07578994270238e-06 2.13504833583682e-05 1.19427234172278 0.509090909090909 19.4 19 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000589332717137748 0.00228506936372484 1.19282649143014 0.508474576271186 19.4 19 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.000187744488785406 0.000840127067740985 1.18946641680639 0.507042253521127 19.4 19 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 9.98525911749548e-07 7.55799134265748e-06 1.18218184557486 0.503937007874016 19.4 19 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.29031457020902e-07 3.00135745731246e-06 1.181384510697 0.503597122302158 19.4 19 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.51621827699971e-08 8.1027110667959e-07 1.18051344377667 0.503225806451613 19.4 19 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 8.854058717101e-08 9.26420996649612e-07 1.1729460499063 0.5 19.4 19 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.05287833188459e-06 1.49043156442437e-05 1.1729460499063 0.5 19.4 19 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 7.54424812870334e-06 4.83579508429948e-05 1.1729460499063 0.5 19.4 19 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.000183456345728218 0.000823528012527616 1.1729460499063 0.5 19.4 19 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00725778590423884 0.0199764590749166 1.1729460499063 0.5 19.4 19 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00725778590423884 0.0199764590749166 1.1729460499063 0.5 19.4 19 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00886911818855018 0.0235461850416174 1.1729460499063 0.5 19.4 19 4 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00886911818855018 0.0235461850416174 1.1729460499063 0.5 19.4 19 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0132937143713126 0.0333044992084118 1.1729460499063 0.5 19.4 19 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0163104181705255 0.0399478916637827 1.1729460499063 0.5 19.4 19 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0163104181705255 0.0399478916637827 1.1729460499063 0.5 19.4 19 4 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0304601909804029 0.065973899185865 1.1729460499063 0.5 19.4 19 4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0304601909804029 0.065973899185865 1.1729460499063 0.5 19.4 19 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0304601909804029 0.065973899185865 1.1729460499063 0.5 19.4 19 4 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0582423584698152 0.114631917154284 1.1729460499063 0.5 19.4 19 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0582423584698152 0.114631917154284 1.1729460499063 0.5 19.4 19 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0582423584698152 0.114631917154284 1.1729460499063 0.5 19.4 19 4 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0582423584698152 0.114631917154284 1.1729460499063 0.5 19.4 19 4 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0728521167731291 0.13676591315061 1.1729460499063 0.5 19.4 19 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0728521167731291 0.13676591315061 1.1729460499063 0.5 19.4 19 4 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0728521167731291 0.13676591315061 1.1729460499063 0.5 19.4 19 4 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.091622463750415 0.161400965501502 1.1729460499063 0.5 19.4 19 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.091622463750415 0.161400965501502 1.1729460499063 0.5 19.4 19 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.091622463750415 0.161400965501502 1.1729460499063 0.5 19.4 19 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.091622463750415 0.161400965501502 1.1729460499063 0.5 19.4 19 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.091622463750415 0.161400965501502 1.1729460499063 0.5 19.4 19 4 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.116032493383297 0.197033696998128 1.1729460499063 0.5 19.4 19 4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.116032493383297 0.197033696998128 1.1729460499063 0.5 19.4 19 4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.116032493383297 0.197033696998128 1.1729460499063 0.5 19.4 19 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 8.61391680771109e-05 0.000421223492005941 1.1729460499063 0.5 19.4 19 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 8.61391680771109e-05 0.000421223492005941 1.1729460499063 0.5 19.4 19 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00182927078901192 0.00609614129452919 1.1729460499063 0.5 19.4 19 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00182927078901192 0.00609614129452919 1.1729460499063 0.5 19.4 19 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0048754039480763 0.0141297348637731 1.1729460499063 0.5 19.4 19 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0048754039480763 0.0141297348637731 1.1729460499063 0.5 19.4 19 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0246828813425956 0.0567579629925854 1.1729460499063 0.5 19.4 19 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0246828813425956 0.0567579629925854 1.1729460499063 0.5 19.4 19 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0467659800586996 0.0952045631237905 1.1729460499063 0.5 19.4 19 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0467659800586996 0.0952045631237905 1.1729460499063 0.5 19.4 19 4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.148310641399456 0.245117355065535 1.1729460499063 0.5 19.4 19 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.19038367900605e-06 2.86678652655077e-05 1.16325228089881 0.495867768595041 19.4 19 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000177045334672348 0.000802342392480098 1.15846523447536 0.493827160493827 19.4 19 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000810855061947507 0.00296618702609589 1.15490072606159 0.492307692307692 19.4 19 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.63215240451688e-30 9.36388217906879e-28 1.15342197993347 0.491677336747759 19.4 19 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00381127835515348 0.0117390673146827 1.14900837541842 0.489795918367347 19.4 19 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 9.61927190191305e-05 0.000465585847497356 1.14744722273443 0.489130434782609 19.4 19 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.47016910772786e-20 1.60926972330519e-18 1.14658771170616 0.48876404494382 19.4 19 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00839020028227949 0.0225803756527911 1.14433760966469 0.48780487804878 19.4 19 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 4.03038534955978e-07 3.60706814617834e-06 1.14362239865864 0.4875 19.4 19 4 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0125177650915119 0.0314158372578861 1.14124480531424 0.486486486486487 19.4 19 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0125177650915119 0.0314158372578861 1.14124480531424 0.486486486486487 19.4 19 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000769328702876321 0.00290848229330099 1.13943330562327 0.485714285714286 19.4 19 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.015316190513694 0.0379042419147593 1.13943330562327 0.485714285714286 19.4 19 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.015316190513694 0.0379042419147593 1.13943330562327 0.485714285714286 19.4 19 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 4.32549665024831e-05 0.000226293446077329 1.13943330562327 0.485714285714286 19.4 19 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 4.5392608360538e-10 8.1764154046893e-09 1.13570966736959 0.484126984126984 19.4 19 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 4.5392608360538e-10 8.1764154046893e-09 1.13570966736959 0.484126984126984 19.4 19 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 4.5392608360538e-10 8.1764154046893e-09 1.13570966736959 0.484126984126984 19.4 19 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0230239984265217 0.0536221763681512 1.13510908055449 0.483870967741935 19.4 19 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0230239984265217 0.0536221763681512 1.13510908055449 0.483870967741935 19.4 19 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000193200688981204 0.000859239339494526 1.13340854260609 0.48314606741573 19.4 19 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000281357078136209 0.00117067579587083 1.13154795402726 0.482352941176471 19.4 19 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000281357078136209 0.00117067579587083 1.13154795402726 0.482352941176471 19.4 19 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000281357078136209 0.00117067579587083 1.13154795402726 0.482352941176471 19.4 19 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000281357078136209 0.00117067579587083 1.13154795402726 0.482352941176471 19.4 19 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000281357078136209 0.00117067579587083 1.13154795402726 0.482352941176471 19.4 19 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000339637742447491 0.00139683383671324 1.13055040954824 0.481927710843373 19.4 19 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0348419607639166 0.0740625573453212 1.12950360361348 0.481481481481481 19.4 19 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0348419607639166 0.0740625573453212 1.12950360361348 0.481481481481481 19.4 19 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00434363660346092 0.0127443193540719 1.12783274029452 0.480769230769231 19.4 19 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0429934700929096 0.08892399410205 1.12602820791005 0.48 19.4 19 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00641727472040315 0.0180827364893736 1.12407329782687 0.479166666666667 19.4 19 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00641727472040315 0.0180827364893736 1.12407329782687 0.479166666666667 19.4 19 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00031807285155758 0.00131574903420476 1.11963032036511 0.477272727272727 19.4 19 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0659791969563712 0.127047898875394 1.11709147610124 0.476190476190476 19.4 19 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0659791969563712 0.127047898875394 1.11709147610124 0.476190476190476 19.4 19 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.52220648036536e-07 2.43953212415637e-06 1.11649410098033 0.475935828877005 19.4 19 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 6.41891189276412e-06 4.24842401088528e-05 1.1155291104004 0.475524475524476 19.4 19 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 9.92519158444944e-08 1.02344548004866e-06 1.10592056134023 0.471428571428571 19.4 19 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00173022160473294 0.0057931890436117 1.10592056134023 0.471428571428571 19.4 19 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0257993679412086 0.0585526325045292 1.10394922344123 0.470588235294118 19.4 19 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0257993679412086 0.0585526325045292 1.10394922344123 0.470588235294118 19.4 19 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.102663338701905 0.176224283441267 1.10394922344123 0.470588235294118 19.4 19 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.102663338701905 0.176224283441267 1.10394922344123 0.470588235294118 19.4 19 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.102663338701905 0.176224283441267 1.10394922344123 0.470588235294118 19.4 19 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00872257919735477 0.0232438767749735 1.10113302644265 0.469387755102041 19.4 19 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.74502084862849e-15 1.18245936552302e-13 1.09665687592866 0.467479674796748 19.4 19 4 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0387845010541537 0.0810430910426736 1.09474964657922 0.466666666666667 19.4 19 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0387845010541537 0.0810430910426736 1.09474964657922 0.466666666666667 19.4 19 4 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0387845010541537 0.0810430910426736 1.09474964657922 0.466666666666667 19.4 19 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.128971035905878 0.216421915205265 1.09474964657922 0.466666666666667 19.4 19 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0156777103156621 0.0385308839018777 1.091112604564 0.465116279069767 19.4 19 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0156777103156621 0.0385308839018777 1.091112604564 0.465116279069767 19.4 19 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0476656519007017 0.0966213997930177 1.08916418919871 0.464285714285714 19.4 19 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00279459904172655 0.00899709148501557 1.08794995933338 0.463768115942029 19.4 19 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 8.10133757903303e-29 1.92136722916067e-26 1.08723527749073 0.463463463463463 19.4 19 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0232594479030261 0.0539937917879383 1.08271943068274 0.461538461538462 19.4 19 4 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0586882604503216 0.114716201402208 1.08271943068274 0.461538461538462 19.4 19 4 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0586882604503216 0.114716201402208 1.08271943068274 0.461538461538462 19.4 19 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0586882604503216 0.114716201402208 1.08271943068274 0.461538461538462 19.4 19 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0586882604503216 0.114716201402208 1.08271943068274 0.461538461538462 19.4 19 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0586882604503216 0.114716201402208 1.08271943068274 0.461538461538462 19.4 19 4 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.163043426759072 0.262455651898371 1.08271943068274 0.461538461538462 19.4 19 4 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.163043426759072 0.262455651898371 1.08271943068274 0.461538461538462 19.4 19 4 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.163043426759072 0.262455651898371 1.08271943068274 0.461538461538462 19.4 19 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00191527987604201 0.00636785809254153 1.07158034188971 0.45679012345679 19.4 19 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0171514083043084 0.0415782862300355 1.0709507412188 0.456521739130435 19.4 19 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0104850395662882 0.0271770697683573 1.06631459082391 0.454545454545455 19.4 19 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0208198651472707 0.0493777801742769 1.06631459082391 0.454545454545455 19.4 19 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0895569417700802 0.159100534505398 1.06631459082391 0.454545454545455 19.4 19 4 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.207799839351285 0.32071493643913 1.06631459082391 0.454545454545455 19.4 19 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0423134118214917 0.0876448108034682 1.06631459082391 0.454545454545455 19.4 19 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0423134118214917 0.0876448108034682 1.06631459082391 0.454545454545455 19.4 19 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.000906373728841205 0.00329022912280876 1.06411600403871 0.45360824742268 19.4 19 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.80343807310791e-15 1.73447494697068e-13 1.06407364947717 0.453590192644483 19.4 19 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 4.37762156526728e-06 2.98055286477289e-05 1.06298235772759 0.453125 19.4 19 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00646173820270844 0.0181720424159172 1.06298235772759 0.453125 19.4 19 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.4211054639905e-05 0.000187962666998397 1.06088114067959 0.452229299363057 19.4 19 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0517637385122038 0.104039265399528 1.05943514185085 0.451612903225806 19.4 19 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 7.18880812366758e-12 2.69201946315236e-10 1.0572293992429 0.45067264573991 19.4 19 4 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.111070511717007 0.189967954535217 1.05565144491567 0.45 19.4 19 4 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.111070511717007 0.189967954535217 1.05565144491567 0.45 19.4 19 4 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.111070511717007 0.189967954535217 1.05565144491567 0.45 19.4 19 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.30895291524052e-37 9.31319999193627e-35 1.0540612662812 0.44932214331827 19.4 19 4 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0634030100568975 0.122584895802942 1.05160680336427 0.448275862068966 19.4 19 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 8.63762153053813e-06 5.43864399909547e-05 1.05076416970773 0.447916666666667 19.4 19 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.93192155770414e-16 4.44269704032263e-14 1.05072616601249 0.447900466562986 19.4 19 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000793036633732105 0.00290848229330099 1.04498829900743 0.445454545454545 19.4 19 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 8.02154933799493e-05 0.000400514551156729 1.04430035411013 0.445161290322581 19.4 19 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0271670205214965 0.0605935269625227 1.04261871102782 0.444444444444444 19.4 19 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0777653001994455 0.144088570551837 1.04261871102782 0.444444444444444 19.4 19 4 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0777653001994455 0.144088570551837 1.04261871102782 0.444444444444444 19.4 19 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0198648635432676 0.0476689727184987 1.03760612107096 0.442307692307692 19.4 19 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0553508148848731 0.110779479017123 1.03495239697615 0.441176470588235 19.4 19 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000108913981785982 0.000508152858165315 1.03278268545209 0.440251572327044 19.4 19 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000108913981785982 0.000508152858165315 1.03278268545209 0.440251572327044 19.4 19 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0239618544475254 0.0555337441023269 1.03219252391755 0.44 19.4 19 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0955248384110285 0.166992438647289 1.03219252391755 0.44 19.4 19 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0955248384110285 0.166992438647289 1.03219252391755 0.44 19.4 19 4 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0955248384110285 0.166992438647289 1.03219252391755 0.44 19.4 19 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0955248384110285 0.166992438647289 1.03219252391755 0.44 19.4 19 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0955248384110285 0.166992438647289 1.03219252391755 0.44 19.4 19 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0955248384110285 0.166992438647289 1.03219252391755 0.44 19.4 19 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0398380828249504 0.0828795202630182 1.02990384869822 0.439024390243902 19.4 19 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0289057495547272 0.0633788622748486 1.02632779366801 0.4375 19.4 19 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0289057495547272 0.0633788622748486 1.02632779366801 0.4375 19.4 19 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.172619084120239 0.275069380406607 1.02632779366801 0.4375 19.4 19 4 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0482631022258199 0.0976933064969299 1.02256835120037 0.435897435897436 19.4 19 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0154815106924267 0.0382468571446584 1.02159817249904 0.435483870967742 19.4 19 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0348713376116411 0.0740625573453212 1.01995308687505 0.434782608695652 19.4 19 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.117536461934624 0.19911236349163 1.01995308687505 0.434782608695652 19.4 19 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00842506635249992 0.0225803756527911 1.01861104333968 0.434210526315789 19.4 19 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0822289287060544 0.151322068984081 1.01655324325213 0.433333333333333 19.4 19 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0366743016818473 0.0777757545354228 1.00538232849112 0.428571428571429 19.4 19 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0507518536553606 0.102149770511426 1.00538232849112 0.428571428571429 19.4 19 4 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.100340036423503 0.172861830303445 1.00538232849112 0.428571428571429 19.4 19 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.144888997787484 0.24199183550656 1.00538232849112 0.428571428571429 19.4 19 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0612235005557636 0.118693516745029 0.997004142420357 0.425 19.4 19 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0859529799420902 0.156608310445063 0.99522695143565 0.424242424242424 19.4 19 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0859529799420902 0.156608310445063 0.99522695143565 0.424242424242424 19.4 19 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000485036451773769 0.00191482936094637 0.993046349000428 0.423312883435583 19.4 19 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00855899675128304 0.0228507549288476 0.990487775476433 0.422222222222222 19.4 19 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0529589729619122 0.106291422460932 0.990487775476433 0.422222222222222 19.4 19 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 2.44898614814925e-05 0.000141089363919691 0.989231608354713 0.421686746987952 19.4 19 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.178975868645254 0.284879934096417 0.98774404202636 0.421052631578947 19.4 19 4 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0333354210857525 0.0711188968591092 0.98774404202636 0.421052631578947 19.4 19 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 5.0410823558997e-05 0.000258038136418895 0.986684230822469 0.420600858369099 19.4 19 4 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0636100421512675 0.122818303909435 0.982001344107602 0.418604651162791 19.4 19 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0398025531732267 0.0828795202630182 0.981009423557998 0.418181818181818 19.4 19 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0549130103372469 0.110058047478736 0.977455041588585 0.416666666666667 19.4 19 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.149768908780029 0.246953832206235 0.977455041588585 0.416666666666667 19.4 19 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.149768908780029 0.246953832206235 0.977455041588585 0.416666666666667 19.4 19 4 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.273347943614133 0.400178093748335 0.977455041588585 0.416666666666667 19.4 19 4 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.273347943614133 0.400178093748335 0.977455041588585 0.416666666666667 19.4 19 4 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.273347943614133 0.400178093748335 0.977455041588585 0.416666666666667 19.4 19 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0474964573384689 0.0964157757384326 0.973766531997685 0.415094339622642 19.4 19 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.69009744781437e-08 3.03810211765068e-07 0.971531071639564 0.414141414141414 19.4 19 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.126413231505814 0.212380198858055 0.97071397233625 0.413793103448276 19.4 19 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000944764708535387 0.00341218319859354 0.968362436550552 0.412790697674419 19.4 19 4 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.221588105913073 0.334025291010915 0.965955570511073 0.411764705882353 19.4 19 4 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.221588105913073 0.334025291010915 0.965955570511073 0.411764705882353 19.4 19 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.221588105913073 0.334025291010915 0.965955570511073 0.411764705882353 19.4 19 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.221588105913073 0.334025291010915 0.965955570511073 0.411764705882353 19.4 19 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000503361383011624 0.00197868300559542 0.964554619719904 0.411167512690355 19.4 19 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.091645804726081 0.161400965501502 0.962417271717992 0.41025641025641 19.4 19 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.091645804726081 0.161400965501502 0.962417271717992 0.41025641025641 19.4 19 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0115957920328124 0.0294657358262359 0.961815760923168 0.41 19.4 19 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.017868963383399 0.0429519170516499 0.95968313174152 0.409090909090909 19.4 19 4 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.183195805799532 0.29094601746957 0.95968313174152 0.409090909090909 19.4 19 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0156010994577728 0.0384755017823409 0.958536556912677 0.408602150537634 19.4 19 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000130436551684606 0.000602633808594789 0.956755993649062 0.407843137254902 19.4 19 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0581621338125268 0.114631917154284 0.955733818442172 0.407407407407407 19.4 19 4 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.153319786157867 0.252516268174357 0.955733818442172 0.407407407407407 19.4 19 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.129405273956772 0.216639652753513 0.953018665548871 0.40625 19.4 19 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.129405273956772 0.216639652753513 0.953018665548871 0.40625 19.4 19 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0284289365667704 0.0625260845973946 0.950234774607638 0.40506329113924 19.4 19 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00483829737896827 0.0140795443154844 0.948339359498713 0.404255319148936 19.4 19 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0704018542387267 0.13286715992269 0.938356839925042 0.4 19.4 19 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.131695195184986 0.220214174792286 0.938356839925042 0.4 19.4 19 4 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.275034557755356 0.400178093748335 0.938356839925042 0.4 19.4 19 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.275034557755356 0.400178093748335 0.938356839925042 0.4 19.4 19 4 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.275034557755356 0.400178093748335 0.938356839925042 0.4 19.4 19 4 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.275034557755356 0.400178093748335 0.938356839925042 0.4 19.4 19 4 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.224246106597419 0.337317346393369 0.938356839925042 0.4 19.4 19 4 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0616983080362469 0.119451282089224 0.9309095634177 0.396825396825397 19.4 19 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.000558697013685954 0.00217287973916102 0.929157263063032 0.396078431372549 19.4 19 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0406354325611229 0.0844149204882889 0.926772187580288 0.395061728395062 19.4 19 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00935940412078494 0.0243927327177234 0.925140546404971 0.394366197183099 19.4 19 4 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.157649265066315 0.258450350448578 0.92413931204739 0.393939393939394 19.4 19 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.157649265066315 0.258450350448578 0.92413931204739 0.393939393939394 19.4 19 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.157649265066315 0.258450350448578 0.92413931204739 0.393939393939394 19.4 19 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0139511138052814 0.0347070540995026 0.923579566855356 0.393700787401575 19.4 19 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.03113738070862 0.0667296577535636 0.923383060564536 0.393617021276596 19.4 19 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.072547017863823 0.136734313139364 0.922973940909877 0.39344262295082 19.4 19 4 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.187600800691867 0.297278328935998 0.921600467783523 0.392857142857143 19.4 19 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.187600800691867 0.297278328935998 0.921600467783523 0.392857142857143 19.4 19 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0474824740555528 0.0964157757384326 0.920539937901149 0.392405063291139 19.4 19 4 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.225405383998403 0.338566570647644 0.917957778187541 0.391304347826087 19.4 19 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.274653186020208 0.400178093748335 0.912291372149346 0.388888888888889 19.4 19 4 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.274653186020208 0.400178093748335 0.912291372149346 0.388888888888889 19.4 19 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.115718814993659 0.197033696998128 0.909631630539581 0.387755102040816 19.4 19 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.188482823248556 0.298207619404789 0.908087264443589 0.387096774193548 19.4 19 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.016895823206282 0.0410987289274177 0.907534899927504 0.386861313868613 19.4 19 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.016895823206282 0.0410987289274177 0.907534899927504 0.386861313868613 19.4 19 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0170447408482986 0.0413902154046569 0.904844095642005 0.385714285714286 19.4 19 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0252316834863013 0.0574474969616109 0.903745317140922 0.385245901639344 19.4 19 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.225552430761747 0.338566570647644 0.902266192235617 0.384615384615385 19.4 19 4 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.342288266648546 0.473481358850794 0.902266192235617 0.384615384615385 19.4 19 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.342288266648546 0.473481358850794 0.902266192235617 0.384615384615385 19.4 19 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0378984024063422 0.079541927174373 0.898893234507633 0.383177570093458 19.4 19 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0225406407089107 0.0526688534134317 0.896958744045996 0.382352941176471 19.4 19 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.159846281066791 0.260982105625744 0.893673180880992 0.380952380952381 19.4 19 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.273081250480456 0.400178093748335 0.893673180880992 0.380952380952381 19.4 19 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.017779976916764 0.0428148124880035 0.888816261419683 0.37888198757764 19.4 19 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.188606365048707 0.298207619404789 0.887634848577742 0.378378378378378 19.4 19 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.117289573278023 0.198930944904203 0.884516693371966 0.377049180327869 19.4 19 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0203639928583199 0.0485119873299684 0.883329741287462 0.376543209876543 19.4 19 4 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.223929352823626 0.337197321765101 0.879709537429727 0.375 19.4 19 4 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.336483841936427 0.473481358850794 0.879709537429727 0.375 19.4 19 4 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.336483841936427 0.473481358850794 0.879709537429727 0.375 19.4 19 4 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.336483841936427 0.473481358850794 0.879709537429727 0.375 19.4 19 4 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.336483841936427 0.473481358850794 0.879709537429727 0.375 19.4 19 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0263989174376177 0.0596265343113503 0.877817688962136 0.374193548387097 19.4 19 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0869930521351232 0.158300656250998 0.864276036773065 0.368421052631579 19.4 19 4 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.330464954488931 0.468845094952891 0.864276036773065 0.368421052631579 19.4 19 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.265012229231832 0.392008734092408 0.860160436597955 0.366666666666667 19.4 19 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.114513373316262 0.195386726893335 0.85556064816695 0.364705882352941 19.4 19 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.114513373316262 0.195386726893335 0.85556064816695 0.364705882352941 19.4 19 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.182338318524468 0.289907739955662 0.853051672659129 0.363636363636364 19.4 19 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.324444361726697 0.461223103633456 0.853051672659129 0.363636363636364 19.4 19 4 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.324444361726697 0.461223103633456 0.853051672659129 0.363636363636364 19.4 19 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.261803688684946 0.387665607698937 0.853051672659129 0.363636363636364 19.4 19 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.261803688684946 0.387665607698937 0.853051672659129 0.363636363636364 19.4 19 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.261803688684946 0.387665607698937 0.853051672659129 0.363636363636364 19.4 19 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.153712648798457 0.252870634959774 0.849960905729205 0.36231884057971 19.4 19 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.312731900045949 0.445462956722108 0.83781860707593 0.357142857142857 19.4 19 4 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.41210999866687 0.549608742364532 0.83781860707593 0.357142857142857 19.4 19 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.41210999866687 0.549608742364532 0.83781860707593 0.357142857142857 19.4 19 4 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.41210999866687 0.549608742364532 0.83781860707593 0.357142857142857 19.4 19 4 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.41210999866687 0.549608742364532 0.83781860707593 0.357142857142857 19.4 19 4 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.41210999866687 0.549608742364532 0.83781860707593 0.357142857142857 19.4 19 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.41210999866687 0.549608742364532 0.83781860707593 0.357142857142857 19.4 19 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.41210999866687 0.549608742364532 0.83781860707593 0.357142857142857 19.4 19 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.301639296253701 0.430524291443346 0.827961917580919 0.352941176470588 19.4 19 4 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.39915424340371 0.536858684653572 0.827961917580919 0.352941176470588 19.4 19 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.39915424340371 0.536858684653572 0.827961917580919 0.352941176470588 19.4 19 4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.377265149848453 0.508379079767376 0.815962469500036 0.347826086956522 19.4 19 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.3589101610789 0.484103468450498 0.808928310280209 0.344827586206897 19.4 19 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.25917177542486 0.384970184164483 0.807602198296143 0.344262295081967 19.4 19 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.328687643076434 0.466788938221322 0.80103632676528 0.341463414634146 19.4 19 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.303973686915793 0.433421399279733 0.79671807163447 0.339622641509434 19.4 19 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.430504090207966 0.56828137325226 0.781964033270868 0.333333333333333 19.4 19 4 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.405859127002435 0.544846733702325 0.781964033270868 0.333333333333333 19.4 19 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.405859127002435 0.544846733702325 0.781964033270868 0.333333333333333 19.4 19 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.480647719122626 0.618969868155201 0.781964033270868 0.333333333333333 19.4 19 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.480647719122626 0.618969868155201 0.781964033270868 0.333333333333333 19.4 19 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.434387823651993 0.572876620071164 0.748688968025299 0.319148936170213 19.4 19 4 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.521838534067705 0.649105099631419 0.74080803151977 0.315789473684211 19.4 19 4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.521838534067705 0.649105099631419 0.74080803151977 0.315789473684211 19.4 19 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.35761501633938 0.482814201376601 0.735468874535844 0.313513513513514 19.4 19 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.230127689004314 0.345070286041242 0.718644018869422 0.306341463414634 19.4 19 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.509600169617403 0.634992155311352 0.718130234636512 0.306122448979592 19.4 19 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.501880482900964 0.634087358486098 0.710876393882608 0.303030303030303 19.4 19 4 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.57934374063749 0.704620634980468 0.703767629943781 0.3 19.4 19 4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.57934374063749 0.704620634980468 0.703767629943781 0.3 19.4 19 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.544105261480175 0.670937423818275 0.699256298982603 0.298076923076923 19.4 19 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.583759449361224 0.709384881674655 0.695079140685216 0.296296296296296 19.4 19 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.608336152703486 0.73861974854698 0.681065448332692 0.290322580645161 19.4 19 4 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.630026663135717 0.758248045514269 0.670254885660744 0.285714285714286 19.4 19 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.63036362462641 0.758248045514269 0.670254885660744 0.285714285714286 19.4 19 4 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.630026663135717 0.758248045514269 0.670254885660744 0.285714285714286 19.4 19 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.649809315180604 0.767547508459476 0.663931726362058 0.283018867924528 19.4 19 4 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.654902210190731 0.767547508459476 0.656849787947529 0.28 19.4 19 4 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.654902210190731 0.767547508459476 0.656849787947529 0.28 19.4 19 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.826882707313394 0.931392316275022 0.629385685315577 0.268292682926829 19.4 19 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.71423186629077 0.828998324414165 0.617340026266475 0.263157894736842 19.4 19 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.727454675627711 0.843657704497338 0.611971852125027 0.260869565217391 19.4 19 4 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.776112831782238 0.8835268477009 0.586473024953151 0.25 19.4 19 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.975937508887603 1 0.554942217159971 0.236559139784946 19.4 19 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.837365614268071 0.935299269311982 0.547374823289608 0.233333333333333 19.4 19 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.834479158744029 0.934275250112316 0.54135971534137 0.230769230769231 19.4 19 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999140580246851 1 0.538104115678665 0.229381443298969 19.4 19 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.936846838197709 1 0.534507060716796 0.227848101265823 19.4 19 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.862551580918001 0.961167501680748 0.529717570925427 0.225806451612903 19.4 19 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.934483748317335 1 0.52865174080284 0.225352112676056 19.4 19 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.884446079912647 0.979880207787388 0.513163896834007 0.21875 19.4 19 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999453408514253 1 0.502691164245558 0.214285714285714 19.4 19 4 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.918430186762026 1 0.49387202101318 0.210526315789474 19.4 19 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999720820846882 1 0.464854194893742 0.19815668202765 19.4 19 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999866109627861 1 0.426525836329565 0.181818181818182 19.4 19 4 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.988387439757024 1 0.390982016635434 0.166666666666667 19.4 19 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.988387439757024 1 0.390982016635434 0.166666666666667 19.4 19 4 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.975407886758149 1 0.378369693518162 0.161290322580645 19.4 19 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.378179079062989 0.161209068010076 19.4 19 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.305432606123883 0.130198915009042 19.4 19 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999160173733 1 0.260654677756956 0.111111111111111 19.4 19 4 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999586567366686 1 0.249562989341766 0.106382978723404 19.4 19 4 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999942908693 1 0.182458274429869 0.0777777777777778 19.4 19 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 4.26549554658233e-09 2.35263572201033e-08 1.62001853568119 1 2.1 2 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 7.69136804337845e-08 3.58846450023854e-07 1.62001853568119 1 2.1 2 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 7.69136804337845e-08 3.58846450023854e-07 1.62001853568119 1 2.1 2 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 7.69136804337845e-08 3.58846450023854e-07 1.62001853568119 1 2.1 2 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 6.54670499227297e-05 0.000210292577968497 1.62001853568119 1 2.1 2 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 6.54670499227297e-05 0.000210292577968497 1.62001853568119 1 2.1 2 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 6.54670499227297e-05 0.000210292577968497 1.62001853568119 1 2.1 2 1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.00809600473063529 0.0170423294847545 1.62001853568119 1 2.1 2 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 2.93323149110588e-08 1.4749075660225e-07 1.62001853568119 1 2.1 2 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 2.01669430571355e-07 9.08150631971641e-07 1.62001853568119 1 2.1 2 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 9.52748492804358e-06 3.56020082825669e-05 1.62001853568119 1 2.1 2 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 2.49753108421382e-05 8.62618139037929e-05 1.62001853568119 1 2.1 2 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 2.49753108421382e-05 8.62618139037929e-05 1.62001853568119 1 2.1 2 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 2.49753108421382e-05 8.62618139037929e-05 1.62001853568119 1 2.1 2 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 2.49753108421382e-05 8.62618139037929e-05 1.62001853568119 1 2.1 2 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000171598655083807 0.000509780555708261 1.62001853568119 1 2.1 2 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000171598655083807 0.000509780555708261 1.62001853568119 1 2.1 2 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000171598655083807 0.000509780555708261 1.62001853568119 1 2.1 2 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000171598655083807 0.000509780555708261 1.62001853568119 1 2.1 2 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00044976352286108 0.00125002635357679 1.62001853568119 1 2.1 2 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00044976352286108 0.00125002635357679 1.62001853568119 1 2.1 2 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00044976352286108 0.00125002635357679 1.62001853568119 1 2.1 2 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00044976352286108 0.00125002635357679 1.62001853568119 1 2.1 2 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.00308931835338932 0.00735133782085786 1.62001853568119 1 2.1 2 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 1.38627920925159e-06 5.71789946308701e-06 1.62001853568119 1 2.1 2 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 1.38627920925159e-06 5.71789946308701e-06 1.62001853568119 1 2.1 2 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00117878289196192 0.00307781294543453 1.62001853568119 1 2.1 2 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00117878289196192 0.00307781294543453 1.62001853568119 1 2.1 2 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00117878289196192 0.00307781294543453 1.62001853568119 1 2.1 2 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00117878289196192 0.00307781294543453 1.62001853568119 1 2.1 2 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00117878289196192 0.00307781294543453 1.62001853568119 1 2.1 2 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 3.60146484083292e-09 2.02564603498231e-08 1.55251776336114 0.958333333333333 2.1 2 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 2.27591234840965e-08 1.15665116849533e-07 1.54638132951386 0.954545454545455 2.1 2 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 5.70457188742786e-08 2.78955525629204e-07 1.54287479588684 0.952380952380952 2.1 2 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 1.42672231698042e-07 6.59164239306213e-07 1.53901760889713 0.95 2.1 2 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 1.42672231698042e-07 6.59164239306213e-07 1.53901760889713 0.95 2.1 2 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 3.61823927006136e-12 3.19798414987411e-11 1.52744604792798 0.942857142857143 2.1 2 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 2.19776143277249e-06 8.91001287417453e-06 1.52472332769994 0.941176470588235 2.1 2 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 6.7552194546375e-32 5.65451604938186e-30 1.52183559412475 0.939393939393939 2.1 2 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.4798519613959e-16 5.26690946427816e-15 1.52083372737417 0.938775510204082 2.1 2 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.43506366320386e-06 2.0734840731204e-05 1.51876737720111 0.9375 2.1 2 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.43506366320386e-06 2.0734840731204e-05 1.51876737720111 0.9375 2.1 2 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 5.43506366320386e-06 2.0734840731204e-05 1.51876737720111 0.9375 2.1 2 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 5.43506366320386e-06 2.0734840731204e-05 1.51876737720111 0.9375 2.1 2 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 5.43506366320386e-06 2.0734840731204e-05 1.51876737720111 0.9375 2.1 2 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 5.43506366320386e-06 2.0734840731204e-05 1.51876737720111 0.9375 2.1 2 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.11896093109142e-33 9.95175878089428e-32 1.51403601465531 0.934579439252336 2.1 2 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 1.33915961572216e-05 4.84891636939601e-05 1.51201729996911 0.933333333333333 2.1 2 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 1.33915961572216e-05 4.84891636939601e-05 1.51201729996911 0.933333333333333 2.1 2 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 1.33915961572216e-05 4.84891636939601e-05 1.51201729996911 0.933333333333333 2.1 2 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 1.33915961572216e-05 4.84891636939601e-05 1.51201729996911 0.933333333333333 2.1 2 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.11383896068658e-10 4.89236984790551e-09 1.50829311942731 0.931034482758621 2.1 2 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.33655328873332e-13 1.46301179220578e-12 1.50430292598967 0.928571428571429 2.1 2 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 1.98480533035849e-09 1.13886209076618e-08 1.50430292598967 0.928571428571429 2.1 2 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 3.28590505819352e-05 0.000109248665836668 1.50430292598967 0.928571428571429 2.1 2 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.84275410484107e-09 2.65047657353417e-08 1.50001716266777 0.925925925925926 2.1 2 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.1783321869138e-08 6.16458346315566e-08 1.49540172524417 0.923076923076923 2.1 2 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 8.02452923769615e-05 0.000251517733595631 1.49540172524417 0.923076923076923 2.1 2 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 8.02452923769615e-05 0.000251517733595631 1.49540172524417 0.923076923076923 2.1 2 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.13356314213016e-11 9.21748772143556e-11 1.48866568143677 0.918918918918919 2.1 2 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 6.91262209918927e-08 3.28985325991516e-07 1.48501699104109 0.916666666666667 2.1 2 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 6.91262209918927e-08 3.28985325991516e-07 1.48501699104109 0.916666666666667 2.1 2 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 6.91262209918927e-08 3.28985325991516e-07 1.48501699104109 0.916666666666667 2.1 2 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 6.91262209918927e-08 3.28985325991516e-07 1.48501699104109 0.916666666666667 2.1 2 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000194901395897179 0.000575403913613456 1.48501699104109 0.916666666666667 2.1 2 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.000194901395897179 0.000575403913613456 1.48501699104109 0.916666666666667 2.1 2 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000194901395897179 0.000575403913613456 1.48501699104109 0.916666666666667 2.1 2 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 2.7375356482045e-11 2.16417401521945e-10 1.48501699104109 0.916666666666667 2.1 2 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.7375356482045e-11 2.16417401521945e-10 1.48501699104109 0.916666666666667 2.1 2 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.5848700422827e-10 9.8915353954749e-10 1.47707572370932 0.911764705882353 2.1 2 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.96781065006354e-48 1.25979939500449e-45 1.47707572370932 0.911764705882353 2.1 2 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.91747027093505e-47 2.72856019554057e-45 1.47622990825386 0.911242603550296 2.1 2 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 3.99911672776104e-07 1.75099787803199e-06 1.47274412334653 0.909090909090909 2.1 2 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 3.99911672776104e-07 1.75099787803199e-06 1.47274412334653 0.909090909090909 2.1 2 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000470384440728644 0.00129455804285633 1.47274412334653 0.909090909090909 2.1 2 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.000470384440728644 0.00129455804285633 1.47274412334653 0.909090909090909 2.1 2 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000470384440728644 0.00129455804285633 1.47274412334653 0.909090909090909 2.1 2 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000470384440728644 0.00129455804285633 1.47274412334653 0.909090909090909 2.1 2 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.000470384440728644 0.00129455804285633 1.47274412334653 0.909090909090909 2.1 2 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.67569759590751e-45 4.75501607179671e-43 1.47093707534243 0.907975460122699 2.1 2 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 2.15454919544854e-12 1.92825377680709e-11 1.4657310560925 0.904761904761905 2.1 2 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 9.56124103523787e-07 3.98992551118577e-06 1.4657310560925 0.904761904761905 2.1 2 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 9.56124103523787e-07 3.98992551118577e-06 1.4657310560925 0.904761904761905 2.1 2 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 9.56124103523787e-07 3.98992551118577e-06 1.4657310560925 0.904761904761905 2.1 2 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 2.16260161819584e-09 1.23095284107707e-08 1.4632425483572 0.903225806451613 2.1 2 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 5.12455829520663e-12 4.3666146431611e-11 1.46196794683424 0.902439024390244 2.1 2 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 5.12455829520663e-12 4.3666146431611e-11 1.46196794683424 0.902439024390244 2.1 2 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 2.27563992407084e-06 9.14755822585537e-06 1.45801668211307 0.9 2.1 2 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.27563992407084e-06 9.14755822585537e-06 1.45801668211307 0.9 2.1 2 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 2.27563992407084e-06 9.14755822585537e-06 1.45801668211307 0.9 2.1 2 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0011267831015335 0.00296928213607809 1.45801668211307 0.9 2.1 2 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0011267831015335 0.00296928213607809 1.45801668211307 0.9 2.1 2 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0011267831015335 0.00296928213607809 1.45801668211307 0.9 2.1 2 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 5.13577393828624e-09 2.78939172296997e-08 1.45801668211307 0.9 2.1 2 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.13577393828624e-09 2.78939172296997e-08 1.45801668211307 0.9 2.1 2 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.21544577608701e-08 6.33545545557441e-08 1.45243041130037 0.896551724137931 2.1 2 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.64989882320506e-13 1.76526768828631e-12 1.45126660488106 0.895833333333333 2.1 2 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.64989882320506e-13 1.76526768828631e-12 1.45126660488106 0.895833333333333 2.1 2 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 5.38933398809096e-06 2.0734840731204e-05 1.44949026876738 0.894736842105263 2.1 2 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 3.88627697134634e-13 3.95012295016132e-12 1.44767613826829 0.893617021276596 2.1 2 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 2.86589938921959e-08 1.44616128753882e-07 1.44644512114392 0.892857142857143 2.1 2 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.92568968351424e-31 4.21612820982038e-29 1.44304172085887 0.890756302521008 2.1 2 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 6.73078639835138e-08 3.24674882876407e-07 1.44001647616105 0.888888888888889 2.1 2 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 1.26934777403914e-05 4.64339815541826e-05 1.44001647616105 0.888888888888889 2.1 2 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00267508246507928 0.00652940368406142 1.44001647616105 0.888888888888889 2.1 2 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00267508246507928 0.00652940368406142 1.44001647616105 0.888888888888889 2.1 2 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00267508246507928 0.00652940368406142 1.44001647616105 0.888888888888889 2.1 2 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00267508246507928 0.00652940368406142 1.44001647616105 0.888888888888889 2.1 2 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00267508246507928 0.00652940368406142 1.44001647616105 0.888888888888889 2.1 2 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00267508246507928 0.00652940368406142 1.44001647616105 0.888888888888889 2.1 2 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 8.75632031967166e-10 5.19176825620532e-09 1.43487356017476 0.885714285714286 2.1 2 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 8.75632031967166e-10 5.19176825620532e-09 1.43487356017476 0.885714285714286 2.1 2 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.57405830851196e-07 7.20220248557082e-07 1.43309332002566 0.884615384615385 2.1 2 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.57405830851196e-07 7.20220248557082e-07 1.43309332002566 0.884615384615385 2.1 2 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 5.48130695455557e-18 1.3928392493451e-16 1.43219029966018 0.884057971014493 2.1 2 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 2.03989627734107e-09 1.16577204925958e-08 1.42942811971869 0.882352941176471 2.1 2 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 2.97148303914391e-05 0.000100916953811498 1.42942811971869 0.882352941176471 2.1 2 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 2.97148303914391e-05 0.000100916953811498 1.42942811971869 0.882352941176471 2.1 2 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 2.97148303914391e-05 0.000100916953811498 1.42942811971869 0.882352941176471 2.1 2 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 2.97148303914391e-05 0.000100916953811498 1.42942811971869 0.882352941176471 2.1 2 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.97148303914391e-05 0.000100916953811498 1.42942811971869 0.882352941176471 2.1 2 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.28413140871496e-71 1.21926379892028e-68 1.42650096315954 0.880546075085324 2.1 2 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 3.66421768497017e-07 1.61429776028252e-06 1.42561631139944 0.88 2.1 2 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.66421768497017e-07 1.61429776028252e-06 1.42561631139944 0.88 2.1 2 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 4.73475851461048e-09 2.60137504489989e-08 1.42365265256832 0.878787878787879 2.1 2 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 6.27982614876282e-11 4.08045324643356e-10 1.4224552996225 0.878048780487805 2.1 2 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 6.27982614876282e-11 4.08045324643356e-10 1.4224552996225 0.878048780487805 2.1 2 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 6.27982614876282e-11 4.08045324643356e-10 1.4224552996225 0.878048780487805 2.1 2 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 6.27982614876282e-11 4.08045324643356e-10 1.4224552996225 0.878048780487805 2.1 2 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 6.27982614876282e-11 4.08045324643356e-10 1.4224552996225 0.878048780487805 2.1 2 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 6.27982614876282e-11 4.08045324643356e-10 1.4224552996225 0.878048780487805 2.1 2 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 9.64076561432849e-32 7.62156081621636e-30 1.42063163898196 0.876923076923077 2.1 2 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 6.99332966992519e-20 2.21144624895634e-18 1.41751621872104 0.875 2.1 2 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.45039278325147e-10 9.09210982628567e-10 1.41751621872104 0.875 2.1 2 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.09469165651209e-08 5.769430471173e-08 1.41751621872104 0.875 2.1 2 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 8.48759473906236e-07 3.59459741478742e-06 1.41751621872104 0.875 2.1 2 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 6.90873236153454e-05 0.000217502790939461 1.41751621872104 0.875 2.1 2 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 6.90873236153454e-05 0.000217502790939461 1.41751621872104 0.875 2.1 2 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 6.90873236153454e-05 0.000217502790939461 1.41751621872104 0.875 2.1 2 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00628191847566784 0.0136475877723287 1.41751621872104 0.875 2.1 2 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.6624636228394e-61 3.37955105042923e-59 1.41518860588242 0.873563218390805 2.1 2 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 8.41316118416883e-16 1.6178281574422e-14 1.41430189622961 0.873015873015873 2.1 2 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.27580153054097e-98 6.05155192653267e-96 1.41086121299934 0.870892018779343 2.1 2 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.40665925298947e-13 1.52799703588093e-12 1.4100161329077 0.87037037037037 2.1 2 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.95545364057555e-06 7.95664828064153e-06 1.40871177015755 0.869565217391304 2.1 2 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.0119351556097e-14 1.30907611493874e-13 1.40401606425703 0.866666666666667 2.1 2 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.0119351556097e-14 1.30907611493874e-13 1.40401606425703 0.866666666666667 2.1 2 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.0119351556097e-14 1.30907611493874e-13 1.40401606425703 0.866666666666667 2.1 2 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.0119351556097e-14 1.30907611493874e-13 1.40401606425703 0.866666666666667 2.1 2 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.0119351556097e-14 1.30907611493874e-13 1.40401606425703 0.866666666666667 2.1 2 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.0119351556097e-14 1.30907611493874e-13 1.40401606425703 0.866666666666667 2.1 2 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.0119351556097e-14 1.30907611493874e-13 1.40401606425703 0.866666666666667 2.1 2 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000159397504342573 0.00047852879468245 1.40401606425703 0.866666666666667 2.1 2 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000159397504342573 0.00047852879468245 1.40401606425703 0.866666666666667 2.1 2 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.000159397504342573 0.00047852879468245 1.40401606425703 0.866666666666667 2.1 2 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000159397504342573 0.00047852879468245 1.40401606425703 0.866666666666667 2.1 2 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.27265272850587e-29 7.54577013609937e-28 1.40316566082622 0.866141732283465 2.1 2 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 7.35363455388804e-13 7.21670480702254e-12 1.40193911741641 0.865384615384615 2.1 2 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 9.30429786844648e-31 6.01818903036334e-29 1.400767906792 0.864661654135338 2.1 2 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.30727083778074e-14 2.69118557554262e-13 1.40035500541933 0.864406779661017 2.1 2 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.30727083778074e-14 2.69118557554262e-13 1.40035500541933 0.864406779661017 2.1 2 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 4.47880283159248e-06 1.74134875119019e-05 1.39910691717921 0.863636363636364 2.1 2 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 4.47880283159248e-06 1.74134875119019e-05 1.39910691717921 0.863636363636364 2.1 2 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 4.47880283159248e-06 1.74134875119019e-05 1.39910691717921 0.863636363636364 2.1 2 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.83248519701033e-116 2.60762643534569e-113 1.39518706590034 0.861216730038023 2.1 2 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 3.98223767545558e-09 2.21356414538019e-08 1.39501596128102 0.861111111111111 2.1 2 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.800199721357e-12 3.33807666882161e-11 1.39321594068582 0.86 2.1 2 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.72286549469491e-24 7.90850838371242e-23 1.39291313348289 0.85981308411215 2.1 2 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.7092005227503e-19 7.55920067426212e-18 1.38858731629816 0.857142857142857 2.1 2 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.7092005227503e-19 7.55920067426212e-18 1.38858731629816 0.857142857142857 2.1 2 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 9.02548174958448e-09 4.7922613916637e-08 1.38858731629816 0.857142857142857 2.1 2 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 1.01927348473531e-05 3.77715148119361e-05 1.38858731629816 0.857142857142857 2.1 2 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 1.01927348473531e-05 3.77715148119361e-05 1.38858731629816 0.857142857142857 2.1 2 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.01927348473531e-05 3.77715148119361e-05 1.38858731629816 0.857142857142857 2.1 2 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 2.99201084531421e-07 1.33050982277566e-06 1.38858731629816 0.857142857142857 2.1 2 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00036456274314712 0.00103135742246193 1.38858731629816 0.857142857142857 2.1 2 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00036456274314712 0.00103135742246193 1.38858731629816 0.857142857142857 2.1 2 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.00036456274314712 0.00103135742246193 1.38858731629816 0.857142857142857 2.1 2 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00036456274314712 0.00103135742246193 1.38858731629816 0.857142857142857 2.1 2 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00036456274314712 0.00103135742246193 1.38858731629816 0.857142857142857 2.1 2 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00036456274314712 0.00103135742246193 1.38858731629816 0.857142857142857 2.1 2 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.00036456274314712 0.00103135742246193 1.38858731629816 0.857142857142857 2.1 2 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.00036456274314712 0.00103135742246193 1.38858731629816 0.857142857142857 2.1 2 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0145525311219537 0.0289625899112449 1.38858731629816 0.857142857142857 2.1 2 1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0145525311219537 0.0289625899112449 1.38858731629816 0.857142857142857 2.1 2 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0145525311219537 0.0289625899112449 1.38858731629816 0.857142857142857 2.1 2 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0145525311219537 0.0289625899112449 1.38858731629816 0.857142857142857 2.1 2 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0145525311219537 0.0289625899112449 1.38858731629816 0.857142857142857 2.1 2 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0145525311219537 0.0289625899112449 1.38858731629816 0.857142857142857 2.1 2 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.43575088234471e-24 6.8102450185884e-23 1.38437947594574 0.854545454545454 2.1 2 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.37613262369921e-18 3.62636430282218e-17 1.38294265241077 0.853658536585366 2.1 2 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 6.75469140340378e-07 2.89515839368782e-06 1.38001578965434 0.851851851851852 2.1 2 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.35949319989182e-11 2.95946299275458e-10 1.37873917930314 0.851063829787234 2.1 2 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.05502528530513e-15 5.41746146151648e-14 1.37822472438549 0.850746268656716 2.1 2 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.21392710413625e-19 6.42942503915486e-18 1.37794680046446 0.850574712643678 2.1 2 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.21392710413625e-19 6.42942503915486e-18 1.37794680046446 0.850574712643678 2.1 2 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.40378832984916e-09 8.22053824434305e-09 1.37701575532901 0.85 2.1 2 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 2.30336003508716e-05 8.15343614410206e-05 1.37701575532901 0.85 2.1 2 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.08168745695748e-22 1.85416442339756e-20 1.37701575532901 0.85 2.1 2 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.17485377833708e-16 4.68911655541464e-15 1.37590615359224 0.849315068493151 2.1 2 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.17485377833708e-16 4.68911655541464e-15 1.37590615359224 0.849315068493151 2.1 2 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 9.76449019553757e-11 6.25895024695945e-10 1.37349397590361 0.847826086956522 2.1 2 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 4.86131726895467e-16 9.57738752642042e-15 1.372515703841 0.847222222222222 2.1 2 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.86131726895467e-16 9.57738752642042e-15 1.372515703841 0.847222222222222 2.1 2 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 1.51600942554902e-06 6.23491737733023e-06 1.37078491480716 0.846153846153846 2.1 2 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000825509965258376 0.00220394123932959 1.37078491480716 0.846153846153846 2.1 2 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.000825509965258376 0.00220394123932959 1.37078491480716 0.846153846153846 2.1 2 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000825509965258376 0.00220394123932959 1.37078491480716 0.846153846153846 2.1 2 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000825509965258376 0.00220394123932959 1.37078491480716 0.846153846153846 2.1 2 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000825509965258376 0.00220394123932959 1.37078491480716 0.846153846153846 2.1 2 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.000825509965258376 0.00220394123932959 1.37078491480716 0.846153846153846 2.1 2 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.90679147334716e-23 1.25344371714334e-21 1.36735509433641 0.844036697247706 2.1 2 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.5227488013965e-11 1.23117701385638e-10 1.36589798106453 0.843137254901961 2.1 2 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.41089060777141e-15 4.34265485425155e-14 1.36544419435986 0.842857142857143 2.1 2 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 6.99751572523414e-09 3.74340784849931e-08 1.36422613531047 0.842105263157895 2.1 2 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 5.16489110859937e-05 0.000167847571472909 1.36422613531047 0.842105263157895 2.1 2 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 5.16489110859937e-05 0.000167847571472909 1.36422613531047 0.842105263157895 2.1 2 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.55241082712826e-14 8.46226819449096e-13 1.36287273636671 0.841269841269841 2.1 2 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 5.34826273510281e-15 7.68745239601141e-14 1.3617547111523 0.840579710144927 2.1 2 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.38103242730463e-06 1.33274491525055e-05 1.3608155699722 0.84 2.1 2 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.38103242730463e-06 1.33274491525055e-05 1.3608155699722 0.84 2.1 2 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 3.79751833707222e-16 7.71981227664825e-15 1.3608155699722 0.84 2.1 2 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.55170512288544e-08 7.97139490926345e-08 1.35731282719235 0.837837837837838 2.1 2 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.55170512288544e-08 7.97139490926345e-08 1.35731282719235 0.837837837837838 2.1 2 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.69158831251838e-13 3.77923033720406e-12 1.35444172655312 0.836065573770492 2.1 2 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.69158831251838e-13 3.77923033720406e-12 1.35444172655312 0.836065573770492 2.1 2 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.69158831251838e-13 3.77923033720406e-12 1.35444172655312 0.836065573770492 2.1 2 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.61070449309873e-14 2.9720259949436e-13 1.35404534325592 0.835820895522388 2.1 2 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.61070449309873e-14 2.9720259949436e-13 1.35404534325592 0.835820895522388 2.1 2 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.61070449309873e-14 2.9720259949436e-13 1.35404534325592 0.835820895522388 2.1 2 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.3165149529217e-16 3.07114881640588e-15 1.35343320702479 0.835443037974684 2.1 2 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 4.07310661771607e-15 6.98316953856623e-14 1.35001544640099 0.833333333333333 2.1 2 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 5.01994555239561e-07 2.17124088785986e-06 1.35001544640099 0.833333333333333 2.1 2 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 5.01994555239561e-07 2.17124088785986e-06 1.35001544640099 0.833333333333333 2.1 2 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 7.48892447392214e-06 2.82672135978547e-05 1.35001544640099 0.833333333333333 2.1 2 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000114821593646677 0.000350001137502829 1.35001544640099 0.833333333333333 2.1 2 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000114821593646677 0.000350001137502829 1.35001544640099 0.833333333333333 2.1 2 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000114821593646677 0.000350001137502829 1.35001544640099 0.833333333333333 2.1 2 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000114821593646677 0.000350001137502829 1.35001544640099 0.833333333333333 2.1 2 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00184779966488597 0.00462112288775524 1.35001544640099 0.833333333333333 2.1 2 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 48%5605140 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.0331294366168651 0.0617866163903001 1.35001544640099 0.833333333333333 2.1 2 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 8.93496179210019e-15 1.23441268253967e-13 1.34621258598859 0.830985915492958 2.1 2 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.60971342980181e-20 1.16741413877454e-18 1.34461538461538 0.83 2.1 2 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.38981512093525e-15 2.60224594354061e-14 1.34291010194625 0.828947368421053 2.1 2 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 7.51724352398521e-08 3.5420654088182e-07 1.34230107242155 0.828571428571429 2.1 2 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 2.7554559219238e-13 2.90445464955376e-12 1.34157784986098 0.828125 2.1 2 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 3.89641099479179e-12 3.38084929609068e-11 1.3407049950465 0.827586206896552 2.1 2 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 3.89641099479179e-12 3.38084929609068e-11 1.3407049950465 0.827586206896552 2.1 2 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 5.53117781135515e-11 3.69524226552037e-10 1.3396307121979 0.826923076923077 2.1 2 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.72098124842692e-19 5.2105453542798e-18 1.33899491214465 0.826530612244898 2.1 2 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 7.89096203322636e-10 4.79864913388081e-09 1.33827618164968 0.826086956521739 2.1 2 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 7.89096203322636e-10 4.79864913388081e-09 1.33827618164968 0.826086956521739 2.1 2 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 1.64647114889229e-05 5.87200111497174e-05 1.33827618164968 0.826086956521739 2.1 2 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.64647114889229e-05 5.87200111497174e-05 1.33827618164968 0.826086956521739 2.1 2 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.13309261956265e-08 5.94978154109833e-08 1.33651529193698 0.825 2.1 2 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 6.60085475095173e-15 9.30001614911318e-14 1.33542068481828 0.824324324324324 2.1 2 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 6.60085475095173e-15 9.30001614911318e-14 1.33542068481828 0.824324324324324 2.1 2 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 1.64128531714943e-07 7.46181791151322e-07 1.33413291173745 0.823529411764706 2.1 2 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 1.64128531714943e-07 7.46181791151322e-07 1.33413291173745 0.823529411764706 2.1 2 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000252825625326908 0.000734226254775899 1.33413291173745 0.823529411764706 2.1 2 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000252825625326908 0.000734226254775899 1.33413291173745 0.823529411764706 2.1 2 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.20432443735589e-10 7.68499405541451e-10 1.33413291173745 0.823529411764706 2.1 2 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.30539752593586e-12 1.22639430412633e-11 1.33259589225388 0.82258064516129 2.1 2 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.71674693207198e-09 9.89040843861712e-09 1.33201524044898 0.822222222222222 2.1 2 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.71674693207198e-09 9.89040843861712e-09 1.33201524044898 0.822222222222222 2.1 2 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.84311615266235e-11 1.47345746361715e-10 1.3307295114524 0.821428571428571 2.1 2 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 8.47746712632636e-39 8.61673980054457e-37 1.32687232446269 0.819047619047619 2.1 2 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.98661879376149e-11 2.95946299275458e-10 1.32546971101188 0.818181818181818 2.1 2 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.98661879376149e-11 2.95946299275458e-10 1.32546971101188 0.818181818181818 2.1 2 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.98661879376149e-11 2.95946299275458e-10 1.32546971101188 0.818181818181818 2.1 2 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.98661879376149e-11 2.95946299275458e-10 1.32546971101188 0.818181818181818 2.1 2 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 3.98661879376149e-11 2.95946299275458e-10 1.32546971101188 0.818181818181818 2.1 2 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.98661879376149e-11 2.95946299275458e-10 1.32546971101188 0.818181818181818 2.1 2 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.98661879376149e-11 2.95946299275458e-10 1.32546971101188 0.818181818181818 2.1 2 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.71804034466676e-09 2.08298087026016e-08 1.32546971101188 0.818181818181818 2.1 2 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00408057707515535 0.00939589187369914 1.32546971101188 0.818181818181818 2.1 2 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 6.1018810544965e-12 5.13785605949616e-11 1.32301513747297 0.816666666666667 2.1 2 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 5.32464227448871e-08 2.61274688158532e-07 1.32159406858202 0.815789473684211 2.1 2 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 8.58973423761596e-11 5.53085602720702e-10 1.32001510314763 0.814814814814815 2.1 2 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 5.33319759359296e-23 2.05111896640075e-21 1.31953122664355 0.814516129032258 2.1 2 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 5.33319759359296e-23 2.05111896640075e-21 1.31953122664355 0.814516129032258 2.1 2 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 5.33319759359296e-23 2.05111896640075e-21 1.31953122664355 0.814516129032258 2.1 2 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000550741620827227 0.00150135120007116 1.31626506024096 0.8125 2.1 2 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.000550741620827227 0.00150135120007116 1.31626506024096 0.8125 2.1 2 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.000550741620827227 0.00150135120007116 1.31626506024096 0.8125 2.1 2 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.08478188593992e-13 3.22767987036214e-12 1.31479765214705 0.811594202898551 2.1 2 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.84336518745747e-10 1.14546229770829e-09 1.31435466102436 0.811320754716981 2.1 2 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.81149522206126e-11 2.19821851702922e-10 1.31277364098303 0.810344827586207 2.1 2 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.81149522206126e-11 2.19821851702922e-10 1.31277364098303 0.810344827586207 2.1 2 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.15060260036358e-18 1.0738740909668e-16 1.30910588741914 0.808080808080808 2.1 2 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.12141290346782e-05 4.12343814375893e-05 1.30847650958865 0.807692307692308 2.1 2 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 1.12141290346782e-05 4.12343814375893e-05 1.30847650958865 0.807692307692308 2.1 2 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.40068567991604e-15 4.34265485425155e-14 1.30772580591132 0.807228915662651 2.1 2 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 7.32356889909398e-39 8.01649118723903e-37 1.30763827992203 0.807174887892377 2.1 2 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.53851452491821e-20 5.0914096952526e-19 1.30738337967254 0.807017543859649 2.1 2 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.40430224419434e-12 1.29761174901854e-11 1.30568658099678 0.805970149253731 2.1 2 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 2.4474261530686e-07 1.09518472195491e-06 1.30501493152096 0.805555555555556 2.1 2 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.66723523810935e-08 1.82464186847189e-07 1.3039173579873 0.804878048780488 2.1 2 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.38220906413539e-10 5.01171575557339e-09 1.30236784241037 0.803921568627451 2.1 2 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.38220906413539e-10 5.01171575557339e-09 1.30236784241037 0.803921568627451 2.1 2 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 4.57295853101677e-13 4.55057341932648e-12 1.30057826103983 0.802816901408451 2.1 2 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000166110154026483 0.0004976310509046 1.29601482854495 0.8 2.1 2 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.00886827991926238 0.0183423871004511 1.29601482854495 0.8 2.1 2 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 2.39204926603921e-05 8.36335652475135e-05 1.29601482854495 0.8 2.1 2 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 2.39204926603921e-05 8.36335652475135e-05 1.29601482854495 0.8 2.1 2 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 2.39204926603921e-05 8.36335652475135e-05 1.29601482854495 0.8 2.1 2 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 2.39204926603921e-05 8.36335652475135e-05 1.29601482854495 0.8 2.1 2 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00118522369836531 0.0030833150324933 1.29601482854495 0.8 2.1 2 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00118522369836531 0.0030833150324933 1.29601482854495 0.8 2.1 2 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.37545409426799e-18 3.62636430282218e-17 1.29001475989428 0.796296296296296 2.1 2 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 5.69144208190494e-10 3.49091469075463e-09 1.29001475989428 0.796296296296296 2.1 2 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 3.74306742342158e-09 2.08877840922702e-08 1.28940250799115 0.795918367346939 2.1 2 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 7.40357031576782e-06 2.80193631897277e-05 1.28484228691956 0.793103448275862 2.1 2 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 7.40357031576782e-06 2.80193631897277e-05 1.28484228691956 0.793103448275862 2.1 2 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 9.35659918282247e-19 2.5604693532993e-17 1.28433901927878 0.792792792792793 2.1 2 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.19424053619369e-09 7.02233174794884e-09 1.28378827355868 0.792452830188679 2.1 2 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 5.05727021459258e-05 0.000165436678514143 1.28251467408094 0.791666666666667 2.1 2 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.05350072180482e-14 1.3385102920788e-13 1.28094488867815 0.790697674418605 2.1 2 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.05350072180482e-14 1.3385102920788e-13 1.28094488867815 0.790697674418605 2.1 2 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 5.1846823349884e-08 2.55287299747007e-07 1.28094488867815 0.790697674418605 2.1 2 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 5.1846823349884e-08 2.55287299747007e-07 1.28094488867815 0.790697674418605 2.1 2 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 3.44154392923593e-07 1.52564392875475e-06 1.27896200185357 0.789473684210526 2.1 2 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.4941798472936e-09 1.40841981059476e-08 1.2773223069794 0.788461538461538 2.1 2 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.4941798472936e-09 1.40841981059476e-08 1.2773223069794 0.788461538461538 2.1 2 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.19432567757145e-14 2.60210453265348e-13 1.2769557869487 0.788235294117647 2.1 2 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.19432567757145e-14 2.60210453265348e-13 1.2769557869487 0.788235294117647 2.1 2 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.19432567757145e-14 2.60210453265348e-13 1.2769557869487 0.788235294117647 2.1 2 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.19432567757145e-14 2.60210453265348e-13 1.2769557869487 0.788235294117647 2.1 2 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 2.30006988039161e-06 9.21971673182327e-06 1.27637824023366 0.787878787878788 2.1 2 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 9.69936542410432e-26 4.92935607089302e-24 1.27576459684893 0.7875 2.1 2 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.63876778967426e-08 8.35830309930635e-08 1.2753337408554 0.787234042553192 2.1 2 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.80150893724486e-29 2.14278621495813e-27 1.2747686838147 0.786885245901639 2.1 2 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 9.19564566576175e-13 8.72360252158598e-12 1.27441458140253 0.786666666666667 2.1 2 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 9.19564566576175e-13 8.72360252158598e-12 1.27441458140253 0.786666666666667 2.1 2 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 9.19564566576175e-13 8.72360252158598e-12 1.27441458140253 0.786666666666667 2.1 2 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 9.19564566576175e-13 8.72360252158598e-12 1.27441458140253 0.786666666666667 2.1 2 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 9.19564566576175e-13 8.72360252158598e-12 1.27441458140253 0.786666666666667 2.1 2 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.55106964529541e-05 5.57366693246304e-05 1.27287170660665 0.785714285714286 2.1 2 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00251564977966631 0.00621485765454795 1.27287170660665 0.785714285714286 2.1 2 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00251564977966631 0.00621485765454795 1.27287170660665 0.785714285714286 2.1 2 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00251564977966631 0.00621485765454795 1.27287170660665 0.785714285714286 2.1 2 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.51814713021528e-10 1.55796668099841e-09 1.26901451961693 0.783333333333333 2.1 2 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000105892011663946 0.000326156564064493 1.2678405931418 0.782608695652174 2.1 2 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.93557900601135e-12 3.39413874276009e-11 1.26494597991545 0.780821917808219 2.1 2 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.07190047485756e-08 5.67031366439519e-08 1.26361445783133 0.78 2.1 2 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.09167384861406e-15 5.41746146151648e-14 1.26190917516219 0.778947368421053 2.1 2 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.54163475983902e-16 3.42772853632957e-15 1.26174520567477 0.778846153846154 2.1 2 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.98624127916217e-14 2.43657012090325e-13 1.26001441664092 0.777777777777778 2.1 2 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 4.00162976651893e-13 4.01008391391298e-12 1.26001441664092 0.777777777777778 2.1 2 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 4.00162976651893e-13 4.01008391391298e-12 1.26001441664092 0.777777777777778 2.1 2 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 8.09709931062131e-12 6.77774842294949e-11 1.26001441664092 0.777777777777778 2.1 2 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 7.02146676985811e-08 3.33051573783603e-07 1.26001441664092 0.777777777777778 2.1 2 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 3.2213227274417e-05 0.000107352277310294 1.26001441664092 0.777777777777778 2.1 2 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 3.2213227274417e-05 0.000107352277310294 1.26001441664092 0.777777777777778 2.1 2 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 3.2213227274417e-05 0.000107352277310294 1.26001441664092 0.777777777777778 2.1 2 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 3.2213227274417e-05 0.000107352277310294 1.26001441664092 0.777777777777778 2.1 2 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 3.2213227274417e-05 0.000107352277310294 1.26001441664092 0.777777777777778 2.1 2 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 3.2213227274417e-05 0.000107352277310294 1.26001441664092 0.777777777777778 2.1 2 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000735839736207719 0.00198690691579428 1.26001441664092 0.777777777777778 2.1 2 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.000735839736207719 0.00198690691579428 1.26001441664092 0.777777777777778 2.1 2 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000735839736207719 0.00198690691579428 1.26001441664092 0.777777777777778 2.1 2 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0189058445127278 0.0372617960410135 1.26001441664092 0.777777777777778 2.1 2 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0189058445127278 0.0372617960410135 1.26001441664092 0.777777777777778 2.1 2 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0189058445127278 0.0372617960410135 1.26001441664092 0.777777777777778 2.1 2 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0189058445127278 0.0372617960410135 1.26001441664092 0.777777777777778 2.1 2 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0189058445127278 0.0372617960410135 1.26001441664092 0.777777777777778 2.1 2 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 4.61519641802968e-07 2.00838669812117e-06 1.25551436515292 0.775 2.1 2 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.2983745208361e-14 1.63503269305289e-13 1.25420789859189 0.774193548387097 2.1 2 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 8.31500746908961e-14 9.24394970977697e-13 1.25183250484455 0.772727272727273 2.1 2 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.000219393568137495 0.000643705252494135 1.25183250484455 0.772727272727273 2.1 2 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.67472961050182e-12 1.51792371703445e-11 1.25090038831079 0.772151898734177 2.1 2 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 9.08667745709997e-31 6.01818903036334e-29 1.24972858466834 0.771428571428571 2.1 2 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 3.04631363058322e-06 1.21425890653219e-05 1.24972858466834 0.771428571428571 2.1 2 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.69307772506249e-13 1.7979474647492e-12 1.2476004815016 0.770114942528736 2.1 2 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.10314228809551e-20 3.8287109169754e-19 1.24706462818624 0.76978417266187 2.1 2 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 6.62750380794386e-05 0.000211456007145832 1.24616810437014 0.769230769230769 2.1 2 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 6.62750380794386e-05 0.000211456007145832 1.24616810437014 0.769230769230769 2.1 2 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 6.62750380794386e-05 0.000211456007145832 1.24616810437014 0.769230769230769 2.1 2 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00525543199697792 0.0116851245807806 1.24616810437014 0.769230769230769 2.1 2 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00525543199697792 0.0116851245807806 1.24616810437014 0.769230769230769 2.1 2 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.71410473093995e-14 2.12101828880657e-13 1.24485634847081 0.768421052631579 2.1 2 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.71410473093995e-14 2.12101828880657e-13 1.24485634847081 0.768421052631579 2.1 2 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.22462695266259e-31 9.17181133494137e-30 1.24446878422782 0.768181818181818 2.1 2 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 2.02119856363116e-05 7.17248268340931e-05 1.24201421068891 0.766666666666667 2.1 2 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 4.41699323936373e-10 2.72094432017947e-09 1.24032669138091 0.765625 2.1 2 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 6.20872490835266e-06 2.36230362154702e-05 1.2388377037562 0.764705882352941 2.1 2 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00151896860620326 0.00388757612702741 1.2388377037562 0.764705882352941 2.1 2 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00151896860620326 0.00388757612702741 1.2388377037562 0.764705882352941 2.1 2 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.40903833073767e-11 2.95946299275458e-10 1.23751415920091 0.763888888888889 2.1 2 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 5.95198744935462e-07 2.56656913346413e-06 1.23429983670948 0.761904761904762 2.1 2 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000449319354940584 0.00125002635357679 1.23429983670948 0.761904761904762 2.1 2 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000449319354940584 0.00125002635357679 1.23429983670948 0.761904761904762 2.1 2 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 4.51918127659752e-15 7.6557082816646e-14 1.23059100306552 0.759615384615385 2.1 2 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 8.88042022802541e-12 7.34699882818614e-11 1.23039382456799 0.759493670886076 2.1 2 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 8.88042022802541e-12 7.34699882818614e-11 1.23039382456799 0.759493670886076 2.1 2 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 1.25506485039797e-05 4.60298268586679e-05 1.22728676945544 0.757575757575758 2.1 2 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.25815236352737e-114 3.02967540664973e-111 1.21867910206786 0.752262443438914 2.1 2 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 7.04058653209529e-11 4.55397937962345e-10 1.21501390176089 0.75 2.1 2 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000908546150917515 0.00241205442678288 1.21501390176089 0.75 2.1 2 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000908546150917515 0.00241205442678288 1.21501390176089 0.75 2.1 2 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.2852991711445e-15 4.22335158511509e-14 1.21501390176089 0.75 2.1 2 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 7.23869609096883e-08 3.42214768686002e-07 1.21501390176089 0.75 2.1 2 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 7.42951012795253e-07 3.16532721918456e-06 1.21501390176089 0.75 2.1 2 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 7.42951012795253e-07 3.16532721918456e-06 1.21501390176089 0.75 2.1 2 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 8.23208197388061e-05 0.000257456102172134 1.21501390176089 0.75 2.1 2 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000271849940218008 0.000787866527352802 1.21501390176089 0.75 2.1 2 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00308866993097956 0.00735133782085786 1.21501390176089 0.75 2.1 2 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00308866993097956 0.00735133782085786 1.21501390176089 0.75 2.1 2 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00308866993097956 0.00735133782085786 1.21501390176089 0.75 2.1 2 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00308866993097956 0.00735133782085786 1.21501390176089 0.75 2.1 2 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00308866993097956 0.00735133782085786 1.21501390176089 0.75 2.1 2 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00308866993097956 0.00735133782085786 1.21501390176089 0.75 2.1 2 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0107789093059635 0.022133315934179 1.21501390176089 0.75 2.1 2 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0107789093059635 0.022133315934179 1.21501390176089 0.75 2.1 2 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0107789093059635 0.022133315934179 1.21501390176089 0.75 2.1 2 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0107789093059635 0.022133315934179 1.21501390176089 0.75 2.1 2 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0393643690608112 0.0721176373294332 1.21501390176089 0.75 2.1 2 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0393643690608112 0.0721176373294332 1.21501390176089 0.75 2.1 2 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0393643690608112 0.0721176373294332 1.21501390176089 0.75 2.1 2 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0393643690608112 0.0721176373294332 1.21501390176089 0.75 2.1 2 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0393643690608112 0.0721176373294332 1.21501390176089 0.75 2.1 2 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0393643690608112 0.0721176373294332 1.21501390176089 0.75 2.1 2 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0393643690608112 0.0721176373294332 1.21501390176089 0.75 2.1 2 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.45332573680793e-16 3.28267067218681e-15 1.21172118115991 0.747967479674797 2.1 2 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.40967944023717e-08 7.29445033984543e-08 1.20814941644021 0.745762711864407 2.1 2 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 8.90597396986655e-15 1.23441268253967e-13 1.20765018114416 0.745454545454545 2.1 2 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.32064641102746e-20 2.26462605280263e-18 1.20194923615056 0.741935483870968 2.1 2 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 8.727791160755e-09 4.65155311676194e-08 1.20194923615056 0.741935483870968 2.1 2 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.70626493772074e-11 1.37175989060826e-10 1.2007196205637 0.741176470588235 2.1 2 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.94446079264608e-22 1.10262308103562e-20 1.19899676934596 0.740112994350282 2.1 2 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 9.0213119497935e-07 3.79802571140714e-06 1.19740500463392 0.739130434782609 2.1 2 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 9.0213119497935e-07 3.79802571140714e-06 1.19740500463392 0.739130434782609 2.1 2 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.38680871940864e-09 2.90357151807519e-08 1.19632138019534 0.738461538461539 2.1 2 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 5.38680871940864e-09 2.90357151807519e-08 1.19632138019534 0.738461538461539 2.1 2 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00181137736849145 0.00461107333696482 1.19369786839666 0.736842105263158 2.1 2 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00181137736849145 0.00461107333696482 1.19369786839666 0.736842105263158 2.1 2 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.65543249505659e-16 5.47634846444279e-15 1.1930369061218 0.736434108527132 2.1 2 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.0167102936277e-05 0.000102209017805529 1.19119009976558 0.735294117647059 2.1 2 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00617432150324407 0.0136429495327893 1.18801359283287 0.733333333333333 2.1 2 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00617432150324407 0.0136429495327893 1.18801359283287 0.733333333333333 2.1 2 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00617432150324407 0.0136429495327893 1.18801359283287 0.733333333333333 2.1 2 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.18897175048249e-61 2.81984466822763e-59 1.18619334728716 0.732209737827715 2.1 2 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000321432825703856 0.000924038203993105 1.18385969915164 0.730769230769231 2.1 2 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 1.81806703059916e-05 6.46777346135653e-05 1.18217568819978 0.72972972972973 2.1 2 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0216354875035477 0.0417172069343474 1.17819529867723 0.727272727272727 2.1 2 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0216354875035477 0.0417172069343474 1.17819529867723 0.727272727272727 2.1 2 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0216354875035477 0.0417172069343474 1.17819529867723 0.727272727272727 2.1 2 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.09372941089687e-05 4.04253753689934e-05 1.17451343836886 0.725 2.1 2 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.91513995705632e-29 2.14278621495813e-27 1.17139801810793 0.723076923076923 2.1 2 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 3.51276992112267e-05 0.000115978459344723 1.17001338688086 0.722222222222222 2.1 2 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 3.51276992112267e-05 0.000115978459344723 1.17001338688086 0.722222222222222 2.1 2 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00355510366819167 0.00843152086639458 1.17001338688086 0.722222222222222 2.1 2 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.000623823418021163 0.00169732451977842 1.16641334569045 0.72 2.1 2 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.12179789068413e-15 5.41746146151648e-14 1.16592243098267 0.71969696969697 2.1 2 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.3201836575175e-20 4.47290796344618e-19 1.16086889722609 0.716577540106952 2.1 2 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.63957748330507e-08 4.0176858688703e-07 1.15715609691513 0.714285714285714 2.1 2 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.50704232125277e-07 1.96733779851003e-06 1.15715609691513 0.714285714285714 2.1 2 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000366778691981241 0.00103556761644704 1.15715609691513 0.714285714285714 2.1 2 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.012104887540257 0.0246427109725117 1.15715609691513 0.714285714285714 2.1 2 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.012104887540257 0.0246427109725117 1.15715609691513 0.714285714285714 2.1 2 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.012104887540257 0.0246427109725117 1.15715609691513 0.714285714285714 2.1 2 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.012104887540257 0.0246427109725117 1.15715609691513 0.714285714285714 2.1 2 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.012104887540257 0.0246427109725117 1.15715609691513 0.714285714285714 2.1 2 1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0795717003541435 0.131053853708271 1.15715609691513 0.714285714285714 2.1 2 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0795717003541435 0.131053853708271 1.15715609691513 0.714285714285714 2.1 2 1 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0795717003541435 0.131053853708271 1.15715609691513 0.714285714285714 2.1 2 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0795717003541435 0.131053853708271 1.15715609691513 0.714285714285714 2.1 2 1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0795717003541435 0.131053853708271 1.15715609691513 0.714285714285714 2.1 2 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0795717003541435 0.131053853708271 1.15715609691513 0.714285714285714 2.1 2 1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0795717003541435 0.131053853708271 1.15715609691513 0.714285714285714 2.1 2 1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0795717003541435 0.131053853708271 1.15715609691513 0.714285714285714 2.1 2 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000215960074554723 0.000634940467130932 1.14969057370923 0.709677419354839 2.1 2 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000215960074554723 0.000634940467130932 1.14969057370923 0.709677419354839 2.1 2 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.48559660645223e-17 6.09828270858882e-16 1.14586676914035 0.707317073170732 2.1 2 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.37144859036737e-05 8.36335652475135e-05 1.14586676914035 0.707317073170732 2.1 2 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00685595311044267 0.0148042811474354 1.14354249577496 0.705882352941177 2.1 2 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00685595311044267 0.0148042811474354 1.14354249577496 0.705882352941177 2.1 2 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00685595311044267 0.0148042811474354 1.14354249577496 0.705882352941177 2.1 2 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00685595311044267 0.0148042811474354 1.14354249577496 0.705882352941177 2.1 2 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 6.85659331981797e-09 3.68186124305697e-08 1.1423207623393 0.705128205128205 2.1 2 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.85345786408593e-21 6.59367635148571e-20 1.14172734895626 0.704761904761905 2.1 2 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.40958281046432e-05 5.07806668174869e-05 1.14137669559356 0.704545454545455 2.1 2 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.42637871682473e-16 3.27376921619612e-15 1.14114513205216 0.70440251572327 2.1 2 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000696298855134912 0.00189090318865836 1.1400130436275 0.703703703703704 2.1 2 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.6507847057392e-16 5.47634846444279e-15 1.13811428772539 0.70253164556962 2.1 2 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.91320653147358e-16 9.57738752642042e-15 1.13504483391675 0.700636942675159 2.1 2 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00391798354283066 0.00923061354544376 1.13401297497683 0.7 2.1 2 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00391798354283066 0.00923061354544376 1.13401297497683 0.7 2.1 2 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0423268285641473 0.0766298690162615 1.13401297497683 0.7 2.1 2 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0423268285641473 0.0766298690162615 1.13401297497683 0.7 2.1 2 1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0423268285641473 0.0766298690162615 1.13401297497683 0.7 2.1 2 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0423268285641473 0.0766298690162615 1.13401297497683 0.7 2.1 2 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 9.0821681183846e-16 1.72319003099484e-14 1.13193602813621 0.698717948717949 2.1 2 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 2.63060563225885e-05 9.04191259590421e-05 1.13024549001013 0.697674418604651 2.1 2 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.63060563225885e-05 9.04191259590421e-05 1.13024549001013 0.697674418604651 2.1 2 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000238601984185248 0.000695759474376246 1.12910382789901 0.696969696969697 2.1 2 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000238601984185248 0.000695759474376246 1.12910382789901 0.696969696969697 2.1 2 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.64871367607873e-12 1.5039227955513e-11 1.12870143879427 0.69672131147541 2.1 2 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.55859622207425e-05 5.58660560204448e-05 1.12696941612604 0.695652173913043 2.1 2 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0013042022507351 0.00337432691417462 1.12155129393313 0.692307692307692 2.1 2 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0013042022507351 0.00337432691417462 1.12155129393313 0.692307692307692 2.1 2 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0232067332511811 0.0445656969182601 1.12155129393313 0.692307692307692 2.1 2 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.55981199653833e-08 7.98421752184908e-08 1.12001281479193 0.691358024691358 2.1 2 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.20526644716963e-25 1.57279108769737e-23 1.11971869377964 0.691176470588235 2.1 2 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 9.27392449111734e-30 5.73773676124347e-28 1.1181109525407 0.690184049079755 2.1 2 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.52294665939465e-17 8.49686965477727e-16 1.11542259833787 0.688524590163934 2.1 2 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 1.15300503056327e-06 4.79744490786998e-06 1.11542259833787 0.688524590163934 2.1 2 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.012962754962226 0.026276353719726 1.11376274328082 0.6875 2.1 2 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.31861088215972e-12 1.22639430412633e-11 1.1129898336741 0.687022900763359 2.1 2 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.31861088215972e-12 1.22639430412633e-11 1.1129898336741 0.687022900763359 2.1 2 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 6.97480567366197e-17 1.65419141227016e-15 1.10936051899907 0.684782608695652 2.1 2 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00733317731754214 0.0158107747316098 1.10843373493976 0.684210526315789 2.1 2 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.08936597526671e-08 1.54794640239596e-07 1.10635412192861 0.682926829268293 2.1 2 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0024074567062564 0.0059787275619596 1.10161260426321 0.68 2.1 2 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00139195253290378 0.00359482478098381 1.09929829206938 0.678571428571429 2.1 2 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.88617039839718e-11 2.95946299275458e-10 1.09786380104014 0.677685950413223 2.1 2 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.88617039839718e-11 2.95946299275458e-10 1.09786380104014 0.677685950413223 2.1 2 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.30122599563129e-13 1.4353834044832e-12 1.09777571825765 0.677631578947368 2.1 2 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 7.95922922178225e-07 3.3808905022675e-06 1.09589489178433 0.676470588235294 2.1 2 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000471244600280802 0.00129455804285633 1.09589489178433 0.676470588235294 2.1 2 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.28408223081469e-23 1.3744850042498e-21 1.09365872264398 0.675090252707581 2.1 2 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 3.55835000169024e-08 1.77667791312464e-07 1.09257064034313 0.674418604651163 2.1 2 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.58873338224857e-05 0.00018074471824863 1.0917516218721 0.673913043478261 2.1 2 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.92602264117871e-12 1.73463937873247e-11 1.09150185028165 0.673758865248227 2.1 2 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.42521392146772e-12 3.04629963140535e-11 1.08772673110022 0.671428571428571 2.1 2 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 6.34212024818118e-08 3.071776418783e-07 1.08636537098621 0.670588235294118 2.1 2 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 6.34212024818118e-08 3.071776418783e-07 1.08636537098621 0.670588235294118 2.1 2 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.02703683129471e-09 6.06420502461568e-09 1.0849665422452 0.669724770642202 2.1 2 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.07064135495576e-12 5.13785605949616e-11 1.0838972936572 0.669064748201439 2.1 2 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 1.88632272932025e-07 8.52138807562766e-07 1.08001235712079 0.666666666666667 2.1 2 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.000848573429496591 0.00226127338983829 1.08001235712079 0.666666666666667 2.1 2 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00252000904193547 0.00621485765454795 1.08001235712079 0.666666666666667 2.1 2 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00437401033258233 0.00981737650357201 1.08001235712079 0.666666666666667 2.1 2 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00437401033258233 0.00981737650357201 1.08001235712079 0.666666666666667 2.1 2 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0134576519949447 0.0271249841201222 1.08001235712079 0.666666666666667 2.1 2 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0134576519949447 0.0271249841201222 1.08001235712079 0.666666666666667 2.1 2 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0134576519949447 0.0271249841201222 1.08001235712079 0.666666666666667 2.1 2 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0239660196142827 0.0457767059209723 1.08001235712079 0.666666666666667 2.1 2 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0239660196142827 0.0457767059209723 1.08001235712079 0.666666666666667 2.1 2 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0433486438987162 0.0777870369077845 1.08001235712079 0.666666666666667 2.1 2 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0433486438987162 0.0777870369077845 1.08001235712079 0.666666666666667 2.1 2 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0433486438987162 0.0777870369077845 1.08001235712079 0.666666666666667 2.1 2 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0802814181569781 0.131160112557267 1.08001235712079 0.666666666666667 2.1 2 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0802814181569781 0.131160112557267 1.08001235712079 0.666666666666667 2.1 2 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0802814181569781 0.131160112557267 1.08001235712079 0.666666666666667 2.1 2 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0802814181569781 0.131160112557267 1.08001235712079 0.666666666666667 2.1 2 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0802814181569781 0.131160112557267 1.08001235712079 0.666666666666667 2.1 2 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0802814181569781 0.131160112557267 1.08001235712079 0.666666666666667 2.1 2 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0802814181569781 0.131160112557267 1.08001235712079 0.666666666666667 2.1 2 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.13052105318578e-11 9.21748772143556e-11 1.07615517013107 0.664285714285714 2.1 2 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000301266451238391 0.000871345853886647 1.06684147471688 0.658536585365854 2.1 2 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.05110177667579e-71 3.73929457052414e-69 1.06541759553808 0.657657657657658 2.1 2 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 2.76431125046463e-06 1.10494800826156e-05 1.06458360916192 0.657142857142857 2.1 2 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 3.76074037452522e-05 0.000123591998913381 1.0603757688095 0.654545454545455 2.1 2 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 3.76074037452522e-05 0.000123591998913381 1.0603757688095 0.654545454545455 2.1 2 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 6.04976593625349e-07 2.60085103543466e-06 1.06001212828522 0.654320987654321 2.1 2 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 8.10926259198047e-10 4.89236984790551e-09 1.0582379144369 0.653225806451613 2.1 2 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00781049931077501 0.0167822317260395 1.05653382761817 0.652173913043478 2.1 2 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00781049931077501 0.0167822317260395 1.05653382761817 0.652173913043478 2.1 2 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 8.09140467773652e-06 3.04604996201563e-05 1.05546662173168 0.651515151515151 2.1 2 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 3.42487311444904e-14 3.86793209671507e-13 1.05469956750077 0.651041666666667 2.1 2 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0136756800420063 0.0274661581905173 1.05301204819277 0.65 2.1 2 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0136756800420063 0.0274661581905173 1.05301204819277 0.65 2.1 2 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0241585583571621 0.0460826119869192 1.04824728779371 0.647058823529412 2.1 2 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.48198753614787e-09 8.6429027210591e-09 1.04599621988864 0.645669291338583 2.1 2 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.80230422915505e-06 7.39100552763008e-06 1.04583475088279 0.645569620253165 2.1 2 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.11381792478028e-09 2.27780657858457e-08 1.04430946928209 0.644628099173554 2.1 2 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.000316649307864752 0.000913979645216108 1.04401194521676 0.644444444444444 2.1 2 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0431900555308446 0.0777870369077845 1.04144048722362 0.642857142857143 2.1 2 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0431900555308446 0.0777870369077845 1.04144048722362 0.642857142857143 2.1 2 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0431900555308446 0.0777870369077845 1.04144048722362 0.642857142857143 2.1 2 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0431900555308446 0.0777870369077845 1.04144048722362 0.642857142857143 2.1 2 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00787010566827288 0.0168155561050335 1.03681186283596 0.64 2.1 2 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00155813583668025 0.00398065941758706 1.03501184224076 0.638888888888889 2.1 2 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.87278292833067e-06 7.65796007762801e-06 1.03446966736269 0.63855421686747 2.1 2 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 6.76434608591141e-05 0.000214380055239464 1.03346010034834 0.637931034482759 2.1 2 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 6.76434608591141e-05 0.000214380055239464 1.03346010034834 0.637931034482759 2.1 2 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 6.76434608591141e-05 0.000214380055239464 1.03346010034834 0.637931034482759 2.1 2 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0136848251279528 0.0274661581905173 1.03092088634257 0.636363636363636 2.1 2 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0785366754201962 0.13071074751221 1.03092088634257 0.636363636363636 2.1 2 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0785366754201962 0.13071074751221 1.03092088634257 0.636363636363636 2.1 2 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.2231640563889e-08 6.35241770891022e-08 1.02732882750514 0.634146341463415 2.1 2 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 8.82265225450033e-06 3.31256837946015e-05 1.02316960148285 0.631578947368421 2.1 2 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0239567514419204 0.0457767059209723 1.02316960148285 0.631578947368421 2.1 2 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.02870623486545e-38 2.87323264814236e-36 1.02290439422482 0.631415241057543 2.1 2 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00784271545876056 0.0167822317260395 1.02001167061408 0.62962962962963 2.1 2 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00784271545876056 0.0167822317260395 1.02001167061408 0.62962962962963 2.1 2 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00784271545876056 0.0167822317260395 1.02001167061408 0.62962962962963 2.1 2 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.54013914099304e-12 1.41394709524715e-11 1.01970709860136 0.629441624365482 2.1 2 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.68163118371346e-09 9.76718846703778e-09 1.01959208539375 0.629370629370629 2.1 2 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 2.45944471760125e-05 8.57791625771221e-05 1.01829736528532 0.628571428571429 2.1 2 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 8.29670016805854e-29 4.37266827375826e-27 1.01745066570221 0.628048780487805 2.1 2 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000114863338871273 0.000350001137502829 1.01594382746108 0.627118644067797 2.1 2 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 2.56805314810365e-07 1.14556101246128e-06 1.01440412981906 0.626168224299065 2.1 2 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00453372831397866 0.0101120617410527 1.01251158480074 0.625 2.1 2 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00453372831397866 0.0101120617410527 1.01251158480074 0.625 2.1 2 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00453372831397866 0.0101120617410527 1.01251158480074 0.625 2.1 2 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0423047940343772 0.0766298690162615 1.01251158480074 0.625 2.1 2 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0423047940343772 0.0766298690162615 1.01251158480074 0.625 2.1 2 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.146583919176364 0.224772539857722 1.01251158480074 0.625 2.1 2 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.146583919176364 0.224772539857722 1.01251158480074 0.625 2.1 2 1 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.146583919176364 0.224772539857722 1.01251158480074 0.625 2.1 2 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.146583919176364 0.224772539857722 1.01251158480074 0.625 2.1 2 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.146583919176364 0.224772539857722 1.01251158480074 0.625 2.1 2 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.24894775815217e-42 1.48104388320878e-40 1.00602943637052 0.620998719590269 2.1 2 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0234824830467616 0.0450344654656897 1.00286861732645 0.619047619047619 2.1 2 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00447443266981473 0.0100269569907817 1.00059968380309 0.617647058823529 2.1 2 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0132760638752572 0.0268731705469288 0.996934483496115 0.615384615384615 2.1 2 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0755757009347722 0.126225613180963 0.996934483496115 0.615384615384615 2.1 2 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0755757009347722 0.126225613180963 0.996934483496115 0.615384615384615 2.1 2 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0755757009347722 0.126225613180963 0.996934483496115 0.615384615384615 2.1 2 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.000526761326071653 0.00144428009055869 0.990011327360725 0.611111111111111 2.1 2 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 3.07993292826538e-06 1.22082021084168e-05 0.988211306765524 0.61 2.1 2 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.07993292826538e-06 1.22082021084168e-05 0.988211306765524 0.61 2.1 2 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0129306681778202 0.0262487030200259 0.983582682377863 0.607142857142857 2.1 2 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.38861127074374e-05 5.01521278748311e-05 0.982932594682967 0.606741573033708 2.1 2 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00146023664663602 0.00375753480680481 0.978761198640717 0.604166666666667 2.1 2 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 9.26009966517707e-12 7.61683342401559e-11 0.973401695259082 0.600858369098712 2.1 2 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00416839306334598 0.00958259019247388 0.972011121408712 0.6 2.1 2 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0393783585417917 0.0721176373294332 0.972011121408712 0.6 2.1 2 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.137213302546225 0.218957908534206 0.972011121408712 0.6 2.1 2 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.137213302546225 0.218957908534206 0.972011121408712 0.6 2.1 2 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.137213302546225 0.218957908534206 0.972011121408712 0.6 2.1 2 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.137213302546225 0.218957908534206 0.972011121408712 0.6 2.1 2 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.137213302546225 0.218957908534206 0.972011121408712 0.6 2.1 2 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.137213302546225 0.218957908534206 0.972011121408712 0.6 2.1 2 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.137213302546225 0.218957908534206 0.972011121408712 0.6 2.1 2 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00142304814354859 0.00366847374686529 0.972011121408712 0.6 2.1 2 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.012526183277857 0.0254639411491294 0.972011121408712 0.6 2.1 2 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0220397938503313 0.0424392782801373 0.972011121408712 0.6 2.1 2 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0720261094056876 0.123518844804248 0.972011121408712 0.6 2.1 2 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0720261094056876 0.123518844804248 0.972011121408712 0.6 2.1 2 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 4.27994522162518e-08 2.12207736946782e-07 0.961886005560704 0.59375 2.1 2 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 9.50650158064823e-05 0.000293443638812634 0.96001098410737 0.592592592592593 2.1 2 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00228177649957926 0.00568645877215638 0.95878648030111 0.591836734693878 2.1 2 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00228177649957926 0.00568645877215638 0.95878648030111 0.591836734693878 2.1 2 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 5.50486712562614e-05 0.000178437948058451 0.957283680175246 0.590909090909091 2.1 2 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0376346555961522 0.069731920460058 0.957283680175246 0.590909090909091 2.1 2 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 6.34646709151231e-08 3.071776418783e-07 0.954121346168061 0.588957055214724 2.1 2 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0116109568192071 0.0238074806249736 0.952952079812463 0.588235294117647 2.1 2 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0682279878589705 0.11811244126924 0.952952079812463 0.588235294117647 2.1 2 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0682279878589705 0.11811244126924 0.952952079812463 0.588235294117647 2.1 2 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 8.93379797156206e-05 0.000276365098120278 0.952952079812463 0.588235294117647 2.1 2 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 8.93379797156206e-05 0.000276365098120278 0.952952079812463 0.588235294117647 2.1 2 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 8.93379797156206e-05 0.000276365098120278 0.952952079812463 0.588235294117647 2.1 2 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 8.93379797156206e-05 0.000276365098120278 0.952952079812463 0.588235294117647 2.1 2 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 8.93379797156206e-05 0.000276365098120278 0.952952079812463 0.588235294117647 2.1 2 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.69049324105896e-07 7.66105694913024e-07 0.95110765643218 0.587096774193548 2.1 2 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 5.16635532713521e-05 0.000167847571472909 0.950880444856349 0.58695652173913 2.1 2 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00375965922040414 0.00888703500105496 0.950880444856349 0.58695652173913 2.1 2 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.35875599934947e-23 6.04221808460717e-22 0.950448703070398 0.586690017513135 2.1 2 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0202735454227814 0.0399021509496789 0.949666038157937 0.586206896551724 2.1 2 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 1.53482577716092e-07 7.06814589288022e-07 0.9458493313915 0.583850931677019 2.1 2 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 6.41999322721127e-61 1.14195629529021e-58 0.945446582476302 0.583602324080052 2.1 2 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00361429888025099 0.00855764942861425 0.945010812480692 0.583333333333333 2.1 2 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.127799919550268 0.205723173665194 0.945010812480692 0.583333333333333 2.1 2 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.127799919550268 0.205723173665194 0.945010812480692 0.583333333333333 2.1 2 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.127799919550268 0.205723173665194 0.945010812480692 0.583333333333333 2.1 2 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.127799919550268 0.205723173665194 0.945010812480692 0.583333333333333 2.1 2 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.000407863628480878 0.00114928701649166 0.945010812480692 0.583333333333333 2.1 2 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 2.28933657559605e-07 1.02767380033854e-06 0.940010755271799 0.580246913580247 2.1 2 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00346763946743117 0.00823781462797087 0.939610750695088 0.58 2.1 2 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.44963035369847e-10 9.09210982628567e-10 0.93858216749783 0.579365079365079 2.1 2 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.44963035369847e-10 9.09210982628567e-10 0.93858216749783 0.579365079365079 2.1 2 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.44963035369847e-10 9.09210982628567e-10 0.93858216749783 0.579365079365079 2.1 2 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0643733541103238 0.111711320608525 0.93790546802595 0.578947368421053 2.1 2 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.06780473431354e-17 5.16225638057574e-16 0.937140767277458 0.57847533632287 2.1 2 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.56917887094106e-08 1.30104680902104e-07 0.936573215940686 0.578125 2.1 2 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.00111180527776905 0.00294618046604349 0.936573215940686 0.578125 2.1 2 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00591695629855707 0.0131354583663755 0.936010709504685 0.577777777777778 2.1 2 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0339903347254321 0.0631439246922845 0.934626078277607 0.576923076923077 2.1 2 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00965995095204008 0.0199508130693077 0.925724877532106 0.571428571428571 2.1 2 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0605728592018317 0.105373079027147 0.925724877532106 0.571428571428571 2.1 2 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.118756561473342 0.19247219473413 0.925724877532106 0.571428571428571 2.1 2 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.118756561473342 0.19247219473413 0.925724877532106 0.571428571428571 2.1 2 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.118756561473342 0.19247219473413 0.925724877532106 0.571428571428571 2.1 2 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 1.95701117232926e-06 7.95664828064153e-06 0.919752458967383 0.567741935483871 2.1 2 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.0304047113046053 0.0577648921047442 0.918010503552672 0.566666666666667 2.1 2 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0568902429967408 0.0990879018168448 0.91566265060241 0.565217391304348 2.1 2 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0568902429967408 0.0990879018168448 0.91566265060241 0.565217391304348 2.1 2 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 5.201267315427e-13 5.13986346517543e-12 0.913967676547407 0.564171122994652 2.1 2 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0157165532059683 0.0311919877435046 0.913856609871438 0.564102564102564 2.1 2 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0157165532059683 0.0311919877435046 0.913856609871438 0.564102564102564 2.1 2 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 3.82763802876028e-06 1.50047628510355e-05 0.906802828148588 0.559748427672956 2.1 2 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 3.82763802876028e-06 1.50047628510355e-05 0.906802828148588 0.559748427672956 2.1 2 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.102295137239018 0.166551464863985 0.900010297600659 0.555555555555556 2.1 2 1 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.229462045450596 0.330739777100594 0.900010297600659 0.555555555555556 2.1 2 1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.229462045450596 0.330739777100594 0.900010297600659 0.555555555555556 2.1 2 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.229462045450596 0.330739777100594 0.900010297600659 0.555555555555556 2.1 2 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.229462045450596 0.330739777100594 0.900010297600659 0.555555555555556 2.1 2 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.229462045450596 0.330739777100594 0.900010297600659 0.555555555555556 2.1 2 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.229462045450596 0.330739777100594 0.900010297600659 0.555555555555556 2.1 2 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0949227931385298 0.154725240133022 0.891010194624653 0.55 2.1 2 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000124780316677453 0.000379406817589777 0.889682310579012 0.549180327868853 2.1 2 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.043831843185133 0.0784562425816908 0.888397261502586 0.548387096774194 2.1 2 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.043831843185133 0.0784562425816908 0.888397261502586 0.548387096774194 2.1 2 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0410143276589261 0.0748248567418613 0.88364647400792 0.545454545454545 2.1 2 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0410143276589261 0.0748248567418613 0.88364647400792 0.545454545454545 2.1 2 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0410143276589261 0.0748248567418613 0.88364647400792 0.545454545454545 2.1 2 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.207625255097459 0.302715920085741 0.88364647400792 0.545454545454545 2.1 2 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.207625255097459 0.302715920085741 0.88364647400792 0.545454545454545 2.1 2 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.207625255097459 0.302715920085741 0.88364647400792 0.545454545454545 2.1 2 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.207625255097459 0.302715920085741 0.88364647400792 0.545454545454545 2.1 2 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00123141348316447 0.00319763026741432 0.882010091648646 0.544444444444444 2.1 2 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.038369350820334 0.0710007623112292 0.879438633655501 0.542857142857143 2.1 2 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.40099435056124e-05 0.000112811537548919 0.877080098935674 0.54140127388535 2.1 2 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0759605960883051 0.126719728292683 0.8723176730591 0.538461538461538 2.1 2 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.18872817460168 0.277438215349371 0.8723176730591 0.538461538461538 2.1 2 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.18872817460168 0.277438215349371 0.8723176730591 0.538461538461538 2.1 2 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.18872817460168 0.277438215349371 0.8723176730591 0.538461538461538 2.1 2 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.18872817460168 0.277438215349371 0.8723176730591 0.538461538461538 2.1 2 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.18872817460168 0.277438215349371 0.8723176730591 0.538461538461538 2.1 2 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.18872817460168 0.277438215349371 0.8723176730591 0.538461538461538 2.1 2 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0335675903403548 0.062440105953366 0.8723176730591 0.538461538461538 2.1 2 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0335675903403548 0.062440105953366 0.8723176730591 0.538461538461538 2.1 2 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.000149377406332477 0.000452263934491733 0.86786707268635 0.535714285714286 2.1 2 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0705743325414033 0.12202585079759 0.86786707268635 0.535714285714286 2.1 2 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.000140987448028074 0.000427772150413539 0.86705217402655 0.535211267605634 2.1 2 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 3.10018824188528e-05 0.000104787835349234 0.8665215423411 0.534883720930233 2.1 2 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.172162792407805 0.254929920495637 0.864009885696633 0.533333333333333 2.1 2 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.172162792407805 0.254929920495637 0.864009885696633 0.533333333333333 2.1 2 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00022568828730724 0.000660811590202062 0.863221555508953 0.532846715328467 2.1 2 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0609941789533213 0.105976455006809 0.86063484708063 0.53125 2.1 2 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.000319981398477718 0.000921727793590674 0.857656871831216 0.529411764705882 2.1 2 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.021024960390945 0.0410748185484579 0.855858849039117 0.528301886792453 2.1 2 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.021024960390945 0.0410748185484579 0.855858849039117 0.528301886792453 2.1 2 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0527977766888413 0.0941494188323573 0.855009782720626 0.527777777777778 2.1 2 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.049150072334341 0.0877547715580518 0.852641334569045 0.526315789473684 2.1 2 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.144430451826456 0.224581372110906 0.852641334569045 0.526315789473684 2.1 2 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.000424429152389629 0.00119360214199692 0.851396602693762 0.525547445255474 2.1 2 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 9.53223131107379e-06 3.56020082825669e-05 0.849964881949322 0.524663677130045 2.1 2 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.122144296836182 0.197737581795093 0.845227062094532 0.521739130434783 2.1 2 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.103913467891402 0.168992988353674 0.840009611093948 0.518518518518518 2.1 2 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0822227709536164 0.134177755810775 0.834555003229702 0.515151515151515 2.1 2 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0454836527891358 0.0813106004006787 0.826540069225095 0.510204081632653 2.1 2 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00434988546353685 0.00979412502312173 0.824736709074058 0.509090909090909 2.1 2 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0367285323536707 0.0681417229977489 0.824736709074058 0.509090909090909 2.1 2 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.193938110514382 0.284216201093683 0.810009267840593 0.5 2.1 2 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.193938110514382 0.284216201093683 0.810009267840593 0.5 2.1 2 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.193938110514382 0.284216201093683 0.810009267840593 0.5 2.1 2 1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.321710788354967 0.440728588444293 0.810009267840593 0.5 2.1 2 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.321710788354967 0.440728588444293 0.810009267840593 0.5 2.1 2 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.321710788354967 0.440728588444293 0.810009267840593 0.5 2.1 2 1 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.321710788354967 0.440728588444293 0.810009267840593 0.5 2.1 2 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.321710788354967 0.440728588444293 0.810009267840593 0.5 2.1 2 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.321710788354967 0.440728588444293 0.810009267840593 0.5 2.1 2 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.321710788354967 0.440728588444293 0.810009267840593 0.5 2.1 2 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.321710788354967 0.440728588444293 0.810009267840593 0.5 2.1 2 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0288652144333069 0.0549868810422969 0.810009267840593 0.5 2.1 2 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0790933218230128 0.131053853708271 0.810009267840593 0.5 2.1 2 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.126438291369268 0.204456464339168 0.810009267840593 0.5 2.1 2 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.149215056728534 0.228315081424413 0.810009267840593 0.5 2.1 2 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.162498600212007 0.241373181734537 0.810009267840593 0.5 2.1 2 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.162498600212007 0.241373181734537 0.810009267840593 0.5 2.1 2 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.162498600212007 0.241373181734537 0.810009267840593 0.5 2.1 2 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.177316737409148 0.262288687456567 0.810009267840593 0.5 2.1 2 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.212708614045701 0.308546745960278 0.810009267840593 0.5 2.1 2 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.212708614045701 0.308546745960278 0.810009267840593 0.5 2.1 2 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.23408635564681 0.336809791795157 0.810009267840593 0.5 2.1 2 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.287450590644649 0.401415299791301 0.810009267840593 0.5 2.1 2 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.287450590644649 0.401415299791301 0.810009267840593 0.5 2.1 2 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.1372526032414 0.218957908534206 0.810009267840593 0.5 2.1 2 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.258699787730018 0.36557080232355 0.810009267840593 0.5 2.1 2 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.258699787730018 0.36557080232355 0.810009267840593 0.5 2.1 2 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.258699787730018 0.36557080232355 0.810009267840593 0.5 2.1 2 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.149012824422275 0.228251075514422 0.785463532451484 0.484848484848485 2.1 2 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.208570083723012 0.303161623225583 0.777608897126969 0.48 2.1 2 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.208570083723012 0.303161623225583 0.777608897126969 0.48 2.1 2 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.208570083723012 0.303161623225583 0.777608897126969 0.48 2.1 2 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.0300502816481305 0.0571678486434353 0.771437397943422 0.476190476190476 2.1 2 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00150431588986632 0.00386397384707541 0.768714677715386 0.474509803921569 2.1 2 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.274158960043022 0.387031944584544 0.767377201112141 0.473684210526316 2.1 2 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 4.32207581478689e-05 0.000141712301484833 0.759281414703102 0.468686868686869 2.1 2 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0537247143093978 0.095682438626124 0.758306548616725 0.468085106382979 2.1 2 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.238105270401748 0.342246262405744 0.752151462994836 0.464285714285714 2.1 2 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.372069804395766 0.497141156483732 0.747700862622086 0.461538461538462 2.1 2 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.372069804395766 0.497141156483732 0.747700862622086 0.461538461538462 2.1 2 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.372069804395766 0.497141156483732 0.747700862622086 0.461538461538462 2.1 2 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.372069804395766 0.497141156483732 0.747700862622086 0.461538461538462 2.1 2 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.372069804395766 0.497141156483732 0.747700862622086 0.461538461538462 2.1 2 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.171922618268657 0.254929920495637 0.742508495520544 0.458333333333333 2.1 2 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.309839904844554 0.431411139524267 0.736372061673266 0.454545454545455 2.1 2 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.416782066069557 0.536484611912488 0.736372061673266 0.454545454545455 2.1 2 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.416782066069557 0.536484611912488 0.736372061673266 0.454545454545455 2.1 2 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.416782066069557 0.536484611912488 0.736372061673266 0.454545454545455 2.1 2 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.416782066069557 0.536484611912488 0.736372061673266 0.454545454545455 2.1 2 1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.416782066069557 0.536484611912488 0.736372061673266 0.454545454545455 2.1 2 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.416782066069557 0.536484611912488 0.736372061673266 0.454545454545455 2.1 2 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.416782066069557 0.536484611912488 0.736372061673266 0.454545454545455 2.1 2 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.416782066069557 0.536484611912488 0.736372061673266 0.454545454545455 2.1 2 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.339794200566454 0.458754409303667 0.729008341056534 0.45 2.1 2 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.339794200566454 0.458754409303667 0.729008341056534 0.45 2.1 2 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.150896082156774 0.230639231910945 0.727834414581403 0.449275362318841 2.1 2 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.288778000651122 0.402873622477006 0.726215205650187 0.448275862068966 2.1 2 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0221534470999672 0.0426004800314234 0.722176937592818 0.44578313253012 2.1 2 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.313977823831061 0.436745301379863 0.720008238080527 0.444444444444444 2.1 2 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.373723716934817 0.498882597746946 0.720008238080527 0.444444444444444 2.1 2 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.292196530523442 0.407243548418079 0.714714059859347 0.441176470588235 2.1 2 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.25647811615731 0.363876729104539 0.708758109360519 0.4375 2.1 2 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.25647811615731 0.363876729104539 0.708758109360519 0.4375 2.1 2 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.412456672073732 0.536484611912488 0.708758109360519 0.4375 2.1 2 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.203736563778286 0.298268652527264 0.703429101019463 0.434210526315789 2.1 2 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.258271286526983 0.36557080232355 0.703026911710704 0.433962264150943 2.1 2 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.31694086482196 0.440436377579735 0.700548555970243 0.432432432432432 2.1 2 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.457097316895076 0.585990524271796 0.69429365814908 0.428571428571429 2.1 2 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.245766696367836 0.352546379971201 0.686125497464973 0.423529411764706 2.1 2 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.245766696367836 0.352546379971201 0.686125497464973 0.423529411764706 2.1 2 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.397322200868979 0.5196594594086 0.679362611737272 0.419354838709677 2.1 2 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.397322200868979 0.5196594594086 0.679362611737272 0.419354838709677 2.1 2 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.229635207150658 0.330739777100594 0.676070727488999 0.417322834645669 2.1 2 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.436915196093511 0.560622474338202 0.675007723200494 0.416666666666667 2.1 2 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.489663328236475 0.617994921870253 0.667066455868724 0.411764705882353 2.1 2 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.46307645239217 0.593121324711124 0.660007551573817 0.407407407407407 2.1 2 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.409695965626601 0.535351110272409 0.653233280516607 0.403225806451613 2.1 2 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.393605590324741 0.515746551594942 0.648007414272475 0.4 2.1 2 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.486575716691742 0.617994921870253 0.648007414272474 0.4 2.1 2 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.411978546533752 0.536484611912488 0.644523503443053 0.397849462365591 2.1 2 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.474067891356276 0.60393787770813 0.64125733704047 0.395833333333333 2.1 2 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.507891761521087 0.635646417453392 0.638189120116831 0.393939393939394 2.1 2 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.464307016788977 0.594162666268628 0.635703476026795 0.392405063291139 2.1 2 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.502094530802285 0.628944117369412 0.633920296570899 0.391304347826087 2.1 2 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.563443080882984 0.703315354470602 0.630007208320461 0.388888888888889 2.1 2 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.584467747355367 0.725106891444366 0.617149918354738 0.380952380952381 2.1 2 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.609096049289663 0.75318187714992 0.614026537670381 0.379024390243902 2.1 2 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.564595402237841 0.704136071327299 0.612979986473962 0.378378378378378 2.1 2 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.578165194673235 0.717913675410134 0.612979986473962 0.378378378378378 2.1 2 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.591166125378632 0.732778219872643 0.607506950880445 0.375 2.1 2 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.592413196573918 0.733684924912694 0.607506950880445 0.375 2.1 2 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.614737872596548 0.75318187714992 0.607506950880445 0.375 2.1 2 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.631873116019866 0.76328985067595 0.596848934198332 0.368421052631579 2.1 2 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.634262701730823 0.765526568755693 0.594006796416435 0.366666666666667 2.1 2 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.67776442509298 0.809789065413359 0.584268980081739 0.360655737704918 2.1 2 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.660641374956964 0.791990460458096 0.583206672845227 0.36 2.1 2 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.671370122866539 0.803498473371812 0.578578048457566 0.357142857142857 2.1 2 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.671370122866539 0.803498473371812 0.578578048457566 0.357142857142857 2.1 2 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.673058315030154 0.804842001922612 0.578578048457566 0.357142857142857 2.1 2 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.682960351338406 0.814629153356707 0.571771247887478 0.352941176470588 2.1 2 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.682960351338406 0.814629153356707 0.571771247887478 0.352941176470588 2.1 2 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.693712821703353 0.826761595715135 0.567006487488415 0.35 2.1 2 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.713136660676822 0.849199554931479 0.560775646966564 0.346153846153846 2.1 2 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.766886125412203 0.886497933762441 0.557711299168933 0.344262295081967 2.1 2 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.75290421164393 0.885440242288688 0.553177060964307 0.341463414634146 2.1 2 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.766255855274589 0.886489497606292 0.551495671721255 0.340425531914894 2.1 2 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.737613973099562 0.868894605729037 0.540006178560395 0.333333333333333 2.1 2 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.737613973099562 0.868894605729037 0.540006178560395 0.333333333333333 2.1 2 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.748335358877346 0.880795050192277 0.540006178560395 0.333333333333333 2.1 2 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.765835733111656 0.886489497606292 0.540006178560395 0.333333333333333 2.1 2 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.765835733111656 0.886489497606292 0.540006178560395 0.333333333333333 2.1 2 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.929739215081358 1 0.533420737358439 0.329268292682927 2.1 2 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.844194755127924 0.963389499381453 0.531568582020389 0.328125 2.1 2 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.80457337238503 0.924804449841598 0.522586624413286 0.32258064516129 2.1 2 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.80457337238503 0.924804449841598 0.522586624413286 0.32258064516129 2.1 2 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.868779901807062 0.981169682755118 0.498467241748057 0.307692307692308 2.1 2 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.964567115057634 1 0.484335438502623 0.298969072164948 2.1 2 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.892028941884709 1 0.476476039906231 0.294117647058824 2.1 2 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.964029613581616 1 0.471650966084396 0.291139240506329 2.1 2 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.999147420883705 1 0.470123026040815 0.290196078431373 2.1 2 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.897154016199835 1 0.453605189990732 0.28 2.1 2 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.931989449979446 1 0.44182323700396 0.272727272727273 2.1 2 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.900912222725307 1 0.44182323700396 0.272727272727273 2.1 2 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.900912222725307 1 0.44182323700396 0.272727272727273 2.1 2 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.900912222725307 1 0.44182323700396 0.272727272727273 2.1 2 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.977148754125002 1 0.437147858834606 0.26984126984127 2.1 2 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.984134508873382 1 0.433526087013275 0.267605633802817 2.1 2 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.968741437259278 1 0.429800835997049 0.26530612244898 2.1 2 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.978483697293847 1 0.426320667284523 0.263157894736842 2.1 2 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.9063317276439 1 0.426320667284523 0.263157894736842 2.1 2 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.955907210367358 1 0.426320667284523 0.263157894736842 2.1 2 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.923888310412166 1 0.422613531047266 0.260869565217391 2.1 2 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999868928943649 1 0.418069299530629 0.258064516129032 2.1 2 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.971300135467695 1 0.414423346337048 0.255813953488372 2.1 2 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999999957546 1 0.371602189885633 0.229381443298969 2.1 2 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.991883914319091 1 0.371254247760272 0.229166666666667 2.1 2 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999999701792858 1 0.3658106370893 0.225806451612903 2.1 2 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.979221809270454 1 0.3658106370893 0.225806451612903 2.1 2 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999993602189 1 0.364504170528267 0.225 2.1 2 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.999769705260503 1 0.360004119040264 0.222222222222222 2.1 2 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.991454940086552 1 0.355613824905626 0.219512195121951 2.1 2 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.971429168628381 1 0.352177942539388 0.217391304347826 2.1 2 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.986697760163154 1 0.335176248761625 0.206896551724138 2.1 2 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.993701655501915 1 0.324003707136237 0.2 2.1 2 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.984901078970216 1 0.324003707136237 0.2 2.1 2 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.992925757048569 1 0.313551974647972 0.193548387096774 2.1 2 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.306048841753373 0.188916876574307 2.1 2 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999999198828 1 0.285344173898391 0.176136363636364 2.1 2 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.998112227518314 1 0.277717463259632 0.171428571428571 2.1 2 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999915674429 1 0.25500291765352 0.157407407407407 2.1 2 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.253402537678884 0.156419529837251 2.1 2 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.998630822244299 1 0.253127896200185 0.15625 2.1 2 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999991092877 1 0.198002265472145 0.122222222222222 2.1 2 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0235163980985979 0.0145161290322581 2.1 2 1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.000332522228958782 0.00146042941916157 2.79845482028888 1 20.1 20 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00126359192068709 0.00478215772111097 2.79845482028888 1 20.1 20 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00126359192068709 0.00478215772111097 2.79845482028888 1 20.1 20 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00126359192068709 0.00478215772111097 2.79845482028888 1 20.1 20 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 1.08522550262235e-06 8.82443365846629e-06 2.58318906488204 0.923076923076923 20.1 20 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 4.62281774852074e-05 0.000255963799850001 2.51860933825999 0.9 20.1 20 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000538831713597965 0.00225516920132325 2.44864796775277 0.875 20.1 20 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 5.75580359305317e-06 4.07487985717148e-05 2.39867556024761 0.857142857142857 20.1 20 1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.00180266694298086 0.00636524828749819 2.39867556024761 0.857142857142857 20.1 20 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00180266694298086 0.00636524828749819 2.39867556024761 0.857142857142857 20.1 20 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.00180266694298086 0.00636524828749819 2.39867556024761 0.857142857142857 20.1 20 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 6.71882806003193e-08 7.96741027452119e-07 2.37868659724555 0.85 20.1 20 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 6.09300050789861e-05 0.000329670711891244 2.33204568357407 0.833333333333333 20.1 20 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 6.09300050789861e-05 0.000329670711891244 2.33204568357407 0.833333333333333 20.1 20 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00591894037932861 0.0174382032293677 2.33204568357407 0.833333333333333 20.1 20 1 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.00591894037932861 0.0174382032293677 2.33204568357407 0.833333333333333 20.1 20 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00591894037932861 0.0174382032293677 2.33204568357407 0.833333333333333 20.1 20 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 8.49301378433345e-08 9.66844689208519e-07 2.28964485296363 0.818181818181818 20.1 20 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 8.49301378433345e-08 9.66844689208519e-07 2.28964485296363 0.818181818181818 20.1 20 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 8.21094882130187e-07 6.83285390217109e-06 2.23876385623111 0.8 20.1 20 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 3.1759448012793e-08 4.22370002914347e-07 2.2387638562311 0.8 20.1 20 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 7.58569915505114e-06 5.21471009547718e-05 2.1765759713358 0.777777777777778 20.1 20 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00186914536169826 0.00651910257278585 2.1765759713358 0.777777777777778 20.1 20 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00186914536169826 0.00651910257278585 2.1765759713358 0.777777777777778 20.1 20 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00186914536169826 0.00651910257278585 2.1765759713358 0.777777777777778 20.1 20 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00186914536169826 0.00651910257278585 2.1765759713358 0.777777777777778 20.1 20 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 8.79115268463766e-07 7.2275791844018e-06 2.16244236113232 0.772727272727273 20.1 20 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000201225767484279 0.000932717482508564 2.15265755406837 0.769230769230769 20.1 20 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.25906166175928e-05 0.000136213760367943 2.13999486257385 0.764705882352941 20.1 20 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 2.59923287794235e-06 2.03225735456701e-05 2.13215605355343 0.761904761904762 20.1 20 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.59923287794235e-06 2.03225735456701e-05 2.13215605355343 0.761904761904762 20.1 20 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 6.62121817708429e-05 0.000351566920372797 2.09884111521666 0.75 20.1 20 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 6.62121817708429e-05 0.000351566920372797 2.09884111521666 0.75 20.1 20 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 6.62121817708429e-05 0.000351566920372797 2.09884111521666 0.75 20.1 20 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00559417263112958 0.0166190138916438 2.09884111521666 0.75 20.1 20 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.00559417263112958 0.0166190138916438 2.09884111521666 0.75 20.1 20 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00559417263112958 0.0166190138916438 2.09884111521666 0.75 20.1 20 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00559417263112958 0.0166190138916438 2.09884111521666 0.75 20.1 20 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00559417263112958 0.0166190138916438 2.09884111521666 0.75 20.1 20 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 8.83765831402609e-07 7.2275791844018e-06 2.09884111521666 0.75 20.1 20 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00059418598968875 0.00243667626319046 2.09884111521666 0.75 20.1 20 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00059418598968875 0.00243667626319046 2.09884111521666 0.75 20.1 20 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 2.17935052705296e-05 0.000133099390557784 2.06201934126549 0.736842105263158 20.1 20 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.01049107057319e-07 1.12338186986378e-06 2.05220020154518 0.733333333333333 20.1 20 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000190577655247559 0.000889154109564841 2.05220020154518 0.733333333333333 20.1 20 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 8.48411602946976e-07 7.01912622670667e-06 2.04502467636495 0.730769230769231 20.1 20 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.07574571416543e-11 4.8422723791105e-10 2.04053997312731 0.729166666666667 20.1 20 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00171427455760856 0.0061291776268266 2.035239869301 0.727272727272727 20.1 20 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00171427455760856 0.0061291776268266 2.035239869301 0.727272727272727 20.1 20 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00171427455760856 0.0061291776268266 2.035239869301 0.727272727272727 20.1 20 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.14862476116522e-08 1.60244415209619e-07 2.02110625909753 0.722222222222222 20.1 20 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 9.4857227700884e-08 1.06284909463274e-06 2.01138940208263 0.71875 20.1 20 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.00411791361007e-05 0.00012399390395944 1.99889630020634 0.714285714285714 20.1 20 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000537236828294986 0.00225512686331494 1.99889630020634 0.714285714285714 20.1 20 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000537236828294986 0.00225512686331494 1.99889630020634 0.714285714285714 20.1 20 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.016209623970198 0.0409562112723712 1.99889630020634 0.714285714285714 20.1 20 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.016209623970198 0.0409562112723712 1.99889630020634 0.714285714285714 20.1 20 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.016209623970198 0.0409562112723712 1.99889630020634 0.714285714285714 20.1 20 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.016209623970198 0.0409562112723712 1.99889630020634 0.714285714285714 20.1 20 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.016209623970198 0.0409562112723712 1.99889630020634 0.714285714285714 20.1 20 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.016209623970198 0.0409562112723712 1.99889630020634 0.714285714285714 20.1 20 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 6.55423932118442e-06 4.58847180742726e-05 1.98223883103796 0.708333333333333 20.1 20 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.98756104530952e-11 9.85736023260478e-10 1.97537987314509 0.705882352941177 20.1 20 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.98756104530952e-11 9.85736023260478e-10 1.97537987314509 0.705882352941177 20.1 20 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 8.67971266000454e-08 9.80256437713211e-07 1.97537987314509 0.705882352941177 20.1 20 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 7.09652081180486e-07 5.94020536188136e-06 1.95891837420222 0.7 20.1 20 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.49521766811275e-05 0.000302062514453152 1.95891837420222 0.7 20.1 20 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00480995636388088 0.0145319913074363 1.95891837420222 0.7 20.1 20 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00480995636388088 0.0145319913074363 1.95891837420222 0.7 20.1 20 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00480995636388088 0.0145319913074363 1.95891837420222 0.7 20.1 20 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00480995636388088 0.0145319913074363 1.95891837420222 0.7 20.1 20 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00480995636388088 0.0145319913074363 1.95891837420222 0.7 20.1 20 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.07725163665691e-09 1.76198744708366e-08 1.9467511793314 0.695652173913043 20.1 20 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.78114914265624e-05 0.000111655296475764 1.9467511793314 0.695652173913043 20.1 20 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00147834648964881 0.00547835170513087 1.93739179866153 0.692307692307692 20.1 20 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00147834648964881 0.00547835170513087 1.93739179866153 0.692307692307692 20.1 20 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00147834648964881 0.00547835170513087 1.93739179866153 0.692307692307692 20.1 20 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00147834648964881 0.00547835170513087 1.93739179866153 0.692307692307692 20.1 20 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00147834648964881 0.00547835170513087 1.93739179866153 0.692307692307692 20.1 20 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000464181696896334 0.00199556058816762 1.92393768894861 0.6875 20.1 20 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 4.03976282307641e-12 1.36871011838994e-10 1.91005646464162 0.682539682539683 20.1 20 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 5.03709899917435e-06 3.58805769730062e-05 1.89895148519603 0.678571428571429 20.1 20 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.18883936805235e-09 3.36881732308313e-08 1.88467365448027 0.673469387755102 20.1 20 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 3.07506748025164e-12 1.09395525609952e-10 1.87955920765671 0.671641791044776 20.1 20 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.000389505010375528 0.00168983423708652 1.86563654685925 0.666666666666667 20.1 20 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000389505010375528 0.00168983423708652 1.86563654685925 0.666666666666667 20.1 20 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00123055517438984 0.00469458448567491 1.86563654685925 0.666666666666667 20.1 20 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00123055517438984 0.00469458448567491 1.86563654685925 0.666666666666667 20.1 20 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00395445169344819 0.0126738395490468 1.86563654685925 0.666666666666667 20.1 20 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00395445169344819 0.0126738395490468 1.86563654685925 0.666666666666667 20.1 20 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00395445169344819 0.0126738395490468 1.86563654685925 0.666666666666667 20.1 20 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0130442271699922 0.0339756240688861 1.86563654685925 0.666666666666667 20.1 20 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.36391800955745e-10 9.19621123807259e-09 1.84897907769087 0.660714285714286 20.1 20 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.4413531843199e-08 1.97215921277617e-07 1.84578934955224 0.659574468085106 20.1 20 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.48125834830202e-14 1.30771504801251e-12 1.84368788160209 0.658823529411765 20.1 20 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.48125834830202e-14 1.30771504801251e-12 1.84368788160209 0.658823529411765 20.1 20 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.48125834830202e-14 1.30771504801251e-12 1.84368788160209 0.658823529411765 20.1 20 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.48125834830202e-14 1.30771504801251e-12 1.84368788160209 0.658823529411765 20.1 20 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 3.36185023054126e-05 0.000188343026695284 1.82975892095812 0.653846153846154 20.1 20 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.44822803102489e-11 3.49292964092952e-10 1.82507923062318 0.652173913043478 20.1 20 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000103417616061919 0.000503983793342847 1.82507923062318 0.652173913043478 20.1 20 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000103417616061919 0.000503983793342847 1.82507923062318 0.652173913043478 20.1 20 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00032039789562407 0.0014203308581715 1.81899563318777 0.65 20.1 20 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00032039789562407 0.0014203308581715 1.81899563318777 0.65 20.1 20 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00032039789562407 0.0014203308581715 1.81899563318777 0.65 20.1 20 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.01647111195946e-08 1.43211722011713e-07 1.81076488371634 0.647058823529412 20.1 20 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0010018575879521 0.00389520040343125 1.81076488371634 0.647058823529412 20.1 20 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.72708086538227e-14 1.89415573979963e-12 1.80344866196395 0.644444444444444 20.1 20 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 6.01325387901933e-24 1.22240860997779e-21 1.80150529056097 0.64375 20.1 20 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00317234388008569 0.0104496419938934 1.79900667018571 0.642857142857143 20.1 20 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 8.45757409829032e-05 0.000428616440465751 1.79101108498488 0.64 20.1 20 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 8.45757409829032e-05 0.000428616440465751 1.79101108498488 0.64 20.1 20 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 8.45757409829032e-05 0.000428616440465751 1.79101108498488 0.64 20.1 20 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.3478272931029e-09 3.51679814535308e-08 1.78522117846015 0.637931034482759 20.1 20 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.3478272931029e-09 3.51679814535308e-08 1.78522117846015 0.637931034482759 20.1 20 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0102273995248575 0.0278271310207881 1.78083488563838 0.636363636363636 20.1 20 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0102273995248575 0.0278271310207881 1.78083488563838 0.636363636363636 20.1 20 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0102273995248575 0.0278271310207881 1.78083488563838 0.636363636363636 20.1 20 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0102273995248575 0.0278271310207881 1.78083488563838 0.636363636363636 20.1 20 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0102273995248575 0.0278271310207881 1.78083488563838 0.636363636363636 20.1 20 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0102273995248575 0.0278271310207881 1.78083488563838 0.636363636363636 20.1 20 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 6.84623820418441e-05 0.000358169006049795 1.76199007203374 0.62962962962963 20.1 20 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.84623820418441e-05 0.000358169006049795 1.76199007203374 0.62962962962963 20.1 20 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 6.06360756371261e-06 4.2715413679025e-05 1.75902874418158 0.628571428571429 20.1 20 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.13787478009117e-11 8.41170830295676e-10 1.7536983540477 0.626666666666667 20.1 20 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.13787478009117e-11 8.41170830295676e-10 1.7536983540477 0.626666666666667 20.1 20 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.13787478009117e-11 8.41170830295676e-10 1.7536983540477 0.626666666666667 20.1 20 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.13787478009117e-11 8.41170830295676e-10 1.7536983540477 0.626666666666667 20.1 20 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.13787478009117e-11 8.41170830295676e-10 1.7536983540477 0.626666666666667 20.1 20 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.29707913072915e-09 2.07386921688493e-08 1.74903426268055 0.625 20.1 20 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00250784430354569 0.00841665670741866 1.74903426268055 0.625 20.1 20 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00250784430354569 0.00841665670741866 1.74903426268055 0.625 20.1 20 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00250784430354569 0.00841665670741866 1.74903426268055 0.625 20.1 20 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0339020428686453 0.0741053870999728 1.74903426268055 0.625 20.1 20 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0339020428686453 0.0741053870999728 1.74903426268055 0.625 20.1 20 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0339020428686453 0.0741053870999728 1.74903426268055 0.625 20.1 20 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0339020428686453 0.0741053870999728 1.74903426268055 0.625 20.1 20 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0339020428686453 0.0741053870999728 1.74903426268055 0.625 20.1 20 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000208570316769588 0.000963621950529623 1.74903426268055 0.625 20.1 20 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.03373440764496e-13 1.34906376939962e-11 1.74527289867479 0.623655913978495 20.1 20 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 5.49783494331457e-05 0.000302062514453152 1.73697195742068 0.620689655172414 20.1 20 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.75281935417201e-11 6.02655683228735e-10 1.73575045815386 0.620253164556962 20.1 20 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.75281935417201e-11 6.02655683228735e-10 1.73575045815386 0.620253164556962 20.1 20 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000638286446885015 0.00258769690574751 1.73237679351216 0.619047619047619 20.1 20 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.000638286446885015 0.00258769690574751 1.73237679351216 0.619047619047619 20.1 20 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000638286446885015 0.00258769690574751 1.73237679351216 0.619047619047619 20.1 20 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000638286446885015 0.00258769690574751 1.73237679351216 0.619047619047619 20.1 20 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.23551752389257e-11 5.04943085158592e-10 1.7274412470919 0.617283950617284 20.1 20 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.23551752389257e-11 5.04943085158592e-10 1.7274412470919 0.617283950617284 20.1 20 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.59857861421342e-07 3.55609539446229e-06 1.72670616571016 0.617021276595745 20.1 20 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00791622001952719 0.022306497203539 1.7221260432547 0.615384615384615 20.1 20 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00791622001952719 0.022306497203539 1.7221260432547 0.615384615384615 20.1 20 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00791622001952719 0.022306497203539 1.7221260432547 0.615384615384615 20.1 20 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00791622001952719 0.022306497203539 1.7221260432547 0.615384615384615 20.1 20 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.81066728784873e-11 4.29429925101457e-10 1.71953247993654 0.614457831325301 20.1 20 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.17094701619112e-05 7.82280565276977e-05 1.71016683462098 0.611111111111111 20.1 20 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.17094701619112e-05 7.82280565276977e-05 1.71016683462098 0.611111111111111 20.1 20 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00196412592414385 0.00677022762432239 1.71016683462098 0.611111111111111 20.1 20 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00196412592414385 0.00677022762432239 1.71016683462098 0.611111111111111 20.1 20 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000503191273871796 0.00213600388295306 1.70340728191497 0.608695652173913 20.1 20 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000503191273871796 0.00213600388295306 1.70340728191497 0.608695652173913 20.1 20 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.24058693053071e-10 2.17945086684592e-09 1.70032697941603 0.607594936708861 20.1 20 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.85108129079248e-07 1.90875991072297e-06 1.68963309904234 0.60377358490566 20.1 20 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.4777626555618e-15 2.47442812943222e-13 1.68832398248833 0.603305785123967 20.1 20 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.4777626555618e-15 2.47442812943222e-13 1.68832398248833 0.603305785123967 20.1 20 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 6.37766359881037e-11 1.22640747312259e-09 1.67907289217333 0.6 20.1 20 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.99325443192766e-06 1.59348373968149e-05 1.67907289217333 0.6 20.1 20 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00152879496277859 0.00557995554992021 1.67907289217333 0.6 20.1 20 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00152879496277859 0.00557995554992021 1.67907289217333 0.6 20.1 20 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0253956333791592 0.0577284126174818 1.67907289217333 0.6 20.1 20 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.03089080312664e-08 4.9025278742301e-07 1.67907289217333 0.6 20.1 20 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.03089080312664e-08 4.9025278742301e-07 1.67907289217333 0.6 20.1 20 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.03089080312664e-08 4.9025278742301e-07 1.67907289217333 0.6 20.1 20 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.03089080312664e-08 4.9025278742301e-07 1.67907289217333 0.6 20.1 20 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.03089080312664e-08 4.9025278742301e-07 1.67907289217333 0.6 20.1 20 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.03089080312664e-08 4.9025278742301e-07 1.67907289217333 0.6 20.1 20 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.03089080312664e-08 4.9025278742301e-07 1.67907289217333 0.6 20.1 20 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000394562180449615 0.0017065713762304 1.67907289217333 0.6 20.1 20 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00608502693862943 0.0176714149666728 1.67907289217333 0.6 20.1 20 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00608502693862943 0.0176714149666728 1.67907289217333 0.6 20.1 20 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00608502693862943 0.0176714149666728 1.67907289217333 0.6 20.1 20 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00608502693862943 0.0176714149666728 1.67907289217333 0.6 20.1 20 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.20561913666546e-08 4.22370002914347e-07 1.67004561855949 0.596774193548387 20.1 20 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 2.1697288989135e-05 0.000133082940653186 1.66394610936096 0.594594594594595 20.1 20 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000308136327703316 0.00137886161736421 1.65834359720823 0.592592592592593 20.1 20 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000308136327703316 0.00137886161736421 1.65834359720823 0.592592592592593 20.1 20 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 4.59737957125693e-06 3.3722016133498e-05 1.65363239380707 0.590909090909091 20.1 20 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 4.59737957125693e-06 3.3722016133498e-05 1.65363239380707 0.590909090909091 20.1 20 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00118491573409444 0.00456947178757828 1.65363239380707 0.590909090909091 20.1 20 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 4.38857874464839e-09 6.43809026147902e-08 1.64840489414277 0.589041095890411 20.1 20 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00465925389725081 0.0144964222313891 1.64614989428758 0.588235294117647 20.1 20 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00465925389725081 0.0144964222313891 1.64614989428758 0.588235294117647 20.1 20 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00465925389725081 0.0144964222313891 1.64614989428758 0.588235294117647 20.1 20 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00465925389725081 0.0144964222313891 1.64614989428758 0.588235294117647 20.1 20 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 9.58245903712449e-10 1.60421637762684e-08 1.64409220691972 0.5875 20.1 20 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.54379883260946e-12 1.22995749726909e-10 1.64140138497713 0.586538461538462 20.1 20 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.33612679563357e-05 8.66028716907488e-05 1.63811989480325 0.585365853658537 20.1 20 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.33612679563357e-05 8.66028716907488e-05 1.63811989480325 0.585365853658537 20.1 20 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 1.33612679563357e-05 8.66028716907488e-05 1.63811989480325 0.585365853658537 20.1 20 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 8.34333427384654e-15 5.39662030531074e-13 1.63243197850185 0.583333333333333 20.1 20 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000915660613814887 0.0035868539547608 1.63243197850185 0.583333333333333 20.1 20 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0190095264888304 0.0458484003281453 1.63243197850185 0.583333333333333 20.1 20 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0190095264888304 0.0458484003281453 1.63243197850185 0.583333333333333 20.1 20 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0190095264888304 0.0458484003281453 1.63243197850185 0.583333333333333 20.1 20 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 2.2212807654414e-06 1.76585616157716e-05 1.62310379576755 0.58 20.1 20 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00355963357642358 0.0115384022306395 1.62015805385146 0.578947368421053 20.1 20 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00355963357642358 0.0115384022306395 1.62015805385146 0.578947368421053 20.1 20 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 8.16091923560228e-06 5.55645362309189e-05 1.61688500727802 0.577777777777778 20.1 20 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00070609153169879 0.00282238272361623 1.61449316555128 0.576923076923077 20.1 20 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00070609153169879 0.00282238272361623 1.61449316555128 0.576923076923077 20.1 20 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00070609153169879 0.00282238272361623 1.61449316555128 0.576923076923077 20.1 20 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000144444689638233 0.000687440780452191 1.61123156319663 0.575757575757576 20.1 20 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.01205473695952e-05 0.000174945056762996 1.60911152166611 0.575 20.1 20 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.10832880387198e-10 1.99639479482256e-09 1.59911704016508 0.571428571428571 20.1 20 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 4.95497030676898e-06 3.56107209420821e-05 1.59911704016508 0.571428571428571 20.1 20 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000543655085922426 0.00226868383362936 1.59911704016507 0.571428571428571 20.1 20 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0142413882054492 0.0365912368229133 1.59911704016507 0.571428571428571 20.1 20 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0142413882054492 0.0365912368229133 1.59911704016507 0.571428571428571 20.1 20 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0142413882054492 0.0365912368229133 1.59911704016507 0.571428571428571 20.1 20 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0142413882054492 0.0365912368229133 1.59911704016507 0.571428571428571 20.1 20 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 8.68311689565669e-11 1.58411222339993e-09 1.59511924756466 0.57 20.1 20 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.8176862926287e-09 2.8739639937896e-08 1.59446844411808 0.569767441860465 20.1 20 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 7.18881622273028e-13 3.00873102498388e-11 1.59261656439205 0.569105691056911 20.1 20 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.81537150561009e-05 0.000113301475986103 1.59003114789141 0.568181818181818 20.1 20 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 8.64461830032822e-05 0.000428616440465751 1.5883121952991 0.567567567567568 20.1 20 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 8.64461830032822e-05 0.000428616440465751 1.5883121952991 0.567567567567568 20.1 20 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.4498978967778e-13 1.48763779003479e-11 1.58362172000844 0.565891472868217 20.1 20 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.07907156688254e-07 1.17215178601058e-06 1.58173533320676 0.565217391304348 20.1 20 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.07907156688254e-07 1.17215178601058e-06 1.58173533320676 0.565217391304348 20.1 20 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00207115753238388 0.00706776299420206 1.58173533320676 0.565217391304348 20.1 20 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 4.99630421425958e-07 4.26099885859601e-06 1.57977288242114 0.564516129032258 20.1 20 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0106842617551657 0.0287948948439408 1.5741308364125 0.5625 20.1 20 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0106842617551657 0.0287948948439408 1.5741308364125 0.5625 20.1 20 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0106842617551657 0.0287948948439408 1.5741308364125 0.5625 20.1 20 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.00515725445969e-13 4.76779591032046e-12 1.57035594232038 0.561151079136691 20.1 20 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 5.08276141810547e-08 6.12946567624075e-07 1.56713469936177 0.56 20.1 20 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00157887680173432 0.00571689997167415 1.56713469936177 0.56 20.1 20 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 4.49320495580446e-25 1.06563844201829e-22 1.5638423995732 0.558823529411765 20.1 20 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000246778941915281 0.00113279494950143 1.5638423995732 0.558823529411765 20.1 20 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 5.04294827449138e-06 3.58805769730062e-05 1.55469712238271 0.555555555555556 20.1 20 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00120353553669313 0.00461625624990384 1.55469712238271 0.555555555555556 20.1 20 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00120353553669313 0.00461625624990384 1.55469712238271 0.555555555555556 20.1 20 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000189452475382935 0.000886812080493147 1.55469712238271 0.555555555555556 20.1 20 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0599743124919617 0.121226486755769 1.55469712238271 0.555555555555556 20.1 20 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0599743124919617 0.121226486755769 1.55469712238271 0.555555555555556 20.1 20 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.84885295196292e-08 2.50563595299356e-07 1.55095086425649 0.55421686746988 20.1 20 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.56389875256535e-23 4.56053490612562e-21 1.54991343892923 0.553846153846154 20.1 20 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 5.03055381759754e-07 4.26099885859601e-06 1.54541534851774 0.552238805970149 20.1 20 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 5.03055381759754e-07 4.26099885859601e-06 1.54541534851774 0.552238805970149 20.1 20 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.16025166746056e-16 1.17931294485455e-14 1.54450238715397 0.551912568306011 20.1 20 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000917508671491869 0.0035868539547608 1.54397507326283 0.551724137931034 20.1 20 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000917508671491869 0.0035868539547608 1.54397507326283 0.551724137931034 20.1 20 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 6.56198588238852e-08 7.84681168961249e-07 1.542737913749 0.551282051282051 20.1 20 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.689084251852e-19 2.0029724086545e-17 1.53915015115888 0.55 20.1 20 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00604176965976747 0.0176714149666728 1.53915015115888 0.55 20.1 20 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00604176965976747 0.0176714149666728 1.53915015115888 0.55 20.1 20 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00604176965976747 0.0176714149666728 1.53915015115888 0.55 20.1 20 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000699590074288417 0.00282016055442611 1.53463651435197 0.548387096774194 20.1 20 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 8.55967449142338e-05 0.000428616440465751 1.53248716349153 0.547619047619048 20.1 20 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 8.55967449142338e-05 0.000428616440465751 1.53248716349153 0.547619047619048 20.1 20 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.35592409263715e-08 3.16271696587044e-07 1.5293880994602 0.546511627906977 20.1 20 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000533562847825317 0.00225299683221195 1.52642990197575 0.545454545454545 20.1 20 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00455360835048737 0.0143041604475575 1.52642990197575 0.545454545454545 20.1 20 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0435975140043214 0.0930123874484998 1.52642990197575 0.545454545454545 20.1 20 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 8.29171685675291e-08 9.59277486760926e-07 1.52014829744087 0.54320987654321 20.1 20 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 7.31602239100653e-19 8.00823066338638e-17 1.5184440953137 0.542600896860987 20.1 20 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.92739998223827e-15 2.3142723192917e-13 1.51780600422448 0.542372881355932 20.1 20 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.91881995791203e-06 3.55303593914153e-05 1.51780600422448 0.542372881355932 20.1 20 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.91881995791203e-06 3.55303593914153e-05 1.51780600422448 0.542372881355932 20.1 20 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.91881995791203e-06 3.55303593914153e-05 1.51780600422448 0.542372881355932 20.1 20 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.89979493017864e-07 4.22570193069346e-06 1.51582969432314 0.541666666666667 20.1 20 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 3.86442324824481e-05 0.000214807589150483 1.51582969432314 0.541666666666667 20.1 20 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00343674479978359 0.0111910477118811 1.51582969432314 0.541666666666667 20.1 20 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00343674479978359 0.0111910477118811 1.51582969432314 0.541666666666667 20.1 20 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.78515143817042e-06 2.85626066245182e-05 1.51391818146776 0.540983606557377 20.1 20 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.78515143817042e-06 2.85626066245182e-05 1.51391818146776 0.540983606557377 20.1 20 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 2.96460100647186e-05 0.000172894558697109 1.511165602956 0.54 20.1 20 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.91254399768818e-06 2.24029735605961e-05 1.51027720460035 0.53968253968254 20.1 20 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 4.23779829108753e-12 1.38182956511646e-10 1.50995763684652 0.539568345323741 20.1 20 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 2.27440065071999e-05 0.000136560005315382 1.50686028784786 0.538461538461538 20.1 20 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00259712628344244 0.00863483808723971 1.50686028784786 0.538461538461538 20.1 20 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00259712628344244 0.00863483808723971 1.50686028784786 0.538461538461538 20.1 20 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00259712628344244 0.00863483808723971 1.50686028784786 0.538461538461538 20.1 20 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0319517173696842 0.0708440561160152 1.50686028784786 0.538461538461538 20.1 20 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0319517173696842 0.0708440561160152 1.50686028784786 0.538461538461538 20.1 20 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0319517173696842 0.0708440561160152 1.50686028784786 0.538461538461538 20.1 20 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0319517173696842 0.0708440561160152 1.50686028784786 0.538461538461538 20.1 20 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.33374084685161e-07 1.42700242486455e-06 1.50160990356964 0.536585365853659 20.1 20 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.000181079230921528 0.000850415001984601 1.50160990356964 0.536585365853659 20.1 20 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000181079230921528 0.000850415001984601 1.50160990356964 0.536585365853659 20.1 20 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.06951486667007e-09 1.76198744708366e-08 1.50098940360949 0.536363636363636 20.1 20 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.33890595727089e-05 8.66028716907488e-05 1.49917222515476 0.535714285714286 20.1 20 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00196493605681318 0.00677022762432239 1.49917222515476 0.535714285714286 20.1 20 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000138320087174486 0.000664964473139506 1.49684792713126 0.534883720930233 20.1 20 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0235629439389575 0.0546092332656946 1.4925092374874 0.533333333333333 20.1 20 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0235629439389575 0.0546092332656946 1.4925092374874 0.533333333333333 20.1 20 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0235629439389575 0.0546092332656946 1.4925092374874 0.533333333333333 20.1 20 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.20168665528272e-09 3.36881732308313e-08 1.48908605116289 0.532110091743119 20.1 20 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.62799457938895e-07 1.69097539158429e-06 1.48153490485882 0.529411764705882 20.1 20 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.62799457938895e-07 1.69097539158429e-06 1.48153490485882 0.529411764705882 20.1 20 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.73700967511304e-06 2.11671998243796e-05 1.48153490485882 0.529411764705882 20.1 20 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000856194741974106 0.00340325451907584 1.48153490485882 0.529411764705882 20.1 20 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0174623955953199 0.0433664728309602 1.48153490485882 0.529411764705882 20.1 20 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0174623955953199 0.0433664728309602 1.48153490485882 0.529411764705882 20.1 20 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0174623955953199 0.0433664728309602 1.48153490485882 0.529411764705882 20.1 20 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0174623955953199 0.0433664728309602 1.48153490485882 0.529411764705882 20.1 20 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0174623955953199 0.0433664728309602 1.48153490485882 0.529411764705882 20.1 20 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.7563282614694e-12 6.75474355694851e-11 1.48047287266896 0.529032258064516 20.1 20 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.04591603175188e-12 4.25239575195121e-11 1.47842896166205 0.528301886792453 20.1 20 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 2.76512904401451e-05 0.000162594158249283 1.47554890524323 0.527272727272727 20.1 20 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.62221179509151e-12 1.4616460854256e-10 1.47287095804678 0.526315789473684 20.1 20 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0129931975160911 0.0339756240688861 1.47287095804678 0.526315789473684 20.1 20 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0129931975160911 0.0339756240688861 1.47287095804678 0.526315789473684 20.1 20 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0129931975160911 0.0339756240688861 1.47287095804678 0.526315789473684 20.1 20 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000375914104356345 0.00164592544768948 1.46918878065166 0.525 20.1 20 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.64612773185192e-14 2.27980681462941e-12 1.46804187293843 0.524590163934426 20.1 20 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.23869842139116e-10 1.22626998257615e-08 1.46804187293843 0.524590163934426 20.1 20 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.24077095727805e-05 8.25054706638627e-05 1.46804187293843 0.524590163934426 20.1 20 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00969996266981132 0.0267500908510494 1.46585728681799 0.523809523809524 20.1 20 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00969996266981132 0.0267500908510494 1.46585728681799 0.523809523809524 20.1 20 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 7.86944148893067e-16 6.58718543455785e-14 1.46585728681799 0.523809523809524 20.1 20 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 7.01370136517933e-09 9.98049704265019e-08 1.46341215372905 0.522935779816514 20.1 20 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.27269858504034e-12 1.38182956511646e-10 1.46161334562859 0.522292993630573 20.1 20 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 6.91066022205393e-11 1.29393019683984e-09 1.45919429915063 0.521428571428571 20.1 20 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.91066022205393e-11 1.29393019683984e-09 1.45919429915063 0.521428571428571 20.1 20 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.51291620851598e-06 1.98659986928791e-05 1.45672990645175 0.520547945205479 20.1 20 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.12193046380328e-09 1.81421255680917e-08 1.45610657315844 0.520325203252033 20.1 20 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00544943513100361 0.0163598020915994 1.45519650655022 0.52 20.1 20 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.08009941722915e-12 1.57151771102545e-10 1.45169843802486 0.51875 20.1 20 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 5.62593743755428e-05 0.000306732144583898 1.4510506475572 0.518518518518518 20.1 20 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 5.62593743755428e-05 0.000306732144583898 1.4510506475572 0.518518518518518 20.1 20 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00409791631840326 0.0130163725917139 1.4510506475572 0.518518518518518 20.1 20 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00409791631840326 0.0130163725917139 1.4510506475572 0.518518518518518 20.1 20 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00409791631840326 0.0130163725917139 1.4510506475572 0.518518518518518 20.1 20 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 3.28322919016914e-05 0.000186136858072139 1.4474766311839 0.517241379310345 20.1 20 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.50953377192473e-05 0.000148177035578792 1.44586832381592 0.516666666666667 20.1 20 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.46760232184876e-05 9.44976517642892e-05 1.44295326671145 0.515625 20.1 20 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00176020829595148 0.00626194101284741 1.44162824075488 0.515151515151515 20.1 20 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00176020829595148 0.00626194101284741 1.44162824075488 0.515151515151515 20.1 20 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.65146551215854e-08 4.72366856709237e-07 1.43920533614857 0.514285714285714 20.1 20 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 6.57799190945299e-06 4.58847180742726e-05 1.43920533614857 0.514285714285714 20.1 20 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 3.85756081448075e-06 2.87398379005556e-05 1.43704436717537 0.513513513513513 20.1 20 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 3.85756081448075e-06 2.87398379005556e-05 1.43704436717537 0.513513513513513 20.1 20 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000580490721462901 0.0023943139033093 1.43335490795284 0.51219512195122 20.1 20 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000580490721462901 0.0023943139033093 1.43335490795284 0.51219512195122 20.1 20 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000580490721462901 0.0023943139033093 1.43335490795284 0.51219512195122 20.1 20 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000580490721462901 0.0023943139033093 1.43335490795284 0.51219512195122 20.1 20 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.01943109043451e-09 3.15785762822891e-08 1.4322800261321 0.511811023622047 20.1 20 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.26810743957241e-08 4.26652925368032e-07 1.4246679085107 0.509090909090909 20.1 20 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 8.59270169752146e-05 0.000428616440465751 1.4246679085107 0.509090909090909 20.1 20 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 8.59270169752146e-05 0.000428616440465751 1.4246679085107 0.509090909090909 20.1 20 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 8.59270169752146e-05 0.000428616440465751 1.4246679085107 0.509090909090909 20.1 20 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 8.59270169752146e-05 0.000428616440465751 1.4246679085107 0.509090909090909 20.1 20 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 8.59270169752146e-05 0.000428616440465751 1.4246679085107 0.509090909090909 20.1 20 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.23024689445001e-05 0.000135048567268186 1.42075398568512 0.507692307692308 20.1 20 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.23024689445001e-05 0.000135048567268186 1.42075398568512 0.507692307692308 20.1 20 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.30372984086282e-05 8.58892390531388e-05 1.41950606826248 0.507246376811594 20.1 20 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.42387665438851e-06 2.61944971999723e-05 1.41693914951336 0.506329113924051 20.1 20 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.9494007842823e-09 8.63877277146298e-08 1.410244948807 0.503937007874016 20.1 20 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 6.79857381068962e-09 9.77209144708215e-08 1.39922741014444 0.5 20.1 20 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000874871477396247 0.00345100135569533 1.39922741014444 0.5 20.1 20 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000874871477396247 0.00345100135569533 1.39922741014444 0.5 20.1 20 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00266422184992885 0.00881671556383432 1.39922741014444 0.5 20.1 20 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00266422184992885 0.00881671556383432 1.39922741014444 0.5 20.1 20 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00830174397856483 0.0232090013388954 1.39922741014444 0.5 20.1 20 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00830174397856483 0.0232090013388954 1.39922741014444 0.5 20.1 20 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0364416261227493 0.0792911834444531 1.39922741014444 0.5 20.1 20 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0364416261227493 0.0792911834444531 1.39922741014444 0.5 20.1 20 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0364416261227493 0.0792911834444531 1.39922741014444 0.5 20.1 20 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 7.30765568331461e-08 8.59404465897247e-07 1.39922741014444 0.5 20.1 20 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 8.7255395898568e-06 5.91259182684106e-05 1.39922741014444 0.5 20.1 20 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.49086179006652e-05 9.52587937023442e-05 1.39922741014444 0.5 20.1 20 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 7.49746360232229e-05 0.00039080185736647 1.39922741014444 0.5 20.1 20 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 9.82767389740991e-05 0.000485582637361608 1.39922741014444 0.5 20.1 20 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000383401942763901 0.00167356124096022 1.39922741014444 0.5 20.1 20 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00152325333714031 0.00557995554992021 1.39922741014444 0.5 20.1 20 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00201325518781145 0.00688668781792234 1.39922741014444 0.5 20.1 20 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00201325518781145 0.00688668781792234 1.39922741014444 0.5 20.1 20 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00468612384148909 0.0144964222313891 1.39922741014444 0.5 20.1 20 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00468612384148909 0.0144964222313891 1.39922741014444 0.5 20.1 20 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00468612384148909 0.0144964222313891 1.39922741014444 0.5 20.1 20 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00623089657999332 0.0180214752709969 1.39922741014444 0.5 20.1 20 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00623089657999332 0.0180214752709969 1.39922741014444 0.5 20.1 20 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0110867282315987 0.0297668193840849 1.39922741014444 0.5 20.1 20 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0110867282315987 0.0297668193840849 1.39922741014444 0.5 20.1 20 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0148463169891352 0.0379287416077908 1.39922741014444 0.5 20.1 20 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0148463169891352 0.0379287416077908 1.39922741014444 0.5 20.1 20 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0148463169891352 0.0379287416077908 1.39922741014444 0.5 20.1 20 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0199446253724148 0.0476994989999096 1.39922741014444 0.5 20.1 20 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0199446253724148 0.0476994989999096 1.39922741014444 0.5 20.1 20 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0268966273270053 0.0606559440353859 1.39922741014444 0.5 20.1 20 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0268966273270053 0.0606559440353859 1.39922741014444 0.5 20.1 20 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0268966273270053 0.0606559440353859 1.39922741014444 0.5 20.1 20 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0268966273270053 0.0606559440353859 1.39922741014444 0.5 20.1 20 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0496620465339192 0.103166557982142 1.39922741014444 0.5 20.1 20 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0496620465339192 0.103166557982142 1.39922741014444 0.5 20.1 20 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0496620465339192 0.103166557982142 1.39922741014444 0.5 20.1 20 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0496620465339192 0.103166557982142 1.39922741014444 0.5 20.1 20 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0496620465339192 0.103166557982142 1.39922741014444 0.5 20.1 20 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0496620465339192 0.103166557982142 1.39922741014444 0.5 20.1 20 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0681855015198123 0.136084107521308 1.39922741014444 0.5 20.1 20 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0945529916047641 0.177974744779867 1.39922741014444 0.5 20.1 20 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0945529916047641 0.177974744779867 1.39922741014444 0.5 20.1 20 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0945529916047641 0.177974744779867 1.39922741014444 0.5 20.1 20 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0945529916047641 0.177974744779867 1.39922741014444 0.5 20.1 20 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0945529916047641 0.177974744779867 1.39922741014444 0.5 20.1 20 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00029166376313087 0.0013134099206811 1.39922741014444 0.5 20.1 20 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000504355098153358 0.00213600388295306 1.39922741014444 0.5 20.1 20 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000504355098153358 0.00213600388295306 1.39922741014444 0.5 20.1 20 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 6.87993425147533e-07 5.79298605908248e-06 1.38509379994096 0.494949494949495 20.1 20 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.87924185698318e-21 2.67416116248706e-19 1.37677991158597 0.491978609625668 20.1 20 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000327309326843149 0.00144198505293437 1.3728268929719 0.490566037735849 20.1 20 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.00074332538772249 0.00296289083117396 1.36945661418392 0.48936170212766 20.1 20 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00128908122400485 0.0048656832407398 1.3666872378155 0.488372093023256 20.1 20 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00224372272480756 0.00760194627952655 1.3633497842433 0.487179487179487 20.1 20 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.45011964370275e-05 0.000145271677207875 1.36240563619327 0.486842105263158 20.1 20 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.45011964370275e-05 0.000145271677207875 1.36240563619327 0.486842105263158 20.1 20 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0039226623040463 0.0126574794980904 1.35924948414031 0.485714285714286 20.1 20 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000122612030423939 0.000593458909160766 1.35550155357743 0.484375 20.1 20 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000160557551914581 0.000761577987914827 1.35409104207527 0.483870967741935 20.1 20 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00689549868477901 0.019822817431193 1.35409104207527 0.483870967741935 20.1 20 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.18511064178969e-10 2.10801555408342e-09 1.35360042937886 0.483695652173913 20.1 20 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000275666008975795 0.00125326751045545 1.35097818910498 0.482758620689655 20.1 20 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000275666008975795 0.00125326751045545 1.35097818910498 0.482758620689655 20.1 20 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000275666008975795 0.00125326751045545 1.35097818910498 0.482758620689655 20.1 20 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0122052982344291 0.0325856273688417 1.34740417273168 0.481481481481481 20.1 20 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.54784180810804e-09 5.25893634681014e-08 1.34609219203769 0.481012658227848 20.1 20 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.71902522627999e-06 2.11430212950624e-05 1.34325831373866 0.48 20.1 20 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0162903834013788 0.0409562112723712 1.34325831373866 0.48 20.1 20 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0162903834013788 0.0409562112723712 1.34325831373866 0.48 20.1 20 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0162903834013788 0.0409562112723712 1.34325831373866 0.48 20.1 20 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0010744549570844 0.00416607467011198 1.34092626805509 0.479166666666667 20.1 20 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 7.85969574631976e-05 0.000408187848431132 1.34010512520876 0.47887323943662 20.1 20 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00141308059708961 0.00530557701756863 1.33839143579033 0.478260869565217 20.1 20 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00141308059708961 0.00530557701756863 1.33839143579033 0.478260869565217 20.1 20 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00185982429540723 0.00651910257278585 1.33562616422878 0.477272727272727 20.1 20 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.75334418829517e-06 1.40960948019437e-05 1.33384295172648 0.476635514018692 20.1 20 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.91201845954639e-14 1.18295750779761e-12 1.33355969775499 0.476534296028881 20.1 20 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.000229804294204776 0.00105828967848995 1.3325975334709 0.476190476190476 20.1 20 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.42073763673767e-10 5.93623128911915e-09 1.33188491446904 0.475935828877005 20.1 20 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.03841026909123e-07 3.02353693210966e-06 1.33152285804068 0.475806451612903 20.1 20 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.03841026909123e-07 3.02353693210966e-06 1.33152285804068 0.475806451612903 20.1 20 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.03841026909123e-07 3.02353693210966e-06 1.33152285804068 0.475806451612903 20.1 20 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.94789452483197e-05 0.000172627732873905 1.33097241452764 0.475609756097561 20.1 20 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00322982979383001 0.0105899718816132 1.32926603963722 0.475 20.1 20 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00322982979383001 0.0105899718816132 1.32926603963722 0.475 20.1 20 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.20379830704388e-08 1.66311164167324e-07 1.32747215834216 0.474358974358974 20.1 20 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.17309396847758e-42 4.5153127171436e-39 1.32641693405095 0.473981900452489 20.1 20 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.50617662596867e-07 1.58762173240994e-06 1.3255838622421 0.473684210526316 20.1 20 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00426237884712484 0.0134785891099081 1.3255838622421 0.473684210526316 20.1 20 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00563107919751962 0.0166938035376467 1.32149255402531 0.472222222222222 20.1 20 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.7602632256453e-25 5.00970914018652e-23 1.32061912867565 0.471910112359551 20.1 20 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.88067278441212e-05 0.000116864514070675 1.32061912867565 0.471910112359551 20.1 20 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.35308807002218e-20 1.75040393058324e-18 1.32039769689687 0.471830985915493 20.1 20 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 7.10453254400085e-11 1.31295452079392e-09 1.31927155813619 0.471428571428571 20.1 20 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.19016832705938e-05 0.00018158438117622 1.31691991543006 0.470588235294118 20.1 20 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.19016832705938e-05 0.00018158438117622 1.31691991543006 0.470588235294118 20.1 20 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.19016832705938e-05 0.00018158438117622 1.31691991543006 0.470588235294118 20.1 20 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.19016832705938e-05 0.00018158438117622 1.31691991543006 0.470588235294118 20.1 20 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.19016832705938e-05 0.00018158438117622 1.31691991543006 0.470588235294118 20.1 20 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00116207676794812 0.00449357402388636 1.31691991543006 0.470588235294118 20.1 20 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00744813065419584 0.0212398595609633 1.31691991543006 0.470588235294118 20.1 20 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00744813065419584 0.0212398595609633 1.31691991543006 0.470588235294118 20.1 20 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00744813065419584 0.0212398595609633 1.31691991543006 0.470588235294118 20.1 20 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.0533120532582422 0.110106025814918 1.31691991543006 0.470588235294118 20.1 20 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0533120532582422 0.110106025814918 1.31691991543006 0.470588235294118 20.1 20 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0533120532582422 0.110106025814918 1.31691991543006 0.470588235294118 20.1 20 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0533120532582422 0.110106025814918 1.31691991543006 0.470588235294118 20.1 20 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00152501999089064 0.00557995554992021 1.31356042584988 0.469387755102041 20.1 20 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00152501999089064 0.00557995554992021 1.31356042584988 0.469387755102041 20.1 20 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00986451401032152 0.0271512639007496 1.31177569701041 0.46875 20.1 20 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.0438556811284e-07 1.15147801104319e-06 1.31116414656892 0.468531468531469 20.1 20 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.02441812190367e-05 0.000124707661795191 1.30797344861328 0.467391304347826 20.1 20 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.50438345836529e-06 3.33840503190302e-05 1.30768916835929 0.467289719626168 20.1 20 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0130840772942724 0.0339756240688861 1.30594558280148 0.466666666666667 20.1 20 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0130840772942724 0.0339756240688861 1.30594558280148 0.466666666666667 20.1 20 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0724987613045108 0.141906103626298 1.30594558280148 0.466666666666667 20.1 20 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0724987613045108 0.141906103626298 1.30594558280148 0.466666666666667 20.1 20 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0724987613045108 0.141906103626298 1.30594558280148 0.466666666666667 20.1 20 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0724987613045108 0.141906103626298 1.30594558280148 0.466666666666667 20.1 20 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0724987613045108 0.141906103626298 1.30594558280148 0.466666666666667 20.1 20 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 5.29229893068835e-11 1.0316358052561e-09 1.3051089744845 0.466367713004484 20.1 20 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 3.42554674516457e-05 0.00019115894189683 1.30382554127096 0.465909090909091 20.1 20 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.28243512720677e-05 8.48793109774525e-05 1.30029213872009 0.464646464646465 20.1 20 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0173831130016068 0.0433664728309602 1.29928259513412 0.464285714285714 20.1 20 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.44884033565134e-12 8.93512768623555e-11 1.29736794350557 0.46360153256705 20.1 20 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00455118638624842 0.0143041604475575 1.29684491671924 0.463414634146341 20.1 20 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00455118638624842 0.0143041604475575 1.29684491671924 0.463414634146341 20.1 20 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.53151929031883e-15 3.74826283339224e-13 1.29621680326264 0.46319018404908 20.1 20 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.91577461438617e-23 7.77238586252391e-21 1.29282228389772 0.461977186311787 20.1 20 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.05271135725152e-05 7.09956521975789e-05 1.29159453244102 0.461538461538462 20.1 20 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0016246070811875 0.00585269842159447 1.29159453244102 0.461538461538462 20.1 20 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0231377886209337 0.0538871901924529 1.29159453244102 0.461538461538462 20.1 20 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0231377886209337 0.0538871901924529 1.29159453244102 0.461538461538462 20.1 20 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0231377886209337 0.0538871901924529 1.29159453244102 0.461538461538462 20.1 20 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0992430307913507 0.184605010217114 1.29159453244102 0.461538461538462 20.1 20 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0992430307913507 0.184605010217114 1.29159453244102 0.461538461538462 20.1 20 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0992430307913507 0.184605010217114 1.29159453244102 0.461538461538462 20.1 20 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0992430307913507 0.184605010217114 1.29159453244102 0.461538461538462 20.1 20 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0992430307913507 0.184605010217114 1.29159453244102 0.461538461538462 20.1 20 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0992430307913507 0.184605010217114 1.29159453244102 0.461538461538462 20.1 20 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 6.16473981166794e-05 0.000331034896302018 1.28664589438569 0.459770114942529 20.1 20 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 6.16473981166794e-05 0.000331034896302018 1.28664589438569 0.459770114942529 20.1 20 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00278770460185045 0.00920395278058745 1.28262512596574 0.458333333333333 20.1 20 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0308629513544177 0.0691621728776952 1.28262512596574 0.458333333333333 20.1 20 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0104169461069534 0.0282348844003707 1.27929363213206 0.457142857142857 20.1 20 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0104169461069534 0.0282348844003707 1.27929363213206 0.457142857142857 20.1 20 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00365406499046631 0.0118175783668945 1.27755546143623 0.456521739130435 20.1 20 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.02822883294426e-06 4.87861933135594e-05 1.27648816364054 0.456140350877193 20.1 20 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0137542094754329 0.0356507105346832 1.27202491831313 0.454545454545455 20.1 20 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.137015889605133 0.236618459839932 1.27202491831313 0.454545454545455 20.1 20 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.4038616832562e-12 5.54915326464881e-11 1.27028836552362 0.453924914675768 20.1 20 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.36806927078954e-08 8.59406768224058e-07 1.26753541860143 0.452941176470588 20.1 20 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00223588157710021 0.00759345938953125 1.26722482428176 0.452830188679245 20.1 20 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.000142117831551908 0.000678636490934111 1.26596765679735 0.452380952380952 20.1 20 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.000142117831551908 0.000678636490934111 1.26596765679735 0.452380952380952 20.1 20 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 6.83887700377962e-05 0.000358169006049795 1.26381830593691 0.451612903225806 20.1 20 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.000500447229327953 0.00213600388295306 1.26127541196119 0.450704225352113 20.1 20 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00825314930213323 0.0231641646093404 1.25930466913 0.45 20.1 20 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.28379007531392e-07 1.38396460391796e-06 1.25847672391689 0.449704142011834 20.1 20 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.74374786175181e-07 2.80888719947685e-06 1.25329571706189 0.447852760736196 20.1 20 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.91897740042351e-29 1.39417621020066e-26 1.25052590560924 0.446862996158771 20.1 20 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00652060235515586 0.0188211301245168 1.24375769790617 0.444444444444444 20.1 20 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0318837809301374 0.0708440561160152 1.24375769790617 0.444444444444444 20.1 20 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0318837809301374 0.0708440561160152 1.24375769790617 0.444444444444444 20.1 20 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000322107876681643 0.00142347673452788 1.24375769790617 0.444444444444444 20.1 20 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0142456396345003 0.0365912368229133 1.24375769790617 0.444444444444444 20.1 20 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0744443940032317 0.144719088342348 1.24375769790617 0.444444444444444 20.1 20 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0744443940032317 0.144719088342348 1.24375769790617 0.444444444444444 20.1 20 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0744443940032317 0.144719088342348 1.24375769790617 0.444444444444444 20.1 20 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000199477768159723 0.000927636810755838 1.2402242953553 0.443181818181818 20.1 20 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000875482424037957 0.00345100135569533 1.23931570612793 0.442857142857143 20.1 20 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.00012372887061172 0.000596834518238905 1.2372116047593 0.442105263157895 20.1 20 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.00852592042007467 0.0237889897211103 1.23652654849974 0.441860465116279 20.1 20 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 9.90505397562811e-05 0.00048603075197651 1.23132012092711 0.44 20.1 20 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 9.90505397562811e-05 0.00048603075197651 1.23132012092711 0.44 20.1 20 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.33401989722576e-06 1.07858540554105e-05 1.22989415668747 0.439490445859873 20.1 20 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.0111503376710865 0.0298812250582978 1.22858992110244 0.439024390243902 20.1 20 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.100543199779214 0.186292933965913 1.22432398387639 0.4375 20.1 20 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00405367389352406 0.012962647079741 1.2211439215806 0.436363636363636 20.1 20 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.44862522618865e-05 0.000145271677207875 1.21868193786774 0.435483870967742 20.1 20 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 6.29956010977375e-33 4.48213701810402e-30 1.21854639321888 0.435435435435435 20.1 20 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 8.13344987327451e-05 0.000420869060715259 1.21784607919979 0.435185185185185 20.1 20 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00194732625552893 0.00675864697955528 1.21127148937877 0.432835820895522 20.1 20 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.00194732625552893 0.00675864697955528 1.21127148937877 0.432835820895522 20.1 20 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0190824447469767 0.0459463940354447 1.21014262498979 0.432432432432432 20.1 20 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.84106988511431e-07 2.88774460465548e-06 1.20974869835405 0.432291666666667 20.1 20 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 3.79362800564578e-06 2.85626066245182e-05 1.2096546642539 0.432258064516129 20.1 20 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.000278494338497923 0.00125808712280173 1.20775418559836 0.431578947368421 20.1 20 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.000278494338497923 0.00125808712280173 1.20775418559836 0.431578947368421 20.1 20 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.30594422437635e-16 4.0849057541917e-14 1.20583825589684 0.430894308943089 20.1 20 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.0015371346279471 0.00557995554992021 1.2048902698466 0.430555555555556 20.1 20 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.0015371346279471 0.00557995554992021 1.2048902698466 0.430555555555556 20.1 20 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0015371346279471 0.00557995554992021 1.2048902698466 0.430555555555556 20.1 20 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0748940014801363 0.144801853405209 1.19933778012381 0.428571428571429 20.1 20 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0748940014801363 0.144801853405209 1.19933778012381 0.428571428571429 20.1 20 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0748940014801363 0.144801853405209 1.19933778012381 0.428571428571429 20.1 20 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.48077285875404e-07 1.57249237164702e-06 1.19933778012381 0.428571428571429 20.1 20 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0249695027416596 0.0577284126174818 1.19933778012381 0.428571428571429 20.1 20 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0427592818765354 0.0924785807108314 1.19933778012381 0.428571428571429 20.1 20 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.136428768984424 0.236618459839932 1.19933778012381 0.428571428571429 20.1 20 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.136428768984424 0.236618459839932 1.19933778012381 0.428571428571429 20.1 20 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.136428768984424 0.236618459839932 1.19933778012381 0.428571428571429 20.1 20 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.136428768984424 0.236618459839932 1.19933778012381 0.428571428571429 20.1 20 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.136428768984424 0.236618459839932 1.19933778012381 0.428571428571429 20.1 20 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.136428768984424 0.236618459839932 1.19933778012381 0.428571428571429 20.1 20 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.136428768984424 0.236618459839932 1.19933778012381 0.428571428571429 20.1 20 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 6.74880642338567e-05 0.000357009350947131 1.19933778012381 0.428571428571429 20.1 20 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.33550218899988e-05 0.000187605518377345 1.19628603004716 0.427480916030534 20.1 20 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.33550218899988e-05 0.000187605518377345 1.19628603004716 0.427480916030534 20.1 20 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0192659752718005 0.0462318428529042 1.18934329862277 0.425 20.1 20 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00200592432783453 0.00688668781792234 1.18838492368432 0.424657534246575 20.1 20 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0326760191468363 0.072089884102245 1.18722325709225 0.424242424242424 20.1 20 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.000180297363590454 0.000850415001984601 1.1849313203025 0.423423423423423 20.1 20 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00894224439423302 0.0248047052105138 1.1839616547376 0.423076923076923 20.1 20 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00894224439423302 0.0248047052105138 1.1839616547376 0.423076923076923 20.1 20 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0563745203807305 0.115425816549323 1.1839616547376 0.423076923076923 20.1 20 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.000112967941273142 0.000548646349596183 1.17951401516308 0.421487603305785 20.1 20 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0250770119837341 0.0577284126174818 1.17829676643742 0.421052631578947 20.1 20 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0250770119837341 0.0577284126174818 1.17829676643742 0.421052631578947 20.1 20 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0999241611642526 0.185629349003566 1.17829676643742 0.421052631578947 20.1 20 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000976848063226758 0.00380836929855254 1.17662304943964 0.420454545454545 20.1 20 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00330896322206598 0.0108244934827584 1.17616217084605 0.420289855072464 20.1 20 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0427624076653036 0.0924785807108314 1.17354556979856 0.419354838709677 20.1 20 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00897523151140822 0.0248477712854745 1.17026292484808 0.418181818181818 20.1 20 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 7.49489429912382e-16 6.58718543455785e-14 1.16643125609239 0.416812609457093 20.1 20 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.186180452523219 0.307316371388182 1.16602284178703 0.416666666666667 20.1 20 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.186180452523219 0.307316371388182 1.16602284178703 0.416666666666667 20.1 20 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.186180452523219 0.307316371388182 1.16602284178703 0.416666666666667 20.1 20 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.186180452523219 0.307316371388182 1.16602284178703 0.416666666666667 20.1 20 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.186180452523219 0.307316371388182 1.16602284178703 0.416666666666667 20.1 20 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.00793931414527e-12 7.51920432639137e-11 1.16079403980593 0.414798206278027 20.1 20 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.75126128908388e-05 0.000110267469662229 1.16033492548563 0.414634146341463 20.1 20 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00424829161381342 0.0134639620633775 1.15935985411968 0.414285714285714 20.1 20 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.0015967083441533 0.00576679181149783 1.15798130494712 0.413793103448276 20.1 20 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0559585607084453 0.114904807919362 1.15798130494712 0.413793103448276 20.1 20 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0559585607084453 0.114904807919362 1.15798130494712 0.413793103448276 20.1 20 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0192500834367616 0.0462318428529042 1.15588351272802 0.41304347826087 20.1 20 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0424363476208719 0.0920532357690561 1.1523049260013 0.411764705882353 20.1 20 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.133605002343894 0.236173811596723 1.1523049260013 0.411764705882353 20.1 20 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.133605002343894 0.236173811596723 1.1523049260013 0.411764705882353 20.1 20 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0323754382439376 0.07153765313839 1.14808402883646 0.41025641025641 20.1 20 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0323754382439376 0.07153765313839 1.14808402883646 0.41025641025641 20.1 20 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0981737808305855 0.184059670779872 1.14482242648182 0.409090909090909 20.1 20 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0732119037530131 0.14290883270307 1.14011122308066 0.407407407407407 20.1 20 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0732119037530131 0.14290883270307 1.14011122308066 0.407407407407407 20.1 20 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.00257231360614061 0.00861271120361903 1.13890603151292 0.406976744186047 20.1 20 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0114102611718786 0.0305203038488406 1.13835450316836 0.406779661016949 20.1 20 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00885199555153406 0.0246504690211995 1.13687227074236 0.40625 20.1 20 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0418659687433878 0.0909546160638791 1.13450871092793 0.405405405405405 20.1 20 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0319619705035009 0.0708440561160152 1.13270790345026 0.404761904761905 20.1 20 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.05408091087368 0.111532081410502 1.11938192811555 0.4 20.1 20 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.129649804680735 0.23177345736267 1.11938192811555 0.4 20.1 20 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.179048774104367 0.298344737178587 1.11938192811555 0.4 20.1 20 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.179048774104367 0.298344737178587 1.11938192811555 0.4 20.1 20 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.179048774104367 0.298344737178587 1.11938192811555 0.4 20.1 20 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.179048774104367 0.298344737178587 1.11938192811555 0.4 20.1 20 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.35253088351942e-32 6.41550482416045e-30 1.11468471537653 0.398321497740478 20.1 20 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0307986846775605 0.0691270162400136 1.10772169969768 0.395833333333333 20.1 20 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 7.54984341070593e-06 5.21471009547718e-05 1.10496928526428 0.394849785407725 20.1 20 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0697681129249861 0.137506959407556 1.10242159587138 0.393939393939394 20.1 20 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 2.49845736804415e-13 1.14687252733123e-11 1.10110275199547 0.393468118195956 20.1 20 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0929165414377929 0.176058906079866 1.09939296511349 0.392857142857143 20.1 20 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00818759710671842 0.0230255942349018 1.09812784087285 0.392405063291139 20.1 20 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.00783737225904956 0.0222606401689172 1.0864589302298 0.388235294117647 20.1 20 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.00783737225904956 0.0222606401689172 1.0864589302298 0.388235294117647 20.1 20 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.089859458933434 0.170493346749702 1.08327283366021 0.387096774193548 20.1 20 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0166421949375642 0.0417669195699364 1.07940400211143 0.385714285714286 20.1 20 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.50620018151985e-05 9.52587937023442e-05 1.07718300622231 0.384920634920635 20.1 20 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.50620018151985e-05 9.52587937023442e-05 1.07718300622231 0.384920634920635 20.1 20 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.50620018151985e-05 9.52587937023442e-05 1.07718300622231 0.384920634920635 20.1 20 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00727327953778238 0.0208666870610168 1.07174865457872 0.382978723404255 20.1 20 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.012261574057862 0.0326745690717932 1.07101357319698 0.382716049382716 20.1 20 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.115501974105728 0.211980250966979 1.0614828628682 0.379310344827586 20.1 20 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0261206049869474 0.0592816920198183 1.06002076526094 0.378787878787879 20.1 20 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0337459663836599 0.0741053870999728 1.0551550961745 0.377049180327869 20.1 20 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00215695245415614 0.00734292665613442 1.05190145727171 0.375886524822695 20.1 20 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.110681488704247 0.204279842316659 1.04942055760833 0.375 20.1 20 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.110681488704247 0.204279842316659 1.04942055760833 0.375 20.1 20 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.226152118699458 0.360778548104629 1.04942055760833 0.375 20.1 20 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.226152118699458 0.360778548104629 1.04942055760833 0.375 20.1 20 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.226152118699458 0.360778548104629 1.04942055760833 0.375 20.1 20 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.226152118699458 0.360778548104629 1.04942055760833 0.375 20.1 20 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.000432701155372824 0.00186585983059251 1.04942055760833 0.375 20.1 20 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0589671388329608 0.119530254357982 1.04942055760833 0.375 20.1 20 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.155582537334752 0.267061460346624 1.04942055760833 0.375 20.1 20 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.155582537334752 0.267061460346624 1.04942055760833 0.375 20.1 20 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.155582537334752 0.267061460346624 1.04942055760833 0.375 20.1 20 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.148083342336241 0.25511210186982 1.03646474825514 0.37037037037037 20.1 20 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0969228662833394 0.182194502934203 1.02382493425203 0.365853658536585 20.1 20 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0485108939261187 0.101665687859892 1.02165810899435 0.365079365079365 20.1 20 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0846192296104677 0.160765238632437 1.007443735304 0.36 20.1 20 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.189240587807716 0.307316371388182 1.007443735304 0.36 20.1 20 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.189240587807716 0.307316371388182 1.007443735304 0.36 20.1 20 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.12139411443901 0.217287829995863 1.00457352523191 0.358974358974359 20.1 20 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.12139411443901 0.217287829995863 1.00457352523191 0.358974358974359 20.1 20 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.178731565057601 0.298344737178587 0.999448150103172 0.357142857142857 20.1 20 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.298342770061867 0.440853335200453 0.999448150103172 0.357142857142857 20.1 20 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.298342770061867 0.440853335200453 0.999448150103172 0.357142857142857 20.1 20 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.168976169137713 0.287322324233569 0.993000097521861 0.354838709677419 20.1 20 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.168976169137713 0.287322324233569 0.993000097521861 0.354838709677419 20.1 20 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.168976169137713 0.287322324233569 0.993000097521861 0.354838709677419 20.1 20 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.021562081589658 0.0504652008257949 0.99217943628424 0.354545454545455 20.1 20 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.276632363984312 0.419220291746193 0.987689936572546 0.352941176470588 20.1 20 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 7.9565521474568e-06 5.44335274318799e-05 0.983699270162152 0.351515151515152 20.1 20 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.257666958196791 0.40248087981782 0.979459187101108 0.35 20.1 20 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.136139072755882 0.236618459839932 0.976205169868214 0.348837209302326 20.1 20 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.24083098972621 0.381628617350108 0.973375589665698 0.347826086956522 20.1 20 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.24083098972621 0.381628617350108 0.973375589665698 0.347826086956522 20.1 20 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.24083098972621 0.381628617350108 0.973375589665698 0.347826086956522 20.1 20 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.225710391995208 0.360778548104629 0.968695899330767 0.346153846153846 20.1 20 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00659507467332345 0.0189975531581767 0.965964100404284 0.345177664974619 20.1 20 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00227888197969047 0.00770272935178036 0.965741271315379 0.345098039215686 20.1 20 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.054248792550831 0.111716399131451 0.963912215877281 0.344444444444444 20.1 20 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.100297136188136 0.186079302210844 0.963402479115844 0.344262295081967 20.1 20 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.199511477936196 0.320073092562803 0.961968844474303 0.34375 20.1 20 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0786613697545491 0.151879415414821 0.957366122730407 0.342105263157895 20.1 20 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00515270245628751 0.0155016820196556 0.943792606058211 0.337254901960784 20.1 20 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0561146618283293 0.115059313806502 0.941536201218689 0.336448598130841 20.1 20 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0446755218437633 0.0944851753337138 0.940464324851181 0.336065573770492 20.1 20 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.264523916824691 0.40518571974331 0.932818273429627 0.333333333333333 20.1 20 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0295217352850344 0.0663656071257567 0.932818273429627 0.333333333333333 20.1 20 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0295217352850344 0.0663656071257567 0.932818273429627 0.333333333333333 20.1 20 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0975526109022627 0.183136365849498 0.932818273429627 0.333333333333333 20.1 20 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.146781715696512 0.25317621992259 0.932818273429627 0.333333333333333 20.1 20 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.232236936615239 0.369243755087692 0.932818273429627 0.333333333333333 20.1 20 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.232236936615239 0.369243755087692 0.932818273429627 0.333333333333333 20.1 20 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.232236936615239 0.369243755087692 0.932818273429627 0.333333333333333 20.1 20 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.24756419681885 0.391426502303582 0.932818273429627 0.333333333333333 20.1 20 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.24756419681885 0.391426502303582 0.932818273429627 0.333333333333333 20.1 20 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.329322214877946 0.477215388769162 0.932818273429627 0.333333333333333 20.1 20 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.329322214877946 0.477215388769162 0.932818273429627 0.333333333333333 20.1 20 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.357989768040616 0.512720198255609 0.932818273429627 0.333333333333333 20.1 20 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.15817541028054 0.271185070878565 0.917526170586518 0.327868852459016 20.1 20 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.250375592887917 0.394993867715638 0.90760696874234 0.324324324324324 20.1 20 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.266832738176322 0.40828278110205 0.905382441858168 0.323529411764706 20.1 20 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.305162399240681 0.449995952455429 0.899503335092855 0.321428571428571 20.1 20 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.327791511505103 0.475966653950778 0.895505542492442 0.32 20.1 20 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.327791511505103 0.475966653950778 0.895505542492442 0.32 20.1 20 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.327791511505103 0.475966653950778 0.895505542492442 0.32 20.1 20 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.327791511505103 0.475966653950778 0.895505542492442 0.32 20.1 20 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0568855211647933 0.116304736519398 0.894854739045863 0.319767441860465 20.1 20 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.353473313680094 0.508891679879156 0.89041744281919 0.318181818181818 20.1 20 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.353473313680094 0.508891679879156 0.89041744281919 0.318181818181818 20.1 20 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.074687857793879 0.144801853405209 0.886467054874118 0.316770186335404 20.1 20 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.171222178060159 0.287322324233569 0.885586968445848 0.316455696202532 20.1 20 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.383073565837226 0.545113684186373 0.883722574828068 0.315789473684211 20.1 20 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.383073565837226 0.545113684186373 0.883722574828068 0.315789473684211 20.1 20 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.111678977713465 0.20564117528707 0.881403093004372 0.31496062992126 20.1 20 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0819560614487145 0.158026389487155 0.88099503601687 0.314814814814815 20.1 20 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.302943616027863 0.447187516190507 0.879514372090791 0.314285714285714 20.1 20 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.32383960769184 0.472155493591689 0.874517131340276 0.3125 20.1 20 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.417915972286596 0.577373231615366 0.874517131340276 0.3125 20.1 20 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.417915972286596 0.577373231615366 0.874517131340276 0.3125 20.1 20 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.417915972286596 0.577373231615366 0.874517131340276 0.3125 20.1 20 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.417915972286596 0.577373231615366 0.874517131340276 0.3125 20.1 20 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.417915972286596 0.577373231615366 0.874517131340276 0.3125 20.1 20 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.417915972286596 0.577373231615366 0.874517131340276 0.3125 20.1 20 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.417915972286596 0.577373231615366 0.874517131340276 0.3125 20.1 20 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.417915972286596 0.577373231615366 0.874517131340276 0.3125 20.1 20 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.111708101543855 0.20564117528707 0.86661826692817 0.309677419354839 20.1 20 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.263176981658947 0.403691828641304 0.864976944452927 0.309090909090909 20.1 20 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.373160897953946 0.532605775113806 0.861063021627348 0.307692307692308 20.1 20 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.121014866940231 0.217155303475345 0.858421724014994 0.306748466257669 20.1 20 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.295446235831731 0.437854715779097 0.856669842945576 0.306122448979592 20.1 20 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.257433119650377 0.40248087981782 0.851703640957486 0.304347826086957 20.1 20 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.313575176750991 0.461445167028605 0.851703640957486 0.304347826086957 20.1 20 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.313575176750991 0.461445167028605 0.851703640957486 0.304347826086957 20.1 20 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.363666855986015 0.520098428209145 0.848016612208752 0.303030303030303 20.1 20 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.164054396285377 0.280925879559677 0.847419417411422 0.302816901408451 20.1 20 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.185123217647354 0.307316371388182 0.839536446086664 0.3 20.1 20 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.436819254825984 0.598261597321824 0.839536446086664 0.3 20.1 20 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.436819254825984 0.598261597321824 0.839536446086664 0.3 20.1 20 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.436819254825984 0.598261597321824 0.839536446086664 0.3 20.1 20 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.389730837344916 0.550736808515765 0.839536446086664 0.3 20.1 20 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00064700948599953 0.00261560937095833 0.823155247138632 0.294146341463415 20.1 20 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.476784142412549 0.632895368146509 0.823074947143789 0.294117647058824 20.1 20 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.476784142412549 0.632895368146509 0.823074947143789 0.294117647058824 20.1 20 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.249659830609801 0.394301819043005 0.817067100814272 0.291970802919708 20.1 20 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.379590811236103 0.541240204798572 0.816215989250924 0.291666666666667 20.1 20 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.451877495199087 0.610351099638642 0.816215989250924 0.291666666666667 20.1 20 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.369152698626473 0.527413945929187 0.814095947720402 0.290909090909091 20.1 20 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.402705542948537 0.560714273596642 0.80844250363901 0.288888888888889 20.1 20 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.390414549086966 0.550736808515765 0.807246582775639 0.288461538461538 20.1 20 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.295698089855033 0.437854715779097 0.802498073465194 0.286764705882353 20.1 20 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.464398938947024 0.618184929954738 0.799558520082537 0.285714285714286 20.1 20 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.314019437922013 0.46162154975519 0.796640423293915 0.284671532846715 20.1 20 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.358147489153953 0.512720198255609 0.795350317345261 0.284210526315789 20.1 20 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.422905728382602 0.583700146933503 0.792015515176098 0.283018867924528 20.1 20 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.533500268387396 0.687032472321507 0.777348561191356 0.277777777777778 20.1 20 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.472816924409785 0.628802320967405 0.77404069497352 0.276595744680851 20.1 20 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.509091546093663 0.667786426641841 0.771987536631416 0.275862068965517 20.1 20 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.516930562119184 0.670548942475477 0.763214950987877 0.272727272727273 20.1 20 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.516930562119184 0.670548942475477 0.763214950987877 0.272727272727273 20.1 20 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.540669395380318 0.694379557424362 0.763214950987877 0.272727272727273 20.1 20 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.540669395380318 0.694379557424362 0.763214950987877 0.272727272727273 20.1 20 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.546912408313685 0.701131853180517 0.75343014392393 0.269230769230769 20.1 20 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.536079034994073 0.689729174318775 0.746254618743702 0.266666666666667 20.1 20 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.552495440184116 0.707651675411339 0.746254618743702 0.266666666666667 20.1 20 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.541458672713011 0.694766177881528 0.742447197219499 0.26530612244898 20.1 20 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.587224090726744 0.740020001460172 0.73643547902339 0.263157894736842 20.1 20 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.587224090726744 0.740020001460172 0.73643547902339 0.263157894736842 20.1 20 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.556069873061739 0.71158941489825 0.730520334613563 0.261044176706827 20.1 20 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.578340105196754 0.739423153364762 0.725525323778599 0.259259259259259 20.1 20 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.591715776562651 0.740020001460172 0.725525323778599 0.259259259259259 20.1 20 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.594204963198298 0.740020001460172 0.722181889106808 0.258064516129032 20.1 20 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.639614355752773 0.786664847222295 0.710958792181499 0.254054054054054 20.1 20 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.637359036026997 0.784569124797938 0.69961370507222 0.25 20.1 20 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.637359036026997 0.784569124797938 0.69961370507222 0.25 20.1 20 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.716862703152691 0.853636507603581 0.678413289767001 0.242424242424242 20.1 20 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.67781045415755 0.822271335265297 0.671629156869331 0.24 20.1 20 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.862616177841246 0.981166174046857 0.618889046794657 0.221153846153846 20.1 20 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.76337980933027 0.89924624890478 0.608359743541061 0.217391304347826 20.1 20 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.865329268045542 0.981166174046857 0.602199138543177 0.215189873417722 20.1 20 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.820877318685833 0.947370984987786 0.589148383218712 0.210526315789474 20.1 20 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.797119784815704 0.922385747247396 0.583011420893517 0.208333333333333 20.1 20 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.860652723289951 0.981166174046857 0.580811377795806 0.207547169811321 20.1 20 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.973797210104246 1 0.563103713838616 0.201219512195122 20.1 20 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.983514416750222 1 0.556681872853165 0.198924731182796 20.1 20 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.863035805960808 0.981166174046857 0.541636416830106 0.193548387096774 20.1 20 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.863035805960808 0.981166174046857 0.541636416830106 0.193548387096774 20.1 20 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.971932391321512 1 0.519300894486597 0.185567010309278 20.1 20 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.926966886061833 1 0.466409136714814 0.166666666666667 20.1 20 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.989831845617362 1 0.433563422861658 0.154929577464789 20.1 20 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999997946751 1 0.396688183288372 0.141752577319588 20.1 20 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.3571495656456 0.127623845507976 20.1 20 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999999834241329 1 0.348194839390782 0.124423963133641 20.1 20 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999999417058 1 0.329817889534047 0.117857142857143 20.1 20 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.994689954960562 1 0.325401723289405 0.116279069767442 20.1 20 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999721594867 1 0.318006229578282 0.113636363636364 20.1 20 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999972651500404 1 0.310939424476542 0.111111111111111 20.1 20 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.998246909949473 1 0.291505710446758 0.104166666666667 20.1 20 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.280857581421398 0.100361663652803 20.1 20 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999998214346661 1 0.21765759713358 0.0777777777777778 20.1 20 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0225681840345878 0.00806451612903226 20.1 20 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 4.63251950407023e-07 6.52680718246726e-06 4.05347832563682 1 21.1 21 1 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.000303060195235908 0.00147185890041194 4.05347832563682 1 21.1 21 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 7.84098805179671e-05 0.00044101683785402 3.54679353493222 0.875 21.1 21 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 7.84098805179671e-05 0.00044101683785402 3.54679353493222 0.875 21.1 21 1 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.000348433857624685 0.0016582654829429 3.47440999340299 0.857142857142857 21.1 21 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 1.72277430433395e-05 0.000120763932761932 3.31648226643013 0.818181818181818 21.1 21 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 7.16837478074846e-05 0.000411314407782462 3.24278266050946 0.8 21.1 21 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0002920023813382 0.00142301160494609 3.1527053643842 0.777777777777778 21.1 21 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 5.67052554169574e-05 0.0003334362746212 3.04010874422762 0.75 21.1 21 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 5.67052554169574e-05 0.0003334362746212 3.04010874422762 0.75 21.1 21 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00115850578894484 0.00509581413913606 3.04010874422762 0.75 21.1 21 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00115850578894484 0.00509581413913606 3.04010874422762 0.75 21.1 21 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00444432081269111 0.0158106712911486 2.89534166116916 0.714285714285714 21.1 21 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00444432081269111 0.0158106712911486 2.89534166116916 0.714285714285714 21.1 21 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00444432081269111 0.0158106712911486 2.89534166116916 0.714285714285714 21.1 21 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.58899292635718e-09 8.95988935825661e-08 2.83743482794578 0.7 21.1 21 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 2.92041231598207e-05 0.000191047954252754 2.78676634887532 0.6875 21.1 21 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 2.92041231598207e-05 0.000191047954252754 2.78676634887532 0.6875 21.1 21 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.24265047008978e-07 3.45339893077956e-06 2.75636526143304 0.68 21.1 21 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 6.78760797773031e-05 0.000391043164061143 2.62283891658853 0.647058823529412 21.1 21 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000349936041246958 0.0016598632889814 2.60580749505224 0.642857142857143 21.1 21 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.76047695828294e-06 1.95625419652719e-05 2.59422612840757 0.64 21.1 21 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 8.8019365455168e-06 6.73395467971527e-05 2.57948620722343 0.636363636363636 21.1 21 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 4.42968110191212e-05 0.000271699836552627 2.56009157408642 0.631578947368421 21.1 21 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 4.42968110191212e-05 0.000271699836552627 2.56009157408642 0.631578947368421 21.1 21 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.00992067918560157 0.0302293928931714 2.53342395352302 0.625 21.1 21 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00992067918560157 0.0302293928931714 2.53342395352302 0.625 21.1 21 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00992067918560157 0.0302293928931714 2.53342395352302 0.625 21.1 21 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00992067918560157 0.0302293928931714 2.53342395352302 0.625 21.1 21 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00115419066739205 0.00509581413913606 2.49444820039189 0.615384615384615 21.1 21 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00115419066739205 0.00509581413913606 2.49444820039189 0.615384615384615 21.1 21 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000143230093724007 0.000754875642108378 2.47712564344473 0.611111111111111 21.1 21 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 2.40816989635764e-06 2.39638165210974e-05 2.46104041199379 0.607142857142857 21.1 21 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.00601966272103047 0.0206907730725274 2.43208699538209 0.6 21.1 21 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.00601966272103047 0.0206907730725274 2.43208699538209 0.6 21.1 21 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.00601966272103047 0.0206907730725274 2.43208699538209 0.6 21.1 21 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 5.72770598285402e-05 0.000335412576691411 2.39523719242176 0.590909090909091 21.1 21 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000449052948476529 0.00208824295974543 2.38439901508049 0.588235294117647 21.1 21 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.68790317124827e-11 2.12997005597008e-09 2.36452902328815 0.583333333333333 21.1 21 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.68790317124827e-11 2.12997005597008e-09 2.36452902328815 0.583333333333333 21.1 21 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.68790317124827e-11 2.12997005597008e-09 2.36452902328815 0.583333333333333 21.1 21 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.68790317124827e-11 2.12997005597008e-09 2.36452902328815 0.583333333333333 21.1 21 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.68790317124827e-11 2.12997005597008e-09 2.36452902328815 0.583333333333333 21.1 21 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.68790317124827e-11 2.12997005597008e-09 2.36452902328815 0.583333333333333 21.1 21 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.68790317124827e-11 2.12997005597008e-09 2.36452902328815 0.583333333333333 21.1 21 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0036569394000729 0.0134215159512346 2.36452902328815 0.583333333333333 21.1 21 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0036569394000729 0.0134215159512346 2.36452902328815 0.583333333333333 21.1 21 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0036569394000729 0.0134215159512346 2.36452902328815 0.583333333333333 21.1 21 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0036569394000729 0.0134215159512346 2.36452902328815 0.583333333333333 21.1 21 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.26652221922701e-05 0.000152855977154504 2.3385451878674 0.576923076923077 21.1 21 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0001735559323583 0.000891588778865925 2.31627332893533 0.571428571428571 21.1 21 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0001735559323583 0.000891588778865925 2.31627332893533 0.571428571428571 21.1 21 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00222653016891884 0.00865670062943035 2.31627332893533 0.571428571428571 21.1 21 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00222653016891884 0.00865670062943035 2.31627332893533 0.571428571428571 21.1 21 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00222653016891884 0.00865670062943035 2.31627332893533 0.571428571428571 21.1 21 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00135891672919513 0.00585981365346869 2.28008155817071 0.5625 21.1 21 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 3.00326104658183e-07 4.31680855483429e-06 2.27390247535724 0.560975609756098 21.1 21 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 3.00326104658183e-07 4.31680855483429e-06 2.27390247535724 0.560975609756098 21.1 21 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 6.70140645123913e-05 0.00038797941124954 2.26994786235662 0.56 21.1 21 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.03905967195559e-08 2.27474140491202e-07 2.26059368160515 0.557692307692308 21.1 21 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.19557542196439e-06 2.21581831592576e-05 2.25193240313157 0.555555555555556 21.1 21 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0187071374124059 0.0504011077950475 2.25193240313157 0.555555555555556 21.1 21 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0187071374124059 0.0504011077950475 2.25193240313157 0.555555555555556 21.1 21 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0187071374124059 0.0504011077950475 2.25193240313157 0.555555555555556 21.1 21 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000509677569002073 0.00233206167424421 2.22941307910025 0.55 21.1 21 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000509677569002073 0.00233206167424421 2.22941307910025 0.55 21.1 21 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000509677569002073 0.00233206167424421 2.22941307910025 0.55 21.1 21 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000509677569002073 0.00233206167424421 2.22941307910025 0.55 21.1 21 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 6.52967426837705e-10 1.85834529678011e-08 2.21674595933264 0.546875 21.1 21 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0110386861467394 0.0325218434509528 2.21098817762009 0.545454545454545 21.1 21 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0110386861467394 0.0325218434509528 2.21098817762009 0.545454545454545 21.1 21 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0110386861467394 0.0325218434509528 2.21098817762009 0.545454545454545 21.1 21 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0110386861467394 0.0325218434509528 2.21098817762009 0.545454545454545 21.1 21 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0110386861467394 0.0325218434509528 2.21098817762009 0.545454545454545 21.1 21 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0110386861467394 0.0325218434509528 2.21098817762009 0.545454545454545 21.1 21 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0110386861467394 0.0325218434509528 2.21098817762009 0.545454545454545 21.1 21 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.61685985701572e-09 1.07756342775414e-07 2.19849671898946 0.542372881355932 21.1 21 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.61685985701572e-09 1.07756342775414e-07 2.19849671898946 0.542372881355932 21.1 21 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000192669823803954 0.000972231061251869 2.19563409305328 0.541666666666667 21.1 21 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000192669823803954 0.000972231061251869 2.19563409305328 0.541666666666667 21.1 21 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000192669823803954 0.000972231061251869 2.19563409305328 0.541666666666667 21.1 21 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 3.88856678384216e-06 3.5931367100048e-05 2.19106936520909 0.540540540540541 21.1 21 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00657681292153388 0.0217141642397743 2.18264217534291 0.538461538461538 21.1 21 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00657681292153388 0.0217141642397743 2.18264217534291 0.538461538461538 21.1 21 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.51065059659524e-06 1.79137983246252e-05 2.17503715034171 0.536585365853659 21.1 21 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.51065059659524e-06 1.79137983246252e-05 2.17503715034171 0.536585365853659 21.1 21 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 7.33008395633091e-05 0.000417228378794355 2.17150624587687 0.535714285714286 21.1 21 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 4.53033881998795e-05 0.000275498809437729 2.16185510700631 0.533333333333333 21.1 21 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00394714332958155 0.0142197087544166 2.16185510700631 0.533333333333333 21.1 21 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00394714332958155 0.0142197087544166 2.16185510700631 0.533333333333333 21.1 21 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00394714332958155 0.0142197087544166 2.16185510700631 0.533333333333333 21.1 21 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.29062501218716e-07 3.46761637483226e-06 2.15082523401138 0.530612244897959 21.1 21 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.7364127001315e-05 0.000121123297661134 2.14595911357244 0.529411764705882 21.1 21 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00238251348250355 0.0090893208729291 2.14595911357244 0.529411764705882 21.1 21 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.07662493495582e-05 7.86111614747977e-05 2.13933578297499 0.527777777777778 21.1 21 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 7.5310930161499e-11 2.74018472619044e-09 2.12807612095933 0.525 21.1 21 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.14956841205948e-06 3.73723787997509e-05 2.12807612095933 0.525 21.1 21 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 5.99501310124979e-16 5.33181477692403e-14 2.12480718682575 0.524193548387097 21.1 21 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 5.99501310124979e-16 5.33181477692403e-14 2.12480718682575 0.524193548387097 21.1 21 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 5.99501310124979e-16 5.33181477692403e-14 2.12480718682575 0.524193548387097 21.1 21 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00087941136931022 0.00393522760543536 2.12325055152405 0.523809523809524 21.1 21 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 9.98297664310829e-07 1.23528484896896e-05 2.114858256854 0.521739130434783 21.1 21 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000328796896369815 0.00158066886329138 2.10780872933115 0.52 21.1 21 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000328796896369815 0.00158066886329138 2.10780872933115 0.52 21.1 21 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000201784934330088 0.00101105620264688 2.10180357625613 0.518518518518518 21.1 21 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000201784934330088 0.00101105620264688 2.10180357625613 0.518518518518518 21.1 21 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.82590358330622e-13 2.7469043196179e-11 2.06427136953727 0.509259259259259 21.1 21 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 4.75129693641029e-05 0.00028770619321327 2.02673916281841 0.5 21.1 21 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000330269029096866 0.00158240009563919 2.02673916281841 0.5 21.1 21 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000538839412187096 0.00244973956403271 2.02673916281841 0.5 21.1 21 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00237980359699663 0.0090893208729291 2.02673916281841 0.5 21.1 21 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00237980359699663 0.0090893208729291 2.02673916281841 0.5 21.1 21 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00237980359699663 0.0090893208729291 2.02673916281841 0.5 21.1 21 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00237980359699663 0.0090893208729291 2.02673916281841 0.5 21.1 21 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00393369544808992 0.0142197087544166 2.02673916281841 0.5 21.1 21 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00653536992996799 0.0216779286954416 2.02673916281841 0.5 21.1 21 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00653536992996799 0.0216779286954416 2.02673916281841 0.5 21.1 21 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00653536992996799 0.0216779286954416 2.02673916281841 0.5 21.1 21 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00653536992996799 0.0216779286954416 2.02673916281841 0.5 21.1 21 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0109270956741489 0.0325218434509528 2.02673916281841 0.5 21.1 21 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0109270956741489 0.0325218434509528 2.02673916281841 0.5 21.1 21 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0109270956741489 0.0325218434509528 2.02673916281841 0.5 21.1 21 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0109270956741489 0.0325218434509528 2.02673916281841 0.5 21.1 21 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0184204328934059 0.050023427494879 2.02673916281841 0.5 21.1 21 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0184204328934059 0.050023427494879 2.02673916281841 0.5 21.1 21 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0184204328934059 0.050023427494879 2.02673916281841 0.5 21.1 21 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0184204328934059 0.050023427494879 2.02673916281841 0.5 21.1 21 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0184204328934059 0.050023427494879 2.02673916281841 0.5 21.1 21 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0184204328934059 0.050023427494879 2.02673916281841 0.5 21.1 21 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0184204328934059 0.050023427494879 2.02673916281841 0.5 21.1 21 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0313946121037814 0.0774255338365353 2.02673916281841 0.5 21.1 21 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0313946121037814 0.0774255338365353 2.02673916281841 0.5 21.1 21 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0313946121037814 0.0774255338365353 2.02673916281841 0.5 21.1 21 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0313946121037814 0.0774255338365353 2.02673916281841 0.5 21.1 21 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0313946121037814 0.0774255338365353 2.02673916281841 0.5 21.1 21 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0313946121037814 0.0774255338365353 2.02673916281841 0.5 21.1 21 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0313946121037814 0.0774255338365353 2.02673916281841 0.5 21.1 21 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0313946121037814 0.0774255338365353 2.02673916281841 0.5 21.1 21 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 9.26614947107272e-09 2.06027042145882e-07 1.99971597398083 0.493333333333333 21.1 21 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 6.07949727876923e-08 1.10911854201136e-06 1.99648932456739 0.492537313432836 21.1 21 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 6.07949727876923e-08 1.10911854201136e-06 1.99648932456739 0.492537313432836 21.1 21 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.65934030520522e-06 1.9079868799959e-05 1.9884988012558 0.490566037735849 21.1 21 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.66668964546926e-06 2.59910915445395e-05 1.98699917923374 0.490196078431373 21.1 21 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.66668964546926e-06 2.59910915445395e-05 1.98699917923374 0.490196078431373 21.1 21 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 6.90089439246262e-06 5.51683860700804e-05 1.98361705297121 0.48936170212766 21.1 21 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.38519896920972e-10 1.02492300706073e-08 1.96273687346625 0.484210526315789 21.1 21 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000522706079506784 0.00238400881775049 1.95685160547985 0.482758620689655 21.1 21 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.92911308339118e-12 3.76104263922188e-10 1.95562550798268 0.482456140350877 21.1 21 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.61923178894722e-06 1.90427011212554e-05 1.95435562128918 0.482142857142857 21.1 21 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000851818570197178 0.00384805658854154 1.95167474938069 0.481481481481481 21.1 21 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00139135938610121 0.00592785750425754 1.94566959630568 0.48 21.1 21 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00139135938610121 0.00592785750425754 1.94566959630568 0.48 21.1 21 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00139135938610121 0.00592785750425754 1.94566959630568 0.48 21.1 21 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.07724360418732e-05 7.86111614747977e-05 1.94229169770098 0.479166666666667 21.1 21 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 1.07724360418732e-05 7.86111614747977e-05 1.94229169770098 0.479166666666667 21.1 21 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00227873699838503 0.00881152920842909 1.93862006878283 0.478260869565217 21.1 21 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.37661953611145e-07 3.5228433332152e-06 1.93598964806535 0.477611940298507 21.1 21 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 4.49313712507908e-05 0.000274409190085302 1.93022777411277 0.476190476190476 21.1 21 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00374379653125699 0.0136251213912499 1.93022777411277 0.476190476190476 21.1 21 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 7.24447718333466e-05 0.000414011688027519 1.92540220467749 0.475 21.1 21 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00617375482667143 0.0211183969191189 1.92006868056481 0.473684210526316 21.1 21 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00617375482667143 0.0211183969191189 1.92006868056481 0.473684210526316 21.1 21 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 4.00168236277117e-06 3.6738025820796e-05 1.91618975393741 0.472727272727273 21.1 21 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.42678975240198e-07 2.30718388371366e-06 1.91414254266183 0.472222222222222 21.1 21 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 6.33403597198035e-15 4.50666659406402e-13 1.91201807813058 0.471698113207547 21.1 21 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.00604790009731e-14 6.50730073562941e-13 1.91055666303901 0.471337579617834 21.1 21 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0102267978832697 0.0308975231165452 1.90751921206439 0.470588235294118 21.1 21 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.65027799786354e-05 0.000177058478448818 1.89737283327681 0.468085106382979 21.1 21 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.35727807860258e-07 2.22000770787525e-06 1.89162321863052 0.466666666666667 21.1 21 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.35727807860258e-07 2.22000770787525e-06 1.89162321863052 0.466666666666667 21.1 21 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.35727807860258e-07 2.22000770787525e-06 1.89162321863052 0.466666666666667 21.1 21 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.35727807860258e-07 2.22000770787525e-06 1.89162321863052 0.466666666666667 21.1 21 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.35727807860258e-07 2.22000770787525e-06 1.89162321863052 0.466666666666667 21.1 21 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 4.25719239228466e-05 0.000265701086588644 1.89162321863052 0.466666666666667 21.1 21 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.25719239228466e-05 0.000265701086588644 1.89162321863052 0.466666666666667 21.1 21 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000802563032349193 0.00363709297781179 1.89162321863052 0.466666666666667 21.1 21 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0170345539756453 0.0469770742390373 1.89162321863052 0.466666666666667 21.1 21 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0170345539756453 0.0469770742390373 1.89162321863052 0.466666666666667 21.1 21 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0170345539756453 0.0469770742390373 1.89162321863052 0.466666666666667 21.1 21 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0170345539756453 0.0469770742390373 1.89162321863052 0.466666666666667 21.1 21 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.25535139168014e-08 2.70661368236491e-07 1.88855240171716 0.465909090909091 21.1 21 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.16366342875281e-07 3.38339896606072e-06 1.88792141194044 0.465753424657534 21.1 21 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 3.79309752903677e-06 3.52782861687537e-05 1.88696404814128 0.46551724137931 21.1 21 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.99748129390588e-08 4.08496045380659e-07 1.88533875611015 0.465116279069767 21.1 21 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00130382817248412 0.00563935407126109 1.88197207975995 0.464285714285714 21.1 21 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 5.50007811431255e-07 7.52558765064112e-06 1.87987400609244 0.463768115942029 21.1 21 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.69493552500049e-09 1.07756342775414e-07 1.87740048766337 0.463157894736842 21.1 21 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.69493552500049e-09 1.07756342775414e-07 1.87740048766337 0.463157894736842 21.1 21 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.16428477013428e-19 7.40722153487635e-17 1.8722343835901 0.461883408071749 21.1 21 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0021220907923133 0.00843412624405251 1.87083615029392 0.461538461538462 21.1 21 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0021220907923133 0.00843412624405251 1.87083615029392 0.461538461538462 21.1 21 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0285721071550106 0.0717074223661024 1.87083615029392 0.461538461538462 21.1 21 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0285721071550106 0.0717074223661024 1.87083615029392 0.461538461538462 21.1 21 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0285721071550106 0.0717074223661024 1.87083615029392 0.461538461538462 21.1 21 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 2.23104171109477e-06 2.23575517949849e-05 1.86588684830901 0.46031746031746 21.1 21 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.99220293851301e-08 5.94521222380025e-07 1.86366819569509 0.459770114942529 21.1 21 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000285315910902194 0.00139520460898221 1.86240896042773 0.459459459459459 21.1 21 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000285315910902194 0.00139520460898221 1.86240896042773 0.459459459459459 21.1 21 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.55898124582282e-06 3.37628687520392e-05 1.86061300193166 0.459016393442623 21.1 21 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.55898124582282e-06 3.37628687520392e-05 1.86061300193166 0.459016393442623 21.1 21 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00346115881999302 0.0129106829386415 1.85784423258354 0.458333333333333 21.1 21 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00346115881999302 0.0129106829386415 1.85784423258354 0.458333333333333 21.1 21 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.000102204451821023 0.00056153256734099 1.84249014801674 0.454545454545455 21.1 21 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0056588501746158 0.0195925639865652 1.84249014801674 0.454545454545455 21.1 21 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0483578837346496 0.110632264556923 1.84249014801674 0.454545454545455 21.1 21 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0483578837346496 0.110632264556923 1.84249014801674 0.454545454545455 21.1 21 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0483578837346496 0.110632264556923 1.84249014801674 0.454545454545455 21.1 21 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0483578837346496 0.110632264556923 1.84249014801674 0.454545454545455 21.1 21 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.44580802924258e-05 0.000102357454010557 1.84249014801674 0.454545454545455 21.1 21 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.44580802924258e-05 0.000102357454010557 1.84249014801674 0.454545454545455 21.1 21 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 3.31017136385341e-06 3.1826850342996e-05 1.83673236630419 0.453125 21.1 21 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.32145269814955e-17 6.8840247176971e-15 1.83371638540713 0.452380952380952 21.1 21 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 7.63383634030886e-07 9.61322930288452e-06 1.83239431158925 0.452054794520548 21.1 21 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00927789674185994 0.0285150044571635 1.82406524653657 0.45 21.1 21 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00927789674185994 0.0285150044571635 1.82406524653657 0.45 21.1 21 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 8.38273425732655e-06 6.48295154792157e-05 1.82406524653657 0.45 21.1 21 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.92463518983701e-06 1.95625419652719e-05 1.82112794340205 0.449275362318841 21.1 21 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 5.88020772586728e-05 0.00034293178663562 1.81992904416347 0.448979591836735 21.1 21 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0019384898730282 0.00811315026270333 1.81707649080271 0.448275862068966 21.1 21 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0019384898730282 0.00811315026270333 1.81707649080271 0.448275862068966 21.1 21 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 5.33016136994344e-14 3.1603415122623e-12 1.80917959166841 0.446327683615819 21.1 21 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 9.50813786825536e-08 1.67038026994165e-06 1.80154592250526 0.444444444444444 21.1 21 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.76905546355692e-06 1.95625419652719e-05 1.80154592250526 0.444444444444444 21.1 21 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.6970715049707e-06 6.08496263976295e-05 1.80154592250526 0.444444444444444 21.1 21 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.37716991324446e-05 0.000214540749399413 1.80154592250526 0.444444444444444 21.1 21 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 3.37716991324446e-05 0.000214540749399413 1.80154592250526 0.444444444444444 21.1 21 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 3.37716991324446e-05 0.000214540749399413 1.80154592250526 0.444444444444444 21.1 21 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00313830857000621 0.0118143203574573 1.80154592250526 0.444444444444444 21.1 21 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0152612798314135 0.0430035667328742 1.80154592250526 0.444444444444444 21.1 21 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0152612798314135 0.0430035667328742 1.80154592250526 0.444444444444444 21.1 21 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0152612798314135 0.0430035667328742 1.80154592250526 0.444444444444444 21.1 21 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0152612798314135 0.0430035667328742 1.80154592250526 0.444444444444444 21.1 21 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0152612798314135 0.0430035667328742 1.80154592250526 0.444444444444444 21.1 21 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0152612798314135 0.0430035667328742 1.80154592250526 0.444444444444444 21.1 21 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 6.47011022784179e-07 8.29456473353052e-06 1.79584482781378 0.443037974683544 21.1 21 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 6.47011022784179e-07 8.29456473353052e-06 1.79584482781378 0.443037974683544 21.1 21 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 6.47011022784179e-07 8.29456473353052e-06 1.79584482781378 0.443037974683544 21.1 21 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 1.22133616488148e-05 8.86714980931808e-05 1.79416253757695 0.442622950819672 21.1 21 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.55987992923443e-19 5.20387019900085e-17 1.79288464403167 0.442307692307692 21.1 21 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.62508817664719e-10 8.30111216748657e-09 1.79107181830464 0.441860465116279 21.1 21 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.3716611354926e-07 3.5228433332152e-06 1.79107181830464 0.441860465116279 21.1 21 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.93754376208233e-05 0.000131961555918963 1.78627858417894 0.440677966101695 21.1 21 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.20371120702795e-08 6.24504253095996e-07 1.7835304632802 0.44 21.1 21 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 8.546908849528e-05 0.000476055354179182 1.7835304632802 0.44 21.1 21 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00508742980376517 0.0179193381454402 1.7835304632802 0.44 21.1 21 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00508742980376517 0.0179193381454402 1.7835304632802 0.44 21.1 21 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000382312822939498 0.00178957614158851 1.77957585027958 0.439024390243902 21.1 21 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000382312822939498 0.00178957614158851 1.77957585027958 0.439024390243902 21.1 21 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 5.04583349062353e-08 9.44765928573326e-07 1.77856702043248 0.438775510204082 21.1 21 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000135938530647799 0.000721793019073948 1.77339676746611 0.4375 21.1 21 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0252005860111721 0.0654274484966194 1.77339676746611 0.4375 21.1 21 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0252005860111721 0.0654274484966194 1.77339676746611 0.4375 21.1 21 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0252005860111721 0.0654274484966194 1.77339676746611 0.4375 21.1 21 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0252005860111721 0.0654274484966194 1.77339676746611 0.4375 21.1 21 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0252005860111721 0.0654274484966194 1.77339676746611 0.4375 21.1 21 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 4.87241782343942e-05 0.000291321452216567 1.76879054209607 0.436363636363636 21.1 21 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.87241782343942e-05 0.000291321452216567 1.76879054209607 0.436363636363636 21.1 21 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 4.87241782343942e-05 0.000291321452216567 1.76879054209607 0.436363636363636 21.1 21 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.4695716686528e-06 1.77220380041774e-05 1.76690080861092 0.435897435897436 21.1 21 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.52465517291583e-12 7.74851539664011e-11 1.76445527115956 0.435294117647059 21.1 21 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000216166762382378 0.0010755430170284 1.76238188071166 0.434782608695652 21.1 21 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.000216166762382378 0.0010755430170284 1.76238188071166 0.434782608695652 21.1 21 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00825893723325487 0.0257729554450037 1.76238188071166 0.434782608695652 21.1 21 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 7.72297473046035e-05 0.000437840360216936 1.75905663188013 0.433962264150943 21.1 21 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.18605389363222e-15 4.50666659406402e-13 1.75650727444262 0.433333333333333 21.1 21 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.77816225458502e-05 0.000184734807863293 1.75650727444262 0.433333333333333 21.1 21 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.00471857159157e-05 7.48541637369005e-05 1.75449061855922 0.432835820895522 21.1 21 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.00471857159157e-05 7.48541637369005e-05 1.75449061855922 0.432835820895522 21.1 21 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 3.6489700440064e-06 3.41610813988231e-05 1.75285549216728 0.432432432432432 21.1 21 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 3.6489700440064e-06 3.41610813988231e-05 1.75285549216728 0.432432432432432 21.1 21 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.32979111931423e-06 1.61734424169585e-05 1.75150298021344 0.432098765432099 21.1 21 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.32979111931423e-06 1.61734424169585e-05 1.75150298021344 0.432098765432099 21.1 21 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.39427079393265e-12 1.66553356543661e-10 1.75091075604431 0.431952662721893 21.1 21 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.83629038713958e-10 8.77400265412962e-09 1.74970287437561 0.431654676258993 21.1 21 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 4.3904483786294e-05 0.000271635132295201 1.74718893346415 0.431034482758621 21.1 21 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.2021803891944e-09 3.28981287273776e-08 1.74611374027432 0.430769230769231 21.1 21 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.29719189360616e-11 5.95452924065021e-10 1.74075756315692 0.429447852760736 21.1 21 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0134284718998121 0.0387600720353603 1.7372049967015 0.428571428571429 21.1 21 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0134284718998121 0.0387600720353603 1.7372049967015 0.428571428571429 21.1 21 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0134284718998121 0.0387600720353603 1.7372049967015 0.428571428571429 21.1 21 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0418058657656568 0.0975241753844747 1.7372049967015 0.428571428571429 21.1 21 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0418058657656568 0.0975241753844747 1.7372049967015 0.428571428571429 21.1 21 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0418058657656568 0.0975241753844747 1.7372049967015 0.428571428571429 21.1 21 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0418058657656568 0.0975241753844747 1.7372049967015 0.428571428571429 21.1 21 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0418058657656568 0.0975241753844747 1.7372049967015 0.428571428571429 21.1 21 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.00903553534242e-10 1.16425664628414e-08 1.7372049967015 0.428571428571429 21.1 21 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 9.04163612022746e-06 6.88034663052603e-05 1.7372049967015 0.428571428571429 21.1 21 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00155717390497649 0.00659481686542126 1.7372049967015 0.428571428571429 21.1 21 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 8.55424335733985e-11 2.96894836524259e-09 1.73339533662101 0.427631578947368 21.1 21 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 6.86814540248989e-07 8.72622402477063e-06 1.73069861094606 0.426966292134831 21.1 21 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.88009631313175e-06 1.95625419652719e-05 1.73014318777182 0.426829268292683 21.1 21 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.44583542115436e-12 7.6200881640839e-11 1.72771207322225 0.426229508196721 21.1 21 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.70255720643835e-11 2.74018472619044e-09 1.72599722252923 0.425806451612903 21.1 21 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.13655575982447e-09 1.01488255969487e-07 1.72352621719991 0.425196850393701 21.1 21 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000867639069122044 0.00389479619987592 1.72272828839565 0.425 21.1 21 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000867639069122044 0.00389479619987592 1.72272828839565 0.425 21.1 21 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00248628934839718 0.00943463931405117 1.71965747148229 0.424242424242424 21.1 21 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.25696486691848e-07 3.45339893077956e-06 1.71965747148229 0.424242424242424 21.1 21 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.75703164004831e-08 9.02567469838499e-07 1.71633766941379 0.423423423423423 21.1 21 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00726201174549652 0.0230666132005392 1.71493313776943 0.423076923076923 21.1 21 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00726201174549652 0.0230666132005392 1.71493313776943 0.423076923076923 21.1 21 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00726201174549652 0.0230666132005392 1.71493313776943 0.423076923076923 21.1 21 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.27061643448034e-05 9.13175346598751e-05 1.71273732069162 0.422535211267606 21.1 21 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 7.42116052057052e-08 1.32003892759648e-06 1.71064222916783 0.422018348623853 21.1 21 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.5097141928215e-05 0.000221969924283777 1.71006116862804 0.421875 21.1 21 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.77207374278932e-14 1.09637431999531e-12 1.7086410879366 0.42152466367713 21.1 21 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.22737844958207e-09 3.29539534670808e-08 1.7082515800898 0.421428571428571 21.1 21 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 7.23070857772932e-06 5.74821134419487e-05 1.70672771605761 0.421052631578947 21.1 21 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0218703889257715 0.0577394497984653 1.70672771605761 0.421052631578947 21.1 21 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0218703889257715 0.0577394497984653 1.70672771605761 0.421052631578947 21.1 21 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0218703889257715 0.0577394497984653 1.70672771605761 0.421052631578947 21.1 21 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00027223078193384 0.00134043045914136 1.70246089676747 0.42 21.1 21 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 4.11822930981666e-06 3.73263713877014e-05 1.70146003792163 0.419753086419753 21.1 21 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 4.11822930981666e-06 3.73263713877014e-05 1.70146003792163 0.419753086419753 21.1 21 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 6.62930674177108e-08 1.19411436627092e-06 1.70101322593688 0.419642857142857 21.1 21 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 5.50731439789107e-05 0.000326537849508292 1.6998457494606 0.419354838709677 21.1 21 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00396870559287543 0.0142253603492739 1.6998457494606 0.419354838709677 21.1 21 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00396870559287543 0.0142253603492739 1.6998457494606 0.419354838709677 21.1 21 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 5.12055422282473e-17 6.8840247176971e-15 1.69888429824485 0.419117647058824 21.1 21 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.34168631128721e-10 4.4400456301435e-09 1.69739404886042 0.41875 21.1 21 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.08246740665156e-10 6.73488890832995e-09 1.69322512336728 0.417721518987342 21.1 21 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 6.43169250011641e-06 5.22988481580894e-05 1.69322512336728 0.417721518987342 21.1 21 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0116859218141562 0.0340062714551006 1.68894930234868 0.416666666666667 21.1 21 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0116859218141562 0.0340062714551006 1.68894930234868 0.416666666666667 21.1 21 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0116859218141562 0.0340062714551006 1.68894930234868 0.416666666666667 21.1 21 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0697417771926808 0.150485994948802 1.68894930234868 0.416666666666667 21.1 21 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0697417771926808 0.150485994948802 1.68894930234868 0.416666666666667 21.1 21 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0697417771926808 0.150485994948802 1.68894930234868 0.416666666666667 21.1 21 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0697417771926808 0.150485994948802 1.68894930234868 0.416666666666667 21.1 21 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.76780325355546e-05 0.000121525798541518 1.68894930234868 0.416666666666667 21.1 21 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.76780325355546e-05 0.000121525798541518 1.68894930234868 0.416666666666667 21.1 21 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.76780325355546e-05 0.000121525798541518 1.68894930234868 0.416666666666667 21.1 21 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.72313729670659e-51 3.87502437321348e-48 1.68742084144157 0.416289592760181 21.1 21 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 5.70357351580186e-06 4.66447420286554e-05 1.68071052526405 0.414634146341463 21.1 21 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00121141182683468 0.00525560679751751 1.68071052526405 0.414634146341463 21.1 21 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00121141182683468 0.00525560679751751 1.68071052526405 0.414634146341463 21.1 21 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00121141182683468 0.00525560679751751 1.68071052526405 0.414634146341463 21.1 21 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00121141182683468 0.00525560679751751 1.68071052526405 0.414634146341463 21.1 21 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.00811862342669e-08 5.94521222380025e-07 1.68071052526405 0.414634146341463 21.1 21 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 9.77363271966425e-16 7.72659964449012e-14 1.67730137612558 0.413793103448276 21.1 21 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.000135219975137307 0.000720666758877857 1.67730137612558 0.413793103448276 21.1 21 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.000135219975137307 0.000720666758877857 1.67730137612558 0.413793103448276 21.1 21 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000135219975137307 0.000720666758877857 1.67730137612558 0.413793103448276 21.1 21 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000135219975137307 0.000720666758877857 1.67730137612558 0.413793103448276 21.1 21 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000135219975137307 0.000720666758877857 1.67730137612558 0.413793103448276 21.1 21 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00633229521764395 0.0215565821708846 1.67730137612558 0.413793103448276 21.1 21 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.95138774193387e-10 1.16425664628414e-08 1.67205980932519 0.4125 21.1 21 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.52787778400793e-08 3.19730895094602e-07 1.67089946247625 0.412213740458015 21.1 21 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.52787778400793e-08 3.19730895094602e-07 1.67089946247625 0.412213740458015 21.1 21 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 4.30520034637619e-05 0.000267524021523726 1.66907931055634 0.411764705882353 21.1 21 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00346583336792767 0.0129106829386415 1.66907931055634 0.411764705882353 21.1 21 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0356822377007038 0.0854811856028645 1.66907931055634 0.411764705882353 21.1 21 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0356822377007038 0.0854811856028645 1.66907931055634 0.411764705882353 21.1 21 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0356822377007038 0.0854811856028645 1.66907931055634 0.411764705882353 21.1 21 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0356822377007038 0.0854811856028645 1.66907931055634 0.411764705882353 21.1 21 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0356822377007038 0.0854811856028645 1.66907931055634 0.411764705882353 21.1 21 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0356822377007038 0.0854811856028645 1.66907931055634 0.411764705882353 21.1 21 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0356822377007038 0.0854811856028645 1.66907931055634 0.411764705882353 21.1 21 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000377136888261196 0.00177703904634332 1.66907931055634 0.411764705882353 21.1 21 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.000377136888261196 0.00177703904634332 1.66907931055634 0.411764705882353 21.1 21 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 5.04412595078313e-06 4.19753872980374e-05 1.66907931055634 0.411764705882353 21.1 21 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.42663287072117e-07 4.87609857503623e-06 1.66685090026187 0.411214953271028 21.1 21 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.43595170927963e-05 0.00016350751331627 1.66581301053568 0.410958904109589 21.1 21 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 9.30547342561859e-07 1.16155163900485e-05 1.6619261135111 0.41 21.1 21 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.45002868535239e-06 3.98263573538141e-05 1.65824113321506 0.409090909090909 21.1 21 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0188074407864865 0.0504011077950475 1.65824113321506 0.409090909090909 21.1 21 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0188074407864865 0.0504011077950475 1.65824113321506 0.409090909090909 21.1 21 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0188074407864865 0.0504011077950475 1.65824113321506 0.409090909090909 21.1 21 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0188074407864865 0.0504011077950475 1.65824113321506 0.409090909090909 21.1 21 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 6.70716339897307e-05 0.00038797941124954 1.65824113321506 0.409090909090909 21.1 21 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.5307694891933e-06 2.50089234939033e-05 1.6562599610129 0.408602150537634 21.1 21 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.04254741286832e-23 3.70886242127904e-21 1.65564607666856 0.408450704225352 21.1 21 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 7.2920075460502e-16 6.10383925766437e-14 1.65358502092766 0.407942238267148 21.1 21 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0100970576786461 0.0305704533547094 1.65141709562982 0.407407407407407 21.1 21 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0100970576786461 0.0305704533547094 1.65141709562982 0.407407407407407 21.1 21 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 6.8948775887576e-06 5.51683860700804e-05 1.64967141159638 0.406976744186047 21.1 21 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000185468725761797 0.000945956977630957 1.6488725392421 0.406779661016949 21.1 21 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.21447723200189e-20 2.88033516856448e-18 1.64740295587379 0.406417112299465 21.1 21 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00548924967095782 0.0190982940874645 1.64672556978996 0.40625 21.1 21 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00166378280758757 0.00702540930325553 1.64069360799586 0.404761904761905 21.1 21 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000924194617748708 0.00412266125723013 1.63864017419361 0.404255319148936 21.1 21 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 6.3502335777297e-07 8.29456473353052e-06 1.63626648007358 0.403669724770642 21.1 21 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.00016215011955039 0.000848307426912521 1.63446706678904 0.403225806451613 21.1 21 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.25333429264065e-16 5.33181477692403e-14 1.63245884786739 0.402730375426621 21.1 21 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.35134432559717e-09 3.56104254689773e-08 1.63127786275628 0.402439024390244 21.1 21 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 9.35166925101901e-06 7.04096579058204e-05 1.63070967123321 0.402298850574713 21.1 21 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 9.35166925101901e-06 7.04096579058204e-05 1.63070967123321 0.402298850574713 21.1 21 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 5.30955976194411e-06 4.39273461700376e-05 1.63020323965829 0.402173913043478 21.1 21 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.17914338889752e-27 2.26196052120058e-24 1.62601506978968 0.401140684410646 21.1 21 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.27896394356682e-10 4.33325164689427e-09 1.62572660119124 0.401069518716578 21.1 21 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00260698446591684 0.00986632684840337 1.62139133025473 0.4 21.1 21 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0302653837150458 0.0756900545281373 1.62139133025473 0.4 21.1 21 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0302653837150458 0.0756900545281373 1.62139133025473 0.4 21.1 21 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000141415302595059 0.000748081693653415 1.62139133025473 0.4 21.1 21 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.000448736687803613 0.00208824295974543 1.62139133025473 0.4 21.1 21 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00144340573067404 0.00613124284999747 1.62139133025473 0.4 21.1 21 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00473827300989513 0.0167725435151263 1.62139133025473 0.4 21.1 21 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0583200736256645 0.12728445516767 1.62139133025473 0.4 21.1 21 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0583200736256645 0.12728445516767 1.62139133025473 0.4 21.1 21 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0583200736256645 0.12728445516767 1.62139133025473 0.4 21.1 21 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0583200736256645 0.12728445516767 1.62139133025473 0.4 21.1 21 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0583200736256645 0.12728445516767 1.62139133025473 0.4 21.1 21 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 4.52659729418522e-17 6.8840247176971e-15 1.61641773721714 0.398773006134969 21.1 21 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00225011934011839 0.00872457716890591 1.60253794269363 0.395348837209302 21.1 21 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.71316816925568e-07 7.66965877816116e-06 1.60095362441118 0.394957983193277 21.1 21 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.42751336952757e-06 4.46436504325881e-05 1.59682479494784 0.393939393939394 21.1 21 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00744117388062222 0.0234265275047023 1.59682479494784 0.393939393939394 21.1 21 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00744117388062222 0.0234265275047023 1.59682479494784 0.393939393939394 21.1 21 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00744117388062222 0.0234265275047023 1.59682479494784 0.393939393939394 21.1 21 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.84298818874588e-07 4.17069298204679e-06 1.59585760851843 0.393700787401575 21.1 21 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000337553027923029 0.00161187234474655 1.59481114451285 0.39344262295082 21.1 21 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.96708347785373e-05 0.000191047954252754 1.59243791364304 0.392857142857143 21.1 21 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.96708347785373e-05 0.000191047954252754 1.59243791364304 0.392857142857143 21.1 21 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0137095151442627 0.0394113940409815 1.59243791364304 0.392857142857143 21.1 21 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0137095151442627 0.0394113940409815 1.59243791364304 0.392857142857143 21.1 21 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.68755241391298e-06 2.6016238673457e-05 1.59108495024997 0.392523364485981 21.1 21 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0255886216421354 0.0658455851659288 1.5861436926405 0.391304347826087 21.1 21 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0255886216421354 0.0658455851659288 1.5861436926405 0.391304347826087 21.1 21 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000164352548254083 0.00085355356264803 1.5861436926405 0.391304347826087 21.1 21 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.000164352548254083 0.00085355356264803 1.5861436926405 0.391304347826087 21.1 21 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.00946754579383e-08 4.08496045380659e-07 1.58501396066568 0.391025641025641 21.1 21 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00636244870820207 0.0215565821708846 1.5763526821921 0.388888888888889 21.1 21 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00636244870820207 0.0215565821708846 1.5763526821921 0.388888888888889 21.1 21 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00636244870820207 0.0215565821708846 1.5763526821921 0.388888888888889 21.1 21 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0486773927084339 0.111006297795034 1.5763526821921 0.388888888888889 21.1 21 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0486773927084339 0.111006297795034 1.5763526821921 0.388888888888889 21.1 21 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.62918926716083e-07 2.60487227771895e-06 1.57473258693805 0.388489208633094 21.1 21 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.16566816894806e-09 5.60317418984197e-08 1.57266098972795 0.387978142076503 21.1 21 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0116594682310557 0.0340062714551006 1.56908838411748 0.387096774193548 21.1 21 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0116594682310557 0.0340062714551006 1.56908838411748 0.387096774193548 21.1 21 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 8.143808255626e-10 2.27228218583447e-08 1.5637784403472 0.385786802030457 21.1 21 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00021751330266325 0.00107847188045228 1.56348449703135 0.385714285714286 21.1 21 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 8.23035581418962e-06 6.3998887014163e-05 1.55903012524493 0.384615384615385 21.1 21 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.0215992319516587 0.0573427370656909 1.55903012524493 0.384615384615385 21.1 21 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0215992319516587 0.0573427370656909 1.55903012524493 0.384615384615385 21.1 21 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0954728209662247 0.19600027333065 1.55903012524493 0.384615384615385 21.1 21 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0954728209662247 0.19600027333065 1.55903012524493 0.384615384615385 21.1 21 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0954728209662247 0.19600027333065 1.55903012524493 0.384615384615385 21.1 21 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0954728209662247 0.19600027333065 1.55903012524493 0.384615384615385 21.1 21 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0954728209662247 0.19600027333065 1.55903012524493 0.384615384615385 21.1 21 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0954728209662247 0.19600027333065 1.55903012524493 0.384615384615385 21.1 21 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00543096674735373 0.018941827650697 1.55903012524493 0.384615384615385 21.1 21 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00543096674735373 0.018941827650697 1.55903012524493 0.384615384615385 21.1 21 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 5.67025924218505e-07 7.66965877816116e-06 1.55434131283818 0.383458646616541 21.1 21 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000161334977564006 0.000847157465216165 1.54672199267721 0.381578947368421 21.1 21 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.040626560216728 0.0955563556833122 1.54418221929022 0.380952380952381 21.1 21 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.07706520002139e-05 7.86111614747977e-05 1.54418221929022 0.380952380952381 21.1 21 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.0021940673166368 0.00860098565171948 1.54032176374199 0.38 21.1 21 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0182178162105297 0.050023427494879 1.53752626144845 0.379310344827586 21.1 21 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 4.76209405976328e-07 6.57908723013898e-06 1.53068412296775 0.377622377622378 21.1 21 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.75405987794286e-07 2.77336356256965e-06 1.52328166377435 0.375796178343949 21.1 21 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00712535611621584 0.0227851275356745 1.52005437211381 0.375 21.1 21 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.11031183271266e-05 0.000142998749426196 1.52005437211381 0.375 21.1 21 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00335741810258896 0.0126058204748921 1.52005437211381 0.375 21.1 21 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0339302415389229 0.0822533794035559 1.52005437211381 0.375 21.1 21 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0781917661943598 0.166816916483619 1.52005437211381 0.375 21.1 21 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0781917661943598 0.166816916483619 1.52005437211381 0.375 21.1 21 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0781917661943598 0.166816916483619 1.52005437211381 0.375 21.1 21 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.55762793845799e-05 0.000109727948337907 1.51084192137373 0.372727272727273 21.1 21 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0283652168181366 0.071566850234412 1.50128826875438 0.37037037037037 21.1 21 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0283652168181366 0.071566850234412 1.50128826875438 0.37037037037037 21.1 21 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0283652168181366 0.071566850234412 1.50128826875438 0.37037037037037 21.1 21 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0283652168181366 0.071566850234412 1.50128826875438 0.37037037037037 21.1 21 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0283652168181366 0.071566850234412 1.50128826875438 0.37037037037037 21.1 21 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00512022761125422 0.0179460194355043 1.49802459860491 0.369565217391304 21.1 21 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00512022761125422 0.0179460194355043 1.49802459860491 0.369565217391304 21.1 21 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 8.44882461450136e-06 6.49874455482996e-05 1.4951354479808 0.368852459016393 21.1 21 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0237383210139939 0.0623240420717959 1.48627538606684 0.366666666666667 21.1 21 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0237383210139939 0.0623240420717959 1.48627538606684 0.366666666666667 21.1 21 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 4.75001847141679e-07 6.57908723013898e-06 1.48543615659983 0.366459627329193 21.1 21 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00921682063234265 0.0284501860299861 1.48297987523298 0.365853658536585 21.1 21 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00367841969148383 0.0134215159512346 1.48107861898269 0.365384615384615 21.1 21 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00367841969148383 0.0134215159512346 1.48107861898269 0.365384615384615 21.1 21 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00367841969148383 0.0134215159512346 1.48107861898269 0.365384615384615 21.1 21 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 6.03894279618663e-07 8.03122953175101e-06 1.47626679760847 0.364197530864198 21.1 21 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00777853581782549 0.0243271570742103 1.47399211841339 0.363636363636364 21.1 21 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00777853581782549 0.0243271570742103 1.47399211841339 0.363636363636364 21.1 21 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0198875567879673 0.0530956722500516 1.47399211841339 0.363636363636364 21.1 21 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.00011490576762111 0.000626478572125823 1.45925219722926 0.36 21.1 21 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0439682368802077 0.102233335098914 1.45925219722926 0.36 21.1 21 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0439682368802077 0.102233335098914 1.45925219722926 0.36 21.1 21 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.28418442829331e-07 2.22000770787525e-06 1.45671877327573 0.359375 21.1 21 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0140015569494574 0.0401697893933023 1.45509478356194 0.358974358974359 21.1 21 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 1.6626168174244e-06 1.9079868799959e-05 1.45313373937924 0.358490566037736 21.1 21 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 1.6626168174244e-06 1.9079868799959e-05 1.45313373937924 0.358490566037736 21.1 21 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00468678563752122 0.0166316607535977 1.45313373937924 0.358490566037736 21.1 21 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.125287796077651 0.241577959103656 1.44767083058458 0.357142857142857 21.1 21 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 3.95390629499978e-08 7.60325494295227e-07 1.43714231545306 0.354545454545455 21.1 21 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00832745798919935 0.0259299184215113 1.43560690699638 0.354166666666667 21.1 21 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 7.54363953589802e-25 3.57819968652763e-22 1.43247121366935 0.353393085787452 21.1 21 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0253341701487262 0.0654274484966194 1.43063940904829 0.352941176470588 21.1 21 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0253341701487262 0.0654274484966194 1.43063940904829 0.352941176470588 21.1 21 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0253341701487262 0.0654274484966194 1.43063940904829 0.352941176470588 21.1 21 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0253341701487262 0.0654274484966194 1.43063940904829 0.352941176470588 21.1 21 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.101378781736354 0.201527956474133 1.43063940904829 0.352941176470588 21.1 21 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.101378781736354 0.201527956474133 1.43063940904829 0.352941176470588 21.1 21 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.101378781736354 0.201527956474133 1.43063940904829 0.352941176470588 21.1 21 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.101378781736354 0.201527956474133 1.43063940904829 0.352941176470588 21.1 21 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 1.23590952393878e-05 8.92740737342584e-05 1.42728110057635 0.352112676056338 21.1 21 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.00171925110119059 0.00723814886684676 1.42728110057635 0.352112676056338 21.1 21 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0826491188944427 0.174131947831996 1.41871741397289 0.35 21.1 21 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0826491188944427 0.174131947831996 1.41871741397289 0.35 21.1 21 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.00355315757109595 0.0132014183385627 1.4155003676827 0.349206349206349 21.1 21 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.01483150553038 0.0422950548491597 1.41400406708261 0.348837209302326 21.1 21 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.01483150553038 0.0422950548491597 1.41400406708261 0.348837209302326 21.1 21 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 8.11624122850768e-06 6.34583036712441e-05 1.41217954570573 0.348387096774194 21.1 21 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 8.11624122850768e-06 6.34583036712441e-05 1.41217954570573 0.348387096774194 21.1 21 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0677644987668175 0.14767056928818 1.40990550456933 0.347826086956522 21.1 21 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00214557533404568 0.00843412624405251 1.40745775195723 0.347222222222222 21.1 21 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 8.56431276668101e-05 0.000476055354179182 1.40699247666733 0.347107438016529 21.1 21 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 8.56431276668101e-05 0.000476055354179182 1.40699247666733 0.347107438016529 21.1 21 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0558106512541453 0.124776188190346 1.40312711272044 0.346153846153846 21.1 21 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0558106512541453 0.124776188190346 1.40312711272044 0.346153846153846 21.1 21 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0558106512541453 0.124776188190346 1.40312711272044 0.346153846153846 21.1 21 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00738651986653423 0.0234098391315773 1.40029251249272 0.345454545454545 21.1 21 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000105851205144859 0.000579331788158208 1.39545975144874 0.344262295081967 21.1 21 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.0382493565899645 0.0911705769305184 1.39338317443766 0.34375 21.1 21 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0382493565899645 0.0911705769305184 1.39338317443766 0.34375 21.1 21 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 4.00585469157838e-05 0.000252227045403365 1.3897639973612 0.342857142857143 21.1 21 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0317936759701598 0.0782740500095804 1.3897639973612 0.342857142857143 21.1 21 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0264852956149053 0.0676635110592643 1.38671626929681 0.342105263157895 21.1 21 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.000130281190917832 0.00070759593387815 1.38411455021745 0.341463414634146 21.1 21 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.00914520961346915 0.0282905071303622 1.37528728905535 0.339285714285714 21.1 21 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 9.05441060965652e-15 6.13544109406725e-13 1.37393179202297 0.338951310861423 21.1 21 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00647305070460234 0.0216732968297627 1.3729523361028 0.338709677419355 21.1 21 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 1.93815637294892e-05 0.000131961555918963 1.36773808533758 0.337423312883436 21.1 21 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 7.27548085140004e-17 8.62750770961855e-15 1.36166612494176 0.335925349922239 21.1 21 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0001015206058462 0.000559937295035435 1.36102191955689 0.335766423357664 21.1 21 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0001015206058462 0.000559937295035435 1.36102191955689 0.335766423357664 21.1 21 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.000170958364153632 0.000884631826147705 1.35115944187894 0.333333333333333 21.1 21 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0190433411738678 0.0509373580646877 1.35115944187894 0.333333333333333 21.1 21 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0272749629102246 0.0694316139915021 1.35115944187894 0.333333333333333 21.1 21 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0474302564909633 0.109745130059578 1.35115944187894 0.333333333333333 21.1 21 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0573307945219304 0.126483287759236 1.35115944187894 0.333333333333333 21.1 21 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0695333684721497 0.150485994948802 1.35115944187894 0.333333333333333 21.1 21 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0695333684721497 0.150485994948802 1.35115944187894 0.333333333333333 21.1 21 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.127729476250314 0.245620330681347 1.35115944187894 0.333333333333333 21.1 21 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.127729476250314 0.245620330681347 1.35115944187894 0.333333333333333 21.1 21 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.158771657303645 0.294828078285027 1.35115944187894 0.333333333333333 21.1 21 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.158771657303645 0.294828078285027 1.35115944187894 0.333333333333333 21.1 21 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.158771657303645 0.294828078285027 1.35115944187894 0.333333333333333 21.1 21 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00562560241489501 0.0195249566741356 1.35115944187894 0.333333333333333 21.1 21 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0112247036633249 0.0330015564316351 1.35115944187894 0.333333333333333 21.1 21 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0327271649476291 0.0796081294367115 1.35115944187894 0.333333333333333 21.1 21 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.31542852954477e-05 9.40630551528745e-05 1.34381618404264 0.331521739130435 21.1 21 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.000175857541036921 0.000900162880919203 1.34122444598277 0.330882352941176 21.1 21 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0232117985292295 0.0611673876057288 1.32358475939162 0.326530612244898 21.1 21 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 5.13462831201798e-05 0.000305714480669522 1.31973712927711 0.325581395348837 21.1 21 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0332821492315289 0.080819963065641 1.31973712927711 0.325581395348837 21.1 21 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0480818821001341 0.110632264556923 1.31464161912546 0.324324324324324 21.1 21 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0579979499589899 0.12728445516767 1.31141945829427 0.323529411764706 21.1 21 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0851773082888207 0.178508556251829 1.30290374752612 0.321428571428571 21.1 21 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0851773082888207 0.178508556251829 1.30290374752612 0.321428571428571 21.1 21 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0401900086602991 0.0946860634496781 1.28974310361172 0.318181818181818 21.1 21 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0166158389808243 0.0461803493549083 1.28681851607518 0.317460317460317 21.1 21 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0482505461412643 0.110632264556923 1.28524922520192 0.317073170731707 21.1 21 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00996196571674556 0.0302903359293353 1.28004578704321 0.315789473684211 21.1 21 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0580495374010091 0.12728445516767 1.28004578704321 0.315789473684211 21.1 21 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.156997783020465 0.292801894152191 1.28004578704321 0.315789473684211 21.1 21 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.0013710306902198 0.00589418934194192 1.27488431209545 0.314516129032258 21.1 21 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0700082422038701 0.150485994948802 1.27395033091443 0.314285714285714 21.1 21 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0700082422038701 0.150485994948802 1.27395033091443 0.314285714285714 21.1 21 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0700082422038701 0.150485994948802 1.27395033091443 0.314285714285714 21.1 21 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00842720052398917 0.0261832016280275 1.2697642947778 0.313253012048193 21.1 21 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.195398880535138 0.343912833697587 1.26671197676151 0.3125 21.1 21 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.195398880535138 0.343912833697587 1.26671197676151 0.3125 21.1 21 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.195398880535138 0.343912833697587 1.26671197676151 0.3125 21.1 21 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.195398880535138 0.343912833697587 1.26671197676151 0.3125 21.1 21 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.195398880535138 0.343912833697587 1.26671197676151 0.3125 21.1 21 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.195398880535138 0.343912833697587 1.26671197676151 0.3125 21.1 21 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.195398880535138 0.343912833697587 1.26671197676151 0.3125 21.1 21 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.195398880535138 0.343912833697587 1.26671197676151 0.3125 21.1 21 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0480560550420922 0.110632264556923 1.26108214575368 0.311111111111111 21.1 21 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0117755438177932 0.0341971405157544 1.25107355729532 0.308641975308642 21.1 21 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.125187633842648 0.241577959103656 1.24722410019595 0.307692307692308 21.1 21 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00308116881651892 0.011629982031582 1.23949337230217 0.305785123966942 21.1 21 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.96497223965463e-05 0.000191047954252754 1.23856282172236 0.305555555555556 21.1 21 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.96497223965463e-05 0.000191047954252754 1.23856282172236 0.305555555555556 21.1 21 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.96497223965463e-05 0.000191047954252754 1.23856282172236 0.305555555555556 21.1 21 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 8.57363122137565e-09 1.93655194095517e-07 1.23581656269415 0.304878048780488 21.1 21 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.0569304327258814 0.125795040013865 1.23366731649816 0.304347826086957 21.1 21 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0569304327258814 0.125795040013865 1.23366731649816 0.304347826086957 21.1 21 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.153286058137744 0.288145390660514 1.23366731649816 0.304347826086957 21.1 21 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.153286058137744 0.288145390660514 1.23366731649816 0.304347826086957 21.1 21 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.100861511052336 0.201527956474133 1.22832676534449 0.303030303030303 21.1 21 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0469138786063652 0.108727116053514 1.22369157000357 0.30188679245283 21.1 21 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0161551948523328 0.0454176801923281 1.22092720651712 0.301204819277108 21.1 21 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.188861496217332 0.338475956067083 1.21604349769105 0.3 21.1 21 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.188861496217332 0.338475956067083 1.21604349769105 0.3 21.1 21 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.188861496217332 0.338475956067083 1.21604349769105 0.3 21.1 21 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00685202650703937 0.0219604363052185 1.21604349769105 0.3 21.1 21 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0271022002488064 0.0691154676595904 1.21604349769105 0.3 21.1 21 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.46902449295668e-09 8.8150390240667e-08 1.21391382431506 0.299474605954466 21.1 21 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 5.36416782004628e-22 1.52664216158517e-19 1.20636120601587 0.297611362169141 21.1 21 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.098480857806005 0.200197515225636 1.205088150865 0.297297297297297 21.1 21 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.148621008735489 0.280116152888214 1.2010306150035 0.296296296296296 21.1 21 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.000464603809559563 0.00215352189251876 1.19674121994992 0.295238095238095 21.1 21 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.118721328174564 0.229538654880985 1.19219950754024 0.294117647058824 21.1 21 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.234573921701298 0.396435499502312 1.19219950754024 0.294117647058824 21.1 21 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.234573921701298 0.396435499502312 1.19219950754024 0.294117647058824 21.1 21 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.234573921701298 0.396435499502312 1.19219950754024 0.294117647058824 21.1 21 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.00116025564376675 0.00509581413913606 1.18226451164407 0.291666666666667 21.1 21 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0778606655998436 0.166816916483619 1.18226451164407 0.291666666666667 21.1 21 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.181534941390617 0.326579294056698 1.18226451164407 0.291666666666667 21.1 21 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.143503423236324 0.27250244344322 1.17681628808811 0.290322580645161 21.1 21 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 8.06009052959577e-13 4.41134954754414e-11 1.17668539983451 0.29029029029029 21.1 21 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0144510251442922 0.0413758727974401 1.1743722251845 0.289719626168224 21.1 21 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.114952877230263 0.225624750756778 1.17337530478961 0.289473684210526 21.1 21 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0899697577424113 0.187447972573135 1.15813666446766 0.285714285714286 21.1 21 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0899697577424113 0.187447972573135 1.15813666446766 0.285714285714286 21.1 21 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.111051914458051 0.218269163361611 1.15813666446766 0.285714285714286 21.1 21 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.138206562562842 0.264338627052317 1.15813666446766 0.285714285714286 21.1 21 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.173998488914157 0.319812162637746 1.15813666446766 0.285714285714286 21.1 21 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.222941935410944 0.380815190591651 1.15813666446766 0.285714285714286 21.1 21 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0395940197885475 0.0934366337630235 1.15098767271169 0.283950617283951 21.1 21 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00891935168953 0.0276519334514187 1.14992292925867 0.283687943262411 21.1 21 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.10711156664318 0.210815711387614 1.14554822246258 0.282608695652174 21.1 21 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.10711156664318 0.210815711387614 1.14554822246258 0.282608695652174 21.1 21 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.0213555750283472 0.0569082083620563 1.14234389177038 0.281818181818182 21.1 21 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.166525110758284 0.307747055336413 1.14004077908536 0.28125 21.1 21 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.211749302498922 0.362598384423545 1.13497393117831 0.28 21.1 21 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0361114052446074 0.0863639154001282 1.1332304996404 0.279569892473118 21.1 21 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.081016784798369 0.172585156838442 1.12965789402993 0.278688524590164 21.1 21 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.159248556416975 0.295066010131973 1.12596620156578 0.277777777777778 21.1 21 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.275667939182446 0.446274718380683 1.12596620156578 0.277777777777778 21.1 21 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.275667939182446 0.446274718380683 1.12596620156578 0.277777777777778 21.1 21 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0781054065027028 0.166816916483619 1.12250169017635 0.276923076923077 21.1 21 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.201141871163317 0.346100220877146 1.11820091741705 0.275862068965517 21.1 21 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00247646252786709 0.00942247640950498 1.10697400057552 0.273092369477912 21.1 21 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.191148960648014 0.341286036389114 1.10549408881004 0.272727272727273 21.1 21 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.191148960648014 0.341286036389114 1.10549408881004 0.272727272727273 21.1 21 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.191148960648014 0.341286036389114 1.10549408881004 0.272727272727273 21.1 21 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.258823502142685 0.42140256698975 1.10549408881004 0.272727272727273 21.1 21 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.258823502142685 0.42140256698975 1.10549408881004 0.272727272727273 21.1 21 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.258823502142685 0.42140256698975 1.10549408881004 0.272727272727273 21.1 21 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.243640443582812 0.411269693022943 1.09132108767145 0.269230769230769 21.1 21 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 0.000235366348964872 0.00116293859228129 1.08153345459817 0.266816143497758 21.1 21 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.164629578714241 0.304639649558341 1.08092755350315 0.266666666666667 21.1 21 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.22984391670139 0.38983062391666 1.08092755350315 0.266666666666667 21.1 21 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.22984391670139 0.38983062391666 1.08092755350315 0.266666666666667 21.1 21 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0876306892959255 0.183380104217797 1.07750689668827 0.265822784810127 21.1 21 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.205613052253721 0.353366392943291 1.06670482253601 0.263157894736842 21.1 21 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.318050137811724 0.501757589918053 1.06670482253601 0.263157894736842 21.1 21 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.089506296758975 0.187030044475802 1.05943183510962 0.261363636363636 21.1 21 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.296072011791488 0.473915042496387 1.057429128427 0.260869565217391 21.1 21 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.167016215084549 0.30825431136876 1.05090178812807 0.259259259259259 21.1 21 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.276897245779375 0.447755432663694 1.05090178812807 0.259259259259259 21.1 21 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.259875392689239 0.422631638624899 1.04605892274499 0.258064516129032 21.1 21 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.15891295575869 0.294828078285027 1.01336958140921 0.25 21.1 21 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.228749178320085 0.388900932795079 1.01336958140921 0.25 21.1 21 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.273016774977951 0.443496427846603 1.01336958140921 0.25 21.1 21 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.334251035258446 0.525593702788123 1.01336958140921 0.25 21.1 21 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.361113018343188 0.539206532111602 1.01336958140921 0.25 21.1 21 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.361113018343188 0.539206532111602 1.01336958140921 0.25 21.1 21 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.136747889808168 0.261900736469748 1.00292247232251 0.247422680412371 21.1 21 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.0458223066138082 0.106370542106769 0.991623453052785 0.244635193133047 21.1 21 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.283913299318501 0.458579596969611 0.988653250155323 0.24390243902439 21.1 21 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.209948596273367 0.359948015056628 0.984416164797514 0.242857142857143 21.1 21 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.322941974992051 0.508910775651925 0.982661412275594 0.242424242424242 21.1 21 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.205929520956771 0.353483363475856 0.974887192241768 0.240506329113924 21.1 21 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.0109934814830305 0.0325218434509528 0.974472567173297 0.24040404040404 21.1 21 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.37293579297198 0.554965536640806 0.972834798152838 0.24 21.1 21 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.37293579297198 0.554965536640806 0.972834798152838 0.24 21.1 21 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.37293579297198 0.554965536640806 0.972834798152838 0.24 21.1 21 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.311734984648615 0.498425711410089 0.965113887056387 0.238095238095238 21.1 21 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.404291481759515 0.593099771694629 0.965113887056387 0.238095238095238 21.1 21 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.404291481759515 0.593099771694629 0.965113887056387 0.238095238095238 21.1 21 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.355470918577773 0.533608250690242 0.953759606032194 0.235294117647059 21.1 21 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.355470918577773 0.533608250690242 0.953759606032194 0.235294117647059 21.1 21 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.228659779627522 0.388900932795079 0.953759606032194 0.235294117647059 21.1 21 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.228659779627522 0.388900932795079 0.953759606032194 0.235294117647059 21.1 21 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.275200106426178 0.446274718380683 0.950033982571131 0.234375 21.1 21 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.222761356314117 0.380815190591651 0.948686416638406 0.234042553191489 21.1 21 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.381631397633712 0.563341783021549 0.945811609315259 0.233333333333333 21.1 21 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.340139227712028 0.526106653298061 0.942669378055075 0.232558139534884 21.1 21 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.41172439778873 0.60276112968453 0.93541807514696 0.230769230769231 21.1 21 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.41172439778873 0.60276112968453 0.93541807514696 0.230769230769231 21.1 21 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.223190350634882 0.380815190591651 0.925597412940692 0.228346456692913 21.1 21 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.134000178596159 0.256984170003146 0.921967619164454 0.227450980392157 21.1 21 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.134000178596159 0.256984170003146 0.921967619164454 0.227450980392157 21.1 21 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.447076181646818 0.636826232716138 0.921245074008369 0.227272727272727 21.1 21 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.417143565742518 0.603088447781445 0.915301557401863 0.225806451612903 21.1 21 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.450246441219975 0.640700685856024 0.900772961252628 0.222222222222222 21.1 21 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.489021784384409 0.672495719120141 0.881190940355831 0.217391304347826 21.1 21 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.489021784384409 0.672495719120141 0.881190940355831 0.217391304347826 21.1 21 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.489021784384409 0.672495719120141 0.881190940355831 0.217391304347826 21.1 21 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.392944657378157 0.578305006347851 0.872267487795266 0.215189873417722 21.1 21 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.432611555560122 0.622156888079201 0.863856036611127 0.213114754098361 21.1 21 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.456911838371681 0.649536009992909 0.857466568884713 0.211538461538462 21.1 21 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.10632932742604 0.209856633740991 0.846287182132957 0.208780487804878 21.1 21 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.529750928891242 0.724145602125108 0.844474651174338 0.208333333333333 21.1 21 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.525200734252748 0.718616004655443 0.838650688062791 0.206896551724138 21.1 21 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.506335170224478 0.693469631597143 0.822444877665442 0.202898550724638 21.1 21 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.561093068407507 0.756810840136381 0.810695665127365 0.2 21.1 21 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.568954712871058 0.766688026908632 0.810695665127365 0.2 21.1 21 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.595640949047104 0.780476123843488 0.78454419205874 0.193548387096774 21.1 21 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.601882182974321 0.787928561520202 0.776197977249605 0.191489361702128 21.1 21 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.618088955777934 0.803967627122486 0.766874277823183 0.189189189189189 21.1 21 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.628681330854001 0.816998661009355 0.760027186056905 0.1875 21.1 21 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.647794015744806 0.837624097137962 0.746693375775204 0.184210526315789 21.1 21 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.67030715647202 0.837624097137962 0.736996059206695 0.181818181818182 21.1 21 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.675292729339484 0.841454950831949 0.72383541529229 0.178571428571429 21.1 21 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.723948744218959 0.898934609968219 0.720618369002102 0.177777777777778 21.1 21 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.784626870956261 0.958091620061648 0.719165509387178 0.17741935483871 21.1 21 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.77955495651159 0.953012631542949 0.696051833695212 0.171717171717172 21.1 21 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.793493233336999 0.965903225867023 0.68909131535826 0.17 21.1 21 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.800574351910985 0.96954664065475 0.682691086423044 0.168421052631579 21.1 21 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.872121432564453 1 0.679231503214819 0.167567567567568 21.1 21 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.762581566307268 0.933064117674328 0.653786826715617 0.161290322580645 21.1 21 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.799700744659443 0.969313594250755 0.648556532101892 0.16 21.1 21 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.811590978662641 0.981218319997399 0.623612050097973 0.153846153846154 21.1 21 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.810107710249376 0.980257884085767 0.614163382672246 0.151515151515152 21.1 21 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.877501701765703 1 0.579068332233832 0.142857142857143 21.1 21 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.917510140681101 1 0.570912440230539 0.140845070422535 21.1 21 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.976367616720152 1 0.525450894064033 0.12962962962963 21.1 21 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.978858569586913 1 0.495425128688945 0.122222222222222 21.1 21 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.996326041702957 1 0.494326625077661 0.121951219512195 21.1 21 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.99606083858594 1 0.428733284442356 0.105769230769231 21.1 21 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999993600177553 1 0.373592472408924 0.0921658986175115 21.1 21 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99999999836237 1 0.36564881803425 0.0902061855670103 21.1 21 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.330132155824326 0.0814441645675903 21.1 21 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999999942865 1 0.260580749505224 0.0642857142857143 21.1 21 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.219899366671075 0.054249547920434 21.1 21 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999999205223 1 0.184249014801674 0.0454545454545455 21.1 21 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 1.50632429924631e-05 7.05098512443256e-05 2.43290831815422 1 21.2 21 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 5.17404242791552e-05 0.000224471413869628 2.43290831815422 1 21.2 21 2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.000177709364078593 0.000672554322031484 2.43290831815422 1 21.2 21 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0020959332795073 0.00614951145719359 2.43290831815422 1 21.2 21 2 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0020959332795073 0.00614951145719359 2.43290831815422 1 21.2 21 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0020959332795073 0.00614951145719359 2.43290831815422 1 21.2 21 2 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0020959332795073 0.00614951145719359 2.43290831815422 1 21.2 21 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 1.06553931856973e-07 8.2405567952431e-07 2.28085154826958 0.9375 21.2 21 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 3.43835924005541e-07 2.39842411696022e-06 2.27071443027727 0.933333333333333 21.2 21 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 1.12304756505509e-05 5.43570301045373e-05 2.23016595830803 0.916666666666667 21.2 21 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 1.12304756505509e-05 5.43570301045373e-05 2.23016595830803 0.916666666666667 21.2 21 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 1.12304756505509e-05 5.43570301045373e-05 2.23016595830803 0.916666666666667 21.2 21 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 3.54712438282663e-05 0.000155788827060565 2.21173483468565 0.909090909090909 21.2 21 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000111166866528456 0.000443110507198859 2.1896174863388 0.9 21.2 21 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000345157874572692 0.00125616280183361 2.16258517169264 0.888888888888889 21.2 21 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.3982244597909e-09 1.63087984121513e-08 2.14095931997571 0.88 21.2 21 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 2.00480986904553e-06 1.23499759465445e-05 2.12879477838494 0.875 21.2 21 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 2.00480986904553e-06 1.23499759465445e-05 2.12879477838494 0.875 21.2 21 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 2.00480986904553e-06 1.23499759465445e-05 2.12879477838494 0.875 21.2 21 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 2.00480986904553e-06 1.23499759465445e-05 2.12879477838494 0.875 21.2 21 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.00105949194267466 0.00334304107928553 2.12879477838494 0.875 21.2 21 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00105949194267466 0.00334304107928553 2.12879477838494 0.875 21.2 21 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00105949194267466 0.00334304107928553 2.12879477838494 0.875 21.2 21 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00105949194267466 0.00334304107928553 2.12879477838494 0.875 21.2 21 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00105949194267466 0.00334304107928553 2.12879477838494 0.875 21.2 21 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00105949194267466 0.00334304107928553 2.12879477838494 0.875 21.2 21 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 8.51853133848225e-11 1.49652717218028e-09 2.10852054240032 0.866666666666667 21.2 21 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 1.80976589977763e-05 8.38858917063051e-05 2.08534998698933 0.857142857142857 21.2 21 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00320600216665481 0.00896678394255941 2.08534998698933 0.857142857142857 21.2 21 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.00320600216665481 0.00896678394255941 2.08534998698933 0.857142857142857 21.2 21 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00320600216665481 0.00896678394255941 2.08534998698933 0.857142857142857 21.2 21 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00320600216665481 0.00896678394255941 2.08534998698933 0.857142857142857 21.2 21 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 3.37591115009305e-07 2.36646382590266e-06 2.06797207043109 0.85 21.2 21 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 5.35703311796391e-05 0.00023100176142008 2.05861473074588 0.846153846153846 21.2 21 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 1.91620307570301e-08 1.74792113892653e-07 2.04364298724954 0.84 21.2 21 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 1.91620307570301e-08 1.74792113892653e-07 2.04364298724954 0.84 21.2 21 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 2.87848629388307e-06 1.61900632260696e-05 2.02742359846185 0.833333333333333 21.2 21 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000156675084716844 0.000604196871414821 2.02742359846185 0.833333333333333 21.2 21 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.000156675084716844 0.000604196871414821 2.02742359846185 0.833333333333333 21.2 21 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.000156675084716844 0.000604196871414821 2.02742359846185 0.833333333333333 21.2 21 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000156675084716844 0.000604196871414821 2.02742359846185 0.833333333333333 21.2 21 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000156675084716844 0.000604196871414821 2.02742359846185 0.833333333333333 21.2 21 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00952398656909641 0.023224354025924 2.02742359846185 0.833333333333333 21.2 21 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.00952398656909641 0.023224354025924 2.02742359846185 0.833333333333333 21.2 21 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00952398656909641 0.023224354025924 2.02742359846185 0.833333333333333 21.2 21 2 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.00952398656909641 0.023224354025924 2.02742359846185 0.833333333333333 21.2 21 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00952398656909641 0.023224354025924 2.02742359846185 0.833333333333333 21.2 21 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.00952398656909641 0.023224354025924 2.02742359846185 0.833333333333333 21.2 21 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.000451797168679306 0.00158351569219373 1.99056135121709 0.818181818181818 21.2 21 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000451797168679306 0.00158351569219373 1.99056135121709 0.818181818181818 21.2 21 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 7.20670361626985e-08 5.69729958108444e-07 1.96504133389379 0.807692307692308 21.2 21 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 2.01014269476029e-07 1.46688874597122e-06 1.94632665452338 0.8 21.2 21 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00128112190674964 0.00391209543627626 1.94632665452338 0.8 21.2 21 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00128112190674964 0.00391209543627626 1.94632665452338 0.8 21.2 21 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00128112190674964 0.00391209543627626 1.94632665452338 0.8 21.2 21 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00128112190674964 0.00391209543627626 1.94632665452338 0.8 21.2 21 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00128112190674964 0.00391209543627626 1.94632665452338 0.8 21.2 21 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.00128112190674964 0.00391209543627626 1.94632665452338 0.8 21.2 21 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.35289686865343e-08 1.26656068690384e-07 1.90070962355798 0.78125 21.2 21 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00355966118103155 0.00974114973193825 1.89226202523106 0.777777777777778 21.2 21 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 4.11456650573596e-06 2.15258387414054e-05 1.87997460948281 0.772727272727273 21.2 21 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000500357596507525 0.00171982816384108 1.87146793704171 0.769230769230769 21.2 21 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000500357596507525 0.00171982816384108 1.87146793704171 0.769230769230769 21.2 21 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.000500357596507525 0.00171982816384108 1.87146793704171 0.769230769230769 21.2 21 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 7.33021679043506e-05 0.000302397884110049 1.86045930211793 0.764705882352941 21.2 21 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 1.10033002719657e-05 5.39920561620938e-05 1.85364443287941 0.761904761904762 21.2 21 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 6.79254062720755e-07 4.43384647363135e-06 1.82468123861567 0.75 21.2 21 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.90373428189057e-05 0.000129530215772109 1.82468123861567 0.75 21.2 21 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 2.90373428189057e-05 0.000129530215772109 1.82468123861567 0.75 21.2 21 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 2.90373428189057e-05 0.000129530215772109 1.82468123861567 0.75 21.2 21 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 2.90373428189057e-05 0.000129530215772109 1.82468123861567 0.75 21.2 21 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0096455328385953 0.023224354025924 1.82468123861567 0.75 21.2 21 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0096455328385953 0.023224354025924 1.82468123861567 0.75 21.2 21 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0096455328385953 0.023224354025924 1.82468123861567 0.75 21.2 21 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0096455328385953 0.023224354025924 1.82468123861567 0.75 21.2 21 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0096455328385953 0.023224354025924 1.82468123861567 0.75 21.2 21 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0096455328385953 0.023224354025924 1.82468123861567 0.75 21.2 21 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0096455328385953 0.023224354025924 1.82468123861567 0.75 21.2 21 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0096455328385953 0.023224354025924 1.82468123861567 0.75 21.2 21 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0013371634205667 0.0040313210751407 1.82468123861566 0.75 21.2 21 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.14652313702853e-05 5.53051669149692e-05 1.79823658298355 0.739130434782609 21.2 21 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 7.5507715121661e-05 0.000308757122465873 1.792669287061 0.736842105263158 21.2 21 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.10234499879576e-09 1.35227321835032e-08 1.78413276664643 0.733333333333333 21.2 21 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.79424590795468e-09 3.01228176289357e-08 1.76938786774852 0.727272727272727 21.2 21 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00349265454160386 0.00957619925376164 1.76938786774852 0.727272727272727 21.2 21 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00349265454160386 0.00957619925376164 1.76938786774852 0.727272727272727 21.2 21 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00349265454160386 0.00957619925376164 1.76938786774852 0.727272727272727 21.2 21 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00349265454160386 0.00957619925376164 1.76938786774852 0.727272727272727 21.2 21 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00349265454160386 0.00957619925376164 1.76938786774852 0.727272727272727 21.2 21 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.11006861123547e-07 8.53852775020581e-07 1.75710045200027 0.722222222222222 21.2 21 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 4.47187010338808e-06 2.30560549171059e-05 1.73779165582444 0.714285714285714 21.2 21 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 4.47187010338808e-06 2.30560549171059e-05 1.73779165582444 0.714285714285714 21.2 21 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 7.41224491862555e-05 0.000303966124472742 1.73779165582444 0.714285714285714 21.2 21 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 7.41224491862555e-05 0.000303966124472742 1.73779165582444 0.714285714285714 21.2 21 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00129215959816016 0.00392056099825568 1.73779165582444 0.714285714285714 21.2 21 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00129215959816016 0.00392056099825568 1.73779165582444 0.714285714285714 21.2 21 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00129215959816016 0.00392056099825568 1.73779165582444 0.714285714285714 21.2 21 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0253189475752004 0.0529058185014834 1.73779165582444 0.714285714285714 21.2 21 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0253189475752004 0.0529058185014834 1.73779165582444 0.714285714285714 21.2 21 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0253189475752004 0.0529058185014834 1.73779165582444 0.714285714285714 21.2 21 2 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0253189475752004 0.0529058185014834 1.73779165582444 0.714285714285714 21.2 21 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0253189475752004 0.0529058185014834 1.73779165582444 0.714285714285714 21.2 21 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.95892506896122e-09 6.97362702333227e-08 1.73006813735411 0.711111111111111 21.2 21 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 2.85892662944091e-05 0.000129150875990299 1.72331005869257 0.708333333333333 21.2 21 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 2.85892662944091e-05 0.000129150875990299 1.72331005869257 0.708333333333333 21.2 21 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 2.85892662944091e-05 0.000129150875990299 1.72331005869257 0.708333333333333 21.2 21 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.000485001859227641 0.00168742700655485 1.71734704810886 0.705882352941177 21.2 21 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000485001859227641 0.00168742700655485 1.71734704810886 0.705882352941177 21.2 21 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000485001859227641 0.00168742700655485 1.71734704810886 0.705882352941177 21.2 21 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 1.10731457165309e-05 5.41480630743077e-05 1.71204659425667 0.703703703703704 21.2 21 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.69443436702319e-07 1.90755229068358e-06 1.70961125059486 0.702702702702703 21.2 21 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.69443436702319e-07 1.90755229068358e-06 1.70961125059486 0.702702702702703 21.2 21 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.50416102529835e-12 1.20932474320746e-10 1.70666702915296 0.701492537313433 21.2 21 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.7089978465146e-14 2.00747249776942e-12 1.70303582270795 0.7 21.2 21 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 6.90261111282932e-11 1.29242310704686e-09 1.70303582270795 0.7 21.2 21 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 6.90261111282932e-11 1.29242310704686e-09 1.70303582270795 0.7 21.2 21 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 6.90261111282932e-11 1.29242310704686e-09 1.70303582270795 0.7 21.2 21 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 6.90261111282932e-11 1.29242310704686e-09 1.70303582270795 0.7 21.2 21 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 6.90261111282932e-11 1.29242310704686e-09 1.70303582270795 0.7 21.2 21 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 6.90261111282932e-11 1.29242310704686e-09 1.70303582270795 0.7 21.2 21 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 6.90261111282932e-11 1.29242310704686e-09 1.70303582270795 0.7 21.2 21 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.30387645201322e-06 2.23518839095431e-05 1.70303582270795 0.7 21.2 21 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00887625282102266 0.0219667961118526 1.70303582270795 0.7 21.2 21 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00887625282102266 0.0219667961118526 1.70303582270795 0.7 21.2 21 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00887625282102266 0.0219667961118526 1.70303582270795 0.7 21.2 21 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00887625282102266 0.0219667961118526 1.70303582270795 0.7 21.2 21 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.74547129821357e-11 5.91940251114835e-10 1.69917406347279 0.698412698412698 21.2 21 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 7.03058869513434e-05 0.00029253005009287 1.69245796045511 0.695652173913043 21.2 21 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.49415750990942e-09 6.60084724042936e-08 1.68814046565803 0.693877551020408 21.2 21 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.88682755577551e-13 2.27905944462059e-11 1.68681643392026 0.693333333333333 21.2 21 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.88682755577551e-13 2.27905944462059e-11 1.68681643392026 0.693333333333333 21.2 21 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.88682755577551e-13 2.27905944462059e-11 1.68681643392026 0.693333333333333 21.2 21 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.88682755577551e-13 2.27905944462059e-11 1.68681643392026 0.693333333333333 21.2 21 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.88682755577551e-13 2.27905944462059e-11 1.68681643392026 0.693333333333333 21.2 21 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 2.56571967545116e-09 2.80847622935923e-08 1.68432114333754 0.692307692307692 21.2 21 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.70365643195894e-05 0.000123310996880691 1.68432114333754 0.692307692307692 21.2 21 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 2.70365643195894e-05 0.000123310996880691 1.68432114333754 0.692307692307692 21.2 21 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00321997652469983 0.00896678394255941 1.68432114333754 0.692307692307692 21.2 21 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00321997652469983 0.00896678394255941 1.68432114333754 0.692307692307692 21.2 21 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00321997652469983 0.00896678394255941 1.68432114333754 0.692307692307692 21.2 21 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00321997652469983 0.00896678394255941 1.68432114333754 0.692307692307692 21.2 21 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.58997705374379e-10 2.26253734747742e-09 1.67511720266356 0.688524590163934 21.2 21 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.58997705374379e-10 2.26253734747742e-09 1.67511720266356 0.688524590163934 21.2 21 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00119267380237694 0.00371373046123062 1.67262446873103 0.6875 21.2 21 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00119267380237694 0.00371373046123062 1.67262446873103 0.6875 21.2 21 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00119267380237694 0.00371373046123062 1.67262446873103 0.6875 21.2 21 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00119267380237694 0.00371373046123062 1.67262446873103 0.6875 21.2 21 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00119267380237694 0.00371373046123062 1.67262446873103 0.6875 21.2 21 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.14538957331435e-09 6.29128731138585e-08 1.66964296343917 0.686274509803922 21.2 21 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.14538957331435e-09 6.29128731138585e-08 1.66964296343917 0.686274509803922 21.2 21 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 4.13139039690585e-14 1.83717766712407e-12 1.66908826478022 0.686046511627907 21.2 21 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000448022519406946 0.00157805951761407 1.66462148084236 0.684210526315789 21.2 21 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000448022519406946 0.00157805951761407 1.66462148084236 0.684210526315789 21.2 21 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000448022519406946 0.00157805951761407 1.66462148084236 0.684210526315789 21.2 21 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000448022519406946 0.00157805951761407 1.66462148084236 0.684210526315789 21.2 21 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 3.78628597415208e-10 5.02028202706285e-09 1.66248735073872 0.683333333333333 21.2 21 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.40966602783174e-07 1.72309284301737e-06 1.66149836361752 0.682926829268293 21.2 21 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.40966602783174e-07 1.72309284301737e-06 1.66149836361752 0.682926829268293 21.2 21 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 2.40966602783174e-07 1.72309284301737e-06 1.66149836361752 0.682926829268293 21.2 21 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000170013575338422 0.00064514484721753 1.65880112601424 0.681818181818182 21.2 21 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.71042371628648e-08 3.10584291075039e-07 1.65644821661564 0.680851063829787 21.2 21 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.71042371628648e-08 3.10584291075039e-07 1.65644821661564 0.680851063829787 21.2 21 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.46041944246927e-06 9.31917877414248e-06 1.64385697172582 0.675675675675676 21.2 21 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 5.70128888858943e-07 3.80888924340975e-06 1.6422131147541 0.675 21.2 21 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 5.70128888858943e-07 3.80888924340975e-06 1.6422131147541 0.675 21.2 21 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 8.74724804414809e-08 6.87534172115568e-07 1.63956864919089 0.673913043478261 21.2 21 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.67102034517197e-30 6.52982743897465e-28 1.63352415647498 0.671428571428571 21.2 21 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.19069829059228e-12 8.90267385786826e-11 1.63220431471106 0.670886075949367 21.2 21 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.19069829059228e-12 8.90267385786826e-11 1.63220431471106 0.670886075949367 21.2 21 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 3.19069829059228e-12 8.90267385786826e-11 1.63220431471106 0.670886075949367 21.2 21 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.93628252099585e-12 8.70485422370227e-11 1.62193887876948 0.666666666666667 21.2 21 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.93628252099585e-12 8.70485422370227e-11 1.62193887876948 0.666666666666667 21.2 21 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.19080100325345e-10 1.74691734807182e-09 1.62193887876948 0.666666666666667 21.2 21 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.42200047547441e-06 1.81022553033461e-05 1.62193887876948 0.666666666666667 21.2 21 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 2.27355841627656e-05 0.000104701411856361 1.62193887876948 0.666666666666667 21.2 21 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 5.89634015257064e-05 0.00025121233644036 1.62193887876948 0.666666666666667 21.2 21 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 5.89634015257064e-05 0.00025121233644036 1.62193887876948 0.666666666666667 21.2 21 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 5.89634015257064e-05 0.00025121233644036 1.62193887876948 0.666666666666667 21.2 21 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 5.89634015257064e-05 0.00025121233644036 1.62193887876948 0.666666666666667 21.2 21 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000403570853111758 0.00145020536358089 1.62193887876948 0.666666666666667 21.2 21 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000403570853111758 0.00145020536358089 1.62193887876948 0.666666666666667 21.2 21 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000403570853111758 0.00145020536358089 1.62193887876948 0.666666666666667 21.2 21 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00106871763946995 0.00336456902868526 1.62193887876948 0.666666666666667 21.2 21 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0028637709884295 0.00815029223307035 1.62193887876948 0.666666666666667 21.2 21 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0028637709884295 0.00815029223307035 1.62193887876948 0.666666666666667 21.2 21 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0028637709884295 0.00815029223307035 1.62193887876948 0.666666666666667 21.2 21 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0028637709884295 0.00815029223307035 1.62193887876948 0.666666666666667 21.2 21 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0028637709884295 0.00815029223307035 1.62193887876948 0.666666666666667 21.2 21 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0218172761537228 0.0470356977417871 1.62193887876948 0.666666666666667 21.2 21 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000153739128265212 0.000601018625058783 1.62193887876948 0.666666666666667 21.2 21 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00780363678367817 0.0196541152976532 1.62193887876948 0.666666666666667 21.2 21 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.42088424564233e-18 1.56587194615865e-16 1.60946242585587 0.661538461538462 21.2 21 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.75664456140955e-09 2.01589129910144e-08 1.60885872652134 0.661290322580645 21.2 21 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.12760765529073e-08 1.09903129690322e-07 1.60745728163761 0.660714285714286 21.2 21 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.85060951793799e-07 1.37157153334675e-06 1.6046842098464 0.659574468085106 21.2 21 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 5.54094349578506e-18 3.28531774770922e-16 1.60307912436518 0.65891472868217 21.2 21 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 9.86772224409481e-11 1.69177936787312e-09 1.59972053796442 0.657534246575342 21.2 21 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.58969974074984e-09 1.83914043177806e-08 1.59659608378871 0.65625 21.2 21 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.01800599841415e-08 1.00598787204399e-07 1.59397441534242 0.655172413793103 21.2 21 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 5.26758186894345e-05 0.000227834923997159 1.59397441534242 0.655172413793103 21.2 21 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 2.57990177371482e-08 2.2115663999977e-07 1.59244908097367 0.654545454545455 21.2 21 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.57990177371482e-08 2.2115663999977e-07 1.59244908097367 0.654545454545455 21.2 21 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.57990177371482e-08 2.2115663999977e-07 1.59244908097367 0.654545454545455 21.2 21 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.57990177371482e-08 2.2115663999977e-07 1.59244908097367 0.654545454545455 21.2 21 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000136743196616898 0.00053752919554101 1.59074774648545 0.653846153846154 21.2 21 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 7.194570304563e-17 3.6563834083547e-15 1.58923849814913 0.653225806451613 21.2 21 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 7.194570304563e-17 3.6563834083547e-15 1.58923849814913 0.653225806451613 21.2 21 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 7.194570304563e-17 3.6563834083547e-15 1.58923849814913 0.653225806451613 21.2 21 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.61141021627802e-09 3.8066938798249e-08 1.58332128641783 0.650793650793651 21.2 21 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000938464114053393 0.00304199187767193 1.58139040680024 0.65 21.2 21 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000938464114053393 0.00304199187767193 1.58139040680024 0.65 21.2 21 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000938464114053393 0.00304199187767193 1.58139040680024 0.65 21.2 21 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000938464114053393 0.00304199187767193 1.58139040680024 0.65 21.2 21 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.89943490058846e-23 5.36299681810568e-21 1.58070314456348 0.649717514124294 21.2 21 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 5.84948823177514e-08 4.70272415469832e-07 1.57688502102588 0.648148148148148 21.2 21 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 5.84948823177514e-08 4.70272415469832e-07 1.57688502102588 0.648148148148148 21.2 21 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.13050367038826e-11 2.63722413600408e-10 1.57423479409979 0.647058823529412 21.2 21 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.13050367038826e-11 2.63722413600408e-10 1.57423479409979 0.647058823529412 21.2 21 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.13050367038826e-11 2.63722413600408e-10 1.57423479409979 0.647058823529412 21.2 21 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.13050367038826e-11 2.63722413600408e-10 1.57423479409979 0.647058823529412 21.2 21 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.51911099924728e-32 3.08813564561268e-30 1.57203306711503 0.646153846153846 21.2 21 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.7640897517494e-07 2.60014549356281e-06 1.57125328880793 0.645833333333333 21.2 21 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.6009015176467e-12 5.17746104457102e-11 1.56961826977692 0.645161290322581 21.2 21 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000120081014652279 0.000474653566250536 1.564012490242 0.642857142857143 21.2 21 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00669004699247123 0.0172462624461713 1.564012490242 0.642857142857143 21.2 21 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00669004699247123 0.0172462624461713 1.564012490242 0.642857142857143 21.2 21 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00669004699247123 0.0172462624461713 1.564012490242 0.642857142857143 21.2 21 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00669004699247123 0.0172462624461713 1.564012490242 0.642857142857143 21.2 21 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00669004699247123 0.0172462624461713 1.564012490242 0.642857142857143 21.2 21 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00669004699247123 0.0172462624461713 1.564012490242 0.642857142857143 21.2 21 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00669004699247123 0.0172462624461713 1.564012490242 0.642857142857143 21.2 21 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 7.2153288900457e-09 7.18000909827624e-08 1.55858189131755 0.640625 21.2 21 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.14408914305336e-14 5.42679616854979e-13 1.55791497566016 0.640350877192982 21.2 21 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 5.05394377509187e-13 1.89256894525151e-11 1.5570613236187 0.64 21.2 21 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 3.32626422917481e-07 2.34320494956226e-06 1.5570613236187 0.64 21.2 21 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.81849793802459e-08 1.69132193843725e-07 1.55546597390188 0.639344262295082 21.2 21 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.00743160776703e-09 1.25752208583551e-08 1.55435809215408 0.638888888888889 21.2 21 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.58696460715754e-05 7.40410044585306e-05 1.55435809215408 0.638888888888889 21.2 21 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 4.58577851357403e-08 3.75032346253784e-07 1.55202772020183 0.637931034482759 21.2 21 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.53205660027822e-09 2.79311359860148e-08 1.55141979708385 0.63768115942029 21.2 21 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.53205660027822e-09 2.79311359860148e-08 1.55141979708385 0.63768115942029 21.2 21 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000812296089215103 0.00266335791463846 1.54821438427996 0.636363636363636 21.2 21 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000812296089215103 0.00266335791463846 1.54821438427996 0.636363636363636 21.2 21 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0182975498100055 0.0408750602506089 1.54821438427996 0.636363636363636 21.2 21 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0182975498100055 0.0408750602506089 1.54821438427996 0.636363636363636 21.2 21 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0182975498100055 0.0408750602506089 1.54821438427996 0.636363636363636 21.2 21 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0182975498100055 0.0408750602506089 1.54821438427996 0.636363636363636 21.2 21 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 5.43508755303412e-06 2.70424111467397e-05 1.54281990907341 0.634146341463415 21.2 21 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 5.43508755303412e-06 2.70424111467397e-05 1.54281990907341 0.634146341463415 21.2 21 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 5.43508755303412e-06 2.70424111467397e-05 1.54281990907341 0.634146341463415 21.2 21 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 5.43508755303412e-06 2.70424111467397e-05 1.54281990907341 0.634146341463415 21.2 21 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 5.43508755303412e-06 2.70424111467397e-05 1.54281990907341 0.634146341463415 21.2 21 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 5.43508755303412e-06 2.70424111467397e-05 1.54281990907341 0.634146341463415 21.2 21 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 6.73927061954431e-22 6.39332139440771e-20 1.54217139292836 0.633879781420765 21.2 21 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 4.02813378789636e-08 3.33257812800961e-07 1.54084193483101 0.633333333333333 21.2 21 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.46470587924296e-12 7.62451405687551e-11 1.53918689515879 0.63265306122449 21.2 21 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 1.86708250852645e-06 1.17560106620935e-05 1.53379002666244 0.630434782608696 21.2 21 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000268968848271925 0.000988999150105811 1.53183116328229 0.62962962962963 21.2 21 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 3.5250429677222e-05 0.000155298332602746 1.52925665712551 0.628571428571429 21.2 21 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 3.5250429677222e-05 0.000155298332602746 1.52925665712551 0.628571428571429 21.2 21 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 8.84179574821848e-08 6.87534172115568e-07 1.52572216562214 0.627118644067797 21.2 21 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 8.84179574821848e-08 6.87534172115568e-07 1.52572216562214 0.627118644067797 21.2 21 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.22488209025214e-08 1.1620048096192e-07 1.52510670690265 0.626865671641791 21.2 21 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.22488209025214e-08 1.1620048096192e-07 1.52510670690265 0.626865671641791 21.2 21 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.22488209025214e-08 1.1620048096192e-07 1.52510670690265 0.626865671641791 21.2 21 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.22488209025214e-08 1.1620048096192e-07 1.52510670690265 0.626865671641791 21.2 21 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 4.26389063425304e-09 4.46140909745741e-08 1.52056769884639 0.625 21.2 21 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00564893296518374 0.0148310546299935 1.52056769884639 0.625 21.2 21 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00564893296518374 0.0148310546299935 1.52056769884639 0.625 21.2 21 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00564893296518374 0.0148310546299935 1.52056769884639 0.625 21.2 21 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0514413054695422 0.0960642751747488 1.52056769884639 0.625 21.2 21 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0514413054695422 0.0960642751747488 1.52056769884639 0.625 21.2 21 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0514413054695422 0.0960642751747488 1.52056769884639 0.625 21.2 21 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0514413054695422 0.0960642751747488 1.52056769884639 0.625 21.2 21 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0514413054695422 0.0960642751747488 1.52056769884639 0.625 21.2 21 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000695676095729156 0.00230485732737669 1.52056769884639 0.625 21.2 21 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000695676095729156 0.00230485732737669 1.52056769884639 0.625 21.2 21 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000695676095729156 0.00230485732737669 1.52056769884639 0.625 21.2 21 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000695676095729156 0.00230485732737669 1.52056769884639 0.625 21.2 21 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000695676095729156 0.00230485732737669 1.52056769884639 0.625 21.2 21 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000695676095729156 0.00230485732737669 1.52056769884639 0.625 21.2 21 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 5.57486622984359e-07 3.75973205927366e-06 1.51482970752999 0.622641509433962 21.2 21 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 5.57486622984359e-07 3.75973205927366e-06 1.51482970752999 0.622641509433962 21.2 21 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 7.15198223674377e-14 2.9077916351104e-12 1.51290097095304 0.621848739495798 21.2 21 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000230380426227842 0.000853727464901612 1.51008102506124 0.620689655172414 21.2 21 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000230380426227842 0.000853727464901612 1.51008102506124 0.620689655172414 21.2 21 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 4.81253053221522e-07 3.29028719425171e-06 1.50397968758624 0.618181818181818 21.2 21 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 4.81253053221522e-07 3.29028719425171e-06 1.50397968758624 0.618181818181818 21.2 21 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 9.45492054514872e-19 6.72717596787332e-17 1.50267866709525 0.617647058823529 21.2 21 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 7.71166509050275e-05 0.000314432648246 1.50267866709525 0.617647058823529 21.2 21 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.02231555286766e-18 1.37035953891937e-16 1.49717434963337 0.615384615384615 21.2 21 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.2045250479263e-06 7.75583322714539e-06 1.49717434963337 0.615384615384615 21.2 21 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.2045250479263e-06 7.75583322714539e-06 1.49717434963337 0.615384615384615 21.2 21 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.000591049413908815 0.00201693840765526 1.49717434963337 0.615384615384615 21.2 21 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000591049413908815 0.00201693840765526 1.49717434963337 0.615384615384615 21.2 21 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000591049413908815 0.00201693840765526 1.49717434963337 0.615384615384615 21.2 21 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0151374931980435 0.0345202769564358 1.49717434963337 0.615384615384615 21.2 21 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0151374931980435 0.0345202769564358 1.49717434963337 0.615384615384615 21.2 21 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0151374931980435 0.0345202769564358 1.49717434963337 0.615384615384615 21.2 21 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 9.62979346575634e-10 1.21267222139569e-08 1.49491956898633 0.614457831325301 21.2 21 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.98256775232484e-08 1.78153747057164e-07 1.49450082400902 0.614285714285714 21.2 21 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 6.87236591757901e-09 6.93572815653541e-08 1.49218376846792 0.613333333333333 21.2 21 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 3.01405329924473e-06 1.68195993914715e-05 1.48953570499238 0.612244897959184 21.2 21 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.95535168915775e-12 1.30582693586509e-10 1.48677730553869 0.611111111111111 21.2 21 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.03237862884545e-06 6.70810405866247e-06 1.48677730553869 0.611111111111111 21.2 21 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 6.57059467718097e-05 0.000274192264681188 1.48677730553869 0.611111111111111 21.2 21 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00472362979036324 0.0126348217888851 1.48677730553869 0.611111111111111 21.2 21 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00472362979036324 0.0126348217888851 1.48677730553869 0.611111111111111 21.2 21 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00472362979036324 0.0126348217888851 1.48677730553869 0.611111111111111 21.2 21 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00472362979036324 0.0126348217888851 1.48677730553869 0.611111111111111 21.2 21 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00472362979036324 0.0126348217888851 1.48677730553869 0.611111111111111 21.2 21 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 3.54760612835197e-07 2.46255781494871e-06 1.48448643141613 0.610169491525424 21.2 21 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.04965127552472e-09 2.31480457545371e-08 1.48348068180135 0.609756097560976 21.2 21 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.22237426714195e-07 9.25233288373935e-07 1.48255350637523 0.609375 21.2 21 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 7.12260976006464e-10 9.04953007908213e-09 1.48211656163418 0.609195402298851 21.2 21 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 7.12260976006464e-10 9.04953007908213e-09 1.48211656163418 0.609195402298851 21.2 21 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.09946486440068e-26 1.42230772912925e-24 1.48211656163418 0.609195402298851 21.2 21 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.03486876623781e-22 1.05187018168314e-20 1.48186233923939 0.609090909090909 21.2 21 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00152058813078318 0.00454579182795057 1.48090071539822 0.608695652173913 21.2 21 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.74999542022739e-17 2.70369739319343e-15 1.47765597237588 0.607361963190184 21.2 21 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000499068227502282 0.00171982816384108 1.47712290745078 0.607142857142857 21.2 21 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000165977551884477 0.000636620097928868 1.47448988979044 0.606060606060606 21.2 21 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000165977551884477 0.000636620097928868 1.47448988979044 0.606060606060606 21.2 21 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 8.98699572944758e-12 2.243595600527e-10 1.47313714677228 0.605504587155963 21.2 21 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.28333653445301e-09 1.53461167103079e-08 1.46527432797925 0.602272727272727 21.2 21 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.803164926113e-10 5.02028202706285e-09 1.45974499089253 0.6 21.2 21 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.803164926113e-10 5.02028202706285e-09 1.45974499089253 0.6 21.2 21 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.09373676423966e-09 1.35227321835032e-08 1.45974499089253 0.6 21.2 21 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.14894536367318e-09 3.369134776321e-08 1.45974499089253 0.6 21.2 21 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 5.43489602863127e-06 2.70424111467397e-05 1.45974499089253 0.6 21.2 21 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 5.43489602863127e-06 2.70424111467397e-05 1.45974499089253 0.6 21.2 21 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000139915982746737 0.000548486070106355 1.45974499089253 0.6 21.2 21 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00127197570365221 0.00391209543627626 1.45974499089253 0.6 21.2 21 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00127197570365221 0.00391209543627626 1.45974499089253 0.6 21.2 21 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00392421987072193 0.0106771794952912 1.45974499089253 0.6 21.2 21 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0124294609985338 0.0289478281520682 1.45974499089253 0.6 21.2 21 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0124294609985338 0.0289478281520682 1.45974499089253 0.6 21.2 21 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0124294609985338 0.0289478281520682 1.45974499089253 0.6 21.2 21 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0124294609985338 0.0289478281520682 1.45974499089253 0.6 21.2 21 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0124294609985338 0.0289478281520682 1.45974499089253 0.6 21.2 21 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0412288111527729 0.0789617742535611 1.45974499089253 0.6 21.2 21 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.19661812672776e-07 1.59478958894572e-06 1.45974499089253 0.6 21.2 21 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.67802737185141e-09 2.90903278636989e-08 1.45415209820712 0.597701149425287 21.2 21 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 9.05858777296592e-28 1.28903704009305e-25 1.45310223780542 0.597269624573379 21.2 21 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.43483667204393e-08 5.11551541023381e-07 1.45298691223099 0.597222222222222 21.2 21 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.43483667204393e-08 5.11551541023381e-07 1.45298691223099 0.597222222222222 21.2 21 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.64817821339848e-39 7.81785865888679e-37 1.45060730706848 0.596244131455399 21.2 21 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 9.58251704907871e-11 1.6629172879072e-09 1.45038765120732 0.596153846153846 21.2 21 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.88801343651846e-08 1.74457345465309e-07 1.44742646776264 0.594936708860759 21.2 21 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000351033103554138 0.00127428598560596 1.44453931390407 0.59375 21.2 21 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00105953023665339 0.00334304107928553 1.44172344779509 0.592592592592593 21.2 21 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00105953023665339 0.00334304107928553 1.44172344779509 0.592592592592593 21.2 21 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 8.04318386015014e-21 6.73261801940803e-19 1.44010716590295 0.591928251121076 21.2 21 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.3329790769354e-07 1.00361334734343e-06 1.43918520228841 0.591549295774648 21.2 21 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00324542171422685 0.00900240760106201 1.43762764254568 0.590909090909091 21.2 21 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00324542171422685 0.00900240760106201 1.43762764254568 0.590909090909091 21.2 21 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.84313791383866e-11 1.20504134078151e-09 1.43762764254568 0.590909090909091 21.2 21 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.37952131118814e-09 1.62236266596755e-08 1.4341354296488 0.589473684210526 21.2 21 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.12449287186607e-07 8.55696982174024e-07 1.43308298192646 0.589041095890411 21.2 21 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.12449287186607e-07 8.55696982174024e-07 1.43308298192646 0.589041095890411 21.2 21 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000292921696140832 0.00107153617894191 1.43112254009072 0.588235294117647 21.2 21 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0101615909657072 0.0240598068955098 1.43112254009072 0.588235294117647 21.2 21 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0101615909657072 0.0240598068955098 1.43112254009072 0.588235294117647 21.2 21 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0101615909657072 0.0240598068955098 1.43112254009072 0.588235294117647 21.2 21 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0101615909657072 0.0240598068955098 1.43112254009072 0.588235294117647 21.2 21 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0101615909657072 0.0240598068955098 1.43112254009072 0.588235294117647 21.2 21 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0101615909657072 0.0240598068955098 1.43112254009072 0.588235294117647 21.2 21 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0101615909657072 0.0240598068955098 1.43112254009072 0.588235294117647 21.2 21 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0101615909657072 0.0240598068955098 1.43112254009072 0.588235294117647 21.2 21 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 9.5224167317779e-06 4.68871938038752e-05 1.43112254009072 0.588235294117647 21.2 21 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 6.16883052679332e-46 4.38912291981344e-43 1.42921800439098 0.58745247148289 21.2 21 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000879709279307742 0.00287776161943659 1.42618763478006 0.586206896551724 21.2 21 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.59515487082451e-19 4.19047651641225e-17 1.42498915777604 0.585714285714286 21.2 21 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.32572859858717e-08 2.04290851591947e-07 1.41919651892329 0.583333333333333 21.2 21 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.32572859858717e-08 2.04290851591947e-07 1.41919651892329 0.583333333333333 21.2 21 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000243810033111634 0.000901147213293129 1.41919651892329 0.583333333333333 21.2 21 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 2.33451503459117e-05 0.000107161770781395 1.41919651892329 0.583333333333333 21.2 21 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0329890280468638 0.066210700861336 1.41919651892329 0.583333333333333 21.2 21 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0329890280468638 0.066210700861336 1.41919651892329 0.583333333333333 21.2 21 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.10954779988004e-11 4.61828695266047e-10 1.41587287367991 0.581967213114754 21.2 21 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.04718345624343e-10 2.88429906755881e-09 1.41551029419882 0.581818181818182 21.2 21 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.95361972924842e-08 1.7707011940895e-07 1.41448158032222 0.581395348837209 21.2 21 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.92796605332308e-07 1.41417303808183e-06 1.41371699568421 0.581081081081081 21.2 21 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.92796605332308e-07 1.41417303808183e-06 1.41371699568421 0.581081081081081 21.2 21 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.92304355545329e-06 1.20550263410133e-05 1.41265644279922 0.580645161290323 21.2 21 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000728561718931316 0.00239986881027607 1.41265644279922 0.580645161290323 21.2 21 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.000728561718931316 0.00239986881027607 1.41265644279922 0.580645161290323 21.2 21 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.91786410903292e-10 6.36192784286713e-09 1.40972257687441 0.579439252336449 21.2 21 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.61534711431379e-07 1.20347588673745e-06 1.40852586840507 0.578947368421053 21.2 21 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.61534711431379e-07 1.20347588673745e-06 1.40852586840507 0.578947368421053 21.2 21 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00828606692912158 0.0206498655694221 1.40852586840507 0.578947368421053 21.2 21 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00828606692912158 0.0206498655694221 1.40852586840507 0.578947368421053 21.2 21 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00220051155330229 0.00639046518438605 1.40360095278128 0.576923076923077 21.2 21 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00220051155330229 0.00639046518438605 1.40360095278128 0.576923076923077 21.2 21 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00220051155330229 0.00639046518438605 1.40360095278128 0.576923076923077 21.2 21 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00220051155330229 0.00639046518438605 1.40360095278128 0.576923076923077 21.2 21 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00220051155330229 0.00639046518438605 1.40360095278128 0.576923076923077 21.2 21 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.3681092066363e-09 3.57673089630108e-08 1.40076539530091 0.575757575757576 21.2 21 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000602179923677254 0.00205000485979122 1.40076539530091 0.575757575757576 21.2 21 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000167910893683254 0.000638869523292169 1.39892228293868 0.575 21.2 21 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000167910893683254 0.000638869523292169 1.39892228293868 0.575 21.2 21 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000167910893683254 0.000638869523292169 1.39892228293868 0.575 21.2 21 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.47093073079232e-11 3.37602327406044e-10 1.39023332465955 0.571428571428571 21.2 21 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000496929313999626 0.00171982816384108 1.39023332465955 0.571428571428571 21.2 21 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00180681291552153 0.00537885936984755 1.39023332465955 0.571428571428571 21.2 21 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0067462921475731 0.0173284724295966 1.39023332465955 0.571428571428571 21.2 21 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0067462921475731 0.0173284724295966 1.39023332465955 0.571428571428571 21.2 21 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0264007548054733 0.0548441957491804 1.39023332465955 0.571428571428571 21.2 21 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0264007548054733 0.0548441957491804 1.39023332465955 0.571428571428571 21.2 21 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0264007548054733 0.0548441957491804 1.39023332465955 0.571428571428571 21.2 21 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0264007548054733 0.0548441957491804 1.39023332465955 0.571428571428571 21.2 21 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.37279380247394e-09 1.62236266596755e-08 1.38385610757396 0.568807339449541 21.2 21 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000114962297110784 0.000455686208324918 1.38233427167853 0.568181818181818 21.2 21 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000114962297110784 0.000455686208324918 1.38233427167853 0.568181818181818 21.2 21 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.14492958522951e-09 1.3925083758817e-08 1.38083985624969 0.567567567567568 21.2 21 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000409549831366594 0.00146798340059109 1.38083985624969 0.567567567567568 21.2 21 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00148169806769647 0.00443885547438333 1.37864804695406 0.566666666666667 21.2 21 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.40218930319291e-21 2.13644711152719e-19 1.37745544483732 0.566176470588235 21.2 21 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.10926218537046e-08 1.08860695847046e-07 1.37619056380441 0.565656565656566 21.2 21 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 9.49678726279819e-05 0.000381749386298357 1.37512209286978 0.565217391304348 21.2 21 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 9.49678726279819e-05 0.000381749386298357 1.37512209286978 0.565217391304348 21.2 21 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 9.49678726279819e-05 0.000381749386298357 1.37512209286978 0.565217391304348 21.2 21 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00548770537270365 0.0145419082781328 1.37512209286978 0.565217391304348 21.2 21 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00548770537270365 0.0145419082781328 1.37512209286978 0.565217391304348 21.2 21 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.87376372959736e-09 2.13309262977364e-08 1.36851092896175 0.5625 21.2 21 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0211472827556982 0.046428886759468 1.36851092896175 0.5625 21.2 21 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0211472827556982 0.046428886759468 1.36851092896175 0.5625 21.2 21 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0211472827556982 0.046428886759468 1.36851092896175 0.5625 21.2 21 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0211472827556982 0.046428886759468 1.36851092896175 0.5625 21.2 21 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0211472827556982 0.046428886759468 1.36851092896175 0.5625 21.2 21 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0211472827556982 0.046428886759468 1.36851092896175 0.5625 21.2 21 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000277372161375368 0.00101726955061121 1.36480222725725 0.560975609756098 21.2 21 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.81019296502311e-10 5.02028202706285e-09 1.36480222725725 0.560975609756098 21.2 21 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 5.3015981487246e-09 5.50669647126651e-08 1.36424765503975 0.560747663551402 21.2 21 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00446172405866723 0.0120933968294923 1.36242865816636 0.56 21.2 21 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00446172405866723 0.0120933968294923 1.36242865816636 0.56 21.2 21 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.63076950277063e-10 3.67018137494373e-09 1.36012984715708 0.559055118110236 21.2 21 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000993907011890048 0.00319984090027045 1.35956641308618 0.558823529411765 21.2 21 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000228011553657064 0.000851602206965883 1.35790231710933 0.558139534883721 21.2 21 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000228011553657064 0.000851602206965883 1.35790231710933 0.558139534883721 21.2 21 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.24356174508522e-08 1.17191282334852e-07 1.35681425435524 0.557692307692308 21.2 21 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.79649085904148e-14 2.00747249776942e-12 1.35604725929907 0.557377049180328 21.2 21 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 3.00938557624282e-06 1.68195993914715e-05 1.35547749154307 0.557142857142857 21.2 21 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.22442226902816e-12 7.03411753072682e-11 1.35330525197328 0.55625 21.2 21 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.48680446925035e-06 1.40425506339018e-05 1.3516157323079 0.555555555555556 21.2 21 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000187328503022033 0.000707078142706506 1.3516157323079 0.555555555555556 21.2 21 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0169590424348872 0.0383059006108643 1.3516157323079 0.555555555555556 21.2 21 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0169590424348872 0.0383059006108643 1.3516157323079 0.555555555555556 21.2 21 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0884713421143169 0.149874666462706 1.3516157323079 0.555555555555556 21.2 21 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0884713421143169 0.149874666462706 1.3516157323079 0.555555555555556 21.2 21 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0884713421143169 0.149874666462706 1.3516157323079 0.555555555555556 21.2 21 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0884713421143169 0.149874666462706 1.3516157323079 0.555555555555556 21.2 21 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0884713421143169 0.149874666462706 1.3516157323079 0.555555555555556 21.2 21 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0884713421143169 0.149874666462706 1.3516157323079 0.555555555555556 21.2 21 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0884713421143169 0.149874666462706 1.3516157323079 0.555555555555556 21.2 21 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0884713421143169 0.149874666462706 1.3516157323079 0.555555555555556 21.2 21 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 6.23494274417851e-12 1.58434348660108e-10 1.34987171200815 0.554838709677419 21.2 21 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 5.17132575628628e-12 1.33796300930825e-10 1.34817212534661 0.554140127388535 21.2 21 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.28798714936156e-12 1.17342417568106e-10 1.34651529558221 0.553459119496855 21.2 21 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.90273749009405e-10 4.01028684311051e-09 1.34547202443377 0.553030303030303 21.2 21 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.36429580232813e-10 1.98101319052339e-09 1.33809957498482 0.55 21.2 21 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.59211701879886e-08 4.5471900101433e-07 1.33809957498482 0.55 21.2 21 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0136172133338323 0.0313041915574206 1.33809957498482 0.55 21.2 21 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0136172133338323 0.0313041915574206 1.33809957498482 0.55 21.2 21 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0136172133338323 0.0313041915574206 1.33809957498482 0.55 21.2 21 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0136172133338323 0.0313041915574206 1.33809957498482 0.55 21.2 21 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0023962207769113 0.00693053285679835 1.33417552931038 0.548387096774194 21.2 21 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.000444848783398909 0.00157805951761407 1.33230693613207 0.547619047619048 21.2 21 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000444848783398909 0.00157805951761407 1.33230693613207 0.547619047619048 21.2 21 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.12329302160887e-15 5.51188265430835e-14 1.33100813818303 0.547085201793722 21.2 21 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 6.47330664318884e-07 4.24493795081001e-06 1.32961268550289 0.546511627906977 21.2 21 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.36483748334302e-11 9.13406432176046e-10 1.32849598951842 0.546052631578947 21.2 21 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.35971178813225e-05 6.40685388911323e-05 1.32704090081139 0.545454545454545 21.2 21 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000363670661512602 0.00131680242069321 1.32704090081139 0.545454545454545 21.2 21 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00194808652816021 0.00577526485327495 1.32704090081139 0.545454545454545 21.2 21 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00194808652816021 0.00577526485327495 1.32704090081139 0.545454545454545 21.2 21 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0687463247640938 0.123361942168103 1.32704090081139 0.545454545454545 21.2 21 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0687463247640938 0.123361942168103 1.32704090081139 0.545454545454545 21.2 21 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0687463247640938 0.123361942168103 1.32704090081139 0.545454545454545 21.2 21 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0687463247640938 0.123361942168103 1.32704090081139 0.545454545454545 21.2 21 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0687463247640938 0.123361942168103 1.32704090081139 0.545454545454545 21.2 21 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0687463247640938 0.123361942168103 1.32704090081139 0.545454545454545 21.2 21 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.37854542401045e-55 1.96167013836687e-52 1.31553187339108 0.540723981900452 21.2 21 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 4.17850129391469e-06 2.1780246671211e-05 1.3100275559292 0.538461538461538 21.2 21 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00104811608462169 0.00334304107928553 1.3100275559292 0.538461538461538 21.2 21 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00709980531492631 0.0182036449786309 1.3100275559292 0.538461538461538 21.2 21 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0538158187038208 0.0997134244993972 1.3100275559292 0.538461538461538 21.2 21 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0538158187038208 0.0997134244993972 1.3100275559292 0.538461538461538 21.2 21 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0538158187038208 0.0997134244993972 1.3100275559292 0.538461538461538 21.2 21 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0538158187038208 0.0997134244993972 1.3100275559292 0.538461538461538 21.2 21 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0538158187038208 0.0997134244993972 1.3100275559292 0.538461538461538 21.2 21 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 7.18871117948727e-11 1.32851116992343e-09 1.30884308255132 0.537974683544304 21.2 21 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.73524919008922e-05 8.06947580881357e-05 1.30460301118415 0.536231884057971 21.2 21 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.18058965641033e-09 1.42371108565415e-08 1.30334374186833 0.535714285714286 21.2 21 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00572665198787332 0.0150074139571708 1.30334374186833 0.535714285714286 21.2 21 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.42218297347984e-05 6.67909693485746e-05 1.30211994492761 0.535211267605634 21.2 21 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000694211597602033 0.00230485732737669 1.30132305389644 0.534883720930233 21.2 21 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.63923516295048e-13 6.30440982940143e-12 1.29755110301558 0.533333333333333 21.2 21 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00462348123272057 0.0124842766492626 1.29755110301558 0.533333333333333 21.2 21 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0423679477276899 0.0806010556370357 1.29755110301558 0.533333333333333 21.2 21 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0423679477276899 0.0806010556370357 1.29755110301558 0.533333333333333 21.2 21 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0423679477276899 0.0806010556370357 1.29755110301558 0.533333333333333 21.2 21 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.19367130880085e-09 2.45794824600284e-08 1.29521737801016 0.532374100719424 21.2 21 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 5.25801066141369e-06 2.70113688490674e-05 1.2915439219831 0.530864197530864 21.2 21 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.5315842646074e-06 1.85440753082522e-05 1.28801028608165 0.529411764705882 21.2 21 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.5315842646074e-06 1.85440753082522e-05 1.28801028608165 0.529411764705882 21.2 21 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 3.24185457796625e-05 0.000143712120387725 1.28801028608165 0.529411764705882 21.2 21 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00302153848396415 0.00854801046258644 1.28801028608165 0.529411764705882 21.2 21 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00302153848396415 0.00854801046258644 1.28801028608165 0.529411764705882 21.2 21 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0335061860194381 0.0669653127888488 1.28801028608165 0.529411764705882 21.2 21 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0335061860194381 0.0669653127888488 1.28801028608165 0.529411764705882 21.2 21 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0335061860194381 0.0669653127888488 1.28801028608165 0.529411764705882 21.2 21 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.95102471172543e-08 2.51455578729658e-07 1.28568325756117 0.528455284552846 21.2 21 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00244548288975145 0.00704437682614639 1.2840349456925 0.527777777777778 21.2 21 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00244548288975145 0.00704437682614639 1.2840349456925 0.527777777777778 21.2 21 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.99061460169283e-08 1.78153747057164e-07 1.28350281351443 0.52755905511811 21.2 21 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 3.15229785216502e-10 4.31319215733733e-09 1.27579338634916 0.524390243902439 21.2 21 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 7.94934370556145e-06 3.92774864340762e-05 1.27579338634916 0.524390243902439 21.2 21 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 5.72624316042178e-30 9.05382668586688e-28 1.27568226420071 0.524344569288389 21.2 21 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.99174091623957e-11 4.45813734822731e-10 1.27500008117173 0.524064171122995 21.2 21 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 4.83253705972317e-07 3.29028719425171e-06 1.27438054760459 0.523809523809524 21.2 21 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.98384671612052e-05 0.000365257539343986 1.27438054760459 0.523809523809524 21.2 21 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.0013017362956535 0.003932846600244 1.27438054760459 0.523809523809524 21.2 21 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0013017362956535 0.003932846600244 1.27438054760459 0.523809523809524 21.2 21 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0211752266387173 0.046428886759468 1.27438054760459 0.523809523809524 21.2 21 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0211752266387173 0.046428886759468 1.27438054760459 0.523809523809524 21.2 21 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 7.33150175811433e-05 0.000302397884110049 1.27259819718836 0.523076923076923 21.2 21 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0169032980801903 0.0383015814778835 1.26934347034133 0.521739130434783 21.2 21 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0169032980801903 0.0383015814778835 1.26934347034133 0.521739130434783 21.2 21 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.00506528662367e-11 4.45813734822731e-10 1.26713974903866 0.520833333333333 21.2 21 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000696478320992253 0.00230485732737669 1.26713974903866 0.520833333333333 21.2 21 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000696478320992253 0.00230485732737669 1.26713974903866 0.520833333333333 21.2 21 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.31186806582536e-06 8.4089561156283e-06 1.26511232544019 0.52 21.2 21 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0135232618543838 0.0312904091362409 1.26511232544019 0.52 21.2 21 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0135232618543838 0.0312904091362409 1.26511232544019 0.52 21.2 21 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0135232618543838 0.0312904091362409 1.26511232544019 0.52 21.2 21 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0135232618543838 0.0312904091362409 1.26511232544019 0.52 21.2 21 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0108400314396479 0.0255386833420844 1.26150801682071 0.518518518518518 21.2 21 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0108400314396479 0.0255386833420844 1.26150801682071 0.518518518518518 21.2 21 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.18591328527416e-18 3.20850200215006e-16 1.26123161278547 0.51840490797546 21.2 21 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.18625325676351e-05 5.68363092381977e-05 1.26042238169435 0.518072289156627 21.2 21 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 6.48123237325621e-06 3.21351695719289e-05 1.25745823185499 0.51685393258427 21.2 21 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 7.25085084445398e-05 0.000300815182264082 1.2512099921936 0.514285714285714 21.2 21 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00296225506298016 0.00841375040842468 1.24764529136114 0.512820512820513 21.2 21 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.16626018036488e-05 5.6067170157406e-05 1.24410084451068 0.511363636363636 21.2 21 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 4.34800752769194e-08 3.57642468896279e-07 1.24270856538813 0.510791366906475 21.2 21 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.08733387049807e-19 2.44070894317709e-17 1.24247456889694 0.510695187165775 21.2 21 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 3.82203099227307e-05 0.000167346156984756 1.23147211165831 0.506172839506173 21.2 21 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.22545057076525e-13 4.84393378388599e-12 1.22084569033732 0.501805054151625 21.2 21 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.16258755501126e-08 1.92335130673814e-07 1.21645415907711 0.5 21.2 21 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.2229494122003e-08 2.72991488902442e-07 1.21645415907711 0.5 21.2 21 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 3.23175177889686e-06 1.71596372439188e-05 1.21645415907711 0.5 21.2 21 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000101548954184506 0.000405910566866718 1.21645415907711 0.5 21.2 21 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000187851588514777 0.000707176747239492 1.21645415907711 0.5 21.2 21 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000428593593665271 0.00153238362760221 1.21645415907711 0.5 21.2 21 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000648952288296386 0.00219348956352911 1.21645415907711 0.5 21.2 21 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000648952288296386 0.00219348956352911 1.21645415907711 0.5 21.2 21 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000648952288296386 0.00219348956352911 1.21645415907711 0.5 21.2 21 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00121357162667853 0.00377055114577193 1.21645415907711 0.5 21.2 21 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00348856821179428 0.00957619925376164 1.21645415907711 0.5 21.2 21 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0053531311253997 0.0142383282083061 1.21645415907711 0.5 21.2 21 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0082502778027975 0.0206329443117414 1.21645415907711 0.5 21.2 21 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0082502778027975 0.0206329443117414 1.21645415907711 0.5 21.2 21 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0082502778027975 0.0206329443117414 1.21645415907711 0.5 21.2 21 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0102623301871428 0.0242579665387112 1.21645415907711 0.5 21.2 21 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0199467183938413 0.0443502816788066 1.21645415907711 0.5 21.2 21 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0199467183938413 0.0443502816788066 1.21645415907711 0.5 21.2 21 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0314031166098461 0.0632257254900805 1.21645415907711 0.5 21.2 21 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0314031166098461 0.0632257254900805 1.21645415907711 0.5 21.2 21 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0395741504376434 0.0771424877709131 1.21645415907711 0.5 21.2 21 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0395741504376434 0.0771424877709131 1.21645415907711 0.5 21.2 21 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0395741504376434 0.0771424877709131 1.21645415907711 0.5 21.2 21 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0395741504376434 0.0771424877709131 1.21645415907711 0.5 21.2 21 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0500533296039891 0.0940896803520165 1.21645415907711 0.5 21.2 21 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0500533296039891 0.0940896803520165 1.21645415907711 0.5 21.2 21 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.0500533296039891 0.0940896803520165 1.21645415907711 0.5 21.2 21 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0500533296039891 0.0940896803520165 1.21645415907711 0.5 21.2 21 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0635886126996815 0.115284702113342 1.21645415907711 0.5 21.2 21 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0635886126996815 0.115284702113342 1.21645415907711 0.5 21.2 21 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0635886126996815 0.115284702113342 1.21645415907711 0.5 21.2 21 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0635886126996815 0.115284702113342 1.21645415907711 0.5 21.2 21 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0635886126996815 0.115284702113342 1.21645415907711 0.5 21.2 21 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0812308826021684 0.142004356195191 1.21645415907711 0.5 21.2 21 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0812308826021684 0.142004356195191 1.21645415907711 0.5 21.2 21 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0812308826021684 0.142004356195191 1.21645415907711 0.5 21.2 21 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0812308826021684 0.142004356195191 1.21645415907711 0.5 21.2 21 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0812308826021684 0.142004356195191 1.21645415907711 0.5 21.2 21 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0812308826021684 0.142004356195191 1.21645415907711 0.5 21.2 21 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.135713873075861 0.221468854801548 1.21645415907711 0.5 21.2 21 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.135713873075861 0.221468854801548 1.21645415907711 0.5 21.2 21 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.135713873075861 0.221468854801548 1.21645415907711 0.5 21.2 21 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0249953339597694 0.0526159174922364 1.21645415907711 0.5 21.2 21 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0249953339597694 0.0526159174922364 1.21645415907711 0.5 21.2 21 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.104503621481324 0.174951356903439 1.21645415907711 0.5 21.2 21 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.104503621481324 0.174951356903439 1.21645415907711 0.5 21.2 21 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.104503621481324 0.174951356903439 1.21645415907711 0.5 21.2 21 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.104503621481324 0.174951356903439 1.21645415907711 0.5 21.2 21 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.29120950321296e-34 6.52078224614409e-32 1.20866636036343 0.496798975672215 21.2 21 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 6.16679281361025e-07 4.06266026563305e-06 1.20716824946583 0.49618320610687 21.2 21 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 6.16679281361025e-07 4.06266026563305e-06 1.20716824946583 0.49618320610687 21.2 21 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.68160153494712e-06 1.06351954854656e-05 1.20640081891945 0.495867768595041 21.2 21 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.68160153494712e-06 1.06351954854656e-05 1.20640081891945 0.495867768595041 21.2 21 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 6.38771202825467e-05 0.000268133162719953 1.2021429336762 0.494117647058824 21.2 21 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 6.38771202825467e-05 0.000268133162719953 1.2021429336762 0.494117647058824 21.2 21 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 6.38771202825467e-05 0.000268133162719953 1.2021429336762 0.494117647058824 21.2 21 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 6.38771202825467e-05 0.000268133162719953 1.2021429336762 0.494117647058824 21.2 21 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 6.38771202825467e-05 0.000268133162719953 1.2021429336762 0.494117647058824 21.2 21 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 9.6032691743706e-05 0.000384942310848715 1.20143620649591 0.493827160493827 21.2 21 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00140175712093175 0.00421712554563611 1.19433681073025 0.490909090909091 21.2 21 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00263078057669378 0.00756282981946515 1.1916285639939 0.489795918367347 21.2 21 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 4.88755598829638e-05 0.000212690892090084 1.190009503445 0.489130434782609 21.2 21 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 3.85177980186346e-08 3.20531149593667e-07 1.18816452747067 0.488372093023256 21.2 21 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00615181549721397 0.0160624467019 1.18678454544108 0.48780487804878 21.2 21 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00615181549721397 0.0160624467019 1.18678454544108 0.48780487804878 21.2 21 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0117510611480886 0.0275936633889936 1.18169832596062 0.485714285714286 21.2 21 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.17053237877035e-25 1.38805631249184e-23 1.18050916837343 0.485225505443235 21.2 21 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 7.66916339575254e-11 1.36415243901948e-09 1.17783656672546 0.484126984126984 21.2 21 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 7.66916339575254e-11 1.36415243901948e-09 1.17783656672546 0.484126984126984 21.2 21 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 7.66916339575254e-11 1.36415243901948e-09 1.17783656672546 0.484126984126984 21.2 21 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0182079416144854 0.0408750602506089 1.17721370233269 0.483870967741935 21.2 21 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000230288602503131 0.000853727464901612 1.17140030133351 0.481481481481481 21.2 21 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0284029277084494 0.0575745956255321 1.17140030133351 0.481481481481481 21.2 21 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0355849389801254 0.0701348589594438 1.16779599271403 0.48 21.2 21 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00453910451618648 0.0122797447272497 1.16576856911556 0.479166666666667 21.2 21 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00560645812015846 0.0148014655009007 1.16356484781289 0.478260869565217 21.2 21 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00560645812015846 0.0148014655009007 1.16356484781289 0.478260869565217 21.2 21 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0446946169286973 0.0846876696265463 1.16356484781289 0.478260869565217 21.2 21 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.85629873863009e-05 0.000168328622854927 1.15961050678379 0.476635514018692 21.2 21 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.29965238382696e-05 6.18530214777846e-05 1.15662854469627 0.475409836065574 21.2 21 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00178826287902445 0.00533479680681718 1.15662854469627 0.475409836065574 21.2 21 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.020275571495471 0.04501113609681 1.14489803207257 0.470588235294118 21.2 21 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0903285475265648 0.152295643519315 1.14489803207257 0.470588235294118 21.2 21 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0903285475265648 0.152295643519315 1.14489803207257 0.470588235294118 21.2 21 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0903285475265648 0.152295643519315 1.14489803207257 0.470588235294118 21.2 21 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0903285475265648 0.152295643519315 1.14489803207257 0.470588235294118 21.2 21 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.24518671304609e-33 2.95316782110764e-31 1.14217617739172 0.469469469469469 21.2 21 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 5.41683945522258e-06 2.70424111467397e-05 1.13989410710722 0.468531468531469 21.2 21 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00947942601743655 0.023224354025924 1.13535721513864 0.466666666666667 21.2 21 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0314129219406092 0.0632257254900805 1.13535721513864 0.466666666666667 21.2 21 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.115235950617337 0.190232897596834 1.13535721513864 0.466666666666667 21.2 21 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.115235950617337 0.190232897596834 1.13535721513864 0.466666666666667 21.2 21 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.00367356535047622 0.0100143361948806 1.13256076879593 0.46551724137931 21.2 21 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.00367356535047622 0.0100143361948806 1.13256076879593 0.46551724137931 21.2 21 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0117072758399197 0.0275362868102575 1.13158526425778 0.465116279069767 21.2 21 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0391925089498728 0.076819476908635 1.12956457628589 0.464285714285714 21.2 21 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0391925089498728 0.076819476908635 1.12956457628589 0.464285714285714 21.2 21 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0178971036628714 0.0402968014434589 1.12288076222502 0.461538461538462 21.2 21 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0178971036628714 0.0402968014434589 1.12288076222502 0.461538461538462 21.2 21 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.147950309576326 0.2403348065378 1.12288076222502 0.461538461538462 21.2 21 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.147950309576326 0.2403348065378 1.12288076222502 0.461538461538462 21.2 21 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.147950309576326 0.2403348065378 1.12288076222502 0.461538461538462 21.2 21 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.147950309576326 0.2403348065378 1.12288076222502 0.461538461538462 21.2 21 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0613632409793284 0.113255372131756 1.11508297915402 0.458333333333333 21.2 21 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0274541065248455 0.0561918580538144 1.11218665972764 0.457142857142857 21.2 21 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0274541065248455 0.0561918580538144 1.11218665972764 0.457142857142857 21.2 21 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 5.97263053168863e-07 3.97152020868828e-06 1.11148095753238 0.456852791878173 21.2 21 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00140639760516661 0.00422215989905502 1.10866708169053 0.455696202531646 21.2 21 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0340539131177669 0.0675853812644105 1.10586741734283 0.454545454545455 21.2 21 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0340539131177669 0.0675853812644105 1.10586741734283 0.454545454545455 21.2 21 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0340539131177669 0.0675853812644105 1.10586741734283 0.454545454545455 21.2 21 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0340539131177669 0.0675853812644105 1.10586741734283 0.454545454545455 21.2 21 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0340539131177669 0.0675853812644105 1.10586741734283 0.454545454545455 21.2 21 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.191520163335666 0.300809263164076 1.10586741734283 0.454545454545455 21.2 21 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.191520163335666 0.300809263164076 1.10586741734283 0.454545454545455 21.2 21 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.191520163335666 0.300809263164076 1.10586741734283 0.454545454545455 21.2 21 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.191520163335666 0.300809263164076 1.10586741734283 0.454545454545455 21.2 21 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.191520163335666 0.300809263164076 1.10586741734283 0.454545454545455 21.2 21 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 3.01983646737961e-05 0.000134288352908787 1.10429881107709 0.453900709219858 21.2 21 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00908239272589346 0.0224379250849764 1.10169433274908 0.452830188679245 21.2 21 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.34067981421957e-05 6.33816403865263e-05 1.10023242413344 0.452229299363057 21.2 21 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0422876116209466 0.0806010556370357 1.09873278884384 0.451612903225806 21.2 21 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0422876116209466 0.0806010556370357 1.09873278884384 0.451612903225806 21.2 21 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.84591280740484e-14 1.30636578223777e-12 1.097775704533 0.451219512195122 21.2 21 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0238553094366732 0.0512781047256585 1.0948087431694 0.45 21.2 21 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0970124451881373 0.163178143620236 1.0948087431694 0.45 21.2 21 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.052576749563911 0.0980559824763373 1.09061407365534 0.448275862068966 21.2 21 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0294418387615654 0.0595956423295982 1.08840635285847 0.447368421052632 21.2 21 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.00972832156593306 0.0233841243045992 1.08611978489028 0.446428571428571 21.2 21 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0363592795092554 0.0715619014407614 1.08129258584632 0.444444444444444 21.2 21 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.122548721864625 0.202070488080373 1.08129258584632 0.444444444444444 21.2 21 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.59051344088793e-38 5.65825156595882e-36 1.07745326420516 0.44286636539703 21.2 21 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0145771999980816 0.0334031491099357 1.07609406379898 0.442307692307692 21.2 21 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.20326888196187e-05 5.74581080211992e-05 1.0710085531005 0.440217391304348 21.2 21 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0816176211215593 0.142505367921447 1.07047965998786 0.44 21.2 21 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.55787035846415e-05 0.000274192264681188 1.0673404234483 0.438709677419355 21.2 21 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0218486269903874 0.0470356977417871 1.06439738919247 0.4375 21.2 21 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0267499241132072 0.0554885452085916 1.05778622528444 0.434782608695652 21.2 21 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.15072221664985e-05 9.93661595549588e-05 1.05172599170208 0.432291666666667 21.2 21 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0279680737218178 0.0567739927334475 1.04267499349467 0.428571428571429 21.2 21 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0279680737218178 0.0567739927334475 1.04267499349467 0.428571428571429 21.2 21 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.197989879806944 0.309944553317142 1.04267499349467 0.428571428571429 21.2 21 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.197989879806944 0.309944553317142 1.04267499349467 0.428571428571429 21.2 21 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.197989879806944 0.309944553317142 1.04267499349467 0.428571428571429 21.2 21 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.12868733934414e-10 5.39002026044653e-09 1.04189571472524 0.428251121076233 21.2 21 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000216423867519384 0.000812588821847185 1.02988143529228 0.423312883435583 21.2 21 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.105545182704375 0.176487420667833 1.02930736537294 0.423076923076923 21.2 21 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.000258794590871299 0.000954053634222433 1.02756376170489 0.422360248447205 21.2 21 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0600818844207797 0.111034443546454 1.02438244974915 0.421052631578947 21.2 21 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.159918546820414 0.255689991152191 1.02438244974915 0.421052631578947 21.2 21 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.000320215124666128 0.00116837467282026 1.02122077552152 0.419753086419753 21.2 21 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0878804162880477 0.149874666462706 1.020251875355 0.419354838709677 21.2 21 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0878804162880477 0.149874666462706 1.020251875355 0.419354838709677 21.2 21 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.32695766213125e-11 9.13406432176046e-10 1.01832764980536 0.418563922942207 21.2 21 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0300039877027439 0.0606472649161997 1.0173980239554 0.418181818181818 21.2 21 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.32865476234359e-05 6.30225242271641e-05 1.01615447826522 0.417670682730924 21.2 21 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0428689451280807 0.0814452722526821 1.01371179923092 0.416666666666667 21.2 21 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.0439580541297724 0.0834030813688882 1.0017857780635 0.411764705882353 21.2 21 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.200960390694222 0.313518981845735 1.0017857780635 0.411764705882353 21.2 21 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.16250675660824 0.25924564423041 0.995280675608544 0.409090909090909 21.2 21 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000988919226791789 0.00319100240300389 0.994585161509587 0.408805031446541 21.2 21 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000988919226791789 0.00319100240300389 0.994585161509587 0.408805031446541 21.2 21 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0194648884907833 0.0434146337341452 0.992370498194484 0.407894736842105 21.2 21 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 9.10252961353269e-05 0.000369028479773704 0.991958327144424 0.407725321888412 21.2 21 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0448779821482432 0.0849220327087102 0.991184870359127 0.407407407407407 21.2 21 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.133105060086352 0.218716513282771 0.991184870359127 0.407407407407407 21.2 21 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.133105060086352 0.218716513282771 0.991184870359127 0.407407407407407 21.2 21 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0379852899862891 0.074658933218908 0.989657620944089 0.406779661016949 21.2 21 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.109992077306689 0.183707424891337 0.988369004250152 0.40625 21.2 21 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.0048988879283541 0.013079019741178 0.981011418610573 0.403225806451613 21.2 21 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0774564244095499 0.136749989993535 0.973163327261688 0.4 21.2 21 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.134418246830884 0.220111812704658 0.973163327261688 0.4 21.2 21 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.134418246830884 0.220111812704658 0.973163327261688 0.4 21.2 21 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.134418246830884 0.220111812704658 0.973163327261688 0.4 21.2 21 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.201855947908599 0.313518981845735 0.973163327261688 0.4 21.2 21 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.25315916593335 0.375647020983479 0.973163327261688 0.4 21.2 21 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.25315916593335 0.375647020983479 0.973163327261688 0.4 21.2 21 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.25315916593335 0.375647020983479 0.973163327261688 0.4 21.2 21 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00237428467349664 0.00688107350384056 0.973163327261688 0.4 21.2 21 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00821475888429919 0.0206329443117414 0.965120655135558 0.396694214876033 21.2 21 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0781650479266676 0.137830065922736 0.963026209269379 0.395833333333333 21.2 21 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.111970182911353 0.186573267310135 0.960358546639824 0.394736842105263 21.2 21 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00530622748603061 0.0141400032071565 0.959456801525608 0.394366197183099 21.2 21 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0790614889048203 0.139238240979653 0.939017245603383 0.385964912280702 21.2 21 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0101359551278732 0.0240598068955098 0.938407494145199 0.385714285714286 21.2 21 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.319752665159044 0.459140305268738 0.935733968520854 0.384615384615385 21.2 21 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.319752665159044 0.459140305268738 0.935733968520854 0.384615384615385 21.2 21 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.319752665159044 0.459140305268738 0.935733968520854 0.384615384615385 21.2 21 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0348417765189219 0.068860899981147 0.931752121846297 0.382978723404255 21.2 21 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0137944791925034 0.031660554662794 0.930229651058966 0.382352941176471 21.2 21 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.247584872480652 0.370466113080934 0.926822216439703 0.380952380952381 21.2 21 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0348147216773532 0.068860899981147 0.924505160898604 0.38 21.2 21 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0160558328054198 0.0364975240928312 0.923439653605981 0.37956204379562 21.2 21 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0160558328054198 0.0364975240928312 0.923439653605981 0.37956204379562 21.2 21 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.198336926941062 0.310146645095748 0.92282729309298 0.379310344827586 21.2 21 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.161824511687184 0.258447003513876 0.920559904166462 0.378378378378378 21.2 21 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0476035814778422 0.0899600218366128 0.915610657369868 0.376344086021505 21.2 21 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0557932378511163 0.10324288356585 0.912340619307833 0.375 21.2 21 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0925628430607748 0.155878018550867 0.912340619307833 0.375 21.2 21 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.311811004094718 0.449551224748515 0.912340619307833 0.375 21.2 21 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.311811004094718 0.449551224748515 0.912340619307833 0.375 21.2 21 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.311811004094718 0.449551224748515 0.912340619307833 0.375 21.2 21 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.239634207153777 0.359089632027381 0.901077154871933 0.37037037037037 21.2 21 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.239634207153777 0.359089632027381 0.901077154871933 0.37037037037037 21.2 21 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.303907162911038 0.44038685623463 0.896334643530502 0.368421052631579 21.2 21 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.000134462486283783 0.000530028027650478 0.894523866472865 0.367676767676768 21.2 21 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.125809547273542 0.207207159456309 0.888204624088049 0.365079365079365 21.2 21 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.230977545493738 0.351906902823971 0.884693933874262 0.363636363636364 21.2 21 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.29620093869346 0.429657426871349 0.884693933874262 0.363636363636364 21.2 21 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.29620093869346 0.429657426871349 0.884693933874262 0.363636363636364 21.2 21 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.288752751224792 0.423408920185589 0.875846994535519 0.36 21.2 21 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.176320216705298 0.280967153831622 0.872174680093022 0.358490566037736 21.2 21 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.281580933974815 0.415222454970115 0.868895827912221 0.357142857142857 21.2 21 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.281580933974815 0.415222454970115 0.868895827912221 0.357142857142857 21.2 21 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.387398657021321 0.529048261939866 0.868895827912221 0.357142857142857 21.2 21 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.387398657021321 0.529048261939866 0.868895827912221 0.357142857142857 21.2 21 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.387398657021321 0.529048261939866 0.868895827912221 0.357142857142857 21.2 21 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.111137919459286 0.185403586624342 0.865034068677056 0.355555555555556 21.2 21 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.268056144321116 0.396923926502548 0.85867352405443 0.352941176470588 21.2 21 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.372274975040443 0.510353843432129 0.85867352405443 0.352941176470588 21.2 21 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.35885781714312 0.492434593823201 0.851517911353977 0.35 21.2 21 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.346737250134572 0.477182888724851 0.846228980227555 0.347826086956522 21.2 21 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.346737250134572 0.477182888724851 0.846228980227555 0.347826086956522 21.2 21 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.228032009394465 0.347791585603776 0.840459237180549 0.345454545454545 21.2 21 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.228032009394465 0.347791585603776 0.840459237180549 0.345454545454545 21.2 21 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0352288172566629 0.0695292745578797 0.839591890186554 0.345098039215686 21.2 21 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.325393569255737 0.459534418274643 0.8389339028118 0.344827586206897 21.2 21 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.184781186273007 0.292159586740543 0.830051073252616 0.341176470588235 21.2 21 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.184781186273007 0.292159586740543 0.830051073252616 0.341176470588235 21.2 21 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.268936639124847 0.397813760368666 0.827188828172435 0.34 21.2 21 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.358282863380343 0.492120187828406 0.81096943938474 0.333333333333333 21.2 21 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.383650027983586 0.525441761136326 0.81096943938474 0.333333333333333 21.2 21 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.432983099858682 0.577446064759986 0.81096943938474 0.333333333333333 21.2 21 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.432983099858682 0.577446064759986 0.81096943938474 0.333333333333333 21.2 21 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.432983099858682 0.577446064759986 0.81096943938474 0.333333333333333 21.2 21 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.432983099858682 0.577446064759986 0.81096943938474 0.333333333333333 21.2 21 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.454518402565307 0.595013511361942 0.81096943938474 0.333333333333333 21.2 21 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.454518402565307 0.595013511361942 0.81096943938474 0.333333333333333 21.2 21 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.398224350376636 0.542790469909917 0.81096943938474 0.333333333333333 21.2 21 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.188197381226811 0.297230714190623 0.804583853247852 0.330708661417323 21.2 21 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.231739140556986 0.352689622473359 0.802608929700361 0.329896907216495 21.2 21 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.2653336637953 0.393301878729908 0.800704003443161 0.329113924050633 21.2 21 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.307608768791493 0.444844794705584 0.79767485841122 0.327868852459016 21.2 21 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.307608768791493 0.444844794705584 0.79767485841122 0.327868852459016 21.2 21 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.388039750154951 0.52941568980872 0.789051346428396 0.324324324324324 21.2 21 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.449740397036327 0.595013511361942 0.77853066180935 0.32 21.2 21 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.349401074241661 0.480384278884912 0.775709898541925 0.318840579710145 21.2 21 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.469697853172104 0.61319270189349 0.774107192139979 0.318181818181818 21.2 21 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.492556609219133 0.629036566914443 0.768286837311859 0.315789473684211 21.2 21 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.492556609219133 0.629036566914443 0.768286837311859 0.315789473684211 21.2 21 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.461533597295669 0.603641828080641 0.760283849423194 0.3125 21.2 21 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.51938540187012 0.652326060777741 0.760283849423194 0.3125 21.2 21 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.51938540187012 0.652326060777741 0.760283849423194 0.3125 21.2 21 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.277657391012813 0.410287089731291 0.753724537781111 0.309803921568627 21.2 21 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.462941106397487 0.604926716624081 0.74476785249619 0.306122448979592 21.2 21 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.477967457921564 0.623416766839951 0.74045035769911 0.304347826086957 21.2 21 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.445234021235144 0.593228475859185 0.739111387793687 0.30379746835443 21.2 21 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.506425220737114 0.639434861676055 0.737244944895218 0.303030303030303 21.2 21 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.526921502064135 0.661207493330921 0.729872495446266 0.3 21.2 21 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.549628326740226 0.689093488062856 0.720861723897547 0.296296296296296 21.2 21 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.318927213186471 0.459140305268738 0.720378219082737 0.29609756097561 21.2 21 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.551083678577937 0.689611740883637 0.71207072726465 0.292682926829268 21.2 21 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.604000812362652 0.740942375855219 0.695116662329777 0.285714285714286 21.2 21 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.611089822956435 0.748348380436323 0.688095281902204 0.282828282828283 21.2 21 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.610310086472598 0.74803725499613 0.686204910248626 0.282051282051282 21.2 21 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.62381536482804 0.759357796535758 0.681214329083182 0.28 21.2 21 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.626615543587167 0.762114460277383 0.678951158554666 0.27906976744186 21.2 21 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.641540408254485 0.77146437329066 0.672932088000103 0.276595744680851 21.2 21 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.885827541147193 0.989429035362995 0.61809022136891 0.254054054054054 21.2 21 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.742380934627945 0.861583283440234 0.608227079538555 0.25 21.2 21 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.880339265611484 0.984071307906632 0.589019908605758 0.242105263157895 21.2 21 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.863900258301468 0.971034808501571 0.582527343783405 0.23943661971831 21.2 21 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.776874909713966 0.892966879259268 0.579263885274814 0.238095238095238 21.2 21 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.812989725492224 0.927734065256964 0.561440381112512 0.230769230769231 21.2 21 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.841688263091743 0.94906687668744 0.549366394421921 0.225806451612903 21.2 21 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.984742044170744 1 0.534053045448487 0.219512195121951 21.2 21 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.865621652951424 0.972201745974645 0.532198694596236 0.21875 21.2 21 2 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.844116603763735 0.951051407090891 0.528893112642222 0.217391304347826 21.2 21 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.974338389837561 1 0.51465368268647 0.211538461538462 21.2 21 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.995486527003719 1 0.510125937677498 0.209677419354839 21.2 21 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.893655761963411 0.997389920999163 0.486581663630844 0.2 21.2 21 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.920130367311525 1 0.486581663630844 0.2 21.2 21 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.968442734712845 1 0.459039305312117 0.188679245283019 21.2 21 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.954314078249499 1 0.448167321765251 0.184210526315789 21.2 21 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.96578178326176 1 0.417069997397866 0.171428571428571 21.2 21 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.962480141745522 1 0.40548471969237 0.166666666666667 21.2 21 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99999999996388 1 0.36995255353376 0.152061855670103 21.2 21 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.984808279760922 1 0.357780635022679 0.147058823529412 21.2 21 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999999970241273 1 0.336346772095053 0.138248847926267 21.2 21 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.304368882791754 0.125104953820319 21.2 21 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999999997212 1 0.295424581490155 0.121428571428571 21.2 21 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999993705434336 1 0.292850075333378 0.12037037037037 21.2 21 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999402383376508 1 0.258820033846194 0.106382978723404 21.2 21 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999540618113169 1 0.253427949807731 0.104166666666667 21.2 21 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999997227364861 1 0.243290831815422 0.1 21.2 21 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999999981938 1 0.221173483468565 0.0909090909090909 21.2 21 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.21997362731955 0.0904159132007233 21.2 21 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.941890957576e-06 2.94810622016242e-05 7.34949544671425 1 22.1 22 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 2.52051966174081e-06 2.58035933716343e-05 6.43080851587497 0.875 22.1 22 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 3.15397966247052e-08 7.32760925366668e-07 6.12457953892854 0.833333333333333 22.1 22 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 7.87020078177552e-07 1.04666315069781e-05 5.51212158503569 0.75 22.1 22 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 4.95911568482458e-06 4.80055892483359e-05 5.34508759761036 0.727272727272727 22.1 22 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 3.80291808750144e-07 5.15385946525195e-06 5.24963960479589 0.714285714285714 22.1 22 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 3.03290777268222e-05 0.00025537442369981 5.14464681269997 0.7 22.1 22 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 2.28364496184295e-06 2.37199035087775e-05 5.08811223234064 0.692307692307692 22.1 22 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 1.33033068981187e-05 0.000119047341777956 4.89966363114283 0.666666666666667 22.1 22 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 5.70968063741001e-06 5.45293660874795e-05 4.7246756443163 0.642857142857143 22.1 22 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 8.16914610809035e-08 1.35562765806586e-06 4.54968765748977 0.619047619047619 22.1 22 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 1.2748057201925e-05 0.000114813198723666 4.40969726802855 0.6 22.1 22 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00040146404499612 0.00275982287936946 4.40969726802855 0.6 22.1 22 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 1.77659096782597e-07 2.57968259920036e-06 4.34288367305842 0.590909090909091 22.1 22 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.39474320000595e-08 1.26779753898897e-06 4.28720567724998 0.583333333333333 22.1 22 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 2.15395316282315e-06 2.27042618570173e-05 4.25497104809772 0.578947368421053 22.1 22 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 6.45682131411595e-05 0.000522048677840171 4.19971168383672 0.571428571428571 22.1 22 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000793549085431081 0.00513281976622013 4.00881569820777 0.545454545454545 22.1 22 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000793549085431081 0.00513281976622013 4.00881569820777 0.545454545454545 22.1 22 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 2.8792873003843e-07 4.01688806710477e-06 3.95742062515383 0.538461538461538 22.1 22 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.81333684119834e-08 8.89529652600681e-07 3.91973090491427 0.533333333333333 22.1 22 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000123791248500284 0.000952188900626511 3.91973090491427 0.533333333333333 22.1 22 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000123791248500284 0.000952188900626511 3.91973090491427 0.533333333333333 22.1 22 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.30861272380125e-06 1.69286900542653e-05 3.82173763229141 0.52 22.1 22 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 9.4600605973675e-07 1.23501525046366e-05 3.67474772335713 0.5 22.1 22 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.42371227952359e-05 0.000124290955445525 3.67474772335713 0.5 22.1 22 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00142637917339876 0.00842214756741261 3.67474772335713 0.5 22.1 22 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00142637917339876 0.00842214756741261 3.67474772335713 0.5 22.1 22 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 3.85050467148879e-07 5.16912089389486e-06 3.67474772335713 0.5 22.1 22 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.57024620043811e-07 2.36061395582957e-06 3.67474772335712 0.5 22.1 22 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 3.53784257366984e-05 0.000291002889152149 3.67474772335712 0.5 22.1 22 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000221555365195593 0.00162512002408933 3.67474772335712 0.5 22.1 22 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.00367824375453562 0.0186933602239435 3.67474772335712 0.5 22.1 22 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00367824375453562 0.0186933602239435 3.67474772335712 0.5 22.1 22 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.00367824375453562 0.0186933602239435 3.67474772335712 0.5 22.1 22 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.00367824375453562 0.0186933602239435 3.67474772335712 0.5 22.1 22 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 3.99837911600235e-06 3.95117602921621e-05 3.53864595582538 0.481481481481481 22.1 22 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 9.0292192763338e-10 4.75873297415666e-08 3.52163323488391 0.479166666666667 22.1 22 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000374573449460469 0.00260008789552316 3.45858609257141 0.470588235294118 22.1 22 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000374573449460469 0.00260008789552316 3.45858609257141 0.470588235294118 22.1 22 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000374573449460469 0.00260008789552316 3.45858609257141 0.470588235294118 22.1 22 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00094111951107948 0.00582266549680913 3.42976454179998 0.466666666666667 22.1 22 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00094111951107948 0.00582266549680913 3.42976454179998 0.466666666666667 22.1 22 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00094111951107948 0.00582266549680913 3.42976454179998 0.466666666666667 22.1 22 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 5.19938728412373e-08 9.36547861431401e-07 3.40586374359929 0.463414634146341 22.1 22 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 5.19938728412373e-08 9.36547861431401e-07 3.40586374359929 0.463414634146341 22.1 22 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00608215597878939 0.0270465873681791 3.34067974850648 0.454545454545455 22.1 22 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00608215597878939 0.0270465873681791 3.34067974850648 0.454545454545455 22.1 22 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.00608215597878939 0.0270465873681791 3.34067974850648 0.454545454545455 22.1 22 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00608215597878939 0.0270465873681791 3.34067974850648 0.454545454545455 22.1 22 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 3.33247788975966e-11 2.78948002183999e-09 3.33024012429239 0.453125 22.1 22 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 2.03641137284258e-07 2.92708422581312e-06 3.30727295102141 0.45 22.1 22 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.10517010567375e-09 5.42295538059913e-08 3.28102475299743 0.446428571428571 22.1 22 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00150078051343361 0.00871677824741238 3.21540425793748 0.4375 22.1 22 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00150078051343361 0.00871677824741238 3.21540425793748 0.4375 22.1 22 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00150078051343361 0.00871677824741238 3.21540425793748 0.4375 22.1 22 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 8.74411891325664e-08 1.41396377426866e-06 3.19543280291924 0.434782608695652 22.1 22 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.000155822542366547 0.00117944403078509 3.19543280291924 0.434782608695652 22.1 22 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 7.42199056341001e-10 4.22459702869298e-08 3.14978376287754 0.428571428571429 22.1 22 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000381164888740369 0.00263299823629876 3.14978376287754 0.428571428571429 22.1 22 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00374775667087633 0.0188447270058552 3.14978376287754 0.428571428571429 22.1 22 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00374775667087633 0.0188447270058552 3.14978376287754 0.428571428571429 22.1 22 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00374775667087633 0.0188447270058552 3.14978376287754 0.428571428571429 22.1 22 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 9.85979482674898e-05 0.000779471557692433 3.10940191976372 0.423076923076923 22.1 22 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 9.85979482674898e-05 0.000779471557692433 3.10940191976372 0.423076923076923 22.1 22 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.000933536904748391 0.00582266549680913 3.09452439861653 0.421052631578947 22.1 22 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 8.6676350813758e-08 1.41396377426866e-06 3.08678808761999 0.42 22.1 22 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 7.31305103444068e-10 4.22459702869298e-08 3.07143093295521 0.417910447761194 22.1 22 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00023851758720333 0.00173168636015479 3.06228976946427 0.416666666666667 22.1 22 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00023851758720333 0.00173168636015479 3.06228976946427 0.416666666666667 22.1 22 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0094077108397827 0.0392585704545771 3.06228976946427 0.416666666666667 22.1 22 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0094077108397827 0.0392585704545771 3.06228976946427 0.416666666666667 22.1 22 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0094077108397827 0.0392585704545771 3.06228976946427 0.416666666666667 22.1 22 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 5.53779655967262e-08 9.72874630174585e-07 3.05073395901346 0.415094339622642 22.1 22 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.62755044306293e-05 0.000138682891046619 3.02626283099999 0.411764705882353 22.1 22 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00228912545821482 0.0124329218589301 3.02626283099999 0.411764705882353 22.1 22 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00228912545821482 0.0124329218589301 3.02626283099999 0.411764705882353 22.1 22 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 9.49737750804476e-12 8.4467301212173e-10 3.02626283099999 0.411764705882353 22.1 22 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.64153726589422e-09 7.78635843122492e-08 2.98240394939129 0.405797101449275 22.1 22 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.83415520978769e-09 1.70500089485246e-07 2.96173697106395 0.402985074626866 22.1 22 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.04051119924982e-09 5.28802655904464e-08 2.96021344381546 0.402777777777778 22.1 22 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.70175702234341e-06 1.82804958064036e-05 2.9397981786857 0.4 22.1 22 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.70175702234341e-06 1.82804958064036e-05 2.9397981786857 0.4 22.1 22 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000355010755498007 0.00251333485111275 2.9397981786857 0.4 22.1 22 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00139346595004072 0.00829666128413366 2.9397981786857 0.4 22.1 22 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 3.51566675778902e-05 0.00029086010443801 2.85813711816665 0.388888888888889 22.1 22 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 3.51566675778902e-05 0.00029086010443801 2.85813711816665 0.388888888888889 22.1 22 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00336173595187336 0.0173954554891483 2.85813711816665 0.388888888888889 22.1 22 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00336173595187336 0.0173954554891483 2.85813711816665 0.388888888888889 22.1 22 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 8.75584817029929e-10 4.75873297415666e-08 2.84792948560177 0.3875 22.1 22 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 5.77248200140738e-06 5.47616125866846e-05 2.83957778623051 0.386363636363636 22.1 22 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000515268760017082 0.00344238237325966 2.82672901796702 0.384615384615385 22.1 22 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0137991260388315 0.0520786583005401 2.82672901796702 0.384615384615385 22.1 22 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0137991260388315 0.0520786583005401 2.82672901796702 0.384615384615385 22.1 22 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0137991260388315 0.0520786583005401 2.82672901796702 0.384615384615385 22.1 22 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0137991260388315 0.0520786583005401 2.82672901796702 0.384615384615385 22.1 22 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0137991260388315 0.0520786583005401 2.82672901796702 0.384615384615385 22.1 22 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 7.38388940646323e-09 2.69417298087107e-07 2.8189845549041 0.383561643835616 22.1 22 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.60913249272992e-07 2.36061395582957e-06 2.81730658790713 0.383333333333333 22.1 22 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.60913249272992e-07 2.36061395582957e-06 2.81730658790713 0.383333333333333 22.1 22 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.60913249272992e-07 2.36061395582957e-06 2.81730658790713 0.383333333333333 22.1 22 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.60913249272992e-07 2.36061395582957e-06 2.81730658790713 0.383333333333333 22.1 22 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.60913249272992e-07 2.36061395582957e-06 2.81730658790713 0.383333333333333 22.1 22 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.60913249272992e-07 2.36061395582957e-06 2.81730658790713 0.383333333333333 22.1 22 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.60913249272992e-07 2.36061395582957e-06 2.81730658790713 0.383333333333333 22.1 22 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00201642044930248 0.0112084621068649 2.79980778922448 0.380952380952381 22.1 22 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.86205688000704e-08 7.32760925366668e-07 2.76937509586334 0.376811594202899 22.1 22 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00121264644886824 0.00728099534489244 2.75606079251784 0.375 22.1 22 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00808968866912527 0.0344659490304349 2.75606079251784 0.375 22.1 22 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00808968866912527 0.0344659490304349 2.75606079251784 0.375 22.1 22 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00808968866912527 0.0344659490304349 2.75606079251784 0.375 22.1 22 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00808968866912527 0.0344659490304349 2.75606079251784 0.375 22.1 22 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.48761989136279e-08 4.2917394698337e-07 2.74381163343999 0.373333333333333 22.1 22 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.48761989136279e-08 4.2917394698337e-07 2.74381163343999 0.373333333333333 22.1 22 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.48761989136279e-08 4.2917394698337e-07 2.74381163343999 0.373333333333333 22.1 22 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.48761989136279e-08 4.2917394698337e-07 2.74381163343999 0.373333333333333 22.1 22 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.48761989136279e-08 4.2917394698337e-07 2.74381163343999 0.373333333333333 22.1 22 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 8.38118074881589e-13 9.17416938889616e-11 2.73328343059621 0.371900826446281 22.1 22 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 8.38118074881589e-13 9.17416938889616e-11 2.73328343059621 0.371900826446281 22.1 22 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.2295969788439e-07 4.46186068048045e-06 2.72642573023271 0.370967741935484 22.1 22 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000731063902827288 0.00477203639322583 2.72203535063491 0.37037037037037 22.1 22 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.37121550671239e-08 7.32760925366668e-07 2.71830653508609 0.36986301369863 22.1 22 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.16210904271085e-05 0.000106005203062662 2.71611788248135 0.369565217391304 22.1 22 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 6.8391895388612e-12 6.48811114253299e-10 2.70770884878946 0.368421052631579 22.1 22 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0047781853960296 0.0230486705713563 2.70770884878946 0.368421052631579 22.1 22 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0047781853960296 0.0230486705713563 2.70770884878946 0.368421052631579 22.1 22 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 7.13293155246121e-06 6.63409254846556e-05 2.69981465389503 0.36734693877551 22.1 22 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.29143701977957e-08 4.17662472533256e-07 2.69791605005966 0.367088607594937 22.1 22 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.29143701977957e-08 4.17662472533256e-07 2.69791605005966 0.367088607594937 22.1 22 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.000441720662787434 0.00300750479974411 2.69481499712856 0.366666666666667 22.1 22 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 4.37960558226567e-06 4.29805430590624e-05 2.68539256706867 0.365384615384615 22.1 22 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 4.94443914163319e-09 1.90160456717406e-07 2.68040422174284 0.364705882352941 22.1 22 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 4.94443914163319e-09 1.90160456717406e-07 2.68040422174284 0.364705882352941 22.1 22 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 4.94443914163319e-09 1.90160456717406e-07 2.68040422174284 0.364705882352941 22.1 22 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 7.6882109379662e-11 5.47016208236295e-09 2.65398446686903 0.361111111111111 22.1 22 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000162201403052644 0.00122123066954451 2.65398446686903 0.361111111111111 22.1 22 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.001695066526389 0.00976550472490502 2.64581836081713 0.36 22.1 22 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.47613237643758e-08 6.41068712216931e-07 2.63130083894708 0.358024691358025 22.1 22 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.47613237643758e-08 6.41068712216931e-07 2.63130083894708 0.358024691358025 22.1 22 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.39692440687219e-06 1.79083191980102e-05 2.60788548109215 0.354838709677419 22.1 22 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 5.51083851032215e-08 9.72874630174585e-07 2.60488446212657 0.354430379746835 22.1 22 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.66151839779578e-12 3.721671914331e-10 2.60059069652966 0.353846153846154 22.1 22 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.35944131251572e-05 0.000119412653562338 2.59393956942856 0.352941176470588 22.1 22 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.35944131251572e-05 0.000119412653562338 2.59393956942856 0.352941176470588 22.1 22 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000368529215793361 0.00259612412907898 2.59393956942856 0.352941176470588 22.1 22 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0112536322387128 0.0447316164125371 2.59393956942856 0.352941176470588 22.1 22 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0112536322387128 0.0447316164125371 2.59393956942856 0.352941176470588 22.1 22 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0112536322387128 0.0447316164125371 2.59393956942856 0.352941176470588 22.1 22 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.09042006819787e-08 5.83268187655995e-07 2.59393956942856 0.352941176470588 22.1 22 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.28788954074998e-08 4.17662472533256e-07 2.58902680509252 0.352272727272727 22.1 22 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000134968606011511 0.00103258239975474 2.57232340634999 0.35 22.1 22 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00660072663617744 0.0289902284051867 2.57232340634999 0.35 22.1 22 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00660072663617744 0.0289902284051867 2.57232340634999 0.35 22.1 22 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.84350819844837e-08 6.97640028688281e-07 2.56377748141195 0.348837209302326 22.1 22 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.63561979797645e-09 2.48486499276855e-07 2.55298262885863 0.347368421052632 22.1 22 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.84432327301005e-08 7.32760925366668e-07 2.53430877472905 0.344827586206897 22.1 22 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000301751051423551 0.00215774746821966 2.51430107387593 0.342105263157895 22.1 22 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.53115731749071e-10 9.47320375125776e-09 2.4893452319516 0.338709677419355 22.1 22 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.53115731749071e-10 9.47320375125776e-09 2.4893452319516 0.338709677419355 22.1 22 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.53115731749071e-10 9.47320375125776e-09 2.4893452319516 0.338709677419355 22.1 22 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.60815054459723e-08 6.51122495607345e-07 2.47561951889322 0.336842105263158 22.1 22 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.60815054459723e-08 6.51122495607345e-07 2.47561951889322 0.336842105263158 22.1 22 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00524570209078037 0.023925109215322 2.44983181557142 0.333333333333333 22.1 22 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00524570209078037 0.023925109215322 2.44983181557142 0.333333333333333 22.1 22 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 5.63652603963279e-08 9.78143482243593e-07 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.72142406047652e-06 1.82804958064036e-05 2.44983181557142 0.333333333333333 22.1 22 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000669071009551492 0.00440781503051747 2.44983181557142 0.333333333333333 22.1 22 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00889287972961494 0.0376624043310775 2.44983181557142 0.333333333333333 22.1 22 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00889287972961494 0.0376624043310775 2.44983181557142 0.333333333333333 22.1 22 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0151995803821325 0.0542080272776303 2.44983181557142 0.333333333333333 22.1 22 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0151995803821325 0.0542080272776303 2.44983181557142 0.333333333333333 22.1 22 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0262654061428393 0.0828728890050119 2.44983181557142 0.333333333333333 22.1 22 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.34281886785859e-15 3.18471874827128e-13 2.41483421820611 0.328571428571429 22.1 22 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.55798102208406e-16 7.28001398885125e-14 2.40588864399166 0.327354260089686 22.1 22 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.2779627888064e-08 6.23373278552212e-07 2.40271966527197 0.326923076923077 22.1 22 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.000118309405189479 0.000919968762757532 2.39983524790669 0.326530612244898 22.1 22 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.1303419807192e-08 3.96155896204872e-07 2.3836201448803 0.324324324324324 22.1 22 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.000883284443674809 0.00561122215780917 2.3836201448803 0.324324324324324 22.1 22 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 4.87556396512096e-06 4.75200515230625e-05 2.38082246865391 0.323943661971831 22.1 22 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 2.98277996917277e-08 7.19406084090313e-07 2.37983662084081 0.323809523809524 22.1 22 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00146907817985583 0.00863842252039194 2.37777793864285 0.323529411764706 22.1 22 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0041077142192222 0.020366819978931 2.36233782215815 0.321428571428571 22.1 22 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00691658941519984 0.0300987973633926 2.35183854294856 0.32 22.1 22 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00691658941519984 0.0300987973633926 2.35183854294856 0.32 22.1 22 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 6.35607861423973e-06 5.98986746229347e-05 2.34775548992261 0.319444444444444 22.1 22 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.000254897143454075 0.00183191229866236 2.34558365320668 0.319148936170213 22.1 22 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000254897143454075 0.00183191229866236 2.34558365320668 0.319148936170213 22.1 22 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0117179822495029 0.0456840787425824 2.33847582395453 0.318181818181818 22.1 22 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0117179822495029 0.0456840787425824 2.33847582395453 0.318181818181818 22.1 22 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 8.19283054066508e-08 1.35562765806586e-06 2.33205143982279 0.317307692307692 22.1 22 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0011516844708677 0.00697381702997762 2.32089329896239 0.315789473684211 22.1 22 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0200094549911031 0.0671543737083483 2.32089329896239 0.315789473684211 22.1 22 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0200094549911031 0.0671543737083483 2.32089329896239 0.315789473684211 22.1 22 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00191318654501598 0.0106763311904225 2.30984142611019 0.314285714285714 22.1 22 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00191318654501598 0.0106763311904225 2.30984142611019 0.314285714285714 22.1 22 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.32916632399266e-17 8.28600919760389e-15 2.2967173270982 0.3125 22.1 22 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000330043735848406 0.00234826118056141 2.2967173270982 0.3125 22.1 22 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0345270959036185 0.102358453064269 2.2967173270982 0.3125 22.1 22 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0345270959036185 0.102358453064269 2.2967173270982 0.3125 22.1 22 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.00054375616286742 0.00361572439140345 2.28650969453332 0.311111111111111 22.1 22 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.57823035114716e-07 4.89598249007924e-06 2.27834358848142 0.31 22.1 22 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000897458129508304 0.005650809372966 2.27484382874489 0.30952380952381 22.1 22 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000897458129508304 0.005650809372966 2.27484382874489 0.30952380952381 22.1 22 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00895966678023088 0.0377207273025696 2.26138321437362 0.307692307692308 22.1 22 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00895966678023088 0.0377207273025696 2.26138321437362 0.307692307692308 22.1 22 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0151377587667227 0.0542080272776303 2.23680296204347 0.304347826086957 22.1 22 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0151377587667227 0.0542080272776303 2.23680296204347 0.304347826086957 22.1 22 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0151377587667227 0.0542080272776303 2.23680296204347 0.304347826086957 22.1 22 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00409037525745016 0.020351762207523 2.22711983233765 0.303030303030303 22.1 22 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00409037525745016 0.020351762207523 2.22711983233765 0.303030303030303 22.1 22 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.27223574157127e-13 5.52671950932356e-11 2.20814437188276 0.300448430493274 22.1 22 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.00189214077495292 0.0106423570069486 2.20484863401427 0.3 22.1 22 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.00682172317023627 0.0298686525269114 2.20484863401427 0.3 22.1 22 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0257560528574998 0.0822299293120974 2.20484863401427 0.3 22.1 22 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0257560528574998 0.0822299293120974 2.20484863401427 0.3 22.1 22 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0257560528574998 0.0822299293120974 2.20484863401427 0.3 22.1 22 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00312792208471269 0.0163041506466892 2.18498513280694 0.297297297297297 22.1 22 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.90873775002481e-11 3.09007434349184e-09 2.18188146074329 0.296875 22.1 22 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0114210144500517 0.0448953137083524 2.17762828050793 0.296296296296296 22.1 22 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0114210144500517 0.0448953137083524 2.17762828050793 0.296296296296296 22.1 22 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0114210144500517 0.0448953137083524 2.17762828050793 0.296296296296296 22.1 22 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0114210144500517 0.0448953137083524 2.17762828050793 0.296296296296296 22.1 22 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.47777787575061e-08 6.41068712216931e-07 2.16783678644089 0.294964028776978 22.1 22 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0442243724306624 0.124370122468049 2.16161630785713 0.294117647058824 22.1 22 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0442243724306624 0.124370122468049 2.16161630785713 0.294117647058824 22.1 22 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0442243724306624 0.124370122468049 2.16161630785713 0.294117647058824 22.1 22 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0442243724306624 0.124370122468049 2.16161630785713 0.294117647058824 22.1 22 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00238745744346546 0.0126766863509379 2.15107183806271 0.292682926829268 22.1 22 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00238745744346546 0.0126766863509379 2.15107183806271 0.292682926829268 22.1 22 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00238745744346546 0.0126766863509379 2.15107183806271 0.292682926829268 22.1 22 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.12500346115044e-07 3.02387992521708e-06 2.15107183806271 0.292682926829268 22.1 22 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000151639636509094 0.00115392087033391 2.14831405365493 0.292307692307692 22.1 22 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0192109585744638 0.0652438998841575 2.14360283862499 0.291666666666667 22.1 22 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0192109585744638 0.0652438998841575 2.14360283862499 0.291666666666667 22.1 22 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0192109585744638 0.0652438998841575 2.14360283862499 0.291666666666667 22.1 22 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0192109585744638 0.0652438998841575 2.14360283862499 0.291666666666667 22.1 22 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.80010318159698e-13 2.5615468274125e-11 2.12004676347526 0.288461538461538 22.1 22 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000850327723102261 0.00542608228688124 2.12004676347526 0.288461538461538 22.1 22 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.55278095443848e-07 3.59664088927323e-06 2.10799481804982 0.286821705426357 22.1 22 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.62923923048994e-18 1.87070371249359e-15 2.10266313582467 0.286096256684492 22.1 22 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00298345716904833 0.0156083071748374 2.09985584191836 0.285714285714286 22.1 22 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0143463345423835 0.0520786583005401 2.09985584191836 0.285714285714286 22.1 22 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0143463345423835 0.0520786583005401 2.09985584191836 0.285714285714286 22.1 22 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0325013221086537 0.0986402205856871 2.09985584191836 0.285714285714286 22.1 22 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0325013221086537 0.0986402205856871 2.09985584191836 0.285714285714286 22.1 22 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00226295270789807 0.0123853142436113 2.07703132189751 0.282608695652174 22.1 22 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00226295270789807 0.0123853142436113 2.07703132189751 0.282608695652174 22.1 22 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0107309083079913 0.0436288072064903 2.06704559438838 0.28125 22.1 22 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0239921021363997 0.077416692381172 2.05785872507999 0.28 22.1 22 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0239921021363997 0.077416692381172 2.05785872507999 0.28 22.1 22 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0239921021363997 0.077416692381172 2.05785872507999 0.28 22.1 22 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.53046135512878e-09 1.90160456717406e-07 2.04822004252692 0.278688524590164 22.1 22 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0553877539877895 0.149217158025451 2.04152651297618 0.277777777777778 22.1 22 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0553877539877895 0.149217158025451 2.04152651297618 0.277777777777778 22.1 22 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0553877539877895 0.149217158025451 2.04152651297618 0.277777777777778 22.1 22 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0553877539877895 0.149217158025451 2.04152651297618 0.277777777777778 22.1 22 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.14141895603652e-08 3.96155896204872e-07 2.03460608411863 0.27683615819209 22.1 22 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.000988798218717842 0.00603888354178322 2.02744701978324 0.275862068965517 22.1 22 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.000988798218717842 0.00603888354178322 2.02744701978324 0.275862068965517 22.1 22 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.017780150798983 0.0611138999684852 2.02744701978324 0.275862068965517 22.1 22 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.017780150798983 0.0611138999684852 2.02744701978324 0.275862068965517 22.1 22 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.017780150798983 0.0611138999684852 2.02744701978324 0.275862068965517 22.1 22 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.68066562426348e-08 1.30114133134845e-06 2.02111124784642 0.275 22.1 22 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00210916999598936 0.0116331352879568 2.01750855399999 0.274509803921569 22.1 22 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.36439802720304e-06 2.43807129906516e-05 2.01518423538939 0.274193548387097 22.1 22 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.75541014127037e-05 0.000233389799465937 2.00440784910389 0.272727272727273 22.1 22 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00159552164350515 0.00922937926303997 2.00440784910389 0.272727272727273 22.1 22 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00453549691485685 0.0221027811980866 2.00440784910389 0.272727272727273 22.1 22 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00453549691485685 0.0221027811980866 2.00440784910389 0.272727272727273 22.1 22 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0402950745558352 0.115604619139019 2.00440784910389 0.272727272727273 22.1 22 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0132211082019443 0.0509854660470642 2.00440784910389 0.272727272727273 22.1 22 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000433488050078748 0.00296564180414451 1.99486304982244 0.271428571428571 22.1 22 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00341388107733862 0.017601278163235 1.99048835015178 0.270833333333333 22.1 22 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00985961972271303 0.0404329650300307 1.98635012073358 0.27027027027027 22.1 22 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0295303677939357 0.0909560895471223 1.97871031257691 0.269230769230769 22.1 22 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.0295303677939357 0.0909560895471223 1.97871031257691 0.269230769230769 22.1 22 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00737123303624044 0.0319794652761285 1.97181585155748 0.268292682926829 22.1 22 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 4.74165975482137e-09 1.90160456717406e-07 1.95986545245713 0.266666666666667 22.1 22 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.00011052752660299 0.000868953979867706 1.95986545245713 0.266666666666667 22.1 22 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0217650335730728 0.0720270762197269 1.95986545245713 0.266666666666667 22.1 22 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0217650335730728 0.0720270762197269 1.95986545245713 0.266666666666667 22.1 22 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0217650335730728 0.0720270762197269 1.95986545245713 0.266666666666667 22.1 22 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00110884218341295 0.00674308729485737 1.95220972803347 0.265625 22.1 22 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00414587293970021 0.020413761914164 1.94986613892419 0.26530612244898 22.1 22 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00414587293970021 0.020413761914164 1.94986613892419 0.26530612244898 22.1 22 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.016114977500323 0.0562049337817637 1.94545467707142 0.264705882352941 22.1 22 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.016114977500323 0.0562049337817637 1.94545467707142 0.264705882352941 22.1 22 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.016114977500323 0.0562049337817637 1.94545467707142 0.264705882352941 22.1 22 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.05020947699233e-05 9.64160055329084e-05 1.94366821731286 0.264462809917355 22.1 22 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0680228607723203 0.172235820069416 1.93407774913533 0.263157894736842 22.1 22 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00133635647627821 0.00799006414178109 1.92217573221757 0.261538461538462 22.1 22 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0491741271872866 0.134566890360594 1.91725968175154 0.260869565217391 22.1 22 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0491741271872866 0.134566890360594 1.91725968175154 0.260869565217391 22.1 22 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.51110834574621e-05 0.00013111629121932 1.91206385605574 0.260162601626016 22.1 22 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0358686414642951 0.105456770255562 1.90542474544444 0.259259259259259 22.1 22 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0358686414642951 0.105456770255562 1.90542474544444 0.259259259259259 22.1 22 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0263408691228839 0.0829271167297873 1.89664398624884 0.258064516129032 22.1 22 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00120947535930547 0.00728099534489244 1.88987025772652 0.257142857142857 22.1 22 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0194465825450815 0.0655746136532013 1.88987025772652 0.257142857142857 22.1 22 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0194465825450815 0.0655746136532013 1.88987025772652 0.257142857142857 22.1 22 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.0194465825450815 0.0655746136532013 1.88987025772652 0.257142857142857 22.1 22 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.58368222719964e-06 1.82804958064036e-05 1.88330820822053 0.25625 22.1 22 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.33855057515621e-05 0.000119047341777956 1.85059237866906 0.251798561151079 22.1 22 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.19656345722291e-14 2.12838724953526e-12 1.84561320634977 0.251121076233184 22.1 22 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000558662748812855 0.00369756786772415 1.83737386167856 0.25 22.1 22 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00953507493795605 0.0396678700349123 1.83737386167856 0.25 22.1 22 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0430427437715989 0.122011602364512 1.83737386167856 0.25 22.1 22 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.07905516488656e-07 1.06449032404015e-05 1.83737386167856 0.25 22.1 22 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 7.0084497233294e-06 6.56119997124851e-05 1.83737386167856 0.25 22.1 22 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.58115102175186e-05 0.000135540837587524 1.83737386167856 0.25 22.1 22 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0172126700132991 0.0595952054231744 1.83737386167856 0.25 22.1 22 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0821117967439271 0.197461092729733 1.83737386167856 0.25 22.1 22 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0821117967439271 0.197461092729733 1.83737386167856 0.25 22.1 22 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0821117967439271 0.197461092729733 1.83737386167856 0.25 22.1 22 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0821117967439271 0.197461092729733 1.83737386167856 0.25 22.1 22 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000499455326679788 0.00335247608427046 1.81761715348847 0.247311827956989 22.1 22 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0203873271026729 0.0682615681578907 1.79255986505226 0.24390243902439 22.1 22 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0275523277476004 0.0859801806684986 1.78771510866022 0.243243243243243 22.1 22 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0275523277476004 0.0859801806684986 1.78771510866022 0.243243243243243 22.1 22 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0510808415356131 0.139516386766175 1.77401614231034 0.241379310344828 22.1 22 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00209966231302281 0.0116257566981769 1.76760017072874 0.240506329113924 22.1 22 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.0132672046882596 0.0510249520848472 1.76387890721142 0.24 22.1 22 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.070268086244068 0.176041349868501 1.76387890721142 0.24 22.1 22 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.070268086244068 0.176041349868501 1.76387890721142 0.24 22.1 22 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.070268086244068 0.176041349868501 1.76387890721142 0.24 22.1 22 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.21947813978919e-05 0.00026948925840706 1.74314956107966 0.237179487179487 22.1 22 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.000476047585989758 0.00322578911839727 1.73715346922337 0.236363636363636 22.1 22 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0115910064078893 0.0454380223648111 1.73715346922337 0.236363636363636 22.1 22 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 0.000185121346736012 0.00138646145476497 1.73610128662541 0.236220472440945 22.1 22 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.49945990217817e-05 0.000759423114651659 1.73238106958264 0.235714285714286 22.1 22 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.73154858732618e-05 0.000305172048262365 1.73204669763329 0.235668789808917 22.1 22 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.51813239073031e-22 3.58330239200923e-19 1.72929304628571 0.235294117647059 22.1 22 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.0101063452240145 0.0413256587752086 1.71488227089999 0.233333333333333 22.1 22 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0600030439589948 0.15504596065919 1.71488227089999 0.233333333333333 22.1 22 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0600030439589948 0.15504596065919 1.71488227089999 0.233333333333333 22.1 22 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.98427447590019e-05 0.00040529271881177 1.71025994671967 0.232704402515723 22.1 22 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0279807354034319 0.0871260098010583 1.70918498760797 0.232558139534884 22.1 22 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0377767579838625 0.109931138263878 1.69603741078021 0.230769230769231 22.1 22 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0377767579838625 0.109931138263878 1.69603741078021 0.230769230769231 22.1 22 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0377767579838625 0.109931138263878 1.69603741078021 0.230769230769231 22.1 22 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0824894017791078 0.197461092729733 1.69603741078021 0.230769230769231 22.1 22 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0824894017791078 0.197461092729733 1.69603741078021 0.230769230769231 22.1 22 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.00049138326040203 0.00331392596944118 1.68676944678688 0.229508196721311 22.1 22 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.051222125111305 0.139634260600358 1.67988467353469 0.228571428571429 22.1 22 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 8.73183410868624e-18 4.14179997888684e-15 1.67504505699761 0.227912932138284 22.1 22 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0324482353627845 0.0986402205856871 1.67033987425324 0.227272727272727 22.1 22 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0698211782861939 0.175850507435848 1.65956348796773 0.225806451612903 22.1 22 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00380771205445384 0.0190787825827036 1.65157201049758 0.224719101123595 22.1 22 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.56274112810261e-05 0.00013477458335091 1.64488707616938 0.223809523809524 22.1 22 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 5.5370060775723e-11 4.14692613072915e-09 1.6431798762979 0.223577235772358 22.1 22 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00501730896599514 0.023925109215322 1.64282839397142 0.223529411764706 22.1 22 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00501730896599514 0.023925109215322 1.64282839397142 0.223529411764706 22.1 22 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.00287828021285268 0.0151136263575253 1.63322121038094 0.222222222222222 22.1 22 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0239471807107871 0.077416692381172 1.63322121038094 0.222222222222222 22.1 22 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0958096190119113 0.223503422711393 1.63322121038094 0.222222222222222 22.1 22 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0958096190119113 0.223503422711393 1.63322121038094 0.222222222222222 22.1 22 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0958096190119113 0.223503422711393 1.63322121038094 0.222222222222222 22.1 22 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.17096065881329e-06 2.27152721874362e-05 1.63322121038094 0.222222222222222 22.1 22 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0043555147508507 0.0213720603119329 1.63322121038094 0.222222222222222 22.1 22 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0373926554476679 0.10948507963381 1.63322121038094 0.222222222222222 22.1 22 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0592145334100005 0.15504596065919 1.63322121038094 0.222222222222222 22.1 22 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0592145334100005 0.15504596065919 1.63322121038094 0.222222222222222 22.1 22 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0205839021490263 0.0687579642208085 1.61938035266585 0.220338983050847 22.1 22 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00754844530550073 0.0326487467164971 1.61330387854703 0.219512195121951 22.1 22 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 8.57276450473382e-05 0.000689211519222385 1.61138670222077 0.219251336898396 22.1 22 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 0.000190246784991742 0.00141738835101177 1.6090611333043 0.218934911242604 22.1 22 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 0.000215503015737116 0.00158891601758506 1.59959606781428 0.217647058823529 22.1 22 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00564735829470359 0.0254309837131747 1.59771640145962 0.217391304347826 22.1 22 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0428337942597541 0.121661655152954 1.59771640145962 0.217391304347826 22.1 22 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.13261271591271 0.286354923738675 1.59771640145962 0.217391304347826 22.1 22 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.13261271591271 0.286354923738675 1.59771640145962 0.217391304347826 22.1 22 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.000718206366393975 0.00470971271603054 1.59324726467232 0.216783216783217 22.1 22 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.50282576605336e-06 3.48567906649925e-05 1.59194847221247 0.216606498194946 22.1 22 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 9.93784651585248e-06 9.18282830653122e-05 1.58518529242856 0.215686274509804 22.1 22 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.62448948986275e-06 2.6676061029105e-05 1.5802669390546 0.215017064846416 22.1 22 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.110200584986542 0.249673938148885 1.57489188143877 0.214285714285714 22.1 22 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.110200584986542 0.249673938148885 1.57489188143877 0.214285714285714 22.1 22 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.00178236190350531 0.0100646864630478 1.55898388263636 0.212121212121212 22.1 22 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0921509705065597 0.217464064727752 1.55898388263636 0.212121212121212 22.1 22 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0921509705065597 0.217464064727752 1.55898388263636 0.212121212121212 22.1 22 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.0109990870898259 0.0440892983910486 1.55636374165714 0.211764705882353 22.1 22 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.0109990870898259 0.0440892983910486 1.55636374165714 0.211764705882353 22.1 22 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.0109990870898259 0.0440892983910486 1.55636374165714 0.211764705882353 22.1 22 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.0109990870898259 0.0440892983910486 1.55636374165714 0.211764705882353 22.1 22 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.0109990870898259 0.0440892983910486 1.55636374165714 0.211764705882353 22.1 22 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.0046571311925646 0.0226180808430697 1.55081096582044 0.211009174311927 22.1 22 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0774323088260826 0.188998585693852 1.54726219930826 0.210526315789474 22.1 22 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0144198744603103 0.0520799019213744 1.54248669869311 0.209876543209877 22.1 22 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.0144198744603103 0.0520799019213744 1.54248669869311 0.209876543209877 22.1 22 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.96855168642833e-09 9.03628725737906e-08 1.54146720979775 0.209737827715356 22.1 22 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.012393223229985 0.0480532878917403 1.53826648884717 0.209302325581395 22.1 22 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.012393223229985 0.0480532878917403 1.53826648884717 0.209302325581395 22.1 22 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00523521796249262 0.023925109215322 1.53671268431298 0.209090909090909 22.1 22 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.000977793474679111 0.00602337711891071 1.53502120089601 0.208860759493671 22.1 22 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.000847543503914005 0.00542608228688124 1.53302359011217 0.208588957055215 22.1 22 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.151941891137574 0.317595007635002 1.53114488473214 0.208333333333333 22.1 22 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0468990082658572 0.129085664917437 1.52536697950673 0.207547169811321 22.1 22 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000116314645195991 0.000909427143482938 1.51405914782096 0.206008583690987 22.1 22 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.00762493366308135 0.0328796381895902 1.51111121334312 0.205607476635514 22.1 22 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0212194198124206 0.0707148346442028 1.50758880958241 0.205128205128205 22.1 22 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0876659993660103 0.207568580861618 1.50758880958241 0.205128205128205 22.1 22 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.0155972721168339 0.0554034152926977 1.50330588682791 0.204545454545455 22.1 22 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.0622999575001059 0.159161291782138 1.49989702994168 0.204081632653061 22.1 22 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00175698895655687 0.00996093739115705 1.49798633308826 0.203821656050955 22.1 22 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.052770406012503 0.143305892663725 1.4971194428492 0.203703703703704 22.1 22 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.052770406012503 0.143305892663725 1.4971194428492 0.203703703703704 22.1 22 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.044810607656213 0.125770206498602 1.49481263323002 0.203389830508475 22.1 22 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.59721683281804e-14 2.5253772812223e-12 1.49344101669969 0.203203203203203 22.1 22 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.0381329159481186 0.110741100804434 1.49286626261383 0.203125 22.1 22 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.0325103748803143 0.0986402205856871 1.49120197469564 0.202898550724638 22.1 22 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.26951935370955e-05 0.000114813198723666 1.48793466099123 0.202453987730061 22.1 22 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.00278689795998545 0.0146879844335529 1.46989908934285 0.2 22.1 22 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 8.94955916245861e-08 1.43092389754816e-06 1.46710460438212 0.199619771863118 22.1 22 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.76559886801435e-08 8.89529652600681e-07 1.45445356476131 0.197898423817863 22.1 22 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.0294484662265407 0.0909560895471223 1.45175218700528 0.197530864197531 22.1 22 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0344764653527279 0.102358453064269 1.4505583118515 0.197368421052632 22.1 22 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0558908961542976 0.149217158025451 1.44580238296018 0.19672131147541 22.1 22 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.0558908961542976 0.149217158025451 1.44580238296018 0.19672131147541 22.1 22 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0558908961542976 0.149217158025451 1.44580238296018 0.19672131147541 22.1 22 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0558908961542976 0.149217158025451 1.44580238296018 0.19672131147541 22.1 22 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.0558908961542976 0.149217158025451 1.44580238296018 0.19672131147541 22.1 22 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.0780121883088584 0.190087917745728 1.44107753857142 0.196078431372549 22.1 22 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.50798997534564e-08 4.2917394698337e-07 1.44018106731881 0.195956454121306 22.1 22 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 0.000808697787729351 0.00520713552913514 1.43649229185779 0.195454545454545 22.1 22 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.110361846167006 0.249673938148885 1.4340478920418 0.195121951219512 22.1 22 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.110361846167006 0.249673938148885 1.4340478920418 0.195121951219512 22.1 22 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.110361846167006 0.249673938148885 1.4340478920418 0.195121951219512 22.1 22 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.110361846167006 0.249673938148885 1.4340478920418 0.195121951219512 22.1 22 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.110361846167006 0.249673938148885 1.4340478920418 0.195121951219512 22.1 22 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.08103067035877e-06 4.88534232697333e-05 1.43194394853822 0.194835680751174 22.1 22 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.132190716875104 0.286312618132835 1.42906855908333 0.194444444444444 22.1 22 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.159357820056367 0.325346022869741 1.42248298968663 0.193548387096774 22.1 22 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.159357820056367 0.325346022869741 1.42248298968663 0.193548387096774 22.1 22 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0732555794700813 0.18066324018358 1.41832368269924 0.192982456140351 22.1 22 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0361123776987464 0.105954460753229 1.41677020659552 0.192771084337349 22.1 22 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.0184028409199019 0.063101789467519 1.41595783835779 0.192660550458716 22.1 22 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0867083964306715 0.205643413534743 1.41336450898351 0.192307692307692 22.1 22 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.193758185356628 0.381352555688079 1.41336450898351 0.192307692307692 22.1 22 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.193758185356628 0.381352555688079 1.41336450898351 0.192307692307692 22.1 22 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.193758185356628 0.381352555688079 1.41336450898351 0.192307692307692 22.1 22 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.193758185356628 0.381352555688079 1.41336450898351 0.192307692307692 22.1 22 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.102977397735888 0.239439276108118 1.40735019192401 0.191489361702128 22.1 22 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.0686721820282872 0.173263324514632 1.39990389461224 0.19047619047619 22.1 22 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0686721820282872 0.173263324514632 1.39990389461224 0.19047619047619 22.1 22 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.122799256506832 0.26801126075034 1.39990389461224 0.19047619047619 22.1 22 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.0466457645267427 0.128637447522393 1.39547381899638 0.189873417721519 22.1 22 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.0810661499115343 0.197191677477117 1.39386982610098 0.189655172413793 22.1 22 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.0643025013513162 0.163397248969505 1.38468754793167 0.188405797101449 22.1 22 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.0643025013513162 0.163397248969505 1.38468754793167 0.188405797101449 22.1 22 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.177546839644175 0.355229641466064 1.37803039625892 0.1875 22.1 22 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.177546839644175 0.355229641466064 1.37803039625892 0.1875 22.1 22 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.64349016407253e-15 5.37383786210743e-13 1.3759546026773 0.187217559715946 22.1 22 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.0706859354928365 0.176776952910908 1.36490629724693 0.185714285714286 22.1 22 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.105783663602348 0.245563055964342 1.36101767531745 0.185185185185185 22.1 22 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.216019223162245 0.406432787097951 1.36101767531745 0.185185185185185 22.1 22 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.216019223162245 0.406432787097951 1.36101767531745 0.185185185185185 22.1 22 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.216019223162245 0.406432787097951 1.36101767531745 0.185185185185185 22.1 22 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.0659657725234565 0.167324945277859 1.35385442439473 0.184210526315789 22.1 22 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.162930049860597 0.330741028461669 1.35385442439473 0.184210526315789 22.1 22 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.098181881783774 0.228662549555336 1.34740749856428 0.183333333333333 22.1 22 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.00235123992106705 0.0126257147459563 1.34157456567006 0.182539682539683 22.1 22 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.00235123992106705 0.0126257147459563 1.34157456567006 0.182539682539683 22.1 22 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.00235123992106705 0.0126257147459563 1.34157456567006 0.182539682539683 22.1 22 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0136609367802629 0.0520786583005401 1.34047401229379 0.182389937106918 22.1 22 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0136609367802629 0.0520786583005401 1.34047401229379 0.182389937106918 22.1 22 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.116154665810506 0.256658523988121 1.33627189940259 0.181818181818182 22.1 22 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.116154665810506 0.256658523988121 1.33627189940259 0.181818181818182 22.1 22 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.116154665810506 0.256658523988121 1.33627189940259 0.181818181818182 22.1 22 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.116154665810506 0.256658523988121 1.33627189940259 0.181818181818182 22.1 22 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.196523699452534 0.383152420043735 1.33627189940259 0.181818181818182 22.1 22 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.196523699452534 0.383152420043735 1.33627189940259 0.181818181818182 22.1 22 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.0171330678832012 0.0594642819458424 1.32765079037419 0.180645161290323 22.1 22 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0171330678832012 0.0594642819458424 1.32765079037419 0.180645161290323 22.1 22 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.0260984740171758 0.0825291745032026 1.32622474226423 0.180451127819549 22.1 22 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 0.0106377108433479 0.0433738181377769 1.32531885104683 0.180327868852459 22.1 22 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0323190817293797 0.0986402205856871 1.32531885104683 0.180327868852459 22.1 22 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0130663818139178 0.0505257101119701 1.32461836539617 0.180232558139535 22.1 22 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0264793418033215 0.0831790361724646 1.31240990119897 0.178571428571429 22.1 22 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.127070893617334 0.276063941400711 1.31240990119897 0.178571428571429 22.1 22 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.0855451237662629 0.203563062072562 1.30244223106328 0.177215189873418 22.1 22 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0331150611354553 0.100261131905857 1.29696978471428 0.176470588235294 22.1 22 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.216211960529268 0.406432787097951 1.29696978471428 0.176470588235294 22.1 22 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.216211960529268 0.406432787097951 1.29696978471428 0.176470588235294 22.1 22 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0309353686821576 0.0950778177855514 1.29392525470321 0.176056338028169 22.1 22 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0357435125871347 0.105456770255562 1.28750285197914 0.175182481751825 22.1 22 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0357435125871347 0.105456770255562 1.28750285197914 0.175182481751825 22.1 22 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.1965224894447 0.383152420043735 1.28616170317499 0.175 22.1 22 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.1965224894447 0.383152420043735 1.28616170317499 0.175 22.1 22 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.127565611032421 0.276716256858438 1.28324523672789 0.174603174603175 22.1 22 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0271771790532117 0.0851830964597363 1.2781731211677 0.173913043478261 22.1 22 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.179292436818926 0.35633119775605 1.2781731211677 0.173913043478261 22.1 22 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.179292436818926 0.35633119775605 1.2781731211677 0.173913043478261 22.1 22 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.047756003395435 0.131190719752324 1.2731409435253 0.173228346456693 22.1 22 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0292202411775543 0.0905891137160342 1.27028316362962 0.172839506172839 22.1 22 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.0638605554337958 0.162855860900164 1.26945830443246 0.172727272727273 22.1 22 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.262648305811077 0.460849000208585 1.26715438736453 0.172413793103448 22.1 22 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0313789085943065 0.0962331614864184 1.2624900153865 0.171779141104294 22.1 22 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.0859382958585775 0.204157253767539 1.24941422594142 0.17 22.1 22 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.17798927221736 0.355229641466064 1.24802752868733 0.169811320754717 22.1 22 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.17798927221736 0.355229641466064 1.24802752868733 0.169811320754717 22.1 22 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.13751566558373 0.292066853918878 1.24216824451508 0.169014084507042 22.1 22 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0334236352261897 0.10098053699972 1.23153707485482 0.167567567567568 22.1 22 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0290975616937357 0.0904057429916723 1.23113375503335 0.16751269035533 22.1 22 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.211138979197464 0.400601023197322 1.22491590778571 0.166666666666667 22.1 22 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.125575762857945 0.273232890744428 1.22491590778571 0.166666666666667 22.1 22 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.125575762857945 0.273232890744428 1.22491590778571 0.166666666666667 22.1 22 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.148088010295969 0.313585176564232 1.22491590778571 0.166666666666667 22.1 22 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.257399644127727 0.452756110746298 1.22491590778571 0.166666666666667 22.1 22 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.286772337482154 0.497654922240372 1.22491590778571 0.166666666666667 22.1 22 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.173352198875877 0.347926909732544 1.20663358080383 0.164179104477612 22.1 22 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.20735390596577 0.393944737235367 1.20264470946233 0.163636363636364 22.1 22 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.20735390596577 0.393944737235367 1.20264470946233 0.163636363636364 22.1 22 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.20735390596577 0.393944737235367 1.20264470946233 0.163636363636364 22.1 22 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.251340317215363 0.444294747077592 1.19642949132558 0.162790697674419 22.1 22 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.251340317215363 0.444294747077592 1.19642949132558 0.162790697674419 22.1 22 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.170460188403141 0.342605717652075 1.19181007244015 0.162162162162162 22.1 22 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.170460188403141 0.342605717652075 1.19181007244015 0.162162162162162 22.1 22 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.185892186102813 0.368418636245547 1.18888896932142 0.161764705882353 22.1 22 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.203194858726767 0.387595554917144 1.18540249140552 0.161290322580645 22.1 22 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.311275129294806 0.522527608342664 1.18540249140552 0.161290322580645 22.1 22 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.153967897561237 0.317595007635002 1.18267742820689 0.160919540229885 22.1 22 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.153967897561237 0.317595007635002 1.18267742820689 0.160919540229885 22.1 22 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.119059234249527 0.262199169183603 1.18116891107908 0.160714285714286 22.1 22 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.139450204277017 0.295734188802079 1.17591927147428 0.16 22.1 22 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.244964833896572 0.438249773169149 1.17591927147428 0.16 22.1 22 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.136949744663467 0.292066853918878 1.16767684667423 0.158878504672897 22.1 22 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.178457643755416 0.355665584123188 1.16516391228397 0.158536585365854 22.1 22 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.194380922689453 0.382049796943497 1.1604466494812 0.157894736842105 22.1 22 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.0772314709548705 0.188832273485878 1.1483586635491 0.15625 22.1 22 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.1174358964552 0.25908725683062 1.14672978601215 0.156028368794326 22.1 22 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.254683824473529 0.4490893212216 1.14043894862807 0.155172413793103 22.1 22 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.191591531009482 0.379186020342828 1.12492277245626 0.153061224489796 22.1 22 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.23986533144642 0.430970159909414 1.1228395821369 0.152777777777778 22.1 22 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.23986533144642 0.430970159909414 1.1228395821369 0.152777777777778 22.1 22 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 2.64384499098073e-06 2.6682208667841e-05 1.12214247552271 0.152682926829268 22.1 22 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.15212814671829 0.317595007635002 1.12206037354416 0.152671755725191 22.1 22 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.15212814671829 0.317595007635002 1.12206037354416 0.152671755725191 22.1 22 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.271193507014145 0.472348054444465 1.12110947492251 0.152542372881356 22.1 22 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.271193507014145 0.472348054444465 1.12110947492251 0.152542372881356 22.1 22 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.122508436234797 0.267787257699104 1.12034991565766 0.152439024390244 22.1 22 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.360953185936421 0.580380094449182 1.11355991616883 0.151515151515152 22.1 22 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.360953185936421 0.580380094449182 1.11355991616883 0.151515151515152 22.1 22 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.360953185936421 0.580380094449182 1.11355991616883 0.151515151515152 22.1 22 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.360953185936421 0.580380094449182 1.11355991616883 0.151515151515152 22.1 22 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.254199361299861 0.448791180061665 1.10745821799804 0.150684931506849 22.1 22 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.213545721457945 0.404089842599277 1.10242431700714 0.15 22.1 22 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.278105800539425 0.483204583843225 1.09693961891257 0.149253731343284 22.1 22 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.278105800539425 0.483204583843225 1.09693961891257 0.149253731343284 22.1 22 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.260077126715028 0.456900927549982 1.08881414025396 0.148148148148148 22.1 22 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.385908569627308 0.608142737219208 1.08080815392857 0.147058823529412 22.1 22 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.385908569627308 0.608142737219208 1.08080815392857 0.147058823529412 22.1 22 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.367035088338422 0.587473260611262 1.07553591903135 0.146341463414634 22.1 22 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.350514606912884 0.567689366953936 1.07180141931249 0.145833333333333 22.1 22 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.335758282527738 0.548546539652091 1.06901751952207 0.145454545454545 22.1 22 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.298818431338168 0.505010246786477 1.06374276202443 0.144736842105263 22.1 22 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.0615808080137382 0.157606996049549 1.05417005397316 0.143434343434343 22.1 22 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.255620541118807 0.450183205460473 1.04992792095918 0.142857142857143 22.1 22 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.317352261051763 0.522527608342664 1.03757582777142 0.141176470588235 22.1 22 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.317352261051763 0.522527608342664 1.03757582777142 0.141176470588235 22.1 22 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.357504790571406 0.577445308720898 1.03352279719419 0.140625 22.1 22 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.29795043910897 0.505010246786477 1.03030310000667 0.14018691588785 22.1 22 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.411844563931203 0.625458713419532 1.02551099256478 0.13953488372093 22.1 22 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.23198089522921 0.419452114245446 1.00354556300516 0.136546184738956 22.1 22 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.460049871134219 0.689230289997973 0.993175060366791 0.135135135135135 22.1 22 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.363197134368147 0.583329031835071 0.989355156288457 0.134615384615385 22.1 22 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.318485417958572 0.522727508367991 0.985907925778741 0.134146341463415 22.1 22 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.409944757791179 0.623238664889795 0.979932726228567 0.133333333333333 22.1 22 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.408855740856573 0.622247828062999 0.974029517034419 0.132530120481928 22.1 22 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.406405141673598 0.620509137984474 0.965085260679649 0.131313131313131 22.1 22 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.449570574130241 0.675542689532558 0.963868255306787 0.131147540983607 22.1 22 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.499913118381316 0.726627893767561 0.93823346128267 0.127659574468085 22.1 22 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.454762165254502 0.682622954807126 0.92592068620022 0.125984251968504 22.1 22 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.551535326722777 0.780930119329863 0.887008071155168 0.120689655172414 22.1 22 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.551535326722777 0.780930119329863 0.887008071155168 0.120689655172414 22.1 22 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.551535326722777 0.780930119329863 0.887008071155168 0.120689655172414 22.1 22 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.562784128147088 0.794485926937804 0.88193945360571 0.12 22.1 22 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.580180978712458 0.81742329971072 0.860047339509114 0.117021276595745 22.1 22 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.602511134724364 0.833210247534276 0.848018705390106 0.115384615384615 22.1 22 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.602511134724364 0.833210247534276 0.848018705390106 0.115384615384615 22.1 22 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.611158991562185 0.844348781546592 0.839942336767343 0.114285714285714 22.1 22 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.645916365085804 0.868751405970793 0.835824972371425 0.113725490196078 22.1 22 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.621619654516777 0.85136166350084 0.832018352458217 0.113207547169811 22.1 22 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.627583840479996 0.858703658656763 0.828112163010056 0.112676056338028 22.1 22 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.659131265031991 0.883186243070172 0.79885820072981 0.108695652173913 22.1 22 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.659131265031991 0.883186243070172 0.79885820072981 0.108695652173913 22.1 22 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.690353389504626 0.909604512282484 0.779491941318178 0.106060606060606 22.1 22 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.738986851668314 0.947367828760371 0.757679942960232 0.103092783505155 22.1 22 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.713832648619807 0.929091943293087 0.749948514970842 0.102040816326531 22.1 22 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.734542165067415 0.943548722258962 0.745600987347822 0.101449275362319 22.1 22 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.817253642580122 1 0.696267989688719 0.0947368421052632 22.1 22 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.923220745047873 1 0.558189527598551 0.0759493670886076 22.1 22 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.99999997183991 1 0.536864906686935 0.0730478589420655 22.1 22 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999803210517733 1 0.492491962924151 0.0670103092783505 22.1 22 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.998154809030998 1 0.434647580182026 0.0591397849462366 22.1 22 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999999999955 1 0.405351918851328 0.0551537070524412 22.1 22 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999844992719597 1 0.37255506872745 0.0506912442396313 22.1 22 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999981047101056 1 0.367474772335713 0.05 22.1 22 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.997459626146116 1 0.340254418829363 0.0462962962962963 22.1 22 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99994534209919 1 0.292309477994317 0.0397727272727273 22.1 22 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 6.72413631519042e-06 3.92149425267048e-05 3.42987725254636 1 22.4 22 4 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.000585601714559674 0.00204744776368161 3.42987725254636 1 22.4 22 4 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.000585601714559674 0.00204744776368161 3.42987725254636 1 22.4 22 4 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.000585601714559674 0.00204744776368161 3.42987725254636 1 22.4 22 4 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 4.83838047795828e-05 0.000229500514004488 3.04877978004121 0.888888888888889 22.4 22 4 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 4.83838047795828e-05 0.000229500514004488 3.04877978004121 0.888888888888889 22.4 22 4 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 6.61692577570239e-08 5.63825471785898e-07 3.00114259597806 0.875 22.4 22 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.000191396638685904 0.000769398543936404 3.00114259597806 0.875 22.4 22 4 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.000191396638685904 0.000769398543936404 3.00114259597806 0.875 22.4 22 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.4773470494407e-09 1.60478232927795e-08 2.93989478789688 0.857142857142857 22.4 22 4 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.000746038610120947 0.00255195418798584 2.93989478789688 0.857142857142857 22.4 22 4 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00285297614107938 0.00803917831436823 2.85823104378863 0.833333333333333 22.4 22 4 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00285297614107938 0.00803917831436823 2.85823104378863 0.833333333333333 22.4 22 4 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00019356618322504 0.000769398543936404 2.74390180203709 0.8 22.4 22 4 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00019356618322504 0.000769398543936404 2.74390180203709 0.8 22.4 22 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00019356618322504 0.000769398543936404 2.74390180203709 0.8 22.4 22 4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00019356618322504 0.000769398543936404 2.74390180203709 0.8 22.4 22 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00019356618322504 0.000769398543936404 2.74390180203709 0.8 22.4 22 4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 1.40380925505896e-05 7.62450599217139e-05 2.69490355557214 0.785714285714286 22.4 22 4 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.000691941557358029 0.00238988552456426 2.66768230753606 0.777777777777778 22.4 22 4 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.000691941557358029 0.00238988552456426 2.66768230753606 0.777777777777778 22.4 22 4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 4.9235405744601e-05 0.000232764061045074 2.63836711734335 0.769230769230769 22.4 22 4 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 3.65555644845193e-06 2.18565412863324e-05 2.62284731077074 0.764705882352941 22.4 22 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 1.2478971063967e-05 6.82983685539426e-05 2.57240793940977 0.75 22.4 22 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 1.2478971063967e-05 6.82983685539426e-05 2.57240793940977 0.75 22.4 22 4 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 1.2478971063967e-05 6.82983685539426e-05 2.57240793940977 0.75 22.4 22 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000169268802540775 0.000690170504342471 2.57240793940977 0.75 22.4 22 4 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.000169268802540775 0.000690170504342471 2.57240793940977 0.75 22.4 22 4 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.000169268802540775 0.000690170504342471 2.57240793940977 0.75 22.4 22 4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.000169268802540775 0.000690170504342471 2.57240793940977 0.75 22.4 22 4 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00240996452442608 0.00705019449707311 2.57240793940977 0.75 22.4 22 4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00240996452442608 0.00705019449707311 2.57240793940977 0.75 22.4 22 4 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.00240996452442608 0.00705019449707311 2.57240793940977 0.75 22.4 22 4 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00240996452442608 0.00705019449707311 2.57240793940977 0.75 22.4 22 4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00240996452442608 0.00705019449707311 2.57240793940977 0.75 22.4 22 4 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00240996452442608 0.00705019449707311 2.57240793940977 0.75 22.4 22 4 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00240996452442608 0.00705019449707311 2.57240793940977 0.75 22.4 22 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 1.90365282594083e-08 1.67215924155173e-07 2.54064981670101 0.740740740740741 22.4 22 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 1.90365282594083e-08 1.67215924155173e-07 2.54064981670101 0.740740740740741 22.4 22 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 4.18222765546385e-05 0.000206642706726564 2.515243318534 0.733333333333333 22.4 22 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 6.28969714142327e-08 5.39171026038874e-07 2.50644876147618 0.730769230769231 22.4 22 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 8.04809581401171e-07 5.4276968451842e-06 2.49445618367008 0.727272727272727 22.4 22 4 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000568344542947819 0.00201182657864365 2.49445618367008 0.727272727272727 22.4 22 4 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.000568344542947819 0.00201182657864365 2.49445618367008 0.727272727272727 22.4 22 4 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.000568344542947819 0.00201182657864365 2.49445618367008 0.727272727272727 22.4 22 4 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.000568344542947819 0.00201182657864365 2.49445618367008 0.727272727272727 22.4 22 4 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.000568344542947819 0.00201182657864365 2.49445618367008 0.727272727272727 22.4 22 4 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.000568344542947819 0.00201182657864365 2.49445618367008 0.727272727272727 22.4 22 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.61405218151856e-06 1.61030140878827e-05 2.4499123232474 0.714285714285714 22.4 22 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000137228688729629 0.000570983696088487 2.4499123232474 0.714285714285714 22.4 22 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000137228688729629 0.000570983696088487 2.4499123232474 0.714285714285714 22.4 22 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000137228688729629 0.000570983696088487 2.4499123232474 0.714285714285714 22.4 22 4 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.00812031996847547 0.0203079355274879 2.4499123232474 0.714285714285714 22.4 22 4 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.00812031996847547 0.0203079355274879 2.4499123232474 0.714285714285714 22.4 22 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 6.59366842916476e-07 4.51095681476032e-06 2.42949638722034 0.708333333333333 22.4 22 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 3.36551661412034e-05 0.0001674521028634 2.42108982532684 0.705882352941177 22.4 22 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 3.36551661412034e-05 0.0001674521028634 2.42108982532684 0.705882352941177 22.4 22 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 3.36551661412034e-05 0.0001674521028634 2.42108982532684 0.705882352941177 22.4 22 4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 3.36551661412034e-05 0.0001674521028634 2.42108982532684 0.705882352941177 22.4 22 4 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.00185481743033501 0.00570065918653718 2.40091407678245 0.7 22.4 22 4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00185481743033501 0.00570065918653718 2.40091407678245 0.7 22.4 22 4 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00185481743033501 0.00570065918653718 2.40091407678245 0.7 22.4 22 4 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00185481743033501 0.00570065918653718 2.40091407678245 0.7 22.4 22 4 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00185481743033501 0.00570065918653718 2.40091407678245 0.7 22.4 22 4 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.00185481743033501 0.00570065918653718 2.40091407678245 0.7 22.4 22 4 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00185481743033501 0.00570065918653718 2.40091407678245 0.7 22.4 22 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.23143931487454e-16 5.3101155911105e-15 2.38600156698877 0.695652173913043 22.4 22 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 5.25083567277821e-07 3.66271527566833e-06 2.37453040560902 0.692307692307692 22.4 22 4 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000439343945332167 0.00161546882224205 2.37453040560902 0.692307692307692 22.4 22 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 3.37217499112253e-08 2.936617980727e-07 2.35804061112562 0.6875 22.4 22 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000106377548634115 0.000449184723164232 2.35804061112562 0.6875 22.4 22 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000106377548634115 0.000449184723164232 2.35804061112562 0.6875 22.4 22 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 2.613913826954e-05 0.000136749977049836 2.3467581201633 0.684210526315789 22.4 22 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 6.4910006103415e-06 3.80110858786665e-05 2.3385526721907 0.681818181818182 22.4 22 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.6246663917941e-06 1.05086376160136e-05 2.33231653173152 0.68 22.4 22 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.24111965401958e-06 8.17645031328643e-06 2.2865848350309 0.666666666666667 22.4 22 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 1.98092618338451e-05 0.000105575204455287 2.2865848350309 0.666666666666667 22.4 22 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.98092618338451e-05 0.000105575204455287 2.2865848350309 0.666666666666667 22.4 22 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 8.01246119866828e-05 0.000365440137362339 2.2865848350309 0.666666666666667 22.4 22 4 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00032804151307961 0.00124813655912376 2.2865848350309 0.666666666666667 22.4 22 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00032804151307961 0.00124813655912376 2.2865848350309 0.666666666666667 22.4 22 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00032804151307961 0.00124813655912376 2.2865848350309 0.666666666666667 22.4 22 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00032804151307961 0.00124813655912376 2.2865848350309 0.666666666666667 22.4 22 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00032804151307961 0.00124813655912376 2.2865848350309 0.666666666666667 22.4 22 4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00136649602376191 0.00436971649845663 2.2865848350309 0.666666666666667 22.4 22 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00136649602376191 0.00436971649845663 2.2865848350309 0.666666666666667 22.4 22 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00584601045856218 0.0152360309203919 2.2865848350309 0.666666666666667 22.4 22 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 9.34210017912598e-07 6.24122467366022e-06 2.24716095856485 0.655172413793103 22.4 22 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 3.70165617143593e-06 2.19477363831389e-05 2.24261204974185 0.653846153846154 22.4 22 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 3.70165617143593e-06 2.19477363831389e-05 2.24261204974185 0.653846153846154 22.4 22 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.15739651859967e-08 1.07645440912898e-07 2.22942021415513 0.65 22.4 22 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 5.91839302672826e-05 0.000273437444059555 2.22942021415513 0.65 22.4 22 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 5.91839302672826e-05 0.000273437444059555 2.22942021415513 0.65 22.4 22 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 5.72992815299084e-10 6.79473980142163e-09 2.21512905893619 0.645833333333333 22.4 22 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.86231237900747e-11 3.9932063875761e-10 2.20492109092266 0.642857142857143 22.4 22 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000983151407216734 0.00320877167997572 2.20492109092266 0.642857142857143 22.4 22 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000983151407216734 0.00320877167997572 2.20492109092266 0.642857142857143 22.4 22 4 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000983151407216734 0.00320877167997572 2.20492109092266 0.642857142857143 22.4 22 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000983151407216734 0.00320877167997572 2.20492109092266 0.642857142857143 22.4 22 4 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000983151407216734 0.00320877167997572 2.20492109092266 0.642857142857143 22.4 22 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.0837945185314e-05 6.09580869513905e-05 2.19512144162967 0.64 22.4 22 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 1.0837945185314e-05 6.09580869513905e-05 2.19512144162967 0.64 22.4 22 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.31072182523198e-07 1.01921156136891e-06 2.19131046690462 0.638888888888889 22.4 22 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 4.31162189749765e-05 0.000210330703097359 2.18264916071132 0.636363636363636 22.4 22 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 4.31162189749765e-05 0.000210330703097359 2.18264916071132 0.636363636363636 22.4 22 4 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00410614498326258 0.0111084492608035 2.18264916071132 0.636363636363636 22.4 22 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00410614498326258 0.0111084492608035 2.18264916071132 0.636363636363636 22.4 22 4 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00410614498326258 0.0111084492608035 2.18264916071132 0.636363636363636 22.4 22 4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00410614498326258 0.0111084492608035 2.18264916071132 0.636363636363636 22.4 22 4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00410614498326258 0.0111084492608035 2.18264916071132 0.636363636363636 22.4 22 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00410614498326258 0.0111084492608035 2.18264916071132 0.636363636363636 22.4 22 4 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00410614498326258 0.0111084492608035 2.18264916071132 0.636363636363636 22.4 22 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.00649737985718e-06 1.24141120501598e-05 2.17225559327936 0.633333333333333 22.4 22 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 3.74536601943971e-07 2.66482792283135e-06 2.15592284445771 0.628571428571429 22.4 22 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.97808642589974e-10 1.03030782129478e-08 2.15207984473497 0.627450980392157 22.4 22 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.97808642589974e-10 1.03030782129478e-08 2.15207984473497 0.627450980392157 22.4 22 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.24379643413905e-12 4.20121358655245e-11 2.15007230756637 0.626865671641791 22.4 22 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 3.10949593446923e-05 0.000160902280536353 2.14367328284147 0.625 22.4 22 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000697481453822103 0.00239160508141892 2.14367328284147 0.625 22.4 22 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000697481453822103 0.00239160508141892 2.14367328284147 0.625 22.4 22 4 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.000697481453822103 0.00239160508141892 2.14367328284147 0.625 22.4 22 4 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0176375790418911 0.0384353368707673 2.14367328284147 0.625 22.4 22 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0176375790418911 0.0384353368707673 2.14367328284147 0.625 22.4 22 4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0176375790418911 0.0384353368707673 2.14367328284147 0.625 22.4 22 4 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0176375790418911 0.0384353368707673 2.14367328284147 0.625 22.4 22 4 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0176375790418911 0.0384353368707673 2.14367328284147 0.625 22.4 22 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.2786493103007e-11 4.48607496976721e-10 2.13664484584855 0.622950819672131 22.4 22 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.2786493103007e-11 4.48607496976721e-10 2.13664484584855 0.622950819672131 22.4 22 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.39457748409358e-11 3.40748375986517e-10 2.12325734681441 0.619047619047619 22.4 22 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 2.22560076075188e-05 0.000117297403057405 2.11069369387468 0.615384615384615 22.4 22 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 2.22560076075188e-05 0.000117297403057405 2.11069369387468 0.615384615384615 22.4 22 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 2.22560076075188e-05 0.000117297403057405 2.11069369387468 0.615384615384615 22.4 22 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00284993934924949 0.00803917831436823 2.11069369387468 0.615384615384615 22.4 22 4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00284993934924949 0.00803917831436823 2.11069369387468 0.615384615384615 22.4 22 4 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00284993934924949 0.00803917831436823 2.11069369387468 0.615384615384615 22.4 22 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 3.33601538116975e-12 5.9339373592557e-11 2.10692459799276 0.614285714285714 22.4 22 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.39439094078974e-13 1.28158004348504e-11 2.10365804822843 0.613333333333333 22.4 22 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.39439094078974e-13 1.28158004348504e-11 2.10365804822843 0.613333333333333 22.4 22 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.39439094078974e-13 1.28158004348504e-11 2.10365804822843 0.613333333333333 22.4 22 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.39439094078974e-13 1.28158004348504e-11 2.10365804822843 0.613333333333333 22.4 22 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.39439094078974e-13 1.28158004348504e-11 2.10365804822843 0.613333333333333 22.4 22 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.3576687386074e-14 6.84686247967006e-13 2.09827784861659 0.611764705882353 22.4 22 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.3576687386074e-14 6.84686247967006e-13 2.09827784861659 0.611764705882353 22.4 22 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.3576687386074e-14 6.84686247967006e-13 2.09827784861659 0.611764705882353 22.4 22 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 7.57123546748046e-07 5.15496079915057e-06 2.09603609877833 0.611111111111111 22.4 22 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000490466252260952 0.00177591215513317 2.09603609877833 0.611111111111111 22.4 22 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000490466252260952 0.00177591215513317 2.09603609877833 0.611111111111111 22.4 22 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000490466252260952 0.00177591215513317 2.09603609877833 0.611111111111111 22.4 22 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 8.72429823041156e-05 0.000372510782065213 2.08775137111517 0.608695652173913 22.4 22 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.58373143191563e-05 8.53655237733314e-05 2.08242547476029 0.607142857142857 22.4 22 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.81346407507711e-10 2.28368086622542e-09 2.08041734990517 0.60655737704918 22.4 22 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 2.91467618040128e-06 1.78007905781589e-05 2.07871348639173 0.606060606060606 22.4 22 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 5.41709487069288e-07 3.76025658585169e-06 2.07597833706753 0.605263157894737 22.4 22 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.6115313507613e-09 3.64482915754137e-08 2.07086928455629 0.60377358490566 22.4 22 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 6.85466105148596e-10 8.06130799691283e-09 2.06975351446763 0.603448275862069 22.4 22 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 4.7594262882734e-12 8.25934586367445e-11 2.06732327550739 0.602739726027397 22.4 22 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 6.44607878530679e-15 2.08472047988444e-13 2.06530243164082 0.602150537634409 22.4 22 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.41404793006333e-14 6.87038040896025e-13 2.05792635152781 0.6 22.4 22 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.25709679087351e-13 3.03194700578476e-12 2.05792635152781 0.6 22.4 22 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 4.91589068164103e-10 5.8784138151052e-09 2.05792635152781 0.6 22.4 22 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 2.58736235750291e-09 2.727271581279e-08 2.05792635152781 0.6 22.4 22 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 2.58736235750291e-09 2.727271581279e-08 2.05792635152781 0.6 22.4 22 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 7.24506232095484e-08 6.13674028733258e-07 2.05792635152781 0.6 22.4 22 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.12188353012757e-05 6.28519788728949e-05 2.05792635152781 0.6 22.4 22 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 6.14804805837601e-05 0.000283128556215827 2.05792635152781 0.6 22.4 22 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000342901950496395 0.00129087162845601 2.05792635152781 0.6 22.4 22 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000342901950496395 0.00129087162845601 2.05792635152781 0.6 22.4 22 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000342901950496395 0.00129087162845601 2.05792635152781 0.6 22.4 22 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000342901950496395 0.00129087162845601 2.05792635152781 0.6 22.4 22 4 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00196581624842242 0.00593918582060531 2.05792635152781 0.6 22.4 22 4 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00196581624842242 0.00593918582060531 2.05792635152781 0.6 22.4 22 4 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00196581624842242 0.00593918582060531 2.05792635152781 0.6 22.4 22 4 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0118328000009029 0.0271144515318597 2.05792635152781 0.6 22.4 22 4 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0118328000009029 0.0271144515318597 2.05792635152781 0.6 22.4 22 4 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0118328000009029 0.0271144515318597 2.05792635152781 0.6 22.4 22 4 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0118328000009029 0.0271144515318597 2.05792635152781 0.6 22.4 22 4 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0118328000009029 0.0271144515318597 2.05792635152781 0.6 22.4 22 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 5.16081848140961e-08 4.45081496911871e-07 2.04333112917655 0.595744680851064 22.4 22 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.75680999781185e-12 3.33325416918167e-11 2.04055988442631 0.594936708860759 22.4 22 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.75680999781185e-12 3.33325416918167e-11 2.04055988442631 0.594936708860759 22.4 22 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.79449426758531e-11 6.20233212979446e-10 2.03804300513624 0.594202898550725 22.4 22 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.79449426758531e-11 6.20233212979446e-10 2.03804300513624 0.594202898550725 22.4 22 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.31851212683929e-09 1.44326365884024e-08 2.0346729464258 0.593220338983051 22.4 22 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 6.94161067508614e-09 6.85966110461638e-08 2.0325198533608 0.592592592592593 22.4 22 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 4.31599193987553e-05 0.000210330703097359 2.0325198533608 0.592592592592593 22.4 22 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.25582690269163e-12 2.44800230483587e-11 2.0325198533608 0.592592592592593 22.4 22 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.25582690269163e-12 2.44800230483587e-11 2.0325198533608 0.592592592592593 22.4 22 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.94547886668903e-07 1.42701877695798e-06 2.02674564923194 0.590909090909091 22.4 22 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 4.93182044453634e-09 4.90767866613651e-08 2.0211776666791 0.589285714285714 22.4 22 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 6.38841662539746e-13 1.28158004348504e-11 2.01757485443903 0.588235294117647 22.4 22 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00135145222137112 0.00434112079235012 2.01757485443903 0.588235294117647 22.4 22 4 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00135145222137112 0.00434112079235012 2.01757485443903 0.588235294117647 22.4 22 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000165850214447307 0.000684072043937734 2.00076173065204 0.583333333333333 22.4 22 4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00794165352656351 0.0199311692562608 2.00076173065204 0.583333333333333 22.4 22 4 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00794165352656351 0.0199311692562608 2.00076173065204 0.583333333333333 22.4 22 4 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00794165352656351 0.0199311692562608 2.00076173065204 0.583333333333333 22.4 22 4 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00794165352656351 0.0199311692562608 2.00076173065204 0.583333333333333 22.4 22 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00794165352656351 0.0199311692562608 2.00076173065204 0.583333333333333 22.4 22 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 8.73204076881216e-12 1.38063266822441e-10 1.99714371667256 0.582278481012658 22.4 22 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.29996952908539e-08 1.17079534170159e-07 1.99556494693606 0.581818181818182 22.4 22 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.29996952908539e-08 1.17079534170159e-07 1.99556494693606 0.581818181818182 22.4 22 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.29996952908539e-08 1.17079534170159e-07 1.99556494693606 0.581818181818182 22.4 22 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.29996952908539e-08 1.17079534170159e-07 1.99556494693606 0.581818181818182 22.4 22 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 2.74267497003274e-06 1.68225279411922e-05 1.98571840936894 0.578947368421053 22.4 22 4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000927434533876236 0.00309797967536592 1.98571840936894 0.578947368421053 22.4 22 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.23592234358902e-09 1.36334689529238e-08 1.98289778662836 0.578125 22.4 22 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.23592234358902e-09 1.36334689529238e-08 1.98289778662836 0.578125 22.4 22 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000114968398278634 0.000484023759616854 1.97877533800751 0.576923076923077 22.4 22 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 3.3844367451808e-08 2.936617980727e-07 1.96900360794328 0.574074074074074 22.4 22 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.77730844781385e-07 1.33111048486269e-06 1.95992985859792 0.571428571428571 22.4 22 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000635880862529431 0.00221779036122397 1.95992985859792 0.571428571428571 22.4 22 4 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00533898993862651 0.0142273083945047 1.95992985859792 0.571428571428571 22.4 22 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.19585046896529e-09 3.24835372666972e-08 1.95992985859792 0.571428571428571 22.4 22 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 5.61780183205949e-12 9.51682381788172e-11 1.95423238807874 0.569767441860465 22.4 22 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.13371712309814e-10 2.61748229842126e-09 1.94668708928307 0.567567567567568 22.4 22 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.13371712309814e-10 2.61748229842126e-09 1.94668708928307 0.567567567567568 22.4 22 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 7.12252089469108e-06 4.12005985087212e-05 1.94668708928307 0.567567567567568 22.4 22 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 7.12252089469108e-06 4.12005985087212e-05 1.94668708928307 0.567567567567568 22.4 22 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.16715601204343e-08 1.0784824708687e-07 1.94359710977627 0.566666666666667 22.4 22 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 8.69777562067772e-08 7.09935307512344e-07 1.94143995427152 0.566037735849057 22.4 22 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 6.64941738758669e-17 4.73106047126793e-15 1.94093829020065 0.565891472868217 22.4 22 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.4977936735239e-10 1.90300035484331e-09 1.94058844551965 0.565789473684211 22.4 22 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 6.52872551439129e-07 4.48810454443421e-06 1.93862627317838 0.565217391304348 22.4 22 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 6.52872551439129e-07 4.48810454443421e-06 1.93862627317838 0.565217391304348 22.4 22 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000435819015905993 0.00160665922185033 1.93862627317838 0.565217391304348 22.4 22 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 8.17065425850195e-09 8.01851104127467e-08 1.93622102966327 0.564516129032258 22.4 22 4 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00359653241290855 0.0099376031525609 1.92930595455733 0.5625 22.4 22 4 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00359653241290855 0.0099376031525609 1.92930595455733 0.5625 22.4 22 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00359653241290855 0.0099376031525609 1.92930595455733 0.5625 22.4 22 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00359653241290855 0.0099376031525609 1.92930595455733 0.5625 22.4 22 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.43653715027773e-06 2.08093292121073e-05 1.92407748313576 0.560975609756098 22.4 22 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 3.1682426430673e-07 2.28853262999227e-06 1.92073126142596 0.56 22.4 22 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.000298684421182732 0.00115811425434068 1.92073126142596 0.56 22.4 22 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000298684421182732 0.00115811425434068 1.92073126142596 0.56 22.4 22 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000298684421182732 0.00115811425434068 1.92073126142596 0.56 22.4 22 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.52908161952386e-11 3.56325063820044e-10 1.91435009444448 0.558139534883721 22.4 22 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.42192068110632e-12 4.36252294837253e-11 1.91351046721007 0.557894736842105 22.4 22 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.3257022011708e-13 5.33786166494524e-12 1.91281616007393 0.557692307692308 22.4 22 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.3257022011708e-13 5.33786166494524e-12 1.91281616007393 0.557692307692308 22.4 22 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 2.2050605145452e-07 1.60912877548606e-06 1.91281616007393 0.557692307692308 22.4 22 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.85293629897915e-10 2.31291960828713e-09 1.91031138116506 0.556962025316456 22.4 22 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.76924728814368e-11 2.65014620108259e-10 1.9098180156224 0.556818181818182 22.4 22 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.13995269222574e-13 2.79681496730556e-12 1.90548736252575 0.555555555555556 22.4 22 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000204728996878483 0.000811502402668749 1.90548736252575 0.555555555555556 22.4 22 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00242768468275884 0.00705019449707311 1.90548736252575 0.555555555555556 22.4 22 4 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00242768468275884 0.00705019449707311 1.90548736252575 0.555555555555556 22.4 22 4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00242768468275884 0.00705019449707311 1.90548736252575 0.555555555555556 22.4 22 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00242768468275884 0.00705019449707311 1.90548736252575 0.555555555555556 22.4 22 4 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0323770397710523 0.0655370236048469 1.90548736252575 0.555555555555556 22.4 22 4 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0323770397710523 0.0655370236048469 1.90548736252575 0.555555555555556 22.4 22 4 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0323770397710523 0.0655370236048469 1.90548736252575 0.555555555555556 22.4 22 4 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0323770397710523 0.0655370236048469 1.90548736252575 0.555555555555556 22.4 22 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.43891589954228e-08 1.27973582815541e-07 1.90548736252575 0.555555555555556 22.4 22 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.6543130396518e-06 1.065197943631e-05 1.90548736252575 0.555555555555556 22.4 22 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.14711629627741e-06 7.62778733459233e-06 1.89737890566394 0.553191489361702 22.4 22 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.40583854993873e-11 5.91463043071964e-10 1.8923460703704 0.551724137931034 22.4 22 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 7.41417897005246e-08 6.24282643454713e-07 1.8923460703704 0.551724137931034 22.4 22 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.66348924440266e-19 5.37276346318999e-17 1.8864324889005 0.55 22.4 22 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 8.65247276714364e-06 4.92498749905816e-05 1.8864324889005 0.55 22.4 22 4 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00164186324689604 0.00514619251174684 1.8864324889005 0.55 22.4 22 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00164186324689604 0.00514619251174684 1.8864324889005 0.55 22.4 22 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00164186324689604 0.00514619251174684 1.8864324889005 0.55 22.4 22 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00164186324689604 0.00514619251174684 1.8864324889005 0.55 22.4 22 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.04198860763355e-11 1.61168455289407e-10 1.87740649613064 0.547368421052632 22.4 22 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.04198860763355e-11 1.61168455289407e-10 1.87740649613064 0.547368421052632 22.4 22 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0211047860220713 0.0451610684351992 1.87084213775256 0.545454545454545 22.4 22 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0211047860220713 0.0451610684351992 1.87084213775256 0.545454545454545 22.4 22 4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0211047860220713 0.0451610684351992 1.87084213775256 0.545454545454545 22.4 22 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0211047860220713 0.0451610684351992 1.87084213775256 0.545454545454545 22.4 22 4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0211047860220713 0.0451610684351992 1.87084213775256 0.545454545454545 22.4 22 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 7.73534303042681e-15 2.44608736273274e-13 1.86347661752519 0.543307086614173 22.4 22 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00075487305399353 0.00257598166866377 1.85785017846261 0.541666666666667 22.4 22 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 8.5840090664386e-12 1.37247695522945e-10 1.85213371637503 0.54 22.4 22 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.35673803195448e-06 8.89695032014389e-06 1.85213371637503 0.54 22.4 22 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.77970449736141e-09 2.90847022040095e-08 1.85032851782106 0.539473684210526 22.4 22 4 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.000513019781237512 0.00185286078350503 1.84685698214035 0.538461538461538 22.4 22 4 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0138819867334299 0.031305970081887 1.84685698214035 0.538461538461538 22.4 22 4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0138819867334299 0.031305970081887 1.84685698214035 0.538461538461538 22.4 22 4 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0138819867334299 0.031305970081887 1.84685698214035 0.538461538461538 22.4 22 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 9.28119383040781e-10 1.05657110565363e-08 1.84042194039073 0.536585365853659 22.4 22 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000349120078463401 0.00130736282014058 1.83743424243555 0.535714285714286 22.4 22 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000349120078463401 0.00130736282014058 1.83743424243555 0.535714285714286 22.4 22 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.40001593130507e-08 1.25297023285982e-07 1.83570895206706 0.535211267605634 22.4 22 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.76999818030319e-22 3.0320826235165e-20 1.82926786802472 0.533333333333333 22.4 22 4 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00023787172536601 0.000935059296121082 1.82926786802472 0.533333333333333 22.4 22 4 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00919404558457405 0.022252792362246 1.82926786802472 0.533333333333333 22.4 22 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00919404558457405 0.022252792362246 1.82926786802472 0.533333333333333 22.4 22 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00919404558457405 0.022252792362246 1.82926786802472 0.533333333333333 22.4 22 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00919404558457405 0.022252792362246 1.82926786802472 0.533333333333333 22.4 22 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00919404558457405 0.022252792362246 1.82926786802472 0.533333333333333 22.4 22 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00919404558457405 0.022252792362246 1.82926786802472 0.533333333333333 22.4 22 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.08816804703768e-13 2.71660198409582e-12 1.82557982796822 0.532258064516129 22.4 22 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.08816804703768e-13 2.71660198409582e-12 1.82557982796822 0.532258064516129 22.4 22 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.08816804703768e-13 2.71660198409582e-12 1.82557982796822 0.532258064516129 22.4 22 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.472163889481e-07 1.12628452404917e-06 1.82557982796822 0.532258064516129 22.4 22 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.77762659792329e-06 2.82098035221778e-05 1.82440279390764 0.531914893617021 22.4 22 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.32050392811661e-12 4.2334321662948e-11 1.82308790901113 0.531531531531532 22.4 22 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.01708048349722e-07 8.08550574310916e-07 1.82212229041525 0.53125 22.4 22 4 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00612224762838814 0.0157825332883991 1.81581736899513 0.529411764705882 22.4 22 4 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00612224762838814 0.0157825332883991 1.81581736899513 0.529411764705882 22.4 22 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 5.15477484523705e-23 6.66840418615666e-21 1.81491262690794 0.52914798206278 22.4 22 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.59114299628091e-13 5.85269283128212e-12 1.81253675947572 0.528455284552846 22.4 22 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 7.57113074379962e-05 0.000346421834354561 1.81021299439947 0.527777777777778 22.4 22 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 5.51826994464795e-12 9.46084112196872e-11 1.80848073316081 0.527272727272727 22.4 22 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00409462929262838 0.0111084492608035 1.80519855397177 0.526315789473684 22.4 22 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00409462929262838 0.0111084492608035 1.80519855397177 0.526315789473684 22.4 22 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.19327536275684e-16 8.91723097486567e-15 1.80177096178068 0.525316455696203 22.4 22 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 3.54486711484417e-05 0.00017576118133879 1.80068555758684 0.525 22.4 22 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00274844386969931 0.00785348519393999 1.79660237038142 0.523809523809524 22.4 22 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00274844386969931 0.00785348519393999 1.79660237038142 0.523809523809524 22.4 22 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00274844386969931 0.00785348519393999 1.79660237038142 0.523809523809524 22.4 22 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.87962152371789e-11 2.78614732109433e-10 1.79507594525791 0.523364485981308 22.4 22 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.4146862543464e-13 3.35516423322487e-12 1.79408963979348 0.523076923076923 22.4 22 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.30190737680845e-11 1.99205827655744e-10 1.79360553573525 0.522935779816514 22.4 22 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.15204658831991e-07 9.0074851383474e-07 1.79172692297198 0.522388059701492 22.4 22 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 5.15660126602728e-16 1.88149835937354e-14 1.79140085801784 0.522292993630573 22.4 22 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.5755147427708e-16 1.37512364296293e-14 1.79043906893929 0.522012578616352 22.4 22 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 7.94814702570864e-08 6.61415977636456e-07 1.78950117524158 0.521739130434783 22.4 22 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.14163977418814e-05 6.32121945007675e-05 1.78950117524158 0.521739130434783 22.4 22 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.14163977418814e-05 6.32121945007675e-05 1.78950117524158 0.521739130434783 22.4 22 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00185044770348193 0.00570065918653718 1.78950117524158 0.521739130434783 22.4 22 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00185044770348193 0.00570065918653718 1.78950117524158 0.521739130434783 22.4 22 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00124907740620523 0.00403962988415919 1.78353617132411 0.52 22.4 22 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000845025241316467 0.00284945715259084 1.7784548716907 0.518518518518518 22.4 22 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000845025241316467 0.00284945715259084 1.7784548716907 0.518518518518518 22.4 22 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000845025241316467 0.00284945715259084 1.7784548716907 0.518518518518518 22.4 22 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000845025241316467 0.00284945715259084 1.7784548716907 0.518518518518518 22.4 22 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000845025241316467 0.00284945715259084 1.7784548716907 0.518518518518518 22.4 22 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.83625962213551e-09 2.92463582775277e-08 1.77407444097225 0.517241379310345 22.4 22 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.83625962213551e-09 2.92463582775277e-08 1.77407444097225 0.517241379310345 22.4 22 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000572786532608365 0.00201751296015273 1.77407444097225 0.517241379310345 22.4 22 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000572786532608365 0.00201751296015273 1.77407444097225 0.517241379310345 22.4 22 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.31935537507809e-12 4.2334321662948e-11 1.77116612221656 0.516393442622951 22.4 22 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.80128454336278e-15 9.27029745396566e-14 1.7702592271207 0.516129032258065 22.4 22 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 8.83053755654848e-08 7.09935307512344e-07 1.76257581033632 0.513888888888889 22.4 22 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 8.83053755654848e-08 7.09935307512344e-07 1.76257581033632 0.513888888888889 22.4 22 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 8.83053755654848e-08 7.09935307512344e-07 1.76257581033632 0.513888888888889 22.4 22 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 8.83053755654848e-08 7.09935307512344e-07 1.76257581033632 0.513888888888889 22.4 22 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 8.37915495105536e-05 0.000372510782065213 1.75891141156223 0.512820512820513 22.4 22 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 5.72431998304043e-05 0.000266199586139429 1.7567663976457 0.51219512195122 22.4 22 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 5.72431998304043e-05 0.000266199586139429 1.7567663976457 0.51219512195122 22.4 22 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 5.72431998304043e-05 0.000266199586139429 1.7567663976457 0.51219512195122 22.4 22 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 5.72431998304043e-05 0.000266199586139429 1.7567663976457 0.51219512195122 22.4 22 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 5.72431998304043e-05 0.000266199586139429 1.7567663976457 0.51219512195122 22.4 22 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 9.51775816956776e-09 9.01923711018888e-08 1.7557704983273 0.511904761904762 22.4 22 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 9.51775816956776e-09 9.01923711018888e-08 1.7557704983273 0.511904761904762 22.4 22 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 5.88575536154536e-13 1.28158004348504e-11 1.75362145242972 0.511278195488722 22.4 22 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.22167705337832e-23 3.16144644695735e-21 1.74132229744661 0.507692307692308 22.4 22 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.29094154268294e-07 3.03781582847653e-06 1.74053472517278 0.507462686567164 22.4 22 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.43690075666207e-24 4.33463722091266e-22 1.74015831195367 0.507352941176471 22.4 22 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.40158771548538e-07 1.07808611845172e-06 1.73843093622213 0.506849315068493 22.4 22 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.39069512769419e-14 9.27876762828621e-13 1.73750360819783 0.506578947368421 22.4 22 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.93407380012164e-11 2.80835409956439e-10 1.7291116727713 0.504132231404959 22.4 22 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.93407380012164e-11 2.80835409956439e-10 1.7291116727713 0.504132231404959 22.4 22 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.24159278343194e-22 1.47232210901971e-20 1.72150927235085 0.501915708812261 22.4 22 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 9.29003977734718e-06 5.26682334787452e-05 1.71493862627318 0.5 22.4 22 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00198513503117295 0.00597219270477611 1.71493862627318 0.5 22.4 22 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00198513503117295 0.00597219270477611 1.71493862627318 0.5 22.4 22 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.32138718484607e-10 1.69399456219455e-09 1.71493862627318 0.5 22.4 22 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.0417427208865e-07 8.19005465094744e-07 1.71493862627318 0.5 22.4 22 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.97628535058319e-05 0.000105575204455287 1.71493862627318 0.5 22.4 22 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 4.21546963755211e-05 0.000207564473849019 1.71493862627318 0.5 22.4 22 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000132134427872665 0.000554652775406497 1.71493862627318 0.5 22.4 22 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000284458611414097 0.00111204561550071 1.71493862627318 0.5 22.4 22 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000907701339850716 0.00303919766260604 1.71493862627318 0.5 22.4 22 4 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00134093040416954 0.00432685706379421 1.71493862627318 0.5 22.4 22 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00294602235297032 0.00828496009540864 1.71493862627318 0.5 22.4 22 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00438450717726066 0.0117942414238978 1.71493862627318 0.5 22.4 22 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00438450717726066 0.0117942414238978 1.71493862627318 0.5 22.4 22 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0147915587562396 0.0329395745072439 1.71493862627318 0.5 22.4 22 4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0147915587562396 0.0329395745072439 1.71493862627318 0.5 22.4 22 4 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0224249835282332 0.0468586660215505 1.71493862627318 0.5 22.4 22 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0224249835282332 0.0468586660215505 1.71493862627318 0.5 22.4 22 4 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0224249835282332 0.0468586660215505 1.71493862627318 0.5 22.4 22 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0224249835282332 0.0468586660215505 1.71493862627318 0.5 22.4 22 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0224249835282332 0.0468586660215505 1.71493862627318 0.5 22.4 22 4 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0342679185175791 0.0679153872569848 1.71493862627318 0.5 22.4 22 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0342679185175791 0.0679153872569848 1.71493862627318 0.5 22.4 22 4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0342679185175791 0.0679153872569848 1.71493862627318 0.5 22.4 22 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0342679185175791 0.0679153872569848 1.71493862627318 0.5 22.4 22 4 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0342679185175791 0.0679153872569848 1.71493862627318 0.5 22.4 22 4 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0342679185175791 0.0679153872569848 1.71493862627318 0.5 22.4 22 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0342679185175791 0.0679153872569848 1.71493862627318 0.5 22.4 22 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0342679185175791 0.0679153872569848 1.71493862627318 0.5 22.4 22 4 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0529212795412015 0.0981838080666621 1.71493862627318 0.5 22.4 22 4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0529212795412015 0.0981838080666621 1.71493862627318 0.5 22.4 22 4 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0529212795412015 0.0981838080666621 1.71493862627318 0.5 22.4 22 4 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0529212795412015 0.0981838080666621 1.71493862627318 0.5 22.4 22 4 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0529212795412015 0.0981838080666621 1.71493862627318 0.5 22.4 22 4 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0529212795412015 0.0981838080666621 1.71493862627318 0.5 22.4 22 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.5613088503645e-16 1.37512364296293e-14 1.70576783148027 0.497326203208556 22.4 22 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.241723775883e-15 7.7804217880037e-14 1.70524970748067 0.497175141242938 22.4 22 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 4.67135633804831e-11 6.15494450837291e-10 1.70099603581567 0.495934959349593 22.4 22 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.93753871690176e-09 3.94585746066986e-08 1.69761601388658 0.494949494949495 22.4 22 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.50481306384735e-14 4.65510649968429e-13 1.69476287772879 0.494117647058824 22.4 22 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 7.65253373571592e-08 6.4056208858375e-07 1.69427671511326 0.493975903614458 22.4 22 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 4.9222769044757e-07 3.45044336702903e-06 1.69144631632423 0.493150684931507 22.4 22 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.76114881972199e-12 6.60754909933876e-11 1.6904395030407 0.492857142857143 22.4 22 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.53789355663311e-15 8.59862507402124e-14 1.68682487830149 0.491803278688525 22.4 22 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.39754873864879e-23 2.20967983899692e-21 1.6856734620023 0.491467576791809 22.4 22 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.3294422006735e-14 9.27876762828621e-13 1.68449592876537 0.49112426035503 22.4 22 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.00354912473392e-13 2.64453778610437e-12 1.68337533867306 0.49079754601227 22.4 22 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.04765795240388e-05 0.000158857775321272 1.68131237869919 0.490196078431373 22.4 22 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 8.29999848604494e-12 1.34214748245931e-10 1.67792556239678 0.489208633093525 22.4 22 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 8.29999848604494e-12 1.34214748245931e-10 1.67792556239678 0.489208633093525 22.4 22 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000138945003060076 0.0005764394733367 1.67505633263892 0.488372093023256 22.4 22 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.69533807573434e-07 1.29008881378073e-06 1.67311085490066 0.48780487804878 22.4 22 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 3.30339079438724e-10 3.98366533933309e-09 1.67170487939234 0.487394957983193 22.4 22 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.08926735029462e-09 2.25229351474943e-08 1.66773848059593 0.486238532110092 22.4 22 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.02215000819627e-09 3.09389889328294e-08 1.66685623488234 0.485981308411215 22.4 22 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000642998019525909 0.00223167361411065 1.66594037980823 0.485714285714286 22.4 22 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000642998019525909 0.00223167361411065 1.66594037980823 0.485714285714286 22.4 22 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000946038454607394 0.00315272299978061 1.66297078911339 0.484848484848485 22.4 22 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00139406223364381 0.00443792071247236 1.65961802542566 0.483870967741935 22.4 22 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 6.87355019130726e-32 1.63017698703837e-29 1.6585791409027 0.483568075117371 22.4 22 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 8.42311419673064e-08 6.96865784996959e-07 1.65713170628644 0.48314606741573 22.4 22 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 6.64612741286452e-39 2.36435982712655e-36 1.65625251358702 0.482889733840304 22.4 22 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.76726404778218e-07 1.33059086772171e-06 1.65441138064001 0.482352941176471 22.4 22 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.76726404778218e-07 1.33059086772171e-06 1.65441138064001 0.482352941176471 22.4 22 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 5.66305847032576e-17 4.24133273856503e-15 1.65257722168143 0.481818181818182 22.4 22 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00304380840746826 0.00850950759101637 1.65142238085565 0.481481481481481 22.4 22 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00304380840746826 0.00850950759101637 1.65142238085565 0.481481481481481 22.4 22 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 3.71057767190385e-07 2.65334272719557e-06 1.65142238085565 0.481481481481481 22.4 22 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 4.09547880661279e-11 5.55034889696191e-10 1.64144125657576 0.478571428571429 22.4 22 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000143392795150949 0.000593162638080813 1.64037607730478 0.478260869565217 22.4 22 4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00670739502822448 0.0171357686268643 1.64037607730478 0.478260869565217 22.4 22 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000209529916982652 0.000825930946998098 1.63698687053349 0.477272727272727 22.4 22 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000209529916982652 0.000825930946998098 1.63698687053349 0.477272727272727 22.4 22 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 7.2765763995982e-06 4.19213288122601e-05 1.63578761275288 0.476923076923077 22.4 22 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.64237527001391e-07 1.91841837205601e-06 1.63517403900466 0.476744186046512 22.4 22 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0100009875825984 0.0236402081894311 1.63327488216493 0.476190476190476 22.4 22 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.13448967823924e-15 4.03594703033611e-14 1.63327488216493 0.476190476190476 22.4 22 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 8.02001092499573e-07 5.4276968451842e-06 1.62919169495952 0.475 22.4 22 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000448507721682499 0.00164068505900822 1.62919169495952 0.475 22.4 22 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.95068289567863e-12 1.16362608947655e-10 1.62699305569507 0.474358974358974 22.4 22 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.68261360393001e-06 1.07854016143802e-05 1.62467869857459 0.473684210526316 22.4 22 4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0149667737272676 0.0331740171556103 1.62467869857459 0.473684210526316 22.4 22 4 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0149667737272676 0.0331740171556103 1.62467869857459 0.473684210526316 22.4 22 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0149667737272676 0.0331740171556103 1.62467869857459 0.473684210526316 22.4 22 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.0071343253219e-08 9.42863253245438e-08 1.62139651938555 0.472727272727273 22.4 22 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 4.72111979819546e-05 0.000226964644352437 1.62139651938555 0.472727272727273 22.4 22 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 7.90396261417798e-10 9.21913016391415e-09 1.6204144500219 0.47244094488189 22.4 22 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.53276865106811e-06 2.13013974172454e-05 1.61966425814689 0.472222222222222 22.4 22 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000963796437310161 0.00318209357376418 1.61966425814689 0.472222222222222 22.4 22 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000963796437310161 0.00318209357376418 1.61966425814689 0.472222222222222 22.4 22 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 5.12049723648586e-06 3.01093701137165e-05 1.61694213334328 0.471428571428571 22.4 22 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 7.4234054420071e-06 4.25947820321617e-05 1.61405988355123 0.470588235294118 22.4 22 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00141526860697691 0.00447539383939587 1.61405988355123 0.470588235294118 22.4 22 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00141526860697691 0.00447539383939587 1.61405988355123 0.470588235294118 22.4 22 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00141526860697691 0.00447539383939587 1.61405988355123 0.470588235294118 22.4 22 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0224976130921074 0.0468727722255767 1.61405988355123 0.470588235294118 22.4 22 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0224976130921074 0.0468727722255767 1.61405988355123 0.470588235294118 22.4 22 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 9.12208120122791e-08 7.29254019626253e-07 1.60994238384829 0.469387755102041 22.4 22 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 1.18283472881933e-06 7.82871543772046e-06 1.60907821724397 0.469135802469136 22.4 22 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.36963551029999e-58 3.37199133115689e-55 1.60629998026492 0.468325791855204 22.4 22 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.26513633016651e-05 0.000118940553425349 1.60429742457813 0.467741935483871 22.4 22 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.28712995900666e-05 0.000165871841548457 1.60060938452163 0.466666666666667 22.4 22 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.28712995900666e-05 0.000165871841548457 1.60060938452163 0.466666666666667 22.4 22 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.28712995900666e-05 0.000165871841548457 1.60060938452163 0.466666666666667 22.4 22 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.28712995900666e-05 0.000165871841548457 1.60060938452163 0.466666666666667 22.4 22 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.28712995900666e-05 0.000165871841548457 1.60060938452163 0.466666666666667 22.4 22 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.28712995900666e-05 0.000165871841548457 1.60060938452163 0.466666666666667 22.4 22 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.28712995900666e-05 0.000165871841548457 1.60060938452163 0.466666666666667 22.4 22 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000309765842094677 0.00119457125555752 1.60060938452163 0.466666666666667 22.4 22 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00306425761068054 0.00854987956862432 1.60060938452163 0.466666666666667 22.4 22 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.034002054228935 0.0679153872569848 1.60060938452163 0.466666666666667 22.4 22 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.034002054228935 0.0679153872569848 1.60060938452163 0.466666666666667 22.4 22 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.17678806358639e-09 1.31855859408144e-08 1.59711841530785 0.465648854961832 22.4 22 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.17678806358639e-09 1.31855859408144e-08 1.59711841530785 0.465648854961832 22.4 22 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.77158623026753e-05 0.000227851248512439 1.59666699687503 0.46551724137931 22.4 22 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.77158623026753e-05 0.000227851248512439 1.59666699687503 0.46551724137931 22.4 22 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000452048887402944 0.0016493988891651 1.5952917453704 0.465116279069767 22.4 22 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.50121744236884e-06 4.2868403295144e-05 1.59416830047929 0.464788732394366 22.4 22 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.33213107860657e-07 1.03022963307454e-06 1.59368033956699 0.464646464646465 22.4 22 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00451963601032714 0.0121119435832307 1.59244301011081 0.464285714285714 22.4 22 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.89089588909592e-13 6.42772632841171e-12 1.58989101810743 0.463541666666667 22.4 22 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.53942192686161e-11 2.33042276800432e-10 1.58945531215563 0.463414634146341 22.4 22 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00667868853753682 0.0170931183253865 1.58302027040601 0.461538461538462 22.4 22 4 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0517415743325643 0.0967519845929553 1.58302027040601 0.461538461538462 22.4 22 4 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0517415743325643 0.0967519845929553 1.58302027040601 0.461538461538462 22.4 22 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0517415743325643 0.0967519845929553 1.58302027040601 0.461538461538462 22.4 22 4 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0517415743325643 0.0967519845929553 1.58302027040601 0.461538461538462 22.4 22 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0517415743325643 0.0967519845929553 1.58302027040601 0.461538461538462 22.4 22 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0517415743325643 0.0967519845929553 1.58302027040601 0.461538461538462 22.4 22 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.92874032038081e-07 1.42207123103725e-06 1.57774353617132 0.46 22.4 22 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.92874032038081e-07 1.42207123103725e-06 1.57774353617132 0.46 22.4 22 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.72875307242763e-06 1.07895422020373e-05 1.57370838646245 0.458823529411765 22.4 22 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.72875307242763e-06 1.07895422020373e-05 1.57370838646245 0.458823529411765 22.4 22 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.72875307242763e-06 1.07895422020373e-05 1.57370838646245 0.458823529411765 22.4 22 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.72875307242763e-06 1.07895422020373e-05 1.57370838646245 0.458823529411765 22.4 22 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.72875307242763e-06 1.07895422020373e-05 1.57370838646245 0.458823529411765 22.4 22 4 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00989009498420877 0.023416980303709 1.57202707408375 0.458333333333333 22.4 22 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00989009498420877 0.023416980303709 1.57202707408375 0.458333333333333 22.4 22 4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00989009498420877 0.023416980303709 1.57202707408375 0.458333333333333 22.4 22 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00989009498420877 0.023416980303709 1.57202707408375 0.458333333333333 22.4 22 4 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00989009498420877 0.023416980303709 1.57202707408375 0.458333333333333 22.4 22 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.5689196666064e-05 8.4888695269236e-05 1.56794388687833 0.457142857142857 22.4 22 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00206560173325144 0.00618810792929853 1.56794388687833 0.457142857142857 22.4 22 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00206560173325144 0.00618810792929853 1.56794388687833 0.457142857142857 22.4 22 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 3.59517215787968e-06 2.15862024500539e-05 1.56673405363229 0.45679012345679 22.4 22 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 8.2975542381609e-07 5.56953758533158e-06 1.56581352833638 0.456521739130435 22.4 22 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.72029854174096e-06 1.07895422020373e-05 1.5590351147938 0.454545454545455 22.4 22 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00302672393072348 0.00849512456295762 1.5590351147938 0.454545454545455 22.4 22 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0146813879203798 0.0327968838472536 1.5590351147938 0.454545454545455 22.4 22 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0146813879203798 0.0327968838472536 1.5590351147938 0.454545454545455 22.4 22 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0794350241404767 0.141207864779027 1.5590351147938 0.454545454545455 22.4 22 4 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0794350241404767 0.141207864779027 1.5590351147938 0.454545454545455 22.4 22 4 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0794350241404767 0.141207864779027 1.5590351147938 0.454545454545455 22.4 22 4 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0794350241404767 0.141207864779027 1.5590351147938 0.454545454545455 22.4 22 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0794350241404767 0.141207864779027 1.5590351147938 0.454545454545455 22.4 22 4 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0794350241404767 0.141207864779027 1.5590351147938 0.454545454545455 22.4 22 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 7.48505773697372e-12 1.23851594880391e-10 1.55562738776693 0.453551912568306 22.4 22 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.08777930844564e-31 2.21129993702593e-29 1.55436384853224 0.453183520599251 22.4 22 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.75698679144553e-14 1.27720607626924e-12 1.55344216370934 0.452914798206278 22.4 22 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000952344812950845 0.00315894328398381 1.55161113805669 0.452380952380952 22.4 22 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000952344812950845 0.00315894328398381 1.55161113805669 0.452380952380952 22.4 22 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00443971262706375 0.0119202095628523 1.54897682373061 0.451612903225806 22.4 22 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000304940255114449 0.00117915756257571 1.54680738840326 0.450980392156863 22.4 22 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.7416226293321e-10 3.33446923208511e-09 1.54344476364586 0.45 22.4 22 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00138711508023047 0.00442570573804475 1.54344476364586 0.45 22.4 22 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0218553560454641 0.0463489890502168 1.54344476364586 0.45 22.4 22 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0218553560454641 0.0463489890502168 1.54344476364586 0.45 22.4 22 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0218553560454641 0.0463489890502168 1.54344476364586 0.45 22.4 22 4 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0218553560454641 0.0463489890502168 1.54344476364586 0.45 22.4 22 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0218553560454641 0.0463489890502168 1.54344476364586 0.45 22.4 22 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000442092702442338 0.00162138638034909 1.53994488889836 0.448979591836735 22.4 22 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00651982521272964 0.0167165968967825 1.53753118217595 0.448275862068966 22.4 22 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 4.6566158456147e-05 0.000224622520281685 1.53576593397598 0.447761194029851 22.4 22 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 4.6566158456147e-05 0.000224622520281685 1.53576593397598 0.447761194029851 22.4 22 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.01947509538637e-16 8.45209723745529e-15 1.53539631521931 0.447653429602888 22.4 22 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.85988649648303e-07 1.38566412800804e-06 1.53119520202962 0.446428571428571 22.4 22 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 6.71190421947486e-05 0.00030809805497783 1.53025292805914 0.446153846153846 22.4 22 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.21596731773664e-18 9.61289718410686e-17 1.52555890067246 0.44478527607362 22.4 22 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00958659264159169 0.0229272627377899 1.5243898900206 0.444444444444444 22.4 22 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0326422551065794 0.0657000410419555 1.5243898900206 0.444444444444444 22.4 22 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0326422551065794 0.0657000410419555 1.5243898900206 0.444444444444444 22.4 22 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0326422551065794 0.0657000410419555 1.5243898900206 0.444444444444444 22.4 22 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0326422551065794 0.0657000410419555 1.5243898900206 0.444444444444444 22.4 22 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 4.55099318963264e-05 0.000221026051496493 1.51894564041339 0.442857142857143 22.4 22 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.000430820324968204 0.00159235668163573 1.51706109247243 0.442307692307692 22.4 22 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000430820324968204 0.00159235668163573 1.51706109247243 0.442307692307692 22.4 22 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000430820324968204 0.00159235668163573 1.51706109247243 0.442307692307692 22.4 22 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.000430820324968204 0.00159235668163573 1.51706109247243 0.442307692307692 22.4 22 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00429892550210236 0.0116079145910658 1.51318114082928 0.441176470588235 22.4 22 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 9.57065919633535e-09 9.01923711018888e-08 1.51106480356937 0.440559440559441 22.4 22 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 3.08190669698485e-05 0.000160056687219322 1.5091459911204 0.44 22.4 22 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.014115400771539 0.0316817275992114 1.5091459911204 0.44 22.4 22 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.014115400771539 0.0316817275992114 1.5091459911204 0.44 22.4 22 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.014115400771539 0.0316817275992114 1.5091459911204 0.44 22.4 22 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 9.40539656777624e-05 0.000399518785550615 1.50706727763401 0.439393939393939 22.4 22 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00195605182005277 0.00593918582060531 1.5057997694106 0.439024390243902 22.4 22 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00195605182005277 0.00593918582060531 1.5057997694106 0.439024390243902 22.4 22 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00195605182005277 0.00593918582060531 1.5057997694106 0.439024390243902 22.4 22 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00195605182005277 0.00593918582060531 1.5057997694106 0.439024390243902 22.4 22 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00195605182005277 0.00593918582060531 1.5057997694106 0.439024390243902 22.4 22 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000899264504844639 0.00301805044904227 1.50057129798903 0.4375 22.4 22 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00627429971072298 0.0161452594726199 1.50057129798903 0.4375 22.4 22 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00283781069376008 0.00803917831436823 1.4950746998279 0.435897435897436 22.4 22 4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0208152286066532 0.0448788944049508 1.49125097936798 0.434782608695652 22.4 22 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0208152286066532 0.0448788944049508 1.49125097936798 0.434782608695652 22.4 22 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00916231808488483 0.022252792362246 1.48628014277009 0.433333333333333 22.4 22 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00916231808488483 0.022252792362246 1.48628014277009 0.433333333333333 22.4 22 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.74340134994947e-05 0.000372510782065213 1.47675270595746 0.430555555555556 22.4 22 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 7.66480142043236e-19 6.41588965957368e-17 1.47649796165766 0.43048128342246 22.4 22 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 4.56508942411615e-11 6.07114229020307e-10 1.46994739394844 0.428571428571429 22.4 22 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 2.93293312555286e-06 1.78357428959903e-05 1.46994739394844 0.428571428571429 22.4 22 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00270883207537921 0.00778720816821136 1.46994739394844 0.428571428571429 22.4 22 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00270883207537921 0.00778720816821136 1.46994739394844 0.428571428571429 22.4 22 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0133868101150401 0.0303334885250034 1.46994739394844 0.428571428571429 22.4 22 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0133868101150401 0.0303334885250034 1.46994739394844 0.428571428571429 22.4 22 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0307461323926134 0.0625919118665078 1.46994739394844 0.428571428571429 22.4 22 4 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0737290174358127 0.134335969028376 1.46994739394844 0.428571428571429 22.4 22 4 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0737290174358127 0.134335969028376 1.46994739394844 0.428571428571429 22.4 22 4 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0737290174358127 0.134335969028376 1.46994739394844 0.428571428571429 22.4 22 4 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0737290174358127 0.134335969028376 1.46994739394844 0.428571428571429 22.4 22 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00597391832874054 0.0155409246467967 1.46994739394844 0.428571428571429 22.4 22 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00866725028545944 0.0215620579654 1.45509944047421 0.424242424242424 22.4 22 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.000546910632389048 0.0019652874492162 1.45333781887558 0.423728813559322 22.4 22 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.000546910632389048 0.0019652874492162 1.45333781887558 0.423728813559322 22.4 22 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00564170132077968 0.0149778749616968 1.44415884317741 0.421052631578947 22.4 22 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0454971506551699 0.0883253006579902 1.44415884317741 0.421052631578947 22.4 22 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0454971506551699 0.0883253006579902 1.44415884317741 0.421052631578947 22.4 22 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.37957731962175e-11 3.40748375986517e-10 1.44260931652164 0.420600858369099 22.4 22 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 1.13478605489993e-05 6.32121945007675e-05 1.44054844606947 0.42 22.4 22 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0125730886933112 0.028672283991317 1.43833562203557 0.419354838709677 22.4 22 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0125730886933112 0.028672283991317 1.43833562203557 0.419354838709677 22.4 22 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0125730886933112 0.028672283991317 1.43833562203557 0.419354838709677 22.4 22 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00368833422676532 0.0101518367595494 1.43576257083336 0.418604651162791 22.4 22 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00241999820262354 0.00705019449707311 1.42911552189432 0.416666666666667 22.4 22 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00241999820262354 0.00705019449707311 1.42911552189432 0.416666666666667 22.4 22 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00241999820262354 0.00705019449707311 1.42911552189432 0.416666666666667 22.4 22 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0286188954798279 0.0586811070141139 1.42911552189432 0.416666666666667 22.4 22 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0286188954798279 0.0586811070141139 1.42911552189432 0.416666666666667 22.4 22 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.111697242442547 0.192427573844726 1.42911552189432 0.416666666666667 22.4 22 4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.111697242442547 0.192427573844726 1.42911552189432 0.416666666666667 22.4 22 4 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.111697242442547 0.192427573844726 1.42911552189432 0.416666666666667 22.4 22 4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.111697242442547 0.192427573844726 1.42911552189432 0.416666666666667 22.4 22 4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.111697242442547 0.192427573844726 1.42911552189432 0.416666666666667 22.4 22 4 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.111697242442547 0.192427573844726 1.42911552189432 0.416666666666667 22.4 22 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.02325344968733e-07 8.08938699391708e-07 1.42001287525805 0.414012738853503 22.4 22 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00105081465344334 0.00340617141651452 1.4192595527778 0.413793103448276 22.4 22 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00105081465344334 0.00340617141651452 1.4192595527778 0.413793103448276 22.4 22 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00105081465344334 0.00340617141651452 1.4192595527778 0.413793103448276 22.4 22 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0182340935754946 0.0396139162716471 1.4192595527778 0.413793103448276 22.4 22 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.65615543652381e-32 4.71341837234675e-30 1.41850237205182 0.413572343149808 22.4 22 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 6.15709136049272e-19 5.47596312873821e-17 1.4150166243689 0.412556053811659 22.4 22 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0117250776338094 0.0270856907027771 1.41230239810732 0.411764705882353 22.4 22 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0117250776338094 0.0270856907027771 1.41230239810732 0.411764705882353 22.4 22 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0674557070386116 0.123538572864793 1.41230239810732 0.411764705882353 22.4 22 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0674557070386116 0.123538572864793 1.41230239810732 0.411764705882353 22.4 22 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0674557070386116 0.123538572864793 1.41230239810732 0.411764705882353 22.4 22 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 1.35523834420081e-05 7.388904842137e-05 1.41041681413121 0.411214953271028 22.4 22 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.30989872335984e-20 2.34784705952933e-18 1.40820163620806 0.410569105691057 22.4 22 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.83456775034574e-06 1.13999559333712e-05 1.40313160331442 0.409090909090909 22.4 22 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00494299021281208 0.013196763738896 1.40313160331442 0.409090909090909 22.4 22 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0418678785656982 0.0815020399438968 1.40313160331442 0.409090909090909 22.4 22 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.48513362079113e-39 1.32468962332373e-36 1.40079070974866 0.408408408408408 22.4 22 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00323231188950435 0.00900113467468628 1.39994989899851 0.408163265306122 22.4 22 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000190417624878615 0.000769398543936404 1.39735739918555 0.407407407407407 22.4 22 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 3.50657161330989e-07 2.52012697259595e-06 1.39407914135755 0.406451612903226 22.4 22 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.01688278641824 0.0371891719398693 1.39338763384696 0.40625 22.4 22 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0108759445725855 0.0254129213904585 1.39049077805933 0.405405405405405 22.4 22 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0108759445725855 0.0254129213904585 1.39049077805933 0.405405405405405 22.4 22 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.000268040754531039 0.00105074929393297 1.38931736812004 0.40506329113924 22.4 22 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.51831246448134e-06 9.9108194355823e-06 1.3865461233698 0.404255319148936 22.4 22 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00279135075463395 0.00796010445660143 1.37195090101854 0.4 22.4 22 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.100213659573731 0.1745459456223 1.37195090101854 0.4 22.4 22 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0142895814759372 0.0320221644728483 1.35389891547883 0.394736842105263 22.4 22 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0222228849045474 0.0467798302058743 1.35116376615463 0.393939393939394 22.4 22 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0222228849045474 0.0467798302058743 1.35116376615463 0.393939393939394 22.4 22 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0222228849045474 0.0467798302058743 1.35116376615463 0.393939393939394 22.4 22 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0222228849045474 0.0467798302058743 1.35116376615463 0.393939393939394 22.4 22 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0222228849045474 0.0467798302058743 1.35116376615463 0.393939393939394 22.4 22 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.034872820338077 0.0690181131308534 1.34745177778607 0.392857142857143 22.4 22 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00849763255196969 0.0211907804574162 1.34212588143118 0.391304347826087 22.4 22 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0554017249679413 0.102518406540157 1.34212588143118 0.391304347826087 22.4 22 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0554017249679413 0.102518406540157 1.34212588143118 0.391304347826087 22.4 22 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0130888430144917 0.0297530728588205 1.33848868392053 0.390243902439024 22.4 22 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0130888430144917 0.0297530728588205 1.33848868392053 0.390243902439024 22.4 22 4 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0202830471795026 0.0438644014231493 1.33384115376803 0.388888888888889 22.4 22 4 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.08960972190445 0.15645967395096 1.33384115376803 0.388888888888889 22.4 22 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.08960972190445 0.15645967395096 1.33384115376803 0.388888888888889 22.4 22 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 4.37967548741816e-07 3.08528624682973e-06 1.32193185775224 0.385416666666667 22.4 22 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 8.48951011359334e-09 8.16254925111035e-08 1.32023052974999 0.384920634920635 22.4 22 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 8.48951011359334e-09 8.16254925111035e-08 1.32023052974999 0.384920634920635 22.4 22 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 8.48951011359334e-09 8.16254925111035e-08 1.32023052974999 0.384920634920635 22.4 22 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0499872058325704 0.0959360247178715 1.31918355867168 0.384615384615385 22.4 22 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0499872058325704 0.0959360247178715 1.31918355867168 0.384615384615385 22.4 22 4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.149169535011285 0.242592283795496 1.31918355867168 0.384615384615385 22.4 22 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.149169535011285 0.242592283795496 1.31918355867168 0.384615384615385 22.4 22 4 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.149169535011285 0.242592283795496 1.31918355867168 0.384615384615385 22.4 22 4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.149169535011285 0.242592283795496 1.31918355867168 0.384615384615385 22.4 22 4 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.149169535011285 0.242592283795496 1.31918355867168 0.384615384615385 22.4 22 4 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.149169535011285 0.242592283795496 1.31918355867168 0.384615384615385 22.4 22 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.149169535011285 0.242592283795496 1.31918355867168 0.384615384615385 22.4 22 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0287215275007186 0.0587223184389691 1.31142365538537 0.382352941176471 22.4 22 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0287215275007186 0.0587223184389691 1.31142365538537 0.382352941176471 22.4 22 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00651459998020697 0.0167165968967825 1.30958949642679 0.381818181818182 22.4 22 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0168037149456722 0.0370723819654132 1.30661990573195 0.380952380952381 22.4 22 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0800350945502726 0.141830559831928 1.30661990573195 0.380952380952381 22.4 22 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.53901517388054e-06 1.00000848969498e-05 1.30484460694698 0.380434782608696 22.4 22 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00542425194471552 0.0144274962940751 1.29323240669781 0.377049180327869 22.4 22 4 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.13097572489335 0.217986498857588 1.28620396970488 0.375 22.4 22 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.13097572489335 0.217986498857588 1.28620396970488 0.375 22.4 22 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.13097572489335 0.217986498857588 1.28620396970488 0.375 22.4 22 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.13097572489335 0.217986498857588 1.28620396970488 0.375 22.4 22 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.13097572489335 0.217986498857588 1.28620396970488 0.375 22.4 22 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00749628312688137 0.0190485908742003 1.27893728061051 0.372881355932203 22.4 22 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.021279035675258 0.0454655672160543 1.27623339629632 0.372093023255814 22.4 22 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.000176479239539019 0.000717514165325781 1.272373819493 0.370967741935484 22.4 22 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0192337077638759 0.0417218996158467 1.26756333246278 0.369565217391304 22.4 22 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.79273989456865e-39 1.32468962332373e-36 1.26655247802228 0.3692704970949 22.4 22 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0173804714803326 0.0381673007970885 1.25995490909866 0.36734693877551 22.4 22 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0173804714803326 0.0381673007970885 1.25995490909866 0.36734693877551 22.4 22 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.03591956168919e-16 1.51134566744308e-14 1.2535321218482 0.36547433903577 22.4 22 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0510282074557947 0.0961763433239681 1.24722809183504 0.363636363636364 22.4 22 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.000399813346605051 0.00149326612130968 1.24722809183504 0.363636363636364 22.4 22 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00695433971694279 0.0177030866139706 1.24270914947332 0.36231884057971 22.4 22 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0456649705963703 0.088530317654816 1.23856678564174 0.361111111111111 22.4 22 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0901371586845032 0.15718771667653 1.23475581091669 0.36 22.4 22 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.191080933664326 0.29945833546733 1.2249561616237 0.357142857142857 22.4 22 4 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.191080933664326 0.29945833546733 1.2249561616237 0.357142857142857 22.4 22 4 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.191080933664326 0.29945833546733 1.2249561616237 0.357142857142857 22.4 22 4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.191080933664326 0.29945833546733 1.2249561616237 0.357142857142857 22.4 22 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.191080933664326 0.29945833546733 1.2249561616237 0.357142857142857 22.4 22 4 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.191080933664326 0.29945833546733 1.2249561616237 0.357142857142857 22.4 22 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.191080933664326 0.29945833546733 1.2249561616237 0.357142857142857 22.4 22 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0328557987561364 0.0660364429802007 1.21951191201648 0.355555555555556 22.4 22 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0294775284555022 0.0600953051463891 1.21474819361017 0.354166666666667 22.4 22 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.165623007359572 0.266608076326551 1.21054491266342 0.352941176470588 22.4 22 4 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.165623007359572 0.266608076326551 1.21054491266342 0.352941176470588 22.4 22 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.165623007359572 0.266608076326551 1.21054491266342 0.352941176470588 22.4 22 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.165623007359572 0.266608076326551 1.21054491266342 0.352941176470588 22.4 22 4 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.144464051787112 0.237381461539331 1.20045703839122 0.35 22.4 22 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00690520836320091 0.0176095188187005 1.19839084727523 0.349397590361446 22.4 22 4 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.126614642809238 0.215517508035342 1.19300078349438 0.347826086956522 22.4 22 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0288231794915718 0.0588456017453467 1.18486668724329 0.345454545454545 22.4 22 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00610566959454175 0.0157825332883991 1.18017281808047 0.344086021505376 22.4 22 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0387105108824765 0.0754589821722796 1.16486397256291 0.339622641509434 22.4 22 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.10495279038368 0.182353871448079 1.14329241751545 0.333333333333333 22.4 22 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.10495279038368 0.182353871448079 1.14329241751545 0.333333333333333 22.4 22 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.118927608454707 0.203896369675961 1.14329241751545 0.333333333333333 22.4 22 4 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.118927608454707 0.203896369675961 1.14329241751545 0.333333333333333 22.4 22 4 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.154186252883453 0.249609826909162 1.14329241751545 0.333333333333333 22.4 22 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.154186252883453 0.249609826909162 1.14329241751545 0.333333333333333 22.4 22 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.176678530405532 0.280595478534678 1.14329241751545 0.333333333333333 22.4 22 4 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.203629650087133 0.31427873326897 1.14329241751545 0.333333333333333 22.4 22 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.203629650087133 0.31427873326897 1.14329241751545 0.333333333333333 22.4 22 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.37685845477956e-09 2.54305983545211e-08 1.14129015408723 0.332749562171629 22.4 22 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0164900003764445 0.0364367554901872 1.1303004582255 0.329545454545455 22.4 22 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00928893792211815 0.022252792362246 1.12250528265153 0.327272727272727 22.4 22 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000869850430233312 0.00292623442605674 1.11427484346684 0.3248730964467 22.4 22 4 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.110393371152888 0.191572886768975 1.11239262244747 0.324324324324324 22.4 22 4 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.161329424669371 0.26087701284604 1.10246054546133 0.321428571428571 22.4 22 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.184327003094723 0.291441472670878 1.09756072081483 0.32 22.4 22 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.184327003094723 0.291441472670878 1.09756072081483 0.32 22.4 22 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.184327003094723 0.291441472670878 1.09756072081483 0.32 22.4 22 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.211600876208766 0.326227569712973 1.09132458035566 0.318181818181818 22.4 22 4 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.244377770835103 0.36223913322745 1.08311913238306 0.315789473684211 22.4 22 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00610948582645583 0.0157825332883991 1.07857775237307 0.314465408805031 22.4 22 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00610948582645583 0.0157825332883991 1.07857775237307 0.314465408805031 22.4 22 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.146831883460752 0.240716325074482 1.07796142222885 0.314285714285714 22.4 22 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.166633262592511 0.267931223354964 1.07183664142074 0.3125 22.4 22 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.284486773353384 0.414779383690435 1.07183664142074 0.3125 22.4 22 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.284486773353384 0.414779383690435 1.07183664142074 0.3125 22.4 22 4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.284486773353384 0.414779383690435 1.07183664142074 0.3125 22.4 22 4 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.284486773353384 0.414779383690435 1.07183664142074 0.3125 22.4 22 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0178401428399481 0.0388173138551164 1.06832242292428 0.311475409836066 22.4 22 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.118542752216921 0.20372745942594 1.06707292301442 0.311111111111111 22.4 22 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00793820746960128 0.0199311692562608 1.06517927097713 0.31055900621118 22.4 22 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.189690489408954 0.29945833546733 1.06444466458335 0.310344827586207 22.4 22 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00967182661423494 0.0230922974363361 1.06215553627242 0.309677419354839 22.4 22 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0090125330852973 0.022252792362246 1.05860409029209 0.308641975308642 22.4 22 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00761266330034513 0.0193098393518558 1.05688078130789 0.308139534883721 22.4 22 4 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.216742108436065 0.333792229766797 1.05534684693734 0.307692307692308 22.4 22 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.150787388594238 0.244664143636944 1.05534684693734 0.307692307692308 22.4 22 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.150787388594238 0.244664143636944 1.05534684693734 0.307692307692308 22.4 22 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0202650299453751 0.0438644014231493 1.03862480182742 0.302816901408451 22.4 22 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0743594599084864 0.135311395715826 1.03798916853377 0.302631578947368 22.4 22 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0160691783242571 0.03556211626037 1.03106739493725 0.300613496932515 22.4 22 4 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.287197936141385 0.418303647010431 1.02896317576391 0.3 22.4 22 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.114515534587176 0.197044263261852 1.0182448093497 0.296875 22.4 22 4 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.251089149264414 0.371800061814008 1.0162599266804 0.296296296296296 22.4 22 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.334013342517472 0.474826160242121 1.00878742721952 0.294117647058824 22.4 22 4 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.334013342517472 0.474826160242121 1.00878742721952 0.294117647058824 22.4 22 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.177156796495987 0.281041383961862 1.00038086532602 0.291666666666667 22.4 22 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.252039629605425 0.372819535268732 0.995770815255394 0.290322580645161 22.4 22 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0573156575310705 0.105922312554173 0.983567741539029 0.286764705882353 22.4 22 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0576416833067167 0.106386660629647 0.979964929298959 0.285714285714286 22.4 22 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.063214428087321 0.116370156750657 0.976388414958452 0.284671532846715 22.4 22 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.063214428087321 0.116370156750657 0.976388414958452 0.284671532846715 22.4 22 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0757557242050907 0.137676111805676 0.972248670013141 0.283464566929134 22.4 22 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.22333344894822 0.334961274536383 0.969313136589188 0.282608695652174 22.4 22 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00229209632955818 0.00685221234655734 0.963137248694836 0.280808080808081 22.4 22 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.222014704178579 0.33486580260308 0.952743681262877 0.277777777777778 22.4 22 4 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.384160916529141 0.541248499228681 0.952743681262877 0.277777777777778 22.4 22 4 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.384160916529141 0.541248499228681 0.952743681262877 0.277777777777778 22.4 22 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.145803420834092 0.239305960607743 0.952743681262877 0.277777777777778 22.4 22 4 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.324060677080899 0.465326280006175 0.946173035185202 0.275862068965517 22.4 22 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0640563878945696 0.117767751904357 0.945533729080347 0.275675675675676 22.4 22 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.361894582059646 0.51088887923698 0.914633934012362 0.266666666666667 22.4 22 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.35522796286528 0.502974518564472 0.907908684497565 0.264705882352941 22.4 22 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.35522796286528 0.502974518564472 0.907908684497565 0.264705882352941 22.4 22 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.291176551917725 0.423664860305647 0.899639935094127 0.262295081967213 22.4 22 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.400105000304592 0.548251260166021 0.88512961356035 0.258064516129032 22.4 22 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00363459650739291 0.0100233155620545 0.85830586856404 0.250243902439024 22.4 22 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.397728839594629 0.548251260166021 0.857469313136589 0.25 22.4 22 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.451212704102842 0.606876822247963 0.857469313136589 0.25 22.4 22 4 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.483045312703172 0.643006061718068 0.857469313136589 0.25 22.4 22 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.358873884342801 0.507127643912418 0.847381438864394 0.247058823529412 22.4 22 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.358873884342801 0.507127643912418 0.847381438864394 0.247058823529412 22.4 22 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.401258670639751 0.548502486378834 0.843412439150744 0.245901639344262 22.4 22 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.418730165269858 0.564254758692242 0.841290646850993 0.245283018867925 22.4 22 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.418730165269858 0.564254758692242 0.841290646850993 0.245283018867925 22.4 22 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.254437515095672 0.375975684300251 0.840251053836658 0.244979919678715 22.4 22 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.462455023197022 0.620824054725814 0.8342944668356 0.243243243243243 22.4 22 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.458980612866394 0.616741654493748 0.823170540611126 0.24 22.4 22 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.325536746622696 0.466974587141226 0.820480440805207 0.23921568627451 22.4 22 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.502391700047332 0.66379144769485 0.80273722931936 0.234042553191489 22.4 22 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.43879781078092 0.59073726087157 0.79357944274602 0.231372549019608 22.4 22 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.551609107375712 0.711640761374105 0.791510135203006 0.230769230769231 22.4 22 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.551609107375712 0.711640761374105 0.791510135203006 0.230769230769231 22.4 22 4 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.575756276100253 0.737444807282322 0.779517557396899 0.227272727272727 22.4 22 4 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.575756276100253 0.737444807282322 0.779517557396899 0.227272727272727 22.4 22 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.532150520194487 0.69257772952367 0.773813770391556 0.225609756097561 22.4 22 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.592023770096561 0.754883355598034 0.762194945010302 0.222222222222222 22.4 22 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.592023770096561 0.754883355598034 0.762194945010302 0.222222222222222 22.4 22 4 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.592023770096561 0.754883355598034 0.762194945010302 0.222222222222222 22.4 22 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.612433060650748 0.780207918805743 0.745625489683991 0.217391304347826 22.4 22 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.63201878856257 0.796714731727384 0.738074851813773 0.215189873417722 22.4 22 4 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.630426788094848 0.796714731727384 0.734973696974219 0.214285714285714 22.4 22 4 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.630426788094848 0.796714731727384 0.734973696974219 0.214285714285714 22.4 22 4 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.641067018853025 0.796714731727384 0.727549720237106 0.212121212121212 22.4 22 4 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.658846272380067 0.815960178935453 0.714557760947158 0.208333333333333 22.4 22 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.695062919750946 0.85121855573821 0.699974949499257 0.204081632653061 22.4 22 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.730133442189824 0.876037005258111 0.694658684060022 0.20253164556962 22.4 22 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.745078206689291 0.887564018654924 0.693273061684902 0.202127659574468 22.4 22 4 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.696195448454316 0.85121855573821 0.685975450509271 0.2 22.4 22 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.762018101575206 0.902874070392605 0.685975450509271 0.2 22.4 22 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.731951217188003 0.877478165171464 0.663847210170262 0.193548387096774 22.4 22 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.760995174863627 0.902413444859117 0.643101984852442 0.1875 22.4 22 4 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.786322041558519 0.921693793358956 0.631819493890118 0.184210526315789 22.4 22 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.923478328482089 1 0.593632601402254 0.173076923076923 22.4 22 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.924189471414143 1 0.588968821144324 0.171717171717172 22.4 22 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.839832411975617 0.979575018230576 0.571646208757726 0.166666666666667 22.4 22 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.944523200433199 1 0.565752948873626 0.164948453608247 22.4 22 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.993075700830716 1 0.534765808192712 0.155913978494624 22.4 22 4 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.922324169994461 1 0.489982464649479 0.142857142857143 22.4 22 4 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.961978989974221 1 0.481386281059138 0.140350877192982 22.4 22 4 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.983968911507062 1 0.435539968577315 0.126984126984127 22.4 22 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.974308364662071 1 0.428734656568295 0.125 22.4 22 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.406055997152843 0.118387909319899 22.4 22 4 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.978581523718021 1 0.3988229363426 0.116279069767442 22.4 22 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999992209821 1 0.397795042176768 0.115979381443299 22.4 22 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.995356106124031 1 0.386465042540435 0.112676056338028 22.4 22 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999308488387856 1 0.381097472505151 0.111111111111111 22.4 22 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999996288366868 1 0.379341262954436 0.110599078341014 22.4 22 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999996000805 1 0.330738163638399 0.0964285714285714 22.4 22 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.31321663879492 0.0913200723327306 22.4 22 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999937988478 1 0.272831145088915 0.0795454545454545 22.4 22 4 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999988795850599 1 0.22865848350309 0.0666666666666667 22.4 22 4 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.000107047170177641 0.000989143656901187 5.22230374174615 1 22.2 22 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.000556330319636319 0.0040390716573596 4.35191978478846 0.833333333333333 22.2 22 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.000358152068443186 0.00281574802980471 3.91672780630961 0.75 22.2 22 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.000927572994232801 0.00602710671595103 3.48153582783077 0.666666666666667 22.2 22 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 1.18579323875609e-06 2.55664208901503e-05 3.394497432135 0.65 22.2 22 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 1.18579323875609e-06 2.55664208901503e-05 3.394497432135 0.65 22.2 22 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.000498431310411002 0.00369051945468627 3.323284199293 0.636363636363636 22.2 22 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.000498431310411002 0.00369051945468627 3.323284199293 0.636363636363636 22.2 22 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.000498431310411002 0.00369051945468627 3.323284199293 0.636363636363636 22.2 22 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00390367806790722 0.0182728088507631 3.26393983859134 0.625 22.2 22 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00390367806790722 0.0182728088507631 3.26393983859134 0.625 22.2 22 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00390367806790722 0.0182728088507631 3.26393983859134 0.625 22.2 22 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00390367806790722 0.0182728088507631 3.26393983859134 0.625 22.2 22 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.000265055007075936 0.00220569166707051 3.21372537953609 0.615384615384615 22.2 22 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.000265055007075936 0.00220569166707051 3.21372537953609 0.615384615384615 22.2 22 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000140231160894863 0.00123178359230488 3.13338224504769 0.6 22.2 22 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000140231160894863 0.00123178359230488 3.13338224504769 0.6 22.2 22 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00200303812048034 0.0110051090557665 3.13338224504769 0.6 22.2 22 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00200303812048034 0.0110051090557665 3.13338224504769 0.6 22.2 22 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00200303812048034 0.0110051090557665 3.13338224504769 0.6 22.2 22 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 7.40044931717502e-05 0.000698011440260582 3.07194337749773 0.588235294117647 22.2 22 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 7.40044931717502e-05 0.000698011440260582 3.07194337749773 0.588235294117647 22.2 22 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0010299972324115 0.0064853365562901 3.04634384935192 0.583333333333333 22.2 22 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000531175319169246 0.00387621784193763 2.98417356671209 0.571428571428571 22.2 22 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000274727691376388 0.0022597543631711 2.93754585473221 0.5625 22.2 22 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 7.40686770761405e-05 0.000698011440260582 2.87226705796038 0.55 22.2 22 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00380856629256354 0.0180652994477264 2.84852931367972 0.545454545454545 22.2 22 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00380856629256354 0.0180652994477264 2.84852931367972 0.545454545454545 22.2 22 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00380856629256354 0.0180652994477264 2.84852931367972 0.545454545454545 22.2 22 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00380856629256354 0.0180652994477264 2.84852931367972 0.545454545454545 22.2 22 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00380856629256354 0.0180652994477264 2.84852931367972 0.545454545454545 22.2 22 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00380856629256354 0.0180652994477264 2.84852931367972 0.545454545454545 22.2 22 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00380856629256354 0.0180652994477264 2.84852931367972 0.545454545454545 22.2 22 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00380856629256354 0.0180652994477264 2.84852931367972 0.545454545454545 22.2 22 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.05336848553189e-05 0.000149894335491187 2.81200970709408 0.538461538461538 22.2 22 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00192242982863632 0.0107015222666598 2.81200970709408 0.538461538461538 22.2 22 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 8.08534057901971e-13 4.26127394220187e-11 2.80036577455953 0.536231884057971 22.2 22 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.89312364803469e-06 4.73208615075099e-05 2.78522866226461 0.533333333333333 22.2 22 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.000977968642911398 0.00624058017427318 2.78522866226461 0.533333333333333 22.2 22 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000977968642911398 0.00624058017427318 2.78522866226461 0.533333333333333 22.2 22 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000977968642911398 0.00624058017427318 2.78522866226461 0.533333333333333 22.2 22 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000977968642911398 0.00624058017427318 2.78522866226461 0.533333333333333 22.2 22 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000500541289356606 0.00369051945468627 2.76474903974796 0.529411764705882 22.2 22 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.21333411361442e-11 1.47502401408817e-09 2.73549243615274 0.523809523809524 22.2 22 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000132934464541741 0.00119725153824619 2.73549243615274 0.523809523809524 22.2 22 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.71577256144576e-08 5.95498623155444e-07 2.72468021308495 0.521739130434783 22.2 22 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 6.54338420371087e-07 1.57817554608145e-05 2.61115187087307 0.5 22.2 22 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 8.6516173951341e-06 0.000125625015849753 2.61115187087307 0.5 22.2 22 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 6.10333325755345e-05 0.000603400461135636 2.61115187087307 0.5 22.2 22 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000117601664064245 0.00107273825617577 2.61115187087307 0.5 22.2 22 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000440806210746433 0.00337240450479663 2.61115187087307 0.5 22.2 22 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000440806210746433 0.00337240450479663 2.61115187087307 0.5 22.2 22 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000858607274746222 0.005688319019144 2.61115187087307 0.5 22.2 22 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00168120959444641 0.00960787651765962 2.61115187087307 0.5 22.2 22 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00331368433810338 0.0168406171897183 2.61115187087307 0.5 22.2 22 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00331368433810338 0.0168406171897183 2.61115187087307 0.5 22.2 22 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00331368433810338 0.0168406171897183 2.61115187087307 0.5 22.2 22 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00331368433810338 0.0168406171897183 2.61115187087307 0.5 22.2 22 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00331368433810338 0.0168406171897183 2.61115187087307 0.5 22.2 22 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00658713535271559 0.0279805779310874 2.61115187087307 0.5 22.2 22 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00658713535271559 0.0279805779310874 2.61115187087307 0.5 22.2 22 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00658713535271559 0.0279805779310874 2.61115187087307 0.5 22.2 22 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00658713535271559 0.0279805779310874 2.61115187087307 0.5 22.2 22 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00658713535271559 0.0279805779310874 2.61115187087307 0.5 22.2 22 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00658713535271559 0.0279805779310874 2.61115187087307 0.5 22.2 22 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0132445806995201 0.0480791794270846 2.61115187087307 0.5 22.2 22 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0132445806995201 0.0480791794270846 2.61115187087307 0.5 22.2 22 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0132445806995201 0.0480791794270846 2.61115187087307 0.5 22.2 22 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0132445806995201 0.0480791794270846 2.61115187087307 0.5 22.2 22 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0132445806995201 0.0480791794270846 2.61115187087307 0.5 22.2 22 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0132445806995201 0.0480791794270846 2.61115187087307 0.5 22.2 22 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.08432656246306e-06 2.41093234122647e-05 2.54746523987617 0.48780487804878 22.2 22 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.08432656246306e-06 2.41093234122647e-05 2.54746523987617 0.48780487804878 22.2 22 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 4.59279831373329e-12 2.25363862084223e-10 2.51899356954814 0.482352941176471 22.2 22 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.58008943675713e-07 7.06051397789499e-06 2.50235387625336 0.479166666666667 22.2 22 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00535743557139636 0.0233853706076596 2.43707507948154 0.466666666666667 22.2 22 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00535743557139636 0.0233853706076596 2.43707507948154 0.466666666666667 22.2 22 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.010585454373355 0.0404922085303336 2.41029403465207 0.461538461538462 22.2 22 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.010585454373355 0.0404922085303336 2.41029403465207 0.461538461538462 22.2 22 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.010585454373355 0.0404922085303336 2.41029403465207 0.461538461538462 22.2 22 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.89708852968203e-05 0.000254675186579012 2.3994368543158 0.459459459459459 22.2 22 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000588154667554828 0.00416390095487821 2.39355588163365 0.458333333333333 22.2 22 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000588154667554828 0.00416390095487821 2.39355588163365 0.458333333333333 22.2 22 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000588154667554828 0.00416390095487821 2.39355588163365 0.458333333333333 22.2 22 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000588154667554828 0.00416390095487821 2.39355588163365 0.458333333333333 22.2 22 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 3.59982539191297e-05 0.000419881273171488 2.38733885336967 0.457142857142857 22.2 22 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 3.59982539191297e-05 0.000419881273171488 2.38733885336967 0.457142857142857 22.2 22 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00113186511159077 0.00694243126635201 2.37377442806643 0.454545454545455 22.2 22 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00113186511159077 0.00694243126635201 2.37377442806643 0.454545454545455 22.2 22 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00113186511159077 0.00694243126635201 2.37377442806643 0.454545454545455 22.2 22 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0211079260386506 0.067582160498895 2.37377442806643 0.454545454545455 22.2 22 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0211079260386506 0.067582160498895 2.37377442806643 0.454545454545455 22.2 22 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0211079260386506 0.067582160498895 2.37377442806643 0.454545454545455 22.2 22 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0211079260386506 0.067582160498895 2.37377442806643 0.454545454545455 22.2 22 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 5.32129738967556e-07 1.32845722552778e-05 2.36481678871524 0.452830188679245 22.2 22 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.99868526822736e-07 2.29485953817541e-05 2.35515658941493 0.450980392156863 22.2 22 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.99868526822736e-07 2.29485953817541e-05 2.35515658941493 0.450980392156863 22.2 22 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00218417695938503 0.0117730447469882 2.35003668378577 0.45 22.2 22 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00218417695938503 0.0117730447469882 2.35003668378577 0.45 22.2 22 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00218417695938503 0.0117730447469882 2.35003668378577 0.45 22.2 22 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 2.91964404042494e-05 0.000355212299632444 2.33629377920222 0.447368421052632 22.2 22 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.33568609998642e-07 1.12176024005103e-05 2.33138559899382 0.446428571428571 22.2 22 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.17387424357816e-13 1.2849408066244e-11 2.33061489301068 0.446280991735537 22.2 22 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.17387424357816e-13 1.2849408066244e-11 2.33061489301068 0.446280991735537 22.2 22 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00422836073835025 0.0194723538209463 2.32102388522051 0.444444444444444 22.2 22 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000898534244440043 0.00589223147390867 2.29781364636831 0.44 22.2 22 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 2.34301805916951e-05 0.000297688812339127 2.29271871588855 0.439024390243902 22.2 22 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 8.04685701743991e-15 1.27229750397967e-12 2.29180236148572 0.438848920863309 22.2 22 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00821672244235746 0.032936326860492 2.28475788701394 0.4375 22.2 22 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00821672244235746 0.032936326860492 2.28475788701394 0.4375 22.2 22 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.91284599907999e-09 7.77708530483095e-08 2.27323809934832 0.435294117647059 22.2 22 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.91284599907999e-09 7.77708530483095e-08 2.27323809934832 0.435294117647059 22.2 22 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.91284599907999e-09 7.77708530483095e-08 2.27323809934832 0.435294117647059 22.2 22 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 9.96841318040167e-06 0.000143283353087996 2.27056684423746 0.434782608695652 22.2 22 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00171600401207984 0.00976749483675847 2.27056684423746 0.434782608695652 22.2 22 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.58350091035571e-13 2.62594413959726e-11 2.24960776567526 0.430769230769231 22.2 22 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0160392818997937 0.0564947973846692 2.23813017503406 0.428571428571429 22.2 22 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0160392818997937 0.0564947973846692 2.23813017503406 0.428571428571429 22.2 22 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00328179246663351 0.0168406171897183 2.23813017503406 0.428571428571429 22.2 22 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.78831526239688e-08 6.0589824247399e-07 2.21947909024211 0.425 22.2 22 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 6.51382408588627e-05 0.000639253218911459 2.21947909024211 0.425 22.2 22 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 7.68179456290417e-08 2.23085584959442e-06 2.21769063005658 0.424657534246575 22.2 22 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.0013328037901985 0.00803635505700195 2.20943619843106 0.423076923076923 22.2 22 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0013328037901985 0.00803635505700195 2.20943619843106 0.423076923076923 22.2 22 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.81839782038849e-07 1.224389303288e-05 2.18245529505809 0.417910447761194 22.2 22 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.08402388216318e-06 3.57297106544362e-05 2.17595989239423 0.416666666666667 22.2 22 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.08402388216318e-06 3.57297106544362e-05 2.17595989239423 0.416666666666667 22.2 22 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.08402388216318e-06 3.57297106544362e-05 2.17595989239423 0.416666666666667 22.2 22 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.08402388216318e-06 3.57297106544362e-05 2.17595989239423 0.416666666666667 22.2 22 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.08402388216318e-06 3.57297106544362e-05 2.17595989239423 0.416666666666667 22.2 22 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.08402388216318e-06 3.57297106544362e-05 2.17595989239423 0.416666666666667 22.2 22 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.08402388216318e-06 3.57297106544362e-05 2.17595989239423 0.416666666666667 22.2 22 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.000226958827873889 0.001922395309908 2.17595989239423 0.416666666666667 22.2 22 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00252161068674057 0.0134391460945012 2.17595989239423 0.416666666666667 22.2 22 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0314799193857471 0.0907307897333853 2.17595989239423 0.416666666666667 22.2 22 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0314799193857471 0.0907307897333853 2.17595989239423 0.416666666666667 22.2 22 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0314799193857471 0.0907307897333853 2.17595989239423 0.416666666666667 22.2 22 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00102725266218668 0.0064853365562901 2.16095327244668 0.413793103448276 22.2 22 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00102725266218668 0.0064853365562901 2.16095327244668 0.413793103448276 22.2 22 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 3.97040778286092e-05 0.000434606944231623 2.15703850202558 0.41304347826087 22.2 22 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0120569433793949 0.0447964240962896 2.15036036424841 0.411764705882353 22.2 22 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0120569433793949 0.0447964240962896 2.15036036424841 0.411764705882353 22.2 22 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0120569433793949 0.0447964240962896 2.15036036424841 0.411764705882353 22.2 22 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0120569433793949 0.0447964240962896 2.15036036424841 0.411764705882353 22.2 22 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0120569433793949 0.0447964240962896 2.15036036424841 0.411764705882353 22.2 22 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0120569433793949 0.0447964240962896 2.15036036424841 0.411764705882353 22.2 22 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.95754595032076e-07 7.94073186284233e-06 2.1461522226354 0.410958904109589 22.2 22 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00477020371243232 0.0218263661826083 2.13639698525979 0.409090909090909 22.2 22 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00477020371243232 0.0218263661826083 2.13639698525979 0.409090909090909 22.2 22 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 9.89780280980291e-09 3.61142907649988e-07 2.13384453963821 0.408602150537634 22.2 22 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0019252211526809 0.0107015222666598 2.1276052281188 0.407407407407407 22.2 22 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0019252211526809 0.0107015222666598 2.1276052281188 0.407407407407407 22.2 22 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0019252211526809 0.0107015222666598 2.1276052281188 0.407407407407407 22.2 22 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 5.66459497529166e-05 0.000584110047089857 2.11114406581227 0.404255319148936 22.2 22 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.000103996490485821 0.000967235333080545 2.08892149669846 0.4 22.2 22 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00146376776618465 0.00857177584889202 2.08892149669846 0.4 22.2 22 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00360366164827425 0.0176827949154975 2.08892149669846 0.4 22.2 22 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.00360366164827425 0.0176827949154975 2.08892149669846 0.4 22.2 22 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00360366164827425 0.0176827949154975 2.08892149669846 0.4 22.2 22 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00360366164827425 0.0176827949154975 2.08892149669846 0.4 22.2 22 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00360366164827425 0.0176827949154975 2.08892149669846 0.4 22.2 22 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00901987794354232 0.035653573093502 2.08892149669846 0.4 22.2 22 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00901987794354232 0.035653573093502 2.08892149669846 0.4 22.2 22 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0231605127853918 0.0722705795299288 2.08892149669846 0.4 22.2 22 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0231605127853918 0.0722705795299288 2.08892149669846 0.4 22.2 22 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.63205269573682e-16 9.36352746508373e-14 2.06405338364253 0.395238095238095 22.2 22 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.95310932627279e-06 3.57297106544362e-05 2.0595000671675 0.394366197183099 22.2 22 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 6.09573132175758e-05 0.000603400461135636 2.04796225166516 0.392156862745098 22.2 22 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00673361780551606 0.0282653042396736 2.04351015981371 0.391304347826087 22.2 22 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00673361780551606 0.0282653042396736 2.04351015981371 0.391304347826087 22.2 22 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00673361780551606 0.0282653042396736 2.04351015981371 0.391304347826087 22.2 22 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00673361780551606 0.0282653042396736 2.04351015981371 0.391304347826087 22.2 22 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 8.31846878017521e-06 0.000122032794579271 2.03996239911959 0.390625 22.2 22 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000348237403195159 0.00275301013748173 2.03797219190094 0.390243902439024 22.2 22 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000348237403195159 0.00275301013748173 2.03797219190094 0.390243902439024 22.2 22 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.96477814886476e-05 0.0002588777135032 2.03581332305358 0.389830508474576 22.2 22 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.96477814886476e-05 0.0002588777135032 2.03581332305358 0.389830508474576 22.2 22 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0170387686964232 0.0564982393749927 2.03089589956795 0.388888888888889 22.2 22 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.07397201460449e-06 3.57297106544362e-05 2.01929078014184 0.386666666666667 22.2 22 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.07397201460449e-06 3.57297106544362e-05 2.01929078014184 0.386666666666667 22.2 22 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.07397201460449e-06 3.57297106544362e-05 2.01929078014184 0.386666666666667 22.2 22 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.07397201460449e-06 3.57297106544362e-05 2.01929078014184 0.386666666666667 22.2 22 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.07397201460449e-06 3.57297106544362e-05 2.01929078014184 0.386666666666667 22.2 22 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.13309081186236e-08 1.01327005120003e-06 2.00857836221006 0.384615384615385 22.2 22 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00502294780957162 0.0224253273764033 2.00857836221006 0.384615384615385 22.2 22 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00502294780957162 0.0224253273764033 2.00857836221006 0.384615384615385 22.2 22 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0445389600184923 0.120263643465492 2.00857836221006 0.384615384615385 22.2 22 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0445389600184923 0.120263643465492 2.00857836221006 0.384615384615385 22.2 22 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0445389600184923 0.120263643465492 2.00857836221006 0.384615384615385 22.2 22 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000200370940778165 0.0017073523875888 2.00003122024321 0.382978723404255 22.2 22 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00153494639647486 0.00895175705813 1.99676319537353 0.382352941176471 22.2 22 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0125510074677939 0.0463898276017421 1.98944904447472 0.380952380952381 22.2 22 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0125510074677939 0.0463898276017421 1.98944904447472 0.380952380952381 22.2 22 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.1667694589083e-06 3.62742698826648e-05 1.98315331965044 0.379746835443038 22.2 22 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.1667694589083e-06 3.62742698826648e-05 1.98315331965044 0.379746835443038 22.2 22 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.00374654680848542 0.0180652994477264 1.98087383307613 0.379310344827586 22.2 22 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00115302515637721 0.00701177263899473 1.97600682120125 0.378378378378378 22.2 22 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00115302515637721 0.00701177263899473 1.97600682120125 0.378378378378378 22.2 22 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.18929996924203e-05 0.000165919005512883 1.96782459833913 0.376811594202899 22.2 22 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.18929996924203e-05 0.000165919005512883 1.96782459833913 0.376811594202899 22.2 22 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 4.43462586627451e-08 1.40232724615747e-06 1.96435278359259 0.376146788990826 22.2 22 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0321267869912125 0.0907307897333853 1.95836390315481 0.375 22.2 22 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00208653194687543 0.0114197498477067 1.93971281836285 0.371428571428571 22.2 22 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.94954446321408e-06 6.24466863461515e-05 1.93418657101709 0.37037037037037 22.2 22 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.94954446321408e-06 6.24466863461515e-05 1.93418657101709 0.37037037037037 22.2 22 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00684513996068377 0.0283983503325161 1.93418657101709 0.37037037037037 22.2 22 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00684513996068377 0.0283983503325161 1.93418657101709 0.37037037037037 22.2 22 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00684513996068377 0.0283983503325161 1.93418657101709 0.37037037037037 22.2 22 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00684513996068377 0.0283983503325161 1.93418657101709 0.37037037037037 22.2 22 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.70021695410166e-09 3.25800229623333e-07 1.93266358946511 0.37007874015748 22.2 22 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0233114518652406 0.0722705795299288 1.92400664169595 0.368421052631579 22.2 22 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0233114518652406 0.0722705795299288 1.92400664169595 0.368421052631579 22.2 22 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0233114518652406 0.0722705795299288 1.92400664169595 0.368421052631579 22.2 22 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0233114518652406 0.0722705795299288 1.92400664169595 0.368421052631579 22.2 22 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000366897767817797 0.00286865672310289 1.91839729288634 0.36734693877551 22.2 22 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 6.96813313383547e-06 0.000105485674994126 1.91704820899542 0.367088607594937 22.2 22 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.00506815572771218 0.0225374550016701 1.91484470530692 0.366666666666667 22.2 22 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0169971810422862 0.0564982393749927 1.89901954245314 0.363636363636364 22.2 22 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0169971810422862 0.0564982393749927 1.89901954245314 0.363636363636364 22.2 22 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.77778517886491e-05 0.000419983461681622 1.89213903686455 0.36231884057971 22.2 22 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.77778517886491e-05 0.000419983461681622 1.89213903686455 0.36231884057971 22.2 22 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.000651664768163386 0.00452350714681219 1.88891837467414 0.361702127659574 22.2 22 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.84873203939845e-05 0.000354953184437628 1.88583190674166 0.361111111111111 22.2 22 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.54978212010227e-08 5.51334989226384e-07 1.88474120002869 0.360902255639098 22.2 22 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.17926158965538e-08 1.83189359209992e-06 1.88345380849861 0.360655737704918 22.2 22 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.14837842192726e-05 0.000277922044945681 1.88002934702861 0.36 22.2 22 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 6.62501792385523e-05 0.000641319762288843 1.87067596719265 0.358208955223881 22.2 22 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 6.62501792385523e-05 0.000641319762288843 1.87067596719265 0.358208955223881 22.2 22 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00913961193430521 0.0358513491563862 1.86510847919505 0.357142857142857 22.2 22 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00913961193430521 0.0358513491563862 1.86510847919505 0.357142857142857 22.2 22 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0603721145288802 0.15124915312429 1.86510847919505 0.357142857142857 22.2 22 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0603721145288802 0.15124915312429 1.86510847919505 0.357142857142857 22.2 22 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0603721145288802 0.15124915312429 1.86510847919505 0.357142857142857 22.2 22 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0603721145288802 0.15124915312429 1.86510847919505 0.357142857142857 22.2 22 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0603721145288802 0.15124915312429 1.86510847919505 0.357142857142857 22.2 22 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0603721145288802 0.15124915312429 1.86510847919505 0.357142857142857 22.2 22 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0603721145288802 0.15124915312429 1.86510847919505 0.357142857142857 22.2 22 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00154539872923275 0.00897592812938042 1.86510847919505 0.357142857142857 22.2 22 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000859443843370317 0.005688319019144 1.84956590853509 0.354166666666667 22.2 22 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000115712206576691 0.00106231270941052 1.84789209323325 0.353846153846154 22.2 22 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.20727542985966e-05 0.000166787230586017 1.84316602649864 0.352941176470588 22.2 22 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.92696636536896e-15 1.23213414224e-12 1.84316602649864 0.352941176470588 22.2 22 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000641838754501275 0.00447713993948684 1.84316602649864 0.352941176470588 22.2 22 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00497120270218728 0.0224253273764033 1.84316602649864 0.352941176470588 22.2 22 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00497120270218728 0.0224253273764033 1.84316602649864 0.352941176470588 22.2 22 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00497120270218728 0.0224253273764033 1.84316602649864 0.352941176470588 22.2 22 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00497120270218728 0.0224253273764033 1.84316602649864 0.352941176470588 22.2 22 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0430739744158403 0.117197448553998 1.84316602649864 0.352941176470588 22.2 22 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0430739744158403 0.117197448553998 1.84316602649864 0.352941176470588 22.2 22 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00367852475354669 0.0179881124546287 1.83486347682973 0.351351351351351 22.2 22 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 5.54117324549355e-07 1.35949819454092e-05 1.83238727780567 0.350877192982456 22.2 22 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 3.75386361679002e-09 1.48381886852561e-07 1.82780630961115 0.35 22.2 22 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00272700838296427 0.0143723441813265 1.82780630961115 0.35 22.2 22 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.78613675017624e-12 1.92416878410742e-10 1.82663538948968 0.349775784753363 22.2 22 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0224710814352303 0.0705879666276661 1.81645347538996 0.347826086956522 22.2 22 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0224710814352303 0.0705879666276661 1.81645347538996 0.347826086956522 22.2 22 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000835697010257563 0.00558308378214325 1.80772052598905 0.346153846153846 22.2 22 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0163712244104168 0.0564982393749927 1.80772052598905 0.346153846153846 22.2 22 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0163712244104168 0.0564982393749927 1.80772052598905 0.346153846153846 22.2 22 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0163712244104168 0.0564982393749927 1.80772052598905 0.346153846153846 22.2 22 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.000465759396124756 0.00350674931579645 1.80079439370557 0.344827586206897 22.2 22 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.000465759396124756 0.00350674931579645 1.80079439370557 0.344827586206897 22.2 22 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.011978067263684 0.0447964240962896 1.80079439370557 0.344827586206897 22.2 22 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000348171847103719 0.00275301013748173 1.79784227174867 0.344262295081967 22.2 22 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000348171847103719 0.00275301013748173 1.79784227174867 0.344262295081967 22.2 22 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000348171847103719 0.00275301013748173 1.79784227174867 0.344262295081967 22.2 22 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.000195004962951075 0.00167163892939386 1.79273113522629 0.343283582089552 22.2 22 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000447548383466845 0.00340567566670225 1.76884481575273 0.338709677419355 22.2 22 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.54603736151659e-06 7.0315338754762e-05 1.75659307676916 0.336363636363636 22.2 22 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.85711311424801e-06 3.57297106544362e-05 1.74076791391538 0.333333333333333 22.2 22 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.2430777182941e-05 0.000453977413017481 1.74076791391538 0.333333333333333 22.2 22 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000570718622708958 0.00412250050819719 1.74076791391538 0.333333333333333 22.2 22 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00831877894185953 0.0332517484108599 1.74076791391538 0.333333333333333 22.2 22 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.01543302303167 0.0549446133944433 1.74076791391538 0.333333333333333 22.2 22 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0290762111144549 0.0869232109577088 1.74076791391538 0.333333333333333 22.2 22 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0560915772755488 0.144260555999442 1.74076791391538 0.333333333333333 22.2 22 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0560915772755488 0.144260555999442 1.74076791391538 0.333333333333333 22.2 22 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0560915772755488 0.144260555999442 1.74076791391538 0.333333333333333 22.2 22 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0560915772755488 0.144260555999442 1.74076791391538 0.333333333333333 22.2 22 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0789779154006245 0.186997626647402 1.74076791391538 0.333333333333333 22.2 22 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0789779154006245 0.186997626647402 1.74076791391538 0.333333333333333 22.2 22 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0211342666352834 0.067582160498895 1.74076791391538 0.333333333333333 22.2 22 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0402348683853353 0.111389528623214 1.74076791391538 0.333333333333333 22.2 22 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0402348683853353 0.111389528623214 1.74076791391538 0.333333333333333 22.2 22 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.000169316359256479 0.001460225328618 1.71873287703038 0.329113924050633 22.2 22 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.75872614430679e-07 4.90719079087952e-06 1.71830639244551 0.329032258064516 22.2 22 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.21896500217469e-05 0.000166787230586017 1.70911758820783 0.327272727272727 22.2 22 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.80857829268219e-05 0.0004201245667044 1.70524203812119 0.326530612244898 22.2 22 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0143455816348501 0.0519434164539229 1.68956885762375 0.323529411764706 22.2 22 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0195762089942397 0.0636003319607375 1.68461411024069 0.32258064516129 22.2 22 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.026815945177852 0.0810750443193927 1.67859763127555 0.321428571428571 22.2 22 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.026815945177852 0.0810750443193927 1.67859763127555 0.321428571428571 22.2 22 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.9400320528395e-05 0.000599479830580894 1.67113719735877 0.32 22.2 22 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 5.9400320528395e-05 0.000599479830580894 1.67113719735877 0.32 22.2 22 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.9400320528395e-05 0.000599479830580894 1.67113719735877 0.32 22.2 22 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0369036164305198 0.102968325844372 1.67113719735877 0.32 22.2 22 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0369036164305198 0.102968325844372 1.67113719735877 0.32 22.2 22 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0510791224787584 0.13560744643148 1.6616420996465 0.318181818181818 22.2 22 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.17328377332202e-05 0.00045332693201811 1.65942361887261 0.317757009345794 22.2 22 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00974102019894072 0.0377696777740944 1.65585240591951 0.317073170731707 22.2 22 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0712208659264603 0.171178487919151 1.6491485500251 0.315789473684211 22.2 22 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 5.15851685276714e-05 0.000535807991349463 1.64405858536453 0.314814814814815 22.2 22 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000230473803778993 0.00194061670282549 1.64297196369542 0.314606741573034 22.2 22 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.30866939260651e-08 7.64008498995132e-07 1.64129546169165 0.314285714285714 22.2 22 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 6.84901631069091e-05 0.000658523662845484 1.64129546169165 0.314285714285714 22.2 22 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.0010487791068041 0.00654566960079929 1.64129546169165 0.314285714285714 22.2 22 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0010487791068041 0.00654566960079929 1.64129546169165 0.314285714285714 22.2 22 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000408612026670532 0.00317734925656922 1.63590237693253 0.313253012048193 22.2 22 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.000120832877086409 0.00109519225537554 1.63526682822354 0.313131313131313 22.2 22 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00187564436080481 0.0105914362120049 1.63196991929567 0.3125 22.2 22 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.100273882859448 0.224708244581094 1.63196991929567 0.3125 22.2 22 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.100273882859448 0.224708244581094 1.63196991929567 0.3125 22.2 22 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.100273882859448 0.224708244581094 1.63196991929567 0.3125 22.2 22 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.22454867122968e-07 3.48506551831967e-06 1.63196991929567 0.3125 22.2 22 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.2390390450545e-15 1.00535876018543e-12 1.63043755317427 0.312206572769953 22.2 22 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 7.70128607224041e-18 3.65297669359937e-15 1.61831845989472 0.309885931558935 22.2 22 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 5.60842652529213e-08 1.73495455336754e-06 1.61642734863571 0.30952380952381 22.2 22 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.09085684414267e-05 0.000372736380441951 1.61339465192157 0.308943089430894 22.2 22 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00010321581807571 0.000966290191590366 1.61061704184694 0.308411214953271 22.2 22 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00606551856645902 0.0262347505169337 1.60686268976805 0.307692307692308 22.2 22 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00606551856645902 0.0262347505169337 1.60686268976805 0.307692307692308 22.2 22 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.016350575546256 0.0564982393749927 1.60686268976805 0.307692307692308 22.2 22 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.0460291239950102 0.124051976221401 1.60686268976805 0.307692307692308 22.2 22 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.77227000020573e-05 0.000419983461681622 1.60038340472866 0.306451612903226 22.2 22 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.77227000020573e-05 0.000419983461681622 1.60038340472866 0.306451612903226 22.2 22 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.77227000020573e-05 0.000419983461681622 1.60038340472866 0.306451612903226 22.2 22 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.17830596230141e-06 5.13946520949421e-05 1.59933052090976 0.30625 22.2 22 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.00815733419252869 0.0328835313200236 1.59866441073862 0.306122448979592 22.2 22 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.76499440038005e-07 1.6044311719568e-05 1.59808201933215 0.306010928961749 22.2 22 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000614398153037802 0.00430684025503839 1.59741055629882 0.305882352941176 22.2 22 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000614398153037802 0.00430684025503839 1.59741055629882 0.305882352941176 22.2 22 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0221911348117551 0.0700177047386419 1.5957039210891 0.305555555555556 22.2 22 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0221911348117551 0.0700177047386419 1.5957039210891 0.305555555555556 22.2 22 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000817050800289342 0.00548426079628176 1.59216577492261 0.304878048780488 22.2 22 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00042414355740633 0.00328019718581091 1.58939679096622 0.304347826086957 22.2 22 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.0109861249688704 0.0415778080603793 1.58939679096622 0.304347826086957 22.2 22 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0635951404353019 0.15656727480871 1.58939679096622 0.304347826086957 22.2 22 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0635951404353019 0.15656727480871 1.58939679096622 0.304347826086957 22.2 22 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 5.66122936184069e-09 2.17727821132414e-07 1.58677690614595 0.303846153846154 22.2 22 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.09333094947338e-06 7.79334402268884e-05 1.58652265572035 0.30379746835443 22.2 22 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0302005266637569 0.089718892364355 1.58251628537762 0.303030303030303 22.2 22 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000153042750659999 0.0013279258182267 1.58106443557452 0.302752293577982 22.2 22 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.21057584571176e-05 0.000453912835488472 1.57883601494651 0.302325581395349 22.2 22 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.000747685903525074 0.00504245042993451 1.57883601494651 0.302325581395349 22.2 22 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0148194511148282 0.0532527245868701 1.57883601494651 0.302325581395349 22.2 22 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 8.12820073532002e-06 0.000120483642149587 1.57338638373121 0.301282051282051 22.2 22 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 8.79808487360846e-14 1.1381522522859e-11 1.56903296276678 0.300448430493274 22.2 22 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.00502718161143545 0.0224253273764033 1.56669112252384 0.3 22.2 22 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00995751905255234 0.0385042109015815 1.56669112252384 0.3 22.2 22 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0200262792038555 0.0649143401072582 1.56669112252384 0.3 22.2 22 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0412329761853236 0.113710319983945 1.56669112252384 0.3 22.2 22 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0412329761853236 0.113710319983945 1.56669112252384 0.3 22.2 22 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0884554164323055 0.201073574414011 1.56669112252384 0.3 22.2 22 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0884554164323055 0.201073574414011 1.56669112252384 0.3 22.2 22 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.000682753759354539 0.00467095480558418 1.56669112252384 0.3 22.2 22 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.54302081503929e-26 1.21567186198009e-22 1.56550960584019 0.299773755656109 22.2 22 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.15940407875048e-11 5.49944001353976e-10 1.56389844672612 0.299465240641711 22.2 22 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.74017962412708e-06 4.53404140131725e-05 1.56374066843246 0.299435028248588 22.2 22 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00899947961152842 0.035653573093502 1.54734925681367 0.296296296296296 22.2 22 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.00899947961152842 0.035653573093502 1.54734925681367 0.296296296296296 22.2 22 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0565111691991057 0.144260555999442 1.54734925681367 0.296296296296296 22.2 22 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0565111691991057 0.144260555999442 1.54734925681367 0.296296296296296 22.2 22 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 3.74345550069136e-07 9.86469847682185e-06 1.54295337824318 0.295454545454545 22.2 22 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00109136685848528 0.00678172506386266 1.54295337824318 0.295454545454545 22.2 22 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.0180143948028907 0.0589298478264677 1.54295337824318 0.295454545454545 22.2 22 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 5.10219650327824e-05 0.000533854825306245 1.54039175116253 0.294964028776978 22.2 22 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.00211438330560176 0.0115278446125337 1.53991007769438 0.294871794871795 22.2 22 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.000268460421048287 0.00222104173925415 1.53871449533592 0.294642857142857 22.2 22 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00144548792431821 0.00849970791861492 1.53597168874887 0.294117647058824 22.2 22 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00144548792431821 0.00849970791861492 1.53597168874887 0.294117647058824 22.2 22 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00144548792431821 0.00849970791861492 1.53597168874887 0.294117647058824 22.2 22 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00144548792431821 0.00849970791861492 1.53597168874887 0.294117647058824 22.2 22 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00144548792431821 0.00849970791861492 1.53597168874887 0.294117647058824 22.2 22 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00412403192274878 0.019169022110991 1.53597168874887 0.294117647058824 22.2 22 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.124107178044285 0.261636317565951 1.53597168874887 0.294117647058824 22.2 22 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 5.36960946947596e-15 1.09156489643776e-12 1.53539641845346 0.294007490636704 22.2 22 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 4.32024977437755e-06 6.75573124059259e-05 1.53263261986028 0.293478260869565 22.2 22 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00811565806676641 0.0328084699687744 1.53067523464973 0.293103448275862 22.2 22 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00811565806676641 0.0328084699687744 1.53067523464973 0.293103448275862 22.2 22 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00811565806676641 0.0328084699687744 1.53067523464973 0.293103448275862 22.2 22 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.22805479738757e-05 0.000285632610511938 1.53010173325046 0.292993630573248 22.2 22 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.10609040081037e-05 0.000603400461135636 1.52938895293994 0.292857142857143 22.2 22 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0161672724751564 0.0564982393749927 1.52317192467596 0.291666666666667 22.2 22 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0778088172144741 0.184844652581297 1.52317192467596 0.291666666666667 22.2 22 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0778088172144741 0.184844652581297 1.52317192467596 0.291666666666667 22.2 22 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.0108389177108358 0.0411300797400515 1.51921563396252 0.290909090909091 22.2 22 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0108389177108358 0.0411300797400515 1.51921563396252 0.290909090909091 22.2 22 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.0108389177108358 0.0411300797400515 1.51921563396252 0.290909090909091 22.2 22 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.0017314723590695 0.00981627556556134 1.51811155283318 0.290697674418605 22.2 22 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0500925627634944 0.133236853855051 1.51615269921662 0.290322580645161 22.2 22 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000138536753742297 0.00123178359230488 1.51486673424697 0.290076335877863 22.2 22 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000138536753742297 0.00123178359230488 1.51486673424697 0.290076335877863 22.2 22 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.03724055125678e-06 0.000120389403204615 1.51247048258222 0.289617486338798 22.2 22 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.57144108763777e-05 0.000485459751321534 1.51171950418967 0.289473684210526 22.2 22 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.00336015084322857 0.01695565478693 1.51171950418967 0.289473684210526 22.2 22 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.16351811242058e-05 0.000378292964199536 1.51085517056807 0.289308176100629 22.2 22 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0022895574420931 0.0122944914720697 1.5100637325531 0.289156626506024 22.2 22 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.0217021948610151 0.0689335341232689 1.50866552539333 0.288888888888889 22.2 22 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0217021948610151 0.0689335341232689 1.50866552539333 0.288888888888889 22.2 22 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.000734228443897849 0.00499907691706526 1.50643377165754 0.288461538461538 22.2 22 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.86856052075385e-05 0.000354953184437628 1.50581764332558 0.288343558282209 22.2 22 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.000504344358026249 0.00369939186325439 1.50552900662952 0.288288288288288 22.2 22 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.9864887402334e-05 0.000259337016270838 1.50525225497389 0.288235294117647 22.2 22 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00972962541411458 0.0377696777740944 1.50473158660482 0.288135593220339 22.2 22 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.39285139482418e-06 2.91474637475707e-05 1.49877775547872 0.286995515695067 22.2 22 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.012962202197585 0.0477855277905788 1.49208678335604 0.285714285714286 22.2 22 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.068389258807607 0.167408789816604 1.49208678335604 0.285714285714286 22.2 22 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0443485114999627 0.120263643465492 1.49208678335604 0.285714285714286 22.2 22 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00272496051641253 0.0143723441813265 1.49208678335604 0.285714285714286 22.2 22 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00272496051641253 0.0143723441813265 1.49208678335604 0.285714285714286 22.2 22 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0291648875886336 0.0870055241899909 1.49208678335604 0.285714285714286 22.2 22 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.107743635651094 0.239187509409526 1.49208678335604 0.285714285714286 22.2 22 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.0016742706174568 0.00960680277677836 1.48423369502259 0.284210526315789 22.2 22 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.0016742706174568 0.00960680277677836 1.48423369502259 0.284210526315789 22.2 22 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.0016742706174568 0.00960680277677836 1.48423369502259 0.284210526315789 22.2 22 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.63489812706323e-05 0.000419983461681622 1.4832578674782 0.284023668639053 22.2 22 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00359605569016418 0.0176827949154975 1.4828763711131 0.283950617283951 22.2 22 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00359605569016418 0.0176827949154975 1.4828763711131 0.283950617283951 22.2 22 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.0052919670146153 0.0232421884623382 1.48200511590093 0.283783783783784 22.2 22 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.0052919670146153 0.0232421884623382 1.48200511590093 0.283783783783784 22.2 22 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 0.000335057477189887 0.00272449594309262 1.48033806852647 0.283464566929134 22.2 22 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0259236769397387 0.0788234877889917 1.47586844875435 0.282608695652174 22.2 22 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.0103537752197475 0.0399279732729016 1.4687729273661 0.28125 22.2 22 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0601160668891606 0.15124915312429 1.4687729273661 0.28125 22.2 22 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0601160668891606 0.15124915312429 1.4687729273661 0.28125 22.2 22 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0937163952971231 0.212354188706698 1.46224504768892 0.28 22.2 22 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0937163952971231 0.212354188706698 1.46224504768892 0.28 22.2 22 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 0.000287694771487415 0.00235281413693444 1.45478461377214 0.278571428571429 22.2 22 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00559699898186406 0.0243563594837693 1.45431243441032 0.278481012658228 22.2 22 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.31941369871104e-05 0.000393627141105484 1.45219141481711 0.27807486631016 22.2 22 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0204583297905869 0.0661640983909207 1.45063992826282 0.277777777777778 22.2 22 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0528705794569655 0.139841699939148 1.45063992826282 0.277777777777778 22.2 22 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.0528705794569655 0.139841699939148 1.45063992826282 0.277777777777778 22.2 22 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.150267024493799 0.30855696371526 1.45063992826282 0.277777777777778 22.2 22 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.150267024493799 0.30855696371526 1.45063992826282 0.277777777777778 22.2 22 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.150267024493799 0.30855696371526 1.45063992826282 0.277777777777778 22.2 22 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.43095556097402e-11 1.97039055102063e-09 1.44356363592983 0.276422764227642 22.2 22 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.00736534722301093 0.0304677008672807 1.44300498127196 0.276315789473684 22.2 22 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.0181705915077695 0.0593044764118257 1.44063551496445 0.275862068965517 22.2 22 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0816830754050849 0.193081422427634 1.44063551496445 0.275862068965517 22.2 22 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0465304625973137 0.125166064793908 1.43613352898019 0.275 22.2 22 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.000151392316706659 0.00132166421272132 1.43294919743035 0.274390243902439 22.2 22 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.000923020657242239 0.00602503851034728 1.43192199370459 0.274193548387097 22.2 22 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.000740758237949968 0.00501951891715621 1.42426465683986 0.272727272727273 22.2 22 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00522984200371469 0.0231840036488661 1.42426465683986 0.272727272727273 22.2 22 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.0240656093204935 0.0744464392675266 1.42426465683986 0.272727272727273 22.2 22 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0713343944736869 0.171178487919151 1.42426465683986 0.272727272727273 22.2 22 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0713343944736869 0.171178487919151 1.42426465683986 0.272727272727273 22.2 22 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0713343944736869 0.171178487919151 1.42426465683986 0.272727272727273 22.2 22 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0713343944736869 0.171178487919151 1.42426465683986 0.272727272727273 22.2 22 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.007681223802668 0.0313191446166091 1.41840348541253 0.271604938271605 22.2 22 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0213114161007574 0.0679958410569008 1.41621796386336 0.271186440677966 22.2 22 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0361227546786717 0.101186377771161 1.41437393005625 0.270833333333333 22.2 22 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.22936272979456e-19 2.29769158224883e-16 1.41143344371518 0.27027027027027 22.2 22 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.0188793577179573 0.0614767186101906 1.4091930731696 0.26984126984127 22.2 22 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.38399675476925e-06 2.91474637475707e-05 1.40806141842302 0.26962457337884 22.2 22 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.111285389987375 0.245517999925636 1.40600485354704 0.269230769230769 22.2 22 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.111285389987375 0.245517999925636 1.40600485354704 0.269230769230769 22.2 22 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.054688141118997 0.143053722081494 1.40110588193189 0.268292682926829 22.2 22 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.054688141118997 0.143053722081494 1.40110588193189 0.268292682926829 22.2 22 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.054688141118997 0.143053722081494 1.40110588193189 0.268292682926829 22.2 22 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.054688141118997 0.143053722081494 1.40110588193189 0.268292682926829 22.2 22 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.054688141118997 0.143053722081494 1.40110588193189 0.268292682926829 22.2 22 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.054688141118997 0.143053722081494 1.40110588193189 0.268292682926829 22.2 22 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.0248469379179252 0.0766967302759383 1.39261433113231 0.266666666666667 22.2 22 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0219630790470969 0.0696068184499308 1.38717443140132 0.265625 22.2 22 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0421719099446727 0.116074715379631 1.38550915597347 0.26530612244898 22.2 22 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 4.20799238003285e-14 5.98797315678674e-12 1.38414452566127 0.265044814340589 22.2 22 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0837643451309257 0.197345468743886 1.38237451987398 0.264705882352941 22.2 22 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00241904813484907 0.0129409981048505 1.38110512178411 0.264462809917355 22.2 22 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00919588365571395 0.0358513491563862 1.38060903517427 0.264367816091954 22.2 22 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00919588365571395 0.0358513491563862 1.38060903517427 0.264367816091954 22.2 22 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00919588365571395 0.0358513491563862 1.38060903517427 0.264367816091954 22.2 22 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.2698196880642e-05 0.000172090801534796 1.38060903517427 0.264367816091954 22.2 22 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.037100962250497 0.103316378243556 1.37947646008389 0.264150943396226 22.2 22 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.0171916638435501 0.0564982393749927 1.37810793184968 0.263888888888889 22.2 22 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0729883687559649 0.174265853590164 1.37429045835425 0.263157894736842 22.2 22 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0729883687559649 0.174265853590164 1.37429045835425 0.263157894736842 22.2 22 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.178497795410705 0.342783215748223 1.37429045835425 0.263157894736842 22.2 22 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.178497795410705 0.342783215748223 1.37429045835425 0.263157894736842 22.2 22 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00136347356275823 0.00818659442955677 1.37039176201849 0.26241134751773 22.2 22 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.000863594152162034 0.00568932628947488 1.36378632746237 0.261146496815287 22.2 22 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.152074364910278 0.310922156993284 1.36234010654247 0.260869565217391 22.2 22 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.003586593190984 0.0176827949154975 1.36043206717757 0.260504201680672 22.2 22 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0488966931724027 0.131283008272319 1.357798972854 0.26 22.2 22 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.13045636726327 0.273804440436036 1.35393059971196 0.259259259259259 22.2 22 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.0377341680511074 0.104874455345168 1.35059579527918 0.258620689655172 22.2 22 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.0332095746506984 0.0933937247587822 1.34769128819255 0.258064516129032 22.2 22 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.0332095746506984 0.0933937247587822 1.34769128819255 0.258064516129032 22.2 22 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0258021227437202 0.0786898544129434 1.34287810502044 0.257142857142857 22.2 22 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0258021227437202 0.0786898544129434 1.34287810502044 0.257142857142857 22.2 22 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0974082875416439 0.219670353679492 1.34287810502044 0.257142857142857 22.2 22 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.92057899205874e-05 0.000355212299632444 1.33856882911183 0.256317689530686 22.2 22 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.0177825193545205 0.0583053572384394 1.33741925093499 0.25609756097561 22.2 22 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.0157295638947225 0.0556795259258461 1.3359381664932 0.255813953488372 22.2 22 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.0493659772717975 0.131550160407805 1.3293136797172 0.254545454545455 22.2 22 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0493659772717975 0.131550160407805 1.3293136797172 0.254545454545455 22.2 22 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.0493659772717975 0.131550160407805 1.3293136797172 0.254545454545455 22.2 22 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.00335866726435057 0.01695565478693 1.31470583708295 0.251748251748252 22.2 22 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.0296422084028827 0.0882444823374522 1.30557593543654 0.25 22.2 22 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0336394594646737 0.0944160765645576 1.30557593543654 0.25 22.2 22 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0973233290119987 0.219670353679492 1.30557593543654 0.25 22.2 22 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.112254190236537 0.246118179110858 1.30557593543654 0.25 22.2 22 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.151145403415157 0.309467495050027 1.30557593543654 0.25 22.2 22 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.151145403415157 0.309467495050027 1.30557593543654 0.25 22.2 22 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.208511921736838 0.385340863157819 1.30557593543654 0.25 22.2 22 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.208511921736838 0.385340863157819 1.30557593543654 0.25 22.2 22 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.208511921736838 0.385340863157819 1.30557593543654 0.25 22.2 22 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.0846363994403507 0.198414491603985 1.30557593543654 0.25 22.2 22 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.0846363994403507 0.198414491603985 1.30557593543654 0.25 22.2 22 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 6.04303316582141e-08 1.82962472233274e-06 1.28957062624555 0.246935201401051 22.2 22 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.0493561815266533 0.131550160407805 1.28549015181444 0.246153846153846 22.2 22 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0641846688794363 0.157745740613882 1.28267109446397 0.245614035087719 22.2 22 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 4.97817799142349e-05 0.000524736835688565 1.28154693048985 0.245398773006135 22.2 22 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.084047283444554 0.197684767506777 1.27893152859089 0.244897959183673 22.2 22 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.14871563211595 0.306699050001445 1.2660130283021 0.242424242424242 22.2 22 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0830299417610229 0.195939646975018 1.25722127116111 0.240740740740741 22.2 22 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.095147469846286 0.215254132895493 1.25335289801908 0.24 22.2 22 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.203075806058206 0.381380352765975 1.25335289801908 0.24 22.2 22 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.055139618432525 0.143970049595382 1.25041075506598 0.23943661971831 22.2 22 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.109286387016362 0.241857742961561 1.2488117643306 0.239130434782609 22.2 22 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.109286387016362 0.241857742961561 1.2488117643306 0.239130434782609 22.2 22 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.0627740009641583 0.155082297520829 1.24711731146177 0.238805970149254 22.2 22 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.00752711734233851 0.031046631820718 1.24661444157811 0.238709677419355 22.2 22 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0715625421976854 0.171436864557755 1.2434056527967 0.238095238095238 22.2 22 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.240002011138633 0.437849822884968 1.2434056527967 0.238095238095238 22.2 22 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.23810930841582e-15 3.52365909175143e-13 1.23730501821875 0.23692704970949 22.2 22 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.145434206603469 0.300367018863187 1.23686141251882 0.236842105263158 22.2 22 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.00500847884069986 0.0224253273764033 1.22397743947175 0.234375 22.2 22 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.196637660014682 0.370126177514409 1.21853753974077 0.233333333333333 22.2 22 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.196637660014682 0.370126177514409 1.21853753974077 0.233333333333333 22.2 22 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.196637660014682 0.370126177514409 1.21853753974077 0.233333333333333 22.2 22 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00295180676729882 0.0153300037586358 1.21031932212143 0.231759656652361 22.2 22 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.50784332652323e-06 3.10965370093124e-05 1.2101450350236 0.231726283048211 22.2 22 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.230612930879455 0.421260848063498 1.20514701732603 0.230769230769231 22.2 22 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.102015199575691 0.227892667184 1.19856151449912 0.229508196721311 22.2 22 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.137641554251727 0.288035193676776 1.19677794081683 0.229166666666667 22.2 22 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.189824304519459 0.359202108153177 1.19366942668483 0.228571428571429 22.2 22 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0992950535002793 0.223570982802053 1.18688721403322 0.227272727272727 22.2 22 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.272651770858608 0.480177561796781 1.18688721403322 0.227272727272727 22.2 22 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.133488071541288 0.279754824452509 1.18240839435762 0.226415094339623 22.2 22 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00525846325812302 0.023238488249407 1.16733848344914 0.223529411764706 22.2 22 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.106450514285254 0.23668606535612 1.16051194261026 0.222222222222222 22.2 22 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.106450514285254 0.23668606535612 1.16051194261026 0.222222222222222 22.2 22 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.176144313875126 0.339248297654062 1.16051194261026 0.222222222222222 22.2 22 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.211987194314579 0.38923584194793 1.16051194261026 0.222222222222222 22.2 22 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.259229091912651 0.457671213141071 1.16051194261026 0.222222222222222 22.2 22 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.259229091912651 0.457671213141071 1.16051194261026 0.222222222222222 22.2 22 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.07347218485556 0.175127167587038 1.14890682318415 0.22 22.2 22 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.203152710749549 0.381380352765975 1.14635935794428 0.219512195121951 22.2 22 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.116974854780435 0.254908450769615 1.14461451873888 0.219178082191781 22.2 22 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.163101407423852 0.319748935588077 1.13941172547189 0.218181818181818 22.2 22 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.105490876943249 0.235287645595992 1.12754285333155 0.215909090909091 22.2 22 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.101889743668455 0.227892667184 1.1230760734938 0.21505376344086 22.2 22 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.224230409817575 0.41012837168433 1.11906508751703 0.214285714285714 22.2 22 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.224230409817575 0.41012837168433 1.11906508751703 0.214285714285714 22.2 22 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.214096115597516 0.392601510947507 1.11112845569067 0.212765957446809 22.2 22 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.27310718779636 0.480385078163437 1.10776139976433 0.212121212121212 22.2 22 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.246084808230939 0.445541169734711 1.09304031803989 0.209302325581395 22.2 22 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.340176007169354 0.568157814791068 1.08797994619711 0.208333333333333 22.2 22 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.340176007169354 0.568157814791068 1.08797994619711 0.208333333333333 22.2 22 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.340176007169354 0.568157814791068 1.08797994619711 0.208333333333333 22.2 22 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.318826307137572 0.538824032133926 1.08047663622334 0.206896551724138 22.2 22 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.032118194113706 0.0907307897333853 1.07761823242381 0.206349206349206 22.2 22 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.032118194113706 0.0907307897333853 1.07761823242381 0.206349206349206 22.2 22 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.032118194113706 0.0907307897333853 1.07761823242381 0.206349206349206 22.2 22 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.300175551133502 0.515650817815401 1.07518018212421 0.205882352941176 22.2 22 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.283581223739077 0.4981926930626 1.0712417931787 0.205128205128205 22.2 22 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.255000365652879 0.451325274034884 1.06577627382574 0.204081632653061 22.2 22 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.374451057447141 0.613249857635439 1.04446074834923 0.2 22.2 22 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.374451057447141 0.613249857635439 1.04446074834923 0.2 22.2 22 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.374451057447141 0.613249857635439 1.04446074834923 0.2 22.2 22 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.374451057447141 0.613249857635439 1.04446074834923 0.2 22.2 22 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.159782277775148 0.318514529774731 1.04446074834923 0.2 22.2 22 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.315340781778607 0.534202300560665 1.02175507990686 0.195652173913043 22.2 22 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.124724105482513 0.262547932102982 1.01623207947493 0.194594594594595 22.2 22 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 2.3769694749486e-05 0.000299329872818748 1.01134370023084 0.193658536585366 22.2 22 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.380140176595335 0.614703944653592 1.01076846614442 0.193548387096774 22.2 22 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.380140176595335 0.614703944653592 1.01076846614442 0.193548387096774 22.2 22 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.380140176595335 0.614703944653592 1.01076846614442 0.193548387096774 22.2 22 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.380140176595335 0.614703944653592 1.01076846614442 0.193548387096774 22.2 22 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.380140176595335 0.614703944653592 1.01076846614442 0.193548387096774 22.2 22 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.380140176595335 0.614703944653592 1.01076846614442 0.193548387096774 22.2 22 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.129005304327338 0.271158859760416 1.00734792987997 0.192893401015228 22.2 22 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.320541286527508 0.540438685697445 1.00428918110503 0.192307692307692 22.2 22 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.320541286527508 0.540438685697445 1.00428918110503 0.192307692307692 22.2 22 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.408698230439448 0.637872664377658 1.00428918110503 0.192307692307692 22.2 22 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.408698230439448 0.637872664377658 1.00428918110503 0.192307692307692 22.2 22 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.408698230439448 0.637872664377658 1.00428918110503 0.192307692307692 22.2 22 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.408698230439448 0.637872664377658 1.00428918110503 0.192307692307692 22.2 22 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.360246340574666 0.597471494915793 0.994724522237361 0.19047619047619 22.2 22 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.3838561925988 0.619305399170173 0.988003410600623 0.189189189189189 22.2 22 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.410929194218615 0.639772695156553 0.979181951577403 0.1875 22.2 22 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.410929194218615 0.639772695156553 0.979181951577403 0.1875 22.2 22 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.265679164244649 0.468477634101778 0.976131540513299 0.186915887850467 22.2 22 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.386340405110375 0.621903163429936 0.971591393813237 0.186046511627907 22.2 22 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.442668489195537 0.672332670182014 0.967093285508546 0.185185185185185 22.2 22 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.442668489195537 0.672332670182014 0.967093285508546 0.185185185185185 22.2 22 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.388003755198549 0.623874964573486 0.95919864644317 0.183673469387755 22.2 22 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.322649001024972 0.5433485543888 0.949509771226572 0.181818181818182 22.2 22 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.389093424861042 0.624920929545444 0.949509771226572 0.181818181818182 22.2 22 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.412500254835791 0.641516789761017 0.949509771226572 0.181818181818182 22.2 22 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.441556306756894 0.672332670182014 0.949509771226572 0.181818181818182 22.2 22 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.441556306756894 0.672332670182014 0.949509771226572 0.181818181818182 22.2 22 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.441556306756894 0.672332670182014 0.949509771226572 0.181818181818182 22.2 22 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.441556306756894 0.672332670182014 0.949509771226572 0.181818181818182 22.2 22 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.389767407016058 0.625297655224183 0.941726904249305 0.180327868852459 22.2 22 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.440155965702007 0.672332670182014 0.93733656903136 0.179487179487179 22.2 22 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.440155965702007 0.672332670182014 0.93733656903136 0.179487179487179 22.2 22 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.476138495215682 0.717738430817706 0.932554239597526 0.178571428571429 22.2 22 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.476138495215682 0.717738430817706 0.932554239597526 0.178571428571429 22.2 22 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.476138495215682 0.717738430817706 0.932554239597526 0.178571428571429 22.2 22 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.317220279336119 0.536747274072886 0.923456149455112 0.176829268292683 22.2 22 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.471852182961907 0.713544799526879 0.92158301324932 0.176470588235294 22.2 22 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.471852182961907 0.713544799526879 0.92158301324932 0.176470588235294 22.2 22 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.194831826200652 0.368188165582375 0.91785944551902 0.175757575757576 22.2 22 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.386337835864535 0.621903163429936 0.904651041877286 0.173228346456693 22.2 22 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.508911867731953 0.728552905213853 0.900397196852784 0.172413793103448 22.2 22 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.381821895808206 0.616722539994413 0.897082851342897 0.171779141104294 22.2 22 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.501663662998092 0.72346375052239 0.895252070013625 0.171428571428571 22.2 22 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.48554330836237 0.72346375052239 0.886806295768214 0.169811320754717 22.2 22 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.437168711010809 0.672332670182014 0.87579006849159 0.167701863354037 22.2 22 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.450882340651719 0.683286017835352 0.870383956957691 0.166666666666667 22.2 22 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.515588406880469 0.735889972909637 0.870383956957691 0.166666666666667 22.2 22 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.515588406880469 0.735889972909637 0.870383956957691 0.166666666666667 22.2 22 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.540819547494685 0.766520135542766 0.870383956957691 0.166666666666667 22.2 22 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.505519271369519 0.724424897440912 0.860144145699366 0.164705882352941 22.2 22 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.505519271369519 0.724424897440912 0.860144145699366 0.164705882352941 22.2 22 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.526363027850856 0.749764352984753 0.856115367499369 0.163934426229508 22.2 22 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.494867170039933 0.72346375052239 0.853961618147169 0.163522012578616 22.2 22 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.494867170039933 0.72346375052239 0.853961618147169 0.163522012578616 22.2 22 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.549117607781961 0.769846656033232 0.850142469586582 0.162790697674419 22.2 22 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.526053439117081 0.749764352984753 0.842307055120347 0.161290322580645 22.2 22 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.571719426513791 0.796043780752568 0.842307055120346 0.161290322580645 22.2 22 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.571719426513791 0.796043780752568 0.842307055120346 0.161290322580645 22.2 22 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.548883801011315 0.769846656033232 0.838147514107406 0.160493827160494 22.2 22 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.574927266452641 0.796199787538627 0.82457427501255 0.157894736842105 22.2 22 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.581449530756985 0.796199787538627 0.820647730845823 0.157142857142857 22.2 22 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.601495395457342 0.816725140969273 0.815984959647836 0.15625 22.2 22 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.615356617202387 0.833954729789521 0.806385136593155 0.154411764705882 22.2 22 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.629421398499175 0.850635306068922 0.800499113698315 0.153284671532847 22.2 22 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.62440598217368 0.84541361810956 0.794698395483109 0.152173913043478 22.2 22 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.640398080352886 0.859233358791873 0.79125814268881 0.151515151515152 22.2 22 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.630055947010993 0.850635306068922 0.79125814268881 0.151515151515152 22.2 22 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.630055947010993 0.850635306068922 0.79125814268881 0.151515151515152 22.2 22 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.665253186692842 0.877345027492042 0.789418007473255 0.151162790697674 22.2 22 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.634233974964556 0.855464404146505 0.788272262905079 0.150943396226415 22.2 22 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.7201784419882 0.923543028549489 0.778225655632759 0.149019607843137 22.2 22 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.69586300617892 0.906788514462092 0.772312525187811 0.147887323943662 22.2 22 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.715392579987606 0.92043728871823 0.762380108284109 0.145985401459854 22.2 22 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.676864332888872 0.891262693675214 0.759607816981258 0.145454545454545 22.2 22 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.731073404021284 0.936379346464705 0.705716721857588 0.135135135135135 22.2 22 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.802854701553565 1 0.70300242677352 0.134615384615385 22.2 22 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.751399462104807 0.955221129058246 0.696307165566153 0.133333333333333 22.2 22 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.845238822422214 1 0.684892293999495 0.131147540983607 22.2 22 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.799397411586745 0.999597993574638 0.681170053271237 0.130434782608696 22.2 22 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.845385028186642 1 0.666677073414402 0.127659574468085 22.2 22 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.836547829648711 1 0.661051106550145 0.126582278481013 22.2 22 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.85530025644533 1 0.65965942001004 0.126315789473684 22.2 22 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.80522996705987 1 0.652787967718269 0.125 22.2 22 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.80522996705987 1 0.652787967718269 0.125 22.2 22 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.969512119670093 1 0.629193221897126 0.120481927710843 22.2 22 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.835759539291652 1 0.626676449009538 0.12 22.2 22 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.905955982324759 1 0.594945995895131 0.113924050632911 22.2 22 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999593722623361 1 0.538381829045995 0.103092783505155 22.2 22 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.995698977810938 1 0.505384233072208 0.0967741935483871 22.2 22 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.981240983336753 1 0.484543646141395 0.0927835051546392 22.2 22 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.998820246706445 1 0.481318317211627 0.0921658986175115 22.2 22 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999834659245333 1 0.466277119798763 0.0892857142857143 22.2 22 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999999968 1 0.460404611992733 0.0881612090680101 22.2 22 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.97964244738939 1 0.441321442964463 0.0845070422535211 22.2 22 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999519125388747 1 0.415410524911625 0.0795454545454545 22.2 22 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.993464328908264 1 0.406179179913589 0.0777777777777778 22.2 22 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.387187076693657 0.0741410488245931 22.2 22 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.997634845954551 1 0.386837314203418 0.0740740740740741 22.2 22 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.000670870149933993 0.00252552440041289 3.31109416698437 1 22.3 22 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.000229953527992407 0.000985614067268659 2.89720739611132 0.875 22.3 22 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000872426396998672 0.00317509658038136 2.83808071455803 0.857142857142857 22.3 22 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.000872426396998672 0.00317509658038136 2.83808071455803 0.857142857142857 22.3 22 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 1.84729431592517e-05 9.77211825859299e-05 2.75924513915364 0.833333333333333 22.3 22 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00324752656028367 0.00960754739144214 2.75924513915364 0.833333333333333 22.3 22 3 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00324752656028367 0.00960754739144214 2.75924513915364 0.833333333333333 22.3 22 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00324752656028367 0.00960754739144214 2.75924513915364 0.833333333333333 22.3 22 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00324752656028367 0.00960754739144214 2.75924513915364 0.833333333333333 22.3 22 3 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.00324752656028367 0.00960754739144214 2.75924513915364 0.833333333333333 22.3 22 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00324752656028367 0.00960754739144214 2.75924513915364 0.833333333333333 22.3 22 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000825750693813409 0.00302846195179505 2.57529546321007 0.777777777777778 22.3 22 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.000825750693813409 0.00302846195179505 2.57529546321007 0.777777777777778 22.3 22 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.000825750693813409 0.00302846195179505 2.57529546321007 0.777777777777778 22.3 22 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.000825750693813409 0.00302846195179505 2.57529546321007 0.777777777777778 22.3 22 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000825750693813409 0.00302846195179505 2.57529546321007 0.777777777777778 22.3 22 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000825750693813409 0.00302846195179505 2.57529546321007 0.777777777777778 22.3 22 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.37057230140668e-06 8.4065706245763e-06 2.48332062523828 0.75 22.3 22 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 1.68020516650049e-05 8.92138788033658e-05 2.48332062523828 0.75 22.3 22 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00279984500401747 0.00849505211240267 2.48332062523828 0.75 22.3 22 3 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.00279984500401747 0.00849505211240267 2.48332062523828 0.75 22.3 22 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00279984500401747 0.00849505211240267 2.48332062523828 0.75 22.3 22 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00279984500401747 0.00849505211240267 2.48332062523828 0.75 22.3 22 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.000211711867157669 0.000918493862699279 2.48332062523828 0.75 22.3 22 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 8.49217002988999e-09 7.50581239287792e-08 2.4281357224552 0.733333333333333 22.3 22 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000692019122723767 0.00259142950430505 2.40806848507954 0.727272727272727 22.3 22 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000175088392987661 0.000771364653936351 2.36506726213169 0.714285714285714 22.3 22 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000175088392987661 0.000771364653936351 2.36506726213169 0.714285714285714 22.3 22 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000175088392987661 0.000771364653936351 2.36506726213169 0.714285714285714 22.3 22 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000175088392987661 0.000771364653936351 2.36506726213169 0.714285714285714 22.3 22 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00918527696849618 0.0230354982051198 2.36506726213169 0.714285714285714 22.3 22 3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.00918527696849618 0.0230354982051198 2.36506726213169 0.714285714285714 22.3 22 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.00918527696849618 0.0230354982051198 2.36506726213169 0.714285714285714 22.3 22 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00918527696849618 0.0230354982051198 2.36506726213169 0.714285714285714 22.3 22 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00918527696849618 0.0230354982051198 2.36506726213169 0.714285714285714 22.3 22 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00918527696849618 0.0230354982051198 2.36506726213169 0.714285714285714 22.3 22 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00918527696849618 0.0230354982051198 2.36506726213169 0.714285714285714 22.3 22 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00918527696849618 0.0230354982051198 2.36506726213169 0.714285714285714 22.3 22 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 3.05526020566474e-13 7.62743030291391e-12 2.35597084958503 0.711538461538462 22.3 22 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 9.93981148119412e-07 6.14971814684314e-06 2.34535836828059 0.708333333333333 22.3 22 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 9.93981148119412e-07 6.14971814684314e-06 2.34535836828059 0.708333333333333 22.3 22 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 9.93981148119412e-07 6.14971814684314e-06 2.34535836828059 0.708333333333333 22.3 22 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 4.49912639455926e-05 0.000222300585397841 2.33724294140073 0.705882352941177 22.3 22 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 4.49912639455926e-05 0.000222300585397841 2.33724294140073 0.705882352941177 22.3 22 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.65672855036936e-16 2.00803779611382e-14 2.32270784848157 0.701492537313433 22.3 22 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00219879833301151 0.00692232307052073 2.31776591688906 0.7 22.3 22 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 7.02997728321627e-08 5.65178399661963e-07 2.31776591688906 0.7 22.3 22 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 7.02997728321627e-08 5.65178399661963e-07 2.31776591688906 0.7 22.3 22 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 9.80334651537344e-11 1.43816104034808e-09 2.28097598170034 0.688888888888889 22.3 22 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 3.56392983578583e-05 0.000177946391449938 2.26548548267352 0.684210526315789 22.3 22 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.84908927741456e-14 1.11780694729815e-12 2.25995316159251 0.682539682539683 22.3 22 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 9.27170476613033e-06 5.07447533930903e-05 2.25756420476207 0.681818181818182 22.3 22 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 9.27170476613033e-06 5.07447533930903e-05 2.25756420476207 0.681818181818182 22.3 22 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.43116944863771e-06 1.44148088558811e-05 2.25154403354937 0.68 22.3 22 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.43116944863771e-06 1.44148088558811e-05 2.25154403354937 0.68 22.3 22 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.43116944863771e-06 1.44148088558811e-05 2.25154403354937 0.68 22.3 22 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 4.82933697285901e-27 5.28626654798337e-25 2.24135605149711 0.676923076923077 22.3 22 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.23608915682991e-09 2.97093862591546e-08 2.23498856271445 0.675 22.3 22 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.81494240226574e-15 7.59606776007104e-14 2.22251526277033 0.671232876712329 22.3 22 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 3.54936746916631e-08 2.97102935801392e-07 2.20739611132291 0.666666666666667 22.3 22 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 2.7545046929838e-05 0.000139987863504141 2.20739611132291 0.666666666666667 22.3 22 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.7545046929838e-05 0.000139987863504141 2.20739611132291 0.666666666666667 22.3 22 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 2.7545046929838e-05 0.000139987863504141 2.20739611132291 0.666666666666667 22.3 22 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.7545046929838e-05 0.000139987863504141 2.20739611132291 0.666666666666667 22.3 22 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000106353188516026 0.000494577082543482 2.20739611132291 0.666666666666667 22.3 22 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00674803362442558 0.0178153095501996 2.20739611132291 0.666666666666667 22.3 22 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.00674803362442558 0.0178153095501996 2.20739611132291 0.666666666666667 22.3 22 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00674803362442558 0.0178153095501996 2.20739611132291 0.666666666666667 22.3 22 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00674803362442558 0.0178153095501996 2.20739611132291 0.666666666666667 22.3 22 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 7.19806664252538e-06 4.0168034636524e-05 2.20739611132291 0.666666666666667 22.3 22 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 7.19806664252538e-06 4.0168034636524e-05 2.20739611132291 0.666666666666667 22.3 22 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.000415636657046009 0.00168985989421849 2.20739611132291 0.666666666666667 22.3 22 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000415636657046009 0.00168985989421849 2.20739611132291 0.666666666666667 22.3 22 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000415636657046009 0.00168985989421849 2.20739611132291 0.666666666666667 22.3 22 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00165263363385596 0.00561966204469764 2.20739611132291 0.666666666666667 22.3 22 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00165263363385596 0.00561966204469764 2.20739611132291 0.666666666666667 22.3 22 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00165263363385596 0.00561966204469764 2.20739611132291 0.666666666666667 22.3 22 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00165263363385596 0.00561966204469764 2.20739611132291 0.666666666666667 22.3 22 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 4.12034183586897e-10 5.42893188189031e-09 2.16234721109183 0.653061224489796 22.3 22 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.09148831158971e-05 0.000108619995160298 2.15940923933763 0.652173913043478 22.3 22 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 8.01181222333161e-05 0.000380026959793363 2.15221120853984 0.65 22.3 22 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 2.9418320218185e-07 2.20327735107775e-06 2.142472696284 0.647058823529412 22.3 22 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.16944722977125e-09 1.34203500642297e-08 2.13841498284407 0.645833333333333 22.3 22 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.33131477330017e-09 3.90092463443427e-08 2.13381624094548 0.644444444444444 22.3 22 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00121287358818087 0.00425103230537285 2.12856053591852 0.642857142857143 22.3 22 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00121287358818087 0.00425103230537285 2.12856053591852 0.642857142857143 22.3 22 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.00141073546993e-12 2.28069394238339e-11 2.12503058478101 0.641791044776119 22.3 22 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.56725505427701e-05 8.41586393296675e-05 2.11910026687 0.64 22.3 22 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.22145042007108e-07 1.70871564743845e-06 2.11542127335112 0.638888888888889 22.3 22 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.28334848984045e-09 2.97592668856239e-08 2.11346436190492 0.638297872340426 22.3 22 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.28334848984045e-09 2.97592668856239e-08 2.11346436190492 0.638297872340426 22.3 22 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 7.61879449769358e-13 1.80692409503633e-11 2.11142236735235 0.63768115942029 22.3 22 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 5.95233957163267e-05 0.000290074630494291 2.1070599244446 0.636363636363636 22.3 22 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00483566195101505 0.0132584719774459 2.1070599244446 0.636363636363636 22.3 22 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 3.75421681582729e-11 6.35982205824076e-10 2.09702630575677 0.633333333333333 22.3 22 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 5.05208892748071e-10 6.47668697640094e-09 2.0847629940272 0.62962962962963 22.3 22 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.16267013130926e-05 6.33900228679337e-05 2.0847629940272 0.62962962962963 22.3 22 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.09632981882513e-15 1.81301933304704e-13 2.07905912810646 0.627906976744186 22.3 22 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.85409521243155e-09 1.96893842335082e-08 2.07754928124509 0.627450980392157 22.3 22 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.85409521243155e-09 1.96893842335082e-08 2.07754928124509 0.627450980392157 22.3 22 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.19254813320419e-12 2.61076306699932e-11 2.06943385436523 0.625 22.3 22 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.19254813320419e-12 2.61076306699932e-11 2.06943385436523 0.625 22.3 22 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000877629216449118 0.00317777703564146 2.06943385436523 0.625 22.3 22 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000877629216449118 0.00317777703564146 2.06943385436523 0.625 22.3 22 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0198276635759607 0.0442237700134673 2.06943385436523 0.625 22.3 22 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 7.72442463812326e-11 1.15703750105783e-09 2.06264882533452 0.622950819672131 22.3 22 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 7.72442463812326e-11 1.15703750105783e-09 2.06264882533452 0.622950819672131 22.3 22 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 7.72442463812326e-11 1.15703750105783e-09 2.06264882533452 0.622950819672131 22.3 22 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.86817737072008e-15 1.13372677737074e-13 2.06023637056805 0.622222222222222 22.3 22 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 8.55802882193498e-06 4.72018411380367e-05 2.05516189674892 0.620689655172414 22.3 22 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 5.75206593290921e-11 9.1968424972245e-10 2.04972496051413 0.619047619047619 22.3 22 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.02747460695334e-09 1.19843964401196e-08 2.04685821231761 0.618181818181818 22.3 22 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.02747460695334e-09 1.19843964401196e-08 2.04685821231761 0.618181818181818 22.3 22 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.02747460695334e-09 1.19843964401196e-08 2.04685821231761 0.618181818181818 22.3 22 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.02747460695334e-09 1.19843964401196e-08 2.04685821231761 0.618181818181818 22.3 22 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.02747460695334e-09 1.19843964401196e-08 2.04685821231761 0.618181818181818 22.3 22 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.02747460695334e-09 1.19843964401196e-08 2.04685821231761 0.618181818181818 22.3 22 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.80593986789015e-14 8.49543070639932e-13 2.04055803314153 0.616279069767442 22.3 22 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 3.19507894042245e-05 0.00016065714954845 2.03759641045192 0.615384615384615 22.3 22 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 3.19507894042245e-05 0.00016065714954845 2.03759641045192 0.615384615384615 22.3 22 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.00342368590770626 0.0100039118001355 2.03759641045192 0.615384615384615 22.3 22 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00342368590770626 0.0100039118001355 2.03759641045192 0.615384615384615 22.3 22 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00342368590770626 0.0100039118001355 2.03759641045192 0.615384615384615 22.3 22 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00342368590770626 0.0100039118001355 2.03759641045192 0.615384615384615 22.3 22 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.08379656306983e-14 6.44617936793125e-13 2.03180778428586 0.613636363636364 22.3 22 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00062941434396151 0.00238206545600327 2.02344643537934 0.611111111111111 22.3 22 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00062941434396151 0.00238206545600327 2.02344643537934 0.611111111111111 22.3 22 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 5.61016427291372e-10 7.12791407174663e-09 2.02032864426165 0.610169491525424 22.3 22 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.0034838061037e-31 1.58661939565063e-29 2.01819073035238 0.60952380952381 22.3 22 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.55866512173597e-14 1.58199609364606e-12 2.01710334310542 0.609195402298851 22.3 22 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 4.9699031704974e-08 4.08796081596405e-07 2.01544862338179 0.608695652173913 22.3 22 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000119581081983662 0.000541923183639336 2.01544862338179 0.608695652173913 22.3 22 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000119581081983662 0.000541923183639336 2.01544862338179 0.608695652173913 22.3 22 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.33069317587748e-11 4.19819796110589e-10 2.01544862338179 0.608695652173913 22.3 22 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.33069317587748e-11 4.19819796110589e-10 2.01544862338179 0.608695652173913 22.3 22 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.03109632619658e-09 2.10967158553119e-08 2.01030717281194 0.607142857142857 22.3 22 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 2.31840038420125e-05 0.00011996668169885 2.01030717281194 0.607142857142857 22.3 22 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 7.34535053165588e-09 6.57385773996624e-08 1.99915119516037 0.60377358490566 22.3 22 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 5.39658414343498e-17 2.64804801245102e-15 1.99858837106264 0.603603603603604 22.3 22 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.48897096958233e-09 1.64248503078733e-08 1.99807406628367 0.603448275862069 22.3 22 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.48897096958233e-09 1.64248503078733e-08 1.99807406628367 0.603448275862069 22.3 22 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 8.59317839479696e-05 0.000406248932086248 1.98665650019062 0.6 22.3 22 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000448765317189385 0.00181418479079686 1.98665650019062 0.6 22.3 22 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0135718865615467 0.0314029180115138 1.98665650019062 0.6 22.3 22 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0135718865615467 0.0314029180115138 1.98665650019062 0.6 22.3 22 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.62998950014171e-14 5.15438901933702e-13 1.98665650019062 0.6 22.3 22 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.62998950014171e-14 5.15438901933702e-13 1.98665650019062 0.6 22.3 22 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.62998950014171e-14 5.15438901933702e-13 1.98665650019062 0.6 22.3 22 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.08873205942648e-09 1.2595656264747e-08 1.98665650019062 0.6 22.3 22 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00240872898488316 0.0074351873004094 1.98665650019062 0.6 22.3 22 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00240872898488316 0.0074351873004094 1.98665650019062 0.6 22.3 22 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00240872898488316 0.0074351873004094 1.98665650019062 0.6 22.3 22 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00240872898488316 0.0074351873004094 1.98665650019062 0.6 22.3 22 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00240872898488316 0.0074351873004094 1.98665650019062 0.6 22.3 22 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00240872898488316 0.0074351873004094 1.98665650019062 0.6 22.3 22 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00240872898488316 0.0074351873004094 1.98665650019062 0.6 22.3 22 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 3.30165246273014e-11 5.66054392104216e-10 1.97745901639344 0.597222222222222 22.3 22 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.61765408902287e-10 2.25678604772505e-09 1.97677263700559 0.597014925373134 22.3 22 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.94234277654931e-10 9.82778588785189e-09 1.97597555126487 0.596774193548387 22.3 22 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.93022998297248e-08 1.64474087770649e-07 1.9739215226253 0.596153846153846 22.3 22 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.00972395200389e-12 2.28069394238339e-11 1.97088938510974 0.595238095238095 22.3 22 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.00972395200389e-12 2.28069394238339e-11 1.97088938510974 0.595238095238095 22.3 22 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 4.76397053992485e-07 3.37270153149903e-06 1.97088938510974 0.595238095238095 22.3 22 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 4.92803953155602e-12 9.87690176535805e-11 1.96989146643374 0.594936708860759 22.3 22 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.40840384896006e-11 4.23106009514836e-10 1.9687586938826 0.594594594594595 22.3 22 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.40840384896006e-11 4.23106009514836e-10 1.9687586938826 0.594594594594595 22.3 22 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 5.78186638151457e-10 7.28105828397808e-09 1.96596216164697 0.59375 22.3 22 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.20524542320169e-05 6.52115679549812e-05 1.96596216164697 0.59375 22.3 22 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.40111280883592e-08 1.20107441383946e-07 1.96212987673148 0.592592592592593 22.3 22 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 6.15130993549617e-05 0.000297731770007179 1.96212987673148 0.592592592592593 22.3 22 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 6.15130993549617e-05 0.000297731770007179 1.96212987673148 0.592592592592593 22.3 22 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.753785859618e-11 3.241087374333e-10 1.96051628308285 0.592105263157895 22.3 22 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.93076484278069e-08 5.63570192644396e-07 1.95962716005197 0.591836734693878 22.3 22 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 8.57613946502041e-11 1.27123400611709e-09 1.95867542272315 0.591549295774648 22.3 22 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000318697998546671 0.00132604459629214 1.95655564412713 0.590909090909091 22.3 22 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000318697998546671 0.00132604459629214 1.95655564412713 0.590909090909091 22.3 22 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.24772572565793e-18 1.87063485329984e-16 1.95072214489002 0.589147286821705 22.3 22 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.22851596977921e-11 9.63388937499545e-10 1.95037053671682 0.589041095890411 22.3 22 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.89929403324692e-12 3.91694986856574e-11 1.94770245116728 0.588235294117647 22.3 22 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.89929403324692e-12 3.91694986856574e-11 1.94770245116728 0.588235294117647 22.3 22 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.89929403324692e-12 3.91694986856574e-11 1.94770245116728 0.588235294117647 22.3 22 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00168886258269334 0.00565470930628853 1.94770245116728 0.588235294117647 22.3 22 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00168886258269334 0.00565470930628853 1.94770245116728 0.588235294117647 22.3 22 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00168886258269334 0.00565470930628853 1.94770245116728 0.588235294117647 22.3 22 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00168886258269334 0.00565470930628853 1.94770245116728 0.588235294117647 22.3 22 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00168886258269334 0.00565470930628853 1.94770245116728 0.588235294117647 22.3 22 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 4.39041351204558e-05 0.000218446098868561 1.94098623581842 0.586206896551724 22.3 22 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.58759514278901e-15 1.67388407389456e-13 1.93147159740755 0.583333333333333 22.3 22 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.59604212682267e-10 2.24868113511749e-09 1.93147159740755 0.583333333333333 22.3 22 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 6.19238536573417e-06 3.52470575017589e-05 1.93147159740755 0.583333333333333 22.3 22 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 6.19238536573417e-06 3.52470575017589e-05 1.93147159740755 0.583333333333333 22.3 22 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.78686216404998e-07 1.38945620734597e-06 1.93147159740755 0.583333333333333 22.3 22 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00929190159503779 0.0230354982051198 1.93147159740755 0.583333333333333 22.3 22 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00929190159503779 0.0230354982051198 1.93147159740755 0.583333333333333 22.3 22 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00929190159503779 0.0230354982051198 1.93147159740755 0.583333333333333 22.3 22 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00929190159503779 0.0230354982051198 1.93147159740755 0.583333333333333 22.3 22 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00929190159503779 0.0230354982051198 1.93147159740755 0.583333333333333 22.3 22 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00929190159503779 0.0230354982051198 1.93147159740755 0.583333333333333 22.3 22 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.78512480517486e-29 2.54023259776382e-27 1.93023426774874 0.582959641255605 22.3 22 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.32315954925427e-15 1.2780691996186e-13 1.92645478806363 0.581818181818182 22.3 22 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.28382299946273e-07 1.02060342359523e-06 1.92043461685093 0.58 22.3 22 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00118194069161193 0.00416312278258362 1.9169492545699 0.578947368421053 22.3 22 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00118194069161193 0.00416312278258362 1.9169492545699 0.578947368421053 22.3 22 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 6.35212433935053e-07 4.09080577315583e-06 1.91307662981319 0.577777777777778 22.3 22 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000159542231053077 0.000711688384917016 1.91024663479867 0.576923076923077 22.3 22 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000159542231053077 0.000711688384917016 1.91024663479867 0.576923076923077 22.3 22 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.37903462248764e-22 3.89460391737494e-20 1.90874840214393 0.576470588235294 22.3 22 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 3.1568756351459e-06 1.83356490971944e-05 1.90387914601601 0.575 22.3 22 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 8.04952220221909e-33 1.63635287053682e-30 1.90292768217492 0.574712643678161 22.3 22 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 6.40082851200234e-12 1.24772314692868e-10 1.90292768217492 0.574712643678161 22.3 22 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 6.40082851200234e-12 1.24772314692868e-10 1.90292768217492 0.574712643678161 22.3 22 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.54308491564044e-07 3.24864815826952e-06 1.90211792571442 0.574468085106383 22.3 22 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.09947729631561e-21 9.20327172151245e-20 1.90045049820996 0.57396449704142 22.3 22 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.0368970201831e-36 4.83084076620092e-34 1.89851133124018 0.573378839590444 22.3 22 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.09480121049074e-10 2.78588983413862e-09 1.8983606557377 0.573333333333333 22.3 22 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.09480121049074e-10 2.78588983413862e-09 1.8983606557377 0.573333333333333 22.3 22 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.09480121049074e-10 2.78588983413862e-09 1.8983606557377 0.573333333333333 22.3 22 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.09480121049074e-10 2.78588983413862e-09 1.8983606557377 0.573333333333333 22.3 22 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.09480121049074e-10 2.78588983413862e-09 1.8983606557377 0.573333333333333 22.3 22 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.10219201630569e-11 5.38343809658903e-10 1.89782226644226 0.573170731707317 22.3 22 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.65998973301655e-17 1.92895014447502e-15 1.89205380970535 0.571428571428571 22.3 22 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.01810810572508e-09 1.19843964401196e-08 1.89205380970535 0.571428571428571 22.3 22 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000112618560038894 0.000515293282750308 1.89205380970535 0.571428571428571 22.3 22 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000112618560038894 0.000515293282750308 1.89205380970535 0.571428571428571 22.3 22 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000112618560038894 0.000515293282750308 1.89205380970535 0.571428571428571 22.3 22 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00637143566707345 0.0169785635847294 1.89205380970535 0.571428571428571 22.3 22 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00637143566707345 0.0169785635847294 1.89205380970535 0.571428571428571 22.3 22 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00637143566707345 0.0169785635847294 1.89205380970535 0.571428571428571 22.3 22 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00637143566707345 0.0169785635847294 1.89205380970535 0.571428571428571 22.3 22 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.32180428516066e-20 9.40463748891806e-19 1.88915188668433 0.570552147239264 22.3 22 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.88321423677491e-15 2.7360521607148e-13 1.8879045688946 0.570175438596491 22.3 22 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 3.54180630296461e-13 8.68963856744594e-12 1.88732367518109 0.57 22.3 22 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.37873397160742e-12 4.83562634513909e-11 1.88696764355023 0.56989247311828 22.3 22 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.60079435650488e-06 9.7765251901564e-06 1.88130350396839 0.568181818181818 22.3 22 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 4.36990220979477e-16 1.94324088891811e-14 1.87715574821161 0.566929133858268 22.3 22 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 5.54252701232578e-11 8.9625181119768e-10 1.87495693793091 0.566265060240964 22.3 22 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.53262714960267e-09 2.38670757210901e-08 1.87148800742595 0.565217391304348 22.3 22 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.30748074475248e-21 1.03363616654598e-19 1.87067467061264 0.564971751412429 22.3 22 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.22772216801783e-08 1.06527356407888e-07 1.86249046892871 0.5625 22.3 22 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00437728583001264 0.012237480817501 1.86249046892871 0.5625 22.3 22 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.99874384182712e-19 1.2928238576909e-17 1.86249046892871 0.5625 22.3 22 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 5.61108490709711e-06 3.21958621887064e-05 1.85744306928391 0.560975609756098 22.3 22 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 5.61108490709711e-06 3.21958621887064e-05 1.85744306928391 0.560975609756098 22.3 22 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.30779046654912e-13 5.97088333436255e-12 1.85668831793516 0.560747663551402 22.3 22 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000403604673370762 0.00165512809857808 1.85421273351125 0.56 22.3 22 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000403604673370762 0.00165512809857808 1.85421273351125 0.56 22.3 22 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 9.01842420712523e-15 3.05552801112838e-13 1.84552789635194 0.557377049180328 22.3 22 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.68202214218998e-10 6.05683409848758e-09 1.84415371325712 0.556962025316456 22.3 22 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.68202214218998e-10 6.05683409848758e-09 1.84415371325712 0.556962025316456 22.3 22 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.035778939138e-47 4.9130447679779e-45 1.84208759994201 0.556338028169014 22.3 22 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00301317288110814 0.00902683159961449 1.83949675943576 0.555555555555556 22.3 22 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00301317288110814 0.00902683159961449 1.83949675943576 0.555555555555556 22.3 22 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00301317288110814 0.00902683159961449 1.83949675943576 0.555555555555556 22.3 22 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0361772010153796 0.0745860959298819 1.83949675943576 0.555555555555556 22.3 22 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0361772010153796 0.0745860959298819 1.83949675943576 0.555555555555556 22.3 22 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0361772010153796 0.0745860959298819 1.83949675943576 0.555555555555556 22.3 22 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0361772010153796 0.0745860959298819 1.83949675943576 0.555555555555556 22.3 22 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000282078645675722 0.00119463664522783 1.83949675943576 0.555555555555556 22.3 22 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 3.06629237317795e-14 9.09027926465048e-13 1.83640516824343 0.554621848739496 22.3 22 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.86693076464303e-13 7.28507585372684e-12 1.83615221987315 0.554545454545455 22.3 22 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.15399303390382e-29 3.74011007270428e-27 1.83383676940673 0.553846153846154 22.3 22 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.59734373466329e-09 1.72198495032262e-08 1.82981519754399 0.552631578947368 22.3 22 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.37543558149338e-05 7.41380618357986e-05 1.8211017918414 0.55 22.3 22 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00207804392701728 0.00670534355588568 1.8211017918414 0.55 22.3 22 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00207804392701728 0.00670534355588568 1.8211017918414 0.55 22.3 22 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.64196965135995e-09 6.79657675867825e-08 1.81877003538578 0.549295774647887 22.3 22 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 5.15767993095937e-08 4.21803364468689e-07 1.81075462256958 0.546875 22.3 22 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 6.81333666636236e-06 3.83216524752318e-05 1.80605136380966 0.545454545454545 22.3 22 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 6.81333666636236e-06 3.83216524752318e-05 1.80605136380966 0.545454545454545 22.3 22 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00143561287915186 0.00494643372162976 1.80605136380966 0.545454545454545 22.3 22 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00143561287915186 0.00494643372162976 1.80605136380966 0.545454545454545 22.3 22 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0240553560941847 0.0521016312359586 1.80605136380966 0.545454545454545 22.3 22 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.93226037523701e-09 2.02176949556049e-08 1.80224112886491 0.544303797468354 22.3 22 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.42080780455335e-54 1.01090475293971e-51 1.80032876759987 0.543726235741445 22.3 22 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.36946826589166e-09 1.53445145068019e-08 1.79861905367052 0.54320987654321 22.3 22 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.36946826589166e-09 1.53445145068019e-08 1.79861905367052 0.54320987654321 22.3 22 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 6.74988911943584e-05 0.000324496358680986 1.79745111922009 0.542857142857143 22.3 22 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000993363422096731 0.0035516486171951 1.79350934044987 0.541666666666667 22.3 22 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000993363422096731 0.0035516486171951 1.79350934044987 0.541666666666667 22.3 22 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000993363422096731 0.0035516486171951 1.79350934044987 0.541666666666667 22.3 22 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4.72525210440812e-05 0.000232665527493867 1.78978063080236 0.540540540540541 22.3 22 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.07344074671546e-13 2.8287151529187e-12 1.78905894506413 0.540322580645161 22.3 22 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.07344074671546e-13 2.8287151529187e-12 1.78905894506413 0.540322580645161 22.3 22 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.07344074671546e-13 2.8287151529187e-12 1.78905894506413 0.540322580645161 22.3 22 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000688344189408061 0.00258446908054794 1.78289685914543 0.538461538461538 22.3 22 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0161381532302579 0.0369800193988034 1.78289685914543 0.538461538461538 22.3 22 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0161381532302579 0.0369800193988034 1.78289685914543 0.538461538461538 22.3 22 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0161381532302579 0.0369800193988034 1.78289685914543 0.538461538461538 22.3 22 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0161381532302579 0.0369800193988034 1.78289685914543 0.538461538461538 22.3 22 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 8.68183608949559e-08 6.94059143559114e-07 1.78289685914543 0.538461538461538 22.3 22 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 6.14025871652643e-11 9.60174522375506e-10 1.77260596818355 0.535353535353535 22.3 22 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.11003888928933e-07 2.95383097952461e-06 1.76591688905833 0.533333333333333 22.3 22 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.11003888928933e-07 2.95383097952461e-06 1.76591688905833 0.533333333333333 22.3 22 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.11003888928933e-07 2.95383097952461e-06 1.76591688905833 0.533333333333333 22.3 22 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.11003888928933e-07 2.95383097952461e-06 1.76591688905833 0.533333333333333 22.3 22 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.11003888928933e-07 2.95383097952461e-06 1.76591688905833 0.533333333333333 22.3 22 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.11003888928933e-07 2.95383097952461e-06 1.76591688905833 0.533333333333333 22.3 22 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.11003888928933e-07 2.95383097952461e-06 1.76591688905833 0.533333333333333 22.3 22 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0109002433038624 0.0267893717122558 1.76591688905833 0.533333333333333 22.3 22 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0109002433038624 0.0267893717122558 1.76591688905833 0.533333333333333 22.3 22 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0109002433038624 0.0267893717122558 1.76591688905833 0.533333333333333 22.3 22 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.8945792806659e-07 2.19090677346126e-06 1.76235657274974 0.532258064516129 22.3 22 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000230736736395648 0.000986001128801821 1.75901877621045 0.53125 22.3 22 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 5.60468059366123e-06 3.21958621887064e-05 1.75690710901211 0.530612244897959 22.3 22 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.67026559008837e-09 2.48352152594494e-08 1.75293220605055 0.529411764705882 22.3 22 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.67026559008837e-09 2.48352152594494e-08 1.75293220605055 0.529411764705882 22.3 22 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00740176198324683 0.0194330393028787 1.75293220605055 0.529411764705882 22.3 22 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 5.05678983425503e-11 8.27104820016657e-10 1.75105941523212 0.528846153846154 22.3 22 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.76109852094956e-06 1.62357156831042e-05 1.74925729576533 0.528301886792453 22.3 22 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000111915410810977 0.000515293282750308 1.74752192146397 0.527777777777778 22.3 22 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00504787531388169 0.0137871911164178 1.74268114051809 0.526315789473684 22.3 22 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 9.56750439219716e-07 5.99760297361082e-06 1.73972744366975 0.525423728813559 22.3 22 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 9.56750439219716e-07 5.99760297361082e-06 1.73972744366975 0.525423728813559 22.3 22 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 6.06109133646971e-14 1.69116332780321e-12 1.73891995820042 0.525179856115108 22.3 22 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.23941995986435e-08 1.0689058199315e-07 1.73832443766679 0.525 22.3 22 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 4.72596904693997e-07 3.36252697689779e-06 1.73438265889657 0.523809523809524 22.3 22 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00345486700803236 0.0100743355582583 1.73438265889657 0.523809523809524 22.3 22 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 4.10101724453999e-11 6.86558533997695e-10 1.73148961025788 0.522935779816514 22.3 22 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.33653990428238e-07 1.7780194030983e-06 1.72967605737989 0.522388059701492 22.3 22 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.33653990428238e-07 1.7780194030983e-06 1.72967605737989 0.522388059701492 22.3 22 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.8586540526657e-05 9.79579524793809e-05 1.72752739147011 0.521739130434783 22.3 22 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00237168148541361 0.00743370650604309 1.72752739147011 0.521739130434783 22.3 22 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.64342147156924e-07 1.28493887584782e-06 1.72752739147011 0.521739130434783 22.3 22 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00112586092881212 0.00399526209900161 1.71686364214004 0.518518518518518 22.3 22 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00112586092881212 0.00399526209900161 1.71686364214004 0.518518518518518 22.3 22 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00112586092881212 0.00399526209900161 1.71686364214004 0.518518518518518 22.3 22 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 3.1309576669848e-06 1.82596424595056e-05 1.71467376504548 0.517857142857143 22.3 22 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.19552163040313e-06 1.32382511867104e-05 1.71263491395743 0.517241379310345 22.3 22 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.19552163040313e-06 1.32382511867104e-05 1.71263491395743 0.517241379310345 22.3 22 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000778058821339327 0.00289837094964886 1.71263491395743 0.517241379310345 22.3 22 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000778058821339327 0.00289837094964886 1.71263491395743 0.517241379310345 22.3 22 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000259223694822887 0.0011011203514417 1.70284842873482 0.514285714285714 22.3 22 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000259223694822887 0.0011011203514417 1.70284842873482 0.514285714285714 22.3 22 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.0584495263265e-16 4.85862476116971e-15 1.70078061036356 0.513661202185792 22.3 22 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 8.73098407057454e-05 0.000408690471461433 1.69592628065053 0.51219512195122 22.3 22 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 8.73098407057454e-05 0.000408690471461433 1.69592628065053 0.51219512195122 22.3 22 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 8.73098407057454e-05 0.000408690471461433 1.69592628065053 0.51219512195122 22.3 22 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.91731505509795e-09 2.02099209141065e-08 1.68933375866549 0.510204081632653 22.3 22 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.35065808862981e-09 1.53445145068019e-08 1.68865802516203 0.51 22.3 22 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.90991834282626e-07 2.19090677346126e-06 1.67822581066331 0.506849315068493 22.3 22 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.04419485834679e-07 1.58091808881929e-06 1.67762104460541 0.506666666666667 22.3 22 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.09875373921395e-18 6.79794161261501e-17 1.67059751152393 0.504545454545455 22.3 22 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00257619327702501 0.00793489834027401 1.65554708349218 0.5 22.3 22 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.13394804149968e-17 1.16792617809771e-15 1.65554708349218 0.5 22.3 22 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.43949749252921e-07 4.09080577315583e-06 1.65554708349218 0.5 22.3 22 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 3.23199426195903e-05 0.000161941120942524 1.65554708349218 0.5 22.3 22 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 6.63352657350537e-05 0.000319983332681293 1.65554708349218 0.5 22.3 22 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00801770670074611 0.0207063459803298 1.65554708349218 0.5 22.3 22 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00801770670074611 0.0207063459803298 1.65554708349218 0.5 22.3 22 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00801770670074611 0.0207063459803298 1.65554708349218 0.5 22.3 22 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00801770670074611 0.0207063459803298 1.65554708349218 0.5 22.3 22 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00801770670074611 0.0207063459803298 1.65554708349218 0.5 22.3 22 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00801770670074611 0.0207063459803298 1.65554708349218 0.5 22.3 22 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00801770670074611 0.0207063459803298 1.65554708349218 0.5 22.3 22 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00801770670074611 0.0207063459803298 1.65554708349218 0.5 22.3 22 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0117903510853855 0.0281504523397712 1.65554708349218 0.5 22.3 22 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0117903510853855 0.0281504523397712 1.65554708349218 0.5 22.3 22 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0174232007777121 0.039605774291828 1.65554708349218 0.5 22.3 22 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0174232007777121 0.039605774291828 1.65554708349218 0.5 22.3 22 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0174232007777121 0.039605774291828 1.65554708349218 0.5 22.3 22 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0587825154692125 0.110791416573099 1.65554708349218 0.5 22.3 22 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000586195341223564 0.00233004461050595 1.65554708349218 0.5 22.3 22 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.000586195341223564 0.00233004461050595 1.65554708349218 0.5 22.3 22 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000586195341223564 0.00233004461050595 1.65554708349218 0.5 22.3 22 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000586195341223564 0.00233004461050595 1.65554708349218 0.5 22.3 22 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00177411234390603 0.00591232286973835 1.65554708349218 0.5 22.3 22 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00374999954873048 0.0108903048119254 1.65554708349218 0.5 22.3 22 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00547412113691285 0.0148657907973797 1.65554708349218 0.5 22.3 22 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00547412113691285 0.0148657907973797 1.65554708349218 0.5 22.3 22 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0259048707934423 0.0549481637427063 1.65554708349218 0.5 22.3 22 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0259048707934423 0.0549481637427063 1.65554708349218 0.5 22.3 22 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0259048707934423 0.0549481637427063 1.65554708349218 0.5 22.3 22 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0259048707934423 0.0549481637427063 1.65554708349218 0.5 22.3 22 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0259048707934423 0.0549481637427063 1.65554708349218 0.5 22.3 22 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0259048707934423 0.0549481637427063 1.65554708349218 0.5 22.3 22 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0259048707934423 0.0549481637427063 1.65554708349218 0.5 22.3 22 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0388188105933316 0.0786882727554286 1.65554708349218 0.5 22.3 22 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0388188105933316 0.0786882727554286 1.65554708349218 0.5 22.3 22 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0388188105933316 0.0786882727554286 1.65554708349218 0.5 22.3 22 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0388188105933316 0.0786882727554286 1.65554708349218 0.5 22.3 22 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0388188105933316 0.0786882727554286 1.65554708349218 0.5 22.3 22 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.49530147092806e-09 2.38670757210901e-08 1.64007468084273 0.495327102803738 22.3 22 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.01460507936498e-08 8.91224091318742e-08 1.63882438567913 0.494949494949495 22.3 22 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.86795961020456e-12 3.91694986856574e-11 1.62350423671492 0.490322580645161 22.3 22 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 4.94746893042105e-05 0.000242767182344454 1.62308537597273 0.490196078431373 22.3 22 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.54675840004513e-20 1.04811295393535e-18 1.6190276625328 0.488970588235294 22.3 22 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000208862132777634 0.000909240109310933 1.61704598852725 0.488372093023256 22.3 22 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000208862132777634 0.000909240109310933 1.61704598852725 0.488372093023256 22.3 22 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000300016136885825 0.00125565577290744 1.61516788633384 0.48780487804878 22.3 22 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000300016136885825 0.00125565577290744 1.61516788633384 0.48780487804878 22.3 22 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000300016136885825 0.00125565577290744 1.61516788633384 0.48780487804878 22.3 22 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000300016136885825 0.00125565577290744 1.61516788633384 0.48780487804878 22.3 22 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.04983377284199e-06 6.46715783010456e-06 1.61198005497923 0.486842105263158 22.3 22 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000620979521932581 0.00236271085483974 1.61080256772213 0.486486486486487 22.3 22 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000620979521932581 0.00236271085483974 1.61080256772213 0.486486486486487 22.3 22 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00129172629095736 0.00450521203929493 1.60537899005303 0.484848484848485 22.3 22 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00186719558063755 0.0061935182080355 1.6021423388634 0.483870967741935 22.3 22 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 5.46366345826656e-07 3.82994734044991e-06 1.59570803228162 0.481927710843373 22.3 22 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 5.20222996164257e-05 0.000254390832832212 1.59423052484433 0.481481481481481 22.3 22 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00392293045750841 0.0113461992703953 1.59423052484433 0.481481481481481 22.3 22 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00392293045750841 0.0113461992703953 1.59423052484433 0.481481481481481 22.3 22 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.36213257793474e-15 9.60375616686039e-14 1.59247862316867 0.480952380952381 22.3 22 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.5692651894302e-09 1.70586180912078e-08 1.58824842156161 0.479674796747967 22.3 22 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000218138931341731 0.000943500605772899 1.58356677551426 0.478260869565217 22.3 22 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00831802415078712 0.0213871159391812 1.58356677551426 0.478260869565217 22.3 22 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000448591467361345 0.00181418479079686 1.57671150808779 0.476190476190476 22.3 22 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0121657427850314 0.0288465913044163 1.57671150808779 0.476190476190476 22.3 22 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.47552895032527e-13 1.07943689768015e-11 1.57412673512372 0.475409836065574 22.3 22 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000925792843541851 0.00334366298568542 1.56841302646628 0.473684210526316 22.3 22 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 5.96673416011514e-56 8.49066270984384e-53 1.55816196093382 0.470588235294118 22.3 22 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00191886491294296 0.00628975007133788 1.55816196093382 0.470588235294118 22.3 22 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.000156986272403392 0.000704704938895983 1.55816196093382 0.470588235294118 22.3 22 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.59912769287975e-21 2.69555721419362e-19 1.55397977775647 0.469325153374233 22.3 22 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.28642806271932e-18 1.87063485329984e-16 1.55394311085909 0.469314079422383 22.3 22 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 2.39224385351046e-06 1.43635569769847e-05 1.55335281907909 0.469135802469136 22.3 22 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.85311459881569e-11 9.25442452679414e-10 1.55076562251167 0.468354430379747 22.3 22 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00399826454708715 0.0114018646302706 1.54517727792604 0.466666666666667 22.3 22 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.00399826454708715 0.0114018646302706 1.54517727792604 0.466666666666667 22.3 22 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0390339198468249 0.0790117609417237 1.54517727792604 0.466666666666667 22.3 22 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.000227796436880929 0.000979318216560609 1.52819730783894 0.461538461538462 22.3 22 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.000227796436880929 0.000979318216560609 1.52819730783894 0.461538461538462 22.3 22 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0083865148939305 0.0213871159391812 1.52819730783894 0.461538461538462 22.3 22 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0083865148939305 0.0213871159391812 1.52819730783894 0.461538461538462 22.3 22 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0083865148939305 0.0213871159391812 1.52819730783894 0.461538461538462 22.3 22 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0083865148939305 0.0213871159391812 1.52819730783894 0.461538461538462 22.3 22 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0083865148939305 0.0213871159391812 1.52819730783894 0.461538461538462 22.3 22 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0582593740473949 0.110791416573099 1.52819730783894 0.461538461538462 22.3 22 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0582593740473949 0.110791416573099 1.52819730783894 0.461538461538462 22.3 22 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0582593740473949 0.110791416573099 1.52819730783894 0.461538461538462 22.3 22 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0582593740473949 0.110791416573099 1.52819730783894 0.461538461538462 22.3 22 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0582593740473949 0.110791416573099 1.52819730783894 0.461538461538462 22.3 22 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00193646717213298 0.00630570431566414 1.52131353618201 0.459459459459459 22.3 22 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0121832757371428 0.0288465913044163 1.5175848265345 0.458333333333333 22.3 22 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0121832757371428 0.0288465913044163 1.5175848265345 0.458333333333333 22.3 22 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000113251110262131 0.000516526698407092 1.51524648319624 0.457627118644068 22.3 22 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.66183889974553e-11 3.11157467676039e-10 1.50504280317471 0.454545454545455 22.3 22 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.003997908495912 0.0114018646302706 1.50504280317471 0.454545454545455 22.3 22 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.003997908495912 0.0114018646302706 1.50504280317471 0.454545454545455 22.3 22 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0877218149484025 0.155258883919872 1.50504280317471 0.454545454545455 22.3 22 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0877218149484025 0.155258883919872 1.50504280317471 0.454545454545455 22.3 22 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0877218149484025 0.155258883919872 1.50504280317471 0.454545454545455 22.3 22 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0877218149484025 0.155258883919872 1.50504280317471 0.454545454545455 22.3 22 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 7.99512641858895e-05 0.000380026959793363 1.50033954441479 0.453125 22.3 22 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.18879251453047e-11 2.28601587591467e-10 1.50033954441479 0.453125 22.3 22 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 6.96506004204623e-10 8.69410564897525e-09 1.49936339637028 0.452830188679245 22.3 22 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00134834326070007 0.00467973770725901 1.49787593268341 0.452380952380952 22.3 22 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00575326251945742 0.0154761674200149 1.49533284960584 0.451612903225806 22.3 22 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00575326251945742 0.0154761674200149 1.49533284960584 0.451612903225806 22.3 22 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.32050457243174e-29 3.00188909688215e-27 1.49433276075512 0.451310861423221 22.3 22 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 4.62581204335842e-11 7.65410527639422e-10 1.49359139054186 0.451086956521739 22.3 22 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00192674747430496 0.00628975007133788 1.48999237514297 0.45 22.3 22 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0259102022989149 0.0549481637427063 1.48999237514297 0.45 22.3 22 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.05804768468054e-08 9.23682119816204e-08 1.48999237514297 0.45 22.3 22 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000658103874576552 0.00248403664064306 1.48661370762563 0.448979591836735 22.3 22 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00275463210480196 0.00842976663469504 1.48127896944038 0.447368421052632 22.3 22 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 4.11676985755319e-08 3.40590901587104e-07 1.47995875645513 0.446969696969697 22.3 22 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.60938404832535e-07 1.26527817721932e-06 1.47767838857154 0.446280991735537 22.3 22 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.60938404832535e-07 1.26527817721932e-06 1.47767838857154 0.446280991735537 22.3 22 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000112552396778974 0.000515293282750308 1.47725739757764 0.446153846153846 22.3 22 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.69784576151778e-09 2.49287955755831e-08 1.47628402349622 0.445859872611465 22.3 22 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00394027448467815 0.0113579153948986 1.47159740754861 0.444444444444444 22.3 22 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0379637826027177 0.0775071200052616 1.47159740754861 0.444444444444444 22.3 22 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0379637826027177 0.0775071200052616 1.47159740754861 0.444444444444444 22.3 22 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 1.96786800725019e-05 0.000102594598609716 1.47159740754861 0.444444444444444 22.3 22 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0119573824430681 0.0285014325234271 1.47159740754861 0.444444444444444 22.3 22 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.65622996971233e-23 2.69986803350046e-21 1.46994763467019 0.443946188340807 22.3 22 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0056392586929928 0.0152270685391437 1.46077683837546 0.441176470588235 22.3 22 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0056392586929928 0.0152270685391437 1.46077683837546 0.441176470588235 22.3 22 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0056392586929928 0.0152270685391437 1.46077683837546 0.441176470588235 22.3 22 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 3.99419836297532e-08 3.32382705878005e-07 1.45594211597894 0.439716312056738 22.3 22 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 1.7226922390358e-06 1.04760301544784e-05 1.45440584904921 0.439252336448598 22.3 22 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00269795730743866 0.00827412338035605 1.45365109770045 0.439024390243902 22.3 22 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0558422569005792 0.107383150769627 1.44860369805566 0.4375 22.3 22 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0558422569005792 0.107383150769627 1.44860369805566 0.4375 22.3 22 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0558422569005792 0.107383150769627 1.44860369805566 0.4375 22.3 22 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.51130909132595e-11 2.86745711594244e-10 1.44025172285867 0.434977578475336 22.3 22 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0249913787797529 0.0538014099903002 1.43960615955842 0.434782608695652 22.3 22 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0249913787797529 0.0538014099903002 1.43960615955842 0.434782608695652 22.3 22 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.70779901221123e-08 2.27999881324058e-07 1.43771194092742 0.434210526315789 22.3 22 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0115700442410175 0.0281504523397712 1.43480747235989 0.433333333333333 22.3 22 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.000148992225375532 0.000670936508573993 1.42560998856271 0.430555555555556 22.3 22 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000208939926735541 0.000909240109310933 1.41904035727902 0.428571428571429 22.3 22 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00778290370163941 0.0203960809713313 1.41904035727902 0.428571428571429 22.3 22 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0362185469343277 0.0745860959298819 1.41904035727902 0.428571428571429 22.3 22 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0362185469343277 0.0745860959298819 1.41904035727902 0.428571428571429 22.3 22 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0165864896583963 0.0378853527831428 1.41904035727902 0.428571428571429 22.3 22 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0165864896583963 0.0378853527831428 1.41904035727902 0.428571428571429 22.3 22 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0825252514878589 0.15036291020131 1.41904035727902 0.428571428571429 22.3 22 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0825252514878589 0.15036291020131 1.41904035727902 0.428571428571429 22.3 22 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0825252514878589 0.15036291020131 1.41904035727902 0.428571428571429 22.3 22 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0825252514878589 0.15036291020131 1.41904035727902 0.428571428571429 22.3 22 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0825252514878589 0.15036291020131 1.41904035727902 0.428571428571429 22.3 22 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0825252514878589 0.15036291020131 1.41904035727902 0.428571428571429 22.3 22 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.57039983833325e-09 1.70586180912078e-08 1.41411313381624 0.427083333333333 22.3 22 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.44144806221379e-08 2.06796463841085e-07 1.41327190054211 0.426829268292683 22.3 22 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000596847585036017 0.00236271085483974 1.41128603838678 0.426229508196721 22.3 22 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 7.41448815430873e-17 3.51693888119377e-15 1.40765768061635 0.425133689839572 22.3 22 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.70828215133695e-07 2.76276727819502e-06 1.40542845936747 0.424460431654676 22.3 22 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0110796398172699 0.0271365360756886 1.4047066162964 0.424242424242424 22.3 22 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0110796398172699 0.0271365360756886 1.4047066162964 0.424242424242424 22.3 22 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0237905958535473 0.0521016312359586 1.40084753218569 0.423076923076923 22.3 22 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0237905958535473 0.0521016312359586 1.40084753218569 0.423076923076923 22.3 22 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.96734576087528e-07 3.49927377115125e-06 1.3953896846577 0.421428571428571 22.3 22 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0525857486557932 0.10278780266098 1.39414491241447 0.421052631578947 22.3 22 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0525857486557932 0.10278780266098 1.39414491241447 0.421052631578947 22.3 22 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.74108956258773e-32 6.65446305945293e-30 1.39057475898959 0.419974391805378 22.3 22 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.73633868729e-06 1.61568877676916e-05 1.38852336034828 0.419354838709677 22.3 22 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.69014845791662e-40 7.65616251123069e-38 1.38542278458405 0.418418418418418 22.3 22 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00164563023635138 0.00561966204469764 1.38463937892074 0.418181818181818 22.3 22 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00339470859483522 0.0100013878477236 1.37962256957682 0.416666666666667 22.3 22 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.122652532344882 0.209777107604287 1.37962256957682 0.416666666666667 22.3 22 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.122652532344882 0.209777107604287 1.37962256957682 0.416666666666667 22.3 22 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.122652532344882 0.209777107604287 1.37962256957682 0.416666666666667 22.3 22 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.122652532344882 0.209777107604287 1.37962256957682 0.416666666666667 22.3 22 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.122652532344882 0.209777107604287 1.37962256957682 0.416666666666667 22.3 22 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00706585460229764 0.0186081761831898 1.37289270338376 0.414634146341463 22.3 22 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0224435837417484 0.0499799994749734 1.37010793116595 0.413793103448276 22.3 22 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00476322360118338 0.0132584719774459 1.3676258515805 0.41304347826087 22.3 22 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.23631003408253e-10 1.75926917849944e-09 1.36648330700942 0.412698412698413 22.3 22 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.23631003408253e-10 1.75926917849944e-09 1.36648330700942 0.412698412698413 22.3 22 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.23631003408253e-10 1.75926917849944e-09 1.36648330700942 0.412698412698413 22.3 22 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0148879066042638 0.0343920310030316 1.36339171581709 0.411764705882353 22.3 22 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0765000342700297 0.140645411842703 1.36339171581709 0.411764705882353 22.3 22 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0765000342700297 0.140645411842703 1.36339171581709 0.411764705882353 22.3 22 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0765000342700297 0.140645411842703 1.36339171581709 0.411764705882353 22.3 22 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0765000342700297 0.140645411842703 1.36339171581709 0.411764705882353 22.3 22 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0765000342700297 0.140645411842703 1.36339171581709 0.411764705882353 22.3 22 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.9103444402731e-05 0.00010031070621803 1.35991367572572 0.410714285714286 22.3 22 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 6.30843027299018e-06 3.57645270058368e-05 1.35572359593061 0.409448818897638 22.3 22 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0319259300732516 0.0666137807833388 1.34896429025289 0.407407407407407 22.3 22 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.193016953767e-05 6.4796302488948e-05 1.34597323861153 0.40650406504065 22.3 22 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 6.60811390857539e-07 4.17926492973457e-06 1.3451320053374 0.40625 22.3 22 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.63843161605033e-05 8.73216550426824e-05 1.34085631555565 0.40495867768595 22.3 22 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 7.81912132865641e-06 4.32942009754011e-05 1.3396029835891 0.404580152671756 22.3 22 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 7.81912132865641e-06 4.32942009754011e-05 1.3396029835891 0.404580152671756 22.3 22 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.88006016786552e-23 6.52688374591509e-21 1.33885611728761 0.404354587869362 22.3 22 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.84357324345129e-17 1.95335883051114e-15 1.32578364003236 0.400406504065041 22.3 22 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000129243979498937 0.000583854548657102 1.32443766679375 0.4 22.3 22 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00124951236530797 0.00436868819615047 1.32443766679375 0.4 22.3 22 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00589265597137153 0.0158212253721919 1.32443766679375 0.4 22.3 22 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0130691917957955 0.0303384338098156 1.32443766679375 0.4 22.3 22 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0196245752060134 0.0442237700134673 1.32443766679375 0.4 22.3 22 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0196245752060134 0.0442237700134673 1.32443766679375 0.4 22.3 22 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0453843832314316 0.089572784103089 1.32443766679375 0.4 22.3 22 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0453843832314316 0.089572784103089 1.32443766679375 0.4 22.3 22 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0453843832314316 0.089572784103089 1.32443766679375 0.4 22.3 22 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0703694462270452 0.130725485614994 1.32443766679375 0.4 22.3 22 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0703694462270452 0.130725485614994 1.32443766679375 0.4 22.3 22 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0296926100755691 0.0620449106278044 1.32443766679375 0.4 22.3 22 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.111519472581882 0.192354193313961 1.32443766679375 0.4 22.3 22 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.111519472581882 0.192354193313961 1.32443766679375 0.4 22.3 22 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.111519472581882 0.192354193313961 1.32443766679375 0.4 22.3 22 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.8180977847973e-06 1.65026878508912e-05 1.3159476817502 0.397435897435897 22.3 22 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0121795791234694 0.0288465913044163 1.30903722880777 0.395348837209302 22.3 22 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0182423107608227 0.0414016079946582 1.30701085538857 0.394736842105263 22.3 22 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00236708526677751 0.00743370650604309 1.30437042941808 0.393939393939394 22.3 22 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000482508328173722 0.00194506898297792 1.30211568364554 0.393258426966292 22.3 22 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0418514503416873 0.0829451446186923 1.30078699417243 0.392857142857143 22.3 22 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0418514503416873 0.0829451446186923 1.30078699417243 0.392857142857143 22.3 22 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.53976342378237e-47 5.4777083801058e-45 1.29964186799645 0.392511297611362 22.3 22 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.0113211724185738 0.0276804610852757 1.29564554360258 0.391304347826087 22.3 22 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0644504392348172 0.120200491521815 1.29564554360258 0.391304347826087 22.3 22 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0254135347010873 0.0545451883554257 1.28764773160503 0.388888888888889 22.3 22 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.101023103512865 0.175312044266837 1.28764773160503 0.388888888888889 22.3 22 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.101023103512865 0.175312044266837 1.28764773160503 0.388888888888889 22.3 22 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000836804999199646 0.00306111443151953 1.27928638269851 0.386363636363636 22.3 22 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0156443726095256 0.0360809436359075 1.27928638269851 0.386363636363636 22.3 22 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.000342818485601787 0.00142224695338584 1.27349775653245 0.384615384615385 22.3 22 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0588805003426093 0.110829301570811 1.27349775653245 0.384615384615385 22.3 22 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.162898256280811 0.26222196684117 1.27349775653245 0.384615384615385 22.3 22 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.162898256280811 0.26222196684117 1.27349775653245 0.384615384615385 22.3 22 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.01099668232381e-05 0.000152478586439387 1.27349775653245 0.384615384615385 22.3 22 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.00178524364082336 0.00593551799273747 1.27349775653245 0.384615384615385 22.3 22 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0234291142538794 0.0518501237686943 1.27349775653245 0.384615384615385 22.3 22 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0234291142538794 0.0518501237686943 1.27349775653245 0.384615384615385 22.3 22 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00113611470809944 0.00402161997419278 1.27053613384284 0.383720930232558 22.3 22 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00165864937369853 0.00561966204469764 1.26720887872241 0.382716049382716 22.3 22 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00165864937369853 0.00561966204469764 1.26720887872241 0.382716049382716 22.3 22 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0089927903274284 0.0228922014954036 1.26423595466676 0.381818181818182 22.3 22 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0913853842533331 0.159169402438792 1.26136920647024 0.380952380952381 22.3 22 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0913853842533331 0.159169402438792 1.26136920647024 0.380952380952381 22.3 22 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0913853842533331 0.159169402438792 1.26136920647024 0.380952380952381 22.3 22 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 1.96825898949069e-05 0.000102594598609716 1.25451393904377 0.37888198757764 22.3 22 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 2.44843940409188e-05 0.000126236567826911 1.24677002583979 0.376543209876543 22.3 22 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.90928533889107e-15 1.46392448348473e-13 1.24673423100112 0.376532399299475 22.3 22 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00192714759740219 0.00628975007133788 1.24652956874706 0.376470588235294 22.3 22 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00192714759740219 0.00628975007133788 1.24652956874706 0.376470588235294 22.3 22 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00192714759740219 0.00628975007133788 1.24652956874706 0.376470588235294 22.3 22 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00192714759740219 0.00628975007133788 1.24652956874706 0.376470588235294 22.3 22 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00192714759740219 0.00628975007133788 1.24652956874706 0.376470588235294 22.3 22 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000499553600118212 0.00200809257900626 1.24545743895742 0.376146788990826 22.3 22 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0489543217010766 0.0962182317412045 1.24166031261914 0.375 22.3 22 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.144925801990664 0.235421708028213 1.24166031261914 0.375 22.3 22 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.144925801990664 0.235421708028213 1.24166031261914 0.375 22.3 22 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.144925801990664 0.235421708028213 1.24166031261914 0.375 22.3 22 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.144925801990664 0.235421708028213 1.24166031261914 0.375 22.3 22 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.144925801990664 0.235421708028213 1.24166031261914 0.375 22.3 22 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.144925801990664 0.235421708028213 1.24166031261914 0.375 22.3 22 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0826366884895946 0.150373411407536 1.24166031261914 0.375 22.3 22 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000619874420661957 0.00236271085483974 1.23413509860326 0.372727272727273 22.3 22 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.027128091551977 0.0574453486286656 1.2320350388779 0.372093023255814 22.3 22 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00956003635608425 0.0236590117125355 1.22830912646194 0.370967741935484 22.3 22 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0747361299128195 0.13829585548237 1.22633117295717 0.37037037037037 22.3 22 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0747361299128195 0.13829585548237 1.22633117295717 0.37037037037037 22.3 22 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00129812687950513 0.00451646589128556 1.22510484178422 0.37 22.3 22 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00203911155467459 0.00661559256781021 1.22366523562466 0.369565217391304 22.3 22 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0248134836665932 0.0535805572952383 1.22366523562466 0.369565217391304 22.3 22 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0248134836665932 0.0535805572952383 1.22366523562466 0.369565217391304 22.3 22 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0406178706800744 0.0820525102823162 1.21987679836266 0.368421052631579 22.3 22 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 9.48777829331136e-05 0.000442659295455149 1.21762817753619 0.367741935483871 22.3 22 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00807088845346552 0.020805931647249 1.21731403197955 0.367647058823529 22.3 22 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0226893320940091 0.0504483118277733 1.21632030623916 0.36734693877551 22.3 22 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0676176677413109 0.125942331408227 1.2140678612276 0.366666666666667 22.3 22 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00429758570544443 0.0122309289176948 1.21137591475038 0.365853658536585 22.3 22 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.0369914562647468 0.0760676911340096 1.21137591475038 0.365853658536585 22.3 22 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.59501444357645e-05 8.53272764364396e-05 1.21014609148667 0.365482233502538 22.3 22 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00395092629689023 0.0113579153948986 1.20757551972371 0.364705882352941 22.3 22 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00395092629689023 0.0113579153948986 1.20757551972371 0.364705882352941 22.3 22 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0612090155620873 0.114605827822171 1.20403424253977 0.363636363636364 22.3 22 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0612090155620873 0.114605827822171 1.20403424253977 0.363636363636364 22.3 22 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0612090155620873 0.114605827822171 1.20403424253977 0.363636363636364 22.3 22 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0612090155620873 0.114605827822171 1.20403424253977 0.363636363636364 22.3 22 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.000186367642725623 0.000818522085180745 1.19626627968468 0.361290322580645 22.3 22 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.103591110197311 0.179331082494858 1.19199390011437 0.36 22.3 22 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0502435742787434 0.0984801738273441 1.18859790609695 0.358974358974359 22.3 22 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.0455612350955635 0.0896730809695531 1.18253363106585 0.357142857142857 22.3 22 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0455612350955635 0.0896730809695531 1.18253363106585 0.357142857142857 22.3 22 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.207549925610229 0.321724993620213 1.18253363106585 0.357142857142857 22.3 22 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.207549925610229 0.321724993620213 1.18253363106585 0.357142857142857 22.3 22 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.207549925610229 0.321724993620213 1.18253363106585 0.357142857142857 22.3 22 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.207549925610229 0.321724993620213 1.18253363106585 0.357142857142857 22.3 22 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.207549925610229 0.321724993620213 1.18253363106585 0.357142857142857 22.3 22 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0413387804880687 0.0821579394336896 1.17727792603889 0.355555555555556 22.3 22 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00491867887185664 0.0134601539127923 1.17490438183316 0.354838709677419 22.3 22 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00924761543692887 0.0230354982051198 1.1735523629818 0.354430379746835 22.3 22 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0375281696258785 0.0768382523419066 1.1726791841403 0.354166666666667 22.3 22 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0375281696258785 0.0768382523419066 1.1726791841403 0.354166666666667 22.3 22 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.1822489480201 0.291202552612103 1.16862147070037 0.352941176470588 22.3 22 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.1822489480201 0.291202552612103 1.16862147070037 0.352941176470588 22.3 22 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.1822489480201 0.291202552612103 1.16862147070037 0.352941176470588 22.3 22 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00707450689747414 0.0186081761831898 1.1664081724604 0.352272727272727 22.3 22 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00039302457282826 0.00162108396270902 1.16617153051022 0.352201257861635 22.3 22 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00039302457282826 0.00162108396270902 1.16617153051022 0.352201257861635 22.3 22 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0613350778056737 0.114690953636628 1.15888295844453 0.35 22.3 22 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.160998340000037 0.260341633886423 1.15888295844453 0.35 22.3 22 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.160998340000037 0.260341633886423 1.15888295844453 0.35 22.3 22 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.142879651292596 0.234237032015397 1.15168492764674 0.347826086956522 22.3 22 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.142879651292596 0.234237032015397 1.15168492764674 0.347826086956522 22.3 22 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.127261433061565 0.21739858252894 1.1461479808792 0.346153846153846 22.3 22 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00172278817397274 0.00575475955766013 1.14427519006077 0.345588235294118 22.3 22 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.037317250787023 0.0766269089032232 1.14383253041278 0.345454545454545 22.3 22 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0338631792298635 0.0703464292614537 1.14175660930495 0.344827586206897 22.3 22 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0338631792298635 0.0703464292614537 1.14175660930495 0.344827586206897 22.3 22 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0338631792298635 0.0703464292614537 1.14175660930495 0.344827586206897 22.3 22 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0101272995614952 0.0250193529097355 1.14048799085017 0.344444444444444 22.3 22 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 7.17214390410162e-05 0.00034363504294736 1.13685636634656 0.343347639484979 22.3 22 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0020409312278768 0.00661559256781021 1.1359228164107 0.343065693430657 22.3 22 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00643332371897945 0.0171114386020706 1.13523228582321 0.342857142857143 22.3 22 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0230924881804028 0.0512646032460424 1.13523228582321 0.342857142857143 22.3 22 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0492138432616749 0.0965948951191219 1.12452254727771 0.339622641509434 22.3 22 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0025925301929173 0.00796797076570479 1.11924309869894 0.338028169014085 22.3 22 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00139714415412029 0.00483731418810992 1.11724036309289 0.337423312883436 22.3 22 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00363063650951702 0.0105652264888399 1.11175424584877 0.335766423357664 22.3 22 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0033206399228149 0.0098034659961942 1.1115816132019 0.335714285714286 22.3 22 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.079356641859074 0.145709034019951 1.10369805566146 0.333333333333333 22.3 22 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.122109760022042 0.209777107604287 1.10369805566146 0.333333333333333 22.3 22 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.153524084635938 0.249104643599703 1.10369805566146 0.333333333333333 22.3 22 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.195804817873389 0.309933543752872 1.10369805566146 0.333333333333333 22.3 22 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.222861870273718 0.342475638660368 1.10369805566146 0.333333333333333 22.3 22 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.222861870273718 0.342475638660368 1.10369805566146 0.333333333333333 22.3 22 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.222861870273718 0.342475638660368 1.10369805566146 0.333333333333333 22.3 22 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.07153415389902 0.132715907429342 1.10369805566146 0.333333333333333 22.3 22 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.0028906120826436 0.0087228516534954 1.09666813174005 0.331210191082803 22.3 22 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0560532842592329 0.107643486505922 1.08560464491291 0.327868852459016 22.3 22 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.161996686720286 0.261362001363909 1.0680948925756 0.32258064516129 22.3 22 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.161996686720286 0.261362001363909 1.0680948925756 0.32258064516129 22.3 22 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.182190831722906 0.291202552612103 1.06428026795926 0.321428571428571 22.3 22 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.205664672692585 0.321724993620213 1.059550133435 0.32 22.3 22 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.205664672692585 0.321724993620213 1.059550133435 0.32 22.3 22 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.205664672692585 0.321724993620213 1.059550133435 0.32 22.3 22 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.205664672692585 0.321724993620213 1.059550133435 0.32 22.3 22 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.061965906368978 0.115718483941018 1.05571118367618 0.318840579710145 22.3 22 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.266054320932593 0.395193422429102 1.04560868431085 0.315789473684211 22.3 22 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.266054320932593 0.395193422429102 1.04560868431085 0.315789473684211 22.3 22 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.266054320932593 0.395193422429102 1.04560868431085 0.315789473684211 22.3 22 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.102433473248123 0.17754303584906 1.0423814970136 0.314814814814815 22.3 22 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.168829103367407 0.271461936826915 1.04062959533794 0.314285714285714 22.3 22 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.189354493470996 0.300057287538116 1.03471692718262 0.3125 22.3 22 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.305855765821556 0.447770323831352 1.03471692718262 0.3125 22.3 22 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.130354031828558 0.222414613059998 1.01879820522596 0.307692307692308 22.3 22 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.174393328809606 0.28009221997299 1.01879820522596 0.307692307692308 22.3 22 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.144677242600541 0.235421708028213 1.0136002551993 0.306122448979592 22.3 22 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.16078748683808 0.260341633886423 1.00772431169089 0.304347826086957 22.3 22 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.218591334100977 0.337370356210077 1.00336186878314 0.303030303030303 22.3 22 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.218591334100977 0.337370356210077 1.00336186878314 0.303030303030303 22.3 22 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.218591334100977 0.337370356210077 1.00336186878314 0.303030303030303 22.3 22 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0950507730552034 0.165351161439553 1.0020416557979 0.302631578947368 22.3 22 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.245716785105085 0.366130874559724 0.993328250095311 0.3 22.3 22 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.22285547294795 0.342475638660368 0.984379346941299 0.297297297297297 22.3 22 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.277136440062343 0.407402018810655 0.981064938365739 0.296296296296296 22.3 22 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.357358606572162 0.502988424482875 0.973851225583638 0.294117647058824 22.3 22 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.357358606572162 0.502988424482875 0.973851225583638 0.294117647058824 22.3 22 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.357358606572162 0.502988424482875 0.973851225583638 0.294117647058824 22.3 22 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.357358606572162 0.502988424482875 0.973851225583638 0.294117647058824 22.3 22 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.357358606572162 0.502988424482875 0.973851225583638 0.294117647058824 22.3 22 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.357358606572162 0.502988424482875 0.973851225583638 0.294117647058824 22.3 22 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.000938471021310473 0.00338087155272102 0.969916473157037 0.292929292929293 22.3 22 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.206006335452399 0.321724993620213 0.965735798703774 0.291666666666667 22.3 22 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.313842395216194 0.458048952197583 0.965735798703774 0.291666666666667 22.3 22 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.313842395216194 0.458048952197583 0.965735798703774 0.291666666666667 22.3 22 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.188398096498586 0.298874572260298 0.963227394031816 0.290909090909091 22.3 22 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0253553075573459 0.0545024209276483 0.947881859568074 0.286274509803922 22.3 22 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.231955738955608 0.347451175693034 0.937102122731425 0.283018867924528 22.3 22 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.355911509530931 0.502988424482875 0.927106366755623 0.28 22.3 22 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.196477876561057 0.310653353718205 0.922076856628558 0.278481012658228 22.3 22 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.315078344085879 0.459381643067833 0.91974837971788 0.277777777777778 22.3 22 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.144535826864956 0.235421708028213 0.912506266491755 0.275590551181102 22.3 22 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.117033933684215 0.201621413598835 0.904775731675961 0.273255813953488 22.3 22 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.403670439341776 0.561693723259722 0.903025681904828 0.272727272727273 22.3 22 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.311789652634148 0.455988361457752 0.896754670224933 0.270833333333333 22.3 22 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.182334135191415 0.291202552612103 0.895623832053149 0.270491803278689 22.3 22 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.398427649946996 0.559134660625814 0.891448429572715 0.269230769230769 22.3 22 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.393387571449001 0.552606628007826 0.882958444529165 0.266666666666667 22.3 22 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.275610950595147 0.407402018810655 0.880164272236351 0.265822784810127 22.3 22 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.460171620390428 0.616015254765361 0.871340570259044 0.263157894736842 22.3 22 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.316816028857496 0.460970561415355 0.856989078513601 0.258823529411765 22.3 22 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.316816028857496 0.460970561415355 0.856989078513601 0.258823529411765 22.3 22 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.432838581948652 0.579971094268298 0.854475914060482 0.258064516129032 22.3 22 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.432838581948652 0.579971094268298 0.854475914060482 0.258064516129032 22.3 22 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00512450655054542 0.0139696797345328 0.846347972438931 0.255609756097561 22.3 22 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.21139522342955 0.327329056518226 0.84400439550582 0.254901960784314 22.3 22 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.471977255943694 0.631225221060034 0.827773541746092 0.25 22.3 22 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.488158956872307 0.645585683670347 0.807583943166919 0.24390243902439 22.3 22 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.385370853224277 0.541880162191844 0.805401283861063 0.243243243243243 22.3 22 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.523780637874546 0.685055007073051 0.799229626513468 0.241379310344828 22.3 22 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.501017670910127 0.661975994155164 0.794662600076249 0.24 22.3 22 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.539207280097409 0.703723562724871 0.794662600076249 0.24 22.3 22 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.570109180965218 0.730211849247079 0.757961315333771 0.228915662650602 22.3 22 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.578993901963744 0.740924750444611 0.755161827557839 0.228070175438596 22.3 22 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.59115903792348 0.752432299611013 0.74968169818514 0.226415094339623 22.3 22 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.601564997328192 0.764992842893671 0.747666424802922 0.225806451612903 22.3 22 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.62101121963322 0.785510191589397 0.735798703774304 0.222222222222222 22.3 22 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.621601625067078 0.785558714449779 0.735798703774304 0.222222222222222 22.3 22 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.640425809042849 0.798476265009105 0.732261210006159 0.221153846153846 22.3 22 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.676604045172323 0.822912441265142 0.726825548850227 0.219512195121951 22.3 22 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.652276557023328 0.798476265009105 0.715912252320945 0.216216216216216 22.3 22 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.659456285519155 0.804118504107762 0.709520178639508 0.214285714285714 22.3 22 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.677215319110868 0.822952518441302 0.704488120634972 0.212765957446809 22.3 22 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.708305166977752 0.856814211421196 0.704488120634972 0.212765957446809 22.3 22 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.716736852216816 0.860689063885678 0.7023533081482 0.212121212121212 22.3 22 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.684851899094423 0.8315223996684 0.68981128478841 0.208333333333333 22.3 22 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.694849932730792 0.842942416262504 0.685053965582973 0.206896551724138 22.3 22 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.727696044868996 0.873112539501334 0.662218833396874 0.2 22.3 22 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.910722375885559 1 0.640856935545362 0.193548387096774 22.3 22 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.866544744155905 1 0.627365210586512 0.189473684210526 22.3 22 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.888049953269789 1 0.61442984541978 0.185567010309278 22.3 22 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.784770422796485 0.92591581571116 0.613165586478587 0.185185185185185 22.3 22 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.832800797955352 0.968198966903976 0.594298953048476 0.179487179487179 22.3 22 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.812012626552426 0.944802917076126 0.591266815532923 0.178571428571429 22.3 22 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.833755180247192 0.968517242034085 0.584310735350183 0.176470588235294 22.3 22 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.854317780469008 0.987566370111616 0.567616142911606 0.171428571428571 22.3 22 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.897116675888125 1 0.551849027830728 0.166666666666667 22.3 22 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.92585657999411 1 0.542802322456454 0.163934426229508 22.3 22 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.877435677895623 1 0.534047446287801 0.161290322580645 22.3 22 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.877435677895623 1 0.534047446287801 0.161290322580645 22.3 22 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.958903069735367 1 0.512986420237015 0.154929577464789 22.3 22 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.954332318413106 1 0.462013139579214 0.13953488372093 22.3 22 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999998449462225 1 0.460822384064835 0.139175257731959 22.3 22 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.997437002672688 1 0.429215910535011 0.12962962962963 22.3 22 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.979534035910482 1 0.413886770873046 0.125 22.3 22 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.99719559306467 1 0.404689287075867 0.122222222222222 22.3 22 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999168605672 1 0.402061434562388 0.121428571428571 22.3 22 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.386433324274414 0.116708648194794 22.3 22 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999980792920762 1 0.376260700793678 0.113636363636364 22.3 22 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999998586821495 1 0.366203963168778 0.110599078341014 22.3 22 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.302369358829495 0.0913200723327306 22.3 22 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 5.28284321053741e-07 3.70319501901218e-06 2.33372641509434 1 23.1 23 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 6.54219591796084e-05 0.000285568858627554 2.33372641509434 1 23.1 23 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 6.54219591796084e-05 0.000285568858627554 2.33372641509434 1 23.1 23 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 6.54219591796084e-05 0.000285568858627554 2.33372641509434 1 23.1 23 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.000218204011160859 0.000834688999682534 2.33372641509434 1 23.1 23 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.000218204011160859 0.000834688999682534 2.33372641509434 1 23.1 23 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.000727732905659196 0.00235355437443872 2.33372641509434 1 23.1 23 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.000727732905659196 0.00235355437443872 2.33372641509434 1 23.1 23 1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.000727732905659196 0.00235355437443872 2.33372641509434 1 23.1 23 1 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00242689729889433 0.00674506807876295 2.33372641509434 1 23.1 23 1 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.00242689729889433 0.00674506807876295 2.33372641509434 1 23.1 23 1 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00242689729889433 0.00674506807876295 2.33372641509434 1 23.1 23 1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00242689729889433 0.00674506807876295 2.33372641509434 1 23.1 23 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00242689729889433 0.00674506807876295 2.33372641509434 1 23.1 23 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00242689729889433 0.00674506807876295 2.33372641509434 1 23.1 23 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00242689729889433 0.00674506807876295 2.33372641509434 1 23.1 23 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 1.53387469552505e-05 7.57883226295886e-05 2.13924921383648 0.916666666666667 23.1 23 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 1.53387469552505e-05 7.57883226295886e-05 2.13924921383648 0.916666666666667 23.1 23 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 1.53387469552505e-05 7.57883226295886e-05 2.13924921383648 0.916666666666667 23.1 23 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 1.53387469552505e-05 7.57883226295886e-05 2.13924921383648 0.916666666666667 23.1 23 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 1.53387469552505e-05 7.57883226295886e-05 2.13924921383648 0.916666666666667 23.1 23 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 4.05272445305926e-09 4.02388002965411e-08 2.12156946826758 0.909090909090909 23.1 23 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 4.70518479611935e-05 0.000211569423311379 2.12156946826758 0.909090909090909 23.1 23 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 4.70518479611935e-05 0.000211569423311379 2.12156946826758 0.909090909090909 23.1 23 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.2322822990065e-08 1.10983399461155e-07 2.11146675651393 0.904761904761905 23.1 23 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.000143217374076392 0.000561427887908279 2.10035377358491 0.9 23.1 23 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.66926960430306e-13 6.43791635071738e-12 2.07442348008386 0.888888888888889 23.1 23 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000431889864969758 0.00153644819462991 2.07442348008386 0.888888888888889 23.1 23 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.000431889864969758 0.00153644819462991 2.07442348008386 0.888888888888889 23.1 23 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000431889864969758 0.00153644819462991 2.07442348008386 0.888888888888889 23.1 23 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.00058142286659e-06 6.6846355152073e-06 2.05917036625971 0.882352941176471 23.1 23 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.5760352363886e-09 2.68247147908792e-08 2.05367924528302 0.88 23.1 23 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00128767837502961 0.00394906536135159 2.04201061320755 0.875 23.1 23 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00128767837502961 0.00394906536135159 2.04201061320755 0.875 23.1 23 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00128767837502961 0.00394906536135159 2.04201061320755 0.875 23.1 23 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 2.51747730555655e-05 0.000120213765295536 2.00033692722372 0.857142857142857 23.1 23 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 2.51747730555655e-05 0.000120213765295536 2.00033692722372 0.857142857142857 23.1 23 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 2.51747730555655e-05 0.000120213765295536 2.00033692722372 0.857142857142857 23.1 23 1 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.00378490627264921 0.00986432532230738 2.00033692722372 0.857142857142857 23.1 23 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00378490627264921 0.00986432532230738 2.00033692722372 0.857142857142857 23.1 23 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00378490627264921 0.00986432532230738 2.00033692722372 0.857142857142857 23.1 23 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00378490627264921 0.00986432532230738 2.00033692722372 0.857142857142857 23.1 23 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00378490627264921 0.00986432532230738 2.00033692722372 0.857142857142857 23.1 23 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00378490627264921 0.00986432532230738 2.00033692722372 0.857142857142857 23.1 23 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00378490627264921 0.00986432532230738 2.00033692722372 0.857142857142857 23.1 23 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.87135511291633e-07 1.37976079050774e-06 2.00033692722372 0.857142857142857 23.1 23 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 5.3736069799905e-07 3.74835428065023e-06 1.98366745283019 0.85 23.1 23 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 7.23796855303418e-05 0.000311167046857028 1.9746915820029 0.846153846153846 23.1 23 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 7.23796855303418e-05 0.000311167046857028 1.9746915820029 0.846153846153846 23.1 23 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 7.23796855303418e-05 0.000311167046857028 1.9746915820029 0.846153846153846 23.1 23 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 7.23796855303418e-05 0.000311167046857028 1.9746915820029 0.846153846153846 23.1 23 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 9.54004802065182e-08 7.3381018018311e-07 1.94477201257862 0.833333333333333 23.1 23 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 4.32212801967904e-06 2.55202828713829e-05 1.94477201257862 0.833333333333333 23.1 23 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 4.32212801967904e-06 2.55202828713829e-05 1.94477201257862 0.833333333333333 23.1 23 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.01092271926507 0.0244387256512494 1.94477201257862 0.833333333333333 23.1 23 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.01092271926507 0.0244387256512494 1.94477201257862 0.833333333333333 23.1 23 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.01092271926507 0.0244387256512494 1.94477201257862 0.833333333333333 23.1 23 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.01092271926507 0.0244387256512494 1.94477201257862 0.833333333333333 23.1 23 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 3.86887840639121e-10 4.74719535328547e-09 1.9218923418424 0.823529411764706 23.1 23 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 1.20834076832602e-05 6.22995983089831e-05 1.9218923418424 0.823529411764706 23.1 23 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 1.20834076832602e-05 6.22995983089831e-05 1.9218923418424 0.823529411764706 23.1 23 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.000575962241594782 0.00196075184160138 1.90941252144082 0.818181818181818 23.1 23 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.000575962241594782 0.00196075184160138 1.90941252144082 0.818181818181818 23.1 23 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000575962241594782 0.00196075184160138 1.90941252144082 0.818181818181818 23.1 23 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.000575962241594782 0.00196075184160138 1.90941252144082 0.818181818181818 23.1 23 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.000575962241594782 0.00196075184160138 1.90941252144082 0.818181818181818 23.1 23 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.000575962241594782 0.00196075184160138 1.90941252144082 0.818181818181818 23.1 23 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.000575962241594782 0.00196075184160138 1.90941252144082 0.818181818181818 23.1 23 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.000575962241594782 0.00196075184160138 1.90941252144082 0.818181818181818 23.1 23 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 3.34079582950102e-05 0.000156896120969635 1.89615271226415 0.8125 23.1 23 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 3.34079582950102e-05 0.000156896120969635 1.89615271226415 0.8125 23.1 23 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 3.34079582950102e-05 0.000156896120969635 1.89615271226415 0.8125 23.1 23 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00158657982854322 0.00465505792993197 1.86698113207547 0.8 23.1 23 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.00158657982854322 0.00465505792993197 1.86698113207547 0.8 23.1 23 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00158657982854322 0.00465505792993197 1.86698113207547 0.8 23.1 23 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 9.12096801064393e-05 0.00038173933762195 1.86698113207547 0.8 23.1 23 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 9.12096801064393e-05 0.00038173933762195 1.86698113207547 0.8 23.1 23 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 9.12096801064393e-05 0.00038173933762195 1.86698113207547 0.8 23.1 23 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 1.47897608202424e-05 7.44671127704175e-05 1.84241559086395 0.789473684210526 23.1 23 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 1.47897608202424e-05 7.44671127704175e-05 1.84241559086395 0.789473684210526 23.1 23 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000245464364604522 0.000923217796654221 1.83364218328841 0.785714285714286 23.1 23 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000245464364604522 0.000923217796654221 1.83364218328841 0.785714285714286 23.1 23 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 1.67821379573552e-09 1.82297574910812e-08 1.82913691993881 0.783783783783784 23.1 23 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 2.43595039531613e-06 1.51084801931544e-05 1.826394585726 0.782608695652174 23.1 23 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.59859280599959e-08 2.17517503702201e-07 1.82322376179245 0.78125 23.1 23 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 3.92478865057945e-05 0.000181920985334676 1.81512054507338 0.777777777777778 23.1 23 1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.00428293816023911 0.0107488906561204 1.81512054507338 0.777777777777778 23.1 23 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00428293816023911 0.0107488906561204 1.81512054507338 0.777777777777778 23.1 23 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00428293816023911 0.0107488906561204 1.81512054507338 0.777777777777778 23.1 23 1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.00428293816023911 0.0107488906561204 1.81512054507338 0.777777777777778 23.1 23 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00428293816023911 0.0107488906561204 1.81512054507338 0.777777777777778 23.1 23 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00428293816023911 0.0107488906561204 1.81512054507338 0.777777777777778 23.1 23 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00428293816023911 0.0107488906561204 1.81512054507338 0.777777777777778 23.1 23 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 6.40407574145478e-06 3.40037305227244e-05 1.80333404802744 0.772727272727273 23.1 23 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.0594036610901e-06 6.97931208208897e-06 1.79517416545718 0.769230769230769 23.1 23 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.0594036610901e-06 6.97931208208897e-06 1.79517416545718 0.769230769230769 23.1 23 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.000649742911192796 0.00214164739508288 1.79517416545718 0.769230769230769 23.1 23 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.000649742911192796 0.00214164739508288 1.79517416545718 0.769230769230769 23.1 23 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.000649742911192796 0.00214164739508288 1.79517416545718 0.769230769230769 23.1 23 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000649742911192796 0.00214164739508288 1.79517416545718 0.769230769230769 23.1 23 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 6.52264015231032e-13 1.34517636764313e-11 1.79196849730458 0.767857142857143 23.1 23 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.76993331887417e-07 1.31177870456143e-06 1.78919025157233 0.766666666666667 23.1 23 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.76993331887417e-07 1.31177870456143e-06 1.78919025157233 0.766666666666667 23.1 23 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 1.76993331887417e-07 1.31177870456143e-06 1.78919025157233 0.766666666666667 23.1 23 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 1.6635668230903e-05 8.10703968923801e-05 1.77807726864331 0.761904761904762 23.1 23 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 2.7376839252805e-06 1.67919147658369e-05 1.7736320754717 0.76 23.1 23 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.7376839252805e-06 1.67919147658369e-05 1.7736320754717 0.76 23.1 23 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 4.26459825640266e-05 0.000194503952527596 1.75029481132075 0.75 23.1 23 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 4.26459825640266e-05 0.000194503952527596 1.75029481132075 0.75 23.1 23 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000264614845540727 0.000972989470812544 1.75029481132075 0.75 23.1 23 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000264614845540727 0.000972989470812544 1.75029481132075 0.75 23.1 23 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000264614845540727 0.000972989470812544 1.75029481132075 0.75 23.1 23 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000264614845540727 0.000972989470812544 1.75029481132075 0.75 23.1 23 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00168699690740641 0.00487926138056773 1.75029481132075 0.75 23.1 23 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.00168699690740641 0.00487926138056773 1.75029481132075 0.75 23.1 23 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.011276589965508 0.024878430264989 1.75029481132075 0.75 23.1 23 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.011276589965508 0.024878430264989 1.75029481132075 0.75 23.1 23 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.011276589965508 0.024878430264989 1.75029481132075 0.75 23.1 23 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.011276589965508 0.024878430264989 1.75029481132075 0.75 23.1 23 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.011276589965508 0.024878430264989 1.75029481132075 0.75 23.1 23 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.011276589965508 0.024878430264989 1.75029481132075 0.75 23.1 23 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.92720710810311e-06 1.77902744309379e-05 1.72868623340321 0.740740740740741 23.1 23 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 5.95260388222344e-09 5.57273376605523e-08 1.7225123539982 0.738095238095238 23.1 23 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.49525189314978e-08 2.85847324365066e-07 1.71958788480636 0.736842105263158 23.1 23 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00010773063842534 0.000434279599091383 1.71958788480636 0.736842105263158 23.1 23 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000669664746974246 0.00219065042515943 1.71139937106918 0.733333333333333 23.1 23 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 7.29301607094012e-06 3.81542715770139e-05 1.70541545718433 0.730769230769231 23.1 23 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 7.29301607094012e-06 3.81542715770139e-05 1.70541545718433 0.730769230769231 23.1 23 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 7.29301607094012e-06 3.81542715770139e-05 1.70541545718433 0.730769230769231 23.1 23 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 7.29301607094012e-06 3.81542715770139e-05 1.70541545718433 0.730769230769231 23.1 23 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 1.0675272972714e-09 1.19613491654898e-08 1.70167551100629 0.729166666666667 23.1 23 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00428156006040572 0.0107488906561204 1.69725557461407 0.727272727272727 23.1 23 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00428156006040572 0.0107488906561204 1.69725557461407 0.727272727272727 23.1 23 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.00428156006040572 0.0107488906561204 1.69725557461407 0.727272727272727 23.1 23 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00428156006040572 0.0107488906561204 1.69725557461407 0.727272727272727 23.1 23 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.00428156006040572 0.0107488906561204 1.69725557461407 0.727272727272727 23.1 23 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00428156006040572 0.0107488906561204 1.69725557461407 0.727272727272727 23.1 23 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 3.62474909065837e-08 2.94743883200392e-07 1.6919516509434 0.725 23.1 23 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 3.01317537646278e-06 1.81684261046887e-05 1.68993981782694 0.724137931034483 23.1 23 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 2.12084107442828e-07 1.54767017892894e-06 1.68546907756813 0.722222222222222 23.1 23 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.12084107442828e-07 1.54767017892894e-06 1.68546907756813 0.722222222222222 23.1 23 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000267721387104446 0.000981274915097224 1.68546907756813 0.722222222222222 23.1 23 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 3.20219156374776e-14 9.11343719042612e-13 1.67549588776004 0.717948717948718 23.1 23 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 8.82860046510777e-08 6.82777090317845e-07 1.67549588776004 0.717948717948718 23.1 23 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 2.37452327777474e-15 8.66396570326527e-14 1.67479189789123 0.717647058823529 23.1 23 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 2.37452327777474e-15 8.66396570326527e-14 1.67479189789123 0.717647058823529 23.1 23 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 6.34750200871692e-09 5.88303101398184e-08 1.6741950369155 0.717391304347826 23.1 23 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 7.34232896313256e-06 3.82715535331049e-05 1.6669474393531 0.714285714285714 23.1 23 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.00166043927766348 0.00482205120839823 1.6669474393531 0.714285714285714 23.1 23 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00166043927766348 0.00482205120839823 1.6669474393531 0.714285714285714 23.1 23 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00166043927766348 0.00482205120839823 1.6669474393531 0.714285714285714 23.1 23 1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.028767251746122 0.0563853983949471 1.6669474393531 0.714285714285714 23.1 23 1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_225157.1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE 0.028767251746122 0.0563853983949471 1.6669474393531 0.714285714285714 23.1 23 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.028767251746122 0.0563853983949471 1.6669474393531 0.714285714285714 23.1 23 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.028767251746122 0.0563853983949471 1.6669474393531 0.714285714285714 23.1 23 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.028767251746122 0.0563853983949471 1.6669474393531 0.714285714285714 23.1 23 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.028767251746122 0.0563853983949471 1.6669474393531 0.714285714285714 23.1 23 1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_216831.1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE 0.028767251746122 0.0563853983949471 1.6669474393531 0.714285714285714 23.1 23 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.028767251746122 0.0563853983949471 1.6669474393531 0.714285714285714 23.1 23 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.65403668466465e-09 2.69763871591271e-08 1.6669474393531 0.714285714285714 23.1 23 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000107671768396835 0.000434279599091383 1.6669474393531 0.714285714285714 23.1 23 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.52945995396392e-08 1.32708628932357e-07 1.65953878406709 0.711111111111111 23.1 23 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 5.77344033858373e-15 1.95609657185825e-13 1.65531757349715 0.709302325581395 23.1 23 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 6.36673771014198e-09 5.88303101398184e-08 1.65305621069182 0.708333333333333 23.1 23 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.27032562025306e-14 9.12484972082373e-13 1.65068453750575 0.707317073170732 23.1 23 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.33766346974486e-20 7.61398046978774e-19 1.65068453750575 0.707317073170732 23.1 23 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.15552576386535e-23 2.36332271683178e-21 1.65027796495957 0.707142857142857 23.1 23 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 5.9638594466363e-12 1.16254410857034e-10 1.64733629300777 0.705882352941177 23.1 23 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.23685049767486e-06 8.11077538337014e-06 1.64733629300777 0.705882352941177 23.1 23 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000653179880158797 0.00214164739508288 1.64733629300777 0.705882352941177 23.1 23 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000653179880158797 0.00214164739508288 1.64733629300777 0.705882352941177 23.1 23 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000653179880158797 0.00214164739508288 1.64733629300777 0.705882352941177 23.1 23 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000653179880158797 0.00214164739508288 1.64733629300777 0.705882352941177 23.1 23 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000653179880158797 0.00214164739508288 1.64733629300777 0.705882352941177 23.1 23 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.65079022180341e-09 2.69763871591271e-08 1.64733629300777 0.705882352941177 23.1 23 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.65079022180341e-09 2.69763871591271e-08 1.64733629300777 0.705882352941177 23.1 23 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 7.49629635969793e-23 5.33361485992508e-21 1.64536106963486 0.705035971223022 23.1 23 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.6541626431931e-08 2.9544735461726e-07 1.64421633790738 0.704545454545455 23.1 23 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 7.45608696677174e-26 7.57857982408299e-24 1.6438827578023 0.70440251572327 23.1 23 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 1.76618123576781e-05 8.54855747788296e-05 1.64225192173305 0.703703703703704 23.1 23 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 5.08919645422403e-07 3.60294853450786e-06 1.63991585925548 0.702702702702703 23.1 23 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.32995831433832e-20 7.61398046978774e-19 1.63544607042044 0.700787401574803 23.1 23 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.16841104681494e-25 3.70728057476104e-23 1.63509494051196 0.700636942675159 23.1 23 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000259594835435071 0.000964499871603409 1.63360849056604 0.7 23.1 23 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000259594835435071 0.000964499871603409 1.63360849056604 0.7 23.1 23 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.000259594835435071 0.000964499871603409 1.63360849056604 0.7 23.1 23 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0105744409341962 0.0238469563381318 1.63360849056604 0.7 23.1 23 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 7.98408829222771e-11 1.04232638897615e-09 1.62990416292303 0.698412698412698 23.1 23 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 5.49026380893632e-24 4.34035855562021e-22 1.62746710526316 0.697368421052632 23.1 23 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 2.93795818079439e-06 1.77902744309379e-05 1.62653659233848 0.696969696969697 23.1 23 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.34530247638156e-14 4.16166396498034e-13 1.62574199703201 0.696629213483146 23.1 23 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.94952335352591e-32 5.24646466508422e-30 1.62249550763702 0.695238095238095 23.1 23 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 7.5268295956942e-14 1.87906640608296e-12 1.61988068812431 0.694117647058824 23.1 23 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 7.5268295956942e-14 1.87906640608296e-12 1.61988068812431 0.694117647058824 23.1 23 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 7.5268295956942e-14 1.87906640608296e-12 1.61988068812431 0.694117647058824 23.1 23 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 7.5268295956942e-14 1.87906640608296e-12 1.61988068812431 0.694117647058824 23.1 23 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 7.5268295956942e-14 1.87906640608296e-12 1.61988068812431 0.694117647058824 23.1 23 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.96313034940348e-28 5.12684953381923e-26 1.61958062686875 0.693989071038251 23.1 23 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 3.14604800999683e-14 9.11343719042612e-13 1.61769671955403 0.693181818181818 23.1 23 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.51858744811919e-22 6.44997616127314e-20 1.61693901617251 0.692857142857143 23.1 23 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 4.1894458926605e-05 0.000193557841079737 1.61565674891147 0.692307692307692 23.1 23 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00402081839888704 0.0103840736508462 1.61565674891147 0.692307692307692 23.1 23 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00402081839888704 0.0103840736508462 1.61565674891147 0.692307692307692 23.1 23 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00402081839888704 0.0103840736508462 1.61565674891147 0.692307692307692 23.1 23 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 7.78870218143759e-11 1.02623363001719e-09 1.61565674891147 0.692307692307692 23.1 23 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 4.2024660960775e-13 9.49223691225125e-12 1.61344048450967 0.691358024691358 23.1 23 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 4.99582011914741e-24 4.1817953114981e-22 1.60443691037736 0.6875 23.1 23 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 3.44730155235985e-08 2.83555497630524e-07 1.60443691037736 0.6875 23.1 23 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.00156077453012799 0.00460784679745255 1.60443691037736 0.6875 23.1 23 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.00156077453012799 0.00460784679745255 1.60443691037736 0.6875 23.1 23 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.00156077453012799 0.00460784679745255 1.60443691037736 0.6875 23.1 23 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.94855678399951e-14 8.74124229923188e-13 1.59809526251025 0.684782608695652 23.1 23 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00061436800924251 0.0020815373265526 1.59676017874876 0.684210526315789 23.1 23 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.96492932976985e-39 1.41052360906562e-36 1.59585703385128 0.683823529411765 23.1 23 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.00873691594156e-09 1.13923224713083e-08 1.59471305031447 0.683333333333333 23.1 23 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.00873691594156e-09 1.13923224713083e-08 1.59471305031447 0.683333333333333 23.1 23 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.00873691594156e-09 1.13923224713083e-08 1.59471305031447 0.683333333333333 23.1 23 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.00873691594156e-09 1.13923224713083e-08 1.59471305031447 0.683333333333333 23.1 23 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.00873691594156e-09 1.13923224713083e-08 1.59471305031447 0.683333333333333 23.1 23 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.00873691594156e-09 1.13923224713083e-08 1.59471305031447 0.683333333333333 23.1 23 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.00873691594156e-09 1.13923224713083e-08 1.59471305031447 0.683333333333333 23.1 23 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.90470976535724e-13 8.9619387033925e-12 1.59242508324084 0.682352941176471 23.1 23 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 7.20101052826974e-11 9.66701696389418e-10 1.58963973202078 0.681159420289855 23.1 23 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 7.96814466455328e-08 6.19599445773734e-07 1.58892011240466 0.680851063829787 23.1 23 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 9.787319911561e-05 0.000400211386038831 1.58693396226415 0.68 23.1 23 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.35517934903965e-08 1.21284290168769e-07 1.58517265930936 0.679245283018868 23.1 23 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.14990352916592e-12 4.30889115775085e-11 1.58462904728628 0.679012345679012 23.1 23 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.59751414037843e-05 7.83883662675347e-05 1.58091144248326 0.67741935483871 23.1 23 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 1.59751414037843e-05 7.83883662675347e-05 1.58091144248326 0.67741935483871 23.1 23 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 4.4418611235606e-07 3.16038418941337e-06 1.57390851250549 0.674418604651163 23.1 23 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.82010213739617e-18 1.94143047911241e-16 1.56180152394775 0.669230769230769 23.1 23 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 1.19271052642099e-08 1.08103635611278e-07 1.55581761006289 0.666666666666667 23.1 23 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 6.03013357479917e-06 3.22589476576662e-05 1.55581761006289 0.666666666666667 23.1 23 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 6.03013357479917e-06 3.22589476576662e-05 1.55581761006289 0.666666666666667 23.1 23 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 1.48096928419031e-05 7.44671127704175e-05 1.55581761006289 0.666666666666667 23.1 23 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 9.03597520644587e-05 0.000381548745364168 1.55581761006289 0.666666666666667 23.1 23 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 9.03597520644587e-05 0.000381548745364168 1.55581761006289 0.666666666666667 23.1 23 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000224879483888603 0.000857918245505315 1.55581761006289 0.666666666666667 23.1 23 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000563440969511541 0.00195555243808518 1.55581761006289 0.666666666666667 23.1 23 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0014240968662675 0.00431168051212478 1.55581761006289 0.666666666666667 23.1 23 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0014240968662675 0.00431168051212478 1.55581761006289 0.666666666666667 23.1 23 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0014240968662675 0.00431168051212478 1.55581761006289 0.666666666666667 23.1 23 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00364198833904194 0.00961511949249848 1.55581761006289 0.666666666666667 23.1 23 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00364198833904194 0.00961511949249848 1.55581761006289 0.666666666666667 23.1 23 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00364198833904194 0.00961511949249848 1.55581761006289 0.666666666666667 23.1 23 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00364198833904194 0.00961511949249848 1.55581761006289 0.666666666666667 23.1 23 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00947068636640435 0.0218070982190832 1.55581761006289 0.666666666666667 23.1 23 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00947068636640435 0.0218070982190832 1.55581761006289 0.666666666666667 23.1 23 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00947068636640435 0.0218070982190832 1.55581761006289 0.666666666666667 23.1 23 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00947068636640435 0.0218070982190832 1.55581761006289 0.666666666666667 23.1 23 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.00947068636640435 0.0218070982190832 1.55581761006289 0.666666666666667 23.1 23 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00947068636640435 0.0218070982190832 1.55581761006289 0.666666666666667 23.1 23 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0252638935760458 0.0515050437803914 1.55581761006289 0.666666666666667 23.1 23 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0252638935760458 0.0515050437803914 1.55581761006289 0.666666666666667 23.1 23 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0252638935760458 0.0515050437803914 1.55581761006289 0.666666666666667 23.1 23 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0252638935760458 0.0515050437803914 1.55581761006289 0.666666666666667 23.1 23 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.10121401412744e-14 6.36176072787945e-13 1.54833771770682 0.663461538461538 23.1 23 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.33069172509933e-11 4.32479886711269e-10 1.54609375 0.6625 23.1 23 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.46409292622727e-16 1.03129536294747e-14 1.54295961328551 0.661157024793388 23.1 23 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.46409292622727e-16 1.03129536294747e-14 1.54295961328551 0.661157024793388 23.1 23 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 8.13893726972964e-15 2.63220630336938e-13 1.54154405400727 0.660550458715596 23.1 23 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 6.47660737466092e-08 5.0638529088695e-07 1.54114008543966 0.660377358490566 23.1 23 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 9.2856919209237e-07 6.23280169975209e-06 1.538137864494 0.659090909090909 23.1 23 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 9.2856919209237e-07 6.23280169975209e-06 1.538137864494 0.659090909090909 23.1 23 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 9.2856919209237e-07 6.23280169975209e-06 1.538137864494 0.659090909090909 23.1 23 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.26390019070017e-06 1.41295174182734e-05 1.53684422457432 0.658536585365854 23.1 23 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.26390019070017e-06 1.41295174182734e-05 1.53684422457432 0.658536585365854 23.1 23 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 2.26390019070017e-06 1.41295174182734e-05 1.53684422457432 0.658536585365854 23.1 23 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 5.53198069524555e-06 3.00558548144036e-05 1.53534632571996 0.657894736842105 23.1 23 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.00524321698736e-10 3.78447884758674e-09 1.53450504006203 0.657534246575342 23.1 23 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.00524321698736e-10 3.78447884758674e-09 1.53450504006203 0.657534246575342 23.1 23 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.35534248539805e-05 6.88804413114796e-05 1.53359164420485 0.657142857142857 23.1 23 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.21001275295449e-09 4.13161941203741e-08 1.53150795990566 0.65625 23.1 23 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 3.33095691360597e-05 0.000156896120969635 1.53150795990566 0.65625 23.1 23 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 8.21683528902043e-05 0.00034903154078436 1.52899316851008 0.655172413793103 23.1 23 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00020361081947262 0.000783076205701454 1.52589804063861 0.653846153846154 23.1 23 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00020361081947262 0.000783076205701454 1.52589804063861 0.653846153846154 23.1 23 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000507365660039538 0.00177390991212841 1.521995488105 0.652173913043478 23.1 23 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.000507365660039538 0.00177390991212841 1.521995488105 0.652173913043478 23.1 23 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000507365660039538 0.00177390991212841 1.521995488105 0.652173913043478 23.1 23 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 9.28958127864369e-09 8.47376548686536e-08 1.51877433363282 0.650793650793651 23.1 23 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 4.98984330480889e-18 2.36684900758102e-16 1.51773815806835 0.65034965034965 23.1 23 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.87225610769227e-27 3.14401572403547e-25 1.51744542685506 0.650224215246637 23.1 23 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0012732324748849 0.00393017312746467 1.51692216981132 0.65 23.1 23 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0012732324748849 0.00393017312746467 1.51692216981132 0.65 23.1 23 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00322469805507152 0.00869080555372494 1.51005826859046 0.647058823529412 23.1 23 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00322469805507152 0.00869080555372494 1.51005826859046 0.647058823529412 23.1 23 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 7.67304134935451e-07 5.27475257977365e-06 1.50719830974843 0.645833333333333 23.1 23 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.03329941395806e-08 1.72225301551329e-07 1.50562994522215 0.645161290322581 23.1 23 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.86167500632792e-06 1.17740601511317e-05 1.5039570230608 0.644444444444444 23.1 23 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000182002006637391 0.000709558508068512 1.50025269541779 0.642857142857143 23.1 23 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000182002006637391 0.000709558508068512 1.50025269541779 0.642857142857143 23.1 23 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.00826950081708944 0.0193226595446934 1.50025269541779 0.642857142857143 23.1 23 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00826950081708944 0.0193226595446934 1.50025269541779 0.642857142857143 23.1 23 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00826950081708944 0.0193226595446934 1.50025269541779 0.642857142857143 23.1 23 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00826950081708944 0.0193226595446934 1.50025269541779 0.642857142857143 23.1 23 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00826950081708944 0.0193226595446934 1.50025269541779 0.642857142857143 23.1 23 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00826950081708944 0.0193226595446934 1.50025269541779 0.642857142857143 23.1 23 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00826950081708944 0.0193226595446934 1.50025269541779 0.642857142857143 23.1 23 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00826950081708944 0.0193226595446934 1.50025269541779 0.642857142857143 23.1 23 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 7.62914873001073e-09 7.00405073729372e-08 1.49776471416502 0.641791044776119 23.1 23 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 1.83444643026984e-08 1.57254052426143e-07 1.49504348466981 0.640625 23.1 23 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00045066843459615 0.0015913180705467 1.49358490566038 0.64 23.1 23 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.00112196762073451 0.00348593869935636 1.48509862778731 0.636363636363636 23.1 23 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0215869824633295 0.0444548133796206 1.48509862778731 0.636363636363636 23.1 23 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0215869824633295 0.0444548133796206 1.48509862778731 0.636363636363636 23.1 23 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0215869824633295 0.0444548133796206 1.48509862778731 0.636363636363636 23.1 23 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0215869824633295 0.0444548133796206 1.48509862778731 0.636363636363636 23.1 23 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0215869824633295 0.0444548133796206 1.48509862778731 0.636363636363636 23.1 23 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0215869824633295 0.0444548133796206 1.48509862778731 0.636363636363636 23.1 23 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000396137634066494 0.00141990895031894 1.46938329839273 0.62962962962963 23.1 23 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000396137634066494 0.00141990895031894 1.46938329839273 0.62962962962963 23.1 23 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000396137634066494 0.00141990895031894 1.46938329839273 0.62962962962963 23.1 23 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 5.79770458421783e-05 0.000257013508515326 1.46691374663073 0.628571428571429 23.1 23 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 5.79770458421783e-05 0.000257013508515326 1.46691374663073 0.628571428571429 23.1 23 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.19729172567548e-10 3.99100537336509e-09 1.46536309784993 0.627906976744186 23.1 23 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.13213832697638e-08 2.59129816237639e-07 1.4629329766263 0.626865671641791 23.1 23 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.87300360442248e-09 4.59224114509482e-08 1.46246855345912 0.626666666666667 23.1 23 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.87300360442248e-09 4.59224114509482e-08 1.46246855345912 0.626666666666667 23.1 23 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.87300360442248e-09 4.59224114509482e-08 1.46246855345912 0.626666666666667 23.1 23 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.87300360442248e-09 4.59224114509482e-08 1.46246855345912 0.626666666666667 23.1 23 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.87300360442248e-09 4.59224114509482e-08 1.46246855345912 0.626666666666667 23.1 23 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.000141348773831089 0.000555633439673038 1.45857900943396 0.625 23.1 23 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.000141348773831089 0.000555633439673038 1.45857900943396 0.625 23.1 23 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000978175953624432 0.00307952296904329 1.45857900943396 0.625 23.1 23 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000978175953624432 0.00307952296904329 1.45857900943396 0.625 23.1 23 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000978175953624432 0.00307952296904329 1.45857900943396 0.625 23.1 23 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00711067802056521 0.017208324529361 1.45857900943396 0.625 23.1 23 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00711067802056521 0.017208324529361 1.45857900943396 0.625 23.1 23 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00711067802056521 0.017208324529361 1.45857900943396 0.625 23.1 23 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.00711067802056521 0.017208324529361 1.45857900943396 0.625 23.1 23 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00711067802056521 0.017208324529361 1.45857900943396 0.625 23.1 23 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00711067802056521 0.017208324529361 1.45857900943396 0.625 23.1 23 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.057918354713812 0.104591140555526 1.45857900943396 0.625 23.1 23 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.057918354713812 0.104591140555526 1.45857900943396 0.625 23.1 23 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.057918354713812 0.104591140555526 1.45857900943396 0.625 23.1 23 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00242664367111662 0.00674506807876295 1.44468778077269 0.619047619047619 23.1 23 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.02198662572825e-06 6.79573349724906e-06 1.44266723842196 0.618181818181818 23.1 23 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 2.44198906846488e-06 1.51084801931544e-05 1.43613933236575 0.615384615384615 23.1 23 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0181904751144321 0.0384051128899657 1.43613933236575 0.615384615384615 23.1 23 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0181904751144321 0.0384051128899657 1.43613933236575 0.615384615384615 23.1 23 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.92265186512888e-16 1.1882667440224e-14 1.43273077382374 0.613924050632911 23.1 23 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.88395994846137e-08 1.60531437524582e-07 1.43135220125786 0.613333333333333 23.1 23 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.58256214079442e-09 2.68247147908792e-08 1.42769145394007 0.611764705882353 23.1 23 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.58256214079442e-09 2.68247147908792e-08 1.42769145394007 0.611764705882353 23.1 23 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.58256214079442e-09 2.68247147908792e-08 1.42769145394007 0.611764705882353 23.1 23 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.93108179397558e-25 1.8319529285515e-23 1.42716346153846 0.611538461538462 23.1 23 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000106869189882611 0.000433261701432922 1.42616614255765 0.611111111111111 23.1 23 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000106869189882611 0.000433261701432922 1.42616614255765 0.611111111111111 23.1 23 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00605421420890638 0.0149050983032418 1.42616614255765 0.611111111111111 23.1 23 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 7.80094726635709e-07 5.31136266029959e-06 1.42396866005756 0.610169491525424 23.1 23 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 7.80094726635709e-07 5.31136266029959e-06 1.42396866005756 0.610169491525424 23.1 23 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.3209711901353e-10 1.69346126447076e-09 1.42357311320755 0.61 23.1 23 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.24024310739535e-15 4.76990795087456e-14 1.4211795476536 0.608974358974359 23.1 23 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00207801511514891 0.00592588278328037 1.42052912223134 0.608695652173913 23.1 23 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.43687933009482e-08 1.26214770785489e-07 1.41796035347504 0.607594936708861 23.1 23 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.43687933009482e-08 1.26214770785489e-07 1.41796035347504 0.607594936708861 23.1 23 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000727074512820562 0.00235355437443872 1.41690532345013 0.607142857142857 23.1 23 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.53945763619922e-15 9.03412054077872e-14 1.41529214850883 0.606451612903226 23.1 23 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.48946694144189e-09 1.64303213773008e-08 1.40525461554068 0.602150537634409 23.1 23 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 5.52463521460371e-10 6.6623355172721e-09 1.40499855602618 0.602040816326531 23.1 23 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 7.62026731198242e-11 1.01342433504215e-09 1.40455756464011 0.601851851851852 23.1 23 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.06870149498627e-20 6.61200968419769e-19 1.40232887723158 0.600896860986547 23.1 23 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 7.93287846882263e-05 0.000337978624584868 1.4002358490566 0.6 23.1 23 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000621846172669023 0.00209688887134602 1.4002358490566 0.6 23.1 23 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00176943723216685 0.00508668521489582 1.4002358490566 0.6 23.1 23 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00176943723216685 0.00508668521489582 1.4002358490566 0.6 23.1 23 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.00512065998344848 0.0127167524545326 1.4002358490566 0.6 23.1 23 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00512065998344848 0.0127167524545326 1.4002358490566 0.6 23.1 23 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00512065998344848 0.0127167524545326 1.4002358490566 0.6 23.1 23 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00512065998344848 0.0127167524545326 1.4002358490566 0.6 23.1 23 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00512065998344848 0.0127167524545326 1.4002358490566 0.6 23.1 23 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00512065998344848 0.0127167524545326 1.4002358490566 0.6 23.1 23 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0152107695341607 0.0324511619896712 1.4002358490566 0.6 23.1 23 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0152107695341607 0.0324511619896712 1.4002358490566 0.6 23.1 23 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0152107695341607 0.0324511619896712 1.4002358490566 0.6 23.1 23 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0472980725388203 0.086957567471242 1.4002358490566 0.6 23.1 23 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 6.61478777121713e-11 9.66701696389418e-10 1.4002358490566 0.6 23.1 23 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 3.79158505066905e-06 2.25750022054479e-05 1.4002358490566 0.6 23.1 23 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.51503743828946e-33 5.11271182097987e-31 1.39773988497629 0.598930481283422 23.1 23 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.6168257787001e-07 1.21732438258743e-06 1.39375327568134 0.597222222222222 23.1 23 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.46052686706687e-05 0.000118689143452073 1.39030509835407 0.595744680851064 23.1 23 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 5.14473692222972e-08 4.0672003557405e-07 1.38841951277765 0.594936708860759 23.1 23 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.19462914526117e-14 3.77768283045921e-13 1.38565005896226 0.59375 23.1 23 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 7.48901938046025e-17 3.33027330574842e-15 1.38526006457472 0.593582887700535 23.1 23 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00150024859657896 0.00446622124044322 1.38294898672257 0.592592592592593 23.1 23 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00150024859657896 0.00446622124044322 1.38294898672257 0.592592592592593 23.1 23 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00150024859657896 0.00446622124044322 1.38294898672257 0.592592592592593 23.1 23 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 4.43163737348574e-08 3.52302792316772e-07 1.38294898672257 0.592592592592593 23.1 23 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 4.43163737348574e-08 3.52302792316772e-07 1.38294898672257 0.592592592592593 23.1 23 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.41103700410751e-08 1.25494103552812e-07 1.37902015437393 0.590909090909091 23.1 23 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.67023813820723e-09 1.82297574910812e-08 1.37689858490566 0.59 23.1 23 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 4.49873393838215e-09 4.38472492761493e-08 1.37567030784508 0.589473684210526 23.1 23 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.33897954837858e-10 6.49347683533565e-09 1.37406321636396 0.588785046728972 23.1 23 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.37058546475608e-11 4.32479886711269e-10 1.37388732501522 0.588709677419355 23.1 23 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.37058546475608e-11 4.32479886711269e-10 1.37388732501522 0.588709677419355 23.1 23 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.37058546475608e-11 4.32479886711269e-10 1.37388732501522 0.588709677419355 23.1 23 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000449918285418565 0.0015913180705467 1.37278024417314 0.588235294117647 23.1 23 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0126620779712705 0.0275506681240335 1.37278024417314 0.588235294117647 23.1 23 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0126620779712705 0.0275506681240335 1.37278024417314 0.588235294117647 23.1 23 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0126620779712705 0.0275506681240335 1.37278024417314 0.588235294117647 23.1 23 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.807435597826e-08 2.33624611444818e-07 1.36804651919323 0.586206896551724 23.1 23 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.31651024911707e-09 3.32351696091098e-08 1.367233657328 0.585858585858586 23.1 23 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000137009249837688 0.000541567118108418 1.36608375517717 0.585365853658537 23.1 23 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000137009249837688 0.000541567118108418 1.36608375517717 0.585365853658537 23.1 23 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000137009249837688 0.000541567118108418 1.36608375517717 0.585365853658537 23.1 23 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.20941399800752e-16 1.26861003310131e-14 1.36134040880503 0.583333333333333 23.1 23 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 4.21742229039835e-05 0.000193593287717318 1.36134040880503 0.583333333333333 23.1 23 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00361778994128318 0.00961511949249848 1.36134040880503 0.583333333333333 23.1 23 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00361778994128318 0.00961511949249848 1.36134040880503 0.583333333333333 23.1 23 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0385497969990246 0.0725830630202558 1.36134040880503 0.583333333333333 23.1 23 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 4.12854557895617e-12 8.15961160952031e-11 1.35994129224922 0.58273381294964 23.1 23 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.50356063015358e-06 9.55163739602026e-06 1.35843776401014 0.582089552238806 23.1 23 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.50356063015358e-06 9.55163739602026e-06 1.35843776401014 0.582089552238806 23.1 23 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 9.24485536063133e-11 1.19594810710713e-09 1.35815225796474 0.581967213114754 23.1 23 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 6.1143640169585e-15 2.0234279060772e-13 1.3580441850549 0.581920903954802 23.1 23 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.54279410363924e-08 4.35767735330311e-07 1.35681768319438 0.581395348837209 23.1 23 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.95609205181276e-11 5.32470758193614e-10 1.35681768319438 0.581395348837209 23.1 23 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00106865972762718 0.00334220393937027 1.35506695069994 0.580645161290323 23.1 23 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.10758635602677e-13 7.24933669610835e-12 1.35266945078716 0.579617834394904 23.1 23 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.010511978963476 0.0238469563381318 1.35110476663356 0.578947368421053 23.1 23 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.010511978963476 0.0238469563381318 1.35110476663356 0.578947368421053 23.1 23 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.010511978963476 0.0238469563381318 1.35110476663356 0.578947368421053 23.1 23 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 9.84500956959695e-05 0.00040141686583199 1.34837526205451 0.577777777777778 23.1 23 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 4.07195168144899e-09 4.02388002965411e-08 1.34638062409289 0.576923076923077 23.1 23 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00302872352313013 0.00819367599508397 1.34638062409289 0.576923076923077 23.1 23 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00302872352313013 0.00819367599508397 1.34638062409289 0.576923076923077 23.1 23 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.29647570748778e-09 1.44131635293368e-08 1.34557198708142 0.576576576576577 23.1 23 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 6.21881776381333e-14 1.70180339959738e-12 1.34532463928968 0.576470588235294 23.1 23 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000898947502088992 0.00288108625106449 1.34366066323613 0.575757575757576 23.1 23 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000898947502088992 0.00288108625106449 1.34366066323613 0.575757575757576 23.1 23 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000271828034281883 0.00098928719381872 1.34189268867925 0.575 23.1 23 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000271828034281883 0.00098928719381872 1.34189268867925 0.575 23.1 23 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.20600619330163e-13 2.95887381563485e-12 1.3394761080719 0.57396449704142 23.1 23 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.51620156904547e-09 2.68247147908792e-08 1.33658876500858 0.572727272727273 23.1 23 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00253114737492349 0.00700743718777457 1.33355795148248 0.571428571428571 23.1 23 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.00253114737492349 0.00700743718777457 1.33355795148248 0.571428571428571 23.1 23 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0314184408442222 0.0603352784363404 1.33355795148248 0.571428571428571 23.1 23 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0314184408442222 0.0603352784363404 1.33355795148248 0.571428571428571 23.1 23 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0314184408442222 0.0603352784363404 1.33355795148248 0.571428571428571 23.1 23 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 5.73990075157852e-06 3.09389347329403e-05 1.32842888243832 0.569230769230769 23.1 23 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000633201041149027 0.00212510632442232 1.32454742478327 0.567567567567568 23.1 23 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0021125734717882 0.00601238410070923 1.32244496855346 0.566666666666667 23.1 23 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.28825352705407e-06 8.40910444494471e-06 1.32039784011917 0.565789473684211 23.1 23 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 1.18137603882836e-18 6.46576193558752e-17 1.31786903440622 0.564705882352941 23.1 23 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.43690979610033e-07 2.48260032479735e-06 1.31786903440622 0.564705882352941 23.1 23 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 1.30957112170199e-05 6.67928210101053e-05 1.31742620206939 0.564516129032258 23.1 23 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.92547476236977e-12 3.91421512407454e-11 1.31719527723116 0.56441717791411 23.1 23 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 4.20667659709567e-05 0.000193593287717318 1.3153730703259 0.563636363636364 23.1 23 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.45945759868186e-06 2.06840679114466e-05 1.31477544512357 0.563380281690141 23.1 23 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0256251729087834 0.051796336717612 1.31272110849057 0.5625 23.1 23 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0256251729087834 0.051796336717612 1.31272110849057 0.5625 23.1 23 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0256251729087834 0.051796336717612 1.31272110849057 0.5625 23.1 23 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0256251729087834 0.051796336717612 1.31272110849057 0.5625 23.1 23 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0256251729087834 0.051796336717612 1.31272110849057 0.5625 23.1 23 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000444096481071685 0.00157593339791773 1.30916359871146 0.560975609756098 23.1 23 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000114182818511052 0.000457696199271062 1.30688679245283 0.56 23.1 23 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00597023884379487 0.0147238299388563 1.30688679245283 0.56 23.1 23 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00597023884379487 0.0147238299388563 1.30688679245283 0.56 23.1 23 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00597023884379487 0.0147238299388563 1.30688679245283 0.56 23.1 23 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.49367627636507e-08 1.30398855292484e-07 1.30603037908949 0.559633027522936 23.1 23 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00146771784320486 0.00440624998076059 1.30414123196448 0.558823529411765 23.1 23 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00146771784320486 0.00440624998076059 1.30414123196448 0.558823529411765 23.1 23 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00146771784320486 0.00440624998076059 1.30414123196448 0.558823529411765 23.1 23 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00146771784320486 0.00440624998076059 1.30414123196448 0.558823529411765 23.1 23 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 6.01349825451677e-29 8.55720801617737e-27 1.30381898308088 0.55868544600939 23.1 23 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000371489449989205 0.00134169920643309 1.30254497586661 0.558139534883721 23.1 23 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.47552432149351e-07 1.12281877512581e-06 1.30197368421053 0.557894736842105 23.1 23 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.47552432149351e-07 1.12281877512581e-06 1.30197368421053 0.557894736842105 23.1 23 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 9.57587524844252e-05 0.000394705833178363 1.30150126995646 0.557692307692308 23.1 23 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.53382569316495e-06 3.00558548144036e-05 1.29651467505241 0.555555555555556 23.1 23 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00122226031122148 0.00378927325243609 1.29651467505241 0.555555555555556 23.1 23 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0209219076742257 0.0435261324859987 1.29651467505241 0.555555555555556 23.1 23 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0209219076742257 0.0435261324859987 1.29651467505241 0.555555555555556 23.1 23 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0209219076742257 0.0435261324859987 1.29651467505241 0.555555555555556 23.1 23 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0987364311360198 0.159842936867527 1.29651467505241 0.555555555555556 23.1 23 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.91653583499646e-07 2.80061833829144e-06 1.29651467505241 0.555555555555556 23.1 23 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 5.76636811152757e-13 1.2066973268682e-11 1.29369616488925 0.554347826086957 23.1 23 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.48358796142313e-34 1.06335761151752e-31 1.29109199009972 0.553231939163498 23.1 23 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00408600198739874 0.0105332986015732 1.28757319453481 0.551724137931034 23.1 23 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.22247563244801e-09 3.25218640069043e-08 1.28630589808349 0.551181102362205 23.1 23 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.23905299037393e-05 6.34234678166222e-05 1.28524063439978 0.550724637681159 23.1 23 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.23905299037393e-05 6.34234678166222e-05 1.28524063439978 0.550724637681159 23.1 23 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.017101368827954 0.0363212654360874 1.28354952830189 0.55 23.1 23 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.017101368827954 0.0363212654360874 1.28354952830189 0.55 23.1 23 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 4.71310661909397e-05 0.000211569423311379 1.28354952830189 0.55 23.1 23 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.92213065047011e-09 2.07211508759012e-08 1.28091750602922 0.548872180451128 23.1 23 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 5.17760903746536e-07 3.64739488134317e-06 1.27978545343883 0.548387096774194 23.1 23 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 8.13330583871381e-28 9.64474517374146e-26 1.27674718673323 0.547085201793722 23.1 23 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 1.36338597079251e-06 8.77872505175449e-06 1.27294168096055 0.545454545454545 23.1 23 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.00279658440214391 0.00760906234082367 1.27294168096055 0.545454545454545 23.1 23 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00279658440214391 0.00760906234082367 1.27294168096055 0.545454545454545 23.1 23 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00279658440214391 0.00760906234082367 1.27294168096055 0.545454545454545 23.1 23 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0139944889204245 0.0301729662632789 1.27294168096055 0.545454545454545 23.1 23 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0139944889204245 0.0301729662632789 1.27294168096055 0.545454545454545 23.1 23 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0139944889204245 0.0301729662632789 1.27294168096055 0.545454545454545 23.1 23 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0781513806294092 0.135456047059256 1.27294168096055 0.545454545454545 23.1 23 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0781513806294092 0.135456047059256 1.27294168096055 0.545454545454545 23.1 23 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0781513806294092 0.135456047059256 1.27294168096055 0.545454545454545 23.1 23 1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0781513806294092 0.135456047059256 1.27294168096055 0.545454545454545 23.1 23 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00231412036089794 0.00653371681261463 1.26688005390836 0.542857142857143 23.1 23 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.6122372865004e-05 7.88389573433014e-05 1.2641018081761 0.541666666666667 23.1 23 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0114646872939493 0.0251763117581635 1.2641018081761 0.541666666666667 23.1 23 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0114646872939493 0.0251763117581635 1.2641018081761 0.541666666666667 23.1 23 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0114646872939493 0.0251763117581635 1.2641018081761 0.541666666666667 23.1 23 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.7962546184116e-12 1.69149598945942e-10 1.26250773275595 0.540983606557377 23.1 23 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 7.32227030797922e-05 0.0003129006200677 1.26250773275595 0.540983606557377 23.1 23 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 7.32227030797922e-05 0.0003129006200677 1.26250773275595 0.540983606557377 23.1 23 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.86686365036749e-45 2.65654697447294e-42 1.26098917691397 0.54033290653009 23.1 23 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.000337189169307212 0.00122403109164327 1.26021226415094 0.54 23.1 23 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 6.10739152923836e-05 0.000269065577278829 1.25947139862234 0.53968253968254 23.1 23 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 6.10739152923836e-05 0.000269065577278829 1.25947139862234 0.53968253968254 23.1 23 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.60007516506165e-31 5.69211884431415e-29 1.25863896544414 0.539325842696629 23.1 23 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00940200671790374 0.0218070982190832 1.25662191582003 0.538461538461538 23.1 23 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.062302339197716 0.110820285847937 1.25662191582003 0.538461538461538 23.1 23 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.062302339197716 0.110820285847937 1.25662191582003 0.538461538461538 23.1 23 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.062302339197716 0.110820285847937 1.25662191582003 0.538461538461538 23.1 23 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.062302339197716 0.110820285847937 1.25662191582003 0.538461538461538 23.1 23 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.062302339197716 0.110820285847937 1.25662191582003 0.538461538461538 23.1 23 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.062302339197716 0.110820285847937 1.25662191582003 0.538461538461538 23.1 23 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 3.54235428500351e-05 0.000165271152379016 1.25141851244189 0.536231884057971 23.1 23 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.54235428500351e-05 0.000165271152379016 1.25141851244189 0.536231884057971 23.1 23 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00771797465023711 0.018646312270437 1.25021057951482 0.535714285714286 23.1 23 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.89269759944693e-10 9.43807452438066e-09 1.24967285453439 0.535483870967742 23.1 23 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.000134233510158219 0.000535054019482202 1.24465408805031 0.533333333333333 23.1 23 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00634134886238225 0.0155313931689672 1.24465408805031 0.533333333333333 23.1 23 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00634134886238225 0.0155313931689672 1.24465408805031 0.533333333333333 23.1 23 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0499414937700068 0.0911112123522048 1.24465408805031 0.533333333333333 23.1 23 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0499414937700068 0.0911112123522048 1.24465408805031 0.533333333333333 23.1 23 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0499414937700068 0.0911112123522048 1.24465408805031 0.533333333333333 23.1 23 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0499414937700068 0.0911112123522048 1.24465408805031 0.533333333333333 23.1 23 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.36793704757111e-15 1.16892058992529e-13 1.24286579194679 0.532567049808429 23.1 23 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 7.34930706415878e-17 3.33027330574842e-15 1.2425301049649 0.532423208191126 23.1 23 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 5.62022530720595e-13 1.2066973268682e-11 1.24111813893654 0.531818181818182 23.1 23 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00521467941233661 0.0129276808427787 1.23979215801887 0.53125 23.1 23 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000618671520363864 0.0020911391294009 1.23830381209087 0.530612244897959 23.1 23 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 9.9275636400107e-06 5.15581133566979e-05 1.23715617185724 0.530120481927711 23.1 23 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 1.2969062053772e-06 8.42692936188015e-06 1.236875 0.53 23.1 23 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.000512904434162818 0.00178887992601395 1.23550221975583 0.529411764705882 23.1 23 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 5.3514317317144e-05 0.000239468155793383 1.23354110512129 0.528571428571429 23.1 23 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.89906301591985e-13 6.87561111942324e-12 1.23196716333306 0.527896995708155 23.1 23 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 3.66758007140641e-07 2.63584163717743e-06 1.22827706057597 0.526315789473684 23.1 23 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0029128614877158 0.00791030896377783 1.22827706057597 0.526315789473684 23.1 23 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0324884951306142 0.0621386136705161 1.22827706057597 0.526315789473684 23.1 23 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000242848984232349 0.00091908006532615 1.22619523504957 0.525423728813559 23.1 23 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000201555780037863 0.000781509196168606 1.22424992267244 0.524590163934426 23.1 23 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.48747800956221e-07 1.12589425936544e-06 1.223324330493 0.524193548387097 23.1 23 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.34600143770596e-06 8.7061820266163e-06 1.22242812219227 0.523809523809524 23.1 23 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00198209761746385 0.00566724155923079 1.22242812219227 0.523809523809524 23.1 23 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0263289246321567 0.0529181634909026 1.22242812219227 0.523809523809524 23.1 23 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0263289246321567 0.0529181634909026 1.22242812219227 0.523809523809524 23.1 23 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00135172351098983 0.0041276878887093 1.217596390484 0.521739130434783 23.1 23 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00135172351098983 0.0041276878887093 1.217596390484 0.521739130434783 23.1 23 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0213910754940636 0.0444372269022665 1.217596390484 0.521739130434783 23.1 23 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00111709548320485 0.00347839578249562 1.21548250786164 0.520833333333333 23.1 23 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 3.15269526600617e-07 2.2889211038402e-06 1.21508069546234 0.520661157024793 23.1 23 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 3.42970836636143e-06 2.05927215414866e-05 1.21353773584906 0.52 23.1 23 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000923610734008569 0.00292716720377326 1.21353773584906 0.52 23.1 23 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0174170064482834 0.03689049251874 1.21353773584906 0.52 23.1 23 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0142079800649949 0.0305407184780782 1.21008036338225 0.518518518518518 23.1 23 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0142079800649949 0.0305407184780782 1.21008036338225 0.518518518518518 23.1 23 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.37726042081582e-06 8.82811521991399e-06 1.20929459691252 0.518181818181818 23.1 23 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000523296513099805 0.0018206624404426 1.208536893531 0.517857142857143 23.1 23 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0116093739318496 0.0254547597920216 1.20709986987638 0.517241379310345 23.1 23 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 5.70919866121529e-13 1.2066973268682e-11 1.20390648397724 0.515873015873016 23.1 23 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 5.70919866121529e-13 1.2066973268682e-11 1.20390648397724 0.515873015873016 23.1 23 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 5.70919866121529e-13 1.2066973268682e-11 1.20390648397724 0.515873015873016 23.1 23 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000246537429886581 0.000923217796654221 1.20332768278302 0.515625 23.1 23 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000246537429886581 0.000923217796654221 1.20332768278302 0.515625 23.1 23 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 6.34404340145091e-11 9.66701696389418e-10 1.20020215633423 0.514285714285714 23.1 23 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00638531813747644 0.0156122125595 1.20020215633423 0.514285714285714 23.1 23 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.89412562875368e-06 1.76752822734613e-05 1.19957899841298 0.514018691588785 23.1 23 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.000116680770057933 0.000466395325259658 1.19927607442348 0.513888888888889 23.1 23 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 6.7026960253037e-07 4.65265192390594e-06 1.19532328578003 0.51219512195122 23.1 23 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00198333541566896 0.00566724155923079 1.19169008430349 0.51063829787234 23.1 23 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000921900275127479 0.00292716720377326 1.18807890222985 0.509090909090909 23.1 23 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000921900275127479 0.00292716720377326 1.18807890222985 0.509090909090909 23.1 23 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000921900275127479 0.00292716720377326 1.18807890222985 0.509090909090909 23.1 23 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000630384598454817 0.00212065551678772 1.18664055004797 0.508474576271186 23.1 23 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.000203384129770242 0.000783076205701454 1.18329790061121 0.507042253521127 23.1 23 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 7.69641353664571e-39 2.19039929252937e-36 1.18270297959532 0.506787330316742 23.1 23 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 9.62494196155249e-05 0.000394705833178363 1.18163362789587 0.506329113924051 23.1 23 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 9.62494196155249e-05 0.000394705833178363 1.18163362789587 0.506329113924051 23.1 23 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.57192917672463e-05 0.000207192841352839 1.18027542832357 0.505747126436782 23.1 23 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.57192917672463e-05 0.000207192841352839 1.18027542832357 0.505747126436782 23.1 23 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.62629788326781e-43 1.2457406292967e-40 1.17971155117382 0.505505505505506 23.1 23 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 3.86981490499729e-10 4.74719535328547e-09 1.17797619047619 0.504761904761905 23.1 23 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000240408479887771 0.000912270045014129 1.16686320754717 0.5 23.1 23 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000240408479887771 0.000912270045014129 1.16686320754717 0.5 23.1 23 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000350140329478677 0.00126781091309964 1.16686320754717 0.5 23.1 23 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.0010910011905047 0.00340459362738639 1.16686320754717 0.5 23.1 23 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00159909857115527 0.00467252005493625 1.16686320754717 0.5 23.1 23 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00159909857115527 0.00467252005493625 1.16686320754717 0.5 23.1 23 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0112762514403823 0.024878430264989 1.16686320754717 0.5 23.1 23 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0112762514403823 0.024878430264989 1.16686320754717 0.5 23.1 23 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0206979854797528 0.0432499755325818 1.16686320754717 0.5 23.1 23 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0206979854797528 0.0432499755325818 1.16686320754717 0.5 23.1 23 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.025432006178663 0.0517735976999105 1.16686320754717 0.5 23.1 23 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0313174636941779 0.0603352784363404 1.16686320754717 0.5 23.1 23 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0386633603438889 0.0725830630202558 1.16686320754717 0.5 23.1 23 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0386633603438889 0.0725830630202558 1.16686320754717 0.5 23.1 23 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0478756214332745 0.0879058184510318 1.16686320754717 0.5 23.1 23 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0594954017527453 0.107031550814357 1.16686320754717 0.5 23.1 23 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0594954017527453 0.107031550814357 1.16686320754717 0.5 23.1 23 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0594954017527453 0.107031550814357 1.16686320754717 0.5 23.1 23 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0742578146312301 0.129337662448275 1.16686320754717 0.5 23.1 23 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0742578146312301 0.129337662448275 1.16686320754717 0.5 23.1 23 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0742578146312301 0.129337662448275 1.16686320754717 0.5 23.1 23 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0931862375512099 0.15329944050332 1.16686320754717 0.5 23.1 23 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0931862375512099 0.15329944050332 1.16686320754717 0.5 23.1 23 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0931862375512099 0.15329944050332 1.16686320754717 0.5 23.1 23 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0931862375512099 0.15329944050332 1.16686320754717 0.5 23.1 23 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0931862375512099 0.15329944050332 1.16686320754717 0.5 23.1 23 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.117752964259794 0.18722063479518 1.16686320754717 0.5 23.1 23 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.117752964259794 0.18722063479518 1.16686320754717 0.5 23.1 23 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.117752964259794 0.18722063479518 1.16686320754717 0.5 23.1 23 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.117752964259794 0.18722063479518 1.16686320754717 0.5 23.1 23 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.117752964259794 0.18722063479518 1.16686320754717 0.5 23.1 23 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.150174789733219 0.231025649503104 1.16686320754717 0.5 23.1 23 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 7.25784478814773e-21 4.69450596978828e-19 1.16686320754717 0.5 23.1 23 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 5.39967148250242e-05 0.000240869357981221 1.16686320754717 0.5 23.1 23 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 9.43683189297311e-05 0.000392649467359671 1.16686320754717 0.5 23.1 23 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 9.43683189297311e-05 0.000392649467359671 1.16686320754717 0.5 23.1 23 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00345925311866437 0.00925285185687857 1.16686320754717 0.5 23.1 23 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00345925311866437 0.00925285185687857 1.16686320754717 0.5 23.1 23 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.72155205451914e-06 3.09389347329403e-05 1.1570576343745 0.495798319327731 23.1 23 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.000718800998395842 0.00234599500164514 1.14944733877781 0.492537313432836 23.1 23 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00225211121375349 0.00637128082936623 1.14564751286449 0.490909090909091 23.1 23 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00225211121375349 0.00637128082936623 1.14564751286449 0.490909090909091 23.1 23 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00225211121375349 0.00637128082936623 1.14564751286449 0.490909090909091 23.1 23 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00401433205562319 0.0103840736508462 1.14304967269927 0.489795918367347 23.1 23 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00401433205562319 0.0103840736508462 1.14304967269927 0.489795918367347 23.1 23 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.000268247323944357 0.000981274915097224 1.13840312931431 0.48780487804878 23.1 23 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00876292675521343 0.0204085839159881 1.13840312931431 0.48780487804878 23.1 23 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0106752087978122 0.0240361109482385 1.13694363812288 0.487179487179487 23.1 23 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.000470234000542262 0.00165629451181099 1.13615628103277 0.486842105263158 23.1 23 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0130187126199464 0.0281973029804926 1.13532636409995 0.486486486486487 23.1 23 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0130187126199464 0.0281973029804926 1.13532636409995 0.486486486486487 23.1 23 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.01589546622646 0.0338611503596595 1.13352425876011 0.485714285714286 23.1 23 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.07689069303822e-06 3.23873238059677e-05 1.13150371640938 0.484848484848485 23.1 23 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0194334231744118 0.0409685350773155 1.13150371640938 0.484848484848485 23.1 23 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00176100949737804 0.00508299495896338 1.12922245891662 0.483870967741935 23.1 23 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.00257693603377263 0.00705188456934317 1.12662654521796 0.482758620689655 23.1 23 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00257693603377263 0.00705188456934317 1.12662654521796 0.482758620689655 23.1 23 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.00257693603377263 0.00705188456934317 1.12662654521796 0.482758620689655 23.1 23 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00257693603377263 0.00705188456934317 1.12662654521796 0.482758620689655 23.1 23 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00257693603377263 0.00705188456934317 1.12662654521796 0.482758620689655 23.1 23 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00257693603377263 0.00705188456934317 1.12662654521796 0.482758620689655 23.1 23 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.029180689591129 0.0570386281430998 1.12662654521796 0.482758620689655 23.1 23 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.029180689591129 0.0570386281430998 1.12662654521796 0.482758620689655 23.1 23 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.79314006584929e-05 0.00017639340894456 1.12518952156334 0.482142857142857 23.1 23 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0358543161413548 0.0683923483500641 1.12364605171209 0.481481481481481 23.1 23 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0358543161413548 0.0683923483500641 1.12364605171209 0.481481481481481 23.1 23 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00817835486291868 0.0193226595446934 1.11613002461034 0.478260869565217 23.1 23 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00817835486291868 0.0193226595446934 1.11613002461034 0.478260869565217 23.1 23 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0544962881228952 0.0989135433659183 1.11613002461034 0.478260869565217 23.1 23 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.012084130336159 0.0264549499513142 1.11129829290207 0.476190476190476 23.1 23 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0674635276161089 0.119701496007136 1.11129829290207 0.476190476190476 23.1 23 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0674635276161089 0.119701496007136 1.11129829290207 0.476190476190476 23.1 23 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0147079112319288 0.0315201169925221 1.10852004716981 0.475 23.1 23 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000186200588413298 0.000723943817792685 1.10793072231751 0.474747474747475 23.1 23 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.00105622093824591 0.00331057796282805 1.10544935451837 0.473684210526316 23.1 23 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0838016177126635 0.141458721239763 1.10544935451837 0.473684210526316 23.1 23 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00622980349796645 0.0153108987523424 1.10081434674261 0.471698113207547 23.1 23 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.4652291325593e-18 1.82630409467847e-16 1.09942627961537 0.471103327495622 23.1 23 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.104523734558114 0.167660339462879 1.09822419533851 0.470588235294118 23.1 23 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.104523734558114 0.167660339462879 1.09822419533851 0.470588235294118 23.1 23 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.104523734558114 0.167660339462879 1.09822419533851 0.470588235294118 23.1 23 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.104523734558114 0.167660339462879 1.09822419533851 0.470588235294118 23.1 23 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.104523734558114 0.167660339462879 1.09822419533851 0.470588235294118 23.1 23 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.104523734558114 0.167660339462879 1.09822419533851 0.470588235294118 23.1 23 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.104523734558114 0.167660339462879 1.09822419533851 0.470588235294118 23.1 23 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00081311818864189 0.00261779905528826 1.0965702432371 0.469879518072289 23.1 23 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0399460688572145 0.0746954743545548 1.08907232704403 0.466666666666667 23.1 23 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.131025388359762 0.203769538399936 1.08907232704403 0.466666666666667 23.1 23 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.131025388359762 0.203769538399936 1.08907232704403 0.466666666666667 23.1 23 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.79094081385285e-45 2.6972543890563e-42 1.08776660535708 0.466107165913493 23.1 23 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0489898027147433 0.0898356820400512 1.08351583557951 0.464285714285714 23.1 23 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0198422160072738 0.0415839077737122 1.0814829728486 0.463414634146341 23.1 23 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0198422160072738 0.0415839077737122 1.0814829728486 0.463414634146341 23.1 23 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0198422160072738 0.0415839077737122 1.0814829728486 0.463414634146341 23.1 23 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0198422160072738 0.0415839077737122 1.0814829728486 0.463414634146341 23.1 23 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.00834328377674439 0.0194631029742742 1.08042889587701 0.462962962962963 23.1 23 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0241274751868693 0.0494717538773991 1.07710449927431 0.461538461538462 23.1 23 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0601914968432958 0.107874685148627 1.07710449927431 0.461538461538462 23.1 23 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0601914968432958 0.107874685148627 1.07710449927431 0.461538461538462 23.1 23 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.16528207145586 0.247836024954361 1.07710449927431 0.461538461538462 23.1 23 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.16528207145586 0.247836024954361 1.07710449927431 0.461538461538462 23.1 23 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.16528207145586 0.247836024954361 1.07710449927431 0.461538461538462 23.1 23 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.16528207145586 0.247836024954361 1.07710449927431 0.461538461538462 23.1 23 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.15365813093299e-18 2.0381570759716e-16 1.07431262654421 0.460342146189736 23.1 23 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0122029700259655 0.0266740804100598 1.0735141509434 0.46 23.1 23 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.75878204733015e-08 1.51681627475806e-07 1.06997564879777 0.458483754512635 23.1 23 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00326528481349978 0.00876698167850978 1.06962460691824 0.458333333333333 23.1 23 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00326528481349978 0.00876698167850978 1.06962460691824 0.458333333333333 23.1 23 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0741091395625794 0.129337662448275 1.06962460691824 0.458333333333333 23.1 23 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0741091395625794 0.129337662448275 1.06962460691824 0.458333333333333 23.1 23 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 9.5792111289854e-05 0.000394705833178363 1.06888232752413 0.458015267175573 23.1 23 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 9.5792111289854e-05 0.000394705833178363 1.06888232752413 0.458015267175573 23.1 23 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000904620433209163 0.00289275253136323 1.06755570052188 0.457446808510638 23.1 23 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0436178063596182 0.0812410189132678 1.06078473413379 0.454545454545455 23.1 23 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0914636670096254 0.151340462970578 1.06078473413379 0.454545454545455 23.1 23 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0914636670096254 0.151340462970578 1.06078473413379 0.454545454545455 23.1 23 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.210194297319728 0.305522456676172 1.06078473413379 0.454545454545455 23.1 23 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.210194297319728 0.305522456676172 1.06078473413379 0.454545454545455 23.1 23 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.210194297319728 0.305522456676172 1.06078473413379 0.454545454545455 23.1 23 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.210194297319728 0.305522456676172 1.06078473413379 0.454545454545455 23.1 23 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.210194297319728 0.305522456676172 1.06078473413379 0.454545454545455 23.1 23 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.210194297319728 0.305522456676172 1.06078473413379 0.454545454545455 23.1 23 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.210194297319728 0.305522456676172 1.06078473413379 0.454545454545455 23.1 23 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.210194297319728 0.305522456676172 1.06078473413379 0.454545454545455 23.1 23 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.02625106938776 0.0529111497716466 1.05573337825696 0.452380952380952 23.1 23 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.02625106938776 0.0529111497716466 1.05573337825696 0.452380952380952 23.1 23 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0042655775287294 0.0107488906561204 1.05497221504265 0.452054794520548 23.1 23 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0318343911500024 0.0609695001432751 1.05017688679245 0.45 23.1 23 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.91090007231457e-05 0.000138535478357981 1.04474961605968 0.447674418604651 23.1 23 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0386283841776008 0.0725830630202558 1.04403550148957 0.447368421052632 23.1 23 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00412732580136111 0.0106205870078424 1.03721174004193 0.444444444444444 23.1 23 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0796612414048483 0.137071277532163 1.03721174004193 0.444444444444444 23.1 23 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0796612414048483 0.137071277532163 1.03721174004193 0.444444444444444 23.1 23 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.140546400802409 0.218337913036931 1.03721174004193 0.444444444444444 23.1 23 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000588851792926254 0.00199984749721732 1.03296087225487 0.442622950819672 23.1 23 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0127551619065035 0.0277108326609993 1.03296087225487 0.442622950819672 23.1 23 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.90681100033027e-08 3.14089946523727e-07 1.03084847783308 0.441717791411043 23.1 23 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.74775898195396e-05 8.48826290553069e-05 1.03063044727517 0.441624365482233 23.1 23 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0976495202918284 0.159842936867527 1.02683962264151 0.44 23.1 23 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0976495202918284 0.159842936867527 1.02683962264151 0.44 23.1 23 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.000110578873781901 0.000444502083027246 1.02456281638288 0.439024390243902 23.1 23 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.175177945704176 0.262398122881098 1.02100530660377 0.4375 23.1 23 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.11990011230711 0.189625402285342 1.01466365873667 0.434782608695652 23.1 23 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.11990011230711 0.189625402285342 1.01466365873667 0.434782608695652 23.1 23 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.75525068591129e-05 0.000293967025261522 1.00885048152516 0.432291666666667 23.1 23 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.0317469996814351 0.0608840708176309 1.00670551239364 0.431372549019608 23.1 23 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.219353946884348 0.310897078104011 1.00016846361186 0.428571428571429 23.1 23 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.219353946884348 0.310897078104011 1.00016846361186 0.428571428571429 23.1 23 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.219353946884348 0.310897078104011 1.00016846361186 0.428571428571429 23.1 23 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.219353946884348 0.310897078104011 1.00016846361186 0.428571428571429 23.1 23 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0728990706422878 0.127752927985192 1.00016846361186 0.428571428571429 23.1 23 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.0010276118975008 0.00322801706433475 0.993075070252911 0.425531914893617 23.1 23 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0398182640135466 0.0745544601201011 0.987345791001451 0.423076923076923 23.1 23 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.125118737487419 0.196332242706721 0.987345791001451 0.423076923076923 23.1 23 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.000637710617233545 0.00213520519605491 0.98567326848705 0.422360248447205 23.1 23 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.000780185395012471 0.0025174689730221 0.979588865595155 0.419753086419753 23.1 23 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0145105746463582 0.031144114210811 0.979588865595155 0.419753086419753 23.1 23 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.106740895815014 0.17085747440356 0.978659464394401 0.419354838709677 23.1 23 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0568364470356474 0.103029635836594 0.972386006289308 0.416666666666667 23.1 23 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0274517910610352 0.0544824249370335 0.966829514824798 0.414285714285714 23.1 23 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00178561376686254 0.00512283949646249 0.963603164942179 0.412903225806452 23.1 23 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.22463589350642 0.317750374214349 0.960946170921199 0.411764705882353 23.1 23 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0942035940122745 0.154615587404229 0.957426221577165 0.41025641025641 23.1 23 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0942035940122745 0.154615587404229 0.957426221577165 0.41025641025641 23.1 23 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.186285381229683 0.278157499989337 0.954706260720412 0.409090909090909 23.1 23 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00141469712575959 0.0043107366380212 0.946105303416624 0.405405405405405 23.1 23 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.0174212304796861 0.03689049251874 0.942919763674481 0.404040404040404 23.1 23 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 7.19904729432648e-07 4.97293412612941e-06 0.938205164856108 0.402020202020202 23.1 23 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.227561813485296 0.321569474269688 0.933490566037736 0.4 23.1 23 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.278239652567405 0.383286568831963 0.933490566037736 0.4 23.1 23 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.278239652567405 0.383286568831963 0.933490566037736 0.4 23.1 23 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.116653174328037 0.186514007942468 0.922636024572181 0.395348837209302 23.1 23 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.161072722700208 0.245475183696332 0.919346769582619 0.393939393939394 23.1 23 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.161072722700208 0.245475183696332 0.919346769582619 0.393939393939394 23.1 23 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.118028322856374 0.187448999357836 0.913197292863002 0.391304347826087 23.1 23 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.278147388863517 0.383286568831963 0.907560272536688 0.388888888888889 23.1 23 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.102309548484233 0.165439190333027 0.907560272536688 0.388888888888889 23.1 23 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00154996912255301 0.00460460555614391 0.906034961154273 0.388235294117647 23.1 23 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.119095462578178 0.188932935617332 0.904914324220254 0.387755102040816 23.1 23 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.192192322542794 0.284330439160369 0.903377967133293 0.387096774193548 23.1 23 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0110404522882459 0.0246633651588288 0.901992418103947 0.386503067484663 23.1 23 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0397359894317675 0.0744984360492821 0.897587082728592 0.384615384615385 23.1 23 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.345562414357782 0.458831855433795 0.897587082728592 0.384615384615385 23.1 23 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.345562414357782 0.458831855433795 0.897587082728592 0.384615384615385 23.1 23 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0400309158575731 0.0747558966736568 0.894231616998766 0.383177570093458 23.1 23 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.120480083476876 0.190280975346942 0.891059176672384 0.381818181818182 23.1 23 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0785817683095777 0.136036321538357 0.890500868917577 0.381578947368421 23.1 23 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00348075265984191 0.00929289124757042 0.890377547927559 0.381526104417671 23.1 23 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.276833895656036 0.382460809241301 0.889038634321653 0.380952380952381 23.1 23 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.228967607644525 0.323235025474364 0.885206571242681 0.379310344827586 23.1 23 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.104625707268473 0.167660339462879 0.883987278444826 0.378787878787879 23.1 23 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0278964289448221 0.0552877693432896 0.883482142857143 0.378571428571429 23.1 23 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0218659195539109 0.0448992835861691 0.88065147739409 0.377358490566038 23.1 23 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0218659195539109 0.0448992835861691 0.88065147739409 0.377358490566038 23.1 23 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0793951221187892 0.137057694010419 0.87857935627081 0.376470588235294 23.1 23 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0793951221187892 0.137057694010419 0.87857935627081 0.376470588235294 23.1 23 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.340076676685343 0.457399915806467 0.875147405660377 0.375 23.1 23 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.340076676685343 0.457399915806467 0.875147405660377 0.375 23.1 23 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.340076676685343 0.457399915806467 0.875147405660377 0.375 23.1 23 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0413843972250208 0.0771821720199274 0.868759468392783 0.372262773722628 23.1 23 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.191629521519943 0.284330439160369 0.868363317244406 0.372093023255814 23.1 23 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.120947093130434 0.190806777743467 0.866812668463612 0.371428571428571 23.1 23 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0534590532801475 0.0971548311847381 0.863662531570346 0.37007874015748 23.1 23 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0532282407038384 0.0968590620480332 0.857987652608213 0.367647058823529 23.1 23 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.119931737214903 0.189625402285342 0.856684380224504 0.367088607594937 23.1 23 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.269408966808798 0.373653956889785 0.855699685534591 0.366666666666667 23.1 23 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.269408966808798 0.373653956889785 0.855699685534591 0.366666666666667 23.1 23 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0529800710689192 0.0965309105391447 0.854604039330321 0.366197183098592 23.1 23 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.223534331335254 0.316506819393101 0.853802346985734 0.365853658536585 23.1 23 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0600350473008595 0.107866000390307 0.851724969012533 0.364963503649635 23.1 23 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.266382163520046 0.370177557313502 0.848627787307033 0.363636363636364 23.1 23 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.328575903899667 0.443188162321542 0.848627787307033 0.363636363636364 23.1 23 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.184238469150609 0.275390064707266 0.841671821837303 0.360655737704918 23.1 23 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.184238469150609 0.275390064707266 0.841671821837303 0.360655737704918 23.1 23 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.215308364170094 0.307294006265875 0.836618903524386 0.358490566037736 23.1 23 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.317309536822202 0.42880481566761 0.83347371967655 0.357142857142857 23.1 23 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.415678229620801 0.539699015283212 0.83347371967655 0.357142857142857 23.1 23 1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.415678229620801 0.539699015283212 0.83347371967655 0.357142857142857 23.1 23 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.415678229620801 0.539699015283212 0.83347371967655 0.357142857142857 23.1 23 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.253488666691717 0.355556412594586 0.829769392033543 0.355555555555556 23.1 23 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.3118781211551 0.421865557417973 0.828096469872185 0.354838709677419 23.1 23 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 2.24966816718899e-08 1.89424722006505e-07 0.827619075011505 0.354634146341463 23.1 23 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0794607150798282 0.137057694010419 0.825342268752876 0.353658536585366 23.1 23 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.403044376601119 0.524732065785355 0.823668146503885 0.352941176470588 23.1 23 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.301466838911325 0.408559344543633 0.819957929627741 0.351351351351351 23.1 23 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.391837619751084 0.510608912917393 0.816804245283019 0.35 23.1 23 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.321712029555772 0.434341762863248 0.794460056202328 0.340425531914894 23.1 23 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.310159204898397 0.419939627564623 0.792586329654681 0.339622641509434 23.1 23 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.247849856874954 0.349544446316214 0.78609731876862 0.336842105263158 23.1 23 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.422497119597236 0.548052325603343 0.777908805031447 0.333333333333333 23.1 23 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.435168363104484 0.561418477513764 0.777908805031447 0.333333333333333 23.1 23 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.46549287046992 0.593499534970947 0.777908805031447 0.333333333333333 23.1 23 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.385351503485623 0.502617038918462 0.762949020319303 0.326923076923077 23.1 23 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.385351503485623 0.502617038918462 0.762949020319303 0.326923076923077 23.1 23 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.445353062262869 0.573474163014044 0.755029134295228 0.323529411764706 23.1 23 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.458205987732771 0.585828500039293 0.752814972611077 0.32258064516129 23.1 23 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.488008662101308 0.611299582896269 0.746792452830189 0.32 23.1 23 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.488008662101308 0.611299582896269 0.746792452830189 0.32 23.1 23 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.488008662101308 0.611299582896269 0.746792452830189 0.32 23.1 23 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.488008662101308 0.611299582896269 0.746792452830189 0.32 23.1 23 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.488008662101308 0.611299582896269 0.746792452830189 0.32 23.1 23 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.526024462583087 0.638679872231854 0.736966236345581 0.315789473684211 23.1 23 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.526024462583087 0.638679872231854 0.736966236345581 0.315789473684211 23.1 23 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.539384855413042 0.649360955374584 0.718069666182874 0.307692307692308 23.1 23 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.583533109511089 0.693707280563308 0.700117924528302 0.3 23.1 23 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.593772267620942 0.705290431406177 0.686390122086571 0.294117647058824 23.1 23 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.611228535642456 0.724815171849346 0.686390122086571 0.294117647058824 23.1 23 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.603743296130776 0.716536038693991 0.680670204402516 0.291666666666667 23.1 23 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.613428377920652 0.726213462380272 0.67753347534997 0.290322580645161 23.1 23 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.613428377920652 0.726213462380272 0.67753347534997 0.290322580645161 23.1 23 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.701235139543602 0.807328158228596 0.649898495342727 0.278481012658228 23.1 23 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.66728071455497 0.773871602943539 0.648257337526206 0.277777777777778 23.1 23 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.714172341532182 0.819570356451851 0.642620317199891 0.27536231884058 23.1 23 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.695632878591698 0.801526790474483 0.636470840480274 0.272727272727273 23.1 23 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.785956598417975 0.88203173465992 0.625534915386112 0.268041237113402 23.1 23 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.879936471409143 0.963596651624895 0.614798894299046 0.263440860215054 23.1 23 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.731206050187229 0.838441748119603 0.608798195242002 0.260869565217391 23.1 23 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.767159504819408 0.86229697895578 0.608798195242002 0.260869565217391 23.1 23 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.765869687571841 0.861527719695438 0.600101078167116 0.257142857142857 23.1 23 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.765869687571841 0.861527719695438 0.600101078167116 0.257142857142857 23.1 23 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.762461464794304 0.859051990817335 0.583431603773585 0.25 23.1 23 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.771168062314024 0.866118510396887 0.583431603773585 0.25 23.1 23 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.972742455837307 1 0.583431603773585 0.25 23.1 23 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.840898552194982 0.93193040480799 0.571524836349634 0.244897959183673 23.1 23 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.993420210787938 1 0.571402086170006 0.244845360824742 23.1 23 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.835312190914703 0.931443323714439 0.570466457023061 0.244444444444444 23.1 23 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.89529372058196 0.971038844808025 0.558779564177518 0.23943661971831 23.1 23 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.801602372356248 0.89888114725212 0.555649146451033 0.238095238095238 23.1 23 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.848221061631852 0.939108899942351 0.552724677259186 0.236842105263158 23.1 23 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.986477923387468 1 0.548479480045213 0.235023041474654 23.1 23 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.840489617163631 0.93193040480799 0.544536163522013 0.233333333333333 23.1 23 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.872804193200473 0.95873228058817 0.542727073277753 0.232558139534884 23.1 23 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.892921787971443 0.969204961314541 0.534812303459119 0.229166666666667 23.1 23 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.892921787971443 0.969204961314541 0.534812303459119 0.229166666666667 23.1 23 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.865378253029559 0.953121713669553 0.526970480827754 0.225806451612903 23.1 23 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.865378253029559 0.953121713669553 0.526970480827754 0.225806451612903 23.1 23 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.865378253029559 0.953121713669553 0.526970480827754 0.225806451612903 23.1 23 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.8869805873355 0.964987705322447 0.510502653301887 0.21875 23.1 23 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.923437053155742 0.997760764343676 0.466745283018868 0.2 23.1 23 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999759902838815 1 0.437573702830189 0.1875 23.1 23 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.997668319385242 1 0.432171558350804 0.185185185185185 23.1 23 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.429123496982083 0.183879093198992 23.1 23 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.952600419900317 1 0.416736859838275 0.178571428571429 23.1 23 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.352380028318946 0.150994575045208 23.1 23 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999994867731136 1 0.259302935010482 0.111111111111111 23.1 23 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 6.20789243523995e-10 4.67398462187643e-09 1.417789181099 1 23.2 23 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 1.03310407962071e-05 4.0498818327831e-05 1.417789181099 1 23.2 23 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 2.49908164263481e-05 9.30940622374172e-05 1.417789181099 1 23.2 23 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 2.49908164263481e-05 9.30940622374172e-05 1.417789181099 1 23.2 23 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 2.49908164263481e-05 9.30940622374172e-05 1.417789181099 1 23.2 23 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00500284574792584 0.0119447139249974 1.417789181099 1 23.2 23 2 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.00500284574792584 0.0119447139249974 1.417789181099 1 23.2 23 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00500284574792584 0.0119447139249974 1.417789181099 1 23.2 23 2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.00500284574792584 0.0119447139249974 1.417789181099 1 23.2 23 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00500284574792584 0.0119447139249974 1.417789181099 1 23.2 23 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00500284574792584 0.0119447139249974 1.417789181099 1 23.2 23 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 8.79829942465704e-09 5.8232465494358e-08 1.417789181099 1 23.2 23 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 8.79829942465704e-09 5.8232465494358e-08 1.417789181099 1 23.2 23 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 3.01589941476052e-07 1.50056813538609e-06 1.417789181099 1 23.2 23 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 6.04503250689544e-05 0.000214515742077611 1.417789181099 1 23.2 23 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 6.04503250689544e-05 0.000214515742077611 1.417789181099 1 23.2 23 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000146217268696136 0.000486138255501405 1.417789181099 1 23.2 23 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000146217268696136 0.000486138255501405 1.417789181099 1 23.2 23 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000353655588919516 0.0011120793852854 1.417789181099 1 23.2 23 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.000353655588919516 0.0011120793852854 1.417789181099 1 23.2 23 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.000353655588919516 0.0011120793852854 1.417789181099 1 23.2 23 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.000353655588919516 0.0011120793852854 1.417789181099 1 23.2 23 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000855350706253604 0.00248229645172346 1.417789181099 1 23.2 23 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0020686629994298 0.00538154926542707 1.417789181099 1 23.2 23 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0020686629994298 0.00538154926542707 1.417789181099 1 23.2 23 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0020686629994298 0.00538154926542707 1.417789181099 1 23.2 23 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0020686629994298 0.00538154926542707 1.417789181099 1 23.2 23 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0020686629994298 0.00538154926542707 1.417789181099 1 23.2 23 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0020686629994298 0.00538154926542707 1.417789181099 1 23.2 23 2 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_199058.2 GRB7 EVENTS IN ERBB2 SIGNALING 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0120983548355837 0.0253175866632876 1.417789181099 1 23.2 23 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 7.99636546568959e-13 9.03081591879071e-12 1.37840614829069 0.972222222222222 23.2 23 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 9.36369927638974e-09 6.16877040291787e-08 1.36107761385504 0.96 23.2 23 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 2.17790309706905e-08 1.37130801200409e-07 1.35871463188654 0.958333333333333 23.2 23 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.71129038097753e-07 1.3585092296236e-06 1.35027541057047 0.952380952380952 23.2 23 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 6.2581026736282e-07 2.97835455002439e-06 1.34689972204405 0.95 23.2 23 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 6.2581026736282e-07 2.97835455002439e-06 1.34689972204405 0.95 23.2 23 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 7.5789347861648e-06 3.03797864808803e-05 1.33438981750494 0.941176470588235 23.2 23 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 1.72996535378803e-05 6.54718270861801e-05 1.32917735728031 0.9375 23.2 23 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 1.72996535378803e-05 6.54718270861801e-05 1.32917735728031 0.9375 23.2 23 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 1.72996535378803e-05 6.54718270861801e-05 1.32917735728031 0.9375 23.2 23 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 1.72996535378803e-05 6.54718270861801e-05 1.32917735728031 0.9375 23.2 23 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 1.72996535378803e-05 6.54718270861801e-05 1.32917735728031 0.9375 23.2 23 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.84485816118242e-09 1.96516172978766e-08 1.32326990235906 0.933333333333333 23.2 23 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 3.93449912148868e-05 0.000142462907121588 1.32326990235906 0.933333333333333 23.2 23 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 3.93449912148868e-05 0.000142462907121588 1.32326990235906 0.933333333333333 23.2 23 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 3.93449912148868e-05 0.000142462907121588 1.32326990235906 0.933333333333333 23.2 23 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 6.43773159111588e-09 4.32117549724429e-08 1.32001061688527 0.931034482758621 23.2 23 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 8.91166893841672e-05 0.000308547564461484 1.31651852530621 0.928571428571429 23.2 23 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 8.91166893841672e-05 0.000308547564461484 1.31651852530621 0.928571428571429 23.2 23 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 3.27267716600391e-08 2.02479113357546e-07 1.31276776027685 0.925925925925926 23.2 23 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 7.34931597227765e-08 4.21696638248028e-07 1.30872847486061 0.923076923076923 23.2 23 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000200908123988041 0.00065272205578763 1.30872847486061 0.923076923076923 23.2 23 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.43288336365205e-13 1.99901277105575e-12 1.30205128876438 0.918367346938776 23.2 23 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.19156016651129e-13 3.84116869290434e-12 1.29964008267408 0.916666666666667 23.2 23 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000450504920137627 0.00137568347930438 1.29964008267408 0.916666666666667 23.2 23 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000450504920137627 0.00137568347930438 1.29964008267408 0.916666666666667 23.2 23 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000450504920137627 0.00137568347930438 1.29964008267408 0.916666666666667 23.2 23 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000450504920137627 0.00137568347930438 1.29964008267408 0.916666666666667 23.2 23 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 8.16933767655012e-07 3.86211545306672e-06 1.29450316535126 0.91304347826087 23.2 23 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 1.81030936245997e-06 8.07545524382615e-06 1.28889925554454 0.909090909090909 23.2 23 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 1.81030936245997e-06 8.07545524382615e-06 1.28889925554454 0.909090909090909 23.2 23 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 1.81030936245997e-06 8.07545524382615e-06 1.28889925554454 0.909090909090909 23.2 23 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00100388670496795 0.00276847050614224 1.28889925554454 0.909090909090909 23.2 23 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3.64741537641144e-09 2.49532311568917e-08 1.28889925554454 0.909090909090909 23.2 23 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 3.99528194538097e-06 1.70729315563878e-05 1.28276164004195 0.904761904761905 23.2 23 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 3.99528194538097e-06 1.70729315563878e-05 1.28276164004195 0.904761904761905 23.2 23 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 3.99528194538097e-06 1.70729315563878e-05 1.28276164004195 0.904761904761905 23.2 23 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 8.7781379467696e-06 3.48918723414892e-05 1.2760102629891 0.9 23.2 23 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 8.7781379467696e-06 3.48918723414892e-05 1.2760102629891 0.9 23.2 23 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 8.7781379467696e-06 3.48918723414892e-05 1.2760102629891 0.9 23.2 23 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00222060047092994 0.00569353958582577 1.2760102629891 0.9 23.2 23 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00222060047092994 0.00569353958582577 1.2760102629891 0.9 23.2 23 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00222060047092994 0.00569353958582577 1.2760102629891 0.9 23.2 23 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00222060047092994 0.00569353958582577 1.2760102629891 0.9 23.2 23 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00222060047092994 0.00569353958582577 1.2760102629891 0.9 23.2 23 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00222060047092994 0.00569353958582577 1.2760102629891 0.9 23.2 23 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 9.02398559479555e-15 1.6896225659729e-13 1.27360723047876 0.898305084745763 23.2 23 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 9.02398559479555e-15 1.6896225659729e-13 1.27360723047876 0.898305084745763 23.2 23 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 1.919216355573e-05 7.20592315034401e-05 1.26854821466752 0.894736842105263 23.2 23 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 1.919216355573e-05 7.20592315034401e-05 1.26854821466752 0.894736842105263 23.2 23 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 4.86434757433042e-18 1.70493451995671e-16 1.2665583351151 0.893333333333333 23.2 23 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 4.14632192274711e-11 3.55434704582478e-10 1.26025704986577 0.888888888888889 23.2 23 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 4.01664999935683e-09 2.73478131535157e-08 1.26025704986577 0.888888888888889 23.2 23 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 4.17337567758539e-05 0.000150347179473519 1.26025704986577 0.888888888888889 23.2 23 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00486891164492631 0.0117431546961528 1.26025704986577 0.888888888888889 23.2 23 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00486891164492631 0.0117431546961528 1.26025704986577 0.888888888888889 23.2 23 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.00486891164492631 0.0117431546961528 1.26025704986577 0.888888888888889 23.2 23 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00486891164492631 0.0117431546961528 1.26025704986577 0.888888888888889 23.2 23 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00486891164492631 0.0117431546961528 1.26025704986577 0.888888888888889 23.2 23 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 3.99624264224673e-07 1.93423580949561e-06 1.26025704986577 0.888888888888889 23.2 23 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 3.99624264224673e-07 1.93423580949561e-06 1.26025704986577 0.888888888888889 23.2 23 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 3.99624264224673e-07 1.93423580949561e-06 1.26025704986577 0.888888888888889 23.2 23 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 8.94441673380525e-11 7.23176421148004e-10 1.25667677415593 0.886363636363636 23.2 23 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 8.6269876940334e-07 4.06496804258593e-06 1.25419812174142 0.884615384615385 23.2 23 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.33669896315986e-12 4.3154703668367e-11 1.25099045391088 0.882352941176471 23.2 23 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.33669896315986e-12 4.3154703668367e-11 1.25099045391088 0.882352941176471 23.2 23 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 9.02050441757469e-05 0.000310052603531613 1.25099045391088 0.882352941176471 23.2 23 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 9.02050441757469e-05 0.000310052603531613 1.25099045391088 0.882352941176471 23.2 23 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 9.02050441757469e-05 0.000310052603531613 1.25099045391088 0.882352941176471 23.2 23 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 4.12729151334244e-10 3.17466801269529e-09 1.24900475477769 0.880952380952381 23.2 23 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.85392388913561e-06 8.16759657659435e-06 1.24765447936712 0.88 23.2 23 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 1.85392388913561e-06 8.16759657659435e-06 1.24765447936712 0.88 23.2 23 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 1.85392388913561e-06 8.16759657659435e-06 1.24765447936712 0.88 23.2 23 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 1.85392388913561e-06 8.16759657659435e-06 1.24765447936712 0.88 23.2 23 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 8.82613937804293e-10 6.43554141273927e-09 1.24488806145278 0.878048780487805 23.2 23 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 8.82613937804293e-10 6.43554141273927e-09 1.24488806145278 0.878048780487805 23.2 23 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.88143559402446e-09 1.31239355406706e-08 1.24056553346162 0.875 23.2 23 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000193662354953931 0.000630621352630308 1.24056553346162 0.875 23.2 23 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000193662354953931 0.000630621352630308 1.24056553346162 0.875 23.2 23 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000193662354953931 0.000630621352630308 1.24056553346162 0.875 23.2 23 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000193662354953931 0.000630621352630308 1.24056553346162 0.875 23.2 23 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0105618490516632 0.0226689460037959 1.24056553346162 0.875 23.2 23 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.27937512949085e-15 4.76992766068453e-14 1.23550200067198 0.871428571428571 23.2 23 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.97657717405354e-21 1.41188977289273e-19 1.23347658755613 0.87 23.2 23 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.32699435066013e-20 5.90097800309177e-19 1.22971510605525 0.86734693877551 23.2 23 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000412632727484488 0.0012709445264295 1.22875062361913 0.866666666666667 23.2 23 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.000412632727484488 0.0012709445264295 1.22875062361913 0.866666666666667 23.2 23 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000412632727484488 0.0012709445264295 1.22875062361913 0.866666666666667 23.2 23 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000412632727484488 0.0012709445264295 1.22875062361913 0.866666666666667 23.2 23 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000412632727484488 0.0012709445264295 1.22875062361913 0.866666666666667 23.2 23 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000412632727484488 0.0012709445264295 1.22875062361913 0.866666666666667 23.2 23 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.14421371981094e-14 3.63240014677497e-13 1.22733988811555 0.865671641791045 23.2 23 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.14421371981094e-14 3.63240014677497e-13 1.22733988811555 0.865671641791045 23.2 23 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.14421371981094e-14 3.63240014677497e-13 1.22733988811555 0.865671641791045 23.2 23 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.78334416372138e-05 6.73129640577064e-05 1.22445429276731 0.863636363636364 23.2 23 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.07442989565285e-16 3.32372552503043e-15 1.22284316869788 0.8625 23.2 23 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 7.84467218937327e-08 4.42974941487229e-07 1.21524786951342 0.857142857142857 23.2 23 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 7.84467218937327e-08 4.42974941487229e-07 1.21524786951342 0.857142857142857 23.2 23 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 7.84467218937327e-08 4.42974941487229e-07 1.21524786951342 0.857142857142857 23.2 23 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 1.69134762507263e-06 7.73886710764743e-06 1.21524786951342 0.857142857142857 23.2 23 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.69134762507263e-06 7.73886710764743e-06 1.21524786951342 0.857142857142857 23.2 23 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 3.74752739551012e-05 0.0001367367047131 1.21524786951342 0.857142857142857 23.2 23 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000871656731611278 0.00248229645172346 1.21524786951342 0.857142857142857 23.2 23 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000871656731611278 0.00248229645172346 1.21524786951342 0.857142857142857 23.2 23 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000871656731611278 0.00248229645172346 1.21524786951342 0.857142857142857 23.2 23 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000871656731611278 0.00248229645172346 1.21524786951342 0.857142857142857 23.2 23 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000871656731611278 0.00248229645172346 1.21524786951342 0.857142857142857 23.2 23 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000871656731611278 0.00248229645172346 1.21524786951342 0.857142857142857 23.2 23 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.000871656731611278 0.00248229645172346 1.21524786951342 0.857142857142857 23.2 23 2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0226079422389021 0.0439464658486265 1.21524786951342 0.857142857142857 23.2 23 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.19476087873097e-31 4.97428727536181e-29 1.21398198631601 0.85625 23.2 23 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.91232012074666e-18 1.70493451995671e-16 1.21299741049581 0.855555555555556 23.2 23 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 3.67660424553291e-11 3.2096980622045e-10 1.2077463394547 0.851851851851852 23.2 23 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 3.52537717418066e-06 1.52480599357419e-05 1.2077463394547 0.851851851851852 23.2 23 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 7.82049753398395e-05 0.000274102659873378 1.20512080393415 0.85 23.2 23 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 7.82049753398395e-05 0.000274102659873378 1.20512080393415 0.85 23.2 23 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.6886470899152e-12 3.72265589287186e-11 1.20512080393415 0.85 23.2 23 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.6886470899152e-12 3.72265589287186e-11 1.20512080393415 0.85 23.2 23 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.6886470899152e-12 3.72265589287186e-11 1.20512080393415 0.85 23.2 23 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.6886470899152e-12 3.72265589287186e-11 1.20512080393415 0.85 23.2 23 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.6886470899152e-12 3.72265589287186e-11 1.20512080393415 0.85 23.2 23 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.6886470899152e-12 3.72265589287186e-11 1.20512080393415 0.85 23.2 23 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.6886470899152e-12 3.72265589287186e-11 1.20512080393415 0.85 23.2 23 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.86612933782782e-16 5.10673470717113e-15 1.20095083575444 0.847058823529412 23.2 23 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.86612933782782e-16 5.10673470717113e-15 1.20095083575444 0.847058823529412 23.2 23 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.86612933782782e-16 5.10673470717113e-15 1.20095083575444 0.847058823529412 23.2 23 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 7.30566204766314e-06 2.93671104345329e-05 1.19966776862223 0.846153846153846 23.2 23 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 7.30566204766314e-06 2.93671104345329e-05 1.19966776862223 0.846153846153846 23.2 23 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 7.30566204766314e-06 2.93671104345329e-05 1.19966776862223 0.846153846153846 23.2 23 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00182328729896034 0.00484618515032956 1.19966776862223 0.846153846153846 23.2 23 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00182328729896034 0.00484618515032956 1.19966776862223 0.846153846153846 23.2 23 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00182328729896034 0.00484618515032956 1.19966776862223 0.846153846153846 23.2 23 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00182328729896034 0.00484618515032956 1.19966776862223 0.846153846153846 23.2 23 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00182328729896034 0.00484618515032956 1.19966776862223 0.846153846153846 23.2 23 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00182328729896034 0.00484618515032956 1.19966776862223 0.846153846153846 23.2 23 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.56723777171091e-11 1.40262852147461e-10 1.19778741161812 0.844827586206897 23.2 23 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.56723777171091e-11 1.40262852147461e-10 1.19778741161812 0.844827586206897 23.2 23 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.56723777171091e-11 1.40262852147461e-10 1.19778741161812 0.844827586206897 23.2 23 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.56723777171091e-11 1.40262852147461e-10 1.19778741161812 0.844827586206897 23.2 23 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.22196643939602e-12 3.44726183703799e-11 1.19274327933725 0.841269841269841 23.2 23 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.23921463913226e-13 3.84116869290434e-12 1.19176481889481 0.840579710144927 23.2 23 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 8.67801630629143e-22 4.25821282891473e-20 1.19141947991512 0.840336134453782 23.2 23 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 6.60413501957304e-10 4.94614954360654e-09 1.19094291212316 0.84 23.2 23 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 3.26565634246779e-14 5.05111845144747e-13 1.19094291212316 0.84 23.2 23 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 3.26565634246779e-14 5.05111845144747e-13 1.19094291212316 0.84 23.2 23 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 3.26565634246779e-14 5.05111845144747e-13 1.19094291212316 0.84 23.2 23 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 3.26565634246779e-14 5.05111845144747e-13 1.19094291212316 0.84 23.2 23 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 3.26565634246779e-14 5.05111845144747e-13 1.19094291212316 0.84 23.2 23 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 6.58379436986332e-12 6.46119957814862e-11 1.18911350672819 0.838709677419355 23.2 23 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.39010417925364e-07 7.0900295594191e-07 1.18787742200186 0.837837837837838 23.2 23 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.36306622513087e-08 8.73713170432986e-08 1.18698629115265 0.837209302325581 23.2 23 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.34130169117996e-10 1.06037350363838e-09 1.18578731510098 0.836363636363636 23.2 23 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.34130169117996e-10 1.06037350363838e-09 1.18578731510098 0.836363636363636 23.2 23 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.34133519219392e-11 1.23942855746231e-10 1.18536472518113 0.836065573770492 23.2 23 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.34133519219392e-11 1.23942855746231e-10 1.18536472518113 0.836065573770492 23.2 23 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.36880332692895e-14 2.46557865091125e-13 1.18448210066498 0.835443037974684 23.2 23 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.36880332692895e-14 2.46557865091125e-13 1.18448210066498 0.835443037974684 23.2 23 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 3.07743142351461e-05 0.000112865590609827 1.18149098424916 0.833333333333333 23.2 23 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 3.07743142351461e-05 0.000112865590609827 1.18149098424916 0.833333333333333 23.2 23 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 3.07743142351461e-05 0.000112865590609827 1.18149098424916 0.833333333333333 23.2 23 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 3.07743142351461e-05 0.000112865590609827 1.18149098424916 0.833333333333333 23.2 23 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00377079562911959 0.00925145203489168 1.18149098424916 0.833333333333333 23.2 23 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00377079562911959 0.00925145203489168 1.18149098424916 0.833333333333333 23.2 23 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00377079562911959 0.00925145203489168 1.18149098424916 0.833333333333333 23.2 23 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00377079562911959 0.00925145203489168 1.18149098424916 0.833333333333333 23.2 23 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00377079562911959 0.00925145203489168 1.18149098424916 0.833333333333333 23.2 23 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00377079562911959 0.00925145203489168 1.18149098424916 0.833333333333333 23.2 23 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0475759002738729 0.0834778126876956 1.18149098424916 0.833333333333333 23.2 23 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.80935203091306e-15 5.71101134284184e-14 1.18149098424916 0.833333333333333 23.2 23 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.80935203091306e-15 5.71101134284184e-14 1.18149098424916 0.833333333333333 23.2 23 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.72432858447726e-11 2.40790035758456e-10 1.18149098424916 0.833333333333333 23.2 23 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.72553470602373e-10 2.11936387249824e-09 1.18149098424916 0.833333333333333 23.2 23 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 2.77377582487283e-08 1.72361703004106e-07 1.18149098424916 0.833333333333333 23.2 23 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.9265120841171e-06 1.27743150174805e-05 1.18149098424916 0.833333333333333 23.2 23 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.000332561481175214 0.00105869124767859 1.18149098424916 0.833333333333333 23.2 23 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000332561481175214 0.00105869124767859 1.18149098424916 0.833333333333333 23.2 23 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 5.68711213501544e-15 1.10859733809958e-13 1.17864401802206 0.831325301204819 23.2 23 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 5.57155404112684e-13 6.55233173596983e-12 1.17816284063156 0.830985915492958 23.2 23 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 5.51563694738921e-11 4.67187581912789e-10 1.17748593006527 0.830508474576271 23.2 23 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 5.51884112226488e-10 4.17729304094837e-09 1.17703252770483 0.830188679245283 23.2 23 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 5.55042496332173e-09 3.76107367752706e-08 1.17646336303959 0.829787234042553 23.2 23 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 5.61948458737295e-08 3.29075167400482e-07 1.17572761359429 0.829268292682927 23.2 23 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 5.61948458737295e-08 3.29075167400482e-07 1.17572761359429 0.829268292682927 23.2 23 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 5.61948458737295e-08 3.29075167400482e-07 1.17572761359429 0.829268292682927 23.2 23 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 5.61948458737295e-08 3.29075167400482e-07 1.17572761359429 0.829268292682927 23.2 23 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.38060741972353e-16 6.15928065139379e-15 1.17386846177014 0.827956989247312 23.2 23 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 5.04322446910696e-19 1.88855484724716e-17 1.17289832254553 0.827272727272727 23.2 23 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.31380964152553e-14 3.82854781382655e-13 1.17273919918065 0.827160493827161 23.2 23 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.31380964152553e-14 3.82854781382655e-13 1.17273919918065 0.827160493827161 23.2 23 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.09603900733495e-22 5.57022681227728e-21 1.17260759339015 0.827067669172932 23.2 23 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 6.24864261068046e-05 0.000221189513308415 1.17121714960352 0.826086956521739 23.2 23 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.24760718593452e-11 1.99896564099052e-10 1.17023868916108 0.825396825396825 23.2 23 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.1331657929197e-07 5.84237291059687e-07 1.16967607440667 0.825 23.2 23 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.1331657929197e-07 5.84237291059687e-07 1.16967607440667 0.825 23.2 23 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.92378074647175e-34 2.73754000222931e-32 1.16798823014346 0.823809523809524 23.2 23 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.23771997441955e-09 1.55330513346294e-08 1.16759109031682 0.823529411764706 23.2 23 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 1.15716623560333e-06 5.34625828981667e-06 1.16759109031682 0.823529411764706 23.2 23 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.15716623560333e-06 5.34625828981667e-06 1.16759109031682 0.823529411764706 23.2 23 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 9.31963495596447e-14 1.35324903493239e-12 1.16653540217006 0.822784810126582 23.2 23 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 9.31963495596447e-14 1.35324903493239e-12 1.16653540217006 0.822784810126582 23.2 23 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 4.50776642088362e-11 3.84104887240562e-10 1.16624593929111 0.82258064516129 23.2 23 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.07350940033077e-18 1.48630868632582e-16 1.16603222370758 0.822429906542056 23.2 23 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 4.48516056510081e-10 3.41303929633072e-09 1.16461254161703 0.821428571428571 23.2 23 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 1.19619131000775e-05 4.63809328103823e-05 1.16461254161703 0.821428571428571 23.2 23 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 9.01066218576515e-11 7.24416513578747e-10 1.16212227958934 0.819672131147541 23.2 23 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.12875456535768e-46 4.3274539235771e-44 1.16132902206061 0.819112627986348 23.2 23 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 8.95458327282062e-10 6.43554141273927e-09 1.16000932999009 0.818181818181818 23.2 23 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 8.95458327282062e-10 6.43554141273927e-09 1.16000932999009 0.818181818181818 23.2 23 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 8.95458327282062e-10 6.43554141273927e-09 1.16000932999009 0.818181818181818 23.2 23 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 8.95458327282062e-10 6.43554141273927e-09 1.16000932999009 0.818181818181818 23.2 23 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 8.95458327282062e-10 6.43554141273927e-09 1.16000932999009 0.818181818181818 23.2 23 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000125863519385595 0.00042542467478789 1.16000932999009 0.818181818181818 23.2 23 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000125863519385595 0.00042542467478789 1.16000932999009 0.818181818181818 23.2 23 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00769581241775886 0.0174103991581413 1.16000932999009 0.818181818181818 23.2 23 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00769581241775886 0.0174103991581413 1.16000932999009 0.818181818181818 23.2 23 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00769581241775886 0.0174103991581413 1.16000932999009 0.818181818181818 23.2 23 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00769581241775886 0.0174103991581413 1.16000932999009 0.818181818181818 23.2 23 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00769581241775886 0.0174103991581413 1.16000932999009 0.818181818181818 23.2 23 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00769581241775886 0.0174103991581413 1.16000932999009 0.818181818181818 23.2 23 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00769581241775886 0.0174103991581413 1.16000932999009 0.818181818181818 23.2 23 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 7.51873877297399e-14 1.12622792357284e-12 1.15843750162967 0.817073170731707 23.2 23 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.54416855776161e-66 1.00867037153895e-63 1.15819397892594 0.816901408450704 23.2 23 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.65708458371492e-12 3.72265589287186e-11 1.15819397892594 0.816901408450704 23.2 23 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.75057395782644e-41 1.22545186022078e-38 1.15704634319573 0.816091954022989 23.2 23 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 7.38412373260138e-13 8.40608645719342e-12 1.15661748984392 0.815789473684211 23.2 23 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 7.38412373260138e-13 8.40608645719342e-12 1.15661748984392 0.815789473684211 23.2 23 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 4.53907604442068e-07 2.18213013892251e-06 1.15661748984392 0.815789473684211 23.2 23 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.78093893537262e-09 1.24841187440159e-08 1.15523562904363 0.814814814814815 23.2 23 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.02082107321945e-14 4.94095216918538e-13 1.15401444973174 0.813953488372093 23.2 23 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 7.14658793219385e-11 5.81119693000677e-10 1.15195370964293 0.8125 23.2 23 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 7.14658793219385e-11 5.81119693000677e-10 1.15195370964293 0.8125 23.2 23 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00136150434178356 0.00369032510163431 1.15195370964293 0.8125 23.2 23 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00136150434178356 0.00369032510163431 1.15195370964293 0.8125 23.2 23 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00136150434178356 0.00369032510163431 1.15195370964293 0.8125 23.2 23 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.97486675289786e-14 9.04493126529113e-13 1.15091121759801 0.811764705882353 23.2 23 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.52795759769846e-09 2.42525780749996e-08 1.15028178843881 0.811320754716981 23.2 23 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.89320072846545e-12 3.1189580580351e-11 1.14955879548567 0.810810810810811 23.2 23 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.89320072846545e-12 3.1189580580351e-11 1.14955879548567 0.810810810810811 23.2 23 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 9.01164618303304e-07 4.20445000605115e-06 1.14955879548567 0.810810810810811 23.2 23 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 9.01164618303304e-07 4.20445000605115e-06 1.14955879548567 0.810810810810811 23.2 23 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000251306206224975 0.000810904152966302 1.1477340989849 0.80952380952381 23.2 23 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.50287614906338e-08 2.1578323636871e-07 1.14629763578217 0.808510638297872 23.2 23 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 5.70105560733058e-12 5.63375147863293e-11 1.14588440664165 0.808219178082192 23.2 23 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 9.77002985208253e-16 2.20678610785928e-14 1.1456882271507 0.808080808080808 23.2 23 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 9.77002985208253e-16 2.20678610785928e-14 1.1456882271507 0.808080808080808 23.2 23 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.98038027304942e-16 5.31713420481005e-15 1.14513741550303 0.807692307692308 23.2 23 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.75507744831923e-05 0.000170011939923574 1.14513741550303 0.807692307692308 23.2 23 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.4763500409627e-20 1.49904427523937e-18 1.14513741550303 0.807692307692308 23.2 23 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 5.57092318016128e-11 4.69078324578077e-10 1.14269575790068 0.805970149253731 23.2 23 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.01462037996088e-25 8.02113778157959e-24 1.1425712812386 0.805882352941176 23.2 23 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.11988140384764e-11 1.05535843554649e-10 1.14210795144086 0.805555555555556 23.2 23 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.77881134996996e-06 8.02655251075738e-06 1.14210795144086 0.805555555555556 23.2 23 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 7.88150630900485e-17 2.49230743949198e-15 1.14210795144086 0.805555555555556 23.2 23 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 3.48943729642209e-07 1.71815545771925e-06 1.14114738966504 0.804878048780488 23.2 23 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 3.48943729642209e-07 1.71815545771925e-06 1.14114738966504 0.804878048780488 23.2 23 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.98923587566169e-25 1.41534132553329e-23 1.1409427729554 0.804733727810651 23.2 23 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 6.88937237591819e-08 3.99644352852672e-07 1.14039564566658 0.804347826086957 23.2 23 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.54313304542483e-16 4.48138433395823e-15 1.13953149135059 0.803738317757009 23.2 23 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.91581393447397e-24 1.18530575163324e-22 1.13945020076054 0.803680981595092 23.2 23 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.61721527309485e-19 1.03452703711499e-17 1.13869682261494 0.803149606299213 23.2 23 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.8922957387568e-75 1.34636841812546e-72 1.13746584491212 0.802281368821293 23.2 23 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 2.67333229494904e-08 1.66848765601425e-07 1.1342313448792 0.8 23.2 23 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 9.36911441885167e-05 0.000320486774471777 1.1342313448792 0.8 23.2 23 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 7.05401397319278e-32 9.1253289853212e-30 1.1342313448792 0.8 23.2 23 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.06347339278067e-09 7.6046363714919e-09 1.1342313448792 0.8 23.2 23 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 3.48977225683691e-06 1.51400790288992e-05 1.1342313448792 0.8 23.2 23 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000496958035056548 0.0015046197529478 1.1342313448792 0.8 23.2 23 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00270775274811845 0.00684392923725142 1.1342313448792 0.8 23.2 23 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0154621563409118 0.03134280409276 1.1342313448792 0.8 23.2 23 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0154621563409118 0.03134280409276 1.1342313448792 0.8 23.2 23 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0154621563409118 0.03134280409276 1.1342313448792 0.8 23.2 23 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0154621563409118 0.03134280409276 1.1342313448792 0.8 23.2 23 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0154621563409118 0.03134280409276 1.1342313448792 0.8 23.2 23 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0154621563409118 0.03134280409276 1.1342313448792 0.8 23.2 23 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.31654065501296e-16 6.10451361496933e-15 1.13162989684048 0.798165137614679 23.2 23 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.24568133055736e-11 2.85099045270563e-10 1.12646263703756 0.794520547945205 23.2 23 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.03084382702881e-10 5.98318888265026e-09 1.12522950880873 0.793650793650794 23.2 23 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 6.26962944442138e-11 5.21735830374948e-10 1.1224164350367 0.791666666666667 23.2 23 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.26962944442138e-11 5.21735830374948e-10 1.1224164350367 0.791666666666667 23.2 23 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000182992451219107 0.000601381658394433 1.1224164350367 0.791666666666667 23.2 23 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000182992451219107 0.000601381658394433 1.1224164350367 0.791666666666667 23.2 23 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 9.80686462622628e-25 6.34325834687272e-23 1.12141517149073 0.790960451977401 23.2 23 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 6.57294803845627e-16 1.58530594215649e-14 1.12134235232375 0.790909090909091 23.2 23 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.59412043993337e-14 2.83554173253149e-13 1.12005345306821 0.79 23.2 23 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 7.85703604860099e-14 1.16464190595408e-12 1.11930724823605 0.789473684210526 23.2 23 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00097233358327034 0.0027452989860986 1.11930724823605 0.789473684210526 23.2 23 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00097233358327034 0.0027452989860986 1.11930724823605 0.789473684210526 23.2 23 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.04217398738195e-17 6.75817112568493e-16 1.11809390704555 0.788617886178862 23.2 23 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 3.86855325334225e-08 2.35254328184018e-07 1.11787223894344 0.788461538461538 23.2 23 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 3.86855325334225e-08 2.35254328184018e-07 1.11787223894344 0.788461538461538 23.2 23 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 3.86855325334225e-08 2.35254328184018e-07 1.11787223894344 0.788461538461538 23.2 23 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.94194084152808e-07 9.7646000618179e-07 1.11613190852474 0.787234042553192 23.2 23 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.54536267712012e-25 3.75764337597235e-23 1.11563738840577 0.786885245901639 23.2 23 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 6.78545909243171e-05 0.000239002680409167 1.11397721372064 0.785714285714286 23.2 23 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00531259937924023 0.012495584986213 1.11397721372064 0.785714285714286 23.2 23 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00531259937924023 0.012495584986213 1.11397721372064 0.785714285714286 23.2 23 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00531259937924023 0.012495584986213 1.11397721372064 0.785714285714286 23.2 23 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00531259937924023 0.012495584986213 1.11397721372064 0.785714285714286 23.2 23 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00035402105518924 0.0011120793852854 1.10957414172965 0.782608695652174 23.2 23 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00035402105518924 0.0011120793852854 1.10957414172965 0.782608695652174 23.2 23 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 4.42314284975344e-10 3.3839420834404e-09 1.10957414172965 0.782608695652174 23.2 23 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.70925101547868e-12 2.96558784232782e-11 1.10815706108887 0.781609195402299 23.2 23 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.70925101547868e-12 2.96558784232782e-11 1.10815706108887 0.781609195402299 23.2 23 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.53022940963357e-05 9.40082623997016e-05 1.10764779773359 0.78125 23.2 23 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.7042444600062e-10 1.33985627988333e-09 1.10704086743346 0.780821917808219 23.2 23 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.87368185596311e-06 8.22916444764043e-06 1.1065671657358 0.780487804878049 23.2 23 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.46980018853624e-29 4.54323262020505e-27 1.10625702919832 0.780269058295964 23.2 23 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 8.0055111766772e-21 3.67478787239086e-19 1.10372195743783 0.778481012658228 23.2 23 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 7.09436074294699e-07 3.36509177907119e-06 1.10272491863255 0.777777777777778 23.2 23 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 9.47813543087111e-06 3.7257974359474e-05 1.10272491863255 0.777777777777778 23.2 23 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 9.47813543087111e-06 3.7257974359474e-05 1.10272491863255 0.777777777777778 23.2 23 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 9.47813543087111e-06 3.7257974359474e-05 1.10272491863255 0.777777777777778 23.2 23 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000130192280955913 0.000439013307583565 1.10272491863255 0.777777777777778 23.2 23 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00188011893952132 0.00497287964858519 1.10272491863255 0.777777777777778 23.2 23 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00188011893952132 0.00497287964858519 1.10272491863255 0.777777777777778 23.2 23 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0304871299752422 0.0561958367289762 1.10272491863255 0.777777777777778 23.2 23 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.80050508461189e-16 9.48792760596968e-15 1.10142300019261 0.776859504132231 23.2 23 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.80050508461189e-16 9.48792760596968e-15 1.10142300019261 0.776859504132231 23.2 23 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 9.75429175644645e-12 9.2535714462822e-11 1.10087159944157 0.776470588235294 23.2 23 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 5.60177797949168e-24 3.32138752700694e-22 1.09935524737623 0.775401069518717 23.2 23 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.56387797603362e-06 1.53678738178662e-05 1.09878661535172 0.775 23.2 23 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 4.82416805089334e-05 0.000172049903168452 1.09764323697987 0.774193548387097 23.2 23 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.08884677221412e-12 6.909197915658e-11 1.09556436721286 0.772727272727273 23.2 23 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000677811341478869 0.00201783585549044 1.09556436721286 0.772727272727273 23.2 23 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 6.58734183331338e-15 1.26672803091959e-13 1.0944337538308 0.771929824561403 23.2 23 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 5.08414545039935e-07 2.43593904913073e-06 1.09287916043048 0.770833333333333 23.2 23 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.33217103122891e-11 1.23942855746231e-10 1.09186063371992 0.770114942528736 23.2 23 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000247492376539598 0.000800412845036019 1.09060706238384 0.769230769230769 23.2 23 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000247492376539598 0.000800412845036019 1.09060706238384 0.769230769230769 23.2 23 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0102624900629837 0.0223295464214462 1.09060706238384 0.769230769230769 23.2 23 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0102624900629837 0.0223295464214462 1.09060706238384 0.769230769230769 23.2 23 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0102624900629837 0.0223295464214462 1.09060706238384 0.769230769230769 23.2 23 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0102624900629837 0.0223295464214462 1.09060706238384 0.769230769230769 23.2 23 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 7.31977825595945e-08 4.21696638248028e-07 1.08865954977244 0.767857142857143 23.2 23 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 9.12116676323568e-05 0.000312757115761069 1.08697170550923 0.766666666666667 23.2 23 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.06107865135835e-08 6.92621523340797e-08 1.08549484177892 0.765625 23.2 23 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.61083063068e-07 1.77179723705436e-06 1.08419172672276 0.764705882352941 23.2 23 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 3.38540999112047e-05 0.000123841604559497 1.08419172672276 0.764705882352941 23.2 23 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00358788825217741 0.00892581290707773 1.08419172672276 0.764705882352941 23.2 23 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00358788825217741 0.00892581290707773 1.08419172672276 0.764705882352941 23.2 23 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00358788825217741 0.00892581290707773 1.08419172672276 0.764705882352941 23.2 23 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00358788825217741 0.00892581290707773 1.08419172672276 0.764705882352941 23.2 23 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00358788825217741 0.00892581290707773 1.08419172672276 0.764705882352941 23.2 23 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00358788825217741 0.00892581290707773 1.08419172672276 0.764705882352941 23.2 23 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00358788825217741 0.00892581290707773 1.08419172672276 0.764705882352941 23.2 23 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.5462049904244e-09 1.08923252543264e-08 1.0830334022284 0.763888888888889 23.2 23 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 1.26352993775261e-05 4.87263713122485e-05 1.08199700662818 0.763157894736842 23.2 23 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.26352993775261e-05 4.87263713122485e-05 1.08199700662818 0.763157894736842 23.2 23 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 5.44898350582737e-17 1.76225080199826e-15 1.08119174961506 0.762589928057554 23.2 23 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 4.7369837268732e-06 2.00616900099422e-05 1.08022032845638 0.761904761904762 23.2 23 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 7.5341886288157e-09 5.03340395249049e-08 1.07921266023953 0.761194029850746 23.2 23 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.78242487238182e-06 8.02655251075738e-06 1.07875263779271 0.760869565217391 23.2 23 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.78242487238182e-06 8.02655251075738e-06 1.07875263779271 0.760869565217391 23.2 23 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.78242487238182e-06 8.02655251075738e-06 1.07875263779271 0.760869565217391 23.2 23 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.78242487238182e-06 8.02655251075738e-06 1.07875263779271 0.760869565217391 23.2 23 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.000465779923482645 0.00141322991709127 1.07751977763524 0.76 23.2 23 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000465779923482645 0.00141322991709127 1.07751977763524 0.76 23.2 23 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000465779923482645 0.00141322991709127 1.07751977763524 0.76 23.2 23 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 7.20632548150697e-13 8.33707411397107e-12 1.07697447410404 0.759615384615385 23.2 23 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000170917021576036 0.000564303762651273 1.07556420635096 0.758620689655172 23.2 23 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000170917021576036 0.000564303762651273 1.07556420635096 0.758620689655172 23.2 23 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 8.97152705765211e-16 2.09286606607196e-14 1.07408271295378 0.757575757575758 23.2 23 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 8.80348594825215e-06 3.4895154608253e-05 1.07198694180656 0.75609756097561 23.2 23 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.11677305912175e-14 2.06385462744189e-13 1.07198694180656 0.75609756097561 23.2 23 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.13514901249955e-10 9.07481485835317e-10 1.07158484617947 0.755813953488372 23.2 23 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.24608501420487e-06 5.73844328548066e-06 1.07057550409516 0.755102040816326 23.2 23 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 4.9314229228249e-29 4.67827654611989e-27 1.06879492113617 0.753846153846154 23.2 23 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.57484729170461e-08 1.61410030665007e-07 1.06879492113617 0.753846153846154 23.2 23 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 9.80603212875748e-09 6.43040724388106e-08 1.06847880314707 0.753623188405797 23.2 23 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 5.57243870935538e-15 1.10133059491843e-13 1.06608953927599 0.751937984496124 23.2 23 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 8.6616456726477e-07 4.06782897431606e-06 1.06334188582425 0.75 23.2 23 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.000867106867099635 0.00248229645172346 1.06334188582425 0.75 23.2 23 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000867106867099635 0.00248229645172346 1.06334188582425 0.75 23.2 23 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0194708627836767 0.0387511017359047 1.06334188582425 0.75 23.2 23 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0194708627836767 0.0387511017359047 1.06334188582425 0.75 23.2 23 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0194708627836767 0.0387511017359047 1.06334188582425 0.75 23.2 23 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0194708627836767 0.0387511017359047 1.06334188582425 0.75 23.2 23 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0194708627836767 0.0387511017359047 1.06334188582425 0.75 23.2 23 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 6.09364076490358e-06 2.47044182577145e-05 1.06334188582425 0.75 23.2 23 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 6.09364076490358e-06 2.47044182577145e-05 1.06334188582425 0.75 23.2 23 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000117059839746727 0.000397556448590912 1.06334188582425 0.75 23.2 23 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0003172053510507 0.00101434430234864 1.06334188582425 0.75 23.2 23 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0003172053510507 0.00101434430234864 1.06334188582425 0.75 23.2 23 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00239846022791171 0.00610556154618671 1.06334188582425 0.75 23.2 23 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00239846022791171 0.00610556154618671 1.06334188582425 0.75 23.2 23 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00239846022791171 0.00610556154618671 1.06334188582425 0.75 23.2 23 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00674649796712308 0.0154843009793809 1.06334188582425 0.75 23.2 23 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00674649796712308 0.0154843009793809 1.06334188582425 0.75 23.2 23 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00674649796712308 0.0154843009793809 1.06334188582425 0.75 23.2 23 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00674649796712308 0.0154843009793809 1.06334188582425 0.75 23.2 23 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00674649796712308 0.0154843009793809 1.06334188582425 0.75 23.2 23 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0587462218006189 0.101328331663371 1.06334188582425 0.75 23.2 23 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0587462218006189 0.101328331663371 1.06334188582425 0.75 23.2 23 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0587462218006189 0.101328331663371 1.06334188582425 0.75 23.2 23 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0587462218006189 0.101328331663371 1.06334188582425 0.75 23.2 23 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0587462218006189 0.101328331663371 1.06334188582425 0.75 23.2 23 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0587462218006189 0.101328331663371 1.06334188582425 0.75 23.2 23 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0587462218006189 0.101328331663371 1.06334188582425 0.75 23.2 23 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 8.51301301372538e-13 9.53859647128442e-12 1.0601486669479 0.747747747747748 23.2 23 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 6.7291493862333e-23 3.5465109543e-21 1.05996619729782 0.747619047619048 23.2 23 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.92245904340736e-11 3.38282376895071e-10 1.05961086166346 0.747368421052632 23.2 23 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.92245904340736e-11 3.38282376895071e-10 1.05961086166346 0.747368421052632 23.2 23 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.19581500244885e-55 5.20774124747452e-53 1.05670429602509 0.745318352059925 23.2 23 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.3965189687615e-16 4.22818402669704e-15 1.05401432542228 0.743421052631579 23.2 23 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 7.97087963990337e-05 0.000278003963911336 1.05321482024497 0.742857142857143 23.2 23 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 7.97087963990337e-05 0.000278003963911336 1.05321482024497 0.742857142857143 23.2 23 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.11160610065577e-13 1.56615394181501e-12 1.05190810210571 0.741935483870968 23.2 23 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.11160610065577e-13 1.56615394181501e-12 1.05190810210571 0.741935483870968 23.2 23 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.11160610065577e-13 1.56615394181501e-12 1.05190810210571 0.741935483870968 23.2 23 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000582635506778696 0.00174178639946656 1.05021420822148 0.740740740740741 23.2 23 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000582635506778696 0.00174178639946656 1.05021420822148 0.740740740740741 23.2 23 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000582635506778696 0.00174178639946656 1.05021420822148 0.740740740740741 23.2 23 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00159521715263283 0.00430738900986055 1.04793113385578 0.739130434782609 23.2 23 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 8.93283972355147e-28 7.94464432913359e-26 1.04770450515036 0.738970588235294 23.2 23 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 5.02676253893798e-19 1.88855484724716e-17 1.04591005163041 0.737704918032787 23.2 23 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00442191793702404 0.0107746390828514 1.04468676502031 0.736842105263158 23.2 23 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.51982614730623e-16 4.48138433395823e-15 1.04327883137473 0.735849056603774 23.2 23 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000144807667237531 0.000483711996429593 1.04249204492573 0.735294117647059 23.2 23 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.000144807667237531 0.000483711996429593 1.04249204492573 0.735294117647059 23.2 23 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000144807667237531 0.000483711996429593 1.04249204492573 0.735294117647059 23.2 23 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.773080973933e-14 3.11493114309464e-13 1.04039206095034 0.733812949640288 23.2 23 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.37581435370092e-05 5.29130763599028e-05 1.03971206613926 0.733333333333333 23.2 23 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000390106744921151 0.00122004812752263 1.03971206613926 0.733333333333333 23.2 23 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0124759276148251 0.0257666835934633 1.03971206613926 0.733333333333333 23.2 23 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0124759276148251 0.0257666835934633 1.03971206613926 0.733333333333333 23.2 23 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0124759276148251 0.0257666835934633 1.03971206613926 0.733333333333333 23.2 23 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0124759276148251 0.0257666835934633 1.03971206613926 0.733333333333333 23.2 23 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0124759276148251 0.0257666835934633 1.03971206613926 0.733333333333333 23.2 23 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0124759276148251 0.0257666835934633 1.03971206613926 0.733333333333333 23.2 23 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0124759276148251 0.0257666835934633 1.03971206613926 0.733333333333333 23.2 23 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0124759276148251 0.0257666835934633 1.03971206613926 0.733333333333333 23.2 23 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.86183307636838e-16 1.19282559787452e-14 1.03850799889417 0.732484076433121 23.2 23 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 7.80601576876666e-12 7.55643567275847e-11 1.03802422187605 0.732142857142857 23.2 23 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.76993224930502e-83 2.51861359076104e-80 1.03607670926465 0.730769230769231 23.2 23 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.33086086252606e-08 8.56929867590312e-08 1.03607670926465 0.730769230769231 23.2 23 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00105827469375663 0.00290719090582177 1.03607670926465 0.730769230769231 23.2 23 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00105827469375663 0.00290719090582177 1.03607670926465 0.730769230769231 23.2 23 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.54106058937638e-15 3.27302868460087e-14 1.03361404815604 0.729032258064516 23.2 23 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.87373382347476e-14 5.92722928043504e-13 1.03296068908641 0.728571428571429 23.2 23 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00289699734288745 0.00730926811866817 1.03111940443563 0.727272727272727 23.2 23 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.036172406802653 0.0659914549745837 1.03111940443563 0.727272727272727 23.2 23 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.036172406802653 0.0659914549745837 1.03111940443563 0.727272727272727 23.2 23 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.036172406802653 0.0659914549745837 1.03111940443563 0.727272727272727 23.2 23 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.036172406802653 0.0659914549745837 1.03111940443563 0.727272727272727 23.2 23 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.036172406802653 0.0659914549745837 1.03111940443563 0.727272727272727 23.2 23 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.036172406802653 0.0659914549745837 1.03111940443563 0.727272727272727 23.2 23 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.036172406802653 0.0659914549745837 1.03111940443563 0.727272727272727 23.2 23 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 2.39507683305312e-06 1.04867517951834e-05 1.03111940443563 0.727272727272727 23.2 23 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000260621647469928 0.000837166149773607 1.03111940443563 0.727272727272727 23.2 23 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000260621647469928 0.000837166149773607 1.03111940443563 0.727272727272727 23.2 23 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 6.53526115328605e-05 0.000230761206479554 1.02789715629677 0.725 23.2 23 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000701212215921699 0.00208314192746676 1.0266749242441 0.724137931034483 23.2 23 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 4.19871102201168e-07 2.02534433366868e-06 1.02517063864081 0.723076923076923 23.2 23 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.0920380764324e-07 5.67142402468358e-07 1.02395885301594 0.722222222222222 23.2 23 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00802808846508327 0.0179340186590479 1.02395885301594 0.722222222222222 23.2 23 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00802808846508327 0.0179340186590479 1.02395885301594 0.722222222222222 23.2 23 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00802808846508327 0.0179340186590479 1.02395885301594 0.722222222222222 23.2 23 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00802808846508327 0.0179340186590479 1.02395885301594 0.722222222222222 23.2 23 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00802808846508327 0.0179340186590479 1.02395885301594 0.722222222222222 23.2 23 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00802808846508327 0.0179340186590479 1.02395885301594 0.722222222222222 23.2 23 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00802808846508327 0.0179340186590479 1.02395885301594 0.722222222222222 23.2 23 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00802808846508327 0.0179340186590479 1.02395885301594 0.722222222222222 23.2 23 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.46219524364503e-13 2.0201008074824e-12 1.02283362350713 0.721428571428571 23.2 23 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 4.38005196874315e-05 0.000157394291705088 1.02212708404811 0.720930232558139 23.2 23 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.84261960983877e-07 1.41931498414055e-06 1.02164220402722 0.720588235294118 23.2 23 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00189909043640049 0.00500445498332944 1.02080821039128 0.72 23.2 23 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00189909043640049 0.00500445498332944 1.02080821039128 0.72 23.2 23 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.5264105704608e-19 1.02716635479021e-17 1.01945793498071 0.719047619047619 23.2 23 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 2.93271460789752e-05 0.000108678460599952 1.01710962991884 0.717391304347826 23.2 23 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00124621089609869 0.00339723774932649 1.01270655792785 0.714285714285714 23.2 23 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00518700107939704 0.0122813686122828 1.01270655792785 0.714285714285714 23.2 23 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00518700107939704 0.0122813686122828 1.01270655792785 0.714285714285714 23.2 23 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0226372167723424 0.0439464658486265 1.01270655792785 0.714285714285714 23.2 23 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0226372167723424 0.0439464658486265 1.01270655792785 0.714285714285714 23.2 23 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0226372167723424 0.0439464658486265 1.01270655792785 0.714285714285714 23.2 23 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0226372167723424 0.0439464658486265 1.01270655792785 0.714285714285714 23.2 23 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.1099957953613 0.169765744901442 1.01270655792785 0.714285714285714 23.2 23 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.37406162486852e-06 1.46828430953758e-05 1.00927365434166 0.711864406779661 23.2 23 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.52664201956758e-07 7.75861283515953e-07 1.00737652341244 0.710526315789474 23.2 23 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000818755635454149 0.00242222301299637 1.00617296723154 0.709677419354839 23.2 23 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.55250076153564e-11 1.40262852147461e-10 1.00473249054259 0.708661417322835 23.2 23 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.80986381181823e-08 1.14463831298548e-07 1.00360357763187 0.707865168539326 23.2 23 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 6.90882015472644e-08 3.99644352852672e-07 1.00282649394807 0.707317073170732 23.2 23 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000134989116953687 0.000454112324882026 1.00282649394807 0.707317073170732 23.2 23 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 7.63049684140459e-16 1.80969950088645e-14 1.00169887795038 0.706521739130435 23.2 23 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.21848331653908e-08 7.9173596321238e-08 1.00169887795038 0.706521739130435 23.2 23 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 4.64496941354862e-08 2.76560312781577e-07 1.0007923631287 0.705882352941177 23.2 23 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 4.64496941354862e-08 2.76560312781577e-07 1.0007923631287 0.705882352941177 23.2 23 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 4.64496941354862e-08 2.76560312781577e-07 1.0007923631287 0.705882352941177 23.2 23 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 4.64496941354862e-08 2.76560312781577e-07 1.0007923631287 0.705882352941177 23.2 23 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 4.64496941354862e-08 2.76560312781577e-07 1.0007923631287 0.705882352941177 23.2 23 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000538575200027681 0.00162028014722915 1.0007923631287 0.705882352941177 23.2 23 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000538575200027681 0.00162028014722915 1.0007923631287 0.705882352941177 23.2 23 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0143271612829927 0.0293346050441706 1.0007923631287 0.705882352941177 23.2 23 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0143271612829927 0.0293346050441706 1.0007923631287 0.705882352941177 23.2 23 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0143271612829927 0.0293346050441706 1.0007923631287 0.705882352941177 23.2 23 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.5350438520727e-13 2.10035327067255e-12 0.999723140518522 0.705128205128205 23.2 23 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.83221056926216e-11 5.61978938731795e-10 0.999425160446833 0.704918032786885 23.2 23 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00218791776282921 0.00567105095902726 0.997703497810404 0.703703703703704 23.2 23 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.19123255819364e-07 6.11958097584676e-07 0.997703497810404 0.703703703703704 23.2 23 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00914331925828617 0.0200476784353486 0.992452426769297 0.7 23.2 23 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00914331925828617 0.0200476784353486 0.992452426769297 0.7 23.2 23 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00914331925828617 0.0200476784353486 0.992452426769297 0.7 23.2 23 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00914331925828617 0.0200476784353486 0.992452426769297 0.7 23.2 23 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00914331925828617 0.0200476784353486 0.992452426769297 0.7 23.2 23 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0655454017886795 0.110980067645009 0.992452426769297 0.7 23.2 23 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.36854370885555e-07 7.00517157446563e-07 0.990744247033033 0.698795180722892 23.2 23 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 9.16297966792184e-08 5.15372334681928e-07 0.989155242627206 0.697674418604651 23.2 23 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000154349151308883 0.000511978653409184 0.989155242627206 0.697674418604651 23.2 23 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000933103361471558 0.00264503203859368 0.988156095917481 0.696969696969697 23.2 23 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000933103361471558 0.00264503203859368 0.988156095917481 0.696969696969697 23.2 23 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.48926991076591e-07 1.71815545771925e-06 0.987068417220819 0.69620253164557 23.2 23 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000101972852632388 0.000347146816497339 0.98628812598191 0.695652173913043 23.2 23 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00587249492061235 0.0137217738457001 0.98628812598191 0.695652173913043 23.2 23 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.55872073893384e-07 7.86545961525835e-07 0.984112490409891 0.694117647058824 23.2 23 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.55872073893384e-07 7.86545961525835e-07 0.984112490409891 0.694117647058824 23.2 23 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 6.75907257396763e-13 7.88373792848848e-12 0.983591244387428 0.69375 23.2 23 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.61535220138617e-10 2.04486053987501e-09 0.983305399794464 0.693548387096774 23.2 23 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.04192927072303e-07 5.67142402468358e-07 0.982785682352712 0.693181818181818 23.2 23 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 4.46271870820899e-05 0.000159960924981899 0.981546356145458 0.692307692307692 23.2 23 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00379092585734916 0.00926887885740182 0.981546356145458 0.692307692307692 23.2 23 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00379092585734916 0.00926887885740182 0.981546356145458 0.692307692307692 23.2 23 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.040189701405236 0.0728534332479628 0.981546356145458 0.692307692307692 23.2 23 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.040189701405236 0.0728534332479628 0.981546356145458 0.692307692307692 23.2 23 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.040189701405236 0.0728534332479628 0.981546356145458 0.692307692307692 23.2 23 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.040189701405236 0.0728534332479628 0.981546356145458 0.692307692307692 23.2 23 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 3.95388505132129e-07 1.93346337732996e-06 0.980199927673379 0.691358024691358 23.2 23 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 6.22847778605189e-09 4.2005326490767e-08 0.975543014517657 0.688073394495413 23.2 23 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00159832926635169 0.00430761845836829 0.974730062005559 0.6875 23.2 23 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0250806728397698 0.0483601591476861 0.974730062005559 0.6875 23.2 23 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0250806728397698 0.0483601591476861 0.974730062005559 0.6875 23.2 23 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0250806728397698 0.0483601591476861 0.974730062005559 0.6875 23.2 23 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0250806728397698 0.0483601591476861 0.974730062005559 0.6875 23.2 23 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0250806728397698 0.0483601591476861 0.974730062005559 0.6875 23.2 23 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.24750168349164e-09 8.83181540103779e-09 0.972533074638154 0.685950413223141 23.2 23 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.015841457942545 0.0320204469492067 0.970066281804576 0.684210526315789 23.2 23 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.015841457942545 0.0320204469492067 0.970066281804576 0.684210526315789 23.2 23 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.75628928625236e-23 2.05584602089889e-21 0.969837384616797 0.684049079754601 23.2 23 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.78389734188607e-68 8.46161972501294e-66 0.969319330020634 0.683683683683684 23.2 23 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0100941519433462 0.022098428023664 0.966674441658406 0.681818181818182 23.2 23 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 6.51896311069867e-08 3.80183791250992e-07 0.964096643147317 0.68 23.2 23 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00270470060847416 0.00684392923725142 0.960437832357384 0.67741935483871 23.2 23 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00270470060847416 0.00684392923725142 0.960437832357384 0.67741935483871 23.2 23 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.29220602330874e-12 7.9728440345732e-11 0.959601214036515 0.676829268292683 23.2 23 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 3.76666825854187e-10 2.91302659342667e-09 0.955248029818472 0.673758865248227 23.2 23 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.42739630233334e-15 8.87349991298639e-14 0.953669852757172 0.672645739910314 23.2 23 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 1.16197018421058e-05 4.51771467795536e-05 0.951944164452182 0.671428571428571 23.2 23 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 1.16197018421058e-05 4.51771467795536e-05 0.951944164452182 0.671428571428571 23.2 23 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.47755502376672e-23 8.41024319528016e-22 0.947720040841574 0.668449197860963 23.2 23 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 9.3686559084832e-18 3.17418984708848e-16 0.946898911564311 0.667870036101083 23.2 23 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0108905147839816 0.023269072879288 0.94519278739933 0.666666666666667 23.2 23 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0108905147839816 0.023269072879288 0.94519278739933 0.666666666666667 23.2 23 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0108905147839816 0.023269072879288 0.94519278739933 0.666666666666667 23.2 23 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0695754948406059 0.115181762986521 0.94519278739933 0.666666666666667 23.2 23 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0695754948406059 0.115181762986521 0.94519278739933 0.666666666666667 23.2 23 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0695754948406059 0.115181762986521 0.94519278739933 0.666666666666667 23.2 23 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0695754948406059 0.115181762986521 0.94519278739933 0.666666666666667 23.2 23 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0695754948406059 0.115181762986521 0.94519278739933 0.666666666666667 23.2 23 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0695754948406059 0.115181762986521 0.94519278739933 0.666666666666667 23.2 23 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0170559556160644 0.0344264182151201 0.94519278739933 0.666666666666667 23.2 23 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00190511527297198 0.00501105181781724 0.94519278739933 0.666666666666667 23.2 23 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00451770725963003 0.0109892263768436 0.94519278739933 0.666666666666667 23.2 23 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00699694204638911 0.0160074735241346 0.94519278739933 0.666666666666667 23.2 23 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00699694204638911 0.0160074735241346 0.94519278739933 0.666666666666667 23.2 23 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.115264405451372 0.175799838110721 0.94519278739933 0.666666666666667 23.2 23 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.115264405451372 0.175799838110721 0.94519278739933 0.666666666666667 23.2 23 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.115264405451372 0.175799838110721 0.94519278739933 0.666666666666667 23.2 23 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.115264405451372 0.175799838110721 0.94519278739933 0.666666666666667 23.2 23 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.115264405451372 0.175799838110721 0.94519278739933 0.666666666666667 23.2 23 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.115264405451372 0.175799838110721 0.94519278739933 0.666666666666667 23.2 23 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.19559767709358e-09 8.50667747252083e-09 0.941887917513318 0.664335664335664 23.2 23 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.08135502808698e-15 2.3314669772239e-14 0.939566639855286 0.662698412698413 23.2 23 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.08135502808698e-15 2.3314669772239e-14 0.939566639855286 0.662698412698413 23.2 23 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.08135502808698e-15 2.3314669772239e-14 0.939566639855286 0.662698412698413 23.2 23 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 4.63810289770773e-45 8.25002552929762e-43 0.936721149099976 0.660691421254802 23.2 23 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000376024625304073 0.001178597008387 0.935740859525337 0.66 23.2 23 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000872205359003323 0.00248229645172346 0.934451960269792 0.659090909090909 23.2 23 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.68437030617318e-08 1.0700263150377e-07 0.930762363164226 0.656488549618321 23.2 23 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.68437030617318e-08 1.0700263150377e-07 0.930762363164226 0.656488549618321 23.2 23 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 9.26367152380435e-12 8.84711716669368e-11 0.930424150096216 0.65625 23.2 23 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.88072948020302e-27 1.57428120607582e-25 0.927902675434708 0.654471544715447 23.2 23 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 1.0403719792924e-05 4.06716847948648e-05 0.927689217262305 0.654320987654321 23.2 23 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0115458521293683 0.0245954305091183 0.927016003026266 0.653846153846154 23.2 23 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.018009758860972 0.0362487791501601 0.92464511810804 0.652173913043478 23.2 23 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 8.10116905012015e-05 0.000281857299714449 0.923711133140254 0.651515151515151 23.2 23 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00141379399979666 0.00382476969906968 0.923211559785392 0.651162790697674 23.2 23 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00215962243851582 0.00560792468979563 0.921562967714347 0.65 23.2 23 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0282808583561684 0.0543833262713888 0.921562967714347 0.65 23.2 23 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00330634181144624 0.00832729981891681 0.919647036388537 0.648648648648649 23.2 23 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00507516560075117 0.0120566955757411 0.917392999534644 0.647058823529412 23.2 23 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00507516560075117 0.0120566955757411 0.917392999534644 0.647058823529412 23.2 23 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0447954440271944 0.0805864941222473 0.917392999534644 0.647058823529412 23.2 23 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0447954440271944 0.0805864941222473 0.917392999534644 0.647058823529412 23.2 23 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.68323609668309e-11 5.52921218929072e-10 0.915655512793101 0.645833333333333 23.2 23 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000978011503549244 0.00275586211792193 0.915655512793101 0.645833333333333 23.2 23 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 1.14725622436131e-06 5.33511636361485e-06 0.914275266316174 0.644859813084112 23.2 23 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00226701834879351 0.00580209911930426 0.911435902135068 0.642857142857143 23.2 23 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0717841737444443 0.116210329053862 0.911435902135068 0.642857142857143 23.2 23 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0717841737444443 0.116210329053862 0.911435902135068 0.642857142857143 23.2 23 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0717841737444443 0.116210329053862 0.911435902135068 0.642857142857143 23.2 23 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0717841737444443 0.116210329053862 0.911435902135068 0.642857142857143 23.2 23 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 4.04523028212137e-06 1.72346188367027e-05 0.907385075903357 0.64 23.2 23 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0187397438878634 0.0376647677294204 0.907385075903357 0.64 23.2 23 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.66215700555786e-12 2.95956985852252e-11 0.90665488405043 0.639484978540773 23.2 23 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 9.4481467951258e-05 0.000322415177205372 0.905809754591025 0.638888888888889 23.2 23 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.31737388040326e-08 8.52101378097201e-08 0.903050433821016 0.636942675159236 23.2 23 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.008121009336251 0.0180848142182867 0.902229478881179 0.636363636363636 23.2 23 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.008121009336251 0.0180848142182867 0.902229478881179 0.636363636363636 23.2 23 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.116948143014226 0.176663702239111 0.902229478881179 0.636363636363636 23.2 23 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.116948143014226 0.176663702239111 0.902229478881179 0.636363636363636 23.2 23 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.116948143014226 0.176663702239111 0.902229478881179 0.636363636363636 23.2 23 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.03180776182861e-29 1.12943265006316e-27 0.897418657398586 0.632970451010886 23.2 23 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00161295083363559 0.00433880725191576 0.896968665593242 0.63265306122449 23.2 23 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0459261908781255 0.0825163757822886 0.895445798588839 0.631578947368421 23.2 23 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0192789992704328 0.0386394591011632 0.892682076988256 0.62962962962963 23.2 23 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000501935115539291 0.00151646214312614 0.891835130046142 0.629032258064516 23.2 23 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.87833614670646e-68 1.02396808419082e-65 0.891495585791105 0.628792769528728 23.2 23 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.41567971458498e-25 1.06026959676549e-23 0.891394598974675 0.628721541155867 23.2 23 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 4.92759830136795e-06 2.00916114121679e-05 0.889340486325733 0.627272727272727 23.2 23 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 7.76013248854886e-08 4.42974941487229e-07 0.887261616558726 0.625806451612903 23.2 23 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 9.71233995405885e-20 4.0648999278311e-18 0.88691296306417 0.625560538116592 23.2 23 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0727583321667219 0.117312326133226 0.886118238186872 0.625 23.2 23 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.195411751295768 0.275045422446961 0.886118238186872 0.625 23.2 23 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.195411751295768 0.275045422446961 0.886118238186872 0.625 23.2 23 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.195411751295768 0.275045422446961 0.886118238186872 0.625 23.2 23 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.195411751295768 0.275045422446961 0.886118238186872 0.625 23.2 23 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00116419848004377 0.00317975899635757 0.880007077923514 0.620689655172414 23.2 23 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00116419848004377 0.00317975899635757 0.880007077923514 0.620689655172414 23.2 23 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00116419848004377 0.00317975899635757 0.880007077923514 0.620689655172414 23.2 23 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0196564726036405 0.0390658666410341 0.880007077923514 0.620689655172414 23.2 23 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.116592764337198 0.176663702239111 0.872485649907074 0.615384615384615 23.2 23 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.116592764337198 0.176663702239111 0.872485649907074 0.615384615384615 23.2 23 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.116592764337198 0.176663702239111 0.872485649907074 0.615384615384615 23.2 23 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.116592764337198 0.176663702239111 0.872485649907074 0.615384615384615 23.2 23 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.116592764337198 0.176663702239111 0.872485649907074 0.615384615384615 23.2 23 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.116592764337198 0.176663702239111 0.872485649907074 0.615384615384615 23.2 23 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00870760040619917 0.019330601213762 0.872485649907074 0.615384615384615 23.2 23 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00393741465046004 0.009610533529339 0.868034192509589 0.612244897959184 23.2 23 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0728770880546532 0.117312326133226 0.866426721782719 0.611111111111111 23.2 23 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0728770880546532 0.117312326133226 0.866426721782719 0.611111111111111 23.2 23 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00881056247912358 0.0195287078003004 0.864505598231095 0.609756097560976 23.2 23 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.96288142237029e-05 0.00014312640264043 0.864176262765102 0.60952380952381 23.2 23 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0467069947714204 0.0834778126876956 0.863002110234171 0.608695652173913 23.2 23 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0467069947714204 0.0834778126876956 0.863002110234171 0.608695652173913 23.2 23 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00182540775866243 0.00484618515032956 0.859970486896112 0.60655737704918 23.2 23 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0200224301475711 0.0396271461752347 0.859266170363027 0.606060606060606 23.2 23 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0200224301475711 0.0396271461752347 0.859266170363027 0.606060606060606 23.2 23 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000393909890696868 0.00122924073346852 0.857674936714207 0.604938271604938 23.2 23 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0059573765463803 0.0138067537874579 0.856580963580643 0.604166666666667 23.2 23 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0059573765463803 0.0138067537874579 0.856580963580643 0.604166666666667 23.2 23 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0059573765463803 0.0138067537874579 0.856580963580643 0.604166666666667 23.2 23 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0059573765463803 0.0138067537874579 0.856580963580643 0.604166666666667 23.2 23 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0465782983080951 0.0834772273204273 0.850673508659397 0.6 23.2 23 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0304040840469243 0.0561958367289762 0.850673508659397 0.6 23.2 23 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0304040840469243 0.0561958367289762 0.850673508659397 0.6 23.2 23 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0723941896610612 0.116931818260715 0.850673508659397 0.6 23.2 23 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.115020741730046 0.175799838110721 0.850673508659397 0.6 23.2 23 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.189842910945412 0.272325062777541 0.850673508659397 0.6 23.2 23 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.189842910945412 0.272325062777541 0.850673508659397 0.6 23.2 23 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.189842910945412 0.272325062777541 0.850673508659397 0.6 23.2 23 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.189842910945412 0.272325062777541 0.850673508659397 0.6 23.2 23 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0133108971096203 0.0273719748366903 0.843922131606545 0.595238095238095 23.2 23 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0462077473283982 0.0829175592034183 0.840171366577182 0.592592592592593 23.2 23 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00888632129546466 0.0196659956507717 0.839099719425936 0.591836734693878 23.2 23 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0714845222479161 0.116210329053862 0.837784516103952 0.590909090909091 23.2 23 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0198755396379042 0.039446154678853 0.836132081160946 0.58974358974359 23.2 23 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.000588866684556699 0.00175672388285992 0.834920295536075 0.588888888888889 23.2 23 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.11270531522319 0.173383420067674 0.833993635940585 0.588235294117647 23.2 23 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.11270531522319 0.173383420067674 0.833993635940585 0.588235294117647 23.2 23 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.11270531522319 0.173383420067674 0.833993635940585 0.588235294117647 23.2 23 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0131645952305976 0.0271103024792191 0.832180606297236 0.58695652173913 23.2 23 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0130430676354313 0.0268989641235055 0.827043688974414 0.583333333333333 23.2 23 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0702715555330703 0.115181762986521 0.827043688974414 0.583333333333333 23.2 23 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.183269850457293 0.263960523482519 0.827043688974414 0.583333333333333 23.2 23 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.002642323706048 0.00671433327447553 0.820825315373102 0.578947368421053 23.2 23 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0292205540086984 0.0548504870984959 0.820825315373102 0.578947368421053 23.2 23 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0192058141170563 0.0385470712109607 0.819167082412753 0.577777777777778 23.2 23 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0688441995898759 0.115181762986521 0.817955296787882 0.576923076923077 23.2 23 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0441446361882145 0.0796170054446504 0.816302861844876 0.575757575757576 23.2 23 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00552407129968673 0.0129501704439114 0.810165246342283 0.571428571428571 23.2 23 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.043255585647615 0.0781125613915687 0.810165246342283 0.571428571428571 23.2 23 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.106891342130693 0.166783311241201 0.810165246342283 0.571428571428571 23.2 23 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0672675213059761 0.113683708810456 0.810165246342283 0.571428571428571 23.2 23 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.176337551794202 0.254233370013323 0.810165246342283 0.571428571428571 23.2 23 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.176337551794202 0.254233370013323 0.810165246342283 0.571428571428571 23.2 23 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.176337551794202 0.254233370013323 0.810165246342283 0.571428571428571 23.2 23 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.176337551794202 0.254233370013323 0.810165246342283 0.571428571428571 23.2 23 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0423063826523593 0.0764955305137323 0.80469115683997 0.567567567567568 23.2 23 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0655897659096644 0.110980067645009 0.80341386928943 0.566666666666667 23.2 23 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.103695307967361 0.1619741199095 0.801359102360302 0.565217391304348 23.2 23 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.017507122991407 0.035287019853785 0.799117538437615 0.563636363636364 23.2 23 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.5109526727682e-05 5.79537911953949e-05 0.798855833005018 0.563451776649746 23.2 23 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0114219563033002 0.0243679817385251 0.797506414368185 0.5625 23.2 23 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0638470799012105 0.10972752983022 0.797506414368185 0.5625 23.2 23 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.16935812545432 0.247878238382925 0.797506414368185 0.5625 23.2 23 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0402924307803657 0.0729467290082193 0.795345150372607 0.560975609756098 23.2 23 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0602695447628291 0.103829978447344 0.787660656166108 0.555555555555556 23.2 23 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0971397649167226 0.153070069027088 0.787660656166108 0.555555555555556 23.2 23 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.295595933601262 0.399841267599426 0.787660656166108 0.555555555555556 23.2 23 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.295595933601262 0.399841267599426 0.787660656166108 0.555555555555556 23.2 23 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.295595933601262 0.399841267599426 0.787660656166108 0.555555555555556 23.2 23 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.295595933601262 0.399841267599426 0.787660656166108 0.555555555555556 23.2 23 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.295595933601262 0.399841267599426 0.787660656166108 0.555555555555556 23.2 23 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.155817260797323 0.233152431245626 0.779784049604447 0.55 23.2 23 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0059103727805051 0.0137876401092766 0.777497292860739 0.548387096774194 23.2 23 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0340326814852086 0.0626500721260696 0.775771438714544 0.547169811320755 23.2 23 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.149379525990025 0.223754805772426 0.773339553326725 0.545454545454545 23.2 23 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.277316632462835 0.377628294731689 0.773339553326725 0.545454545454545 23.2 23 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.277316632462835 0.377628294731689 0.773339553326725 0.545454545454545 23.2 23 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.277316632462835 0.377628294731689 0.773339553326725 0.545454545454545 23.2 23 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.277316632462835 0.377628294731689 0.773339553326725 0.545454545454545 23.2 23 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.000769260560229164 0.00228053703584604 0.766134526432376 0.540372670807453 23.2 23 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.137272755875063 0.205836808862185 0.76342494366869 0.538461538461538 23.2 23 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.137272755875063 0.205836808862185 0.76342494366869 0.538461538461538 23.2 23 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.261059784264071 0.358233435880206 0.76342494366869 0.538461538461538 23.2 23 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.261059784264071 0.358233435880206 0.76342494366869 0.538461538461538 23.2 23 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.261059784264071 0.358233435880206 0.76342494366869 0.538461538461538 23.2 23 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.078487878879935 0.125775058160076 0.76342494366869 0.538461538461538 23.2 23 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.078487878879935 0.125775058160076 0.76342494366869 0.538461538461538 23.2 23 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.000992609426335728 0.00276847050614224 0.761405300960571 0.537037037037037 23.2 23 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.131607738313738 0.198177578434338 0.75952991844589 0.535714285714286 23.2 23 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.131607738313738 0.198177578434338 0.75952991844589 0.535714285714286 23.2 23 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0148400312619833 0.0303410409278768 0.757228312632418 0.534090909090909 23.2 23 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0702893641978161 0.115181762986521 0.756154229919464 0.533333333333333 23.2 23 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.126195000313272 0.190429995170504 0.756154229919464 0.533333333333333 23.2 23 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.246413906153238 0.339774213620211 0.756154229919464 0.533333333333333 23.2 23 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.233092536964342 0.322029786505106 0.750594272346527 0.529411764705882 23.2 23 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.233092536964342 0.322029786505106 0.750594272346527 0.529411764705882 23.2 23 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00366088875265248 0.00907568762199386 0.740103786359853 0.522012578616352 23.2 23 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00366088875265248 0.00907568762199386 0.740103786359853 0.522012578616352 23.2 23 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0908209719642298 0.145211509106853 0.739716094486432 0.521739130434783 23.2 23 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0774120388101046 0.124331073619389 0.735149945755034 0.518518518518518 23.2 23 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.172038662973443 0.249044778648229 0.733339231602928 0.517241379310345 23.2 23 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00623159045581554 0.0144187857213423 0.731762157986578 0.516129032258065 23.2 23 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.156658116460856 0.233918677569568 0.730376244808573 0.515151515151515 23.2 23 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.156658116460856 0.233918677569568 0.730376244808573 0.515151515151515 23.2 23 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 4.30980775157922e-06 1.83070341208873e-05 0.727512024240696 0.513131313131313 23.2 23 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00582809120292916 0.013640417404224 0.725380511259951 0.511627906976744 23.2 23 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00844612271619739 0.0187794259767951 0.721941730252862 0.50920245398773 23.2 23 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0971136040118631 0.153070069027088 0.721783583104943 0.509090909090909 23.2 23 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0534836675171161 0.093154539628955 0.717234526908903 0.505882352941176 23.2 23 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0534836675171161 0.093154539628955 0.717234526908903 0.505882352941176 23.2 23 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0557546964762736 0.0969913607405102 0.708894590549498 0.5 23.2 23 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.136420034850495 0.204990189643352 0.708894590549498 0.5 23.2 23 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.371363414468377 0.476496908626721 0.708894590549498 0.5 23.2 23 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.371363414468377 0.476496908626721 0.708894590549498 0.5 23.2 23 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.371363414468377 0.476496908626721 0.708894590549498 0.5 23.2 23 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.207193851743823 0.2870855414133 0.708894590549498 0.5 23.2 23 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.207193851743823 0.2870855414133 0.708894590549498 0.5 23.2 23 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.285955109818132 0.388647680297232 0.708894590549498 0.5 23.2 23 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.285955109818132 0.388647680297232 0.708894590549498 0.5 23.2 23 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.323469686852155 0.431798653274499 0.708894590549498 0.5 23.2 23 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.323469686852155 0.431798653274499 0.708894590549498 0.5 23.2 23 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.345782016733941 0.45350028554138 0.708894590549498 0.5 23.2 23 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.345782016733941 0.45350028554138 0.708894590549498 0.5 23.2 23 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.345782016733941 0.45350028554138 0.708894590549498 0.5 23.2 23 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.345782016733941 0.45350028554138 0.708894590549498 0.5 23.2 23 2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.401348956257112 0.508565952585815 0.708894590549498 0.5 23.2 23 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0366052143094714 0.0666955441259639 0.703312743379816 0.496062992125984 23.2 23 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00551734048729684 0.0129501704439114 0.700554654190092 0.494117647058824 23.2 23 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0919995547688982 0.146930826527657 0.699921241302035 0.493670886075949 23.2 23 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.112842169992234 0.173406488011824 0.698620755903853 0.492753623188406 23.2 23 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0486754881221958 0.0851970720761188 0.697273367753604 0.491803278688525 23.2 23 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.133516454165012 0.200839232850753 0.697273367753604 0.491803278688525 23.2 23 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.219436413034002 0.303752933606406 0.690717806176434 0.487179487179487 23.2 23 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0122202024539715 0.0255350192246717 0.688965826959753 0.485943775100402 23.2 23 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0483315141651876 0.0846991929274163 0.688925728843878 0.485915492957746 23.2 23 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0501363452022471 0.0876462152614221 0.68864045939094 0.485714285714286 23.2 23 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.254756896716026 0.350598707956388 0.687412936290422 0.484848484848485 23.2 23 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.268293920957945 0.366745676775366 0.686027023112417 0.483870967741935 23.2 23 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.268293920957945 0.366745676775366 0.686027023112417 0.483870967741935 23.2 23 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.268293920957945 0.366745676775366 0.686027023112417 0.483870967741935 23.2 23 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0629183846345287 0.1082622265235 0.683022525200976 0.481751824817518 23.2 23 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.315891027272368 0.423328905593681 0.680538806927518 0.48 23.2 23 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.315891027272368 0.423328905593681 0.680538806927518 0.48 23.2 23 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.315891027272368 0.423328905593681 0.680538806927518 0.48 23.2 23 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.315891027272368 0.423328905593681 0.680538806927518 0.48 23.2 23 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0756289093207334 0.121604449676162 0.677619829201726 0.477941176470588 23.2 23 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0506747947277946 0.0884788133713518 0.674407826684927 0.475675675675676 23.2 23 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.196885202850021 0.275590513428787 0.674030922161817 0.475409836065574 23.2 23 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0280210564017145 0.0539566485245463 0.672754866325405 0.474509803921569 23.2 23 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0871036885513349 0.139424689323453 0.672673699061567 0.474452554744526 23.2 23 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.378221935238213 0.484001631154656 0.671584348941629 0.473684210526316 23.2 23 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.378221935238213 0.484001631154656 0.671584348941629 0.473684210526316 23.2 23 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.234748831340921 0.324003479144647 0.668768481650469 0.471698113207547 23.2 23 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.432729113492056 0.537793474671787 0.661634951179531 0.466666666666667 23.2 23 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.358783433831225 0.470118624624156 0.658259262653105 0.464285714285714 23.2 23 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.465909383214926 0.574513910151507 0.654364237430305 0.461538461538462 23.2 23 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.264477870824285 0.362574190927705 0.652633115109061 0.46031746031746 23.2 23 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.504709226085675 0.613322996344932 0.644449627772271 0.454545454545455 23.2 23 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.250715915886723 0.345371489164382 0.641736155655335 0.452631578947368 23.2 23 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.398652307992656 0.508565952585815 0.640291888238256 0.451612903225806 23.2 23 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.453712974218279 0.560445800618587 0.638005131494548 0.45 23.2 23 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.420442921391917 0.522981011486624 0.635560667389205 0.448275862068966 23.2 23 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.483893296358518 0.59360358682601 0.630128524932887 0.444444444444444 23.2 23 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.443974347809488 0.548892699333537 0.630128524932887 0.444444444444444 23.2 23 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.443974347809488 0.548892699333537 0.630128524932887 0.444444444444444 23.2 23 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.310047354145749 0.41859334435427 0.628504482342853 0.443298969072165 23.2 23 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.308652439437486 0.417105813218939 0.627099060870709 0.442307692307692 23.2 23 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.399025654373346 0.508565952585815 0.621837360131138 0.43859649122807 23.2 23 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.482125736648501 0.593481767518008 0.614375311809565 0.433333333333333 23.2 23 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.482125736648501 0.593481767518008 0.614375311809565 0.433333333333333 23.2 23 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0719254131883777 0.11630666246257 0.608611941154691 0.429268292682927 23.2 23 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.556004908075665 0.663197807369381 0.607623934756712 0.428571428571429 23.2 23 2 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.556004908075665 0.663197807369381 0.607623934756712 0.428571428571429 23.2 23 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.489403304486037 0.59984573840106 0.603314545148509 0.425531914893617 23.2 23 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.560745195355103 0.667732563171809 0.596963865725893 0.421052631578947 23.2 23 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.560745195355103 0.667732563171809 0.596963865725893 0.421052631578947 23.2 23 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.455870806257577 0.562622859761086 0.596508862779455 0.420731707317073 23.2 23 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.599956234383745 0.712041469164361 0.590745492124581 0.416666666666667 23.2 23 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.599956234383745 0.712041469164361 0.590745492124581 0.416666666666667 23.2 23 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.599956234383745 0.712041469164361 0.590745492124581 0.416666666666667 23.2 23 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.597441282989216 0.710835238874293 0.58379554515841 0.411764705882353 23.2 23 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.651444356851128 0.762197541817554 0.561765524586394 0.39622641509434 23.2 23 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.689791517271811 0.792230289812581 0.558523010735968 0.393939393939394 23.2 23 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.669699092663297 0.776676290839341 0.551362459316276 0.388888888888889 23.2 23 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.669699092663297 0.776676290839341 0.551362459316276 0.388888888888889 23.2 23 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.683735516364257 0.789325823612111 0.545303531191921 0.384615384615385 23.2 23 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.687674060557142 0.790436339396456 0.545303531191921 0.384615384615385 23.2 23 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.704074990737491 0.807331758113981 0.54209586336138 0.382352941176471 23.2 23 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.696472039928198 0.799257832917601 0.540110164228189 0.380952380952381 23.2 23 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.724114816171321 0.820394413544419 0.536460771226647 0.378378378378378 23.2 23 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.71047683328306 0.807768811661386 0.531670942912123 0.375 23.2 23 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.71047683328306 0.807768811661386 0.531670942912123 0.375 23.2 23 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.71047683328306 0.807768811661386 0.531670942912123 0.375 23.2 23 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.71047683328306 0.807768811661386 0.531670942912123 0.375 23.2 23 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.758879457314994 0.856372297985121 0.52754946273451 0.372093023255814 23.2 23 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.758381560044683 0.856372297985121 0.519856033069631 0.366666666666667 23.2 23 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.753091629609632 0.851190936405485 0.515559702217816 0.363636363636364 23.2 23 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.770632261411825 0.868945885886709 0.510404105195638 0.36 23.2 23 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.800467478334595 0.88712244678359 0.503086483615772 0.354838709677419 23.2 23 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.800467478334595 0.88712244678359 0.503086483615772 0.354838709677419 23.2 23 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.985146027827329 1 0.480218916178692 0.338709677419355 23.2 23 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.842827370752069 0.932615356594241 0.472596393699665 0.333333333333333 23.2 23 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.90037289318266 0.972102144915725 0.472596393699665 0.333333333333333 23.2 23 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.888524430591375 0.966643933280984 0.457351348741611 0.32258064516129 23.2 23 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.8827414512167 0.961087287743966 0.455717951067534 0.321428571428571 23.2 23 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.870803638128831 0.958355434692441 0.451114739440589 0.318181818181818 23.2 23 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.870803638128831 0.958355434692441 0.451114739440589 0.318181818181818 23.2 23 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.970760030394055 1 0.4486674623731 0.316455696202532 23.2 23 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.919564502776928 0.9898186743204 0.447722899294419 0.315789473684211 23.2 23 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999992083099813 1 0.438491499308968 0.309278350515464 23.2 23 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999912792172246 1 0.435463819908977 0.307142857142857 23.2 23 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.98517268729291 1 0.419346095818013 0.295774647887324 23.2 23 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.977262230845515 1 0.405082623171142 0.285714285714286 23.2 23 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999966865682604 1 0.405082623171141 0.285714285714286 23.2 23 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.982342952036383 1 0.364574360854027 0.257142857142857 23.2 23 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999996037770173 1 0.362502915621902 0.255681818181818 23.2 23 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.993426676554819 1 0.324066098536913 0.228571428571429 23.2 23 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999991600562092 1 0.315064262466443 0.222222222222222 23.2 23 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.311889811459225 0.219983207388749 23.2 23 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999230040812294 1 0.295372746062291 0.208333333333333 23.2 23 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999998478202829 1 0.267804623096477 0.188888888888889 23.2 23 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.260227128176398 0.183544303797468 23.2 23 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.999376128858391 1 0.228675674370806 0.161290322580645 23.2 23 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0160072972059564 0.0112903225806452 23.2 23 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 7.82715227765803e-05 0.000283410628272452 2.85938566552901 1 24.1 24 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 2.02688558701154e-05 8.12467095864064e-05 2.85938566552901 1 24.1 24 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 2.02688558701154e-05 8.12467095864064e-05 2.85938566552901 1 24.1 24 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 2.02688558701154e-05 8.12467095864064e-05 2.85938566552901 1 24.1 24 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.000302232867661208 0.000945224990509667 2.85938566552901 1 24.1 24 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.000302232867661208 0.000945224990509667 2.85938566552901 1 24.1 24 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.000302232867661208 0.000945224990509667 2.85938566552901 1 24.1 24 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00116692505841782 0.0032687684215129 2.85938566552901 1 24.1 24 1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00116692505841782 0.0032687684215129 2.85938566552901 1 24.1 24 1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.00116692505841782 0.0032687684215129 2.85938566552901 1 24.1 24 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 5.25471644924661e-09 3.66542230748918e-08 2.69118650873319 0.941176470588235 24.1 24 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 2.50700765937993e-07 1.36163049591513e-06 2.65514383227694 0.928571428571429 24.1 24 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 9.01009863243077e-07 4.53051955969929e-06 2.63943292202678 0.923076923076923 24.1 24 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 3.21975636130709e-06 1.47797203294839e-05 2.62110352673493 0.916666666666667 24.1 24 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 3.21975636130709e-06 1.47797203294839e-05 2.62110352673493 0.916666666666667 24.1 24 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 3.21975636130709e-06 1.47797203294839e-05 2.62110352673493 0.916666666666667 24.1 24 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 1.14293866162978e-05 4.88408923573325e-05 2.59944151411728 0.909090909090909 24.1 24 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 4.02533133628371e-05 0.000153979744396014 2.57344709897611 0.9 24.1 24 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00014043336192967 0.000488598225002251 2.5416761471369 0.888888888888889 24.1 24 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00014043336192967 0.000488598225002251 2.5416761471369 0.888888888888889 24.1 24 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00014043336192967 0.000488598225002251 2.5416761471369 0.888888888888889 24.1 24 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 4.21348211194124e-07 2.21246680638095e-06 2.50196245733788 0.875 24.1 24 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 4.21348211194124e-07 2.21246680638095e-06 2.50196245733788 0.875 24.1 24 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.000484290191121834 0.00144778349152599 2.50196245733788 0.875 24.1 24 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.000484290191121834 0.00144778349152599 2.50196245733788 0.875 24.1 24 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.000484290191121834 0.00144778349152599 2.50196245733788 0.875 24.1 24 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.000484290191121834 0.00144778349152599 2.50196245733788 0.875 24.1 24 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.000484290191121834 0.00144778349152599 2.50196245733788 0.875 24.1 24 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00164600093696897 0.00444451486395986 2.45090199902487 0.857142857142857 24.1 24 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 1.59728621006592e-05 6.72466945835446e-05 2.41948017852455 0.846153846153846 24.1 24 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 1.59728621006592e-05 6.72466945835446e-05 2.41948017852455 0.846153846153846 24.1 24 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 5.24775378912511e-05 0.000193962432257793 2.38282138794084 0.833333333333333 24.1 24 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00549038601220084 0.0127452190788936 2.38282138794084 0.833333333333333 24.1 24 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00549038601220084 0.0127452190788936 2.38282138794084 0.833333333333333 24.1 24 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00549038601220084 0.0127452190788936 2.38282138794084 0.833333333333333 24.1 24 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00549038601220084 0.0127452190788936 2.38282138794084 0.833333333333333 24.1 24 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00549038601220084 0.0127452190788936 2.38282138794084 0.833333333333333 24.1 24 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 8.48653439620337e-13 1.13927721186768e-11 2.38282138794084 0.833333333333333 24.1 24 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 1.81254409332958e-06 8.77296001635373e-06 2.35478819514154 0.823529411764706 24.1 24 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000169960983722265 0.000571759999614143 2.33949736270555 0.818181818181818 24.1 24 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000169960983722265 0.000571759999614143 2.33949736270555 0.818181818181818 24.1 24 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000169960983722265 0.000571759999614143 2.33949736270555 0.818181818181818 24.1 24 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000169960983722265 0.000571759999614143 2.33949736270555 0.818181818181818 24.1 24 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000169960983722265 0.000571759999614143 2.33949736270555 0.818181818181818 24.1 24 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.000169960983722265 0.000571759999614143 2.33949736270555 0.818181818181818 24.1 24 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 2.81349269251060e-11 3.17746039797031e-10 2.33949736270555 0.818181818181818 24.1 24 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 5.79592608193004e-06 2.57737587955827e-05 2.32325085324232 0.8125 24.1 24 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 5.79592608193004e-06 2.57737587955827e-05 2.32325085324232 0.8125 24.1 24 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 6.49665665571517e-07 3.36424076461286e-06 2.28750853242321 0.8 24.1 24 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 1.82979959875394e-05 7.48219778455995e-05 2.28750853242321 0.8 24.1 24 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 1.82979959875394e-05 7.48219778455995e-05 2.28750853242321 0.8 24.1 24 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 1.82979959875394e-05 7.48219778455995e-05 2.28750853242321 0.8 24.1 24 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000541153556197 0.00158123513443189 2.28750853242321 0.8 24.1 24 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000541153556197 0.00158123513443189 2.28750853242321 0.8 24.1 24 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.000541153556197 0.00158123513443189 2.28750853242321 0.8 24.1 24 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 5.69295201638065e-05 0.000207719762033581 2.24666016577279 0.785714285714286 24.1 24 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.56632189225868e-08 1.655652972322e-07 2.22396662874479 0.777777777777778 24.1 24 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00168778909329441 0.00453155449010933 2.22396662874479 0.777777777777778 24.1 24 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00168778909329441 0.00453155449010933 2.22396662874479 0.777777777777778 24.1 24 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00168778909329441 0.00453155449010933 2.22396662874479 0.777777777777778 24.1 24 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 7.7521433550738e-08 4.63499999759245e-07 2.19952743502232 0.769230769230769 24.1 24 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000174159790526558 0.0005817591124866 2.19952743502232 0.769230769230769 24.1 24 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.000174159790526558 0.0005817591124866 2.19952743502232 0.769230769230769 24.1 24 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 1.87419175448816e-05 7.5766331438541e-05 2.18658903834571 0.764705882352941 24.1 24 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 1.87419175448816e-05 7.5766331438541e-05 2.18658903834571 0.764705882352941 24.1 24 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 1.87419175448816e-05 7.5766331438541e-05 2.18658903834571 0.764705882352941 24.1 24 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 1.87419175448816e-05 7.5766331438541e-05 2.18658903834571 0.764705882352941 24.1 24 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 1.16539156701841e-10 1.1436911723222e-09 2.18216274474582 0.763157894736842 24.1 24 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.06712106511024e-06 9.87084991829487e-06 2.17857955468877 0.761904761904762 24.1 24 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 2.31691185220583e-07 1.27789363011197e-06 2.17313310580205 0.76 24.1 24 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 2.31691185220583e-07 1.27789363011197e-06 2.17313310580205 0.76 24.1 24 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 2.31691185220583e-07 1.27789363011197e-06 2.17313310580205 0.76 24.1 24 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 2.31691185220583e-07 1.27789363011197e-06 2.17313310580205 0.76 24.1 24 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.58097170540003e-12 2.00391412367157e-11 2.14453924914676 0.75 24.1 24 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 8.83364096964291e-09 6.01448377980951e-08 2.14453924914676 0.75 24.1 24 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 6.84485566548737e-07 3.51632837977925e-06 2.14453924914676 0.75 24.1 24 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 6.84485566548737e-07 3.51632837977925e-06 2.14453924914676 0.75 24.1 24 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 6.12629334260402e-06 2.70736503929364e-05 2.14453924914676 0.75 24.1 24 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 6.12629334260402e-06 2.70736503929364e-05 2.14453924914676 0.75 24.1 24 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 5.58042057043677e-05 0.00020413723577716 2.14453924914676 0.75 24.1 24 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 5.58042057043677e-05 0.00020413723577716 2.14453924914676 0.75 24.1 24 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 5.58042057043677e-05 0.00020413723577716 2.14453924914676 0.75 24.1 24 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.000522411321215304 0.00154551207918789 2.14453924914676 0.75 24.1 24 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000522411321215304 0.00154551207918789 2.14453924914676 0.75 24.1 24 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000522411321215304 0.00154551207918789 2.14453924914676 0.75 24.1 24 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000522411321215304 0.00154551207918789 2.14453924914676 0.75 24.1 24 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00513113317451039 0.0121693375122138 2.14453924914676 0.75 24.1 24 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00513113317451039 0.0121693375122138 2.14453924914676 0.75 24.1 24 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00513113317451039 0.0121693375122138 2.14453924914676 0.75 24.1 24 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00513113317451039 0.0121693375122138 2.14453924914676 0.75 24.1 24 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00513113317451039 0.0121693375122138 2.14453924914676 0.75 24.1 24 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00513113317451039 0.0121693375122138 2.14453924914676 0.75 24.1 24 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.60394352777264e-12 5.50538793279031e-11 2.12932975092586 0.74468085106383 24.1 24 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 2.57418837318346e-08 1.655652972322e-07 2.12147968732798 0.741935483870968 24.1 24 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.55393695038452e-12 2.00391412367157e-11 2.11594539249147 0.74 24.1 24 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.12084190498326e-23 1.58605643956828e-21 2.10843589478402 0.737373737373737 24.1 24 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 9.85865723079141e-10 7.62438545620444e-09 2.10691575354769 0.736842105263158 24.1 24 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 1.78875322523708e-05 7.37795895510829e-05 2.10691575354769 0.736842105263158 24.1 24 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 1.78875322523708e-05 7.37795895510829e-05 2.10691575354769 0.736842105263158 24.1 24 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 7.42343293353343e-08 4.4760784171263e-07 2.09688282138794 0.733333333333333 24.1 24 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 7.42343293353343e-08 4.4760784171263e-07 2.09688282138794 0.733333333333333 24.1 24 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000163166211648541 0.000559483178737046 2.09688282138794 0.733333333333333 24.1 24 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000163166211648541 0.000559483178737046 2.09688282138794 0.733333333333333 24.1 24 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000163166211648541 0.000559483178737046 2.09688282138794 0.733333333333333 24.1 24 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.27922958554454e-10 2.95338208875309e-09 2.09223341380171 0.731707317073171 24.1 24 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 6.50151939753013e-07 3.36424076461286e-06 2.0895510632712 0.730769230769231 24.1 24 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.45294959714333e-24 1.96541891069399e-22 2.08441198047909 0.728971962616822 24.1 24 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.74701486962518e-16 6.51500359912772e-15 2.08326669917114 0.728571428571429 24.1 24 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00153100041612963 0.00414185093565107 2.07955321129383 0.727272727272727 24.1 24 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00153100041612963 0.00414185093565107 2.07955321129383 0.727272727272727 24.1 24 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00153100041612963 0.00414185093565107 2.07955321129383 0.727272727272727 24.1 24 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00153100041612963 0.00414185093565107 2.07955321129383 0.727272727272727 24.1 24 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00153100041612963 0.00414185093565107 2.07955321129383 0.727272727272727 24.1 24 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00153100041612963 0.00414185093565107 2.07955321129383 0.727272727272727 24.1 24 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 9.21175840104934e-17 2.38333312812604e-15 2.07599233250736 0.726027397260274 24.1 24 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 9.21175840104934e-17 2.38333312812604e-15 2.07599233250736 0.726027397260274 24.1 24 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 9.32230382229461e-10 7.51108485864759e-09 2.07305460750853 0.725 24.1 24 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 2.11685444735305e-07 1.19062603896577e-06 2.07058961986584 0.724137931034483 24.1 24 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.10306120650118e-28 1.50417559142904e-26 2.06755578892098 0.723076923076923 24.1 24 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 3.07615814298469e-10 2.82411163707562e-09 2.06141757282324 0.720930232558139 24.1 24 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 1.84881397567829e-06 8.85812217976502e-06 2.05875767918089 0.72 24.1 24 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.84881397567829e-06 8.85812217976502e-06 2.05875767918089 0.72 24.1 24 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 6.70300203507586e-36 8.67124717810269e-34 2.05202971290905 0.717647058823529 24.1 24 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.955174194578e-12 4.76967193125804e-11 2.05012557151137 0.716981132075472 24.1 24 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 6.12598609846998e-15 1.21073308585039e-13 2.04851510366257 0.716417910447761 24.1 24 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 6.12598609846998e-15 1.21073308585039e-13 2.04851510366257 0.716417910447761 24.1 24 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.87545203931503e-35 2.22397354328774e-33 2.04725245875154 0.715976331360947 24.1 24 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 2.24736582107469e-08 1.46027468647913e-07 2.04241833252072 0.714285714285714 24.1 24 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 5.96370761788439e-07 3.10855528946867e-06 2.04241833252072 0.714285714285714 24.1 24 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.62742240363386e-05 6.81124141285583e-05 2.04241833252072 0.714285714285714 24.1 24 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.000467235466433436 0.00141462993347825 2.04241833252072 0.714285714285714 24.1 24 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000467235466433436 0.00141462993347825 2.04241833252072 0.714285714285714 24.1 24 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000467235466433436 0.00141462993347825 2.04241833252072 0.714285714285714 24.1 24 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000467235466433436 0.00141462993347825 2.04241833252072 0.714285714285714 24.1 24 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000467235466433436 0.00141462993347825 2.04241833252072 0.714285714285714 24.1 24 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0151013487002806 0.0322177199407785 2.04241833252072 0.714285714285714 24.1 24 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.10173293016324e-11 1.27460647123763e-10 2.03456287739564 0.711538461538462 24.1 24 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.82777423632575e-10 2.61293684304645e-09 2.03334091770952 0.711111111111111 24.1 24 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.92771418588334e-07 1.0972549146048e-06 2.02924144005285 0.709677419354839 24.1 24 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 5.18360024448006e-06 2.32689689208048e-05 2.02539817974972 0.708333333333333 24.1 24 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 5.18360024448006e-06 2.32689689208048e-05 2.02539817974972 0.708333333333333 24.1 24 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.39263998944406e-09 1.72828766750198e-08 2.02249230000832 0.707317073170732 24.1 24 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 6.24294986737732e-08 3.80119094856559e-07 2.01838988154989 0.705882352941177 24.1 24 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 6.24294986737732e-08 3.80119094856559e-07 2.01838988154989 0.705882352941177 24.1 24 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000144753697287135 0.00050117885946373 2.01838988154989 0.705882352941177 24.1 24 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.000144753697287135 0.00050117885946373 2.01838988154989 0.705882352941177 24.1 24 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 8.54645749889373e-33 7.60100563807861e-31 2.01735798488243 0.705521472392638 24.1 24 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.93812069031448e-13 5.71831198195664e-12 2.01563251832373 0.704918032786885 24.1 24 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.93812069031448e-13 5.71831198195664e-12 2.01563251832373 0.704918032786885 24.1 24 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 7.81550574646129e-10 6.78138090074049e-09 2.01456717344089 0.704545454545455 24.1 24 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.65825436414954e-06 8.08115054857806e-06 2.01216028315004 0.703703703703704 24.1 24 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 1.65825436414954e-06 8.08115054857806e-06 2.01216028315004 0.703703703703704 24.1 24 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 9.85884198828699e-51 1.75364151866655e-48 2.00485661606057 0.701149425287356 24.1 24 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 4.53304230418265e-05 0.000169304965849132 2.00156996587031 0.7 24.1 24 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 4.53304230418265e-05 0.000169304965849132 2.00156996587031 0.7 24.1 24 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 4.53304230418265e-05 0.000169304965849132 2.00156996587031 0.7 24.1 24 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 4.53304230418265e-05 0.000169304965849132 2.00156996587031 0.7 24.1 24 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 4.53304230418265e-05 0.000169304965849132 2.00156996587031 0.7 24.1 24 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 4.53304230418265e-05 0.000169304965849132 2.00156996587031 0.7 24.1 24 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00436327201318836 0.0105058140012979 2.00156996587031 0.7 24.1 24 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00436327201318836 0.0105058140012979 2.00156996587031 0.7 24.1 24 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00436327201318836 0.0105058140012979 2.00156996587031 0.7 24.1 24 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00436327201318836 0.0105058140012979 2.00156996587031 0.7 24.1 24 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00436327201318836 0.0105058140012979 2.00156996587031 0.7 24.1 24 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00436327201318836 0.0105058140012979 2.00156996587031 0.7 24.1 24 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.93401586370702e-56 5.50420914811017e-54 2.00059406632576 0.699658703071672 24.1 24 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.54386085441286e-13 5.25303541232239e-12 1.99703125846471 0.698412698412698 24.1 24 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 8.78508929429895e-20 3.04906879653351e-18 1.99290516082325 0.696969696969697 24.1 24 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 1.43101736750252e-05 6.06052891058358e-05 1.98913785428105 0.695652173913043 24.1 24 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 3.15974431387587e-21 1.24897671073482e-19 1.9856844899507 0.694444444444444 24.1 24 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 5.45520215485443e-17 1.46915566893112e-15 1.98475005019072 0.694117647058824 24.1 24 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 5.45520215485443e-17 1.46915566893112e-15 1.98475005019072 0.694117647058824 24.1 24 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 5.45520215485443e-17 1.46915566893112e-15 1.98475005019072 0.694117647058824 24.1 24 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 7.42080475310656e-11 7.43648250962721e-10 1.97957469152008 0.692307692307692 24.1 24 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 7.42080475310656e-11 7.43648250962721e-10 1.97957469152008 0.692307692307692 24.1 24 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 4.54580355651012e-06 2.05354871775045e-05 1.97957469152008 0.692307692307692 24.1 24 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00130597726526498 0.00361557519157991 1.97957469152008 0.692307692307692 24.1 24 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00130597726526498 0.00361557519157991 1.97957469152008 0.692307692307692 24.1 24 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00130597726526498 0.00361557519157991 1.97957469152008 0.692307692307692 24.1 24 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00130597726526498 0.00361557519157991 1.97957469152008 0.692307692307692 24.1 24 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 5.80761508757643e-09 4.03133476566891e-08 1.9743377214367 0.69047619047619 24.1 24 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 3.39580611881974e-14 6.35820014089539e-13 1.97337883959044 0.690140845070423 24.1 24 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 7.92497208644722e-12 9.32002915621024e-11 1.97199011415794 0.689655172413793 24.1 24 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.59295227259653e-17 4.62606343654055e-16 1.9697990140311 0.688888888888889 24.1 24 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.88597683760472e-09 1.36925767342425e-08 1.9697990140311 0.688888888888889 24.1 24 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 2.59260215882963e-12 3.15322467693553e-11 1.96875734347899 0.688524590163934 24.1 24 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 6.13341621278214e-10 5.38756251283271e-09 1.96582764505119 0.6875 24.1 24 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000399362624725723 0.00123007146100585 1.96582764505119 0.6875 24.1 24 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.99718921707422e-10 1.89466683726441e-09 1.96232349595128 0.686274509803922 24.1 24 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.99718921707422e-10 1.89466683726441e-09 1.96232349595128 0.686274509803922 24.1 24 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.297987362121e-16 3.13056951914947e-15 1.96167156123502 0.686046511627907 24.1 24 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.97852354894526e-38 2.8154390101491e-36 1.96072159921989 0.685714285714286 24.1 24 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 1.49605877865831e-07 8.65403106516573e-07 1.96072159921989 0.685714285714286 24.1 24 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 6.51060410447517e-11 6.66517240335839e-10 1.95920869675136 0.685185185185185 24.1 24 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 9.64218389597197e-24 5.0817880310993e-22 1.95879175512617 0.68503937007874 24.1 24 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 4.60997996535493e-18 1.36666697722918e-16 1.95642177115143 0.684210526315789 24.1 24 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.60997996535493e-18 1.36666697722918e-16 1.95642177115143 0.684210526315789 24.1 24 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.60997996535493e-18 1.36666697722918e-16 1.95642177115143 0.684210526315789 24.1 24 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.21297621966719e-15 6.72362523615648e-14 1.95451678403249 0.683544303797468 24.1 24 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.55984835468532e-08 1.03240195754289e-07 1.95275118621493 0.682926829268293 24.1 24 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.55984835468532e-08 1.03240195754289e-07 1.95275118621493 0.682926829268293 24.1 24 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.6390818015523e-19 5.55336524668791e-18 1.95208059858231 0.682692307692308 24.1 24 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.13664069309431e-16 2.83761351977756e-15 1.94958113558796 0.681818181818182 24.1 24 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 3.88383513234956e-05 0.000148967584725968 1.94958113558796 0.681818181818182 24.1 24 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 3.88383513234956e-05 0.000148967584725968 1.94958113558796 0.681818181818182 24.1 24 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.32404608051488e-18 4.18692793905038e-17 1.94438225255973 0.68 24.1 24 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 1.22700210656838e-05 5.21201193327405e-05 1.94438225255973 0.68 24.1 24 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 1.22700210656838e-05 5.21201193327405e-05 1.94438225255973 0.68 24.1 24 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 5.65109162667823e-11 5.82717636577038e-10 1.94029741589469 0.678571428571429 24.1 24 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.92945566976507e-74 1.04215385451892e-71 1.93981797497156 0.678403755868545 24.1 24 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.01280562218134e-16 7.02823344321974e-15 1.93912361225531 0.67816091954023 24.1 24 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.80629169438934e-22 8.29146155198722e-21 1.93700319277772 0.67741935483871 24.1 24 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.80629169438934e-22 8.29146155198722e-21 1.93700319277772 0.67741935483871 24.1 24 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.80629169438934e-22 8.29146155198722e-21 1.93700319277772 0.67741935483871 24.1 24 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 3.99421342043093e-07 2.11292405103093e-06 1.93429030315198 0.676470588235294 24.1 24 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.99421342043093e-07 2.11292405103093e-06 1.93429030315198 0.676470588235294 24.1 24 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 3.99421342043093e-07 2.11292405103093e-06 1.93429030315198 0.676470588235294 24.1 24 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.07965171703192e-20 1.48854984444524e-18 1.93201734157366 0.675675675675676 24.1 24 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 6.88461877832588e-14 1.19473323433631e-12 1.93201734157366 0.675675675675676 24.1 24 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 6.88461877832588e-14 1.19473323433631e-12 1.93201734157366 0.675675675675676 24.1 24 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 1.34034703594184e-08 8.99676335917562e-08 1.92842289070561 0.674418604651163 24.1 24 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 4.34264802555475e-09 3.04413208884946e-08 1.92697729633477 0.673913043478261 24.1 24 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 9.93591337794307e-19 3.21336471291204e-17 1.92458650564453 0.673076923076923 24.1 24 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 3.26368840894894e-19 1.08005316417078e-17 1.92407259736532 0.672897196261682 24.1 24 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.49105560653628e-10 1.44338240006879e-09 1.92358672044679 0.672727272727273 24.1 24 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.85854892678672e-11 5.04650738891789e-10 1.92269036130399 0.672413793103448 24.1 24 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 4.85854892678672e-11 5.04650738891789e-10 1.92269036130399 0.672413793103448 24.1 24 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.85854892678672e-11 5.04650738891789e-10 1.92269036130399 0.672413793103448 24.1 24 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 3.80378262618954e-21 1.46291423704533e-19 1.92227607766656 0.672268907563025 24.1 24 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 5.17379601948906e-12 6.13525977977745e-11 1.9211497440273 0.671875 24.1 24 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 5.91995882739968e-14 1.05301267642372e-12 1.91879827555236 0.671052631578947 24.1 24 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 5.91995882739968e-14 1.05301267642372e-12 1.91879827555236 0.671052631578947 24.1 24 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 8.95084630178816e-88 6.36852714372227e-85 1.91350523624755 0.669201520912547 24.1 24 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 5.4301670263203e-15 1.10387538263626e-13 1.90625711035267 0.666666666666667 24.1 24 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 5.4301670263203e-15 1.10387538263626e-13 1.90625711035267 0.666666666666667 24.1 24 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.54447904073463e-13 2.46943109546671e-12 1.90625711035267 0.666666666666667 24.1 24 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.54447904073463e-13 2.46943109546671e-12 1.90625711035267 0.666666666666667 24.1 24 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.54447904073463e-13 2.46943109546671e-12 1.90625711035267 0.666666666666667 24.1 24 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.54447904073463e-13 2.46943109546671e-12 1.90625711035267 0.666666666666667 24.1 24 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.54447904073463e-13 2.46943109546671e-12 1.90625711035267 0.666666666666667 24.1 24 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.44286480394218e-12 1.88366662019241e-11 1.90625711035267 0.666666666666667 24.1 24 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.44286480394218e-12 1.88366662019241e-11 1.90625711035267 0.666666666666667 24.1 24 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.44286480394218e-12 1.88366662019241e-11 1.90625711035267 0.666666666666667 24.1 24 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 3.25633205361154e-05 0.000127301112974978 1.90625711035267 0.666666666666667 24.1 24 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 3.25633205361154e-05 0.000127301112974978 1.90625711035267 0.666666666666667 24.1 24 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000103442821052803 0.000367080135556454 1.90625711035267 0.666666666666667 24.1 24 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000103442821052803 0.000367080135556454 1.90625711035267 0.666666666666667 24.1 24 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000103442821052803 0.000367080135556454 1.90625711035267 0.666666666666667 24.1 24 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00354817860595828 0.00870527268323901 1.90625711035267 0.666666666666667 24.1 24 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 3.3810024207809e-07 1.81553450746084e-06 1.90625711035267 0.666666666666667 24.1 24 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.28887163771571e-06 1.50484383937925e-05 1.90625711035267 0.666666666666667 24.1 24 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000331532239366532 0.00103006632449471 1.90625711035267 0.666666666666667 24.1 24 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000331532239366532 0.00103006632449471 1.90625711035267 0.666666666666667 24.1 24 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00107537397600323 0.00304832105149919 1.90625711035267 0.666666666666667 24.1 24 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00107537397600323 0.00304832105149919 1.90625711035267 0.666666666666667 24.1 24 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0120178213369423 0.0261889123468131 1.90625711035267 0.666666666666667 24.1 24 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0120178213369423 0.0261889123468131 1.90625711035267 0.666666666666667 24.1 24 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0120178213369423 0.0261889123468131 1.90625711035267 0.666666666666667 24.1 24 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0120178213369423 0.0261889123468131 1.90625711035267 0.666666666666667 24.1 24 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 3.90107609373814e-10 3.49134042854678e-09 1.90625711035267 0.666666666666667 24.1 24 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.5040101763582e-11 3.86527634182768e-10 1.89088406914015 0.661290322580645 24.1 24 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.01167542891714e-09 7.78169802891398e-09 1.88827355270784 0.660377358490566 24.1 24 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 9.57948993665003e-09 6.49124484754904e-08 1.88597777939147 0.659574468085106 24.1 24 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 8.7823431504951e-07 4.43165755431012e-06 1.87902486591906 0.657142857142857 24.1 24 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 8.7823431504951e-07 4.43165755431012e-06 1.87902486591906 0.657142857142857 24.1 24 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.07818054006056e-15 2.39726704454091e-14 1.87551102792763 0.655913978494624 24.1 24 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 8.46743070106792e-10 7.12967685657968e-09 1.87159789016444 0.654545454545455 24.1 24 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 8.46743070106792e-10 7.12967685657968e-09 1.87159789016444 0.654545454545455 24.1 24 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 8.46743070106792e-10 7.12967685657968e-09 1.87159789016444 0.654545454545455 24.1 24 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 8.46743070106792e-10 7.12967685657968e-09 1.87159789016444 0.654545454545455 24.1 24 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 8.46743070106792e-10 7.12967685657968e-09 1.87159789016444 0.654545454545455 24.1 24 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.21623053224548e-21 5.09028249230976e-20 1.87042520978213 0.654135338345865 24.1 24 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 2.68602096941231e-05 0.000106172439985381 1.86959831976897 0.653846153846154 24.1 24 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 2.68602096941231e-05 0.000106172439985381 1.86959831976897 0.653846153846154 24.1 24 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 7.99034555223788e-09 5.49288005837416e-08 1.86735390401895 0.653061224489796 24.1 24 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 8.48286844143777e-05 0.000304058483429873 1.86481673838848 0.652173913043478 24.1 24 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 8.48286844143777e-05 0.000304058483429873 1.86481673838848 0.652173913043478 24.1 24 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 7.51533520045519e-11 7.47854684632709e-10 1.86087003629666 0.650793650793651 24.1 24 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 2.34228065703677e-07 1.28689782817117e-06 1.85860068259386 0.65 24.1 24 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 7.25059989659849e-07 3.69806582539772e-06 1.85473664791071 0.648648648648649 24.1 24 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 6.61522720046383e-09 4.56964480886409e-08 1.85019072475407 0.647058823529412 24.1 24 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 2.25012522607452e-06 1.06376352049968e-05 1.85019072475407 0.647058823529412 24.1 24 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.000866145658363131 0.00250005126136052 1.85019072475407 0.647058823529412 24.1 24 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000866145658363131 0.00250005126136052 1.85019072475407 0.647058823529412 24.1 24 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000866145658363131 0.00250005126136052 1.85019072475407 0.647058823529412 24.1 24 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.96332067542373e-13 3.03674491426952e-12 1.84813951552485 0.646341463414634 24.1 24 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 6.2596532079572e-34 6.851912703787e-32 1.84641944321156 0.645739910313901 24.1 24 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 5.97460369031376e-13 8.17486639549661e-12 1.84593251825291 0.645569620253165 24.1 24 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 5.97460369031376e-13 8.17486639549661e-12 1.84593251825291 0.645569620253165 24.1 24 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 5.97460369031376e-13 8.17486639549661e-12 1.84593251825291 0.645569620253165 24.1 24 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.90276088010405e-10 1.82947887323518e-09 1.84476494550259 0.645161290322581 24.1 24 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.2463841027839e-08 3.80119094856559e-07 1.84271520667425 0.644444444444444 24.1 24 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 5.81428796386478e-10 5.17108235786224e-09 1.84163822525597 0.644067796610169 24.1 24 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 2.18785098910064e-05 8.72076178568686e-05 1.83817649926865 0.642857142857143 24.1 24 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00281571250316178 0.00725862118115799 1.83817649926865 0.642857142857143 24.1 24 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.00281571250316178 0.00725862118115799 1.83817649926865 0.642857142857143 24.1 24 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00281571250316178 0.00725862118115799 1.83817649926865 0.642857142857143 24.1 24 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00281571250316178 0.00725862118115799 1.83817649926865 0.642857142857143 24.1 24 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00281571250316178 0.00725862118115799 1.83817649926865 0.642857142857143 24.1 24 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.00281571250316178 0.00725862118115799 1.83817649926865 0.642857142857143 24.1 24 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.00281571250316178 0.00725862118115799 1.83817649926865 0.642857142857143 24.1 24 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.92352541349052e-07 1.0972549146048e-06 1.83817649926865 0.642857142857143 24.1 24 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 4.93569789007237e-13 6.95395851244849e-12 1.83565499515443 0.641975308641975 24.1 24 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 4.93569789007237e-13 6.95395851244849e-12 1.83565499515443 0.641975308641975 24.1 24 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.66650062064573e-08 1.09788443665688e-07 1.83000682593857 0.64 24.1 24 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.83385613646049e-06 8.84602468536702e-06 1.82682973075465 0.638888888888889 24.1 24 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 4.21809955414059e-11 4.54723914056217e-10 1.8233763664243 0.63768115942029 24.1 24 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 8.18237568423296e-24 4.47827715333212e-22 1.82285836177474 0.6375 24.1 24 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 9.5970379285866e-17 2.43867588792477e-15 1.8196090598821 0.636363636363636 24.1 24 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00021650064307909 0.000686147917820812 1.8196090598821 0.636363636363636 24.1 24 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00021650064307909 0.000686147917820812 1.8196090598821 0.636363636363636 24.1 24 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00931974730804116 0.0207543042556222 1.8196090598821 0.636363636363636 24.1 24 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00931974730804116 0.0207543042556222 1.8196090598821 0.636363636363636 24.1 24 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00931974730804116 0.0207543042556222 1.8196090598821 0.636363636363636 24.1 24 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00931974730804116 0.0207543042556222 1.8196090598821 0.636363636363636 24.1 24 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00931974730804116 0.0207543042556222 1.8196090598821 0.636363636363636 24.1 24 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.32899097075958e-13 4.98647805409567e-12 1.8165508933949 0.635294117647059 24.1 24 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 1.35899084654039e-08 9.07907969308437e-08 1.81461013389341 0.634615384615385 24.1 24 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.18862146409617e-09 8.76377380004585e-09 1.81094425483504 0.633333333333333 24.1 24 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.18862146409617e-09 8.76377380004585e-09 1.81094425483504 0.633333333333333 24.1 24 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.18862146409617e-09 8.76377380004585e-09 1.81094425483504 0.633333333333333 24.1 24 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.18862146409617e-09 8.76377380004585e-09 1.81094425483504 0.633333333333333 24.1 24 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.18862146409617e-09 8.76377380004585e-09 1.81094425483504 0.633333333333333 24.1 24 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.18862146409617e-09 8.76377380004585e-09 1.81094425483504 0.633333333333333 24.1 24 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.18862146409617e-09 8.76377380004585e-09 1.81094425483504 0.633333333333333 24.1 24 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.18862146409617e-09 8.76377380004585e-09 1.81094425483504 0.633333333333333 24.1 24 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 1.76447499953997e-05 7.32025633919936e-05 1.81094425483504 0.633333333333333 24.1 24 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.71946471776533e-13 4.11680669508518e-12 1.80765760464478 0.632183908045977 24.1 24 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.71946471776533e-13 4.11680669508518e-12 1.80765760464478 0.632183908045977 24.1 24 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000687477169874746 0.00200057262317334 1.80592778875516 0.631578947368421 24.1 24 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000687477169874746 0.00200057262317334 1.80592778875516 0.631578947368421 24.1 24 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 5.4977032874039e-05 0.000202674398393154 1.8003539375553 0.62962962962963 24.1 24 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 8.50223404231091e-11 8.40186044597807e-10 1.79732813261824 0.628571428571429 24.1 24 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 7.2948542607485e-26 4.51329461436744e-24 1.79688170238162 0.628415300546448 24.1 24 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 6.68854111806979e-13 9.06456572477458e-12 1.79542820858798 0.627906976744186 24.1 24 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 3.88984070006341e-07 2.08091853992114e-06 1.79542820858798 0.627906976744186 24.1 24 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.35909497954985e-08 2.09648778767519e-07 1.79412433915546 0.627450980392157 24.1 24 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.26634568801975e-30 1.06000583179535e-28 1.79361464474092 0.627272727272727 24.1 24 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.93063246278527e-09 2.08514499727172e-08 1.79317406143345 0.627118644067797 24.1 24 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.93063246278527e-09 2.08514499727172e-08 1.79317406143345 0.627118644067797 24.1 24 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 2.57572990720183e-10 2.39559716205765e-09 1.79245071570475 0.626865671641791 24.1 24 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.27617312800118e-11 2.59119548891654e-10 1.79188168373151 0.626666666666667 24.1 24 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.000171937624211482 0.000577045375596553 1.78711604095563 0.625 24.1 24 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00220205956146574 0.0058150355739542 1.78711604095563 0.625 24.1 24 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00220205956146574 0.0058150355739542 1.78711604095563 0.625 24.1 24 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00220205956146574 0.0058150355739542 1.78711604095563 0.625 24.1 24 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00220205956146574 0.0058150355739542 1.78711604095563 0.625 24.1 24 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0317183745765642 0.060993577057366 1.78711604095563 0.625 24.1 24 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0317183745765642 0.060993577057366 1.78711604095563 0.625 24.1 24 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0317183745765642 0.060993577057366 1.78711604095563 0.625 24.1 24 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0317183745765642 0.060993577057366 1.78711604095563 0.625 24.1 24 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0317183745765642 0.060993577057366 1.78711604095563 0.625 24.1 24 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0317183745765642 0.060993577057366 1.78711604095563 0.625 24.1 24 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0317183745765642 0.060993577057366 1.78711604095563 0.625 24.1 24 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 6.88149304124335e-11 6.99454614120663e-10 1.78711604095563 0.625 24.1 24 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.63407590186972e-12 2.02199131161792e-11 1.78291106203574 0.623529411764706 24.1 24 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 4.36843909272352e-05 0.00016665653696905 1.77479110274214 0.620689655172414 24.1 24 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.15338085008407e-14 5.98301459955951e-13 1.77281911262799 0.62 24.1 24 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 9.52538467178158e-07 4.77275436195253e-06 1.77009588818463 0.619047619047619 24.1 24 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000540152327735861 0.00158123513443189 1.77009588818463 0.619047619047619 24.1 24 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 5.47190797282848e-17 1.46915566893112e-15 1.76677488276589 0.617886178861789 24.1 24 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 2.49457638805974e-07 1.3600698085092e-06 1.76430179362428 0.617021276595745 24.1 24 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000135488437657742 0.000474876962529476 1.75962194801785 0.615384615384615 24.1 24 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000135488437657742 0.000474876962529476 1.75962194801785 0.615384615384615 24.1 24 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00713570075106754 0.0162206104932414 1.75962194801785 0.615384615384615 24.1 24 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.46590904537081e-15 3.16058874479192e-14 1.75576312795641 0.614035087719298 24.1 24 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.86311787576069e-11 3.2080446749665e-10 1.75137372013652 0.6125 24.1 24 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.82422207749228e-13 2.85260221568298e-12 1.75064428501776 0.612244897959184 24.1 24 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.98478475246471e-07 1.12523852699493e-06 1.75064428501776 0.612244897959184 24.1 24 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.22314543287397e-10 2.921360478331e-09 1.74740235115662 0.611111111111111 24.1 24 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 3.22314543287397e-10 2.921360478331e-09 1.74740235115662 0.611111111111111 24.1 24 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 8.87424918849991e-06 3.87363699240349e-05 1.74740235115662 0.611111111111111 24.1 24 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0017062524596435 0.00457249952932712 1.74740235115662 0.611111111111111 24.1 24 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.30111940926209e-06 1.0771358287434e-05 1.74352784483476 0.609756097560976 24.1 24 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.30111940926209e-06 1.0771358287434e-05 1.74352784483476 0.609756097560976 24.1 24 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 2.30111940926209e-06 1.0771358287434e-05 1.74352784483476 0.609756097560976 24.1 24 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 3.64320349013191e-09 2.5792430678894e-08 1.74243813993174 0.609375 24.1 24 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 9.65937125180962e-10 7.51108485864759e-09 1.74049562249592 0.608695652173913 24.1 24 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000421323689890864 0.00129491060629525 1.74049562249592 0.608695652173913 24.1 24 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.14021314665764e-08 2.57271760161303e-07 1.73605558264261 0.607142857142857 24.1 24 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000106129295665999 0.000373816801318606 1.73605558264261 0.607142857142857 24.1 24 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000106129295665999 0.000373816801318606 1.73605558264261 0.607142857142857 24.1 24 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000106129295665999 0.000373816801318606 1.73605558264261 0.607142857142857 24.1 24 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.47856849799393e-20 2.66050074316134e-18 1.73407904877243 0.606451612903226 24.1 24 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.89193475494104e-09 2.07839553347531e-08 1.73296100941152 0.606060606060606 24.1 24 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 2.7097197632903e-05 0.000106517437103925 1.73296100941152 0.606060606060606 24.1 24 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 2.7097197632903e-05 0.000106517437103925 1.73296100941152 0.606060606060606 24.1 24 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.66962067449509e-10 6.69562590172178e-09 1.73174061433447 0.605633802816901 24.1 24 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 3.85780284436858e-26 2.49529702160749e-24 1.72924752153421 0.604761904761905 24.1 24 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.27427327756869e-16 3.12636357582801e-15 1.72893086752917 0.604651162790698 24.1 24 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.08299371937356e-22 1.37096876958393e-20 1.72855517633675 0.604519774011299 24.1 24 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.2707461017953e-20 4.75860974435451e-19 1.72609256638641 0.603658536585366 24.1 24 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 3.27442674019626e-08 2.05264724726841e-07 1.7254913498882 0.603448275862069 24.1 24 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 3.27442674019626e-08 2.05264724726841e-07 1.7254913498882 0.603448275862069 24.1 24 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 3.27442674019626e-08 2.05264724726841e-07 1.7254913498882 0.603448275862069 24.1 24 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.64841608522564e-09 5.91668081215196e-08 1.72470881412861 0.603174603174603 24.1 24 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.07564226856152e-10 5.36996207960438e-09 1.72346533264762 0.602739726027397 24.1 24 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 4.29844425750026e-11 4.59901216422772e-10 1.72252148525844 0.602409638554217 24.1 24 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 9.79891299672362e-08 5.83424819846766e-07 1.71563139931741 0.6 24.1 24 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 5.4795560561621e-06 2.45201517859078e-05 1.71563139931741 0.6 24.1 24 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00131398040357449 0.00363066818308057 1.71563139931741 0.6 24.1 24 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0234996453225733 0.0465738096017017 1.71563139931741 0.6 24.1 24 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.58295825618752e-08 1.655652972322e-07 1.71563139931741 0.6 24.1 24 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00542622029389959 0.0126998544049657 1.71563139931741 0.6 24.1 24 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00542622029389959 0.0126998544049657 1.71563139931741 0.6 24.1 24 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00542622029389959 0.0126998544049657 1.71563139931741 0.6 24.1 24 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00542622029389959 0.0126998544049657 1.71563139931741 0.6 24.1 24 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00542622029389959 0.0126998544049657 1.71563139931741 0.6 24.1 24 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00542622029389959 0.0126998544049657 1.71563139931741 0.6 24.1 24 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00542622029389959 0.0126998544049657 1.71563139931741 0.6 24.1 24 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.65721682713298e-14 6.75872668183147e-13 1.7105253534861 0.598214285714286 24.1 24 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.42626701706918e-09 1.04617420891208e-08 1.7076886613576 0.597222222222222 24.1 24 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.292893162348e-07 1.27789363011197e-06 1.69445076475793 0.592592592592593 24.1 24 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00100764920557342 0.00286776963906195 1.68963698417623 0.590909090909091 24.1 24 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00100764920557342 0.00286776963906195 1.68963698417623 0.590909090909091 24.1 24 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00100764920557342 0.00286776963906195 1.68963698417623 0.590909090909091 24.1 24 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00100764920557342 0.00286776963906195 1.68963698417623 0.590909090909091 24.1 24 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00100764920557342 0.00286776963906195 1.68963698417623 0.590909090909091 24.1 24 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 8.00339972360432e-16 1.83690932365951e-14 1.68963698417623 0.590909090909091 24.1 24 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.19147149535766e-98 1.69546393789395e-95 1.68846076629654 0.590497737556561 24.1 24 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00411050799446945 0.00999872286517954 1.68199156795824 0.588235294117647 24.1 24 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00411050799446945 0.00999872286517954 1.68199156795824 0.588235294117647 24.1 24 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 4.53551988425334e-13 6.51923716696213e-12 1.67890534489777 0.587155963302752 24.1 24 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.59914214845495e-06 1.20474895024475e-05 1.67833506454964 0.58695652173913 24.1 24 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.59914214845495e-06 1.20474895024475e-05 1.67833506454964 0.58695652173913 24.1 24 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 9.96676073413862e-06 4.29778803778159e-05 1.67378673104137 0.585365853658537 24.1 24 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 9.96676073413862e-06 4.29778803778159e-05 1.67378673104137 0.585365853658537 24.1 24 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 9.96676073413862e-06 4.29778803778159e-05 1.67378673104137 0.585365853658537 24.1 24 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 9.96676073413862e-06 4.29778803778159e-05 1.67378673104137 0.585365853658537 24.1 24 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.01994902391883e-28 8.06326367242495e-27 1.67164085061696 0.584615384615385 24.1 24 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000770464181841994 0.0022374908791044 1.66797497155859 0.583333333333333 24.1 24 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0173999434909572 0.0363051606856775 1.66797497155859 0.583333333333333 24.1 24 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0173999434909572 0.0363051606856775 1.66797497155859 0.583333333333333 24.1 24 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 3.8454230305914e-05 0.000148293684892454 1.66797497155859 0.583333333333333 24.1 24 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 3.8454230305914e-05 0.000148293684892454 1.66797497155859 0.583333333333333 24.1 24 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.24498789447796e-08 1.46027468647913e-07 1.66441852172584 0.582089552238806 24.1 24 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.24498789447796e-08 1.46027468647913e-07 1.66441852172584 0.582089552238806 24.1 24 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 7.49381990383596e-15 1.44104131394035e-13 1.65888023343668 0.580152671755725 24.1 24 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 7.49381990383596e-15 1.44104131394035e-13 1.65888023343668 0.580152671755725 24.1 24 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.28223692543549e-05 9.07157303043214e-05 1.64414675767918 0.575 24.1 24 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 3.54444378530966e-06 1.61658445721014e-05 1.63393466601658 0.571428571428571 24.1 24 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00044788478867021 0.00137062377264024 1.63393466601658 0.571428571428571 24.1 24 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0128956850816086 0.0278883888618981 1.63393466601658 0.571428571428571 24.1 24 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0128956850816086 0.0278883888618981 1.63393466601658 0.571428571428571 24.1 24 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0128956850816086 0.0278883888618981 1.63393466601658 0.571428571428571 24.1 24 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0128956850816086 0.0278883888618981 1.63393466601658 0.571428571428571 24.1 24 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 3.05489501036366e-08 1.94067660703013e-07 1.63393466601658 0.571428571428571 24.1 24 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 8.787590286215e-05 0.000314189471791054 1.63393466601658 0.571428571428571 24.1 24 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00234575117135932 0.00614733686343335 1.63393466601658 0.571428571428571 24.1 24 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00234575117135932 0.00614733686343335 1.63393466601658 0.571428571428571 24.1 24 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 6.74246427281285e-33 6.39635110680846e-31 1.63142863125275 0.570552147239264 24.1 24 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.887330786332e-52 7.90238815564348e-50 1.62246040572152 0.567415730337079 24.1 24 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.000340857063988664 0.00105673115916311 1.62031854379977 0.566666666666667 24.1 24 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00176987237596074 0.00473407592291755 1.61617450660335 0.565217391304348 24.1 24 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 5.13887102080423e-05 0.000190432642255323 1.61298678568303 0.564102564102564 24.1 24 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 7.91867338348768e-06 3.46716068452399e-05 1.60840443686007 0.5625 24.1 24 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 7.91867338348768e-06 3.46716068452399e-05 1.60840443686007 0.5625 24.1 24 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00957156980702887 0.0212154888401901 1.60840443686007 0.5625 24.1 24 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00957156980702887 0.0212154888401901 1.60840443686007 0.5625 24.1 24 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 4.04211782093226e-14 7.3742739220341e-13 1.60454735187959 0.561151079136691 24.1 24 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00133502126758811 0.0036674425941658 1.60125597269625 0.56 24.1 24 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00133502126758811 0.0036674425941658 1.60125597269625 0.56 24.1 24 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00133502126758811 0.0036674425941658 1.60125597269625 0.56 24.1 24 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00711582741300187 0.0162013158539227 1.58854759196056 0.555555555555556 24.1 24 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00711582741300187 0.0162013158539227 1.58854759196056 0.555555555555556 24.1 24 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00711582741300187 0.0162013158539227 1.58854759196056 0.555555555555556 24.1 24 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00711582741300187 0.0162013158539227 1.58854759196056 0.555555555555556 24.1 24 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00711582741300187 0.0162013158539227 1.58854759196056 0.555555555555556 24.1 24 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0563440661260914 0.100473190598281 1.58854759196056 0.555555555555556 24.1 24 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00100697841473463 0.00286776963906195 1.58854759196056 0.555555555555556 24.1 24 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00100697841473463 0.00286776963906195 1.58854759196056 0.555555555555556 24.1 24 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.51918559868618e-11 4.79910530367943e-10 1.58565932361154 0.554545454545455 24.1 24 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.76199481563849e-25 1.63763275943899e-23 1.57937186579761 0.552346570397112 24.1 24 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00395147353030241 0.00964484877121841 1.55966490847037 0.545454545454545 24.1 24 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.040515522940012 0.0768714521915161 1.55966490847037 0.545454545454545 24.1 24 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.040515522940012 0.0768714521915161 1.55966490847037 0.545454545454545 24.1 24 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.040515522940012 0.0768714521915161 1.55966490847037 0.545454545454545 24.1 24 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.040515522940012 0.0768714521915161 1.55966490847037 0.545454545454545 24.1 24 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00043257110081232 0.00132661352684468 1.55966490847037 0.545454545454545 24.1 24 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 3.7764318915504e-05 0.000146426773342676 1.55401394865707 0.543478260869565 24.1 24 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 3.7764318915504e-05 0.000146426773342676 1.55401394865707 0.543478260869565 24.1 24 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000326567480398674 0.00101909106273534 1.55223793271575 0.542857142857143 24.1 24 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.24733311435201e-11 3.61012111072102e-10 1.54688076987635 0.540983606557377 24.1 24 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000246619142787849 0.000778135344095585 1.54561387325892 0.540540540540541 24.1 24 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000246619142787849 0.000778135344095585 1.54561387325892 0.540540540540541 24.1 24 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.50574844009878e-06 7.41411775176664e-06 1.53966920451562 0.538461538461538 24.1 24 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00220668953614565 0.0058150355739542 1.53966920451562 0.538461538461538 24.1 24 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00220668953614565 0.0058150355739542 1.53966920451562 0.538461538461538 24.1 24 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0293748933541617 0.0570265664979156 1.53966920451562 0.538461538461538 24.1 24 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0293748933541617 0.0570265664979156 1.53966920451562 0.538461538461538 24.1 24 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0293748933541617 0.0570265664979156 1.53966920451562 0.538461538461538 24.1 24 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0293748933541617 0.0570265664979156 1.53966920451562 0.538461538461538 24.1 24 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0293748933541617 0.0570265664979156 1.53966920451562 0.538461538461538 24.1 24 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 7.8045388481544e-14 1.33805527481009e-12 1.53827709854409 0.537974683544304 24.1 24 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 8.80878364401087e-16 1.98966652784563e-14 1.5290832435984 0.53475935828877 24.1 24 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 2.74541679379503e-08 1.75189600787907e-07 1.52500568828214 0.533333333333333 24.1 24 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 8.04754276199967e-05 0.000290651100262069 1.52500568828214 0.533333333333333 24.1 24 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00123822472357913 0.00345488976794727 1.52500568828214 0.533333333333333 24.1 24 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0214322162675617 0.0433210848703697 1.52500568828214 0.533333333333333 24.1 24 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0214322162675617 0.0433210848703697 1.52500568828214 0.533333333333333 24.1 24 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 4.9015352180105e-22 2.11360139855422e-20 1.52430485846216 0.533088235294118 24.1 24 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 1.70033697833308e-07 9.75636903293536e-07 1.51794547676231 0.530864197530864 24.1 24 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0157152643461582 0.0333276023317185 1.51379241116242 0.529411764705882 24.1 24 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0157152643461582 0.0333276023317185 1.51379241116242 0.529411764705882 24.1 24 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0157152643461582 0.0333276023317185 1.51379241116242 0.529411764705882 24.1 24 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0157152643461582 0.0333276023317185 1.51379241116242 0.529411764705882 24.1 24 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.27500231174989e-10 2.12982124317111e-09 1.51240233548642 0.528925619834711 24.1 24 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.27500231174989e-10 2.12982124317111e-09 1.51240233548642 0.528925619834711 24.1 24 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000524295436280046 0.00154786806188072 1.50912021236253 0.527777777777778 24.1 24 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.26855902193245e-74 6.0171982940329e-72 1.50554240247073 0.526526526526527 24.1 24 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0115700040018089 0.0254075859484168 1.50493982396264 0.526315789473684 24.1 24 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0115700040018089 0.0254075859484168 1.50493982396264 0.526315789473684 24.1 24 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0115700040018089 0.0254075859484168 1.50493982396264 0.526315789473684 24.1 24 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.67443690100686e-15 5.6801846419892e-14 1.50415600113766 0.526041666666667 24.1 24 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 4.63770785631544e-07 2.42627142630032e-06 1.50301041393192 0.525641025641026 24.1 24 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00854677693001604 0.0192133705709523 1.49777344384853 0.523809523809524 24.1 24 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00854677693001604 0.0192133705709523 1.49777344384853 0.523809523809524 24.1 24 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00854677693001604 0.0192133705709523 1.49777344384853 0.523809523809524 24.1 24 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.74791094762345e-09 2.64023627646939e-08 1.49527507279957 0.522935779816514 24.1 24 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000168503085993411 0.000571759999614143 1.49467887061744 0.522727272727273 24.1 24 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000168503085993411 0.000571759999614143 1.49467887061744 0.522727272727273 24.1 24 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 7.23750729121831e-05 0.000262728899882746 1.48688054607509 0.52 24.1 24 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00349868612843447 0.00870527268323901 1.48264441916319 0.518518518518518 24.1 24 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00349868612843447 0.00870527268323901 1.48264441916319 0.518518518518518 24.1 24 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.02277806949666e-05 4.38377467739082e-05 1.4743707337884 0.515625 24.1 24 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.09951299541611e-11 1.27460647123763e-10 1.46635162334821 0.512820512820513 24.1 24 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 8.44224141361439e-07 4.2904676898476e-06 1.4645633896612 0.51219512195122 24.1 24 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.70379306978899e-33 4.78106967022123e-31 1.45875163017842 0.510162601626016 24.1 24 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.23041315563733e-06 1.05795930682397e-05 1.44779021039444 0.506329113924051 24.1 24 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.69072301239519e-06 8.21125886224696e-06 1.44734336156407 0.506172839506173 24.1 24 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.28190623004853e-06 6.35593228348106e-06 1.44691804761709 0.506024096385542 24.1 24 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 9.72146487838038e-07 4.83693864403331e-06 1.44651274844409 0.505882352941176 24.1 24 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 9.72146487838038e-07 4.83693864403331e-06 1.44651274844409 0.505882352941176 24.1 24 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.80551156974172e-11 4.13377325476525e-10 1.43868461158692 0.50314465408805 24.1 24 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.11409078205065e-28 1.50417559142904e-26 1.43610401138677 0.502242152466368 24.1 24 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.11138147563601e-07 1.19062603896577e-06 1.42969283276451 0.5 24.1 24 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00221519330113284 0.00582665446859895 1.42969283276451 0.5 24.1 24 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00534528581205995 0.0126561426132468 1.42969283276451 0.5 24.1 24 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.15052101624774e-12 2.63809603975908e-11 1.42969283276451 0.5 24.1 24 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.45818828630626e-06 7.20486781740908e-06 1.42969283276451 0.5 24.1 24 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.01767786082999e-05 4.37509243492772e-05 1.42969283276451 0.5 24.1 24 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000393994638742701 0.00121617000201923 1.42969283276451 0.5 24.1 24 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000393994638742701 0.00121617000201923 1.42969283276451 0.5 24.1 24 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0071965608458649 0.01633286456725 1.42969283276451 0.5 24.1 24 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00971181297379464 0.0214928613712438 1.42969283276451 0.5 24.1 24 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0178413874233743 0.0364067097591004 1.42969283276451 0.5 24.1 24 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0178413874233743 0.0364067097591004 1.42969283276451 0.5 24.1 24 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0243147012793146 0.047988654536012 1.42969283276451 0.5 24.1 24 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0243147012793146 0.047988654536012 1.42969283276451 0.5 24.1 24 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0243147012793146 0.047988654536012 1.42969283276451 0.5 24.1 24 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0332928627280945 0.0639348767369479 1.42969283276451 0.5 24.1 24 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0636311023890666 0.112202055389891 1.42969283276451 0.5 24.1 24 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0636311023890666 0.112202055389891 1.42969283276451 0.5 24.1 24 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0636311023890666 0.112202055389891 1.42969283276451 0.5 24.1 24 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0891884869296095 0.149664170873625 1.42969283276451 0.5 24.1 24 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0891884869296095 0.149664170873625 1.42969283276451 0.5 24.1 24 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0891884869296095 0.149664170873625 1.42969283276451 0.5 24.1 24 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0891884869296095 0.149664170873625 1.42969283276451 0.5 24.1 24 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0891884869296095 0.149664170873625 1.42969283276451 0.5 24.1 24 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.45663368112466e-10 1.41971899194547e-09 1.42058650898894 0.496815286624204 24.1 24 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.79128245824416e-13 2.83221659786827e-12 1.4160767105477 0.495238095238095 24.1 24 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 4.60868255862039e-05 0.000171679457615623 1.40769755841428 0.492307692307692 24.1 24 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.19480509126436e-11 1.37113519747515e-10 1.40625524534214 0.491803278688525 24.1 24 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 8.07282466653338e-05 0.000290826063303215 1.40625524534214 0.491803278688525 24.1 24 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 5.67107066907281e-08 3.50866676612635e-07 1.39424590302654 0.487603305785124 24.1 24 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.67258910071536e-05 6.9797486519588e-05 1.39206933716544 0.486842105263158 24.1 24 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 5.09357842463749e-05 0.000189247052173868 1.38764304356555 0.485294117647059 24.1 24 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.0244647376657e-13 1.73549204964083e-12 1.38674068757416 0.484978540772532 24.1 24 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 6.2507286153503e-08 3.80119094856559e-07 1.38357370912694 0.483870967741935 24.1 24 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00588216267000285 0.0136324388915538 1.38357370912694 0.483870967741935 24.1 24 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00789981408181613 0.0178719164362867 1.38039307991056 0.482758620689655 24.1 24 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00789981408181613 0.0178719164362867 1.38039307991056 0.482758620689655 24.1 24 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0106303016549074 0.0234525879921446 1.37674124636582 0.481481481481481 24.1 24 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0106303016549074 0.0234525879921446 1.37674124636582 0.481481481481481 24.1 24 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000481104222970421 0.00144778349152599 1.37470464688895 0.480769230769231 24.1 24 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00112659943734307 0.00318085515741903 1.36753227481822 0.478260869565217 24.1 24 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 3.65134799770132e-11 3.99682169286845e-10 1.36437691654684 0.477157360406091 24.1 24 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00265615964396287 0.00693525719882416 1.35820819112628 0.475 24.1 24 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.30722294490109e-39 9.97242027843806e-37 1.35463853552591 0.473751600512164 24.1 24 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 9.9406131904668e-09 6.70402491470818e-08 1.35444584156637 0.473684210526316 24.1 24 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.000519593710156906 0.00154551207918789 1.35170958734099 0.472727272727273 24.1 24 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.13726152485002e-07 1.69103149615969e-06 1.34832820000555 0.471544715447154 24.1 24 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00120935342379418 0.00338096251878019 1.34216061851362 0.469387755102041 24.1 24 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00845498775547371 0.0190975358349827 1.34033703071672 0.46875 24.1 24 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0672232513159742 0.115809547969287 1.33437997724687 0.466666666666667 24.1 24 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00282932607349395 0.0072805262252837 1.32994682117628 0.465116279069767 24.1 24 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.29909998890989e-07 7.57630854188024e-07 1.32757191613847 0.464285714285714 24.1 24 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.29909998890989e-07 7.57630854188024e-07 1.32757191613847 0.464285714285714 24.1 24 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.6053844701234e-12 2.00391412367157e-11 1.32757191613847 0.464285714285714 24.1 24 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.6053844701234e-12 2.00391412367157e-11 1.32757191613847 0.464285714285714 24.1 24 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.6053844701234e-12 2.00391412367157e-11 1.32757191613847 0.464285714285714 24.1 24 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0204566367110875 0.0415260970611663 1.31971646101339 0.461538461538462 24.1 24 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.092993567276128 0.154410555698868 1.31971646101339 0.461538461538462 24.1 24 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.092993567276128 0.154410555698868 1.31971646101339 0.461538461538462 24.1 24 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.092993567276128 0.154410555698868 1.31971646101339 0.461538461538462 24.1 24 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.092993567276128 0.154410555698868 1.31971646101339 0.461538461538462 24.1 24 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.092993567276128 0.154410555698868 1.31971646101339 0.461538461538462 24.1 24 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.35769215892898e-07 1.29038305467536e-06 1.3165516733371 0.460431654676259 24.1 24 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00020458853323205 0.000651296382078762 1.31055176336746 0.458333333333333 24.1 24 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0275703774680747 0.054263688986266 1.31055176336746 0.458333333333333 24.1 24 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00134320593640764 0.00368281704722171 1.29972075705864 0.454545454545455 24.1 24 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00393861078982462 0.00962997105484612 1.29972075705864 0.454545454545455 24.1 24 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.129749290254274 0.206063883964098 1.29972075705864 0.454545454545455 24.1 24 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.129749290254274 0.206063883964098 1.29972075705864 0.454545454545455 24.1 24 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.129749290254274 0.206063883964098 1.29972075705864 0.454545454545455 24.1 24 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.129749290254274 0.206063883964098 1.29972075705864 0.454545454545455 24.1 24 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0118446646466061 0.0259706591558096 1.29972075705864 0.454545454545455 24.1 24 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.01440107035734e-27 2.72023463005643e-25 1.29850795386387 0.454121306376361 24.1 24 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 7.58594122426545e-08 4.55476555364124e-07 1.29649163716533 0.453416149068323 24.1 24 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 9.89042589219179e-08 5.8398655786676e-07 1.29481615042823 0.452830188679245 24.1 24 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 9.89042589219179e-08 5.8398655786676e-07 1.29481615042823 0.452830188679245 24.1 24 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.68050398674663e-07 9.68160798842288e-07 1.29133546185181 0.451612903225806 24.1 24 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 1.03224111853909e-07 6.06974839537654e-07 1.28848860236801 0.450617283950617 24.1 24 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0504660081610021 0.093628591412133 1.28672354948805 0.45 24.1 24 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0504660081610021 0.093628591412133 1.28672354948805 0.45 24.1 24 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0504660081610021 0.093628591412133 1.28672354948805 0.45 24.1 24 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0504660081610021 0.093628591412133 1.28672354948805 0.45 24.1 24 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.16258688664885e-15 2.54517098415587e-14 1.28442992462266 0.449197860962567 24.1 24 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0211507018611838 0.0428738586160463 1.28179357420266 0.448275862068966 24.1 24 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 1.3976306165472e-07 8.11766680549657e-07 1.28058376431667 0.447852760736196 24.1 24 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00918844088296426 0.0206232671552968 1.27919885036824 0.447368421052632 24.1 24 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0685995492982164 0.117752905490183 1.27083807356845 0.444444444444444 24.1 24 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0685995492982164 0.117752905490183 1.27083807356845 0.444444444444444 24.1 24 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0283177047560316 0.0554279145362215 1.27083807356845 0.444444444444444 24.1 24 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0283177047560316 0.0554279145362215 1.27083807356845 0.444444444444444 24.1 24 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0283177047560316 0.0554279145362215 1.27083807356845 0.444444444444444 24.1 24 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.65849511940555e-09 1.21027618200723e-08 1.26941336720795 0.443946188340807 24.1 24 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.71843621111714e-21 6.98667065262769e-20 1.2619355301459 0.441330998248686 24.1 24 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0162076598189363 0.0343206844082535 1.26149367596868 0.441176470588235 24.1 24 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 6.73504348437277e-06 2.96717240813079e-05 1.26083147456397 0.440944881889764 24.1 24 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00188583912422518 0.00503480126411338 1.26006825938567 0.440677966101695 24.1 24 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 6.62676860359632e-05 0.00024117370135339 1.25812969283276 0.44 24.1 24 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0379683441458432 0.072522085529577 1.25812969283276 0.44 24.1 24 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.49754638880203e-06 1.16524869221813e-05 1.25731851959432 0.439716312056738 24.1 24 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.021545567654546 0.0434268311224065 1.25098122866894 0.4375 24.1 24 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.021545567654546 0.0434268311224065 1.25098122866894 0.4375 24.1 24 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0936135535509917 0.154717870735263 1.25098122866894 0.4375 24.1 24 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0936135535509917 0.154717870735263 1.25098122866894 0.4375 24.1 24 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0936135535509917 0.154717870735263 1.25098122866894 0.4375 24.1 24 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0936135535509917 0.154717870735263 1.25098122866894 0.4375 24.1 24 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00324534629245688 0.0081305066446587 1.2477319267763 0.436363636363636 24.1 24 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 8.50966405786346e-54 2.01820865905662e-51 1.24602022222859 0.435765009683667 24.1 24 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0509894880663517 0.0942312227511928 1.24321115892566 0.434782608695652 24.1 24 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0509894880663517 0.0942312227511928 1.24321115892566 0.434782608695652 24.1 24 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 4.38606697159294e-06 1.98769850336839e-05 1.2397336451944 0.433566433566434 24.1 24 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 2.10038521064788e-06 9.99614767475561e-06 1.23599251348673 0.432258064516129 24.1 24 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000534558807389696 0.00157490099982513 1.23553701596933 0.432098765432099 24.1 24 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.038147996784024 0.0727675595491503 1.22545099951243 0.428571428571429 24.1 24 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.128348166513188 0.204752736489088 1.22545099951243 0.428571428571429 24.1 24 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.128348166513188 0.204752736489088 1.22545099951243 0.428571428571429 24.1 24 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.128348166513188 0.204752736489088 1.22545099951243 0.428571428571429 24.1 24 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.128348166513188 0.204752736489088 1.22545099951243 0.428571428571429 24.1 24 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.128348166513188 0.204752736489088 1.22545099951243 0.428571428571429 24.1 24 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.128348166513188 0.204752736489088 1.22545099951243 0.428571428571429 24.1 24 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.128348166513188 0.204752736489088 1.22545099951243 0.428571428571429 24.1 24 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 3.02019560948265e-07 1.63412104649955e-06 1.22119596131968 0.427083333333333 24.1 24 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.63053903040837e-06 1.6505613547192e-05 1.21523890784983 0.425 24.1 24 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0286936014498702 0.0560865314054468 1.21307270658806 0.424242424242424 24.1 24 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0508102629313306 0.0941445366553171 1.20974008926227 0.423076923076923 24.1 24 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 1.62692896620331e-05 6.81124141285583e-05 1.20819112627986 0.422535211267606 24.1 24 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 2.09283525449012e-05 8.36546226724564e-05 1.20502681618723 0.421428571428571 24.1 24 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0216772696995839 0.0436304876697425 1.20395185917011 0.421052631578947 24.1 24 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.092464727821232 0.154410555698868 1.20395185917011 0.421052631578947 24.1 24 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.092464727821232 0.154410555698868 1.20395185917011 0.421052631578947 24.1 24 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.092464727821232 0.154410555698868 1.20395185917011 0.421052631578947 24.1 24 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000199626023654347 0.000651296382078762 1.20254537335332 0.420560747663551 24.1 24 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0379341474171051 0.072522085529577 1.19909721457668 0.419354838709677 24.1 24 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0379341474171051 0.072522085529577 1.19909721457668 0.419354838709677 24.1 24 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 3.45756499811893e-05 0.000134797671022554 1.19841899217025 0.419117647058824 24.1 24 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.012500784933646 0.0271997201232085 1.19141069397042 0.416666666666667 24.1 24 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0677174242079782 0.116519824241781 1.19141069397042 0.416666666666667 24.1 24 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.176976567300851 0.274034445341796 1.19141069397042 0.416666666666667 24.1 24 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.176976567300851 0.274034445341796 1.19141069397042 0.416666666666667 24.1 24 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.176976567300851 0.274034445341796 1.19141069397042 0.416666666666667 24.1 24 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 4.43781920840074e-05 0.000168400446228113 1.18967140828579 0.416058394160584 24.1 24 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 4.43781920840074e-05 0.000168400446228113 1.18967140828579 0.416058394160584 24.1 24 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.00953233852281075 0.021194558934312 1.18691480455921 0.415094339622642 24.1 24 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00331305708922539 0.00828555402103292 1.18460263286202 0.414285714285714 24.1 24 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0281156237561359 0.0552604041505267 1.17308129867857 0.41025641025641 24.1 24 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00115848119929307 0.00326439355761194 1.16835113215164 0.408602150537634 24.1 24 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00250075409464964 0.00654149462626184 1.16493490077108 0.407407407407407 24.1 24 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0662738966768486 0.115791847731841 1.16493490077108 0.407407407407407 24.1 24 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0491473862020139 0.091660197333507 1.16162542662116 0.40625 24.1 24 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00189992877831957 0.00506291882312501 1.15660543774207 0.404494382022472 24.1 24 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00109425011515435 0.00309566185658974 1.1437542662116 0.4 24.1 24 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0204062849094823 0.041483062037419 1.1437542662116 0.4 24.1 24 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0875501442494012 0.147786305180187 1.1437542662116 0.4 24.1 24 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0875501442494012 0.147786305180187 1.1437542662116 0.4 24.1 24 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0875501442494012 0.147786305180187 1.1437542662116 0.4 24.1 24 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.035868890737407 0.0687889912659436 1.1437542662116 0.4 24.1 24 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0644702668233974 0.113541076348632 1.1437542662116 0.4 24.1 24 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.120463874261386 0.194795560311309 1.1437542662116 0.4 24.1 24 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.120463874261386 0.194795560311309 1.1437542662116 0.4 24.1 24 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.169098109977997 0.262692806221277 1.1437542662116 0.4 24.1 24 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00304215498142725 0.00779204841413135 1.13725566242631 0.397727272727273 24.1 24 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0624423462909073 0.110516739766121 1.12642465611749 0.393939393939394 24.1 24 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0624423462909073 0.110516739766121 1.12642465611749 0.393939393939394 24.1 24 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0624423462909073 0.110516739766121 1.12642465611749 0.393939393939394 24.1 24 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00368965222160575 0.00903679020885538 1.11889004303309 0.391304347826087 24.1 24 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.115571399367716 0.18730991036476 1.11889004303309 0.391304347826087 24.1 24 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.115571399367716 0.18730991036476 1.11889004303309 0.391304347826087 24.1 24 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0248135820174974 0.0489054393502754 1.11198331437239 0.388888888888889 24.1 24 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.060282647084595 0.107093891137801 1.11198331437239 0.388888888888889 24.1 24 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.160728974665559 0.254130367721212 1.11198331437239 0.388888888888889 24.1 24 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.000249646915959467 0.000785945932323721 1.11097150061955 0.388535031847134 24.1 24 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00607627308807781 0.013946026781185 1.11011443485244 0.388235294117647 24.1 24 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00607627308807781 0.013946026781185 1.11011443485244 0.388235294117647 24.1 24 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00607627308807781 0.013946026781185 1.11011443485244 0.388235294117647 24.1 24 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00607627308807781 0.013946026781185 1.11011443485244 0.388235294117647 24.1 24 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00607627308807781 0.013946026781185 1.11011443485244 0.388235294117647 24.1 24 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00590303514675787 0.0136585675021731 1.10476264349984 0.386363636363636 24.1 24 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0580551624068901 0.103265620131256 1.09976371751116 0.384615384615385 24.1 24 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0580551624068901 0.103265620131256 1.09976371751116 0.384615384615385 24.1 24 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.110512570073196 0.181592825882399 1.09976371751116 0.384615384615385 24.1 24 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.110512570073196 0.181592825882399 1.09976371751116 0.384615384615385 24.1 24 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.229465942316303 0.345169171158667 1.09976371751116 0.384615384615385 24.1 24 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.229465942316303 0.345169171158667 1.09976371751116 0.384615384615385 24.1 24 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.229465942316303 0.345169171158667 1.09976371751116 0.384615384615385 24.1 24 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.229465942316303 0.345169171158667 1.09976371751116 0.384615384615385 24.1 24 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0779238517238591 0.133276010820975 1.09329451917286 0.382352941176471 24.1 24 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00310477262882113 0.00779204841413135 1.09176543592926 0.381818181818182 24.1 24 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0558046143927553 0.100473190598281 1.08928977734438 0.380952380952381 24.1 24 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0746216356737225 0.127935647667117 1.08192971128125 0.378378378378378 24.1 24 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0535624220987287 0.0987296977286151 1.08021236253318 0.377777777777778 24.1 24 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0513506566632297 0.0947755958907599 1.07226962457338 0.375 24.1 24 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.2143888438342 0.324203320697202 1.07226962457338 0.375 24.1 24 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0956533503180846 0.157905704759437 1.06205753291078 0.371428571428571 24.1 24 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.187856995928925 0.284686374022215 1.03977660564691 0.363636363636364 24.1 24 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.12221492553768 0.197402768490487 1.03977660564691 0.363636363636364 24.1 24 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0489278712752933 0.0913705522634415 1.02759172354949 0.359375 24.1 24 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 6.9485956323544e-07 3.55678114562601e-06 1.0224469955528 0.357575757575758 24.1 24 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.16545882510635 0.259113415120079 1.02120916626036 0.357142857142857 24.1 24 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.285642484429144 0.404849855918996 1.02120916626036 0.357142857142857 24.1 24 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.285642484429144 0.404849855918996 1.02120916626036 0.357142857142857 24.1 24 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.155546359835729 0.24675860651755 1.01462072002642 0.354838709677419 24.1 24 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.263200468761683 0.381788243677752 1.00919494077494 0.352941176470588 24.1 24 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.263200468761683 0.381788243677752 1.00919494077494 0.352941176470588 24.1 24 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.109326401053472 0.180059570253577 0.992031761510065 0.346938775510204 24.1 24 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.210970279619164 0.319373093508586 0.989787345760042 0.346153846153846 24.1 24 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00138053021072933 0.0037778740189766 0.986768386535502 0.345098039215686 24.1 24 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.156178546936795 0.247210314005627 0.953128555176337 0.333333333333333 24.1 24 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.156178546936795 0.247210314005627 0.953128555176337 0.333333333333333 24.1 24 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.267472078910575 0.386408901817003 0.953128555176337 0.333333333333333 24.1 24 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.215478940860871 0.325505873508513 0.953128555176337 0.333333333333333 24.1 24 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.230975169604798 0.347072509342795 0.953128555176337 0.333333333333333 24.1 24 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.314436215809745 0.441700626946957 0.953128555176337 0.333333333333333 24.1 24 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.314436215809745 0.441700626946957 0.953128555176337 0.333333333333333 24.1 24 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.248187759863812 0.369425922893519 0.953128555176337 0.333333333333333 24.1 24 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.248187759863812 0.369425922893519 0.953128555176337 0.333333333333333 24.1 24 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0762402171825582 0.130553344224766 0.942988889695737 0.329787234042553 24.1 24 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0190351074919075 0.0387510128197201 0.942824462687944 0.32972972972973 24.1 24 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.105649715059608 0.17420572946677 0.940587389976648 0.328947368421053 24.1 24 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0537644587904269 0.0989739002054043 0.937503496894757 0.327868852459016 24.1 24 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.248529276759661 0.369547712464992 0.925095362377033 0.323529411764706 24.1 24 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.266893650447211 0.385965106286973 0.922382472751294 0.32258064516129 24.1 24 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.287375150012083 0.406495863287469 0.919088249634325 0.321428571428571 24.1 24 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.287375150012083 0.406495863287469 0.919088249634325 0.321428571428571 24.1 24 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0437499423909846 0.0818083679663221 0.914338439558695 0.319767441860465 24.1 24 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.366999183725896 0.510498375798583 0.902963894377582 0.315789473684211 24.1 24 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0922913281207624 0.154410555698868 0.900593910402838 0.31496062992126 24.1 24 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.243874697167634 0.366069297541712 0.893558020477816 0.3125 24.1 24 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.402790047936771 0.547440533155707 0.893558020477816 0.3125 24.1 24 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.402790047936771 0.547440533155707 0.893558020477816 0.3125 24.1 24 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.402790047936771 0.547440533155707 0.893558020477816 0.3125 24.1 24 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.328025015040504 0.459881375766145 0.887395551371072 0.310344827586207 24.1 24 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.354627549641147 0.49377201872735 0.879810974008926 0.307692307692308 24.1 24 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.283857389812593 0.403122820063194 0.863210766952154 0.30188679245283 24.1 24 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.419853276091984 0.568459763919023 0.857815699658703 0.3 24.1 24 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.419853276091984 0.568459763919023 0.857815699658703 0.3 24.1 24 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.419853276091984 0.568459763919023 0.857815699658703 0.3 24.1 24 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.369617805941521 0.513137695468082 0.857815699658703 0.3 24.1 24 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.322258252707753 0.452242104145102 0.851731900370343 0.297872340425532 24.1 24 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.460952372593058 0.6051062972324 0.840995783979121 0.294117647058824 24.1 24 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.460952372593058 0.6051062972324 0.840995783979121 0.294117647058824 24.1 24 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.460952372593058 0.6051062972324 0.840995783979121 0.294117647058824 24.1 24 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.265744418504034 0.384694107356298 0.840995783979121 0.294117647058824 24.1 24 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.265744418504034 0.384694107356298 0.840995783979121 0.294117647058824 24.1 24 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.000150149178503197 0.000518597769441866 0.839683010072422 0.293658536585366 24.1 24 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.184770985721808 0.280308222475622 0.836893365520686 0.292682926829268 24.1 24 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.367677687736991 0.510942724267322 0.836893365520686 0.292682926829268 24.1 24 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.433259921998902 0.581631008494752 0.833987485779295 0.291666666666667 24.1 24 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.433259921998902 0.581631008494752 0.833987485779295 0.291666666666667 24.1 24 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.295770140830199 0.417955223834532 0.8324793709768 0.291139240506329 24.1 24 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.444271964519412 0.593797214559885 0.816967333008289 0.285714285714286 24.1 24 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.403510174914132 0.547895972235505 0.816967333008289 0.285714285714286 24.1 24 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.472067166301051 0.619125878015111 0.816967333008289 0.285714285714286 24.1 24 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.395829766086431 0.5395265872998 0.809260094017644 0.283018867924528 24.1 24 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.481028936721857 0.630298505483611 0.800627986348123 0.28 24.1 24 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.51730474058664 0.663175356625936 0.794273795980281 0.277777777777778 24.1 24 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.522842125138381 0.669068654740932 0.779832454235185 0.272727272727273 24.1 24 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.522842125138381 0.669068654740932 0.779832454235185 0.272727272727273 24.1 24 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.495064821725042 0.642771205579137 0.779832454235185 0.272727272727273 24.1 24 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.495064821725042 0.642771205579137 0.779832454235185 0.272727272727273 24.1 24 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.500813474320433 0.645363200767121 0.772806936629462 0.27027027027027 24.1 24 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.527597868804223 0.673942340492289 0.76983460225781 0.269230769230769 24.1 24 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.526221376252324 0.672787977005442 0.750002797515806 0.262295081967213 24.1 24 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.545361130271013 0.696007971637355 0.745926695355394 0.260869565217391 24.1 24 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.572451616754641 0.725666059796121 0.741322209581595 0.259259259259259 24.1 24 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.554271450738727 0.70674576559248 0.734942500376934 0.257028112449799 24.1 24 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.587911640596159 0.736734551475932 0.724914675767918 0.253521126760563 24.1 24 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.640417960182483 0.793828185835952 0.704486323391205 0.246376811594203 24.1 24 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.684873906079555 0.841602390631439 0.692272319022813 0.242105263157895 24.1 24 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.668095756948611 0.822405071053524 0.69178685456347 0.241935483870968 24.1 24 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.688075691340872 0.84473897433933 0.687700349937357 0.240506329113924 24.1 24 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.745651606854146 0.894656185964123 0.65625244782633 0.229508196721311 24.1 24 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.727956319153346 0.876380577119468 0.645667730925906 0.225806451612903 24.1 24 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.886308078381066 1 0.645667730925906 0.225806451612903 24.1 24 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.890916439299495 1 0.604870044631137 0.211538461538462 24.1 24 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.987642459378181 1 0.582089224768406 0.203571428571429 24.1 24 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.827589670373963 0.974077833699048 0.571877133105802 0.2 24.1 24 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.992640854359928 1 0.56066385598608 0.196078431372549 24.1 24 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999626432956044 1 0.537977199957778 0.188144329896907 24.1 24 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.965616564663489 1 0.530607649273425 0.185567010309278 24.1 24 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.896268155551246 1 0.526728938386923 0.184210526315789 24.1 24 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.919006058728674 1 0.525193285505328 0.183673469387755 24.1 24 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.973148937845213 1 0.519888302823456 0.181818181818182 24.1 24 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.910971385929758 1 0.513223068171874 0.179487179487179 24.1 24 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.907359694610061 1 0.504597470387472 0.176470588235294 24.1 24 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.92142269826958 1 0.490180399804973 0.171428571428571 24.1 24 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.935062604522467 1 0.488187796553733 0.170731707317073 24.1 24 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999033592219826 1 0.476564277588168 0.166666666666667 24.1 24 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.919846184148031 1 0.476564277588168 0.166666666666667 24.1 24 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.436950622272275 0.152812762384551 24.1 24 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999877618494184 1 0.422409246044058 0.147727272727273 24.1 24 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.978579020882801 1 0.386403468314731 0.135135135135135 24.1 24 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.35936221293719 0.125678119349005 24.1 24 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.992882169815939 1 0.357423208191126 0.125 24.1 24 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.996417320127227 1 0.351152625591282 0.12280701754386 24.1 24 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.993751803041019 1 0.332486705294071 0.116279069767442 24.1 24 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.998937393503896 1 0.317709518392112 0.111111111111111 24.1 24 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999959988920622 1 0.317709518392112 0.111111111111111 24.1 24 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999956163708293 1 0.285938566552901 0.1 24.1 24 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 4.15058325411457e-09 2.70930273880965e-08 1.23389964440932 1 24.2 24 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 6.45941445404311e-05 0.000208429631929781 1.23389964440932 1 24.2 24 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 6.45941445404311e-05 0.000208429631929781 1.23389964440932 1 24.2 24 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 6.45941445404311e-05 0.000208429631929781 1.23389964440932 1 24.2 24 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 6.45941445404311e-05 0.000208429631929781 1.23389964440932 1 24.2 24 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 6.45941445404311e-05 0.000208429631929781 1.23389964440932 1 24.2 24 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 6.45941445404311e-05 0.000208429631929781 1.23389964440932 1 24.2 24 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00804231462405972 0.0161641436582443 1.23389964440932 1 24.2 24 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 2.58871928109611e-06 1.05854814281602e-05 1.23389964440932 1 24.2 24 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 2.58871928109611e-06 1.05854814281602e-05 1.23389964440932 1 24.2 24 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 5.78609729765263e-06 2.22530174447559e-05 1.23389964440932 1 24.2 24 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 5.78609729765263e-06 2.22530174447559e-05 1.23389964440932 1 24.2 24 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 1.29321486530056e-05 4.77985650213687e-05 1.23389964440932 1 24.2 24 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 2.89027939743012e-05 0.000101552285988717 1.23389964440932 1 24.2 24 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000720872148213292 0.00186849010365668 1.23389964440932 1 24.2 24 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.000720872148213292 0.00186849010365668 1.23389964440932 1 24.2 24 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.000720872148213292 0.00186849010365668 1.23389964440932 1 24.2 24 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.000720872148213292 0.00186849010365668 1.23389964440932 1 24.2 24 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000720872148213292 0.00186849010365668 1.23389964440932 1 24.2 24 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00161082486353946 0.00388509115392654 1.23389964440932 1 24.2 24 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00359933769659846 0.00786767671622061 1.23389964440932 1 24.2 24 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00359933769659846 0.00786767671622061 1.23389964440932 1 24.2 24 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00359933769659846 0.00786767671622061 1.23389964440932 1 24.2 24 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00359933769659846 0.00786767671622061 1.23389964440932 1 24.2 24 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00359933769659846 0.00786767671622061 1.23389964440932 1 24.2 24 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00359933769659846 0.00786767671622061 1.23389964440932 1 24.2 24 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00359933769659846 0.00786767671622061 1.23389964440932 1 24.2 24 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 2.07466532026085e-08 1.20010111818341e-07 1.23389964440932 1 24.2 24 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 4.63813902755052e-08 2.43545086206804e-07 1.23389964440932 1 24.2 24 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 4.63813902755052e-08 2.43545086206804e-07 1.23389964440932 1 24.2 24 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000144354611123535 0.000436128687109958 1.23389964440932 1 24.2 24 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000144354611123535 0.000436128687109958 1.23389964440932 1 24.2 24 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000144354611123535 0.000436128687109958 1.23389964440932 1 24.2 24 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000144354611123535 0.000436128687109958 1.23389964440932 1 24.2 24 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.000322591083397704 0.000894828677728913 1.23389964440932 1 24.2 24 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000322591083397704 0.000894828677728913 1.23389964440932 1 24.2 24 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000322591083397704 0.000894828677728913 1.23389964440932 1 24.2 24 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.000322591083397704 0.000894828677728913 1.23389964440932 1 24.2 24 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.000322591083397704 0.000894828677728913 1.23389964440932 1 24.2 24 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000322591083397704 0.000894828677728913 1.23389964440932 1 24.2 24 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.000322591083397704 0.000894828677728913 1.23389964440932 1 24.2 24 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000322591083397704 0.000894828677728913 1.23389964440932 1 24.2 24 2 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0179689921436981 0.0323669314183322 1.23389964440932 1 24.2 24 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.24100911252285e-10 1.06382889585543e-09 1.19650874609389 0.96969696969697 24.2 24 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 5.92115595483438e-08 3.05282787091642e-07 1.18454365863295 0.96 24.2 24 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 5.92115595483438e-08 3.05282787091642e-07 1.18454365863295 0.96 24.2 24 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.01670766382302e-14 4.56004467796725e-13 1.1824871592256 0.958333333333333 24.2 24 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.27250701725022e-07 6.07643451525861e-07 1.1824871592256 0.958333333333333 24.2 24 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 2.73018416804476e-07 1.25729840489569e-06 1.18025183378283 0.956521739130435 24.2 24 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.2497958905149e-06 5.29303438155567e-06 1.17514251848507 0.952380952380952 24.2 24 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.6656754467561e-06 1.07457681607194e-05 1.17220466218886 0.95 24.2 24 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 2.6656754467561e-06 1.07457681607194e-05 1.17220466218886 0.95 24.2 24 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 2.6656754467561e-06 1.07457681607194e-05 1.17220466218886 0.95 24.2 24 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 2.6656754467561e-06 1.07457681607194e-05 1.17220466218886 0.95 24.2 24 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 2.6656754467561e-06 1.07457681607194e-05 1.17220466218886 0.95 24.2 24 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 5.67225386520684e-06 2.19337425276884e-05 1.16895755786147 0.947368421052632 24.2 24 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 1.20387171264853e-05 4.4612225184866e-05 1.16534966416436 0.944444444444444 24.2 24 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 2.5477676171118e-05 8.9739438592824e-05 1.16131731238525 0.941176470588235 24.2 24 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 2.5477676171118e-05 8.9739438592824e-05 1.16131731238525 0.941176470588235 24.2 24 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.5477676171118e-05 8.9739438592824e-05 1.16131731238525 0.941176470588235 24.2 24 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.37467675460003e-05 0.000182533771403242 1.15678091663374 0.9375 24.2 24 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.37467675460003e-05 0.000182533771403242 1.15678091663374 0.9375 24.2 24 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 5.37467675460003e-05 0.000182533771403242 1.15678091663374 0.9375 24.2 24 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 5.37467675460003e-05 0.000182533771403242 1.15678091663374 0.9375 24.2 24 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.33381584487764e-08 1.32188810053721e-07 1.15163966811537 0.933333333333333 24.2 24 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000112976867627947 0.000352557198760019 1.15163966811537 0.933333333333333 24.2 24 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000112976867627947 0.000352557198760019 1.15163966811537 0.933333333333333 24.2 24 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000112976867627947 0.000352557198760019 1.15163966811537 0.933333333333333 24.2 24 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000112976867627947 0.000352557198760019 1.15163966811537 0.933333333333333 24.2 24 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000236521183151144 0.000673139287248156 1.14576395552294 0.928571428571429 24.2 24 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000236521183151144 0.000673139287248156 1.14576395552294 0.928571428571429 24.2 24 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000236521183151144 0.000673139287248156 1.14576395552294 0.928571428571429 24.2 24 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 1.01753097091441e-10 8.93794180006918e-10 1.1436143045745 0.926829268292683 24.2 24 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 4.39634843725225e-07 1.97974804626897e-06 1.13898428714707 0.923076923076923 24.2 24 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000492890351333988 0.00130936411034294 1.13898428714707 0.923076923076923 24.2 24 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.000492890351333988 0.00130936411034294 1.13898428714707 0.923076923076923 24.2 24 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000492890351333988 0.00130936411034294 1.13898428714707 0.923076923076923 24.2 24 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000492890351333988 0.00130936411034294 1.13898428714707 0.923076923076923 24.2 24 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000492890351333988 0.00130936411034294 1.13898428714707 0.923076923076923 24.2 24 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000492890351333988 0.00130936411034294 1.13898428714707 0.923076923076923 24.2 24 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 9.05745515890624e-10 6.92944015651805e-09 1.13648651458754 0.921052631578947 24.2 24 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.95206897034658e-12 2.48017334357427e-11 1.13518767285658 0.92 24.2 24 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 9.09700836756824e-07 3.91088909578538e-06 1.13518767285658 0.92 24.2 24 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 9.09700836756824e-07 3.91088909578538e-06 1.13518767285658 0.92 24.2 24 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 9.09700836756824e-07 3.91088909578538e-06 1.13518767285658 0.92 24.2 24 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 9.09700836756824e-07 3.91088909578538e-06 1.13518767285658 0.92 24.2 24 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 9.09700836756824e-07 3.91088909578538e-06 1.13518767285658 0.92 24.2 24 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 4.49731612171481e-20 1.52373353361909e-18 1.13228437957562 0.917647058823529 24.2 24 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 4.49731612171481e-20 1.52373353361909e-18 1.13228437957562 0.917647058823529 24.2 24 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 4.49731612171481e-20 1.52373353361909e-18 1.13228437957562 0.917647058823529 24.2 24 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 1.87646328267847e-06 7.79792941173936e-06 1.13107467404188 0.916666666666667 24.2 24 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 1.87646328267847e-06 7.79792941173936e-06 1.13107467404188 0.916666666666667 24.2 24 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00102171974353768 0.00257784963662077 1.13107467404188 0.916666666666667 24.2 24 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00102171974353768 0.00257784963662077 1.13107467404188 0.916666666666667 24.2 24 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00102171974353768 0.00257784963662077 1.13107467404188 0.916666666666667 24.2 24 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00102171974353768 0.00257784963662077 1.13107467404188 0.916666666666667 24.2 24 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00102171974353768 0.00257784963662077 1.13107467404188 0.916666666666667 24.2 24 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 3.84976727654954e-09 2.53621242339352e-08 1.13107467404188 0.916666666666667 24.2 24 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.70115640184831e-11 1.66947969643458e-10 1.12888690871491 0.914893617021277 24.2 24 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 7.90925916744319e-09 5.02449812288913e-08 1.12813681774567 0.914285714285714 24.2 24 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 7.90925916744319e-09 5.02449812288913e-08 1.12813681774567 0.914285714285714 24.2 24 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 3.85748161482585e-06 1.524776760527e-05 1.12660402315634 0.91304347826087 24.2 24 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.62088450883478e-08 9.6912548574449e-08 1.12502614637321 0.911764705882353 24.2 24 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.62088450883478e-08 9.6912548574449e-08 1.12502614637321 0.911764705882353 24.2 24 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.47872512734173e-15 2.697725456676e-14 1.12340116879058 0.91044776119403 24.2 24 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0021049558061394 0.00478490752737439 1.12172694946302 0.909090909090909 24.2 24 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0021049558061394 0.00478490752737439 1.12172694946302 0.909090909090909 24.2 24 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0021049558061394 0.00478490752737439 1.12172694946302 0.909090909090909 24.2 24 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0021049558061394 0.00478490752737439 1.12172694946302 0.909090909090909 24.2 24 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0021049558061394 0.00478490752737439 1.12172694946302 0.909090909090909 24.2 24 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0021049558061394 0.00478490752737439 1.12172694946302 0.909090909090909 24.2 24 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0021049558061394 0.00478490752737439 1.12172694946302 0.909090909090909 24.2 24 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0021049558061394 0.00478490752737439 1.12172694946302 0.909090909090909 24.2 24 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.96965660042425e-10 2.41475505280212e-09 1.11911828213869 0.906976744186046 24.2 24 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.96965660042425e-10 2.41475505280212e-09 1.11911828213869 0.906976744186046 24.2 24 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 1.61165312310474e-05 5.85046529127052e-05 1.11638539256082 0.904761904761905 24.2 24 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 1.61165312310474e-05 5.85046529127052e-05 1.11638539256082 0.904761904761905 24.2 24 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 1.61165312310474e-05 5.85046529127052e-05 1.11638539256082 0.904761904761905 24.2 24 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.61165312310474e-05 5.85046529127052e-05 1.11638539256082 0.904761904761905 24.2 24 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.61165312310474e-05 5.85046529127052e-05 1.11638539256082 0.904761904761905 24.2 24 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.37221601384495e-07 6.53064678160991e-07 1.11449000140197 0.903225806451613 24.2 24 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.15830294824575e-20 8.30071647392891e-19 1.11449000140197 0.903225806451613 24.2 24 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.22452388709634e-09 9.17103942809521e-09 1.11351919129622 0.902439024390244 24.2 24 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.22452388709634e-09 9.17103942809521e-09 1.11351919129622 0.902439024390244 24.2 24 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 2.77970087656719e-07 1.27186956506595e-06 1.11050967996839 0.9 24.2 24 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 3.27314596312639e-05 0.000114439476794321 1.11050967996839 0.9 24.2 24 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00430540173155359 0.00918528735232498 1.11050967996839 0.9 24.2 24 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00430540173155359 0.00918528735232498 1.11050967996839 0.9 24.2 24 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00430540173155359 0.00918528735232498 1.11050967996839 0.9 24.2 24 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00430540173155359 0.00918528735232498 1.11050967996839 0.9 24.2 24 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00430540173155359 0.00918528735232498 1.11050967996839 0.9 24.2 24 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.00430540173155359 0.00918528735232498 1.11050967996839 0.9 24.2 24 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00430540173155359 0.00918528735232498 1.11050967996839 0.9 24.2 24 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 8.56890786083378e-13 1.10850508054241e-11 1.10625485360836 0.896551724137931 24.2 24 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 8.56890786083378e-13 1.10850508054241e-11 1.10625485360836 0.896551724137931 24.2 24 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 5.61180923694958e-07 2.49550142005602e-06 1.10625485360836 0.896551724137931 24.2 24 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 5.61180923694958e-07 2.49550142005602e-06 1.10625485360836 0.896551724137931 24.2 24 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 1.00606432320833e-08 6.30673802610332e-08 1.10401547131361 0.894736842105263 24.2 24 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 1.00606432320833e-08 6.30673802610332e-08 1.10401547131361 0.894736842105263 24.2 24 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 6.61536548473517e-05 0.000212978848071904 1.10401547131361 0.894736842105263 24.2 24 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.84962781446257e-10 1.57606010777259e-09 1.10263372479131 0.893617021276596 24.2 24 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.19271743256141e-16 1.19084282520742e-14 1.102283682339 0.893333333333333 24.2 24 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.19271743256141e-16 1.19084282520742e-14 1.102283682339 0.893333333333333 24.2 24 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.19271743256141e-16 1.19084282520742e-14 1.102283682339 0.893333333333333 24.2 24 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.19271743256141e-16 1.19084282520742e-14 1.102283682339 0.893333333333333 24.2 24 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.19271743256141e-16 1.19084282520742e-14 1.102283682339 0.893333333333333 24.2 24 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.01876408905552e-08 1.17253114233714e-07 1.10050508825696 0.891891891891892 24.2 24 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.01876408905552e-08 1.17253114233714e-07 1.10050508825696 0.891891891891892 24.2 24 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.49609191554004e-20 1.27562533225987e-18 1.0967996839194 0.888888888888889 24.2 24 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 4.03851942945923e-08 2.17682316216685e-07 1.0967996839194 0.888888888888889 24.2 24 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00013298934852818 0.000406102667286694 1.0967996839194 0.888888888888889 24.2 24 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00013298934852818 0.000406102667286694 1.0967996839194 0.888888888888889 24.2 24 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00013298934852818 0.000406102667286694 1.0967996839194 0.888888888888889 24.2 24 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.00873044658614885 0.0171121563251926 1.0967996839194 0.888888888888889 24.2 24 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.38147029924721e-11 1.41426779556027e-10 1.0967996839194 0.888888888888889 24.2 24 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.26194370128605e-06 9.32969822298565e-06 1.0967996839194 0.888888888888889 24.2 24 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.34459059991823e-21 6.37784141227882e-20 1.09551837587744 0.88785046728972 24.2 24 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.05863360613067e-20 4.4306930044822e-19 1.09152660851594 0.884615384615385 24.2 24 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 5.47529032526447e-11 4.86958633303209e-10 1.09152660851594 0.884615384615385 24.2 24 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 5.47529032526447e-11 4.86958633303209e-10 1.09152660851594 0.884615384615385 24.2 24 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.51354011666572e-06 1.76449658956465e-05 1.09152660851594 0.884615384615385 24.2 24 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 4.51354011666572e-06 1.76449658956465e-05 1.09152660851594 0.884615384615385 24.2 24 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.08617881368308e-10 9.42458812116474e-10 1.08873498036117 0.882352941176471 24.2 24 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 1.60037394386368e-07 7.49122408591454e-07 1.08873498036117 0.882352941176471 24.2 24 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.53502111067307e-25 2.01213401619511e-23 1.08433605114759 0.878787878787879 24.2 24 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.1498551019218e-08 7.11410352189009e-08 1.08342407801794 0.878048780487805 24.2 24 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.37397714622337e-24 7.51988261183023e-23 1.08203507278972 0.876923076923077 24.2 24 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 1.77246099398575e-05 6.33721606643649e-05 1.07966218885816 0.875 24.2 24 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 1.77246099398575e-05 6.33721606643649e-05 1.07966218885816 0.875 24.2 24 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 1.77246099398575e-05 6.33721606643649e-05 1.07966218885816 0.875 24.2 24 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.26524161099505e-08 1.30503595645585e-07 1.07966218885816 0.875 24.2 24 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 6.25093694482044e-07 2.76244822126692e-06 1.07966218885816 0.875 24.2 24 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 6.25093694482044e-07 2.76244822126692e-06 1.07966218885816 0.875 24.2 24 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000527587568201572 0.00138260977817834 1.07966218885816 0.875 24.2 24 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000527587568201572 0.00138260977817834 1.07966218885816 0.875 24.2 24 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000527587568201572 0.00138260977817834 1.07966218885816 0.875 24.2 24 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000527587568201572 0.00138260977817834 1.07966218885816 0.875 24.2 24 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000527587568201572 0.00138260977817834 1.07966218885816 0.875 24.2 24 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0175189275280114 0.0323669314183322 1.07966218885816 0.875 24.2 24 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.30353409724688e-15 5.87616127547788e-14 1.07770981600308 0.873417721518987 24.2 24 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.30353409724688e-15 5.87616127547788e-14 1.07770981600308 0.873417721518987 24.2 24 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.71677979201858e-20 1.01736253790591e-18 1.07541712127418 0.871559633027523 24.2 24 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 1.22802236999425e-06 5.21634576866213e-06 1.07468678706619 0.870967741935484 24.2 24 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 3.48550760594321e-05 0.000120385371923718 1.07295621252985 0.869565217391304 24.2 24 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.73774975537341e-37 9.58781790189636e-35 1.06937969182141 0.866666666666667 24.2 24 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00103955923405193 0.00260438871488714 1.06937969182141 0.866666666666667 24.2 24 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00103955923405193 0.00260438871488714 1.06937969182141 0.866666666666667 24.2 24 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00103955923405193 0.00260438871488714 1.06937969182141 0.866666666666667 24.2 24 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00103955923405193 0.00260438871488714 1.06937969182141 0.866666666666667 24.2 24 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 7.66186962476269e-19 2.3197532927739e-17 1.06779776920038 0.865384615384615 24.2 24 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 6.81504703462106e-05 0.0002179283579835 1.06564060198987 0.863636363636364 24.2 24 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 6.81504703462106e-05 0.0002179283579835 1.06564060198987 0.863636363636364 24.2 24 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 6.81504703462106e-05 0.0002179283579835 1.06564060198987 0.863636363636364 24.2 24 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.81445392887134e-13 2.50676499105235e-12 1.0648722958601 0.863013698630137 24.2 24 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 8.83242654157647e-10 6.83072987427354e-09 1.06454086968648 0.862745098039216 24.2 24 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 4.67676059316633e-06 1.81831429619554e-05 1.06370659000804 0.862068965517241 24.2 24 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 4.67676059316633e-06 1.81831429619554e-05 1.06370659000804 0.862068965517241 24.2 24 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 3.2943237439611e-07 1.49293716167409e-06 1.06252469379692 0.861111111111111 24.2 24 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 3.2943237439611e-07 1.49293716167409e-06 1.06252469379692 0.861111111111111 24.2 24 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.60559698017318e-14 3.98684355138327e-13 1.06209083316246 0.860759493670886 24.2 24 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.60559698017318e-14 3.98684355138327e-13 1.06209083316246 0.860759493670886 24.2 24 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.0790466202389e-17 2.84348766777769e-16 1.06115369419202 0.86 24.2 24 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.70989504028721e-09 1.27391656666424e-08 1.06115369419202 0.86 24.2 24 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 6.0627616266759e-29 5.07488811456459e-27 1.05970204755154 0.858823529411765 24.2 24 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.74140414754772e-15 6.57286185427211e-14 1.05970204755154 0.858823529411765 24.2 24 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.16971978759189e-28 8.76058556706977e-27 1.05867129254054 0.857988165680473 24.2 24 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.01108512069601e-17 9.6741934351702e-16 1.05762826663656 0.857142857142857 24.2 24 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.40987664682307e-10 1.99375259792397e-09 1.05762826663656 0.857142857142857 24.2 24 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 6.37077944852428e-07 2.80669323691952e-06 1.05762826663656 0.857142857142857 24.2 24 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 9.0605233989942e-06 3.41087957586475e-05 1.05762826663656 0.857142857142857 24.2 24 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 9.0605233989942e-06 3.41087957586475e-05 1.05762826663656 0.857142857142857 24.2 24 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.00203110536043106 0.00467680085419645 1.05762826663656 0.857142857142857 24.2 24 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0347001761888273 0.0591357493613188 1.05762826663656 0.857142857142857 24.2 24 2 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0347001761888273 0.0591357493613188 1.05762826663656 0.857142857142857 24.2 24 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0347001761888273 0.0591357493613188 1.05762826663656 0.857142857142857 24.2 24 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0347001761888273 0.0591357493613188 1.05762826663656 0.857142857142857 24.2 24 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0347001761888273 0.0591357493613188 1.05762826663656 0.857142857142857 24.2 24 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0347001761888273 0.0591357493613188 1.05762826663656 0.857142857142857 24.2 24 2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0347001761888273 0.0591357493613188 1.05762826663656 0.857142857142857 24.2 24 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0347001761888273 0.0591357493613188 1.05762826663656 0.857142857142857 24.2 24 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 4.55799517687449e-08 2.41116250434661e-07 1.05762826663656 0.857142857142857 24.2 24 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000132421030032562 0.000406102667286694 1.05762826663656 0.857142857142857 24.2 24 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.0331402526128e-15 1.9602114392907e-14 1.05566969577242 0.855555555555556 24.2 24 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.38626247291512e-14 2.32076646936261e-13 1.05550451509713 0.855421686746988 24.2 24 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.38626247291512e-14 2.32076646936261e-13 1.05550451509713 0.855421686746988 24.2 24 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.5152291612535e-12 2.81824495784546e-11 1.05507360898768 0.855072463768116 24.2 24 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.41691306410532e-69 1.54165345804437e-66 1.05431800602111 0.854460093896714 24.2 24 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 6.34874913017595e-09 4.06949099650468e-08 1.0539559462663 0.854166666666667 24.2 24 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 8.9462540935387e-21 3.85773320457744e-19 1.05332896473967 0.853658536585366 24.2 24 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 8.7716629139224e-08 4.44202004502191e-07 1.05332896473967 0.853658536585366 24.2 24 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 8.7716629139224e-08 4.44202004502191e-07 1.05332896473967 0.853658536585366 24.2 24 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 8.7716629139224e-08 4.44202004502191e-07 1.05332896473967 0.853658536585366 24.2 24 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 8.7716629139224e-08 4.44202004502191e-07 1.05332896473967 0.853658536585366 24.2 24 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 1.22666695533476e-06 5.21634576866213e-06 1.05244381434913 0.852941176470588 24.2 24 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 5.90590763206201e-27 3.82004843655648e-25 1.05222116915887 0.852760736196319 24.2 24 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.09573208014187e-14 7.39921096943049e-13 1.05109969708942 0.851851851851852 24.2 24 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.09573208014187e-14 7.39921096943049e-13 1.05109969708942 0.851851851851852 24.2 24 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 1.74602195050988e-05 6.29009933057103e-05 1.05109969708942 0.851851851851852 24.2 24 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 1.74602195050988e-05 6.29009933057103e-05 1.05109969708942 0.851851851851852 24.2 24 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 1.74602195050988e-05 6.29009933057103e-05 1.05109969708942 0.851851851851852 24.2 24 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.21730967139951e-08 7.49883836537446e-08 1.05012735694411 0.851063829787234 24.2 24 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 9.23505963185708e-12 9.80708198218853e-11 1.04973551837808 0.850746268656716 24.2 24 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 9.23505963185708e-12 9.80708198218853e-11 1.04973551837808 0.850746268656716 24.2 24 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.4750329241248e-42 1.18188576122551e-39 1.0495238354746 0.850574712643678 24.2 24 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 7.76624907795698e-17 1.726776943427e-15 1.04881469774793 0.85 24.2 24 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.13695802333311e-26 2.55951794226218e-24 1.04881469774793 0.85 24.2 24 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.68153722490884e-07 7.81969761779502e-07 1.04881469774793 0.85 24.2 24 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000255546094405185 0.000724386638124658 1.04881469774793 0.85 24.2 24 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.21877240411112e-46 2.16789141381266e-44 1.04860413466867 0.849829351535836 24.2 24 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.48132506587724e-16 3.24296241345125e-15 1.04694515283215 0.848484848484849 24.2 24 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 2.35100816011914e-06 9.66903067008538e-06 1.04694515283215 0.848484848484849 24.2 24 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.68787123549356e-82 2.22361358936911e-79 1.04623429925201 0.847908745247148 24.2 24 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.32594250563559e-08 1.32188810053721e-07 1.0461323072166 0.847826086956522 24.2 24 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 2.32594250563559e-08 1.32188810053721e-07 1.0461323072166 0.847826086956522 24.2 24 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.32594250563559e-08 1.32188810053721e-07 1.0461323072166 0.847826086956522 24.2 24 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.3840714917239e-10 1.98393785539363e-09 1.04567766475366 0.847457627118644 24.2 24 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.3840714917239e-10 1.98393785539363e-09 1.04567766475366 0.847457627118644 24.2 24 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 3.35683086285198e-11 3.1324559010717e-10 1.04406892988481 0.846153846153846 24.2 24 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 3.34548839513469e-05 0.000115830413291403 1.04406892988481 0.846153846153846 24.2 24 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 3.34548839513469e-05 0.000115830413291403 1.04406892988481 0.846153846153846 24.2 24 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 3.34548839513469e-05 0.000115830413291403 1.04406892988481 0.846153846153846 24.2 24 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 3.34548839513469e-05 0.000115830413291403 1.04406892988481 0.846153846153846 24.2 24 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00393028140065794 0.00848678366181525 1.04406892988481 0.846153846153846 24.2 24 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00393028140065794 0.00848678366181525 1.04406892988481 0.846153846153846 24.2 24 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00393028140065794 0.00848678366181525 1.04406892988481 0.846153846153846 24.2 24 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00393028140065794 0.00848678366181525 1.04406892988481 0.846153846153846 24.2 24 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00393028140065794 0.00848678366181525 1.04406892988481 0.846153846153846 24.2 24 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00393028140065794 0.00848678366181525 1.04406892988481 0.846153846153846 24.2 24 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.75485255542794e-18 1.60571670321058e-16 1.04320606300061 0.845454545454545 24.2 24 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.42805996578491e-08 2.35997353232656e-07 1.04195969972343 0.844444444444444 24.2 24 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 8.99067994458723e-12 9.69222542511184e-11 1.04000112885929 0.842857142857143 24.2 24 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.56162885806842e-21 2.09393479517141e-19 1.03907338476575 0.842105263157895 24.2 24 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000489446381492594 0.00130936411034294 1.03907338476575 0.842105263157895 24.2 24 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000489446381492594 0.00130936411034294 1.03907338476575 0.842105263157895 24.2 24 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.20715601690241e-10 1.04108061336493e-09 1.03804255799515 0.841269841269841 24.2 24 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 8.39791528800082e-08 4.31416370210295e-07 1.0375974282533 0.840909090909091 24.2 24 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.70066613578266e-11 1.66947969643458e-10 1.03719100544552 0.840579710144927 24.2 24 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.70066613578266e-11 1.66947969643458e-10 1.03719100544552 0.840579710144927 24.2 24 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 6.37070257220645e-05 0.000208402523224133 1.03647570130383 0.84 24.2 24 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 6.37070257220645e-05 0.000208402523224133 1.03647570130383 0.84 24.2 24 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 8.50700209527981e-06 3.21953829297425e-05 1.0348835727304 0.838709677419355 24.2 24 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 1.58633395870062e-07 7.45001063772601e-07 1.03303226043571 0.837209302325581 24.2 24 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.58633395870062e-07 7.45001063772601e-07 1.03303226043571 0.837209302325581 24.2 24 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 4.2916999297795e-10 3.45033276840465e-09 1.03162101417829 0.836065573770492 24.2 24 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 8.51824517827282e-12 9.2530251058643e-11 1.03106682615026 0.835616438356164 24.2 24 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.03789083896913e-19 6.44426369745128e-18 1.02986899454637 0.834645669291339 24.2 24 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.87273115522439e-17 4.75874363193627e-16 1.02824970367444 0.833333333333333 24.2 24 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.17530579713401e-06 8.99843066663284e-06 1.02824970367444 0.833333333333333 24.2 24 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.000120507406657305 0.000374414933784597 1.02824970367444 0.833333333333333 24.2 24 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000120507406657305 0.000374414933784597 1.02824970367444 0.833333333333333 24.2 24 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000929642974504809 0.00236651512114552 1.02824970367444 0.833333333333333 24.2 24 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000929642974504809 0.00236651512114552 1.02824970367444 0.833333333333333 24.2 24 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.000929642974504809 0.00236651512114552 1.02824970367444 0.833333333333333 24.2 24 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000929642974504809 0.00236651512114552 1.02824970367444 0.833333333333333 24.2 24 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000929642974504809 0.00236651512114552 1.02824970367444 0.833333333333333 24.2 24 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000929642974504809 0.00236651512114552 1.02824970367444 0.833333333333333 24.2 24 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.000929642974504809 0.00236651512114552 1.02824970367444 0.833333333333333 24.2 24 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000929642974504809 0.00236651512114552 1.02824970367444 0.833333333333333 24.2 24 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00752113611914801 0.0153993909317232 1.02824970367444 0.833333333333333 24.2 24 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00752113611914801 0.0153993909317232 1.02824970367444 0.833333333333333 24.2 24 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00752113611914801 0.0153993909317232 1.02824970367444 0.833333333333333 24.2 24 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00752113611914801 0.0153993909317232 1.02824970367444 0.833333333333333 24.2 24 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00752113611914801 0.0153993909317232 1.02824970367444 0.833333333333333 24.2 24 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00752113611914801 0.0153993909317232 1.02824970367444 0.833333333333333 24.2 24 2 HYDROLYSIS OF LPC%REACTOME%REACT_199022.2 HYDROLYSIS OF LPC 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 48%5605140 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_196559.2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.0676023797418903 0.106179013656413 1.02824970367444 0.833333333333333 24.2 24 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.25969898848293e-12 2.81824495784546e-11 1.02824970367444 0.833333333333333 24.2 24 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 2.98858072494948e-11 2.85419488027054e-10 1.02535322563592 0.830985915492958 24.2 24 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.11886054691723e-10 1.79472533229953e-09 1.02508585843236 0.830769230769231 24.2 24 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.07661191330153e-08 6.71938049398279e-08 1.0243695161134 0.830188679245283 24.2 24 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 5.57505715218179e-11 4.92751945810851e-10 1.02237399108201 0.828571428571429 24.2 24 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 4.07634717266602e-06 1.60238730019441e-05 1.02237399108201 0.828571428571429 24.2 24 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 4.07634717266602e-06 1.60238730019441e-05 1.02237399108201 0.828571428571429 24.2 24 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.26849749899797e-16 4.89101809253654e-15 1.02077152401135 0.827272727272727 24.2 24 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 2.00755217058534e-08 1.17253114233714e-07 1.02034009056925 0.826923076923077 24.2 24 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 2.00755217058534e-08 1.17253114233714e-07 1.02034009056925 0.826923076923077 24.2 24 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.46741260581644e-11 1.49152009862628e-10 1.02002370604504 0.826666666666667 24.2 24 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.03706051839809e-10 9.05360194896003e-10 1.01930840190335 0.826086956521739 24.2 24 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.44131179014942e-07 6.8366222579421e-07 1.01930840190335 0.826086956521739 24.2 24 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000226303593208406 0.00066672880566369 1.01930840190335 0.826086956521739 24.2 24 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.8638046972826e-12 4.29546412830714e-11 1.01796720663769 0.825 24.2 24 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.04179530236041e-06 4.45187602179837e-06 1.01796720663769 0.825 24.2 24 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.04179530236041e-06 4.45187602179837e-06 1.01796720663769 0.825 24.2 24 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.95878464720208e-17 7.2592250913251e-16 1.01615264833709 0.823529411764706 24.2 24 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.72936985031227e-08 2.01783015094843e-07 1.01615264833709 0.823529411764706 24.2 24 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.72936985031227e-08 2.01783015094843e-07 1.01615264833709 0.823529411764706 24.2 24 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 7.59793378244625e-06 2.89087159690402e-05 1.01615264833709 0.823529411764706 24.2 24 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 7.59793378244625e-06 2.89087159690402e-05 1.01615264833709 0.823529411764706 24.2 24 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 7.59793378244625e-06 2.89087159690402e-05 1.01615264833709 0.823529411764706 24.2 24 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00174942643980669 0.00413527213263275 1.01615264833709 0.823529411764706 24.2 24 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.44452351031738e-15 2.66955448724886e-14 1.01479596923384 0.822429906542056 24.2 24 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.67584961532492e-07 1.23627727357382e-06 1.01453970762544 0.822222222222222 24.2 24 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.07613894092945e-18 6.029276965189e-17 1.01390203339061 0.821705426356589 24.2 24 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 5.60988215931803e-05 0.000186515474596018 1.01356042219337 0.821428571428571 24.2 24 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 5.60988215931803e-05 0.000186515474596018 1.01356042219337 0.821428571428571 24.2 24 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 5.60988215931803e-05 0.000186515474596018 1.01356042219337 0.821428571428571 24.2 24 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 5.60988215931803e-05 0.000186515474596018 1.01356042219337 0.821428571428571 24.2 24 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 5.60988215931803e-05 0.000186515474596018 1.01356042219337 0.821428571428571 24.2 24 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 5.60988215931803e-05 0.000186515474596018 1.01356042219337 0.821428571428571 24.2 24 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.308842138963e-30 1.2416549091629e-28 1.01257235393232 0.820627802690583 24.2 24 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.86345155250446e-14 3.04792133242971e-13 1.01179770841565 0.82 24.2 24 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.78556942794675e-08 1.05869387332009e-07 1.00955425451672 0.818181818181818 24.2 24 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 1.40815679771445e-05 5.17779618384409e-05 1.00955425451672 0.818181818181818 24.2 24 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 1.40815679771445e-05 5.17779618384409e-05 1.00955425451672 0.818181818181818 24.2 24 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.94577489325297e-07 2.22013806722365e-06 1.00955425451672 0.818181818181818 24.2 24 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000421638548621142 0.001140668545034 1.00955425451672 0.818181818181818 24.2 24 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000421638548621142 0.001140668545034 1.00955425451672 0.818181818181818 24.2 24 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0142074083959174 0.0268272303716717 1.00955425451672 0.818181818181818 24.2 24 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 6.38227049981141e-12 6.98613147787048e-11 1.00818629482225 0.817073170731707 24.2 24 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 4.63294524281173e-09 3.01035665777219e-08 1.00768470960095 0.816666666666667 24.2 24 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.27168830181509e-07 6.07643451525861e-07 1.00726501584435 0.816326530612245 24.2 24 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.27168830181509e-07 6.07643451525861e-07 1.00726501584435 0.816326530612245 24.2 24 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.28249039563327e-08 1.79653224345621e-07 1.00539971025945 0.814814814814815 24.2 24 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000103831407514839 0.000326885161269061 1.00539971025945 0.814814814814815 24.2 24 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000103831407514839 0.000326885161269061 1.00539971025945 0.814814814814815 24.2 24 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000103831407514839 0.000326885161269061 1.00539971025945 0.814814814814815 24.2 24 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.17086478702127e-11 1.20734825502266e-10 1.00539971025945 0.814814814814815 24.2 24 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00325810311940347 0.00722162108864663 1.00254346108258 0.8125 24.2 24 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00325810311940347 0.00722162108864663 1.00254346108258 0.8125 24.2 24 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00325810311940347 0.00722162108864663 1.00254346108258 0.8125 24.2 24 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00325810311940347 0.00722162108864663 1.00254346108258 0.8125 24.2 24 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00325810311940347 0.00722162108864663 1.00254346108258 0.8125 24.2 24 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00325810311940347 0.00722162108864663 1.00254346108258 0.8125 24.2 24 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00325810311940347 0.00722162108864663 1.00254346108258 0.8125 24.2 24 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 5.60663617189118e-12 6.18468470744275e-11 1.00163618193227 0.811764705882353 24.2 24 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.55367640156693e-08 9.36814203148197e-08 0.999884194607556 0.810344827586207 24.2 24 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.55367640156693e-08 9.36814203148197e-08 0.999884194607556 0.810344827586207 24.2 24 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.90856537357426e-11 3.61161592636115e-10 0.999614901799959 0.810126582278481 24.2 24 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 4.02783379892859e-09 2.6412937769011e-08 0.99887114071231 0.80952380952381 24.2 24 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.02197800626655e-11 1.06151438169146e-10 0.99887114071231 0.80952380952381 24.2 24 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.02197800626655e-11 1.06151438169146e-10 0.99887114071231 0.80952380952381 24.2 24 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.66575285558008e-06 7.01291808724986e-06 0.99887114071231 0.80952380952381 24.2 24 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.41362101023324e-28 1.71729134878095e-26 0.99833698502209 0.809090909090909 24.2 24 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.04674847820411e-09 7.96536408815215e-09 0.998007065331071 0.808823529411765 24.2 24 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 9.02058192928922e-24 4.58438860192091e-22 0.997907909139781 0.808743169398907 24.2 24 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.09610041051656e-07 5.39706188292408e-07 0.996611251253685 0.807692307692308 24.2 24 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.000190766021159078 0.000564366004385379 0.996611251253685 0.807692307692308 24.2 24 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000190766021159078 0.000564366004385379 0.996611251253685 0.807692307692308 24.2 24 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000190766021159078 0.000564366004385379 0.996611251253685 0.807692307692308 24.2 24 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000190766021159078 0.000564366004385379 0.996611251253685 0.807692307692308 24.2 24 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.90189367407249e-09 1.40958057198185e-08 0.994486280568709 0.805970149253731 24.2 24 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.94851270341926e-10 3.93392937260648e-09 0.993974713551956 0.805555555555556 24.2 24 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 1.19520900141558e-05 4.44068514102968e-05 0.993974713551956 0.805555555555556 24.2 24 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.19520900141558e-05 4.44068514102968e-05 0.993974713551956 0.805555555555556 24.2 24 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.29823273658816e-14 3.63376131573883e-13 0.993974713551956 0.805555555555556 24.2 24 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 4.17353150905679e-16 8.60715266288088e-15 0.993138738183115 0.804878048780488 24.2 24 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.3679954523118e-11 3.1324559010717e-10 0.993138738183115 0.804878048780488 24.2 24 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.03395219895498e-06 1.21272864581824e-05 0.993138738183115 0.804878048780488 24.2 24 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.03395219895498e-06 1.21272864581824e-05 0.993138738183115 0.804878048780488 24.2 24 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 7.75117178549083e-07 3.40429550949181e-06 0.992484496590109 0.804347826086957 24.2 24 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 5.13175285419333e-08 2.67855579764027e-07 0.991526499971779 0.803571428571429 24.2 24 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.32756168573863e-08 8.07316358464135e-08 0.99116528813208 0.80327868852459 24.2 24 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.32756168573863e-08 8.07316358464135e-08 0.99116528813208 0.80327868852459 24.2 24 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 8.95474892929081e-10 6.88789606831396e-09 0.990595489173683 0.802816901408451 24.2 24 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.33298994601227e-10 1.96440514389081e-09 0.990366819854852 0.802631578947368 24.2 24 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.59115372240388e-11 1.59451531477516e-10 0.989989249584225 0.802325581395349 24.2 24 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.59115372240388e-11 1.59451531477516e-10 0.989989249584225 0.802325581395349 24.2 24 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 9.112774193246e-26 5.40311569874544e-24 0.98711971552746 0.8 24.2 24 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.39667694967392e-08 1.32188810053721e-07 0.98711971552746 0.8 24.2 24 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.39667694967392e-08 1.32188810053721e-07 0.98711971552746 0.8 24.2 24 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.39667694967392e-08 1.32188810053721e-07 0.98711971552746 0.8 24.2 24 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.39667694967392e-08 1.32188810053721e-07 0.98711971552746 0.8 24.2 24 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.39667694967392e-08 1.32188810053721e-07 0.98711971552746 0.8 24.2 24 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.39667694967392e-08 1.32188810053721e-07 0.98711971552746 0.8 24.2 24 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.39667694967392e-08 1.32188810053721e-07 0.98711971552746 0.8 24.2 24 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 9.2701742663793e-08 4.5963268226682e-07 0.98711971552746 0.8 24.2 24 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 9.2701742663793e-08 4.5963268226682e-07 0.98711971552746 0.8 24.2 24 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 9.2701742663793e-08 4.5963268226682e-07 0.98711971552746 0.8 24.2 24 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 9.2701742663793e-08 4.5963268226682e-07 0.98711971552746 0.8 24.2 24 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 9.2701742663793e-08 4.5963268226682e-07 0.98711971552746 0.8 24.2 24 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 9.2701742663793e-08 4.5963268226682e-07 0.98711971552746 0.8 24.2 24 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 3.59813462118604e-07 1.62544303680881e-06 0.98711971552746 0.8 24.2 24 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 8.63116972577193e-05 0.00027354464409295 0.98711971552746 0.8 24.2 24 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00034770893039827 0.000949692529667445 0.98711971552746 0.8 24.2 24 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00034770893039827 0.000949692529667445 0.98711971552746 0.8 24.2 24 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00034770893039827 0.000949692529667445 0.98711971552746 0.8 24.2 24 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00034770893039827 0.000949692529667445 0.98711971552746 0.8 24.2 24 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00034770893039827 0.000949692529667445 0.98711971552746 0.8 24.2 24 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00034770893039827 0.000949692529667445 0.98711971552746 0.8 24.2 24 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00599728986594763 0.0125317819078465 0.98711971552746 0.8 24.2 24 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00599728986594763 0.0125317819078465 0.98711971552746 0.8 24.2 24 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00599728986594763 0.0125317819078465 0.98711971552746 0.8 24.2 24 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00599728986594763 0.0125317819078465 0.98711971552746 0.8 24.2 24 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00599728986594763 0.0125317819078465 0.98711971552746 0.8 24.2 24 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00599728986594763 0.0125317819078465 0.98711971552746 0.8 24.2 24 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.16842802215673e-05 7.71418268882257e-05 0.987119715527459 0.8 24.2 24 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 2.16842802215673e-05 7.71418268882257e-05 0.987119715527459 0.8 24.2 24 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 2.86723556257629e-11 2.75680824699059e-10 0.987119715527459 0.8 24.2 24 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 2.86723556257629e-11 2.75680824699059e-10 0.987119715527459 0.8 24.2 24 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.40254760049654e-06 5.92233007568715e-06 0.987119715527459 0.8 24.2 24 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00142504752984223 0.00351445863945493 0.987119715527459 0.8 24.2 24 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00142504752984223 0.00351445863945493 0.987119715527459 0.8 24.2 24 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00142504752984223 0.00351445863945493 0.987119715527459 0.8 24.2 24 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00142504752984223 0.00351445863945493 0.987119715527459 0.8 24.2 24 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.02643062600453 0.0462048904231525 0.987119715527459 0.8 24.2 24 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.02643062600453 0.0462048904231525 0.987119715527459 0.8 24.2 24 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.02643062600453 0.0462048904231525 0.987119715527459 0.8 24.2 24 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.02643062600453 0.0462048904231525 0.987119715527459 0.8 24.2 24 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.02643062600453 0.0462048904231525 0.987119715527459 0.8 24.2 24 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.02643062600453 0.0462048904231525 0.987119715527459 0.8 24.2 24 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.02643062600453 0.0462048904231525 0.987119715527459 0.8 24.2 24 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.02643062600453 0.0462048904231525 0.987119715527459 0.8 24.2 24 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.10984185729923e-17 5.26720168936281e-16 0.985344320355648 0.798561151079137 24.2 24 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 7.55990517170718e-10 5.91084893370292e-09 0.98378485162365 0.797297297297297 24.2 24 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 7.55990517170718e-10 5.91084893370292e-09 0.98378485162365 0.797297297297297 24.2 24 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.66750052673345e-07 7.77984671980884e-07 0.982549716844462 0.796296296296296 24.2 24 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 5.83888298281845e-19 1.80624575751101e-17 0.980792025043309 0.794871794871795 24.2 24 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 3.90898712995524e-05 0.000134684956075698 0.979861482325052 0.794117647058823 24.2 24 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.00104342702324e-08 1.17253114233714e-07 0.979285432070892 0.793650793650794 24.2 24 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.31507234830185e-11 3.88629617191996e-10 0.978610062807395 0.793103448275862 24.2 24 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.31507234830185e-11 3.88629617191996e-10 0.978610062807395 0.793103448275862 24.2 24 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 9.58226555151472e-14 1.35005582968371e-12 0.978226745117302 0.792792792792793 24.2 24 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 2.98625650857943e-07 1.3620009652912e-06 0.977807265380974 0.792452830188679 24.2 24 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.41784465876021e-09 1.60775371468027e-08 0.976837218490715 0.791666666666667 24.2 24 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 9.2814291660995e-09 5.86998831260426e-08 0.976069867965585 0.791044776119403 24.2 24 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.57017338308156e-08 1.94649682916669e-07 0.975178751226724 0.790322580645161 24.2 24 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 5.87675515666798e-18 1.60819665152664e-16 0.974131298217888 0.789473684210526 24.2 24 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 9.39863351270313e-12 9.90685591746412e-11 0.974131298217888 0.789473684210526 24.2 24 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.12314656780293e-09 8.50126364884881e-09 0.974131298217888 0.789473684210526 24.2 24 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00258038019830061 0.00581914583547032 0.974131298217888 0.789473684210526 24.2 24 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00258038019830061 0.00581914583547032 0.974131298217888 0.789473684210526 24.2 24 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.0310302274188e-13 4.10776763201615e-12 0.973535499258733 0.788990825688073 24.2 24 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 6.99889827462554e-05 0.000223305655712828 0.972163356201286 0.787878787878788 24.2 24 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.74049643020152e-14 2.87991444206601e-13 0.970937425108977 0.786885245901639 24.2 24 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 5.20448279654241e-21 2.31436844358745e-19 0.970937425108977 0.786885245901639 24.2 24 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.65908600568776e-30 1.47554961630855e-28 0.970788690822042 0.786764705882353 24.2 24 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.35512987411933e-58 3.21391635145301e-56 0.970482866389356 0.786516853932584 24.2 24 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.27915053418142e-18 6.48646242028033e-17 0.970046890258903 0.786163522012579 24.2 24 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 9.83252675200697e-24 4.82471916141583e-22 0.969492577750183 0.785714285714286 24.2 24 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.5030548550422e-13 3.42485294108178e-12 0.969492577750183 0.785714285714286 24.2 24 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000278850889227586 0.000788876372506669 0.969492577750183 0.785714285714286 24.2 24 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0108939268814898 0.0210054985804336 0.969492577750183 0.785714285714286 24.2 24 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0108939268814898 0.0210054985804336 0.969492577750183 0.785714285714286 24.2 24 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0108939268814898 0.0210054985804336 0.969492577750183 0.785714285714286 24.2 24 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0108939268814898 0.0210054985804336 0.969492577750183 0.785714285714286 24.2 24 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0108939268814898 0.0210054985804336 0.969492577750183 0.785714285714286 24.2 24 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.64307116376331e-16 5.61356756124654e-15 0.969492577750183 0.785714285714286 24.2 24 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 8.05068312466295e-06 3.05496588970543e-05 0.969492577750183 0.785714285714286 24.2 24 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.07634777993574e-14 4.56004467796725e-13 0.968764183627156 0.785123966942149 24.2 24 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.07634777993574e-14 4.56004467796725e-13 0.968764183627156 0.785123966942149 24.2 24 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 7.44947709758207e-29 5.88922550547738e-27 0.968136644075008 0.784615384615385 24.2 24 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 7.09806086335198e-18 1.90576237897167e-16 0.966685708677369 0.78343949044586 24.2 24 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.12267334329262e-07 5.50884195691517e-07 0.966554721453971 0.783333333333333 24.2 24 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 3.6612971195073e-06 1.45531446956952e-05 0.965660591276863 0.782608695652174 24.2 24 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00112484438810699 0.00279346171775959 0.965660591276863 0.782608695652174 24.2 24 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00112484438810699 0.00279346171775959 0.965660591276863 0.782608695652174 24.2 24 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.15758459981331e-08 2.67855579764027e-07 0.963984097194785 0.78125 24.2 24 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 5.15758459981331e-08 2.67855579764027e-07 0.963984097194785 0.78125 24.2 24 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000124409408433866 0.000385696270591268 0.963984097194785 0.78125 24.2 24 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.20683736422677e-09 3.99652921687543e-08 0.963455886730568 0.780821917808219 24.2 24 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.09445346077244e-20 4.44973507051193e-19 0.963365497774125 0.780748663101604 24.2 24 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.55555913264538e-19 5.03081964944175e-18 0.962023451573372 0.779661016949153 24.2 24 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.97814581791813e-07 9.16906025699512e-07 0.962023451573372 0.779661016949153 24.2 24 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.05984551286911e-14 3.33086382365085e-13 0.961858777925379 0.779527559055118 24.2 24 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.47053276480474e-10 2.80600461608929e-09 0.961293909016567 0.779069767441861 24.2 24 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.22845555318732e-11 3.85711041806766e-10 0.961142880908316 0.778947368421053 24.2 24 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.22845555318732e-11 3.85711041806766e-10 0.961142880908316 0.778947368421053 24.2 24 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.1774630708853e-15 2.20464467088128e-14 0.960679008861545 0.778571428571429 24.2 24 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.7895587829138e-17 4.63007663288424e-16 0.960567444698398 0.778481012658228 24.2 24 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.08953714971907e-08 6.77035530152943e-08 0.959699723429475 0.777777777777778 24.2 24 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 5.57469459475075e-05 0.000186515474596018 0.959699723429475 0.777777777777778 24.2 24 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00461866856836327 0.00978030561425733 0.959699723429475 0.777777777777778 24.2 24 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00461866856836327 0.00978030561425733 0.959699723429475 0.777777777777778 24.2 24 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0482786108245305 0.0786046489740353 0.959699723429475 0.777777777777778 24.2 24 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0482786108245305 0.0786046489740353 0.959699723429475 0.777777777777778 24.2 24 2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.0482786108245305 0.0786046489740353 0.959699723429475 0.777777777777778 24.2 24 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0482786108245305 0.0786046489740353 0.959699723429475 0.777777777777778 24.2 24 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0482786108245305 0.0786046489740353 0.959699723429475 0.777777777777778 24.2 24 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0482786108245305 0.0786046489740353 0.959699723429475 0.777777777777778 24.2 24 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0482786108245305 0.0786046489740353 0.959699723429475 0.777777777777778 24.2 24 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0482786108245305 0.0786046489740353 0.959699723429475 0.777777777777778 24.2 24 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000495037168913915 0.00130936411034294 0.959699723429475 0.777777777777778 24.2 24 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000495037168913915 0.00130936411034294 0.959699723429475 0.777777777777778 24.2 24 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000495037168913915 0.00130936411034294 0.959699723429475 0.777777777777778 24.2 24 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 5.01017201092938e-09 3.24067035070568e-08 0.957895776580923 0.776315789473684 24.2 24 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 2.50702422396858e-05 8.89649743318525e-05 0.956272224417226 0.775 24.2 24 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.58550574498118e-07 7.45001063772601e-07 0.955277144058832 0.774193548387097 24.2 24 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.88091370332396e-10 3.90198887630899e-09 0.953467907043569 0.772727272727273 24.2 24 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.13088189979608e-05 4.23485511423636e-05 0.953467907043569 0.772727272727273 24.2 24 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.13088189979608e-05 4.23485511423636e-05 0.953467907043569 0.772727272727273 24.2 24 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00199327045383898 0.00466517081548169 0.953467907043569 0.772727272727273 24.2 24 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00199327045383898 0.00466517081548169 0.953467907043569 0.772727272727273 24.2 24 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00199327045383898 0.00466517081548169 0.953467907043569 0.772727272727273 24.2 24 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00199327045383898 0.00466517081548169 0.953467907043569 0.772727272727273 24.2 24 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.93017485981144e-87 1.37331941275584e-84 0.950549386699943 0.770361990950226 24.2 24 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 8.47739139079137e-10 6.59198248584487e-09 0.950244553740514 0.770114942528736 24.2 24 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 4.03529891744394e-15 7.00271995063748e-14 0.949153572622557 0.769230769230769 24.2 24 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0194906518474482 0.0347558866903745 0.949153572622557 0.769230769230769 24.2 24 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0194906518474482 0.0347558866903745 0.949153572622557 0.769230769230769 24.2 24 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0194906518474482 0.0347558866903745 0.949153572622557 0.769230769230769 24.2 24 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0194906518474482 0.0347558866903745 0.949153572622557 0.769230769230769 24.2 24 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0194906518474482 0.0347558866903745 0.949153572622557 0.769230769230769 24.2 24 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0194906518474482 0.0347558866903745 0.949153572622557 0.769230769230769 24.2 24 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0194906518474482 0.0347558866903745 0.949153572622557 0.769230769230769 24.2 24 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 4.38163854506665e-05 0.000150242690352526 0.949153572622557 0.769230769230769 24.2 24 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 4.38163854506665e-05 0.000150242690352526 0.949153572622557 0.769230769230769 24.2 24 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 4.93055964876445e-17 1.16936439669863e-15 0.9479960682657 0.768292682926829 24.2 24 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 3.98505003985989e-16 8.33930324517739e-15 0.947316501191675 0.767741935483871 24.2 24 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000383908976340323 0.00104256197200817 0.945989727380482 0.766666666666667 24.2 24 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000383908976340323 0.00104256197200817 0.945989727380482 0.766666666666667 24.2 24 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 6.73940640516235e-10 5.32787517474779e-09 0.945989727380482 0.766666666666667 24.2 24 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.04147300379154e-18 3.08753350915702e-17 0.945542662291928 0.766304347826087 24.2 24 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.5727899436722e-13 6.02507415726438e-12 0.945326340474886 0.766129032258065 24.2 24 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.5727899436722e-13 6.02507415726438e-12 0.945326340474886 0.766129032258065 24.2 24 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.5727899436722e-13 6.02507415726438e-12 0.945326340474886 0.766129032258065 24.2 24 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000170411094948041 0.000511592801922071 0.943570316313013 0.764705882352941 24.2 24 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00816130232809298 0.0162654526790985 0.943570316313013 0.764705882352941 24.2 24 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00816130232809298 0.0162654526790985 0.943570316313013 0.764705882352941 24.2 24 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00816130232809298 0.0162654526790985 0.943570316313013 0.764705882352941 24.2 24 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00816130232809298 0.0162654526790985 0.943570316313013 0.764705882352941 24.2 24 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00816130232809298 0.0162654526790985 0.943570316313013 0.764705882352941 24.2 24 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 4.54489386509865e-08 2.41116250434661e-07 0.942562228368234 0.763888888888889 24.2 24 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 1.82020696761575e-06 7.61810151446237e-06 0.942250637548939 0.763636363636364 24.2 24 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00349295124777311 0.00771812053661667 0.940114014788057 0.761904761904762 24.2 24 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00029447323870765 0.000829773106298983 0.934772457885852 0.757575757575758 24.2 24 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00013105309904558 0.000404530498789285 0.933761893066516 0.756756756756757 24.2 24 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 1.18557987524749e-05 4.42803192251227e-05 0.931720139656021 0.755102040816326 24.2 24 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 5.35601040319888e-06 2.07673100919673e-05 0.931245014648547 0.754716981132076 24.2 24 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 8.49188115652963e-07 3.70673217354039e-06 0.925424733306993 0.75 24.2 24 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 8.49188115652963e-07 3.70673217354039e-06 0.925424733306993 0.75 24.2 24 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00261439024612021 0.0058772153558121 0.925424733306993 0.75 24.2 24 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.00261439024612021 0.0058772153558121 0.925424733306993 0.75 24.2 24 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0142148501055801 0.0268272303716717 0.925424733306993 0.75 24.2 24 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0142148501055801 0.0268272303716717 0.925424733306993 0.75 24.2 24 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0342662252262257 0.0589611106371453 0.925424733306993 0.75 24.2 24 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0342662252262257 0.0589611106371453 0.925424733306993 0.75 24.2 24 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0342662252262257 0.0589611106371453 0.925424733306993 0.75 24.2 24 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0342662252262257 0.0589611106371453 0.925424733306993 0.75 24.2 24 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0342662252262257 0.0589611106371453 0.925424733306993 0.75 24.2 24 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0862439221712749 0.132675785134837 0.925424733306993 0.75 24.2 24 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 6.46234615300769e-15 1.1079419970759e-13 0.925424733306993 0.75 24.2 24 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00604637820367578 0.0125973589807184 0.925424733306993 0.75 24.2 24 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00604637820367578 0.0125973589807184 0.925424733306993 0.75 24.2 24 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.36412593356672e-14 3.69686945435763e-13 0.923434572590204 0.748387096774194 24.2 24 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.1587157527498e-06 1.25906232945741e-05 0.920196344983225 0.745762711864407 24.2 24 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.04049864662779e-28 3.41553789245302e-26 0.919747280955417 0.745398773006135 24.2 24 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00016954305881032 0.000510062944370159 0.917515120201805 0.743589743589744 24.2 24 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00016954305881032 0.000510062944370159 0.917515120201805 0.743589743589744 24.2 24 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 4.99615553863148e-07 2.23570104763289e-06 0.916611164418355 0.742857142857143 24.2 24 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.000856738889427498 0.00221259426434724 0.915473929723047 0.741935483870968 24.2 24 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.66952312781573e-08 9.94029879030033e-08 0.915026702595679 0.741573033707865 24.2 24 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.90780307113696e-12 2.44576916236747e-11 0.914328513483168 0.741007194244604 24.2 24 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00194460851057174 0.00458901809377045 0.9139997365995 0.740740740740741 24.2 24 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 5.74259846471048e-05 0.000189641358276832 0.91201278065037 0.739130434782609 24.2 24 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000127707684726327 0.000395060946446877 0.91073545182593 0.738095238095238 24.2 24 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000285050593160815 0.000804815464420317 0.909189211670028 0.736842105263158 24.2 24 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0103258760045387 0.0200460048491931 0.909189211670028 0.736842105263158 24.2 24 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00144076053754955 0.00354706270749654 0.904859739233505 0.733333333333333 24.2 24 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0243596786742308 0.0430072242598393 0.904859739233505 0.733333333333333 24.2 24 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0243596786742308 0.0430072242598393 0.904859739233505 0.733333333333333 24.2 24 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.13487214281133e-11 2.95425368160299e-10 0.904231800483169 0.732824427480916 24.2 24 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.13487214281133e-11 2.95425368160299e-10 0.904231800483169 0.732824427480916 24.2 24 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000213085723763033 0.000629089180321153 0.902853398348286 0.731707317073171 24.2 24 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0032706805041344 0.00723822450603926 0.901695893991429 0.730769230769231 24.2 24 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.87609040538394e-75 1.37891916171534e-72 0.900413254028426 0.72972972972973 24.2 24 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.26433995555115e-07 6.07643451525861e-07 0.900020917098566 0.729411764705882 24.2 24 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.26433995555115e-07 6.07643451525861e-07 0.900020917098566 0.729411764705882 24.2 24 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.26433995555115e-07 6.07643451525861e-07 0.900020917098566 0.729411764705882 24.2 24 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.26433995555115e-07 6.07643451525861e-07 0.900020917098566 0.729411764705882 24.2 24 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.26433995555115e-07 6.07643451525861e-07 0.900020917098566 0.729411764705882 24.2 24 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 1.73840107048049e-06 7.29718207461278e-06 0.898984026641079 0.728571428571429 24.2 24 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.75345713080403e-07 1.26392564423682e-06 0.898766407656174 0.728395061728395 24.2 24 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 4.39375432384356e-08 2.35049338452232e-07 0.898600827993747 0.728260869565217 24.2 24 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 3.80129133923346e-06 1.50675141385215e-05 0.897381559570418 0.727272727272727 24.2 24 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00106478170617693 0.00265356281591904 0.897381559570418 0.727272727272727 24.2 24 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00106478170617693 0.00265356281591904 0.897381559570418 0.727272727272727 24.2 24 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00106478170617693 0.00265356281591904 0.897381559570418 0.727272727272727 24.2 24 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 9.5497883375202e-08 4.7185238903789e-07 0.897381559570418 0.727272727272727 24.2 24 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.05902587296083 0.0948011481075181 0.897381559570418 0.727272727272727 24.2 24 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.05902587296083 0.0948011481075181 0.897381559570418 0.727272727272727 24.2 24 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.05902587296083 0.0948011481075181 0.897381559570418 0.727272727272727 24.2 24 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.05902587296083 0.0948011481075181 0.897381559570418 0.727272727272727 24.2 24 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.05902587296083 0.0948011481075181 0.897381559570418 0.727272727272727 24.2 24 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 3.03811072783874e-33 3.32556274285733e-31 0.896375526431886 0.726457399103139 24.2 24 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000352739337726194 0.000961586355525622 0.89457724219676 0.725 24.2 24 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00239797837316197 0.00543363570861383 0.893513535606752 0.724137931034483 24.2 24 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 8.38857284287805e-36 1.08517628685595e-33 0.892821693922194 0.723577235772358 24.2 24 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.50048837429578e-20 5.93109710173027e-19 0.890902270331642 0.72202166064982 24.2 24 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 3.06801164328986e-08 1.68562956308937e-07 0.888407743974714 0.72 24.2 24 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.22533208099669e-14 3.55803095646998e-13 0.886865369419202 0.71875 24.2 24 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0409824642623443 0.0675759520803197 0.881356888863803 0.714285714285714 24.2 24 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0409824642623443 0.0675759520803197 0.881356888863803 0.714285714285714 24.2 24 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0409824642623443 0.0675759520803197 0.881356888863803 0.714285714285714 24.2 24 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0409824642623443 0.0675759520803197 0.881356888863803 0.714285714285714 24.2 24 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0409824642623443 0.0675759520803197 0.881356888863803 0.714285714285714 24.2 24 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.149857888624548 0.212822131250231 0.881356888863803 0.714285714285714 24.2 24 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 7.01305238339095e-14 9.97957354156533e-13 0.880438808771237 0.713541666666667 24.2 24 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.03834610679131e-09 2.01096116742513e-08 0.875670715387262 0.709677419354839 24.2 24 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.27054603794257e-50 2.58283858856039e-48 0.875263000003541 0.709346991037132 24.2 24 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.77360263750186e-10 2.28140841223419e-09 0.875106130786755 0.709219858156028 24.2 24 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000231178093189212 0.000668435761360336 0.874012248123272 0.708333333333333 24.2 24 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00892097559683811 0.0174136464668047 0.874012248123272 0.708333333333333 24.2 24 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00892097559683811 0.0174136464668047 0.874012248123272 0.708333333333333 24.2 24 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00892097559683811 0.0174136464668047 0.874012248123272 0.708333333333333 24.2 24 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 5.77053465452342e-05 0.000189641358276832 0.872239403806591 0.706896551724138 24.2 24 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 5.77053465452342e-05 0.000189641358276832 0.872239403806591 0.706896551724138 24.2 24 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 5.77053465452342e-05 0.000189641358276832 0.872239403806591 0.706896551724138 24.2 24 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 7.10155620533425e-17 1.60404991749058e-15 0.871564034543094 0.706349206349206 24.2 24 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 7.10155620533425e-17 1.60404991749058e-15 0.871564034543094 0.706349206349206 24.2 24 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 7.10155620533425e-17 1.60404991749058e-15 0.871564034543094 0.706349206349206 24.2 24 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.9950092486527e-24 1.57848080030844e-22 0.870987984288935 0.705882352941177 24.2 24 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0287433647715491 0.0501247647915618 0.870987984288935 0.705882352941177 24.2 24 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0287433647715491 0.0501247647915618 0.870987984288935 0.705882352941177 24.2 24 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0064201014888457 0.0133174991525181 0.868299749769525 0.703703703703704 24.2 24 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0064201014888457 0.0133174991525181 0.868299749769525 0.703703703703704 24.2 24 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0064201014888457 0.0133174991525181 0.868299749769525 0.703703703703704 24.2 24 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00151915828271322 0.00373361353419846 0.867064614990336 0.702702702702703 24.2 24 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.22568300696933e-08 7.51787465050586e-08 0.866789006403244 0.702479338842975 24.2 24 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0203113708732189 0.0360387540555991 0.863729751086527 0.7 24.2 24 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0203113708732189 0.0360387540555991 0.863729751086527 0.7 24.2 24 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0203113708732189 0.0360387540555991 0.863729751086527 0.7 24.2 24 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0992572420711984 0.146822302980577 0.863729751086527 0.7 24.2 24 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0992572420711984 0.146822302980577 0.863729751086527 0.7 24.2 24 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0992572420711984 0.146822302980577 0.863729751086527 0.7 24.2 24 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0992572420711984 0.146822302980577 0.863729751086527 0.7 24.2 24 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0992572420711984 0.146822302980577 0.863729751086527 0.7 24.2 24 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0992572420711984 0.146822302980577 0.863729751086527 0.7 24.2 24 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.14202986004587e-92 5.89410849084527e-89 0.861101042999664 0.697869593285991 24.2 24 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0144367607360193 0.0271739557240151 0.858364970023878 0.695652173913043 24.2 24 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0144367607360193 0.0271739557240151 0.858364970023878 0.695652173913043 24.2 24 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 6.25470885991217e-14 8.99035425015658e-13 0.857643250598409 0.695067264573991 24.2 24 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.000430876398988987 0.00116344803749778 0.856175263467694 0.693877551020408 24.2 24 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0103091214679889 0.0200408194657762 0.854238215360302 0.692307692307692 24.2 24 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0103091214679889 0.0200408194657762 0.854238215360302 0.692307692307692 24.2 24 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0675112653284748 0.106179013656413 0.854238215360302 0.692307692307692 24.2 24 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0675112653284748 0.106179013656413 0.854238215360302 0.692307692307692 24.2 24 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.45185750514966e-32 1.47570944987712e-30 0.85357330917983 0.691768826619965 24.2 24 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.000677623008867492 0.00177253224562214 0.848306005531411 0.6875 24.2 24 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0466783015252624 0.076789853260634 0.848306005531411 0.6875 24.2 24 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.28621999582107e-13 1.79440299416999e-12 0.847313060538592 0.686695278969957 24.2 24 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.95872390824837e-34 7.06605343453119e-32 0.842429150693147 0.682737169517885 24.2 24 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0230110432259358 0.0407272568538639 0.841295212097266 0.681818181818182 24.2 24 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0116407984570414 0.0224152316703247 0.837289044420613 0.678571428571429 24.2 24 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00833403371185141 0.0165633100167103 0.835867501051478 0.67741935483871 24.2 24 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00833403371185141 0.0165633100167103 0.835867501051478 0.67741935483871 24.2 24 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.87961334379944e-06 7.79792941173936e-06 0.8343511881244 0.676190476190476 24.2 24 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00163399237407462 0.00393429974333027 0.831541064710632 0.673913043478261 24.2 24 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0742280354385711 0.116073070801194 0.82259976293955 0.666666666666667 24.2 24 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.108545168430039 0.159730894184018 0.82259976293955 0.666666666666667 24.2 24 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.108545168430039 0.159730894184018 0.82259976293955 0.666666666666667 24.2 24 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.108545168430039 0.159730894184018 0.82259976293955 0.666666666666667 24.2 24 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.108545168430039 0.159730894184018 0.82259976293955 0.666666666666667 24.2 24 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.108545168430039 0.159730894184018 0.82259976293955 0.666666666666667 24.2 24 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0180871614262752 0.0325385976101006 0.82259976293955 0.666666666666667 24.2 24 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.162174544864764 0.228489482517385 0.82259976293955 0.666666666666667 24.2 24 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.162174544864764 0.228489482517385 0.82259976293955 0.666666666666667 24.2 24 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.162174544864764 0.228489482517385 0.82259976293955 0.666666666666667 24.2 24 2 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.162174544864764 0.228489482517385 0.82259976293955 0.666666666666667 24.2 24 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.162174544864764 0.228489482517385 0.82259976293955 0.666666666666667 24.2 24 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.162174544864764 0.228489482517385 0.82259976293955 0.666666666666667 24.2 24 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.162174544864764 0.228489482517385 0.82259976293955 0.666666666666667 24.2 24 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.162174544864764 0.228489482517385 0.82259976293955 0.666666666666667 24.2 24 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 5.70689657659822e-05 0.000189298690641009 0.82259976293955 0.666666666666667 24.2 24 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00250340689866215 0.00566351036056637 0.82259976293955 0.666666666666667 24.2 24 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0360742214327919 0.0613304863785698 0.82259976293955 0.666666666666667 24.2 24 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000842069706312394 0.00217866398560461 0.809114520924147 0.655737704918033 24.2 24 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.83716725390491e-11 1.79060890568952e-10 0.808083296534734 0.654901960784314 24.2 24 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000140844799890381 0.000429169486603879 0.807366433996225 0.654320987654321 24.2 24 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00299878438624767 0.00673071006566315 0.805812012675477 0.653061224489796 24.2 24 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0555333892856465 0.0899410838693477 0.802034768866061 0.65 24.2 24 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0555333892856465 0.0899410838693477 0.802034768866061 0.65 24.2 24 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.10714310898936e-19 3.66387126532992e-18 0.800165223950289 0.648484848484848 24.2 24 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0152188282565559 0.0286081804611348 0.798405652264857 0.647058823529412 24.2 24 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00446077393904096 0.0094883128778106 0.796893520347689 0.645833333333333 24.2 24 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00446077393904096 0.0094883128778106 0.796893520347689 0.645833333333333 24.2 24 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.06429478917849e-05 0.000107401268103473 0.795692294058349 0.644859813084112 24.2 24 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.11526310724751 0.168570813579863 0.793221199977423 0.642857142857143 24.2 24 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.11526310724751 0.168570813579863 0.793221199977423 0.642857142857143 24.2 24 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.11526310724751 0.168570813579863 0.793221199977423 0.642857142857143 24.2 24 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.11526310724751 0.168570813579863 0.793221199977423 0.642857142857143 24.2 24 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.11526310724751 0.168570813579863 0.793221199977423 0.642857142857143 24.2 24 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00477929464775901 0.0101054030962275 0.789695772421968 0.64 24.2 24 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 4.26068747614806e-08 2.28790878436177e-07 0.789194696424238 0.639593908629442 24.2 24 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00371338848936128 0.00809211611081332 0.785208864624116 0.636363636363636 24.2 24 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.022595254599853 0.0400411547890297 0.785208864624116 0.636363636363636 24.2 24 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0589347832947903 0.0948011481075181 0.785208864624115 0.636363636363636 24.2 24 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.169662138014343 0.238095880073383 0.785208864624115 0.636363636363636 24.2 24 2 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.169662138014343 0.238095880073383 0.785208864624115 0.636363636363636 24.2 24 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.169662138014343 0.238095880073383 0.785208864624115 0.636363636363636 24.2 24 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.169662138014343 0.238095880073383 0.785208864624115 0.636363636363636 24.2 24 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0314834368604377 0.0547688638782431 0.781469774792572 0.633333333333333 24.2 24 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0837944514626644 0.130458976401938 0.77930503857431 0.631578947368421 24.2 24 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0837944514626644 0.130458976401938 0.77930503857431 0.631578947368421 24.2 24 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00538640735739339 0.0113721923880872 0.776899776109575 0.62962962962963 24.2 24 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00305248151975433 0.00684044283875656 0.776162679547801 0.629032258064516 24.2 24 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000331257471094159 0.000915299769644638 0.774468925746278 0.627659574468085 24.2 24 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0330849939474656 0.057274873950418 0.771187277755828 0.625 24.2 24 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0330849939474656 0.057274873950418 0.771187277755828 0.625 24.2 24 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.120144258627419 0.175349005155711 0.771187277755828 0.625 24.2 24 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.120144258627419 0.175349005155711 0.771187277755828 0.625 24.2 24 2 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.25588116604667 0.326539678135441 0.771187277755828 0.625 24.2 24 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.25588116604667 0.326539678135441 0.771187277755828 0.625 24.2 24 2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.25588116604667 0.326539678135441 0.771187277755828 0.625 24.2 24 2 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 48%5605104 DISSOLUTION OF FIBRIN CLOT 0.25588116604667 0.326539678135441 0.771187277755828 0.625 24.2 24 2 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.25588116604667 0.326539678135441 0.771187277755828 0.625 24.2 24 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.25588116604667 0.326539678135441 0.771187277755828 0.625 24.2 24 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 6.20326625771958e-06 2.37931209831131e-05 0.770204873580343 0.624203821656051 24.2 24 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 7.17237508945445e-05 0.000228328629805228 0.76865879487794 0.622950819672131 24.2 24 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0138243674263592 0.0265838849293368 0.76775977874358 0.622222222222222 24.2 24 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.99735209440657e-06 1.20486780518095e-05 0.76760036018487 0.622093023255814 24.2 24 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000233459292618473 0.000668435761360336 0.762774325634855 0.618181818181818 24.2 24 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00809510457230239 0.0162472973291767 0.762774325634855 0.618181818181818 24.2 24 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0641714962500916 0.102949311345976 0.759322858098046 0.615384615384615 24.2 24 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.174199413392541 0.243502716363051 0.759322858098046 0.615384615384615 24.2 24 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.174199413392541 0.243502716363051 0.759322858098046 0.615384615384615 24.2 24 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.174199413392541 0.243502716363051 0.759322858098046 0.615384615384615 24.2 24 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0477351491350967 0.0784377796988945 0.756261072379909 0.612903225806452 24.2 24 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0898078328063071 0.134381226165484 0.751069348770893 0.608695652173913 24.2 24 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.0661565247827355 0.106014340952514 0.749153355534233 0.607142857142857 24.2 24 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0492230544822538 0.0800507503179968 0.747817966308681 0.606060606060606 24.2 24 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00409374633671081 0.00882636520778709 0.746833995300381 0.605263157894737 24.2 24 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 5.43117187114909e-05 0.00018401327553917 0.743405375824251 0.602484472049689 24.2 24 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 5.59732896352012e-05 0.000186515474596018 0.741853773939348 0.601226993865031 24.2 24 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0677990708159552 0.106253389615754 0.740339786645595 0.6 24.2 24 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0677990708159552 0.106253389615754 0.740339786645595 0.6 24.2 24 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.176815714960917 0.246917333061222 0.740339786645595 0.6 24.2 24 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0019920557392728 0.00466517081548169 0.740339786645595 0.6 24.2 24 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.256550499055111 0.326539678135441 0.740339786645595 0.6 24.2 24 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.256550499055111 0.326539678135441 0.740339786645595 0.6 24.2 24 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.256550499055111 0.326539678135441 0.740339786645595 0.6 24.2 24 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.256550499055111 0.326539678135441 0.740339786645595 0.6 24.2 24 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.256550499055111 0.326539678135441 0.740339786645595 0.6 24.2 24 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.256550499055111 0.326539678135441 0.740339786645595 0.6 24.2 24 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 7.6087481773545e-05 0.000241679657508381 0.738816453751262 0.598765432098765 24.2 24 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0387460200263531 0.0657942559636044 0.734464074053169 0.595238095238095 24.2 24 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0515897518766616 0.083803900594166 0.733670058837977 0.594594594594595 24.2 24 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.0934878428104673 0.139740756637915 0.7311997892796 0.592592592592593 24.2 24 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000186731487343214 0.000557062697042753 0.729475261474695 0.591194968553459 24.2 24 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000186731487343214 0.000557062697042753 0.729475261474695 0.591194968553459 24.2 24 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000327059015603717 0.000905457157984608 0.724418500911281 0.587096774193548 24.2 24 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0401535916539032 0.0665950593514036 0.724245443457647 0.58695652173913 24.2 24 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0308669095218733 0.0537620712969716 0.721714886352624 0.584905660377358 24.2 24 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.000131931871445223 0.000406102667286694 0.720330603222741 0.583783783783784 24.2 24 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.255225895432369 0.326539678135441 0.719774792572106 0.583333333333333 24.2 24 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.255225895432369 0.326539678135441 0.719774792572106 0.583333333333333 24.2 24 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.255225895432369 0.326539678135441 0.719774792572106 0.583333333333333 24.2 24 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.096186438596068 0.143473063021179 0.710427067993247 0.575757575757576 24.2 24 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.096186438596068 0.143473063021179 0.710427067993247 0.575757575757576 24.2 24 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.252781154919249 0.326117482729004 0.705085511091043 0.571428571428571 24.2 24 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.252781154919249 0.326117482729004 0.705085511091043 0.571428571428571 24.2 24 2 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.252781154919249 0.326117482729004 0.705085511091043 0.571428571428571 24.2 24 2 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.252781154919249 0.326117482729004 0.705085511091043 0.571428571428571 24.2 24 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00213616494669496 0.00484810641012269 0.705085511091042 0.571428571428571 24.2 24 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0967373033411656 0.143992868885438 0.700321419799887 0.567567567567568 24.2 24 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.129873230697284 0.186676370992157 0.699209798498617 0.566666666666667 24.2 24 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0555937055007171 0.0899410838693477 0.69843376098641 0.566037735849057 24.2 24 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0328788412681068 0.0571264848895188 0.697421538144401 0.565217391304348 24.2 24 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00361252115651514 0.0078843828308605 0.69515472924469 0.563380281690141 24.2 24 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0730703834714548 0.114388510098878 0.694068549980245 0.5625 24.2 24 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.24967901596113 0.32547575495344 0.694068549980245 0.5625 24.2 24 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.24967901596113 0.32547575495344 0.694068549980245 0.5625 24.2 24 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.24967901596113 0.32547575495344 0.694068549980245 0.5625 24.2 24 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.24967901596113 0.32547575495344 0.694068549980245 0.5625 24.2 24 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.000175626079628213 0.000526138760654626 0.693758836214078 0.562248995983936 24.2 24 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00460714901456825 0.00978030561425733 0.693505639558525 0.562043795620438 24.2 24 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0966119990234803 0.14395693676483 0.692187605400353 0.560975609756098 24.2 24 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0199365806755868 0.0355065760968211 0.689922381820267 0.559139784946237 24.2 24 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.00749118356208427 0.0153993909317232 0.689817911441433 0.559055118110236 24.2 24 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00589373580861265 0.0124248682306012 0.68953215422874 0.558823529411765 24.2 24 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0556206281131595 0.0899410838693477 0.687747342785525 0.557377049180328 24.2 24 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0330156916412669 0.057274873950418 0.687235244987472 0.556962025316456 24.2 24 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.24618453009483 0.322578808770666 0.685499802449625 0.555555555555556 24.2 24 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.24618453009483 0.322578808770666 0.685499802449625 0.555555555555556 24.2 24 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.24618453009483 0.322578808770666 0.685499802449625 0.555555555555556 24.2 24 2 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.373014442524051 0.465205566793799 0.685499802449625 0.555555555555556 24.2 24 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.373014442524051 0.465205566793799 0.685499802449625 0.555555555555556 24.2 24 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.373014442524051 0.465205566793799 0.685499802449625 0.555555555555556 24.2 24 2 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.373014442524051 0.465205566793799 0.685499802449625 0.555555555555556 24.2 24 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.373014442524051 0.465205566793799 0.685499802449625 0.555555555555556 24.2 24 2 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.373014442524051 0.465205566793799 0.685499802449625 0.555555555555556 24.2 24 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00749669640447134 0.0153993909317232 0.684499072811012 0.554744525547445 24.2 24 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.173291725411026 0.24294987710334 0.680772217605145 0.551724137931034 24.2 24 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.242458355453187 0.318576398716422 0.678644804425128 0.55 24.2 24 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.242458355453187 0.318576398716422 0.678644804425128 0.55 24.2 24 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.242458355453187 0.318576398716422 0.678644804425128 0.55 24.2 24 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0412792344104532 0.067986516858883 0.673036169677813 0.545454545454545 24.2 24 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.360816532304034 0.452770657379753 0.673036169677813 0.545454545454545 24.2 24 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00894833511445455 0.0174431244765326 0.669616270441646 0.542682926829268 24.2 24 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.230741787825258 0.31122802282023 0.66440750083579 0.538461538461538 24.2 24 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.079812437524866 0.124531906357329 0.653240988216701 0.529411764705882 24.2 24 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.079812437524866 0.124531906357329 0.653240988216701 0.529411764705882 24.2 24 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.321380025139708 0.407233994455748 0.649420865478592 0.526315789473684 24.2 24 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.313111685984254 0.397110453792864 0.646328385166789 0.523809523809524 24.2 24 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.190509399009398 0.26577928901017 0.642656064796523 0.520833333333333 24.2 24 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.290867568810907 0.369557634301715 0.63979981561965 0.518518518518518 24.2 24 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0351170395335457 0.0597745780576979 0.62420805540707 0.505882352941176 24.2 24 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.149585342214659 0.212822131250231 0.623310129650071 0.505154639175258 24.2 24 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.278474120645053 0.354127501052645 0.616949822204662 0.5 24.2 24 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.375928447058133 0.468429229565432 0.616949822204662 0.5 24.2 24 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.4664071691757 0.546702966834449 0.616949822204662 0.5 24.2 24 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.4664071691757 0.546702966834449 0.616949822204662 0.5 24.2 24 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.414174149584296 0.507639806079633 0.616949822204662 0.5 24.2 24 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.429518585210696 0.51753170766708 0.616949822204662 0.5 24.2 24 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.429518585210696 0.51753170766708 0.616949822204662 0.5 24.2 24 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.446732427371755 0.525934483573108 0.616949822204662 0.5 24.2 24 2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.489478385992992 0.569523911094053 0.616949822204662 0.5 24.2 24 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.489478385992992 0.569523911094053 0.616949822204662 0.5 24.2 24 2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.489478385992992 0.569523911094053 0.616949822204662 0.5 24.2 24 2 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.489478385992992 0.569523911094053 0.616949822204662 0.5 24.2 24 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.489478385992992 0.569523911094053 0.616949822204662 0.5 24.2 24 2 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.489478385992992 0.569523911094053 0.616949822204662 0.5 24.2 24 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.489478385992992 0.569523911094053 0.616949822204662 0.5 24.2 24 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.297451001823159 0.377584991609594 0.606126141113352 0.491228070175439 24.2 24 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.357764377896395 0.452532186441395 0.601902265565524 0.48780487804878 24.2 24 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.447949820162057 0.525934483573108 0.592271829316476 0.48 24.2 24 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.369645987510577 0.46344162134586 0.587571259242535 0.476190476190476 24.2 24 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.479565339228025 0.561663767672 0.587571259242535 0.476190476190476 24.2 24 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.497688861584427 0.577660073437716 0.584478778930733 0.473684210526316 24.2 24 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.497688861584427 0.577660073437716 0.584478778930733 0.473684210526316 24.2 24 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.349474168255258 0.442439271732413 0.581356563231316 0.471153846153846 24.2 24 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.517820136651704 0.59955903535832 0.580658656192623 0.470588235294118 24.2 24 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.487102307110345 0.569523911094053 0.575819834057685 0.466666666666667 24.2 24 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.540474350809367 0.624772543624475 0.575819834057685 0.466666666666667 24.2 24 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.518990696387387 0.600425821918091 0.569492143573534 0.461538461538462 24.2 24 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.566393207487297 0.649458125910092 0.569492143573534 0.461538461538462 24.2 24 2 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.566393207487297 0.649458125910092 0.569492143573534 0.461538461538462 24.2 24 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.492383711467761 0.57243629200868 0.569492143573534 0.461538461538462 24.2 24 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.109585213511618 0.161094792176687 0.56879764095942 0.460975609756098 24.2 24 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.596696597400456 0.682555673714509 0.560863474731511 0.454545454545455 24.2 24 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.596696597400456 0.682555673714509 0.560863474731511 0.454545454545455 24.2 24 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.551562787717668 0.635961310149214 0.557245000700985 0.451612903225806 24.2 24 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.568699003006516 0.651577038066242 0.55312742680418 0.448275862068966 24.2 24 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.606646008838332 0.688402927094854 0.542915843540103 0.44 24.2 24 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.626773279608331 0.71067599751606 0.539831094429079 0.4375 24.2 24 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.627806476653155 0.711280745443821 0.536478106264924 0.434782608695652 24.2 24 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.714815088656964 0.792197718971075 0.523472576416077 0.424242424242424 24.2 24 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.779737304625404 0.852201370569854 0.523127959841741 0.423963133640553 24.2 24 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.706103722306952 0.783153232145591 0.521366046933517 0.422535211267606 24.2 24 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.827943641687917 0.89164644613069 0.520000564429644 0.421428571428571 24.2 24 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.688537473676427 0.771946070478241 0.517441786365201 0.419354838709677 24.2 24 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.689760474703854 0.771946070478241 0.514124851837219 0.416666666666667 24.2 24 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.912426384877349 0.962477943425105 0.512004749355416 0.414948453608247 24.2 24 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.70304047967797 0.780363964572349 0.508076324168545 0.411764705882353 24.2 24 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.721912624031581 0.798198651124273 0.508076324168545 0.411764705882353 24.2 24 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.716170826484813 0.792465852323397 0.50477712725836 0.409090909090909 24.2 24 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.716170826484813 0.792465852323397 0.50477712725836 0.409090909090909 24.2 24 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.799955479618446 0.873627511509631 0.487820789650198 0.395348837209302 24.2 24 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.836648770529292 0.895151278543746 0.485468712554488 0.39344262295082 24.2 24 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.864978137093714 0.920607590443548 0.484188468059355 0.392405063291139 24.2 24 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.838249419020833 0.896190024993723 0.478450882526065 0.387755102040816 24.2 24 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.766865016714202 0.841363854112806 0.474576786311279 0.384615384615385 24.2 24 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.985559764094929 1 0.455701573219353 0.369318181818182 24.2 24 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.859367165742076 0.916701257009726 0.452429869616752 0.366666666666667 24.2 24 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.993753184939823 1 0.444469226749595 0.360215053763441 24.2 24 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.860939000309248 0.917690035535625 0.444203871987357 0.36 24.2 24 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.828379585681006 0.89164644613069 0.440678444431902 0.357142857142857 24.2 24 2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.828379585681006 0.89164644613069 0.440678444431902 0.357142857142857 24.2 24 2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.828379585681006 0.89164644613069 0.440678444431902 0.357142857142857 24.2 24 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.828379585681006 0.89164644613069 0.440678444431902 0.357142857142857 24.2 24 2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.828379585681006 0.89164644613069 0.440678444431902 0.357142857142857 24.2 24 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.865616975413539 0.920607590443548 0.431864875543263 0.35 24.2 24 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.923234671270025 0.973157731272034 0.423051306654625 0.342857142857143 24.2 24 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.949472418181373 0.9927253865335 0.420050942777642 0.340425531914894 24.2 24 2 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.875945168313002 0.930896172150413 0.411299881469775 0.333333333333333 24.2 24 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.939395920574445 0.985085036829355 0.396610599988711 0.321428571428571 24.2 24 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.958896034271427 1 0.385593638877914 0.3125 24.2 24 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.983734382861889 1 0.352542755545521 0.285714285714286 24.2 24 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.341886551347672 0.277078085642317 24.2 24 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.99622351762181 1 0.334181153694192 0.270833333333333 24.2 24 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.990963861638057 1 0.318425714686277 0.258064516129032 24.2 24 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.990963861638057 1 0.318425714686277 0.258064516129032 24.2 24 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.29229810744597 0.236889692585895 24.2 24 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.997930495704084 1 0.292239389465366 0.236842105263158 24.2 24 2 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.994186230611364 1 0.268239053132462 0.217391304347826 24.2 24 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.99999990493814 1 0.262774924272356 0.212962962962963 24.2 24 2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.999231186571733 1 0.238819286014708 0.193548387096774 24.2 24 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.999231186571733 1 0.238819286014708 0.193548387096774 24.2 24 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999941895926435 1 0.236278655312424 0.191489361702128 24.2 24 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999939138557 1 0.233069932832872 0.188888888888889 24.2 24 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0298524107518385 0.0241935483870968 24.2 24 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 2.39667788446863e-05 0.000151576561315505 2.77941176470588 1 25.1 25 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 2.39667788446863e-05 0.000151576561315505 2.77941176470588 1 25.1 25 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 3.60380065302446e-10 8.14001322103779e-09 2.52673796791444 0.909090909090909 25.1 25 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 1.40012762698352e-05 9.09763293697512e-05 2.52673796791444 0.909090909090909 25.1 25 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 4.82925697043955e-05 0.000287532747654204 2.50147058823529 0.9 25.1 25 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.000165003032793792 0.000804107245430019 2.47058823529412 0.888888888888889 25.1 25 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.000557291072404487 0.00235658344228634 2.43198529411765 0.875 25.1 25 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 6.0941408844534e-06 4.4244706523353e-05 2.38235294117647 0.857142857142857 25.1 25 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00185514347011985 0.00636113050115795 2.38235294117647 0.857142857142857 25.1 25 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00185514347011985 0.00636113050115795 2.38235294117647 0.857142857142857 25.1 25 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00185514347011985 0.00636113050115795 2.38235294117647 0.857142857142857 25.1 25 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00185514347011985 0.00636113050115795 2.38235294117647 0.857142857142857 25.1 25 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 6.38699152947624e-05 0.000363547557857788 2.31617647058824 0.833333333333333 25.1 25 1 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0060610061489082 0.0178938003109883 2.31617647058824 0.833333333333333 25.1 25 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.38181057546853e-06 1.95658004201235e-05 2.28892733564014 0.823529411764706 25.1 25 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.000202603390159916 0.000964229512366423 2.27406417112299 0.818181818181818 25.1 25 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.000631844885151378 0.00258366457347819 2.22352941176471 0.8 25.1 25 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000631844885151378 0.00258366457347819 2.22352941176471 0.8 25.1 25 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.000631844885151378 0.00258366457347819 2.22352941176471 0.8 25.1 25 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.48277303236285e-08 4.7822504872511e-07 2.22352941176471 0.8 25.1 25 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 7.02848040134108e-05 0.00039068467230892 2.18382352941176 0.785714285714286 25.1 25 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 7.02848040134108e-05 0.00039068467230892 2.18382352941176 0.785714285714286 25.1 25 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00193029921104192 0.00655564624656959 2.16176470588235 0.777777777777778 25.1 25 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00193029921104192 0.00655564624656959 2.16176470588235 0.777777777777778 25.1 25 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00193029921104192 0.00655564624656959 2.16176470588235 0.777777777777778 25.1 25 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000210605356332252 0.000989080600860707 2.13800904977376 0.769230769230769 25.1 25 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.000210605356332252 0.000989080600860707 2.13800904977376 0.769230769230769 25.1 25 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.000210605356332252 0.000989080600860707 2.13800904977376 0.769230769230769 25.1 25 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000618803814755378 0.00257451999449755 2.08455882352941 0.75 25.1 25 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00574870066326596 0.017078081511122 2.08455882352941 0.75 25.1 25 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 2.73687519073162e-06 2.18796258225342e-05 2.05434782608696 0.739130434782609 25.1 25 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000200140281816936 0.000955703426260069 2.03823529411765 0.733333333333333 25.1 25 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000200140281816936 0.000955703426260069 2.03823529411765 0.733333333333333 25.1 25 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00177648887179527 0.00616571625503579 2.02139037433155 0.727272727272727 25.1 25 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00177648887179527 0.00616571625503579 2.02139037433155 0.727272727272727 25.1 25 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.000561406737129354 0.00235658344228634 1.98529411764706 0.714285714285714 25.1 25 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.000561406737129354 0.00235658344228634 1.98529411764706 0.714285714285714 25.1 25 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.000561406737129354 0.00235658344228634 1.98529411764706 0.714285714285714 25.1 25 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0165756628458791 0.0424994022156504 1.98529411764706 0.714285714285714 25.1 25 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0165756628458791 0.0424994022156504 1.98529411764706 0.714285714285714 25.1 25 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0165756628458791 0.0424994022156504 1.98529411764706 0.714285714285714 25.1 25 1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0165756628458791 0.0424994022156504 1.98529411764706 0.714285714285714 25.1 25 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0165756628458791 0.0424994022156504 1.98529411764706 0.714285714285714 25.1 25 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 5.83887068962549e-05 0.000335028749650688 1.94558823529412 0.7 25.1 25 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 5.83887068962549e-05 0.000335028749650688 1.94558823529412 0.7 25.1 25 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0049600259714532 0.0149853863213968 1.94558823529412 0.7 25.1 25 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 6.27591751563627e-06 4.53331503794437e-05 1.92420814479638 0.692307692307692 25.1 25 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00153725034620741 0.00544156030510732 1.92420814479638 0.692307692307692 25.1 25 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000486711549474297 0.00210513840395722 1.91084558823529 0.6875 25.1 25 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000486711549474297 0.00210513840395722 1.91084558823529 0.6875 25.1 25 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 4.23499777609492e-11 1.28221315646448e-09 1.90170278637771 0.684210526315789 25.1 25 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.92183006794372e-08 2.79057570069788e-07 1.85294117647059 0.666666666666667 25.1 25 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 5.14349679902182e-07 5.11831884266298e-06 1.85294117647059 0.666666666666667 25.1 25 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000132365208589012 0.00066556781562602 1.85294117647059 0.666666666666667 25.1 25 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000409789477102912 0.00180535735578156 1.85294117647059 0.666666666666667 25.1 25 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.000409789477102912 0.00180535735578156 1.85294117647059 0.666666666666667 25.1 25 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.000409789477102912 0.00180535735578156 1.85294117647059 0.666666666666667 25.1 25 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00409185898587505 0.0126306189520612 1.85294117647059 0.666666666666667 25.1 25 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00409185898587505 0.0126306189520612 1.85294117647059 0.666666666666667 25.1 25 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00409185898587505 0.0126306189520612 1.85294117647059 0.666666666666667 25.1 25 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00409185898587505 0.0126306189520612 1.85294117647059 0.666666666666667 25.1 25 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00409185898587505 0.0126306189520612 1.85294117647059 0.666666666666667 25.1 25 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00409185898587505 0.0126306189520612 1.85294117647059 0.666666666666667 25.1 25 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00409185898587505 0.0126306189520612 1.85294117647059 0.666666666666667 25.1 25 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.013385503567714 0.0354044081354219 1.85294117647059 0.666666666666667 25.1 25 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 2.80802244253367e-11 8.68655638201178e-10 1.85294117647059 0.666666666666667 25.1 25 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00128393964775419 0.0045905681375734 1.85294117647059 0.666666666666667 25.1 25 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00128393964775419 0.0045905681375734 1.85294117647059 0.666666666666667 25.1 25 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.85526334733985e-09 3.52005299101948e-08 1.83546059933407 0.660377358490566 25.1 25 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.88422601473946e-08 6.43542001756875e-07 1.83188502673797 0.659090909090909 25.1 25 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 3.93771909852449e-06 2.98051823255338e-05 1.82398897058824 0.65625 25.1 25 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 3.60806137083555e-05 0.000220354992733862 1.81730769230769 0.653846153846154 25.1 25 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 3.60806137083555e-05 0.000220354992733862 1.81730769230769 0.653846153846154 25.1 25 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 3.60806137083555e-05 0.000220354992733862 1.81730769230769 0.653846153846154 25.1 25 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000110076635411441 0.00057966237902859 1.81265984654731 0.652173913043478 25.1 25 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000338216812819633 0.0015278810306106 1.80661764705882 0.65 25.1 25 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000338216812819633 0.0015278810306106 1.80661764705882 0.65 25.1 25 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000338216812819633 0.0015278810306106 1.80661764705882 0.65 25.1 25 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000338216812819633 0.0015278810306106 1.80661764705882 0.65 25.1 25 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.64985373151346e-13 7.33669331232391e-12 1.79844290657439 0.647058823529412 25.1 25 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 3.2841352492302e-06 2.55764353277928e-05 1.79844290657439 0.647058823529412 25.1 25 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00104885595033761 0.00388677608679798 1.79844290657439 0.647058823529412 25.1 25 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00104885595033761 0.00388677608679798 1.79844290657439 0.647058823529412 25.1 25 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00104885595033761 0.00388677608679798 1.79844290657439 0.647058823529412 25.1 25 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00329376884254791 0.0104388264208144 1.78676470588235 0.642857142857143 25.1 25 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 9.03220646525255e-05 0.000490566022902839 1.77882352941176 0.64 25.1 25 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.71390576716591e-06 2.18185757439384e-05 1.77573529411765 0.638888888888889 25.1 25 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 8.50371316359956e-08 1.0708658258232e-06 1.77409261576971 0.638297872340426 25.1 25 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0105312158958546 0.0289863060344314 1.76871657754011 0.636363636363636 25.1 25 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.0105312158958546 0.0289863060344314 1.76871657754011 0.636363636363636 25.1 25 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0105312158958546 0.0289863060344314 1.76871657754011 0.636363636363636 25.1 25 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0105312158958546 0.0289863060344314 1.76871657754011 0.636363636363636 25.1 25 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 7.67155566496798e-10 1.60538583988962e-08 1.76470588235294 0.634920634920635 25.1 25 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000844293933903157 0.00319529326580902 1.75541795665635 0.631578947368421 25.1 25 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 2.07130764611668e-07 2.28205064426971e-06 1.7522378516624 0.630434782608696 25.1 25 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 7.33574100147863e-05 0.000404603079267601 1.75 0.62962962962963 25.1 25 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000221645332720387 0.00102736582560622 1.73713235294118 0.625 25.1 25 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000221645332720387 0.00102736582560622 1.73713235294118 0.625 25.1 25 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000221645332720387 0.00102736582560622 1.73713235294118 0.625 25.1 25 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000221645332720387 0.00102736582560622 1.73713235294118 0.625 25.1 25 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00261265314488735 0.00852707666324473 1.73713235294118 0.625 25.1 25 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00261265314488735 0.00852707666324473 1.73713235294118 0.625 25.1 25 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.034620599816901 0.0785727488667466 1.73713235294118 0.625 25.1 25 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.98554533927492e-07 4.996078181541e-06 1.72941176470588 0.622222222222222 25.1 25 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 5.3727829378167e-06 3.92075390795547e-05 1.72774244833068 0.621621621621622 25.1 25 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.46932919608007e-06 1.38467248080923e-05 1.72058823529412 0.619047619047619 25.1 25 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000672725669694389 0.00273511036564319 1.72058823529412 0.619047619047619 25.1 25 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000672725669694389 0.00273511036564319 1.72058823529412 0.619047619047619 25.1 25 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.03837173294698e-07 4.256742945173e-06 1.71495619524405 0.617021276595745 25.1 25 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 7.64160328455081e-12 2.78820550613226e-10 1.71289329685363 0.616279069767442 25.1 25 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.000177108386163198 0.000857228685408947 1.710407239819 0.615384615384615 25.1 25 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000177108386163198 0.000857228685408947 1.710407239819 0.615384615384615 25.1 25 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00817923280934332 0.0230020717148133 1.710407239819 0.615384615384615 25.1 25 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00817923280934332 0.0230020717148133 1.710407239819 0.615384615384615 25.1 25 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00817923280934332 0.0230020717148133 1.710407239819 0.615384615384615 25.1 25 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 8.56477796004357e-09 1.28291358285705e-07 1.70351043643264 0.612903225806452 25.1 25 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 3.25767005228939e-07 3.48546201835174e-06 1.70168067226891 0.612244897959184 25.1 25 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.00205310326542072 0.00690677528769192 1.69852941176471 0.611111111111111 25.1 25 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00205310326542072 0.00690677528769192 1.69852941176471 0.611111111111111 25.1 25 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00205310326542072 0.00690677528769192 1.69852941176471 0.611111111111111 25.1 25 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000532113056686894 0.00226705652594446 1.69181585677749 0.608695652173913 25.1 25 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 7.23032599977106e-08 9.18638740863769e-07 1.6875 0.607142857142857 25.1 25 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000140672125851327 0.000697478867896998 1.6875 0.607142857142857 25.1 25 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.24337112858354e-09 2.52759587996339e-08 1.67526188557615 0.602739726027397 25.1 25 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 8.40083934624759e-16 6.29178652090017e-14 1.66764705882353 0.6 25.1 25 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 8.11026949538382e-06 5.77045674596559e-05 1.66764705882353 0.6 25.1 25 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.00160340961552845 0.00563370835283206 1.66764705882353 0.6 25.1 25 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0260237199621052 0.0620297378661235 1.66764705882353 0.6 25.1 25 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0260237199621052 0.0620297378661235 1.66764705882353 0.6 25.1 25 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.0260237199621052 0.0620297378661235 1.66764705882353 0.6 25.1 25 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0260237199621052 0.0620297378661235 1.66764705882353 0.6 25.1 25 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0260237199621052 0.0620297378661235 1.66764705882353 0.6 25.1 25 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0260237199621052 0.0620297378661235 1.66764705882353 0.6 25.1 25 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 6.0799513087422e-07 5.92587035091791e-06 1.66764705882353 0.6 25.1 25 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000111207188668169 0.00057966237902859 1.66764705882353 0.6 25.1 25 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000111207188668169 0.00057966237902859 1.66764705882353 0.6 25.1 25 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.000111207188668169 0.00057966237902859 1.66764705882353 0.6 25.1 25 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00041863023482218 0.00183861365479001 1.66764705882353 0.6 25.1 25 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00630851263473849 0.0182459623561644 1.66764705882353 0.6 25.1 25 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00630851263473849 0.0182459623561644 1.66764705882353 0.6 25.1 25 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00630851263473849 0.0182459623561644 1.66764705882353 0.6 25.1 25 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00630851263473849 0.0182459623561644 1.66764705882353 0.6 25.1 25 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00630851263473849 0.0182459623561644 1.66764705882353 0.6 25.1 25 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00630851263473849 0.0182459623561644 1.66764705882353 0.6 25.1 25 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00630851263473849 0.0182459623561644 1.66764705882353 0.6 25.1 25 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.02724099284037e-08 1.52267076334567e-07 1.65935030728709 0.597014925373134 25.1 25 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.92162314042536e-15 1.24294078582967e-13 1.65902872777018 0.596899224806202 25.1 25 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 6.42927478461599e-06 4.62063536288311e-05 1.65441176470588 0.595238095238095 25.1 25 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 8.18765872667801e-09 1.23947216681519e-07 1.65153452685422 0.594202898550725 25.1 25 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.94544085943549e-08 4.10917876762421e-07 1.65027573529412 0.59375 25.1 25 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000328018896924523 0.00150087102997941 1.64705882352941 0.592592592592593 25.1 25 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0012468986163677 0.00450339271850567 1.64237967914439 0.590909090909091 25.1 25 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0012468986163677 0.00450339271850567 1.64237967914439 0.590909090909091 25.1 25 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.20823018562607e-10 7.36340573249338e-09 1.63494809688581 0.588235294117647 25.1 25 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.20823018562607e-10 7.36340573249338e-09 1.63494809688581 0.588235294117647 25.1 25 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.20823018562607e-10 7.36340573249338e-09 1.63494809688581 0.588235294117647 25.1 25 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 6.87745808168283e-05 0.000385300112213963 1.63494809688581 0.588235294117647 25.1 25 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.15617121962337e-06 2.48856102426802e-05 1.62132352941176 0.583333333333333 25.1 25 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 5.3871512127255e-05 0.00031808780812068 1.62132352941176 0.583333333333333 25.1 25 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.000966767870239997 0.00361078918464965 1.62132352941176 0.583333333333333 25.1 25 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0195463155698259 0.0480086518902578 1.62132352941176 0.583333333333333 25.1 25 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0195463155698259 0.0480086518902578 1.62132352941176 0.583333333333333 25.1 25 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0195463155698259 0.0480086518902578 1.62132352941176 0.583333333333333 25.1 25 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0195463155698259 0.0480086518902578 1.62132352941176 0.583333333333333 25.1 25 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0195463155698259 0.0480086518902578 1.62132352941176 0.583333333333333 25.1 25 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.80790803114603e-17 2.21980729351156e-15 1.61553308823529 0.58125 25.1 25 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.23556064202447e-07 4.39941809751885e-06 1.60169491525424 0.576271186440678 25.1 25 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.23556064202447e-07 4.39941809751885e-06 1.60169491525424 0.576271186440678 25.1 25 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.38521162766503e-21 1.97115614616734e-19 1.60147058823529 0.576190476190476 25.1 25 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.03808086344021e-08 2.92948390775295e-07 1.59911361804996 0.575342465753425 25.1 25 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000120607816975489 0.000621306790968493 1.58823529411765 0.571428571428571 25.1 25 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000120607816975489 0.000621306790968493 1.58823529411765 0.571428571428571 25.1 25 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00284432154330719 0.00913650012669556 1.58823529411765 0.571428571428571 25.1 25 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00284432154330719 0.00913650012669556 1.58823529411765 0.571428571428571 25.1 25 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000577814591688783 0.0024183240116857 1.58823529411765 0.571428571428571 25.1 25 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0146931847650705 0.0383640402214593 1.58823529411765 0.571428571428571 25.1 25 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0146931847650705 0.0383640402214593 1.58823529411765 0.571428571428571 25.1 25 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.29633326153959e-06 3.21772749008991e-05 1.58044982698962 0.568627450980392 25.1 25 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.29633326153959e-06 3.21772749008991e-05 1.58044982698962 0.568627450980392 25.1 25 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.65517701712635e-14 2.26144212842209e-12 1.57966567922133 0.568345323741007 25.1 25 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.59540764820048e-07 1.88267062256579e-06 1.57638279192274 0.567164179104478 25.1 25 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.59540764820048e-07 1.88267062256579e-06 1.57638279192274 0.567164179104478 25.1 25 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.33477884878924e-10 5.7282591410812e-09 1.57219251336898 0.565656565656566 25.1 25 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.24709592462624e-07 1.52984267305444e-06 1.57097186700767 0.565217391304348 25.1 25 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00217611984395275 0.00718472978641476 1.57097186700767 0.565217391304348 25.1 25 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00217611984395275 0.00718472978641476 1.57097186700767 0.565217391304348 25.1 25 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00217611984395275 0.00718472978641476 1.57097186700767 0.565217391304348 25.1 25 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 9.74123928124409e-08 1.21594592080793e-06 1.56586578293289 0.563380281690141 25.1 25 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000343767381609866 0.00154315767833072 1.56341911764706 0.5625 25.1 25 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0110603319788328 0.0301510582488105 1.56341911764706 0.5625 25.1 25 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0110603319788328 0.0301510582488105 1.56341911764706 0.5625 25.1 25 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0110603319788328 0.0301510582488105 1.56341911764706 0.5625 25.1 25 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0110603319788328 0.0301510582488105 1.56341911764706 0.5625 25.1 25 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0110603319788328 0.0301510582488105 1.56341911764706 0.5625 25.1 25 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 5.61410615079654e-05 0.00032475093709689 1.55918220946915 0.560975609756098 25.1 25 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 5.61410615079654e-05 0.00032475093709689 1.55918220946915 0.560975609756098 25.1 25 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 5.61410615079654e-05 0.00032475093709689 1.55918220946915 0.560975609756098 25.1 25 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0016643975880445 0.0058049945288905 1.55647058823529 0.56 25.1 25 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0016643975880445 0.0058049945288905 1.55647058823529 0.56 25.1 25 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.77186462868594e-09 3.40724779272986e-08 1.55407969639469 0.559139784946237 25.1 25 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 4.34453416872187e-05 0.000259759332860976 1.55129958960328 0.558139534883721 25.1 25 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.38333591010652e-09 2.72381660626955e-08 1.55061919504644 0.557894736842105 25.1 25 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 7.25967075518586e-06 5.19121180132134e-05 1.55005656108597 0.557692307692308 25.1 25 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.31614692538157e-12 2.73970449337315e-10 1.54918032786885 0.557377049180328 25.1 25 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.85362377065034e-09 8.7426666147284e-08 1.54411764705882 0.555555555555556 25.1 25 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.63203596413756e-07 1.88811965607134e-06 1.54411764705882 0.555555555555556 25.1 25 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 3.36033026907193e-05 0.00020790217273432 1.54411764705882 0.555555555555556 25.1 25 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00127292735194339 0.00457418086317033 1.54411764705882 0.555555555555556 25.1 25 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00127292735194339 0.00457418086317033 1.54411764705882 0.555555555555556 25.1 25 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00833858147670192 0.0233119871146303 1.54411764705882 0.555555555555556 25.1 25 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00833858147670192 0.0233119871146303 1.54411764705882 0.555555555555556 25.1 25 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0611644701283847 0.122071586245009 1.54411764705882 0.555555555555556 25.1 25 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.75640485952136e-07 5.64921663110269e-06 1.53489903424056 0.552238805970149 25.1 25 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.38248473389819e-06 2.60177068991196e-05 1.53346855983773 0.551724137931034 25.1 25 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.38248473389819e-06 2.60177068991196e-05 1.53346855983773 0.551724137931034 25.1 25 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 5.959578858269e-08 7.78025753698787e-07 1.52867647058824 0.55 25.1 25 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000120943064721204 0.000621306790968493 1.52867647058824 0.55 25.1 25 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00629631290603715 0.0182459623561644 1.52867647058824 0.55 25.1 25 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00629631290603715 0.0182459623561644 1.52867647058824 0.55 25.1 25 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00629631290603715 0.0182459623561644 1.52867647058824 0.55 25.1 25 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.38977032875233e-09 2.72381660626955e-08 1.52867647058824 0.55 25.1 25 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.62028008622019e-06 2.11855600152916e-05 1.52867647058824 0.55 25.1 25 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.36643213070361e-23 5.98804115248905e-21 1.52254541522491 0.547794117647059 25.1 25 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 5.06541511597241e-14 3.00336904584531e-12 1.5224803297115 0.547770700636943 25.1 25 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.32917155258421e-19 3.3838650852338e-17 1.52057504616196 0.547085201793722 25.1 25 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.08479679378118e-07 2.28205064426971e-06 1.51941176470588 0.546666666666667 25.1 25 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.79015733886397e-08 3.93108306257765e-07 1.51898084815321 0.546511627906977 25.1 25 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 5.08300871935893e-10 1.11278790886889e-08 1.51838235294118 0.546296296296296 25.1 25 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.16544837803024e-08 3.08143304193704e-07 1.51604278074866 0.545454545454545 25.1 25 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 9.25583447830665e-06 6.2719297441097e-05 1.51604278074866 0.545454545454545 25.1 25 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00476122905563458 0.0145079848954347 1.51604278074866 0.545454545454545 25.1 25 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00476122905563458 0.0145079848954347 1.51604278074866 0.545454545454545 25.1 25 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0446147248416059 0.0964844277349623 1.51604278074866 0.545454545454545 25.1 25 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.38479899796557e-10 5.75181182051697e-09 1.51160990712074 0.543859649122807 25.1 25 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 5.51474940736231e-05 0.000322941909739777 1.51054987212276 0.543478260869565 25.1 25 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 5.51474940736231e-05 0.000322941909739777 1.51054987212276 0.543478260869565 25.1 25 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.000436230602925279 0.00191001891680822 1.50882352941176 0.542857142857143 25.1 25 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00360535399470418 0.0113756512959292 1.50551470588235 0.541666666666667 25.1 25 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00360535399470418 0.0113756512959292 1.50551470588235 0.541666666666667 25.1 25 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 5.63399788895773e-07 5.56748541387976e-06 1.50551470588235 0.541666666666667 25.1 25 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.32918319811476e-13 6.10137964812035e-12 1.50332963374029 0.540880503144654 25.1 25 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 6.07925831285868e-09 1.08134807239974e-07 1.5031512605042 0.540816326530612 25.1 25 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 6.7308912889354e-11 1.84193428926059e-09 1.5017789373814 0.540322580645161 25.1 25 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 6.7308912889354e-11 1.84193428926059e-09 1.5017789373814 0.540322580645161 25.1 25 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 6.7308912889354e-11 1.84193428926059e-09 1.5017789373814 0.540322580645161 25.1 25 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 6.7308912889354e-11 1.84193428926059e-09 1.5017789373814 0.540322580645161 25.1 25 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.51301689673516e-08 6.00189069537769e-07 1.50152129817444 0.540229885057471 25.1 25 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.28916912507806e-06 2.55764353277928e-05 1.5 0.53968253968254 25.1 25 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.3708554049342e-07 3.57964719494131e-06 1.49941950464396 0.539473684210526 25.1 25 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.49510928091437e-08 4.7822504872511e-07 1.49900859220093 0.539325842696629 25.1 25 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.83141740601921e-09 5.16552175482735e-08 1.49660633484163 0.538461538461538 25.1 25 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.53903288238797e-06 2.06459645236462e-05 1.49660633484163 0.538461538461538 25.1 25 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00273355352878578 0.00884056061695947 1.49660633484163 0.538461538461538 25.1 25 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00273355352878578 0.00884056061695947 1.49660633484163 0.538461538461538 25.1 25 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00273355352878578 0.00884056061695947 1.49660633484163 0.538461538461538 25.1 25 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00273355352878578 0.00884056061695947 1.49660633484163 0.538461538461538 25.1 25 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0328079121237222 0.0765338671345192 1.49660633484163 0.538461538461538 25.1 25 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.12947321758523e-13 8.91247173124641e-12 1.49393382352941 0.5375 25.1 25 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.79069109860516e-10 4.47044461985112e-09 1.4930724355858 0.537190082644628 25.1 25 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.79069109860516e-10 4.47044461985112e-09 1.4930724355858 0.537190082644628 25.1 25 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000195976963178637 0.000942146008794595 1.49139167862267 0.536585365853659 25.1 25 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.51279107428051e-06 1.40699457431448e-05 1.49040920716113 0.536231884057971 25.1 25 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.51279107428051e-06 1.40699457431448e-05 1.49040920716113 0.536231884057971 25.1 25 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00207498053685258 0.00694752306809699 1.48897058823529 0.535714285714286 25.1 25 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00207498053685258 0.00694752306809699 1.48897058823529 0.535714285714286 25.1 25 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 7.20413202793354e-08 9.18638740863769e-07 1.48445855614973 0.534090909090909 25.1 25 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 8.83117476969865e-06 6.01280463984745e-05 1.48235294117647 0.533333333333333 25.1 25 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 8.83117476969865e-06 6.01280463984745e-05 1.48235294117647 0.533333333333333 25.1 25 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 8.83117476969865e-06 6.01280463984745e-05 1.48235294117647 0.533333333333333 25.1 25 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 8.83117476969865e-06 6.01280463984745e-05 1.48235294117647 0.533333333333333 25.1 25 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 8.83117476969865e-06 6.01280463984745e-05 1.48235294117647 0.533333333333333 25.1 25 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 8.83117476969865e-06 6.01280463984745e-05 1.48235294117647 0.533333333333333 25.1 25 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 8.83117476969865e-06 6.01280463984745e-05 1.48235294117647 0.533333333333333 25.1 25 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00157676147933735 0.00555379105222043 1.48235294117647 0.533333333333333 25.1 25 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00157676147933735 0.00555379105222043 1.48235294117647 0.533333333333333 25.1 25 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0242756671997357 0.058549617669871 1.48235294117647 0.533333333333333 25.1 25 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 4.30518920007701e-08 5.77951342614111e-07 1.48033887468031 0.532608695652174 25.1 25 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 3.1986958014699e-07 3.44829100416036e-06 1.47549019607843 0.530864197530864 25.1 25 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 6.77264388113185e-05 0.000380927756634412 1.47478991596639 0.530612244897959 25.1 25 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 6.77264388113185e-05 0.000380927756634412 1.47478991596639 0.530612244897959 25.1 25 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.90572083618522e-07 2.11862558585278e-06 1.47145328719723 0.529411764705882 25.1 25 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.90572083618522e-07 2.11862558585278e-06 1.47145328719723 0.529411764705882 25.1 25 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.90572083618522e-07 2.11862558585278e-06 1.47145328719723 0.529411764705882 25.1 25 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.90572083618522e-07 2.11862558585278e-06 1.47145328719723 0.529411764705882 25.1 25 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.90572083618522e-07 2.11862558585278e-06 1.47145328719723 0.529411764705882 25.1 25 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 5.19657329966093e-05 0.000308113491892396 1.47145328719723 0.529411764705882 25.1 25 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000913100563333223 0.00341932132006099 1.47145328719723 0.529411764705882 25.1 25 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0180507251757808 0.046032584095226 1.47145328719723 0.529411764705882 25.1 25 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0180507251757808 0.046032584095226 1.47145328719723 0.529411764705882 25.1 25 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 5.78534941258848e-10 1.22873913643484e-08 1.47010209042295 0.528925619834711 25.1 25 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.39244502677546e-06 1.95658004201235e-05 1.46911764705882 0.528571428571429 25.1 25 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000695750937801777 0.00280468437533124 1.46691176470588 0.527777777777778 25.1 25 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0134756541216403 0.0355767269296738 1.46284829721362 0.526315789473684 25.1 25 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 5.72986159172141e-11 1.69866521771241e-09 1.45969107067287 0.525179856115108 25.1 25 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000404856924613072 0.00180034813663876 1.45919117647059 0.525 25.1 25 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.01875109662416e-19 3.30437139268937e-17 1.45892494929006 0.524904214559387 25.1 25 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.38744878357487e-05 9.05660375700476e-05 1.45805207328833 0.524590163934426 25.1 25 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.38744878357487e-05 9.05660375700476e-05 1.45805207328833 0.524590163934426 25.1 25 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.38744878357487e-05 9.05660375700476e-05 1.45805207328833 0.524590163934426 25.1 25 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.47009273641696e-14 3.29982006890978e-12 1.45805207328833 0.524590163934426 25.1 25 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0100935034050401 0.0279981585679767 1.45588235294118 0.523809523809524 25.1 25 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.36631354112506e-30 7.98377361503493e-28 1.45495028997514 0.523474178403756 25.1 25 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.05483510443436e-19 5.38501897100631e-17 1.45384615384615 0.523076923076923 25.1 25 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 6.59221914532657e-09 1.15811454861725e-07 1.45230524642289 0.522522522522523 25.1 25 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.00211688602059e-13 4.91728389243897e-12 1.45012787723785 0.521739130434783 25.1 25 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00758134819565112 0.0214905547458397 1.45012787723785 0.521739130434783 25.1 25 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 8.87910051412981e-11 2.3398074132605e-09 1.44926470588235 0.521428571428571 25.1 25 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000138127554092714 0.000687257026132632 1.44761029411765 0.520833333333333 25.1 25 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000138127554092714 0.000687257026132632 1.44761029411765 0.520833333333333 25.1 25 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.39731983315304e-09 2.72381660626955e-08 1.44619799139168 0.520325203252033 25.1 25 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.2045122543486e-06 1.85186457296086e-05 1.44529411764706 0.52 25.1 25 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.2045122543486e-06 1.85186457296086e-05 1.44529411764706 0.52 25.1 25 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.2045122543486e-06 1.85186457296086e-05 1.44529411764706 0.52 25.1 25 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.2045122543486e-06 1.85186457296086e-05 1.44529411764706 0.52 25.1 25 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.2045122543486e-06 1.85186457296086e-05 1.44529411764706 0.52 25.1 25 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00570805676858551 0.0169928133508309 1.44529411764706 0.52 25.1 25 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00570805676858551 0.0169928133508309 1.44529411764706 0.52 25.1 25 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00570805676858551 0.0169928133508309 1.44529411764706 0.52 25.1 25 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.89111843679512e-11 5.98013674568767e-10 1.44456269349845 0.519736842105263 25.1 25 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.12933621445836e-11 3.82629865041488e-10 1.44315610859729 0.519230769230769 25.1 25 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 8.72716125047556e-12 3.10468761485668e-10 1.44247952345495 0.518987341772152 25.1 25 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.30542315492154e-06 1.2384114329689e-05 1.44247952345495 0.518987341772152 25.1 25 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.30542315492154e-06 1.2384114329689e-05 1.44247952345495 0.518987341772152 25.1 25 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.5219411752107e-20 1.96883844756802e-18 1.44187914073479 0.51877133105802 25.1 25 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.19278095736416e-13 5.65775767443065e-12 1.44172695816294 0.518716577540107 25.1 25 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.58560417329525e-07 4.62788279333272e-06 1.43762677484787 0.517241379310345 25.1 25 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.58560417329525e-07 4.62788279333272e-06 1.43762677484787 0.517241379310345 25.1 25 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 3.64143692501171e-05 0.000221442937790242 1.43762677484787 0.517241379310345 25.1 25 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00325501335286096 0.0103390267882168 1.43762677484787 0.517241379310345 25.1 25 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00325501335286096 0.0103390267882168 1.43762677484787 0.517241379310345 25.1 25 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.36747312605293e-35 1.12297141945778e-32 1.43726235741445 0.517110266159696 25.1 25 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00246416426677141 0.00807950634012838 1.43453510436433 0.516129032258065 25.1 25 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00246416426677141 0.00807950634012838 1.43453510436433 0.516129032258065 25.1 25 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.61409568484207e-07 1.88267062256579e-06 1.43359133126935 0.515789473684211 25.1 25 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.61409568484207e-07 1.88267062256579e-06 1.43359133126935 0.515789473684211 25.1 25 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.15498424743136e-15 8.21771292047412e-14 1.43332893695595 0.515695067264574 25.1 25 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 1.64371203585115e-05 0.00010631828304619 1.43313419117647 0.515625 25.1 25 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00186810543273191 0.00639017795859977 1.43181818181818 0.515151515151515 25.1 25 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00141802169788282 0.00503203210994326 1.42941176470588 0.514285714285714 25.1 25 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00141802169788282 0.00503203210994326 1.42941176470588 0.514285714285714 25.1 25 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00107760300749051 0.00397261419600777 1.42726550079491 0.513513513513513 25.1 25 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000624180884119223 0.00257451999449755 1.42360114777618 0.51219512195122 25.1 25 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000624180884119223 0.00257451999449755 1.42360114777618 0.51219512195122 25.1 25 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000624180884119223 0.00257451999449755 1.42360114777618 0.51219512195122 25.1 25 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.51462906209462e-09 4.64716513683201e-08 1.42253358036128 0.511811023622047 25.1 25 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000475674035147354 0.00207441750120127 1.42202462380301 0.511627906976744 25.1 25 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.15452732139283e-09 2.38100344687245e-08 1.42105263157895 0.511278195488722 25.1 25 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.24655535376314e-13 1.3199566481157e-11 1.41865808823529 0.510416666666667 25.1 25 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 9.45267827631997e-05 0.000500043166810532 1.41497326203209 0.509090909090909 25.1 25 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 9.45267827631997e-05 0.000500043166810532 1.41497326203209 0.509090909090909 25.1 25 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 9.45267827631997e-05 0.000500043166810532 1.41497326203209 0.509090909090909 25.1 25 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 9.45267827631997e-05 0.000500043166810532 1.41497326203209 0.509090909090909 25.1 25 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 9.45267827631997e-05 0.000500043166810532 1.41497326203209 0.509090909090909 25.1 25 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 9.45267827631997e-05 0.000500043166810532 1.41497326203209 0.509090909090909 25.1 25 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.0894839318308e-11 3.78130642681764e-10 1.41437521754264 0.50887573964497 25.1 25 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.91656312748822e-06 2.9803579307036e-05 1.40729709605361 0.506329113924051 25.1 25 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 3.91656312748822e-06 2.9803579307036e-05 1.40729709605361 0.506329113924051 25.1 25 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.63413852710115e-11 5.28495255469304e-10 1.4060553633218 0.505882352941176 25.1 25 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 9.97070838308538e-08 1.23376678514178e-06 1.40269378779549 0.504672897196262 25.1 25 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.23842352643085e-08 1.8167800805269e-07 1.40100430416069 0.504065040650406 25.1 25 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.29482220127786e-09 4.29675262160316e-08 1.38970588235294 0.5 25.1 25 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000185129412262792 0.000893014080169334 1.38970588235294 0.5 25.1 25 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00123464399963614 0.00448188370276079 1.38970588235294 0.5 25.1 25 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00123464399963614 0.00448188370276079 1.38970588235294 0.5 25.1 25 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0115573423965981 0.0313259013911601 1.38970588235294 0.5 25.1 25 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0696831341133859 0.134795829607523 1.38970588235294 0.5 25.1 25 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0696831341133859 0.134795829607523 1.38970588235294 0.5 25.1 25 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0696831341133859 0.134795829607523 1.38970588235294 0.5 25.1 25 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0696831341133859 0.134795829607523 1.38970588235294 0.5 25.1 25 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0963052202946643 0.176600938761994 1.38970588235294 0.5 25.1 25 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 4.4851940973686e-06 3.34158701599765e-05 1.38970588235294 0.5 25.1 25 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 9.89975416788826e-06 6.64497650042688e-05 1.38970588235294 0.5 25.1 25 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.28964815024086e-05 8.57555755977921e-05 1.38970588235294 0.5 25.1 25 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.28964815024086e-05 8.57555755977921e-05 1.38970588235294 0.5 25.1 25 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.68052774414712e-05 0.000108207736648025 1.38970588235294 0.5 25.1 25 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000141550568975784 0.000699397429349099 1.38970588235294 0.5 25.1 25 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000544985134814784 0.00231496670698937 1.38970588235294 0.5 25.1 25 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00162465981642296 0.00569431260780758 1.38970588235294 0.5 25.1 25 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00214029245796385 0.00714938067531118 1.38970588235294 0.5 25.1 25 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00282311030213059 0.00910949197263453 1.38970588235294 0.5 25.1 25 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00372897931831579 0.0117396848892995 1.38970588235294 0.5 25.1 25 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00493326522638456 0.0149362476960537 1.38970588235294 0.5 25.1 25 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0086825600083852 0.0242260448861414 1.38970588235294 0.5 25.1 25 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0277628688748597 0.0656255189517033 1.38970588235294 0.5 25.1 25 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0277628688748597 0.0656255189517033 1.38970588235294 0.5 25.1 25 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0277628688748597 0.0656255189517033 1.38970588235294 0.5 25.1 25 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0374910024206385 0.084280721081467 1.38970588235294 0.5 25.1 25 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0374910024206385 0.084280721081467 1.38970588235294 0.5 25.1 25 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0374910024206385 0.084280721081467 1.38970588235294 0.5 25.1 25 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0374910024206385 0.084280721081467 1.38970588235294 0.5 25.1 25 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0374910024206385 0.084280721081467 1.38970588235294 0.5 25.1 25 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0374910024206385 0.084280721081467 1.38970588235294 0.5 25.1 25 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0509226394823741 0.10799242322417 1.38970588235294 0.5 25.1 25 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0509226394823741 0.10799242322417 1.38970588235294 0.5 25.1 25 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0509226394823741 0.10799242322417 1.38970588235294 0.5 25.1 25 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.45746736703378e-11 4.82320014718387e-10 1.3821118611379 0.497267759562842 25.1 25 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 8.59794894298043e-06 6.01280463984745e-05 1.37254901960784 0.493827160493827 25.1 25 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 8.59794894298043e-06 6.01280463984745e-05 1.37254901960784 0.493827160493827 25.1 25 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 9.34336418693727e-05 0.000500043166810532 1.36764705882353 0.492063492063492 25.1 25 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000159408514313147 0.000782201089198649 1.36615154536391 0.491525423728814 25.1 25 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.7770597319324e-11 2.3398074132605e-09 1.36615154536391 0.491525423728814 25.1 25 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.18812034136669e-07 3.44829100416036e-06 1.3644385026738 0.490909090909091 25.1 25 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 5.37930112296336e-10 1.15980992393589e-08 1.36412847347528 0.49079754601227 25.1 25 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000356565784394146 0.00159557582136123 1.36348501664817 0.490566037735849 25.1 25 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 6.98179073636249e-07 6.7585634134992e-06 1.36298076923077 0.490384615384615 25.1 25 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0013816839823609 0.00492765991704151 1.35738714090287 0.488372093023256 25.1 25 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00181603744298558 0.00628764302036126 1.3558106169297 0.48780487804878 25.1 25 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 6.00195244842438e-24 1.22011119058684e-21 1.35231469269322 0.486547085201794 25.1 25 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00314705088472808 0.0100409269259373 1.35214626391097 0.486486486486487 25.1 25 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00314705088472808 0.0100409269259373 1.35214626391097 0.486486486486487 25.1 25 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 6.10891005300665e-05 0.000349115622707971 1.35 0.485714285714286 25.1 25 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.21150992160873e-06 1.85186457296086e-05 1.3475935828877 0.484848484848485 25.1 25 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.00548039003415946 0.0164180947760187 1.3475935828877 0.484848484848485 25.1 25 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00548039003415946 0.0164180947760187 1.3475935828877 0.484848484848485 25.1 25 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00013553465378423 0.00067910497301042 1.34627757352941 0.484375 25.1 25 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.89277318491908e-45 2.69341624213985e-42 1.34568804897525 0.484162895927602 25.1 25 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 6.49296991774236e-14 3.29982006890978e-12 1.34558823529412 0.484126984126984 25.1 25 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 6.49296991774236e-14 3.29982006890978e-12 1.34558823529412 0.484126984126984 25.1 25 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 6.49296991774236e-14 3.29982006890978e-12 1.34558823529412 0.484126984126984 25.1 25 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 6.70382964395373e-20 7.94962465278846e-18 1.34511638880151 0.483957219251337 25.1 25 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0072480473760219 0.0207107859760626 1.34487666034156 0.483870967741935 25.1 25 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000301770105408298 0.00138522212901938 1.34178498985801 0.482758620689655 25.1 25 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.38493545837837e-05 9.05660375700476e-05 1.34065743944637 0.482352941176471 25.1 25 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.00718899546283e-12 1.54114322717395e-10 1.33917112299465 0.481818181818182 25.1 25 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000515756701373262 0.00220396932748994 1.33823529411765 0.481481481481481 25.1 25 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000515756701373262 0.00220396932748994 1.33823529411765 0.481481481481481 25.1 25 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0127460112768852 0.0339020075645002 1.33823529411765 0.481481481481481 25.1 25 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0127460112768852 0.0339020075645002 1.33823529411765 0.481481481481481 25.1 25 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0127460112768852 0.0339020075645002 1.33823529411765 0.481481481481481 25.1 25 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0127460112768852 0.0339020075645002 1.33823529411765 0.481481481481481 25.1 25 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000674807354055352 0.00273575744963181 1.3362556561086 0.480769230769231 25.1 25 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.16535168933599e-06 2.48856102426802e-05 1.33411764705882 0.48 25.1 25 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000883430357277628 0.00331694300370993 1.33411764705882 0.48 25.1 25 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.016956682976302 0.0433981292720822 1.33411764705882 0.48 25.1 25 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.72477425723509e-05 0.000380927756634412 1.3325946817083 0.479452054794521 25.1 25 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00115729163601412 0.00422263076422587 1.33180147058824 0.479166666666667 25.1 25 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 4.3304653106156e-07 4.46540009927971e-06 1.33131487889273 0.478991596638655 25.1 25 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 1.87805665868951e-13 8.09840795550053e-12 1.32975778546713 0.47843137254902 25.1 25 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0226165048500072 0.0548267230009545 1.32928388746803 0.478260869565217 25.1 25 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.000148701044679769 0.000732185420689657 1.32748024582968 0.477611940298507 25.1 25 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00199026835352845 0.00674321873112139 1.32653743315508 0.477272727272727 25.1 25 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.56434246944895e-05 0.000160751512512152 1.32352941176471 0.476190476190476 25.1 25 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.56434246944895e-05 0.000160751512512152 1.32352941176471 0.476190476190476 25.1 25 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0302563516392466 0.0710475055819273 1.32352941176471 0.476190476190476 25.1 25 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0302563516392466 0.0710475055819273 1.32352941176471 0.476190476190476 25.1 25 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 7.32746956671661e-05 0.000404603079267601 1.31656346749226 0.473684210526316 25.1 25 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0406213621527572 0.0907444244009002 1.31656346749226 0.473684210526316 25.1 25 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0406213621527572 0.0907444244009002 1.31656346749226 0.473684210526316 25.1 25 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0406213621527572 0.0907444244009002 1.31656346749226 0.473684210526316 25.1 25 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0406213621527572 0.0907444244009002 1.31656346749226 0.473684210526316 25.1 25 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 2.23837460681145e-06 1.85186457296086e-05 1.31390374331551 0.472727272727273 25.1 25 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.000124014045113637 0.000625787185094701 1.3125 0.472222222222222 25.1 25 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000124014045113637 0.000625787185094701 1.3125 0.472222222222222 25.1 25 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00594842166503896 0.0175979293749489 1.3125 0.472222222222222 25.1 25 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 9.63023287836967e-11 2.4916038883491e-09 1.31029411764706 0.471428571428571 25.1 25 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.000210081953790567 0.000989080600860707 1.30795847750865 0.470588235294118 25.1 25 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00784241646262953 0.0221863988594867 1.30795847750865 0.470588235294118 25.1 25 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.054771248860512 0.114785695329173 1.30795847750865 0.470588235294118 25.1 25 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.054771248860512 0.114785695329173 1.30795847750865 0.470588235294118 25.1 25 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.054771248860512 0.114785695329173 1.30795847750865 0.470588235294118 25.1 25 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.054771248860512 0.114785695329173 1.30795847750865 0.470588235294118 25.1 25 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.054771248860512 0.114785695329173 1.30795847750865 0.470588235294118 25.1 25 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.054771248860512 0.114785695329173 1.30795847750865 0.470588235294118 25.1 25 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.054771248860512 0.114785695329173 1.30795847750865 0.470588235294118 25.1 25 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.28153341447671e-07 1.55865132376099e-06 1.30224187577129 0.468531468531469 25.1 25 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 7.91202085328744e-05 0.000433030987470309 1.30174981384959 0.468354430379747 25.1 25 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00214646081069282 0.00715319375554072 1.30100125156446 0.468085106382979 25.1 25 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 5.25117373002515e-06 3.85176299887927e-05 1.29879054425509 0.467289719626168 25.1 25 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.000604790670739125 0.00252380388405213 1.29705882352941 0.466666666666667 25.1 25 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0742387402296826 0.141610894566807 1.29705882352941 0.466666666666667 25.1 25 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 3.88534283255049e-05 0.000233284508469171 1.29495320855615 0.465909090909091 25.1 25 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 5.34099972663751e-34 1.90006065275129e-31 1.29183927091964 0.464788732394366 25.1 25 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.000225484154732797 0.00104176607852198 1.29183927091964 0.464788732394366 25.1 25 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 9.97394974445907e-07 9.58981789619274e-06 1.29122278832793 0.464566929133858 25.1 25 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 6.86126727087953e-08 8.8759848422378e-07 1.29108159392789 0.464516129032258 25.1 25 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0181262092021234 0.0460599923118242 1.29044117647059 0.464285714285714 25.1 25 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0181262092021234 0.0460599923118242 1.29044117647059 0.464285714285714 25.1 25 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 3.20419847547324e-05 0.000199108053737923 1.28510436432638 0.462365591397849 25.1 25 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00634109925465661 0.0183030106275383 1.28280542986425 0.461538461538462 25.1 25 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0240487883773735 0.0581008928030603 1.28280542986425 0.461538461538462 25.1 25 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.101290467247383 0.182682300244647 1.28280542986425 0.461538461538462 25.1 25 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 8.96404720354826e-23 1.41731546340546e-20 1.28040317250496 0.460674157303371 25.1 25 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.03589572779692e-05 0.000130499082011487 1.27852941176471 0.46 25.1 25 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00832958682830322 0.0233119871146303 1.27702702702703 0.459459459459459 25.1 25 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.29658725796689e-07 1.56359632888719e-06 1.27463469464219 0.45859872611465 25.1 25 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00298345011234405 0.00956182322041798 1.27389705882353 0.458333333333333 25.1 25 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0319742576951996 0.0747116070611971 1.27389705882353 0.458333333333333 25.1 25 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0319742576951996 0.0747116070611971 1.27389705882353 0.458333333333333 25.1 25 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0319742576951996 0.0747116070611971 1.27389705882353 0.458333333333333 25.1 25 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000116690407782474 0.000606023541147666 1.27250177179305 0.457831325301205 25.1 25 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0038980600619681 0.0122179283440101 1.26886189258312 0.456521739130435 25.1 25 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0038980600619681 0.0122179283440101 1.26886189258312 0.456521739130435 25.1 25 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00509542355609033 0.0153293609309018 1.26336898395722 0.454545454545455 25.1 25 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00509542355609033 0.0153293609309018 1.26336898395722 0.454545454545455 25.1 25 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0144137052542554 0.0377729329222935 1.26336898395722 0.454545454545455 25.1 25 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0144137052542554 0.0377729329222935 1.26336898395722 0.454545454545455 25.1 25 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0426151632099141 0.0946043326797312 1.26336898395722 0.454545454545455 25.1 25 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0426151632099141 0.0946043326797312 1.26336898395722 0.454545454545455 25.1 25 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0426151632099141 0.0946043326797312 1.26336898395722 0.454545454545455 25.1 25 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.139380633172213 0.232246652229577 1.26336898395722 0.454545454545455 25.1 25 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.000123069115065428 0.000625454824064658 1.26043091655267 0.453488372093023 25.1 25 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000883045327037889 0.00331694300370993 1.25942095588235 0.453125 25.1 25 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00240454023484633 0.00792051100506093 1.25860155382908 0.452830188679245 25.1 25 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00666385762552619 0.0191569078810581 1.25735294117647 0.452380952380952 25.1 25 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00114617829112477 0.00419283215493714 1.25521821631879 0.451612903225806 25.1 25 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00114617829112477 0.00419283215493714 1.25521821631879 0.451612903225806 25.1 25 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0569574804563593 0.1184948752769 1.25073529411765 0.45 25.1 25 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0569574804563593 0.1184948752769 1.25073529411765 0.45 25.1 25 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0569574804563593 0.1184948752769 1.25073529411765 0.45 25.1 25 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.38362306167569e-05 0.000151576561315505 1.24946033459255 0.44954128440367 25.1 25 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.000712837804160115 0.00282224113506786 1.24872122762148 0.449275362318841 25.1 25 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 5.63731670089925e-19 5.34793444358643e-17 1.2484756097561 0.449186991869919 25.1 25 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000343689149381917 0.00154315767833072 1.24717194570136 0.448717948717949 25.1 25 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0250518886634886 0.0603195221119194 1.24594320486815 0.448275862068966 25.1 25 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0114158024328608 0.0310013108052688 1.24342105263158 0.447368421052632 25.1 25 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 4.6623405284074e-06 3.43757024452007e-05 1.2423128342246 0.446969696969697 25.1 25 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000277283342262973 0.0012769391457612 1.23901488306166 0.44578313253012 25.1 25 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.20118486492923e-05 0.000199108053737923 1.23810160427807 0.445454545454545 25.1 25 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 4.53249046690129e-07 4.62788279333272e-06 1.23717718794835 0.445121951219512 25.1 25 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000741755575906801 0.00282224113506786 1.23529411764706 0.444444444444444 25.1 25 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0330910100577642 0.0769420054120891 1.23529411764706 0.444444444444444 25.1 25 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0330910100577642 0.0769420054120891 1.23529411764706 0.444444444444444 25.1 25 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000357717858060933 0.00159571320382667 1.23529411764706 0.444444444444444 25.1 25 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00422651399934279 0.0129899123565114 1.22935520361991 0.442307692307692 25.1 25 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00422651399934279 0.0129899123565114 1.22935520361991 0.442307692307692 25.1 25 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.35201616660433e-12 1.32497750141054e-10 1.22771562612775 0.441717791411043 25.1 25 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0196015648265916 0.0480086518902578 1.22621107266436 0.441176470588235 25.1 25 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0196015648265916 0.0480086518902578 1.22621107266436 0.441176470588235 25.1 25 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0196015648265916 0.0480086518902578 1.22621107266436 0.441176470588235 25.1 25 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0437737806886191 0.0964844277349623 1.22294117647059 0.44 25.1 25 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0437737806886191 0.0964844277349623 1.22294117647059 0.44 25.1 25 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0437737806886191 0.0964844277349623 1.22294117647059 0.44 25.1 25 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000476693269777101 0.00207441750120127 1.22022955523673 0.439024390243902 25.1 25 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0117625563849231 0.0316410543208802 1.22022955523673 0.439024390243902 25.1 25 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0117625563849231 0.0316410543208802 1.22022955523673 0.439024390243902 25.1 25 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0117625563849231 0.0316410543208802 1.22022955523673 0.439024390243902 25.1 25 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0117625563849231 0.0316410543208802 1.22022955523673 0.439024390243902 25.1 25 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.99831025062544e-08 5.41866236822857e-07 1.21764705882353 0.438095238095238 25.1 25 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 9.02429174145334e-05 0.000490566022902839 1.21764705882353 0.438095238095238 25.1 25 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00712454022974619 0.0203988345008628 1.21599264705882 0.4375 25.1 25 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.102820314081161 0.184041895518858 1.21599264705882 0.4375 25.1 25 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.102820314081161 0.184041895518858 1.21599264705882 0.4375 25.1 25 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.102820314081161 0.184041895518858 1.21599264705882 0.4375 25.1 25 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.102820314081161 0.184041895518858 1.21599264705882 0.4375 25.1 25 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.102820314081161 0.184041895518858 1.21599264705882 0.4375 25.1 25 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 4.01828725581839e-10 8.9344105703587e-09 1.21411127627946 0.436823104693141 25.1 25 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00434571304100008 0.0133274777097912 1.21283422459893 0.436363636363636 25.1 25 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.015337163979655 0.0399721324964268 1.21153846153846 0.435897435897436 25.1 25 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000490109949588647 0.00210702857481766 1.2098615916955 0.435294117647059 25.1 25 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000490109949588647 0.00210702857481766 1.2098615916955 0.435294117647059 25.1 25 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00924966907409912 0.0257075763524278 1.20843989769821 0.434782608695652 25.1 25 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0579987465636884 0.120134230509649 1.20843989769821 0.434782608695652 25.1 25 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0337421521408227 0.0782004600918414 1.20441176470588 0.433333333333333 25.1 25 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.77792885040149e-18 1.48823103183607e-16 1.20230246214072 0.432574430823117 25.1 25 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 4.56281566552492e-06 3.38171181877185e-05 1.20142314990512 0.432258064516129 25.1 25 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000808057289747577 0.00306630806216214 1.20098039215686 0.432098765432099 25.1 25 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00727504321935949 0.0207462655333638 1.19896193771626 0.431372549019608 25.1 25 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000121619813780517 0.000621864607801458 1.19846195358877 0.431192660550459 25.1 25 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.06624727680731e-30 3.03453974979361e-28 1.19634340222576 0.43043043043043 25.1 25 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00215452841747367 0.0071633035936099 1.19117647058824 0.428571428571429 25.1 25 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0155865804544709 0.0404001894111331 1.19117647058824 0.428571428571429 25.1 25 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0260889610252906 0.0620812567541615 1.19117647058824 0.428571428571429 25.1 25 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0443146106994948 0.0964844277349623 1.19117647058824 0.428571428571429 25.1 25 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0769833270691941 0.145801182526241 1.19117647058824 0.428571428571429 25.1 25 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.13906633807114 0.232246652229577 1.19117647058824 0.428571428571429 25.1 25 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.13906633807114 0.232246652229577 1.19117647058824 0.428571428571429 25.1 25 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.13906633807114 0.232246652229577 1.19117647058824 0.428571428571429 25.1 25 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.13906633807114 0.232246652229577 1.19117647058824 0.428571428571429 25.1 25 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.13906633807114 0.232246652229577 1.19117647058824 0.428571428571429 25.1 25 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.13906633807114 0.232246652229577 1.19117647058824 0.428571428571429 25.1 25 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.13906633807114 0.232246652229577 1.19117647058824 0.428571428571429 25.1 25 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.13906633807114 0.232246652229577 1.19117647058824 0.428571428571429 25.1 25 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.8851855385313e-05 0.000233284508469171 1.18814548720251 0.427480916030534 25.1 25 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.8851855385313e-05 0.000233284508469171 1.18814548720251 0.427480916030534 25.1 25 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00450678004112452 0.0137917161258499 1.18466730954677 0.426229508196721 25.1 25 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0073802645810871 0.0210042329977739 1.18382352941176 0.425925925925926 25.1 25 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0202284015526482 0.0492894099476342 1.18125 0.425 25.1 25 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00579438615889897 0.0171779406335692 1.17771684945165 0.423728813559322 25.1 25 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.000846588473634067 0.00319547850923416 1.17352941176471 0.422222222222222 25.1 25 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.015723731129054 0.0406815807211707 1.17352941176471 0.422222222222222 25.1 25 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0262460766934262 0.062350863330126 1.1702786377709 0.421052631578947 25.1 25 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.102382746082689 0.184041895518858 1.1702786377709 0.421052631578947 25.1 25 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.63370843280357e-42 1.16238354993974e-39 1.16990088482133 0.420916720464816 25.1 25 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.0122493313614464 0.0328263625750249 1.16735294117647 0.42 25.1 25 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0443958056268582 0.0964844277349623 1.16555977229602 0.419354838709677 25.1 25 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0203124159874325 0.0493252012800621 1.16347469220246 0.418604651162791 25.1 25 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.189164561071375 0.300425413397954 1.15808823529412 0.416666666666667 25.1 25 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.189164561071375 0.300425413397954 1.15808823529412 0.416666666666667 25.1 25 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.189164561071375 0.300425413397954 1.15808823529412 0.416666666666667 25.1 25 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.189164561071375 0.300425413397954 1.15808823529412 0.416666666666667 25.1 25 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.189164561071375 0.300425413397954 1.15808823529412 0.416666666666667 25.1 25 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.189164561071375 0.300425413397954 1.15808823529412 0.416666666666667 25.1 25 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0340422699869579 0.0785727488667466 1.15808823529412 0.416666666666667 25.1 25 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0579118262543226 0.12012905067041 1.1501014198783 0.413793103448276 25.1 25 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0579118262543226 0.12012905067041 1.1501014198783 0.413793103448276 25.1 25 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0202795525751332 0.0493252012800621 1.1480179028133 0.41304347826087 25.1 25 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0441337961559722 0.0964844277349623 1.14446366782007 0.411764705882353 25.1 25 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.136454659735616 0.232246652229577 1.14446366782007 0.411764705882353 25.1 25 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.136454659735616 0.232246652229577 1.14446366782007 0.411764705882353 25.1 25 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.100776671279465 0.182682300244647 1.1370320855615 0.409090909090909 25.1 25 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.41888989346422e-15 9.6146681828552e-14 1.13251303631873 0.40746500777605 25.1 25 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0755278634824984 0.143301532980794 1.13235294117647 0.407407407407407 25.1 25 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0755278634824984 0.143301532980794 1.13235294117647 0.407407407407407 25.1 25 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0755278634824984 0.143301532980794 1.13235294117647 0.407407407407407 25.1 25 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0755278634824984 0.143301532980794 1.13235294117647 0.407407407407407 25.1 25 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0334591956490018 0.0776711833744365 1.125 0.404761904761905 25.1 25 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.00106624412737147 0.00394094907337559 1.11672794117647 0.401785714285714 25.1 25 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0196767321161724 0.0480274267604001 1.11176470588235 0.4 25.1 25 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0196767321161724 0.0480274267604001 1.11176470588235 0.4 25.1 25 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0561636862430932 0.117358187259797 1.11176470588235 0.4 25.1 25 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.132666256500243 0.22966433454969 1.11176470588235 0.4 25.1 25 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.132666256500243 0.22966433454969 1.11176470588235 0.4 25.1 25 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0740249423299894 0.141423297645098 1.11176470588235 0.4 25.1 25 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0984635915143168 0.180326500289412 1.11176470588235 0.4 25.1 25 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.182284736632112 0.291778605430254 1.11176470588235 0.4 25.1 25 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.182284736632112 0.291778605430254 1.11176470588235 0.4 25.1 25 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.182284736632112 0.291778605430254 1.11176470588235 0.4 25.1 25 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000121925668008859 0.000621864607801458 1.09883720930233 0.395348837209302 25.1 25 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 9.38371146740637e-06 6.32844616972477e-05 1.09745013885382 0.394849785407725 25.1 25 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0722282251355784 0.138332118933954 1.09491978609626 0.393939393939394 25.1 25 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0722282251355784 0.138332118933954 1.09491978609626 0.393939393939394 25.1 25 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0957246741067948 0.176600938761994 1.09191176470588 0.392857142857143 25.1 25 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.0957246741067948 0.176600938761994 1.09191176470588 0.392857142857143 25.1 25 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.128276765739607 0.222878922646472 1.08759590792839 0.391304347826087 25.1 25 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0702409511333608 0.135071450625368 1.08088235294118 0.388888888888889 25.1 25 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.174685291390714 0.280878157795464 1.08088235294118 0.388888888888889 25.1 25 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.174685291390714 0.280878157795464 1.08088235294118 0.388888888888889 25.1 25 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.174685291390714 0.280878157795464 1.08088235294118 0.388888888888889 25.1 25 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0927380813003877 0.172957129345284 1.07590132827324 0.387096774193548 25.1 25 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.000162840787004944 0.000796297044357511 1.07123161764706 0.385416666666667 25.1 25 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.12360410180439 0.215549800082901 1.06900452488688 0.384615384615385 25.1 25 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.24408586971137 0.372276733761285 1.06900452488688 0.384615384615385 25.1 25 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.24408586971137 0.372276733761285 1.06900452488688 0.384615384615385 25.1 25 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.24408586971137 0.372276733761285 1.06900452488688 0.384615384615385 25.1 25 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.118832525572194 0.208620283245665 1.05425963488844 0.379310344827586 25.1 25 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0154799512039304 0.0401970265751696 1.04636678200692 0.376470588235294 25.1 25 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0154799512039304 0.0401970265751696 1.04636678200692 0.376470588235294 25.1 25 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.114072125325976 0.202652477326921 1.04227941176471 0.375 25.1 25 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.159290224872948 0.263876589050297 1.04227941176471 0.375 25.1 25 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.159290224872948 0.263876589050297 1.04227941176471 0.375 25.1 25 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.229963390162683 0.352627051941269 1.04227941176471 0.375 25.1 25 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.229963390162683 0.352627051941269 1.04227941176471 0.375 25.1 25 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.229963390162683 0.352627051941269 1.04227941176471 0.375 25.1 25 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.229963390162683 0.352627051941269 1.04227941176471 0.375 25.1 25 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.229963390162683 0.352627051941269 1.04227941176471 0.375 25.1 25 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000689014973896813 0.00278542132913399 1.02993430874888 0.370558375634518 25.1 25 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.151884241993738 0.252489808828376 1.02941176470588 0.37037037037037 25.1 25 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.151884241993738 0.252489808828376 1.02941176470588 0.37037037037037 25.1 25 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0132384213305463 0.0350805838982634 1.02838235294118 0.37 25.1 25 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0770502384116188 0.145801182526241 1.02717391304348 0.369565217391304 25.1 25 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0413294528695419 0.0921815226228183 1.0262443438914 0.369230769230769 25.1 25 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.104825578963296 0.186854502961697 1.02399380804954 0.368421052631579 25.1 25 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.216861776153728 0.334700984237261 1.02399380804954 0.368421052631579 25.1 25 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.216861776153728 0.334700984237261 1.02399380804954 0.368421052631579 25.1 25 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0740410096595912 0.141423297645098 1.02100840336134 0.36734693877551 25.1 25 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.100403833967438 0.182682300244647 1.01685796269727 0.365853658536585 25.1 25 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0711161145409727 0.136569812404594 1.01555429864253 0.365384615384615 25.1 25 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.049115138358335 0.104783870890421 1.01069518716578 0.363636363636364 25.1 25 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.137982925434774 0.232246652229577 1.01069518716578 0.363636363636364 25.1 25 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00698923609907992 0.0200517801794168 1.00531914893617 0.361702127659574 25.1 25 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.012234751166681 0.0328263625750249 1.00241080038573 0.360655737704918 25.1 25 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.062900619852487 0.125360759173794 1.00241080038573 0.360655737704918 25.1 25 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0283256347851701 0.0668447401315042 0.994736842105263 0.357894736842105 25.1 25 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.85195711351921e-06 2.26722624164125e-05 0.993850267379679 0.357575757575758 25.1 25 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0555509693046864 0.116248572530248 0.992647058823529 0.357142857142857 25.1 25 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.183084001930929 0.292728690727766 0.992647058823529 0.357142857142857 25.1 25 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.302430053955942 0.424416140807993 0.992647058823529 0.357142857142857 25.1 25 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.302430053955942 0.424416140807993 0.992647058823529 0.357142857142857 25.1 25 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.302430053955942 0.424416140807993 0.992647058823529 0.357142857142857 25.1 25 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.302430053955942 0.424416140807993 0.992647058823529 0.357142857142857 25.1 25 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.302430053955942 0.424416140807993 0.992647058823529 0.357142857142857 25.1 25 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.113998805519657 0.202652477326921 0.988235294117647 0.355555555555556 25.1 25 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.17339338014693 0.279749183615739 0.986242884250474 0.354838709677419 25.1 25 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.17339338014693 0.279749183615739 0.986242884250474 0.354838709677419 25.1 25 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00757347585386954 0.0214905547458397 0.984015345268542 0.354037267080745 25.1 25 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00111731596603206 0.00410837369422125 0.980968858131488 0.352941176470588 25.1 25 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.16436269503343 0.271962924456478 0.980968858131488 0.352941176470588 25.1 25 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.28096815221381 0.405343828776977 0.980968858131488 0.352941176470588 25.1 25 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.28096815221381 0.405343828776977 0.980968858131488 0.352941176470588 25.1 25 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.28096815221381 0.405343828776977 0.980968858131488 0.352941176470588 25.1 25 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.28096815221381 0.405343828776977 0.980968858131488 0.352941176470588 25.1 25 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.28096815221381 0.405343828776977 0.980968858131488 0.352941176470588 25.1 25 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0087253686922079 0.024297846671256 0.977941176470588 0.351851851851852 25.1 25 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.262197825197912 0.388158369770147 0.972794117647059 0.35 25.1 25 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.262197825197912 0.388158369770147 0.972794117647059 0.35 25.1 25 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.262197825197912 0.388158369770147 0.972794117647059 0.35 25.1 25 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.262197825197912 0.388158369770147 0.972794117647059 0.35 25.1 25 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0129115854700959 0.0342783323207957 0.96831119544592 0.348387096774194 25.1 25 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.127179702981287 0.221513729917224 0.964285714285714 0.346938775510204 25.1 25 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.230511673136889 0.352707646100853 0.96210407239819 0.346153846153846 25.1 25 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.230511673136889 0.352707646100853 0.96210407239819 0.346153846153846 25.1 25 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0141836573339716 0.0373074757601509 0.961431742508324 0.345911949685535 25.1 25 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0141836573339716 0.0373074757601509 0.961431742508324 0.345911949685535 25.1 25 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.104630035648785 0.186811217977693 0.956846673095468 0.344262295081967 25.1 25 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.204466418386478 0.317290854268221 0.955422794117647 0.34375 25.1 25 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.204466418386478 0.317290854268221 0.955422794117647 0.34375 25.1 25 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.0504838080102832 0.107542602991966 0.954545454545454 0.343434343434343 25.1 25 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.155212106595653 0.257720919119737 0.946182728410513 0.340425531914894 25.1 25 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0234513614535638 0.0567538900483356 0.937838325514255 0.337423312883436 25.1 25 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00642863737854772 0.0185181194122943 0.937632884479093 0.337349397590361 25.1 25 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.059829073773401 0.121797957052288 0.935129191863662 0.336448598130841 25.1 25 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.178446244999457 0.286601587623282 0.926470588235294 0.333333333333333 25.1 25 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.211069983592504 0.326470202882754 0.926470588235294 0.333333333333333 25.1 25 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.211069983592504 0.326470202882754 0.926470588235294 0.333333333333333 25.1 25 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.211069983592504 0.326470202882754 0.926470588235294 0.333333333333333 25.1 25 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.269825388708465 0.395428968210243 0.926470588235294 0.333333333333333 25.1 25 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.288626516672391 0.407455886135726 0.926470588235294 0.333333333333333 25.1 25 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.288626516672391 0.407455886135726 0.926470588235294 0.333333333333333 25.1 25 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.30983040049104 0.434373063939655 0.926470588235294 0.333333333333333 25.1 25 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.334109582625358 0.460508490972395 0.926470588235294 0.333333333333333 25.1 25 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.334109582625358 0.460508490972395 0.926470588235294 0.333333333333333 25.1 25 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.334109582625358 0.460508490972395 0.926470588235294 0.333333333333333 25.1 25 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.252963973665501 0.384992229439581 0.926470588235294 0.333333333333333 25.1 25 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.252963973665501 0.384992229439581 0.926470588235294 0.333333333333333 25.1 25 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.362502712617857 0.491745815114595 0.926470588235294 0.333333333333333 25.1 25 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.362502712617857 0.491745815114595 0.926470588235294 0.333333333333333 25.1 25 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.362502712617857 0.491745815114595 0.926470588235294 0.333333333333333 25.1 25 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.362502712617857 0.491745815114595 0.926470588235294 0.333333333333333 25.1 25 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.362502712617857 0.491745815114595 0.926470588235294 0.333333333333333 25.1 25 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0287445567995938 0.0677210336520231 0.916454689984102 0.32972972972973 25.1 25 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.127507385688456 0.221812970458035 0.914280185758514 0.328947368421053 25.1 25 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0545237376977389 0.114785695329173 0.913235294117647 0.328571428571429 25.1 25 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.172889279748075 0.279701030345888 0.910496957403651 0.327586206896552 25.1 25 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.172889279748075 0.279701030345888 0.910496957403651 0.327586206896552 25.1 25 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.172889279748075 0.279701030345888 0.910496957403651 0.327586206896552 25.1 25 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.256389282882038 0.388158369770147 0.901430842607313 0.324324324324324 25.1 25 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.290854732483868 0.410194533522839 0.896584440227704 0.32258064516129 25.1 25 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.31091341402414 0.435462389917669 0.893382352941176 0.321428571428571 25.1 25 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0816081780762958 0.154016495228871 0.892657793044225 0.321167883211679 25.1 25 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0816081780762958 0.154016495228871 0.892657793044225 0.321167883211679 25.1 25 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.333389486336021 0.460508490972395 0.889411764705882 0.32 25.1 25 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.333389486336021 0.460508490972395 0.889411764705882 0.32 25.1 25 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.333389486336021 0.460508490972395 0.889411764705882 0.32 25.1 25 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.358874405012833 0.489624427932178 0.884358288770054 0.318181818181818 25.1 25 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.358874405012833 0.489624427932178 0.884358288770054 0.318181818181818 25.1 25 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.358874405012833 0.489624427932178 0.884358288770054 0.318181818181818 25.1 25 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.103632674088632 0.185262933703672 0.878784602076125 0.316176470588235 25.1 25 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.11840832335165 0.208620283245665 0.875405280222325 0.31496062992126 25.1 25 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.104916899414192 0.186854502961697 0.864329268292683 0.310975609756098 25.1 25 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.12993379215756 0.225482666146595 0.86122618061309 0.309859154929577 25.1 25 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.217234864859144 0.334913556548821 0.857843137254902 0.308641975308642 25.1 25 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.379112958868967 0.511838463444535 0.855203619909502 0.307692307692308 25.1 25 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.370302140643705 0.500417802598283 0.842245989304813 0.303030303030303 25.1 25 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.370302140643705 0.500417802598283 0.842245989304813 0.303030303030303 25.1 25 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.370302140643705 0.500417802598283 0.842245989304813 0.303030303030303 25.1 25 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.370302140643705 0.500417802598283 0.842245989304813 0.303030303030303 25.1 25 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 7.78434263884962e-05 0.000427688014481969 0.836535150645624 0.300975609756098 25.1 25 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.442235153262371 0.572612031931168 0.833823529411765 0.3 25.1 25 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.334297449876658 0.460508490972395 0.833823529411765 0.3 25.1 25 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.396185717770523 0.519043201056451 0.833823529411765 0.3 25.1 25 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.481822737094465 0.606219058254133 0.817474048442907 0.294117647058824 25.1 25 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.481822737094465 0.606219058254133 0.817474048442907 0.294117647058824 25.1 25 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.387664137165183 0.519043201056451 0.810661764705882 0.291666666666667 25.1 25 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.387664137165183 0.519043201056451 0.810661764705882 0.291666666666667 25.1 25 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.360092757450303 0.490816086064925 0.805626598465473 0.289855072463768 25.1 25 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.345817389069397 0.475916967742506 0.79834167709637 0.287234042553192 25.1 25 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.495197054370903 0.618040910795451 0.794117647058824 0.285714285714286 25.1 25 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.495197054370903 0.618040910795451 0.794117647058824 0.285714285714286 25.1 25 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.431591149642013 0.562102964066483 0.786625971143174 0.283018867924528 25.1 25 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.506204738359029 0.624743575615697 0.778235294117647 0.28 25.1 25 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.431748798119934 0.562102964066483 0.774013402829486 0.278481012658228 25.1 25 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.538635488813353 0.653991724045564 0.772058823529412 0.277777777777778 25.1 25 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.523870077075007 0.640986345380683 0.758021390374332 0.272727272727273 25.1 25 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.49458809973035 0.618040910795451 0.748303167420814 0.269230769230769 25.1 25 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.559041506725966 0.677034948145574 0.741176470588235 0.266666666666667 25.1 25 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.532996402946138 0.647697592990909 0.738830975428146 0.265822784810127 25.1 25 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.549837432395489 0.666455422741721 0.737394957983193 0.26530612244898 25.1 25 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.542266347819822 0.657838885718335 0.732210626185958 0.263440860215054 25.1 25 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.592353893802753 0.704811863124176 0.731424148606811 0.263157894736842 25.1 25 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.600699190353473 0.704811863124176 0.717267552182163 0.258064516129032 25.1 25 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.64239347398288 0.750513886270638 0.694852941176471 0.25 25.1 25 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.669876339962991 0.776881851481121 0.694852941176471 0.25 25.1 25 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.640118708482806 0.748470765958121 0.694852941176471 0.25 25.1 25 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.675375981145436 0.782622167076511 0.681742508324084 0.245283018867925 25.1 25 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.679734066892565 0.78703138908716 0.670892494929006 0.241379310344828 25.1 25 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.764510775952587 0.864784446884365 0.659035779260158 0.237113402061856 25.1 25 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.712283712129766 0.81151298827915 0.653979238754325 0.235294117647059 25.1 25 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.810683044723 0.905496053878202 0.626346313173156 0.225352112676056 25.1 25 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.767736805998417 0.867743824412825 0.604219948849105 0.217391304347826 25.1 25 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.956394470450415 1 0.601992409867173 0.216589861751152 25.1 25 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.991302733997421 1 0.594564887810794 0.213917525773196 25.1 25 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.825588475561895 0.920699373608602 0.585139318885449 0.210526315789474 25.1 25 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.853533570759962 0.942995552167256 0.579044117647059 0.208333333333333 25.1 25 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.992853245781868 1 0.565808823529412 0.203571428571429 25.1 25 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.856297425102706 0.944808081048739 0.555882352941176 0.2 25.1 25 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.830673931496925 0.924953223674082 0.555882352941176 0.2 25.1 25 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.866569660130897 0.954153118582381 0.537950664136622 0.193548387096774 25.1 25 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.856502055202301 0.944808081048739 0.534502262443439 0.192307692307692 25.1 25 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.91455348787081 0.998013507086014 0.517099863201094 0.186046511627907 25.1 25 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.996252096274482 1 0.505347593582888 0.181818181818182 25.1 25 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.931281896150135 1 0.476470588235294 0.171428571428571 25.1 25 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.989943324773993 1 0.463235294117647 0.166666666666667 25.1 25 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.94115567554011 1 0.448292220113852 0.161290322580645 25.1 25 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.94115567554011 1 0.448292220113852 0.161290322580645 25.1 25 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.43173062675952 0.155331654072208 25.1 25 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.361876396128071 0.130198915009042 25.1 25 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 2.60968080722829e-05 0.000195616938629447 4.32169117647059 0.875 25.2 25 2 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.000697133764799994 0.00330673782436797 4.11589635854342 0.833333333333333 25.2 25 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 4.23470137656652e-11 1.09563273797348e-09 4.04106187929717 0.818181818181818 25.2 25 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 3.16640614534518e-06 3.21842567487585e-05 3.79928894634777 0.769230769230769 25.2 25 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 1.45643906545224e-05 0.000115782837437907 3.70430672268908 0.75 25.2 25 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00209944226597685 0.00853573241281446 3.52791116446579 0.714285714285714 25.2 25 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 5.13446620817877e-07 6.89277869267772e-06 3.29271708683473 0.666666666666667 25.2 25 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000167034414150181 0.00103794747308169 3.29271708683473 0.666666666666667 25.2 25 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.05091527617734e-06 2.19432514135364e-05 3.21039915966387 0.65 25.2 25 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 1.19186265776433e-06 1.46208669137814e-05 3.14304812834225 0.636363636363636 25.2 25 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.000669619798055003 0.00318685275127849 3.14304812834225 0.636363636363636 25.2 25 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000669619798055003 0.00318685275127849 3.14304812834225 0.636363636363636 25.2 25 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000669619798055003 0.00318685275127849 3.14304812834225 0.636363636363636 25.2 25 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00482092765410467 0.0173236869994721 3.08692226890756 0.625 25.2 25 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00482092765410467 0.0173236869994721 3.08692226890756 0.625 25.2 25 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00482092765410467 0.0173236869994721 3.08692226890756 0.625 25.2 25 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00482092765410467 0.0173236869994721 3.08692226890756 0.625 25.2 25 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 4.54930184113644e-06 4.23114805224651e-05 3.05752300920368 0.619047619047619 25.2 25 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 3.91872712598056e-07 5.41393077696149e-06 3.03943115707822 0.615384615384615 25.2 25 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.000369953707510197 0.00198817398851416 3.03943115707822 0.615384615384615 25.2 25 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 3.03224393103837e-05 0.000220845188531351 3.01832399626517 0.611111111111111 25.2 25 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 1.25945064510762e-07 1.96944864614082e-06 2.96344537815126 0.6 25.2 25 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.000203326278470882 0.00113910745773254 2.96344537815126 0.6 25.2 25 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000203326278470882 0.00113910745773254 2.96344537815126 0.6 25.2 25 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00257047769676689 0.0101128436937443 2.96344537815126 0.6 25.2 25 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00257047769676689 0.0101128436937443 2.96344537815126 0.6 25.2 25 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00257047769676689 0.0101128436937443 2.96344537815126 0.6 25.2 25 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.23938047056012e-08 4.4258866800098e-07 2.88112745098039 0.583333333333333 25.2 25 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 5.21129732807807e-06 4.72336057188223e-05 2.88112745098039 0.583333333333333 25.2 25 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00137323933552176 0.00574741051308078 2.88112745098039 0.583333333333333 25.2 25 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00137323933552176 0.00574741051308078 2.88112745098039 0.583333333333333 25.2 25 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00137323933552176 0.00574741051308078 2.88112745098039 0.583333333333333 25.2 25 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000735659420511276 0.00345492856563546 2.82232893157263 0.571428571428571 25.2 25 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.82746168339789e-05 0.000142102621610666 2.79165144318597 0.565217391304348 25.2 25 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 4.86687716861893e-07 6.5957773437569e-06 2.77823004201681 0.5625 25.2 25 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000395211381174234 0.00202697212417315 2.77823004201681 0.5625 25.2 25 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.00027926049327e-05 8.52333765078996e-05 2.76588235294118 0.56 25.2 25 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.00027926049327e-05 8.52333765078996e-05 2.76588235294118 0.56 25.2 25 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00934801701096855 0.0298939886712476 2.74393090569561 0.555555555555556 25.2 25 2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.00934801701096855 0.0298939886712476 2.74393090569561 0.555555555555556 25.2 25 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00934801701096855 0.0298939886712476 2.74393090569561 0.555555555555556 25.2 25 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000114935877734212 0.000736728621692718 2.71649159663865 0.55 25.2 25 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 6.21889931070837e-05 0.000427511773871401 2.69404125286478 0.545454545454545 25.2 25 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00485150717522115 0.0173459666088937 2.69404125286478 0.545454545454545 25.2 25 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00485150717522115 0.0173459666088937 2.69404125286478 0.545454545454545 25.2 25 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 3.37130853409524e-05 0.000242291517374622 2.67533263305322 0.541666666666667 25.2 25 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.47517815054618e-08 4.75970068679354e-07 2.63417366946779 0.533333333333333 25.2 25 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00134404015427173 0.00568276971292196 2.63417366946779 0.533333333333333 25.2 25 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00134404015427173 0.00568276971292196 2.63417366946779 0.533333333333333 25.2 25 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 1.61386813014842e-06 1.77100361376251e-05 2.61480474542758 0.529411764705882 25.2 25 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.61386813014842e-06 1.77100361376251e-05 2.61480474542758 0.529411764705882 25.2 25 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000714435123167162 0.00336636152406249 2.61480474542758 0.529411764705882 25.2 25 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000714435123167162 0.00336636152406249 2.61480474542758 0.529411764705882 25.2 25 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000381600194405239 0.00202618312178603 2.59951348960637 0.526315789473684 25.2 25 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000381600194405239 0.00202618312178603 2.59951348960637 0.526315789473684 25.2 25 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 2.6397968055769e-07 3.87260912818136e-06 2.59301470588235 0.525 25.2 25 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 2.6397968055769e-07 3.87260912818136e-06 2.59301470588235 0.525 25.2 25 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.31308773725643e-14 3.28718428265909e-12 2.5844000390854 0.523255813953488 25.2 25 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.93460367011399e-11 5.29411735110039e-10 2.57690902447936 0.521739130434783 25.2 25 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000110095585405016 0.000712118263778811 2.57690902447936 0.521739130434783 25.2 25 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000110095585405016 0.000712118263778811 2.57690902447936 0.521739130434783 25.2 25 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 7.46335352985511e-08 1.27956049072094e-06 2.52208117289469 0.51063829787234 25.2 25 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.87019751267312e-10 4.36277223038335e-09 2.50639658848614 0.507462686567164 25.2 25 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.03541511358184e-09 2.23241773731356e-08 2.46953781512605 0.5 25.2 25 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 3.76799616625262e-08 6.96345265529542e-07 2.46953781512605 0.5 25.2 25 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 1.25407657251792e-07 1.96944864614082e-06 2.46953781512605 0.5 25.2 25 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000100491294515884 0.00065595922979864 2.46953781512605 0.5 25.2 25 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000100491294515884 0.00065595922979864 2.46953781512605 0.5 25.2 25 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00018647808546908 0.00111028583942469 2.46953781512605 0.5 25.2 25 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00018647808546908 0.00111028583942469 2.46953781512605 0.5 25.2 25 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00229286892736921 0.00916503506642244 2.46953781512605 0.5 25.2 25 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.00229286892736921 0.00916503506642244 2.46953781512605 0.5 25.2 25 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00229286892736921 0.00916503506642244 2.46953781512605 0.5 25.2 25 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00832977501492053 0.027369906218374 2.46953781512605 0.5 25.2 25 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00832977501492053 0.027369906218374 2.46953781512605 0.5 25.2 25 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00832977501492053 0.027369906218374 2.46953781512605 0.5 25.2 25 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00832977501492053 0.027369906218374 2.46953781512605 0.5 25.2 25 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 8.10324902887861e-13 3.84364112269809e-11 2.46953781512605 0.5 25.2 25 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 4.71593902676154e-06 4.35765015265044e-05 2.46953781512605 0.5 25.2 25 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00121599517181613 0.00532418809075185 2.46953781512605 0.5 25.2 25 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00121599517181613 0.00532418809075185 2.46953781512605 0.5 25.2 25 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00435181904922589 0.0161687689479072 2.46953781512605 0.5 25.2 25 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00435181904922589 0.0161687689479072 2.46953781512605 0.5 25.2 25 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00435181904922589 0.0161687689479072 2.46953781512605 0.5 25.2 25 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00435181904922589 0.0161687689479072 2.46953781512605 0.5 25.2 25 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0161255563251702 0.047118412013793 2.46953781512605 0.5 25.2 25 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0161255563251702 0.047118412013793 2.46953781512605 0.5 25.2 25 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0161255563251702 0.047118412013793 2.46953781512605 0.5 25.2 25 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0161255563251702 0.047118412013793 2.46953781512605 0.5 25.2 25 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0161255563251702 0.047118412013793 2.46953781512605 0.5 25.2 25 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0161255563251702 0.047118412013793 2.46953781512605 0.5 25.2 25 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0161255563251702 0.047118412013793 2.46953781512605 0.5 25.2 25 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.25468907072182e-13 1.1063526026335e-11 2.44354268022999 0.494736842105263 25.2 25 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.25468907072182e-13 1.1063526026335e-11 2.44354268022999 0.494736842105263 25.2 25 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.25468907072182e-13 1.1063526026335e-11 2.44354268022999 0.494736842105263 25.2 25 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.43154913860902e-12 9.88598406925897e-11 2.44115232299816 0.494252873563218 25.2 25 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.04931238214968e-14 6.7871432718136e-13 2.42380563336446 0.490740740740741 25.2 25 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.8864702416262e-07 8.90858832166734e-06 2.41465919701214 0.488888888888889 25.2 25 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 9.4426223365344e-15 6.39850075470879e-13 2.40279354985237 0.486486486486487 25.2 25 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 2.61189166125053e-05 0.000195616938629447 2.39470333587981 0.484848484848485 25.2 25 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 4.80944325435017e-05 0.000333845743948307 2.38987530496069 0.483870967741935 25.2 25 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000303781639005177 0.00165625008545735 2.37075630252101 0.48 25.2 25 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000303781639005177 0.00165625008545735 2.37075630252101 0.48 25.2 25 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.35786154389928e-09 2.88393578652041e-08 2.36519114688129 0.47887323943662 25.2 25 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.10996671484917e-06 1.37346316106988e-05 2.36216660577274 0.478260869565217 25.2 25 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.10996671484917e-06 1.37346316106988e-05 2.36216660577274 0.478260869565217 25.2 25 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00105156726209284 0.00472044231532528 2.35194077631052 0.476190476190476 25.2 25 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00105156726209284 0.00472044231532528 2.35194077631052 0.476190476190476 25.2 25 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00196695065148593 0.00804024724123141 2.33956214064573 0.473684210526316 25.2 25 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 4.16328724725392e-05 0.000291840283391248 2.32427088482452 0.470588235294118 25.2 25 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00369592119777104 0.0140999889126761 2.32427088482452 0.470588235294118 25.2 25 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00369592119777104 0.0140999889126761 2.32427088482452 0.470588235294118 25.2 25 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 7.64596201456957e-05 0.000523086728208293 2.31519170168067 0.46875 25.2 25 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 9.08458705561849e-15 6.39850075470879e-13 2.31021279479534 0.467741935483871 25.2 25 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 9.08458705561849e-15 6.39850075470879e-13 2.31021279479534 0.467741935483871 25.2 25 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 9.08458705561849e-15 6.39850075470879e-13 2.31021279479534 0.467741935483871 25.2 25 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000140619722446125 0.000881506013395755 2.30490196078431 0.466666666666667 25.2 25 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00698362558231078 0.0236611885800672 2.30490196078431 0.466666666666667 25.2 25 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00698362558231078 0.0236611885800672 2.30490196078431 0.466666666666667 25.2 25 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00698362558231078 0.0236611885800672 2.30490196078431 0.466666666666667 25.2 25 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00698362558231078 0.0236611885800672 2.30490196078431 0.466666666666667 25.2 25 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.57780724090697e-25 1.69707323460354e-22 2.30342540603685 0.466367713004484 25.2 25 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000259033898415411 0.00144551073507894 2.29314225690276 0.464285714285714 25.2 25 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000478030505710287 0.00238679792851136 2.27957336780866 0.461538461538462 25.2 25 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0132892342549651 0.040493748061703 2.27957336780866 0.461538461538462 25.2 25 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0132892342549651 0.040493748061703 2.27957336780866 0.461538461538462 25.2 25 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0132892342549651 0.040493748061703 2.27957336780866 0.461538461538462 25.2 25 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0132892342549651 0.040493748061703 2.27957336780866 0.461538461538462 25.2 25 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 3.54145465478603e-05 0.000253240702199021 2.26930501930502 0.459459459459459 25.2 25 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000118410206423354 0.000755595173723913 2.24503437738732 0.454545454545455 25.2 25 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 8.99321925750945e-06 7.80326280697314e-05 2.24503437738732 0.454545454545455 25.2 25 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0255205972834611 0.0689104552834253 2.24503437738732 0.454545454545455 25.2 25 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0255205972834611 0.0689104552834253 2.24503437738732 0.454545454545455 25.2 25 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.63454439068051e-05 0.000129219814885465 2.234343737495 0.452380952380952 25.2 25 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00304587567545748 0.0117779377341739 2.22258403361345 0.45 25.2 25 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00304587567545748 0.0117779377341739 2.22258403361345 0.45 25.2 25 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00304587567545748 0.0117779377341739 2.22258403361345 0.45 25.2 25 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000397417584430294 0.00202697212417315 2.21406838597508 0.448275862068966 25.2 25 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.36303558984101e-05 0.000111471243927802 2.19514472455649 0.444444444444444 25.2 25 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00567986201853497 0.0198585839124699 2.19514472455649 0.444444444444444 25.2 25 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00567986201853497 0.0198585839124699 2.19514472455649 0.444444444444444 25.2 25 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00567986201853497 0.0198585839124699 2.19514472455649 0.444444444444444 25.2 25 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00567986201853497 0.0198585839124699 2.19514472455649 0.444444444444444 25.2 25 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.02668439044315e-20 1.62330209733401e-18 2.18730492196879 0.442857142857143 25.2 25 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 2.46729804268994e-05 0.000186753463550414 2.18238225522767 0.441860465116279 25.2 25 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 6.24968016922014e-06 5.54324913833663e-05 2.17319327731092 0.44 25.2 25 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00133989150261445 0.00568276971292196 2.17319327731092 0.44 25.2 25 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00133989150261445 0.00568276971292196 2.17319327731092 0.44 25.2 25 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00133989150261445 0.00568276971292196 2.17319327731092 0.44 25.2 25 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 6.96754254885147e-14 4.13117210292318e-12 2.1675080103984 0.438848920863309 25.2 25 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 1.59447319998034e-06 1.77100361376251e-05 2.16626124133864 0.43859649122807 25.2 25 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 5.885334794509e-08 1.07369633494696e-06 2.16507424887763 0.438356164383562 25.2 25 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0106319918694876 0.0332512624841337 2.16084558823529 0.4375 25.2 25 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0106319918694876 0.0332512624841337 2.16084558823529 0.4375 25.2 25 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0106319918694876 0.0332512624841337 2.16084558823529 0.4375 25.2 25 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0106319918694876 0.0332512624841337 2.16084558823529 0.4375 25.2 25 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.03077549592851e-05 0.000156205055713852 2.14742418706613 0.434782608695652 25.2 25 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00246506102359871 0.00979827328653902 2.14742418706613 0.434782608695652 25.2 25 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00246506102359871 0.00979827328653902 2.14742418706613 0.434782608695652 25.2 25 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 5.14913667596284e-06 4.69693685249688e-05 2.14337244331695 0.433962264150943 25.2 25 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.31466606902933e-06 1.52095107010466e-05 2.14026610644258 0.433333333333333 25.2 25 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.31466606902933e-06 1.52095107010466e-05 2.14026610644258 0.433333333333333 25.2 25 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.31466606902933e-06 1.52095107010466e-05 2.14026610644258 0.433333333333333 25.2 25 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.31466606902933e-06 1.52095107010466e-05 2.14026610644258 0.433333333333333 25.2 25 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.31466606902933e-06 1.52095107010466e-05 2.14026610644258 0.433333333333333 25.2 25 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.31466606902933e-06 1.52095107010466e-05 2.14026610644258 0.433333333333333 25.2 25 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.31466606902933e-06 1.52095107010466e-05 2.14026610644258 0.433333333333333 25.2 25 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 3.65895989156361e-05 0.000260334996284751 2.13278265851795 0.431818181818182 25.2 25 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000264745305744404 0.00146588548667038 2.11674669867947 0.428571428571429 25.2 25 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000264745305744404 0.00146588548667038 2.11674669867947 0.428571428571429 25.2 25 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.65976254917585e-05 0.000130488514225261 2.11674669867947 0.428571428571429 25.2 25 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00108195555125058 0.00484158097304899 2.11674669867947 0.428571428571429 25.2 25 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00454160698548094 0.016699500621032 2.11674669867947 0.428571428571429 25.2 25 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00454160698548094 0.016699500621032 2.11674669867947 0.428571428571429 25.2 25 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00454160698548094 0.016699500621032 2.11674669867947 0.428571428571429 25.2 25 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0199922956592694 0.0560020407935835 2.11674669867947 0.428571428571429 25.2 25 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0199922956592694 0.0560020407935835 2.11674669867947 0.428571428571429 25.2 25 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0199922956592694 0.0560020407935835 2.11674669867947 0.428571428571429 25.2 25 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0199922956592694 0.0560020407935835 2.11674669867947 0.428571428571429 25.2 25 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0199922956592694 0.0560020407935835 2.11674669867947 0.428571428571429 25.2 25 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0199922956592694 0.0560020407935835 2.11674669867947 0.428571428571429 25.2 25 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.97726779146082e-05 0.000218384127177771 2.10173431074558 0.425531914893617 25.2 25 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00197192290034418 0.00804024724123141 2.08960892049127 0.423076923076923 25.2 25 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00197192290034418 0.00804024724123141 2.08960892049127 0.423076923076923 25.2 25 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00197192290034418 0.00804024724123141 2.08960892049127 0.423076923076923 25.2 25 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 6.89168352524012e-12 2.65050423146397e-10 2.08960892049127 0.423076923076923 25.2 25 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.47429232434034e-12 6.35732720465545e-11 2.08146758703481 0.421428571428571 25.2 25 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.78685203628097e-13 1.01707617905113e-11 2.07961079168509 0.421052631578947 25.2 25 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00838016119457062 0.027369906218374 2.07961079168509 0.421052631578947 25.2 25 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 1.09059967563463e-05 9.07557507852674e-05 2.06543162719633 0.418181818181818 25.2 25 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.0897583057206e-11 8.14208531303781e-10 2.06118904254615 0.417322834645669 25.2 25 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000383596954807163 0.00202697212417315 2.05794817927171 0.416666666666667 25.2 25 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00359438806715039 0.0137865612386928 2.05794817927171 0.416666666666667 25.2 25 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0377997560467044 0.0932219286905725 2.05794817927171 0.416666666666667 25.2 25 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0377997560467044 0.0932219286905725 2.05794817927171 0.416666666666667 25.2 25 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0377997560467044 0.0932219286905725 2.05794817927171 0.416666666666667 25.2 25 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0377997560467044 0.0932219286905725 2.05794817927171 0.416666666666667 25.2 25 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0377997560467044 0.0932219286905725 2.05794817927171 0.416666666666667 25.2 25 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0377997560467044 0.0932219286905725 2.05794817927171 0.416666666666667 25.2 25 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0377997560467044 0.0932219286905725 2.05794817927171 0.416666666666667 25.2 25 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.25046418889226e-06 2.37215595614347e-05 2.0516160310278 0.415384615384615 25.2 25 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.49795313260427e-15 2.22161706730992e-13 2.05120080819213 0.415300546448087 25.2 25 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 1.94037854987118e-05 0.000150062971547103 2.05018233708578 0.415094339622642 25.2 25 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000171012551407456 0.00104127931228653 2.04790940766551 0.414634146341463 25.2 25 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000171012551407456 0.00104127931228653 2.04790940766551 0.414634146341463 25.2 25 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000171012551407456 0.00104127931228653 2.04790940766551 0.414634146341463 25.2 25 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000171012551407456 0.00104127931228653 2.04790940766551 0.414634146341463 25.2 25 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 3.98541283335093e-06 3.83192058233674e-05 2.03834867280245 0.412698412698413 25.2 25 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.13665635496695e-07 3.23453403523188e-06 2.03736869747899 0.4125 25.2 25 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 9.77239128632118e-08 1.6169898605157e-06 2.03373702422145 0.411764705882353 25.2 25 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 9.77239128632118e-08 1.6169898605157e-06 2.03373702422145 0.411764705882353 25.2 25 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 9.77239128632118e-08 1.6169898605157e-06 2.03373702422145 0.411764705882353 25.2 25 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0154872413396891 0.0459132175549533 2.03373702422145 0.411764705882353 25.2 25 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0154872413396891 0.0459132175549533 2.03373702422145 0.411764705882353 25.2 25 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.38802643112042e-10 5.48090582497476e-09 2.02421132387381 0.409836065573771 25.2 25 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.60177617317095e-08 6.74385196634507e-07 2.01811692418903 0.408602150537634 25.2 25 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.11930019658217e-05 0.000422706999016331 2.01594923683759 0.408163265306122 25.2 25 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.04814265542962e-12 4.81131289895598e-11 2.0133811486378 0.407643312101911 25.2 25 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0028262434398421 0.0110184778490283 2.01221599751012 0.407407407407407 25.2 25 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.3817799627902e-07 2.13725313809832e-06 2.01008891928865 0.406976744186047 25.2 25 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00123557301438722 0.00539331410881293 2.00649947478992 0.40625 25.2 25 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.56128234834596e-06 2.67992998654139e-05 2.00426257459506 0.405797101449275 25.2 25 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 5.3106996370171e-07 6.99733850321791e-06 2.00063822997553 0.40506329113924 25.2 25 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 5.3106996370171e-07 6.99733850321791e-06 2.00063822997553 0.40506329113924 25.2 25 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.50205501824151e-06 4.23114805224651e-05 1.99037376144488 0.402985074626866 25.2 25 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 4.59293285697927e-11 1.1466216588564e-09 1.98984341938214 0.402877697841727 25.2 25 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.04561716349461e-06 2.19432514135364e-05 1.98934990662932 0.402777777777778 25.2 25 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.06224466130167e-12 8.63110045009492e-11 1.98805559959833 0.40251572327044 25.2 25 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.40453161383842e-11 1.5446861841512e-09 1.97563025210084 0.4 25.2 25 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.000971618513025528 0.00440322657336091 1.97563025210084 0.4 25.2 25 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000971618513025528 0.00440322657336091 1.97563025210084 0.4 25.2 25 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.63036875195283e-06 1.77100361376251e-05 1.97563025210084 0.4 25.2 25 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.63036875195283e-06 1.77100361376251e-05 1.97563025210084 0.4 25.2 25 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.63036875195283e-06 1.77100361376251e-05 1.97563025210084 0.4 25.2 25 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.63036875195283e-06 1.77100361376251e-05 1.97563025210084 0.4 25.2 25 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.63036875195283e-06 1.77100361376251e-05 1.97563025210084 0.4 25.2 25 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00221273642320193 0.00894523843811463 1.97563025210084 0.4 25.2 25 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00221273642320193 0.00894523843811463 1.97563025210084 0.4 25.2 25 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0286647423772419 0.0752581704848989 1.97563025210084 0.4 25.2 25 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0286647423772419 0.0752581704848989 1.97563025210084 0.4 25.2 25 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.87445092775039e-12 1.13620657505245e-10 1.97563025210084 0.4 25.2 25 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000430274517525682 0.00218671656585373 1.97563025210084 0.4 25.2 25 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.0119363515406461 0.0369248440050855 1.97563025210084 0.4 25.2 25 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0119363515406461 0.0369248440050855 1.97563025210084 0.4 25.2 25 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0119363515406461 0.0369248440050855 1.97563025210084 0.4 25.2 25 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0119363515406461 0.0369248440050855 1.97563025210084 0.4 25.2 25 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.3840652416288e-05 0.000112544276505016 1.95995064692544 0.396825396825397 25.2 25 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000151302337466886 0.000944312395681489 1.95505077030812 0.395833333333333 25.2 25 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.28865169404513e-10 1.62058615009785e-08 1.95265780730897 0.395348837209302 25.2 25 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 7.17210060490404e-19 1.02058991607784e-16 1.942945192783 0.393382352941176 25.2 25 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.73083433516783e-07 5.25641312766715e-06 1.94233311302049 0.393258426966292 25.2 25 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.07253848453437e-07 1.75427846378438e-06 1.92623949579832 0.39 25.2 25 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00134581405007358 0.00568276971292196 1.92075163398693 0.388888888888889 25.2 25 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00134581405007358 0.00568276971292196 1.92075163398693 0.388888888888889 25.2 25 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.00134581405007358 0.00568276971292196 1.92075163398693 0.388888888888889 25.2 25 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0217283009076963 0.0595748982498107 1.92075163398693 0.388888888888889 25.2 25 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0217283009076963 0.0595748982498107 1.92075163398693 0.388888888888889 25.2 25 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0217283009076963 0.0595748982498107 1.92075163398693 0.388888888888889 25.2 25 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0217283009076963 0.0595748982498107 1.92075163398693 0.388888888888889 25.2 25 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0217283009076963 0.0595748982498107 1.92075163398693 0.388888888888889 25.2 25 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 3.32118097406516e-05 0.000239900534319529 1.91190024396856 0.387096774193548 25.2 25 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000465811586549302 0.00234222575144755 1.90827922077922 0.386363636363636 25.2 25 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000465811586549302 0.00234222575144755 1.90827922077922 0.386363636363636 25.2 25 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.43837780921464e-08 4.75316660618142e-07 1.906309892378 0.385964912280702 25.2 25 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.18461518196302e-05 9.74397343314092e-05 1.90507202881152 0.385714285714286 25.2 25 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.15638578006892e-07 1.85239129116927e-06 1.89964447317389 0.384615384615385 25.2 25 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00104707862213864 0.00472044231532528 1.89964447317389 0.384615384615385 25.2 25 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00705080007465155 0.0238320392071951 1.89964447317389 0.384615384615385 25.2 25 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0531188321665415 0.123509964334949 1.89964447317389 0.384615384615385 25.2 25 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0531188321665415 0.123509964334949 1.89964447317389 0.384615384615385 25.2 25 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0531188321665415 0.123509964334949 1.89964447317389 0.384615384615385 25.2 25 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0531188321665415 0.123509964334949 1.89964447317389 0.384615384615385 25.2 25 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 9.3149658285663e-06 8.03345234790899e-05 1.89443996776793 0.383561643835616 25.2 25 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 3.33902473453902e-06 3.36981006897094e-05 1.89026351281253 0.382716049382716 25.2 25 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.07668900187027e-11 5.57571405596489e-10 1.88847009391992 0.382352941176471 25.2 25 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.2010674884362e-08 2.44159862292102e-07 1.88728906196625 0.382113821138211 25.2 25 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000813871030772787 0.00379717533373664 1.88155262104842 0.380952380952381 25.2 25 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 4.51325219402597e-05 0.000314821464318576 1.88155262104842 0.380952380952381 25.2 25 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.66241404000135e-10 3.94269196486987e-09 1.87559834060206 0.379746835443038 25.2 25 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 5.7449219966608e-06 5.17406582357488e-05 1.87559834060206 0.379746835443038 25.2 25 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 9.96881359846704e-05 0.00065595922979864 1.87344248044045 0.379310344827586 25.2 25 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 9.96881359846704e-05 0.00065595922979864 1.87344248044045 0.379310344827586 25.2 25 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00541529788430952 0.0192168800233727 1.87344248044045 0.379310344827586 25.2 25 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.52353043387728e-16 2.56498843386241e-14 1.87344248044045 0.379310344827586 25.2 25 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.61965476517342e-08 3.24615314203067e-07 1.87206898888588 0.379032258064516 25.2 25 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.77908442212901e-11 1.17252364356717e-09 1.87041917358659 0.378698224852071 25.2 25 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.74304963624058e-11 5.29411735110039e-10 1.86959360015193 0.378531073446328 25.2 25 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 7.78443691893397e-05 0.000524988328703462 1.86227441796391 0.377049180327869 25.2 25 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 7.78443691893397e-05 0.000524988328703462 1.86227441796391 0.377049180327869 25.2 25 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 7.78443691893397e-05 0.000524988328703462 1.86227441796391 0.377049180327869 25.2 25 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 5.76748760394028e-16 5.47142324027134e-14 1.86165158371041 0.376923076923077 25.2 25 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.76314090895656e-05 0.000204789037158603 1.86110096212398 0.376811594202899 25.2 25 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.53351738545578e-06 3.42054097925413e-05 1.85941670785961 0.376470588235294 25.2 25 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.53351738545578e-06 3.42054097925413e-05 1.85941670785961 0.376470588235294 25.2 25 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.53351738545578e-06 3.42054097925413e-05 1.85941670785961 0.376470588235294 25.2 25 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.53351738545578e-06 3.42054097925413e-05 1.85941670785961 0.376470588235294 25.2 25 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.53351738545578e-06 3.42054097925413e-05 1.85941670785961 0.376470588235294 25.2 25 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.53351738545578e-06 3.42054097925413e-05 1.85941670785961 0.376470588235294 25.2 25 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 2.76893424824105e-06 2.87605360237008e-05 1.85215336134454 0.375 25.2 25 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000490831275174693 0.00242518369643607 1.85215336134454 0.375 25.2 25 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0041598940814469 0.0157434289305823 1.85215336134454 0.375 25.2 25 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0125285669832493 0.0385890710328221 1.85215336134454 0.375 25.2 25 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0394843926818946 0.0962094020313973 1.85215336134454 0.375 25.2 25 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0394843926818946 0.0962094020313973 1.85215336134454 0.375 25.2 25 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0394843926818946 0.0962094020313973 1.85215336134454 0.375 25.2 25 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.16013353559351e-05 0.000165261829094063 1.85215336134454 0.375 25.2 25 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000171961095142189 0.00104127931228653 1.85215336134454 0.375 25.2 25 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000171961095142189 0.00104127931228653 1.85215336134454 0.375 25.2 25 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.82052203275669e-07 4.05414429556846e-06 1.84638341317836 0.373831775700935 25.2 25 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000133857970316299 0.000850356659643276 1.84168921806011 0.372881355932203 25.2 25 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.11740457375869e-13 1.1063526026335e-11 1.8383106605871 0.37219730941704 25.2 25 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 6.28000367631852e-08 1.08981039407332e-06 1.83684630877144 0.371900826446281 25.2 25 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 6.28000367631852e-08 1.08981039407332e-06 1.83684630877144 0.371900826446281 25.2 25 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 6.28000367631852e-08 1.08981039407332e-06 1.83684630877144 0.371900826446281 25.2 25 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.2490211966393e-21 4.57193880402532e-19 1.83564575562845 0.371657754010695 25.2 25 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 3.69590611127091e-05 0.000261655442603906 1.83451380552221 0.371428571428571 25.2 25 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.24839601819147e-12 5.55146104339521e-11 1.83451380552221 0.371428571428571 25.2 25 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 5.09482248839901e-09 1.06616652955762e-07 1.8305664923312 0.370629370629371 25.2 25 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.02948884553914e-05 8.66841791243904e-05 1.82928727046374 0.37037037037037 25.2 25 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.02948884553914e-05 8.66841791243904e-05 1.82928727046374 0.37037037037037 25.2 25 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00953583338924532 0.0304248675177042 1.82928727046374 0.37037037037037 25.2 25 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.88636765168922e-06 2.9548929268732e-05 1.82531055900621 0.369565217391304 25.2 25 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000846948027790263 0.00393858510962596 1.82531055900621 0.369565217391304 25.2 25 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0295147157403529 0.07706319357527 1.81965944272446 0.368421052631579 25.2 25 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 7.01433533051773e-10 1.58434907544869e-08 1.81806464917255 0.368098159509202 25.2 25 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 6.27170141442163e-06 5.54324913833663e-05 1.81667149618468 0.367816091954023 25.2 25 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 6.27170141442163e-06 5.54324913833663e-05 1.81667149618468 0.367816091954023 25.2 25 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000654840128530447 0.00315877119626721 1.81435431315383 0.36734693877551 25.2 25 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.89353240704403e-06 4.49257846143462e-05 1.8109943977591 0.366666666666667 25.2 25 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00726941241442444 0.0243397032134729 1.8109943977591 0.366666666666667 25.2 25 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00189079122475163 0.00782149974657434 1.80697888911662 0.365853658536585 25.2 25 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 6.54857708047073e-07 8.54919741789895e-06 1.79602750190986 0.363636363636364 25.2 25 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000391682761364274 0.00202697212417315 1.79602750190986 0.363636363636364 25.2 25 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000391682761364274 0.00202697212417315 1.79602750190986 0.363636363636364 25.2 25 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000391682761364274 0.00202697212417315 1.79602750190986 0.363636363636364 25.2 25 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00554989693964431 0.0196455307092384 1.79602750190986 0.363636363636364 25.2 25 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0221644571037193 0.060421498962821 1.79602750190985 0.363636363636364 25.2 25 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.1113317310711e-27 1.50221252665709e-24 1.7934666261942 0.363117870722433 25.2 25 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 8.31593955927344e-05 0.000558187829851231 1.78952015588844 0.36231884057971 25.2 25 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000303025969313602 0.00165625008545735 1.7882860040568 0.362068965517241 25.2 25 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000303025969313602 0.00165625008545735 1.7882860040568 0.362068965517241 25.2 25 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00424295541597181 0.0159728189336717 1.78355508870215 0.361111111111111 25.2 25 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.016708606411854 0.0487220223853857 1.77806722689076 0.36 25.2 25 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000181505673286612 0.0010897998864424 1.77498030462185 0.359375 25.2 25 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000665979872694488 0.00318685275127849 1.77061201839226 0.358490566037736 25.2 25 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.000140526457067087 0.000881506013395755 1.76922112128433 0.358208955223881 25.2 25 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0126363517671979 0.0388369947402216 1.76395558223289 0.357142857142857 25.2 25 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0715224635594705 0.158236846077343 1.76395558223289 0.357142857142857 25.2 25 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0715224635594705 0.158236846077343 1.76395558223289 0.357142857142857 25.2 25 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0715224635594705 0.158236846077343 1.76395558223289 0.357142857142857 25.2 25 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0715224635594705 0.158236846077343 1.76395558223289 0.357142857142857 25.2 25 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0715224635594705 0.158236846077343 1.76395558223289 0.357142857142857 25.2 25 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.000396513547706852 0.00202697212417315 1.75797607178465 0.355932203389831 25.2 25 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.000396513547706852 0.00202697212417315 1.75797607178465 0.355932203389831 25.2 25 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.19317986614378e-15 6.39850075470879e-13 1.75311899503829 0.354948805460751 25.2 25 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000306173660233013 0.00166292029966251 1.75257522363784 0.354838709677419 25.2 25 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00958278871764311 0.0305062826514679 1.75257522363784 0.354838709677419 25.2 25 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 8.84476863276518e-21 1.57326322055311e-18 1.75070521166213 0.354460093896714 25.2 25 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.20389695301326e-07 4.55914536413787e-06 1.75006616819956 0.354330708661417 25.2 25 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00146641756424923 0.00611939059802537 1.74925595238095 0.354166666666667 25.2 25 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.92342038737839e-05 0.000276387485704923 1.7467462594794 0.353658536585366 25.2 25 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 6.62040899504073e-06 5.81533456786603e-05 1.74613784907903 0.353535353535354 25.2 25 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.04185923767707e-05 0.000220845188531351 1.74320316361839 0.352941176470588 25.2 25 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00112710773090974 0.0049655551117169 1.74320316361839 0.352941176470588 25.2 25 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 7.91307131371655e-10 1.73235391991056e-08 1.74320316361839 0.352941176470588 25.2 25 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0525737479594612 0.123046781819594 1.74320316361839 0.352941176470588 25.2 25 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0525737479594612 0.123046781819594 1.74320316361839 0.352941176470588 25.2 25 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0525737479594612 0.123046781819594 1.74320316361839 0.352941176470588 25.2 25 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0525737479594612 0.123046781819594 1.74320316361839 0.352941176470588 25.2 25 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000867019497916382 0.00395438700491991 1.73782290694055 0.351851851851852 25.2 25 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000867019497916382 0.00395438700491991 1.73782290694055 0.351851851851852 25.2 25 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000867019497916382 0.00395438700491991 1.73782290694055 0.351851851851852 25.2 25 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000514176230217292 0.00251433943504882 1.72867647058824 0.35 25.2 25 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.000514176230217292 0.00251433943504882 1.72867647058824 0.35 25.2 25 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00423367278348761 0.0159728189336717 1.72867647058824 0.35 25.2 25 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0389799887709643 0.0954707814476457 1.72867647058824 0.35 25.2 25 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0389799887709643 0.0954707814476457 1.72867647058824 0.35 25.2 25 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0389799887709643 0.0954707814476457 1.72867647058824 0.35 25.2 25 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 8.81044156655551e-07 1.11939806689361e-05 1.72666871626699 0.349593495934959 25.2 25 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.000396353912654848 0.00202697212417315 1.72475656929438 0.349206349206349 25.2 25 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0290904342845231 0.076095014681758 1.7179393496529 0.347826086956522 25.2 25 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0290904342845231 0.076095014681758 1.7179393496529 0.347826086956522 25.2 25 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.41534510486142e-05 0.000113148094618978 1.71355685131195 0.346938775510204 25.2 25 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.02182156270802 0.0596009284712332 1.7096800258565 0.346153846153846 25.2 25 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.02182156270802 0.0596009284712332 1.7096800258565 0.346153846153846 25.2 25 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00111789166443 0.00494024794560214 1.70622612681436 0.345454545454545 25.2 25 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00111789166443 0.00494024794560214 1.70622612681436 0.345454545454545 25.2 25 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00111789166443 0.00494024794560214 1.70622612681436 0.345454545454545 25.2 25 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000859254066619597 0.00395438700491991 1.70312952767314 0.344827586206897 25.2 25 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000859254066619597 0.00395438700491991 1.70312952767314 0.344827586206897 25.2 25 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000859254066619597 0.00395438700491991 1.70312952767314 0.344827586206897 25.2 25 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000508893466609634 0.00250572803801214 1.69780724789916 0.34375 25.2 25 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.80938115074062e-05 0.000141469746016698 1.6962481962482 0.343434343434343 25.2 25 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.000392058762180147 0.00202697212417315 1.69550357456415 0.343283582089552 25.2 25 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.000392058762180147 0.00202697212417315 1.69550357456415 0.343283582089552 25.2 25 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 7.38757219990911e-09 1.52355293340155e-07 1.69109654731458 0.342391304347826 25.2 25 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000179937879317856 0.00108496441639538 1.68968376824414 0.342105263157895 25.2 25 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00715537741329236 0.0240143916488562 1.68968376824414 0.342105263157895 25.2 25 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00715537741329236 0.0240143916488562 1.68968376824414 0.342105263157895 25.2 25 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.15855815118809e-07 1.85239129116927e-06 1.68884521550556 0.341935483870968 25.2 25 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.30121851585645e-05 0.000175114114869718 1.67928571428571 0.34 25.2 25 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.0700602403677e-05 8.9570336590779e-05 1.67656695705805 0.339449541284404 25.2 25 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 8.29431542465468e-06 7.24098825109424e-05 1.67575780312125 0.339285714285714 25.2 25 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.08668893921938e-35 4.39235836050917e-32 1.66498250884064 0.33710407239819 25.2 25 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.78272222398794e-07 5.27726835758318e-06 1.64635854341737 0.333333333333333 25.2 25 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 2.83861873700376e-05 0.000209292977344888 1.64635854341737 0.333333333333333 25.2 25 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.000374124404448562 0.00200142491552746 1.64635854341737 0.333333333333333 25.2 25 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00048553811203093 0.00240738931505231 1.64635854341737 0.333333333333333 25.2 25 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00048553811203093 0.00240738931505231 1.64635854341737 0.333333333333333 25.2 25 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00692821027687832 0.0236611885800672 1.64635854341737 0.333333333333333 25.2 25 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0279644273674073 0.0745000743796959 1.64635854341737 0.333333333333333 25.2 25 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0279644273674073 0.0745000743796959 1.64635854341737 0.333333333333333 25.2 25 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0279644273674073 0.0745000743796959 1.64635854341737 0.333333333333333 25.2 25 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0279644273674073 0.0745000743796959 1.64635854341737 0.333333333333333 25.2 25 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0279644273674073 0.0745000743796959 1.64635854341737 0.333333333333333 25.2 25 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0279644273674073 0.0745000743796959 1.64635854341737 0.333333333333333 25.2 25 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.03737136793516 0.0932219286905725 1.64635854341737 0.333333333333333 25.2 25 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.03737136793516 0.0932219286905725 1.64635854341737 0.333333333333333 25.2 25 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.03737136793516 0.0932219286905725 1.64635854341737 0.333333333333333 25.2 25 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.03737136793516 0.0932219286905725 1.64635854341737 0.333333333333333 25.2 25 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0502265013691494 0.118331641470695 1.64635854341737 0.333333333333333 25.2 25 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0679964714853434 0.152857786609232 1.64635854341737 0.333333333333333 25.2 25 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0679964714853434 0.152857786609232 1.64635854341737 0.333333333333333 25.2 25 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0929513241505847 0.18977006350973 1.64635854341737 0.333333333333333 25.2 25 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0929513241505847 0.18977006350973 1.64635854341737 0.333333333333333 25.2 25 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0929513241505847 0.18977006350973 1.64635854341737 0.333333333333333 25.2 25 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0929513241505847 0.18977006350973 1.64635854341737 0.333333333333333 25.2 25 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0929513241505847 0.18977006350973 1.64635854341737 0.333333333333333 25.2 25 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.94248001236125e-17 5.4485995837177e-15 1.62790160907412 0.329596412556054 25.2 25 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.61186727447422e-07 9.75827669511425e-06 1.62511520737327 0.329032258064516 25.2 25 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000469313877551852 0.00235152692871932 1.62469593100398 0.328947368421053 25.2 25 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000609160897087047 0.00295848449336132 1.62380568665822 0.328767123287671 25.2 25 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.00663639514414864 0.0228658360535678 1.6105681402996 0.326086956521739 25.2 25 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 9.12851003128668e-07 1.14954599774522e-05 1.60519957983193 0.325 25.2 25 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0151023622483099 0.0450537976506183 1.60186236656825 0.324324324324324 25.2 25 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0151023622483099 0.0450537976506183 1.60186236656825 0.324324324324324 25.2 25 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0151023622483099 0.0450537976506183 1.60186236656825 0.324324324324324 25.2 25 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0199615730121857 0.0560020407935835 1.59793623331686 0.323529411764706 25.2 25 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0199615730121857 0.0560020407935835 1.59793623331686 0.323529411764706 25.2 25 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0199615730121857 0.0560020407935835 1.59793623331686 0.323529411764706 25.2 25 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.39226850273425e-07 3.58336639935878e-06 1.59237957478073 0.322404371584699 25.2 25 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0352250947569801 0.0899915796035595 1.5875600240096 0.321428571428571 25.2 25 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0352250947569801 0.0899915796035595 1.5875600240096 0.321428571428571 25.2 25 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.97763841098596e-17 5.4485995837177e-15 1.58612591378015 0.321138211382114 25.2 25 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.41521970509639e-05 0.000113148094618978 1.58352043107319 0.320610687022901 25.2 25 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.41521970509639e-05 0.000113148094618978 1.58352043107319 0.320610687022901 25.2 25 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0063046666717437 0.0218818065216861 1.58050420168067 0.32 25.2 25 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0470950204167157 0.113012165350736 1.58050420168067 0.32 25.2 25 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0470950204167157 0.113012165350736 1.58050420168067 0.32 25.2 25 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 5.98865641039878e-08 1.07871621164525e-06 1.57580032012805 0.319047619047619 25.2 25 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 2.83442098052161e-06 2.92273989513207e-05 1.57295402237328 0.318471337579618 25.2 25 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 3.46759945165483e-08 6.5791920262731e-07 1.57152406417112 0.318181818181818 25.2 25 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0633221220263503 0.144629784570031 1.57152406417112 0.318181818181818 25.2 25 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0633221220263503 0.144629784570031 1.57152406417112 0.318181818181818 25.2 25 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0633221220263503 0.144629784570031 1.57152406417112 0.318181818181818 25.2 25 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.6908224001574e-07 3.90718395451427e-06 1.56918548669468 0.317708333333333 25.2 25 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.000139867654522639 0.000881506013395755 1.56720669036846 0.317307692307692 25.2 25 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0142460111474063 0.0428585071094274 1.56604837056774 0.317073170731707 25.2 25 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0142460111474063 0.0428585071094274 1.56604837056774 0.317073170731707 25.2 25 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0142460111474063 0.0428585071094274 1.56604837056774 0.317073170731707 25.2 25 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0142460111474063 0.0428585071094274 1.56604837056774 0.317073170731707 25.2 25 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0142460111474063 0.0428585071094274 1.56604837056774 0.317073170731707 25.2 25 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.97608763731398e-17 2.55633882536163e-15 1.56311569571649 0.316479400749064 25.2 25 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0187702014029333 0.0537424478800284 1.55970809376382 0.315789473684211 25.2 25 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0857572818291855 0.181372635341153 1.55970809376382 0.315789473684211 25.2 25 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0857572818291855 0.181372635341153 1.55970809376382 0.315789473684211 25.2 25 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0857572818291855 0.181372635341153 1.55970809376382 0.315789473684211 25.2 25 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0857572818291855 0.181372635341153 1.55970809376382 0.315789473684211 25.2 25 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.000652573656179398 0.00315854528143974 1.55064002345124 0.313953488372093 25.2 25 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00777804757154052 0.0258601908745378 1.54951392321635 0.313725490196078 25.2 25 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00777804757154052 0.0258601908745378 1.54951392321635 0.313725490196078 25.2 25 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0101802832952899 0.0322640158779455 1.54346113445378 0.3125 25.2 25 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0101802832952899 0.0322640158779455 1.54346113445378 0.3125 25.2 25 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.117254474818171 0.227630447020814 1.54346113445378 0.3125 25.2 25 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.117254474818171 0.227630447020814 1.54346113445378 0.3125 25.2 25 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.117254474818171 0.227630447020814 1.54346113445378 0.3125 25.2 25 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.117254474818171 0.227630447020814 1.54346113445378 0.3125 25.2 25 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.117254474818171 0.227630447020814 1.54346113445378 0.3125 25.2 25 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.117254474818171 0.227630447020814 1.54346113445378 0.3125 25.2 25 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.117254474818171 0.227630447020814 1.54346113445378 0.3125 25.2 25 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.00227680538834e-23 2.37706649011268e-21 1.54306588192255 0.312419974391805 25.2 25 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 9.21631730853529e-05 0.000615145599675366 1.53567897747334 0.310924369747899 25.2 25 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.00183789136939309 0.00762483795523724 1.53511810129457 0.310810810810811 25.2 25 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.00183789136939309 0.00762483795523724 1.53511810129457 0.310810810810811 25.2 25 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0436797794985403 0.105708037800039 1.53281657490582 0.310344827586207 25.2 25 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.000347889898789474 0.00188230922424875 1.53111344537815 0.31 25.2 25 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000197036336267055 0.00111262978773024 1.52662337662338 0.309090909090909 25.2 25 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0013328208208525 0.00568276971292196 1.52440605871978 0.308641975308642 25.2 25 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0230640156818163 0.0627535264153435 1.51971557853911 0.307692307692308 25.2 25 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00522656275040477 0.018593496984565 1.51358769314177 0.306451612903226 25.2 25 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.0124371071175577 0.0383904629680795 1.51196192762819 0.306122448979592 25.2 25 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00124946618447913 0.00542070237961526 1.51077607513594 0.305882352941176 25.2 25 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00124946618447913 0.00542070237961526 1.51077607513594 0.305882352941176 25.2 25 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00680023280730924 0.0233737470647368 1.50683663295827 0.305084745762712 25.2 25 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.11003719052628e-05 9.18362164022616e-05 1.50581574093052 0.304878048780488 25.2 25 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00375491573665599 0.0142867515862606 1.50319693094629 0.304347826086957 25.2 25 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 9.25095982646018e-05 0.000615145599675366 1.49668958492488 0.303030303030303 25.2 25 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0402381383338388 0.097711383701455 1.49668958492488 0.303030303030303 25.2 25 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0402381383338388 0.097711383701455 1.49668958492488 0.303030303030303 25.2 25 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000370250250847683 0.00198817398851416 1.49531647521394 0.302752293577982 25.2 25 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00270200723781737 0.0105630667566322 1.49472025652366 0.302631578947368 25.2 25 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.00270200723781737 0.0105630667566322 1.49472025652366 0.302631578947368 25.2 25 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0213464820203939 0.0594443129452456 1.49320891147157 0.302325581395349 25.2 25 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0019472105658654 0.00803153807312018 1.48767338260605 0.301204819277108 25.2 25 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.00011101498967001 0.000714815974210063 1.48543627977507 0.300751879699248 25.2 25 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.000444484785667953 0.00225089626336476 1.48172268907563 0.3 25.2 25 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00452801302037143 0.016699500621032 1.48172268907563 0.3 25.2 25 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.0150652958800494 0.0450537976506183 1.48172268907563 0.3 25.2 25 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0280386410560469 0.0745000743796959 1.48172268907563 0.3 25.2 25 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0533908335166041 0.123939895748985 1.48172268907563 0.3 25.2 25 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.105804693139852 0.208531964457076 1.48172268907563 0.3 25.2 25 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.105804693139852 0.208531964457076 1.48172268907563 0.3 25.2 25 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.000571271462305902 0.00278397017418253 1.47710673054268 0.299065420560748 25.2 25 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.95265903191976e-24 6.94658450605454e-22 1.46342981637099 0.296296296296296 25.2 25 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0711121907798114 0.158236846077343 1.46342981637099 0.296296296296296 25.2 25 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0711121907798114 0.158236846077343 1.46342981637099 0.296296296296296 25.2 25 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.144204777675966 0.264778578881162 1.45266930301532 0.294117647058824 25.2 25 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.144204777675966 0.264778578881162 1.45266930301532 0.294117647058824 25.2 25 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.144204777675966 0.264778578881162 1.45266930301532 0.294117647058824 25.2 25 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.144204777675966 0.264778578881162 1.45266930301532 0.294117647058824 25.2 25 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00908249612198596 0.0293070112961134 1.44372979961215 0.292307692307692 25.2 25 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.00647116694634413 0.0223506567103099 1.4405637254902 0.291666666666667 25.2 25 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0235976514601098 0.0640829351674356 1.4405637254902 0.291666666666667 25.2 25 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0951508279044394 0.193982275226386 1.4405637254902 0.291666666666667 25.2 25 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00462453066444996 0.0169605854008049 1.43795872779492 0.291139240506329 25.2 25 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0644050244362858 0.145243026581354 1.43392518297642 0.290322580645161 25.2 25 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0644050244362858 0.145243026581354 1.43392518297642 0.290322580645161 25.2 25 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0442920731191638 0.107007843885518 1.4297324192835 0.289473684210526 25.2 25 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00425946091589897 0.0159926461301431 1.42816644730181 0.289156626506024 25.2 25 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.95714026202435e-07 5.41443326236602e-06 1.42644783545187 0.288808664259928 25.2 25 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0215829894607317 0.0595748982498107 1.42473335488041 0.288461538461538 25.2 25 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0215829894607317 0.0595748982498107 1.42473335488041 0.288461538461538 25.2 25 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0215829894607317 0.0595748982498107 1.42473335488041 0.288461538461538 25.2 25 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0582435568252917 0.134984660199332 1.41116446578631 0.285714285714286 25.2 25 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0280618691971307 0.0745000743796959 1.41116446578631 0.285714285714286 25.2 25 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0854670291889436 0.181372635341153 1.41116446578631 0.285714285714286 25.2 25 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0854670291889436 0.181372635341153 1.41116446578631 0.285714285714286 25.2 25 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.128035969848133 0.247702877548625 1.41116446578631 0.285714285714286 25.2 25 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.128035969848133 0.247702877548625 1.41116446578631 0.285714285714286 25.2 25 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00645257254779697 0.022340658723881 1.4024535740222 0.283950617283951 25.2 25 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0365126002922282 0.0919600534793642 1.39582572159299 0.282608695652174 25.2 25 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0365126002922282 0.0919600534793642 1.39582572159299 0.282608695652174 25.2 25 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.79590244339924e-07 2.74792384619045e-06 1.39384956436562 0.282208588957055 25.2 25 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0082778866507609 0.027369906218374 1.39307261366085 0.282051282051282 25.2 25 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 4.53039586959175e-06 4.23114805224651e-05 1.39156495931706 0.281746031746032 25.2 25 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 4.53039586959175e-06 4.23114805224651e-05 1.39156495931706 0.281746031746032 25.2 25 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 4.53039586959175e-06 4.23114805224651e-05 1.39156495931706 0.281746031746032 25.2 25 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.011630205757766 0.0362933833186426 1.39128890993017 0.28169014084507 25.2 25 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00756815602717451 0.0252804836306792 1.38535048165608 0.280487804878049 25.2 25 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.113839197482999 0.22313109919877 1.38294117647059 0.28 25.2 25 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.113839197482999 0.22313109919877 1.38294117647059 0.28 25.2 25 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00494991576806089 0.0176534589923575 1.38081684286618 0.279569892473118 25.2 25 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0475449488582593 0.113899768056066 1.37834668751221 0.27906976744186 25.2 25 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0211294337627404 0.0589552632242736 1.37646370023419 0.278688524590164 25.2 25 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.17351566467236 0.307487908877669 1.37196545284781 0.277777777777778 25.2 25 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.17351566467236 0.307487908877669 1.37196545284781 0.277777777777778 25.2 25 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.55642931989077e-11 1.1466216588564e-09 1.3666794213307 0.276707530647986 25.2 25 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.101385981451955 0.200656817254703 1.36250362213851 0.275862068965517 25.2 25 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.101385981451955 0.200656817254703 1.36250362213851 0.275862068965517 25.2 25 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.101385981451955 0.200656817254703 1.36250362213851 0.275862068965517 25.2 25 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0619600563061997 0.143364488006052 1.35824579831933 0.275 25.2 25 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.0387972326771743 0.0954707814476457 1.3558246828143 0.274509803921569 25.2 25 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.0102721361230172 0.032410753221848 1.35236594637855 0.273809523809524 25.2 25 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.0102721361230172 0.032410753221848 1.35236594637855 0.273809523809524 25.2 25 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 9.76053290501152e-12 3.65506271679773e-10 1.35190872616543 0.273716951788491 25.2 25 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0904451255420439 0.185987591974463 1.34702062643239 0.272727272727273 25.2 25 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0904451255420439 0.185987591974463 1.34702062643239 0.272727272727273 25.2 25 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0904451255420439 0.185987591974463 1.34702062643239 0.272727272727273 25.2 25 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0904451255420439 0.185987591974463 1.34702062643239 0.272727272727273 25.2 25 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00934843637294813 0.0298939886712476 1.34702062643239 0.272727272727273 25.2 25 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.152303662781301 0.279288804301277 1.34702062643239 0.272727272727273 25.2 25 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0202718507175049 0.0566735630078771 1.340606242497 0.271428571428571 25.2 25 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 2.63409144831593e-05 0.000196246708426889 1.3364557587741 0.270588235294118 25.2 25 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0451393222832322 0.108685711690422 1.32975113122172 0.269230769230769 25.2 25 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.134290813502486 0.25017255967428 1.32975113122172 0.269230769230769 25.2 25 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.134290813502486 0.25017255967428 1.32975113122172 0.269230769230769 25.2 25 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.134290813502486 0.25017255967428 1.32975113122172 0.269230769230769 25.2 25 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.134290813502486 0.25017255967428 1.32975113122172 0.269230769230769 25.2 25 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 7.97323808115416e-24 2.26918355789647e-21 1.3200628217717 0.267269205939316 25.2 25 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.0191897533571459 0.0548333715405995 1.31291883842144 0.265822784810127 25.2 25 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.0298440489128321 0.0777803692361907 1.30740237271379 0.264705882352941 25.2 25 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.10547815613875 0.208465855813112 1.30740237271379 0.264705882352941 25.2 25 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.204857944259208 0.341750122720812 1.29975674480318 0.263157894736842 25.2 25 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.178423137146442 0.314617254224767 1.28845451223968 0.260869565217391 25.2 25 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.178423137146442 0.314617254224767 1.28845451223968 0.260869565217391 25.2 25 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.00592705579219674 0.0206720597850391 1.28338185667968 0.259842519685039 25.2 25 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.156403331455423 0.284970474598036 1.28050108932462 0.259259259259259 25.2 25 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.156403331455423 0.284970474598036 1.28050108932462 0.259259259259259 25.2 25 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.156403331455423 0.284970474598036 1.28050108932462 0.259259259259259 25.2 25 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.156403331455423 0.284970474598036 1.28050108932462 0.259259259259259 25.2 25 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0433960879741671 0.105200397252538 1.27218614718615 0.257575757575758 25.2 25 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00567845773539064 0.0198585839124699 1.26104058644734 0.25531914893617 25.2 25 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.0856610468822815 0.181372635341153 1.26104058644734 0.25531914893617 25.2 25 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0684167316572634 0.15331812464297 1.2572192513369 0.254545454545455 25.2 25 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0684167316572634 0.15331812464297 1.2572192513369 0.254545454545455 25.2 25 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0175352585561874 0.0510279609927497 1.24630880389539 0.252336448598131 25.2 25 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00409163975399689 0.0155264089865002 1.23476890756303 0.25 25.2 25 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.158112211897307 0.287348247164583 1.23476890756303 0.25 25.2 25 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.180048765544249 0.315136943868701 1.23476890756303 0.25 25.2 25 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.237875694632327 0.385971623103536 1.23476890756303 0.25 25.2 25 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.237875694632327 0.385971623103536 1.23476890756303 0.25 25.2 25 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00109512065717187 0.00488513070581684 1.22946947019151 0.248927038626609 25.2 25 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00257262784057305 0.0101128436937443 1.22850104508809 0.248730964467005 25.2 25 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00611582041663099 0.0212782700559068 1.22709953546636 0.248447204968944 25.2 25 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00682779371254775 0.0234119288023023 1.21952484697583 0.246913580246914 25.2 25 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0783910128195244 0.168760077522214 1.21452679432429 0.245901639344262 25.2 25 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00838600078089323 0.027369906218374 1.21147138100523 0.245283018867925 25.2 25 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00838600078089323 0.027369906218374 1.21147138100523 0.245283018867925 25.2 25 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.139929832525994 0.258262194143307 1.20465259274441 0.24390243902439 25.2 25 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.139929832525994 0.258262194143307 1.20465259274441 0.24390243902439 25.2 25 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.179765679530992 0.315136943868701 1.1973516679399 0.242424242424242 25.2 25 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0634926081080769 0.144629784570031 1.18787894904797 0.240506329113924 25.2 25 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.037681568269208 0.0932219286905725 1.18727779573368 0.240384615384615 25.2 25 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.00712858551285916 0.0240143916488562 1.18332020308123 0.239583333333333 25.2 25 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0154186979931591 0.0459012703854925 1.17900515044728 0.238709677419355 25.2 25 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.157506205818145 0.286612955088517 1.17597038815526 0.238095238095238 25.2 25 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.0876910562998687 0.181372635341153 1.16617063492063 0.236111111111111 25.2 25 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0251974702043581 0.0682971430491457 1.16421068427371 0.235714285714286 25.2 25 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.078304335671663 0.168760077522214 1.15854860462704 0.234567901234568 25.2 25 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.109371320664204 0.214966007327572 1.15759585084034 0.234375 25.2 25 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.156032010092121 0.284970474598036 1.15595387091007 0.234042553191489 25.2 25 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.231324506898429 0.377494006096863 1.15245098039216 0.233333333333333 25.2 25 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.231324506898429 0.377494006096863 1.15245098039216 0.233333333333333 25.2 25 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.030454218898973 0.0792255091284068 1.14781335069239 0.232394366197183 25.2 25 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.199383592032029 0.333269748940614 1.13978668390433 0.230769230769231 25.2 25 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.199383592032029 0.333269748940614 1.13978668390433 0.230769230769231 25.2 25 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.265656066493834 0.423173161177788 1.13978668390433 0.230769230769231 25.2 25 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.265656066493834 0.423173161177788 1.13978668390433 0.230769230769231 25.2 25 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.226562574495158 0.375441597668849 1.12893157262905 0.228571428571429 25.2 25 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0443929812892104 0.107069851482282 1.12581870983688 0.227941176470588 25.2 25 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.307464416229178 0.464404357551244 1.12251718869366 0.227272727272727 25.2 25 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.307464416229178 0.464404357551244 1.12251718869366 0.227272727272727 25.2 25 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.048425776535824 0.115814924387357 1.11760105502055 0.226277372262774 25.2 25 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.258610585725203 0.417236806674563 1.11527514231499 0.225806451612903 25.2 25 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.258610585725203 0.417236806674563 1.11527514231499 0.225806451612903 25.2 25 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.258610585725203 0.417236806674563 1.11527514231499 0.225806451612903 25.2 25 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.191712904186207 0.330675712311481 1.10877208026068 0.224489795918367 25.2 25 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.216143652693635 0.359313572176451 1.09757236227824 0.222222222222222 25.2 25 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.187599986273576 0.323974248139925 1.09757236227824 0.222222222222222 25.2 25 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.251449935586074 0.40706855328667 1.09757236227824 0.222222222222222 25.2 25 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.296871133647666 0.457194397381633 1.09757236227824 0.222222222222222 25.2 25 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.296871133647666 0.457194397381633 1.09757236227824 0.222222222222222 25.2 25 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0778102310659287 0.16801814689957 1.09307411489186 0.221311475409836 25.2 25 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0491112311674403 0.117091559382274 1.09083878950353 0.220858895705521 25.2 25 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.108465770699386 0.213481039702941 1.08659663865546 0.22 25.2 25 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.244355618298036 0.396034219633377 1.08418733346997 0.219512195121951 25.2 25 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0739669457611222 0.162430499719255 1.0815494080844 0.218978102189781 25.2 25 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.286750130397014 0.44304607552112 1.08042279411765 0.21875 25.2 25 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.0022798469401609 0.00916503506642244 1.07761650114591 0.218181818181818 25.2 25 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.205519844574174 0.342452855771721 1.07761650114591 0.218181818181818 25.2 25 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.23741627561077 0.385971623103536 1.07371209353307 0.217391304347826 25.2 25 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.23741627561077 0.385971623103536 1.07371209353307 0.217391304347826 25.2 25 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.343309215974382 0.501055399314405 1.07371209353307 0.217391304347826 25.2 25 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0273661060900512 0.0737537291025432 1.07112483547636 0.216867469879518 25.2 25 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.277144428051627 0.431527037277538 1.06790824437883 0.216216216216216 25.2 25 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.166897770672575 0.299499469402195 1.0628390596745 0.215189873417722 25.2 25 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.328731779494053 0.486862039745289 1.05837334933974 0.214285714285714 25.2 25 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.315553636399405 0.473164198731668 1.04768270944742 0.212121212121212 25.2 25 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.315553636399405 0.473164198731668 1.04768270944742 0.212121212121212 25.2 25 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.315553636399405 0.473164198731668 1.04768270944742 0.212121212121212 25.2 25 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.175967908455169 0.311058799666714 1.04592189817103 0.211764705882353 25.2 25 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.175967908455169 0.311058799666714 1.04592189817103 0.211764705882353 25.2 25 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.171492875863826 0.304662125286173 1.04269374416433 0.211111111111111 25.2 25 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0766900641396631 0.16585100497073 1.04121053826936 0.210810810810811 25.2 25 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.292376318310834 0.451248916438521 1.03376001563416 0.209302325581395 25.2 25 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.282038240999552 0.436239583633003 1.02897408963585 0.208333333333333 25.2 25 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.379395700820156 0.545884815234663 1.02897408963585 0.208333333333333 25.2 25 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.379395700820156 0.545884815234663 1.02897408963585 0.208333333333333 25.2 25 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 2.16148057119944e-06 2.29536332299761e-05 1.01913609346177 0.206341463414634 25.2 25 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.344831851271322 0.501733869487823 1.01686851211073 0.205882352941176 25.2 25 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.344831851271322 0.501733869487823 1.01686851211073 0.205882352941176 25.2 25 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.344831851271322 0.501733869487823 1.01686851211073 0.205882352941176 25.2 25 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.342514894462816 0.500409337598139 0.98781512605042 0.2 25.2 25 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.374399170465363 0.543088704966576 0.98781512605042 0.2 25.2 25 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.328794392266495 0.486862039745289 0.98781512605042 0.2 25.2 25 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.393405536648636 0.565470786516171 0.98781512605042 0.2 25.2 25 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.415409373997391 0.581034835222482 0.98781512605042 0.2 25.2 25 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.415409373997391 0.581034835222482 0.98781512605042 0.2 25.2 25 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.415409373997391 0.581034835222482 0.98781512605042 0.2 25.2 25 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.415409373997391 0.581034835222482 0.98781512605042 0.2 25.2 25 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.415409373997391 0.581034835222482 0.98781512605042 0.2 25.2 25 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.415409373997391 0.581034835222482 0.98781512605042 0.2 25.2 25 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.205847782077653 0.342598121516374 0.963722074195532 0.195121951219512 25.2 25 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.42575632487026 0.581034835222482 0.955950121984278 0.193548387096774 25.2 25 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.451064923402999 0.611300367621398 0.949822236586943 0.192307692307692 25.2 25 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.313743732569568 0.471942210831391 0.945780439835509 0.191489361702128 25.2 25 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.412589755452106 0.581034835222482 0.94077631052421 0.19047619047619 25.2 25 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.43369407223976 0.58888040534082 0.934419713831478 0.189189189189189 25.2 25 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.40120058190555 0.566377408781348 0.931901062311717 0.188679245283019 25.2 25 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.40120058190555 0.566377408781348 0.931901062311717 0.188679245283019 25.2 25 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.492126032718754 0.655093867688294 0.886500754147813 0.179487179487179 25.2 25 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.520321398493375 0.670634740929785 0.881977791116446 0.178571428571429 25.2 25 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.520321398493375 0.670634740929785 0.881977791116446 0.178571428571429 25.2 25 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.500826698672593 0.666052703001027 0.858969674826452 0.173913043478261 25.2 25 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.455067421660537 0.616137907728777 0.85223265776899 0.172549019607843 25.2 25 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.550658802466583 0.70657121362484 0.846698679471789 0.171428571428571 25.2 25 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.542203215741107 0.696349436822739 0.831844316674038 0.168421052631579 25.2 25 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.585537587811018 0.742620309674758 0.823179271708683 0.166666666666667 25.2 25 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.585537587811018 0.742620309674758 0.823179271708683 0.166666666666667 25.2 25 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.590066552006724 0.74769786598893 0.809684529549525 0.163934426229508 25.2 25 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.68249152882492 0.832920622228012 0.763774581997748 0.154639175257732 25.2 25 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.713377189432363 0.866896447960933 0.74834479246244 0.151515151515152 25.2 25 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.699874809135797 0.853403473350676 0.726334651507662 0.147058823529412 25.2 25 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.719810107072388 0.873967391095571 0.720281862745098 0.145833333333333 25.2 25 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.932828902375429 1 0.700126700164602 0.141752577319588 25.2 25 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.753600170296543 0.907252996896769 0.689173343756107 0.13953488372093 25.2 25 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.942305761149928 1 0.670303121248499 0.135714285714286 25.2 25 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.913027722859136 1 0.66385425137797 0.134408602150538 25.2 25 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.790306399033521 0.941092891903515 0.649878372401592 0.131578947368421 25.2 25 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.953932042957714 1 0.637300081322852 0.129032258064516 25.2 25 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.927812337356303 1 0.556515563972068 0.112676056338028 25.2 25 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99086516620129 1 0.533195664629488 0.107954545454545 25.2 25 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999797446 1 0.522521855089643 0.105793450881612 25.2 25 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999999999999 1 0.428708192137615 0.0867992766726944 25.2 25 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.99873586183472 1 0.365857454092748 0.0740740740740741 25.2 25 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999665612678184 1 0.274393090569561 0.0555555555555556 25.2 25 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.000261917479248152 0.00109943531849593 4.20306748466258 1 25.3 25 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.000261917479248152 0.00109943531849593 4.20306748466258 1 25.3 25 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 1.38479951139153e-05 8.57749681665482e-05 3.73605998636673 0.888888888888889 25.3 25 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 1.38479951139153e-05 8.57749681665482e-05 3.73605998636673 0.888888888888889 25.3 25 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 3.07690559941916e-06 2.25692611751209e-05 3.50255623721881 0.833333333333333 25.3 25 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 3.07690559941916e-06 2.25692611751209e-05 3.50255623721881 0.833333333333333 25.3 25 3 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.00131996556458622 0.00434794212594024 3.50255623721881 0.833333333333333 25.3 25 3 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.00131996556458622 0.00434794212594024 3.50255623721881 0.833333333333333 25.3 25 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 5.74528805671301e-05 0.000294084349090022 3.36245398773006 0.8 25.3 25 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 5.74528805671301e-05 0.000294084349090022 3.36245398773006 0.8 25.3 25 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 1.10147220070371e-05 7.02867686816761e-05 3.23312883435583 0.769230769230769 25.3 25 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.57226298522586e-08 2.79414521219572e-07 3.20233713117149 0.761904761904762 25.3 25 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 2.10576889233482e-06 1.59388783712364e-05 3.15230061349693 0.75 25.3 25 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.000983820278516611 0.00335725720942239 3.15230061349693 0.75 25.3 25 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.000983820278516611 0.00335725720942239 3.15230061349693 0.75 25.3 25 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.000983820278516611 0.00335725720942239 3.15230061349693 0.75 25.3 25 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.000983820278516611 0.00335725720942239 3.15230061349693 0.75 25.3 25 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.000983820278516611 0.00335725720942239 3.15230061349693 0.75 25.3 25 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000983820278516611 0.00335725720942239 3.15230061349693 0.75 25.3 25 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.000983820278516611 0.00335725720942239 3.15230061349693 0.75 25.3 25 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 4.4420359756252e-05 0.000235858850496816 3.15230061349693 0.75 25.3 25 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 8.27918592223984e-06 5.47966584527781e-05 3.08224948875256 0.733333333333333 25.3 25 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.000174893177709804 0.000761079485874776 3.05677635248187 0.727272727272727 25.3 25 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.000174893177709804 0.000761079485874776 3.05677635248187 0.727272727272727 25.3 25 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000174893177709804 0.000761079485874776 3.05677635248187 0.727272727272727 25.3 25 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.000174893177709804 0.000761079485874776 3.05677635248187 0.727272727272727 25.3 25 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 3.18601217004021e-05 0.000171730883256334 3.00219106047327 0.714285714285714 25.3 25 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00388441733201227 0.011280665027456 3.00219106047327 0.714285714285714 25.3 25 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00388441733201227 0.011280665027456 3.00219106047327 0.714285714285714 25.3 25 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00388441733201227 0.011280665027456 3.00219106047327 0.714285714285714 25.3 25 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 2.94822430269827e-07 2.72423583294782e-06 3.00219106047327 0.714285714285714 25.3 25 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 5.89793795664076e-06 4.04407854334756e-05 2.96687116564417 0.705882352941177 25.3 25 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.000668979095413844 0.00249369452070254 2.9421472392638 0.7 25.3 25 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000668979095413844 0.00249369452070254 2.9421472392638 0.7 25.3 25 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.000668979095413844 0.00249369452070254 2.9421472392638 0.7 25.3 25 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 7.67484431252993e-11 1.30015517342025e-09 2.91879686434901 0.694444444444444 25.3 25 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 3.96205697600473e-08 4.20746796780204e-07 2.90981595092025 0.692307692307692 25.3 25 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000119583044691986 0.000552489196742517 2.90981595092025 0.692307692307692 25.3 25 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.45127534532267e-09 2.06516481639416e-08 2.88960889570552 0.6875 25.3 25 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 2.18607033880309e-05 0.000121041949109603 2.88960889570552 0.6875 25.3 25 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 2.18607033880309e-05 0.000121041949109603 2.88960889570552 0.6875 25.3 25 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 7.60823942894536e-07 6.29449110894724e-06 2.86572783045176 0.681818181818182 25.3 25 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 7.90219932567265e-05 0.000385096905494253 2.80204498977505 0.666666666666667 25.3 25 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.000435838813616909 0.00170853617569383 2.80204498977505 0.666666666666667 25.3 25 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000435838813616909 0.00170853617569383 2.80204498977505 0.666666666666667 25.3 25 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.000435838813616909 0.00170853617569383 2.80204498977505 0.666666666666667 25.3 25 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00246963934550755 0.00750918117234453 2.80204498977505 0.666666666666667 25.3 25 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00246963934550755 0.00750918117234453 2.80204498977505 0.666666666666667 25.3 25 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00246963934550755 0.00750918117234453 2.80204498977505 0.666666666666667 25.3 25 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00246963934550755 0.00750918117234453 2.80204498977505 0.666666666666667 25.3 25 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00246963934550755 0.00750918117234453 2.80204498977505 0.666666666666667 25.3 25 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00246963934550755 0.00750918117234453 2.80204498977505 0.666666666666667 25.3 25 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 9.53937332545553e-06 6.22684781748772e-05 2.73199386503068 0.65 25.3 25 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 5.11257733455793e-05 0.000264552638075488 2.71963190184049 0.647058823529412 25.3 25 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 5.11257733455793e-05 0.000264552638075488 2.71963190184049 0.647058823529412 25.3 25 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 5.11257733455793e-05 0.000264552638075488 2.71963190184049 0.647058823529412 25.3 25 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000277484306076836 0.00115119582375317 2.70197195442594 0.642857142857143 25.3 25 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.16983124516459e-06 9.35207787566976e-06 2.68996319018405 0.64 25.3 25 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 6.15728405107045e-06 4.15251905434752e-05 2.67467930842164 0.636363636363636 25.3 25 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00153362945139592 0.00497494522714901 2.67467930842164 0.636363636363636 25.3 25 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00153362945139592 0.00497494522714901 2.67467930842164 0.636363636363636 25.3 25 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 3.26206109837871e-05 0.000175166526150675 2.65456893768163 0.631578947368421 25.3 25 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00871874575450503 0.0232336614394394 2.62691717791411 0.625 25.3 25 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00871874575450503 0.0232336614394394 2.62691717791411 0.625 25.3 25 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00871874575450503 0.0232336614394394 2.62691717791411 0.625 25.3 25 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00871874575450503 0.0232336614394394 2.62691717791411 0.625 25.3 25 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00871874575450503 0.0232336614394394 2.62691717791411 0.625 25.3 25 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00871874575450503 0.0232336614394394 2.62691717791411 0.625 25.3 25 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00871874575450503 0.0232336614394394 2.62691717791411 0.625 25.3 25 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 2.49646088843875e-06 1.8796104996023e-05 2.58650306748466 0.615384615384615 25.3 25 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00010855459998419 0.000503170018819227 2.56854124062713 0.611111111111111 25.3 25 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00010855459998419 0.000503170018819227 2.56854124062713 0.611111111111111 25.3 25 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00010855459998419 0.000503170018819227 2.56854124062713 0.611111111111111 25.3 25 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.78090710742114e-09 5.91585288161764e-08 2.56284602723328 0.609756097560976 25.3 25 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.78090710742114e-09 5.91585288161764e-08 2.56284602723328 0.609756097560976 25.3 25 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 1.29408231924198e-05 8.11224290872833e-05 2.55838890370766 0.608695652173913 25.3 25 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.29408231924198e-05 8.11224290872833e-05 2.55838890370766 0.608695652173913 25.3 25 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.29408231924198e-05 8.11224290872833e-05 2.55838890370766 0.608695652173913 25.3 25 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.57480815107392e-06 1.21176127042846e-05 2.55186240140228 0.607142857142857 25.3 25 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 6.72424674712843e-05 0.000335740460391711 2.52184049079755 0.6 25.3 25 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 6.72424674712843e-05 0.000335740460391711 2.52184049079755 0.6 25.3 25 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 6.72424674712843e-05 0.000335740460391711 2.52184049079755 0.6 25.3 25 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 6.72424674712843e-05 0.000335740460391711 2.52184049079755 0.6 25.3 25 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00517062972064809 0.0148044388178717 2.52184049079755 0.6 25.3 25 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00517062972064809 0.0148044388178717 2.52184049079755 0.6 25.3 25 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00517062972064809 0.0148044388178717 2.52184049079755 0.6 25.3 25 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.00517062972064809 0.0148044388178717 2.52184049079755 0.6 25.3 25 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 9.89048640341089e-07 7.9966830409396e-06 2.52184049079755 0.6 25.3 25 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000575177775307 0.00220614009235003 2.52184049079755 0.6 25.3 25 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000575177775307 0.00220614009235003 2.52184049079755 0.6 25.3 25 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000575177775307 0.00220614009235003 2.52184049079755 0.6 25.3 25 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000575177775307 0.00220614009235003 2.52184049079755 0.6 25.3 25 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000575177775307 0.00220614009235003 2.52184049079755 0.6 25.3 25 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000575177775307 0.00220614009235003 2.52184049079755 0.6 25.3 25 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 7.69792660508854e-08 7.76890039648298e-07 2.49912120709667 0.594594594594595 25.3 25 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 5.03049079538992e-06 3.56138726459694e-05 2.49070665757782 0.592592592592593 25.3 25 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 5.03049079538992e-06 3.56138726459694e-05 2.49070665757782 0.592592592592593 25.3 25 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 5.03049079538992e-06 3.56138726459694e-05 2.49070665757782 0.592592592592593 25.3 25 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000350240861645943 0.00141775479297578 2.47239263803681 0.588235294117647 25.3 25 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.42145517557101e-11 4.72017906142129e-10 2.45178936605317 0.583333333333333 25.3 25 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.42145517557101e-11 4.72017906142129e-10 2.45178936605317 0.583333333333333 25.3 25 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.42145517557101e-11 4.72017906142129e-10 2.45178936605317 0.583333333333333 25.3 25 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.42145517557101e-11 4.72017906142129e-10 2.45178936605317 0.583333333333333 25.3 25 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.42145517557101e-11 4.72017906142129e-10 2.45178936605317 0.583333333333333 25.3 25 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.42145517557101e-11 4.72017906142129e-10 2.45178936605317 0.583333333333333 25.3 25 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.42145517557101e-11 4.72017906142129e-10 2.45178936605317 0.583333333333333 25.3 25 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.55487293305191e-05 0.000139830160912803 2.45178936605317 0.583333333333333 25.3 25 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00307053634428653 0.0091028608706661 2.45178936605317 0.583333333333333 25.3 25 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00307053634428653 0.0091028608706661 2.45178936605317 0.583333333333333 25.3 25 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00307053634428653 0.0091028608706661 2.45178936605317 0.583333333333333 25.3 25 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00307053634428653 0.0091028608706661 2.45178936605317 0.583333333333333 25.3 25 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00307053634428653 0.0091028608706661 2.45178936605317 0.583333333333333 25.3 25 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.22124106132583e-12 3.77788267449273e-11 2.43656086067396 0.579710144927536 25.3 25 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000212963834859744 0.000907327955106034 2.43335485954149 0.578947368421053 25.3 25 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000212963834859744 0.000907327955106034 2.43335485954149 0.578947368421053 25.3 25 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 9.50929130350493e-12 2.25528692081459e-10 2.42989838957055 0.578125 25.3 25 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 9.63806765447793e-06 6.25548737834352e-05 2.40175284837862 0.571428571428571 25.3 25 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00182766636099005 0.0057412124319842 2.40175284837862 0.571428571428571 25.3 25 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00182766636099005 0.0057412124319842 2.40175284837862 0.571428571428571 25.3 25 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00182766636099005 0.0057412124319842 2.40175284837862 0.571428571428571 25.3 25 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00182766636099005 0.0057412124319842 2.40175284837862 0.571428571428571 25.3 25 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000129411492452374 0.000589128150876511 2.40175284837862 0.571428571428571 25.3 25 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000129411492452374 0.000589128150876511 2.40175284837862 0.571428571428571 25.3 25 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.91123216455581e-06 4.04407854334756e-05 2.38173824130879 0.566666666666667 25.3 25 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00109060387393872 0.00365159838262306 2.3642254601227 0.5625 25.3 25 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00109060387393872 0.00365159838262306 2.3642254601227 0.5625 25.3 25 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00109060387393872 0.00365159838262306 2.3642254601227 0.5625 25.3 25 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00109060387393872 0.00365159838262306 2.3642254601227 0.5625 25.3 25 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 4.77775937390208e-05 0.000249954102539068 2.35371779141104 0.56 25.3 25 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 4.77775937390208e-05 0.000249954102539068 2.35371779141104 0.56 25.3 25 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.54777039272298e-08 6.75179512235131e-07 2.33503749147921 0.555555555555556 25.3 25 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.36004019626601e-06 1.06924707142902e-05 2.33503749147921 0.555555555555556 25.3 25 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0165301287657519 0.0399361175444226 2.33503749147921 0.555555555555556 25.3 25 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0165301287657519 0.0399361175444226 2.33503749147921 0.555555555555556 25.3 25 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0165301287657519 0.0399361175444226 2.33503749147921 0.555555555555556 25.3 25 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.90493668914265e-12 1.31692922804717e-10 2.32872657934008 0.554054054054054 25.3 25 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.90493668914265e-12 1.31692922804717e-10 2.32872657934008 0.554054054054054 25.3 25 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.02787234160923e-08 4.24567580897032e-07 2.32510116172823 0.553191489361702 25.3 25 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 3.03462020371243e-12 8.63652909976556e-11 2.32274782047142 0.552631578947368 25.3 25 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 6.06386648600359e-11 1.0523026840955e-09 2.32109696914202 0.552238805970149 25.3 25 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.47707817250805e-08 2.73246685230926e-07 2.31597596093652 0.551020408163265 25.3 25 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000391067728334527 0.00156757571104234 2.31168711656442 0.55 25.3 25 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 8.80850415050887e-12 2.12449176375833e-10 2.29767689161554 0.546666666666667 25.3 25 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 8.80850415050887e-12 2.12449176375833e-10 2.29767689161554 0.546666666666667 25.3 25 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 8.80850415050887e-12 2.12449176375833e-10 2.29767689161554 0.546666666666667 25.3 25 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 8.80850415050887e-12 2.12449176375833e-10 2.29767689161554 0.546666666666667 25.3 25 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 8.80850415050887e-12 2.12449176375833e-10 2.29767689161554 0.546666666666667 25.3 25 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000234905192793038 0.000991899374909474 2.29258226436141 0.545454545454545 25.3 25 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00953503004375069 0.0246249505485612 2.29258226436141 0.545454545454545 25.3 25 3 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.00953503004375069 0.0246249505485612 2.29258226436141 0.545454545454545 25.3 25 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00953503004375069 0.0246249505485612 2.29258226436141 0.545454545454545 25.3 25 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00953503004375069 0.0246249505485612 2.29258226436141 0.545454545454545 25.3 25 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00953503004375069 0.0246249505485612 2.29258226436141 0.545454545454545 25.3 25 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.04379709118016e-13 5.30472593124776e-12 2.28833674164962 0.544444444444444 25.3 25 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000141356091163654 0.000626634634660061 2.27666155419223 0.541666666666667 25.3 25 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.20642011941304e-10 1.1916056969311e-08 2.2683221345798 0.53968253968254 25.3 25 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 8.51997450034442e-05 0.000408212919662967 2.26319018404908 0.538461538461538 25.3 25 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 8.51997450034442e-05 0.000408212919662967 2.26319018404908 0.538461538461538 25.3 25 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00555400602807456 0.0156192699168974 2.26319018404908 0.538461538461538 25.3 25 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00555400602807456 0.0156192699168974 2.26319018404908 0.538461538461538 25.3 25 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00555400602807456 0.0156192699168974 2.26319018404908 0.538461538461538 25.3 25 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00325908188748497 0.00958197009481634 2.24163599182004 0.533333333333333 25.3 25 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 2.32797694788477e-09 3.15496304460955e-08 2.23711656441718 0.532258064516129 25.3 25 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.66604274962477e-11 3.76314100431118e-10 2.2345422070358 0.531645569620253 25.3 25 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.66604274962477e-11 3.76314100431118e-10 2.2345422070358 0.531645569620253 25.3 25 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.86353118777353e-12 1.0780009569023e-10 2.22515337423313 0.529411764705882 25.3 25 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 1.13934911704295e-05 7.23791872121481e-05 2.22515337423313 0.529411764705882 25.3 25 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00192351226276809 0.00596330708043352 2.22515337423313 0.529411764705882 25.3 25 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00192351226276809 0.00596330708043352 2.22515337423313 0.529411764705882 25.3 25 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00192351226276809 0.00596330708043352 2.22515337423313 0.529411764705882 25.3 25 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00114055408190468 0.0037767689724714 2.21214078140136 0.526315789473684 25.3 25 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.54790004165027e-06 1.20364030561111e-05 2.2016067776804 0.523809523809524 25.3 25 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000678889587804895 0.00251578094647491 2.2016067776804 0.523809523809524 25.3 25 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000678889587804895 0.00251578094647491 2.2016067776804 0.523809523809524 25.3 25 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 9.41510117601265e-07 7.69982124911839e-06 2.19705800334635 0.522727272727273 25.3 25 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000405390381108311 0.00161137014613722 2.19290477460656 0.521739130434783 25.3 25 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 5.59622240593508e-10 8.20971596252126e-09 2.19033094271148 0.52112676056338 25.3 25 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.48968137359234e-07 3.1629405061286e-06 2.18909764826176 0.520833333333333 25.3 25 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 3.48968137359234e-07 3.1629405061286e-06 2.18909764826176 0.520833333333333 25.3 25 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 7.87912116948308e-11 1.3037197004854e-09 2.181338821154 0.518987341772152 25.3 25 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 7.87912116948308e-11 1.3037197004854e-09 2.181338821154 0.518987341772152 25.3 25 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 4.82818664546875e-11 8.58813699562754e-10 2.1793683253806 0.518518518518518 25.3 25 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 4.82818664546875e-11 8.58813699562754e-10 2.1793683253806 0.518518518518518 25.3 25 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.81369390329854e-11 3.91043397635427e-10 2.17570552147239 0.517647058823529 25.3 25 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.81369390329854e-11 3.91043397635427e-10 2.17570552147239 0.517647058823529 25.3 25 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.81369390329854e-11 3.91043397635427e-10 2.17570552147239 0.517647058823529 25.3 25 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 8.76087177175161e-05 0.000415251153001044 2.17400042310133 0.517241379310345 25.3 25 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 8.76087177175161e-05 0.000415251153001044 2.17400042310133 0.517241379310345 25.3 25 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 8.76087177175161e-05 0.000415251153001044 2.17400042310133 0.517241379310345 25.3 25 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.56275049262609e-12 7.44243663470801e-11 2.16932515337423 0.516129032258065 25.3 25 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 6.71012494653436e-09 7.98371165990685e-08 2.16720667177914 0.515625 25.3 25 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 6.71012494653436e-09 7.98371165990685e-08 2.16720667177914 0.515625 25.3 25 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 1.92429246850671e-05 0.000107805833963978 2.16157756354075 0.514285714285714 25.3 25 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.31604461127967e-10 2.15256492166779e-09 2.15407208588957 0.5125 25.3 25 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 2.593967464108e-06 1.9325736656679e-05 2.15040662005992 0.511627906976744 25.3 25 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.57537480695196e-06 1.21176127042846e-05 2.14823449216087 0.511111111111111 25.3 25 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 9.81384073180534e-13 3.77788267449273e-11 2.14356441717791 0.51 25.3 25 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.3148970245337e-07 1.26425572021045e-06 2.13974344673731 0.509090909090909 25.3 25 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.3148970245337e-07 1.26425572021045e-06 2.13974344673731 0.509090909090909 25.3 25 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.3148970245337e-07 1.26425572021045e-06 2.13974344673731 0.509090909090909 25.3 25 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.82030703912474e-08 2.03960387139725e-07 2.13489142078099 0.507936507936508 25.3 25 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.82030703912474e-08 2.03960387139725e-07 2.13489142078099 0.507936507936508 25.3 25 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 6.78867962648439e-09 7.98371165990685e-08 2.13289991758996 0.507462686567164 25.3 25 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.60778216763227e-12 4.86781707349089e-11 2.10153374233129 0.5 25.3 25 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.16290841154334e-10 3.38221831827051e-09 2.10153374233129 0.5 25.3 25 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.16290841154334e-10 3.38221831827051e-09 2.10153374233129 0.5 25.3 25 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 6.76221734489192e-09 7.98371165990685e-08 2.10153374233129 0.5 25.3 25 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 3.5257370116119e-07 3.17204612136605e-06 2.10153374233129 0.5 25.3 25 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 2.57771655715894e-06 1.93057403201956e-05 2.10153374233129 0.5 25.3 25 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000400265848410569 0.00159545742937882 2.10153374233129 0.5 25.3 25 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000669424671052967 0.00249369452070254 2.10153374233129 0.5 25.3 25 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00112287398281675 0.00374203671556964 2.10153374233129 0.5 25.3 25 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00112287398281675 0.00374203671556964 2.10153374233129 0.5 25.3 25 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00189004043547483 0.00591104953775974 2.10153374233129 0.5 25.3 25 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00542755990103122 0.0153547072349253 2.10153374233129 0.5 25.3 25 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00542755990103122 0.0153547072349253 2.10153374233129 0.5 25.3 25 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00542755990103122 0.0153547072349253 2.10153374233129 0.5 25.3 25 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.00542755990103122 0.0153547072349253 2.10153374233129 0.5 25.3 25 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00542755990103122 0.0153547072349253 2.10153374233129 0.5 25.3 25 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00928034569515907 0.0244554294892803 2.10153374233129 0.5 25.3 25 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00928034569515907 0.0244554294892803 2.10153374233129 0.5 25.3 25 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00928034569515907 0.0244554294892803 2.10153374233129 0.5 25.3 25 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00928034569515907 0.0244554294892803 2.10153374233129 0.5 25.3 25 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0159995237432149 0.0388520858133017 2.10153374233129 0.5 25.3 25 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0159995237432149 0.0388520858133017 2.10153374233129 0.5 25.3 25 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0278896278108557 0.0624008496459868 2.10153374233129 0.5 25.3 25 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0278896278108557 0.0624008496459868 2.10153374233129 0.5 25.3 25 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0278896278108557 0.0624008496459868 2.10153374233129 0.5 25.3 25 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0278896278108557 0.0624008496459868 2.10153374233129 0.5 25.3 25 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0278896278108557 0.0624008496459868 2.10153374233129 0.5 25.3 25 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0278896278108557 0.0624008496459868 2.10153374233129 0.5 25.3 25 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 4.13208922851068e-09 5.24996693943812e-08 2.10153374233129 0.5 25.3 25 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00319467583681305 0.00941205738257758 2.10153374233129 0.5 25.3 25 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00319467583681305 0.00941205738257758 2.10153374233129 0.5 25.3 25 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00319467583681305 0.00941205738257758 2.10153374233129 0.5 25.3 25 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 8.44243993258935e-14 4.62061231695179e-12 2.08387379491674 0.495798319327731 25.3 25 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.48134162313857e-10 5.21468329444862e-09 2.07680981595092 0.494117647058824 25.3 25 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.28134915412294e-07 1.2574895491841e-06 2.06708236950618 0.491803278688525 25.3 25 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.28134915412294e-07 1.2574895491841e-06 2.06708236950618 0.491803278688525 25.3 25 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 2.10111414693001e-07 1.99325695405427e-06 2.06591452635957 0.491525423728814 25.3 25 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 5.657618427723e-07 4.73575942508814e-06 2.06332403792526 0.490909090909091 25.3 25 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 5.657618427723e-07 4.73575942508814e-06 2.06332403792526 0.490909090909091 25.3 25 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 5.657618427723e-07 4.73575942508814e-06 2.06332403792526 0.490909090909091 25.3 25 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.52672168327621e-06 1.19369503038574e-05 2.06032719836401 0.490196078431373 25.3 25 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.84888361657009e-05 0.000106805938422542 2.05027682178662 0.48780487804878 25.3 25 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.84888361657009e-05 0.000106805938422542 2.05027682178662 0.48780487804878 25.3 25 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.84888361657009e-05 0.000106805938422542 2.05027682178662 0.48780487804878 25.3 25 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 1.84888361657009e-05 0.000106805938422542 2.05027682178662 0.48780487804878 25.3 25 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.84888361657009e-05 0.000106805938422542 2.05027682178662 0.48780487804878 25.3 25 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.84888361657009e-05 0.000106805938422542 2.05027682178662 0.48780487804878 25.3 25 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.84888361657009e-05 0.000106805938422542 2.05027682178662 0.48780487804878 25.3 25 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.72475482236856e-08 1.96346088978437e-07 2.04315780504431 0.486111111111111 25.3 25 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 6.54612701544594e-12 1.72502569314436e-10 2.04261223553695 0.485981308411215 25.3 25 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 8.3521251340186e-05 0.00040501556621242 2.04148992112182 0.485714285714286 25.3 25 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000138425514173935 0.000615560958342218 2.03785090165458 0.484848484848485 25.3 25 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000138425514173935 0.000615560958342218 2.03785090165458 0.484848484848485 25.3 25 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.02637608029951e-07 1.93525715588336e-06 2.03374233128834 0.483870967741935 25.3 25 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 5.44268589384071e-07 4.63768983648823e-06 2.02906706156124 0.482758620689655 25.3 25 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 8.9257185524533e-07 7.34179046250928e-06 2.02647896581946 0.482142857142857 25.3 25 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000636667665836627 0.00239676742985587 2.02369915928198 0.481481481481481 25.3 25 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000636667665836627 0.00239676742985587 2.02369915928198 0.481481481481481 25.3 25 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000636667665836627 0.00239676742985587 2.02369915928198 0.481481481481481 25.3 25 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.98886930041472e-13 9.75917591203499e-12 2.01879619342061 0.480314960629921 25.3 25 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.70134151406939e-08 2.91212801100056e-07 2.01516934196151 0.479452054794521 25.3 25 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 4.41486018203927e-08 4.6193720875308e-07 2.01273654195109 0.47887323943662 25.3 25 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.06729990496643e-05 6.84129623769024e-05 2.01016271005602 0.478260869565217 25.3 25 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00178056728438283 0.00564308963402397 2.01016271005602 0.478260869565217 25.3 25 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00178056728438283 0.00564308963402397 2.01016271005602 0.478260869565217 25.3 25 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 8.58322552284079e-16 6.10696495950122e-14 2.00662576687117 0.47741935483871 25.3 25 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00299108666062931 0.00899855458366915 2.00146070698218 0.476190476190476 25.3 25 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 5.89539702191293e-09 7.17021364289068e-08 1.99901990124196 0.475609756097561 25.3 25 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 4.7694540284198e-05 0.000249954102539068 1.99645705521472 0.475 25.3 25 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.7694540284198e-05 0.000249954102539068 1.99645705521472 0.475 25.3 25 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.5606078849202e-08 2.79414521219572e-07 1.99092670326122 0.473684210526316 25.3 25 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.10925944042229e-16 9.28515402188779e-15 1.98961774421897 0.473372781065089 25.3 25 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.46457738169037e-11 4.73931569479108e-10 1.98690462911322 0.472727272727273 25.3 25 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.82179655648153e-08 6.98375287760663e-07 1.98478186775733 0.472222222222222 25.3 25 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000129997357255955 0.000589128150876511 1.98478186775733 0.472222222222222 25.3 25 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000129997357255955 0.000589128150876511 1.98478186775733 0.472222222222222 25.3 25 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000129997357255955 0.000589128150876511 1.98478186775733 0.472222222222222 25.3 25 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 3.72097970005646e-06 2.70150720060221e-05 1.98257900219933 0.471698113207547 25.3 25 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.98126464305831e-20 5.15030871551998e-18 1.98144609991236 0.471428571428571 25.3 25 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 3.41379801024815e-09 4.41621324416646e-08 1.98075594104788 0.471264367816092 25.3 25 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 3.41379801024815e-09 4.41621324416646e-08 1.98075594104788 0.471264367816092 25.3 25 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.7021095205431e-16 1.34561213762935e-14 1.97791411042945 0.470588235294118 25.3 25 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000214981215820112 0.000910471042000059 1.97791411042945 0.470588235294118 25.3 25 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000214981215820112 0.000910471042000059 1.97791411042945 0.470588235294118 25.3 25 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00854226891282067 0.0230657469885082 1.97791411042945 0.470588235294118 25.3 25 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00854226891282067 0.0230657469885082 1.97791411042945 0.470588235294118 25.3 25 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00854226891282067 0.0230657469885082 1.97791411042945 0.470588235294118 25.3 25 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.10156121378185e-06 4.13453409867218e-05 1.97791411042945 0.470588235294118 25.3 25 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.10156121378185e-06 4.13453409867218e-05 1.97791411042945 0.470588235294118 25.3 25 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 7.29668821831579e-13 3.34941526924625e-11 1.97220858895706 0.469230769230769 25.3 25 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.64304515110676e-05 0.00010077815732866 1.96739329069312 0.468085106382979 25.3 25 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.29588903716163e-06 1.02447227771167e-05 1.96143149284254 0.466666666666667 25.3 25 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000590317749353193 0.00225207012688899 1.96143149284254 0.466666666666667 25.3 25 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0145489515268739 0.035989168375534 1.96143149284254 0.466666666666667 25.3 25 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0145489515268739 0.035989168375534 1.96143149284254 0.466666666666667 25.3 25 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0145489515268739 0.035989168375534 1.96143149284254 0.466666666666667 25.3 25 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.8003417849651e-15 1.21994588571683e-13 1.95971244683654 0.466257668711656 25.3 25 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 6.84090900586658e-13 3.24487117178272e-11 1.95932469209834 0.466165413533835 25.3 25 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 3.46417512555202e-06 2.52795959162078e-05 1.95142418930762 0.464285714285714 25.3 25 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000980505834486936 0.00335725720942239 1.95142418930762 0.464285714285714 25.3 25 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000980505834486936 0.00335725720942239 1.95142418930762 0.464285714285714 25.3 25 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000980505834486936 0.00335725720942239 1.95142418930762 0.464285714285714 25.3 25 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.76746057056269e-07 2.59085288941494e-06 1.94924868853917 0.463768115942029 25.3 25 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.76746057056269e-07 2.59085288941494e-06 1.94924868853917 0.463768115942029 25.3 25 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 7.29176483865361e-05 0.000360284075187642 1.94776298069729 0.463414634146341 25.3 25 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 5.66624299355515e-06 3.91410863098494e-05 1.94586457623267 0.462962962962963 25.3 25 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.51213222276088e-07 3.86793021264381e-06 1.94470286603791 0.462686567164179 25.3 25 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.15972831514483e-15 4.63104245111414e-13 1.94391871165644 0.4625 25.3 25 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 9.27084602536766e-06 6.07945340741852e-05 1.9398773006135 0.461538461538462 25.3 25 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00163160401791095 0.0052174663314321 1.9398773006135 0.461538461538462 25.3 25 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00163160401791095 0.0052174663314321 1.9398773006135 0.461538461538462 25.3 25 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0249528246419067 0.0567218362067623 1.9398773006135 0.461538461538462 25.3 25 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0249528246419067 0.0567218362067623 1.9398773006135 0.461538461538462 25.3 25 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0249528246419067 0.0567218362067623 1.9398773006135 0.461538461538462 25.3 25 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0249528246419067 0.0567218362067623 1.9398773006135 0.461538461538462 25.3 25 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0249528246419067 0.0567218362067623 1.9398773006135 0.461538461538462 25.3 25 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0249528246419067 0.0567218362067623 1.9398773006135 0.461538461538462 25.3 25 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0249528246419067 0.0567218362067623 1.9398773006135 0.461538461538462 25.3 25 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0249528246419067 0.0567218362067623 1.9398773006135 0.461538461538462 25.3 25 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00019760083603623 0.000849504500542465 1.9311391145747 0.459459459459459 25.3 25 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.95692648797497e-06 1.49715397440236e-05 1.92927687820577 0.459016393442623 25.3 25 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00272076488027732 0.00820264496744623 1.92640593047035 0.458333333333333 25.3 25 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.06854585799644e-05 0.000216836732431796 1.91879167778074 0.456521739130435 25.3 25 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.80116313647088e-11 5.31474019093074e-10 1.91359170033418 0.455284552845528 25.3 25 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 6.66582812079343e-05 0.000335740460391711 1.91048522030117 0.454545454545455 25.3 25 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 6.66582812079343e-05 0.000335740460391711 1.91048522030117 0.454545454545455 25.3 25 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0431851259501098 0.0901062085439974 1.91048522030117 0.454545454545455 25.3 25 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0431851259501098 0.0901062085439974 1.91048522030117 0.454545454545455 25.3 25 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0431851259501098 0.0901062085439974 1.91048522030117 0.454545454545455 25.3 25 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0431851259501098 0.0901062085439974 1.91048522030117 0.454545454545455 25.3 25 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0431851259501098 0.0901062085439974 1.91048522030117 0.454545454545455 25.3 25 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0431851259501098 0.0901062085439974 1.91048522030117 0.454545454545455 25.3 25 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.38638388463149e-05 8.57749681665482e-05 1.90327584211136 0.452830188679245 25.3 25 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.12912361962958e-22 2.00842863841612e-20 1.9006518404908 0.452205882352941 25.3 25 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.80690040857954e-07 3.30318248866384e-06 1.90001680813514 0.452054794520548 25.3 25 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.80690040857954e-07 3.30318248866384e-06 1.90001680813514 0.452054794520548 25.3 25 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000887230945644574 0.00311735712506723 1.89815950920245 0.451612903225806 25.3 25 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00762339494593983 0.0209019094567869 1.89138036809816 0.45 25.3 25 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00762339494593983 0.0209019094567869 1.89138036809816 0.45 25.3 25 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 7.71721937636016e-06 5.13159026755164e-05 1.88413370002115 0.448275862068966 25.3 25 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000293854049486545 0.00121556486168417 1.88031966419115 0.447368421052632 25.3 25 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 8.89876940977158e-09 1.03794662869713e-07 1.86802999318337 0.444444444444444 25.3 25 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00242755309957042 0.00747707372443442 1.86802999318337 0.444444444444444 25.3 25 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0128203433736267 0.0323463628026079 1.86802999318337 0.444444444444444 25.3 25 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0128203433736267 0.0323463628026079 1.86802999318337 0.444444444444444 25.3 25 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.98483861963042e-09 6.11502185839146e-08 1.8590490797546 0.442307692307692 25.3 25 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.07989485779495e-07 1.07460865919036e-06 1.85716935368812 0.441860465116279 25.3 25 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000160641069681121 0.000707715919988343 1.85716935368812 0.441860465116279 25.3 25 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000791726643544495 0.00288878721477902 1.85429447852761 0.441176470588235 25.3 25 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000791726643544495 0.00288878721477902 1.85429447852761 0.441176470588235 25.3 25 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.98897861971444e-22 3.14479619539294e-20 1.85049728846919 0.440273037542662 25.3 25 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 5.40193045592296e-05 0.000278512573868781 1.84934969325153 0.44 25.3 25 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00402306335558179 0.0116358112906359 1.84934969325153 0.44 25.3 25 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00402306335558179 0.0116358112906359 1.84934969325153 0.44 25.3 25 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.48924676414684e-09 5.65327269502739e-08 1.84620721288917 0.439252336448598 25.3 25 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0216433672358626 0.0505722685987398 1.83884202453988 0.4375 25.3 25 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0216433672358626 0.0505722685987398 1.83884202453988 0.4375 25.3 25 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 8.78359782525047e-05 0.000415251153001044 1.83884202453988 0.4375 25.3 25 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 8.2986304822871e-17 7.38059448518409e-15 1.82824011664695 0.434977578475336 25.3 25 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.62828765024808e-05 0.000100305338800997 1.82132924335378 0.433333333333333 25.3 25 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00213689464732462 0.00661043713726726 1.82132924335378 0.433333333333333 25.3 25 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000699097245044651 0.00257724191631746 1.8175426960703 0.432432432432432 25.3 25 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000699097245044651 0.00257724191631746 1.8175426960703 0.432432432432432 25.3 25 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 9.26147837063866e-09 1.07147022125356e-07 1.81233185118478 0.431192660550459 25.3 25 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.63070876302346e-05 0.000142881624800854 1.81166701925111 0.431034482758621 25.3 25 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.63070876302346e-05 0.000142881624800854 1.81166701925111 0.431034482758621 25.3 25 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 8.94384342657086e-06 5.89217092407886e-05 1.81055214723926 0.430769230769231 25.3 25 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.78416788651477e-09 2.4649232063209e-08 1.80627693555747 0.429752066115702 25.3 25 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.78416788651477e-09 2.4649232063209e-08 1.80627693555747 0.429752066115702 25.3 25 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.24480228147021e-18 1.36257972810162e-16 1.80361516583222 0.42911877394636 25.3 25 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00351283854838302 0.0103067407306166 1.80131463628396 0.428571428571429 25.3 25 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0367071838519673 0.0789147056202305 1.80131463628396 0.428571428571429 25.3 25 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0367071838519673 0.0789147056202305 1.80131463628396 0.428571428571429 25.3 25 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0367071838519673 0.0789147056202305 1.80131463628396 0.428571428571429 25.3 25 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00114125836835046 0.0037767689724714 1.80131463628396 0.428571428571429 25.3 25 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00114125836835046 0.0037767689724714 1.80131463628396 0.428571428571429 25.3 25 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0110976261599227 0.0283009355296954 1.80131463628396 0.428571428571429 25.3 25 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 8.78804985322333e-10 1.26317120617543e-08 1.7920055167166 0.426356589147287 25.3 25 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 6.85539204704204e-05 0.000341091709193735 1.79019541013406 0.425925925925926 25.3 25 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000203914193074543 0.000874005713087575 1.78853935517556 0.425531914893617 25.3 25 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000612294278633373 0.00232345268932077 1.7863036809816 0.425 25.3 25 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.3756361951492e-28 3.91506061139462e-26 1.78581036320171 0.424882629107981 25.3 25 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00186274074398338 0.00583850237596553 1.78311953894776 0.424242424242424 25.3 25 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000329750187814931 0.00136010005003086 1.7746284935242 0.422222222222222 25.3 25 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.80052699884399e-10 5.63348949932812e-09 1.77129272567923 0.421428571428571 25.3 25 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 7.33025135826763e-11 1.25674068467649e-09 1.76971262512109 0.421052631578947 25.3 25 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.81015899298217e-06 2.75221129290032e-05 1.76971262512109 0.421052631578947 25.3 25 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000993819569086907 0.00337519151983453 1.76971262512109 0.421052631578947 25.3 25 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000993819569086907 0.00337519151983453 1.76971262512109 0.421052631578947 25.3 25 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0184763127971876 0.0441137468295267 1.76971262512109 0.421052631578947 25.3 25 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0184763127971876 0.0441137468295267 1.76971262512109 0.421052631578947 25.3 25 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 6.00694615564165e-05 0.000306375784210683 1.76971262512108 0.421052631578947 25.3 25 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 9.55053887057846e-13 3.77788267449273e-11 1.76850380502196 0.420765027322404 25.3 25 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 2.08996940527598e-06 1.59038848326616e-05 1.76425054911762 0.419753086419753 25.3 25 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00303942954298244 0.0091028608706661 1.76257668711656 0.419354838709677 25.3 25 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.66998969709341e-11 9.96098189995546e-10 1.75571173409956 0.417721518987342 25.3 25 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 8.49556478126007e-15 5.25616899292743e-13 1.75284877163058 0.417040358744395 25.3 25 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00950231915260018 0.0246249505485612 1.75127811860941 0.416666666666667 25.3 25 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00950231915260018 0.0246249505485612 1.75127811860941 0.416666666666667 25.3 25 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00950231915260018 0.0246249505485612 1.75127811860941 0.416666666666667 25.3 25 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00950231915260018 0.0246249505485612 1.75127811860941 0.416666666666667 25.3 25 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00950231915260018 0.0246249505485612 1.75127811860941 0.416666666666667 25.3 25 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.062603413240749 0.120710917400523 1.75127811860941 0.416666666666667 25.3 25 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.062603413240749 0.120710917400523 1.75127811860941 0.416666666666667 25.3 25 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.062603413240749 0.120710917400523 1.75127811860941 0.416666666666667 25.3 25 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.062603413240749 0.120710917400523 1.75127811860941 0.416666666666667 25.3 25 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.062603413240749 0.120710917400523 1.75127811860941 0.416666666666667 25.3 25 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.062603413240749 0.120710917400523 1.75127811860941 0.416666666666667 25.3 25 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.062603413240749 0.120710917400523 1.75127811860941 0.416666666666667 25.3 25 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.062603413240749 0.120710917400523 1.75127811860941 0.416666666666667 25.3 25 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00161199010785721 0.00519635198295517 1.75127811860941 0.416666666666667 25.3 25 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.1051484163133e-08 1.26824693259179e-07 1.74273529851863 0.414634146341463 25.3 25 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000860227488006692 0.00304503411799384 1.74273529851863 0.414634146341463 25.3 25 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.000461313655908492 0.00179849132152818 1.73604961323019 0.41304347826087 25.3 25 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.16450575689318e-11 2.71654375747376e-10 1.73346851062355 0.412429378531073 25.3 25 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 5.03813553891808e-08 5.23304151232148e-07 1.73284361209773 0.412280701754386 25.3 25 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00261245061429059 0.00790961111518195 1.73067484662577 0.411764705882353 25.3 25 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0308141360619919 0.0679821947538208 1.73067484662577 0.411764705882353 25.3 25 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0308141360619919 0.0679821947538208 1.73067484662577 0.411764705882353 25.3 25 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.72198505469095e-10 4.16492982024217e-09 1.72433537832311 0.41025641025641 25.3 25 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00138729140653056 0.00453819694596088 1.72433537832311 0.41025641025641 25.3 25 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.55876190659173e-09 3.43501716328304e-08 1.72356004766739 0.410071942446043 25.3 25 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0156320308068494 0.0382863680518876 1.71943669827105 0.409090909090909 25.3 25 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.84898877184834e-14 4.66374482308896e-12 1.71943669827105 0.409090909090909 25.3 25 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 7.54912216533685e-31 2.68560021031859e-28 1.71798385779934 0.408745247148289 25.3 25 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 6.61849195918415e-07 5.50766903971874e-06 1.71553774884187 0.408163265306122 25.3 25 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000397730330823297 0.00158980410326279 1.71553774884187 0.408163265306122 25.3 25 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.5827761205018e-19 1.87690868289505e-17 1.71474839098197 0.407975460122699 25.3 25 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 8.23517837238925e-17 7.38059448518409e-15 1.71460875728112 0.407942238267148 25.3 25 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0080794075869573 0.0219827858436716 1.71236082708475 0.407407407407407 25.3 25 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0080794075869573 0.0219827858436716 1.71236082708475 0.407407407407407 25.3 25 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.51117439121653e-09 4.50126230513614e-08 1.71124890446976 0.407142857142857 25.3 25 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 6.48941454341926e-22 9.23443689528561e-20 1.70819854991634 0.406417112299465 25.3 25 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.24620593077755e-10 4.91420323350686e-09 1.70749616564417 0.40625 25.3 25 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.01158680389954e-05 6.51352046130787e-05 1.70250834821775 0.40506329113924 25.3 25 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.000341740269714172 0.00138941829658076 1.69739263803681 0.403846153846154 25.3 25 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.000341740269714172 0.00138941829658076 1.69739263803681 0.403846153846154 25.3 25 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 9.96937850094022e-05 0.000466658737067037 1.69478527607362 0.403225806451613 25.3 25 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.10634660889098e-08 7.22309373175133e-07 1.68811726843005 0.401639344262295 25.3 25 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.23009782625834e-06 9.77893411600904e-06 1.68122699386503 0.4 25.3 25 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.5270773131995e-05 0.000139381047158252 1.68122699386503 0.4 25.3 25 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0131551563506124 0.0327922467020778 1.68122699386503 0.4 25.3 25 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0131551563506124 0.0327922467020778 1.68122699386503 0.4 25.3 25 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0131551563506124 0.0327922467020778 1.68122699386503 0.4 25.3 25 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0131551563506124 0.0327922467020778 1.68122699386503 0.4 25.3 25 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0131551563506124 0.0327922467020778 1.68122699386503 0.4 25.3 25 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0257115913646861 0.0582605008152044 1.68122699386503 0.4 25.3 25 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0257115913646861 0.0582605008152044 1.68122699386503 0.4 25.3 25 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00359324544491736 0.0105209635146449 1.68122699386503 0.4 25.3 25 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.00683734298067219 0.0190030059794854 1.68122699386503 0.4 25.3 25 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.051479338735363 0.101602079085189 1.68122699386503 0.4 25.3 25 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.051479338735363 0.101602079085189 1.68122699386503 0.4 25.3 25 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.000135315079176716 0.000605513703359958 1.66788392248515 0.396825396825397 25.3 25 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.98640192560054e-09 2.71793263473998e-08 1.66536636184744 0.39622641509434 25.3 25 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00086473127007086 0.00304582326067038 1.66371421267894 0.395833333333333 25.3 25 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00086473127007086 0.00304582326067038 1.66371421267894 0.395833333333333 25.3 25 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.1561084382639e-08 2.39698617785119e-07 1.66308425652116 0.39568345323741 25.3 25 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00161769777122217 0.00519635198295517 1.66167784277358 0.395348837209302 25.3 25 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00161769777122217 0.00519635198295517 1.66167784277358 0.395348837209302 25.3 25 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.10022533004133e-09 4.08483393023039e-08 1.65981008948458 0.394904458598726 25.3 25 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00304350237978875 0.0091028608706661 1.65910558605102 0.394736842105263 25.3 25 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.011034246376623 0.0282405262480836 1.6512050832603 0.392857142857143 25.3 25 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.011034246376623 0.0282405262480836 1.6512050832603 0.392857142857143 25.3 25 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.43408447765695e-44 2.04070221170584e-41 1.64984662576687 0.392533936651584 25.3 25 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 5.14356422462398e-14 2.92771675665597e-12 1.64889570552147 0.392307692307692 25.3 25 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000734912148181168 0.00270227386785995 1.64826175869121 0.392156862745098 25.3 25 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 9.85883425906128e-05 0.000463007298701129 1.64467858095492 0.391304347826087 25.3 25 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0213890474789532 0.0503084538223974 1.64467858095492 0.391304347826087 25.3 25 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0213890474789532 0.0503084538223974 1.64467858095492 0.391304347826087 25.3 25 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.000181819814735519 0.000788809745026351 1.64182323619632 0.390625 25.3 25 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.34145373537421e-10 2.16919166526989e-09 1.64182323619632 0.390625 25.3 25 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.42905184822474e-10 3.75710954350414e-09 1.64076965978806 0.390374331550802 25.3 25 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 3.05229504612131e-09 4.05926715012208e-08 1.6402214574293 0.390243902439024 25.3 25 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00257194250755341 0.00780356969775801 1.6402214574293 0.390243902439024 25.3 25 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.000336179228831859 0.00137862548307705 1.63848393469897 0.389830508474576 25.3 25 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.000336179228831859 0.00137862548307705 1.63848393469897 0.389830508474576 25.3 25 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 8.39631707889416e-05 0.00040501556621242 1.63452624403545 0.388888888888889 25.3 25 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 8.39631707889416e-05 0.00040501556621242 1.63452624403545 0.388888888888889 25.3 25 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0422647314091333 0.0889685100520662 1.63452624403545 0.388888888888889 25.3 25 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0422647314091333 0.0889685100520662 1.63452624403545 0.388888888888889 25.3 25 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0422647314091333 0.0889685100520662 1.63452624403545 0.388888888888889 25.3 25 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.58889266015414e-07 3.17204612136605e-06 1.62699386503067 0.387096774193548 25.3 25 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.58889266015414e-07 3.17204612136605e-06 1.62699386503067 0.387096774193548 25.3 25 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.58889266015414e-07 3.17204612136605e-06 1.62699386503067 0.387096774193548 25.3 25 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00923602515184466 0.0244554294892803 1.62699386503067 0.387096774193548 25.3 25 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00216965422383395 0.00669721900328787 1.623912437256 0.386363636363636 25.3 25 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.06369854094067e-07 2.81267291855392e-06 1.62165595864934 0.385826771653543 25.3 25 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000131317965695082 0.000591346408810449 1.62118317265557 0.385714285714286 25.3 25 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000980644572223042 0.00335725720942239 1.61656441717791 0.384615384615385 25.3 25 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.0177666289427408 0.0425621430732663 1.61656441717791 0.384615384615385 25.3 25 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0177666289427408 0.0425621430732663 1.61656441717791 0.384615384615385 25.3 25 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0177666289427408 0.0425621430732663 1.61656441717791 0.384615384615385 25.3 25 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0177666289427408 0.0425621430732663 1.61656441717791 0.384615384615385 25.3 25 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0861350311150254 0.159356333199311 1.61656441717791 0.384615384615385 25.3 25 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0861350311150254 0.159356333199311 1.61656441717791 0.384615384615385 25.3 25 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0861350311150254 0.159356333199311 1.61656441717791 0.384615384615385 25.3 25 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.0861350311150254 0.159356333199311 1.61656441717791 0.384615384615385 25.3 25 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0861350311150254 0.159356333199311 1.61656441717791 0.384615384615385 25.3 25 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.57391803786787e-09 2.21751026523364e-08 1.60773073183814 0.382513661202186 25.3 25 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00772066281806204 0.0211278907501967 1.60705521472393 0.382352941176471 25.3 25 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.000827713296157892 0.00299198371692005 1.60480758505298 0.381818181818182 25.3 25 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.40990820074075e-10 2.25426895466751e-09 1.60116856558574 0.380952380952381 25.3 25 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 5.18290418415916e-06 3.63313923845246e-05 1.60116856558574 0.380952380952381 25.3 25 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0347048007214636 0.0759768175794504 1.60116856558574 0.380952380952381 25.3 25 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00153828243144453 0.00497494522714901 1.59716564417178 0.38 25.3 25 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00153828243144453 0.00497494522714901 1.59716564417178 0.38 25.3 25 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 9.6266431856112e-07 7.82783614464271e-06 1.5930981595092 0.379032258064516 25.3 25 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.00644860000464279 0.0179576473710503 1.59034985906152 0.378378378378378 25.3 25 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000588135622833863 0.00224977685831341 1.58476314995474 0.377049180327869 25.3 25 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.000269216828916729 0.00112016241973247 1.58376455943807 0.376811594202899 25.3 25 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 4.87301075456499e-06 3.50216884027575e-05 1.57615030674847 0.375 25.3 25 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0122400750279021 0.0309922184425351 1.57615030674847 0.375 25.3 25 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0693809216350633 0.132167404935335 1.57615030674847 0.375 25.3 25 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0285210844747651 0.063514089526746 1.57615030674847 0.375 25.3 25 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0285210844747651 0.063514089526746 1.57615030674847 0.375 25.3 25 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.38481746040581e-23 6.88085035165352e-21 1.57418257852531 0.374531835205993 25.3 25 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.8989390316868e-05 0.000106805938422542 1.57084340335874 0.373737373737374 25.3 25 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 8.83005822160864e-05 0.000416065326137387 1.56982038583783 0.373493975903614 25.3 25 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.000416851739629645 0.00164772229303607 1.5683087629338 0.373134328358209 25.3 25 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.000416851739629645 0.00164772229303607 1.5683087629338 0.373134328358209 25.3 25 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 7.47878787558954e-06 4.99639208777649e-05 1.56659788064696 0.372727272727273 25.3 25 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000350702520820431 0.00141775479297578 1.5611393514461 0.371428571428571 25.3 25 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0234649944461429 0.0546492423843883 1.55669166098614 0.37037037037037 25.3 25 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 9.67116811831044e-06 6.25548737834352e-05 1.55248438622672 0.369369369369369 25.3 25 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.68051124006818e-11 6.71457371104746e-10 1.55113204791119 0.369047619047619 25.3 25 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.68051124006818e-11 6.71457371104746e-10 1.55113204791119 0.369047619047619 25.3 25 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.68051124006818e-11 6.71457371104746e-10 1.55113204791119 0.369047619047619 25.3 25 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0561413089327682 0.109888696851897 1.54849854698095 0.368421052631579 25.3 25 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0193278843095583 0.0459926076463235 1.54112474437628 0.366666666666667 25.3 25 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0193278843095583 0.0459926076463235 1.54112474437628 0.366666666666667 25.3 25 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.89190881112942e-05 0.000106805938422542 1.52838817624094 0.363636363636364 25.3 25 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000123671897010521 0.000569531098530651 1.52838817624094 0.363636363636364 25.3 25 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000829005714005577 0.00299198371692005 1.52838817624094 0.363636363636364 25.3 25 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0159386762679624 0.0388368772762167 1.52838817624094 0.363636363636364 25.3 25 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0159386762679624 0.0388368772762167 1.52838817624094 0.363636363636364 25.3 25 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0159386762679624 0.0388368772762167 1.52838817624094 0.363636363636364 25.3 25 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0456035263869575 0.0945974024032661 1.52838817624094 0.363636363636364 25.3 25 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0456035263869575 0.0945974024032661 1.52838817624094 0.363636363636364 25.3 25 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0456035263869575 0.0945974024032661 1.52838817624094 0.363636363636364 25.3 25 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0456035263869575 0.0945974024032661 1.52838817624094 0.363636363636364 25.3 25 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 7.44531734926488e-06 4.99639208777649e-05 1.52838817624094 0.363636363636364 25.3 25 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0131583786836869 0.0327922467020778 1.51777436946149 0.361111111111111 25.3 25 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.000188179424579326 0.000811452488413275 1.51505920958767 0.36046511627907 25.3 25 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.36624055515753e-18 1.38868593570655e-16 1.51207915606763 0.359756097560976 25.3 25 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 5.65418596481274e-06 3.91410863098494e-05 1.50797077694001 0.358778625954198 25.3 25 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 5.65418596481274e-06 3.91410863098494e-05 1.50797077694001 0.358778625954198 25.3 25 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.37116195056354e-08 8.38884750398022e-07 1.50762203254201 0.358695652173913 25.3 25 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000132376490000767 0.000594232634924578 1.50762203254201 0.358695652173913 25.3 25 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0303709655958761 0.0672128834260213 1.50109553023663 0.357142857142857 25.3 25 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.113594946261169 0.196307657095821 1.50109553023663 0.357142857142857 25.3 25 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.113594946261169 0.196307657095821 1.50109553023663 0.357142857142857 25.3 25 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.113594946261169 0.196307657095821 1.50109553023663 0.357142857142857 25.3 25 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.113594946261169 0.196307657095821 1.50109553023663 0.357142857142857 25.3 25 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.113594946261169 0.196307657095821 1.50109553023663 0.357142857142857 25.3 25 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00899565497496135 0.0239267608025608 1.50109553023663 0.357142857142857 25.3 25 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.83069720334146e-06 2.09795943768484e-05 1.49899609592861 0.356643356643357 25.3 25 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0248784068463009 0.0567218362067623 1.49141104294479 0.354838709677419 25.3 25 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.63498926002761e-16 3.47136300895752e-14 1.48897906407329 0.354260089686099 25.3 25 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00617214097559672 0.0172214835456355 1.488586400818 0.354166666666667 25.3 25 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 7.21952117739997e-27 1.71222977257336e-24 1.48533498817781 0.353393085787452 25.3 25 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0204212290588172 0.0482714434396959 1.48343558282209 0.352941176470588 25.3 25 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0204212290588172 0.0482714434396959 1.48343558282209 0.352941176470588 25.3 25 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0204212290588172 0.0482714434396959 1.48343558282209 0.352941176470588 25.3 25 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.0904173501294658 0.163029947947289 1.48343558282209 0.352941176470588 25.3 25 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0904173501294658 0.163029947947289 1.48343558282209 0.352941176470588 25.3 25 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0904173501294658 0.163029947947289 1.48343558282209 0.352941176470588 25.3 25 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0904173501294658 0.163029947947289 1.48343558282209 0.352941176470588 25.3 25 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0904173501294658 0.163029947947289 1.48343558282209 0.352941176470588 25.3 25 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.92140712556581e-05 0.000343176388142165 1.47885707793683 0.351851851851852 25.3 25 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0138311004499889 0.0344084894061786 1.4710736196319 0.35 25.3 25 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0725265414694282 0.137241048551857 1.4710736196319 0.35 25.3 25 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0725265414694282 0.137241048551857 1.4710736196319 0.35 25.3 25 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0725265414694282 0.137241048551857 1.4710736196319 0.35 25.3 25 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0725265414694282 0.137241048551857 1.4710736196319 0.35 25.3 25 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.09165114544715e-32 2.19970978998565e-29 1.46413161627886 0.348348348348348 25.3 25 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000378731190582242 0.00152241379717099 1.46398979802854 0.348314606741573 25.3 25 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0094209485701925 0.0246249505485612 1.46193651640437 0.347826086956522 25.3 25 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0585179151378932 0.114383232474206 1.46193651640437 0.347826086956522 25.3 25 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.000264482503014196 0.00110369091433783 1.46001291572489 0.347368421052632 25.3 25 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.000264482503014196 0.00110369091433783 1.46001291572489 0.347368421052632 25.3 25 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00778895398783865 0.0212738608919278 1.45820708651559 0.346938775510204 25.3 25 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000975847678921462 0.00335725720942239 1.45490797546012 0.346153846153846 25.3 25 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000813613923064776 0.00295350156255402 1.4529122169204 0.345679012345679 25.3 25 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000813613923064776 0.00295350156255402 1.4529122169204 0.345679012345679 25.3 25 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 2.87340014596042e-07 2.6724499396743e-06 1.45080502008657 0.345177664974619 25.3 25 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0385935689854775 0.0819681323378127 1.44933361540089 0.344827586206897 25.3 25 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0385935689854775 0.0819681323378127 1.44933361540089 0.344827586206897 25.3 25 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 5.13522436719317e-06 3.61753676956232e-05 1.44564104568012 0.343949044585987 25.3 25 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0314984854178429 0.0693844345968893 1.44480444785276 0.34375 25.3 25 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00101170387521152 0.00342774908196665 1.43519377525064 0.341463414634146 25.3 25 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000843138067803893 0.00299198371692005 1.43398773006135 0.341176470588235 25.3 25 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000843138067803893 0.00299198371692005 1.43398773006135 0.341176470588235 25.3 25 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000843138067803893 0.00299198371692005 1.43398773006135 0.341176470588235 25.3 25 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000843138067803893 0.00299198371692005 1.43398773006135 0.341176470588235 25.3 25 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000843138067803893 0.00299198371692005 1.43398773006135 0.341176470588235 25.3 25 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000843138067803893 0.00299198371692005 1.43398773006135 0.341176470588235 25.3 25 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000843138067803893 0.00299198371692005 1.43398773006135 0.341176470588235 25.3 25 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000340790587417932 0.00138941829658076 1.42904294478528 0.34 25.3 25 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.12921804308219e-06 9.07840268534441e-06 1.42291347137014 0.338541666666667 25.3 25 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.9382245004841e-07 3.39642028132659e-06 1.42103710195735 0.338095238095238 25.3 25 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 2.8470513041745e-08 3.04613083145888e-07 1.41750511247444 0.337254901960784 25.3 25 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00104143901129881 0.00352011333272734 1.4173134541304 0.337209302325581 25.3 25 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.000603225984514092 0.00229516196781699 1.41577010009687 0.336842105263158 25.3 25 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.017722497360132 0.0425621430732663 1.40102249488753 0.333333333333333 25.3 25 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0392783899927834 0.0831743288091233 1.40102249488753 0.333333333333333 25.3 25 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0392783899927834 0.0831743288091233 1.40102249488753 0.333333333333333 25.3 25 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.05941825877766 0.11598378908177 1.40102249488753 0.333333333333333 25.3 25 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0145932906685101 0.035989168375534 1.40102249488753 0.333333333333333 25.3 25 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0145932906685101 0.035989168375534 1.40102249488753 0.333333333333333 25.3 25 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.021557655040298 0.0505379623102868 1.40102249488753 0.333333333333333 25.3 25 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.021557655040298 0.0505379623102868 1.40102249488753 0.333333333333333 25.3 25 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0320835012148077 0.0705638674322586 1.40102249488753 0.333333333333333 25.3 25 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.048226411323437 0.0982369563287832 1.40102249488753 0.333333333333333 25.3 25 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0735163304694572 0.138561242725878 1.40102249488753 0.333333333333333 25.3 25 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0735163304694572 0.138561242725878 1.40102249488753 0.333333333333333 25.3 25 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0735163304694572 0.138561242725878 1.40102249488753 0.333333333333333 25.3 25 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.114493659489632 0.196768692576989 1.40102249488753 0.333333333333333 25.3 25 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.114493659489632 0.196768692576989 1.40102249488753 0.333333333333333 25.3 25 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.114493659489632 0.196768692576989 1.40102249488753 0.333333333333333 25.3 25 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.114493659489632 0.196768692576989 1.40102249488753 0.333333333333333 25.3 25 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.144652750024072 0.237966315935554 1.40102249488753 0.333333333333333 25.3 25 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.144652750024072 0.237966315935554 1.40102249488753 0.333333333333333 25.3 25 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 3.71503822386503e-07 3.26327122997527e-06 1.3889965507254 0.330472103004292 25.3 25 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.000753367451847769 0.00276299454633859 1.38701226993865 0.33 25.3 25 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 2.54889028694862e-05 0.000139830160912803 1.38361848873985 0.329192546583851 25.3 25 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 3.63440122711669e-05 0.000194426802488235 1.38294478527607 0.329032258064516 25.3 25 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0100579058140788 0.0258346569917584 1.37686693463084 0.327586206896552 25.3 25 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0100579058140788 0.0258346569917584 1.37686693463084 0.327586206896552 25.3 25 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0100579058140788 0.0258346569917584 1.37686693463084 0.327586206896552 25.3 25 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0121720046513655 0.0308747996771714 1.37554935861684 0.327272727272727 25.3 25 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 3.08664853799597e-05 0.00016700763762617 1.37507763387109 0.327160493827161 25.3 25 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0217393758068768 0.0507133307757143 1.3705654841291 0.326086956521739 25.3 25 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.000182926713236154 0.000791199735364884 1.36918107454917 0.325757575757576 25.3 25 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0322609409807118 0.0707354684369075 1.36599693251534 0.325 25.3 25 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0322609409807118 0.0707354684369075 1.36599693251534 0.325 25.3 25 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0394230175731943 0.0833565438434702 1.36315702205273 0.324324324324324 25.3 25 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0083692118810381 0.0227278406616741 1.35791411042945 0.323076923076923 25.3 25 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 7.6730814464011e-05 0.000376263911575249 1.34815372149554 0.320754716981132 25.3 25 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 7.6730814464011e-05 0.000376263911575249 1.34815372149554 0.320754716981132 25.3 25 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0906231123164483 0.163029947947289 1.34498159509202 0.32 25.3 25 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.0906231123164483 0.163029947947289 1.34498159509202 0.32 25.3 25 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 7.69450444612772e-05 0.000376263911575249 1.34085588467763 0.319018404907975 25.3 25 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.68131116817934e-14 9.96877413466332e-13 1.33347708689139 0.317262830482115 25.3 25 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000155933411233873 0.000689109453993172 1.32871165644172 0.316129032258064 25.3 25 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.1414255135928 0.235103394675882 1.32728446884081 0.315789473684211 25.3 25 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.14342868185825e-12 6.3543729464256e-11 1.31759908888722 0.313485113835377 25.3 25 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.178867217473621 0.285665600970778 1.31345858895706 0.3125 25.3 25 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.178867217473621 0.285665600970778 1.31345858895706 0.3125 25.3 25 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.59709535167126e-31 1.70622222847607e-28 1.31328900101787 0.312459651387992 25.3 25 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.000448083038857238 0.00175170924256552 1.31159552712875 0.312056737588652 25.3 25 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00471346594464536 0.013604993994382 1.30762099522836 0.311111111111111 25.3 25 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0887402731853146 0.162457801825194 1.3044002538608 0.310344827586207 25.3 25 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0470716235147853 0.0972175910907686 1.30094945953842 0.30952380952381 25.3 25 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0257912092939071 0.0583479981323207 1.2991299498048 0.309090909090909 25.3 25 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.109818345642061 0.191274792960407 1.29325153374233 0.307692307692308 25.3 25 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.109818345642061 0.191274792960407 1.29325153374233 0.307692307692308 25.3 25 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0378979990635836 0.0807318153704782 1.2866533116314 0.306122448979592 25.3 25 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0460337033086368 0.0952121508839974 1.27919445185383 0.304347826086957 25.3 25 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0460337033086368 0.0952121508839974 1.27919445185383 0.304347826086957 25.3 25 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.136586589812444 0.227591003867808 1.27919445185383 0.304347826086957 25.3 25 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0115635416654954 0.0294363502504471 1.27688126116331 0.30379746835443 25.3 25 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0862293580909834 0.159356333199311 1.27365681353411 0.303030303030303 25.3 25 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.00370762093549303 0.0108335617889252 1.27248832104463 0.302752293577982 25.3 25 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0370079620066333 0.0789540178942118 1.26885056140757 0.30188679245283 25.3 25 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.170953644502817 0.273949365008455 1.26092024539877 0.3 25.3 25 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00142430466441021 0.00464859068223792 1.26092024539877 0.3 25.3 25 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.020055570009326 0.0476445344295007 1.26092024539877 0.3 25.3 25 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.106103356840405 0.187326397994909 1.26092024539877 0.3 25.3 25 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00169434475604935 0.00539385366411236 1.25785231292822 0.299270072992701 25.3 25 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00169434475604935 0.00539385366411236 1.25785231292822 0.299270072992701 25.3 25 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.011062255196212 0.0282613808693171 1.25608913334744 0.298850574712644 25.3 25 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.131039434848124 0.223316306333989 1.24535332878891 0.296296296296296 25.3 25 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.131039434848124 0.223316306333989 1.24535332878891 0.296296296296296 25.3 25 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.131039434848124 0.223316306333989 1.24535332878891 0.296296296296296 25.3 25 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00192271745968794 0.00596330708043352 1.24316080532273 0.295774647887324 25.3 25 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.012894323864887 0.0324754386897949 1.24181539319576 0.295454545454545 25.3 25 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0349494217858371 0.0763948190495333 1.24024942170371 0.295081967213115 25.3 25 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00271113562561735 0.00819096814278873 1.2361963190184 0.294117647058824 25.3 25 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.0281674032323449 0.0629234141281424 1.2361963190184 0.294117647058824 25.3 25 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.215721328867019 0.332940836201484 1.2361963190184 0.294117647058824 25.3 25 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.215721328867019 0.332940836201484 1.2361963190184 0.294117647058824 25.3 25 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0802900196677188 0.149937923867669 1.23016609307197 0.292682926829268 25.3 25 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0507697377821447 0.100480301618904 1.22271054099275 0.290909090909091 25.3 25 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.125231976536865 0.214188825254759 1.22024539877301 0.290322580645161 25.3 25 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.125231976536865 0.214188825254759 1.22024539877301 0.290322580645161 25.3 25 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0213302700529525 0.0503084538223974 1.21534481484219 0.289156626506024 25.3 25 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.061256597732341 0.119408409004276 1.21242331288344 0.288461538461538 25.3 25 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.154184207620814 0.252478857818663 1.20087642418931 0.285714285714286 25.3 25 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0739671830542146 0.139226589267391 1.20087642418931 0.285714285714286 25.3 25 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.119400462629016 0.20495399073714 1.20087642418931 0.285714285714286 25.3 25 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.202760137566579 0.313958297886009 1.20087642418931 0.285714285714286 25.3 25 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.202760137566579 0.313958297886009 1.20087642418931 0.285714285714286 25.3 25 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.202760137566579 0.313958297886009 1.20087642418931 0.285714285714286 25.3 25 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0236672825398733 0.0550302991082349 1.19405326268823 0.284090909090909 25.3 25 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0708284276240678 0.134744455226001 1.1895474013196 0.283018867924528 25.3 25 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.0893892535239968 0.162457801825194 1.18782341957855 0.282608695652174 25.3 25 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.113673583588866 0.196307657095821 1.18548057259714 0.282051282051282 25.3 25 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.146061179181483 0.239729017272492 1.18211273006135 0.28125 25.3 25 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.146061179181483 0.239729017272492 1.18211273006135 0.28125 25.3 25 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.190530868266844 0.298898920956713 1.17685889570552 0.28 25.3 25 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0259968128395418 0.0587197851915365 1.17505112474438 0.279569892473118 25.3 25 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.0495672063556334 0.0982369563287832 1.1675187457396 0.277777777777778 25.3 25 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.254655047858321 0.375517236375535 1.1675187457396 0.277777777777778 25.3 25 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0881652266353898 0.162457801825194 1.13981491109494 0.271186440677966 25.3 25 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.220267060812817 0.338854083823393 1.13159509202454 0.269230769230769 25.3 25 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.205665002416546 0.318110106998636 1.12081799591002 0.266666666666667 25.3 25 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.132965547862004 0.224959699960671 1.11509953674721 0.26530612244898 25.3 25 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0805842557957585 0.15029016513416 1.10607039070068 0.263157894736842 25.3 25 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.295094167238865 0.430244877029615 1.10607039070068 0.263157894736842 25.3 25 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.295094167238865 0.430244877029615 1.10607039070068 0.263157894736842 25.3 25 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.112122598123168 0.195049458593237 1.1024439304033 0.262295081967213 25.3 25 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.048019998304086 0.0982369563287832 1.09986812682759 0.261682242990654 25.3 25 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.149712869473472 0.245439416199022 1.09279754601227 0.26 25.3 25 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.141014795075373 0.234694799289188 1.0896841626903 0.259259259259259 25.3 25 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.25149672990046 0.371244654199537 1.0896841626903 0.259259259259259 25.3 25 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.25149672990046 0.371244654199537 1.0896841626903 0.259259259259259 25.3 25 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00540084798307887 0.0153547072349253 1.0878527607362 0.258823529411765 25.3 25 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.217702744186787 0.335271650408872 1.08078878177038 0.257142857142857 25.3 25 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.217702744186787 0.335271650408872 1.08078878177038 0.257142857142857 25.3 25 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.000364537869976976 0.00146951101693268 1.06987172336866 0.254545454545455 25.3 25 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.0842044540700425 0.156836306468155 1.0613806779451 0.252525252525253 25.3 25 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0365760139541704 0.0789147056202305 1.05076687116564 0.25 25.3 25 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.283934237327008 0.415677386539437 1.05076687116564 0.25 25.3 25 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.124048929782535 0.212676659133189 1.02841012922595 0.24468085106383 25.3 25 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.235586374417647 0.360472484727217 1.02741649625085 0.244444444444444 25.3 25 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.293023089735025 0.428102522272013 1.01892545082729 0.242424242424242 25.3 25 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.131461337136527 0.223767323857987 1.0103527607362 0.240384615384615 25.3 25 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.34527867163128 0.482368616007522 1.00873619631902 0.24 25.3 25 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.189650333558626 0.298531443201245 0.988957055214724 0.235294117647059 25.3 25 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.189650333558626 0.298531443201245 0.988957055214724 0.235294117647059 25.3 25 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.201215397451043 0.312586801935408 0.985904718624555 0.234567901234568 25.3 25 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.284434045857614 0.415981137980868 0.98369664534656 0.234042553191489 25.3 25 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0988835145513502 0.174796572927418 0.976929199137788 0.232432432432432 25.3 25 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.329011913505131 0.467249454009782 0.969938650306748 0.230769230769231 25.3 25 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.329011913505131 0.467249454009782 0.969938650306748 0.230769230769231 25.3 25 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.329011913505131 0.467249454009782 0.969938650306748 0.230769230769231 25.3 25 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.176961560885895 0.283257931541764 0.959755567363896 0.228346456692913 25.3 25 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 1.95086221887451e-05 0.000108865762253272 0.957479275774353 0.22780487804878 25.3 25 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.38556180695966 0.527552357022689 0.949079754601227 0.225806451612903 25.3 25 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.420292276298635 0.5674344489307 0.934014996591684 0.222222222222222 25.3 25 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.237482215237201 0.36298302071164 0.930187066277783 0.221311475409836 25.3 25 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.274670934654266 0.403339553292886 0.877749032941582 0.208835341365462 25.3 25 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.340810502069576 0.482368616007522 0.871367649259315 0.207317073170732 25.3 25 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.540417670639802 0.708116340074068 0.840613496932515 0.2 25.3 25 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.540417670639802 0.708116340074068 0.840613496932515 0.2 25.3 25 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.540417670639802 0.708116340074068 0.840613496932515 0.2 25.3 25 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.577949936297655 0.738261004803917 0.808282208588957 0.192307692307692 25.3 25 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.577949936297655 0.738261004803917 0.808282208588957 0.192307692307692 25.3 25 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.581067946411048 0.741578195285131 0.793031600879731 0.188679245283019 25.3 25 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.624520745568282 0.785758639207485 0.769575736628359 0.183098591549296 25.3 25 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.656737454171992 0.806330800074844 0.768302658486708 0.182795698924731 25.3 25 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.62959959848 0.791448965227068 0.764194088120469 0.181818181818182 25.3 25 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.696896473341977 0.85269448113984 0.730968258202187 0.173913043478261 25.3 25 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.679781673183522 0.832469295129218 0.724666807700444 0.172413793103448 25.3 25 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.759915248644746 0.904903262612111 0.707885050048434 0.168421052631579 25.3 25 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.709787504911971 0.864009939683264 0.700511247443763 0.166666666666667 25.3 25 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.728584603645408 0.87491636370246 0.700511247443763 0.166666666666667 25.3 25 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.77479754689573 0.915119049910829 0.691644016463462 0.164556962025316 25.3 25 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.737754662710261 0.882205785745128 0.677914110429448 0.161290322580645 25.3 25 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.737754662710261 0.882205785745128 0.677914110429448 0.161290322580645 25.3 25 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.737754662710261 0.882205785745128 0.677914110429448 0.161290322580645 25.3 25 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.737754662710261 0.882205785745128 0.677914110429448 0.161290322580645 25.3 25 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.763692751348962 0.908641124723723 0.656729294478528 0.15625 25.3 25 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.787637957218419 0.920960405194585 0.636828406767057 0.151515151515152 25.3 25 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.787637957218419 0.920960405194585 0.636828406767057 0.151515151515152 25.3 25 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.809647961445067 0.9451427802595 0.618098159509202 0.147058823529412 25.3 25 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.879994435135177 1 0.553035195350339 0.131578947368421 25.3 25 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999661278750528 1 0.541632407817342 0.128865979381443 25.3 25 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.997071871006977 1 0.52296231375986 0.124423963133641 25.3 25 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.972780886312762 1 0.519967111504649 0.123711340206186 25.3 25 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.996444248136755 1 0.501502370329057 0.119318181818182 25.3 25 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999921485966619 1 0.465339614373357 0.110714285714286 25.3 25 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.451715061323938 0.107472712006717 25.3 25 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.966939991230945 1 0.437819529652352 0.104166666666667 25.3 25 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.996400339919877 1 0.428090206771188 0.101851851851852 25.3 25 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.994254112733567 1 0.420306748466258 0.1 25.3 25 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.376223943021334 0.0895117540687161 25.3 25 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 1.44191880094409e-09 2.05048848903079e-08 2.30998146160601 1 26.2 26 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 5.75626179310827e-07 4.42765434140166e-06 2.30998146160601 1 26.2 26 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 5.75626179310827e-07 4.42765434140166e-06 2.30998146160601 1 26.2 26 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 6.92735142555505e-05 0.000325334028995539 2.30998146160601 1 26.2 26 2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.000759631460680057 0.00275017061107082 2.30998146160601 1 26.2 26 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00251522252194522 0.00744108450879012 2.30998146160601 1 26.2 26 2 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00251522252194522 0.00744108450879012 2.30998146160601 1 26.2 26 2 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.00251522252194522 0.00744108450879012 2.30998146160601 1 26.2 26 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00251522252194522 0.00744108450879012 2.30998146160601 1 26.2 26 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00251522252194522 0.00744108450879012 2.30998146160601 1 26.2 26 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 1.65489996450469e-05 8.81993501681714e-05 2.11748300647218 0.916666666666667 26.2 26 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 5.04039503051553e-05 0.000240687319745758 2.09998314691455 0.909090909090909 26.2 26 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000152332478513275 0.000673196015293136 2.07898331544541 0.9 26.2 26 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000456123484770979 0.00179299369842294 2.0533168547609 0.888888888888889 26.2 26 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.000456123484770979 0.00179299369842294 2.0533168547609 0.888888888888889 26.2 26 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000456123484770979 0.00179299369842294 2.0533168547609 0.888888888888889 26.2 26 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000456123484770979 0.00179299369842294 2.0533168547609 0.888888888888889 26.2 26 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 3.24958722872199e-06 2.06435831538902e-05 2.02123377890526 0.875 26.2 26 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00135031272534725 0.00444376573866917 2.02123377890526 0.875 26.2 26 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00135031272534725 0.00444376573866917 2.02123377890526 0.875 26.2 26 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.00135031272534725 0.00444376573866917 2.02123377890526 0.875 26.2 26 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00135031272534725 0.00444376573866917 2.02123377890526 0.875 26.2 26 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 9.45800160920328e-06 5.27793579995932e-05 2.00198393339188 0.866666666666667 26.2 26 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00394099973090831 0.0111050348853119 1.97998410994801 0.857142857142857 26.2 26 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00394099973090831 0.0111050348853119 1.97998410994801 0.857142857142857 26.2 26 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000219678703605697 0.000944419320939295 1.92498455133834 0.833333333333333 26.2 26 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000219678703605697 0.000944419320939295 1.92498455133834 0.833333333333333 26.2 26 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.000219678703605697 0.000944419320939295 1.92498455133834 0.833333333333333 26.2 26 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.000219678703605697 0.000944419320939295 1.92498455133834 0.833333333333333 26.2 26 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.011293177828271 0.0275646518861572 1.92498455133834 0.833333333333333 26.2 26 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.011293177828271 0.0275646518861572 1.92498455133834 0.833333333333333 26.2 26 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.011293177828271 0.0275646518861572 1.92498455133834 0.833333333333333 26.2 26 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.011293177828271 0.0275646518861572 1.92498455133834 0.833333333333333 26.2 26 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.011293177828271 0.0275646518861572 1.92498455133834 0.833333333333333 26.2 26 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.011293177828271 0.0275646518861572 1.92498455133834 0.833333333333333 26.2 26 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 3.63611305912887e-05 0.000180285326938689 1.87685993755488 0.8125 26.2 26 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 3.63611305912887e-05 0.000180285326938689 1.87685993755488 0.8125 26.2 26 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 3.63611305912887e-05 0.000180285326938689 1.87685993755488 0.8125 26.2 26 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00167128750980179 0.00513659206576231 1.84798516928481 0.8 26.2 26 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00167128750980179 0.00513659206576231 1.84798516928481 0.8 26.2 26 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00167128750980179 0.00513659206576231 1.84798516928481 0.8 26.2 26 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00447997506736423 0.0122168675651952 1.79665224791579 0.777777777777778 26.2 26 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00447997506736423 0.0122168675651952 1.79665224791579 0.777777777777778 26.2 26 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.20162905175559e-06 8.46494129033764e-06 1.77690881662001 0.769230769230769 26.2 26 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000692342213264075 0.00260187383686157 1.77690881662001 0.769230769230769 26.2 26 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.000692342213264075 0.00260187383686157 1.77690881662001 0.769230769230769 26.2 26 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.0449305583692e-07 1.69182336311591e-06 1.77098578723127 0.766666666666667 26.2 26 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.000111488046866378 0.000502049021173593 1.76645641181636 0.764705882352941 26.2 26 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.32266638443733e-06 9.09253268142183e-06 1.73248609620451 0.75 26.2 26 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 4.68195887448734e-05 0.000227386603358208 1.73248609620451 0.75 26.2 26 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.000285203904553944 0.00115955758908646 1.73248609620451 0.75 26.2 26 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000285203904553944 0.00115955758908646 1.73248609620451 0.75 26.2 26 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000285203904553944 0.00115955758908646 1.73248609620451 0.75 26.2 26 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.000285203904553944 0.00115955758908646 1.73248609620451 0.75 26.2 26 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0117130607475915 0.0282025134413243 1.73248609620451 0.75 26.2 26 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0117130607475915 0.0282025134413243 1.73248609620451 0.75 26.2 26 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0117130607475915 0.0282025134413243 1.73248609620451 0.75 26.2 26 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0117130607475915 0.0282025134413243 1.73248609620451 0.75 26.2 26 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0117130607475915 0.0282025134413243 1.73248609620451 0.75 26.2 26 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0117130607475915 0.0282025134413243 1.73248609620451 0.75 26.2 26 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0117130607475915 0.0282025134413243 1.73248609620451 0.75 26.2 26 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00178500731098215 0.00539292017734098 1.73248609620451 0.75 26.2 26 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00178500731098215 0.00539292017734098 1.73248609620451 0.75 26.2 26 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.95955276040829e-05 0.000102516308016949 1.70737760205662 0.739130434782609 26.2 26 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000117442345431273 0.00052388858165737 1.70209160328864 0.736842105263158 26.2 26 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000117442345431273 0.00052388858165737 1.70209160328864 0.736842105263158 26.2 26 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 7.1556955362434e-12 1.56654688431913e-10 1.69398640517774 0.733333333333333 26.2 26 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 7.1556955362434e-12 1.56654688431913e-10 1.69398640517774 0.733333333333333 26.2 26 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 7.1556955362434e-12 1.56654688431913e-10 1.69398640517774 0.733333333333333 26.2 26 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 7.1556955362434e-12 1.56654688431913e-10 1.69398640517774 0.733333333333333 26.2 26 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 7.1556955362434e-12 1.56654688431913e-10 1.69398640517774 0.733333333333333 26.2 26 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 7.1556955362434e-12 1.56654688431913e-10 1.69398640517774 0.733333333333333 26.2 26 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 7.1556955362434e-12 1.56654688431913e-10 1.69398640517774 0.733333333333333 26.2 26 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 3.08564985709164e-09 3.95574751949677e-08 1.69398640517774 0.733333333333333 26.2 26 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00071671083724124 0.00263534760050203 1.69398640517774 0.733333333333333 26.2 26 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00071671083724124 0.00263534760050203 1.69398640517774 0.733333333333333 26.2 26 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00071671083724124 0.00263534760050203 1.69398640517774 0.733333333333333 26.2 26 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.77064379510974e-08 1.93817393880089e-07 1.6902303377605 0.731707317073171 26.2 26 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.77064379510974e-08 1.93817393880089e-07 1.6902303377605 0.731707317073171 26.2 26 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.01937395445551e-07 8.79132810418297e-07 1.68566214765844 0.72972972972973 26.2 26 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00449869192140708 0.0122168675651952 1.67998651753164 0.727272727272727 26.2 26 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00449869192140708 0.0122168675651952 1.67998651753164 0.727272727272727 26.2 26 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00449869192140708 0.0122168675651952 1.67998651753164 0.727272727272727 26.2 26 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00449869192140708 0.0122168675651952 1.67998651753164 0.727272727272727 26.2 26 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.00449869192140708 0.0122168675651952 1.67998651753164 0.727272727272727 26.2 26 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00449869192140708 0.0122168675651952 1.67998651753164 0.727272727272727 26.2 26 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00449869192140708 0.0122168675651952 1.67998651753164 0.727272727272727 26.2 26 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.20851707889537e-09 4.07209423377927e-08 1.67105041903414 0.723404255319149 26.2 26 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.48167831750269e-07 2.02955646310708e-06 1.66831994449323 0.722222222222222 26.2 26 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000289808729896487 0.0011649656006856 1.66831994449323 0.722222222222222 26.2 26 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.000289808729896487 0.0011649656006856 1.66831994449323 0.722222222222222 26.2 26 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000289808729896487 0.0011649656006856 1.66831994449323 0.722222222222222 26.2 26 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.00057553541526e-05 0.000104279083769081 1.66318665235633 0.72 26.2 26 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.43053248660046e-06 9.69356061158313e-06 1.66029917552932 0.71875 26.2 26 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00176467551077986 0.00535422868196106 1.64998675829001 0.714285714285714 26.2 26 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00176467551077986 0.00535422868196106 1.64998675829001 0.714285714285714 26.2 26 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00176467551077986 0.00535422868196106 1.64998675829001 0.714285714285714 26.2 26 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00176467551077986 0.00535422868196106 1.64998675829001 0.714285714285714 26.2 26 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0296736230716778 0.0622795953259551 1.64998675829001 0.714285714285714 26.2 26 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0296736230716778 0.0622795953259551 1.64998675829001 0.714285714285714 26.2 26 2 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0296736230716778 0.0622795953259551 1.64998675829001 0.714285714285714 26.2 26 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000117885334643616 0.000524221347493329 1.64998675829001 0.714285714285714 26.2 26 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.56923831964881e-14 1.80611836912785e-12 1.64586179139428 0.7125 26.2 26 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.34898298419156e-12 8.51000497590106e-11 1.64042161766224 0.710144927536232 26.2 26 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 4.81894139569109e-05 0.000231667351556366 1.63623686863759 0.708333333333333 26.2 26 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 4.81894139569109e-05 0.000231667351556366 1.63623686863759 0.708333333333333 26.2 26 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 4.81894139569109e-05 0.000231667351556366 1.63623686863759 0.708333333333333 26.2 26 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000702121963004106 0.00260187383686157 1.63057514936895 0.705882352941177 26.2 26 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000702121963004106 0.00260187383686157 1.63057514936895 0.705882352941177 26.2 26 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000702121963004106 0.00260187383686157 1.63057514936895 0.705882352941177 26.2 26 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000702121963004106 0.00260187383686157 1.63057514936895 0.705882352941177 26.2 26 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000702121963004106 0.00260187383686157 1.63057514936895 0.705882352941177 26.2 26 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.39212723680927e-08 4.0584396480387e-07 1.62748693885878 0.704545454545455 26.2 26 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000282228777699535 0.00115955758908646 1.61698702312421 0.7 26.2 26 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000282228777699535 0.00115955758908646 1.61698702312421 0.7 26.2 26 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000282228777699535 0.00115955758908646 1.61698702312421 0.7 26.2 26 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000282228777699535 0.00115955758908646 1.61698702312421 0.7 26.2 26 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000282228777699535 0.00115955758908646 1.61698702312421 0.7 26.2 26 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0110335793683432 0.027305710332439 1.61698702312421 0.7 26.2 26 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0110335793683432 0.027305710332439 1.61698702312421 0.7 26.2 26 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0110335793683432 0.027305710332439 1.61698702312421 0.7 26.2 26 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0110335793683432 0.027305710332439 1.61698702312421 0.7 26.2 26 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0110335793683432 0.027305710332439 1.61698702312421 0.7 26.2 26 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0110335793683432 0.027305710332439 1.61698702312421 0.7 26.2 26 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0110335793683432 0.027305710332439 1.61698702312421 0.7 26.2 26 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0110335793683432 0.027305710332439 1.61698702312421 0.7 26.2 26 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000114324477203147 0.000513197889779426 1.60694362546505 0.695652173913043 26.2 26 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.39379561186526e-06 9.48981414202996e-06 1.60415379278195 0.694444444444444 26.2 26 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.39379561186526e-06 9.48981414202996e-06 1.60415379278195 0.694444444444444 26.2 26 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.8044928388942e-08 1.96014756469194e-07 1.60284427948172 0.693877551020408 26.2 26 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 4.65897986540493e-05 0.000227045491386 1.59921793495801 0.692307692307692 26.2 26 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00424350378084783 0.0117709666279658 1.59921793495801 0.692307692307692 26.2 26 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00424350378084783 0.0117709666279658 1.59921793495801 0.692307692307692 26.2 26 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.00424350378084783 0.0117709666279658 1.59921793495801 0.692307692307692 26.2 26 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00424350378084783 0.0117709666279658 1.59921793495801 0.692307692307692 26.2 26 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00424350378084783 0.0117709666279658 1.59921793495801 0.692307692307692 26.2 26 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00424350378084783 0.0117709666279658 1.59921793495801 0.692307692307692 26.2 26 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00424350378084783 0.0117709666279658 1.59921793495801 0.692307692307692 26.2 26 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00424350378084783 0.0117709666279658 1.59921793495801 0.692307692307692 26.2 26 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.90781520320399e-05 0.000100548927191084 1.59309066317656 0.689655172413793 26.2 26 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.00179472012724e-07 8.69345681105809e-07 1.5913205624397 0.688888888888889 26.2 26 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00166602608915329 0.00513659206576231 1.58811225485413 0.6875 26.2 26 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00166602608915329 0.00513659206576231 1.58811225485413 0.6875 26.2 26 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00166602608915329 0.00513659206576231 1.58811225485413 0.6875 26.2 26 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00166602608915329 0.00513659206576231 1.58811225485413 0.6875 26.2 26 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00166602608915329 0.00513659206576231 1.58811225485413 0.6875 26.2 26 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00166602608915329 0.00513659206576231 1.58811225485413 0.6875 26.2 26 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00166602608915329 0.00513659206576231 1.58811225485413 0.6875 26.2 26 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 3.23501646140622e-06 2.06431767918433e-05 1.58398728795841 0.685714285714286 26.2 26 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000663269229571121 0.00253038100182227 1.58051363162516 0.684210526315789 26.2 26 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000663269229571121 0.00253038100182227 1.58051363162516 0.684210526315789 26.2 26 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 5.5471128096544e-07 4.31341067111378e-06 1.57754831524313 0.682926829268293 26.2 26 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 5.5471128096544e-07 4.31341067111378e-06 1.57754831524313 0.682926829268293 26.2 26 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 5.45862829482255e-13 1.84943525322202e-11 1.57622264438998 0.682352941176471 26.2 26 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.000108079688487772 0.000488245703866984 1.57078739389209 0.68 26.2 26 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 9.00581309135366e-11 1.6862200038153e-09 1.56167760784632 0.676056338028169 26.2 26 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.18051185622184e-07 1.79356553260328e-06 1.55672663716927 0.673913043478261 26.2 26 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.09400530121572e-05 0.000201583721232871 1.53998764107067 0.666666666666667 26.2 26 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00386060485785708 0.0109478701565907 1.53998764107067 0.666666666666667 26.2 26 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00386060485785708 0.0109478701565907 1.53998764107067 0.666666666666667 26.2 26 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 8.01003993972765e-11 1.51977157789766e-09 1.53998764107067 0.666666666666667 26.2 26 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 8.01003993972765e-11 1.51977157789766e-09 1.53998764107067 0.666666666666667 26.2 26 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 8.01003993972765e-11 1.51977157789766e-09 1.53998764107067 0.666666666666667 26.2 26 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 8.01003993972765e-11 1.51977157789766e-09 1.53998764107067 0.666666666666667 26.2 26 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 8.01003993972765e-11 1.51977157789766e-09 1.53998764107067 0.666666666666667 26.2 26 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 6.91745816048812e-06 3.9852400657387e-05 1.53998764107067 0.666666666666667 26.2 26 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000100209082558852 0.000455583145307498 1.53998764107067 0.666666666666667 26.2 26 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000100209082558852 0.000455583145307498 1.53998764107067 0.666666666666667 26.2 26 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000100209082558852 0.000455583145307498 1.53998764107067 0.666666666666667 26.2 26 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000100209082558852 0.000455583145307498 1.53998764107067 0.666666666666667 26.2 26 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000246594603695619 0.00103685849821224 1.53998764107067 0.666666666666667 26.2 26 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000246594603695619 0.00103685849821224 1.53998764107067 0.666666666666667 26.2 26 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000610915663811376 0.00234321560540051 1.53998764107067 0.666666666666667 26.2 26 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00152674842921935 0.00486031994357747 1.53998764107067 0.666666666666667 26.2 26 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00152674842921935 0.00486031994357747 1.53998764107067 0.666666666666667 26.2 26 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00152674842921935 0.00486031994357747 1.53998764107067 0.666666666666667 26.2 26 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00992606114225691 0.02499961947864 1.53998764107067 0.666666666666667 26.2 26 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00992606114225691 0.02499961947864 1.53998764107067 0.666666666666667 26.2 26 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00992606114225691 0.02499961947864 1.53998764107067 0.666666666666667 26.2 26 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.026179232108046 0.0567017462553264 1.53998764107067 0.666666666666667 26.2 26 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.41376128414786e-09 3.21007692274991e-08 1.52814158229321 0.661538461538462 26.2 26 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.26254383963509e-28 7.73766647300121e-26 1.52272320563266 0.659192825112108 26.2 26 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.93542560510565e-10 6.74712124827149e-09 1.51889191996012 0.657534246575342 26.2 26 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.23436464288249e-09 2.99952913851111e-08 1.51700275090544 0.656716417910448 26.2 26 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.32967618117172e-09 6.37321782000618e-08 1.51592533417894 0.65625 26.2 26 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 9.15130624642075e-05 0.000424179439369926 1.51343613001773 0.655172413793103 26.2 26 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.74139747018614e-07 1.44912783630109e-06 1.51037249412701 0.653846153846154 26.2 26 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000224227258173694 0.000955315534075348 1.51037249412701 0.653846153846154 26.2 26 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000224227258173694 0.000955315534075348 1.51037249412701 0.653846153846154 26.2 26 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000224227258173694 0.000955315534075348 1.51037249412701 0.653846153846154 26.2 26 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.30404496673964e-16 9.76661046142373e-15 1.51037249412701 0.653846153846154 26.2 26 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.16769970529075e-08 1.34002958115221e-07 1.50332126866423 0.650793650793651 26.2 26 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 5.81214725521397e-06 3.40357429801213e-05 1.50148795004391 0.65 26.2 26 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 5.81214725521397e-06 3.40357429801213e-05 1.50148795004391 0.65 26.2 26 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00137091578304692 0.00444376573866917 1.50148795004391 0.65 26.2 26 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00137091578304692 0.00444376573866917 1.50148795004391 0.65 26.2 26 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00137091578304692 0.00444376573866917 1.50148795004391 0.65 26.2 26 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00137091578304692 0.00444376573866917 1.50148795004391 0.65 26.2 26 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00137091578304692 0.00444376573866917 1.50148795004391 0.65 26.2 26 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00137091578304692 0.00444376573866917 1.50148795004391 0.65 26.2 26 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 1.40380959295043e-05 7.62760084824353e-05 1.49836635347417 0.648648648648649 26.2 26 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00343318365376013 0.00981008100261176 1.49469388692154 0.647058823529412 26.2 26 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00343318365376013 0.00981008100261176 1.49469388692154 0.647058823529412 26.2 26 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00343318365376013 0.00981008100261176 1.49469388692154 0.647058823529412 26.2 26 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 9.11688805306248e-07 6.61904678546322e-06 1.49186302728721 0.645833333333333 26.2 26 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.15751328760737e-15 1.60469336009474e-13 1.49031062039097 0.645161290322581 26.2 26 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.15751328760737e-15 1.60469336009474e-13 1.49031062039097 0.645161290322581 26.2 26 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.15751328760737e-15 1.60469336009474e-13 1.49031062039097 0.645161290322581 26.2 26 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 8.25694553757681e-05 0.00038397495097947 1.49031062039097 0.645161290322581 26.2 26 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000201285157928526 0.000878615888749366 1.48498808246101 0.642857142857143 26.2 26 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000201285157928526 0.000878615888749366 1.48498808246101 0.642857142857143 26.2 26 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00870539466697018 0.022121029662676 1.48498808246101 0.642857142857143 26.2 26 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00870539466697018 0.022121029662676 1.48498808246101 0.642857142857143 26.2 26 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00870539466697018 0.022121029662676 1.48498808246101 0.642857142857143 26.2 26 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00870539466697018 0.022121029662676 1.48498808246101 0.642857142857143 26.2 26 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.323752860562e-13 8.47871877071725e-12 1.48347433314147 0.642201834862385 26.2 26 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 9.67020339228154e-09 1.11875605099322e-07 1.48252541565759 0.641791044776119 26.2 26 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000492843341842902 0.00192368694468092 1.47838813542785 0.64 26.2 26 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.68218897715634e-09 4.51703009870127e-08 1.4758214893594 0.638888888888889 26.2 26 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.96961270378696e-06 1.27398130794948e-05 1.47445625208894 0.638297872340426 26.2 26 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.5017089851188e-13 1.5624224111766e-11 1.46998820284019 0.636363636363636 26.2 26 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 4.71761431644184e-06 2.832559144429e-05 1.46998820284019 0.636363636363636 26.2 26 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 4.71761431644184e-06 2.832559144429e-05 1.46998820284019 0.636363636363636 26.2 26 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 4.71761431644184e-06 2.832559144429e-05 1.46998820284019 0.636363636363636 26.2 26 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 7.37767851444931e-05 0.000344211033641356 1.46998820284019 0.636363636363636 26.2 26 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 7.37767851444931e-05 0.000344211033641356 1.46998820284019 0.636363636363636 26.2 26 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00121324652549911 0.00405269907461324 1.46998820284019 0.636363636363636 26.2 26 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00121324652549911 0.00405269907461324 1.46998820284019 0.636363636363636 26.2 26 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0224696324004816 0.0499598232904457 1.46998820284019 0.636363636363636 26.2 26 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0224696324004816 0.0499598232904457 1.46998820284019 0.636363636363636 26.2 26 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0224696324004816 0.0499598232904457 1.46998820284019 0.636363636363636 26.2 26 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0224696324004816 0.0499598232904457 1.46998820284019 0.636363636363636 26.2 26 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0224696324004816 0.0499598232904457 1.46998820284019 0.636363636363636 26.2 26 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 4.92056563925003e-08 4.43827571567634e-07 1.46665489625778 0.634920634920635 26.2 26 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 7.39010824664187e-07 5.50582410207926e-06 1.46594977371151 0.634615384615385 26.2 26 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.2600066240273e-09 1.82958104692943e-08 1.46201358329494 0.632911392405063 26.2 26 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.2600066240273e-09 1.82958104692943e-08 1.46201358329494 0.632911392405063 26.2 26 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.2600066240273e-09 1.82958104692943e-08 1.46201358329494 0.632911392405063 26.2 26 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 4.20798268601818e-06 2.62629796587889e-05 1.4562926605777 0.630434782608696 26.2 26 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000435058156718925 0.00172929541064534 1.4544327721223 0.62962962962963 26.2 26 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.28022851136969e-10 7.25091091866555e-09 1.45045347589215 0.627906976744186 26.2 26 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.00546272784306e-05 5.5889588348464e-05 1.45045347589215 0.627906976744186 26.2 26 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.56901036732285e-06 1.04331857602823e-05 1.4494001327724 0.627450980392157 26.2 26 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.56901036732285e-06 1.04331857602823e-05 1.4494001327724 0.627450980392157 26.2 26 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 3.93055358396906e-08 3.72878516665865e-07 1.44804808040974 0.626865671641791 26.2 26 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 3.93055358396906e-08 3.72878516665865e-07 1.44804808040974 0.626865671641791 26.2 26 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.86346007185505e-07 4.48586219475792e-06 1.44373841350376 0.625 26.2 26 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000157655420775474 0.00069456242651238 1.44373841350376 0.625 26.2 26 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00751823613903008 0.019630183533651 1.44373841350376 0.625 26.2 26 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0596078936118218 0.113398439317677 1.44373841350376 0.625 26.2 26 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00106229054108011 0.00360773136027924 1.44373841350376 0.625 26.2 26 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.96531201156462e-10 1.25940433249516e-08 1.4337815968589 0.620689655172414 26.2 26 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 7.87514552608559e-12 1.69792910357876e-10 1.43304405488521 0.62037037037037 26.2 26 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00260591597680468 0.00761441157082763 1.42998852385134 0.619047619047619 26.2 26 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00260591597680468 0.00761441157082763 1.42998852385134 0.619047619047619 26.2 26 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00260591597680468 0.00761441157082763 1.42998852385134 0.619047619047619 26.2 26 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00260591597680468 0.00761441157082763 1.42998852385134 0.619047619047619 26.2 26 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00260591597680468 0.00761441157082763 1.42998852385134 0.619047619047619 26.2 26 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.13762587474025e-14 5.22206974114638e-13 1.42919716329581 0.618705035971223 26.2 26 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000138041227049167 0.000611939769753785 1.42675325569783 0.617647058823529 26.2 26 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 4.38040563466982e-09 5.2824722187586e-08 1.42591448247285 0.617283950617284 26.2 26 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 4.38040563466982e-09 5.2824722187586e-08 1.42591448247285 0.617283950617284 26.2 26 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00092262907571364 0.00315601243928007 1.42152705329601 0.615384615384615 26.2 26 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00092262907571364 0.00315601243928007 1.42152705329601 0.615384615384615 26.2 26 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00092262907571364 0.00315601243928007 1.42152705329601 0.615384615384615 26.2 26 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0190181529205115 0.0433005305694205 1.42152705329601 0.615384615384615 26.2 26 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0190181529205115 0.0433005305694205 1.42152705329601 0.615384615384615 26.2 26 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0190181529205115 0.0433005305694205 1.42152705329601 0.615384615384615 26.2 26 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.71019068834302e-07 1.43153020559537e-06 1.42152705329601 0.615384615384615 26.2 26 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 6.40655315704057e-08 5.66243797668865e-07 1.41898861212941 0.614285714285714 26.2 26 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.45537130985319e-09 2.05048848903079e-08 1.41748862416732 0.613636363636364 26.2 26 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 4.01859531990601e-07 3.2082845090579e-06 1.41579508937143 0.612903225806452 26.2 26 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.30409039504172e-16 2.66292201397581e-14 1.41486364523368 0.6125 26.2 26 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 6.84352085202555e-06 3.95867080180177e-05 1.41427436424858 0.612244897959184 26.2 26 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.50216946648752e-07 1.27237330405461e-06 1.41357074516189 0.611940298507463 26.2 26 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.39848758367957e-09 4.20525898397915e-08 1.41316512945309 0.611764705882353 26.2 26 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 5.62612730559912e-08 5.00373697241722e-07 1.41165533764812 0.611111111111111 26.2 26 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00642901043518135 0.0169416330541909 1.41165533764812 0.611111111111111 26.2 26 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00642901043518135 0.0169416330541909 1.41165533764812 0.611111111111111 26.2 26 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.82538922788635e-10 7.98433589683985e-09 1.4103044712963 0.610526315789474 26.2 26 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.82538922788635e-10 7.98433589683985e-09 1.4103044712963 0.610526315789474 26.2 26 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 9.43748190975409e-07 6.78259432201014e-06 1.40948021386129 0.610169491525424 26.2 26 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 9.43748190975409e-07 6.78259432201014e-06 1.40948021386129 0.610169491525424 26.2 26 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 4.39456982478879e-05 0.000214895974593624 1.40852528146708 0.609756097560976 26.2 26 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.66492593762446e-20 2.52812640615974e-18 1.40798870040747 0.60952380952381 26.2 26 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.98299380982366e-09 3.85890926489006e-08 1.40723008580596 0.609195402298851 26.2 26 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.98299380982366e-09 3.85890926489006e-08 1.40723008580596 0.609195402298851 26.2 26 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.6161115394727e-05 8.64558917544984e-05 1.40607567228192 0.608695652173913 26.2 26 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00224110466260805 0.00669977297246061 1.40607567228192 0.608695652173913 26.2 26 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.92795195415926e-08 4.43827571567634e-07 1.40471845638203 0.608108108108108 26.2 26 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.92795195415926e-08 4.43827571567634e-07 1.40471845638203 0.608108108108108 26.2 26 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 5.97137083058019e-06 3.46826967016963e-05 1.40410637862326 0.607843137254902 26.2 26 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.84876936654903e-08 1.99302940045399e-07 1.40353303996315 0.607594936708861 26.2 26 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.000796343700304086 0.0027638953305676 1.40248874454651 0.607142857142857 26.2 26 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 8.24093261963364e-07 6.0447665555354e-06 1.40113629638397 0.60655737704918 26.2 26 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000286699475592366 0.0011623172472021 1.3999887646097 0.606060606060606 26.2 26 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000104203361746998 0.000472233706261076 1.39814667412995 0.605263157894737 26.2 26 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 3.81471641558224e-05 0.00018848407845047 1.39673297678503 0.604651162790698 26.2 26 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.40437907395629e-05 7.62760084824353e-05 1.3956137997203 0.604166666666667 26.2 26 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.61811660215859e-11 9.52402887662561e-10 1.39431313448291 0.603603603603604 26.2 26 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.92764910905414e-06 1.25253181834888e-05 1.39395433027949 0.603448275862069 26.2 26 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.92764910905414e-06 1.25253181834888e-05 1.39395433027949 0.603448275862069 26.2 26 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.48994510214388e-17 1.96843993352819e-15 1.39352142520797 0.603260869565217 26.2 26 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.17652754753437e-07 5.37484142112706e-06 1.3933221514449 0.603174603174603 26.2 26 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.00191631554008e-07 8.69345681105809e-07 1.39231759329677 0.602739726027397 26.2 26 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.99290273975622e-09 2.700857713022e-08 1.39095657903158 0.602150537634409 26.2 26 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.1383605206169e-20 2.17349072916989e-18 1.38806060921617 0.600896860986547 26.2 26 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0488977112176001 0.0954477956963579 1.38598887696361 0.6 26.2 26 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0488977112176001 0.0954477956963579 1.38598887696361 0.6 26.2 26 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0488977112176001 0.0954477956963579 1.38598887696361 0.6 26.2 26 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0488977112176001 0.0954477956963579 1.38598887696361 0.6 26.2 26 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0488977112176001 0.0954477956963579 1.38598887696361 0.6 26.2 26 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 6.54053664822332e-10 1.0457509719575e-08 1.38598887696361 0.6 26.2 26 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.73593150329661e-09 2.37602552693932e-08 1.38598887696361 0.6 26.2 26 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.67326769815848e-06 1.09726264261729e-05 1.38598887696361 0.6 26.2 26 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 4.50399637188108e-06 2.7389687338405e-05 1.38598887696361 0.6 26.2 26 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.50399637188108e-06 2.7389687338405e-05 1.38598887696361 0.6 26.2 26 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 4.50399637188108e-06 2.7389687338405e-05 1.38598887696361 0.6 26.2 26 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 4.50399637188108e-06 2.7389687338405e-05 1.38598887696361 0.6 26.2 26 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 4.50399637188108e-06 2.7389687338405e-05 1.38598887696361 0.6 26.2 26 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.21656627771636e-05 6.73608487622715e-05 1.38598887696361 0.6 26.2 26 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 3.29997058469442e-05 0.000166519792270218 1.38598887696361 0.6 26.2 26 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000247009860080077 0.00103685849821224 1.38598887696361 0.6 26.2 26 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000247009860080077 0.00103685849821224 1.38598887696361 0.6 26.2 26 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000683980894444176 0.00259547950078417 1.38598887696361 0.6 26.2 26 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000683980894444176 0.00259547950078417 1.38598887696361 0.6 26.2 26 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00191646133993593 0.00576559088103347 1.38598887696361 0.6 26.2 26 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00191646133993593 0.00576559088103347 1.38598887696361 0.6 26.2 26 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0159725793806398 0.0371996406851889 1.38598887696361 0.6 26.2 26 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0159725793806398 0.0371996406851889 1.38598887696361 0.6 26.2 26 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0159725793806398 0.0371996406851889 1.38598887696361 0.6 26.2 26 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.61365993347268e-24 4.64904760666452e-22 1.38429036118301 0.599264705882353 26.2 26 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.83740335011231e-08 3.03580824602242e-07 1.38035477583774 0.597560975609756 26.2 26 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.1213132506565e-14 5.22206974114638e-13 1.38017760284636 0.59748427672956 26.2 26 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.80471811607989e-12 9.49844540207313e-11 1.37882614374932 0.596899224806202 26.2 26 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.04289918611381e-11 1.43172079169142e-09 1.37788367885271 0.596491228070175 26.2 26 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.252095728921e-06 8.73398148164008e-06 1.37155149282857 0.59375 26.2 26 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.252095728921e-06 8.73398148164008e-06 1.37155149282857 0.59375 26.2 26 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 9.18436893019076e-16 5.4455654115256e-14 1.37032798569848 0.593220338983051 26.2 26 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 9.05711090829171e-06 5.07412158366107e-05 1.36887790317393 0.592592592592593 26.2 26 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 9.05711090829171e-06 5.07412158366107e-05 1.36887790317393 0.592592592592593 26.2 26 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00163182313970595 0.00512601396865688 1.36887790317393 0.592592592592593 26.2 26 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00163182313970595 0.00512601396865688 1.36887790317393 0.592592592592593 26.2 26 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00163182313970595 0.00512601396865688 1.36887790317393 0.592592592592593 26.2 26 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.44364059605077e-14 1.80611836912785e-12 1.36833296770292 0.592356687898089 26.2 26 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.51125097696436e-07 1.27249120723094e-06 1.36775218121409 0.592105263157895 26.2 26 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.61019329705315e-09 3.43917135343207e-08 1.36713188544029 0.591836734693878 26.2 26 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 4.03571979705808e-07 3.2082845090579e-06 1.36646790686553 0.591549295774648 26.2 26 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 2.89607888627946e-06 1.85636047530436e-05 1.36326774783306 0.590163934426229 26.2 26 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.89607888627946e-06 1.85636047530436e-05 1.36326774783306 0.590163934426229 26.2 26 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 7.78845993419711e-06 4.43319139454499e-05 1.36123907558926 0.589285714285714 26.2 26 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0133540254037015 0.0316185992503614 1.35881262447412 0.588235294117647 26.2 26 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0133540254037015 0.0316185992503614 1.35881262447412 0.588235294117647 26.2 26 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0133540254037015 0.0316185992503614 1.35881262447412 0.588235294117647 26.2 26 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 4.22203254387895e-08 3.9267662156469e-07 1.35881262447412 0.588235294117647 26.2 26 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 4.22203254387895e-08 3.9267662156469e-07 1.35881262447412 0.588235294117647 26.2 26 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 4.22203254387895e-08 3.9267662156469e-07 1.35881262447412 0.588235294117647 26.2 26 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 5.69282291211473e-05 0.000270029566797975 1.35585868398614 0.58695652173913 26.2 26 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 5.69282291211473e-05 0.000270029566797975 1.35585868398614 0.58695652173913 26.2 26 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.9937243483335e-07 2.42049417481737e-06 1.35518912414219 0.586666666666667 26.2 26 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00138487162615369 0.00444847025737405 1.35412706370007 0.586206896551724 26.2 26 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00138487162615369 0.00444847025737405 1.35412706370007 0.586206896551724 26.2 26 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00138487162615369 0.00444847025737405 1.35412706370007 0.586206896551724 26.2 26 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00138487162615369 0.00444847025737405 1.35412706370007 0.586206896551724 26.2 26 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.80007464301072e-05 9.52232794425375e-05 1.35112123226012 0.584905660377358 26.2 26 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.80007464301072e-05 9.52232794425375e-05 1.35112123226012 0.584905660377358 26.2 26 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 5.7274362975837e-06 3.38180159811685e-05 1.34748918593684 0.583333333333333 26.2 26 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 4.86469310320798e-05 0.000233079403564476 1.34748918593684 0.583333333333333 26.2 26 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.040030632161996 0.0804570474103395 1.34748918593684 0.583333333333333 26.2 26 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.040030632161996 0.0804570474103395 1.34748918593684 0.583333333333333 26.2 26 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.040030632161996 0.0804570474103395 1.34748918593684 0.583333333333333 26.2 26 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.040030632161996 0.0804570474103395 1.34748918593684 0.583333333333333 26.2 26 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.040030632161996 0.0804570474103395 1.34748918593684 0.583333333333333 26.2 26 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.85811016220643e-07 5.19100572384029e-06 1.34748918593684 0.583333333333333 26.2 26 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.85811016220643e-07 5.19100572384029e-06 1.34748918593684 0.583333333333333 26.2 26 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 4.75330595456802e-21 6.14904943031845e-19 1.34527656001576 0.582375478927203 26.2 26 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.53918789589497e-05 8.26514858814546e-05 1.34398921402532 0.581818181818182 26.2 26 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 7.59115109301119e-41 3.60073600178497e-38 1.34382951948943 0.581749049429658 26.2 26 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.69379600267725e-14 1.12743285641463e-12 1.34301247767791 0.581395348837209 26.2 26 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 7.12837095692295e-08 6.26152584672924e-07 1.34301247767791 0.581395348837209 26.2 26 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 9.25502152814073e-21 1.09749130287869e-18 1.34156615654811 0.580769230769231 26.2 26 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 4.89972770714219e-06 2.91728557626081e-05 1.34127955835188 0.580645161290323 26.2 26 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00117225751024083 0.00394355186069196 1.34127955835188 0.580645161290323 26.2 26 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 7.47536589391029e-09 8.79127741077219e-08 1.33978924773149 0.58 26.2 26 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.99140295349294e-10 5.19117854002494e-09 1.33940101555306 0.579831932773109 26.2 26 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 6.85543017881619e-33 1.95105542889109e-30 1.33935544839597 0.57981220657277 26.2 26 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.56721827489883e-06 1.04331857602823e-05 1.33911968788754 0.579710144927536 26.2 26 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.56721827489883e-06 1.04331857602823e-05 1.33911968788754 0.579710144927536 26.2 26 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 6.51328848628373e-15 3.19600328137302e-13 1.33802204879911 0.579234972677596 26.2 26 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0111342768656369 0.0274594037778185 1.33735768829822 0.578947368421053 26.2 26 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0111342768656369 0.0274594037778185 1.33735768829822 0.578947368421053 26.2 26 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.56699116886204e-10 4.50966473245763e-09 1.3363529116729 0.578512396694215 26.2 26 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.56699116886204e-10 4.50966473245763e-09 1.3363529116729 0.578512396694215 26.2 26 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 5.23382213380953e-08 4.68410622415784e-07 1.33465595559458 0.577777777777778 26.2 26 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0032716871547845 0.00940527438638049 1.33268161246501 0.576923076923077 26.2 26 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0032716871547845 0.00940527438638049 1.33268161246501 0.576923076923077 26.2 26 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0032716871547845 0.00940527438638049 1.33268161246501 0.576923076923077 26.2 26 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.29557694455526e-22 2.04845110233571e-20 1.33237838570449 0.57679180887372 26.2 26 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.0114462732056e-13 3.88996769397721e-12 1.33163637198464 0.576470588235294 26.2 26 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.14368173365509e-06 8.09681147756813e-06 1.3290304299651 0.575342465753425 26.2 26 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000305346150351329 0.00122396499140829 1.32823934042346 0.575 26.2 26 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.9475040399545e-13 7.29289012856646e-12 1.3258473477857 0.57396449704142 26.2 26 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.07967968234097e-14 8.96783087264001e-13 1.32539919928214 0.573770491803279 26.2 26 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000258347513555961 0.00108126032879451 1.31998940663201 0.571428571428571 26.2 26 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000835146458086085 0.00289151681230292 1.31998940663201 0.571428571428571 26.2 26 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00274579572557509 0.00797401493365992 1.31998940663201 0.571428571428571 26.2 26 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00274579572557509 0.00797401493365992 1.31998940663201 0.571428571428571 26.2 26 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00926806462385796 0.0235088341528518 1.31998940663201 0.571428571428571 26.2 26 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0327684972585665 0.0673837739869076 1.31998940663201 0.571428571428571 26.2 26 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0327684972585665 0.0673837739869076 1.31998940663201 0.571428571428571 26.2 26 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0327684972585665 0.0673837739869076 1.31998940663201 0.571428571428571 26.2 26 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0327684972585665 0.0673837739869076 1.31998940663201 0.571428571428571 26.2 26 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 9.77083878816364e-13 3.23346595245508e-11 1.3179648830022 0.570552147239264 26.2 26 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 7.7140712811958e-09 8.99764215831281e-08 1.31690531923333 0.570093457943925 26.2 26 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.72751781061522e-08 1.92051394101989e-07 1.31047025225726 0.567307692307692 26.2 26 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.04752732068007e-10 8.25589813485947e-09 1.30959578925695 0.566929133858268 26.2 26 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.2699115146253e-11 2.65747659604677e-10 1.30696319538235 0.565789473684211 26.2 26 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.59073006286086e-06 1.05284133927954e-05 1.30696319538235 0.565789473684211 26.2 26 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.53717657847935e-08 4.16542082011362e-07 1.30665618030239 0.565656565656566 26.2 26 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.32094583786161e-09 1.89869285583542e-08 1.30646492500668 0.565573770491803 26.2 26 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000184280497253933 0.00080935539380354 1.30564169569035 0.565217391304348 26.2 26 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00770692808459767 0.0200860048798214 1.30564169569035 0.565217391304348 26.2 26 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.01579253818627e-10 1.87723737901177e-09 1.30348953904911 0.564285714285714 26.2 26 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.94377628851115e-26 8.01713379793052e-24 1.30322483529109 0.564171122994652 26.2 26 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0268424492627095 0.0577863922856818 1.29936457215338 0.5625 26.2 26 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0268424492627095 0.0577863922856818 1.29936457215338 0.5625 26.2 26 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0268424492627095 0.0577863922856818 1.29936457215338 0.5625 26.2 26 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0268424492627095 0.0577863922856818 1.29936457215338 0.5625 26.2 26 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.000497481936502165 0.00192368694468092 1.29584325894971 0.560975609756098 26.2 26 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.000497481936502165 0.00192368694468092 1.29584325894971 0.560975609756098 26.2 26 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.000497481936502165 0.00192368694468092 1.29584325894971 0.560975609756098 26.2 26 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.000497481936502165 0.00192368694468092 1.29584325894971 0.560975609756098 26.2 26 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00640505927814324 0.0169412627375424 1.29358961849937 0.56 26.2 26 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00640505927814324 0.0169412627375424 1.29358961849937 0.56 26.2 26 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 8.21700351441558e-07 6.0447665555354e-06 1.29248962732717 0.55952380952381 26.2 26 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 8.21700351441558e-07 6.0447665555354e-06 1.29248962732717 0.55952380952381 26.2 26 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.49376652028866e-05 0.000175057385858126 1.29202352937285 0.559322033898305 26.2 26 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 3.49376652028866e-05 0.000175057385858126 1.29202352937285 0.559322033898305 26.2 26 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.90388508116189e-15 1.08369138819735e-13 1.29148963535245 0.559090909090909 26.2 26 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00161242962573431 0.0050988607942665 1.29087199325042 0.558823529411765 26.2 26 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00161242962573431 0.0050988607942665 1.29087199325042 0.558823529411765 26.2 26 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00161242962573431 0.0050988607942665 1.29087199325042 0.558823529411765 26.2 26 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 6.9563194851112e-07 5.23748287159431e-06 1.2892919785708 0.558139534883721 26.2 26 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.27792298804473e-14 5.68276378746142e-13 1.28698967146621 0.557142857142857 26.2 26 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.37240963967228e-09 4.20525898397915e-08 1.28539291008722 0.556451612903226 26.2 26 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 9.32860058923629e-10 1.42737619768637e-08 1.28525284329958 0.556390977443609 26.2 26 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00134841447679504 0.00444376573866917 1.28332303422556 0.555555555555556 26.2 26 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0220102941143516 0.0495356898490738 1.28332303422556 0.555555555555556 26.2 26 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0220102941143516 0.0495356898490738 1.28332303422556 0.555555555555556 26.2 26 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0220102941143516 0.0495356898490738 1.28332303422556 0.555555555555556 26.2 26 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0220102941143516 0.0495356898490738 1.28332303422556 0.555555555555556 26.2 26 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.101393720491541 0.170547593687309 1.28332303422556 0.555555555555556 26.2 26 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 3.17635361521565e-08 3.09585698250128e-07 1.28098971961788 0.554545454545455 26.2 26 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 7.41504209423538e-09 8.79127741077219e-08 1.27908064402977 0.553719008264463 26.2 26 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.30055777200232e-06 8.98395004640438e-06 1.27728386700568 0.552941176470588 26.2 26 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.30055777200232e-06 8.98395004640438e-06 1.27728386700568 0.552941176470588 26.2 26 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 6.5665959569272e-05 0.000309412783003557 1.27447253054125 0.551724137931034 26.2 26 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 6.5665959569272e-05 0.000309412783003557 1.27447253054125 0.551724137931034 26.2 26 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 4.02760672535977e-06 2.52479487673434e-05 1.27345131857767 0.551282051282051 26.2 26 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.48570556712937e-05 8.00817811373142e-05 1.27216370349316 0.550724637681159 26.2 26 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.48570556712937e-05 8.00817811373142e-05 1.27216370349316 0.550724637681159 26.2 26 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 8.88558634248699e-10 1.37436840927815e-08 1.27048980388331 0.55 26.2 26 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0180681321527371 0.0416709109454537 1.27048980388331 0.55 26.2 26 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0180681321527371 0.0416709109454537 1.27048980388331 0.55 26.2 26 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0180681321527371 0.0416709109454537 1.27048980388331 0.55 26.2 26 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.90981689178387e-16 2.52894065318566e-14 1.26498984802234 0.547619047619048 26.2 26 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.90981689178387e-16 2.52894065318566e-14 1.26498984802234 0.547619047619048 26.2 26 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.90981689178387e-16 2.52894065318566e-14 1.26498984802234 0.547619047619048 26.2 26 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.000786960448489678 0.00275017061107082 1.26498984802234 0.547619047619048 26.2 26 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.63387394901318e-09 2.27941434259388e-08 1.2630114466335 0.546762589928058 26.2 26 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.00305125282305376 0.00882506660001118 1.25998988814873 0.545454545454545 26.2 26 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00305125282305376 0.00882506660001118 1.25998988814873 0.545454545454545 26.2 26 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.014848682618059 0.0348674510981814 1.25998988814873 0.545454545454545 26.2 26 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.014848682618059 0.0348674510981814 1.25998988814873 0.545454545454545 26.2 26 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.014848682618059 0.0348674510981814 1.25998988814873 0.545454545454545 26.2 26 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.014848682618059 0.0348674510981814 1.25998988814873 0.545454545454545 26.2 26 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0806114057981424 0.145941514568393 1.25998988814873 0.545454545454545 26.2 26 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.94516664277898e-10 3.50376219325884e-09 1.25733168163365 0.544303797468354 26.2 26 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.74725277851177e-05 0.000139619310850794 1.25690167763856 0.544117647058823 26.2 26 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.27780732520128e-08 1.45465585900913e-07 1.25502929803791 0.543307086614173 26.2 26 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 5.26405525878701e-06 3.12114609718913e-05 1.2548047445761 0.54320987654321 26.2 26 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 2.30622828207357e-05 0.000119772366620098 1.25398993630041 0.542857142857143 26.2 26 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00253545338731656 0.00748537379699474 1.25398993630041 0.542857142857143 26.2 26 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.02100263190824e-13 1.07472168630136e-11 1.25398993630041 0.542857142857143 26.2 26 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 4.42460736257872e-06 2.7389687338405e-05 1.25239958761772 0.542168674698795 26.2 26 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000458600633989427 0.00179776501974368 1.25123995836992 0.541666666666667 26.2 26 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0122161360367846 0.029216069882932 1.25123995836992 0.541666666666667 26.2 26 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0122161360367846 0.029216069882932 1.25123995836992 0.541666666666667 26.2 26 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.93566814671271e-05 0.000101640434419638 1.25123995836992 0.541666666666667 26.2 26 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.27555715384332e-08 3.17082845572724e-07 1.2496621021803 0.540983606557377 26.2 26 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000383013198304983 0.00152668846271146 1.24738998926725 0.54 26.2 26 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000383013198304983 0.00152668846271146 1.24738998926725 0.54 26.2 26 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00175174456199341 0.00535422868196106 1.24383617163401 0.538461538461538 26.2 26 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00175174456199341 0.00535422868196106 1.24383617163401 0.538461538461538 26.2 26 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0645451912770613 0.12181406788761 1.24383617163401 0.538461538461538 26.2 26 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0645451912770613 0.12181406788761 1.24383617163401 0.538461538461538 26.2 26 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.38517844259124e-08 1.56437216175185e-07 1.24249002859111 0.537878787878788 26.2 26 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.22481110755431e-49 4.58890620604978e-46 1.24122307043309 0.537330316742081 26.2 26 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000267159740534009 0.00111486308146597 1.24054559975138 0.537037037037037 26.2 26 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 8.04681832565287e-06 4.54389780849367e-05 1.23950224769103 0.536585365853659 26.2 26 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00145655110846588 0.00466818069222285 1.23950224769103 0.536585365853659 26.2 26 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.54557867974728e-07 2.06991912073164e-06 1.23899005667959 0.536363636363636 26.2 26 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00829350345985304 0.021351687815169 1.23749006871751 0.535714285714286 26.2 26 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.15346024438321e-09 1.74614247633756e-08 1.23695781492451 0.535483870967742 26.2 26 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.09673490864701e-06 7.80326887502348e-06 1.2366567420719 0.535353535353535 26.2 26 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.00121139223312786 0.00405269907461324 1.23557147946368 0.534883720930233 26.2 26 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.74710708774887e-06 2.83829133859943e-05 1.2337400988123 0.534090909090909 26.2 26 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00684290287599781 0.017965776370009 1.23199011285654 0.533333333333333 26.2 26 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00684290287599781 0.017965776370009 1.23199011285654 0.533333333333333 26.2 26 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0519638319761968 0.100741870438867 1.23199011285654 0.533333333333333 26.2 26 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0519638319761968 0.100741870438867 1.23199011285654 0.533333333333333 26.2 26 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0519638319761968 0.100741870438867 1.23199011285654 0.533333333333333 26.2 26 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.44760234443393e-07 4.28283874924281e-06 1.23055087207049 0.532710280373832 26.2 26 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.3381427166673e-06 2.11118981591892e-05 1.23031621324668 0.532608695652174 26.2 26 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 4.57256559652407e-07 3.6148671354743e-06 1.22916444746008 0.532110091743119 26.2 26 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.73651900774202e-09 2.37602552693932e-08 1.22902859816217 0.532051282051282 26.2 26 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00565075298193252 0.0150580926840636 1.22717765147819 0.53125 26.2 26 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000697903698637901 0.00260187383686157 1.22570444901543 0.530612244897959 26.2 26 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000697903698637901 0.00260187383686157 1.22570444901543 0.530612244897959 26.2 26 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.64986594003739e-06 1.08692557068204e-05 1.22429017465119 0.53 26.2 26 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000580997246106113 0.00224053951547154 1.22293136202671 0.529411764705882 26.2 26 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00466992892003816 0.012609694218623 1.22293136202671 0.529411764705882 26.2 26 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00466992892003816 0.012609694218623 1.22293136202671 0.529411764705882 26.2 26 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00466992892003816 0.012609694218623 1.22293136202671 0.529411764705882 26.2 26 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.0420169261040935 0.0836224976868882 1.22293136202671 0.529411764705882 26.2 26 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0420169261040935 0.0836224976868882 1.22293136202671 0.529411764705882 26.2 26 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0420169261040935 0.0836224976868882 1.22293136202671 0.529411764705882 26.2 26 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0420169261040935 0.0836224976868882 1.22293136202671 0.529411764705882 26.2 26 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.34047055053625e-07 1.1422093373731e-06 1.2207219106048 0.528455284552846 26.2 26 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 7.12194447932674e-06 4.07009116228191e-05 1.21987785051104 0.528089887640449 26.2 26 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00386214393437001 0.0109478701565907 1.21915688251428 0.527777777777778 26.2 26 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.233637726051e-09 4.07209423377927e-08 1.21274026734316 0.525 26.2 26 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00264680428077961 0.00771803789251923 1.21274026734316 0.525 26.2 26 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00219310083443969 0.00657006839454249 1.20999028941267 0.523809523809524 26.2 26 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00219310083443969 0.00657006839454249 1.20999028941267 0.523809523809524 26.2 26 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0277482064345042 0.0586711705145609 1.20999028941267 0.523809523809524 26.2 26 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0226396875636531 0.0501030721665293 1.20520771909879 0.521739130434783 26.2 26 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0226396875636531 0.0501030721665293 1.20520771909879 0.521739130434783 26.2 26 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0226396875636531 0.0501030721665293 1.20520771909879 0.521739130434783 26.2 26 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.715959069174e-38 1.32195243885865e-35 1.2037931560482 0.52112676056338 26.2 26 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00125150268974369 0.00417069865926292 1.20311534458646 0.520833333333333 26.2 26 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0185114691919795 0.0424183907571447 1.20119036003513 0.52 26.2 26 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0185114691919795 0.0424183907571447 1.20119036003513 0.52 26.2 26 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0185114691919795 0.0424183907571447 1.20119036003513 0.52 26.2 26 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0185114691919795 0.0424183907571447 1.20119036003513 0.52 26.2 26 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.000863001859151035 0.00297349066724436 1.19941345121851 0.519230769230769 26.2 26 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.000863001859151035 0.00297349066724436 1.19941345121851 0.519230769230769 26.2 26 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0151643524588316 0.0355500387955804 1.19776816527719 0.518518518518518 26.2 26 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.1771463820339e-05 0.000160892501837517 1.1967373837236 0.518072289156627 26.2 26 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 2.65308297852945e-05 0.000135316741162989 1.19575510953723 0.517647058823529 26.2 26 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 2.65308297852945e-05 0.000135316741162989 1.19575510953723 0.517647058823529 26.2 26 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 2.65308297852945e-05 0.000135316741162989 1.19575510953723 0.517647058823529 26.2 26 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 2.65308297852945e-05 0.000135316741162989 1.19575510953723 0.517647058823529 26.2 26 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 2.65308297852945e-05 0.000135316741162989 1.19575510953723 0.517647058823529 26.2 26 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.010224614537501 0.0257060538637172 1.19224849631278 0.516129032258065 26.2 26 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0084127219007412 0.0215311209797747 1.18999044991825 0.515151515151515 26.2 26 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00571453091278072 0.0151712266583712 1.18620669650038 0.513513513513513 26.2 26 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00571453091278072 0.0151712266583712 1.18620669650038 0.513513513513513 26.2 26 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.21573405905285e-09 1.82104164845495e-08 1.18587283590469 0.513368983957219 26.2 26 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 9.54208864400252e-05 0.000439430166356491 1.18538522371887 0.513157894736842 26.2 26 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.46389440958671e-08 1.64025334239518e-07 1.18316123643235 0.51219512195122 26.2 26 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 8.80880488229895e-07 6.4281688961597e-06 1.18316123643235 0.51219512195122 26.2 26 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00389657011170902 0.0110234975526082 1.18316123643235 0.51219512195122 26.2 26 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 5.10105402559405e-12 1.2515172204173e-10 1.17818331575889 0.51004016064257 26.2 26 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00104285626239054 0.00355020206072186 1.17599056227215 0.509090909090909 26.2 26 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.70362272784606e-06 2.3319713016482e-05 1.17561556528163 0.508928571428571 26.2 26 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 9.53332921439051e-05 0.000439430166356491 1.16924987562773 0.506172839506173 26.2 26 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.60369031222858e-07 2.8972041323736e-06 1.16306758906037 0.503496503496504 26.2 26 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000588019908097372 0.00226149278168259 1.15499073080301 0.5 26.2 26 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00382274336380096 0.0109013302739254 1.15499073080301 0.5 26.2 26 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00560003938897833 0.0149509494381166 1.15499073080301 0.5 26.2 26 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00823282467499925 0.021351687815169 1.15499073080301 0.5 26.2 26 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0121555148814442 0.0291691360477152 1.15499073080301 0.5 26.2 26 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0220352014578101 0.0495356898490738 1.15499073080301 0.5 26.2 26 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.0269622782952306 0.0578692639730213 1.15499073080301 0.5 26.2 26 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0269622782952306 0.0578692639730213 1.15499073080301 0.5 26.2 26 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0330632390905216 0.0677939326020349 1.15499073080301 0.5 26.2 26 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0330632390905216 0.0677939326020349 1.15499073080301 0.5 26.2 26 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0406477302509495 0.0814672114747903 1.15499073080301 0.5 26.2 26 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0406477302509495 0.0814672114747903 1.15499073080301 0.5 26.2 26 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0501213832953322 0.097702367711312 1.15499073080301 0.5 26.2 26 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0770852146896844 0.141904606084632 1.15499073080301 0.5 26.2 26 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0770852146896844 0.141904606084632 1.15499073080301 0.5 26.2 26 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0770852146896844 0.141904606084632 1.15499073080301 0.5 26.2 26 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0963218852955561 0.163954596621503 1.15499073080301 0.5 26.2 26 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.121192179434289 0.20123275535005 1.15499073080301 0.5 26.2 26 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.121192179434289 0.20123275535005 1.15499073080301 0.5 26.2 26 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.121192179434289 0.20123275535005 1.15499073080301 0.5 26.2 26 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.121192179434289 0.20123275535005 1.15499073080301 0.5 26.2 26 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.153889729765483 0.246604825964282 1.15499073080301 0.5 26.2 26 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0620235580938353 0.117522667333592 1.154990730803 0.5 26.2 26 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0620235580938353 0.117522667333592 1.154990730803 0.5 26.2 26 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0620235580938353 0.117522667333592 1.154990730803 0.5 26.2 26 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.01880570299801e-06 7.285228720433e-06 1.14679930718029 0.49645390070922 26.2 26 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 3.78904729558799e-08 3.64311777136602e-07 1.13092842391128 0.489583333333333 26.2 26 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00537138881994188 0.0143945127886578 1.13041645993486 0.48936170212766 26.2 26 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00953921841767407 0.0241535726127228 1.12682022517366 0.48780487804878 26.2 26 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0115730902346457 0.0281994989792822 1.12537558385934 0.487179487179487 26.2 26 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.62233260423294e-19 1.44286205988967e-17 1.12471007493926 0.48689138576779 26.2 26 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000790456626794073 0.00275017061107082 1.12290765494737 0.486111111111111 26.2 26 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000950292392436105 0.00324284430320522 1.1219909956372 0.485714285714286 26.2 26 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0170907594233841 0.0396093658949113 1.1219909956372 0.485714285714286 26.2 26 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0208085976858489 0.0472258923556028 1.11999101168776 0.484848484848485 26.2 26 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0253723465780405 0.0557173598465303 1.11773296529323 0.483870967741935 26.2 26 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0379174951433153 0.0769708924235915 1.11221329632882 0.481481481481481 26.2 26 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0379174951433153 0.0769708924235915 1.11221329632882 0.481481481481481 26.2 26 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0379174951433153 0.0769708924235915 1.11221329632882 0.481481481481481 26.2 26 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0379174951433153 0.0769708924235915 1.11221329632882 0.481481481481481 26.2 26 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0379174951433153 0.0769708924235915 1.11221329632882 0.481481481481481 26.2 26 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.27907419579197e-05 7.02750031124316e-05 1.1109071151235 0.480916030534351 26.2 26 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.27907419579197e-05 7.02750031124316e-05 1.1109071151235 0.480916030534351 26.2 26 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00507408747214618 0.0136491993815955 1.11056801038751 0.480769230769231 26.2 26 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0464956420737912 0.0916389178268766 1.10879110157088 0.48 26.2 26 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0464956420737912 0.0916389178268766 1.10879110157088 0.48 26.2 26 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0571551027143045 0.110505042340293 1.10477374250722 0.478260869565217 26.2 26 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.81649618542767e-21 5.43087407186357e-19 1.10289939146663 0.477449455676516 26.2 26 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0704606349869941 0.132102086411716 1.09999117219334 0.476190476190476 26.2 26 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0704606349869941 0.132102086411716 1.09999117219334 0.476190476190476 26.2 26 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0159036274026917 0.0371996406851889 1.09724119426286 0.475 26.2 26 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00473980506864806 0.0127741337361481 1.09420174497127 0.473684210526316 26.2 26 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0192960871864037 0.043863150265579 1.09420174497127 0.473684210526316 26.2 26 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0871594784266561 0.154071972423766 1.09420174497127 0.473684210526316 26.2 26 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0871594784266561 0.154071972423766 1.09420174497127 0.473684210526316 26.2 26 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.56976883599131e-18 3.82516532565625e-16 1.09228545469986 0.472854640980736 26.2 26 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0234371096666758 0.0517872780367696 1.09082457909173 0.472222222222222 26.2 26 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.00688574486337427 0.0180117921701867 1.08961389698397 0.471698113207547 26.2 26 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00688574486337427 0.0180117921701867 1.08961389698397 0.471698113207547 26.2 26 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 5.94067202986189e-06 3.46458045020224e-05 1.08878107107544 0.471337579617834 26.2 26 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.000209607819912491 0.000912146567998395 1.08835665017976 0.471153846153846 26.2 26 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 7.08254596459091e-06 4.06389633371487e-05 1.08792675288541 0.470967741935484 26.2 26 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0285002268453197 0.0600827004457629 1.0870500995793 0.470588235294118 26.2 26 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0285002268453197 0.0600827004457629 1.0870500995793 0.470588235294118 26.2 26 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.108257026765765 0.181234998926687 1.0870500995793 0.470588235294118 26.2 26 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.108257026765765 0.181234998926687 1.0870500995793 0.470588235294118 26.2 26 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 6.73716715900708e-46 4.79349443363354e-43 1.08564654877287 0.469980632666236 26.2 26 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00113398993313934 0.00383293984526669 1.08369500667936 0.469135802469136 26.2 26 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00113398993313934 0.00383293984526669 1.08369500667936 0.469135802469136 26.2 26 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0013589450897038 0.00444376573866917 1.08189005163826 0.468354430379747 26.2 26 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00439023756483307 0.0121542958263764 1.08047519978346 0.467741935483871 26.2 26 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000233283925528682 0.000990934406051684 1.07943058953552 0.467289719626168 26.2 26 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.014626215109789 0.0345732626266274 1.07799134874947 0.466666666666667 26.2 26 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0423151673392074 0.0840984401168884 1.07799134874947 0.466666666666667 26.2 26 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.135135181949995 0.219267233654325 1.07799134874947 0.466666666666667 26.2 26 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.135135181949995 0.219267233654325 1.07799134874947 0.466666666666667 26.2 26 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.135135181949995 0.219267233654325 1.07799134874947 0.466666666666667 26.2 26 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.135135181949995 0.219267233654325 1.07799134874947 0.466666666666667 26.2 26 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.051682149670753 0.100606975350864 1.0724913928885 0.464285714285714 26.2 26 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.021400162435207 0.0484911323969737 1.07047921391498 0.463414634146341 26.2 26 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.97087968424575e-10 9.65518385304738e-09 1.06996073835125 0.46319018404908 26.2 26 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.169746740711912 0.265147762934195 1.066145289972 0.461538461538462 26.2 26 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.169746740711912 0.265147762934195 1.066145289972 0.461538461538462 26.2 26 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.169746740711912 0.265147762934195 1.066145289972 0.461538461538462 26.2 26 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.169746740711912 0.265147762934195 1.066145289972 0.461538461538462 26.2 26 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0775405257805822 0.142190938383722 1.05874150323609 0.458333333333333 26.2 26 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0775405257805822 0.142190938383722 1.05874150323609 0.458333333333333 26.2 26 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0775405257805822 0.142190938383722 1.05874150323609 0.458333333333333 26.2 26 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00442943362962079 0.0122168675651952 1.0559915253056 0.457142857142857 26.2 26 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.214954999738266 0.326163475249291 1.04999157345728 0.454545454545455 26.2 26 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.214954999738266 0.326163475249291 1.04999157345728 0.454545454545455 26.2 26 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.214954999738266 0.326163475249291 1.04999157345728 0.454545454545455 26.2 26 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.214954999738266 0.326163475249291 1.04999157345728 0.454545454545455 26.2 26 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.214954999738266 0.326163475249291 1.04999157345728 0.454545454545455 26.2 26 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.214954999738266 0.326163475249291 1.04999157345728 0.454545454545455 26.2 26 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.214954999738266 0.326163475249291 1.04999157345728 0.454545454545455 26.2 26 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.07976925646133e-07 9.2560942888221e-07 1.04241040686192 0.451263537906137 26.2 26 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.117463374443194 0.195955898983195 1.0394916577227 0.45 26.2 26 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.117463374443194 0.195955898983195 1.0394916577227 0.45 26.2 26 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0130991356550435 0.0311706856808143 1.03550893106476 0.448275862068966 26.2 26 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0130991356550435 0.0311706856808143 1.03550893106476 0.448275862068966 26.2 26 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0130991356550435 0.0311706856808143 1.03550893106476 0.448275862068966 26.2 26 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.36149251503557e-05 7.45155326498312e-05 1.03467919634436 0.447916666666667 26.2 26 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00113748387362186 0.00383563874920357 1.03399170186174 0.447619047619048 26.2 26 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0412190298905759 0.0824960331002666 1.03341275913953 0.447368421052632 26.2 26 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.15605990395145e-11 2.45533319898941e-10 1.02822345547097 0.445121951219512 26.2 26 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0117642599122536 0.0282779423228664 1.02665842738045 0.444444444444444 26.2 26 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0188193652960063 0.0430545929521172 1.02665842738045 0.444444444444444 26.2 26 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.44470893841756e-10 2.6356677171387e-09 1.02550746501791 0.443946188340807 26.2 26 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0365958230063759 0.0749292894072992 1.02068948303521 0.441860465116279 26.2 26 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.101932934407346 0.171252143638316 1.01639184310664 0.44 26.2 26 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.02770377873316e-20 1.12494036702868e-18 1.01509695860364 0.439439439439439 26.2 26 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.180285156485793 0.281300194823776 1.01061688945263 0.4375 26.2 26 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0324305227244678 0.0670765026699384 1.01061688945263 0.4375 26.2 26 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 4.36756773360705e-05 0.00021431203051458 1.00841830303613 0.436548223350254 26.2 26 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0530442538692589 0.102696562253001 1.00691499608467 0.435897435897436 26.2 26 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0388861560989348 0.0787126602116418 1.00433976591566 0.434782608695652 26.2 26 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0388861560989348 0.0787126602116418 1.00433976591566 0.434782608695652 26.2 26 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.124650583461436 0.206734009633594 1.00433976591566 0.434782608695652 26.2 26 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0885168059406024 0.156277189644513 1.00099196669594 0.433333333333333 26.2 26 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0638897748856546 0.120897805401977 0.998910902316113 0.432432432432432 26.2 26 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 8.02039773645202e-06 4.54389780849367e-05 0.996462591281024 0.431372549019608 26.2 26 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 8.569491994505e-10 1.34004253936051e-08 0.993992022872889 0.43030303030303 26.2 26 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.224815382274179 0.333589456700894 0.989992054974004 0.428571428571429 26.2 26 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.224815382274179 0.333589456700894 0.989992054974004 0.428571428571429 26.2 26 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.224815382274179 0.333589456700894 0.989992054974004 0.428571428571429 26.2 26 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0670409291814642 0.126189473842888 0.981742121182554 0.425 26.2 26 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.130308834410192 0.212404892744219 0.977299849141004 0.423076923076923 26.2 26 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.130308834410192 0.212404892744219 0.977299849141004 0.423076923076923 26.2 26 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.130308834410192 0.212404892744219 0.977299849141004 0.423076923076923 26.2 26 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0584798444476376 0.112912915398899 0.975325506011427 0.422222222222222 26.2 26 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.111807553497386 0.18695904656496 0.968701903254133 0.419354838709677 26.2 26 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0698193816092374 0.131245680356598 0.966968983928097 0.418604651162791 26.2 26 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0446864989542318 0.0883179000164887 0.965992247580695 0.418181818181818 26.2 26 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0446864989542318 0.0883179000164887 0.965992247580695 0.418181818181818 26.2 26 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.281928442812536 0.405236539517413 0.962492275669171 0.416666666666667 26.2 26 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.281928442812536 0.405236539517413 0.962492275669171 0.416666666666667 26.2 26 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.281928442812536 0.405236539517413 0.962492275669171 0.416666666666667 26.2 26 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.281928442812536 0.405236539517413 0.962492275669171 0.416666666666667 26.2 26 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.230704847289813 0.341971872597296 0.951168837131887 0.411764705882353 26.2 26 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0477789127364482 0.0939080011380743 0.946713713772955 0.409836065573771 26.2 26 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0744242295670002 0.13753984243356 0.942849576165719 0.408163265306122 26.2 26 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0320462991581717 0.066378287775951 0.942229280391925 0.407894736842105 26.2 26 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0429279005662234 0.0850785550219162 0.93738378152128 0.405797101449275 26.2 26 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0222824736411277 0.0499337952619286 0.933822292989664 0.404255319148936 26.2 26 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0106753957527131 0.0267920426033699 0.927630350723673 0.401574803149606 26.2 26 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0779860680398057 0.142823905818074 0.923992584642404 0.4 26.2 26 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.165630862567508 0.260531238922413 0.923992584642404 0.4 26.2 26 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.165630862567508 0.260531238922413 0.923992584642404 0.4 26.2 26 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.165630862567508 0.260531238922413 0.923992584642404 0.4 26.2 26 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.195879084831846 0.304629440126467 0.923992584642404 0.4 26.2 26 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.195879084831846 0.304629440126467 0.923992584642404 0.4 26.2 26 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.234169326878722 0.34674604802125 0.923992584642404 0.4 26.2 26 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.284602182490302 0.407433506724044 0.923992584642404 0.4 26.2 26 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.284602182490302 0.407433506724044 0.923992584642404 0.4 26.2 26 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.284602182490302 0.407433506724044 0.923992584642404 0.4 26.2 26 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00531104326668978 0.0142596501292444 0.921158251560679 0.398773006134969 26.2 26 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.105967495030913 0.177820454515317 0.914367661885712 0.395833333333333 26.2 26 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0807194822657869 0.145951490805864 0.908845165222037 0.39344262295082 26.2 26 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0369758205517021 0.0755985526509657 0.904941191144623 0.391752577319588 26.2 26 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.236053908338573 0.348810707752637 0.903905789324091 0.391304347826087 26.2 26 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0427190264030759 0.0847826702532456 0.899676990309709 0.389473684210526 26.2 26 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.169633700740894 0.265147762934195 0.898326123957893 0.388888888888889 26.2 26 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.199624531453901 0.307098062982596 0.894186372234585 0.387096774193548 26.2 26 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.352042006625427 0.481145041714055 0.888454408310004 0.384615384615385 26.2 26 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.352042006625427 0.481145041714055 0.888454408310004 0.384615384615385 26.2 26 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.352042006625427 0.481145041714055 0.888454408310004 0.384615384615385 26.2 26 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.352042006625427 0.481145041714055 0.888454408310004 0.384615384615385 26.2 26 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.352042006625427 0.481145041714055 0.888454408310004 0.384615384615385 26.2 26 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0168950534879425 0.0392196755519448 0.886219302880293 0.383647798742138 26.2 26 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0168950534879425 0.0392196755519448 0.886219302880293 0.383647798742138 26.2 26 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00543485182519771 0.0145372070437149 0.882353433832339 0.381974248927039 26.2 26 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.284294802474648 0.407433506724044 0.879992937754671 0.380952380952381 26.2 26 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0222205742151978 0.0498736231990953 0.875210367440786 0.37888198757764 26.2 26 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.200767987651141 0.308523592254399 0.874047039526598 0.378378378378378 26.2 26 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0253484449234821 0.0557173598465303 0.869807834308436 0.376543209876543 26.2 26 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.129075464936191 0.211119984602528 0.866243048102254 0.375 26.2 26 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.236400239072689 0.348960103942361 0.866243048102254 0.375 26.2 26 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.347192398093008 0.481145041714055 0.866243048102254 0.375 26.2 26 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.347192398093008 0.481145041714055 0.866243048102254 0.375 26.2 26 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0466809823205118 0.0918769541384347 0.857993114310804 0.371428571428571 26.2 26 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.235487361135396 0.348335254569301 0.857993114310804 0.371428571428571 26.2 26 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.086792535001181 0.153805451191383 0.854693140794224 0.37 26.2 26 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.34202376751461 0.479980099776421 0.85104580164432 0.368421052631579 26.2 26 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.27551291018923 0.397621573224416 0.839993258765822 0.363636363636364 26.2 26 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.27551291018923 0.397621573224416 0.839993258765822 0.363636363636364 26.2 26 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.336771087916236 0.473075279471673 0.839993258765822 0.363636363636364 26.2 26 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.336771087916236 0.473075279471673 0.839993258765822 0.363636363636364 26.2 26 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0658726798002187 0.124154732921472 0.834573947418946 0.361290322580645 26.2 26 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0251991303642435 0.0555943604780132 0.833405076344129 0.36078431372549 26.2 26 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0834906313948311 0.150770518369092 0.829641229168356 0.359154929577465 26.2 26 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0938274899287253 0.161642273811836 0.826197749041566 0.357664233576642 26.2 26 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0938274899287253 0.161642273811836 0.826197749041566 0.357664233576642 26.2 26 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.422723464598342 0.563763345945117 0.824993379145004 0.357142857142857 26.2 26 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.422723464598342 0.563763345945117 0.824993379145004 0.357142857142857 26.2 26 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.321370874325905 0.453681303735877 0.819670841215036 0.354838709677419 26.2 26 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.260871938509093 0.378410569315433 0.818118434318795 0.354166666666667 26.2 26 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.410731062167478 0.549241253702529 0.815287574684474 0.352941176470588 26.2 26 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.410731062167478 0.549241253702529 0.815287574684474 0.352941176470588 26.2 26 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.410731062167478 0.549241253702529 0.815287574684474 0.352941176470588 26.2 26 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.190520813340557 0.296945364056531 0.799608967479004 0.346153846153846 26.2 26 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.155607392798336 0.249076850339744 0.798302416878548 0.345588235294118 26.2 26 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.221556365889017 0.329785260104677 0.795660281219848 0.344444444444444 26.2 26 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.219022466068644 0.326354941587099 0.794832330875186 0.344086021505376 26.2 26 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.249728264810546 0.367490507575395 0.788111322194992 0.341176470588235 26.2 26 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.249728264810546 0.367490507575395 0.788111322194992 0.341176470588235 26.2 26 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.246567423648248 0.363591133524826 0.787493680092958 0.340909090909091 26.2 26 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.333503987394685 0.469877400062016 0.786376667780769 0.340425531914894 26.2 26 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.32788852505172 0.462423559116549 0.785393696946044 0.34 26.2 26 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.411062498378913 0.549241253702529 0.769993820535337 0.333333333333333 26.2 26 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.411062498378913 0.549241253702529 0.769993820535337 0.333333333333333 26.2 26 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.411062498378913 0.549241253702529 0.769993820535337 0.333333333333333 26.2 26 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.432207312387623 0.575333026686237 0.769993820535337 0.333333333333333 26.2 26 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.432207312387623 0.575333026686237 0.769993820535337 0.333333333333333 26.2 26 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.473552018737877 0.611501649442499 0.769993820535337 0.333333333333333 26.2 26 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.473552018737877 0.611501649442499 0.769993820535337 0.333333333333333 26.2 26 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.473552018737877 0.611501649442499 0.769993820535337 0.333333333333333 26.2 26 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.376273548085586 0.50560647679489 0.757370971018364 0.327868852459016 26.2 26 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.497474606267246 0.638328552496205 0.739194067713923 0.32 26.2 26 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.334585668658128 0.470935120178552 0.736696790458133 0.318918918918919 26.2 26 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.514575622032851 0.642316763291883 0.734994101420094 0.318181818181818 26.2 26 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.534257365456308 0.665134060406234 0.729467829980845 0.315789473684211 26.2 26 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0892256612182051 0.157333476968409 0.72905268568736 0.315609756097561 26.2 26 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.501039993066845 0.642175943755745 0.725994173647603 0.314285714285714 26.2 26 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.515439696980685 0.642831453815525 0.721869206751878 0.3125 26.2 26 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.531292770718695 0.662022427962086 0.716890798429451 0.310344827586207 26.2 26 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.56654089764721 0.702254091770017 0.690177387918869 0.298780487804878 26.2 26 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.620123781031074 0.761377170325469 0.67374459296842 0.291666666666667 26.2 26 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.623397216970041 0.761454283045809 0.670639779175939 0.290322580645161 26.2 26 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.650933273664069 0.792694895676167 0.659994703316003 0.285714285714286 26.2 26 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.665625395282119 0.797984669891804 0.65153323276067 0.282051282051282 26.2 26 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.665641463922397 0.797984669891804 0.64968228607669 0.28125 26.2 26 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.694259228766679 0.821905892292 0.629994944074367 0.272727272727273 26.2 26 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.770566378092871 0.886431654022761 0.629994944074367 0.272727272727273 26.2 26 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.794075426977288 0.911265590797323 0.614045704983876 0.265822784810127 26.2 26 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.724555437965502 0.85563683670117 0.607889858317371 0.263157894736842 26.2 26 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.724555437965502 0.85563683670117 0.607889858317371 0.263157894736842 26.2 26 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.85866701987854 0.969748547053303 0.584805433317977 0.253164556962025 26.2 26 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.768822681672331 0.885141323640555 0.577495365401503 0.25 26.2 26 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.777980361522122 0.89423752378512 0.577495365401503 0.25 26.2 26 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.787002510672081 0.903877782636297 0.577495365401503 0.25 26.2 26 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.843112461479402 0.955417792641631 0.533072644986002 0.230769230769231 26.2 26 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.891782626251376 0.996863061394901 0.494996027487002 0.214285714285714 26.2 26 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.967570933460037 1 0.488024252451974 0.211267605633803 26.2 26 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.92461983129056 1 0.486311886653897 0.210526315789474 26.2 26 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.954866986941947 1 0.479430114672945 0.207547169811321 26.2 26 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.913183431892352 1 0.461996292321202 0.2 26.2 26 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999898072937411 1 0.447093186117292 0.193548387096774 26.2 26 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999626512833 1 0.446517035104255 0.193298969072165 26.2 26 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.94362546262522 1 0.427774344741854 0.185185185185185 26.2 26 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999928416567604 1 0.422254675777443 0.182795698924731 26.2 26 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.960875921952808 1 0.419996629382911 0.181818181818182 26.2 26 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999925867193 1 0.387746888198152 0.167857142857143 26.2 26 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.977475649790128 1 0.372577655097744 0.161290322580645 26.2 26 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.362692303375587 0.157010915197313 26.2 26 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999422173649 1 0.341247261373615 0.147727272727273 26.2 26 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.989117772103073 1 0.339703156118531 0.147058823529412 26.2 26 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.991515867586685 1 0.329997351658001 0.142857142857143 26.2 26 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.302845670825381 0.131103074141049 26.2 26 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999992762906166 1 0.299442041319298 0.12962962962963 26.2 26 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.99973322210953 1 0.240623068917293 0.104166666666667 26.2 26 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.99973322210953 1 0.240623068917293 0.104166666666667 26.2 26 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999998965290466 1 0.230998146160601 0.1 26.2 26 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 2.10316307651694e-06 9.78039561399869e-06 1.97135850048174 1 26.1 26 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 6.25324999245298e-06 2.68023335519897e-05 1.97135850048174 1 26.1 26 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 5.52707902952619e-05 0.000201151750869969 1.97135850048174 1 26.1 26 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 5.52707902952619e-05 0.000201151750869969 1.97135850048174 1 26.1 26 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 5.52707902952619e-05 0.000201151750869969 1.97135850048174 1 26.1 26 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000488409955591713 0.00149786070432545 1.97135850048174 1 26.1 26 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.000488409955591713 0.00149786070432545 1.97135850048174 1 26.1 26 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00145174733798613 0.00398810127790398 1.97135850048174 1 26.1 26 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00145174733798613 0.00398810127790398 1.97135850048174 1 26.1 26 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00145174733798613 0.00398810127790398 1.97135850048174 1 26.1 26 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00145174733798613 0.00398810127790398 1.97135850048174 1 26.1 26 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00145174733798613 0.00398810127790398 1.97135850048174 1 26.1 26 1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.00431491569901432 0.0100328840517931 1.97135850048174 1 26.1 26 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000164305734389877 0.000551431745369798 1.97135850048174 1 26.1 26 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.000164305734389877 0.000551431745369798 1.97135850048174 1 26.1 26 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 7.42797559259596e-11 8.95763497310513e-10 1.89250416046247 0.96 26.1 26 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 3.12539510431492e-07 1.64112075034691e-06 1.85539623574752 0.941176470588235 26.1 26 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 2.44815572080325e-06 1.10946674863154e-05 1.83993460044962 0.933333333333333 26.1 26 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 2.44815572080325e-06 1.10946674863154e-05 1.83993460044962 0.933333333333333 26.1 26 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 2.44815572080325e-06 1.10946674863154e-05 1.83993460044962 0.933333333333333 26.1 26 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 6.8102034088036e-06 2.90147288943938e-05 1.83054717901876 0.928571428571429 26.1 26 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 1.88533015631294e-05 7.64337553399803e-05 1.81971553890622 0.923076923076923 26.1 26 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 1.88533015631294e-05 7.64337553399803e-05 1.81971553890622 0.923076923076923 26.1 26 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 1.88533015631294e-05 7.64337553399803e-05 1.81971553890622 0.923076923076923 26.1 26 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 1.79999086260336e-09 1.54300421535215e-08 1.8136498204432 0.92 26.1 26 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 1.79999086260336e-09 1.54300421535215e-08 1.8136498204432 0.92 26.1 26 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 4.93559052730832e-09 3.69254139087028e-08 1.80707862544159 0.916666666666667 26.1 26 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 5.19042060677495e-05 0.000194767597128936 1.80707862544159 0.916666666666667 26.1 26 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 5.19042060677495e-05 0.000194767597128936 1.80707862544159 0.916666666666667 26.1 26 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 5.19042060677495e-05 0.000194767597128936 1.80707862544159 0.916666666666667 26.1 26 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000141973498382172 0.000481614377701882 1.79214409134703 0.909090909090909 26.1 26 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.000141973498382172 0.000481614377701882 1.79214409134703 0.909090909090909 26.1 26 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.68465574530218e-07 1.41491300946852e-06 1.77422265043356 0.9 26.1 26 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.68465574530218e-07 1.41491300946852e-06 1.77422265043356 0.9 26.1 26 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 8.68757822661383e-12 1.24872967843146e-10 1.75231866709488 0.888888888888889 26.1 26 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 1.92412047282842e-06 9.00665602906198e-06 1.75231866709488 0.888888888888889 26.1 26 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0010365852871468 0.0029209126012077 1.75231866709488 0.888888888888889 26.1 26 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0010365852871468 0.0029209126012077 1.75231866709488 0.888888888888889 26.1 26 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0010365852871468 0.0029209126012077 1.75231866709488 0.888888888888889 26.1 26 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 2.79299880684779e-08 1.84857548936949e-07 1.73479548042393 0.88 26.1 26 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 2.79299880684779e-08 1.84857548936949e-07 1.73479548042393 0.88 26.1 26 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 1.34507196051604e-05 5.54793449221545e-05 1.72493868792152 0.875 26.1 26 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00275713950400456 0.00708085940476468 1.72493868792152 0.875 26.1 26 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00275713950400456 0.00708085940476468 1.72493868792152 0.875 26.1 26 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.00275713950400456 0.00708085940476468 1.72493868792152 0.875 26.1 26 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00275713950400456 0.00708085940476468 1.72493868792152 0.875 26.1 26 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00275713950400456 0.00708085940476468 1.72493868792152 0.875 26.1 26 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00275713950400456 0.00708085940476468 1.72493868792152 0.875 26.1 26 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00275713950400456 0.00708085940476468 1.72493868792152 0.875 26.1 26 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00275713950400456 0.00708085940476468 1.72493868792152 0.875 26.1 26 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.91518356982601e-07 1.03623810641156e-06 1.7142247830276 0.869565217391304 26.1 26 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 2.8472474738479e-09 2.31521894587746e-08 1.70851070041751 0.866666666666667 26.1 26 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 3.51635133808058e-05 0.000137089532988731 1.70851070041751 0.866666666666667 26.1 26 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 4.97174080865747e-07 2.56332868504333e-06 1.70253688677968 0.863636363636364 26.1 26 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 9.11118904890838e-05 0.000324942907684126 1.68973585755578 0.857142857142857 26.1 26 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 9.11118904890838e-05 0.000324942907684126 1.68973585755578 0.857142857142857 26.1 26 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00723177163235263 0.0160293006742022 1.68973585755578 0.857142857142857 26.1 26 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 1.2822687329909e-06 6.18531663405443e-06 1.68973585755578 0.857142857142857 26.1 26 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.2822687329909e-06 6.18531663405443e-06 1.68973585755578 0.857142857142857 26.1 26 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.2822687329909e-06 6.18531663405443e-06 1.68973585755578 0.857142857142857 26.1 26 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 3.28355173983295e-06 1.4376905002407e-05 1.67565472540948 0.85 26.1 26 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.23335811666977e-07 7.53248326189305e-07 1.6680725773307 0.846153846153846 26.1 26 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.000233684180843161 0.000755755884863222 1.6680725773307 0.846153846153846 26.1 26 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.19556936204685e-08 8.21881740189694e-08 1.65339745201694 0.838709677419355 26.1 26 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 2.10095245556609e-05 8.46927859566727e-05 1.64279875040145 0.833333333333333 26.1 26 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.82645769339052e-12 2.98741298585599e-11 1.64279875040145 0.833333333333333 26.1 26 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 7.82421801120403e-07 3.86592438539699e-06 1.64279875040145 0.833333333333333 26.1 26 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 7.82421801120403e-07 3.86592438539699e-06 1.64279875040145 0.833333333333333 26.1 26 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 7.82421801120403e-07 3.86592438539699e-06 1.64279875040145 0.833333333333333 26.1 26 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.000592319959954289 0.00178953567519098 1.64279875040145 0.833333333333333 26.1 26 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000592319959954289 0.00178953567519098 1.64279875040145 0.833333333333333 26.1 26 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000592319959954289 0.00178953567519098 1.64279875040145 0.833333333333333 26.1 26 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.000592319959954289 0.00178953567519098 1.64279875040145 0.833333333333333 26.1 26 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0186307575041553 0.0373402365188915 1.64279875040145 0.833333333333333 26.1 26 1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0186307575041553 0.0373402365188915 1.64279875040145 0.833333333333333 26.1 26 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0186307575041553 0.0373402365188915 1.64279875040145 0.833333333333333 26.1 26 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0186307575041553 0.0373402365188915 1.64279875040145 0.833333333333333 26.1 26 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0186307575041553 0.0373402365188915 1.64279875040145 0.833333333333333 26.1 26 1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0186307575041553 0.0373402365188915 1.64279875040145 0.833333333333333 26.1 26 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.90224931530735e-09 2.3465345316377e-08 1.63341132897058 0.828571428571429 26.1 26 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 4.50337465241601e-13 8.65986774376754e-12 1.63016183693682 0.826923076923077 26.1 26 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 4.50337465241601e-13 8.65986774376754e-12 1.63016183693682 0.826923076923077 26.1 26 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.94903876931068e-06 9.09338415976755e-06 1.62851354387622 0.826086956521739 26.1 26 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.11182417973998e-12 1.92942171679268e-11 1.62347170627908 0.823529411764706 26.1 26 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.11182417973998e-12 1.92942171679268e-11 1.62347170627908 0.823529411764706 26.1 26 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 5.23973123805071e-05 0.000194767597128936 1.62347170627908 0.823529411764706 26.1 26 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 5.23973123805071e-05 0.000194767597128936 1.62347170627908 0.823529411764706 26.1 26 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 5.23973123805071e-05 0.000194767597128936 1.62347170627908 0.823529411764706 26.1 26 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 5.23973123805071e-05 0.000194767597128936 1.62347170627908 0.823529411764706 26.1 26 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 4.81519466755409e-06 2.08903110119801e-05 1.61292968221233 0.818181818181818 26.1 26 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 4.81519466755409e-06 2.08903110119801e-05 1.61292968221233 0.818181818181818 26.1 26 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00148073573113946 0.00404431275510836 1.61292968221233 0.818181818181818 26.1 26 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00148073573113946 0.00404431275510836 1.61292968221233 0.818181818181818 26.1 26 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00148073573113946 0.00404431275510836 1.61292968221233 0.818181818181818 26.1 26 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.69407245379032e-12 9.82027330076663e-11 1.60927224529121 0.816326530612245 26.1 26 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.66579085939483e-10 1.92717105115353e-09 1.60459412829909 0.813953488372093 26.1 26 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 4.31996373597315e-08 2.73213706501768e-07 1.60172878164141 0.8125 26.1 26 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000129252286408603 0.000442129816248657 1.60172878164141 0.8125 26.1 26 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000129252286408603 0.000442129816248657 1.60172878164141 0.8125 26.1 26 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.000129252286408603 0.000442129816248657 1.60172878164141 0.8125 26.1 26 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.000129252286408603 0.000442129816248657 1.60172878164141 0.8125 26.1 26 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000129252286408603 0.000442129816248657 1.60172878164141 0.8125 26.1 26 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.000129252286408603 0.000442129816248657 1.60172878164141 0.8125 26.1 26 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000129252286408603 0.000442129816248657 1.60172878164141 0.8125 26.1 26 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 3.8900683806332e-12 5.88890138897984e-11 1.59225109654294 0.807692307692308 26.1 26 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.00941656729567e-08 7.07586096188049e-08 1.58803879205473 0.805555555555556 26.1 26 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 9.79409506109395e-10 9.10914854374947e-09 1.58670318331457 0.804878048780488 26.1 26 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.29798208537727e-10 2.61602280599348e-09 1.57708680038539 0.8 26.1 26 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 2.43024471767857e-08 1.6235860250031e-07 1.57708680038539 0.8 26.1 26 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.52964604192863e-07 1.36351754456987e-06 1.57708680038539 0.8 26.1 26 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 2.665197051164e-06 1.19263377478188e-05 1.57708680038539 0.8 26.1 26 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 2.665197051164e-06 1.19263377478188e-05 1.57708680038539 0.8 26.1 26 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 2.85768480315514e-05 0.000111716633925543 1.57708680038539 0.8 26.1 26 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 2.85768480315514e-05 0.000111716633925543 1.57708680038539 0.8 26.1 26 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.000314905398922196 0.0010002463898801 1.57708680038539 0.8 26.1 26 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000314905398922196 0.0010002463898801 1.57708680038539 0.8 26.1 26 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000314905398922196 0.0010002463898801 1.57708680038539 0.8 26.1 26 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000314905398922196 0.0010002463898801 1.57708680038539 0.8 26.1 26 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000314905398922196 0.0010002463898801 1.57708680038539 0.8 26.1 26 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00364138718201815 0.00910666776803486 1.57708680038539 0.8 26.1 26 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00364138718201815 0.00910666776803486 1.57708680038539 0.8 26.1 26 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00364138718201815 0.00910666776803486 1.57708680038539 0.8 26.1 26 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00364138718201815 0.00910666776803486 1.57708680038539 0.8 26.1 26 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00364138718201815 0.00910666776803486 1.57708680038539 0.8 26.1 26 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00364138718201815 0.00910666776803486 1.57708680038539 0.8 26.1 26 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00364138718201815 0.00910666776803486 1.57708680038539 0.8 26.1 26 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00364138718201815 0.00910666776803486 1.57708680038539 0.8 26.1 26 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.49273460158416e-10 5.39045609520983e-09 1.56812607992866 0.795454545454545 26.1 26 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.49273460158416e-10 5.39045609520983e-09 1.56812607992866 0.795454545454545 26.1 26 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 5.81218994600706e-08 3.61167960400351e-07 1.56549057391197 0.794117647058823 26.1 26 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.23461087665649e-13 2.83363109271319e-12 1.56457023847757 0.793650793650794 26.1 26 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.26130476956741e-11 1.74255989038293e-10 1.56220862302326 0.792452830188679 26.1 26 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 6.3821832484338e-06 2.72728131006646e-05 1.56065881288138 0.791666666666667 26.1 26 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 1.30565209770368e-09 1.14687835495823e-08 1.55874858177626 0.790697674418605 26.1 26 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 6.85119503962274e-05 0.000248705370953652 1.55633565827506 0.789473684210526 26.1 26 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.02961378279506e-10 3.16995618596865e-09 1.55192052165584 0.787234042553192 26.1 26 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 3.08561540204515e-09 2.48069532040127e-08 1.54892453609279 0.785714285714286 26.1 26 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000756449245474778 0.0022378945453443 1.54892453609279 0.785714285714286 26.1 26 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.000756449245474778 0.0022378945453443 1.54892453609279 0.785714285714286 26.1 26 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000756449245474778 0.0022378945453443 1.54892453609279 0.785714285714286 26.1 26 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000756449245474778 0.0022378945453443 1.54892453609279 0.785714285714286 26.1 26 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000756449245474778 0.0022378945453443 1.54892453609279 0.785714285714286 26.1 26 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.000756449245474778 0.0022378945453443 1.54892453609279 0.785714285714286 26.1 26 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.000756449245474778 0.0022378945453443 1.54892453609279 0.785714285714286 26.1 26 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.000756449245474778 0.0022378945453443 1.54892453609279 0.785714285714286 26.1 26 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 7.12787757012008e-10 6.71719853131184e-09 1.54280230472484 0.782608695652174 26.1 26 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.66743684083083e-09 1.44680647835504e-08 1.53327883370802 0.777777777777778 26.1 26 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000162254569767468 0.000547128561087932 1.53327883370802 0.777777777777778 26.1 26 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000162254569767468 0.000547128561087932 1.53327883370802 0.777777777777778 26.1 26 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00877907926300677 0.0188425788706767 1.53327883370802 0.777777777777778 26.1 26 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00877907926300677 0.0188425788706767 1.53327883370802 0.777777777777778 26.1 26 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00877907926300677 0.0188425788706767 1.53327883370802 0.777777777777778 26.1 26 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00877907926300677 0.0188425788706767 1.53327883370802 0.777777777777778 26.1 26 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00877907926300677 0.0188425788706767 1.53327883370802 0.777777777777778 26.1 26 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.00877907926300677 0.0188425788706767 1.53327883370802 0.777777777777778 26.1 26 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00877907926300677 0.0188425788706767 1.53327883370802 0.777777777777778 26.1 26 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.00877907926300677 0.0188425788706767 1.53327883370802 0.777777777777778 26.1 26 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.70227865373858e-19 1.2163593876559e-17 1.53327883370802 0.777777777777778 26.1 26 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 3.82010717712636e-11 4.81063054252284e-10 1.53327883370802 0.777777777777778 26.1 26 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 7.60575716979539e-07 3.79754121144521e-06 1.52621303263102 0.774193548387097 26.1 26 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 3.54999580135269e-05 0.000138023060801226 1.52332247764498 0.772727272727273 26.1 26 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.11176921820471e-13 2.59352065164803e-12 1.5207622718002 0.771428571428571 26.1 26 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 1.72262550916156e-07 9.50114767262362e-07 1.5207622718002 0.771428571428571 26.1 26 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 7.8726034491503e-06 3.3046356071212e-05 1.51642961575518 0.769230769230769 26.1 26 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 7.8726034491503e-06 3.3046356071212e-05 1.51642961575518 0.769230769230769 26.1 26 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 7.8726034491503e-06 3.3046356071212e-05 1.51642961575518 0.769230769230769 26.1 26 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 7.8726034491503e-06 3.3046356071212e-05 1.51642961575518 0.769230769230769 26.1 26 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 7.8726034491503e-06 3.3046356071212e-05 1.51642961575518 0.769230769230769 26.1 26 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00178777255699138 0.00478195554247882 1.51642961575518 0.769230769230769 26.1 26 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00178777255699138 0.00478195554247882 1.51642961575518 0.769230769230769 26.1 26 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00178777255699138 0.00478195554247882 1.51642961575518 0.769230769230769 26.1 26 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00178777255699138 0.00478195554247882 1.51642961575518 0.769230769230769 26.1 26 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.56300885800259e-13 5.41041529733563e-12 1.51423189167438 0.768115942028985 26.1 26 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.56300885800259e-13 5.41041529733563e-12 1.51423189167438 0.768115942028985 26.1 26 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.27317589104479e-16 1.1089831649897e-14 1.51290303525343 0.767441860465116 26.1 26 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 2.05403772377294e-09 1.72952407155556e-08 1.50997672377325 0.765957446808511 26.1 26 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.05403772377294e-09 1.72952407155556e-08 1.50997672377325 0.765957446808511 26.1 26 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.36554000213254e-13 3.08438638576922e-12 1.50589885453466 0.763888888888889 26.1 26 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.08793473682055e-10 1.27944721528566e-09 1.50540103673151 0.763636363636364 26.1 26 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 8.22979472719989e-05 0.000295732270121349 1.50198742893847 0.761904761904762 26.1 26 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 8.22979472719989e-05 0.000295732270121349 1.50198742893847 0.761904761904762 26.1 26 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 8.22979472719989e-05 0.000295732270121349 1.50198742893847 0.761904761904762 26.1 26 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.34474589191525e-12 2.30551012553662e-11 1.50058632126222 0.761194029850746 26.1 26 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.70495665298168e-09 3.65855372524204e-08 1.49994668514915 0.760869565217391 26.1 26 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.81526395397881e-05 7.44415160378053e-05 1.49823246036612 0.76 26.1 26 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 9.10578641007473e-07 4.48357579983957e-06 1.49345340945586 0.757575757575758 26.1 26 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.0707947577531e-08 7.43288263552516e-08 1.48947086703065 0.755555555555556 26.1 26 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 2.99739376047486e-11 3.87753756468702e-10 1.48659821347803 0.754098360655738 26.1 26 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.99739376047486e-11 3.87753756468702e-10 1.48659821347803 0.754098360655738 26.1 26 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.60408228601453e-12 2.65419661976591e-11 1.48566147862392 0.753623188405797 26.1 26 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 3.71806926954344e-13 7.45184869093002e-12 1.48527010310268 0.753424657534247 26.1 26 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 8.37406070620671e-13 1.54756992012106e-11 1.4785188753613 0.75 26.1 26 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.42059588294156e-08 1.6235860250031e-07 1.4785188753613 0.75 26.1 26 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.06088081189302e-07 6.50704049708519e-07 1.4785188753613 0.75 26.1 26 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000188317257490255 0.000626314663566594 1.4785188753613 0.75 26.1 26 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000188317257490255 0.000626314663566594 1.4785188753613 0.75 26.1 26 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.92979606538427e-10 3.10469220171921e-09 1.4785188753613 0.75 26.1 26 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.27274420171088e-09 1.14687835495823e-08 1.4785188753613 0.75 26.1 26 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 9.20659356858475e-06 3.8532301906165e-05 1.4785188753613 0.75 26.1 26 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 4.138687385962e-05 0.000158940242050737 1.4785188753613 0.75 26.1 26 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 4.138687385962e-05 0.000158940242050737 1.4785188753613 0.75 26.1 26 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 4.138687385962e-05 0.000158940242050737 1.4785188753613 0.75 26.1 26 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00414598304469498 0.00984930529649575 1.4785188753613 0.75 26.1 26 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00414598304469498 0.00984930529649575 1.4785188753613 0.75 26.1 26 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00414598304469498 0.00984930529649575 1.4785188753613 0.75 26.1 26 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00414598304469498 0.00984930529649575 1.4785188753613 0.75 26.1 26 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00414598304469498 0.00984930529649575 1.4785188753613 0.75 26.1 26 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000871864736462974 0.00255806911337487 1.4785188753613 0.75 26.1 26 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000871864736462974 0.00255806911337487 1.4785188753613 0.75 26.1 26 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0206556680173968 0.0404814795399559 1.4785188753613 0.75 26.1 26 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0206556680173968 0.0404814795399559 1.4785188753613 0.75 26.1 26 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0206556680173968 0.0404814795399559 1.4785188753613 0.75 26.1 26 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.50190411168987e-11 4.48937797381503e-10 1.47069602416892 0.746031746031746 26.1 26 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 6.57158464338907e-10 6.23424329836176e-09 1.46955815490457 0.745454545454545 26.1 26 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 6.57158464338907e-10 6.23424329836176e-09 1.46955815490457 0.745454545454545 26.1 26 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 6.57158464338907e-10 6.23424329836176e-09 1.46955815490457 0.745454545454545 26.1 26 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.40136496558323e-41 4.27142793253117e-39 1.46530095438106 0.743295019157088 26.1 26 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 3.38046727156133e-10 3.48580067205201e-09 1.46152440552956 0.741379310344828 26.1 26 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.46534295638209e-09 1.27925339075565e-08 1.4602655559124 0.740740740740741 26.1 26 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.07114061403682e-05 8.3728212891318e-05 1.4602655559124 0.740740740740741 26.1 26 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.17453485304029e-45 2.38766156553762e-43 1.46001636383801 0.74061433447099 26.1 26 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.16068784735656e-12 3.45467281661616e-11 1.45826519213718 0.73972602739726 26.1 26 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.73531274806667e-19 1.2163593876559e-17 1.45781132808734 0.739495798319328 26.1 26 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.73351876543903e-10 1.98935258324172e-09 1.45428086101112 0.737704918032787 26.1 26 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.58544090104584e-13 5.41041529733563e-12 1.45387689410528 0.7375 26.1 26 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 5.30510012638051e-07 2.72532761005035e-06 1.45257994772339 0.736842105263158 26.1 26 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.7493131203524e-25 1.31014345803235e-23 1.4513068715203 0.736196319018405 26.1 26 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 3.24741809459566e-09 2.59611008348855e-08 1.45062229280732 0.735849056603774 26.1 26 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 2.33521896746398e-06 1.06849408061133e-05 1.44952830917775 0.735294117647059 26.1 26 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.33521896746398e-06 1.06849408061133e-05 1.44952830917775 0.735294117647059 26.1 26 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 2.33521896746398e-06 1.06849408061133e-05 1.44952830917775 0.735294117647059 26.1 26 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.65125325570854e-26 4.13670836429578e-24 1.44644055656648 0.733727810650888 26.1 26 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.71547739433843e-32 7.3937493928578e-30 1.44566290035327 0.733333333333333 26.1 26 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 3.82521559573197e-10 3.88805842337613e-09 1.44566290035327 0.733333333333333 26.1 26 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.82521559573197e-10 3.88805842337613e-09 1.44566290035327 0.733333333333333 26.1 26 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 1.03349990385218e-05 4.30020574029723e-05 1.44566290035327 0.733333333333333 26.1 26 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.03349990385218e-05 4.30020574029723e-05 1.44566290035327 0.733333333333333 26.1 26 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00197069482349437 0.00521245117812731 1.44566290035327 0.733333333333333 26.1 26 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00197069482349437 0.00521245117812731 1.44566290035327 0.733333333333333 26.1 26 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.26749136827281e-20 4.0567724886387e-18 1.44359323263623 0.732283464566929 26.1 26 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.6755890113693e-07 1.41491300946852e-06 1.44245743937688 0.731707317073171 26.1 26 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.6755890113693e-07 1.41491300946852e-06 1.44245743937688 0.731707317073171 26.1 26 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.6755890113693e-07 1.41491300946852e-06 1.44245743937688 0.731707317073171 26.1 26 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.6755890113693e-07 1.41491300946852e-06 1.44245743937688 0.731707317073171 26.1 26 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 4.60555946429479e-05 0.000174765629805106 1.44060813496742 0.730769230769231 26.1 26 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.74307057431219e-17 1.02720774401217e-15 1.43855890575694 0.72972972972973 26.1 26 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.1712771999436e-06 5.72758575779982e-06 1.43855890575694 0.72972972972973 26.1 26 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.1712771999436e-06 5.72758575779982e-06 1.43855890575694 0.72972972972973 26.1 26 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.14944918768898e-25 9.08703441156346e-24 1.43793208270433 0.729411764705882 26.1 26 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 8.39215443912595e-10 7.85660247820804e-09 1.43675280543584 0.728813559322034 26.1 26 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.62050160183052e-09 2.84639435326234e-08 1.43371527307763 0.727272727272727 26.1 26 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.62050160183052e-09 2.84639435326234e-08 1.43371527307763 0.727272727272727 26.1 26 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.62050160183052e-09 2.84639435326234e-08 1.43371527307763 0.727272727272727 26.1 26 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000207092585294591 0.000685331974126052 1.43371527307763 0.727272727272727 26.1 26 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.00940312438436134 0.0196774205866856 1.43371527307763 0.727272727272727 26.1 26 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 5.14848659360445e-06 2.22008982506035e-05 1.43371527307763 0.727272727272727 26.1 26 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 5.14848659360445e-06 2.22008982506035e-05 1.43371527307763 0.727272727272727 26.1 26 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.25544841917518e-13 6.61786157212326e-12 1.43158176820698 0.726190476190476 26.1 26 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.25544841917518e-13 6.61786157212326e-12 1.43158176820698 0.726190476190476 26.1 26 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 4.25426577389738e-10 4.29348950089076e-09 1.43082471809158 0.725806451612903 26.1 26 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 9.90254932488948e-24 7.04566384465886e-22 1.42923491284926 0.725 26.1 26 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 5.86530411985353e-07 2.99151532707942e-06 1.42923491284926 0.725 26.1 26 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.65664437804097e-13 3.62677684608047e-12 1.42753546586609 0.724137931034483 26.1 26 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.65664437804097e-13 3.62677684608047e-12 1.42753546586609 0.724137931034483 26.1 26 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.83014165125937e-09 1.55945602978568e-08 1.42753546586609 0.724137931034483 26.1 26 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 2.27456902490826e-05 9.06641939060071e-05 1.42753546586609 0.724137931034483 26.1 26 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 2.27456902490826e-05 9.06641939060071e-05 1.42753546586609 0.724137931034483 26.1 26 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 2.27456902490826e-05 9.06641939060071e-05 1.42753546586609 0.724137931034483 26.1 26 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.24338911040847e-19 1.06411423470375e-17 1.42544383880987 0.723076923076923 26.1 26 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.54489347192959e-11 3.35313278755168e-10 1.42375891701459 0.722222222222222 26.1 26 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 7.88081345395098e-09 5.55168195295655e-08 1.42375891701459 0.722222222222222 26.1 26 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.56229784274132e-06 1.1538448829813e-05 1.42375891701459 0.722222222222222 26.1 26 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.56229784274132e-06 1.1538448829813e-05 1.42375891701459 0.722222222222222 26.1 26 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000942649545804264 0.00270987940137266 1.42375891701459 0.722222222222222 26.1 26 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000942649545804264 0.00270987940137266 1.42375891701459 0.722222222222222 26.1 26 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000942649545804264 0.00270987940137266 1.42375891701459 0.722222222222222 26.1 26 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000942649545804264 0.00270987940137266 1.42375891701459 0.722222222222222 26.1 26 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 5.09147004050901e-32 7.24516186764433e-30 1.42326779631193 0.721973094170404 26.1 26 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.1021769712457e-15 1.45207956601652e-13 1.41937812034685 0.72 26.1 26 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000101132047824902 0.00035888005998712 1.41937812034685 0.72 26.1 26 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 6.09781027425054e-16 1.928263115613e-14 1.41864116389807 0.719626168224299 26.1 26 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 6.09781027425054e-16 1.928263115613e-14 1.41864116389807 0.719626168224299 26.1 26 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.52868425961151e-12 2.58966393027046e-11 1.41841648205393 0.719512195121951 26.1 26 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 4.65897682069737e-10 4.63617064045619e-09 1.41691392222125 0.71875 26.1 26 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.09511361754265e-16 1.07423089701541e-14 1.41579383216416 0.718181818181818 26.1 26 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.09874740177615e-14 2.9500331183537e-13 1.41380256095155 0.717171717171717 26.1 26 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.34723772419384e-10 2.65088831867289e-09 1.41231653765856 0.716417910447761 26.1 26 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 4.6612261250138e-14 1.16367101331485e-12 1.41107766350272 0.715789473684211 26.1 26 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.34179912523957e-71 2.37769007760795e-68 1.40918402315805 0.714828897338403 26.1 26 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.36579596788783e-16 1.11384364239637e-14 1.40811321462981 0.714285714285714 26.1 26 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00436608083578289 0.0100390614216929 1.40811321462981 0.714285714285714 26.1 26 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00436608083578289 0.0100390614216929 1.40811321462981 0.714285714285714 26.1 26 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00436608083578289 0.0100390614216929 1.40811321462981 0.714285714285714 26.1 26 1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.047128222183662 0.0836202745228816 1.40811321462981 0.714285714285714 26.1 26 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.047128222183662 0.0836202745228816 1.40811321462981 0.714285714285714 26.1 26 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.047128222183662 0.0836202745228816 1.40811321462981 0.714285714285714 26.1 26 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000453365533035893 0.00141477884541683 1.40811321462981 0.714285714285714 26.1 26 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.82596503259949e-57 5.19669648277815e-55 1.4067910425973 0.713615023474178 26.1 26 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.42323842496981e-15 4.30908144411073e-14 1.40550559756568 0.712962962962963 26.1 26 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 5.94477623728964e-11 7.29260050488203e-10 1.40425537020617 0.712328767123288 26.1 26 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.22315945537964e-13 8.34660542361836e-12 1.4018549336759 0.711111111111111 26.1 26 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 2.74406938696631e-06 1.22407860114516e-05 1.40070209244755 0.710526315789474 26.1 26 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.52561523217589e-10 2.82988226408369e-09 1.39995023947254 0.710144927536232 26.1 26 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.19650736634485e-17 8.44764860083437e-16 1.3990286132451 0.709677419354839 26.1 26 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.19650736634485e-17 8.44764860083437e-16 1.3990286132451 0.709677419354839 26.1 26 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.19650736634485e-17 8.44764860083437e-16 1.3990286132451 0.709677419354839 26.1 26 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 2.42442688242804e-05 9.63675825054499e-05 1.3990286132451 0.709677419354839 26.1 26 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.56758383984173e-07 8.78217245706606e-07 1.39637893784123 0.708333333333333 26.1 26 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000219050154335327 0.000719880761245198 1.39637893784123 0.708333333333333 26.1 26 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.35737822986904e-06 6.50353273098871e-06 1.39437552473099 0.707317073170732 26.1 26 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.35737822986904e-06 6.50353273098871e-06 1.39437552473099 0.707317073170732 26.1 26 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 3.24799685520558e-15 9.62895734366155e-14 1.39261105079903 0.706422018348624 26.1 26 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.78975184020206e-12 5.79872781570702e-11 1.39154717681064 0.705882352941177 26.1 26 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.78975184020206e-12 5.79872781570702e-11 1.39154717681064 0.705882352941177 26.1 26 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.78975184020206e-12 5.79872781570702e-11 1.39154717681064 0.705882352941177 26.1 26 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 7.79715558520354e-08 4.80318285616651e-07 1.39154717681064 0.705882352941177 26.1 26 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00205466581917433 0.00539444549941895 1.39154717681064 0.705882352941177 26.1 26 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00205466581917433 0.00539444549941895 1.39154717681064 0.705882352941177 26.1 26 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00205466581917433 0.00539444549941895 1.39154717681064 0.705882352941177 26.1 26 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.90253351776335e-12 3.07648317701959e-11 1.38891167079395 0.704545454545455 26.1 26 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.68597231320888e-10 2.98604578257518e-09 1.38828063414207 0.704225352112676 26.1 26 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000106248042336575 0.000371476570626402 1.38725227811678 0.703703703703704 26.1 26 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000106248042336575 0.000371476570626402 1.38725227811678 0.703703703703704 26.1 26 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000106248042336575 0.000371476570626402 1.38725227811678 0.703703703703704 26.1 26 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 5.85016481662684e-06 2.51504064473112e-05 1.38527894628446 0.702702702702703 26.1 26 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.0104874300362e-12 6.00728801362265e-11 1.38221687964811 0.701149425287356 26.1 26 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 7.25397195450347e-15 2.02400041005067e-13 1.37995095033722 0.7 26.1 26 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.8799194242929e-06 1.28066416899025e-05 1.37995095033722 0.7 26.1 26 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000976372745879215 0.00277875683477225 1.37995095033722 0.7 26.1 26 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000976372745879215 0.00277875683477225 1.37995095033722 0.7 26.1 26 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000976372745879215 0.00277875683477225 1.37995095033722 0.7 26.1 26 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000976372745879215 0.00277875683477225 1.37995095033722 0.7 26.1 26 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000976372745879215 0.00277875683477225 1.37995095033722 0.7 26.1 26 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0207670274519802 0.0404814795399559 1.37995095033722 0.7 26.1 26 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0207670274519802 0.0404814795399559 1.37995095033722 0.7 26.1 26 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0207670274519802 0.0404814795399559 1.37995095033722 0.7 26.1 26 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0207670274519802 0.0404814795399559 1.37995095033722 0.7 26.1 26 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0207670274519802 0.0404814795399559 1.37995095033722 0.7 26.1 26 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0207670274519802 0.0404814795399559 1.37995095033722 0.7 26.1 26 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0207670274519802 0.0404814795399559 1.37995095033722 0.7 26.1 26 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.64916237947535e-07 9.20297280781736e-07 1.37995095033722 0.7 26.1 26 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.07940219460471e-23 7.3142348710595e-22 1.37887370525499 0.699453551912568 26.1 26 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.68220162662882e-11 2.25827633461586e-10 1.37757581961374 0.698795180722892 26.1 26 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 8.41400688414169e-12 1.22174814246262e-10 1.37536639568493 0.697674418604651 26.1 26 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.05756628507474e-08 2.67310964058396e-07 1.37291038426407 0.696428571428571 26.1 26 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 7.00488708697149e-07 3.53106213200087e-06 1.37137982642208 0.695652173913043 26.1 26 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.000467406310162145 0.00143965190337821 1.37137982642208 0.695652173913043 26.1 26 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000467406310162145 0.00143965190337821 1.37137982642208 0.695652173913043 26.1 26 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.05269442073156e-12 1.87248020087625e-11 1.36957537928205 0.694736842105263 26.1 26 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.05269442073156e-12 1.87248020087625e-11 1.36957537928205 0.694736842105263 26.1 26 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.91069202239741e-10 5.76090051224077e-09 1.36899895866787 0.694444444444444 26.1 26 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.94542127359166e-10 3.10469220171921e-09 1.366808560334 0.693333333333333 26.1 26 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.94542127359166e-10 3.10469220171921e-09 1.366808560334 0.693333333333333 26.1 26 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.94542127359166e-10 3.10469220171921e-09 1.366808560334 0.693333333333333 26.1 26 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.94542127359166e-10 3.10469220171921e-09 1.366808560334 0.693333333333333 26.1 26 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.94542127359166e-10 3.10469220171921e-09 1.366808560334 0.693333333333333 26.1 26 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 4.9709922047411e-09 3.69254139087028e-08 1.36478665417966 0.692307692307692 26.1 26 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 4.9709922047411e-09 3.69254139087028e-08 1.36478665417966 0.692307692307692 26.1 26 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.71094808428129e-07 9.47345962619565e-07 1.36478665417966 0.692307692307692 26.1 26 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000225054067484299 0.000732911583721354 1.36478665417966 0.692307692307692 26.1 26 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 6.03312432151135e-17 2.14628397737766e-15 1.36364648153624 0.691729323308271 26.1 26 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 9.84995868703313e-26 8.24499483038126e-24 1.36117610747549 0.69047619047619 26.1 26 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 2.97141451353983e-06 1.30907828259046e-05 1.36117610747549 0.69047619047619 26.1 26 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 2.97141451353983e-06 1.30907828259046e-05 1.36117610747549 0.69047619047619 26.1 26 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.22889311727409e-09 1.13552915966301e-08 1.36051502145923 0.690140845070423 26.1 26 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.89145724366368e-20 1.52390505841978e-18 1.35831408874656 0.689024390243902 26.1 26 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 4.52874154099732e-12 6.71291584670748e-11 1.35663380678313 0.688172043010753 26.1 26 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 5.28662654042229e-05 0.000194767597128936 1.35530896908119 0.6875 26.1 26 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00438812101496346 0.0100390614216929 1.35530896908119 0.6875 26.1 26 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00438812101496346 0.0100390614216929 1.35530896908119 0.6875 26.1 26 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00438812101496346 0.0100390614216929 1.35530896908119 0.6875 26.1 26 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00438812101496346 0.0100390614216929 1.35530896908119 0.6875 26.1 26 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00438812101496346 0.0100390614216929 1.35530896908119 0.6875 26.1 26 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00438812101496346 0.0100390614216929 1.35530896908119 0.6875 26.1 26 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00438812101496346 0.0100390614216929 1.35530896908119 0.6875 26.1 26 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 5.1149532075246e-09 3.69254139087028e-08 1.35347001525612 0.686567164179104 26.1 26 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.63519811223943e-26 2.49992460914447e-24 1.35306878896701 0.686363636363636 26.1 26 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 6.26987798934274e-10 6.06941250260865e-09 1.34882423717172 0.684210526315789 26.1 26 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0020648001030318 0.00540112232833501 1.34882423717172 0.684210526315789 26.1 26 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0020648001030318 0.00540112232833501 1.34882423717172 0.684210526315789 26.1 26 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.11735956951842e-10 3.2379581514049e-09 1.34751087374701 0.683544303797468 26.1 26 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.28763311845868e-08 2.72379550337799e-07 1.34709497532919 0.683333333333333 26.1 26 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.28763311845868e-08 2.72379550337799e-07 1.34709497532919 0.683333333333333 26.1 26 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.28763311845868e-08 2.72379550337799e-07 1.34709497532919 0.683333333333333 26.1 26 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.28763311845868e-08 2.72379550337799e-07 1.34709497532919 0.683333333333333 26.1 26 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.28763311845868e-08 2.72379550337799e-07 1.34709497532919 0.683333333333333 26.1 26 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.28763311845868e-08 2.72379550337799e-07 1.34709497532919 0.683333333333333 26.1 26 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.28763311845868e-08 2.72379550337799e-07 1.34709497532919 0.683333333333333 26.1 26 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.08557542044352e-15 3.35820396367637e-14 1.34480269800305 0.682170542635659 26.1 26 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 5.21574715084277e-09 3.69254139087028e-08 1.34280941337162 0.681159420289855 26.1 26 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000226105541288597 0.000732911583721354 1.33770755389832 0.678571428571429 26.1 26 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000226105541288597 0.000732911583721354 1.33770755389832 0.678571428571429 26.1 26 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000226105541288597 0.000732911583721354 1.33770755389832 0.678571428571429 26.1 26 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000226105541288597 0.000732911583721354 1.33770755389832 0.678571428571429 26.1 26 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000226105541288597 0.000732911583721354 1.33770755389832 0.678571428571429 26.1 26 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.63194389160281e-20 9.28902463100321e-19 1.33651423761474 0.677966101694915 26.1 26 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 5.31059927519517e-05 0.000194767597128936 1.33356604444353 0.676470588235294 26.1 26 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 5.31059927519517e-05 0.000194767597128936 1.33356604444353 0.676470588235294 26.1 26 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.61620346823574e-09 2.16009512811686e-08 1.33199898681198 0.675675675675676 26.1 26 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.61620346823574e-09 2.16009512811686e-08 1.33199898681198 0.675675675675676 26.1 26 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.26355350337481e-05 5.22685068401849e-05 1.33066698782517 0.675 26.1 26 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 3.03462080550191e-06 1.33279796488556e-05 1.32852420684639 0.673913043478261 26.1 26 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.49126354678384e-06 7.05005989060931e-06 1.32764960236525 0.673469387755102 26.1 26 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.41587147569139e-12 3.81976123323205e-11 1.32687591378579 0.673076923076923 26.1 26 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.78487028456082e-07 9.73130427176264e-07 1.32556864687565 0.672413793103448 26.1 26 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.78487028456082e-07 9.73130427176264e-07 1.32556864687565 0.672413793103448 26.1 26 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 4.35933294713279e-08 2.74483662998671e-07 1.32450649251117 0.671875 26.1 26 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.62611705667054e-09 2.16009512811686e-08 1.3228853095338 0.671052631578947 26.1 26 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.30314351298984e-09 1.14687835495823e-08 1.32255696867762 0.670886075949367 26.1 26 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.30314351298984e-09 1.14687835495823e-08 1.32255696867762 0.670886075949367 26.1 26 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.30314351298984e-09 1.14687835495823e-08 1.32255696867762 0.670886075949367 26.1 26 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 9.77805782670976e-12 1.37764121657505e-10 1.32081019532276 0.67 26.1 26 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 4.79403394306169e-28 5.24762330844368e-26 1.31929376570701 0.669230769230769 26.1 26 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 6.00707049592358e-13 1.12474490996043e-11 1.31423900032116 0.666666666666667 26.1 26 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.29977949175472e-09 1.14687835495823e-08 1.31423900032116 0.666666666666667 26.1 26 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.29977949175472e-09 1.14687835495823e-08 1.31423900032116 0.666666666666667 26.1 26 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.48247226885053e-06 7.03186012858101e-06 1.31423900032116 0.666666666666667 26.1 26 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 5.25761260522432e-05 0.000194767597128936 1.31423900032116 0.666666666666667 26.1 26 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 5.25761260522432e-05 0.000194767597128936 1.31423900032116 0.666666666666667 26.1 26 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00427869836591445 0.0100328840517931 1.31423900032116 0.666666666666667 26.1 26 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00427869836591445 0.0100328840517931 1.31423900032116 0.666666666666667 26.1 26 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00427869836591445 0.0100328840517931 1.31423900032116 0.666666666666667 26.1 26 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.019917407063694 0.0395844556587104 1.31423900032116 0.666666666666667 26.1 26 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.019917407063694 0.0395844556587104 1.31423900032116 0.666666666666667 26.1 26 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.019917407063694 0.0395844556587104 1.31423900032116 0.666666666666667 26.1 26 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.019917407063694 0.0395844556587104 1.31423900032116 0.666666666666667 26.1 26 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.019917407063694 0.0395844556587104 1.31423900032116 0.666666666666667 26.1 26 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0444088455261768 0.08112167802792 1.31423900032116 0.666666666666667 26.1 26 1 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0444088455261768 0.08112167802792 1.31423900032116 0.666666666666667 26.1 26 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0444088455261768 0.08112167802792 1.31423900032116 0.666666666666667 26.1 26 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0444088455261768 0.08112167802792 1.31423900032116 0.666666666666667 26.1 26 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0444088455261768 0.08112167802792 1.31423900032116 0.666666666666667 26.1 26 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0444088455261768 0.08112167802792 1.31423900032116 0.666666666666667 26.1 26 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000462666117779747 0.00143124757739256 1.31423900032116 0.666666666666667 26.1 26 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000462666117779747 0.00143124757739256 1.31423900032116 0.666666666666667 26.1 26 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000462666117779747 0.00143124757739256 1.31423900032116 0.666666666666667 26.1 26 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000462666117779747 0.00143124757739256 1.31423900032116 0.666666666666667 26.1 26 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00202238717156587 0.0053392522173251 1.31423900032116 0.666666666666667 26.1 26 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00915685286035992 0.0195355346631067 1.31423900032116 0.666666666666667 26.1 26 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00915685286035992 0.0195355346631067 1.31423900032116 0.666666666666667 26.1 26 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00915685286035992 0.0195355346631067 1.31423900032116 0.666666666666667 26.1 26 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.91527148596205e-11 4.88722046010877e-10 1.30753369929911 0.663265306122449 26.1 26 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.75528181833687e-07 9.64388427603615e-07 1.30364029870567 0.661290322580645 26.1 26 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 3.55302880615629e-07 1.83853090587651e-06 1.30310138167437 0.661016949152542 26.1 26 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 3.55302880615629e-07 1.83853090587651e-06 1.30310138167437 0.661016949152542 26.1 26 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 2.96727131300843e-06 1.30907828259046e-05 1.30109661031795 0.66 26.1 26 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.51255346817392e-05 9.87669498677208e-05 1.29821169543919 0.658536585365854 26.1 26 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.51255346817392e-05 9.87669498677208e-05 1.29821169543919 0.658536585365854 26.1 26 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.03819203692075e-08 7.24189837518736e-08 1.29694638189588 0.657894736842105 26.1 26 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.98507309881115e-52 4.70793169934712e-50 1.2957805873953 0.657303370786517 26.1 26 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.00073585571989e-21 1.23784657508235e-19 1.29546415745943 0.657142857142857 26.1 26 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 4.22226186015478e-08 2.72379550337799e-07 1.29546415745943 0.657142857142857 26.1 26 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00010553084798015 0.000371476570626402 1.29546415745943 0.657142857142857 26.1 26 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00010553084798015 0.000371476570626402 1.29546415745943 0.657142857142857 26.1 26 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00010553084798015 0.000371476570626402 1.29546415745943 0.657142857142857 26.1 26 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 7.13520228927234e-14 1.69223214293909e-12 1.294174282759 0.656488549618321 26.1 26 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 7.13520228927234e-14 1.69223214293909e-12 1.294174282759 0.656488549618321 26.1 26 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 6.70989402114924e-86 9.54817919209537e-83 1.29342526049707 0.656108597285068 26.1 26 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 7.04723573779512e-07 3.53106213200087e-06 1.29157970721217 0.655172413793103 26.1 26 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 7.04723573779512e-07 3.53106213200087e-06 1.29157970721217 0.655172413793103 26.1 26 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 7.04723573779512e-07 3.53106213200087e-06 1.29157970721217 0.655172413793103 26.1 26 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 1.42783027999568e-06 6.79532604827374e-06 1.29034374576986 0.654545454545455 26.1 26 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.73509419175178e-11 4.74557056684177e-10 1.28896517339191 0.653846153846154 26.1 26 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000931595583354043 0.00269991958271447 1.28896517339191 0.653846153846154 26.1 26 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000931595583354043 0.00269991958271447 1.28896517339191 0.653846153846154 26.1 26 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000931595583354043 0.00269991958271447 1.28896517339191 0.653846153846154 26.1 26 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000931595583354043 0.00269991958271447 1.28896517339191 0.653846153846154 26.1 26 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.04724685300849e-08 1.38067880181568e-07 1.28795422031474 0.653333333333333 26.1 26 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.98609675549596e-18 8.31239906785515e-17 1.2856685872707 0.652173913043478 26.1 26 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00194425634325898 0.00516171040383867 1.2856685872707 0.652173913043478 26.1 26 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.67882076812661e-07 9.33188262907877e-07 1.28436993213204 0.651515151515151 26.1 26 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 2.43860450580955e-05 9.66611201049299e-05 1.28367530263927 0.651162790697674 26.1 26 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00408616519488658 0.00978891089616769 1.28138302531313 0.65 26.1 26 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000209023355076096 0.00068851906081779 1.27558491207642 0.647058823529412 26.1 26 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000209023355076096 0.00068851906081779 1.27558491207642 0.647058823529412 26.1 26 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00866612220724354 0.0188273158792482 1.27558491207642 0.647058823529412 26.1 26 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00866612220724354 0.0188273158792482 1.27558491207642 0.647058823529412 26.1 26 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00866612220724354 0.0188273158792482 1.27558491207642 0.647058823529412 26.1 26 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00866612220724354 0.0188273158792482 1.27558491207642 0.647058823529412 26.1 26 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00866612220724354 0.0188273158792482 1.27558491207642 0.647058823529412 26.1 26 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00866612220724354 0.0188273158792482 1.27558491207642 0.647058823529412 26.1 26 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00866612220724354 0.0188273158792482 1.27558491207642 0.647058823529412 26.1 26 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 3.83551082006402e-15 1.113863652439e-13 1.27184419385919 0.645161290322581 26.1 26 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0186065330932695 0.0373402365188915 1.26730189316683 0.642857142857143 26.1 26 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0186065330932695 0.0373402365188915 1.26730189316683 0.642857142857143 26.1 26 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0186065330932695 0.0373402365188915 1.26730189316683 0.642857142857143 26.1 26 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0186065330932695 0.0373402365188915 1.26730189316683 0.642857142857143 26.1 26 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0186065330932695 0.0373402365188915 1.26730189316683 0.642857142857143 26.1 26 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0186065330932695 0.0373402365188915 1.26730189316683 0.642857142857143 26.1 26 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 3.1595659897059e-07 1.64690930525696e-06 1.26520023165246 0.641791044776119 26.1 26 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 3.1595659897059e-07 1.64690930525696e-06 1.26520023165246 0.641791044776119 26.1 26 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.10664794968741e-05 4.59113712071484e-05 1.26166944030831 0.64 26.1 26 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00184321638385278 0.00491179197419944 1.26166944030831 0.64 26.1 26 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.50652820049737e-07 8.47347679568285e-07 1.25947904197444 0.638888888888889 26.1 26 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000199219971391062 0.000660815895779675 1.25947904197444 0.638888888888889 26.1 26 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 6.26990212343251e-29 7.43505893470371e-27 1.25779928865092 0.638036809815951 26.1 26 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.70648631226335e-17 1.71726410829506e-15 1.25450086394292 0.636363636363636 26.1 26 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.48000747099217e-11 2.00576250592557e-10 1.25450086394292 0.636363636363636 26.1 26 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.48000747099217e-11 2.00576250592557e-10 1.25450086394292 0.636363636363636 26.1 26 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 4.55297500735523e-05 0.00017323217741889 1.25450086394292 0.636363636363636 26.1 26 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00384465148496342 0.00927277807305584 1.25450086394292 0.636363636363636 26.1 26 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00384465148496342 0.00927277807305584 1.25450086394292 0.636363636363636 26.1 26 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00384465148496342 0.00927277807305584 1.25450086394292 0.636363636363636 26.1 26 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0406538578203131 0.074838861162103 1.25450086394292 0.636363636363636 26.1 26 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0406538578203131 0.074838861162103 1.25450086394292 0.636363636363636 26.1 26 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0406538578203131 0.074838861162103 1.25450086394292 0.636363636363636 26.1 26 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0406538578203131 0.074838861162103 1.25450086394292 0.636363636363636 26.1 26 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0406538578203131 0.074838861162103 1.25450086394292 0.636363636363636 26.1 26 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0406538578203131 0.074838861162103 1.25450086394292 0.636363636363636 26.1 26 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0406538578203131 0.074838861162103 1.25450086394292 0.636363636363636 26.1 26 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.000408169452366673 0.00128501135114552 1.25450086394292 0.636363636363636 26.1 26 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000408169452366673 0.00128501135114552 1.25450086394292 0.636363636363636 26.1 26 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.70889890333925e-08 1.15798244735798e-07 1.25239245912957 0.635294117647059 26.1 26 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.70889890333925e-08 1.15798244735798e-07 1.25239245912957 0.635294117647059 26.1 26 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.22406649597829e-06 5.96522816362024e-06 1.25165619078206 0.634920634920635 26.1 26 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000188378549547788 0.000626314663566594 1.24506852662004 0.631578947368421 26.1 26 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00807395253085613 0.0177303000793338 1.24506852662004 0.631578947368421 26.1 26 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00807395253085613 0.0177303000793338 1.24506852662004 0.631578947368421 26.1 26 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 4.3100282658312e-05 0.000164428156093239 1.24281296769501 0.630434782608696 26.1 26 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00172877567483035 0.00466802236296697 1.24122572252554 0.62962962962963 26.1 26 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00172877567483035 0.00466802236296697 1.24122572252554 0.62962962962963 26.1 26 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00172877567483035 0.00466802236296697 1.24122572252554 0.62962962962963 26.1 26 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 5.49480991901741e-07 2.8126311204179e-06 1.23913962887424 0.628571428571429 26.1 26 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 8.72806780369104e-05 0.000312847367371596 1.23782975611644 0.627906976744186 26.1 26 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000176941104448124 0.000592440450893366 1.23209906280109 0.625 26.1 26 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000785021595936549 0.002312806896517 1.23209906280109 0.625 26.1 26 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.017104739269354 0.0349211534867873 1.23209906280109 0.625 26.1 26 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.017104739269354 0.0349211534867873 1.23209906280109 0.625 26.1 26 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.017104739269354 0.0349211534867873 1.23209906280109 0.625 26.1 26 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0912491457941041 0.154580398172631 1.23209906280109 0.625 26.1 26 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00160785187404095 0.00437470978348045 1.22360182788522 0.620689655172414 26.1 26 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00743980448278276 0.0164137081844959 1.2203647860125 0.619047619047619 26.1 26 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00743980448278276 0.0164137081844959 1.2203647860125 0.619047619047619 26.1 26 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00743980448278276 0.0164137081844959 1.2203647860125 0.619047619047619 26.1 26 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 9.19609468874908e-12 1.30860427420899e-10 1.21968943195273 0.618705035971223 26.1 26 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.5876446424864e-10 1.8518183002116e-09 1.21807517102937 0.617886178861789 26.1 26 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.72143220978919e-13 8.95813071270668e-12 1.21505115124032 0.616352201257862 26.1 26 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0366621277383597 0.0694676534909265 1.21314369260415 0.615384615384615 26.1 26 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0366621277383597 0.0694676534909265 1.21314369260415 0.615384615384615 26.1 26 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0366621277383597 0.0694676534909265 1.21314369260415 0.615384615384615 26.1 26 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0366621277383597 0.0694676534909265 1.21314369260415 0.615384615384615 26.1 26 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 8.71930646826865e-13 1.59071450055722e-11 1.21026439586537 0.613924050632911 26.1 26 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.62602836800203e-11 8.0588362116811e-10 1.20969726165925 0.613636363636364 26.1 26 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 7.09981288267284e-05 0.000257074649670317 1.20695418396841 0.612244897959184 26.1 26 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.603977037289e-12 2.65419661976591e-11 1.20541666271495 0.611464968152866 26.1 26 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.015560645386475 0.0319520900215785 1.20471908362773 0.611111111111111 26.1 26 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 1.53362766259684e-05 6.30737619617139e-05 1.20286281385326 0.610169491525424 26.1 26 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000308820871394623 0.000991991196375955 1.2020478661474 0.609756097560976 26.1 26 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.000142149008176241 0.000481614377701882 1.19995734811932 0.608695652173913 26.1 26 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.0125050557404e-20 3.05564096225664e-18 1.19586085507164 0.606617647058823 26.1 26 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.62747876261685e-14 1.62601763434548e-12 1.19574204127581 0.60655737704918 26.1 26 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.85722520664522e-20 1.52390505841978e-18 1.19562537213333 0.606498194945848 26.1 26 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00136479412450559 0.00379316804525675 1.19476272756469 0.606060606060606 26.1 26 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.05006574497719e-11 1.46494466186523e-10 1.19319067134421 0.605263157894737 26.1 26 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.000131077880120975 0.00044729933671978 1.19102909404105 0.604166666666667 26.1 26 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00026118971907603 0.00084088907295292 1.18281510028904 0.6 26.1 26 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0798715726374718 0.137101625890377 1.18281510028904 0.6 26.1 26 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0798715726374718 0.137101625890377 1.18281510028904 0.6 26.1 26 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0798715726374718 0.137101625890377 1.18281510028904 0.6 26.1 26 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0798715726374718 0.137101625890377 1.18281510028904 0.6 26.1 26 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0798715726374718 0.137101625890377 1.18281510028904 0.6 26.1 26 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0798715726374718 0.137101625890377 1.18281510028904 0.6 26.1 26 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0798715726374718 0.137101625890377 1.18281510028904 0.6 26.1 26 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 6.09604461217012e-08 3.77159629700786e-07 1.18281510028904 0.6 26.1 26 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00276168444809866 0.00708085940476468 1.18281510028904 0.6 26.1 26 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00617972345504823 0.0140027810135886 1.18281510028904 0.6 26.1 26 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0327810534426339 0.0625300791539785 1.18281510028904 0.6 26.1 26 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0327810534426339 0.0625300791539785 1.18281510028904 0.6 26.1 26 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.80668090944497e-09 2.29534881272425e-08 1.17958336504235 0.598360655737705 26.1 26 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.75198268208031e-10 3.0357142299227e-09 1.17714212618694 0.597122302158273 26.1 26 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.58851061697308e-09 2.16009512811686e-08 1.17645587931975 0.596774193548387 26.1 26 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000519946043264849 0.00159114670874383 1.17342767885818 0.595238095238095 26.1 26 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 5.03696384569678e-09 3.69254139087028e-08 1.1730397688817 0.59504132231405 26.1 26 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.23861306505615e-06 1.03426830895289e-05 1.17283353826129 0.594936708860759 26.1 26 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00113775742577976 0.00319954583182614 1.17215910839455 0.594594594594595 26.1 26 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.18421029339409e-05 8.78003177259828e-05 1.17049410966103 0.59375 26.1 26 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 4.53147307531903e-10 4.54104660998519e-09 1.16873396814274 0.592857142857143 26.1 26 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00558985910438951 0.0127066605519909 1.16821244472992 0.592592592592593 26.1 26 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00558985910438951 0.0127066605519909 1.16821244472992 0.592592592592593 26.1 26 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0126328032574107 0.026204779934833 1.16489365937557 0.590909090909091 26.1 26 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0126328032574107 0.026204779934833 1.16489365937557 0.590909090909091 26.1 26 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.88084703406365e-06 8.83315290254975e-06 1.16381405450127 0.590361445783133 26.1 26 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 1.80040436893589e-07 9.77853212593808e-07 1.16310151528423 0.59 26.1 26 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 7.90353980687186e-11 9.45103961779719e-10 1.16259603874564 0.58974358974359 26.1 26 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00227183288216534 0.00593177649783722 1.1596226473422 0.588235294117647 26.1 26 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0291599065009404 0.0559980390699571 1.1596226473422 0.588235294117647 26.1 26 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000430352834565203 0.00134888124137948 1.15710172854363 0.58695652173913 26.1 26 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.000430352834565203 0.00134888124137948 1.15710172854363 0.58695652173913 26.1 26 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.57587466052522e-60 7.47489880642463e-58 1.15637245373603 0.586586586586587 26.1 26 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.30387488399626e-09 1.14687835495823e-08 1.15465283599645 0.585714285714286 26.1 26 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000390198909142282 0.00123664375881841 1.14995912528101 0.583333333333333 26.1 26 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0113130251956788 0.0235701828015388 1.14995912528101 0.583333333333333 26.1 26 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0113130251956788 0.0235701828015388 1.14995912528101 0.583333333333333 26.1 26 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.06968488887958 0.121372823593197 1.14995912528101 0.583333333333333 26.1 26 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.06968488887958 0.121372823593197 1.14995912528101 0.583333333333333 26.1 26 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.06968488887958 0.121372823593197 1.14995912528101 0.583333333333333 26.1 26 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.11306095208552e-08 7.68876570299855e-08 1.14866558295786 0.582677165354331 26.1 26 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00184835801311834 0.00491628682741569 1.14131281606837 0.578947368421053 26.1 26 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0258548480629509 0.0498529116444161 1.14131281606837 0.578947368421053 26.1 26 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0258548480629509 0.0498529116444161 1.14131281606837 0.578947368421053 26.1 26 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00406179803184431 0.00974694536140716 1.13502459118645 0.575757575757576 26.1 26 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00406179803184431 0.00974694536140716 1.13502459118645 0.575757575757576 26.1 26 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000121148613306088 0.000421502388104065 1.13110733634198 0.573770491803279 26.1 26 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.57306758639629e-14 3.99727709900344e-13 1.12649057170385 0.571428571428571 26.1 26 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.57306758639629e-14 3.99727709900344e-13 1.12649057170385 0.571428571428571 26.1 26 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.57306758639629e-14 3.99727709900344e-13 1.12649057170385 0.571428571428571 26.1 26 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000619539428668481 0.00186780637075265 1.12649057170385 0.571428571428571 26.1 26 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00363638245310147 0.00910666776803486 1.12649057170385 0.571428571428571 26.1 26 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00900644200086466 0.0193014562759494 1.12649057170385 0.571428571428571 26.1 26 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0607362539318132 0.106700851043173 1.12649057170385 0.571428571428571 26.1 26 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0607362539318132 0.106700851043173 1.12649057170385 0.571428571428571 26.1 26 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0607362539318132 0.106700851043173 1.12649057170385 0.571428571428571 26.1 26 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 4.00191115119776e-11 4.95193005926471e-10 1.11915664871099 0.567708333333333 26.1 26 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.38804645020199e-08 9.4961062434492e-08 1.116643626147 0.566433566433566 26.1 26 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0202143792750343 0.0400627600395178 1.11424610896794 0.565217391304348 26.1 26 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0202143792750343 0.0400627600395178 1.11424610896794 0.565217391304348 26.1 26 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00290262036122256 0.00742882873025127 1.11204838488713 0.564102564102564 26.1 26 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.82140977666684e-39 2.87985123577434e-37 1.11062450731365 0.563380281690141 26.1 26 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.00712589049308529 0.0160293006742022 1.10888915652098 0.5625 26.1 26 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00712589049308529 0.0160293006742022 1.10888915652098 0.5625 26.1 26 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0178463183201177 0.0363829670050537 1.10396076026977 0.56 26.1 26 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0461589828940221 0.0834584168636726 1.0951991669343 0.555555555555556 26.1 26 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.149799521129013 0.231952903772128 1.0951991669343 0.555555555555556 26.1 26 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.149799521129013 0.231952903772128 1.0951991669343 0.555555555555556 26.1 26 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.149799521129013 0.231952903772128 1.0951991669343 0.555555555555556 26.1 26 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.149799521129013 0.231952903772128 1.0951991669343 0.555555555555556 26.1 26 1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.149799521129013 0.231952903772128 1.0951991669343 0.555555555555556 26.1 26 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0157470166593639 0.0322881912194161 1.0951991669343 0.555555555555556 26.1 26 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0402761102640113 0.0748210246810549 1.08424717526496 0.55 26.1 26 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0402761102640113 0.0748210246810549 1.08424717526496 0.55 26.1 26 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.88242874846516e-11 2.50345430753824e-10 1.08297806035048 0.549356223175966 26.1 26 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0122499803794197 0.0254849738010443 1.08106756478031 0.548387096774194 26.1 26 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00114417408189691 0.00320503881602224 1.07528645480822 0.545454545454545 26.1 26 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.126932830418062 0.198707830236416 1.07528645480822 0.545454545454545 26.1 26 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.126932830418062 0.198707830236416 1.07528645480822 0.545454545454545 26.1 26 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.63505964050871e-06 7.70427108756256e-06 1.07382942709168 0.544715447154472 26.1 26 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.55427498051597e-08 3.46654969178694e-07 1.07192618463695 0.54375 26.1 26 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 3.91015043644774e-09 3.05722201706876e-08 1.06781918776094 0.541666666666667 26.1 26 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.030734161368818 0.0587832145535323 1.06781918776094 0.541666666666667 26.1 26 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.030734161368818 0.0587832145535323 1.06781918776094 0.541666666666667 26.1 26 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.72790844422067e-21 3.98908904838584e-19 1.0658157746507 0.540650406504065 26.1 26 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.97039036228207e-19 2.14329257137193e-17 1.06524080407197 0.540358744394619 26.1 26 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00241372638056951 0.00629071912005571 1.06453359026014 0.54 26.1 26 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.16579300150941e-26 1.18494531510563e-24 1.0638590974606 0.539657853810264 26.1 26 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 5.92533488952231e-07 3.01133983849651e-06 1.06257621302562 0.539007092198582 26.1 26 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0268788464507029 0.0516872952693921 1.06150073102863 0.538461538461538 26.1 26 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0268788464507029 0.0516872952693921 1.06150073102863 0.538461538461538 26.1 26 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.108211443544337 0.178223245559712 1.06150073102863 0.538461538461538 26.1 26 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.108211443544337 0.178223245559712 1.06150073102863 0.538461538461538 26.1 26 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.108211443544337 0.178223245559712 1.06150073102863 0.538461538461538 26.1 26 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00653708631096694 0.01478898858586 1.05780212220971 0.536585365853659 26.1 26 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0235246028037861 0.045731570751076 1.05608491097236 0.535714285714286 26.1 26 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00508920964361665 0.0116056816071578 1.05139120025693 0.533333333333333 26.1 26 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.020603529544032 0.0404814795399559 1.05139120025693 0.533333333333333 26.1 26 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.020603529544032 0.0404814795399559 1.05139120025693 0.533333333333333 26.1 26 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0926850544908753 0.156639943634817 1.05139120025693 0.533333333333333 26.1 26 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0926850544908753 0.156639943634817 1.05139120025693 0.533333333333333 26.1 26 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 6.54068879795309e-59 2.32685003987181e-56 1.04867618101805 0.531956100710136 26.1 26 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000244111435918029 0.00078768837485568 1.04652364840389 0.530864197530864 26.1 26 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 6.05952822553839e-22 3.91941302951869e-20 1.0460974179439 0.530647985989492 26.1 26 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00396469822657968 0.00954613464707765 1.04602695943929 0.530612244897959 26.1 26 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.04225336862426e-14 2.85216642990831e-13 1.04366038260798 0.529411764705882 26.1 26 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0796847735468926 0.137101625890377 1.04366038260798 0.529411764705882 26.1 26 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0796847735468926 0.137101625890377 1.04366038260798 0.529411764705882 26.1 26 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.00309084227451338 0.00788220171439524 1.04147241534884 0.528301886792453 26.1 26 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00309084227451338 0.00788220171439524 1.04147241534884 0.528301886792453 26.1 26 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0687191327063236 0.120131849927639 1.0375571055167 0.526315789473684 26.1 26 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000442187954609099 0.00138293068001923 1.03622690409938 0.525641025641026 26.1 26 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.37008898294325e-06 6.54240477425586e-06 1.03019379702594 0.52258064516129 26.1 26 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0338472970882228 0.0644775150689973 1.01966818990435 0.517241379310345 26.1 26 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0257651681048748 0.04981499213755 1.01554831842999 0.515151515151515 26.1 26 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0257651681048748 0.04981499213755 1.01554831842999 0.515151515151515 26.1 26 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000113551297034821 0.000396037979609191 1.01331511707005 0.514018691588785 26.1 26 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000100627103630421 0.000357980921165223 1.01280803694475 0.513761467889908 26.1 26 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000764784794874269 0.00225786050436947 1.00972020756382 0.51219512195122 26.1 26 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 5.34279660827537e-08 3.34925091346954e-07 1.00777968186062 0.511210762331839 26.1 26 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00118716395726804 0.00331242021802434 0.997848129873472 0.506172839506173 26.1 26 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00118716395726804 0.00331242021802434 0.997848129873472 0.506172839506173 26.1 26 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000926661016909644 0.00269991958271447 0.997275476714291 0.505882352941176 26.1 26 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000926661016909644 0.00269991958271447 0.997275476714291 0.505882352941176 26.1 26 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.000979896045571523 0.002783217710276 0.985679250240869 0.5 26.1 26 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00125533689388815 0.00349578160470223 0.985679250240869 0.5 26.1 26 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00341263575203316 0.00867175120561283 0.985679250240869 0.5 26.1 26 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0237669208601224 0.0461396021609198 0.985679250240869 0.5 26.1 26 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.054209338878965 0.0958259493475368 0.985679250240869 0.5 26.1 26 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0625131362257838 0.109551961637057 0.985679250240869 0.5 26.1 26 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0971621551486359 0.164011562012466 0.985679250240869 0.5 26.1 26 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.113210564199763 0.179013168197303 0.985679250240869 0.5 26.1 26 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.113210564199763 0.179013168197303 0.985679250240869 0.5 26.1 26 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.155686633156861 0.239764154742655 0.985679250240869 0.5 26.1 26 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.155686633156861 0.239764154742655 0.985679250240869 0.5 26.1 26 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.155686633156861 0.239764154742655 0.985679250240869 0.5 26.1 26 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.184180771956544 0.280309345983061 0.985679250240869 0.5 26.1 26 1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.219727469620555 0.327062959487499 0.985679250240869 0.5 26.1 26 1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.219727469620555 0.327062959487499 0.985679250240869 0.5 26.1 26 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.219727469620555 0.327062959487499 0.985679250240869 0.5 26.1 26 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.219727469620555 0.327062959487499 0.985679250240869 0.5 26.1 26 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.219727469620555 0.327062959487499 0.985679250240869 0.5 26.1 26 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.219727469620555 0.327062959487499 0.985679250240869 0.5 26.1 26 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.219727469620555 0.327062959487499 0.985679250240869 0.5 26.1 26 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.132433794459185 0.206637378854628 0.985679250240869 0.5 26.1 26 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.132433794459185 0.206637378854628 0.985679250240869 0.5 26.1 26 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.132433794459185 0.206637378854628 0.985679250240869 0.5 26.1 26 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 2.16491641257632e-06 1.00347754237658e-05 0.980675802270103 0.49746192893401 26.1 26 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 1.86476129774625e-05 7.62515898474977e-05 0.979557018872913 0.496894409937888 26.1 26 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00148554213232913 0.00404966753698152 0.974604202485354 0.49438202247191 26.1 26 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 2.47605768731038e-05 9.78730580289631e-05 0.973510370608266 0.493827160493827 26.1 26 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 4.1550084359012e-05 0.000158940242050737 0.967081528538211 0.490566037735849 26.1 26 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 4.1550084359012e-05 0.000158940242050737 0.967081528538211 0.490566037735849 26.1 26 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 5.28308350333927e-05 0.000194767597128936 0.966601587332981 0.490322580645161 26.1 26 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00173989285399058 0.00468914305156931 0.964251440453024 0.489130434782609 26.1 26 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.00606245206668953 0.0137589621864421 0.958299271067511 0.486111111111111 26.1 26 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00780724641073727 0.0171976960409894 0.956688684057314 0.485294117647059 26.1 26 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0635695796131588 0.111266312164237 0.953883145394389 0.483870967741935 26.1 26 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00374743638773592 0.0091792969684365 0.950890570820603 0.482352941176471 26.1 26 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00374743638773592 0.0091792969684365 0.950890570820603 0.482352941176471 26.1 26 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00374743638773592 0.0091792969684365 0.950890570820603 0.482352941176471 26.1 26 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00374743638773592 0.0091792969684365 0.950890570820603 0.482352941176471 26.1 26 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00374743638773592 0.0091792969684365 0.950890570820603 0.482352941176471 26.1 26 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00480633930017339 0.010978203570059 0.949172611343059 0.481481481481481 26.1 26 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0191537875930932 0.0383345144092427 0.949172611343059 0.481481481481481 26.1 26 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0976537637663654 0.164256862694489 0.946252080231234 0.48 26.1 26 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0976537637663654 0.164256862694489 0.946252080231234 0.48 26.1 26 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0976537637663654 0.164256862694489 0.946252080231234 0.48 26.1 26 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.11315721432486 0.179013168197303 0.942823630665179 0.478260869565217 26.1 26 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.11315721432486 0.179013168197303 0.942823630665179 0.478260869565217 26.1 26 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00429694315661107 0.0100328840517931 0.940875647957193 0.477272727272727 26.1 26 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.07059801469505e-10 1.26955081242588e-09 0.935897469925673 0.474747474747475 26.1 26 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.31455437010016e-06 1.44681314989341e-05 0.935428935522707 0.474509803921569 26.1 26 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0249164071179943 0.0483052415925149 0.931914927500458 0.472727272727273 26.1 26 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.000563347303697156 0.00171658075623352 0.930148024875186 0.471830985915493 26.1 26 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.17932181304789 0.273206573840629 0.927698117873759 0.470588235294118 26.1 26 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.17932181304789 0.273206573840629 0.927698117873759 0.470588235294118 26.1 26 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00101889270516413 0.00288821577579395 0.920926598765191 0.467153284671533 26.1 26 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000394647137634937 0.00124796194856559 0.919161018629522 0.466257668711656 26.1 26 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00113996467795914 0.00319954583182614 0.915273589509378 0.464285714285714 26.1 26 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.110696447259334 0.179013168197303 0.915273589509378 0.464285714285714 26.1 26 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00378654063279847 0.0091792969684365 0.913993486586988 0.463636363636364 26.1 26 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00144199588924123 0.00398810127790398 0.913202834781981 0.463235294117647 26.1 26 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.071260989399919 0.123814881460421 0.90985776945311 0.461538461538462 26.1 26 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.071260989399919 0.123814881460421 0.90985776945311 0.461538461538462 26.1 26 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.249297339167008 0.367998043189473 0.90985776945311 0.461538461538462 26.1 26 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.249297339167008 0.367998043189473 0.90985776945311 0.461538461538462 26.1 26 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.249297339167008 0.367998043189473 0.90985776945311 0.461538461538462 26.1 26 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.249297339167008 0.367998043189473 0.90985776945311 0.461538461538462 26.1 26 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.249297339167008 0.367998043189473 0.90985776945311 0.461538461538462 26.1 26 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.249297339167008 0.367998043189473 0.90985776945311 0.461538461538462 26.1 26 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0018022053567663 0.00481151636525036 0.906537120659485 0.45985401459854 26.1 26 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00054421132485901 0.0016618298611038 0.905449543825914 0.459302325581395 26.1 26 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00328144148690196 0.00835329380297225 0.904885869073585 0.459016393442623 26.1 26 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0534085783112363 0.0945278693244891 0.903539312720796 0.458333333333333 26.1 26 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.147784521599009 0.230084654524497 0.903539312720796 0.458333333333333 26.1 26 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00984677886347788 0.020575574629558 0.901791654475689 0.457446808510638 26.1 26 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.297056335622631 0.424408800794181 0.896072045673517 0.454545454545455 26.1 26 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.297056335622631 0.424408800794181 0.896072045673517 0.454545454545455 26.1 26 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.297056335622631 0.424408800794181 0.896072045673517 0.454545454545455 26.1 26 1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.297056335622631 0.424408800794181 0.896072045673517 0.454545454545455 26.1 26 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.297056335622631 0.424408800794181 0.896072045673517 0.454545454545455 26.1 26 1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.297056335622631 0.424408800794181 0.896072045673517 0.454545454545455 26.1 26 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.297056335622631 0.424408800794181 0.896072045673517 0.454545454545455 26.1 26 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.107033142195798 0.176896819215587 0.896072045673517 0.454545454545455 26.1 26 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.107033142195798 0.176896819215587 0.896072045673517 0.454545454545455 26.1 26 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0789626048908106 0.137029008243443 0.891805035932215 0.452380952380952 26.1 26 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00167786321658274 0.00455648732289548 0.891506073466264 0.452229299363057 26.1 26 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.162417511147311 0.249589760650781 0.876159333547439 0.444444444444444 26.1 26 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.134144135414595 0.209076784989013 0.869716985506649 0.441176470588235 26.1 26 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0231606941335118 0.0450857287988883 0.869093532470444 0.440860215053763 26.1 26 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.271774630068808 0.391432488449305 0.86246934396076 0.4375 26.1 26 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.271774630068808 0.391432488449305 0.86246934396076 0.4375 26.1 26 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.175623647534806 0.26959271892344 0.854255350208753 0.433333333333333 26.1 26 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.0306436568571234 0.0587680912502514 0.844867928777888 0.428571428571429 26.1 26 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.319505368674618 0.454656139623982 0.844867928777888 0.428571428571429 26.1 26 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.319505368674618 0.454656139623982 0.844867928777888 0.428571428571429 26.1 26 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.18761006679268 0.285223424194427 0.836333909295283 0.424242424242424 26.1 26 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0583460553808463 0.102882821322112 0.834928306086383 0.423529411764706 26.1 26 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0583460553808463 0.102882821322112 0.834928306086383 0.423529411764706 26.1 26 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.230732000699039 0.343084260182583 0.834036288665351 0.423076923076923 26.1 26 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.28963478273187 0.416734373940799 0.830045684413363 0.421052631578947 26.1 26 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0617088844124768 0.108275884733606 0.828866642248003 0.420454545454545 26.1 26 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.213746897853279 0.321854492471843 0.826698726008471 0.419354838709677 26.1 26 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.213746897853279 0.321854492471843 0.826698726008471 0.419354838709677 26.1 26 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0809199068994903 0.138733768093945 0.82347886728984 0.417721518987342 26.1 26 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.153276333763343 0.236821088974198 0.821399375200724 0.416666666666667 26.1 26 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.153276333763343 0.236821088974198 0.821399375200724 0.416666666666667 26.1 26 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.377681738241265 0.51826529750947 0.821399375200724 0.416666666666667 26.1 26 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.377681738241265 0.51826529750947 0.821399375200724 0.416666666666667 26.1 26 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.377681738241265 0.51826529750947 0.821399375200724 0.416666666666667 26.1 26 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.377681738241265 0.51826529750947 0.821399375200724 0.416666666666667 26.1 26 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.336491601983451 0.468138342241176 0.811735853139539 0.411764705882353 26.1 26 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0512347705080347 0.0907933728928186 0.807170409646066 0.409448818897638 26.1 26 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.116703247947543 0.183096716460148 0.804106756775446 0.407894736842105 26.1 26 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.235271615174718 0.349469215442197 0.799199392087191 0.405405405405405 26.1 26 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.349961143671938 0.485374958523556 0.788543400192695 0.4 26.1 26 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.349961143671938 0.485374958523556 0.788543400192695 0.4 26.1 26 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.349961143671938 0.485374958523556 0.788543400192695 0.4 26.1 26 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.391966938131298 0.536832486006581 0.788543400192695 0.4 26.1 26 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.327191679043976 0.461440792150225 0.774462268046397 0.392857142857143 26.1 26 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0448320349040844 0.0817897252160412 0.767958933922605 0.389558232931727 26.1 26 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.162291527419986 0.249589760650781 0.767792258082361 0.389473684210526 26.1 26 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.307684355795005 0.438712262821937 0.766639416854009 0.388888888888889 26.1 26 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.402852104619762 0.551210139301847 0.766639416854009 0.388888888888889 26.1 26 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.457921987662676 0.603913798372556 0.758214807877591 0.384615384615385 26.1 26 1 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.457921987662676 0.603913798372556 0.758214807877591 0.384615384615385 26.1 26 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.351761676172571 0.487397142350116 0.745919432614711 0.378378378378378 26.1 26 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.298292280517713 0.425747156646645 0.739259437680651 0.375 26.1 26 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.326007590507526 0.460226985408938 0.731310411469032 0.370967741935484 26.1 26 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.424772819382367 0.571315427203315 0.730132777956199 0.37037037037037 26.1 26 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.369582131561505 0.509114591686372 0.728545532786729 0.369565217391304 26.1 26 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.468895542387698 0.617241773189357 0.726289973861693 0.368421052631579 26.1 26 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.468895542387698 0.617241773189357 0.726289973861693 0.368421052631579 26.1 26 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.430005735188075 0.577262416200595 0.722831450176637 0.366666666666667 26.1 26 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.430005735188075 0.577262416200595 0.722831450176637 0.366666666666667 26.1 26 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.391010832906202 0.536038935670063 0.710981754272102 0.360655737704918 26.1 26 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.442317999165606 0.589895513413925 0.707667154019085 0.358974358974359 26.1 26 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.417649587307615 0.562266189913658 0.706713424701 0.358490566037736 26.1 26 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.451420978633676 0.597000048880781 0.698189468920616 0.354166666666667 26.1 26 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.483722433976638 0.636171001431382 0.695773588405319 0.352941176470588 26.1 26 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.533677261688068 0.697503103848825 0.695773588405319 0.352941176470588 26.1 26 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.360710346448294 0.497374828484421 0.692639473142232 0.351351351351351 26.1 26 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.532937141696185 0.697503103848825 0.689975475168608 0.35 26.1 26 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.532937141696185 0.697503103848825 0.689975475168608 0.35 26.1 26 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.454286503668565 0.600231842822997 0.682393327089832 0.346153846153846 26.1 26 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.531989889749702 0.697503103848825 0.679778793269565 0.344827586206897 26.1 26 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.487926025939595 0.641106865108074 0.664492060406283 0.337073170731707 26.1 26 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.58933449072499 0.739526437655785 0.657119500160579 0.333333333333333 26.1 26 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.599089840222221 0.750444403729067 0.657119500160579 0.333333333333333 26.1 26 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.599089840222221 0.750444403729067 0.657119500160579 0.333333333333333 26.1 26 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.585854122661278 0.735807958117386 0.657119500160579 0.333333333333333 26.1 26 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.606246694918414 0.758741466023662 0.657119500160579 0.333333333333333 26.1 26 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.642606238081893 0.795847412350334 0.630834720154156 0.32 26.1 26 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.652522306555352 0.805796581612449 0.629156968238853 0.319148936170213 26.1 26 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.66542571936546 0.816998100653193 0.628549087110119 0.318840579710145 26.1 26 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.66043795637614 0.811574448983805 0.625064890396648 0.317073170731707 26.1 26 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.72775602024294 0.869518737872127 0.625064890396648 0.317073170731707 26.1 26 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.767173400105874 0.905964936390588 0.598893721665338 0.30379746835443 26.1 26 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.713283390909988 0.854379011165752 0.591407550144521 0.3 26.1 26 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.726572785730883 0.868834516046258 0.591407550144521 0.3 26.1 26 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.726572785730883 0.868834516046258 0.591407550144521 0.3 26.1 26 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.813120657496981 0.943007901889327 0.589375221793509 0.298969072164948 26.1 26 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.95076389117688 1 0.572080506022151 0.290196078431373 26.1 26 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.761142383165369 0.8995893781099 0.563245285851925 0.285714285714286 26.1 26 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.761142383165369 0.8995893781099 0.563245285851925 0.285714285714286 26.1 26 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.776169406303395 0.915069648027946 0.563245285851925 0.285714285714286 26.1 26 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.788443417707071 0.928770681620167 0.551980380134886 0.28 26.1 26 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.863538548976687 0.98971175687279 0.549394991937533 0.278688524590164 26.1 26 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.802815195176784 0.93888556484106 0.53764322740411 0.272727272727273 26.1 26 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.824088198919581 0.954172096877594 0.530750365514314 0.269230769230769 26.1 26 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.863294358056955 0.98971175687279 0.528901061104856 0.268292682926829 26.1 26 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.819921881540011 0.950121203120062 0.518778552758352 0.263157894736842 26.1 26 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.838592696988013 0.968672445803703 0.514267434908279 0.260869565217391 26.1 26 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.869061081246765 0.98971175687279 0.508737677543674 0.258064516129032 26.1 26 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.869061081246765 0.98971175687279 0.508737677543674 0.258064516129032 26.1 26 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.892751277726871 1 0.505476538585061 0.256410256410256 26.1 26 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.902669169820826 1 0.504301011751142 0.255813953488372 26.1 26 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.92567627659066 1 0.492839625120434 0.25 26.1 26 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.937844829839193 1 0.482781673587364 0.244897959183673 26.1 26 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.983837159319872 1 0.477905091025876 0.242424242424242 26.1 26 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.998064858743582 1 0.476941572697195 0.241935483870968 26.1 26 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.903186515141092 1 0.475845155288695 0.241379310344828 26.1 26 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.966357254718404 1 0.469371071543271 0.238095238095238 26.1 26 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.972921575714648 1 0.449608079057238 0.228070175438596 26.1 26 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.93705682500589 1 0.445145467850715 0.225806451612903 26.1 26 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.93705682500589 1 0.445145467850715 0.225806451612903 26.1 26 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.985105251077209 1 0.444249802925462 0.225352112676056 26.1 26 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999875612456 1 0.431869774590071 0.219072164948454 26.1 26 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.928686109194921 1 0.428556195756899 0.217391304347826 26.1 26 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999997650514255 1 0.422433964388944 0.214285714285714 26.1 26 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999981120621548 1 0.41789166369659 0.211981566820276 26.1 26 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.975089956536155 1 0.394271700096348 0.2 26.1 26 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.956933735973234 1 0.394271700096348 0.2 26.1 26 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.988167412867259 1 0.363144986930846 0.184210526315789 26.1 26 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.347594697817939 0.17632241813602 26.1 26 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999383406649 1 0.347227917698488 0.176136363636364 26.1 26 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.991098387037662 1 0.337947171511155 0.171428571428571 26.1 26 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.288752330088645 0.146473779385172 26.1 26 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999216081158012 1 0.287489781320253 0.145833333333333 26.1 26 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999986263881 1 0.21903983338686 0.111111111111111 26.1 26 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999962970503 1 0.197135850048174 0.1 26.1 26 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.000369635736318078 0.0011004009472398 0.638523956723339 1 26.3 26 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%REACT_208465.1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 EARLY STAGE PANCREATIC PRECURSOR CELLS%REACTOME%REACT_13403.1 EARLY STAGE PANCREATIC PRECURSOR CELLS 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0192375033581862 0.0353225384241277 0.638523956723339 1 26.3 26 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 4.97775766461413e-11 4.48313237768728e-10 0.638523956723339 1 26.3 26 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.58754246137038e-09 1.23446607788527e-08 0.638523956723339 1 26.3 26 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.58754246137038e-09 1.23446607788527e-08 0.638523956723339 1 26.3 26 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 1.14761779792834e-08 7.66694895047901e-08 0.638523956723339 1 26.3 26 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 5.05842297384917e-08 3.08932870892162e-07 0.638523956723339 1 26.3 26 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 8.29350360440821e-08 4.797420987428e-07 0.638523956723339 1 26.3 26 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 8.29350360440821e-08 4.797420987428e-07 0.638523956723339 1 26.3 26 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 8.29350360440821e-08 4.797420987428e-07 0.638523956723339 1 26.3 26 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 2.22925241678736e-07 1.21541233298407e-06 0.638523956723339 1 26.3 26 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 9.82267119878814e-07 4.80331997109124e-06 0.638523956723339 1 26.3 26 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 9.82267119878814e-07 4.80331997109124e-06 0.638523956723339 1 26.3 26 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 9.82267119878814e-07 4.80331997109124e-06 0.638523956723339 1 26.3 26 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.61028720619684e-06 7.58754534575533e-06 0.638523956723339 1 26.3 26 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 1.61028720619684e-06 7.58754534575533e-06 0.638523956723339 1 26.3 26 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 1.61028720619684e-06 7.58754534575533e-06 0.638523956723339 1 26.3 26 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 2.63978700627047e-06 1.18873952845661e-05 0.638523956723339 1 26.3 26 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.63978700627047e-06 1.18873952845661e-05 0.638523956723339 1 26.3 26 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 2.63978700627047e-06 1.18873952845661e-05 0.638523956723339 1 26.3 26 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 2.63978700627047e-06 1.18873952845661e-05 0.638523956723339 1 26.3 26 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 2.63978700627047e-06 1.18873952845661e-05 0.638523956723339 1 26.3 26 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 2.63978700627047e-06 1.18873952845661e-05 0.638523956723339 1 26.3 26 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 4.32739202696274e-06 1.84921286917957e-05 0.638523956723339 1 26.3 26 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 4.32739202696274e-06 1.84921286917957e-05 0.638523956723339 1 26.3 26 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 4.32739202696274e-06 1.84921286917957e-05 0.638523956723339 1 26.3 26 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 4.32739202696274e-06 1.84921286917957e-05 0.638523956723339 1 26.3 26 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.09374224922809e-06 2.91745526608427e-05 0.638523956723339 1 26.3 26 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 7.09374224922809e-06 2.91745526608427e-05 0.638523956723339 1 26.3 26 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 7.09374224922809e-06 2.91745526608427e-05 0.638523956723339 1 26.3 26 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 7.09374224922809e-06 2.91745526608427e-05 0.638523956723339 1 26.3 26 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 7.09374224922809e-06 2.91745526608427e-05 0.638523956723339 1 26.3 26 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 7.09374224922809e-06 2.91745526608427e-05 0.638523956723339 1 26.3 26 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 3.12445131738392e-05 0.000115183788203039 0.638523956723339 1 26.3 26 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 3.12445131738392e-05 0.000115183788203039 0.638523956723339 1 26.3 26 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.12141739821041e-05 0.000182194423941335 0.638523956723339 1 26.3 26 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 5.12141739821041e-05 0.000182194423941335 0.638523956723339 1 26.3 26 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 5.12141739821041e-05 0.000182194423941335 0.638523956723339 1 26.3 26 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 5.12141739821041e-05 0.000182194423941335 0.638523956723339 1 26.3 26 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 5.12141739821041e-05 0.000182194423941335 0.638523956723339 1 26.3 26 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 8.39456886083268e-05 0.000283068044762202 0.638523956723339 1 26.3 26 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 8.39456886083268e-05 0.000283068044762202 0.638523956723339 1 26.3 26 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 8.39456886083268e-05 0.000283068044762202 0.638523956723339 1 26.3 26 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 8.39456886083268e-05 0.000283068044762202 0.638523956723339 1 26.3 26 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 8.39456886083268e-05 0.000283068044762202 0.638523956723339 1 26.3 26 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 8.39456886083268e-05 0.000283068044762202 0.638523956723339 1 26.3 26 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 8.39456886083268e-05 0.000283068044762202 0.638523956723339 1 26.3 26 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000225522711836393 0.00071088548189614 0.638523956723339 1 26.3 26 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.000225522711836393 0.00071088548189614 0.638523956723339 1 26.3 26 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.000225522711836393 0.00071088548189614 0.638523956723339 1 26.3 26 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000225522711836393 0.00071088548189614 0.638523956723339 1 26.3 26 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000225522711836393 0.00071088548189614 0.638523956723339 1 26.3 26 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000225522711836393 0.00071088548189614 0.638523956723339 1 26.3 26 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.000992925659271721 0.00266089117352855 0.638523956723339 1 26.3 26 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00162733082168882 0.00410583645259431 0.638523956723339 1 26.3 26 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00266702314059111 0.00623102617705341 0.638523956723339 1 26.3 26 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00716315101440672 0.0148156451940418 0.638523956723339 1 26.3 26 3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0315252645987149 0.0551111198083185 0.638523956723339 1 26.3 26 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_217410.1 ACTIVATION OF TRKA RECEPTORS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_223937.1 FGFR2B LIGAND BINDING AND ACTIVATION 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 KLOTHO-MEDIATED LIGAND BINDING%REACTOME%REACT_222862.1 KLOTHO-MEDIATED LIGAND BINDING 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 SCAVENGING BY CLASS B RECEPTORS%REACTOME%REACT_196592.2 SCAVENGING BY CLASS B RECEPTORS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0516607365281288 0.0830657944401438 0.638523956723339 1 26.3 26 3 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%REACT_208690.1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 HEME DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605106 HEME DEGRADATION 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%REACT_209262.1 CLEAVAGE OF THE DAMAGED PYRIMIDINE 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%REACT_215995.1 NOSTRIN MEDIATED ENOS TRAFFICKING 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220836.1 FGFR1B LIGAND BINDING AND ACTIVATION 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605564 MUSCARINIC ACETYLCHOLINE RECEPTORS 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 G2 PHASE%REACTOME%REACT_227891.1 G2 PHASE 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 DEPYRIMIDINATION%REACTOME%REACT_206945.1 DEPYRIMIDINATION 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_199058.2 GRB7 EVENTS IN ERBB2 SIGNALING 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5605511 TRANSMISSION ACROSS ELECTRICAL SYNAPSES 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 GLYOXYLATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5605550 GLYOXYLATE METABOLISM 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%REACT_209347.1 NGF-INDEPENDANT TRKA ACTIVATION 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 48%5605510 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0846553225903474 0.124704476238162 0.638523956723339 1 26.3 26 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.88167563074297e-08 1.21159476133359e-07 0.638523956723338 1 26.3 26 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.88167563074297e-08 1.21159476133359e-07 0.638523956723338 1 26.3 26 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.88167563074297e-08 1.21159476133359e-07 0.638523956723338 1 26.3 26 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 3.6547490284701e-07 1.9405626371317e-06 0.638523956723338 1 26.3 26 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 5.99166714969743e-07 3.04505084072123e-06 0.638523956723338 1 26.3 26 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 5.99166714969743e-07 3.04505084072123e-06 0.638523956723338 1 26.3 26 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 1.16283040467618e-05 4.5836777447485e-05 0.638523956723338 1 26.3 26 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.16283040467618e-05 4.5836777447485e-05 0.638523956723338 1 26.3 26 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.90611528765748e-05 7.21383525089519e-05 0.638523956723338 1 26.3 26 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000137593663248281 0.000450540841443901 0.638523956723338 1 26.3 26 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000137593663248281 0.000450540841443901 0.638523956723338 1 26.3 26 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000137593663248281 0.000450540841443901 0.638523956723338 1 26.3 26 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000137593663248281 0.000450540841443901 0.638523956723338 1 26.3 26 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000137593663248281 0.000450540841443901 0.638523956723338 1 26.3 26 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000605828130059921 0.00170038151691374 0.638523956723338 1 26.3 26 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00437088656873659 0.00968811773724637 0.638523956723338 1 26.3 26 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0117389836508144 0.022945843042732 0.638523956723338 1 26.3 26 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.80384694484686e-13 3.2908643622014e-12 0.628993748414035 0.985074626865672 26.3 26 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 7.61487805455197e-13 9.4225838883717e-12 0.628547019899536 0.984375 26.3 26 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.17687979022288e-12 5.62343506983753e-11 0.627881890777949 0.983333333333333 26.3 26 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.17687979022288e-12 5.62343506983753e-11 0.627881890777949 0.983333333333333 26.3 26 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.17687979022288e-12 5.62343506983753e-11 0.627881890777949 0.983333333333333 26.3 26 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.17687979022288e-12 5.62343506983753e-11 0.627881890777949 0.983333333333333 26.3 26 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.17687979022288e-12 5.62343506983753e-11 0.627881890777949 0.983333333333333 26.3 26 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.17687979022288e-12 5.62343506983753e-11 0.627881890777949 0.983333333333333 26.3 26 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.17687979022288e-12 5.62343506983753e-11 0.627881890777949 0.983333333333333 26.3 26 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 3.50352089678497e-11 3.48637079449301e-10 0.627121743210422 0.982142857142857 26.3 26 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 9.82203454452721e-10 7.9867172324927e-09 0.625492855565719 0.979591836734694 26.3 26 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.53697884847887e-09 1.80506045069272e-08 0.624938340622842 0.978723404255319 26.3 26 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 6.5412733190004e-09 4.4967304023853e-08 0.62433453546282 0.977777777777778 26.3 26 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.5412733190004e-09 4.4967304023853e-08 0.62433453546282 0.977777777777778 26.3 26 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.04960621731434e-08 7.04523418508633e-08 0.62401204861599 0.977272727272727 26.3 26 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.04960621731434e-08 7.04523418508633e-08 0.62401204861599 0.977272727272727 26.3 26 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.68334476615119e-08 1.11413934987588e-07 0.623674562380935 0.976744186046512 26.3 26 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 8.41180244140122e-16 2.09351142914108e-14 0.623499863623966 0.976470588235294 26.3 26 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 8.41180244140122e-16 2.09351142914108e-14 0.623499863623966 0.976470588235294 26.3 26 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 2.69831616483366e-08 1.69898402768066e-07 0.623321005372783 0.976190476190476 26.3 26 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 2.69831616483366e-08 1.69898402768066e-07 0.623321005372783 0.976190476190476 26.3 26 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.46228503414018e-15 8.3505620399686e-14 0.622950201681306 0.975609756097561 26.3 26 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.32290332139824e-08 2.66298330145008e-07 0.622950201681306 0.975609756097561 26.3 26 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.32290332139824e-08 2.66298330145008e-07 0.622950201681306 0.975609756097561 26.3 26 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.42111993863941e-14 3.11115949643674e-13 0.622358793261988 0.974683544303797 26.3 26 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.42111993863941e-14 3.11115949643674e-13 0.622358793261988 0.974683544303797 26.3 26 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.27389691126607e-14 4.75846368342885e-13 0.622151547576586 0.974358974358974 26.3 26 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 9.29597472165208e-14 1.78759081471769e-12 0.621496651210716 0.973333333333333 26.3 26 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 9.29597472165208e-14 1.78759081471769e-12 0.621496651210716 0.973333333333333 26.3 26 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 9.29597472165208e-14 1.78759081471769e-12 0.621496651210716 0.973333333333333 26.3 26 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 9.29597472165208e-14 1.78759081471769e-12 0.621496651210716 0.973333333333333 26.3 26 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 9.29597472165208e-14 1.78759081471769e-12 0.621496651210716 0.973333333333333 26.3 26 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 2.83077576120696e-07 1.52583102583239e-06 0.621266552487573 0.972972972972973 26.3 26 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 2.83077576120696e-07 1.52583102583239e-06 0.621266552487573 0.972972972972973 26.3 26 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.7878751681355e-13 4.90013305841528e-12 0.62078718014769 0.972222222222222 26.3 26 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 4.5208738680876e-07 2.36514835084142e-06 0.62078718014769 0.972222222222222 26.3 26 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.5208738680876e-07 2.36514835084142e-06 0.62078718014769 0.972222222222222 26.3 26 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 4.5208738680876e-07 2.36514835084142e-06 0.62078718014769 0.972222222222222 26.3 26 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 7.21478286476683e-07 3.57722509287916e-06 0.620280415102672 0.971428571428571 26.3 26 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 7.21478286476683e-07 3.57722509287916e-06 0.620280415102672 0.971428571428571 26.3 26 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.45161229066327e-12 2.9072035746782e-11 0.619743840349123 0.970588235294118 26.3 26 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.83318846215628e-06 8.58101046594863e-06 0.61917474591354 0.96969696969697 26.3 26 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.91844415545975e-06 1.30186396025681e-05 0.618570083075734 0.96875 26.3 26 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 2.91844415545975e-06 1.30186396025681e-05 0.618570083075734 0.96875 26.3 26 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 4.64196473789523e-06 1.97769934791165e-05 0.617926409732263 0.967741935483871 26.3 26 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.50027481456537e-30 1.52492218651894e-28 0.617588745027491 0.967213114754098 26.3 26 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 7.37622926652896e-06 3.0161994960548e-05 0.61723982483256 0.966666666666667 26.3 26 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 7.37622926652896e-06 3.0161994960548e-05 0.61723982483256 0.966666666666667 26.3 26 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 1.17090784573328e-05 4.60276758143222e-05 0.61650588925012 0.96551724137931 26.3 26 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 1.85668295367836e-05 7.0454929148915e-05 0.615719529697505 0.964285714285714 26.3 26 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 1.85668295367836e-05 7.0454929148915e-05 0.615719529697505 0.964285714285714 26.3 26 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 1.85668295367836e-05 7.0454929148915e-05 0.615719529697505 0.964285714285714 26.3 26 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.00054851735232e-36 5.69278054019236e-34 0.615617267692905 0.964125560538117 26.3 26 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 2.94067818081846e-05 0.000108973569044392 0.614874921289141 0.962962962962963 26.3 26 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 2.94067818081846e-05 0.000108973569044392 0.614874921289141 0.962962962962963 26.3 26 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.51079824778233e-13 2.79203364492761e-12 0.614579308346213 0.9625 26.3 26 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 9.67292304602182e-26 6.88228474724452e-24 0.614428713073401 0.962264150943396 26.3 26 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 2.5149216879121e-09 1.79835857381855e-08 0.614428713073401 0.962264150943396 26.3 26 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.41904616605962e-25 1.56468304286493e-23 0.614121767294421 0.961783439490446 26.3 26 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 4.65175175442699e-05 0.000168006161079939 0.61396534300321 0.961538461538462 26.3 26 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.27326356751956e-09 4.35456295442943e-08 0.613483801557717 0.96078431372549 26.3 26 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.27326356751956e-09 4.35456295442943e-08 0.613483801557717 0.96078431372549 26.3 26 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.3813486705468e-24 1.35546366327524e-22 0.613319063694786 0.960526315789474 26.3 26 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 9.89675911877051e-09 6.7062324885764e-08 0.612982998454405 0.96 26.3 26 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 9.89675911877051e-09 6.7062324885764e-08 0.612982998454405 0.96 26.3 26 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 7.34861475835965e-05 0.000254430141147099 0.612982998454405 0.96 26.3 26 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 7.34861475835965e-05 0.000254430141147099 0.612982998454405 0.96 26.3 26 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 7.34861475835965e-05 0.000254430141147099 0.612982998454405 0.96 26.3 26 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 7.34861475835965e-05 0.000254430141147099 0.612982998454405 0.96 26.3 26 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 1.56010044966546e-08 1.03739389713736e-07 0.6124617544081 0.959183673469388 26.3 26 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000115923225390038 0.00038541763955613 0.611918791859866 0.958333333333333 26.3 26 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000115923225390038 0.00038541763955613 0.611918791859866 0.958333333333333 26.3 26 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 9.122542377493e-12 9.7604344384756e-11 0.611544071227986 0.957746478873239 26.3 26 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 3.86721093343681e-08 2.41361454310552e-07 0.611352724522345 0.957446808510638 26.3 26 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 5.59247411996442e-22 2.48690333522168e-20 0.611158644292338 0.957142857142857 26.3 26 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 5.59247411996442e-22 2.48690333522168e-20 0.611158644292338 0.957142857142857 26.3 26 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 8.79600057728669e-22 3.79294206711484e-20 0.610961771541036 0.956834532374101 26.3 26 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 6.08071188751729e-08 3.63565252770467e-07 0.610762045561454 0.956521739130435 26.3 26 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000182583827132461 0.000587820782826903 0.610762045561454 0.956521739130435 26.3 26 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000182583827132461 0.000587820782826903 0.610762045561454 0.956521739130435 26.3 26 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.56517303767766e-41 5.6369347029059e-39 0.610353782162015 0.955882352941177 26.3 26 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.29780117521114e-17 9.57708382107234e-16 0.609500140508641 0.954545454545455 26.3 26 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000287095079416391 0.000884277701319317 0.609500140508641 0.954545454545455 26.3 26 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000287095079416391 0.000884277701319317 0.609500140508641 0.954545454545455 26.3 26 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000287095079416391 0.000884277701319317 0.609500140508641 0.954545454545455 26.3 26 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000287095079416391 0.000884277701319317 0.609500140508641 0.954545454545455 26.3 26 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.36733377471446e-10 1.18641217159675e-09 0.609053620259184 0.953846153846154 26.3 26 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.3030162629822e-13 2.43972650292587e-12 0.608825168038532 0.953488372093023 26.3 26 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.04053810495276e-13 3.54108015042412e-12 0.608475770524593 0.952941176470588 26.3 26 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.04053810495276e-13 3.54108015042412e-12 0.608475770524593 0.952941176470588 26.3 26 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.04053810495276e-13 3.54108015042412e-12 0.608475770524593 0.952941176470588 26.3 26 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.04053810495276e-13 3.54108015042412e-12 0.608475770524593 0.952941176470588 26.3 26 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.96147746892797e-19 7.15687804688334e-18 0.608357470578929 0.952755905511811 26.3 26 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.35279576369703e-10 2.8569032166113e-09 0.608118054022227 0.952380952380952 26.3 26 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000450607390147405 0.001311276720204 0.608118054022227 0.952380952380952 26.3 26 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000450607390147405 0.001311276720204 0.608118054022227 0.952380952380952 26.3 26 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000450607390147405 0.001311276720204 0.608118054022227 0.952380952380952 26.3 26 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000450607390147405 0.001311276720204 0.608118054022227 0.952380952380952 26.3 26 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000450607390147405 0.001311276720204 0.608118054022227 0.952380952380952 26.3 26 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000450607390147405 0.001311276720204 0.608118054022227 0.952380952380952 26.3 26 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 5.24426947327132e-10 4.28884796578453e-09 0.607627636236725 0.951612903225806 26.3 26 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.22009803882147e-12 1.47135551630759e-11 0.606991909477742 0.950617283950617 26.3 26 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.22009803882147e-12 1.47135551630759e-11 0.606991909477742 0.950617283950617 26.3 26 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.22009803882147e-12 1.47135551630759e-11 0.606991909477742 0.950617283950617 26.3 26 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 9.00096886471366e-07 4.44735371336373e-06 0.606597758887172 0.95 26.3 26 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000705844466506561 0.0019352922463176 0.606597758887172 0.95 26.3 26 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000705844466506561 0.0019352922463176 0.606597758887172 0.95 26.3 26 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000705844466506561 0.0019352922463176 0.606597758887172 0.95 26.3 26 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000705844466506561 0.0019352922463176 0.606597758887172 0.95 26.3 26 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000705844466506561 0.0019352922463176 0.606597758887172 0.95 26.3 26 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000705844466506561 0.0019352922463176 0.606597758887172 0.95 26.3 26 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.97246801929263e-12 3.46706720610935e-11 0.606193629800638 0.949367088607595 26.3 26 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 1.40493294694881e-06 6.70879054868507e-06 0.605779138429834 0.948717948717949 26.3 26 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 2.19016229523315e-06 1.01188342406389e-05 0.604917432685268 0.947368421052632 26.3 26 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00110325720676745 0.00292352887379902 0.604917432685268 0.947368421052632 26.3 26 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.43100056400942e-19 8.64828450646351e-18 0.604662837806192 0.946969696969697 26.3 26 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 6.46618019358942e-14 1.33353252398228e-12 0.604194711738213 0.946236559139785 26.3 26 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 5.30112358083142e-06 2.24508894509616e-05 0.603050403572042 0.944444444444444 26.3 26 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00172031653783429 0.00429475514620737 0.603050403572042 0.944444444444444 26.3 26 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00172031653783429 0.00429475514620737 0.603050403572042 0.944444444444444 26.3 26 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00172031653783429 0.00429475514620737 0.603050403572042 0.944444444444444 26.3 26 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00172031653783429 0.00429475514620737 0.603050403572042 0.944444444444444 26.3 26 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00172031653783429 0.00429475514620737 0.603050403572042 0.944444444444444 26.3 26 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00172031653783429 0.00429475514620737 0.603050403572042 0.944444444444444 26.3 26 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.1945573538262e-22 6.07091112319529e-21 0.602606984157651 0.94375 26.3 26 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 1.27560175505996e-05 4.97309944506936e-05 0.600963723974907 0.941176470588235 26.3 26 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.27560175505996e-05 4.97309944506936e-05 0.600963723974907 0.941176470588235 26.3 26 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00267544412802504 0.00623102617705341 0.600963723974907 0.941176470588235 26.3 26 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 5.17064663004323e-12 5.62343506983753e-11 0.600058658125547 0.939759036144578 26.3 26 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 1.62144259285176e-07 9.04828552795313e-07 0.599430653250481 0.938775510204082 26.3 26 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.60268216928092e-49 6.17269454481125e-47 0.59925644066816 0.938502673796791 26.3 26 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.39541275490759e-09 1.09705654709033e-08 0.599230174771133 0.938461538461538 26.3 26 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.81175751920788e-28 3.19066526460753e-26 0.598996283211894 0.938095238095238 26.3 26 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 9.08777013860833e-18 2.87375486827548e-16 0.598925571810263 0.937984496124031 26.3 26 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 2.50158141788164e-07 1.35868334261282e-06 0.59861620942813 0.9375 26.3 26 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00414871403618757 0.00937082551348399 0.59861620942813 0.9375 26.3 26 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.85453925473636e-07 2.03903693661332e-06 0.597767108421849 0.936170212765957 26.3 26 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 5.6147287264559e-15 1.33162649629112e-13 0.597517831062207 0.935779816513762 26.3 26 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.10694312672476e-18 3.75042873649843e-17 0.597180678949885 0.935251798561151 26.3 26 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.20940736400081e-16 3.1870123684688e-15 0.596993943277918 0.934959349593496 26.3 26 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.93132975026512e-07 3.0360727462688e-06 0.596881089980512 0.934782608695652 26.3 26 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 5.93132975026512e-07 3.0360727462688e-06 0.596881089980512 0.934782608695652 26.3 26 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 5.93132975026512e-07 3.0360727462688e-06 0.596881089980512 0.934782608695652 26.3 26 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.8582022555109e-16 4.80767601744001e-15 0.596653533331644 0.934426229508197 26.3 26 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00641229106823692 0.0138252881668199 0.595955692941783 0.933333333333333 26.3 26 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00641229106823692 0.0138252881668199 0.595955692941783 0.933333333333333 26.3 26 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00641229106823692 0.0138252881668199 0.595955692941783 0.933333333333333 26.3 26 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00641229106823692 0.0138252881668199 0.595955692941783 0.933333333333333 26.3 26 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00641229106823692 0.0138252881668199 0.595955692941783 0.933333333333333 26.3 26 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00641229106823692 0.0138252881668199 0.595955692941783 0.933333333333333 26.3 26 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.4466866730447e-12 3.98750824044115e-11 0.595477397843113 0.932584269662921 26.3 26 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.84663120825256e-08 1.20539275657954e-07 0.595234196945485 0.932203389830508 26.3 26 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.84663120825256e-08 1.20539275657954e-07 0.595234196945485 0.932203389830508 26.3 26 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 5.28160996497860e-12 5.69373559103375e-11 0.594988232401293 0.931818181818182 26.3 26 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.39854695634507e-06 6.70078221844792e-06 0.594988232401293 0.931818181818182 26.3 26 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.39854695634507e-06 6.70078221844792e-06 0.594988232401293 0.931818181818182 26.3 26 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.04085467104224e-20 4.11426721359195e-19 0.594625434698609 0.93125 26.3 26 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.20451904449353e-17 1.45216286280672e-15 0.594318452027107 0.930769230769231 26.3 26 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 5.2909043577418e-22 2.48690333522168e-20 0.593975773696129 0.930232558139535 26.3 26 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.23719905477117e-11 1.31383153353685e-10 0.593975773696129 0.930232558139535 26.3 26 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.63446390169662e-13 4.35911875827243e-12 0.593827279752705 0.93 26.3 26 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.63446390169662e-13 4.35911875827243e-12 0.593827279752705 0.93 26.3 26 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.89117722297529e-11 1.90861360871904e-10 0.59345167742522 0.929411764705882 26.3 26 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.89117722297529e-11 1.90861360871904e-10 0.59345167742522 0.929411764705882 26.3 26 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.89117722297529e-11 1.90861360871904e-10 0.59345167742522 0.929411764705882 26.3 26 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.89117722297529e-11 1.90861360871904e-10 0.59345167742522 0.929411764705882 26.3 26 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.89117722297529e-11 1.90861360871904e-10 0.59345167742522 0.929411764705882 26.3 26 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.89117722297529e-11 1.90861360871904e-10 0.59345167742522 0.929411764705882 26.3 26 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 4.02608597512849e-13 5.16136967802509e-12 0.593375798167143 0.929292929292929 26.3 26 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 6.1482089319135e-13 7.74239053992293e-12 0.592915102671672 0.928571428571429 26.3 26 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 3.2777337134656e-06 1.45756721070673e-05 0.592915102671671 0.928571428571429 26.3 26 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.000170326161336396 0.00055085028995839 0.592915102671671 0.928571428571429 26.3 26 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000170326161336396 0.00055085028995839 0.592915102671671 0.928571428571429 26.3 26 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00987459793311108 0.0199879841519446 0.592915102671671 0.928571428571429 26.3 26 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00987459793311108 0.0199879841519446 0.592915102671671 0.928571428571429 26.3 26 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00987459793311108 0.0199879841519446 0.592915102671671 0.928571428571429 26.3 26 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00987459793311108 0.0199879841519446 0.592915102671671 0.928571428571429 26.3 26 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00987459793311108 0.0199879841519446 0.592915102671671 0.928571428571429 26.3 26 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00987459793311108 0.0199879841519446 0.592915102671671 0.928571428571429 26.3 26 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.09276585479264e-09 1.50404333907572e-08 0.592254104786865 0.927536231884058 26.3 26 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.0100140554953e-07 5.79536290713633e-07 0.592085850779823 0.927272727272727 26.3 26 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 5.00565186301384e-06 2.12628137345334e-05 0.591802691597241 0.926829268292683 26.3 26 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.02346973569373e-10 9.10248396182611e-10 0.591225885854943 0.925925925925926 26.3 26 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.53966551957489e-07 8.63739621166733e-07 0.591225885854943 0.925925925925926 26.3 26 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000260401714245334 0.000810835097092144 0.591225885854943 0.925925925925926 26.3 26 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000260401714245334 0.000810835097092144 0.591225885854943 0.925925925925926 26.3 26 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.000260401714245334 0.000810835097092144 0.591225885854943 0.925925925925926 26.3 26 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000260401714245334 0.000810835097092144 0.591225885854943 0.925925925925926 26.3 26 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 4.85802636584667e-09 3.40540468896543e-08 0.590872915176821 0.925373134328358 26.3 26 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 4.85802636584667e-09 3.40540468896543e-08 0.590872915176821 0.925373134328358 26.3 26 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.08317717833562e-13 2.05514816636212e-12 0.590783847809444 0.925233644859813 26.3 26 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 7.63124435950399e-06 3.08165810274576e-05 0.590634659969088 0.925 26.3 26 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 7.63124435950399e-06 3.08165810274576e-05 0.590634659969088 0.925 26.3 26 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 7.63124435950399e-06 3.08165810274576e-05 0.590634659969088 0.925 26.3 26 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.36765692369097e-10 2.04192472873469e-09 0.590028466339287 0.924050632911392 26.3 26 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 9.78126837231517e-21 3.97678425537271e-19 0.589695654150377 0.923529411764706 26.3 26 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.24226564346723e-22 1.5909462105703e-20 0.589675129433028 0.923497267759563 26.3 26 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.48529439731515e-20 5.71236196589041e-19 0.589406729283082 0.923076923076923 26.3 26 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 3.56300494834554e-07 1.9132664307531e-06 0.589406729283082 0.923076923076923 26.3 26 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000397109708055519 0.00117481728599377 0.589406729283082 0.923076923076923 26.3 26 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000397109708055519 0.00117481728599377 0.589406729283082 0.923076923076923 26.3 26 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0151433309674186 0.0289519319522884 0.589406729283082 0.923076923076923 26.3 26 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 1.16129144746453e-05 4.5836777447485e-05 0.589406729283082 0.923076923076923 26.3 26 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 1.16129144746453e-05 4.5836777447485e-05 0.589406729283082 0.923076923076923 26.3 26 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.76658643767634e-11 1.8621129635655e-10 0.588860982311523 0.922222222222222 26.3 26 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.80175822297968e-19 6.74711039815813e-18 0.587598733180986 0.920245398773006 26.3 26 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.25180526607175e-09 1.0063948551526e-08 0.587442040185471 0.92 26.3 26 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.000603949620164116 0.00170038151691374 0.587442040185471 0.92 26.3 26 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000603949620164116 0.00170038151691374 0.587442040185471 0.92 26.3 26 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.000603949620164116 0.00170038151691374 0.587442040185471 0.92 26.3 26 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.000603949620164116 0.00170038151691374 0.587442040185471 0.92 26.3 26 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.90760776589621e-08 2.42817722745428e-07 0.58703008924565 0.919354838709677 26.3 26 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.74070213803598e-24 1.03209130934383e-22 0.586833922131449 0.919047619047619 26.3 26 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.67365879932893e-05 9.95972898284048e-05 0.586751744016041 0.918918918918919 26.3 26 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.67365879932893e-05 9.95972898284048e-05 0.586751744016041 0.918918918918919 26.3 26 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.99968047256123e-25 1.35502157735935e-23 0.586281087536884 0.918181818181818 26.3 26 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.27083644167623e-13 3.89325332109069e-12 0.586281087536884 0.918181818181818 26.3 26 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 5.90674411355449e-08 3.54653876522702e-07 0.586185927483721 0.918032786885246 26.3 26 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.85973182889614e-09 2.02457631468617e-08 0.58604253562279 0.917808219178082 26.3 26 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.42097319007861e-18 4.70242988251596e-17 0.58598717547395 0.917721518987342 26.3 26 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 3.42714824644661e-13 4.90013305841528e-12 0.585801795159026 0.917431192660551 26.3 26 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.7074741343877e-14 3.62647118393089e-13 0.585753381787525 0.917355371900826 26.3 26 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.7074741343877e-14 3.62647118393089e-13 0.585753381787525 0.917355371900826 26.3 26 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 8.53293484822083e-16 2.09351142914108e-14 0.585713704663514 0.917293233082707 26.3 26 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 1.87370754601383e-06 8.71335241169178e-06 0.585313626996394 0.916666666666667 26.3 26 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 1.87370754601383e-06 8.71335241169178e-06 0.585313626996394 0.916666666666667 26.3 26 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000915850446299104 0.00250144949152327 0.585313626996394 0.916666666666667 26.3 26 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0231133842783369 0.0417390175483165 0.585313626996394 0.916666666666667 26.3 26 3 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.0231133842783369 0.0417390175483165 0.585313626996394 0.916666666666667 26.3 26 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0231133842783369 0.0417390175483165 0.585313626996394 0.916666666666667 26.3 26 3 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0231133842783369 0.0417390175483165 0.585313626996394 0.916666666666667 26.3 26 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0231133842783369 0.0417390175483165 0.585313626996394 0.916666666666667 26.3 26 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0231133842783369 0.0417390175483165 0.585313626996394 0.916666666666667 26.3 26 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.23324428165637e-18 1.0456605938175e-16 0.585313626996394 0.916666666666667 26.3 26 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 9.71196785447095e-17 2.6075717465872e-15 0.584941526788513 0.916083916083916 26.3 26 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 4.52487415885488e-28 3.5771644044725e-26 0.58467253868643 0.91566265060241 26.3 26 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.18208085365452e-10 2.72777171972915e-09 0.58467253868643 0.91566265060241 26.3 26 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 1.34408252588424e-07 7.62003758698515e-07 0.584411757001022 0.915254237288136 26.3 26 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 4.78984017013321e-10 3.96275730354625e-09 0.584015814076224 0.914634146341463 26.3 26 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.18190469904706e-21 1.33172070198352e-19 0.583890890907438 0.914438502673797 26.3 26 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.76343939176572e-12 2.10871786090976e-11 0.583793331861338 0.914285714285714 26.3 26 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 6.10382096062257e-05 0.000213934414457289 0.583793331861338 0.914285714285714 26.3 26 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 6.10382096062257e-05 0.000213934414457289 0.583793331861338 0.914285714285714 26.3 26 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 6.10382096062257e-05 0.000213934414457289 0.583793331861338 0.914285714285714 26.3 26 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.65029218201957e-12 3.11683121901971e-11 0.58326707585305 0.913461538461538 26.3 26 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 9.92692417810946e-15 2.24222430245234e-13 0.583218732125254 0.913385826771654 26.3 26 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 5.33899118556192e-11 4.77822921827334e-10 0.58300013439957 0.91304347826087 26.3 26 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00138446322839767 0.00362816054145466 0.58300013439957 0.91304347826087 26.3 26 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00138446322839767 0.00362816054145466 0.58300013439957 0.91304347826087 26.3 26 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00138446322839767 0.00362816054145466 0.58300013439957 0.91304347826087 26.3 26 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.30533495616239e-28 2.05030727663693e-26 0.582039145167043 0.911538461538462 26.3 26 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 6.83618016037075e-07 3.41329276077459e-06 0.580476324293944 0.909090909090909 26.3 26 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000138043434202067 0.000450540841443901 0.580476324293944 0.909090909090909 26.3 26 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.000138043434202067 0.000450540841443901 0.580476324293944 0.909090909090909 26.3 26 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00208573049745755 0.00512606994452866 0.580476324293944 0.909090909090909 26.3 26 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00208573049745755 0.00512606994452866 0.580476324293944 0.909090909090909 26.3 26 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.00208573049745755 0.00512606994452866 0.580476324293944 0.909090909090909 26.3 26 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0350857954711081 0.0597213958796493 0.580476324293944 0.909090909090909 26.3 26 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.02529365850451e-10 3.38934489707214e-09 0.579809110128089 0.908045977011494 26.3 26 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.02529365850451e-10 3.38934489707214e-09 0.579809110128089 0.908045977011494 26.3 26 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.51019261632589e-13 4.25238582503778e-12 0.579500733832946 0.907563025210084 26.3 26 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 1.43439677912922e-05 5.53156264688586e-05 0.579126379353726 0.906976744186046 26.3 26 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 1.52668794516871e-06 7.26580918386313e-06 0.578285847598495 0.905660377358491 26.3 26 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.65040599000473e-07 9.10282063479355e-07 0.577712151321116 0.904761904761905 26.3 26 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.65040599000473e-07 9.10282063479355e-07 0.577712151321116 0.904761904761905 26.3 26 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 1.65040599000473e-07 9.10282063479355e-07 0.577712151321116 0.904761904761905 26.3 26 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.3350281985381e-09 1.05852833119137e-08 0.577712151321116 0.904761904761905 26.3 26 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.3350281985381e-09 1.05852833119137e-08 0.577712151321116 0.904761904761905 26.3 26 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 2.14208742837221e-05 8.08538570443942e-05 0.577712151321116 0.904761904761905 26.3 26 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00313059669191853 0.00722016060388991 0.577712151321116 0.904761904761905 26.3 26 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00313059669191853 0.00722016060388991 0.577712151321116 0.904761904761905 26.3 26 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00313059669191853 0.00722016060388991 0.577712151321116 0.904761904761905 26.3 26 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.80349910648769e-08 1.18813853172777e-07 0.577295632106032 0.904109589041096 26.3 26 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.32984092780368e-43 9.48045455033079e-41 0.577069773095036 0.903755868544601 26.3 26 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.000308930720966035 0.00094743193089368 0.576731315750112 0.903225806451613 26.3 26 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.000308930720966035 0.00094743193089368 0.576731315750112 0.903225806451613 26.3 26 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.68185390484528e-08 1.69898402768066e-07 0.576445238708569 0.902777777777778 26.3 26 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.68185390484528e-08 1.69898402768066e-07 0.576445238708569 0.902777777777778 26.3 26 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.06096497278485e-13 4.90013305841528e-12 0.576228936555208 0.902439024390244 26.3 26 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 3.19179749520377e-05 0.000116161837229539 0.576228936555208 0.902439024390244 26.3 26 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 3.19179749520377e-05 0.000116161837229539 0.576228936555208 0.902439024390244 26.3 26 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 3.19179749520377e-05 0.000116161837229539 0.576228936555208 0.902439024390244 26.3 26 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 3.19179749520377e-05 0.000116161837229539 0.576228936555208 0.902439024390244 26.3 26 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 3.19179749520377e-05 0.000116161837229539 0.576228936555208 0.902439024390244 26.3 26 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.65056289012125e-07 1.9405626371317e-06 0.575718321635797 0.901639344262295 26.3 26 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.65056289012125e-07 1.9405626371317e-06 0.575718321635797 0.901639344262295 26.3 26 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.01018754842431e-22 5.32406252373255e-21 0.575530561889646 0.901345291479821 26.3 26 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 9.17163835744825e-52 3.26281034566222e-49 0.575399915374263 0.901140684410646 26.3 26 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 5.90510805770306e-08 3.54653876522702e-07 0.574671561051005 0.9 26.3 26 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 5.90510805770306e-08 3.54653876522702e-07 0.574671561051005 0.9 26.3 26 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 5.41600182134237e-07 2.80253476064371e-06 0.574671561051005 0.9 26.3 26 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 5.41600182134237e-07 2.80253476064371e-06 0.574671561051005 0.9 26.3 26 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.74479455109173e-05 0.000170932725220343 0.574671561051005 0.9 26.3 26 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000460143986936415 0.00133357412099902 0.574671561051005 0.9 26.3 26 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.000460143986936415 0.00133357412099902 0.574671561051005 0.9 26.3 26 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00467997186911544 0.0102141103830541 0.574671561051005 0.9 26.3 26 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00467997186911544 0.0102141103830541 0.574671561051005 0.9 26.3 26 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00467997186911544 0.0102141103830541 0.574671561051005 0.9 26.3 26 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00467997186911544 0.0102141103830541 0.574671561051005 0.9 26.3 26 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00467997186911544 0.0102141103830541 0.574671561051005 0.9 26.3 26 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0529214773784835 0.0840482838276585 0.574671561051005 0.9 26.3 26 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 9.61139904529589e-09 6.57549078916156e-08 0.573863302877937 0.89873417721519 26.3 26 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.34275559074934e-28 1.27382747042421e-26 0.573146077195352 0.897610921501707 26.3 26 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.87982501461122e-11 2.88590915196603e-10 0.572881306966734 0.897196261682243 26.3 26 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.18595116420598e-06 5.74016498865683e-06 0.572469754303683 0.896551724137931 26.3 26 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.18595116420598e-06 5.74016498865683e-06 0.572469754303683 0.896551724137931 26.3 26 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000683216827303954 0.00190257836644526 0.572469754303683 0.896551724137931 26.3 26 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.000683216827303954 0.00190257836644526 0.572469754303683 0.896551724137931 26.3 26 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.000683216827303954 0.00190257836644526 0.572469754303683 0.896551724137931 26.3 26 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000683216827303954 0.00190257836644526 0.572469754303683 0.896551724137931 26.3 26 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 5.86088505521132e-19 2.03415595940627e-17 0.572011044564657 0.895833333333333 26.3 26 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.90780944824157e-07 1.04819028758601e-06 0.571812498558214 0.895522388059702 26.3 26 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 3.09213299453513e-08 1.93837235736718e-07 0.571310908647198 0.894736842105263 26.3 26 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 1.75018783477382e-06 8.219529006215e-06 0.571310908647198 0.894736842105263 26.3 26 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.00696532085190248 0.0148156451940418 0.571310908647198 0.894736842105263 26.3 26 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.57799500472702e-06 1.18338286829889e-05 0.570110675645838 0.892857142857143 26.3 26 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0010110313218198 0.00269924497363899 0.570110675645838 0.892857142857143 26.3 26 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0010110313218198 0.00269924497363899 0.570110675645838 0.892857142857143 26.3 26 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.10805339017026e-24 6.85547814874902e-23 0.570023302362214 0.89272030651341 26.3 26 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.57263656464847e-17 1.01677236629896e-15 0.569981837075071 0.892655367231638 26.3 26 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 6.69024773238155e-08 3.95029980214894e-07 0.569494339780275 0.891891891891892 26.3 26 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 6.69024773238155e-08 3.95029980214894e-07 0.569494339780275 0.891891891891892 26.3 26 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.39204303258546e-05 8.98120642577603e-05 0.569119178818628 0.891304347826087 26.3 26 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 4.81166658117106e-11 4.36114748089581e-10 0.568866797808065 0.890909090909091 26.3 26 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.78991935856624e-06 1.65431142553367e-05 0.568866797808065 0.890909090909091 26.3 26 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.78991935856624e-06 1.65431142553367e-05 0.568866797808065 0.890909090909091 26.3 26 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.78991935856624e-06 1.65431142553367e-05 0.568866797808065 0.890909090909091 26.3 26 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.78991935856624e-06 1.65431142553367e-05 0.568866797808065 0.890909090909091 26.3 26 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.78991935856624e-06 1.65431142553367e-05 0.568866797808065 0.890909090909091 26.3 26 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.78991935856624e-06 1.65431142553367e-05 0.568866797808065 0.890909090909091 26.3 26 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 6.07450943203559e-07 3.05442647412955e-06 0.568685398956723 0.890625 26.3 26 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 6.07450943203559e-07 3.05442647412955e-06 0.568685398956723 0.890625 26.3 26 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 6.07450943203559e-07 3.05442647412955e-06 0.568685398956723 0.890625 26.3 26 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 9.81848664150083e-08 5.65656133233024e-07 0.568548728589274 0.89041095890411 26.3 26 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 5.98603835420659e-15 1.39641517672721e-13 0.568492296953682 0.890322580645161 26.3 26 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 4.28357508660498e-10 3.58560432249346e-09 0.568286321483771 0.89 26.3 26 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 6.4879857263956e-48 1.31891481266585e-45 0.567975429669636 0.889513108614232 26.3 26 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 5.56029347928739e-06 2.34786279555667e-05 0.567576850420745 0.888888888888889 26.3 26 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00149077365853702 0.00383611377232944 0.567576850420745 0.888888888888889 26.3 26 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00149077365853702 0.00383611377232944 0.567576850420745 0.888888888888889 26.3 26 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00149077365853702 0.00383611377232944 0.567576850420745 0.888888888888889 26.3 26 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00149077365853702 0.00383611377232944 0.567576850420745 0.888888888888889 26.3 26 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00149077365853702 0.00383611377232944 0.567576850420745 0.888888888888889 26.3 26 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00149077365853702 0.00383611377232944 0.567576850420745 0.888888888888889 26.3 26 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00149077365853702 0.00383611377232944 0.567576850420745 0.888888888888889 26.3 26 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.43867614339762e-07 8.12395298434452e-07 0.567576850420745 0.888888888888889 26.3 26 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000225804805212267 0.00071088548189614 0.567576850420745 0.888888888888889 26.3 26 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0103164648495511 0.0207642566915292 0.567576850420745 0.888888888888889 26.3 26 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0103164648495511 0.0207642566915292 0.567576850420745 0.888888888888889 26.3 26 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0103164648495511 0.0207642566915292 0.567576850420745 0.888888888888889 26.3 26 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0103164648495511 0.0207642566915292 0.567576850420745 0.888888888888889 26.3 26 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0792256610171606 0.122143137191137 0.567576850420745 0.888888888888889 26.3 26 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.10464404234687e-07 1.151887873946e-06 0.566577595402399 0.887323943661972 26.3 26 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.30322105785491e-06 6.28638496721201e-06 0.566432542254575 0.887096774193548 26.3 26 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 8.14053569876951e-06 3.24481296900532e-05 0.566238225773527 0.886792452830189 26.3 26 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 8.14053569876951e-06 3.24481296900532e-05 0.566238225773527 0.886792452830189 26.3 26 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 1.33896767121888e-09 1.05852833119137e-08 0.566114023486671 0.88659793814433 26.3 26 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.000331138106016669 0.00101117923790069 0.565549790240671 0.885714285714286 26.3 26 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.000331138106016669 0.00101117923790069 0.565549790240671 0.885714285714286 26.3 26 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.68258810211902e-10 3.8966800405353e-09 0.564848115562953 0.884615384615385 26.3 26 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 1.18921848000869e-05 4.66186748499276e-05 0.564848115562953 0.884615384615385 26.3 26 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00218972227966335 0.00533557329445368 0.564848115562953 0.884615384615385 26.3 26 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00218972227966335 0.00533557329445368 0.564848115562953 0.884615384615385 26.3 26 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00218972227966335 0.00533557329445368 0.564848115562953 0.884615384615385 26.3 26 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 7.52053636261891e-05 0.000258495730531563 0.564276985011322 0.883720930232558 26.3 26 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 7.52053636261891e-05 0.000258495730531563 0.564276985011322 0.883720930232558 26.3 26 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.000484068421747639 0.00139721980557179 0.563403491226475 0.882352941176471 26.3 26 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000484068421747639 0.00139721980557179 0.563403491226475 0.882352941176471 26.3 26 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0151982383474065 0.0289519319522884 0.563403491226475 0.882352941176471 26.3 26 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0151982383474065 0.0289519319522884 0.563403491226475 0.882352941176471 26.3 26 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0151982383474065 0.0289519319522884 0.563403491226475 0.882352941176471 26.3 26 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0151982383474065 0.0289519319522884 0.563403491226475 0.882352941176471 26.3 26 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0151982383474065 0.0289519319522884 0.563403491226475 0.882352941176471 26.3 26 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.73335546301033e-05 6.66639141584782e-05 0.563403491226475 0.882352941176471 26.3 26 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 1.54174183960893e-07 8.63739621166733e-07 0.56290927763768 0.881578947368421 26.3 26 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.03703837987014e-06 1.75143463858391e-05 0.562766877112095 0.88135593220339 26.3 26 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 7.60317703797177e-17 2.08063863942958e-15 0.562034107740855 0.880208333333333 26.3 26 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00320312317128899 0.00737547616948904 0.561901081916538 0.88 26.3 26 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 5.86105500605379e-06 2.46025996271815e-05 0.561460720567073 0.879310344827586 26.3 26 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 5.86105500605379e-06 2.46025996271815e-05 0.561460720567073 0.879310344827586 26.3 26 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.000705256631440617 0.0019352922463176 0.561127113484146 0.878787878787879 26.3 26 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.000705256631440617 0.0019352922463176 0.561127113484146 0.878787878787879 26.3 26 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000159263733534852 0.000517425326073275 0.560655181513175 0.878048780487805 26.3 26 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 5.29025276115672e-05 0.000186799743898909 0.558708462132921 0.875 26.3 26 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00102386992459625 0.00272840243951398 0.558708462132921 0.875 26.3 26 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00466475270308764 0.0102141103830541 0.558708462132921 0.875 26.3 26 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00466475270308764 0.0102141103830541 0.558708462132921 0.875 26.3 26 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00466475270308764 0.0102141103830541 0.558708462132921 0.875 26.3 26 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00466475270308764 0.0102141103830541 0.558708462132921 0.875 26.3 26 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0222573302925825 0.0405015102382927 0.558708462132921 0.875 26.3 26 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0222573302925825 0.0405015102382927 0.558708462132921 0.875 26.3 26 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0222573302925825 0.0405015102382927 0.558708462132921 0.875 26.3 26 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0222573302925825 0.0405015102382927 0.558708462132921 0.875 26.3 26 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0222573302925825 0.0405015102382927 0.558708462132921 0.875 26.3 26 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 48%5605118 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 THYROXINE BIOSYNTHESIS%REACTOME%REACT_219697.1 THYROXINE BIOSYNTHESIS 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.117539593282415 0.168777841817232 0.558708462132921 0.875 26.3 26 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 4.3332037630134e-11 4.28204788525561e-10 0.558079993671579 0.874015748031496 26.3 26 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.28403110154145e-10 1.12096702913711e-09 0.556133768759037 0.870967741935484 26.3 26 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.28403110154145e-10 1.12096702913711e-09 0.556133768759037 0.870967741935484 26.3 26 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.28403110154145e-10 1.12096702913711e-09 0.556133768759037 0.870967741935484 26.3 26 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00148083353223647 0.00383611377232944 0.556133768759037 0.870967741935484 26.3 26 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00148083353223647 0.00383611377232944 0.556133768759037 0.870967741935484 26.3 26 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.54650191724356e-05 9.53597954799366e-05 0.555752332703646 0.87037037037037 26.3 26 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.01283657429411e-06 9.32985812775414e-06 0.555238223237686 0.869565217391304 26.3 26 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 6.29458417451658e-15 1.44470859360276e-13 0.555238223237686 0.869565217391304 26.3 26 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000109864888757251 0.000366989992257204 0.555238223237686 0.869565217391304 26.3 26 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00676084562452339 0.0145108345757116 0.555238223237686 0.869565217391304 26.3 26 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.09411769829565e-09 8.84619025383359e-09 0.554507646628162 0.868421052631579 26.3 26 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 6.82789657576326e-07 3.41329276077459e-06 0.554507646628162 0.868421052631579 26.3 26 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.00213319028969298 0.00523367203833294 0.553387429160227 0.866666666666667 26.3 26 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0323795925547931 0.0562590478699274 0.553387429160227 0.866666666666667 26.3 26 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0323795925547931 0.0562590478699274 0.553387429160227 0.866666666666667 26.3 26 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0323795925547931 0.0562590478699274 0.553387429160227 0.866666666666667 26.3 26 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0323795925547931 0.0562590478699274 0.553387429160227 0.866666666666667 26.3 26 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.12228021491403e-06 1.78298016590354e-05 0.552752081939606 0.865671641791045 26.3 26 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 5.23137892516365e-05 0.000185180403246464 0.552568808702889 0.865384615384615 26.3 26 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 5.23137892516365e-05 0.000185180403246464 0.552568808702889 0.865384615384615 26.3 26 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0097480825901714 0.0199017525477961 0.551452508079247 0.863636363636364 26.3 26 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0097480825901714 0.0199017525477961 0.551452508079247 0.863636363636364 26.3 26 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0097480825901714 0.0199017525477961 0.551452508079247 0.863636363636364 26.3 26 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 7.46852239106063e-05 0.000257954062196099 0.550883413643665 0.862745098039216 26.3 26 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 7.8111035822763e-08 4.57415654221365e-07 0.550217452070111 0.861702127659574 26.3 26 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.000106328297460132 0.000356851809636244 0.549130602782071 0.86 26.3 26 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000106328297460132 0.000356851809636244 0.549130602782071 0.86 26.3 26 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.75027035859359e-34 2.07552893356556e-32 0.548227639610947 0.858585858585859 26.3 26 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.35981990190893e-08 3.2594118463318e-07 0.548227639610947 0.858585858585859 26.3 26 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.81815780642579e-53 8.62412852847967e-51 0.547773432784426 0.857874519846351 26.3 26 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00140165031613346 0.0036664492644447 0.547306248620004 0.857142857142857 26.3 26 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0467557291732637 0.0782745913100638 0.547306248620004 0.857142857142857 26.3 26 3 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.0467557291732637 0.0782745913100638 0.547306248620004 0.857142857142857 26.3 26 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0467557291732637 0.0782745913100638 0.547306248620004 0.857142857142857 26.3 26 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.0467557291732637 0.0782745913100638 0.547306248620004 0.857142857142857 26.3 26 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0467557291732637 0.0782745913100638 0.547306248620004 0.857142857142857 26.3 26 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0467557291732637 0.0782745913100638 0.547306248620004 0.857142857142857 26.3 26 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%REACT_198593.2 HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.172473568104613 0.22851944824289 0.547306248620004 0.857142857142857 26.3 26 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.71283289798329e-06 1.21777956272247e-05 0.546106015618645 0.855263157894737 26.3 26 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 8.020423449842e-06 3.21494720257047e-05 0.545984252850391 0.855072463768116 26.3 26 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000213634052767753 0.000683148892333735 0.545405879701185 0.854166666666667 26.3 26 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.93806677010404e-17 5.7455604455376e-16 0.544772423394912 0.853174603174603 26.3 26 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.93806677010404e-17 5.7455604455376e-16 0.544772423394912 0.853174603174603 26.3 26 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.93806677010404e-17 5.7455604455376e-16 0.544772423394912 0.853174603174603 26.3 26 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00198814824765988 0.0049202347068174 0.544623374852259 0.852941176470588 26.3 26 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0199156317543625 0.0364735443841156 0.542745363214838 0.85 26.3 26 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0199156317543625 0.0364735443841156 0.542745363214838 0.85 26.3 26 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00280810436626781 0.00651865010309804 0.541777902674348 0.848484848484849 26.3 26 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00280810436626781 0.00651865010309804 0.541777902674348 0.848484848484849 26.3 26 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.000423900372829696 0.00124888246487921 0.541357267656743 0.847826086956522 26.3 26 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000423900372829696 0.00124888246487921 0.541357267656743 0.847826086956522 26.3 26 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 5.11519557765499e-55 3.63946165350152e-52 0.541011814011064 0.847285067873303 26.3 26 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.59838012276234e-08 2.82047194598742e-07 0.540731999387332 0.846846846846847 26.3 26 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.00019772811453494 0.000633709700412656 0.540289501842825 0.846153846153846 26.3 26 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00877682807522999 0.0179962915721214 0.540289501842825 0.846153846153846 26.3 26 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00877682807522999 0.0179962915721214 0.540289501842825 0.846153846153846 26.3 26 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00877682807522999 0.0179962915721214 0.540289501842825 0.846153846153846 26.3 26 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0669486774883876 0.104920669676185 0.540289501842825 0.846153846153846 26.3 26 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0669486774883876 0.104920669676185 0.540289501842825 0.846153846153846 26.3 26 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0669486774883876 0.104920669676185 0.540289501842825 0.846153846153846 26.3 26 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0669486774883876 0.104920669676185 0.540289501842825 0.846153846153846 26.3 26 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.00128584705009786 0.0033947316369003 0.540289501842825 0.846153846153846 26.3 26 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00128584705009786 0.0033947316369003 0.540289501842825 0.846153846153846 26.3 26 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000594128181571335 0.00170038151691374 0.539198007899708 0.844444444444444 26.3 26 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.6193755110774e-94 5.15037135226313e-91 0.53917968714921 0.844415752098128 26.3 26 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 7.00147879355312e-35 9.05736756656918e-33 0.538999206901312 0.844133099824869 26.3 26 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0039484370134937 0.00904770671530038 0.538754588485317 0.84375 26.3 26 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0039484370134937 0.00904770671530038 0.538754588485317 0.84375 26.3 26 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.24162114737868e-07 7.06730757087944e-07 0.538015556127998 0.842592592592593 26.3 26 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00180106132711304 0.00448061235748576 0.537704384609127 0.842105263157895 26.3 26 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00180106132711304 0.00448061235748576 0.537704384609127 0.842105263157895 26.3 26 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0123383077450305 0.0240183473613932 0.536360123647604 0.84 26.3 26 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0123383077450305 0.0240183473613932 0.536360123647604 0.84 26.3 26 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0123383077450305 0.0240183473613932 0.536360123647604 0.84 26.3 26 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.61966593213859e-08 1.67918226190685e-07 0.535536221767961 0.838709677419355 26.3 26 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00552544542846682 0.012022490588239 0.535536221767961 0.838709677419355 26.3 26 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 4.89424285070062e-13 6.21831033620266e-12 0.53514388753956 0.838095238095238 26.3 26 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.000116840906298771 0.000387563192687998 0.533847898244103 0.836065573770492 26.3 26 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 6.87421977246292e-08 4.04215484967551e-07 0.532982806851712 0.834710743801653 26.3 26 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.57741476950345e-05 0.000129533364300341 0.532103297269449 0.833333333333333 26.3 26 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.00769328002679825 0.0158430354242169 0.532103297269449 0.833333333333333 26.3 26 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00769328002679825 0.0158430354242169 0.532103297269449 0.833333333333333 26.3 26 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0172413102317023 0.032756187529656 0.532103297269449 0.833333333333333 26.3 26 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0172413102317023 0.032756187529656 0.532103297269449 0.833333333333333 26.3 26 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0396071058366836 0.0669369496503572 0.532103297269449 0.833333333333333 26.3 26 3 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0396071058366836 0.0669369496503572 0.532103297269449 0.833333333333333 26.3 26 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0396071058366836 0.0669369496503572 0.532103297269449 0.833333333333333 26.3 26 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0949478514349641 0.138860012941371 0.532103297269449 0.833333333333333 26.3 26 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0949478514349641 0.138860012941371 0.532103297269449 0.833333333333333 26.3 26 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0949478514349641 0.138860012941371 0.532103297269449 0.833333333333333 26.3 26 3 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.0949478514349641 0.138860012941371 0.532103297269449 0.833333333333333 26.3 26 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0949478514349641 0.138860012941371 0.532103297269449 0.833333333333333 26.3 26 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0949478514349641 0.138860012941371 0.532103297269449 0.833333333333333 26.3 26 3 HYDROLYSIS OF LPC%REACTOME%REACT_199022.2 HYDROLYSIS OF LPC 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%REACT_226440.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_196559.2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 VITAMINS%REACTOME%REACT_213027.1 VITAMINS 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME DATABASE ID RELEASE 48%5605065 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.249628252901441 0.308351565866971 0.532103297269449 0.833333333333333 26.3 26 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.45743941641721e-27 4.83628225766405e-25 0.530805484349279 0.83130081300813 26.3 26 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0239374581769996 0.043172373873093 0.527476312075801 0.826086956521739 26.3 26 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 8.12884350101089e-51 2.3134688603877e-48 0.527309573870625 0.825825825825826 26.3 26 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.34249240648909e-05 5.1912138435706e-05 0.527153499155314 0.825581395348837 26.3 26 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 3.6698533898011e-23 2.0085389898796e-21 0.526853847699974 0.825112107623318 26.3 26 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.00303702170320546 0.0070385698430967 0.526782264296754 0.825 26.3 26 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00663456625310481 0.0142613108431543 0.525843258478043 0.823529411764706 26.3 26 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00663456625310481 0.0142613108431543 0.525843258478043 0.823529411764706 26.3 26 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0551997593700705 0.0873740351319359 0.525843258478043 0.823529411764706 26.3 26 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0551997593700705 0.0873740351319359 0.525843258478043 0.823529411764706 26.3 26 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 1.82886063953598e-05 6.99588357542931e-05 0.525843258478043 0.823529411764706 26.3 26 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 1.82886063953598e-05 6.99588357542931e-05 0.525843258478043 0.823529411764706 26.3 26 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00191962064195266 0.00476722543367999 0.525008586639189 0.822222222222222 26.3 26 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.13896078776919e-06 5.55048356505327e-06 0.524501821594171 0.821428571428571 26.3 26 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 7.66624714245959e-06 3.08165810274576e-05 0.524261774993899 0.821052631578947 26.3 26 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 7.66624714245959e-06 3.08165810274576e-05 0.524261774993899 0.821052631578947 26.3 26 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 7.66624714245959e-06 3.08165810274576e-05 0.524261774993899 0.821052631578947 26.3 26 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.44381252473224e-13 4.90013305841528e-12 0.523339242961481 0.819607843137255 26.3 26 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.0979728913675e-31 4.48570417262766e-29 0.523331454421772 0.819595645412131 26.3 26 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0330028544718617 0.0572720267237307 0.52242869186455 0.818181818181818 26.3 26 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.133182045961673 0.188357702531738 0.52242869186455 0.818181818181818 26.3 26 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00104825468415694 0.00278295973051365 0.52027877955235 0.814814814814815 26.3 26 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00355065746524798 0.00816249688699171 0.519728801984113 0.813953488372093 26.3 26 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0762427290243724 0.118962065133423 0.518800714837713 0.8125 26.3 26 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0762427290243724 0.118962065133423 0.518800714837713 0.8125 26.3 26 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 3.41988274304939e-05 0.000124145233248961 0.51791387600893 0.811111111111111 26.3 26 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 2.20128570699472e-05 8.2868506906177e-05 0.517540470186285 0.810526315789474 26.3 26 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0451581192481411 0.0761374451304559 0.516900345918893 0.80952380952381 26.3 26 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0272965223581927 0.0489205935966099 0.515730888122697 0.807692307692308 26.3 26 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0272965223581927 0.0489205935966099 0.515730888122697 0.807692307692308 26.3 26 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 6.12012891641316e-05 0.000213978954497689 0.515172737810875 0.806818181818182 26.3 26 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.17143087784296e-07 6.69456280791379e-07 0.514938674776886 0.806451612903226 26.3 26 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 6.54040685338765e-08 3.89414182107558e-07 0.513933916387077 0.804878048780488 26.3 26 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 8.15715036895185e-05 0.000279701806626951 0.513754907708433 0.804597701149425 26.3 26 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00214578701606329 0.00525551622006551 0.510819165378671 0.8 26.3 26 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0612836371676005 0.0964674952317428 0.510819165378671 0.8 26.3 26 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0612836371676005 0.0964674952317428 0.510819165378671 0.8 26.3 26 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0612836371676005 0.0964674952317428 0.510819165378671 0.8 26.3 26 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.184442395571869 0.243245161166607 0.510819165378671 0.8 26.3 26 3 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.184442395571869 0.243245161166607 0.510819165378671 0.8 26.3 26 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.184442395571869 0.243245161166607 0.510819165378671 0.8 26.3 26 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.184442395571869 0.243245161166607 0.510819165378671 0.8 26.3 26 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.184442395571869 0.243245161166607 0.510819165378671 0.8 26.3 26 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.000728640044413992 0.00199395150615598 0.508968371301212 0.797101449275362 26.3 26 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00451340847679605 0.0099884607503589 0.508212945147147 0.795918367346939 26.3 26 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 6.49224650822366e-13 8.10391822912479e-12 0.507293572979585 0.794478527607362 26.3 26 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.21783128865006e-06 1.0213507843848e-05 0.507196334418538 0.794326241134752 26.3 26 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0185120663786452 0.0350767915536779 0.507063142103828 0.794117647058823 26.3 26 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0185120663786452 0.0350767915536779 0.507063142103828 0.794117647058823 26.3 26 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0824241295854594 0.124704476238162 0.504097860571057 0.789473684210526 26.3 26 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0245390886291851 0.0441455412380916 0.503079481054752 0.787878787878788 26.3 26 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0245390886291851 0.0441455412380916 0.503079481054752 0.787878787878788 26.3 26 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.29957422620375e-05 5.03894856645214e-05 0.502045553759571 0.786259541984733 26.3 26 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.29957422620375e-05 5.03894856645214e-05 0.502045553759571 0.786259541984733 26.3 26 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00138291701336912 0.00362816054145466 0.501697394568337 0.785714285714286 26.3 26 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0125164060803129 0.024331756628805 0.501697394568337 0.785714285714286 26.3 26 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.140989487977175 0.189450464014656 0.501697394568337 0.785714285714286 26.3 26 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000254421478654339 0.000799209192329192 0.501206976782836 0.78494623655914 26.3 26 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000395528120234664 0.00117481728599377 0.500660829703527 0.784090909090909 26.3 26 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 5.184133158444e-10 4.26417426847734e-09 0.500215518443915 0.783393501805054 26.3 26 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0323215514239972 0.0562590478699274 0.498846841190108 0.78125 26.3 26 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.000192020222224356 0.000616805363939637 0.4973119278326 0.778846153846154 26.3 26 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00103200712972368 0.00274494606653607 0.496629744118152 0.777777777777778 26.3 26 3 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.251638356210808 0.309223990404128 0.496629744118152 0.777777777777778 26.3 26 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.251638356210808 0.309223990404128 0.496629744118152 0.777777777777778 26.3 26 3 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.251638356210808 0.309223990404128 0.496629744118152 0.777777777777778 26.3 26 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.251638356210808 0.309223990404128 0.496629744118152 0.777777777777778 26.3 26 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.251638356210808 0.309223990404128 0.496629744118152 0.777777777777778 26.3 26 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.251638356210808 0.309223990404128 0.496629744118152 0.777777777777778 26.3 26 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 6.32323884691308e-06 2.64646143504627e-05 0.49617785172132 0.777070063694268 26.3 26 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.042286010935065 0.0713795890398546 0.49434112778581 0.774193548387097 26.3 26 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.188278431256885 0.247204131714491 0.491172274402568 0.769230769230769 26.3 26 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.188278431256885 0.247204131714491 0.491172274402568 0.769230769230769 26.3 26 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 3.94678140794042e-06 1.71751374418936e-05 0.490110280295752 0.767567567567568 26.3 26 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0549287673828671 0.0871389475873132 0.489535033487893 0.766666666666667 26.3 26 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.144632380400853 0.194162148406051 0.488283025729612 0.764705882352941 26.3 26 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0355887817856532 0.0604329790942535 0.487294598552022 0.763157894736842 26.3 26 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.000271899943763452 0.000844789563265048 0.486743671928447 0.762295081967213 26.3 26 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0890595709731407 0.131056638567507 0.485278207109737 0.76 26.3 26 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 4.8047640995776e-07 2.50446128706921e-06 0.483274994696488 0.756862745098039 26.3 26 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0367214296310754 0.0622819956674854 0.482786406303012 0.75609756097561 26.3 26 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0130450405905814 0.0253248195912652 0.481509869004485 0.754098360655738 26.3 26 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00482224368857678 0.0105085034744943 0.480863720495354 0.753086419753086 26.3 26 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.188312915515466 0.247204131714491 0.478892967542504 0.75 26.3 26 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.188312915515466 0.247204131714491 0.478892967542504 0.75 26.3 26 3 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.337275492571204 0.406731377905783 0.478892967542504 0.75 26.3 26 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.337275492571204 0.406731377905783 0.478892967542504 0.75 26.3 26 3 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 48%5605104 DISSOLUTION OF FIBRIN CLOT 0.337275492571204 0.406731377905783 0.478892967542504 0.75 26.3 26 3 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.337275492571204 0.406731377905783 0.478892967542504 0.75 26.3 26 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.000109225698116096 0.000365713337456953 0.478892967542504 0.75 26.3 26 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00227602701334545 0.00553638707690696 0.478892967542504 0.75 26.3 26 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.2478846295418 0.308351565866971 0.478892967542504 0.75 26.3 26 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.2478846295418 0.308351565866971 0.478892967542504 0.75 26.3 26 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.2478846295418 0.308351565866971 0.478892967542504 0.75 26.3 26 3 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.2478846295418 0.308351565866971 0.478892967542504 0.75 26.3 26 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.2478846295418 0.308351565866971 0.478892967542504 0.75 26.3 26 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.2478846295418 0.308351565866971 0.478892967542504 0.75 26.3 26 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.00192509248930556 0.00477248538725055 0.477401089138945 0.747663551401869 26.3 26 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.00752698236917986 0.0155455673604397 0.476872322109835 0.746835443037975 26.3 26 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.145554611490844 0.195216034073016 0.471952489752033 0.739130434782609 26.3 26 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.186353814761028 0.245538405930503 0.470491336532986 0.736842105263158 26.3 26 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.114496341251217 0.166763862436522 0.468250901597115 0.733333333333333 26.3 26 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.241994821884757 0.303132598188388 0.468250901597115 0.733333333333333 26.3 26 3 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.241994821884757 0.303132598188388 0.468250901597115 0.733333333333333 26.3 26 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.241994821884757 0.303132598188388 0.468250901597115 0.733333333333333 26.3 26 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.026172114472835 0.0470238874934902 0.465210311327004 0.728571428571429 26.3 26 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0479772092547475 0.0798497880345096 0.464381059435155 0.727272727272727 26.3 26 3 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.321136661199055 0.38924826992015 0.464381059435155 0.727272727272727 26.3 26 3 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.321136661199055 0.38924826992015 0.464381059435155 0.727272727272727 26.3 26 3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.321136661199055 0.38924826992015 0.464381059435155 0.727272727272727 26.3 26 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000146762080178668 0.000477900320581796 0.463135402086885 0.725321888412017 26.3 26 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0477817489241714 0.0796175980317282 0.46237941693759 0.724137931034483 26.3 26 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0477817489241714 0.0796175980317282 0.46237941693759 0.724137931034483 26.3 26 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0477817489241714 0.0796175980317282 0.46237941693759 0.724137931034483 26.3 26 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.306500789456159 0.373097197088207 0.45608854051667 0.714285714285714 26.3 26 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.306500789456159 0.373097197088207 0.45608854051667 0.714285714285714 26.3 26 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.306500789456159 0.373097197088207 0.45608854051667 0.714285714285714 26.3 26 3 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.306500789456159 0.373097197088207 0.45608854051667 0.714285714285714 26.3 26 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.306500789456159 0.373097197088207 0.45608854051667 0.714285714285714 26.3 26 3 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.442514964893509 0.503759036034771 0.45608854051667 0.714285714285714 26.3 26 3 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.442514964893509 0.503759036034771 0.45608854051667 0.714285714285714 26.3 26 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0560331112890587 0.0885945748492561 0.454706454030256 0.712121212121212 26.3 26 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0020432912144962 0.00504792256636823 0.453773370260241 0.710659898477157 26.3 26 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.131797598605091 0.188357702531738 0.451638896218947 0.707317073170732 26.3 26 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.16691210413285 0.223439251346233 0.45072279298118 0.705882352941177 26.3 26 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.162550765622383 0.217805781055227 0.448692510129914 0.702702702702703 26.3 26 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.207509654873622 0.272153215562364 0.446966769706337 0.7 26.3 26 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.28087296657901 0.343960612256395 0.446966769706337 0.7 26.3 26 3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.408428931034999 0.466074072865119 0.446966769706337 0.7 26.3 26 3 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.408428931034999 0.466074072865119 0.446966769706337 0.7 26.3 26 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.381998575682861 0.436613633089728 0.442055046962311 0.692307692307692 26.3 26 3 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.381998575682861 0.436613633089728 0.442055046962311 0.692307692307692 26.3 26 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.283643414865295 0.347054668403538 0.432548486812584 0.67741935483871 26.3 26 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0473427180668587 0.0791641454866509 0.432292616663627 0.677018633540373 26.3 26 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.224963278032809 0.285742974883294 0.430026338201432 0.673469387755102 26.3 26 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0587847167654469 0.0928420110513106 0.429624143721259 0.672839506172839 26.3 26 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.072171672235885 0.112981616712502 0.426988412778183 0.668711656441718 26.3 26 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.259092463163899 0.317561218847741 0.425682637815559 0.666666666666667 26.3 26 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.259092463163899 0.317561218847741 0.425682637815559 0.666666666666667 26.3 26 3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.508549765291997 0.568026935644044 0.425682637815559 0.666666666666667 26.3 26 3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%REACT_210497.1 CREATION OF C4 AND C2 ACTIVATORS 0.508549765291997 0.568026935644044 0.425682637815559 0.666666666666667 26.3 26 3 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198585.2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS 0.508549765291997 0.568026935644044 0.425682637815559 0.666666666666667 26.3 26 3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.508549765291997 0.568026935644044 0.425682637815559 0.666666666666667 26.3 26 3 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.508549765291997 0.568026935644044 0.425682637815559 0.666666666666667 26.3 26 3 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.508549765291997 0.568026935644044 0.425682637815559 0.666666666666667 26.3 26 3 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%REACT_209334.1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION 0.508549765291997 0.568026935644044 0.425682637815559 0.666666666666667 26.3 26 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.0351653553486712 0.0597853054494136 0.424162342680503 0.664285714285714 26.3 26 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.111330694451855 0.162319239964128 0.421666763873903 0.660377358490566 26.3 26 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.111330694451855 0.162319239964128 0.421666763873903 0.660377358490566 26.3 26 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.126819486010672 0.181919484468938 0.420189958617939 0.658064516129032 26.3 26 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.336673050679626 0.406731377905783 0.416428667428264 0.652173913043478 26.3 26 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.0750834696906423 0.1174107443624 0.41306575550917 0.646907216494845 26.3 26 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.379735945023143 0.434725864656422 0.41149321655504 0.644444444444444 26.3 26 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.241601606700758 0.303132598188388 0.410479686465003 0.642857142857143 26.3 26 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.376227408258776 0.431056040219193 0.409619142048934 0.641509433962264 26.3 26 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.255332653563883 0.3134929818994 0.409194930012844 0.640845070422535 26.3 26 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.561190403247901 0.623885893610752 0.406333427005761 0.636363636363636 26.3 26 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.561190403247901 0.623885893610752 0.406333427005761 0.636363636363636 26.3 26 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.561190403247901 0.623885893610752 0.406333427005761 0.636363636363636 26.3 26 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.561190403247901 0.623885893610752 0.406333427005761 0.636363636363636 26.3 26 3 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.561190403247901 0.623885893610752 0.406333427005761 0.636363636363636 26.3 26 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.307842173621203 0.374090019695108 0.405486016313361 0.635036496350365 26.3 26 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.307842173621203 0.374090019695108 0.405486016313361 0.635036496350365 26.3 26 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.435027018469996 0.496028403271478 0.403964135886194 0.63265306122449 26.3 26 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.331869510643643 0.401915160549706 0.403772502045641 0.632352941176471 26.3 26 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.524923561341462 0.58585586493247 0.403278288456845 0.631578947368421 26.3 26 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.485912875186433 0.552721040280011 0.40135791565467 0.628571428571429 26.3 26 3 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.617914085430685 0.666635135381248 0.399077472952087 0.625 26.3 26 3 SPERM MOTILITY AND TAXES%REACTOME%REACT_196630.2 SPERM MOTILITY AND TAXES 0.617914085430685 0.666635135381248 0.399077472952087 0.625 26.3 26 3 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.617914085430685 0.666635135381248 0.399077472952087 0.625 26.3 26 3 RELAXIN RECEPTORS%REACTOME%REACT_198713.2 RELAXIN RECEPTORS 0.617914085430685 0.666635135381248 0.399077472952087 0.625 26.3 26 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.599000811282423 0.66042932916925 0.390209084664262 0.611111111111111 26.3 26 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.608341865827476 0.66042932916925 0.385468379404412 0.603686635944701 26.3 26 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.61851753749392 0.666780648374127 0.384565564844738 0.602272727272727 26.3 26 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.626904113709689 0.675310033163428 0.383114374034003 0.6 26.3 26 3 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.658731016677494 0.704356827169664 0.383114374034003 0.6 26.3 26 3 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.658731016677494 0.704356827169664 0.383114374034003 0.6 26.3 26 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.941671780351247 0.965417106224658 0.379376672823915 0.594146341463415 26.3 26 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.728707027172589 0.767542634838337 0.377621694836383 0.591397849462366 26.3 26 3 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.661876173472386 0.704356827169664 0.377309610791064 0.590909090909091 26.3 26 3 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.661876173472386 0.704356827169664 0.377309610791064 0.590909090909091 26.3 26 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.728142696370203 0.767516338470222 0.374084742322764 0.585858585858586 26.3 26 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.702610430544829 0.742252889877722 0.370755845839358 0.580645161290323 26.3 26 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.702610430544829 0.742252889877722 0.370755845839358 0.580645161290323 26.3 26 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.723562906035587 0.76382048611917 0.367635005386165 0.575757575757576 26.3 26 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.73357789770721 0.770961114060089 0.364870832413336 0.571428571428571 26.3 26 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.725284880511034 0.765070707907488 0.364870832413336 0.571428571428571 26.3 26 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.824985720372589 0.863837145025897 0.359731806604698 0.563380281690141 26.3 26 3 INTERACTION WITH THE ZONA PELLUCIDA%REACTOME%REACT_199072.2 INTERACTION WITH THE ZONA PELLUCIDA 0.754619485604047 0.79248968857163 0.354735531512966 0.555555555555556 26.3 26 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.784026101220336 0.822764854009246 0.354735531512966 0.555555555555556 26.3 26 3 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.784649203704695 0.822811950531895 0.351188176197836 0.55 26.3 26 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.869019591960341 0.898050021321398 0.345867143225142 0.541666666666667 26.3 26 3 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.810536393149252 0.849332317710887 0.340546110252447 0.533333333333333 26.3 26 3 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.860673000125876 0.890070987775524 0.333142933942611 0.521739130434783 26.3 26 3 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.8505079545306 0.880198414034214 0.319261978361669 0.5 26.3 26 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.977796578432919 0.997422602946268 0.314028175437707 0.491803278688525 26.3 26 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.992770448755454 1 0.307138105765656 0.481012658227848 26.3 26 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.998680275326631 1 0.301525201786021 0.472222222222222 26.3 26 3 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.918470332090438 0.946403535528381 0.297977846470891 0.466666666666667 26.3 26 3 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_220332.1 ANDROGEN BIOSYNTHESIS 0.918470332090438 0.946403535528381 0.297977846470891 0.466666666666667 26.3 26 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.962652869541645 0.984091259596093 0.297977846470891 0.466666666666667 26.3 26 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.998964701824942 1 0.290883135840632 0.455555555555556 26.3 26 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.975770721337213 0.996070112240211 0.288365657875056 0.451612903225806 26.3 26 3 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.950622109747013 0.973486981400574 0.273653124310002 0.428571428571429 26.3 26 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.983771126499992 1 0.273653124310002 0.428571428571429 26.3 26 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.996637937904377 1 0.271712322009931 0.425531914893617 26.3 26 3 MINERALOCORTICOID BIOSYNTHESIS%REACTOME%REACT_204887.1 MINERALOCORTICOID BIOSYNTHESIS 0.95091138731328 0.973486981400574 0.266051648634724 0.416666666666667 26.3 26 3 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.990262700634412 1 0.249857200456959 0.391304347826087 26.3 26 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.246081021104964 0.385390428211587 26.3 26 3 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%REACT_207160.1 GLUCOCORTICOID BIOSYNTHESIS 0.973196011460714 0.99415500668241 0.245586137201284 0.384615384615385 26.3 26 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.221116343060614 0.34629294755877 26.3 26 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999971909769808 1 0.21284131890778 0.333333333333333 26.3 26 3 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.999693501003274 1 0.205975469910754 0.32258064516129 26.3 26 3 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.999164567815881 1 0.204327666151468 0.32 26.3 26 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.999938736832831 1 0.201639144228423 0.315789473684211 26.3 26 3 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999996434491141 1 0.190198625406952 0.297872340425532 26.3 26 3 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.999999968407962 1 0.136826562155001 0.214285714285714 26.3 26 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0350158298848282 0.0548387096774194 26.3 26 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.000260529001107534 0.000787118404620001 1.80502728625765 1 27.1 27 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 5.33060930047756e-07 2.98640040731479e-06 1.80502728625765 1 27.1 27 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 1.17874692224008e-05 5.01599016723155e-05 1.80502728625765 1 27.1 27 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 1.17874692224008e-05 5.01599016723155e-05 1.80502728625765 1 27.1 27 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 3.30817801397303e-05 0.000127575536961616 1.80502728625765 1 27.1 27 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 3.30817801397303e-05 0.000127575536961616 1.80502728625765 1 27.1 27 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 3.30817801397303e-05 0.000127575536961616 1.80502728625765 1 27.1 27 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 3.30817801397303e-05 0.000127575536961616 1.80502728625765 1 27.1 27 1 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.000731063301941278 0.00202000597798532 1.80502728625765 1 27.1 27 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00575550493301973 0.0131885402893512 1.80502728625765 1 27.1 27 1 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.00575550493301973 0.0131885402893512 1.80502728625765 1 27.1 27 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00575550493301973 0.0131885402893512 1.80502728625765 1 27.1 27 1 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00575550493301973 0.0131885402893512 1.80502728625765 1 27.1 27 1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.00575550493301973 0.0131885402893512 1.80502728625765 1 27.1 27 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00575550493301973 0.0131885402893512 1.80502728625765 1 27.1 27 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00205130750126111 0.00508538427577449 1.80502728625765 1 27.1 27 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00205130750126111 0.00508538427577449 1.80502728625765 1 27.1 27 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00205130750126111 0.00508538427577449 1.80502728625765 1 27.1 27 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 1.08041151751461e-07 6.61246602678957e-07 1.71002585013882 0.947368421052632 27.1 27 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 2.02367091833027e-06 1.02116443857588e-05 1.69221308086655 0.9375 27.1 27 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 5.33736884633189e-06 2.49838021984549e-05 1.68469213384047 0.933333333333333 27.1 27 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 5.33736884633189e-06 2.49838021984549e-05 1.68469213384047 0.933333333333333 27.1 27 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 1.40182096297576e-05 5.81571787263704e-05 1.67609676581067 0.928571428571429 27.1 27 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 1.40182096297576e-05 5.81571787263704e-05 1.67609676581067 0.928571428571429 27.1 27 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 1.40182096297576e-05 5.81571787263704e-05 1.67609676581067 0.928571428571429 27.1 27 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 1.40182096297576e-05 5.81571787263704e-05 1.67609676581067 0.928571428571429 27.1 27 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 1.40182096297576e-05 5.81571787263704e-05 1.67609676581067 0.928571428571429 27.1 27 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 3.66420363528497e-05 0.000140165639059422 1.6661790334686 0.923076923076923 27.1 27 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 3.66420363528497e-05 0.000140165639059422 1.6661790334686 0.923076923076923 27.1 27 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 1.65751598494491e-08 1.25459853541309e-07 1.65460834573618 0.916666666666667 27.1 27 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 9.52517744851355e-05 0.00031967753559516 1.65460834573618 0.916666666666667 27.1 27 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 9.52517744851355e-05 0.00031967753559516 1.65460834573618 0.916666666666667 27.1 27 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 9.52517744851355e-05 0.00031967753559516 1.65460834573618 0.916666666666667 27.1 27 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 9.52517744851355e-05 0.00031967753559516 1.65460834573618 0.916666666666667 27.1 27 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 9.52517744851355e-05 0.00031967753559516 1.65460834573618 0.916666666666667 27.1 27 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 9.52517744851355e-05 0.00031967753559516 1.65460834573618 0.916666666666667 27.1 27 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 9.52517744851355e-05 0.00031967753559516 1.65460834573618 0.916666666666667 27.1 27 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000246024889313026 0.000757777959940338 1.64093389659786 0.909090909090909 27.1 27 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.000246024889313026 0.000757777959940338 1.64093389659786 0.909090909090909 27.1 27 1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.000630661639842101 0.00174937916860684 1.62452455763188 0.9 27.1 27 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000630661639842101 0.00174937916860684 1.62452455763188 0.9 27.1 27 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.000630661639842101 0.00174937916860684 1.62452455763188 0.9 27.1 27 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 1.4617272131433e-08 1.1182999055392e-07 1.60446869889569 0.888888888888889 27.1 27 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00160204288108807 0.00409283127430578 1.60446869889569 0.888888888888889 27.1 27 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 3.65903777484114e-08 2.37753915689449e-07 1.59675490707407 0.884615384615385 27.1 27 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 1.14679250106411e-05 4.9451082697401e-05 1.59267113493322 0.882352941176471 27.1 27 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 1.14679250106411e-05 4.9451082697401e-05 1.59267113493322 0.882352941176471 27.1 27 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 1.14679250106411e-05 4.9451082697401e-05 1.59267113493322 0.882352941176471 27.1 27 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 7.59501524170229e-10 7.20513779262824e-09 1.5862361000446 0.878787878787879 27.1 27 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 2.85332543423433e-05 0.000111546211343831 1.57939887547544 0.875 27.1 27 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 2.85332543423433e-05 0.000111546211343831 1.57939887547544 0.875 27.1 27 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 2.85332543423433e-05 0.000111546211343831 1.57939887547544 0.875 27.1 27 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.00402480340777749 0.00943541227226914 1.57939887547544 0.875 27.1 27 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.57358111252287e-07 3.08607234362648e-06 1.56958894457187 0.869565217391304 27.1 27 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 7.04436747220251e-05 0.000252497101081717 1.5643569814233 0.866666666666667 27.1 27 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 2.37595591730441e-10 2.46787246009063e-09 1.56110468000661 0.864864864864865 27.1 27 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 6.74346944945388e-08 4.26486978958794e-07 1.5471662453637 0.857142857142857 27.1 27 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.000172384996691402 0.000545119667315255 1.5471662453637 0.857142857142857 27.1 27 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000172384996691402 0.000545119667315255 1.5471662453637 0.857142857142857 27.1 27 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000172384996691402 0.000545119667315255 1.5471662453637 0.857142857142857 27.1 27 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.000172384996691402 0.000545119667315255 1.5471662453637 0.857142857142857 27.1 27 1 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00997277269718008 0.0216330115062306 1.5471662453637 0.857142857142857 27.1 27 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 2.97469770068795e-11 4.10970371658151e-10 1.5471662453637 0.857142857142857 27.1 27 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 8.04632835251645e-06 3.61196379988357e-05 1.534273193319 0.85 27.1 27 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 8.04632835251645e-06 3.61196379988357e-05 1.534273193319 0.85 27.1 27 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 8.04632835251645e-06 3.61196379988357e-05 1.534273193319 0.85 27.1 27 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 8.04632835251645e-06 3.61196379988357e-05 1.534273193319 0.85 27.1 27 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 8.04632835251645e-06 3.61196379988357e-05 1.534273193319 0.85 27.1 27 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000417605334212707 0.00121773030857517 1.52733078067955 0.846153846153846 27.1 27 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000417605334212707 0.00121773030857517 1.52733078067955 0.846153846153846 27.1 27 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000417605334212707 0.00121773030857517 1.52733078067955 0.846153846153846 27.1 27 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.000417605334212707 0.00121773030857517 1.52733078067955 0.846153846153846 27.1 27 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.12123857124177e-11 3.01852248687704e-10 1.5242452639509 0.844444444444444 27.1 27 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 1.9305838487448e-05 7.87169288471018e-05 1.52002297790118 0.842105263157895 27.1 27 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 1.9305838487448e-05 7.87169288471018e-05 1.52002297790118 0.842105263157895 27.1 27 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 1.9305838487448e-05 7.87169288471018e-05 1.52002297790118 0.842105263157895 27.1 27 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 5.04751501688865e-11 6.65056839725236e-10 1.51786385435302 0.840909090909091 27.1 27 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 9.34069545534375e-07 4.99692091464442e-06 1.51622292045642 0.84 27.1 27 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.07115033374362e-16 4.61893007550659e-15 1.50418940521471 0.833333333333333 27.1 27 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 5.53159809724772e-09 4.54997924415231e-08 1.50418940521471 0.833333333333333 27.1 27 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 5.53159809724772e-09 4.54997924415231e-08 1.50418940521471 0.833333333333333 27.1 27 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 4.59203589383291e-05 0.000167981158789826 1.50418940521471 0.833333333333333 27.1 27 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 4.59203589383291e-05 0.000167981158789826 1.50418940521471 0.833333333333333 27.1 27 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 4.59203589383291e-05 0.000167981158789826 1.50418940521471 0.833333333333333 27.1 27 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 2.21397361848596e-06 1.11324539191008e-05 1.50418940521471 0.833333333333333 27.1 27 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000999890463452481 0.00268039104534734 1.50418940521471 0.833333333333333 27.1 27 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000999890463452481 0.00268039104534734 1.50418940521471 0.833333333333333 27.1 27 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000999890463452481 0.00268039104534734 1.50418940521471 0.833333333333333 27.1 27 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.000999890463452481 0.00268039104534734 1.50418940521471 0.833333333333333 27.1 27 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.000999890463452481 0.00268039104534734 1.50418940521471 0.833333333333333 27.1 27 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0242764920918129 0.0465572078795818 1.50418940521471 0.833333333333333 27.1 27 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 2.57889058985454e-07 1.51643029312521e-06 1.49381568517874 0.827586206896552 27.1 27 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 5.20836617011179e-06 2.46229403989006e-05 1.49110949734327 0.826086956521739 27.1 27 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 5.20836617011179e-06 2.46229403989006e-05 1.49110949734327 0.826086956521739 27.1 27 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000108171457890286 0.000356314779115457 1.486493059271 0.823529411764706 27.1 27 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000108171457890286 0.000356314779115457 1.486493059271 0.823529411764706 27.1 27 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000108171457890286 0.000356314779115457 1.486493059271 0.823529411764706 27.1 27 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.85815435780056e-10 1.98808545199263e-09 1.48413354647851 0.822222222222222 27.1 27 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 1.21525930806951e-05 5.14676784340151e-05 1.47684050693808 0.818181818181818 27.1 27 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00236152701722294 0.00578391212652021 1.47684050693808 0.818181818181818 27.1 27 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00236152701722294 0.00578391212652021 1.47684050693808 0.818181818181818 27.1 27 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00236152701722294 0.00578391212652021 1.47684050693808 0.818181818181818 27.1 27 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00236152701722294 0.00578391212652021 1.47684050693808 0.818181818181818 27.1 27 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 5.17046939172465e-11 6.75007150864604e-10 1.47349166225114 0.816326530612245 27.1 27 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.000252055496367313 0.000764765397293573 1.46658467008434 0.8125 27.1 27 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000252055496367313 0.000764765397293573 1.46658467008434 0.8125 27.1 27 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000252055496367313 0.000764765397293573 1.46658467008434 0.8125 27.1 27 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000252055496367313 0.000764765397293573 1.46658467008434 0.8125 27.1 27 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000252055496367313 0.000764765397293573 1.46658467008434 0.8125 27.1 27 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.000252055496367313 0.000764765397293573 1.46658467008434 0.8125 27.1 27 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000252055496367313 0.000764765397293573 1.46658467008434 0.8125 27.1 27 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 2.81018326307289e-05 0.000110772597876807 1.46121256506572 0.80952380952381 27.1 27 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 2.81018326307289e-05 0.000110772597876807 1.46121256506572 0.80952380952381 27.1 27 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.81018326307289e-05 0.000110772597876807 1.46121256506572 0.80952380952381 27.1 27 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.72650454064786e-10 2.8114608415521e-09 1.45938376335725 0.808510638297872 27.1 27 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 3.2134231808654e-06 1.56599355697653e-05 1.45790665428502 0.807692307692308 27.1 27 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 4.39267414358722e-08 2.82840511598399e-07 1.45404975837422 0.805555555555556 27.1 27 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 4.39267414358722e-08 2.82840511598399e-07 1.45404975837422 0.805555555555556 27.1 27 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 5.2091150918693e-09 4.33483671095322e-08 1.4528268401586 0.804878048780488 27.1 27 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 5.2091150918693e-09 4.33483671095322e-08 1.4528268401586 0.804878048780488 27.1 27 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 8.50618215918198e-07 4.58496106534695e-06 1.44402182900612 0.8 27.1 27 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000580150284568909 0.00161873304890501 1.44402182900612 0.8 27.1 27 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000580150284568909 0.00161873304890501 1.44402182900612 0.8 27.1 27 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000580150284568909 0.00161873304890501 1.44402182900612 0.8 27.1 27 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000580150284568909 0.00161873304890501 1.44402182900612 0.8 27.1 27 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000580150284568909 0.00161873304890501 1.44402182900612 0.8 27.1 27 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000580150284568909 0.00161873304890501 1.44402182900612 0.8 27.1 27 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.00548756784607193 0.0127386770717135 1.44402182900612 0.8 27.1 27 1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.00548756784607193 0.0127386770717135 1.44402182900612 0.8 27.1 27 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00548756784607193 0.0127386770717135 1.44402182900612 0.8 27.1 27 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 8.56507101943845e-10 8.01848425043481e-09 1.42897993495397 0.791666666666667 27.1 27 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000145724810629133 0.000469154763631802 1.42502154178235 0.789473684210526 27.1 27 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.91313412829546e-09 1.71219488337386e-08 1.42097892747943 0.787234042553192 27.1 27 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.59446470752131e-08 1.21332795657905e-07 1.41823572491672 0.785714285714286 27.1 27 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 4.30860173006397e-06 2.05054858256891e-05 1.41823572491672 0.785714285714286 27.1 27 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00131674657179082 0.0034570671063807 1.41823572491672 0.785714285714286 27.1 27 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00131674657179082 0.0034570671063807 1.41823572491672 0.785714285714286 27.1 27 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.66978176125312e-11 2.4001004507709e-10 1.41393804090182 0.783333333333333 27.1 27 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.66978176125312e-11 2.4001004507709e-10 1.41393804090182 0.783333333333333 27.1 27 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.66978176125312e-11 2.4001004507709e-10 1.41393804090182 0.783333333333333 27.1 27 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.66978176125312e-11 2.4001004507709e-10 1.41393804090182 0.783333333333333 27.1 27 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.66978176125312e-11 2.4001004507709e-10 1.41393804090182 0.783333333333333 27.1 27 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.66978176125312e-11 2.4001004507709e-10 1.41393804090182 0.783333333333333 27.1 27 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.66978176125312e-11 2.4001004507709e-10 1.41393804090182 0.783333333333333 27.1 27 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 3.71518099587948e-05 0.000141472212462433 1.41263005011468 0.782608695652174 27.1 27 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 3.53659738376527e-08 2.30852205371467e-07 1.40880178439621 0.780487804878049 27.1 27 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 3.53659738376527e-08 2.30852205371467e-07 1.40880178439621 0.780487804878049 27.1 27 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 9.57279158199328e-06 4.27024527309606e-05 1.40391011153373 0.777777777777778 27.1 27 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 9.57279158199328e-06 4.27024527309606e-05 1.40391011153373 0.777777777777778 27.1 27 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 2.95657008086849e-07 1.71024358742921e-06 1.40391011153373 0.777777777777778 27.1 27 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000326050304222138 0.000962592495659963 1.40391011153373 0.777777777777778 27.1 27 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.000326050304222138 0.000962592495659963 1.40391011153373 0.777777777777778 27.1 27 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000326050304222138 0.000962592495659963 1.40391011153373 0.777777777777778 27.1 27 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0125044652511905 0.0262446224962302 1.40391011153373 0.777777777777778 27.1 27 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0125044652511905 0.0262446224962302 1.40391011153373 0.777777777777778 27.1 27 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0125044652511905 0.0262446224962302 1.40391011153373 0.777777777777778 27.1 27 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0125044652511905 0.0262446224962302 1.40391011153373 0.777777777777778 27.1 27 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0125044652511905 0.0262446224962302 1.40391011153373 0.777777777777778 27.1 27 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0125044652511905 0.0262446224962302 1.40391011153373 0.777777777777778 27.1 27 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0125044652511905 0.0262446224962302 1.40391011153373 0.777777777777778 27.1 27 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.6631405281194e-12 5.41378424501987e-11 1.40091669978206 0.776119402985075 27.1 27 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.6631405281194e-12 5.41378424501987e-11 1.40091669978206 0.776119402985075 27.1 27 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 8.23292471008439e-05 0.000289986432238864 1.39479381210818 0.772727272727273 27.1 27 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 8.23292471008439e-05 0.000289986432238864 1.39479381210818 0.772727272727273 27.1 27 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 2.10674790083817e-05 8.56543503683632e-05 1.3884825278905 0.769230769230769 27.1 27 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00294084089425172 0.00717807305749606 1.3884825278905 0.769230769230769 27.1 27 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00294084089425172 0.00717807305749606 1.3884825278905 0.769230769230769 27.1 27 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.4167423072509e-06 7.25188598279869e-06 1.38031498360879 0.764705882352941 27.1 27 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000719678621417647 0.00199241766201812 1.38031498360879 0.764705882352941 27.1 27 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 3.70843357802075e-07 2.12786329900142e-06 1.37752082372294 0.763157894736842 27.1 27 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.2345044143228e-10 2.3380145452804e-09 1.37671572680668 0.76271186440678 27.1 27 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.2345044143228e-10 2.3380145452804e-09 1.37671572680668 0.76271186440678 27.1 27 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000180318427495799 0.000565183088824937 1.37525888476773 0.761904761904762 27.1 27 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000180318427495799 0.000565183088824937 1.37525888476773 0.761904761904762 27.1 27 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000180318427495799 0.000565183088824937 1.37525888476773 0.761904761904762 27.1 27 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.5928726933028e-11 2.4001004507709e-10 1.37397599401702 0.761194029850746 27.1 27 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.14120344038836e-12 2.5776706280518e-11 1.37182073755581 0.76 27.1 27 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.14120344038836e-12 2.5776706280518e-11 1.37182073755581 0.76 27.1 27 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.14120344038836e-12 2.5776706280518e-11 1.37182073755581 0.76 27.1 27 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.14120344038836e-12 2.5776706280518e-11 1.37182073755581 0.76 27.1 27 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.14120344038836e-12 2.5776706280518e-11 1.37182073755581 0.76 27.1 27 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.14120344038836e-12 2.5776706280518e-11 1.37182073755581 0.76 27.1 27 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.81051697293886e-10 4.69653872922955e-09 1.36933104474718 0.758620689655172 27.1 27 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.81051697293886e-10 4.69653872922955e-09 1.36933104474718 0.758620689655172 27.1 27 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.18085502882823e-05 5.01599016723155e-05 1.36933104474718 0.758620689655172 27.1 27 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 7.99969319911461e-07 4.32835111115593e-06 1.36596659500579 0.756756756756757 27.1 27 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 4.71684665377843e-14 1.39834849756806e-12 1.36426480938078 0.755813953488372 27.1 27 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 6.5672761997289e-06 3.01804982437876e-05 1.35377046469324 0.75 27.1 27 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0015644346491737 0.00406981810927638 1.35377046469324 0.75 27.1 27 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0015644346491737 0.00406981810927638 1.35377046469324 0.75 27.1 27 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0278166805653879 0.0521516949203518 1.35377046469324 0.75 27.1 27 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 2.53653611377811e-05 0.000101390193536692 1.35377046469324 0.75 27.1 27 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 2.53653611377811e-05 0.000101390193536692 1.35377046469324 0.75 27.1 27 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 9.88460662363096e-05 0.000328640075360441 1.35377046469324 0.75 27.1 27 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 9.88460662363096e-05 0.000328640075360441 1.35377046469324 0.75 27.1 27 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 9.88460662363096e-05 0.000328640075360441 1.35377046469324 0.75 27.1 27 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 9.88460662363096e-05 0.000328640075360441 1.35377046469324 0.75 27.1 27 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00038986760543501 0.00114624298044219 1.35377046469324 0.75 27.1 27 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00038986760543501 0.00114624298044219 1.35377046469324 0.75 27.1 27 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00644643667853431 0.0146538009481699 1.35377046469324 0.75 27.1 27 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00644643667853431 0.0146538009481699 1.35377046469324 0.75 27.1 27 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00644643667853431 0.0146538009481699 1.35377046469324 0.75 27.1 27 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 5.1970005109787e-33 9.24416465890337e-31 1.35174689150236 0.748878923766816 27.1 27 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.29648413504874e-10 3.35064066012454e-09 1.34660765800174 0.746031746031746 27.1 27 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.75057002600302e-08 1.31802177090069e-07 1.34492229172138 0.745098039215686 27.1 27 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 3.63257117367355e-06 1.74633404734374e-05 1.34087741264854 0.742857142857143 27.1 27 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 3.63257117367355e-06 1.74633404734374e-05 1.34087741264854 0.742857142857143 27.1 27 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 6.94395961761892e-10 6.72194186113722e-09 1.33921379302987 0.741935483870968 27.1 27 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 5.39094430837773e-05 0.000194703394690901 1.33705724907974 0.740740740740741 27.1 27 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 5.39094430837773e-05 0.000194703394690901 1.33705724907974 0.740740740740741 27.1 27 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 5.39094430837773e-05 0.000194703394690901 1.33705724907974 0.740740740740741 27.1 27 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 5.39094430837773e-05 0.000194703394690901 1.33705724907974 0.740740740740741 27.1 27 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 5.39094430837773e-05 0.000194703394690901 1.33705724907974 0.740740740740741 27.1 27 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000210331985669983 0.000657264203847835 1.33415060288609 0.739130434782609 27.1 27 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.03979202440126e-10 1.13817234671e-09 1.33415060288609 0.739130434782609 27.1 27 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 7.19547111886107e-19 4.09566216085572e-17 1.33294322677488 0.738461538461539 27.1 27 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.000830961686282547 0.00227180338598374 1.33002010566353 0.736842105263158 27.1 27 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000830961686282547 0.00227180338598374 1.33002010566353 0.736842105263158 27.1 27 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 7.63883529615337e-06 3.48399443154687e-05 1.32722594577768 0.735294117647059 27.1 27 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.34425565676591e-12 4.97891910384761e-11 1.32658631881586 0.734939759036145 27.1 27 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 8.7194241977375e-12 1.49490851004584e-10 1.32520990636637 0.734177215189873 27.1 27 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.04481048212606e-15 3.91254030543523e-14 1.32479066881295 0.73394495412844 27.1 27 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00334238636165108 0.00807506925743546 1.32368667658894 0.733333333333333 27.1 27 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00334238636165108 0.00807506925743546 1.32368667658894 0.733333333333333 27.1 27 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.09972089171532e-06 5.69055574149418e-06 1.32075167287145 0.731707317073171 27.1 27 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.09972089171532e-06 5.69055574149418e-06 1.32075167287145 0.731707317073171 27.1 27 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.09972089171532e-06 5.69055574149418e-06 1.32075167287145 0.731707317073171 27.1 27 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.09972089171532e-06 5.69055574149418e-06 1.32075167287145 0.731707317073171 27.1 27 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.45948946214728e-22 3.73285500272681e-20 1.31992620307591 0.73125 27.1 27 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 8.84292281889497e-17 3.93233724102735e-15 1.3196417975161 0.73109243697479 27.1 27 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000113264323582109 0.000369667734993903 1.31905840149597 0.730769230769231 27.1 27 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000113264323582109 0.000369667734993903 1.31905840149597 0.730769230769231 27.1 27 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000113264323582109 0.000369667734993903 1.31905840149597 0.730769230769231 27.1 27 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000113264323582109 0.000369667734993903 1.31905840149597 0.730769230769231 27.1 27 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.7083584716218e-12 5.42816071143354e-11 1.31660813821146 0.729411764705882 27.1 27 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.94005006333581e-28 4.67224270010571e-26 1.31509130855914 0.728571428571429 27.1 27 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.0048062101852e-11 1.64349337596958e-10 1.31477296159508 0.728395061728395 27.1 27 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.0048062101852e-11 1.64349337596958e-10 1.31477296159508 0.728395061728395 27.1 27 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.59099676071115e-05 6.56228518983178e-05 1.31274711727829 0.727272727272727 27.1 27 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 6.02975471638215e-07 3.3257135509348e-06 1.31274711727829 0.727272727272727 27.1 27 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000441622908549011 0.00128513169502095 1.31274711727829 0.727272727272727 27.1 27 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0138236767230026 0.0283445129349174 1.31274711727829 0.727272727272727 27.1 27 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.38475597960797e-10 1.50420439616957e-09 1.31049926262542 0.726027397260274 27.1 27 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 2.27714450679188e-06 1.13697425725082e-05 1.3086447825368 0.725 27.1 27 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 2.27714450679188e-06 1.13697425725082e-05 1.3086447825368 0.725 27.1 27 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.30095277283177e-07 1.90172299422656e-06 1.30576441984596 0.723404255319149 27.1 27 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.91222594135342e-09 1.71219488337386e-08 1.30517357621707 0.723076923076923 27.1 27 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00174311224612598 0.00442937272542369 1.30363081785275 0.722222222222222 27.1 27 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.23098081163366e-11 5.73398637614733e-10 1.30236145970489 0.721518987341772 27.1 27 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.23098081163366e-11 5.73398637614733e-10 1.30236145970489 0.721518987341772 27.1 27 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.24079326150982e-06 6.39727830119011e-06 1.30129874125551 0.720930232558139 27.1 27 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.42027403627964e-13 3.81330179929421e-12 1.29961964610551 0.72 27.1 27 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.80495619129868e-07 1.07466638502846e-06 1.29961964610551 0.72 27.1 27 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.28702286635742e-11 2.0577904930636e-10 1.29537252307902 0.717647058823529 27.1 27 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 6.75549348408259e-07 3.68316752024886e-06 1.29491087927179 0.717391304347826 27.1 27 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 6.75549348408259e-07 3.68316752024886e-06 1.29491087927179 0.717391304347826 27.1 27 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 6.75549348408259e-07 3.68316752024886e-06 1.29491087927179 0.717391304347826 27.1 27 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.44988758867084e-08 1.11523785874519e-07 1.29360288848465 0.716666666666667 27.1 27 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 2.14382075698812e-09 1.86015666902079e-08 1.2931538767219 0.716417910447761 27.1 27 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.14382075698812e-09 1.86015666902079e-08 1.2931538767219 0.716417910447761 27.1 27 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 5.84725060882484e-13 1.45976098532592e-11 1.28930520446975 0.714285714285714 27.1 27 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.17553403539501e-09 1.07921608539813e-08 1.28930520446975 0.714285714285714 27.1 27 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.93501221550336e-09 6.34355190037151e-08 1.28930520446975 0.714285714285714 27.1 27 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 7.93501221550336e-09 6.34355190037151e-08 1.28930520446975 0.714285714285714 27.1 27 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000125269647948768 0.000407914665975051 1.28930520446975 0.714285714285714 27.1 27 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00091374055028304 0.00248614302686953 1.28930520446975 0.714285714285714 27.1 27 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00700107670040399 0.015763500228916 1.28930520446975 0.714285714285714 27.1 27 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00700107670040399 0.015763500228916 1.28930520446975 0.714285714285714 27.1 27 1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0600357905783948 0.0996860326640091 1.28930520446975 0.714285714285714 27.1 27 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 9.59491335222054e-11 1.13817234671e-09 1.28608194145857 0.7125 27.1 27 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 7.87019771911993e-12 1.3657672383302e-10 1.28357495911655 0.711111111111111 27.1 27 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 4.31933821152245e-12 8.30597064188709e-11 1.2809871063764 0.709677419354839 27.1 27 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 6.68789191434807e-05 0.000240325004901952 1.2809871063764 0.709677419354839 27.1 27 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 4.3430434391948e-21 2.94292895903533e-19 1.28031005188043 0.709302325581395 27.1 27 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.08736264952126e-07 6.61246602678957e-07 1.27992843934633 0.709090909090909 27.1 27 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.08736264952126e-07 6.61246602678957e-07 1.27992843934633 0.709090909090909 27.1 27 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.08736264952126e-07 6.61246602678957e-07 1.27992843934633 0.709090909090909 27.1 27 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.08736264952126e-07 6.61246602678957e-07 1.27992843934633 0.709090909090909 27.1 27 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.29648778821512e-09 1.17509689339498e-08 1.2785609944325 0.708333333333333 27.1 27 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.29648778821512e-09 1.17509689339498e-08 1.2785609944325 0.708333333333333 27.1 27 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00048108350429462 0.00139710576859437 1.2785609944325 0.708333333333333 27.1 27 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 5.77995097862208e-11 7.34363414516002e-10 1.27413690794658 0.705882352941177 27.1 27 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 5.77995097862208e-11 7.34363414516002e-10 1.27413690794658 0.705882352941177 27.1 27 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 5.77995097862208e-11 7.34363414516002e-10 1.27413690794658 0.705882352941177 27.1 27 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00359184911578822 0.00860471597940511 1.27413690794658 0.705882352941177 27.1 27 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00359184911578822 0.00860471597940511 1.27413690794658 0.705882352941177 27.1 27 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00359184911578822 0.00860471597940511 1.27413690794658 0.705882352941177 27.1 27 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00359184911578822 0.00860471597940511 1.27413690794658 0.705882352941177 27.1 27 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.02521411501781e-07 2.29115187426814e-06 1.27413690794658 0.705882352941177 27.1 27 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.02521411501781e-07 2.29115187426814e-06 1.27413690794658 0.705882352941177 27.1 27 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.32688107797915e-16 2.89615327054565e-14 1.27331382208873 0.705426356589147 27.1 27 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.74015200316775e-12 8.87531092172068e-11 1.27301924399224 0.705263157894737 27.1 27 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.74015200316775e-12 8.87531092172068e-11 1.27301924399224 0.705263157894737 27.1 27 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 4.8556266549147e-15 1.77168121280606e-13 1.27239628375539 0.704918032786885 27.1 27 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.21443448667053e-08 2.11765753450563e-07 1.27239628375539 0.704918032786885 27.1 27 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.21443448667053e-08 2.11765753450563e-07 1.27239628375539 0.704918032786885 27.1 27 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.21443448667053e-08 2.11765753450563e-07 1.27239628375539 0.704918032786885 27.1 27 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.76174337581902e-06 1.3645697304828e-05 1.27172376986334 0.704545454545455 27.1 27 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.76174337581902e-06 1.3645697304828e-05 1.27172376986334 0.704545454545455 27.1 27 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.5952063884816e-09 2.2381689035208e-08 1.27114597623778 0.704225352112676 27.1 27 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.76634621498909e-26 3.57300710928632e-24 1.27080396386749 0.704035874439462 27.1 27 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.13694399044624e-13 5.63124314519444e-12 1.27020438662575 0.703703703703704 27.1 27 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.18108256941014e-07 1.29320020677943e-06 1.27020438662575 0.703703703703704 27.1 27 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 5.29449513222462e-15 1.79382537456087e-13 1.26643043471303 0.701612903225806 27.1 27 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 5.29449513222462e-15 1.79382537456087e-13 1.26643043471303 0.701612903225806 27.1 27 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 5.29449513222462e-15 1.79382537456087e-13 1.26643043471303 0.701612903225806 27.1 27 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.00582156356131e-30 9.4272258978104e-28 1.26559384438755 0.701149425287356 27.1 27 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 6.40795398046154e-08 4.07076719383785e-07 1.26351910038035 0.7 27.1 27 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.000134776614009988 0.000436872714661077 1.26351910038035 0.7 27.1 27 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.3223048242097e-13 5.90114243723287e-12 1.26351910038035 0.7 27.1 27 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.81876398185263e-12 5.57097381413374e-11 1.26351910038035 0.7 27.1 27 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00186018120826014 0.00468502275991891 1.26351910038035 0.7 27.1 27 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00186018120826014 0.00468502275991891 1.26351910038035 0.7 27.1 27 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00186018120826014 0.00468502275991891 1.26351910038035 0.7 27.1 27 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00186018120826014 0.00468502275991891 1.26351910038035 0.7 27.1 27 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0288772258631338 0.0528178565594336 1.26351910038035 0.7 27.1 27 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.28225788595771e-33 8.70521853102545e-31 1.26290305011201 0.699658703071672 27.1 27 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.41554109980413e-21 2.43015749251064e-19 1.26253274667202 0.699453551912568 27.1 27 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.80869495088564e-09 2.40769452717486e-08 1.26104646026219 0.698630136986301 27.1 27 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 4.34316324191354e-07 2.46227939969839e-06 1.26011338851949 0.69811320754717 27.1 27 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 5.51228785889957e-06 2.57179856498823e-05 1.25932136250534 0.697674418604651 27.1 27 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 7.1643599316302e-05 0.000255510881772175 1.25804932072503 0.696969696969697 27.1 27 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 7.1643599316302e-05 0.000255510881772175 1.25804932072503 0.696969696969697 27.1 27 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.57360775014355e-12 1.03003166603302e-10 1.25804932072503 0.696969696969697 27.1 27 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.3469281457844e-07 1.38575881802954e-06 1.25707257435801 0.696428571428571 27.1 27 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 2.96259407986708e-06 1.45371426746581e-05 1.25567115565749 0.695652173913043 27.1 27 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.26886924602108e-07 7.68340824292766e-07 1.25434099553498 0.694915254237288 27.1 27 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 5.23750093831295e-30 8.28107092802147e-28 1.25422851875991 0.694852941176471 27.1 27 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 3.81732473985768e-05 0.000144086289252453 1.25349117101226 0.694444444444444 27.1 27 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 6.94204030883363e-18 3.52804405695366e-16 1.25317181020435 0.694267515923567 27.1 27 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 6.86348182958526e-08 4.32156400154859e-07 1.25187376304966 0.693548387096774 27.1 27 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.29259348899564e-45 4.59840133710199e-43 1.24996020996715 0.692488262910798 27.1 27 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000508968851607911 0.00146315692088496 1.24963427510145 0.692307692307692 27.1 27 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000508968851607911 0.00146315692088496 1.24963427510145 0.692307692307692 27.1 27 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000508968851607911 0.00146315692088496 1.24963427510145 0.692307692307692 27.1 27 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0143340271931701 0.0288097749941823 1.24963427510145 0.692307692307692 27.1 27 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0143340271931701 0.0288097749941823 1.24963427510145 0.692307692307692 27.1 27 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0143340271931701 0.0288097749941823 1.24963427510145 0.692307692307692 27.1 27 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.0143340271931701 0.0288097749941823 1.24963427510145 0.692307692307692 27.1 27 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0143340271931701 0.0288097749941823 1.24963427510145 0.692307692307692 27.1 27 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0143340271931701 0.0288097749941823 1.24963427510145 0.692307692307692 27.1 27 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0143340271931701 0.0288097749941823 1.24963427510145 0.692307692307692 27.1 27 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 7.43521971006336e-18 3.64838539566213e-16 1.24876101564995 0.691823899371069 27.1 27 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 4.62586827269116e-07 2.60182235258479e-06 1.24710976141438 0.690909090909091 27.1 27 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 4.62586827269116e-07 2.60182235258479e-06 1.24710976141438 0.690909090909091 27.1 27 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.81865533708724e-10 4.69653872922955e-09 1.24632836432076 0.69047619047619 27.1 27 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.81865533708724e-10 4.69653872922955e-09 1.24632836432076 0.69047619047619 27.1 27 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 1.09011908532182e-05 4.83252167729893e-05 1.24632836432076 0.69047619047619 27.1 27 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.64997884533961e-55 1.25697329897275e-52 1.2456747241664 0.690114068441065 27.1 27 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000268197777573328 0.000808570842133148 1.24484640431562 0.689655172413793 27.1 27 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 5.90077444459634e-09 4.79817259123462e-08 1.24400529188027 0.689189189189189 27.1 27 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 5.90077444459634e-09 4.79817259123462e-08 1.24400529188027 0.689189189189189 27.1 27 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 7.2737924002913e-08 4.53973973053268e-07 1.24095625930213 0.6875 27.1 27 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 7.2737924002913e-08 4.53973973053268e-07 1.24095625930213 0.6875 27.1 27 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 3.13289234080379e-06 1.53199512060611e-05 1.24095625930213 0.6875 27.1 27 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0001418548580507 0.000457731208630715 1.24095625930213 0.6875 27.1 27 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00725388012910132 0.0161820693023797 1.24095625930213 0.6875 27.1 27 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00725388012910132 0.0161820693023797 1.24095625930213 0.6875 27.1 27 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00725388012910132 0.0161820693023797 1.24095625930213 0.6875 27.1 27 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00725388012910132 0.0161820693023797 1.24095625930213 0.6875 27.1 27 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00725388012910132 0.0161820693023797 1.24095625930213 0.6875 27.1 27 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.68277954697247e-06 8.58277883635064e-06 1.23874421605917 0.686274509803922 27.1 27 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.12557609872923e-08 1.50231535250271e-07 1.23773299629096 0.685714285714286 27.1 27 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 9.04886823500917e-07 4.859071508837e-06 1.23677795539876 0.685185185185185 27.1 27 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 4.90586571939573e-14 1.42470345279594e-12 1.23651475515288 0.68503937007874 27.1 27 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.99402347658341e-12 4.2992354654215e-11 1.23587453833857 0.684684684684685 27.1 27 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 3.37018234205593e-09 2.87171824715305e-08 1.23381611972042 0.683544303797468 27.1 27 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.33176064647863e-19 1.38253974997462e-17 1.23294213542189 0.683060109289617 27.1 27 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00192542121114167 0.0048322299531827 1.2307004224484 0.681818181818182 27.1 27 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00192542121114167 0.0048322299531827 1.2307004224484 0.681818181818182 27.1 27 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.22760744468076e-08 1.50231535250271e-07 1.22842134759201 0.680555555555556 27.1 27 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00100396937959953 0.00268039104534734 1.2274185546552 0.68 27.1 27 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00100396937959953 0.00268039104534734 1.2274185546552 0.68 27.1 27 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00100396937959953 0.00268039104534734 1.2274185546552 0.68 27.1 27 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00100396937959953 0.00268039104534734 1.2274185546552 0.68 27.1 27 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 9.43696409616095e-07 5.0295130744708e-06 1.22483994424626 0.678571428571429 27.1 27 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000526486366934618 0.00150138296622838 1.22483994424626 0.678571428571429 27.1 27 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000526486366934618 0.00150138296622838 1.22483994424626 0.678571428571429 27.1 27 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.03360259100981e-09 9.55075640913607e-09 1.22409896424369 0.67816091954023 27.1 27 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.03360259100981e-09 9.55075640913607e-09 1.22409896424369 0.67816091954023 27.1 27 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.97979786241185e-17 9.39084119404022e-16 1.22104787011547 0.676470588235294 27.1 27 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.000146671510747801 0.000470075585121894 1.22104787011547 0.676470588235294 27.1 27 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000146671510747801 0.000470075585121894 1.22104787011547 0.676470588235294 27.1 27 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.67028800076864e-14 5.28182183354172e-13 1.2206659345915 0.676258992805755 27.1 27 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 2.62696745198265e-11 3.70116305363496e-10 1.22054226023136 0.676190476190476 27.1 27 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.13857335327589e-05 0.000154167274390356 1.21839341822391 0.675 27.1 27 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 4.13857335327589e-05 0.000154167274390356 1.21839341822391 0.675 27.1 27 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.7849663648657e-17 1.73742165716255e-15 1.21759237061167 0.674556213017751 27.1 27 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.98178176888087e-09 1.75159966280589e-08 1.21734398375516 0.674418604651163 27.1 27 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.98178176888087e-09 1.75159966280589e-08 1.21734398375516 0.674418604651163 27.1 27 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.17863436809512e-05 5.01599016723155e-05 1.2164314320432 0.673913043478261 27.1 27 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.17863436809512e-05 5.01599016723155e-05 1.2164314320432 0.673913043478261 27.1 27 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.14951987786711e-10 3.22429265194596e-09 1.21601838232094 0.673684210526316 27.1 27 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 6.30711470287389e-06 2.92346065869366e-05 1.21563062135719 0.673469387755102 27.1 27 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 5.02029378242596e-11 6.65056839725236e-10 1.21492221190419 0.673076923076923 27.1 27 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.72351232629664e-11 3.79956670619619e-10 1.2145978000986 0.672897196261682 27.1 27 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 9.74720157763768e-07 5.1371362388809e-06 1.21372524420773 0.672413793103448 27.1 27 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 9.74720157763768e-07 5.1371362388809e-06 1.21372524420773 0.672413793103448 27.1 27 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 2.82290412757169e-07 1.65308336359445e-06 1.21275270795436 0.671875 27.1 27 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.30328818298715e-14 1.00012320944483e-12 1.21194689220156 0.671428571428571 27.1 27 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.39130023485161e-08 1.6051038840537e-07 1.211268310515 0.671052631578947 27.1 27 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.29221298970498e-08 1.01034015623637e-07 1.21096767305893 0.670886075949367 27.1 27 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 6.98669384116814e-09 5.64890075908083e-08 1.2106890334655 0.670731707317073 27.1 27 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.04541964791699e-09 1.79668651789252e-08 1.21018874874092 0.670454545454545 27.1 27 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.76158098303362e-10 1.89903768095215e-09 1.20936828179262 0.67 27.1 27 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.52463904520981e-11 2.4001004507709e-10 1.20872362919039 0.669642857142857 27.1 27 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.267480831054e-14 1.78372504451797e-12 1.2076801267767 0.669064748201439 27.1 27 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.7810320282864e-16 1.94383102178616e-14 1.20704278651585 0.668711656441718 27.1 27 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 7.17823473523813e-35 1.70243800470731e-32 1.20656904161608 0.668449197860963 27.1 27 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.56587612818166e-11 2.4001004507709e-10 1.20335152417177 0.666666666666667 27.1 27 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.45868205524073e-06 1.67404917163523e-05 1.20335152417177 0.666666666666667 27.1 27 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00101844222529244 0.00269877707000213 1.20335152417177 0.666666666666667 27.1 27 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00101844222529244 0.00269877707000213 1.20335152417177 0.666666666666667 27.1 27 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.29468577640229e-20 3.42469902719112e-18 1.20335152417177 0.666666666666667 27.1 27 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.45253427217009e-08 1.63847712173617e-07 1.20335152417177 0.666666666666667 27.1 27 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.55915878997906e-07 9.32219730311011e-07 1.20335152417177 0.666666666666667 27.1 27 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.55915878997906e-07 9.32219730311011e-07 1.20335152417177 0.666666666666667 27.1 27 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.55915878997906e-07 9.32219730311011e-07 1.20335152417177 0.666666666666667 27.1 27 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 7.93587110931623e-05 0.000281614578268254 1.20335152417177 0.666666666666667 27.1 27 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 7.93587110931623e-05 0.000281614578268254 1.20335152417177 0.666666666666667 27.1 27 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000535040104700011 0.00151063902577007 1.20335152417177 0.666666666666667 27.1 27 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00194869661679969 0.00485638403801395 1.20335152417177 0.666666666666667 27.1 27 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00728932285511272 0.0161820693023797 1.20335152417177 0.666666666666667 27.1 27 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00728932285511272 0.0161820693023797 1.20335152417177 0.666666666666667 27.1 27 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00728932285511272 0.0161820693023797 1.20335152417177 0.666666666666667 27.1 27 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00728932285511272 0.0161820693023797 1.20335152417177 0.666666666666667 27.1 27 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0143184573779098 0.0288097749941823 1.20335152417177 0.666666666666667 27.1 27 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.028578156811939 0.0528178565594336 1.20335152417177 0.666666666666667 27.1 27 1 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.028578156811939 0.0528178565594336 1.20335152417177 0.666666666666667 27.1 27 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.028578156811939 0.0528178565594336 1.20335152417177 0.666666666666667 27.1 27 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.028578156811939 0.0528178565594336 1.20335152417177 0.666666666666667 27.1 27 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.028578156811939 0.0528178565594336 1.20335152417177 0.666666666666667 27.1 27 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.028578156811939 0.0528178565594336 1.20335152417177 0.666666666666667 27.1 27 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0584411111937828 0.0986497048976902 1.20335152417177 0.666666666666667 27.1 27 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0584411111937828 0.0986497048976902 1.20335152417177 0.666666666666667 27.1 27 1 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0584411111937828 0.0986497048976902 1.20335152417177 0.666666666666667 27.1 27 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0584411111937828 0.0986497048976902 1.20335152417177 0.666666666666667 27.1 27 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0584411111937828 0.0986497048976902 1.20335152417177 0.666666666666667 27.1 27 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.87814012462308e-09 3.28487702222538e-08 1.20335152417177 0.666666666666667 27.1 27 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.05917612329421e-14 3.42547187147197e-13 1.19939313100015 0.664473684210526 27.1 27 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.21327981985052e-13 3.38528859538686e-12 1.19905384015687 0.664285714285714 27.1 27 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.00239538456461e-10 1.13817234671e-09 1.19772838620835 0.663551401869159 27.1 27 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.14483818241273e-23 1.01819045848332e-21 1.19409497398583 0.661538461538462 27.1 27 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.020178781302e-10 1.13817234671e-09 1.19231160193166 0.660550458715596 27.1 27 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 6.53817353295909e-06 3.01804982437876e-05 1.19199915130222 0.660377358490566 27.1 27 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.37116589788162e-08 1.06041797428562e-07 1.1891944474168 0.658823529411765 27.1 27 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.37116589788162e-08 1.06041797428562e-07 1.1891944474168 0.658823529411765 27.1 27 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 8.00266338480318e-05 0.000283278358123754 1.1886765055843 0.658536585365854 27.1 27 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.000283533800468987 0.000844076564994495 1.18616078811217 0.657142857142857 27.1 27 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000283533800468987 0.000844076564994495 1.18616078811217 0.657142857142857 27.1 27 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000283533800468987 0.000844076564994495 1.18616078811217 0.657142857142857 27.1 27 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00101723468672106 0.00269877707000213 1.18260408409984 0.655172413793103 27.1 27 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00101723468672106 0.00269877707000213 1.18260408409984 0.655172413793103 27.1 27 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 8.70824489481514e-22 6.52201709753787e-20 1.18160420746987 0.654618473895582 27.1 27 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.05456376361242e-19 1.27114966766108e-17 1.18147240555046 0.654545454545455 27.1 27 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.92281793418459e-10 2.04191785100349e-09 1.18147240555046 0.654545454545455 27.1 27 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 6.57480987742387e-06 3.01804982437876e-05 1.18147240555046 0.654545454545455 27.1 27 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 4.72352631670611e-08 3.02773781471747e-07 1.1810672366871 0.654320987654321 27.1 27 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00193897037691702 0.00484062253746127 1.18021014870692 0.653846153846154 27.1 27 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00193897037691702 0.00484062253746127 1.18021014870692 0.653846153846154 27.1 27 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00193897037691702 0.00484062253746127 1.18021014870692 0.653846153846154 27.1 27 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 9.17091390779591e-12 1.54477420682757e-10 1.1796635020424 0.653543307086614 27.1 27 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 2.28533993093854e-05 9.23874636853847e-05 1.17879332980091 0.653061224489796 27.1 27 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.2700597991178e-05 0.000157416971350897 1.1771917084289 0.652173913043478 27.1 27 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.67311096575609e-72 1.23418369042709e-68 1.17204260442522 0.649321266968326 27.1 27 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000281711278826067 0.000843947683725248 1.17082851000496 0.648648648648649 27.1 27 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000281711278826067 0.000843947683725248 1.17082851000496 0.648648648648649 27.1 27 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 5.52870580089595e-07 3.0731829510449e-06 1.16945429813876 0.647887323943662 27.1 27 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000530888127600931 0.00150189623374975 1.16795883228436 0.647058823529412 27.1 27 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000530888127600931 0.00150189623374975 1.16795883228436 0.647058823529412 27.1 27 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000530888127600931 0.00150189623374975 1.16795883228436 0.647058823529412 27.1 27 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000530888127600931 0.00150189623374975 1.16795883228436 0.647058823529412 27.1 27 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0139676036535086 0.0283941428556325 1.16795883228436 0.647058823529412 27.1 27 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0139676036535086 0.0283941428556325 1.16795883228436 0.647058823529412 27.1 27 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0139676036535086 0.0283941428556325 1.16795883228436 0.647058823529412 27.1 27 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0139676036535086 0.0283941428556325 1.16795883228436 0.647058823529412 27.1 27 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0139676036535086 0.0283941428556325 1.16795883228436 0.647058823529412 27.1 27 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0139676036535086 0.0283941428556325 1.16795883228436 0.647058823529412 27.1 27 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 9.22739336474656e-12 1.54477420682757e-10 1.1671605008884 0.646616541353383 27.1 27 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 4.0861327030438e-09 3.44057209256292e-08 1.16688632646959 0.646464646464647 27.1 27 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 8.72414092143944e-08 5.42115831057132e-07 1.16666397770311 0.646341463414634 27.1 27 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 4.23929449192514e-05 0.000156688728883363 1.1657467890414 0.645833333333333 27.1 27 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 5.49208498339225e-07 3.06479879661458e-06 1.16214085553575 0.643835616438356 27.1 27 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000148030421651941 0.000472303340831194 1.16037468402277 0.642857142857143 27.1 27 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000148030421651941 0.000472303340831194 1.16037468402277 0.642857142857143 27.1 27 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0275333380801492 0.0521516949203518 1.16037468402277 0.642857142857143 27.1 27 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 2.24703152561981e-05 9.10976028762673e-05 1.15794203269359 0.641509433962264 27.1 27 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000277354597605779 0.000834409286243179 1.15706877324208 0.641025641025641 27.1 27 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.28581487335863e-13 3.51868185536409e-12 1.15565771376252 0.640243902439024 27.1 27 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 4.17948858135245e-05 0.000154880527376681 1.1552174632049 0.64 27.1 27 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 4.17948858135245e-05 0.000154880527376681 1.1552174632049 0.64 27.1 27 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.00362821170515556 0.00864814950826862 1.1552174632049 0.64 27.1 27 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00362821170515556 0.00864814950826862 1.1552174632049 0.64 27.1 27 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00362821170515556 0.00864814950826862 1.1552174632049 0.64 27.1 27 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.00203286782017e-06 5.26159694062031e-06 1.15321187733128 0.638888888888889 27.1 27 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00052076110658327 0.00149103230315492 1.15321187733128 0.638888888888889 27.1 27 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00052076110658327 0.00149103230315492 1.15321187733128 0.638888888888889 27.1 27 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.05458451826094e-14 6.35581254235938e-13 1.15236205280856 0.638418079096045 27.1 27 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.84964599581781e-06 9.40016518588836e-06 1.15103189268604 0.63768115942029 27.1 27 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.000980170773911942 0.00266179963984102 1.1486537276185 0.636363636363636 27.1 27 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0552209368583632 0.0957118065157744 1.1486537276185 0.636363636363636 27.1 27 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0552209368583632 0.0957118065157744 1.1486537276185 0.636363636363636 27.1 27 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0552209368583632 0.0957118065157744 1.1486537276185 0.636363636363636 27.1 27 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0552209368583632 0.0957118065157744 1.1486537276185 0.636363636363636 27.1 27 1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0552209368583632 0.0957118065157744 1.1486537276185 0.636363636363636 27.1 27 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.40243088314163e-12 3.11821741673521e-11 1.14549808550966 0.634615384615385 27.1 27 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 4.09531878023103e-05 0.000153358911164967 1.14549808550966 0.634615384615385 27.1 27 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 4.09531878023103e-05 0.000153358911164967 1.14549808550966 0.634615384615385 27.1 27 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 4.09531878023103e-05 0.000153358911164967 1.14549808550966 0.634615384615385 27.1 27 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.36766410163266e-10 3.37477888494597e-09 1.14465144982192 0.634146341463415 27.1 27 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.36766410163266e-10 3.37477888494597e-09 1.14465144982192 0.634146341463415 27.1 27 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 9.88910781738323e-11 1.13817234671e-09 1.14364324243805 0.633587786259542 27.1 27 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 9.88910781738323e-11 1.13817234671e-09 1.14364324243805 0.633587786259542 27.1 27 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 3.34486626403496e-06 1.62448624359104e-05 1.14141431336881 0.632352941176471 27.1 27 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.51666574055692e-12 5.26649316001838e-11 1.14124305840806 0.632258064516129 27.1 27 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 9.64323214277861e-07 5.12026841013954e-06 1.14001723342588 0.631578947368421 27.1 27 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000506757772470314 0.00146315692088496 1.14001723342588 0.631578947368421 27.1 27 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0134091246768144 0.0280605653163337 1.14001723342588 0.631578947368421 27.1 27 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0035038682346788 0.00845085508126769 1.13649866171778 0.62962962962963 27.1 27 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 1.13718530221319e-05 4.9451082697401e-05 1.13542038974271 0.629032258064516 27.1 27 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 8.67436646053146e-16 3.33611445225305e-14 1.13458857993338 0.628571428571429 27.1 27 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 4.2937359929807e-12 8.30597064188709e-11 1.13099810974372 0.626582278481013 27.1 27 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000136886990838581 0.000442704972643865 1.12814205391103 0.625 27.1 27 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000489812335058893 0.00141955794865337 1.12814205391103 0.625 27.1 27 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00178269510992233 0.00452188082249461 1.12814205391103 0.625 27.1 27 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00666229554843839 0.0150483278816315 1.12814205391103 0.625 27.1 27 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00666229554843839 0.0150483278816315 1.12814205391103 0.625 27.1 27 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0260927527925905 0.0497054715178799 1.12814205391103 0.625 27.1 27 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0260927527925905 0.0497054715178799 1.12814205391103 0.625 27.1 27 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0260927527925905 0.0497054715178799 1.12814205391103 0.625 27.1 27 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.113734307266739 0.180026606496741 1.12814205391103 0.625 27.1 27 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.113734307266739 0.180026606496741 1.12814205391103 0.625 27.1 27 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.113734307266739 0.180026606496741 1.12814205391103 0.625 27.1 27 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.113734307266739 0.180026606496741 1.12814205391103 0.625 27.1 27 1 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.113734307266739 0.180026606496741 1.12814205391103 0.625 27.1 27 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000253754254812169 0.000768281499144077 1.12312808922698 0.622222222222222 27.1 27 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 3.73812732859275e-05 0.000141472212462433 1.12036176388406 0.620689655172414 27.1 27 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 3.73812732859275e-05 0.000141472212462433 1.12036176388406 0.620689655172414 27.1 27 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 3.73812732859275e-05 0.000141472212462433 1.12036176388406 0.620689655172414 27.1 27 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0127286784512841 0.0266758607307471 1.11739784387378 0.619047619047619 27.1 27 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.26073753526418e-11 2.03866990077379e-10 1.11686063337192 0.61875 27.1 27 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 2.96231227250843e-06 1.45371426746581e-05 1.11626687439618 0.618421052631579 27.1 27 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 8.343130723975e-22 6.52201709753787e-20 1.11291559674168 0.616564417177914 27.1 27 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.8838884112526e-05 7.74789944859089e-05 1.1107860223124 0.615384615384615 27.1 27 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000126592846826948 0.000411282239805359 1.1107860223124 0.615384615384615 27.1 27 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0513687642019694 0.0898006774685534 1.1107860223124 0.615384615384615 27.1 27 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0513687642019694 0.0898006774685534 1.1107860223124 0.615384615384615 27.1 27 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0513687642019694 0.0898006774685534 1.1107860223124 0.615384615384615 27.1 27 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 9.88777324693801e-06 4.39696916574774e-05 1.10880247584398 0.614285714285714 27.1 27 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.20761915217387e-18 1.16349705686793e-16 1.10777847893069 0.613718411552347 27.1 27 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00319051885713062 0.00773442646285669 1.10630704641598 0.612903225806452 27.1 27 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00319051885713062 0.00773442646285669 1.10630704641598 0.612903225806452 27.1 27 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00319051885713062 0.00773442646285669 1.10630704641598 0.612903225806452 27.1 27 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000232954263877363 0.000722208970582761 1.10511874668836 0.612244897959184 27.1 27 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 9.66146163035864e-09 7.63792216666686e-08 1.10390098498402 0.611570247933884 27.1 27 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 9.66146163035864e-09 7.63792216666686e-08 1.10390098498402 0.611570247933884 27.1 27 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 6.30567963463884e-05 0.000227164104306103 1.10137258144534 0.610169491525424 27.1 27 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 7.69007227842407e-10 7.24700188887249e-09 1.10093862849757 0.609929078014184 27.1 27 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000831770600209086 0.00227180338598374 1.10062639405954 0.609756097560976 27.1 27 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000831770600209086 0.00227180338598374 1.10062639405954 0.609756097560976 27.1 27 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.52268118407353e-12 3.3335004999025e-11 1.10039096595386 0.609625668449198 27.1 27 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.011983872653534 0.0254523146059385 1.09871226120031 0.608695652173913 27.1 27 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.011983872653534 0.0254523146059385 1.09871226120031 0.608695652173913 27.1 27 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 7.36896161228205e-10 7.08515700964686e-09 1.09816345387703 0.608391608391608 27.1 27 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 3.13941444976127e-05 0.000122394157863296 1.09395593106524 0.606060606060606 27.1 27 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00153713550203169 0.00402085260917479 1.09251651536647 0.605263157894737 27.1 27 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000788458887943361 0.00217016827377834 1.09141184750462 0.604651162790698 27.1 27 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.000788458887943361 0.00217016827377834 1.09141184750462 0.604651162790698 27.1 27 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000210620152462834 0.000657264203847835 1.08982779547632 0.60377358490566 27.1 27 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 7.73034365496781e-12 1.35805913839743e-10 1.08890233029673 0.603260869565217 27.1 27 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00144978862804557 0.00379935399209732 1.08301637175459 0.6 27.1 27 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00561225654804114 0.0129857578339228 1.08301637175459 0.6 27.1 27 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00561225654804114 0.0129857578339228 1.08301637175459 0.6 27.1 27 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0112134213133626 0.0238872732468787 1.08301637175459 0.6 27.1 27 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0112134213133626 0.0238872732468787 1.08301637175459 0.6 27.1 27 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0112134213133626 0.0238872732468787 1.08301637175459 0.6 27.1 27 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0112134213133626 0.0238872732468787 1.08301637175459 0.6 27.1 27 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0112134213133626 0.0238872732468787 1.08301637175459 0.6 27.1 27 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0112134213133626 0.0238872732468787 1.08301637175459 0.6 27.1 27 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0112134213133626 0.0238872732468787 1.08301637175459 0.6 27.1 27 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0112134213133626 0.0238872732468787 1.08301637175459 0.6 27.1 27 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.0227642945188175 0.0442535397544772 1.08301637175459 0.6 27.1 27 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0473556591335084 0.0836068274776458 1.08301637175459 0.6 27.1 27 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0473556591335084 0.0836068274776458 1.08301637175459 0.6 27.1 27 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.102786939189756 0.163975128326259 1.08301637175459 0.6 27.1 27 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.102786939189756 0.163975128326259 1.08301637175459 0.6 27.1 27 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.102786939189756 0.163975128326259 1.08301637175459 0.6 27.1 27 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.102786939189756 0.163975128326259 1.08301637175459 0.6 27.1 27 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.102786939189756 0.163975128326259 1.08301637175459 0.6 27.1 27 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.102786939189756 0.163975128326259 1.08301637175459 0.6 27.1 27 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.25262604316078e-08 9.84799369844079e-08 1.08028148192693 0.598484848484849 27.1 27 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.67053411102666e-06 1.75864311110806e-05 1.07490388956916 0.595505617977528 27.1 27 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0104431863331131 0.022550309790622 1.06964579926379 0.592592592592593 27.1 27 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0104431863331131 0.022550309790622 1.06964579926379 0.592592592592593 27.1 27 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0104431863331131 0.022550309790622 1.06964579926379 0.592592592592593 27.1 27 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.25159147987866e-05 5.26927418895662e-05 1.06964579926379 0.592592592592593 27.1 27 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 1.25159147987866e-05 5.26927418895662e-05 1.06964579926379 0.592592592592593 27.1 27 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.38330390129508e-05 9.60748286556061e-05 1.06876615633677 0.592105263157895 27.1 27 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 6.20480555914368e-06 2.88543735642531e-05 1.06660703278861 0.590909090909091 27.1 27 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0210735859156734 0.0410228628700455 1.06660703278861 0.590909090909091 27.1 27 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0210735859156734 0.0410228628700455 1.06660703278861 0.590909090909091 27.1 27 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0210735859156734 0.0410228628700455 1.06660703278861 0.590909090909091 27.1 27 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 4.5672676815706e-11 6.13134142535374e-10 1.06233376743289 0.588541666666667 27.1 27 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.10865293982755e-05 4.83930409010614e-05 1.06178075662215 0.588235294117647 27.1 27 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.10865293982755e-05 4.83930409010614e-05 1.06178075662215 0.588235294117647 27.1 27 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.10865293982755e-05 4.83930409010614e-05 1.06178075662215 0.588235294117647 27.1 27 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.10865293982755e-05 4.83930409010614e-05 1.06178075662215 0.588235294117647 27.1 27 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.10865293982755e-05 4.83930409010614e-05 1.06178075662215 0.588235294117647 27.1 27 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00489079491431326 0.0114279165239208 1.06178075662215 0.588235294117647 27.1 27 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00489079491431326 0.0114279165239208 1.06178075662215 0.588235294117647 27.1 27 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0434143944198503 0.078399344237877 1.06178075662215 0.588235294117647 27.1 27 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0434143944198503 0.078399344237877 1.06178075662215 0.588235294117647 27.1 27 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 4.87876541795467e-28 5.34037168442269e-26 1.06138308592678 0.588014981273408 27.1 27 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00232228466734413 0.00573717201671997 1.05660133829716 0.585365853658537 27.1 27 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0194340806006678 0.0381444092341383 1.05293258365029 0.583333333333333 27.1 27 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.092520828923357 0.149102083304572 1.05293258365029 0.583333333333333 27.1 27 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.092520828923357 0.149102083304572 1.05293258365029 0.583333333333333 27.1 27 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.092520828923357 0.149102083304572 1.05293258365029 0.583333333333333 27.1 27 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.04313470126929e-38 2.96876135981239e-36 1.05158439852398 0.58258642765685 27.1 27 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00216032929180346 0.005346345360411 1.04943446875445 0.581395348837209 27.1 27 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.93796755387707e-07 1.70692380806956e-06 1.04808035976251 0.580645161290323 27.1 27 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00896543181237871 0.0197184072164063 1.04808035976251 0.580645161290323 27.1 27 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00896543181237871 0.0197184072164063 1.04808035976251 0.580645161290323 27.1 27 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.69861241666303e-06 1.76614948621191e-05 1.04136189591787 0.576923076923077 27.1 27 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0178712715174881 0.0352227415088443 1.04136189591787 0.576923076923077 27.1 27 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.41241397880818e-05 5.84263108094198e-05 1.03985267577886 0.576086956521739 27.1 27 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00827556669985647 0.0182575680835593 1.03925813451198 0.575757575757576 27.1 27 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 7.5168956140722e-10 7.17888755625821e-09 1.03413021608511 0.572916666666667 27.1 27 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00762438015392134 0.0168608426413397 1.0314441635758 0.571428571428571 27.1 27 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0361451159421954 0.0658572342967274 1.0314441635758 0.571428571428571 27.1 27 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0831493323643963 0.134916191510303 1.0314441635758 0.571428571428571 27.1 27 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0831493323643963 0.134916191510303 1.0314441635758 0.571428571428571 27.1 27 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0831493323643963 0.134916191510303 1.0314441635758 0.571428571428571 27.1 27 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0831493323643963 0.134916191510303 1.0314441635758 0.571428571428571 27.1 27 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0831493323643963 0.134916191510303 1.0314441635758 0.571428571428571 27.1 27 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.28872333329162e-06 6.62040903709018e-06 1.0293130805932 0.570247933884298 27.1 27 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 5.24541331108388e-06 2.47159706677893e-05 1.02903424730576 0.570093457943925 27.1 27 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.3554735725869e-08 4.05553313622922e-07 1.02478968510112 0.567741935483871 27.1 27 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 6.23520133112189e-12 1.10908643677331e-10 1.0242813568843 0.567460317460317 27.1 27 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 6.23520133112189e-12 1.10908643677331e-10 1.0242813568843 0.567460317460317 27.1 27 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 6.23520133112189e-12 1.10908643677331e-10 1.0242813568843 0.567460317460317 27.1 27 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 7.44965285141003e-28 7.57204000539748e-26 1.02181949019873 0.566096423017107 27.1 27 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.93568082282291e-06 9.80239790347686e-06 1.02087608812933 0.565573770491803 27.1 27 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00644353220096875 0.0146538009481699 1.01822052045303 0.564102564102564 27.1 27 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0746936815718315 0.122594127885486 1.01532784851993 0.5625 27.1 27 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0746936815718315 0.122594127885486 1.01532784851993 0.5625 27.1 27 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0746936815718315 0.122594127885486 1.01532784851993 0.5625 27.1 27 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 2.46420563292905e-06 1.22607154393638e-05 1.00910974271097 0.559055118110236 27.1 27 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00105751228990029 0.00279191092491302 1.00608078250426 0.557377049180328 27.1 27 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0671048313094998 0.110649101915896 1.0027929368098 0.555555555555556 27.1 27 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0671048313094998 0.110649101915896 1.0027929368098 0.555555555555556 27.1 27 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.182850802357935 0.261241658388897 1.0027929368098 0.555555555555556 27.1 27 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.182850802357935 0.261241658388897 1.0027929368098 0.555555555555556 27.1 27 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.182850802357935 0.261241658388897 1.0027929368098 0.555555555555556 27.1 27 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.182850802357935 0.261241658388897 1.0027929368098 0.555555555555556 27.1 27 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.182850802357935 0.261241658388897 1.0027929368098 0.555555555555556 27.1 27 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.182850802357935 0.261241658388897 1.0027929368098 0.555555555555556 27.1 27 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.182850802357935 0.261241658388897 1.0027929368098 0.555555555555556 27.1 27 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.182850802357935 0.261241658388897 1.0027929368098 0.555555555555556 27.1 27 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0104722724532316 0.0225788540923463 0.997515079247648 0.552631578947368 27.1 27 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.73834108058352e-58 3.37132967883517e-55 0.996319128308773 0.551969012265978 27.1 27 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0246556072776975 0.0472206314349443 0.995877123452496 0.551724137931034 27.1 27 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.060309884979647 0.0997918213093461 0.992765007441707 0.55 27.1 27 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.060309884979647 0.0997918213093461 0.992765007441707 0.55 27.1 27 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.060309884979647 0.0997918213093461 0.992765007441707 0.55 27.1 27 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 7.39017308839889e-07 4.01382301709604e-06 0.988741061262151 0.547770700636943 27.1 27 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00318383847947598 0.00773442646285669 0.984560337958717 0.545454545454545 27.1 27 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0203079875406042 0.0396954207009338 0.984560337958717 0.545454545454545 27.1 27 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0203079875406042 0.0396954207009338 0.984560337958717 0.545454545454545 27.1 27 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0203079875406042 0.0396954207009338 0.984560337958717 0.545454545454545 27.1 27 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.159866141987428 0.231423723344975 0.984560337958717 0.545454545454545 27.1 27 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0184274892122638 0.0362687650747598 0.979871955397009 0.542857142857143 27.1 27 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00659624200772573 0.0149465802181429 0.97772311338956 0.541666666666667 27.1 27 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00659624200772573 0.0149465802181429 0.97772311338956 0.541666666666667 27.1 27 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0487929152678391 0.0858248682646911 0.97772311338956 0.541666666666667 27.1 27 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0487929152678391 0.0858248682646911 0.97772311338956 0.541666666666667 27.1 27 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0487929152678391 0.0858248682646911 0.97772311338956 0.541666666666667 27.1 27 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00547506201442674 0.0127386770717135 0.971937769523349 0.538461538461538 27.1 27 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.140531571098309 0.207014933408793 0.971937769523349 0.538461538461538 27.1 27 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.140531571098309 0.207014933408793 0.971937769523349 0.538461538461538 27.1 27 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.140531571098309 0.207014933408793 0.971937769523349 0.538461538461538 27.1 27 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.140531571098309 0.207014933408793 0.971937769523349 0.538461538461538 27.1 27 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.140531571098309 0.207014933408793 0.971937769523349 0.538461538461538 27.1 27 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 8.52245566973402e-05 0.000290826245036727 0.968150998992739 0.536363636363636 27.1 27 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.000221901226544332 0.000690952834513313 0.967643493663894 0.536082474226804 27.1 27 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 8.91556835866953e-19 4.8795591439949e-17 0.967317599990964 0.535901926444834 27.1 27 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.59944502571384e-15 1.853025644556e-13 0.967267985236722 0.535874439461883 27.1 27 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0395689269554401 0.0717281312835558 0.966978903352312 0.535714285714286 27.1 27 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0395689269554401 0.0717281312835558 0.966978903352312 0.535714285714286 27.1 27 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.035664398425225 0.0650646653321733 0.962681219337413 0.533333333333333 27.1 27 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.124056387485411 0.192593674011549 0.962681219337413 0.533333333333333 27.1 27 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.124056387485411 0.192593674011549 0.962681219337413 0.533333333333333 27.1 27 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.124056387485411 0.192593674011549 0.962681219337413 0.533333333333333 27.1 27 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 4.69627543754657e-16 1.94383102178616e-14 0.962681219337412 0.533333333333333 27.1 27 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 2.93883579042193e-07 1.70692380806956e-06 0.962070381000269 0.532994923857868 27.1 27 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0321631559963878 0.0587524659600254 0.958920745824376 0.53125 27.1 27 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000890757782053261 0.00242825349398811 0.956881934883573 0.530120481927711 27.1 27 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 7.28738474180706e-30 9.4272258978104e-28 0.955815249679976 0.529529529529529 27.1 27 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.10988287961781 0.174903062299937 0.955602680959932 0.529411764705882 27.1 27 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00635768618260293 0.0145449958807781 0.950014361188236 0.526315789473684 27.1 27 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0975992991798432 0.156753727689522 0.950014361188236 0.526315789473684 27.1 27 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0868911309208439 0.140666756883232 0.945490483277816 0.523809523809524 27.1 27 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0775117579568222 0.126635168280778 0.941753366743121 0.521739130434783 27.1 27 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0775117579568222 0.126635168280778 0.941753366743121 0.521739130434783 27.1 27 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0619865246876762 0.102446950790434 0.935940074355818 0.518518518518518 27.1 27 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.20881714294841e-13 5.71481235348289e-12 0.931863680303745 0.516260162601626 27.1 27 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0498360977038261 0.0874436091646665 0.93162698645556 0.516129032258065 27.1 27 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0498360977038261 0.0874436091646665 0.93162698645556 0.516129032258065 27.1 27 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 2.76812140771711e-05 0.000110028959865404 0.930894575302687 0.515723270440252 27.1 27 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 2.76812140771711e-05 0.000110028959865404 0.930894575302687 0.515723270440252 27.1 27 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 2.52730698496973e-05 0.000101390193536692 0.930542017139036 0.515527950310559 27.1 27 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 3.38118311163395e-05 0.000130038474806895 0.924797930613486 0.512345679012346 27.1 27 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00154747561339446 0.00404047302359691 0.921716061067735 0.51063829787234 27.1 27 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0675090394112643 0.111186762826654 0.902513643128824 0.5 27.1 27 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0754305690808182 0.123518641889533 0.902513643128824 0.5 27.1 27 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0754305690808182 0.123518641889533 0.902513643128824 0.5 27.1 27 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.17341909339899 0.250025704059537 0.902513643128824 0.5 27.1 27 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.17341909339899 0.250025704059537 0.902513643128824 0.5 27.1 27 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.17341909339899 0.250025704059537 0.902513643128824 0.5 27.1 27 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.17341909339899 0.250025704059537 0.902513643128824 0.5 27.1 27 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0260211145955686 0.0497054715178799 0.902513643128824 0.5 27.1 27 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0946010995929126 0.152282086788139 0.902513643128824 0.5 27.1 27 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.134888713380039 0.19994441577062 0.902513643128824 0.5 27.1 27 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.134888713380039 0.19994441577062 0.902513643128824 0.5 27.1 27 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.134888713380039 0.19994441577062 0.902513643128824 0.5 27.1 27 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.15266092792612 0.224417872354203 0.902513643128824 0.5 27.1 27 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.197913809832222 0.281069212965321 0.902513643128824 0.5 27.1 27 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.197913809832222 0.281069212965321 0.902513643128824 0.5 27.1 27 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.197913809832222 0.281069212965321 0.902513643128824 0.5 27.1 27 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.197913809832222 0.281069212965321 0.902513643128824 0.5 27.1 27 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.197913809832222 0.281069212965321 0.902513643128824 0.5 27.1 27 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.197913809832222 0.281069212965321 0.902513643128824 0.5 27.1 27 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.262914665526115 0.358703326024603 0.902513643128824 0.5 27.1 27 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.262914665526115 0.358703326024603 0.902513643128824 0.5 27.1 27 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.262914665526115 0.358703326024603 0.902513643128824 0.5 27.1 27 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.262914665526115 0.358703326024603 0.902513643128824 0.5 27.1 27 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.262914665526115 0.358703326024603 0.902513643128824 0.5 27.1 27 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.262914665526115 0.358703326024603 0.902513643128824 0.5 27.1 27 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.227211455051499 0.317411578993412 0.902513643128824 0.5 27.1 27 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.227211455051499 0.317411578993412 0.902513643128824 0.5 27.1 27 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.227211455051499 0.317411578993412 0.902513643128824 0.5 27.1 27 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.227211455051499 0.317411578993412 0.902513643128824 0.5 27.1 27 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.227211455051499 0.317411578993412 0.902513643128824 0.5 27.1 27 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.227211455051499 0.317411578993412 0.902513643128824 0.5 27.1 27 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000230391474881114 0.000715823294226692 0.896690974463477 0.496774193548387 27.1 27 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00763062730922188 0.0168608426413397 0.891371499386493 0.493827160493827 27.1 27 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0185474483331773 0.0364544461023637 0.888188029745827 0.492063492063492 27.1 27 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0277838945297365 0.0521516949203518 0.886104304162846 0.490909090909091 27.1 27 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000288848130394253 0.000858102065868523 0.885902962580441 0.49079754601227 27.1 27 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 7.6355073349712e-06 3.48399443154687e-05 0.884817297185122 0.490196078431373 27.1 27 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0378183805292158 0.0687299559298519 0.884094997350685 0.489795918367347 27.1 27 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0465928850626492 0.0824647704529226 0.882457784392628 0.488888888888889 27.1 27 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00102188062784002 0.00270285526657315 0.877090723604069 0.485915492957746 27.1 27 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00112161020319733 0.00295565059101814 0.876727539039429 0.485714285714286 27.1 27 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0177381283574677 0.0350088164392185 0.876727539039429 0.485714285714286 27.1 27 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0889205847577177 0.143788627397991 0.875164744852193 0.484848484848485 27.1 27 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00170888356917617 0.00435016336124809 0.869575189000035 0.481751824817518 27.1 27 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00170888356917617 0.00435016336124809 0.869575189000035 0.481751824817518 27.1 27 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0396500256267935 0.0717836977950727 0.869087211901831 0.481481481481481 27.1 27 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00736308863309052 0.016320366238143 0.866413097403671 0.48 27.1 27 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.14035382514074 0.207014933408793 0.866413097403671 0.48 27.1 27 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0540339641831669 0.0942283468537334 0.864908907998456 0.479166666666667 27.1 27 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0540339641831669 0.0942283468537334 0.864908907998456 0.479166666666667 27.1 27 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0599813162265279 0.0996860326640091 0.863273919514528 0.478260869565217 27.1 27 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0599813162265279 0.0996860326640091 0.863273919514528 0.478260869565217 27.1 27 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.15808756578594 0.231423723344975 0.863273919514528 0.478260869565217 27.1 27 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00235530564138027 0.00578391212652021 0.862696864755494 0.477941176470588 27.1 27 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000107557487118179 0.000356314779115457 0.859905702895275 0.476394849785408 27.1 27 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.178522879252035 0.257123539651463 0.859536802979833 0.476190476190476 27.1 27 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0122944038531471 0.0260729309732165 0.855012925069413 0.473684210526316 27.1 27 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.20221639379777 0.286607498380704 0.855012925069412 0.473684210526316 27.1 27 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.142755099258677 0.210072912352738 0.842346066920236 0.466666666666667 27.1 27 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.262539054385682 0.358703326024603 0.842346066920236 0.466666666666667 27.1 27 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.262539054385682 0.358703326024603 0.842346066920236 0.466666666666667 27.1 27 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0841632204723273 0.136405766209706 0.842346066920236 0.466666666666667 27.1 27 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.301508498439947 0.403239279398538 0.833089516734299 0.461538461538462 27.1 27 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.301508498439947 0.403239279398538 0.833089516734299 0.461538461538462 27.1 27 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.159808771211674 0.231423723344975 0.820466948298931 0.454545454545455 27.1 27 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.159808771211674 0.231423723344975 0.820466948298931 0.454545454545455 27.1 27 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.227665853739009 0.317411578993412 0.820466948298931 0.454545454545455 27.1 27 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.227665853739009 0.317411578993412 0.820466948298931 0.454545454545455 27.1 27 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.348788435141687 0.46255912694 0.820466948298931 0.454545454545455 27.1 27 1 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.348788435141687 0.46255912694 0.820466948298931 0.454545454545455 27.1 27 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0366999225032014 0.0667825955525008 0.815173613148615 0.451612903225806 27.1 27 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.257302677775913 0.353760106739251 0.812262278815942 0.45 27.1 27 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.199485067026791 0.283018195791748 0.809150162805153 0.448275862068966 27.1 27 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.223317955066047 0.314013290572119 0.802234349447844 0.444444444444444 27.1 27 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.291683567827176 0.390834008491593 0.802234349447844 0.444444444444444 27.1 27 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.291683567827176 0.390834008491593 0.802234349447844 0.444444444444444 27.1 27 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.291683567827176 0.390834008491593 0.802234349447844 0.444444444444444 27.1 27 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.291683567827176 0.390834008491593 0.802234349447844 0.444444444444444 27.1 27 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0576013819833953 0.0980085443034504 0.799955274591458 0.443181818181818 27.1 27 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.331854579597552 0.441335576418053 0.789699437737721 0.4375 27.1 27 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0800228888622919 0.130587810608992 0.782178490711648 0.433333333333333 27.1 27 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.235234221326449 0.3275325801835 0.773583122681849 0.428571428571429 27.1 27 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.157593761157314 0.23119167229573 0.76935589250326 0.426229508196721 27.1 27 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.120001363620373 0.189524906139612 0.764482144767945 0.423529411764706 27.1 27 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.120001363620373 0.189524906139612 0.764482144767945 0.423529411764706 27.1 27 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0949144591567079 0.15261387048587 0.763665390339774 0.423076923076923 27.1 27 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.302300979779502 0.403919525095052 0.763665390339774 0.423076923076923 27.1 27 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.356750603484925 0.465739549320228 0.760011488950589 0.421052631578947 27.1 27 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.356750603484925 0.465739549320228 0.760011488950589 0.421052631578947 27.1 27 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.206341345098733 0.292162919478107 0.754829592435017 0.418181818181818 27.1 27 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.337774097569893 0.448788553540577 0.752094702607353 0.416666666666667 27.1 27 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.435629135206107 0.558468702160622 0.752094702607353 0.416666666666667 27.1 27 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.266471627673524 0.363207975267648 0.748425947960488 0.414634146341463 27.1 27 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.403225775806033 0.519737571532595 0.743246529635502 0.411764705882353 27.1 27 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.456981488569114 0.574456411867358 0.722010914503059 0.4 27.1 27 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.104635907992257 0.166737846666274 0.714932376125578 0.396078431372549 27.1 27 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.156800260644387 0.230264985445782 0.712254010253018 0.394594594594595 27.1 27 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.316103377147736 0.420781202695256 0.710174670003009 0.39344262295082 27.1 27 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.41210211200659 0.529261105943481 0.709117862458362 0.392857142857143 27.1 27 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.374358412514283 0.482966474168472 0.699908539569292 0.387755102040816 27.1 27 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.415056738569814 0.532575057695984 0.694241263945249 0.384615384615385 27.1 27 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.454625501301265 0.572000078118214 0.694241263945249 0.384615384615385 27.1 27 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.479380391654308 0.601550526740812 0.676885232346618 0.375 27.1 27 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.532057633952051 0.662395462041792 0.676885232346618 0.375 27.1 27 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.464069740312433 0.582851933331503 0.662604953183187 0.367088607594937 27.1 27 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.522230032344043 0.650729716309609 0.661843338294471 0.366666666666667 27.1 27 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.227742250282694 0.317411578993412 0.657734333089982 0.364390243902439 27.1 27 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.597371210012299 0.715538073945708 0.644652602234874 0.357142857142857 27.1 27 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.597371210012299 0.715538073945708 0.644652602234874 0.357142857142857 27.1 27 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.602329556577151 0.7208704449195 0.637068453973288 0.352941176470588 27.1 27 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.587411772229623 0.707441556767509 0.634198776252687 0.351351351351351 27.1 27 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.62333253658909 0.745379999635525 0.627357044613939 0.347560975609756 27.1 27 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.630167295977944 0.752920287301943 0.620478129651067 0.34375 27.1 27 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.666401692657324 0.794212402555589 0.601675762085883 0.333333333333333 27.1 27 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.666401692657324 0.794212402555589 0.601675762085883 0.333333333333333 27.1 27 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.666390744423982 0.794212402555589 0.601675762085883 0.333333333333333 27.1 27 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.669973468212936 0.797801042064442 0.601675762085883 0.333333333333333 27.1 27 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.732087997952747 0.847271912008422 0.59405961319872 0.329113924050633 27.1 27 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.715162681710873 0.843844524108269 0.585414255002481 0.324324324324324 27.1 27 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.78620825570136 0.895736067144143 0.583443163234795 0.323232323232323 27.1 27 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.751404448026436 0.861884703614754 0.576072538167335 0.319148936170213 27.1 27 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.780687440916447 0.890872677164478 0.575515946343018 0.318840579710145 27.1 27 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.719767938948193 0.847271912008422 0.574326863809252 0.318181818181818 27.1 27 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.940006896773476 1 0.557312572254666 0.308755760368664 27.1 27 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.773312669777452 0.884585152004271 0.541508185877295 0.3 27.1 27 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.773312669777452 0.884585152004271 0.541508185877295 0.3 27.1 27 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.801858394975527 0.9084749172374 0.534822899631896 0.296296296296296 27.1 27 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.782007172287508 0.891663626734875 0.530890378311073 0.294117647058824 27.1 27 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.830364393994589 0.929668397052951 0.524040179881253 0.290322580645161 27.1 27 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.836207723496139 0.934931862099911 0.5157220817879 0.285714285714286 27.1 27 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999952461818978 1 0.479169614650871 0.265463917525773 27.1 27 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.948623885583014 1 0.460858030533868 0.25531914893617 27.1 27 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.893246817127301 0.980779491336535 0.451256821564412 0.25 27.1 27 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.969865774974428 1 0.442742541912253 0.245283018867925 27.1 27 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.987642496718811 1 0.432189631920845 0.23943661971831 27.1 27 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.960245345951532 1 0.427506462534706 0.236842105263158 27.1 27 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999997592715995 1 0.419024191452668 0.232142857142857 27.1 27 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999959759413315 1 0.407586806574308 0.225806451612903 27.1 27 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.976308471990501 1 0.382884575872835 0.212121212121212 27.1 27 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999991950686732 1 0.379465963588256 0.210227272727273 27.1 27 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.365249014263722 0.202350965575147 27.1 27 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.986074761326756 1 0.36100545725153 0.2 27.1 27 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.98044144597256 1 0.36100545725153 0.2 27.1 27 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.972406842178698 1 0.36100545725153 0.2 27.1 27 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.988614540136851 1 0.322326301117437 0.178571428571429 27.1 27 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.993800195425495 1 0.318534226986644 0.176470588235294 27.1 27 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.306821998025712 0.16998191681736 27.1 27 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.998944131585971 1 0.300837881042941 0.166666666666667 27.1 27 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.998944131585971 1 0.300837881042941 0.166666666666667 27.1 27 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999994006353 1 0.217271802975458 0.12037037037037 27.1 27 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999975572304 1 0.200558587361961 0.111111111111111 27.1 27 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0203793403287154 0.0112903225806452 27.1 27 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 1.99985814933544e-05 7.46928647376467e-05 1.29806259314456 1 27.3 27 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 7.15463138023532e-07 3.36538642338674e-06 1.29806259314456 1 27.3 27 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 1.64518676821524e-06 7.05150834689845e-06 1.29806259314456 1 27.3 27 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 1.64518676821524e-06 7.05150834689845e-06 1.29806259314456 1 27.3 27 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 4.59791115662803e-05 0.000162353041585154 1.29806259314456 1 27.3 27 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 4.59791115662803e-05 0.000162353041585154 1.29806259314456 1 27.3 27 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000105707383265356 0.00034500368437294 1.29806259314456 1 27.3 27 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000243015197672267 0.00074367876620997 1.29806259314456 1 27.3 27 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000558656573514197 0.00160599657396101 1.29806259314456 1 27.3 27 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.000558656573514197 0.00160599657396101 1.29806259314456 1 27.3 27 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.000558656573514197 0.00160599657396101 1.29806259314456 1 27.3 27 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.000558656573514197 0.00160599657396101 1.29806259314456 1 27.3 27 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000558656573514197 0.00160599657396101 1.29806259314456 1 27.3 27 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00128422098056849 0.00334085275200907 1.29806259314456 1 27.3 27 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00128422098056849 0.00334085275200907 1.29806259314456 1 27.3 27 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00128422098056849 0.00334085275200907 1.29806259314456 1 27.3 27 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00128422098056849 0.00334085275200907 1.29806259314456 1 27.3 27 3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.00295201104696316 0.00699813921272526 1.29806259314456 1 27.3 27 3 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.00295201104696316 0.00699813921272526 1.29806259314456 1 27.3 27 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00295201104696316 0.00699813921272526 1.29806259314456 1 27.3 27 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00295201104696316 0.00699813921272526 1.29806259314456 1 27.3 27 3 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00295201104696316 0.00699813921272526 1.29806259314456 1 27.3 27 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00295201104696316 0.00699813921272526 1.29806259314456 1 27.3 27 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00678546426476664 0.0144546641448547 1.29806259314456 1 27.3 27 3 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00678546426476664 0.0144546641448547 1.29806259314456 1 27.3 27 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00678546426476664 0.0144546641448547 1.29806259314456 1 27.3 27 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00678546426476664 0.0144546641448547 1.29806259314456 1 27.3 27 3 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.00678546426476664 0.0144546641448547 1.29806259314456 1 27.3 27 3 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.00678546426476664 0.0144546641448547 1.29806259314456 1 27.3 27 3 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_199058.2 GRB7 EVENTS IN ERBB2 SIGNALING 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0155964059359368 0.0293567270460821 1.29806259314456 1 27.3 27 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.57398876299786e-12 5.91707819067815e-11 1.26200529889054 0.972222222222222 27.3 27 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 6.77033150493351e-08 3.74870884494957e-07 1.24397665176354 0.958333333333333 27.3 27 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 7.23833396543167e-07 3.36538642338674e-06 1.23625008870911 0.952380952380952 27.3 27 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 7.23833396543167e-07 3.36538642338674e-06 1.23625008870911 0.952380952380952 27.3 27 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 7.23833396543167e-07 3.36538642338674e-06 1.23625008870911 0.952380952380952 27.3 27 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.5881159621527e-06 6.91097557841985e-06 1.23315946348733 0.95 27.3 27 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 1.5881159621527e-06 6.91097557841985e-06 1.23315946348733 0.95 27.3 27 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 1.5881159621527e-06 6.91097557841985e-06 1.23315946348733 0.95 27.3 27 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 3.47617241218013e-06 1.41736198926428e-05 1.22974350929485 0.947368421052632 27.3 27 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 7.58911692820603e-06 2.97501746248958e-05 1.22594800463653 0.944444444444444 27.3 27 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 1.65207648512825e-05 6.31963666219759e-05 1.22170597001841 0.941176470588235 27.3 27 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 1.65207648512825e-05 6.31963666219759e-05 1.22170597001841 0.941176470588235 27.3 27 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 1.09189015055146e-09 9.03348653624843e-09 1.21939213295398 0.939393939393939 27.3 27 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 3.58488282980619e-05 0.000128820410778136 1.21693368107303 0.9375 27.3 27 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 3.58488282980619e-05 0.000128820410778136 1.21693368107303 0.9375 27.3 27 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 3.58488282980619e-05 0.000128820410778136 1.21693368107303 0.9375 27.3 27 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 3.58488282980619e-05 0.000128820410778136 1.21693368107303 0.9375 27.3 27 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.10064362509424e-08 7.60298970150047e-08 1.21152508693492 0.933333333333333 27.3 27 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.10064362509424e-08 7.60298970150047e-08 1.21152508693492 0.933333333333333 27.3 27 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 7.75097299046393e-05 0.000260132890694108 1.21152508693492 0.933333333333333 27.3 27 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 7.75097299046393e-05 0.000260132890694108 1.21152508693492 0.933333333333333 27.3 27 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 7.75097299046393e-05 0.000260132890694108 1.21152508693492 0.933333333333333 27.3 27 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000166905680708463 0.000524388883942857 1.20534383649138 0.928571428571429 27.3 27 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000166905680708463 0.000524388883942857 1.20534383649138 0.928571428571429 27.3 27 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000166905680708463 0.000524388883942857 1.20534383649138 0.928571428571429 27.3 27 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000166905680708463 0.000524388883942857 1.20534383649138 0.928571428571429 27.3 27 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 1.0874832565866e-07 5.88398735407885e-07 1.20190980846719 0.925925925925926 27.3 27 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000357745472441393 0.00106723649325807 1.19821162444113 0.923076923076923 27.3 27 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000357745472441393 0.00106723649325807 1.19821162444113 0.923076923076923 27.3 27 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000357745472441393 0.00106723649325807 1.19821162444113 0.923076923076923 27.3 27 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000357745472441393 0.00106723649325807 1.19821162444113 0.923076923076923 27.3 27 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000357745472441393 0.00106723649325807 1.19821162444113 0.923076923076923 27.3 27 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 3.57898190501721e-10 3.22334889293639e-09 1.19558396736999 0.921052631578947 27.3 27 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 4.94111845707537e-07 2.44139290431189e-06 1.194217585693 0.92 27.3 27 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 4.94111845707537e-07 2.44139290431189e-06 1.194217585693 0.92 27.3 27 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 4.94111845707537e-07 2.44139290431189e-06 1.194217585693 0.92 27.3 27 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 7.59877090568916e-10 6.46007463914077e-09 1.19281427478149 0.918918918918919 27.3 27 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.59111159802773e-12 3.47844509810704e-11 1.18989071038251 0.916666666666667 27.3 27 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00076271837195519 0.00208720816017738 1.18989071038251 0.916666666666667 27.3 27 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.21682960036071e-06 9.30545286523094e-06 1.18518758504503 0.91304347826087 27.3 27 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 7.17162876556661e-09 5.36382041523263e-08 1.18352765845533 0.911764705882353 27.3 27 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 4.67015783922387e-06 1.88261603547183e-05 1.18005690285869 0.909090909090909 27.3 27 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00161609334174138 0.00401343948568583 1.18005690285869 0.909090909090909 27.3 27 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.07038632161492e-10 1.05045499010899e-09 1.17731258447995 0.906976744186046 27.3 27 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 9.79880033544328e-06 3.80975215227754e-05 1.17443758427365 0.904761904761905 27.3 27 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 6.60814492517264e-08 3.67319930801589e-07 1.17244363251767 0.903225806451613 27.3 27 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.67048384108564e-10 4.10252994189189e-09 1.17142234015485 0.902439024390244 27.3 27 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.67048384108564e-10 4.10252994189189e-09 1.17142234015485 0.902439024390244 27.3 27 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.0468680462427e-05 7.62485138691981e-05 1.1682563338301 0.9 27.3 27 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00339942895609157 0.00780223774922307 1.1682563338301 0.9 27.3 27 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00339942895609157 0.00780223774922307 1.1682563338301 0.9 27.3 27 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00339942895609157 0.00780223774922307 1.1682563338301 0.9 27.3 27 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00339942895609157 0.00780223774922307 1.1682563338301 0.9 27.3 27 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00339942895609157 0.00780223774922307 1.1682563338301 0.9 27.3 27 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 4.25491453144262e-05 0.000150991106689348 1.16142442544513 0.894736842105263 27.3 27 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 5.91609763180982e-07 2.90296790691909e-06 1.15898445816479 0.892857142857143 27.3 27 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.77398377713091e-08 1.16869394206356e-07 1.1538334161285 0.888888888888889 27.3 27 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 8.7973948235895e-05 0.000289784556341848 1.1538334161285 0.888888888888889 27.3 27 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 8.7973948235895e-05 0.000289784556341848 1.1538334161285 0.888888888888889 27.3 27 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 8.7973948235895e-05 0.000289784556341848 1.1538334161285 0.888888888888889 27.3 27 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 8.7973948235895e-05 0.000289784556341848 1.1538334161285 0.888888888888889 27.3 27 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.00708873623700283 0.0148560701991974 1.1538334161285 0.888888888888889 27.3 27 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 2.50252592070757e-06 1.04125566817745e-05 1.14828614008942 0.884615384615385 27.3 27 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.3028954786663e-13 7.54602026614214e-12 1.1466219572777 0.883333333333333 27.3 27 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.3028954786663e-13 7.54602026614214e-12 1.1466219572777 0.883333333333333 27.3 27 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.3028954786663e-13 7.54602026614214e-12 1.1466219572777 0.883333333333333 27.3 27 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.3028954786663e-13 7.54602026614214e-12 1.1466219572777 0.883333333333333 27.3 27 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.3028954786663e-13 7.54602026614214e-12 1.1466219572777 0.883333333333333 27.3 27 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.3028954786663e-13 7.54602026614214e-12 1.1466219572777 0.883333333333333 27.3 27 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.3028954786663e-13 7.54602026614214e-12 1.1466219572777 0.883333333333333 27.3 27 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 7.43786986178033e-08 4.08652077734108e-07 1.14534934689226 0.882352941176471 27.3 27 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 3.41148156157377e-14 6.22376700271727e-13 1.14307004470939 0.880597014925373 27.3 27 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 5.11305545007836e-06 2.04378592850042e-05 1.14229508196721 0.88 27.3 27 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 1.51489688606012e-07 8.04055047251689e-07 1.1407216727634 0.878787878787879 27.3 27 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.42501270870145e-10 1.37945107787902e-09 1.13911615316768 0.877551020408163 27.3 27 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.86968141898113e-16 7.56214196150028e-15 1.13580476900149 0.875 27.3 27 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 9.33728190934837e-09 6.67686038040338e-08 1.13580476900149 0.875 27.3 27 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 3.07360233931034e-07 1.55648972556534e-06 1.13580476900149 0.875 27.3 27 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 1.03959412552615e-05 4.01995228430357e-05 1.13580476900149 0.875 27.3 27 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000369136041150681 0.00108979374804444 1.13580476900149 0.875 27.3 27 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000369136041150681 0.00108979374804444 1.13580476900149 0.875 27.3 27 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.000369136041150681 0.00108979374804444 1.13580476900149 0.875 27.3 27 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000369136041150681 0.00108979374804444 1.13580476900149 0.875 27.3 27 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000369136041150681 0.00108979374804444 1.13580476900149 0.875 27.3 27 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0146265415117259 0.0285117377687478 1.13580476900149 0.875 27.3 27 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 5.82597370983532e-10 5.02446096308828e-09 1.13235247487079 0.872340425531915 27.3 27 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 6.21063590353577e-07 3.02662153792171e-06 1.13057064564204 0.870967741935484 27.3 27 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 2.10256794316449e-05 7.8118908175537e-05 1.12875008099527 0.869565217391304 27.3 27 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 9.45017584075191e-15 1.94892756831739e-13 1.12498758072529 0.866666666666667 27.3 27 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 9.45017584075191e-15 1.94892756831739e-13 1.12498758072529 0.866666666666667 27.3 27 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 9.45017584075191e-15 1.94892756831739e-13 1.12498758072529 0.866666666666667 27.3 27 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 9.45017584075191e-15 1.94892756831739e-13 1.12498758072529 0.866666666666667 27.3 27 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 9.45017584075191e-15 1.94892756831739e-13 1.12498758072529 0.866666666666667 27.3 27 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 9.45017584075191e-15 1.94892756831739e-13 1.12498758072529 0.866666666666667 27.3 27 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.35395460734012e-09 1.87132815991341e-08 1.12498758072529 0.866666666666667 27.3 27 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000747979360933319 0.00208700907962375 1.12498758072529 0.866666666666667 27.3 27 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000747979360933319 0.00208700907962375 1.12498758072529 0.866666666666667 27.3 27 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000747979360933319 0.00208700907962375 1.12498758072529 0.866666666666667 27.3 27 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000747979360933319 0.00208700907962375 1.12498758072529 0.866666666666667 27.3 27 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000747979360933319 0.00208700907962375 1.12498758072529 0.866666666666667 27.3 27 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.96080516319327e-13 4.62991840354288e-12 1.12369597615499 0.865671641791045 27.3 27 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.96080516319327e-13 4.62991840354288e-12 1.12369597615499 0.865671641791045 27.3 27 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.47516978347322e-10 1.40883664555866e-09 1.12332339791356 0.865384615384615 27.3 27 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.47516978347322e-10 1.40883664555866e-09 1.12332339791356 0.865384615384615 27.3 27 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 7.61006940871898e-08 4.16504952638735e-07 1.12264872920611 0.864864864864865 27.3 27 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 9.3144130192058e-12 1.14262152813188e-10 1.12205410593852 0.864406779661017 27.3 27 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 9.3144130192058e-12 1.14262152813188e-10 1.12205410593852 0.864406779661017 27.3 27 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.70920070589442e-09 3.62226627269609e-08 1.12105405771576 0.863636363636364 27.3 27 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 4.22802028114992e-05 0.000150411821501908 1.12105405771576 0.863636363636364 27.3 27 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 4.22802028114992e-05 0.000150411821501908 1.12105405771576 0.863636363636364 27.3 27 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 2.50210055768273e-06 1.04125566817745e-05 1.11901947684876 0.862068965517241 27.3 27 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.51996351167045e-07 8.04055047251689e-07 1.11777612187448 0.861111111111111 27.3 27 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.51996351167045e-07 8.04055047251689e-07 1.11777612187448 0.861111111111111 27.3 27 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.51996351167045e-07 8.04055047251689e-07 1.11777612187448 0.861111111111111 27.3 27 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.27455245486514e-18 5.18196612363743e-17 1.11633383010432 0.86 27.3 27 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 6.11806672864362e-16 1.52736999208068e-14 1.1148066976418 0.858823529411765 27.3 27 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 5.01456898441137e-18 1.82967478585061e-16 1.11262507983819 0.857142857142857 27.3 27 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 8.4487961224329e-05 0.000280902730893038 1.11262507983819 0.857142857142857 27.3 27 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 8.4487961224329e-05 0.000280902730893038 1.11262507983819 0.857142857142857 27.3 27 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 8.4487961224329e-05 0.000280902730893038 1.11262507983819 0.857142857142857 27.3 27 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 8.4487961224329e-05 0.000280902730893038 1.11262507983819 0.857142857142857 27.3 27 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 4.98555710816885e-06 1.99843599011951e-05 1.11262507983819 0.857142857142857 27.3 27 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00150278422283896 0.00379833383499084 1.11262507983819 0.857142857142857 27.3 27 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00150278422283896 0.00379833383499084 1.11262507983819 0.857142857142857 27.3 27 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00150278422283896 0.00379833383499084 1.11262507983819 0.857142857142857 27.3 27 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00150278422283896 0.00379833383499084 1.11262507983819 0.857142857142857 27.3 27 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00150278422283896 0.00379833383499084 1.11262507983819 0.857142857142857 27.3 27 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00150278422283896 0.00379833383499084 1.11262507983819 0.857142857142857 27.3 27 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0297861835715875 0.0524094714900788 1.11262507983819 0.857142857142857 27.3 27 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.69258512919368e-08 2.22650366052653e-07 1.10810221365999 0.853658536585366 27.3 27 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.69258512919368e-08 2.22650366052653e-07 1.10810221365999 0.853658536585366 27.3 27 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 9.88097993595977e-06 3.83123554465143e-05 1.10575702378981 0.851851851851852 27.3 27 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.5458853716464e-09 3.51564939339828e-08 1.10473412182516 0.851063829787234 27.3 27 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000167671779475756 0.000524388883942857 1.10335320417288 0.85 27.3 27 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000167671779475756 0.000524388883942857 1.10335320417288 0.85 27.3 27 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000167671779475756 0.000524388883942857 1.10335320417288 0.85 27.3 27 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000167671779475756 0.000524388883942857 1.10335320417288 0.85 27.3 27 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 1.18023528775116e-06 5.19961242869936e-06 1.10138644266811 0.848484848484849 27.3 27 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 8.93425913639994e-09 6.44858059806868e-08 1.10053132897039 0.847826086956522 27.3 27 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 8.93425913639994e-09 6.44858059806868e-08 1.10053132897039 0.847826086956522 27.3 27 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 1.94709678616178e-05 7.29136507028477e-05 1.09836065573771 0.846153846153846 27.3 27 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.94709678616178e-05 7.29136507028477e-05 1.09836065573771 0.846153846153846 27.3 27 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 1.94709678616178e-05 7.29136507028477e-05 1.09836065573771 0.846153846153846 27.3 27 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 1.94709678616178e-05 7.29136507028477e-05 1.09836065573771 0.846153846153846 27.3 27 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00299006931928107 0.00699813921272526 1.09836065573771 0.846153846153846 27.3 27 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00299006931928107 0.00699813921272526 1.09836065573771 0.846153846153846 27.3 27 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00299006931928107 0.00699813921272526 1.09836065573771 0.846153846153846 27.3 27 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00299006931928107 0.00699813921272526 1.09836065573771 0.846153846153846 27.3 27 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00299006931928107 0.00699813921272526 1.09836065573771 0.846153846153846 27.3 27 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.74948223837607e-08 1.15791312800425e-07 1.09614174532207 0.844444444444444 27.3 27 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000330239563817061 0.000995616312101012 1.09310534159542 0.842105263157895 27.3 27 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000330239563817061 0.000995616312101012 1.09310534159542 0.842105263157895 27.3 27 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000330239563817061 0.000995616312101012 1.09310534159542 0.842105263157895 27.3 27 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.32979121095434e-11 3.43354557477393e-10 1.09202091169304 0.841269841269841 27.3 27 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 3.81310917324728e-05 0.000136333023958062 1.09037257824143 0.84 27.3 27 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 6.55190690707236e-14 1.13699555228829e-12 1.08973155967691 0.839506172839506 27.3 27 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 6.55190690707236e-14 1.13699555228829e-12 1.08973155967691 0.839506172839506 27.3 27 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.45533435037342e-13 3.9257761579566e-12 1.08445735629799 0.835443037974684 27.3 27 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.45533435037342e-13 3.9257761579566e-12 1.08445735629799 0.835443037974684 27.3 27 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.45533435037342e-13 3.9257761579566e-12 1.08445735629799 0.835443037974684 27.3 27 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.08776413086206e-14 5.70634851716457e-13 1.08426404839134 0.835294117647059 27.3 27 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.08776413086206e-14 5.70634851716457e-13 1.08426404839134 0.835294117647059 27.3 27 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.08776413086206e-14 5.70634851716457e-13 1.08426404839134 0.835294117647059 27.3 27 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.08776413086206e-14 5.70634851716457e-13 1.08426404839134 0.835294117647059 27.3 27 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.05400685936671e-06 4.68703675274633e-06 1.08171882762047 0.833333333333333 27.3 27 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 7.41743703135621e-05 0.000250712895382895 1.08171882762047 0.833333333333333 27.3 27 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 7.41743703135621e-05 0.000250712895382895 1.08171882762047 0.833333333333333 27.3 27 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 7.41743703135621e-05 0.000250712895382895 1.08171882762047 0.833333333333333 27.3 27 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 7.41743703135621e-05 0.000250712895382895 1.08171882762047 0.833333333333333 27.3 27 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 7.41743703135621e-05 0.000250712895382895 1.08171882762047 0.833333333333333 27.3 27 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 7.41743703135621e-05 0.000250712895382895 1.08171882762047 0.833333333333333 27.3 27 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000644986083713961 0.00183563039424993 1.08171882762047 0.833333333333333 27.3 27 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000644986083713961 0.00183563039424993 1.08171882762047 0.833333333333333 27.3 27 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000644986083713961 0.00183563039424993 1.08171882762047 0.833333333333333 27.3 27 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000644986083713961 0.00183563039424993 1.08171882762047 0.833333333333333 27.3 27 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00588296819067234 0.012859391298505 1.08171882762047 0.833333333333333 27.3 27 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00588296819067234 0.012859391298505 1.08171882762047 0.833333333333333 27.3 27 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00588296819067234 0.012859391298505 1.08171882762047 0.833333333333333 27.3 27 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00588296819067234 0.012859391298505 1.08171882762047 0.833333333333333 27.3 27 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00588296819067234 0.012859391298505 1.08171882762047 0.833333333333333 27.3 27 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00588296819067234 0.012859391298505 1.08171882762047 0.833333333333333 27.3 27 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00588296819067234 0.012859391298505 1.08171882762047 0.833333333333333 27.3 27 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00588296819067234 0.012859391298505 1.08171882762047 0.833333333333333 27.3 27 3 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.0596511142917877 0.0972319995844375 1.08171882762047 0.833333333333333 27.3 27 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 7.50050723412074e-15 1.72148738615384e-13 1.08171882762047 0.833333333333333 27.3 27 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 2.47098428683956e-07 1.27862205097189e-06 1.07644215041256 0.829268292682927 27.3 27 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.47098428683956e-07 1.27862205097189e-06 1.07644215041256 0.829268292682927 27.3 27 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.03134307144576e-06 8.6029797341289e-06 1.07553757717692 0.828571428571429 27.3 27 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.03134307144576e-06 8.6029797341289e-06 1.07553757717692 0.828571428571429 27.3 27 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.03134307144576e-06 8.6029797341289e-06 1.07553757717692 0.828571428571429 27.3 27 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.11373586693938e-10 1.08551105387311e-09 1.07495808494784 0.828125 27.3 27 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 6.69743678136994e-15 1.56236926883433e-13 1.07473999647453 0.827956989247312 27.3 27 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 1.69061485505023e-05 6.41531983663059e-05 1.07425869777481 0.827586206896552 27.3 27 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 1.69061485505023e-05 6.41531983663059e-05 1.07425869777481 0.827586206896552 27.3 27 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.69061485505023e-05 6.41531983663059e-05 1.07425869777481 0.827586206896552 27.3 27 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.66700436458024e-11 2.77018044583773e-10 1.07231257694551 0.826086956521739 27.3 27 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 5.81574978087246e-08 3.27107191232471e-07 1.07231257694551 0.826086956521739 27.3 27 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000143239188865808 0.000457016515148083 1.07231257694551 0.826086956521739 27.3 27 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000143239188865808 0.000457016515148083 1.07231257694551 0.826086956521739 27.3 27 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.13020578126008e-10 1.9556663398278e-09 1.07141674354789 0.825396825396825 27.3 27 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.19796453084024e-17 4.05881792234681e-16 1.07033231364551 0.824561403508772 27.3 27 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.06042133008452e-40 1.07799744408878e-37 1.06899272376611 0.823529411764706 27.3 27 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 3.89391062141425e-06 1.57415761769105e-05 1.06899272376611 0.823529411764706 27.3 27 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 3.89391062141425e-06 1.57415761769105e-05 1.06899272376611 0.823529411764706 27.3 27 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00124799414715896 0.00328261676785064 1.06899272376611 0.823529411764706 27.3 27 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00124799414715896 0.00328261676785064 1.06899272376611 0.823529411764706 27.3 27 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00124799414715896 0.00328261676785064 1.06899272376611 0.823529411764706 27.3 27 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.37330040220051e-08 9.23604324521822e-08 1.06899272376611 0.823529411764706 27.3 27 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.37330040220051e-08 9.23604324521822e-08 1.06899272376611 0.823529411764706 27.3 27 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.79771317546157e-16 4.8376467060455e-15 1.06756549716562 0.822429906542056 27.3 27 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 3.23999249437977e-05 0.000117615033660776 1.0662657015116 0.821428571428571 27.3 27 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 3.23999249437977e-05 0.000117615033660776 1.0662657015116 0.821428571428571 27.3 27 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 3.23999249437977e-05 0.000117615033660776 1.0662657015116 0.821428571428571 27.3 27 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 2.61366398567603e-08 1.67533506829594e-07 1.06441132637854 0.82 27.3 27 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 2.61366398567603e-08 1.67533506829594e-07 1.06441132637854 0.82 27.3 27 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 7.7175874114823e-10 6.46007463914077e-09 1.06398573208571 0.819672131147541 27.3 27 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 7.7175874114823e-10 6.46007463914077e-09 1.06398573208571 0.819672131147541 27.3 27 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 7.7175874114823e-10 6.46007463914077e-09 1.06398573208571 0.819672131147541 27.3 27 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 2.30969368550944e-11 2.69401156924585e-10 1.06369018049346 0.819444444444444 27.3 27 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.77181801353672e-23 1.32699843855935e-21 1.06278874813711 0.81875 27.3 27 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 5.09385716272426e-15 1.20809312375944e-13 1.06205121257282 0.818181818181818 27.3 27 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 7.42178063781402e-06 2.91745686398048e-05 1.06205121257282 0.818181818181818 27.3 27 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000274422874082061 0.000836196466421354 1.06205121257282 0.818181818181818 27.3 27 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000274422874082061 0.000836196466421354 1.06205121257282 0.818181818181818 27.3 27 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0114244392206674 0.0227688753655597 1.06205121257282 0.818181818181818 27.3 27 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 4.37167501224744e-11 4.3809109453719e-10 1.06038916059696 0.816901408450704 27.3 27 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 6.16669147345136e-05 0.000213508563667185 1.05768063145112 0.814814814814815 27.3 27 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.16669147345136e-05 0.000213508563667185 1.05768063145112 0.814814814814815 27.3 27 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 6.16669147345136e-05 0.000213508563667185 1.05768063145112 0.814814814814815 27.3 27 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 6.16669147345136e-05 0.000213508563667185 1.05768063145112 0.814814814814815 27.3 27 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 6.16669147345136e-05 0.000213508563667185 1.05768063145112 0.814814814814815 27.3 27 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.17790447286683e-29 1.2893523576073e-27 1.05699382584628 0.814285714285714 27.3 27 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 5.15609142048306e-26 4.31595181843964e-24 1.0568924938718 0.814207650273224 27.3 27 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 9.85805812597046e-19 4.1258872686047e-17 1.05656257581534 0.813953488372093 27.3 27 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 5.95543552629578e-13 8.39067797417713e-12 1.05656257581534 0.813953488372093 27.3 27 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 3.99432527994758e-07 2.00138199766388e-06 1.05656257581534 0.813953488372093 27.3 27 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00238963374665809 0.00576347257880418 1.05467585692996 0.8125 27.3 27 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00238963374665809 0.00576347257880418 1.05467585692996 0.8125 27.3 27 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00238963374665809 0.00576347257880418 1.05467585692996 0.8125 27.3 27 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00238963374665809 0.00576347257880418 1.05467585692996 0.8125 27.3 27 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00238963374665809 0.00576347257880418 1.05467585692996 0.8125 27.3 27 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.83361467620867e-58 1.36380842106123e-55 1.05429497001882 0.812206572769953 27.3 27 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.55185531181995e-10 1.43395461605181e-09 1.05350007559559 0.811594202898551 27.3 27 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 3.23921948773993e-06 1.3283600377677e-05 1.05248318363072 0.810810810810811 27.3 27 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 3.23921948773993e-06 1.3283600377677e-05 1.05248318363072 0.810810810810811 27.3 27 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 7.52068083371035e-07 3.36538642338674e-06 1.05081257540274 0.80952380952381 27.3 27 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 7.52068083371035e-07 3.36538642338674e-06 1.05081257540274 0.80952380952381 27.3 27 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000521203007044315 0.00152922036912178 1.05081257540274 0.80952380952381 27.3 27 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000521203007044315 0.00152922036912178 1.05081257540274 0.80952380952381 27.3 27 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.75661589989585e-07 9.22385396882581e-07 1.0494974157339 0.808510638297872 27.3 27 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000116503611990064 0.000376783272413319 1.04843517138599 0.807692307692308 27.3 27 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.000116503611990064 0.000376783272413319 1.04843517138599 0.807692307692308 27.3 27 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000116503611990064 0.000376783272413319 1.04843517138599 0.807692307692308 27.3 27 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.92814591491287e-18 1.09651358866342e-16 1.04843517138599 0.807692307692308 27.3 27 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 7.32082729691807e-12 9.38516868785082e-11 1.04478208716513 0.804878048780488 27.3 27 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.23862423891292e-34 1.60232935633917e-32 1.04441817839218 0.804597701149425 27.3 27 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 7.6991546779256e-08 4.19766172670043e-07 1.04354051605739 0.803921568627451 27.3 27 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.81184318684951e-08 1.18268479581965e-07 1.04308601234831 0.803571428571429 27.3 27 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.81184318684951e-08 1.18268479581965e-07 1.04308601234831 0.803571428571429 27.3 27 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.89204910375441e-17 6.11905880600575e-16 1.04253846063579 0.803149606299213 27.3 27 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.74284333410131e-29 1.7714757603044e-27 1.04194261960931 0.802690582959641 27.3 27 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.08799106313831e-67 5.16070427615273e-65 1.04141143404373 0.802281368821293 27.3 27 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 3.62134719997869e-38 5.72575229507742e-36 1.04110822317055 0.802047781569966 27.3 27 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.73341231963302e-22 1.17459320516085e-20 1.03845007451565 0.8 27.3 27 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 4.45948262929805e-10 3.96615236343195e-09 1.03845007451565 0.8 27.3 27 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.87989915055871e-09 1.50286319732867e-08 1.03845007451565 0.8 27.3 27 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 7.94369825709824e-09 5.79686288197476e-08 1.03845007451565 0.8 27.3 27 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 7.94369825709824e-09 5.79686288197476e-08 1.03845007451565 0.8 27.3 27 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.36630716698341e-08 2.0647651287144e-07 1.03845007451565 0.8 27.3 27 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.36630716698341e-08 2.0647651287144e-07 1.03845007451565 0.8 27.3 27 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.36630716698341e-08 2.0647651287144e-07 1.03845007451565 0.8 27.3 27 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 3.36630716698341e-08 2.0647651287144e-07 1.03845007451565 0.8 27.3 27 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.36630716698341e-08 2.0647651287144e-07 1.03845007451565 0.8 27.3 27 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 3.36630716698341e-08 2.0647651287144e-07 1.03845007451565 0.8 27.3 27 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 2.62454057773612e-06 1.08567477968561e-05 1.03845007451565 0.8 27.3 27 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 2.62454057773612e-06 1.08567477968561e-05 1.03845007451565 0.8 27.3 27 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000218347484637918 0.00067545319704295 1.03845007451565 0.8 27.3 27 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000218347484637918 0.00067545319704295 1.03845007451565 0.8 27.3 27 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.000980510701182289 0.0026276209562757 1.03845007451565 0.8 27.3 27 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.000980510701182289 0.0026276209562757 1.03845007451565 0.8 27.3 27 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000980510701182289 0.0026276209562757 1.03845007451565 0.8 27.3 27 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00452200367046154 0.010023070440914 1.03845007451565 0.8 27.3 27 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00452200367046154 0.010023070440914 1.03845007451565 0.8 27.3 27 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00452200367046154 0.010023070440914 1.03845007451565 0.8 27.3 27 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00452200367046154 0.010023070440914 1.03845007451565 0.8 27.3 27 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00452200367046154 0.010023070440914 1.03845007451565 0.8 27.3 27 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0218459653606479 0.0398038523792599 1.03845007451565 0.8 27.3 27 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.20563176102481e-22 1.90067249830763e-20 1.03691390576636 0.798816568047337 27.3 27 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.66391254585085e-18 6.39931771012367e-17 1.03658235855429 0.798561151079137 27.3 27 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.66391254585085e-18 6.39931771012367e-17 1.03658235855429 0.798561151079137 27.3 27 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.00818363117173e-16 1.29575369221043e-14 1.03626845671204 0.798319327731092 27.3 27 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 8.70979427902625e-15 1.94892756831739e-13 1.0360683082897 0.798165137614679 27.3 27 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.51840686134179e-13 2.54199172198749e-12 1.03582772584263 0.797979797979798 27.3 27 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.46226568459033e-21 1.40152162766881e-19 1.03526464483922 0.797546012269939 27.3 27 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.469238833874e-08 9.81561906386246e-08 1.0340498623355 0.796610169491525 27.3 27 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 6.22781354883845e-08 3.47536418823416e-07 1.03364243528178 0.796296296296296 27.3 27 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 6.22781354883845e-08 3.47536418823416e-07 1.03364243528178 0.796296296296296 27.3 27 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 7.85260065175963e-20 3.72475024248465e-18 1.03332614322692 0.796052631578947 27.3 27 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.13181779722799e-06 5.00179107284294e-06 1.03254979000135 0.795454545454545 27.3 27 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.05015164263919e-11 2.4110461053517e-10 1.03219435117519 0.795180722891566 27.3 27 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.6107600687738e-10 3.23151671563844e-09 1.03133740277239 0.794520547945205 27.3 27 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 6.40410935704953e-09 4.84736575270291e-08 1.03020840725759 0.793650793650794 27.3 27 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.70640100394321e-08 1.70407461442973e-07 1.02949791870086 0.793103448275862 27.3 27 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.70640100394321e-08 1.70407461442973e-07 1.02949791870086 0.793103448275862 27.3 27 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.70640100394321e-08 1.70407461442973e-07 1.02949791870086 0.793103448275862 27.3 27 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.70640100394321e-08 1.70407461442973e-07 1.02949791870086 0.793103448275862 27.3 27 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 9.17927344514302e-05 0.000301665268185647 1.02949791870086 0.793103448275862 27.3 27 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 8.99698842046793e-12 1.12304513353736e-10 1.02949791870086 0.793103448275862 27.3 27 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 8.99698842046793e-12 1.12304513353736e-10 1.02949791870086 0.793103448275862 27.3 27 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.8166938227818e-20 1.38212252062707e-18 1.02865337569946 0.792452830188679 27.3 27 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.14707766496807e-07 6.15959063113043e-07 1.02865337569946 0.792452830188679 27.3 27 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.21205633924935e-32 3.80896347562651e-30 1.02846497764531 0.792307692307692 27.3 27 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 6.6307167841105e-10 5.68404215890918e-09 1.02763288623944 0.791666666666667 27.3 27 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 4.87897402618748e-07 2.43606317167185e-06 1.02763288623944 0.791666666666667 27.3 27 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000405685499364344 0.00119521835527011 1.02763288623944 0.791666666666667 27.3 27 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.17170777213356e-22 1.90067249830763e-20 1.02671617536858 0.790960451977401 27.3 27 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.38295315246596e-14 4.64512648761515e-13 1.02664950548706 0.790909090909091 27.3 27 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 2.08424684812588e-06 8.80084054861462e-06 1.02637507364919 0.790697674418605 27.3 27 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.17518756016572e-08 8.03986489478758e-08 1.02588817845296 0.790322580645161 27.3 27 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 9.43417787252929e-20 4.33059197180941e-18 1.02522141114602 0.789808917197452 27.3 27 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 6.38735411695303e-17 1.85493977722942e-15 1.02478625774571 0.789473684210526 27.3 27 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00182528553332733 0.00449373929744774 1.02478625774571 0.789473684210526 27.3 27 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.32051353470311e-27 2.06380672492658e-25 1.024479894141 0.789237668161435 27.3 27 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.81360925864772e-13 3.00089066866943e-12 1.02347242921013 0.788461538461538 27.3 27 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 2.10304032310401e-07 1.10023028668272e-06 1.02347242921013 0.788461538461538 27.3 27 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 5.48854759739061e-11 5.42375224381031e-10 1.01990632318501 0.785714285714286 27.3 27 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 5.48854759739061e-11 5.42375224381031e-10 1.01990632318501 0.785714285714286 27.3 27 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 3.81655860597429e-06 1.55170368465755e-05 1.01990632318501 0.785714285714286 27.3 27 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.24031628084643e-17 6.64160430759265e-16 1.01990632318501 0.785714285714286 27.3 27 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000168979210633804 0.000527318896341894 1.01990632318501 0.785714285714286 27.3 27 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00844344800623544 0.0174637013268503 1.01990632318501 0.785714285714286 27.3 27 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00844344800623544 0.0174637013268503 1.01990632318501 0.785714285714286 27.3 27 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00844344800623544 0.0174637013268503 1.01990632318501 0.785714285714286 27.3 27 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00844344800623544 0.0174637013268503 1.01990632318501 0.785714285714286 27.3 27 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.29377056736323e-10 2.09233045984479e-09 1.0187326680375 0.784810126582278 27.3 27 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 3.8372254952321e-07 1.92946002816794e-06 1.01808830834867 0.784313725490196 27.3 27 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.62947640962102e-06 7.02649979057793e-06 1.01587507289574 0.782608695652174 27.3 27 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.62947640962102e-06 7.02649979057793e-06 1.01587507289574 0.782608695652174 27.3 27 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.62947640962102e-06 7.02649979057793e-06 1.01587507289574 0.782608695652174 27.3 27 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.000746684140860574 0.00208700907962375 1.01587507289574 0.782608695652174 27.3 27 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000746684140860574 0.00208700907962375 1.01587507289574 0.782608695652174 27.3 27 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.14202225111296e-13 1.93464007539731e-12 1.01484893645847 0.781818181818182 27.3 27 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.68606103879141e-08 1.12115180289728e-07 1.01411140089419 0.78125 27.3 27 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 7.07664441439512e-05 0.000243827239750224 1.01411140089419 0.78125 27.3 27 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.73893125824973e-09 1.3980221358697e-08 1.01355572341425 0.780821917808219 27.3 27 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.73893125824973e-09 1.3980221358697e-08 1.01355572341425 0.780821917808219 27.3 27 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.28323004113129e-15 5.50684126869461e-14 1.01187556473474 0.779527559055118 27.3 27 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.04943795166039e-16 2.92813765727987e-15 1.01063444751969 0.778571428571429 27.3 27 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 3.13961176386593e-09 2.46832460772443e-08 1.00960423911244 0.777777777777778 27.3 27 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 3.13961176386593e-09 2.46832460772443e-08 1.00960423911244 0.777777777777778 27.3 27 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.98211475026282e-07 1.52098540846738e-06 1.00960423911244 0.777777777777778 27.3 27 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000308432052384488 0.000937817971245996 1.00960423911244 0.777777777777778 27.3 27 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00335852236921646 0.00777102005104883 1.00960423911244 0.777777777777778 27.3 27 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00335852236921646 0.00777102005104883 1.00960423911244 0.777777777777778 27.3 27 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00335852236921646 0.00777102005104883 1.00960423911244 0.777777777777778 27.3 27 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00335852236921646 0.00777102005104883 1.00960423911244 0.777777777777778 27.3 27 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0410088599732565 0.0688968214190602 1.00960423911244 0.777777777777778 27.3 27 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0410088599732565 0.0688968214190602 1.00960423911244 0.777777777777778 27.3 27 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0410088599732565 0.0688968214190602 1.00960423911244 0.777777777777778 27.3 27 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0410088599732565 0.0688968214190602 1.00960423911244 0.777777777777778 27.3 27 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0410088599732565 0.0688968214190602 1.00960423911244 0.777777777777778 27.3 27 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0410088599732565 0.0688968214190602 1.00960423911244 0.777777777777778 27.3 27 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0410088599732565 0.0688968214190602 1.00960423911244 0.777777777777778 27.3 27 3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0410088599732565 0.0688968214190602 1.00960423911244 0.777777777777778 27.3 27 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.35547851935965e-09 1.10853214543033e-08 1.00770648678328 0.776315789473684 27.3 27 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 4.46643985959845e-21 2.35397922970689e-19 1.00723982637447 0.775956284153005 27.3 27 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 6.68411442480971e-13 9.32499492794531e-12 1.00690836664485 0.775700934579439 27.3 27 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.83275265417534e-41 4.34667837815252e-39 1.00651912302653 0.775401069518717 27.3 27 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 5.64719209471999e-09 4.29730179186447e-08 1.00554144539367 0.774647887323944 27.3 27 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 5.48265807812265e-08 3.10829579488786e-07 1.00495168501514 0.774193548387097 27.3 27 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 5.48265807812265e-08 3.10829579488786e-07 1.00495168501514 0.774193548387097 27.3 27 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 5.36924607173523e-07 2.64374988238036e-06 1.004161628659 0.773584905660377 27.3 27 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.32250562117867e-06 2.11562164774784e-05 1.00304836742989 0.772727272727273 27.3 27 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.32250562117867e-06 2.11562164774784e-05 1.00304836742989 0.772727272727273 27.3 27 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00136025545911598 0.00350025952680297 1.00304836742989 0.772727272727273 27.3 27 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00136025545911598 0.00350025952680297 1.00304836742989 0.772727272727273 27.3 27 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 5.37164865453344e-05 0.000188272316142884 1.00136257185438 0.771428571428571 27.3 27 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 2.26000503408496e-06 9.45878577500853e-06 1.00058991554893 0.770833333333333 27.3 27 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.35191123562148e-09 3.38402715207069e-08 0.999859024449188 0.77027027027027 27.3 27 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.35191123562148e-09 3.38402715207069e-08 0.999859024449188 0.77027027027027 27.3 27 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 8.83271044473223e-12 1.12222740739767e-10 0.999508196721311 0.77 27.3 27 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000557827060130766 0.00160599657396101 0.998509687034277 0.769230769230769 27.3 27 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.000557827060130766 0.00160599657396101 0.998509687034277 0.769230769230769 27.3 27 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000557827060130766 0.00160599657396101 0.998509687034277 0.769230769230769 27.3 27 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000557827060130766 0.00160599657396101 0.998509687034277 0.769230769230769 27.3 27 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0155259644286432 0.0293567270460821 0.998509687034277 0.769230769230769 27.3 27 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0155259644286432 0.0293567270460821 0.998509687034277 0.769230769230769 27.3 27 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0155259644286432 0.0293567270460821 0.998509687034277 0.769230769230769 27.3 27 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0155259644286432 0.0293567270460821 0.998509687034277 0.769230769230769 27.3 27 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0155259644286432 0.0293567270460821 0.998509687034277 0.769230769230769 27.3 27 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 7.28236285353721e-18 2.59070058514586e-16 0.997885618479881 0.76875 27.3 27 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.6530040340245e-12 2.26175455809313e-11 0.997585141027764 0.768518518518518 27.3 27 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.000230852988213755 0.000709511451896702 0.99518132141083 0.766666666666667 27.3 27 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.26960390272521e-12 1.75402558599804e-11 0.99401189565124 0.765765765765766 27.3 27 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 9.62036450757284e-05 0.000315432688808206 0.992636100639958 0.764705882352941 27.3 27 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00609996244503025 0.0131718460687072 0.992636100639958 0.764705882352941 27.3 27 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00609996244503025 0.0131718460687072 0.992636100639958 0.764705882352941 27.3 27 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.00609996244503025 0.0131718460687072 0.992636100639958 0.764705882352941 27.3 27 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00609996244503025 0.0131718460687072 0.992636100639958 0.764705882352941 27.3 27 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00609996244503025 0.0131718460687072 0.992636100639958 0.764705882352941 27.3 27 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00609996244503025 0.0131718460687072 0.992636100639958 0.764705882352941 27.3 27 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00609996244503025 0.0131718460687072 0.992636100639958 0.764705882352941 27.3 27 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.02738627118042e-13 1.76141043842137e-12 0.992015315086087 0.764227642276423 27.3 27 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.37599519886596e-08 9.23604324521822e-08 0.991575591985428 0.763888888888889 27.3 27 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.63859403822988e-23 1.87735965820056e-21 0.991247798401301 0.763636363636364 27.3 27 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 5.67871452947862e-08 3.20667094263812e-07 0.988077496274218 0.761194029850746 27.3 27 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 7.16653157284523e-06 2.82492366430991e-05 0.987656320870861 0.760869565217391 27.3 27 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.19832122703493e-13 4.89377538287172e-12 0.986956682390906 0.760330578512397 27.3 27 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.19832122703493e-13 4.89377538287172e-12 0.986956682390906 0.760330578512397 27.3 27 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 3.03638424580576e-06 1.25239848747293e-05 0.986527570789866 0.76 27.3 27 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000998922545998025 0.00267193004314885 0.986527570789866 0.76 27.3 27 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 9.65012892522493e-17 2.74642669211902e-15 0.985870323907261 0.759493670886076 27.3 27 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.53127461515177e-10 1.42418547539933e-09 0.983794807435877 0.757894736842105 27.3 27 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.53127461515177e-10 1.42418547539933e-09 0.983794807435877 0.757894736842105 27.3 27 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.53127461515177e-10 1.42418547539933e-09 0.983794807435877 0.757894736842105 27.3 27 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 4.53662035690946e-14 8.17165919985083e-13 0.983380752382243 0.757575757575758 27.3 27 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.99913033498652e-05 0.000109993878007366 0.981461960670277 0.75609756097561 27.3 27 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.99913033498652e-05 0.000109993878007366 0.981461960670277 0.75609756097561 27.3 27 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.99913033498652e-05 0.000109993878007366 0.981461960670277 0.75609756097561 27.3 27 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.99913033498652e-05 0.000109993878007366 0.981461960670277 0.75609756097561 27.3 27 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.45045809083691e-09 1.1794296361491e-08 0.981093820399959 0.755813953488372 27.3 27 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.26447171939658e-05 4.87626898835051e-05 0.980758403709223 0.755555555555556 27.3 27 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 5.34894811635003e-06 2.12020979653652e-05 0.98016971319079 0.755102040816326 27.3 27 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.08998187271743e-09 9.03348653624843e-09 0.97719318809759 0.752808988764045 27.3 27 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 7.3167046458285e-21 3.71845382536213e-19 0.976637570080193 0.752380952380952 27.3 27 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.74532992586431e-11 3.83424783057907e-10 0.976637570080193 0.752380952380952 27.3 27 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.51249700093381e-10 1.42418547539933e-09 0.97354694485842 0.75 27.3 27 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.06312668006876e-07 1.55648972556534e-06 0.97354694485842 0.75 27.3 27 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 9.36587464258774e-06 3.66143945505559e-05 0.97354694485842 0.75 27.3 27 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 5.26422761444162e-05 0.000184962861613591 0.97354694485842 0.75 27.3 27 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 5.26422761444162e-05 0.000184962861613591 0.97354694485842 0.75 27.3 27 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000125562732569564 0.000404243820014683 0.97354694485842 0.75 27.3 27 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00072679057763654 0.00206020516330039 0.97354694485842 0.75 27.3 27 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00176968006534927 0.0043643929514593 0.97354694485842 0.75 27.3 27 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00176968006534927 0.0043643929514593 0.97354694485842 0.75 27.3 27 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00435961002976248 0.00983157697678606 0.97354694485842 0.75 27.3 27 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00435961002976248 0.00983157697678606 0.97354694485842 0.75 27.3 27 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00435961002976248 0.00983157697678606 0.97354694485842 0.75 27.3 27 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00435961002976248 0.00983157697678606 0.97354694485842 0.75 27.3 27 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0109191134418719 0.0221969977539767 0.97354694485842 0.75 27.3 27 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0109191134418719 0.0221969977539767 0.97354694485842 0.75 27.3 27 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0109191134418719 0.0221969977539767 0.97354694485842 0.75 27.3 27 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0109191134418719 0.0221969977539767 0.97354694485842 0.75 27.3 27 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0280488523106525 0.0500169383935571 0.97354694485842 0.75 27.3 27 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0280488523106525 0.0500169383935571 0.97354694485842 0.75 27.3 27 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0280488523106525 0.0500169383935571 0.97354694485842 0.75 27.3 27 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0280488523106525 0.0500169383935571 0.97354694485842 0.75 27.3 27 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0752651097511723 0.120610643216124 0.97354694485842 0.75 27.3 27 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.68902320235208e-12 2.28902858756858e-11 0.970908606254468 0.747967479674797 27.3 27 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.27296462342903e-07 1.18477240261521e-06 0.968703427719821 0.746268656716418 27.3 27 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.70178584450314e-80 3.84464125672797e-77 0.967673358464101 0.745475113122172 27.3 27 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.58506661491945e-16 2.10630168845351e-14 0.965631929046563 0.74390243902439 27.3 27 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 9.73171350884696e-18 3.3776166641681e-16 0.964870055866812 0.74331550802139 27.3 27 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000218944325274645 0.00067583031424256 0.964275069193102 0.742857142857143 27.3 27 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.74481099327233e-12 4.8888679297491e-11 0.963078698139513 0.741935483870968 27.3 27 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.74481099327233e-12 4.8888679297491e-11 0.963078698139513 0.741935483870968 27.3 27 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.74481099327233e-12 4.8888679297491e-11 0.963078698139513 0.741935483870968 27.3 27 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000525562135940936 0.00153883728280648 0.963078698139513 0.741935483870968 27.3 27 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 9.80555920233656e-09 6.83985820829653e-08 0.962093451389498 0.741176470588235 27.3 27 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 9.80555920233656e-09 6.83985820829653e-08 0.962093451389498 0.741176470588235 27.3 27 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 9.80555920233656e-09 6.83985820829653e-08 0.962093451389498 0.741176470588235 27.3 27 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 9.80555920233656e-09 6.83985820829653e-08 0.962093451389498 0.741176470588235 27.3 27 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 9.80555920233656e-09 6.83985820829653e-08 0.962093451389498 0.741176470588235 27.3 27 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.28172396472813e-08 1.47586054627643e-07 0.961527846773748 0.740740740740741 27.3 27 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00127038422512013 0.00332920212218406 0.961527846773748 0.740740740740741 27.3 27 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00127038422512013 0.00332920212218406 0.961527846773748 0.740740740740741 27.3 27 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.49536319362758e-10 2.26172090734525e-09 0.961065573770492 0.740384615384615 27.3 27 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.89159679869529e-07 1.48012310954799e-06 0.959437568845979 0.739130434782609 27.3 27 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0030987075275063 0.00721679347240829 0.959437568845979 0.739130434782609 27.3 27 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 7.23719971696883e-09 5.36382041523263e-08 0.958796233572687 0.738636363636364 27.3 27 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.23719971696883e-09 5.36382041523263e-08 0.958796233572687 0.738636363636364 27.3 27 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 6.0413300549192e-16 1.52736999208068e-14 0.958453193775344 0.738372093023256 27.3 27 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.09943034965643e-11 1.33717041671889e-10 0.957587158877135 0.737704918032787 27.3 27 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.71308094702794e-14 3.43340026425459e-13 0.956905116741182 0.737179487179487 27.3 27 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000158527682397494 0.000504664188034976 0.956467173895992 0.736842105263158 27.3 27 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.23723859433e-08 8.42387808484011e-08 0.954896620244274 0.735632183908046 27.3 27 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.80179392424744e-16 4.8376467060455e-15 0.952382880839759 0.733695652173913 27.3 27 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000908524077295507 0.00245785125853899 0.951912568306011 0.733333333333333 27.3 27 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000908524077295507 0.00245785125853899 0.951912568306011 0.733333333333333 27.3 27 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0192274199296137 0.0358123279579062 0.951912568306011 0.733333333333333 27.3 27 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0192274199296137 0.0358123279579062 0.951912568306011 0.733333333333333 27.3 27 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0192274199296137 0.0358123279579062 0.951912568306011 0.733333333333333 27.3 27 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00011441765649319 0.000372577403180343 0.949801897422849 0.731707317073171 27.3 27 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00219618172192344 0.00535131265461825 0.948584202682563 0.730769230769231 27.3 27 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.13590598849692e-07 6.12270538496637e-07 0.948584202682563 0.730769230769231 27.3 27 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 3.96996039207328e-11 4.00656286377324e-10 0.946947301556277 0.729508196721312 27.3 27 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.57323467037432e-08 2.17295424612934e-07 0.946822126764267 0.729411764705882 27.3 27 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.57323467037432e-08 2.17295424612934e-07 0.946822126764267 0.729411764705882 27.3 27 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 6.14196714448111e-07 3.00344304006757e-06 0.945731317862465 0.728571428571429 27.3 27 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.12622243546252e-08 7.74209915779305e-08 0.945328192833539 0.728260869565217 27.3 27 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0053570682912446 0.0118555337145273 0.944045522286953 0.727272727272727 27.3 27 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0496367017339292 0.0825152179525483 0.944045522286953 0.727272727272727 27.3 27 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0496367017339292 0.0825152179525483 0.944045522286953 0.727272727272727 27.3 27 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0496367017339292 0.0825152179525483 0.944045522286953 0.727272727272727 27.3 27 3 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.0496367017339292 0.0825152179525483 0.944045522286953 0.727272727272727 27.3 27 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0496367017339292 0.0825152179525483 0.944045522286953 0.727272727272727 27.3 27 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0496367017339292 0.0825152179525483 0.944045522286953 0.727272727272727 27.3 27 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0496367017339292 0.0825152179525483 0.944045522286953 0.727272727272727 27.3 27 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0496367017339292 0.0825152179525483 0.944045522286953 0.727272727272727 27.3 27 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000194717684258031 0.000606309113127304 0.941095380029806 0.725 27.3 27 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00155425698751413 0.00392146754119256 0.939976360552958 0.724137931034483 27.3 27 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.23957910195432e-07 1.63472378087979e-06 0.939387402933563 0.723684210526316 27.3 27 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.01505373650489e-07 5.51305903452847e-07 0.938358501068357 0.72289156626506 27.3 27 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.51094851592044e-07 3.36538642338674e-06 0.937489650604405 0.722222222222222 27.3 27 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 7.3614170353161e-08 4.06019241909101e-07 0.93581256715073 0.720930232558139 27.3 27 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.000139317742837189 0.000447515006901398 0.93581256715073 0.720930232558139 27.3 27 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.74233143216565e-06 7.4454583422574e-06 0.935368633295345 0.720588235294118 27.3 27 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00375162797225248 0.00851446029428275 0.934605067064083 0.72 27.3 27 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00375162797225248 0.00851446029428275 0.934605067064083 0.72 27.3 27 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00375162797225248 0.00851446029428275 0.934605067064083 0.72 27.3 27 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00375162797225248 0.00851446029428275 0.934605067064083 0.72 27.3 27 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00375162797225248 0.00851446029428275 0.934605067064083 0.72 27.3 27 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.69976695240705e-07 8.95840138250085e-07 0.933971865799135 0.719512195121951 27.3 27 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 3.04692921706395e-05 0.00011145964719491 0.930686387537609 0.716981132075472 27.3 27 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.83364774019758e-07 1.4556970159932e-06 0.929476918547957 0.716049382716049 27.3 27 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 3.03217769153122e-19 1.30751177425725e-17 0.927932295500931 0.714859437751004 27.3 27 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000233714139172398 0.000716756939746383 0.927187566531829 0.714285714285714 27.3 27 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00913289679810917 0.0188076876175244 0.927187566531829 0.714285714285714 27.3 27 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.11132557097287e-05 0.00024443034510856 0.927187566531829 0.714285714285714 27.3 27 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 2.09446070542703e-06 8.81780350243393e-06 0.927187566531829 0.714285714285714 27.3 27 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.000777265752123699 0.00211481675960234 0.927187566531829 0.714285714285714 27.3 27 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0332322554846625 0.0582382999441808 0.927187566531829 0.714285714285714 27.3 27 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.134313441092288 0.196633772298689 0.927187566531829 0.714285714285714 27.3 27 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.45906409836021e-11 1.74474639661057e-10 0.925890800704512 0.713286713286713 27.3 27 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 4.83892573834388e-06 1.94513879256027e-05 0.924377907239308 0.712121212121212 27.3 27 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 1.56256745469748e-05 6.00954996766085e-05 0.924044557831721 0.711864406779661 27.3 27 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.08160768088442e-06 4.79479043582097e-06 0.922307631971135 0.710526315789474 27.3 27 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00184465326727336 0.00452576137815515 0.921205711263882 0.709677419354839 27.3 27 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00184465326727336 0.00452576137815515 0.921205711263882 0.709677419354839 27.3 27 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 3.96324554573361e-11 4.00656286377324e-10 0.920611768187632 0.709219858156028 27.3 27 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 3.62169485337777e-05 0.000129815409983793 0.920444384229779 0.709090909090909 27.3 27 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000118124798186489 0.000381160063082479 0.919461003477397 0.708333333333333 27.3 27 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00632634564988768 0.013598776223248 0.919461003477397 0.708333333333333 27.3 27 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00632634564988768 0.013598776223248 0.919461003477397 0.708333333333333 27.3 27 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 9.49234863607143e-38 1.35076121091297e-35 0.918853296270869 0.707865168539326 27.3 27 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 8.97272634165565e-09 6.44858059806868e-08 0.916979996992029 0.706422018348624 27.3 27 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00129550683770485 0.0033518295091891 0.916279477513807 0.705882352941177 27.3 27 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00129550683770485 0.0033518295091891 0.916279477513807 0.705882352941177 27.3 27 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00129550683770485 0.0033518295091891 0.916279477513807 0.705882352941177 27.3 27 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0224850758342918 0.0406559884526013 0.916279477513807 0.705882352941177 27.3 27 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0224850758342918 0.0406559884526013 0.916279477513807 0.705882352941177 27.3 27 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0224850758342918 0.0406559884526013 0.916279477513807 0.705882352941177 27.3 27 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0224850758342918 0.0406559884526013 0.916279477513807 0.705882352941177 27.3 27 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0224850758342918 0.0406559884526013 0.916279477513807 0.705882352941177 27.3 27 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0224850758342918 0.0406559884526013 0.916279477513807 0.705882352941177 27.3 27 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00439495077683131 0.00984884244949756 0.913451454435061 0.703703703703704 27.3 27 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00439495077683131 0.00984884244949756 0.913451454435061 0.703703703703704 27.3 27 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00439495077683131 0.00984884244949756 0.913451454435061 0.703703703703704 27.3 27 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00439495077683131 0.00984884244949756 0.913451454435061 0.703703703703704 27.3 27 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.26370771188604e-11 1.52394582543545e-10 0.912831113888755 0.703225806451613 27.3 27 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 4.86206544878448e-14 8.6483989170254e-13 0.912700260804769 0.703125 27.3 27 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 5.46920102271261e-10 4.74553235080491e-09 0.911616477628241 0.702290076335878 27.3 27 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 5.46920102271261e-10 4.74553235080491e-09 0.911616477628241 0.702290076335878 27.3 27 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00306096711135758 0.00714058393354398 0.908643815201192 0.7 27.3 27 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.00306096711135758 0.00714058393354398 0.908643815201192 0.7 27.3 27 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0153328616295744 0.0293567270460821 0.908643815201192 0.7 27.3 27 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0153328616295744 0.0293567270460821 0.908643815201192 0.7 27.3 27 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0153328616295744 0.0293567270460821 0.908643815201192 0.7 27.3 27 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0857222807360099 0.131446988671705 0.908643815201192 0.7 27.3 27 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.20404734909848e-17 6.64160430759265e-16 0.906583398386677 0.698412698412698 27.3 27 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.20404734909848e-17 6.64160430759265e-16 0.906583398386677 0.698412698412698 27.3 27 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.20404734909848e-17 6.64160430759265e-16 0.906583398386677 0.698412698412698 27.3 27 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.00213664573165226 0.00521517474466752 0.904710292191663 0.696969696969697 27.3 27 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00213664573165226 0.00521517474466752 0.904710292191663 0.696969696969697 27.3 27 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.99211263574358e-08 1.29441839299686e-07 0.904007877368533 0.696428571428571 27.3 27 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0105190357512178 0.0215065917729641 0.903000064796216 0.695652173913043 27.3 27 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 7.04583899050878e-50 2.0052457766988e-47 0.90249422289052 0.695262483994878 27.3 27 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.05618819052232e-14 4.06382749321285e-13 0.902462564757647 0.695238095238095 27.3 27 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 7.31220734170509e-09 5.3913321488323e-08 0.901134362183001 0.694214876033058 27.3 27 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000224684294467145 0.000692047080144474 0.900696493202348 0.693877551020408 27.3 27 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 5.23473255127017e-09 4.00485183895562e-08 0.900269217826066 0.693548387096774 27.3 27 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.00913011151674e-21 1.64692005718781e-19 0.899883883591014 0.693251533742331 27.3 27 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00725138203549281 0.0151745832889798 0.89865871833085 0.692307692307692 27.3 27 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0562253500451735 0.0931416450690127 0.89865871833085 0.692307692307692 27.3 27 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.0562253500451735 0.0931416450690127 0.89865871833085 0.692307692307692 27.3 27 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0562253500451735 0.0931416450690127 0.89865871833085 0.692307692307692 27.3 27 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00104699397632234 0.00278480827720876 0.89865871833085 0.692307692307692 27.3 27 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.47064262421169e-05 9.15553243295112e-05 0.898658718330849 0.692307692307692 27.3 27 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 5.16473045793365e-08 2.95157086009622e-07 0.896843246172605 0.690909090909091 27.3 27 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000734683501612998 0.00207843861390715 0.896281314314101 0.69047619047619 27.3 27 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.00348457936896105 0.00797195569458452 0.892418032786885 0.6875 27.3 27 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00348457936896105 0.00797195569458452 0.892418032786885 0.6875 27.3 27 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0375056942026457 0.0638404340315369 0.892418032786885 0.6875 27.3 27 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0375056942026457 0.0638404340315369 0.892418032786885 0.6875 27.3 27 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0375056942026457 0.0638404340315369 0.892418032786885 0.6875 27.3 27 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.002426214660791 0.00583193152416485 0.890100063870556 0.685714285714286 27.3 27 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00169331780416408 0.00419789413819771 0.888148090046278 0.684210526315789 27.3 27 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0253093024290997 0.0455311471006433 0.888148090046278 0.684210526315789 27.3 27 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 7.13164026574938e-06 2.81897891615594e-05 0.887283291516535 0.683544303797468 27.3 27 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00118424106416653 0.00314398327296451 0.886481770927992 0.682926829268293 27.3 27 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 6.35470051226955e-05 0.000219483952159213 0.885979230241525 0.682539682539683 27.3 27 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0172239578842475 0.0322072169110173 0.885042677144018 0.681818181818182 27.3 27 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 9.19025695058723e-07 4.09960364911775e-06 0.883217846881866 0.680412371134021 27.3 27 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00812229146872487 0.0168976911695841 0.880828188205237 0.678571428571429 27.3 27 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.00812229146872487 0.0168976911695841 0.880828188205237 0.678571428571429 27.3 27 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00812229146872487 0.0168976911695841 0.880828188205237 0.678571428571429 27.3 27 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00271015433803402 0.00649250778286602 0.877069319692271 0.675675675675676 27.3 27 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00132117023143978 0.00341202402783813 0.875437562818425 0.674418604651163 27.3 27 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.000925156380485067 0.00249336653301184 0.874781312771334 0.673913043478261 27.3 27 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.000648908779704603 0.0018431081706979 0.874205419872867 0.673469387755102 27.3 27 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00102026345752962 0.0027187919476866 0.865375062096374 0.666666666666667 27.3 27 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00102026345752962 0.0027187919476866 0.865375062096374 0.666666666666667 27.3 27 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00298596545984755 0.00699813921272526 0.865375062096374 0.666666666666667 27.3 27 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00298596545984755 0.00699813921272526 0.865375062096374 0.666666666666667 27.3 27 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00298596545984755 0.00699813921272526 0.865375062096374 0.666666666666667 27.3 27 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00618044664357865 0.0133254175360794 0.865375062096374 0.666666666666667 27.3 27 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00893357985087193 0.0184238900402765 0.865375062096374 0.666666666666667 27.3 27 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0129642445528158 0.0257655307243812 0.865375062096374 0.666666666666667 27.3 27 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0409998142185831 0.0688968214190602 0.865375062096374 0.666666666666667 27.3 27 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0612419265947603 0.0997108255656108 0.865375062096374 0.666666666666667 27.3 27 3 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.0928124005804828 0.141860414635904 0.865375062096374 0.666666666666667 27.3 27 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0928124005804828 0.141860414635904 0.865375062096374 0.666666666666667 27.3 27 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0928124005804828 0.141860414635904 0.865375062096374 0.666666666666667 27.3 27 3 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.143777609307004 0.208345761755465 0.865375062096374 0.666666666666667 27.3 27 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.143777609307004 0.208345761755465 0.865375062096374 0.666666666666667 27.3 27 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.143777609307004 0.208345761755465 0.865375062096374 0.666666666666667 27.3 27 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.143777609307004 0.208345761755465 0.865375062096374 0.666666666666667 27.3 27 3 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.143777609307004 0.208345761755465 0.865375062096374 0.666666666666667 27.3 27 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.143777609307004 0.208345761755465 0.865375062096374 0.666666666666667 27.3 27 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00145661134032601 0.00374144032000707 0.865375062096373 0.666666666666667 27.3 27 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.78823377977888e-09 5.11092945429912e-08 0.862583529637998 0.664516129032258 27.3 27 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.04716035488412e-14 2.128727407143e-13 0.862250964399275 0.664259927797834 27.3 27 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.000782358705322256 0.00212461152227781 0.857211146416219 0.660377358490566 27.3 27 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 7.39610063887796e-05 0.000250712895382895 0.853988548121421 0.657894736842105 27.3 27 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.60026587423196e-72 1.13858916951604e-69 0.853084389813533 0.657198192382182 27.3 27 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.43753405558705e-23 1.13645053394465e-21 0.852263318731277 0.656565656565657 27.3 27 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00968282464888366 0.0198826255055721 0.851853576751118 0.65625 27.3 27 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00120681990291085 0.00319201621160249 0.848733233979136 0.653846153846154 27.3 27 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00120681990291085 0.00319201621160249 0.848733233979136 0.653846153846154 27.3 27 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0203849604425607 0.0377705712366717 0.848733233979136 0.653846153846154 27.3 27 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00245308939002778 0.00588658718719988 0.846562560746452 0.652173913043478 27.3 27 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.029795686883678 0.0524094714900788 0.846562560746452 0.652173913043478 27.3 27 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.26522671237763e-09 1.04070382179964e-08 0.84509283407849 0.651041666666667 27.3 27 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.000913109113024676 0.00246556787065297 0.842602034146469 0.649122807017544 27.3 27 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0103697158886453 0.0212318067763199 0.839922854387657 0.647058823529412 27.3 27 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.065043494544628 0.105779305985149 0.839922854387657 0.647058823529412 27.3 27 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 8.70972788023962e-28 8.26262851572065e-26 0.839804103807367 0.64696734059098 27.3 27 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.37617701023804e-06 6.04413544928623e-06 0.838119154628771 0.645669291338583 27.3 27 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 9.78045921692091e-06 3.80975215227754e-05 0.837068401186679 0.644859813084112 27.3 27 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.59365663992744e-11 1.88981116551396e-10 0.834832412845913 0.643137254901961 27.3 27 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0976129202540934 0.148878012348955 0.834468809878646 0.642857142857143 27.3 27 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000139696607974534 0.000447721335918383 0.833324133870582 0.641975308641975 27.3 27 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.43919701017488e-40 2.92568192211265e-38 0.832891013218882 0.641641641641642 27.3 27 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0315387186010175 0.0553385900977162 0.830760059612519 0.64 27.3 27 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0315387186010175 0.0553385900977162 0.830760059612519 0.64 27.3 27 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0109953674344294 0.0222883302837507 0.829317767842358 0.638888888888889 27.3 27 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00147015126695952 0.00375588016675654 0.828074412868082 0.637931034482759 27.3 27 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00147015126695952 0.00375588016675654 0.828074412868082 0.637931034482759 27.3 27 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00147015126695952 0.00375588016675654 0.828074412868082 0.637931034482759 27.3 27 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 2.69502970554963e-07 1.38950263441925e-06 0.826791460601631 0.636942675159236 27.3 27 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0158119861581675 0.0297231919459344 0.826039832001084 0.636363636363636 27.3 27 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.148872043989651 0.214852858617924 0.826039832001084 0.636363636363636 27.3 27 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.148872043989651 0.214852858617924 0.826039832001084 0.636363636363636 27.3 27 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.148872043989651 0.214852858617924 0.826039832001084 0.636363636363636 27.3 27 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.35792076230487e-19 6.03850388987448e-18 0.825799983037088 0.636178861788618 27.3 27 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.02124775447694e-22 1.30737979755485e-20 0.825213172174213 0.635726795096322 27.3 27 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.24754721496258e-17 4.12851089974826e-16 0.823658551255405 0.634529147982063 27.3 27 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00808749252719952 0.0168976911695841 0.823161644433136 0.634146341463415 27.3 27 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0228042339285765 0.0411285486443148 0.822106308991555 0.633333333333333 27.3 27 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0228042339285765 0.0411285486443148 0.822106308991555 0.633333333333333 27.3 27 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0678978344291262 0.110169462249312 0.819829006196564 0.631578947368421 27.3 27 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0678978344291262 0.110169462249312 0.819829006196564 0.631578947368421 27.3 27 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000326575693338552 0.000990868255054923 0.817298669757686 0.62962962962963 27.3 27 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0237738259969129 0.0428229802450722 0.81128912071535 0.625 27.3 27 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.100802313914951 0.153086118144051 0.81128912071535 0.625 27.3 27 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.100802313914951 0.153086118144051 0.81128912071535 0.625 27.3 27 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.232727326660815 0.298621267663065 0.81128912071535 0.625 27.3 27 3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.232727326660815 0.298621267663065 0.81128912071535 0.625 27.3 27 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.232727326660815 0.298621267663065 0.81128912071535 0.625 27.3 27 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.232727326660815 0.298621267663065 0.81128912071535 0.625 27.3 27 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.232727326660815 0.298621267663065 0.81128912071535 0.625 27.3 27 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.232727326660815 0.298621267663065 0.81128912071535 0.625 27.3 27 3 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.232727326660815 0.298621267663065 0.81128912071535 0.625 27.3 27 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00240067051058464 0.00578029464731293 0.808629156385136 0.622950819672131 27.3 27 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.000199490369109062 0.000619813963410908 0.806165189426622 0.621052631578947 27.3 27 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0493847316545483 0.0825152179525483 0.798807749627422 0.615384615384615 27.3 27 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.151351681436978 0.217329407350978 0.798807749627422 0.615384615384615 27.3 27 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.151351681436978 0.217329407350978 0.798807749627422 0.615384615384615 27.3 27 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.151351681436978 0.217329407350978 0.798807749627422 0.615384615384615 27.3 27 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.151351681436978 0.217329407350978 0.798807749627422 0.615384615384615 27.3 27 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00191015268846116 0.0046783946225133 0.797381307217373 0.614285714285714 27.3 27 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0352132665710311 0.0613842203466424 0.795586750636989 0.612903225806452 27.3 27 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0352132665710311 0.0613842203466424 0.795586750636989 0.612903225806452 27.3 27 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0352132665710311 0.0613842203466424 0.795586750636989 0.612903225806452 27.3 27 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000776834666454125 0.00211481675960234 0.794108880511966 0.611764705882353 27.3 27 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000776834666454125 0.00211481675960234 0.794108880511966 0.611764705882353 27.3 27 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.102826420771269 0.155993599954708 0.793260473588342 0.611111111111111 27.3 27 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00061064066286541 0.00175189851463201 0.787123061800425 0.606382978723404 27.3 27 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0360228103642135 0.0615371658442688 0.786704601905794 0.606060606060606 27.3 27 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0360228103642135 0.0615371658442688 0.786704601905794 0.606060606060606 27.3 27 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0258964494327255 0.0465285953822833 0.785669464271708 0.605263157894737 27.3 27 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0138804400348431 0.0275479305015086 0.778837555886736 0.6 27.3 27 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0725614348485012 0.117468625471464 0.778837555886736 0.6 27.3 27 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.152169410743093 0.217406698280543 0.778837555886736 0.6 27.3 27 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.152169410743093 0.217406698280543 0.778837555886736 0.6 27.3 27 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.230860602163495 0.298605270040303 0.778837555886736 0.6 27.3 27 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.230860602163495 0.298605270040303 0.778837555886736 0.6 27.3 27 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.230860602163495 0.298605270040303 0.778837555886736 0.6 27.3 27 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.230860602163495 0.298605270040303 0.778837555886736 0.6 27.3 27 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.230860602163495 0.298605270040303 0.778837555886736 0.6 27.3 27 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.230860602163495 0.298605270040303 0.778837555886736 0.6 27.3 27 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.230860602163495 0.298605270040303 0.778837555886736 0.6 27.3 27 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0101284058900094 0.0207676103479587 0.778837555886736 0.6 27.3 27 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.104503995053569 0.158233220495843 0.767036986858149 0.590909090909091 27.3 27 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.151886341586841 0.217406698280543 0.763566231261506 0.588235294117647 27.3 27 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.151886341586841 0.217406698280543 0.763566231261506 0.588235294117647 27.3 27 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.151886341586841 0.217406698280543 0.763566231261506 0.588235294117647 27.3 27 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.84730745296638e-05 6.99127262119989e-05 0.757752275185911 0.583756345177665 27.3 27 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 3.41031641287776e-06 1.39450582055317e-05 0.757667436341889 0.583690987124464 27.3 27 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0275128790611737 0.0493083462267635 0.757203179334327 0.583333333333333 27.3 27 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.104525107003579 0.158233220495843 0.757203179334327 0.583333333333333 27.3 27 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.227355544762486 0.298605270040303 0.757203179334327 0.583333333333333 27.3 27 3 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.227355544762486 0.298605270040303 0.757203179334327 0.583333333333333 27.3 27 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.227355544762486 0.298605270040303 0.757203179334327 0.583333333333333 27.3 27 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.227355544762486 0.298605270040303 0.757203179334327 0.583333333333333 27.3 27 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.227355544762486 0.298605270040303 0.757203179334327 0.583333333333333 27.3 27 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0201421019678438 0.0374180301569735 0.755236417829562 0.581818181818182 27.3 27 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0201421019678438 0.0374180301569735 0.755236417829562 0.581818181818182 27.3 27 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0109375575756195 0.0222027737947312 0.752500053996847 0.579710144927536 27.3 27 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0044767194545084 0.0100163078361092 0.749991720483524 0.577777777777778 27.3 27 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0380460783838996 0.0646136358060582 0.749991720483524 0.577777777777778 27.3 27 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0202967589861789 0.0376561773628848 0.744790012459994 0.573770491803279 27.3 27 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.149299567906138 0.215251555349984 0.741750053225463 0.571428571428571 27.3 27 3 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.223003363014157 0.295744441350555 0.741750053225463 0.571428571428571 27.3 27 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00452175798583706 0.010023070440914 0.739895678092399 0.57 27.3 27 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00607233645260555 0.0131718460687072 0.739756101469481 0.56989247311828 27.3 27 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.147381003462095 0.213350119965983 0.733687552646925 0.565217391304348 27.3 27 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0272508093869787 0.0489002544232923 0.730160208643815 0.5625 27.3 27 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.100361943538064 0.152743364336541 0.725387919698431 0.558823529411765 27.3 27 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0143414256409835 0.0284231875865174 0.722784853000948 0.556818181818182 27.3 27 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.142852554641623 0.208277853744907 0.721145885080311 0.555555555555556 27.3 27 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.213211242606307 0.292011162876588 0.721145885080311 0.555555555555556 27.3 27 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.213211242606307 0.292011162876588 0.721145885080311 0.555555555555556 27.3 27 3 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.343914473353078 0.43194200845669 0.721145885080311 0.555555555555556 27.3 27 3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.343914473353078 0.43194200845669 0.721145885080311 0.555555555555556 27.3 27 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.343914473353078 0.43194200845669 0.721145885080311 0.555555555555556 27.3 27 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 9.73761389012591e-05 0.000318543093463199 0.717752257385816 0.552941176470588 27.3 27 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00172742731647761 0.0042750070806046 0.71756255148985 0.552795031055901 27.3 27 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.140376677306779 0.205088307810623 0.716172465183206 0.551724137931034 27.3 27 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.208131581480836 0.285603896284696 0.713934426229508 0.55 27.3 27 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00221022091209995 0.00537631514174057 0.713133153023863 0.549382716049383 27.3 27 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.329246871972109 0.41572164934899 0.708034141715215 0.545454545454545 27.3 27 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.129943130286457 0.192013576736893 0.701655455753816 0.540540540540541 27.3 27 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.316026718642246 0.403685835393102 0.698956780923994 0.538461538461538 27.3 27 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.316026718642246 0.403685835393102 0.698956780923994 0.538461538461538 27.3 27 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.316026718642246 0.403685835393102 0.698956780923994 0.538461538461538 27.3 27 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.127309379625915 0.188317304789686 0.698956780923994 0.538461538461538 27.3 27 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.085230012895994 0.131446988671705 0.697107688910968 0.537037037037037 27.3 27 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.183517663358916 0.260078719954705 0.692300049677099 0.533333333333333 27.3 27 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.303956451323944 0.389315958806456 0.692300049677099 0.533333333333333 27.3 27 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0115313399210556 0.0229497856051218 0.686716984760348 0.529032258064516 27.3 27 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00891615317414493 0.0184146385585025 0.680605792081202 0.524324324324324 27.3 27 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.016746041790343 0.0313547598258659 0.677605001452821 0.522012578616352 27.3 27 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.016746041790343 0.0313547598258659 0.677605001452821 0.522012578616352 27.3 27 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0161400171489086 0.030299794726777 0.676903806241028 0.521472392638037 27.3 27 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.255253512631502 0.327230404031195 0.674992548435171 0.52 27.3 27 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.225335190284793 0.298280907697917 0.668698911619925 0.515151515151515 27.3 27 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.225335190284793 0.298280907697917 0.668698911619925 0.515151515151515 27.3 27 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.317420747762454 0.405102891538988 0.64903129657228 0.5 27.3 27 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0718220472485327 0.116404069743351 0.64903129657228 0.5 27.3 27 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.32954854272819 0.415733666934587 0.64903129657228 0.5 27.3 27 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.342639337496786 0.431482988723829 0.64903129657228 0.5 27.3 27 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.342639337496786 0.431482988723829 0.64903129657228 0.5 27.3 27 3 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.372448977863791 0.464907803070329 0.64903129657228 0.5 27.3 27 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.389700081697185 0.478466968296026 0.64903129657228 0.5 27.3 27 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.389700081697185 0.478466968296026 0.64903129657228 0.5 27.3 27 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.389700081697185 0.478466968296026 0.64903129657228 0.5 27.3 27 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.389700081697185 0.478466968296026 0.64903129657228 0.5 27.3 27 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.389700081697185 0.478466968296026 0.64903129657228 0.5 27.3 27 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.409050074270335 0.491205279060495 0.64903129657228 0.5 27.3 27 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.409050074270335 0.491205279060495 0.64903129657228 0.5 27.3 27 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.409050074270335 0.491205279060495 0.64903129657228 0.5 27.3 27 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.409050074270335 0.491205279060495 0.64903129657228 0.5 27.3 27 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.431138199181733 0.513447139572351 0.64903129657228 0.5 27.3 27 3 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.45696834454266 0.537409879573724 0.64903129657228 0.5 27.3 27 3 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.45696834454266 0.537409879573724 0.64903129657228 0.5 27.3 27 3 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.45696834454266 0.537409879573724 0.64903129657228 0.5 27.3 27 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0958481897033846 0.146343319686606 0.639890010705065 0.492957746478873 27.3 27 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.117496105516606 0.173982266545401 0.634818932413763 0.489051094890511 27.3 27 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0997906872177657 0.15203656093242 0.633201264948566 0.48780487804878 27.3 27 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.136830871087953 0.200113391118353 0.629942140790743 0.485294117647059 27.3 27 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.154804033450051 0.2209489865591 0.625344022974752 0.481751824817518 27.3 27 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.453404923980938 0.534544496126657 0.614871754647423 0.473684210526316 27.3 27 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.327165634137121 0.41572164934899 0.599105812220566 0.461538461538462 27.3 27 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.563402905018119 0.651806775480312 0.590028451429346 0.454545454545455 27.3 27 3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.563402905018119 0.651806775480312 0.590028451429346 0.454545454545455 27.3 27 3 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.563402905018119 0.651806775480312 0.590028451429346 0.454545454545455 27.3 27 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.532392730340086 0.618444779815463 0.584128166915052 0.45 27.3 27 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.532392730340086 0.618444779815463 0.584128166915052 0.45 27.3 27 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.140663092824592 0.205295980604506 0.580012358692886 0.446829268292683 27.3 27 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.558492919103316 0.647706131934816 0.576916708064249 0.444444444444444 27.3 27 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.502303631023658 0.586845703568691 0.574552295326281 0.442622950819672 27.3 27 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.557105558993468 0.646624152078063 0.571147540983607 0.44 27.3 27 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.577018512519185 0.66701652584468 0.558659850214115 0.430379746835443 27.3 27 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.591262150556877 0.674712141333149 0.556312539919097 0.428571428571429 27.3 27 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.599602672818553 0.683681573253847 0.556312539919097 0.428571428571429 27.3 27 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.620371513674513 0.703978200924109 0.556312539919097 0.428571428571429 27.3 27 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.624201213243901 0.707759622666193 0.550693221334056 0.424242424242424 27.3 27 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.615753596683214 0.699295585060027 0.550693221334056 0.424242424242424 27.3 27 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.634920551919592 0.719340720845207 0.54655267079771 0.421052631578947 27.3 27 3 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.657877694901252 0.74239489281878 0.540859413810234 0.416666666666667 27.3 27 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.683401920796773 0.760939697412995 0.528840315725562 0.407407407407407 27.3 27 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.737923015151226 0.817170778646066 0.499254843517139 0.384615384615385 27.3 27 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.807064921495284 0.88820833974307 0.497130354821321 0.382978723404255 27.3 27 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.823803031392954 0.895547527633441 0.482137534596551 0.371428571428571 27.3 27 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.791983955992931 0.874994696722004 0.478233586947996 0.368421052631579 27.3 27 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999183633696359 1 0.465027578471891 0.358247422680412 27.3 27 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.80322940486051 0.884671395601011 0.463593783265914 0.357142857142857 27.3 27 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.80322940486051 0.884671395601011 0.463593783265914 0.357142857142857 27.3 27 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.80322940486051 0.884671395601011 0.463593783265914 0.357142857142857 27.3 27 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.80322940486051 0.884671395601011 0.463593783265914 0.357142857142857 27.3 27 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.942040217839682 0.997913602091795 0.460072817823388 0.354430379746835 27.3 27 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.839751699157727 0.908719899544825 0.454321907600596 0.35 27.3 27 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999362910413785 1 0.445050031935278 0.342857142857143 27.3 27 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.939973013289901 0.997913602091795 0.440851446728341 0.339622641509434 27.3 27 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.878293485793213 0.948263755905722 0.432687531048187 0.333333333333333 27.3 27 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.854870177344813 0.92367521819413 0.432687531048187 0.333333333333333 27.3 27 3 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.854870177344813 0.92367521819413 0.432687531048187 0.333333333333333 27.3 27 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.906275544399362 0.971838809103461 0.432687531048187 0.333333333333333 27.3 27 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.979119244761269 1 0.4204991498919 0.323943661971831 27.3 27 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999365704313169 1 0.41872986875631 0.32258064516129 27.3 27 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.921850182788046 0.984609630574849 0.417234404939323 0.321428571428571 27.3 27 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999849277671142 1 0.412748013488362 0.317972350230415 27.3 27 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.9487219584533 1 0.407962529274005 0.314285714285714 27.3 27 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.967078287725652 1 0.376856881880679 0.290322580645161 27.3 27 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.977875158585578 1 0.375754961173425 0.289473684210526 27.3 27 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99998770179956 1 0.368767782143341 0.284090909090909 27.3 27 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.987177547337011 1 0.343604804067678 0.264705882352941 27.3 27 3 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.9739788172271 1 0.338625024298581 0.260869565217391 27.3 27 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.987030150245255 1 0.334983895005048 0.258064516129032 27.3 27 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.997556109787268 1 0.32451564828614 0.25 27.3 27 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.314979084314675 0.242653232577666 27.3 27 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999991996701541 1 0.312496550201468 0.240740740740741 27.3 27 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.995656801024938 1 0.293110908129417 0.225806451612903 27.3 27 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.995656801024938 1 0.293110908129417 0.225806451612903 27.3 27 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999997692073518 1 0.274035436330518 0.211111111111111 27.3 27 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.264072408189445 0.203435804701627 27.3 27 3 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999972108943827 1 0.220946824365032 0.170212765957447 27.3 27 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999996202695622 1 0.189300794833582 0.145833333333333 27.3 27 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0167491947502524 0.0129032258064516 27.3 27 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.99898398521139e-12 2.76170311743282e-11 0.69501349055661 1 27.2 27 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.99898398521139e-12 2.76170311743282e-11 0.69501349055661 1 27.2 27 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.44465199490084e-07 3.0085536414776e-06 0.69501349055661 1 27.2 27 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 1.09295984252126e-06 4.96895161631868e-06 0.69501349055661 1 27.2 27 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.09295984252126e-06 4.96895161631868e-06 0.69501349055661 1 27.2 27 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.85353172753155e-06 7.92064759242459e-06 0.69501349055661 1 27.2 27 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 1.85353172753155e-06 7.92064759242459e-06 0.69501349055661 1 27.2 27 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 1.85353172753155e-06 7.92064759242459e-06 0.69501349055661 1 27.2 27 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 1.85353172753155e-06 7.92064759242459e-06 0.69501349055661 1 27.2 27 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 4.40745361406347e-05 0.000157583077708852 0.69501349055661 1 27.2 27 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 4.40745361406347e-05 0.000157583077708852 0.69501349055661 1 27.2 27 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 4.40745361406347e-05 0.000157583077708852 0.69501349055661 1 27.2 27 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 4.40745361406347e-05 0.000157583077708852 0.69501349055661 1 27.2 27 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 4.40745361406347e-05 0.000157583077708852 0.69501349055661 1 27.2 27 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00012672015619653 0.000407049169904431 0.69501349055661 1 27.2 27 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.000214862839099508 0.000653311581279059 0.69501349055661 1 27.2 27 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00104726042691615 0.00271448376594112 0.69501349055661 1 27.2 27 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0146678191424504 0.0278668980503431 0.69501349055661 1 27.2 27 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 5.7549058918935e-12 6.6579114505402e-11 0.69501349055661 1 27.2 27 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 5.54824384945772e-09 3.81408260762239e-08 0.69501349055661 1 27.2 27 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 5.54824384945772e-09 3.81408260762239e-08 0.69501349055661 1 27.2 27 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 5.54824384945772e-09 3.81408260762239e-08 0.69501349055661 1 27.2 27 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 2.24059443007012e-07 1.18526612415977e-06 0.69501349055661 1 27.2 27 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 3.80001945370042e-07 1.8686855169689e-06 0.69501349055661 1 27.2 27 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 5.33046281862878e-06 2.16103948458939e-05 0.69501349055661 1 27.2 27 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.33046281862878e-06 2.16103948458939e-05 0.69501349055661 1 27.2 27 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 9.03928323715254e-06 3.59298883979555e-05 0.69501349055661 1 27.2 27 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 9.03928323715254e-06 3.59298883979555e-05 0.69501349055661 1 27.2 27 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 9.03928323715254e-06 3.59298883979555e-05 0.69501349055661 1 27.2 27 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 1.53283058865194e-05 5.94337309986841e-05 0.69501349055661 1 27.2 27 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.59923418413801e-05 9.63205792715726e-05 0.69501349055661 1 27.2 27 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.59923418413801e-05 9.63205792715726e-05 0.69501349055661 1 27.2 27 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 2.59923418413801e-05 9.63205792715726e-05 0.69501349055661 1 27.2 27 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 2.59923418413801e-05 9.63205792715726e-05 0.69501349055661 1 27.2 27 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 2.59923418413801e-05 9.63205792715726e-05 0.69501349055661 1 27.2 27 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 2.59923418413801e-05 9.63205792715726e-05 0.69501349055661 1 27.2 27 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 2.59923418413801e-05 9.63205792715726e-05 0.69501349055661 1 27.2 27 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 7.47345080208223e-05 0.000253207630746738 0.69501349055661 1 27.2 27 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 7.47345080208223e-05 0.000253207630746738 0.69501349055661 1 27.2 27 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 7.47345080208223e-05 0.000253207630746738 0.69501349055661 1 27.2 27 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 7.47345080208223e-05 0.000253207630746738 0.69501349055661 1 27.2 27 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 7.47345080208223e-05 0.000253207630746738 0.69501349055661 1 27.2 27 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000364307415922057 0.00104941184788884 0.69501349055661 1 27.2 27 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.000364307415922057 0.00104941184788884 0.69501349055661 1 27.2 27 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000364307415922057 0.00104941184788884 0.69501349055661 1 27.2 27 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.000364307415922057 0.00104941184788884 0.69501349055661 1 27.2 27 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000364307415922057 0.00104941184788884 0.69501349055661 1 27.2 27 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000364307415922057 0.00104941184788884 0.69501349055661 1 27.2 27 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000364307415922057 0.00104941184788884 0.69501349055661 1 27.2 27 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000364307415922057 0.00104941184788884 0.69501349055661 1 27.2 27 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000617683223695846 0.0016870695342019 0.69501349055661 1 27.2 27 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0017755572241566 0.00428967390488089 0.69501349055661 1 27.2 27 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0030102720663312 0.00685378744062287 0.69501349055661 1 27.2 27 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0030102720663312 0.00685378744062287 0.69501349055661 1 27.2 27 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0030102720663312 0.00685378744062287 0.69501349055661 1 27.2 27 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0030102720663312 0.00685378744062287 0.69501349055661 1 27.2 27 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0030102720663312 0.00685378744062287 0.69501349055661 1 27.2 27 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0030102720663312 0.00685378744062287 0.69501349055661 1 27.2 27 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0030102720663312 0.00685378744062287 0.69501349055661 1 27.2 27 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0030102720663312 0.00685378744062287 0.69501349055661 1 27.2 27 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.00510349764334914 0.0110034502219482 0.69501349055661 1 27.2 27 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00865209310543295 0.0176284658006466 0.69501349055661 1 27.2 27 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0248657180913926 0.0448465359240198 0.69501349055661 1 27.2 27 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_217410.1 ACTIVATION OF TRKA RECEPTORS 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_223937.1 FGFR2B LIGAND BINDING AND ACTIVATION 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_196559.2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 SCAVENGING BY CLASS B RECEPTORS%REACTOME%REACT_196592.2 SCAVENGING BY CLASS B RECEPTORS 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0421529101471339 0.0695431642645989 0.69501349055661 1 27.2 27 2 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%REACT_208690.1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%REACT_209262.1 CLEAVAGE OF THE DAMAGED PYRIMIDINE 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%REACT_224446.1 TELOMERE C-STRAND SYNTHESIS INITIATION 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%REACT_215995.1 NOSTRIN MEDIATED ENOS TRAFFICKING 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220836.1 FGFR1B LIGAND BINDING AND ACTIVATION 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_196569.2 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605564 MUSCARINIC ACETYLCHOLINE RECEPTORS 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 DEPYRIMIDINATION%REACTOME%REACT_206945.1 DEPYRIMIDINATION 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604606 DNA REPLICATION INITIATION 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%REACT_209347.1 NGF-INDEPENDANT TRKA ACTIVATION 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0714570722815051 0.109690845584231 0.69501349055661 1 27.2 27 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.01553953798569e-14 3.63052248424511e-13 0.684640154876661 0.985074626865672 27.2 27 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.01553953798569e-14 3.63052248424511e-13 0.684640154876661 0.985074626865672 27.2 27 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.57450296917656e-13 2.54604286947528e-12 0.683981530389045 0.984126984126984 27.2 27 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.22483033476626e-12 1.854184645077e-11 0.683233600886159 0.983050847457627 27.2 27 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.22483033476626e-12 1.854184645077e-11 0.683233600886159 0.983050847457627 27.2 27 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 9.28730456004583e-10 6.95570230997117e-09 0.679904501631467 0.978260869565217 27.2 27 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.54237344189971e-09 1.131338870012e-08 0.679568746322019 0.977777777777778 27.2 27 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.56023030283943e-09 1.84934402078198e-08 0.679217729407596 0.977272727272727 27.2 27 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.89984790524492e-15 4.29124376057702e-14 0.67719263182439 0.974358974358974 27.2 27 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 8.60017350040272e-15 1.79971277809898e-13 0.676479797475101 0.973333333333333 27.2 27 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 8.75341559733501e-08 5.10496327664251e-07 0.676229342163189 0.972972972972973 27.2 27 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.88025899915271e-14 6.81680068616581e-13 0.675707560263371 0.972222222222222 27.2 27 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.44611189445055e-07 8.16594137223467e-07 0.675707560263371 0.972222222222222 27.2 27 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.87674676707107e-13 4.54845627726904e-12 0.674571917304945 0.970588235294118 27.2 27 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 3.93800926286197e-07 1.92570006221738e-06 0.674571917304945 0.970588235294118 27.2 27 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.74183181629624e-13 7.33437682020604e-12 0.674266819196711 0.970149253731343 27.2 27 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 6.29048723678559e-19 2.23784083448647e-17 0.674163085839912 0.97 27.2 27 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 6.49069548793833e-07 3.0085536414776e-06 0.673952475691259 0.96969696969697 27.2 27 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 6.49069548793833e-07 3.0085536414776e-06 0.673952475691259 0.96969696969697 27.2 27 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 6.49069548793833e-07 3.0085536414776e-06 0.673952475691259 0.96969696969697 27.2 27 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 6.49069548793833e-07 3.0085536414776e-06 0.673952475691259 0.96969696969697 27.2 27 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.70793406996209e-18 5.40086707012456e-17 0.673737567376306 0.969387755102041 27.2 27 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.06888379140459e-06 4.89074480761651e-06 0.673294318976716 0.96875 27.2 27 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 1.06888379140459e-06 4.89074480761651e-06 0.673294318976716 0.96875 27.2 27 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.7586210087214e-06 7.67643464849862e-06 0.672593700538655 0.967741935483871 27.2 27 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.54672818490375e-11 1.42921701760911e-10 0.671846374204723 0.966666666666667 27.2 27 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.54672818490375e-11 1.42921701760911e-10 0.671846374204723 0.966666666666667 27.2 27 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.54672818490375e-11 1.42921701760911e-10 0.671846374204723 0.966666666666667 27.2 27 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.54672818490375e-11 1.42921701760911e-10 0.671846374204723 0.966666666666667 27.2 27 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.54672818490375e-11 1.42921701760911e-10 0.671846374204723 0.966666666666667 27.2 27 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.54672818490375e-11 1.42921701760911e-10 0.671846374204723 0.966666666666667 27.2 27 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.54672818490375e-11 1.42921701760911e-10 0.671846374204723 0.966666666666667 27.2 27 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 2.8906279255147e-06 1.21697146094894e-05 0.671846374204723 0.966666666666667 27.2 27 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.8906279255147e-06 1.21697146094894e-05 0.671846374204723 0.966666666666667 27.2 27 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.08904547332436e-15 2.54051099760748e-14 0.670483602654612 0.964705882352941 27.2 27 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 7.78497306073124e-06 3.12938323881937e-05 0.670191580179589 0.964285714285714 27.2 27 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 7.78497306073124e-06 3.12938323881937e-05 0.670191580179589 0.964285714285714 27.2 27 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.27538205613317e-05 4.97224292021235e-05 0.669272250165625 0.962962962962963 27.2 27 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 1.27538205613317e-05 4.97224292021235e-05 0.669272250165625 0.962962962962963 27.2 27 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.37755736636102e-28 3.46070229573985e-26 0.668950484660737 0.9625 27.2 27 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.28159526617424e-14 2.56860572361401e-13 0.668950484660737 0.9625 27.2 27 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 2.08678288527888e-05 7.98250549933293e-05 0.668282202458279 0.961538461538462 27.2 27 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.08678288527888e-05 7.98250549933293e-05 0.668282202458279 0.961538461538462 27.2 27 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 2.08678288527888e-05 7.98250549933293e-05 0.668282202458279 0.961538461538462 27.2 27 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 2.08678288527888e-05 7.98250549933293e-05 0.668282202458279 0.961538461538462 27.2 27 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 2.08678288527888e-05 7.98250549933293e-05 0.668282202458279 0.961538461538462 27.2 27 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 2.13818137798534e-09 1.56032415429392e-08 0.667212950934346 0.96 27.2 27 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 3.48667866925384e-09 2.49323806349156e-08 0.666645592982871 0.959183673469388 27.2 27 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 5.68098164571086e-09 3.86796023054859e-08 0.666054595116752 0.958333333333333 27.2 27 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 5.68098164571086e-09 3.86796023054859e-08 0.666054595116752 0.958333333333333 27.2 27 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 5.5635025208054e-05 0.000193566359097948 0.666054595116752 0.958333333333333 27.2 27 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 5.5635025208054e-05 0.000193566359097948 0.666054595116752 0.958333333333333 27.2 27 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 5.5635025208054e-05 0.000193566359097948 0.666054595116752 0.958333333333333 27.2 27 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 5.5635025208054e-05 0.000193566359097948 0.666054595116752 0.958333333333333 27.2 27 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 9.24835852883921e-09 6.0647069984047e-08 0.665438448405265 0.957446808510638 27.2 27 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 9.24835852883921e-09 6.0647069984047e-08 0.665438448405265 0.957446808510638 27.2 27 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.28861507493735e-23 8.73190119826593e-22 0.665012908230426 0.956834532374101 27.2 27 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.77866352358365e-12 3.40865361556857e-11 0.664795512706323 0.956521739130435 27.2 27 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 9.06333324446749e-05 0.000300632242584551 0.664795512706323 0.956521739130435 27.2 27 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 9.06333324446749e-05 0.000300632242584551 0.664795512706323 0.956521739130435 27.2 27 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 9.06333324446749e-05 0.000300632242584551 0.664795512706323 0.956521739130435 27.2 27 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.44441528130431e-08 1.51234910665045e-07 0.664124002087428 0.955555555555556 27.2 27 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.19236910286149e-18 3.85623007584522e-17 0.663421968258583 0.954545454545455 27.2 27 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 3.96835677074911e-08 2.39278461219321e-07 0.663421968258583 0.954545454545455 27.2 27 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000147397781523224 0.000467142634983402 0.663421968258583 0.954545454545455 27.2 27 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000147397781523224 0.000467142634983402 0.663421968258583 0.954545454545455 27.2 27 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.92952899407143e-11 1.76007676831003e-10 0.662935944838613 0.953846153846154 27.2 27 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 9.7975034738177e-15 2.02055760046994e-13 0.662687281693512 0.953488372093023 27.2 27 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 6.4359013443557e-08 3.78441636901577e-07 0.662687281693512 0.953488372093023 27.2 27 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.58728467214402e-14 2.97198169534334e-13 0.662306973353946 0.952941176470588 27.2 27 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.58728467214402e-14 2.97198169534334e-13 0.662306973353946 0.952941176470588 27.2 27 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.58728467214402e-14 2.97198169534334e-13 0.662306973353946 0.952941176470588 27.2 27 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.58728467214402e-14 2.97198169534334e-13 0.662306973353946 0.952941176470588 27.2 27 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.58728467214402e-14 2.97198169534334e-13 0.662306973353946 0.952941176470588 27.2 27 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.04268081110977e-07 6.00702345833688e-07 0.661917610053915 0.952380952380952 27.2 27 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000239273060938594 0.000712312898986651 0.661917610053915 0.952380952380952 27.2 27 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000239273060938594 0.000712312898986651 0.661917610053915 0.952380952380952 27.2 27 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000239273060938594 0.000712312898986651 0.661917610053915 0.952380952380952 27.2 27 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000239273060938594 0.000712312898986651 0.661917610053915 0.952380952380952 27.2 27 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000239273060938594 0.000712312898986651 0.661917610053915 0.952380952380952 27.2 27 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000239273060938594 0.000712312898986651 0.661917610053915 0.952380952380952 27.2 27 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000239273060938594 0.000712312898986651 0.661917610053915 0.952380952380952 27.2 27 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000239273060938594 0.000712312898986651 0.661917610053915 0.952380952380952 27.2 27 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.29946188325154e-43 2.64162037123848e-41 0.661795934022655 0.952205882352941 27.2 27 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 6.72600727668107e-14 1.12601274761378e-12 0.661110393456288 0.951219512195122 27.2 27 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.68739099918179e-07 9.06097128994599e-07 0.661110393456288 0.951219512195122 27.2 27 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.68739099918179e-07 9.06097128994599e-07 0.661110393456288 0.951219512195122 27.2 27 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.68739099918179e-07 9.06097128994599e-07 0.661110393456288 0.951219512195122 27.2 27 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.68739099918179e-07 9.06097128994599e-07 0.661110393456288 0.951219512195122 27.2 27 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.08709250488489e-13 1.79875887726884e-12 0.660691836701963 0.950617283950617 27.2 27 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 2.72759521594351e-07 1.36188350606583e-06 0.66026281602878 0.95 27.2 27 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.000387636227826473 0.00110542355149714 0.66026281602878 0.95 27.2 27 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000387636227826473 0.00110542355149714 0.66026281602878 0.95 27.2 27 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000387636227826473 0.00110542355149714 0.66026281602878 0.95 27.2 27 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 4.40372104548332e-07 2.11705913774418e-06 0.659371773092169 0.948717948717949 27.2 27 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000626614001864198 0.00170818338056083 0.658433833158894 0.947368421052632 27.2 27 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.91138991298214e-12 2.6929780655184e-11 0.657946104393591 0.946666666666667 27.2 27 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.91138991298214e-12 2.6929780655184e-11 0.657946104393591 0.946666666666667 27.2 27 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.91138991298214e-12 2.6929780655184e-11 0.657946104393591 0.946666666666667 27.2 27 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.91138991298214e-12 2.6929780655184e-11 0.657946104393591 0.946666666666667 27.2 27 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.91138991298214e-12 2.6929780655184e-11 0.657946104393591 0.946666666666667 27.2 27 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.44480750238073e-09 1.07081306035822e-08 0.657780624991078 0.946428571428571 27.2 27 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.7223670087741e-34 2.45092825348555e-32 0.657613661468362 0.946188340807175 27.2 27 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.14345927519991e-06 5.14918528040972e-06 0.657445193769767 0.945945945945946 27.2 27 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.14345927519991e-06 5.14918528040972e-06 0.657445193769767 0.945945945945946 27.2 27 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.14345927519991e-06 5.14918528040972e-06 0.657445193769767 0.945945945945946 27.2 27 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.30413051807556e-28 2.04923607951345e-26 0.657034611291222 0.945355191256831 27.2 27 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.37765863777149e-17 6.63413380695849e-16 0.656755867223219 0.944954128440367 27.2 27 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.37765863777149e-17 6.63413380695849e-16 0.656755867223219 0.944954128440367 27.2 27 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 3.73328249679286e-09 2.65623049646812e-08 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.93810840918472e-12 7.79029535604818e-11 0.656401629970132 0.944444444444444 27.2 27 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.83875352828692e-06 7.92064759242459e-06 0.656401629970132 0.944444444444444 27.2 27 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.83875352828692e-06 7.92064759242459e-06 0.656401629970132 0.944444444444444 27.2 27 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 1.83875352828692e-06 7.92064759242459e-06 0.656401629970132 0.944444444444444 27.2 27 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00101047617518357 0.00266773209144011 0.656401629970132 0.944444444444444 27.2 27 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00101047617518357 0.00266773209144011 0.656401629970132 0.944444444444444 27.2 27 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00101047617518357 0.00266773209144011 0.656401629970132 0.944444444444444 27.2 27 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00101047617518357 0.00266773209144011 0.656401629970132 0.944444444444444 27.2 27 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 5.99198245948129e-09 4.041038407508e-08 0.655673104298689 0.943396226415094 27.2 27 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.95246777355998e-06 1.23207086269086e-05 0.655298433953376 0.942857142857143 27.2 27 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 2.95246777355998e-06 1.23207086269086e-05 0.655298433953376 0.942857142857143 27.2 27 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.95246777355998e-06 1.23207086269086e-05 0.655298433953376 0.942857142857143 27.2 27 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 9.60700811457665e-09 6.27099658121219e-08 0.654916558409114 0.942307692307692 27.2 27 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.14293407332924e-13 1.86941975442242e-12 0.654605729477738 0.941860465116279 27.2 27 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.31521972542754e-18 7.16208188974651e-17 0.65413034405328 0.941176470588235 27.2 27 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 4.73336750891597e-06 1.9355120589619e-05 0.65413034405328 0.941176470588235 27.2 27 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 4.73336750891597e-06 1.9355120589619e-05 0.65413034405328 0.941176470588235 27.2 27 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00162514576554714 0.0041076064376085 0.65413034405328 0.941176470588235 27.2 27 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00162514576554714 0.0041076064376085 0.65413034405328 0.941176470588235 27.2 27 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00162514576554714 0.0041076064376085 0.65413034405328 0.941176470588235 27.2 27 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.65717228078938e-15 3.80347767026337e-14 0.653312681123214 0.94 27.2 27 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 2.46131362324601e-08 1.51621181206886e-07 0.653312681123214 0.94 27.2 27 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 5.43891570940274e-20 2.21130772985146e-18 0.652891460825907 0.939393939393939 27.2 27 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.138489363384e-10 1.70959009218844e-09 0.65224342959928 0.938461538461538 27.2 27 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.21282371165148e-19 8.07396959405141e-18 0.651911878739146 0.937984496124031 27.2 27 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 1.21046792684734e-05 4.74516765813709e-05 0.651575147396822 0.9375 27.2 27 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00260597606826029 0.00612754329837552 0.651575147396822 0.9375 27.2 27 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00260597606826029 0.00612754329837552 0.651575147396822 0.9375 27.2 27 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.00260597606826029 0.00612754329837552 0.651575147396822 0.9375 27.2 27 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00260597606826029 0.00612754329837552 0.651575147396822 0.9375 27.2 27 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00260597606826029 0.00612754329837552 0.651575147396822 0.9375 27.2 27 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00260597606826029 0.00612754329837552 0.651575147396822 0.9375 27.2 27 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00260597606826029 0.00612754329837552 0.651575147396822 0.9375 27.2 27 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.02925486404124e-12 3.65307599282261e-11 0.651025294951762 0.936708860759494 27.2 27 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.02925486404124e-12 3.65307599282261e-11 0.651025294951762 0.936708860759494 27.2 27 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 5.43501472232935e-10 4.18055456749982e-09 0.650885649886349 0.936507936507937 27.2 27 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.31067423944833e-20 5.65178619010599e-19 0.650334051877971 0.935714285714286 27.2 27 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.31067423944833e-20 5.65178619010599e-19 0.650334051877971 0.935714285714286 27.2 27 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 4.34308638936154e-14 7.46115179534321e-13 0.6501739105207 0.935483870967742 27.2 27 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.59200902247167e-07 8.69166921244349e-07 0.649686523781179 0.934782608695652 27.2 27 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.59200902247167e-07 8.69166921244349e-07 0.649686523781179 0.934782608695652 27.2 27 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.85416722480325e-22 2.6567230618827e-20 0.649288918809465 0.934210526315789 27.2 27 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.74216528648269e-13 2.78550696928637e-12 0.648679257852836 0.933333333333333 27.2 27 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00416494453252892 0.00933341113352543 0.648679257852836 0.933333333333333 27.2 27 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00416494453252892 0.00933341113352543 0.648679257852836 0.933333333333333 27.2 27 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00416494453252892 0.00933341113352543 0.648679257852836 0.933333333333333 27.2 27 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00416494453252892 0.00933341113352543 0.648679257852836 0.933333333333333 27.2 27 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00416494453252892 0.00933341113352543 0.648679257852836 0.933333333333333 27.2 27 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00416494453252892 0.00933341113352543 0.648679257852836 0.933333333333333 27.2 27 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00416494453252892 0.00933341113352543 0.648679257852836 0.933333333333333 27.2 27 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00416494453252892 0.00933341113352543 0.648679257852836 0.933333333333333 27.2 27 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 4.01590105169793e-07 1.95038470872565e-06 0.647626207109569 0.931818181818182 27.2 27 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 4.01590105169793e-07 1.95038470872565e-06 0.647626207109569 0.931818181818182 27.2 27 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.86817038135751e-11 4.19842815313439e-10 0.647409826819856 0.931506849315068 27.2 27 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 5.49419036002787e-09 3.81408260762239e-08 0.647081525690637 0.931034482758621 27.2 27 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 5.49419036002787e-09 3.81408260762239e-08 0.647081525690637 0.931034482758621 27.2 27 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 4.88058172248817e-05 0.000172334188364781 0.647081525690637 0.931034482758621 27.2 27 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 4.88058172248817e-05 0.000172334188364781 0.647081525690637 0.931034482758621 27.2 27 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 4.88058172248817e-05 0.000172334188364781 0.647081525690637 0.931034482758621 27.2 27 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 4.88058172248817e-05 0.000172334188364781 0.647081525690637 0.931034482758621 27.2 27 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 4.88058172248817e-05 0.000172334188364781 0.647081525690637 0.931034482758621 27.2 27 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.79689178998106e-22 1.11172913788828e-20 0.646930796241373 0.930817610062893 27.2 27 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 7.70839544827509e-11 6.5682914508356e-10 0.646748664823512 0.930555555555556 27.2 27 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 6.36388983343253e-07 2.99861431555447e-06 0.646524177261963 0.930232558139535 27.2 27 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 6.36388983343253e-07 2.99861431555447e-06 0.646524177261963 0.930232558139535 27.2 27 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.50212265184959e-22 2.56260821343279e-20 0.646318277842453 0.929936305732484 27.2 27 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.21935770807102e-10 9.91512010620038e-10 0.646068878545581 0.929577464788732 27.2 27 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.73677288212918e-12 2.57440397007273e-11 0.645953714752614 0.929411764705882 27.2 27 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 5.27027377231719e-18 1.59565948468242e-16 0.645760566028977 0.929133858267717 27.2 27 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.92688248434817e-10 1.54912642668217e-09 0.645369669802567 0.928571428571429 27.2 27 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.0068623444118e-06 4.63678031099673e-06 0.645369669802567 0.928571428571429 27.2 27 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.0068623444118e-06 4.63678031099673e-06 0.645369669802567 0.928571428571429 27.2 27 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 7.73488380691385e-05 0.000259592916444302 0.645369669802567 0.928571428571429 27.2 27 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 7.73488380691385e-05 0.000259592916444302 0.645369669802567 0.928571428571429 27.2 27 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 7.73488380691385e-05 0.000259592916444302 0.645369669802567 0.928571428571429 27.2 27 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 7.73488380691385e-05 0.000259592916444302 0.645369669802567 0.928571428571429 27.2 27 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00663176406878005 0.0140222886625171 0.645369669802567 0.928571428571429 27.2 27 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00663176406878005 0.0140222886625171 0.645369669802567 0.928571428571429 27.2 27 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00663176406878005 0.0140222886625171 0.645369669802567 0.928571428571429 27.2 27 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00663176406878005 0.0140222886625171 0.645369669802567 0.928571428571429 27.2 27 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.00663176406878005 0.0140222886625171 0.645369669802567 0.928571428571429 27.2 27 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00663176406878005 0.0140222886625171 0.645369669802567 0.928571428571429 27.2 27 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.91991303607156e-19 7.18956907981535e-18 0.645012520012969 0.928057553956835 27.2 27 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 4.33140798094962e-12 5.17949038394228e-11 0.644771551480229 0.927710843373494 27.2 27 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 3.04175204786101e-10 2.39138848845647e-09 0.644650194139465 0.927536231884058 27.2 27 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.04175204786101e-10 2.39138848845647e-09 0.644650194139465 0.927536231884058 27.2 27 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 2.17064523150394e-08 1.34883325957647e-07 0.644467054879766 0.927272727272727 27.2 27 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 6.83101871903171e-12 7.7764317097457e-11 0.644158844906127 0.926829268292683 27.2 27 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.59035152949254e-06 6.98478464959222e-06 0.644158844906127 0.926829268292683 27.2 27 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.59035152949254e-06 6.98478464959222e-06 0.644158844906127 0.926829268292683 27.2 27 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.59035152949254e-06 6.98478464959222e-06 0.644158844906127 0.926829268292683 27.2 27 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 1.59035152949254e-06 6.98478464959222e-06 0.644158844906127 0.926829268292683 27.2 27 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.59035152949254e-06 6.98478464959222e-06 0.644158844906127 0.926829268292683 27.2 27 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.07631206674509e-11 1.04189936801242e-10 0.643531009774639 0.925925925925926 27.2 27 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.07631206674509e-11 1.04189936801242e-10 0.643531009774639 0.925925925925926 27.2 27 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000122292932496002 0.000400974292492652 0.643531009774639 0.925925925925926 27.2 27 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000122292932496002 0.000400974292492652 0.643531009774639 0.925925925925926 27.2 27 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000122292932496002 0.000400974292492652 0.643531009774639 0.925925925925926 27.2 27 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.000122292932496002 0.000400974292492652 0.643531009774639 0.925925925925926 27.2 27 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000122292932496002 0.000400974292492652 0.643531009774639 0.925925925925926 27.2 27 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 7.55512639647692e-10 5.68833061491358e-09 0.643146812156863 0.925373134328358 27.2 27 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.50759396098075e-06 1.06199589478441e-05 0.642887478764865 0.925 27.2 27 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 2.50759396098075e-06 1.06199589478441e-05 0.642887478764865 0.925 27.2 27 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.66436028487948e-11 2.35489732011398e-10 0.642227655830792 0.924050632911392 27.2 27 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.000192859232719603 0.000604490502555057 0.641550914359948 0.923076923076923 27.2 27 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000192859232719603 0.000604490502555057 0.641550914359948 0.923076923076923 27.2 27 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000192859232719603 0.000604490502555057 0.641550914359948 0.923076923076923 27.2 27 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000192859232719603 0.000604490502555057 0.641550914359948 0.923076923076923 27.2 27 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0105151187910421 0.0207531401382148 0.641550914359948 0.923076923076923 27.2 27 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0105151187910421 0.0207531401382148 0.641550914359948 0.923076923076923 27.2 27 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0105151187910421 0.0207531401382148 0.641550914359948 0.923076923076923 27.2 27 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0105151187910421 0.0207531401382148 0.641550914359948 0.923076923076923 27.2 27 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0105151187910421 0.0207531401382148 0.641550914359948 0.923076923076923 27.2 27 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0105151187910421 0.0207531401382148 0.641550914359948 0.923076923076923 27.2 27 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0105151187910421 0.0207531401382148 0.641550914359948 0.923076923076923 27.2 27 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0105151187910421 0.0207531401382148 0.641550914359948 0.923076923076923 27.2 27 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.93195401118923e-09 2.10715684743549e-08 0.640715561606875 0.921875 27.2 27 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.33031704061587e-07 7.57216459518555e-07 0.64050262855217 0.92156862745098 27.2 27 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.33031704061587e-07 7.57216459518555e-07 0.64050262855217 0.92156862745098 27.2 27 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 4.40813720407668e-17 1.20630370026944e-15 0.640288018859239 0.921259842519685 27.2 27 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 6.19951055875114e-06 2.50622259235877e-05 0.640144004460036 0.921052631578947 27.2 27 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 4.59618695136699e-09 3.2378089266313e-08 0.639853689718784 0.920634920634921 27.2 27 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000303311541411424 0.000893607294882933 0.639412411312082 0.92 27.2 27 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000303311541411424 0.000893607294882933 0.639412411312082 0.92 27.2 27 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000303311541411424 0.000893607294882933 0.639412411312082 0.92 27.2 27 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 5.71933286901035e-12 6.6579114505402e-11 0.639092864879642 0.919540229885057 27.2 27 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 5.71933286901035e-12 6.6579114505402e-11 0.639092864879642 0.919540229885057 27.2 27 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 4.03509025660548e-33 4.78494452929133e-31 0.638877785550115 0.919230769230769 27.2 27 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.70986364008595e-27 4.06256797992115e-25 0.638750493702028 0.919047619047619 27.2 27 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 8.03172589254746e-21 3.6868212726113e-19 0.638543644448886 0.91875 27.2 27 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.64434338342267e-16 6.48775971484563e-15 0.63850832872274 0.91869918699187 27.2 27 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.91534490476744e-22 1.72855658311836e-20 0.638442625046189 0.918604651162791 27.2 27 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.146295793087e-14 2.330255590804e-13 0.638148750420161 0.918181818181818 27.2 27 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.12507280150183e-08 7.14722587739777e-08 0.638045171658528 0.918032786885246 27.2 27 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.12507280150183e-08 7.14722587739777e-08 0.638045171658528 0.918032786885246 27.2 27 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.12507280150183e-08 7.14722587739777e-08 0.638045171658528 0.918032786885246 27.2 27 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.94242420288555e-10 3.08245584654183e-09 0.637889094072505 0.917808219178082 27.2 27 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.11694324725558e-22 3.75089268179433e-20 0.637777085451948 0.917647058823529 27.2 27 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.11109019740179e-21 5.45200465828536e-20 0.637438408498666 0.917159763313609 27.2 27 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.17932814833289e-11 1.95043016042623e-10 0.637095699676893 0.916666666666667 27.2 27 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.17932814833289e-11 1.95043016042623e-10 0.637095699676893 0.916666666666667 27.2 27 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 6.15305750374967e-10 4.68224643199775e-09 0.637095699676893 0.916666666666667 27.2 27 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.15305750374967e-10 4.68224643199775e-09 0.637095699676893 0.916666666666667 27.2 27 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.75665470526662e-08 1.10607063964354e-07 0.637095699676893 0.916666666666667 27.2 27 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.75665470526662e-08 1.10607063964354e-07 0.637095699676893 0.916666666666667 27.2 27 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 1.52033244715636e-05 5.9110193232336e-05 0.637095699676893 0.916666666666667 27.2 27 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000475614712047499 0.00134019749553186 0.637095699676893 0.916666666666667 27.2 27 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000475614712047499 0.00134019749553186 0.637095699676893 0.916666666666667 27.2 27 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.000475614712047499 0.00134019749553186 0.637095699676893 0.916666666666667 27.2 27 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.000475614712047499 0.00134019749553186 0.637095699676893 0.916666666666667 27.2 27 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0165921353302517 0.0310257668527571 0.637095699676893 0.916666666666667 27.2 27 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0165921353302517 0.0310257668527571 0.637095699676893 0.916666666666667 27.2 27 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.35190160937095e-14 7.46115179534321e-13 0.636554411911662 0.91588785046729 27.2 27 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 2.73889746361663e-08 1.67272579001136e-07 0.636114042204355 0.915254237288136 27.2 27 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.49336940586643e-09 1.10106977437717e-08 0.635440905651758 0.914285714285714 27.2 27 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 2.37296313527134e-05 9.00460411064299e-05 0.635440905651758 0.914285714285714 27.2 27 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.37296313527134e-05 9.00460411064299e-05 0.635440905651758 0.914285714285714 27.2 27 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.59025515744913e-20 6.65568555602975e-19 0.635319080324754 0.914110429447853 27.2 27 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 4.26410649803228e-08 2.54950569189073e-07 0.635098534474144 0.913793103448276 27.2 27 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 4.26410649803228e-08 2.54950569189073e-07 0.635098534474144 0.913793103448276 27.2 27 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.41294719474662e-51 1.21415596453111e-48 0.634648469076341 0.913145539906103 27.2 27 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.23829735304699e-06 5.55866603591756e-06 0.634577534856036 0.91304347826087 27.2 27 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000743424496847983 0.00200358533904295 0.634577534856036 0.91304347826087 27.2 27 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.69499206624113e-05 0.000135514786346936 0.633688770801615 0.911764705882353 27.2 27 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 3.69499206624113e-05 0.000135514786346936 0.633688770801615 0.911764705882353 27.2 27 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.43770704544466e-19 5.5293435828858e-18 0.633430016709822 0.911392405063291 27.2 27 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.02880502166463e-07 5.97546753399499e-07 0.632958714614056 0.910714285714286 27.2 27 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.70355754850533e-11 1.56397573646651e-10 0.632540367809949 0.910112359550562 27.2 27 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 2.98416131948081e-15 6.53301778095568e-14 0.632348339768719 0.909836065573771 27.2 27 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.67973820687386e-16 4.42642123774353e-15 0.63230550644624 0.909774436090226 27.2 27 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.6176491399563e-15 9.80733541217585e-14 0.631830445960555 0.909090909090909 27.2 27 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.6176491399563e-15 9.80733541217585e-14 0.631830445960555 0.909090909090909 27.2 27 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.46933750099843e-12 2.20091290939028e-11 0.631830445960555 0.909090909090909 27.2 27 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.59418528773559e-07 8.69166921244349e-07 0.631830445960555 0.909090909090909 27.2 27 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 1.59418528773559e-07 8.69166921244349e-07 0.631830445960555 0.909090909090909 27.2 27 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.59418528773559e-07 8.69166921244349e-07 0.631830445960555 0.909090909090909 27.2 27 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 1.59418528773559e-07 8.69166921244349e-07 0.631830445960555 0.909090909090909 27.2 27 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.59418528773559e-07 8.69166921244349e-07 0.631830445960555 0.909090909090909 27.2 27 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 1.59418528773559e-07 8.69166921244349e-07 0.631830445960555 0.909090909090909 27.2 27 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 1.59418528773559e-07 8.69166921244349e-07 0.631830445960555 0.909090909090909 27.2 27 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 5.73914264344925e-05 0.000198705595660056 0.631830445960555 0.909090909090909 27.2 27 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 5.73914264344925e-05 0.000198705595660056 0.631830445960555 0.909090909090909 27.2 27 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 8.69999324836221e-44 2.06334839873657e-41 0.631830445960555 0.909090909090909 27.2 27 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 2.63675487231738e-11 2.34506386456727e-10 0.631830445960555 0.909090909090909 27.2 27 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0011580258550923 0.00295847538922144 0.631830445960555 0.909090909090909 27.2 27 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0011580258550923 0.00295847538922144 0.631830445960555 0.909090909090909 27.2 27 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0011580258550923 0.00295847538922144 0.631830445960555 0.909090909090909 27.2 27 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0011580258550923 0.00295847538922144 0.631830445960555 0.909090909090909 27.2 27 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0011580258550923 0.00295847538922144 0.631830445960555 0.909090909090909 27.2 27 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0260357534135285 0.045909389228564 0.631830445960555 0.909090909090909 27.2 27 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 6.20944997365237e-16 1.47267455208455e-14 0.630858399120616 0.907692307692308 27.2 27 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.46611408274308e-07 1.29493739473926e-06 0.630660389579146 0.907407407407407 27.2 27 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.46611408274308e-07 1.29493739473926e-06 0.630660389579146 0.907407407407407 27.2 27 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.54411127838605e-22 4.34223941040834e-20 0.63044939580545 0.907103825136612 27.2 27 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 4.61897761483016e-06 1.90516091185603e-05 0.630361072830414 0.906976744186046 27.2 27 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 3.03085519678994e-13 4.73945818135394e-12 0.63005895872889 0.906542056074766 27.2 27 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 2.06837720397521e-08 1.29092138651611e-07 0.629855975816928 0.90625 27.2 27 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 2.06837720397521e-08 1.29092138651611e-07 0.629855975816928 0.90625 27.2 27 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 9.71216055580214e-11 7.9886731045702e-10 0.629600456151282 0.905882352941176 27.2 27 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 9.71216055580214e-11 7.9886731045702e-10 0.629600456151282 0.905882352941176 27.2 27 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 9.71216055580214e-11 7.9886731045702e-10 0.629600456151282 0.905882352941176 27.2 27 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 9.71216055580214e-11 7.9886731045702e-10 0.629600456151282 0.905882352941176 27.2 27 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 9.71216055580214e-11 7.9886731045702e-10 0.629600456151282 0.905882352941176 27.2 27 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.80828390668293e-07 1.8686855169689e-06 0.629446180126741 0.905660377358491 27.2 27 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 3.80828390668293e-07 1.8686855169689e-06 0.629446180126741 0.905660377358491 27.2 27 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 3.80828390668293e-07 1.8686855169689e-06 0.629446180126741 0.905660377358491 27.2 27 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00179708631326133 0.00433432851486588 0.628821729551219 0.904761904761905 27.2 27 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 5.87028095381068e-07 2.7844699324242e-06 0.628185270310783 0.903846153846154 27.2 27 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 5.87028095381068e-07 2.7844699324242e-06 0.628185270310783 0.903846153846154 27.2 27 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.87018994345413e-28 1.77418685969015e-26 0.628024238454768 0.903614457831325 27.2 27 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.30297173252464e-10 1.83079819853775e-09 0.628024238454768 0.903614457831325 27.2 27 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 4.90968696372275e-08 2.89895624455497e-07 0.627754120502745 0.903225806451613 27.2 27 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 4.90968696372275e-08 2.89895624455497e-07 0.627754120502745 0.903225806451613 27.2 27 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 4.90968696372275e-08 2.89895624455497e-07 0.627754120502745 0.903225806451613 27.2 27 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000137335791852616 0.000437200966009558 0.627754120502745 0.903225806451613 27.2 27 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000137335791852616 0.000437200966009558 0.627754120502745 0.903225806451613 27.2 27 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.09920864522467e-05 4.33289169571942e-05 0.627207296355965 0.902439024390244 27.2 27 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 6.37744696592451e-09 4.28071086439178e-08 0.62649103374117 0.901408450704225 27.2 27 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 5.43409700494688e-10 4.18055456749982e-09 0.626370182847316 0.901234567901235 27.2 27 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.2394214479725e-32 1.35668978497298e-30 0.626223759409369 0.901023890784983 27.2 27 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 6.14834640951484e-12 7.05572333930614e-11 0.625512141500949 0.9 27.2 27 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.000211514369306458 0.000653311581279059 0.625512141500949 0.9 27.2 27 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00277741396820371 0.00642643914919329 0.625512141500949 0.9 27.2 27 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00277741396820371 0.00642643914919329 0.625512141500949 0.9 27.2 27 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00277741396820371 0.00642643914919329 0.625512141500949 0.9 27.2 27 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00277741396820371 0.00642643914919329 0.625512141500949 0.9 27.2 27 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00277741396820371 0.00642643914919329 0.625512141500949 0.9 27.2 27 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00277741396820371 0.00642643914919329 0.625512141500949 0.9 27.2 27 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00277741396820371 0.00642643914919329 0.625512141500949 0.9 27.2 27 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0405894522641871 0.0690894624066247 0.625512141500949 0.9 27.2 27 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.27563356444477e-09 9.50380399060159e-09 0.624632377588852 0.89873417721519 27.2 27 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 7.20826061862995e-20 2.84926523897512e-18 0.624334152533904 0.898305084745763 27.2 27 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.7736786302037e-07 9.48851387511228e-07 0.624334152533904 0.898305084745763 27.2 27 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 2.59123063860339e-05 9.63205792715726e-05 0.623730055627727 0.897435897435897 27.2 27 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 2.59123063860339e-05 9.63205792715726e-05 0.623730055627727 0.897435897435897 27.2 27 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.72058274517448e-28 2.27728779199017e-26 0.623115543257651 0.896551724137931 27.2 27 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 3.25000536205216e-06 1.35226831292404e-05 0.622616251956963 0.895833333333333 27.2 27 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.7007495471355e-55 1.28105553519127e-52 0.622340977285482 0.895437262357414 27.2 27 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 4.42194005854777e-12 5.2436839194279e-11 0.62220255345068 0.895238095238095 27.2 27 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 4.54119814670389e-09 3.21498754366151e-08 0.621854175761178 0.894736842105263 27.2 27 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 3.96323333517091e-05 0.000143503334248046 0.621854175761178 0.894736842105263 27.2 27 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.96323333517091e-05 0.000143503334248046 0.621854175761178 0.894736842105263 27.2 27 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00427330464839824 0.00954617349241867 0.621854175761178 0.894736842105263 27.2 27 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00427330464839824 0.00954617349241867 0.621854175761178 0.894736842105263 27.2 27 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.95899184671571e-06 2.02196143205629e-05 0.621075885178248 0.893617021276596 27.2 27 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000496827052719864 0.00139720335181891 0.620547759425545 0.892857142857143 27.2 27 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.05110822442816e-08 6.7679954903225e-08 0.619876896982923 0.891891891891892 27.2 27 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.05110822442816e-08 6.7679954903225e-08 0.619876896982923 0.891891891891892 27.2 27 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 6.04510220899599e-05 0.000208285240760322 0.619876896982923 0.891891891891892 27.2 27 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.79652252512328e-10 1.45252929161956e-09 0.619468545930892 0.891304347826087 27.2 27 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 8.43364163081272e-17 2.26435321521632e-15 0.619274840944672 0.891025641025641 27.2 27 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.13346612175348e-23 2.67360104147964e-21 0.619193837041344 0.890909090909091 27.2 27 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 1.86736156377281e-07 9.95226780992025e-07 0.617789769383654 0.888888888888889 27.2 27 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000757389634508421 0.00202969011281635 0.617789769383654 0.888888888888889 27.2 27 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000757389634508421 0.00202969011281635 0.617789769383654 0.888888888888889 27.2 27 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000757389634508421 0.00202969011281635 0.617789769383654 0.888888888888889 27.2 27 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00654250248845572 0.0139579925653261 0.617789769383654 0.888888888888889 27.2 27 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00654250248845572 0.0139579925653261 0.617789769383654 0.888888888888889 27.2 27 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00654250248845572 0.0139579925653261 0.617789769383654 0.888888888888889 27.2 27 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00654250248845572 0.0139579925653261 0.617789769383654 0.888888888888889 27.2 27 2 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0627936274385904 0.100512184302716 0.617789769383654 0.888888888888889 27.2 27 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0627936274385904 0.100512184302716 0.617789769383654 0.888888888888889 27.2 27 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0627936274385904 0.100512184302716 0.617789769383654 0.888888888888889 27.2 27 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0627936274385904 0.100512184302716 0.617789769383654 0.888888888888889 27.2 27 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0627936274385904 0.100512184302716 0.617789769383654 0.888888888888889 27.2 27 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0627936274385904 0.100512184302716 0.617789769383654 0.888888888888889 27.2 27 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0627936274385904 0.100512184302716 0.617789769383654 0.888888888888889 27.2 27 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0627936274385904 0.100512184302716 0.617789769383654 0.888888888888889 27.2 27 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.5941085159902e-21 1.23047213941802e-19 0.615583377350141 0.885714285714286 27.2 27 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.71577059030986e-11 3.2438905214791e-10 0.614819626261617 0.884615384615385 27.2 27 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.71577059030986e-11 3.2438905214791e-10 0.614819626261617 0.884615384615385 27.2 27 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00115011257471537 0.00295847538922144 0.614819626261617 0.884615384615385 27.2 27 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00996220333860888 0.020051223975729 0.61324719754995 0.882352941176471 27.2 27 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00996220333860888 0.020051223975729 0.61324719754995 0.882352941176471 27.2 27 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00996220333860888 0.020051223975729 0.61324719754995 0.882352941176471 27.2 27 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00996220333860888 0.020051223975729 0.61324719754995 0.882352941176471 27.2 27 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00996220333860888 0.020051223975729 0.61324719754995 0.882352941176471 27.2 27 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00996220333860888 0.020051223975729 0.61324719754995 0.882352941176471 27.2 27 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00996220333860888 0.020051223975729 0.61324719754995 0.882352941176471 27.2 27 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00996220333860888 0.020051223975729 0.61324719754995 0.882352941176471 27.2 27 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.12552359665616e-18 3.72469785591098e-17 0.61324719754995 0.882352941176471 27.2 27 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.76749790131395e-14 3.26642793970097e-13 0.612389509161769 0.881118881118881 27.2 27 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00173917129671207 0.00428967390488089 0.611611871689817 0.88 27.2 27 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00173917129671207 0.00428967390488089 0.611611871689817 0.88 27.2 27 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00173917129671207 0.00428967390488089 0.611611871689817 0.88 27.2 27 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00173917129671207 0.00428967390488089 0.611611871689817 0.88 27.2 27 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00173917129671207 0.00428967390488089 0.611611871689817 0.88 27.2 27 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.000317380069962743 0.000931199669189655 0.610769431095203 0.878787878787879 27.2 27 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 5.94193510025056e-05 0.000205227515719819 0.610255747805804 0.878048780487805 27.2 27 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 2.17795806970932e-06 9.27914471016875e-06 0.609660956628606 0.87719298245614 27.2 27 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 6.33430844789186e-10 4.79453240497346e-09 0.609032440178473 0.876288659793814 27.2 27 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00261809299045138 0.00612754329837552 0.608136804237034 0.875 27.2 27 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00261809299045138 0.00612754329837552 0.608136804237034 0.875 27.2 27 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00261809299045138 0.00612754329837552 0.608136804237034 0.875 27.2 27 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00261809299045138 0.00612754329837552 0.608136804237034 0.875 27.2 27 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0150777237824093 0.0283055421403277 0.608136804237034 0.875 27.2 27 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0150777237824093 0.0283055421403277 0.608136804237034 0.875 27.2 27 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0150777237824093 0.0283055421403277 0.608136804237034 0.875 27.2 27 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0150777237824093 0.0283055421403277 0.608136804237034 0.875 27.2 27 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0150777237824093 0.0283055421403277 0.608136804237034 0.875 27.2 27 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0150777237824093 0.0283055421403277 0.608136804237034 0.875 27.2 27 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0150777237824093 0.0283055421403277 0.608136804237034 0.875 27.2 27 2 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0962510107339877 0.143119318991081 0.608136804237034 0.875 27.2 27 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.61013007767473e-08 2.19539106860305e-07 0.607037099346913 0.873417721518987 27.2 27 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.000132928516718301 0.000426029908311132 0.605909196895506 0.871794871794872 27.2 27 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.000712219767119896 0.00192312851728959 0.60533433048479 0.870967741935484 27.2 27 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.000712219767119896 0.00192312851728959 0.60533433048479 0.870967741935484 27.2 27 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.000712219767119896 0.00192312851728959 0.60533433048479 0.870967741935484 27.2 27 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.80997193518483e-17 5.25630625258779e-16 0.604516942307052 0.869791666666667 27.2 27 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 4.0605678906305e-07 1.9653701048868e-06 0.604359557005748 0.869565217391304 27.2 27 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 3.75711223355174e-05 0.00013708642841908 0.604359557005748 0.869565217391304 27.2 27 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 3.75711223355174e-05 0.00013708642841908 0.604359557005748 0.869565217391304 27.2 27 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00392203491005437 0.00890120522648704 0.604359557005748 0.869565217391304 27.2 27 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.93790377910425e-11 6.72359349861033e-10 0.60356434706232 0.868421052631579 27.2 27 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.18134949694622e-07 6.77846908933256e-07 0.60356434706232 0.868421052631579 27.2 27 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00106056923990324 0.00273900186639259 0.602345025149062 0.866666666666667 27.2 27 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00106056923990324 0.00273900186639259 0.602345025149062 0.866666666666667 27.2 27 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0226660910544124 0.0419971973573293 0.602345025149062 0.866666666666667 27.2 27 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0226660910544124 0.0419971973573293 0.602345025149062 0.866666666666667 27.2 27 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 4.08748071470758e-16 9.8584492492015e-15 0.600582309774462 0.864130434782609 27.2 27 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.80138575119239e-07 1.8686855169689e-06 0.599806163083102 0.863013698630137 27.2 27 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 4.79063464669721e-11 4.15675189161593e-10 0.59895471543903 0.861788617886179 27.2 27 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 8.79660105821934e-19 3.05306422093808e-17 0.598397265411969 0.860986547085202 27.2 27 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 3.44692585525512e-05 0.00012707190393855 0.597711601878685 0.86 27.2 27 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.35381857012469e-42 2.40810478160929e-40 0.597399236264952 0.859550561797753 27.2 27 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.93839862720464e-09 4.02397202214867e-08 0.596728754518302 0.858585858585859 27.2 27 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 5.05906865879428e-05 0.000178194423303571 0.595725849048523 0.857142857142857 27.2 27 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00865937989785802 0.0176284658006466 0.595725849048523 0.857142857142857 27.2 27 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.00232076512523976 0.00556905358046574 0.595725849048523 0.857142857142857 27.2 27 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0338152471246142 0.0587534757732919 0.595725849048523 0.857142857142857 27.2 27 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0338152471246142 0.0587534757732919 0.595725849048523 0.857142857142857 27.2 27 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0338152471246142 0.0587534757732919 0.595725849048523 0.857142857142857 27.2 27 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0338152471246142 0.0587534757732919 0.595725849048523 0.857142857142857 27.2 27 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0338152471246142 0.0587534757732919 0.595725849048523 0.857142857142857 27.2 27 2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.145876062481581 0.201927662365068 0.595725849048523 0.857142857142857 27.2 27 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 5.09260654635262e-07 2.43180507230194e-06 0.59441943271289 0.855263157894737 27.2 27 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.75498547659875e-06 7.67643464849862e-06 0.594286897722319 0.855072463768116 27.2 27 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 7.40271847761643e-05 0.000253207630746738 0.593657356517105 0.854166666666667 27.2 27 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000936108701341054 0.00249453685769348 0.592805624298285 0.852941176470588 27.2 27 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000936108701341054 0.00249453685769348 0.592805624298285 0.852941176470588 27.2 27 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00340826948090532 0.00774755187113143 0.592048528992668 0.851851851851852 27.2 27 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 3.90382481434604e-08 2.36389051524017e-07 0.591500843026902 0.851063829787234 27.2 27 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.72088731000001e-06 1.53919262852617e-05 0.591280133757116 0.850746268656716 27.2 27 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000381780288686164 0.00109530917500083 0.590761466973119 0.85 27.2 27 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000381780288686164 0.00109530917500083 0.590761466973119 0.85 27.2 27 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0127500185028339 0.0249563635894535 0.590761466973119 0.85 27.2 27 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00136658111299498 0.00347879235025378 0.589708416229851 0.848484848484849 27.2 27 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00136658111299498 0.00347879235025378 0.589708416229851 0.848484848484849 27.2 27 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000156984215943971 0.000496418976196158 0.589250568080604 0.847826086956522 27.2 27 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 6.49586794823165e-05 0.0002232758475926 0.588088338163286 0.846153846153846 27.2 27 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0049789942676939 0.0110034502219482 0.588088338163286 0.846153846153846 27.2 27 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0049789942676939 0.0110034502219482 0.588088338163286 0.846153846153846 27.2 27 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0500157262959046 0.0814329273673596 0.588088338163286 0.846153846153846 27.2 27 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0500157262959046 0.0814329273673596 0.588088338163286 0.846153846153846 27.2 27 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0500157262959046 0.0814329273673596 0.588088338163286 0.846153846153846 27.2 27 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0500157262959046 0.0814329273673596 0.588088338163286 0.846153846153846 27.2 27 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.0500157262959046 0.0814329273673596 0.588088338163286 0.846153846153846 27.2 27 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0500157262959046 0.0814329273673596 0.588088338163286 0.846153846153846 27.2 27 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 1.12796800334545e-05 4.43397367060934e-05 0.58641763265714 0.84375 27.2 27 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.00198591691474214 0.00478165781671416 0.58641763265714 0.84375 27.2 27 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 1.03895710323298e-07 6.00702345833688e-07 0.585274518363461 0.842105263157895 27.2 27 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.54027838685926e-60 1.80740807225037e-57 0.584943480739953 0.841628959276018 27.2 27 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00013522818377375 0.000432426304516958 0.583811332067553 0.84 27.2 27 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00723243188258279 0.0152019949319281 0.583811332067553 0.84 27.2 27 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00723243188258279 0.0152019949319281 0.583811332067553 0.84 27.2 27 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00723243188258279 0.0152019949319281 0.583811332067553 0.84 27.2 27 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.01413906099996e-11 1.82555406611652e-10 0.582914540466834 0.838709677419355 27.2 27 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00287198649837667 0.00663447530387988 0.582914540466834 0.838709677419355 27.2 27 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.70741316227875e-33 3.50240811811152e-31 0.582688077941401 0.838383838383838 27.2 27 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.38779577734663e-50 6.79566678232852e-48 0.580216127839834 0.8348271446863 27.2 27 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 2.53010451834348e-09 1.83690751510346e-08 0.580089999992132 0.834645669291339 27.2 27 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.38470749008944e-14 4.24179844799659e-13 0.579177908797175 0.833333333333333 27.2 27 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 8.32510271376331e-06 3.33707638357329e-05 0.579177908797175 0.833333333333333 27.2 27 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000277737804316513 0.000825095815328598 0.579177908797175 0.833333333333333 27.2 27 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000676567908473419 0.00183732086594976 0.579177908797175 0.833333333333333 27.2 27 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0104417445080694 0.0207531401382148 0.579177908797175 0.833333333333333 27.2 27 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0104417445080694 0.0207531401382148 0.579177908797175 0.833333333333333 27.2 27 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0104417445080694 0.0207531401382148 0.579177908797175 0.833333333333333 27.2 27 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0270607075893746 0.0474813648578052 0.579177908797175 0.833333333333333 27.2 27 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0270607075893746 0.0474813648578052 0.579177908797175 0.833333333333333 27.2 27 2 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0270607075893746 0.0474813648578052 0.579177908797175 0.833333333333333 27.2 27 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0270607075893746 0.0474813648578052 0.579177908797175 0.833333333333333 27.2 27 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0732538438299129 0.111845729366916 0.579177908797175 0.833333333333333 27.2 27 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0732538438299129 0.111845729366916 0.579177908797175 0.833333333333333 27.2 27 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0732538438299129 0.111845729366916 0.579177908797175 0.833333333333333 27.2 27 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0732538438299129 0.111845729366916 0.579177908797175 0.833333333333333 27.2 27 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0732538438299129 0.111845729366916 0.579177908797175 0.833333333333333 27.2 27 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 48%5605140 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 KLOTHO-MEDIATED LIGAND BINDING%REACTOME%REACT_222862.1 KLOTHO-MEDIATED LIGAND BINDING 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 48%5604843 TRAIL SIGNALING 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME DATABASE ID RELEASE 48%5605065 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.217977882953361 0.279443718416786 0.579177908797175 0.833333333333333 27.2 27 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.15704141554204e-11 6.13522285199778e-10 0.578430582463243 0.832258064516129 27.2 27 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 7.24006442948727e-09 4.79191241077227e-08 0.577309592962346 0.830645161290323 27.2 27 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 7.24006442948727e-09 4.79191241077227e-08 0.577309592962346 0.830645161290323 27.2 27 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 7.24006442948727e-09 4.79191241077227e-08 0.577309592962346 0.830645161290323 27.2 27 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.1567427062231e-16 5.38428924729029e-15 0.576419918755284 0.829365079365079 27.2 27 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.1567427062231e-16 5.38428924729029e-15 0.576419918755284 0.829365079365079 27.2 27 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.1567427062231e-16 5.38428924729029e-15 0.576419918755284 0.829365079365079 27.2 27 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000965289578775235 0.00256748985158347 0.576352650705482 0.829268292682927 27.2 27 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.00237466646202131 0.00567924432849803 0.575868320746906 0.828571428571429 27.2 27 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00237466646202131 0.00567924432849803 0.575868320746906 0.828571428571429 27.2 27 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0002320387990005 0.000704032432788298 0.57472269411412 0.826923076923077 27.2 27 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0149760321634831 0.0283055421403277 0.574141579155461 0.826086956521739 27.2 27 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0013713017733655 0.00348457575624841 0.573386129709204 0.825 27.2 27 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0389501525201445 0.0671831115589887 0.57236405104662 0.823529411764706 27.2 27 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0389501525201445 0.0671831115589887 0.57236405104662 0.823529411764706 27.2 27 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 5.23469733652326e-88 7.4489743098726e-85 0.570278984181699 0.820529373789542 27.2 27 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.77041950316755e-32 1.79950496643387e-30 0.569643281226784 0.819614711033275 27.2 27 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 2.7887726242726e-15 6.20066163178112e-14 0.569638507946398 0.819607843137255 27.2 27 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 2.61151725881821e-07 1.30851727440081e-06 0.568647401364499 0.818181818181818 27.2 27 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00477292802260433 0.0106289148296807 0.568647401364499 0.818181818181818 27.2 27 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0213264779707258 0.0396182482406564 0.568647401364499 0.818181818181818 27.2 27 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.106081097092151 0.155622063053743 0.568647401364499 0.818181818181818 27.2 27 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000649286987986357 0.00176660685259003 0.567357951474784 0.816326530612245 27.2 27 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 2.29129148313628e-05 8.74130772252794e-05 0.566984689664603 0.815789473684211 27.2 27 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 5.07354913815681e-07 2.43086209548725e-06 0.566307288601683 0.814814814814815 27.2 27 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0118901833295637 0.0233054144324644 0.566307288601683 0.814814814814815 27.2 27 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0118901833295637 0.0233054144324644 0.566307288601683 0.814814814814815 27.2 27 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0118901833295637 0.0233054144324644 0.566307288601683 0.814814814814815 27.2 27 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0118901833295637 0.0233054144324644 0.566307288601683 0.814814814814815 27.2 27 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 7.6607990642886e-08 4.48613871130974e-07 0.566099697953368 0.814516129032258 27.2 27 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000907855458684458 0.00242834270245861 0.564698461077246 0.8125 27.2 27 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0555490158997597 0.090235444777806 0.564698461077246 0.8125 27.2 27 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0555490158997597 0.090235444777806 0.564698461077246 0.8125 27.2 27 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 4.1831790075199e-07 2.01785211108502e-06 0.564698461077246 0.8125 27.2 27 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 2.04053642946014e-07 1.08346393250813e-06 0.562903488219403 0.809917355371901 27.2 27 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0301352325739813 0.0526811252491098 0.562629968545827 0.80952380952381 27.2 27 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.54274281593811e-08 1.55962199443101e-07 0.561925800875557 0.808510638297872 27.2 27 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0166968698651161 0.0311806375565094 0.561357050064955 0.807692307692308 27.2 27 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.03505359670849e-10 8.46483487423093e-10 0.561078599147264 0.807291666666667 27.2 27 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.000342350098014096 0.00100239545159271 0.558289525201212 0.80327868852459 27.2 27 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00241887740465646 0.00577527272957407 0.556010792445288 0.8 27.2 27 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0130342646993143 0.025373130871579 0.556010792445288 0.8 27.2 27 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0130342646993143 0.025373130871579 0.556010792445288 0.8 27.2 27 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0130342646993143 0.025373130871579 0.556010792445288 0.8 27.2 27 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0130342646993143 0.025373130871579 0.556010792445288 0.8 27.2 27 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0232789950100159 0.0430767358897954 0.556010792445288 0.8 27.2 27 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0422243808324761 0.0695431642645989 0.556010792445288 0.8 27.2 27 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0422243808324761 0.0695431642645989 0.556010792445288 0.8 27.2 27 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.151610328136204 0.208445890761177 0.556010792445288 0.8 27.2 27 2 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.151610328136204 0.208445890761177 0.556010792445288 0.8 27.2 27 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.151610328136204 0.208445890761177 0.556010792445288 0.8 27.2 27 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.151610328136204 0.208445890761177 0.556010792445288 0.8 27.2 27 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.151610328136204 0.208445890761177 0.556010792445288 0.8 27.2 27 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.02120260247015e-08 6.63548540326496e-08 0.55516321501778 0.798780487804878 27.2 27 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.00579191665659312 0.0124499960760302 0.552446620698844 0.794871794871795 27.2 27 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.010163191264184 0.0203693255900476 0.551922477794955 0.794117647058823 27.2 27 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.010163191264184 0.0203693255900476 0.551922477794955 0.794117647058823 27.2 27 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.010163191264184 0.0203693255900476 0.551922477794955 0.794117647058823 27.2 27 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.72145659225112e-06 1.9355120589619e-05 0.551001686207042 0.792792792792793 27.2 27 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00454189935805585 0.0101302864992374 0.549545550672669 0.790697674418605 27.2 27 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.09019269318351e-05 0.000114216732529874 0.548694860965745 0.789473684210526 27.2 27 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0586200199166705 0.0948990766114017 0.548694860965745 0.789473684210526 27.2 27 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0586200199166705 0.0948990766114017 0.548694860965745 0.789473684210526 27.2 27 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0586200199166705 0.0948990766114017 0.548694860965745 0.789473684210526 27.2 27 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.86795517923485e-27 2.89689485265852e-25 0.548012192398447 0.788491446345257 27.2 27 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.79149932798796e-41 4.41367060414097e-39 0.547523140208261 0.787787787787788 27.2 27 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.26575982826823e-06 1.35486187627571e-05 0.546895861421595 0.786885245901639 27.2 27 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.109417483257303 0.159807018502803 0.546082028294479 0.785714285714286 27.2 27 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.109417483257303 0.159807018502803 0.546082028294479 0.785714285714286 27.2 27 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.08528090063527e-14 8.6147080019095e-13 0.54577746497697 0.785276073619632 27.2 27 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.000588052690900356 0.00164400585294933 0.543923601305173 0.782608695652174 27.2 27 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00481746228943356 0.0107113263091624 0.543923601305173 0.782608695652174 27.2 27 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0441880828767998 0.0726932276690014 0.543923601305173 0.782608695652174 27.2 27 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0189209154730204 0.0352876313474548 0.542979289497352 0.78125 27.2 27 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00835424621758302 0.0175340595392635 0.542449553605159 0.780487804878049 27.2 27 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 9.66463356397601e-18 2.86516115865372e-16 0.542297521779597 0.780269058295964 27.2 27 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 7.97204628780806e-05 0.000266296287970678 0.541378929486202 0.778947368421053 27.2 27 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 7.97204628780806e-05 0.000266296287970678 0.541378929486202 0.778947368421053 27.2 27 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000288102070288054 0.000854102595874793 0.540566048210697 0.777777777777778 27.2 27 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00293564350269636 0.0067705359875801 0.540566048210697 0.777777777777778 27.2 27 2 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.213351852267878 0.276754499341103 0.540566048210697 0.777777777777778 27.2 27 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.213351852267878 0.276754499341103 0.540566048210697 0.777777777777778 27.2 27 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.213351852267878 0.276754499341103 0.540566048210697 0.777777777777778 27.2 27 2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.213351852267878 0.276754499341103 0.540566048210697 0.777777777777778 27.2 27 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.213351852267878 0.276754499341103 0.540566048210697 0.777777777777778 27.2 27 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.213351852267878 0.276754499341103 0.540566048210697 0.777777777777778 27.2 27 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.213351852267878 0.276754499341103 0.540566048210697 0.777777777777778 27.2 27 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00648623099149084 0.0139214279048137 0.540566048210697 0.777777777777778 27.2 27 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.11931711687145e-18 3.72469785591098e-17 0.539624295513466 0.776422764227642 27.2 27 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.94191739433205e-05 0.000143461597241292 0.539122614170081 0.775700934579439 27.2 27 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000237519248164662 0.000712312898986651 0.537055879066472 0.772727272727273 27.2 27 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0600849982250501 0.0971601732661889 0.537055879066472 0.772727272727273 27.2 27 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 9.61767858179307e-06 3.80165461719209e-05 0.535850095772654 0.770992366412214 27.2 27 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 9.61767858179307e-06 3.80165461719209e-05 0.535850095772654 0.770992366412214 27.2 27 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.35804457432403e-06 6.07308061194328e-06 0.535647339855732 0.770700636942675 27.2 27 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000314224378370723 0.000923845641366816 0.5352402743367 0.770114942528736 27.2 27 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0452194121596817 0.0742182508687739 0.534625761966623 0.769230769230769 27.2 27 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.15071423560994 0.208219764342665 0.534625761966623 0.769230769230769 27.2 27 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.15071423560994 0.208219764342665 0.534625761966623 0.769230769230769 27.2 27 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.000414425470107189 0.00117945488792506 0.53338244624112 0.767441860465116 27.2 27 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0342625862491622 0.0593134552707516 0.532843676093401 0.766666666666667 27.2 27 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0342625862491622 0.0593134552707516 0.532843676093401 0.766666666666667 27.2 27 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 5.34071555303173e-10 4.15291706664708e-09 0.531923682303254 0.765342960288809 27.2 27 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.00054486267788456 0.00152625903667269 0.53148090454329 0.764705882352941 27.2 27 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.00054486267788456 0.00152625903667269 0.53148090454329 0.764705882352941 27.2 27 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.109495321883509 0.159807018502803 0.53148090454329 0.764705882352941 27.2 27 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00535603691071178 0.0115304697790361 0.530737574606866 0.763636363636364 27.2 27 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0199626904257572 0.0371332136939248 0.530405032266887 0.763157894736842 27.2 27 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.015323028128176 0.028728154184973 0.529534088043132 0.761904761904762 27.2 27 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0455807120889535 0.0747250614085033 0.527251613525704 0.758620689655172 27.2 27 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0345722690411834 0.0597768394235772 0.526525371633796 0.757575757575758 27.2 27 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00256010796440937 0.00610223389171614 0.526224499992862 0.757142857142857 27.2 27 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 1.36142847168651e-06 6.07308061194328e-06 0.525956155015813 0.756756756756757 27.2 27 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.000464713400683822 0.00131993446940734 0.521260117917458 0.75 27.2 27 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.107806937169253 0.157991010908185 0.521260117917458 0.75 27.2 27 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.204562856878865 0.268306286621419 0.521260117917458 0.75 27.2 27 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.204562856878865 0.268306286621419 0.521260117917458 0.75 27.2 27 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.204562856878865 0.268306286621419 0.521260117917458 0.75 27.2 27 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.204562856878865 0.268306286621419 0.521260117917458 0.75 27.2 27 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.204562856878865 0.268306286621419 0.521260117917458 0.75 27.2 27 2 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.294751217724363 0.371177860904219 0.521260117917458 0.75 27.2 27 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.294751217724363 0.371177860904219 0.521260117917458 0.75 27.2 27 2 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.294751217724363 0.371177860904219 0.521260117917458 0.75 27.2 27 2 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.294751217724363 0.371177860904219 0.521260117917458 0.75 27.2 27 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 1.43134048590985e-07 8.11473112131359e-07 0.51785318904218 0.745098039215686 27.2 27 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0449808369093181 0.073911929471085 0.516295735842053 0.742857142857143 27.2 27 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.105126258378426 0.155622063053743 0.513705623454886 0.739130434782609 27.2 27 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 5.34102952411164e-05 0.000187661358341009 0.512784343642377 0.73780487804878 27.2 27 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.194682915849977 0.265867360129095 0.509676559741514 0.733333333333333 27.2 27 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.194682915849977 0.265867360129095 0.509676559741514 0.733333333333333 27.2 27 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0112619232228111 0.0221962835818008 0.506366971691245 0.728571428571429 27.2 27 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0067293843806546 0.0142075874980289 0.50624439435605 0.728395061728395 27.2 27 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0744828291604198 0.113600284989579 0.505464356768444 0.727272727272727 27.2 27 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.273021610920345 0.345035304031661 0.505464356768444 0.727272727272727 27.2 27 2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.273021610920345 0.345035304031661 0.505464356768444 0.727272727272727 27.2 27 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.273021610920345 0.345035304031661 0.505464356768444 0.727272727272727 27.2 27 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.273021610920345 0.345035304031661 0.505464356768444 0.727272727272727 27.2 27 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.273021610920345 0.345035304031661 0.505464356768444 0.727272727272727 27.2 27 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.273021610920345 0.345035304031661 0.505464356768444 0.727272727272727 27.2 27 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.273021610920345 0.345035304031661 0.505464356768444 0.727272727272727 27.2 27 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.184718813358251 0.252988326668711 0.501954187624219 0.722222222222222 27.2 27 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0233510242131302 0.0431539057860834 0.501321206303129 0.721311475409836 27.2 27 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.130680316448946 0.18284964631942 0.500409713200759 0.72 27.2 27 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.124916314182853 0.174956609332874 0.496438207540436 0.714285714285714 27.2 27 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.253956116491535 0.323237525731175 0.496438207540436 0.714285714285714 27.2 27 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.253956116491535 0.323237525731175 0.496438207540436 0.714285714285714 27.2 27 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.253956116491535 0.323237525731175 0.496438207540436 0.714285714285714 27.2 27 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.253956116491535 0.323237525731175 0.496438207540436 0.714285714285714 27.2 27 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.253956116491535 0.323237525731175 0.496438207540436 0.714285714285714 27.2 27 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.253956116491535 0.323237525731175 0.496438207540436 0.714285714285714 27.2 27 2 HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%REACT_198593.2 HIGHLY SODIUM PERMEABLE ACETYLCHOLINE NICOTINIC RECEPTORS 0.398232434132809 0.467561678028867 0.496438207540436 0.714285714285714 27.2 27 2 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.398232434132809 0.467561678028867 0.496438207540436 0.714285714285714 27.2 27 2 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_225157.1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE 0.398232434132809 0.467561678028867 0.496438207540436 0.714285714285714 27.2 27 2 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_216831.1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE 0.398232434132809 0.467561678028867 0.496438207540436 0.714285714285714 27.2 27 2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.398232434132809 0.467561678028867 0.496438207540436 0.714285714285714 27.2 27 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0273275401839721 0.0478905045342269 0.494933849335768 0.712121212121212 27.2 27 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000199259457835665 0.000623178480220114 0.489194044855297 0.703862660944206 27.2 27 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0150685540414633 0.0283055421403277 0.486509443389627 0.7 27.2 27 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.357415408575118 0.422427015284379 0.486509443389627 0.7 27.2 27 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0196705491483812 0.0366376851284639 0.485762117055695 0.698924731182796 27.2 27 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0895307201597137 0.135390238881267 0.482254258753566 0.693877551020408 27.2 27 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0297784945108224 0.0521215223725711 0.481770715044923 0.693181818181818 27.2 27 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.195464159138488 0.266678330253181 0.481163185769961 0.692307692307692 27.2 27 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0813430715229905 0.123402122363769 0.480191138930022 0.690909090909091 27.2 27 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00225676381514076 0.00542461977862383 0.479806267592381 0.690355329949239 27.2 27 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0775466116386368 0.117768226640107 0.479319648659731 0.689655172413793 27.2 27 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0775466116386368 0.117768226640107 0.479319648659731 0.689655172413793 27.2 27 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0775466116386368 0.117768226640107 0.479319648659731 0.689655172413793 27.2 27 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0341999664581118 0.0593134552707516 0.478787071272332 0.688888888888889 27.2 27 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.108628425868892 0.159031121410939 0.47782177475767 0.6875 27.2 27 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.173364653085935 0.237666571619736 0.47782177475767 0.6875 27.2 27 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.299584367290632 0.376597663122411 0.47782177475767 0.6875 27.2 27 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.299584367290632 0.376597663122411 0.47782177475767 0.6875 27.2 27 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.210980857885681 0.275436477771858 0.470815590377059 0.67741935483871 27.2 27 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.156579825848579 0.215070552299737 0.468378656679455 0.673913043478261 27.2 27 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0874545580551305 0.132391315013245 0.466274873411397 0.670886075949367 27.2 27 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.409939119003303 0.480513481335833 0.46334232703774 0.666666666666667 27.2 27 2 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.457549948637332 0.523402030641609 0.46334232703774 0.666666666666667 27.2 27 2 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.457549948637332 0.523402030641609 0.46334232703774 0.666666666666667 27.2 27 2 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.457549948637332 0.523402030641609 0.46334232703774 0.666666666666667 27.2 27 2 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.457549948637332 0.523402030641609 0.46334232703774 0.666666666666667 27.2 27 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.185932160462358 0.254405254171092 0.46334232703774 0.666666666666667 27.2 27 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0622671778566269 0.100512184302716 0.453269667754311 0.652173913043478 27.2 27 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.075631220948183 0.115228294870733 0.450471706842248 0.648148148148148 27.2 27 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.262802535694413 0.334198398832126 0.448862879317811 0.645833333333333 27.2 27 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.454901303570288 0.523402030641609 0.446794386786392 0.642857142857143 27.2 27 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.454901303570288 0.523402030641609 0.446794386786392 0.642857142857143 27.2 27 2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.454901303570288 0.523402030641609 0.446794386786392 0.642857142857143 27.2 27 2 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.454901303570288 0.523402030641609 0.446794386786392 0.642857142857143 27.2 27 2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.454901303570288 0.523402030641609 0.446794386786392 0.642857142857143 27.2 27 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.454901303570288 0.523402030641609 0.446794386786392 0.642857142857143 27.2 27 2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.454901303570288 0.523402030641609 0.446794386786392 0.642857142857143 27.2 27 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.120385666559921 0.169821562027619 0.443444190293788 0.638036809815951 27.2 27 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.505104554470971 0.575932516836692 0.442281312172388 0.636363636363636 27.2 27 2 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.505104554470971 0.575932516836692 0.442281312172388 0.636363636363636 27.2 27 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.160823142186482 0.220685951139213 0.439427884351921 0.632258064516129 27.2 27 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.0832427852750248 0.126149609634037 0.439347813673286 0.632142857142857 27.2 27 2 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 48%5605118 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS 0.570701128146886 0.644529924883348 0.434383431597882 0.625 27.2 27 2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.570701128146886 0.644529924883348 0.434383431597882 0.625 27.2 27 2 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 48%5605104 DISSOLUTION OF FIBRIN CLOT 0.570701128146886 0.644529924883348 0.434383431597882 0.625 27.2 27 2 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%REACT_208465.1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 0.570701128146886 0.644529924883348 0.434383431597882 0.625 27.2 27 2 EARLY STAGE PANCREATIC PRECURSOR CELLS%REACTOME%REACT_13403.1 EARLY STAGE PANCREATIC PRECURSOR CELLS 0.570701128146886 0.644529924883348 0.434383431597882 0.625 27.2 27 2 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.570701128146886 0.644529924883348 0.434383431597882 0.625 27.2 27 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.0951382047535451 0.143119318991081 0.433487795656443 0.623711340206186 27.2 27 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.368308441114507 0.43494017568958 0.432744248837135 0.622641509433962 27.2 27 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.224624288181212 0.287446368778655 0.432744248837135 0.622641509433962 27.2 27 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.224624288181212 0.287446368778655 0.432744248837135 0.622641509433962 27.2 27 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.544686101834275 0.618092761491366 0.427700609573299 0.615384615384615 27.2 27 2 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.544686101834275 0.618092761491366 0.427700609573299 0.615384615384615 27.2 27 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.435197438983706 0.509700375040176 0.425518463606088 0.612244897959184 27.2 27 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.373265215748199 0.440428194037884 0.421972476409371 0.607142857142857 27.2 27 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.385873716369851 0.454928167683759 0.420923663294849 0.605633802816901 27.2 27 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.400674251785402 0.470040775177763 0.418587670448868 0.602272727272727 27.2 27 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.578499482263743 0.649784320296361 0.417008094333966 0.6 27.2 27 2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.607751758730653 0.668339066981236 0.417008094333966 0.6 27.2 27 2 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.607751758730653 0.668339066981236 0.417008094333966 0.6 27.2 27 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.455317829976283 0.523402030641609 0.415993476099577 0.598540145985402 27.2 27 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.455317829976283 0.523402030641609 0.415993476099577 0.598540145985402 27.2 27 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.483648016774536 0.552352430072363 0.413941858346216 0.595588235294118 27.2 27 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.581075120334647 0.649784320296361 0.4088314650333 0.588235294117647 27.2 27 2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.638336164125705 0.691287946385752 0.405424536158023 0.583333333333333 27.2 27 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.63354139577579 0.686617978818697 0.401345818490437 0.577464788732394 27.2 27 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.893789181900849 0.931084923751763 0.401073638696815 0.577073170731707 27.2 27 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.688195495753637 0.740213295886187 0.400353393177771 0.576036866359447 27.2 27 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.674247920642907 0.725760053763129 0.39446711626186 0.567567567567568 27.2 27 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.725231563548519 0.775943244307927 0.393138944153234 0.565656565656566 27.2 27 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.707186122539903 0.759491209339081 0.386118605864784 0.555555555555556 27.2 27 2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.712140102533829 0.763083859868703 0.386118605864784 0.555555555555556 27.2 27 2 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.712140102533829 0.763083859868703 0.386118605864784 0.555555555555556 27.2 27 2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.712140102533829 0.763083859868703 0.386118605864784 0.555555555555556 27.2 27 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.725172782084583 0.775943244307927 0.382257419806136 0.55 27.2 27 2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.730928403842272 0.78145087803723 0.379098267576333 0.545454545454545 27.2 27 2 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.762570233526273 0.814667749480395 0.370673861630192 0.533333333333333 27.2 27 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.788572690430679 0.841814657526524 0.365796573977163 0.526315789473684 27.2 27 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.878435713747233 0.919127956369348 0.36459724094773 0.524590163934426 27.2 27 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.845833991906155 0.886972564836005 0.358716640287283 0.516129032258065 27.2 27 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.853277363220992 0.894119063227888 0.358037252710981 0.515151515151515 27.2 27 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.992038721867011 1 0.351243376947964 0.505376344086022 27.2 27 2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_208000.1 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA 0.816528446337003 0.864523794001157 0.347506745278305 0.5 27.2 27 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.876543314960738 0.917822764671914 0.347506745278305 0.5 27.2 27 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.915875274206496 0.950613067247151 0.336296850269328 0.483870967741935 27.2 27 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.915875274206496 0.950613067247151 0.336296850269328 0.483870967741935 27.2 27 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.909293390408955 0.945160332032098 0.334636125082812 0.481481481481481 27.2 27 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.955228570602265 0.987138893222239 0.333027297558376 0.479166666666667 27.2 27 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.899232172654394 0.93606977446028 0.330958805026957 0.476190476190476 27.2 27 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.960604611534893 0.990536494358081 0.317720452825879 0.457142857142857 27.2 27 2 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.887861815082612 0.92752493363041 0.315915222980277 0.454545454545455 27.2 27 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.996994020658856 1 0.307917369233941 0.443037974683544 27.2 27 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.956917029578517 0.98744955263976 0.305805935844909 0.44 27.2 27 2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.956660205956633 0.98744955263976 0.302179778502874 0.434782608695652 27.2 27 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.973000583758324 0.998975346816808 0.28432370068225 0.409090909090909 27.2 27 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.973000583758324 0.998975346816808 0.28432370068225 0.409090909090909 27.2 27 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.9966671015113 1 0.280962900437779 0.404255319148936 27.2 27 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.988759119186193 1 0.278005396222644 0.4 27.2 27 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.98910034791388 1 0.27304101414724 0.392857142857143 27.2 27 2 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.983505112345125 1 0.271961800652587 0.391304347826087 27.2 27 2 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%REACT_207160.1 GLUCOCORTICOID BIOSYNTHESIS 0.962082082039456 0.991341638480916 0.267312880983312 0.384615384615385 27.2 27 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999996666569061 1 0.263847714007602 0.37962962962963 27.2 27 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.249761355128656 0.35936188077246 27.2 27 2 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.978817818834264 1 0.248219103770218 0.357142857142857 27.2 27 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.997618500270055 1 0.246617690197507 0.354838709677419 27.2 27 2 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.991641054218867 1 0.243254721694814 0.35 27.2 27 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999840889726335 1 0.236600337210761 0.340425531914894 27.2 27 2 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_220332.1 ANDROGEN BIOSYNTHESIS 0.988422680764623 1 0.23167116351887 0.333333333333333 27.2 27 2 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.988422680764623 1 0.23167116351887 0.333333333333333 27.2 27 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999919151045 1 0.223948791401574 0.322222222222222 27.2 27 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.222454589201664 0.320072332730561 27.2 27 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999972373086817 1 0.217191715798941 0.3125 27.2 27 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.999955140140673 1 0.20118811568744 0.289473684210526 27.2 27 2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.999959253392806 1 0.179358320143641 0.258064516129032 27.2 27 2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.999919010338945 1 0.166803237733586 0.24 27.2 27 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0168148425134664 0.0241935483870968 27.2 27 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 5.91509658452516e-05 0.000369174668411373 3.65030001935609 0.727272727272727 28.1 28 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 5.91509658452516e-05 0.000369174668411373 3.65030001935609 0.727272727272727 28.1 28 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00197188588606495 0.00810980813835381 3.58511609043901 0.714285714285714 28.1 28 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 3.59780479058654e-05 0.000240469754767353 3.47480482611781 0.692307692307692 28.1 28 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 5.06635036224491e-06 4.26592696181924e-05 3.45067423704755 0.6875 28.1 28 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 5.06635036224491e-06 4.26592696181924e-05 3.45067423704755 0.6875 28.1 28 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 5.06635036224491e-06 4.26592696181924e-05 3.45067423704755 0.6875 28.1 28 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.000151450706643991 0.000838577258966533 3.34610835107641 0.666666666666667 28.1 28 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 2.54376144893155e-07 3.12049357054275e-06 3.27336686518345 0.652173913043478 28.1 28 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 1.21861650949939e-05 9.03172548446684e-05 3.24769339957417 0.647058823529412 28.1 28 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 1.21861650949939e-05 9.03172548446684e-05 3.24769339957417 0.647058823529412 28.1 28 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 8.58051931030945e-05 0.000512286514458781 3.22660448139511 0.642857142857143 28.1 28 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 8.58051931030945e-05 0.000512286514458781 3.22660448139511 0.642857142857143 28.1 28 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.000615228619017688 0.00284243611968237 3.19401251693658 0.636363636363636 28.1 28 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 4.79775977774694e-05 0.000310327825624268 3.13697657913414 0.625 28.1 28 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00453763924228951 0.0157874343319755 3.13697657913414 0.625 28.1 28 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00453763924228951 0.0157874343319755 3.13697657913414 0.625 28.1 28 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00453763924228951 0.0157874343319755 3.13697657913414 0.625 28.1 28 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 2.66086577308059e-05 0.000185608431132043 3.06726598848671 0.611111111111111 28.1 28 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.000182775880543305 0.000988935657844575 3.01149751596877 0.6 28.1 28 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000182775880543305 0.000988935657844575 3.01149751596877 0.6 28.1 28 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 8.67517729923037e-09 1.52404657985245e-07 3.01149751596877 0.6 28.1 28 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 8.67517729923037e-09 1.52404657985245e-07 3.01149751596877 0.6 28.1 28 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 1.46799346078793e-05 0.00010712588177955 3.01149751596877 0.6 28.1 28 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 1.46799346078793e-05 0.00010712588177955 3.01149751596877 0.6 28.1 28 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00239298903232794 0.00906374682733212 3.01149751596877 0.6 28.1 28 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00239298903232794 0.00906374682733212 3.01149751596877 0.6 28.1 28 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00239298903232794 0.00906374682733212 3.01149751596877 0.6 28.1 28 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.00239298903232794 0.00906374682733212 3.01149751596877 0.6 28.1 28 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 8.0706822077845e-06 6.56261758952991e-05 2.96586876572682 0.590909090909091 28.1 28 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 8.0706822077845e-06 6.56261758952991e-05 2.96586876572682 0.590909090909091 28.1 28 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 9.91082158952911e-05 0.000570975672951414 2.95244854506742 0.588235294117647 28.1 28 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 9.91082158952911e-05 0.000570975672951414 2.95244854506742 0.588235294117647 28.1 28 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00126451769634087 0.0053079902120739 2.92784480719186 0.583333333333333 28.1 28 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00126451769634087 0.0053079902120739 2.92784480719186 0.583333333333333 28.1 28 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 5.37646676335376e-09 1.00667265845426e-07 2.88601845280341 0.575 28.1 28 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 2.90572133888047e-05 0.000200935113649001 2.86809287235121 0.571428571428571 28.1 28 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.000670075983987519 0.00302704166734679 2.86809287235121 0.571428571428571 28.1 28 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.000670075983987519 0.00302704166734679 2.86809287235121 0.571428571428571 28.1 28 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.000670075983987519 0.00302704166734679 2.86809287235121 0.571428571428571 28.1 28 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.28335473847998e-17 2.32086699489787e-15 2.85975539307112 0.569767441860465 28.1 28 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000356087958385095 0.00177794092905962 2.82327892122072 0.5625 28.1 28 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000356087958385095 0.00177794092905962 2.82327892122072 0.5625 28.1 28 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000356087958385095 0.00177794092905962 2.82327892122072 0.5625 28.1 28 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000356087958385095 0.00177794092905962 2.82327892122072 0.5625 28.1 28 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000356087958385095 0.00177794092905962 2.82327892122072 0.5625 28.1 28 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 8.29803459302027e-17 7.3800645161674e-15 2.7947609523195 0.556818181818182 28.1 28 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000189732663600898 0.00101882860492105 2.78842362589701 0.555555555555556 28.1 28 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00881717301282919 0.0268668890733532 2.78842362589701 0.555555555555556 28.1 28 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00881717301282919 0.0268668890733532 2.78842362589701 0.555555555555556 28.1 28 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00881717301282919 0.0268668890733532 2.78842362589701 0.555555555555556 28.1 28 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 6.80481938932145e-13 3.22775266366814e-11 2.77177632066778 0.552238805970149 28.1 28 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.80816076337877e-16 1.73739685490782e-14 2.7691931181322 0.551724137931034 28.1 28 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000101337225236945 0.00058146319158134 2.76053938963804 0.55 28.1 28 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 1.35554043443193e-06 1.38772232963787e-05 2.75244396620802 0.548387096774194 28.1 28 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.17016718591804e-19 3.08814790556138e-17 2.74194989879873 0.546296296296296 28.1 28 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 5.42410508060287e-05 0.000341526616358314 2.73772501451707 0.545454545454545 28.1 28 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00452630152830025 0.0157874343319755 2.73772501451707 0.545454545454545 28.1 28 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00452630152830025 0.0157874343319755 2.73772501451707 0.545454545454545 28.1 28 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00452630152830025 0.0157874343319755 2.73772501451707 0.545454545454545 28.1 28 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 2.9088287710256e-05 0.000200935113649001 2.71871303524959 0.541666666666667 28.1 28 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.56260481125707e-05 0.000113448298286674 2.70262597586941 0.538461538461538 28.1 28 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00234754688800938 0.00906374682733212 2.70262597586941 0.538461538461538 28.1 28 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.56191147677343e-16 1.1697894902361e-14 2.69449777744574 0.536842105263158 28.1 28 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.56191147677343e-16 1.1697894902361e-14 2.69449777744574 0.536842105263158 28.1 28 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.56191147677343e-16 1.1697894902361e-14 2.69449777744574 0.536842105263158 28.1 28 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 8.40702098618905e-06 6.75886489454634e-05 2.68883706782926 0.535714285714286 28.1 28 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.89186703266615e-08 3.02486155897071e-07 2.67688668086113 0.533333333333333 28.1 28 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 4.52926981852384e-06 3.97848824182681e-05 2.67688668086113 0.533333333333333 28.1 28 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 4.52926981852384e-06 3.97848824182681e-05 2.67688668086113 0.533333333333333 28.1 28 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00122699038792377 0.00519645036314142 2.67688668086113 0.533333333333333 28.1 28 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00122699038792377 0.00519645036314142 2.67688668086113 0.533333333333333 28.1 28 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00122699038792377 0.00519645036314142 2.67688668086113 0.533333333333333 28.1 28 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.28336962562653e-18 1.66021361569687e-16 2.66784314477714 0.531531531531532 28.1 28 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000645190168686125 0.00295210807086931 2.65720369056068 0.529411764705882 28.1 28 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000180845238269898 0.000988935657844575 2.62908513298861 0.523809523809524 28.1 28 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 6.1393948862683e-08 8.32034183158075e-07 2.62365313891219 0.522727272727273 28.1 28 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 5.13735779912907e-05 0.000325383160250881 2.6099645138396 0.52 28.1 28 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 5.13735779912907e-05 0.000325383160250881 2.6099645138396 0.52 28.1 28 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 5.13735779912907e-05 0.000325383160250881 2.6099645138396 0.52 28.1 28 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 5.13735779912907e-05 0.000325383160250881 2.6099645138396 0.52 28.1 28 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 4.25769396130608e-06 3.81050220562173e-05 2.58562918037723 0.515151515151515 28.1 28 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 2.29368495969643e-06 2.19054610580404e-05 2.58128358511609 0.514285714285714 28.1 28 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.23719707944732e-06 1.29450841474524e-05 2.57740778393724 0.513513513513513 28.1 28 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.61131834345127e-07 4.24702975432327e-06 2.57079056241237 0.51219512195122 28.1 28 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.61131834345127e-07 4.24702975432327e-06 2.57079056241237 0.51219512195122 28.1 28 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.05799921877615e-07 1.3686662621077e-06 2.56534973582525 0.511111111111111 28.1 28 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.34460521018279e-09 2.94365109860017e-08 2.50958126330731 0.5 28.1 28 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 2.83995736519628e-08 4.1063475120654e-07 2.50958126330731 0.5 28.1 28 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 5.23546384680481e-08 7.23307286796432e-07 2.50958126330731 0.5 28.1 28 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 8.71211078700105e-05 0.000512286514458781 2.50958126330731 0.5 28.1 28 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 8.71211078700105e-05 0.000512286514458781 2.50958126330731 0.5 28.1 28 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 8.71211078700105e-05 0.000512286514458781 2.50958126330731 0.5 28.1 28 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 8.71211078700105e-05 0.000512286514458781 2.50958126330731 0.5 28.1 28 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000307449425733766 0.0016025660542826 2.50958126330731 0.5 28.1 28 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.47247878121383e-09 4.69111640755638e-08 2.50958126330731 0.5 28.1 28 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.47247878121383e-09 4.69111640755638e-08 2.50958126330731 0.5 28.1 28 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.47247878121383e-09 4.69111640755638e-08 2.50958126330731 0.5 28.1 28 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.47247878121383e-09 4.69111640755638e-08 2.50958126330731 0.5 28.1 28 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.47247878121383e-09 4.69111640755638e-08 2.50958126330731 0.5 28.1 28 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.47247878121383e-09 4.69111640755638e-08 2.50958126330731 0.5 28.1 28 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.47247878121383e-09 4.69111640755638e-08 2.50958126330731 0.5 28.1 28 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 9.65788586903669e-08 1.27251588811474e-06 2.50958126330731 0.5 28.1 28 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.12724441005422e-06 1.18819910778308e-05 2.50958126330731 0.5 28.1 28 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 2.08855171649038e-06 2.02177489290192e-05 2.50958126330731 0.5 28.1 28 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 7.19607755059404e-06 5.91908575404354e-05 2.50958126330731 0.5 28.1 28 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 4.65642752517014e-05 0.000302561478005348 2.50958126330731 0.5 28.1 28 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000580476875764718 0.00269061431339803 2.50958126330731 0.5 28.1 28 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000580476875764718 0.00269061431339803 2.50958126330731 0.5 28.1 28 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00110064767377135 0.00477506597492876 2.50958126330731 0.5 28.1 28 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00209789281746244 0.00852943279785442 2.50958126330731 0.5 28.1 28 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00402501779203124 0.0143190007951511 2.50958126330731 0.5 28.1 28 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00778808536025964 0.0247929428806476 2.50958126330731 0.5 28.1 28 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00778808536025964 0.0247929428806476 2.50958126330731 0.5 28.1 28 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00778808536025964 0.0247929428806476 2.50958126330731 0.5 28.1 28 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00778808536025964 0.0247929428806476 2.50958126330731 0.5 28.1 28 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00778808536025964 0.0247929428806476 2.50958126330731 0.5 28.1 28 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00778808536025964 0.0247929428806476 2.50958126330731 0.5 28.1 28 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00778808536025964 0.0247929428806476 2.50958126330731 0.5 28.1 28 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00778808536025964 0.0247929428806476 2.50958126330731 0.5 28.1 28 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0152413569933304 0.0417021749874009 2.50958126330731 0.5 28.1 28 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0152413569933304 0.0417021749874009 2.50958126330731 0.5 28.1 28 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0152413569933304 0.0417021749874009 2.50958126330731 0.5 28.1 28 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0152413569933304 0.0417021749874009 2.50958126330731 0.5 28.1 28 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0152413569933304 0.0417021749874009 2.50958126330731 0.5 28.1 28 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0152413569933304 0.0417021749874009 2.50958126330731 0.5 28.1 28 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0152413569933304 0.0417021749874009 2.50958126330731 0.5 28.1 28 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.15276233529367e-30 7.65845200780725e-28 2.49832753566916 0.497757847533632 28.1 28 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.06576278041912e-10 3.61090580127715e-09 2.47520343778255 0.493150684931507 28.1 28 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.59065838702533e-10 8.37624079465089e-09 2.47321052036083 0.492753623188406 28.1 28 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 7.7325709606096e-18 9.16954039745622e-16 2.47097232079489 0.492307692307692 28.1 28 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.82913128535993e-11 1.15024394830491e-09 2.44684173172463 0.4875 28.1 28 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.30176795001107e-16 1.48882536039352e-14 2.42862702900707 0.483870967741935 28.1 28 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.30176795001107e-16 1.48882536039352e-14 2.42862702900707 0.483870967741935 28.1 28 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.30176795001107e-16 1.48882536039352e-14 2.42862702900707 0.483870967741935 28.1 28 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 7.61899200586905e-08 1.02281373814638e-06 2.41663380911074 0.481481481481481 28.1 28 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.000266843975459059 0.00140117703718908 2.40919801277502 0.48 28.1 28 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 9.46090180809717e-10 2.1035723863941e-08 2.40354261837883 0.47887323943662 28.1 28 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.73448635542484e-09 3.62966777024934e-08 2.40046903446786 0.478260869565217 28.1 28 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 8.77779292567283e-07 9.46272676760033e-06 2.40046903446786 0.478260869565217 28.1 28 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 8.77779292567283e-07 9.46272676760033e-06 2.40046903446786 0.478260869565217 28.1 28 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000501045932813361 0.00239257839729333 2.40046903446786 0.478260869565217 28.1 28 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 2.99126528267107e-06 2.76400681639022e-05 2.39007739362601 0.476190476190476 28.1 28 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000943778364396371 0.00418379007020572 2.39007739362601 0.476190476190476 28.1 28 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000943778364396371 0.00418379007020572 2.39007739362601 0.476190476190476 28.1 28 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00178441423471482 0.00740297800582853 2.37749803892271 0.473684210526316 28.1 28 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.89409691450614e-05 0.000134764995467112 2.37016008201246 0.472222222222222 28.1 28 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 3.51163567458672e-05 0.000236827372745825 2.36195883605394 0.470588235294118 28.1 28 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 7.56052833075263e-07 8.31754435126242e-06 2.35593343085992 0.469387755102041 28.1 28 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 6.51879907944195e-05 0.000401569311257398 2.3527324343506 0.46875 28.1 28 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.39132788658777e-06 1.40415573235064e-05 2.34939522522386 0.468085106382979 28.1 28 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.39132788658777e-06 1.40415573235064e-05 2.34939522522386 0.468085106382979 28.1 28 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00012118333055965 0.000684301108676117 2.34227584575349 0.466666666666667 28.1 28 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00647329177062527 0.0213569977985854 2.34227584575349 0.466666666666667 28.1 28 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00647329177062527 0.0213569977985854 2.34227584575349 0.466666666666667 28.1 28 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00647329177062527 0.0213569977985854 2.34227584575349 0.466666666666667 28.1 28 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00647329177062527 0.0213569977985854 2.34227584575349 0.466666666666667 28.1 28 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 8.69976865587732e-06 6.80207186665573e-05 2.32595336599214 0.463414634146341 28.1 28 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 8.69976865587732e-06 6.80207186665573e-05 2.32595336599214 0.463414634146341 28.1 28 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 8.69976865587732e-06 6.80207186665573e-05 2.32595336599214 0.463414634146341 28.1 28 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 8.69976865587732e-06 6.80207186665573e-05 2.32595336599214 0.463414634146341 28.1 28 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 6.43149840057667e-07 7.15001736251609e-06 2.31653655074521 0.461538461538462 28.1 28 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0124514040507599 0.0360129023663238 2.31653655074521 0.461538461538462 28.1 28 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0124514040507599 0.0360129023663238 2.31653655074521 0.461538461538462 28.1 28 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0124514040507599 0.0360129023663238 2.31653655074521 0.461538461538462 28.1 28 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0124514040507599 0.0360129023663238 2.31653655074521 0.461538461538462 28.1 28 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0124514040507599 0.0360129023663238 2.31653655074521 0.461538461538462 28.1 28 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.96242098619126e-05 0.000202542673448906 2.30610170141753 0.459459459459459 28.1 28 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.96242098619126e-05 0.000202542673448906 2.30610170141753 0.459459459459459 28.1 28 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 6.72256773506859e-09 1.24236543987047e-07 2.30044949136503 0.458333333333333 28.1 28 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00078673095046929 0.00350946126181129 2.30044949136503 0.458333333333333 28.1 28 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0241705698808556 0.0613096629954678 2.28143751209755 0.454545454545455 28.1 28 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0241705698808556 0.0613096629954678 2.28143751209755 0.454545454545455 28.1 28 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0241705698808556 0.0613096629954678 2.28143751209755 0.454545454545455 28.1 28 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0241705698808556 0.0613096629954678 2.28143751209755 0.454545454545455 28.1 28 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0241705698808556 0.0613096629954678 2.28143751209755 0.454545454545455 28.1 28 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.81175544222075e-06 1.78417701612982e-05 2.26354388455169 0.450980392156863 28.1 28 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.46545966742354e-05 0.000172825079149936 2.25862313697658 0.45 28.1 28 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00276945389203762 0.0101049561240245 2.25862313697658 0.45 28.1 28 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00276945389203762 0.0101049561240245 2.25862313697658 0.45 28.1 28 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00276945389203762 0.0101049561240245 2.25862313697658 0.45 28.1 28 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00276945389203762 0.0101049561240245 2.25862313697658 0.45 28.1 28 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 3.31452684071546e-06 3.02344339380648e-05 2.25350154256167 0.448979591836735 28.1 28 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000346999696564816 0.00176350202932762 2.24996940848242 0.448275862068966 28.1 28 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 6.06409947300906e-06 5.04632371350403e-05 2.24260453316823 0.446808510638298 28.1 28 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 8.33597701081672e-05 0.000502631156203059 2.23073890071761 0.444444444444444 28.1 28 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00064360835228118 0.00295210807086931 2.23073890071761 0.444444444444444 28.1 28 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00064360835228118 0.00295210807086931 2.23073890071761 0.444444444444444 28.1 28 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00522001317045741 0.0176438924977694 2.23073890071761 0.444444444444444 28.1 28 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00522001317045741 0.0176438924977694 2.23073890071761 0.444444444444444 28.1 28 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00522001317045741 0.0176438924977694 2.23073890071761 0.444444444444444 28.1 28 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00522001317045741 0.0176438924977694 2.23073890071761 0.444444444444444 28.1 28 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.98745497964906e-21 6.30460937337845e-19 2.22277197607219 0.442857142857143 28.1 28 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.54178354660561e-11 1.36215080724859e-09 2.22001419446416 0.442307692307692 28.1 28 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 4.56712295729766e-10 1.04822838197332e-08 2.21274907087311 0.440860215053763 28.1 28 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.34936636465378e-08 3.55654078393865e-07 2.20843151171043 0.44 28.1 28 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.34936636465378e-08 3.55654078393865e-07 2.20843151171043 0.44 28.1 28 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.34936636465378e-08 3.55654078393865e-07 2.20843151171043 0.44 28.1 28 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.34936636465378e-08 3.55654078393865e-07 2.20843151171043 0.44 28.1 28 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.34936636465378e-08 3.55654078393865e-07 2.20843151171043 0.44 28.1 28 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0098763798453075 0.0299023159997289 2.1958836053939 0.4375 28.1 28 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0098763798453075 0.0299023159997289 2.1958836053939 0.4375 28.1 28 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 2.24602284854045e-06 2.15952061721153e-05 2.19018001161365 0.436363636363636 28.1 28 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.3931286598505e-07 1.78596584051104e-06 2.18224457678897 0.434782608695652 28.1 28 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00222251905466792 0.00890885806983789 2.18224457678897 0.434782608695652 28.1 28 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.41176484835624e-10 4.4643141760243e-09 2.17175301632363 0.432692307692308 28.1 28 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.58244377515135e-08 2.68073510957187e-07 2.16877393125323 0.432098765432099 28.1 28 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.58244377515135e-08 2.68073510957187e-07 2.16877393125323 0.432098765432099 28.1 28 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.83056812617676e-06 1.78417701612982e-05 2.16343212354078 0.431034482758621 28.1 28 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.83056812617676e-06 1.78417701612982e-05 2.16343212354078 0.431034482758621 28.1 28 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 2.85198388746319e-08 4.1063475120654e-07 2.16014589753034 0.430379746835443 28.1 28 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 2.85198388746319e-08 4.1063475120654e-07 2.16014589753034 0.430379746835443 28.1 28 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.85198388746319e-08 4.1063475120654e-07 2.16014589753034 0.430379746835443 28.1 28 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.15484078234788e-10 3.82171728670009e-09 2.15777080583432 0.429906542056075 28.1 28 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.33060883055518e-11 5.56898931141184e-10 2.15106965426341 0.428571428571429 28.1 28 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000227342902063736 0.00121164400612995 2.15106965426341 0.428571428571429 28.1 28 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00413871053776855 0.0146502116797131 2.15106965426341 0.428571428571429 28.1 28 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00413871053776855 0.0146502116797131 2.15106965426341 0.428571428571429 28.1 28 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000957085746711272 0.00422960564462777 2.15106965426341 0.428571428571429 28.1 28 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0187711937448063 0.0492830418798144 2.15106965426341 0.428571428571429 28.1 28 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0187711937448063 0.0492830418798144 2.15106965426341 0.428571428571429 28.1 28 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0187711937448063 0.0492830418798144 2.15106965426341 0.428571428571429 28.1 28 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0187711937448063 0.0492830418798144 2.15106965426341 0.428571428571429 28.1 28 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0187711937448063 0.0492830418798144 2.15106965426341 0.428571428571429 28.1 28 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0187711937448063 0.0492830418798144 2.15106965426341 0.428571428571429 28.1 28 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0187711937448063 0.0492830418798144 2.15106965426341 0.428571428571429 28.1 28 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0187711937448063 0.0492830418798144 2.15106965426341 0.428571428571429 28.1 28 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000415684936084038 0.00205388772238745 2.12934167795772 0.424242424242424 28.1 28 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.88129007200075e-08 3.02486155897071e-07 2.12576295244855 0.423529411764706 28.1 28 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.88129007200075e-08 3.02486155897071e-07 2.12576295244855 0.423529411764706 28.1 28 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.88129007200075e-08 3.02486155897071e-07 2.12576295244855 0.423529411764706 28.1 28 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.88129007200075e-08 3.02486155897071e-07 2.12576295244855 0.423529411764706 28.1 28 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00176304928610143 0.00733572846234599 2.12349183818311 0.423076923076923 28.1 28 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.41231950023888e-05 0.000289342426213822 2.11920195568173 0.422222222222222 28.1 28 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.37268647831849e-08 4.79933285864721e-07 2.11651431845195 0.421686746987952 28.1 28 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000181737668004595 0.000988935657844575 2.11333159015352 0.421052631578947 28.1 28 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00771863057827022 0.0247929428806476 2.11333159015352 0.421052631578947 28.1 28 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00771863057827022 0.0247929428806476 2.11333159015352 0.421052631578947 28.1 28 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.73207632814039e-09 3.62966777024934e-08 2.10804826117814 0.42 28.1 28 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 7.98724615225936e-05 0.000485720139942952 2.10104477858286 0.418604651162791 28.1 28 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 9.62622072685758e-07 1.02224717121779e-05 2.09756045888372 0.417910447761194 28.1 28 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000330187996317715 0.00168407712817243 2.09131771942276 0.416666666666667 28.1 28 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000330187996317715 0.00168407712817243 2.09131771942276 0.416666666666667 28.1 28 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00324808198623836 0.0117013181428283 2.09131771942276 0.416666666666667 28.1 28 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.035872344538424 0.0846539739273256 2.09131771942276 0.416666666666667 28.1 28 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.035872344538424 0.0846539739273256 2.09131771942276 0.416666666666667 28.1 28 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.035872344538424 0.0846539739273256 2.09131771942276 0.416666666666667 28.1 28 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.035872344538424 0.0846539739273256 2.09131771942276 0.416666666666667 28.1 28 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.035872344538424 0.0846539739273256 2.09131771942276 0.416666666666667 28.1 28 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 5.81883115506587e-11 2.07004918341468e-09 2.08111616957192 0.414634146341463 28.1 28 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00138773472328525 0.00580807797422032 2.07689483859915 0.413793103448276 28.1 28 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 6.35118249946894e-05 0.000392944899858448 2.07313234794952 0.41304347826087 28.1 28 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.08778568750464e-06 2.8347864731091e-05 2.07140040780921 0.412698412698413 28.1 28 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0144174168944494 0.0406257113679236 2.0667139815472 0.411764705882353 28.1 28 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0144174168944494 0.0406257113679236 2.0667139815472 0.411764705882353 28.1 28 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0144174168944494 0.0406257113679236 2.0667139815472 0.411764705882353 28.1 28 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0144174168944494 0.0406257113679236 2.0667139815472 0.411764705882353 28.1 28 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0144174168944494 0.0406257113679236 2.0667139815472 0.411764705882353 28.1 28 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0144174168944494 0.0406257113679236 2.0667139815472 0.411764705882353 28.1 28 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000114276352230136 0.000647869518818661 2.0532937608878 0.409090909090909 28.1 28 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000114276352230136 0.000647869518818661 2.0532937608878 0.409090909090909 28.1 28 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00598347380856702 0.0201765005440542 2.0532937608878 0.409090909090909 28.1 28 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.38107574316372e-06 3.89641923907623e-05 2.03903477643719 0.40625 28.1 28 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.11050013351622e-22 2.25748812856226e-20 2.03849945620184 0.406143344709898 28.1 28 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.43916934534704e-09 3.10293633095279e-08 2.02527610723046 0.403508771929825 28.1 28 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 8.93264137982079e-39 6.35557434174249e-36 2.02293242517547 0.403041825095057 28.1 28 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.73948247862808e-06 2.54789775626651e-05 2.00766501064585 0.4 28.1 28 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0046166609279362 0.0159842055972098 2.00766501064585 0.4 28.1 28 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0110180817024253 0.0328006909258393 2.00766501064585 0.4 28.1 28 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0110180817024253 0.0328006909258393 2.00766501064585 0.4 28.1 28 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0269697950609271 0.0677068207278293 2.00766501064585 0.4 28.1 28 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0269697950609271 0.0677068207278293 2.00766501064585 0.4 28.1 28 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000126007285574756 0.000708728724793981 1.98675183345162 0.395833333333333 28.1 28 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 7.5985998992559e-07 8.31754435126242e-06 1.9828790228601 0.395061728395062 28.1 28 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000658931298923808 0.00300531807169416 1.98124836576893 0.394736842105263 28.1 28 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 5.97738599673197e-07 6.75065101059491e-06 1.97181384974146 0.392857142857143 28.1 28 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 5.97738599673197e-07 6.75065101059491e-06 1.97181384974146 0.392857142857143 28.1 28 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.33578980918239e-06 1.37741224526561e-05 1.96954478892472 0.392405063291139 28.1 28 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.83920981799948e-05 0.000570975672951414 1.96829903004495 0.392156862745098 28.1 28 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.83920981799948e-05 0.000570975672951414 1.96829903004495 0.392156862745098 28.1 28 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 9.83920981799948e-05 0.000570975672951414 1.96829903004495 0.392156862745098 28.1 28 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00840123043607361 0.0266051015012889 1.96402011911007 0.391304347826087 28.1 28 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.88733988707805e-13 9.59173092611449e-12 1.95935221627202 0.390374331550802 28.1 28 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000511389796919794 0.00241763349175039 1.9586975713618 0.390243902439024 28.1 28 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000511389796919794 0.00241763349175039 1.9586975713618 0.390243902439024 28.1 28 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000511389796919794 0.00241763349175039 1.9586975713618 0.390243902439024 28.1 28 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.29717280611476e-28 3.69175380620262e-26 1.95582389534748 0.389671361502347 28.1 28 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00117634758085556 0.00505722842162376 1.95189653812791 0.388888888888889 28.1 28 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0202703101733533 0.0522548032186263 1.95189653812791 0.388888888888889 28.1 28 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0202703101733533 0.0522548032186263 1.95189653812791 0.388888888888889 28.1 28 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 3.54574281972596e-12 1.62761033305485e-10 1.9486160397445 0.388235294117647 28.1 28 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.00342396828414e-17 1.09836331297564e-15 1.9422812842455 0.386973180076628 28.1 28 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 3.58996589898173e-08 5.05794205371386e-07 1.93398923043866 0.385321100917431 28.1 28 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00640016820408294 0.0213288977855036 1.93044712562101 0.384615384615385 28.1 28 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0505104323432142 0.112131583813407 1.93044712562101 0.384615384615385 28.1 28 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0505104323432142 0.112131583813407 1.93044712562101 0.384615384615385 28.1 28 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0505104323432142 0.112131583813407 1.93044712562101 0.384615384615385 28.1 28 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0505104323432142 0.112131583813407 1.93044712562101 0.384615384615385 28.1 28 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0505104323432142 0.112131583813407 1.93044712562101 0.384615384615385 28.1 28 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0505104323432142 0.112131583813407 1.93044712562101 0.384615384615385 28.1 28 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0505104323432142 0.112131583813407 1.93044712562101 0.384615384615385 28.1 28 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 8.39574872597873e-12 3.73348451158367e-10 1.93044712562101 0.384615384615385 28.1 28 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.06381170050518e-05 0.000145386339099944 1.93044712562101 0.384615384615385 28.1 28 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 7.1707197876446e-06 5.91908575404354e-05 1.92515822938643 0.383561643835616 28.1 28 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00209387403074173 0.00852943279785442 1.91909155429383 0.382352941176471 28.1 28 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0152515408806756 0.0417021749874009 1.91206191490081 0.380952380952381 28.1 28 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 6.45892413932093e-14 3.4040922408347e-12 1.91206191490081 0.380952380952381 28.1 28 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000237176571202684 0.00125000837341266 1.90728176011356 0.38 28.1 28 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00487486004955643 0.0167154839771537 1.90382026871589 0.379310344827586 28.1 28 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00487486004955643 0.0167154839771537 1.90382026871589 0.379310344827586 28.1 28 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.65158121925655e-10 5.10913059783059e-09 1.89827300686066 0.378205128205128 28.1 28 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.38539350778076e-06 3.06841717297581e-05 1.89748827225675 0.378048780487805 28.1 28 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.21086956669009e-09 1.47899587258228e-07 1.89700630927167 0.377952755905512 28.1 28 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.68487189165121e-05 0.000121704198061913 1.88218594748048 0.375 28.1 28 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0114931195059748 0.0336648733472917 1.88218594748048 0.375 28.1 28 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0114931195059748 0.0336648733472917 1.88218594748048 0.375 28.1 28 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00123141283037836 0.00519970462204275 1.88218594748048 0.375 28.1 28 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0372258441902988 0.0865561703967242 1.88218594748048 0.375 28.1 28 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0372258441902988 0.0865561703967242 1.88218594748048 0.375 28.1 28 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0372258441902988 0.0865561703967242 1.88218594748048 0.375 28.1 28 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0372258441902988 0.0865561703967242 1.88218594748048 0.375 28.1 28 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0372258441902988 0.0865561703967242 1.88218594748048 0.375 28.1 28 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.35094566720995e-10 4.36908110099944e-09 1.87833689646314 0.374233128834356 28.1 28 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.95869808125232e-07 2.44493628914215e-06 1.87632243985593 0.373831775700935 28.1 28 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.76687325621736e-05 0.000250479469326977 1.87282183828904 0.373134328358209 28.1 28 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00867517013113004 0.0266051015012889 1.85894908393134 0.37037037037037 28.1 28 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00867517013113004 0.0266051015012889 1.85894908393134 0.37037037037037 28.1 28 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00867517013113004 0.0266051015012889 1.85894908393134 0.37037037037037 28.1 28 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00867517013113004 0.0266051015012889 1.85894908393134 0.37037037037037 28.1 28 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00867517013113004 0.0266051015012889 1.85894908393134 0.37037037037037 28.1 28 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00867517013113004 0.0266051015012889 1.85894908393134 0.37037037037037 28.1 28 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00867517013113004 0.0266051015012889 1.85894908393134 0.37037037037037 28.1 28 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000723941252911907 0.003249742595879 1.85490789027062 0.369565217391304 28.1 28 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.1953848047568e-15 1.20155099121882e-13 1.85322924059617 0.369230769230769 28.1 28 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.26584949458437e-10 1.18941330647517e-08 1.85081618168914 0.36875 28.1 28 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.7416596567396e-05 0.000124541793544746 1.84916514138433 0.368421052631579 28.1 28 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.027592123270485 0.0682968468200783 1.84916514138433 0.368421052631579 28.1 28 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.027592123270485 0.0682968468200783 1.84916514138433 0.368421052631579 28.1 28 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.69621251244104e-06 4.02572915976121e-05 1.84612874542147 0.367816091954023 28.1 28 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.69621251244104e-06 4.02572915976121e-05 1.84612874542147 0.367816091954023 28.1 28 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.78513949765564e-11 3.0490862207717e-09 1.84319527813531 0.367231638418079 28.1 28 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00655868449612216 0.0213569977985854 1.84035959309203 0.366666666666667 28.1 28 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00655868449612216 0.0213569977985854 1.84035959309203 0.366666666666667 28.1 28 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.63448665338816e-06 3.27333829605782e-05 1.84035959309203 0.366666666666667 28.1 28 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 3.87484265709524e-05 0.000256460516327745 1.83800317876028 0.366197183098592 28.1 28 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.69015572344655e-07 3.27187315766192e-06 1.83737199634999 0.366071428571429 28.1 28 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.98903453438302e-05 0.000202542673448906 1.83131605700804 0.364864864864865 28.1 28 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.98903453438302e-05 0.000202542673448906 1.83131605700804 0.364864864864865 28.1 28 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0205475792075947 0.0528737888108631 1.82515000967804 0.363636363636364 28.1 28 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.68307171724044e-06 1.67483290463857e-05 1.82515000967804 0.363636363636364 28.1 28 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000326670869137523 0.00168407712817243 1.82515000967804 0.363636363636364 28.1 28 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00496606830365046 0.0169872961444582 1.82515000967804 0.363636363636364 28.1 28 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.6449376610162e-07 2.0714568952443e-06 1.81018976369708 0.360655737704918 28.1 28 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0153611274561214 0.0418752574139095 1.80689850958126 0.36 28.1 28 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.1535209191388e-27 2.73576711322419e-25 1.80464270619852 0.359550561797753 28.1 28 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000147714999433028 0.000821087672629685 1.80376153300213 0.359375 28.1 28 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.000561342819738185 0.00261898633602438 1.79932241520147 0.358490566037736 28.1 28 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00217295571247572 0.00873479090071457 1.79255804521951 0.357142857142857 28.1 28 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0115212883486515 0.0336648733472917 1.79255804521951 0.357142857142857 28.1 28 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0115212883486515 0.0336648733472917 1.79255804521951 0.357142857142857 28.1 28 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0115212883486515 0.0336648733472917 1.79255804521951 0.357142857142857 28.1 28 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0115212883486515 0.0336648733472917 1.79255804521951 0.357142857142857 28.1 28 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.068143342675663 0.143869401524434 1.79255804521951 0.357142857142857 28.1 28 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.068143342675663 0.143869401524434 1.79255804521951 0.357142857142857 28.1 28 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 5.14484968773354e-05 0.000325383160250881 1.78312352919204 0.355263157894737 28.1 28 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00866525350302452 0.0266051015012889 1.78099315460519 0.354838709677419 28.1 28 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 7.55509860770371e-09 1.37832119471313e-07 1.77894368031911 0.354430379746835 28.1 28 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00653271972523703 0.0213569977985854 1.77146912704045 0.352941176470588 28.1 28 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00653271972523703 0.0213569977985854 1.77146912704045 0.352941176470588 28.1 28 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00653271972523703 0.0213569977985854 1.77146912704045 0.352941176470588 28.1 28 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00653271972523703 0.0213569977985854 1.77146912704045 0.352941176470588 28.1 28 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0496668045334894 0.111476124370908 1.77146912704045 0.352941176470588 28.1 28 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0496668045334894 0.111476124370908 1.77146912704045 0.352941176470588 28.1 28 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0496668045334894 0.111476124370908 1.77146912704045 0.352941176470588 28.1 28 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 9.78626967883395e-09 1.69827582353423e-07 1.76775535528565 0.352201257861635 28.1 28 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.43017440468728e-41 2.03513817786999e-38 1.76011355571327 0.350678733031674 28.1 28 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.94586500418976e-08 1.29843723862037e-06 1.75670688431512 0.35 28.1 28 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.036516607191748 0.0858894744361279 1.75670688431512 0.35 28.1 28 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.036516607191748 0.0858894744361279 1.75670688431512 0.35 28.1 28 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 6.07757349931329e-07 6.80975361379748e-06 1.75466657434495 0.349593495934959 28.1 28 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000326784966295298 0.00168407712817243 1.75272342199241 0.349206349206349 28.1 28 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00283124255630059 0.0102776993816728 1.75087064881905 0.348837209302326 28.1 28 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.78806155495537e-07 3.36221321415381e-06 1.74910209260813 0.348484848484849 28.1 28 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00214918284095403 0.00868831585987949 1.74579566143117 0.347826086956522 28.1 28 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00214918284095403 0.00868831585987949 1.74579566143117 0.347826086956522 28.1 28 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0270256318857393 0.0677068207278293 1.74579566143117 0.347826086956522 28.1 28 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0270256318857393 0.0677068207278293 1.74579566143117 0.347826086956522 28.1 28 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.000146569427778169 0.000817914885209155 1.74276476618563 0.347222222222222 28.1 28 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000146569427778169 0.000817914885209155 1.74276476618563 0.347222222222222 28.1 28 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0201051647072006 0.0520988286445688 1.73740241305891 0.346153846153846 28.1 28 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0201051647072006 0.0520988286445688 1.73740241305891 0.346153846153846 28.1 28 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0201051647072006 0.0520988286445688 1.73740241305891 0.346153846153846 28.1 28 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0201051647072006 0.0520988286445688 1.73740241305891 0.346153846153846 28.1 28 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0201051647072006 0.0520988286445688 1.73740241305891 0.346153846153846 28.1 28 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0201051647072006 0.0520988286445688 1.73740241305891 0.346153846153846 28.1 28 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.57981157730635e-07 4.24702975432327e-06 1.73595094905468 0.345864661654135 28.1 28 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.12791342363286e-07 2.63306156680831e-06 1.73323598041368 0.345323741007194 28.1 28 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.01501940850607 0.0417021749874009 1.73074569883263 0.344827586206897 28.1 28 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000550766773208529 0.00258660435074501 1.72790841080175 0.344262295081967 28.1 28 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000550766773208529 0.00258660435074501 1.72790841080175 0.344262295081967 28.1 28 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.47805958976136e-08 6.24733215316708e-07 1.72633615565089 0.343949044585987 28.1 28 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0112588544759753 0.0333084197906712 1.72533711852378 0.34375 28.1 28 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 5.94203338428828e-07 6.75065101059491e-06 1.72413979921876 0.343511450381679 28.1 28 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 5.94203338428828e-07 6.75065101059491e-06 1.72413979921876 0.343511450381679 28.1 28 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 3.28901829971061e-11 1.30007584458006e-09 1.72331760570459 0.343347639484979 28.1 28 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000188039821827764 0.00101356313053375 1.71889127623788 0.342465753424658 28.1 28 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 9.60327194526781e-08 1.27251588811474e-06 1.71708191699974 0.342105263157895 28.1 28 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00637910246401853 0.0213085981368506 1.71708191699974 0.342105263157895 28.1 28 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0048178122098638 0.0166401620743597 1.71386037494158 0.341463414634146 28.1 28 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00364538720138096 0.0130664634447484 1.71107813407317 0.340909090909091 28.1 28 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.94172085869954e-10 5.87886974878605e-09 1.71107813407317 0.340909090909091 28.1 28 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 1.72519369833404e-05 0.000123987405693401 1.70651525904897 0.34 28.1 28 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00209685413717685 0.00852943279785442 1.70651525904897 0.34 28.1 28 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.00121235883212243 0.00519634523527174 1.70293014295853 0.339285714285714 28.1 28 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.73946459210358e-06 2.54789775626651e-05 1.70070796356363 0.338842975206612 28.1 28 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.73946459210358e-06 2.54789775626651e-05 1.70070796356363 0.338842975206612 28.1 28 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000703883552153223 0.00316970346428493 1.70003892030495 0.338709677419355 28.1 28 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 6.31263217412236e-05 0.000392265309335202 1.69185253706111 0.337078651685393 28.1 28 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 9.92218210401032e-06 7.67351365978624e-05 1.68826375895219 0.336363636363636 28.1 28 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 9.92218210401032e-06 7.67351365978624e-05 1.68826375895219 0.336363636363636 28.1 28 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0108137496668598 0.0323276591931544 1.67305417553821 0.333333333333333 28.1 28 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0108137496668598 0.0323276591931544 1.67305417553821 0.333333333333333 28.1 28 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.0192497705110438 0.0504464520022382 1.67305417553821 0.333333333333333 28.1 28 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.025820161995236 0.0652612620234828 1.67305417553821 0.333333333333333 28.1 28 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.0347918880756216 0.0834887971865254 1.67305417553821 0.333333333333333 28.1 28 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0471491403472842 0.107808880691502 1.67305417553821 0.333333333333333 28.1 28 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0643650517135578 0.136499953186874 1.67305417553821 0.333333333333333 28.1 28 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0643650517135578 0.136499953186874 1.67305417553821 0.333333333333333 28.1 28 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0887301164830309 0.180375651079076 1.67305417553821 0.333333333333333 28.1 28 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0887301164830309 0.180375651079076 1.67305417553821 0.333333333333333 28.1 28 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0887301164830309 0.180375651079076 1.67305417553821 0.333333333333333 28.1 28 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.5878728098427e-06 2.45502867227078e-05 1.67305417553821 0.333333333333333 28.1 28 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.59944186686199e-05 0.000240469754767353 1.67305417553821 0.333333333333333 28.1 28 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000177458038647972 0.000978770499984743 1.67305417553821 0.333333333333333 28.1 28 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.00023189926537143 0.00122673849302433 1.67305417553821 0.333333333333333 28.1 28 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00813927130479442 0.0258530872025055 1.67305417553821 0.333333333333333 28.1 28 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0144052475621377 0.0406257113679236 1.67305417553821 0.333333333333333 28.1 28 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0144052475621377 0.0406257113679236 1.67305417553821 0.333333333333333 28.1 28 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 9.57757705584307e-12 4.12996731832263e-10 1.66701426876731 0.332129963898917 28.1 28 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.48137568022945e-06 1.48450534715951e-05 1.66101781456311 0.330935251798561 28.1 28 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.0468369224083e-05 0.000144907907491891 1.65770505466171 0.330275229357798 28.1 28 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 4.52257902449511e-05 0.000295212383112686 1.65632363378282 0.33 28.1 28 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000381289551757377 0.00189711549703059 1.65104030480744 0.328947368421053 28.1 28 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.01673606928362e-08 8.23251483326018e-07 1.64562705790643 0.327868852459016 28.1 28 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.000213493568612052 0.0011421103313344 1.63414593889778 0.325581395348837 28.1 28 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0102598313464847 0.0308393924546653 1.63122782114975 0.325 28.1 28 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0102598313464847 0.0308393924546653 1.63122782114975 0.325 28.1 28 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0136354667056231 0.0390407829418545 1.62783649511826 0.324324324324324 28.1 28 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0136354667056231 0.0390407829418545 1.62783649511826 0.324324324324324 28.1 28 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00106949700609489 0.00466838723826083 1.62384669978708 0.323529411764706 28.1 28 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.51906401806714e-35 1.19487603256985e-32 1.62281230840493 0.323323323323323 28.1 28 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 5.73918168169463e-07 6.69414387955038e-06 1.62204642628399 0.323170731707317 28.1 28 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.0628310248052e-05 8.17518134215024e-05 1.62035955583622 0.322834645669291 28.1 28 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.25341180582791e-06 1.30190145963001e-05 1.61908468600472 0.32258064516129 28.1 28 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.49390992600044e-07 1.89806591490949e-06 1.61819994027466 0.322404371584699 28.1 28 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.61876025939762e-06 4.00761942019684e-05 1.61330224069756 0.321428571428571 28.1 28 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.0031807043951433 0.0114876709499719 1.61330224069756 0.321428571428571 28.1 28 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0325933126699338 0.0783450742049254 1.61330224069756 0.321428571428571 28.1 28 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.0325933126699338 0.0783450742049254 1.61330224069756 0.321428571428571 28.1 28 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000452771288827713 0.0021799133919551 1.61108920607383 0.320987654320988 28.1 28 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000113590439774607 0.000647869518818661 1.60613200851668 0.32 28.1 28 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0439357754259745 0.101659525904328 1.60613200851668 0.32 28.1 28 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.06223925710451e-10 8.37624079465089e-09 1.60539389638041 0.319852941176471 28.1 28 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0010131602608155 0.0044635512419209 1.60334358489078 0.319444444444444 28.1 28 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 5.7004689625931e-06 4.77162784339411e-05 1.60186038083445 0.319148936170213 28.1 28 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000328230325870852 0.00168407712817243 1.59700625846829 0.318181818181818 28.1 28 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0595632022124726 0.128227589634415 1.59700625846829 0.318181818181818 28.1 28 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0595632022124726 0.128227589634415 1.59700625846829 0.318181818181818 28.1 28 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0595632022124726 0.128227589634415 1.59700625846829 0.318181818181818 28.1 28 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.76595494696001e-13 1.35722547914624e-11 1.59700625846829 0.318181818181818 28.1 28 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 8.2634785691075e-05 0.000500380000163403 1.59487407387754 0.317757009345794 28.1 28 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 0.000428397997954815 0.0020735045955432 1.59432221433641 0.317647058823529 28.1 28 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000428397997954815 0.0020735045955432 1.59432221433641 0.317647058823529 28.1 28 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000428397997954815 0.0020735045955432 1.59432221433641 0.317647058823529 28.1 28 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000428397997954815 0.0020735045955432 1.59432221433641 0.317647058823529 28.1 28 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000428397997954815 0.0020735045955432 1.59432221433641 0.317647058823529 28.1 28 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000428397997954815 0.0020735045955432 1.59432221433641 0.317647058823529 28.1 28 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.0022818314473668 0.00906374682733212 1.59338492908401 0.317460317460317 28.1 28 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000559406493934724 0.00261853763443787 1.59144177673146 0.317073170731707 28.1 28 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.00018239499742672 0.000988935657844575 1.58769426862299 0.316326530612245 28.1 28 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0813371725334372 0.166536397863426 1.58499869261514 0.315789473684211 28.1 28 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0813371725334372 0.166536397863426 1.58499869261514 0.315789473684211 28.1 28 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000309720088608303 0.00160850980324677 1.582127318172 0.315217391304348 28.1 28 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00518283656246267 0.0176438924977694 1.58010672134164 0.314814814814815 28.1 28 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 8.59924410684368e-06 6.80207186665573e-05 1.57945673914446 0.314685314685315 28.1 28 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00163573964483319 0.00682597511612207 1.57745107979317 0.314285714285714 28.1 28 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0226189776927379 0.0579942437058849 1.57745107979317 0.314285714285714 28.1 28 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 4.00864094923833e-11 1.50113054493846e-09 1.57041281507574 0.312883435582822 28.1 28 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.112141149343364 0.217407160103006 1.56848828956707 0.3125 28.1 28 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.112141149343364 0.217407160103006 1.56848828956707 0.3125 28.1 28 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.112141149343364 0.217407160103006 1.56848828956707 0.3125 28.1 28 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.112141149343364 0.217407160103006 1.56848828956707 0.3125 28.1 28 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.112141149343364 0.217407160103006 1.56848828956707 0.3125 28.1 28 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.112141149343364 0.217407160103006 1.56848828956707 0.3125 28.1 28 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00368492379384342 0.0131749913533648 1.56334570501111 0.311475409836066 28.1 28 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.07767126881434e-15 6.38969256467834e-14 1.56083712717894 0.310975609756098 28.1 28 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00483917401627295 0.0166734736686596 1.55767112894936 0.310344827586207 28.1 28 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00636156944102118 0.0213000313284074 1.55137750822634 0.309090909090909 28.1 28 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00636156944102118 0.0213000313284074 1.55137750822634 0.309090909090909 28.1 28 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00636156944102118 0.0213000313284074 1.55137750822634 0.309090909090909 28.1 28 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00109594634611456 0.00476920994043124 1.54912423660945 0.308641975308642 28.1 28 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.00186743175005079 0.00770247936325296 1.53920984149515 0.306666666666667 28.1 28 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 7.86504729053248e-05 0.000482006614923143 1.53813045170448 0.306451612903226 28.1 28 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 8.14308113304318e-06 6.58386616609116e-05 1.53711852377573 0.30625 28.1 28 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00102161252583271 0.00447309115156907 1.53527324343506 0.305882352941176 28.1 28 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00102161252583271 0.00447309115156907 1.53527324343506 0.305882352941176 28.1 28 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00243950459231778 0.00906374682733212 1.53363299424336 0.305555555555556 28.1 28 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0145599151653051 0.0409461645854331 1.52757120375228 0.304347826086957 28.1 28 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0737983892304186 0.152195808514327 1.52757120375228 0.304347826086957 28.1 28 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 5.15728675408091e-22 9.17352381382142e-20 1.52310053624541 0.303457106274008 28.1 28 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0370863264824022 0.0865561703967242 1.52095834139837 0.303030303030303 28.1 28 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0370863264824022 0.0865561703967242 1.52095834139837 0.303030303030303 28.1 28 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0101818478273812 0.0307617185952514 1.51521887595913 0.30188679245283 28.1 28 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.0496094834147991 0.111476124370908 1.50574875798439 0.3 28.1 28 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00385411124952155 0.0137453641806245 1.50574875798439 0.3 28.1 28 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.100545986251304 0.198442355666582 1.50574875798439 0.3 28.1 28 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.100545986251304 0.198442355666582 1.50574875798439 0.3 28.1 28 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.000229950166185037 0.00122096674060189 1.49330455337294 0.297520661157025 28.1 28 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 4.5836534155028e-06 4.00155755230705e-05 1.49006387508872 0.296875 28.1 28 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 9.61441290527238e-07 1.02224717121779e-05 1.48549204823572 0.295964125560538 28.1 28 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.00859660411214097 0.0266051015012889 1.48106435211579 0.295081967213115 28.1 28 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.138172126347478 0.25904998128124 1.47622427253371 0.294117647058824 28.1 28 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.138172126347478 0.25904998128124 1.47622427253371 0.294117647058824 28.1 28 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.138172126347478 0.25904998128124 1.47622427253371 0.294117647058824 28.1 28 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.1602740627719e-05 8.68984205960217e-05 1.47301508933255 0.293478260869565 28.1 28 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0307362200985226 0.0742574553483832 1.46902317852135 0.292682926829268 28.1 28 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0898598897059232 0.181892778167182 1.46392240359593 0.291666666666667 28.1 28 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0898598897059232 0.181892778167182 1.46392240359593 0.291666666666667 28.1 28 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.0147175152848949 0.0410647534321675 1.46012000774243 0.290909090909091 28.1 28 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0147175152848949 0.0410647534321675 1.46012000774243 0.290909090909091 28.1 28 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0147175152848949 0.0410647534321675 1.46012000774243 0.290909090909091 28.1 28 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.0147175152848949 0.0410647534321675 1.46012000774243 0.290909090909091 28.1 28 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.32658350217991e-15 7.55091329440804e-14 1.45969423402323 0.290824261275272 28.1 28 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.0027570243143148 0.0101049561240245 1.45905887401588 0.290697674418605 28.1 28 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 7.89230789016811e-05 0.000482006614923143 1.45717621740424 0.290322580645161 28.1 28 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0102725734529243 0.0308393924546653 1.45717621740424 0.290322580645161 28.1 28 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0599674470686693 0.128902835617396 1.45717621740424 0.290322580645161 28.1 28 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.07797569964035e-05 8.24709365907647e-05 1.45224499501032 0.289340101522843 28.1 28 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.91187847336072e-11 1.79220591476726e-09 1.45173086532127 0.289237668161435 28.1 28 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0134071817042732 0.0385422617478399 1.4461993720754 0.288135593220339 28.1 28 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0134071817042732 0.0385422617478399 1.4461993720754 0.288135593220339 28.1 28 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0134071817042732 0.0385422617478399 1.4461993720754 0.288135593220339 28.1 28 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00937115675777629 0.0284939232186232 1.44491042432845 0.287878787878788 28.1 28 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.121904724612912 0.235693509679584 1.43404643617561 0.285714285714286 28.1 28 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.121904724612912 0.235693509679584 1.43404643617561 0.285714285714286 28.1 28 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0539075741965333 0.119300899038362 1.43404643617561 0.285714285714286 28.1 28 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0539075741965333 0.119300899038362 1.43404643617561 0.285714285714286 28.1 28 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0110883261751291 0.0328722669733514 1.42334459709967 0.283582089552239 28.1 28 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0110883261751291 0.0328722669733514 1.42334459709967 0.283582089552239 28.1 28 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.0158820361230456 0.0431300332120112 1.42209604920748 0.283333333333333 28.1 28 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.0158820361230456 0.0431300332120112 1.42209604920748 0.283333333333333 28.1 28 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0716103850356589 0.149635209846906 1.41163946061036 0.28125 28.1 28 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.107719267481459 0.210555656079829 1.40536550745209 0.28 28.1 28 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.107719267481459 0.210555656079829 1.40536550745209 0.28 28.1 28 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.107719267481459 0.210555656079829 1.40536550745209 0.28 28.1 28 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.107719267481459 0.210555656079829 1.40536550745209 0.28 28.1 28 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0434907020280936 0.100793597697031 1.40069651905524 0.27906976744186 28.1 28 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00122222453020115 0.00519645036314142 1.39878299922047 0.278688524590164 28.1 28 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.026933891621352 0.0677068207278293 1.39421181294851 0.277777777777778 28.1 28 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.16655946274514 0.305037471668383 1.39421181294851 0.277777777777778 28.1 28 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.16655946274514 0.305037471668383 1.39421181294851 0.277777777777778 28.1 28 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.16655946274514 0.305037471668383 1.39421181294851 0.277777777777778 28.1 28 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.16655946274514 0.305037471668383 1.39421181294851 0.277777777777778 28.1 28 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.16655946274514 0.305037471668383 1.39421181294851 0.277777777777778 28.1 28 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0168976038444432 0.0454542349161488 1.38992193044713 0.276923076923077 28.1 28 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 4.04554866421513e-05 0.000266519247647136 1.38624488830309 0.276190476190476 28.1 28 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00309886655915923 0.0112205778974137 1.38624488830309 0.276190476190476 28.1 28 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000280130655910678 0.00146553648294447 1.3856583662433 0.276073619631902 28.1 28 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.0242759633869572 0.0614674304264058 1.3845965590661 0.275862068965517 28.1 28 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.0152683297037497 0.0417021749874009 1.38208823196634 0.27536231884058 28.1 28 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.0152683297037497 0.0417021749874009 1.38208823196634 0.27536231884058 28.1 28 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.000453446496148074 0.0021799133919551 1.37467508690719 0.273885350318471 28.1 28 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.10338435069233e-05 8.30749169859889e-05 1.37429450133496 0.273809523809524 28.1 28 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.10338435069233e-05 8.30749169859889e-05 1.37429450133496 0.273809523809524 28.1 28 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.10338435069233e-05 8.30749169859889e-05 1.37429450133496 0.273809523809524 28.1 28 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.000412720489048947 0.00204634583943084 1.37169659112449 0.273291925465839 28.1 28 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.145282795513077 0.272022918440932 1.36886250725853 0.272727272727273 28.1 28 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.000476711763170758 0.00228404322892926 1.36322932821632 0.271604938271605 28.1 28 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0177753086850095 0.0473675360651095 1.36234411436683 0.271428571428571 28.1 28 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0456908067122614 0.105548730440825 1.35935651762479 0.270833333333333 28.1 28 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0409027918919677 0.0949505266921207 1.35131298793471 0.269230769230769 28.1 28 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0668067351681465 0.141467238309929 1.34660458031124 0.268292682926829 28.1 28 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00239372964246401 0.00906374682733212 1.32860184528034 0.264705882352941 28.1 28 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00216691120454816 0.00873479090071457 1.32649295346244 0.264285714285714 28.1 28 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00115509620651763 0.00498091485416542 1.32581651646424 0.264150943396226 28.1 28 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00115509620651763 0.00498091485416542 1.32581651646424 0.264150943396226 28.1 28 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.196995994963605 0.342138455649894 1.32083224384595 0.263157894736842 28.1 28 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00273671690864675 0.0101049561240245 1.31890402159216 0.262773722627737 28.1 28 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00273671690864675 0.0101049561240245 1.31890402159216 0.262773722627737 28.1 28 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0774811210893495 0.159559530115983 1.31454256649431 0.261904761904762 28.1 28 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00282156467615753 0.0102687635145068 1.30780995411789 0.26056338028169 28.1 28 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.061215174737413 0.131363725716038 1.3049822569198 0.26 28.1 28 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0486418776182758 0.109868875953661 1.29805927412447 0.258620689655172 28.1 28 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0486418776182758 0.109868875953661 1.29805927412447 0.258620689655172 28.1 28 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0486418776182758 0.109868875953661 1.29805927412447 0.258620689655172 28.1 28 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00236873519698696 0.00906374682733212 1.29526774880377 0.258064516129032 28.1 28 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.130083668908609 0.247605696079217 1.29526774880377 0.258064516129032 28.1 28 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.130083668908609 0.247605696079217 1.29526774880377 0.258064516129032 28.1 28 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.100842961133434 0.198477916587659 1.28696475041401 0.256410256410256 28.1 28 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.100842961133434 0.198477916587659 1.28696475041401 0.256410256410256 28.1 28 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00179169192598399 0.0074115628217303 1.28397180913397 0.255813953488372 28.1 28 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0891653276416562 0.181001799192691 1.28397180913397 0.255813953488372 28.1 28 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.85684050382625e-08 4.1063475120654e-07 1.28335854445838 0.25569176882662 28.1 28 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0201365816967764 0.0520988286445688 1.28267486791263 0.255555555555556 28.1 28 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.0790160897754054 0.162250931818762 1.28148830466756 0.25531914893617 28.1 28 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0283757225583527 0.0701018284731527 1.26990859107117 0.253012048192771 28.1 28 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0562561159938978 0.124305051334343 1.25479063165366 0.25 28.1 28 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0901245174631202 0.182169301633551 1.25479063165366 0.25 28.1 28 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.171341863962278 0.31218882511949 1.25479063165366 0.25 28.1 28 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.197396818052398 0.342138455649894 1.25479063165366 0.25 28.1 28 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.197396818052398 0.342138455649894 1.25479063165366 0.25 28.1 28 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.197396818052398 0.342138455649894 1.25479063165366 0.25 28.1 28 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.197396818052398 0.342138455649894 1.25479063165366 0.25 28.1 28 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.197396818052398 0.342138455649894 1.25479063165366 0.25 28.1 28 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.229145997867705 0.390955050468738 1.25479063165366 0.25 28.1 28 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.84335848660495e-17 2.6973994176259e-15 1.24425978710136 0.247901872175597 28.1 28 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.090479301010064 0.182368336171843 1.23111533671679 0.245283018867925 28.1 28 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.090479301010064 0.182368336171843 1.23111533671679 0.245283018867925 28.1 28 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0325750755386172 0.0783450742049254 1.22809295863975 0.24468085106383 28.1 28 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.17038047762566 0.311234171580634 1.2167666731187 0.242424242424242 28.1 28 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.17038047762566 0.311234171580634 1.2167666731187 0.242424242424242 28.1 28 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.195519636255701 0.341379683916396 1.21152198918284 0.241379310344828 28.1 28 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0567874141340683 0.125284481105084 1.20714035450225 0.240506329113924 28.1 28 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.28024253907028e-05 9.43930120775651e-05 1.20662695084271 0.24040404040404 28.1 28 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.225716044548484 0.386514959557754 1.20459900638751 0.24 28.1 28 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.147848040109125 0.276462235315748 1.195038696813 0.238095238095238 28.1 28 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.262658895759828 0.435114794722043 1.195038696813 0.238095238095238 28.1 28 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.192402494605772 0.341262064366642 1.18097941802697 0.235294117647059 28.1 28 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.192402494605772 0.341262064366642 1.18097941802697 0.235294117647059 28.1 28 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.192402494605772 0.341262064366642 1.18097941802697 0.235294117647059 28.1 28 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.220941955101923 0.382482241009776 1.17113792287674 0.233333333333333 28.1 28 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00433954509701395 0.0153230091142701 1.16129642772652 0.231372549019608 28.1 28 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.255235949774961 0.430332649916788 1.1582682753726 0.230769230769231 28.1 28 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.255235949774961 0.430332649916788 1.1582682753726 0.230769230769231 28.1 28 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.255235949774961 0.430332649916788 1.1582682753726 0.230769230769231 28.1 28 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0845859996293999 0.172691359358158 1.14071875604878 0.227272727272727 28.1 28 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0592955987718243 0.128227589634415 1.14071875604878 0.227272727272727 28.1 28 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.247442288574973 0.419179019812126 1.1333592802033 0.225806451612903 28.1 28 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0831880559419402 0.170081327019225 1.1333592802033 0.225806451612903 28.1 28 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.179977634437785 0.323777716567596 1.12675077128083 0.224489795918367 28.1 28 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.179977634437785 0.323777716567596 1.12675077128083 0.224489795918367 28.1 28 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.285714199235517 0.465184560082541 1.1153694503588 0.222222222222222 28.1 28 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.285714199235517 0.465184560082541 1.1153694503588 0.222222222222222 28.1 28 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.285714199235517 0.465184560082541 1.1153694503588 0.222222222222222 28.1 28 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.285714199235517 0.465184560082541 1.1153694503588 0.222222222222222 28.1 28 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.170959025983852 0.31189063330131 1.10591716688119 0.220338983050847 28.1 28 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.274845195586746 0.449545647494184 1.09794180269695 0.21875 28.1 28 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.192606926378882 0.341262064366642 1.09509000580683 0.218181818181818 28.1 28 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.332367026024111 0.518026591492124 1.09112228839448 0.217391304347826 28.1 28 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0217132085611887 0.0557723750587933 1.088493078061 0.216867469879518 28.1 28 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.316906654310037 0.502740433760516 1.0755348271317 0.214285714285714 28.1 28 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.101062561241387 0.198635393158141 1.06706604896531 0.21259842519685 28.1 28 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.302970311960884 0.48604547651733 1.06467083897886 0.212121212121212 28.1 28 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.237167722690209 0.402252287709378 1.06174591909155 0.211538461538462 28.1 28 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.237167722690209 0.402252287709378 1.06174591909155 0.211538461538462 28.1 28 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.0726694764661228 0.151625608520957 1.04565885971138 0.208333333333333 28.1 28 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.267715747529853 0.442461682619025 1.04565885971138 0.208333333333333 28.1 28 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.267715747529853 0.442461682619025 1.04565885971138 0.208333333333333 28.1 28 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.367885501806141 0.571229917308953 1.04565885971138 0.208333333333333 28.1 28 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.316495992311223 0.502649327074632 1.0295718003312 0.205128205128205 28.1 28 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.248369968533117 0.420250255912753 1.01838080250152 0.202898550724638 28.1 28 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.231127546619208 0.392944443057506 1.01653924589663 0.20253164556962 28.1 28 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.380480552390654 0.585323055191244 1.00383250532292 0.2 28.1 28 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.380480552390654 0.585323055191244 1.00383250532292 0.2 28.1 28 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.308676652153261 0.491413234086005 0.98737623474386 0.19672131147541 28.1 28 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.352489395756327 0.548188426405742 0.982010059555034 0.195652173913043 28.1 28 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.370115238059631 0.571229917308953 0.979348785680901 0.195121951219512 28.1 28 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.389876369423113 0.593426556850638 0.975948269063954 0.194444444444444 28.1 28 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.412409735706416 0.610771362671947 0.97145081160283 0.193548387096774 28.1 28 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.397219268400231 0.598140760776221 0.956030957450404 0.19047619047619 28.1 28 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.419109505052826 0.610771362671947 0.949571288818982 0.189189189189189 28.1 28 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.372430452869542 0.574180427338416 0.941092973740241 0.1875 28.1 28 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.444155398810955 0.643618261209765 0.941092973740241 0.1875 28.1 28 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.473483804929176 0.67851707393174 0.92947454196567 0.185185185185185 28.1 28 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.3816821442134 0.58653746351584 0.924582570692167 0.184210526315789 28.1 28 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0228633501792754 0.0585153728509153 0.915691114611643 0.182439024390244 28.1 28 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.410130410282138 0.610771362671947 0.898165925815248 0.178947368421053 28.1 28 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.478145284200971 0.684507786134791 0.892295560287044 0.177777777777778 28.1 28 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.446273212870967 0.646029279669773 0.879647040746892 0.175257731958763 28.1 28 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.504599155452476 0.708120090359543 0.872897830715586 0.173913043478261 28.1 28 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.528399608753965 0.723688780805478 0.852310617727011 0.169811320754717 28.1 28 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.509846368642768 0.708120090359543 0.841048855811099 0.167567567567568 28.1 28 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.552465253860252 0.755195058831065 0.836527087769103 0.166666666666667 28.1 28 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.556110603537464 0.756544348789495 0.836527087769103 0.166666666666667 28.1 28 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.556110603537464 0.756544348789495 0.836527087769103 0.166666666666667 28.1 28 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.571775905666877 0.771220013046413 0.822813528953216 0.163934426229508 28.1 28 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.580997578495453 0.782916244506656 0.81945510638606 0.163265306122449 28.1 28 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.637361966405574 0.835913436124546 0.780758615251163 0.155555555555556 28.1 28 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.661111164760762 0.858780747003223 0.760479170699185 0.151515151515152 28.1 28 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.792637009040237 0.980802142490659 0.747953631417081 0.149019607843137 28.1 28 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.687791666858883 0.884925444792216 0.738112136266856 0.147058823529412 28.1 28 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.763994822405349 0.95567123466071 0.723917672107878 0.144230769230769 28.1 28 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.773739505368696 0.959922681900309 0.708587650816182 0.141176470588235 28.1 28 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.773739505368696 0.959922681900309 0.708587650816182 0.141176470588235 28.1 28 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.841067866169123 1 0.703906939708148 0.140243902439024 28.1 28 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.741313146210048 0.936014735631675 0.700348259527621 0.13953488372093 28.1 28 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.779826500186452 0.966631628715436 0.660416121922976 0.131578947368421 28.1 28 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.858489343143197 1 0.659081947939294 0.131313131313131 28.1 28 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.845695301810189 1 0.614591329789545 0.122448979591837 28.1 28 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.925178009442791 1 0.571803325816855 0.113924050632911 28.1 28 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.991832415512649 1 0.555114749487331 0.110599078341014 28.1 28 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.918783852168319 1 0.52282942985569 0.104166666666667 28.1 28 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.918783852168319 1 0.52282942985569 0.104166666666667 28.1 28 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999999997 1 0.450923921366721 0.089840470193115 28.1 28 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.970539077908757 1 0.440277414615317 0.087719298245614 28.1 28 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999998960210843 1 0.426887534480109 0.0850515463917526 28.1 28 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.985700741777558 1 0.398346232271002 0.0793650793650794 28.1 28 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.37666409557777 0.0750452079566004 28.1 28 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.994794649397318 1 0.353462149761593 0.0704225352112676 28.1 28 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.99999972866276 1 0.340586028591706 0.0678571428571429 28.1 28 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999990305636164 1 0.323816937200943 0.0645161290322581 28.1 28 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999999169259 1 0.142589844506097 0.0284090909090909 28.1 28 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0890496577302594 0.017741935483871 28.1 28 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 3.78264557874927e-05 0.00019292848238567 3.28171147292692 1 28.2 28 2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.000694213067988926 0.00262730105252192 3.28171147292692 1 28.2 28 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.000694213067988926 0.00262730105252192 3.28171147292692 1 28.2 28 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.000694213067988926 0.00262730105252192 3.28171147292692 1 28.2 28 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 6.69589028896892e-08 7.00606755970792e-07 3.047303510575 0.928571428571429 28.2 28 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 1.05822321239475e-06 7.96746894834781e-06 3.00823551684968 0.916666666666667 28.2 28 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 1.62760904632034e-05 8.73995348269373e-05 2.95354032563423 0.9 28.2 28 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 6.2973572754901e-05 0.000306888335719946 2.91707686482393 0.888888888888889 28.2 28 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000240812561236506 0.00102291425265537 2.87149753881106 0.875 28.2 28 2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00335499817084868 0.0104012252660516 2.73475956077243 0.833333333333333 28.2 28 2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00335499817084868 0.0104012252660516 2.73475956077243 0.833333333333333 28.2 28 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00335499817084868 0.0104012252660516 2.73475956077243 0.833333333333333 28.2 28 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 7.07684199346293e-05 0.000337931079083817 2.68503665966748 0.818181818181818 28.2 28 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.000249763501921692 0.00105151912199576 2.62536917834154 0.8 28.2 28 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 5.7605058273868e-06 3.38727264147579e-05 2.62536917834154 0.8 28.2 28 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.000863249020922121 0.00317416888054826 2.55244225672094 0.777777777777778 28.2 28 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.000863249020922121 0.00317416888054826 2.55244225672094 0.777777777777778 28.2 28 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 6.73716848630184e-05 0.000322794301549075 2.52439344071302 0.769230769230769 28.2 28 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 5.48576348540377e-06 3.239104331838e-05 2.50954406753235 0.764705882352941 28.2 28 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.27228658874181e-07 1.19109461564447e-06 2.46128360469519 0.75 28.2 28 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 1.81049802071931e-05 9.577467224846e-05 2.46128360469519 0.75 28.2 28 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 1.81049802071931e-05 9.577467224846e-05 2.46128360469519 0.75 28.2 28 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 1.81049802071931e-05 9.577467224846e-05 2.46128360469519 0.75 28.2 28 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.000223946717472482 0.000959868008925728 2.46128360469519 0.75 28.2 28 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000223946717472482 0.000959868008925728 2.46128360469519 0.75 28.2 28 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.000223946717472482 0.000959868008925728 2.46128360469519 0.75 28.2 28 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0029072967050659 0.00923456073952853 2.46128360469519 0.75 28.2 28 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0029072967050659 0.00923456073952853 2.46128360469519 0.75 28.2 28 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0029072967050659 0.00923456073952853 2.46128360469519 0.75 28.2 28 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0029072967050659 0.00923456073952853 2.46128360469519 0.75 28.2 28 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0029072967050659 0.00923456073952853 2.46128360469519 0.75 28.2 28 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 9.72024854906341e-09 1.21332576186993e-07 2.40658841347974 0.733333333333333 28.2 28 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 5.86660646930153e-05 0.000286879072364814 2.40658841347974 0.733333333333333 28.2 28 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 5.86660646930153e-05 0.000286879072364814 2.40658841347974 0.733333333333333 28.2 28 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 5.86660646930153e-05 0.000286879072364814 2.40658841347974 0.733333333333333 28.2 28 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 1.31227041711216e-06 9.67544457798239e-06 2.38669925303776 0.727272727272727 28.2 28 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.000727083720553859 0.00270459625018533 2.38669925303776 0.727272727272727 28.2 28 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000727083720553859 0.00270459625018533 2.38669925303776 0.727272727272727 28.2 28 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.000727083720553859 0.00270459625018533 2.38669925303776 0.727272727272727 28.2 28 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.000727083720553859 0.00270459625018533 2.38669925303776 0.727272727272727 28.2 28 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.5451449064696e-07 2.83412427073384e-06 2.36283226050738 0.72 28.2 28 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000186129259875012 0.000809975341902576 2.34407962351923 0.714285714285714 28.2 28 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000186129259875012 0.000809975341902576 2.34407962351923 0.714285714285714 28.2 28 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00947390960498577 0.0256299873914349 2.34407962351923 0.714285714285714 28.2 28 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00947390960498577 0.0256299873914349 2.34407962351923 0.714285714285714 28.2 28 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00947390960498577 0.0256299873914349 2.34407962351923 0.714285714285714 28.2 28 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.00947390960498577 0.0256299873914349 2.34407962351923 0.714285714285714 28.2 28 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00947390960498577 0.0256299873914349 2.34407962351923 0.714285714285714 28.2 28 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.00947390960498577 0.0256299873914349 2.34407962351923 0.714285714285714 28.2 28 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00947390960498577 0.0256299873914349 2.34407962351923 0.714285714285714 28.2 28 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 4.1208055888147e-06 2.54960049017258e-05 2.34407962351923 0.714285714285714 28.2 28 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 4.83911003394873e-05 0.000241615915028388 2.31650221618371 0.705882352941177 28.2 28 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.92915462232724e-09 2.88967055533859e-08 2.30606752151622 0.702702702702703 28.2 28 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 5.26233602703277e-10 9.85303179798372e-09 2.29719803104885 0.7 28.2 28 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 1.2720210238692e-05 6.93519508416045e-05 2.29719803104885 0.7 28.2 28 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 1.2720210238692e-05 6.93519508416045e-05 2.29719803104885 0.7 28.2 28 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 1.2720210238692e-05 6.93519508416045e-05 2.29719803104885 0.7 28.2 28 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00229471523192312 0.00755874947922824 2.29719803104885 0.7 28.2 28 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00229471523192312 0.00755874947922824 2.29719803104885 0.7 28.2 28 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00229471523192312 0.00755874947922824 2.29719803104885 0.7 28.2 28 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.00229471523192312 0.00755874947922824 2.29719803104885 0.7 28.2 28 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 7.97661728183701e-08 7.99346929017891e-07 2.29719803104884 0.7 28.2 28 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 9.15470939490357e-20 6.85639550997252e-18 2.2895661439025 0.697674418604651 28.2 28 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.000576240540843776 0.00222219590683115 2.27195409664172 0.692307692307692 28.2 28 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000576240540843776 0.00222219590683115 2.27195409664172 0.692307692307692 28.2 28 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000576240540843776 0.00222219590683115 2.27195409664172 0.692307692307692 28.2 28 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.17917463375975e-10 2.54237197551535e-09 2.26073457023855 0.688888888888889 28.2 28 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000147900450561823 0.000655645922584033 2.25617663763726 0.6875 28.2 28 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 1.0139095242463e-05 5.63180859369792e-05 2.2375305497229 0.681818181818182 28.2 28 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.68979304139229e-06 1.76385967645218e-05 2.23156380159031 0.68 28.2 28 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.68979304139229e-06 1.76385967645218e-05 2.23156380159031 0.68 28.2 28 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000114180886334046 0.000517450322462891 2.18780764861795 0.666666666666667 28.2 28 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000114180886334046 0.000517450322462891 2.18780764861795 0.666666666666667 28.2 28 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00173335772671661 0.00600138210490935 2.18780764861795 0.666666666666667 28.2 28 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00699539207335347 0.0197117681591723 2.18780764861795 0.666666666666667 28.2 28 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00699539207335347 0.0197117681591723 2.18780764861795 0.666666666666667 28.2 28 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 5.63548368639757e-07 4.38212747854849e-06 2.18780764861795 0.666666666666667 28.2 28 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 6.38633814321926e-10 1.13596989722513e-08 2.16453309916457 0.659574468085106 28.2 28 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.18264953423293e-08 3.48377714401035e-07 2.15902070587297 0.657894736842105 28.2 28 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.36806520006531e-21 2.24650451979529e-19 2.15824268039338 0.657657657657658 28.2 28 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 8.58620497854265e-21 7.63635605279137e-19 2.15742143127603 0.657407407407407 28.2 28 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 1.17665691925795e-07 1.11625519740271e-06 2.15655325363769 0.657142857142857 28.2 28 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 1.17665691925795e-07 1.11625519740271e-06 2.15655325363769 0.657142857142857 28.2 28 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.09503306800096e-17 3.36541068525512e-15 2.15008682709005 0.655172413793103 28.2 28 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.62410699309942e-06 1.13847500058151e-05 2.15008682709005 0.655172413793103 28.2 28 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 4.20665887164978e-18 2.49419815598235e-16 2.14174854022599 0.652631578947368 28.2 28 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 4.20665887164978e-18 2.49419815598235e-16 2.14174854022599 0.652631578947368 28.2 28 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 8.6438090200624e-05 0.000408642532742485 2.1331124574025 0.65 28.2 28 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.55536049736217e-16 6.9164937117074e-15 2.12565402223676 0.647727272727273 28.2 28 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000330334259302774 0.00135465605472002 2.12346036483507 0.647058823529412 28.2 28 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.53351587499344e-18 1.63872413187076e-16 2.12151044714468 0.646464646464647 28.2 28 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 6.45338870564184e-05 0.000313418843963425 2.08836184640804 0.636363636363636 28.2 28 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00503807037681935 0.0148396241421429 2.08836184640804 0.636363636363636 28.2 28 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00503807037681935 0.0148396241421429 2.08836184640804 0.636363636363636 28.2 28 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00503807037681935 0.0148396241421429 2.08836184640804 0.636363636363636 28.2 28 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00503807037681935 0.0148396241421429 2.08836184640804 0.636363636363636 28.2 28 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00503807037681935 0.0148396241421429 2.08836184640804 0.636363636363636 28.2 28 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 8.11329695487689e-10 1.40795384960851e-08 2.08262458858824 0.634615384615385 28.2 28 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 5.21233525933437e-08 5.53518886121851e-07 2.08108532429512 0.634146341463415 28.2 28 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 5.21233525933437e-08 5.53518886121851e-07 2.08108532429512 0.634146341463415 28.2 28 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.66220150575975e-11 1.05306551471367e-09 2.07841726618705 0.633333333333333 28.2 28 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.66220150575975e-11 1.05306551471367e-09 2.07841726618705 0.633333333333333 28.2 28 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.66220150575975e-11 1.05306551471367e-09 2.07841726618705 0.633333333333333 28.2 28 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.66220150575975e-11 1.05306551471367e-09 2.07841726618705 0.633333333333333 28.2 28 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.66220150575975e-11 1.05306551471367e-09 2.07841726618705 0.633333333333333 28.2 28 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.66220150575975e-11 1.05306551471367e-09 2.07841726618705 0.633333333333333 28.2 28 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.66220150575975e-11 1.05306551471367e-09 2.07841726618705 0.633333333333333 28.2 28 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 2.95235834919746e-09 4.0788407096194e-08 2.07618480940275 0.63265306122449 28.2 28 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.48461890836021e-16 6.81487969869862e-15 2.07265987763806 0.631578947368421 28.2 28 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000243882745948923 0.00102980755930361 2.07265987763806 0.631578947368421 28.2 28 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.28151192144307e-05 6.96027276417362e-05 2.06626277925028 0.62962962962963 28.2 28 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 7.00473087453347e-07 5.35899571745222e-06 2.06279006869692 0.628571428571429 28.2 28 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.99446312704757e-18 2.73350808838027e-16 2.05490344566452 0.626168224299065 28.2 28 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 4.76935358043965e-05 0.000239398678812808 2.05106967057933 0.625 28.2 28 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000929647649700975 0.00334908507727718 2.05106967057933 0.625 28.2 28 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000929647649700975 0.00334908507727718 2.05106967057933 0.625 28.2 28 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.000929647649700975 0.00334908507727718 2.05106967057933 0.625 28.2 28 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000929647649700975 0.00334908507727718 2.05106967057933 0.625 28.2 28 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0204182644381855 0.0481046196945993 2.05106967057933 0.625 28.2 28 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 1.06326893913514e-07 1.02927326557095e-06 2.03153567371667 0.619047619047619 28.2 28 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000178281580026662 0.000780599041162893 2.03153567371667 0.619047619047619 28.2 28 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000178281580026662 0.000780599041162893 2.03153567371667 0.619047619047619 28.2 28 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.90527465338364e-06 1.32253943012923e-05 2.02693943916075 0.617647058823529 28.2 28 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.90527465338364e-06 1.32253943012923e-05 2.02693943916075 0.617647058823529 28.2 28 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.17884069148187e-08 2.44133094801472e-07 2.02488580244427 0.617021276595745 28.2 28 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.17884069148187e-08 2.44133094801472e-07 2.02488580244427 0.617021276595745 28.2 28 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.10115556891985e-12 8.48643148956335e-11 2.02297282577687 0.616438356164384 28.2 28 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.81639230202078e-13 1.48994048821208e-11 2.01004827716774 0.6125 28.2 28 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.40279109432734e-06 1.00797937528992e-05 2.00549034456645 0.611111111111111 28.2 28 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000670003845396487 0.0025698530242566 2.00549034456645 0.611111111111111 28.2 28 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.1920808104395e-08 1.40192644070695e-07 1.99476579726931 0.607843137254902 28.2 28 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.1920808104395e-08 1.40192644070695e-07 1.99476579726931 0.607843137254902 28.2 28 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 2.55058431820308e-05 0.000132948039736373 1.99246767999135 0.607142857142857 28.2 28 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.30057464610924e-32 2.05635302379272e-30 1.98668631769119 0.605381165919282 28.2 28 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 4.27301872595504e-08 4.64160736414811e-07 1.98270068156002 0.604166666666667 28.2 28 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.52985679897665e-07 1.39550399034857e-06 1.96902688375615 0.6 28.2 28 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 3.71247700227905e-06 2.31704156765047e-05 1.96902688375615 0.6 28.2 28 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000480049729571374 0.00188704631265211 1.96902688375615 0.6 28.2 28 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000480049729571374 0.00188704631265211 1.96902688375615 0.6 28.2 28 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.014046407335499 0.0345813799972579 1.96902688375615 0.6 28.2 28 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 9.34480597486186e-05 0.000435988816466506 1.96902688375615 0.6 28.2 28 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 9.34480597486186e-05 0.000435988816466506 1.96902688375615 0.6 28.2 28 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 9.34480597486186e-05 0.000435988816466506 1.96902688375615 0.6 28.2 28 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00253451864111037 0.00825313507162483 1.96902688375615 0.6 28.2 28 2 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.00253451864111037 0.00825313507162483 1.96902688375615 0.6 28.2 28 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.01640001664991e-10 4.04132003337016e-09 1.95923073010562 0.597014925373134 28.2 28 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.47662549981816e-10 3.00176869463034e-09 1.95000246942034 0.594202898550725 28.2 28 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 6.72197569189632e-05 0.000322794301549075 1.94471790988262 0.592592592592593 28.2 28 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 6.72197569189632e-05 0.000322794301549075 1.94471790988262 0.592592592592593 28.2 28 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 6.72197569189632e-05 0.000322794301549075 1.94471790988262 0.592592592592593 28.2 28 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.97189622790907e-07 3.12265653719039e-06 1.93919314309318 0.590909090909091 28.2 28 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000342583803205904 0.00139284786274858 1.93919314309318 0.590909090909091 28.2 28 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00178580963598412 0.00615304385473464 1.93041851348642 0.588235294117647 28.2 28 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00178580963598412 0.00615304385473464 1.93041851348642 0.588235294117647 28.2 28 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.09846903650705e-38 3.12624287789906e-36 1.92646543803219 0.587030716723549 28.2 28 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.80062494046452e-14 2.01324129031244e-12 1.92261884272486 0.585858585858586 28.2 28 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 8.76108726761331e-23 1.03891893181781e-20 1.92242269715837 0.585798816568047 28.2 28 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.40961275954107e-06 1.00797937528992e-05 1.92100183781088 0.585365853658537 28.2 28 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.40961275954107e-06 1.00797937528992e-05 1.92100183781088 0.585365853658537 28.2 28 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00966466808696315 0.0256953616160428 1.9143316925407 0.583333333333333 28.2 28 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00966466808696315 0.0256953616160428 1.9143316925407 0.583333333333333 28.2 28 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00966466808696315 0.0256953616160428 1.9143316925407 0.583333333333333 28.2 28 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00966466808696315 0.0256953616160428 1.9143316925407 0.583333333333333 28.2 28 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.00966466808696315 0.0256953616160428 1.9143316925407 0.583333333333333 28.2 28 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 6.94603727341147e-06 4.00170487452005e-05 1.9143316925407 0.583333333333333 28.2 28 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.05630754006235e-21 1.0736611639348e-19 1.912653925939 0.582822085889571 28.2 28 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 8.57702350300802e-34 1.52563805559755e-31 1.91118829074671 0.582375478927203 28.2 28 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.61762571509073e-22 1.77067799428777e-20 1.91111432835156 0.582352941176471 28.2 28 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 3.44988914078169e-05 0.000177227156943406 1.90550988750595 0.580645161290323 28.2 28 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 4.98751604224413e-06 2.99461406249511e-05 1.89993822116822 0.578947368421053 28.2 28 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 5.05398516395767e-10 9.58909451774901e-09 1.89507282239442 0.577464788732394 28.2 28 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 4.20715590698713e-17 2.0644078812561e-15 1.89329508053476 0.576923076923077 28.2 28 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 2.46431038221002e-05 0.000128923296834002 1.88947024198823 0.575757575757576 28.2 28 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.64544633220147e-52 1.25482337690757e-49 1.88736927433591 0.575117370892019 28.2 28 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.5755226467528e-06 2.24139591468248e-05 1.88698409693298 0.575 28.2 28 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.16516165286567e-08 1.39329834624189e-07 1.88294920577774 0.573770491803279 28.2 28 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.16516165286567e-08 1.39329834624189e-07 1.88294920577774 0.573770491803279 28.2 28 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.63878804600833e-10 5.14382930064363e-09 1.88151457781144 0.573333333333333 28.2 28 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000122838308568206 0.000549682116643263 1.87526369881538 0.571428571428571 28.2 28 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000122838308568206 0.000549682116643263 1.87526369881538 0.571428571428571 28.2 28 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00665981772748063 0.0188407964735685 1.87526369881538 0.571428571428571 28.2 28 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 2.55987528461572e-06 1.69428024651543e-05 1.87526369881538 0.571428571428571 28.2 28 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000882407262297655 0.00321965521602452 1.87526369881538 0.571428571428571 28.2 28 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000882407262297655 0.00321965521602452 1.87526369881538 0.571428571428571 28.2 28 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000882407262297655 0.00321965521602452 1.87526369881538 0.571428571428571 28.2 28 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 8.39087269834218e-09 1.06609034372687e-07 1.87526369881538 0.571428571428571 28.2 28 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 7.31474286876007e-14 2.42066955866176e-12 1.87088224157516 0.570093457943925 28.2 28 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 9.08678313822658e-10 1.50354562856935e-08 1.86875236652783 0.569444444444444 28.2 28 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.44548027469686e-62 6.32591843089363e-59 1.86545956350789 0.568441064638783 28.2 28 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.33953039150662e-09 5.71773309917956e-08 1.86126919360034 0.567164179104478 28.2 28 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 6.40911398166972e-16 2.76368763512607e-14 1.8604978429192 0.566929133858268 28.2 28 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.30799303975319e-06 9.67544457798239e-06 1.8548803977413 0.565217391304348 28.2 28 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.30799303975319e-06 9.67544457798239e-06 1.8548803977413 0.565217391304348 28.2 28 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.18004942725578e-15 7.95438547432044e-14 1.85257905729746 0.564516129032258 28.2 28 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.18004942725578e-15 7.95438547432044e-14 1.85257905729746 0.564516129032258 28.2 28 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.18004942725578e-15 7.95438547432044e-14 1.85257905729746 0.564516129032258 28.2 28 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 2.0739980063065e-08 2.36103933037932e-07 1.85257905729746 0.564516129032258 28.2 28 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.0739980063065e-08 2.36103933037932e-07 1.85257905729746 0.564516129032258 28.2 28 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.38702978650926e-07 1.28165154948226e-06 1.84969192110427 0.563636363636364 28.2 28 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.23725580198409e-09 3.24858674104424e-08 1.84885153404334 0.563380281690141 28.2 28 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 9.3379317908077e-07 7.10581654455581e-06 1.84596270352139 0.5625 28.2 28 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00459792420149387 0.0138619621583173 1.84596270352139 0.5625 28.2 28 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00459792420149387 0.0138619621583173 1.84596270352139 0.5625 28.2 28 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00459792420149387 0.0138619621583173 1.84596270352139 0.5625 28.2 28 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00459792420149387 0.0138619621583173 1.84596270352139 0.5625 28.2 28 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.15043616373689e-09 1.79897874834901e-08 1.83775842483908 0.56 28.2 28 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.15043616373689e-09 1.79897874834901e-08 1.83775842483908 0.56 28.2 28 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.15043616373689e-09 1.79897874834901e-08 1.83775842483908 0.56 28.2 28 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.15043616373689e-09 1.79897874834901e-08 1.83775842483908 0.56 28.2 28 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.15043616373689e-09 1.79897874834901e-08 1.83775842483908 0.56 28.2 28 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.07691845928376e-12 5.79500974031528e-11 1.83775842483908 0.56 28.2 28 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.24983343353435e-10 2.61546025870497e-09 1.83619570509006 0.55952380952381 28.2 28 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.24983343353435e-10 2.61546025870497e-09 1.83619570509006 0.55952380952381 28.2 28 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 7.09152583609585e-08 7.31249367011913e-07 1.83553353570489 0.559322033898305 28.2 28 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 7.09152583609585e-08 7.31249367011913e-07 1.83553353570489 0.559322033898305 28.2 28 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 4.50977787213869e-06 2.73435475542867e-05 1.831652915122 0.558139534883721 28.2 28 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 5.06628035442049e-08 5.4616037457124e-07 1.82915065704124 0.557377049180328 28.2 28 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 5.90295106773087e-10 1.06327840118747e-08 1.82778866846563 0.556962025316456 28.2 28 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 5.90295106773087e-10 1.06327840118747e-08 1.82778866846563 0.556962025316456 28.2 28 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 5.90295106773087e-10 1.06327840118747e-08 1.82778866846563 0.556962025316456 28.2 28 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 3.38523453500596e-07 2.72157556119406e-06 1.82317304051496 0.555555555555556 28.2 28 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000305624163248554 0.00125694561937195 1.82317304051496 0.555555555555556 28.2 28 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000305624163248554 0.00125694561937195 1.82317304051496 0.555555555555556 28.2 28 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000305624163248554 0.00125694561937195 1.82317304051496 0.555555555555556 28.2 28 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 3.20485473223898e-06 2.04507097936147e-05 1.82317304051496 0.555555555555556 28.2 28 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.08687778418925e-05 0.000159731894069138 1.82317304051496 0.555555555555556 28.2 28 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00318056687421868 0.00992532162722188 1.82317304051496 0.555555555555556 28.2 28 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00318056687421868 0.00992532162722188 1.82317304051496 0.555555555555556 28.2 28 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00318056687421868 0.00992532162722188 1.82317304051496 0.555555555555556 28.2 28 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00318056687421868 0.00992532162722188 1.82317304051496 0.555555555555556 28.2 28 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00318056687421868 0.00992532162722188 1.82317304051496 0.555555555555556 28.2 28 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0371968548942256 0.0804424384718586 1.82317304051496 0.555555555555556 28.2 28 2 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0371968548942256 0.0804424384718586 1.82317304051496 0.555555555555556 28.2 28 2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.0371968548942256 0.0804424384718586 1.82317304051496 0.555555555555556 28.2 28 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0371968548942256 0.0804424384718586 1.82317304051496 0.555555555555556 28.2 28 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0371968548942256 0.0804424384718586 1.82317304051496 0.555555555555556 28.2 28 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0371968548942256 0.0804424384718586 1.82317304051496 0.555555555555556 28.2 28 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0371968548942256 0.0804424384718586 1.82317304051496 0.555555555555556 28.2 28 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0371968548942256 0.0804424384718586 1.82317304051496 0.555555555555556 28.2 28 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.02331372051389e-10 5.81375057336657e-09 1.81877985246552 0.55421686746988 28.2 28 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.7861108708094e-09 3.88689781290371e-08 1.81824554581086 0.554054054054054 28.2 28 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.7861108708094e-09 3.88689781290371e-08 1.81824554581086 0.554054054054054 28.2 28 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.99061139098828e-09 2.95066667643367e-08 1.8135773929333 0.552631578947368 28.2 28 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 2.18361105046101e-05 0.00011508438980763 1.8135773929333 0.552631578947368 28.2 28 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000214687528550462 0.000928572501906711 1.81059943333899 0.551724137931034 28.2 28 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.54443640326567e-05 8.32474621911762e-05 1.80494131010981 0.55 28.2 28 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00220420667971695 0.00734563490687874 1.80494131010981 0.55 28.2 28 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00220420667971695 0.00734563490687874 1.80494131010981 0.55 28.2 28 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00220420667971695 0.00734563490687874 1.80494131010981 0.55 28.2 28 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00220420667971695 0.00734563490687874 1.80494131010981 0.55 28.2 28 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.18961569742983e-15 1.49045578436066e-13 1.80124013175688 0.548872180451128 28.2 28 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.41047459637259e-12 1.18417082087513e-10 1.79863032650802 0.548076923076923 28.2 28 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 7.98465872152434e-23 1.03292448733901e-20 1.79712771136474 0.547619047619048 28.2 28 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.76766948215412e-13 5.71680380251208e-12 1.79253147680882 0.546218487394958 28.2 28 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00153019541320776 0.00532388281905779 1.79002443977832 0.545454545454545 28.2 28 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0248564116859146 0.0574199250471695 1.79002443977832 0.545454545454545 28.2 28 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0248564116859146 0.0574199250471695 1.79002443977832 0.545454545454545 28.2 28 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0248564116859146 0.0574199250471695 1.79002443977832 0.545454545454545 28.2 28 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.0248564116859146 0.0574199250471695 1.79002443977832 0.545454545454545 28.2 28 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0248564116859146 0.0574199250471695 1.79002443977832 0.545454545454545 28.2 28 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.41484274384072e-09 3.47103153988419e-08 1.78624801690959 0.544303797468354 28.2 28 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 8.19499209537096e-13 2.42947369827352e-11 1.78479045018833 0.543859649122807 28.2 28 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.71976100535017e-09 2.60342543682266e-08 1.78265808405907 0.54320987654321 28.2 28 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.71976100535017e-09 2.60342543682266e-08 1.78265808405907 0.54320987654321 28.2 28 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 7.45620142954447e-05 0.000353672487808059 1.78150051387461 0.542857142857143 28.2 28 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00106396052610149 0.00379452588632187 1.77759371450208 0.541666666666667 28.2 28 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00106396052610149 0.00379452588632187 1.77759371450208 0.541666666666667 28.2 28 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00106396052610149 0.00379452588632187 1.77759371450208 0.541666666666667 28.2 28 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.84044763267617e-11 1.07624327832784e-09 1.7748031435217 0.540816326530612 28.2 28 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 5.24496398396147e-05 0.000260055182898159 1.77389809347401 0.540540540540541 28.2 28 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 5.24496398396147e-05 0.000260055182898159 1.77389809347401 0.540540540540541 28.2 28 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.44852173785671e-11 8.76294005887517e-10 1.77212419538054 0.54 28.2 28 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000740845087097595 0.00274537124723927 1.76707540849911 0.538461538461538 28.2 28 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0167579114269548 0.0407632614710371 1.76707540849911 0.538461538461538 28.2 28 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0167579114269548 0.0407632614710371 1.76707540849911 0.538461538461538 28.2 28 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 7.37711132637443e-08 7.44512724640483e-07 1.76330765709506 0.537313432835821 28.2 28 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 7.37711132637443e-08 7.44512724640483e-07 1.76330765709506 0.537313432835821 28.2 28 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.36734323812055e-06 1.00295331332245e-05 1.76240060583112 0.537037037037037 28.2 28 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 2.59826996639108e-05 0.000134939348984471 1.76091835132664 0.536585365853659 28.2 28 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 9.67335678754902e-07 7.32190782376716e-06 1.75805971763942 0.535714285714286 28.2 28 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000516530918648956 0.00200826092141384 1.75805971763942 0.535714285714286 28.2 28 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000516530918648956 0.00200826092141384 1.75805971763942 0.535714285714286 28.2 28 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 6.84414173945161e-07 5.29305092132589e-06 1.75401820104715 0.53448275862069 28.2 28 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.63348274220239e-08 2.90499685438294e-07 1.75324311567329 0.534246575342466 28.2 28 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 4.84288891135019e-07 3.78650050596226e-06 1.75024611889436 0.533333333333333 28.2 28 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0113744452547609 0.0289032778527229 1.75024611889436 0.533333333333333 28.2 28 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0113744452547609 0.0289032778527229 1.75024611889436 0.533333333333333 28.2 28 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0113744452547609 0.0289032778527229 1.75024611889436 0.533333333333333 28.2 28 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.00025196294769612 0.0010571031431979 1.74340921999243 0.53125 28.2 28 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 9.68615665561641e-18 5.10496330405265e-16 1.7428298217804 0.531073446327684 28.2 28 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.40363865864399e-06 3.70421862245951e-05 1.74131629175714 0.530612244897959 28.2 28 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 4.51562450826238e-06 2.73435475542867e-05 1.73737666213778 0.529411764705882 28.2 28 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000176246957688647 0.000776468795018406 1.73737666213778 0.529411764705882 28.2 28 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000176246957688647 0.000776468795018406 1.73737666213778 0.529411764705882 28.2 28 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00776155308769234 0.0217415158342248 1.73737666213778 0.529411764705882 28.2 28 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00776155308769234 0.0217415158342248 1.73737666213778 0.529411764705882 28.2 28 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.35617649821115e-09 4.50550863863629e-08 1.73737666213778 0.529411764705882 28.2 28 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.35617649821115e-09 4.50550863863629e-08 1.73737666213778 0.529411764705882 28.2 28 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.35617649821115e-09 4.50550863863629e-08 1.73737666213778 0.529411764705882 28.2 28 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 8.60407377743223e-08 8.50249790644865e-07 1.73461892140423 0.528571428571429 28.2 28 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.18521685488068e-06 2.041989202346e-05 1.73373436305573 0.528301886792453 28.2 28 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000123395631508238 0.000550445089768725 1.73201438848921 0.527777777777778 28.2 28 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.39466886398762e-11 6.19566144264433e-10 1.73035695845238 0.527272727272727 28.2 28 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 2.24742097770555e-06 1.51567774941943e-05 1.73035695845238 0.527272727272727 28.2 28 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.24742097770555e-06 1.51567774941943e-05 1.73035695845238 0.527272727272727 28.2 28 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.24742097770555e-06 1.51567774941943e-05 1.73035695845238 0.527272727272727 28.2 28 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.24742097770555e-06 1.51567774941943e-05 1.73035695845238 0.527272727272727 28.2 28 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 2.24742097770555e-06 1.51567774941943e-05 1.73035695845238 0.527272727272727 28.2 28 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 8.50198976916448e-10 1.45763029415916e-08 1.72907378681096 0.526881720430108 28.2 28 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00531906300430956 0.0153529952436765 1.72721656469838 0.526315789473684 28.2 28 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00531906300430956 0.0153529952436765 1.72721656469838 0.526315789473684 28.2 28 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00531906300430956 0.0153529952436765 1.72721656469838 0.526315789473684 28.2 28 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00365818603887819 0.0113165189854862 1.7189917239141 0.523809523809524 28.2 28 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.7352659367437e-09 3.88689781290371e-08 1.71378265808406 0.522222222222222 28.2 28 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.97024758551086e-07 1.62061405444043e-06 1.71219729022274 0.521739130434783 28.2 28 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00252345019642435 0.00825313507162483 1.71219729022274 0.521739130434783 28.2 28 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00252345019642435 0.00825313507162483 1.71219729022274 0.521739130434783 28.2 28 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 5.14292690369928e-06 3.06208576734899e-05 1.70162817114729 0.518518518518518 28.2 28 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.2340799854162e-08 1.43942280266168e-07 1.69876829186805 0.517647058823529 28.2 28 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 9.70159095552094e-05 0.000446775531705706 1.68087660808452 0.51219512195122 28.2 28 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 9.70159095552094e-05 0.000446775531705706 1.68087660808452 0.51219512195122 28.2 28 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 9.70159095552094e-05 0.000446775531705706 1.68087660808452 0.51219512195122 28.2 28 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 9.70159095552094e-05 0.000446775531705706 1.68087660808452 0.51219512195122 28.2 28 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 8.70619509613086e-10 1.46375496944365e-08 1.67241065447237 0.509615384615385 28.2 28 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.15830888234135e-05 6.38865713012301e-05 1.67181527866088 0.509433962264151 28.2 28 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 8.14567378991499e-06 4.58153905258855e-05 1.67068947712643 0.509090909090909 28.2 28 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 8.14567378991499e-06 4.58153905258855e-05 1.67068947712643 0.509090909090909 28.2 28 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 2.84103097542869e-06 1.84602149681964e-05 1.66775501083171 0.508196721311475 28.2 28 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 2.00152081368194e-06 1.3826039407133e-05 1.66690106561367 0.507936507936508 28.2 28 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00190255816845187 0.00650802950410338 1.64085573646346 0.5 28.2 28 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.026856005126429 0.0612888240500094 1.64085573646346 0.5 28.2 28 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.026856005126429 0.0612888240500094 1.64085573646346 0.5 28.2 28 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.026856005126429 0.0612888240500094 1.64085573646346 0.5 28.2 28 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.026856005126429 0.0612888240500094 1.64085573646346 0.5 28.2 28 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.32788290274075e-10 2.73851792840591e-09 1.64085573646346 0.5 28.2 28 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.34510181831208e-07 1.25103260618176e-06 1.64085573646346 0.5 28.2 28 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.82124131699654e-07 3.02090355227004e-06 1.64085573646346 0.5 28.2 28 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 8.91009403520973e-06 4.97218188709939e-05 1.64085573646346 0.5 28.2 28 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 7.4281530198061e-05 0.000353520459772043 1.64085573646346 0.5 28.2 28 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000106031440279944 0.00048359852409731 1.64085573646346 0.5 28.2 28 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000106031440279944 0.00048359852409731 1.64085573646346 0.5 28.2 28 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00274943853524392 0.00887177105590045 1.64085573646346 0.5 28.2 28 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00274943853524392 0.00887177105590045 1.64085573646346 0.5 28.2 28 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00274943853524392 0.00887177105590045 1.64085573646346 0.5 28.2 28 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00274943853524392 0.00887177105590045 1.64085573646346 0.5 28.2 28 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0039829398667472 0.0122149211861665 1.64085573646346 0.5 28.2 28 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0039829398667472 0.0122149211861665 1.64085573646346 0.5 28.2 28 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0039829398667472 0.0122149211861665 1.64085573646346 0.5 28.2 28 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00578617666454862 0.0165668599469873 1.64085573646346 0.5 28.2 28 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00578617666454862 0.0165668599469873 1.64085573646346 0.5 28.2 28 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00843391932890214 0.0234403656348198 1.64085573646346 0.5 28.2 28 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.040048155284866 0.0854400674218355 1.64085573646346 0.5 28.2 28 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.040048155284866 0.0854400674218355 1.64085573646346 0.5 28.2 28 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.040048155284866 0.0854400674218355 1.64085573646346 0.5 28.2 28 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.040048155284866 0.0854400674218355 1.64085573646346 0.5 28.2 28 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.040048155284866 0.0854400674218355 1.64085573646346 0.5 28.2 28 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0603473024529522 0.116994838406745 1.64085573646346 0.5 28.2 28 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.10828574198485e-06 2.01049573220202e-05 1.64085573646346 0.5 28.2 28 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 6.269524766614e-06 3.64144234403744e-05 1.64085573646346 0.5 28.2 28 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000916542692828899 0.00333565281814712 1.64085573646346 0.5 28.2 28 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00131930597351803 0.00464696138692118 1.64085573646346 0.5 28.2 28 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00131930597351803 0.00464696138692118 1.64085573646346 0.5 28.2 28 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.018150966308028 0.0438104216520995 1.64085573646346 0.5 28.2 28 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.018150966308028 0.0438104216520995 1.64085573646346 0.5 28.2 28 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.02803881947597e-07 1.00198578090021e-06 1.62199532569951 0.494252873563218 28.2 28 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.02803881947597e-07 1.00198578090021e-06 1.62199532569951 0.494252873563218 28.2 28 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 6.3141387789055e-13 1.91170627284735e-11 1.62034503975767 0.49375 28.2 28 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.17453904974146e-06 8.79667930411627e-06 1.6183782606215 0.493150684931507 28.2 28 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.35017993715099e-06 2.12505491381119e-05 1.61636535233714 0.492537313432836 28.2 28 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 7.10563401494297e-20 5.6173984462577e-18 1.61561180205633 0.492307692307692 28.2 28 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.3623370329364e-05 7.37112394626803e-05 1.61304462228611 0.491525423728814 28.2 28 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.46261805128729e-09 4.60495839904843e-08 1.61102199580049 0.490909090909091 28.2 28 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.000677623983290697 0.00259209389307167 1.59650828412661 0.486486486486487 28.2 28 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 6.9900038540567e-14 2.36827987721969e-12 1.59602361251637 0.486338797814208 28.2 28 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 7.36196886364312e-09 9.43791143510285e-08 1.59569456940483 0.486238532110092 28.2 28 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.51430528073533e-06 1.67189552078803e-05 1.59527641045059 0.486111111111111 28.2 28 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.51430528073533e-06 1.67189552078803e-05 1.59527641045059 0.486111111111111 28.2 28 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.21267377480257e-15 4.93038509012589e-14 1.59397414399308 0.485714285714286 28.2 28 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 5.05364516401263e-06 3.02157019680251e-05 1.5925952736263 0.485294117647059 28.2 28 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00139610350335577 0.00488121691713824 1.59113283535851 0.484848484848485 28.2 28 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.01712916976835e-05 5.63180859369792e-05 1.58957899469898 0.484375 28.2 28 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00200841830469507 0.00683727092722748 1.58792490625496 0.483870967741935 28.2 28 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 6.84461549637983e-16 2.86467289745544e-14 1.58118825513752 0.481818181818182 28.2 28 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00417934009895933 0.0127076943607246 1.58008330177963 0.481481481481481 28.2 28 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00417934009895933 0.0127076943607246 1.58008330177963 0.481481481481481 28.2 28 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00417934009895933 0.0127076943607246 1.58008330177963 0.481481481481481 28.2 28 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00417934009895933 0.0127076943607246 1.58008330177963 0.481481481481481 28.2 28 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.60424650196508e-59 1.14142138614815e-56 1.57774590044564 0.480769230769231 28.2 28 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.38058447313832e-10 1.29661379077479e-08 1.57725667691061 0.48062015503876 28.2 28 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 6.15857195004369e-08 6.49159102586087e-07 1.57522150700492 0.48 28.2 28 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.0001192598480497 0.000537046720806086 1.57522150700492 0.48 28.2 28 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0001192598480497 0.000537046720806086 1.57522150700492 0.48 28.2 28 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00604859961035623 0.0171457315648146 1.57522150700492 0.48 28.2 28 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00604859961035623 0.0171457315648146 1.57522150700492 0.48 28.2 28 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00604859961035623 0.0171457315648146 1.57522150700492 0.48 28.2 28 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.06832435898443e-09 3.0342531575617e-08 1.57415428376169 0.479674796747967 28.2 28 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 7.52144022863845e-06 4.3157296150615e-05 1.56951418270418 0.478260869565217 28.2 28 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00877700926032921 0.0242677963776547 1.56951418270418 0.478260869565217 28.2 28 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 6.90975137233176e-07 5.31490605558275e-06 1.56453686500004 0.476744186046512 28.2 28 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000493312409105214 0.00193383900318655 1.56271974901282 0.476190476190476 28.2 28 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0127754950471057 0.0315616830764435 1.56271974901282 0.476190476190476 28.2 28 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.38287310756602e-13 1.06973965157032e-11 1.56188407000265 0.475935828877005 28.2 28 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000704960573133489 0.00266089892723861 1.55881294964029 0.475 28.2 28 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.75931976342244e-06 1.80115230428905e-05 1.55670928843969 0.474358974358974 28.2 28 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.00089538985806e-18 1.35584482846096e-16 1.55200073268385 0.472924187725632 28.2 28 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 8.69609670123267e-05 0.000409753165756758 1.55135451447454 0.472727272727273 28.2 28 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 7.8094258210152e-06 4.44512517732185e-05 1.54969708443771 0.472222222222222 28.2 28 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 5.87375827127477e-34 1.19405114571771e-31 1.54867282992057 0.471910112359551 28.2 28 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.94934332612538e-11 1.7402947004733e-09 1.54558024208816 0.470967741935484 28.2 28 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0273860002816597 0.0621535540682644 1.54433481078914 0.470588235294118 28.2 28 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0273860002816597 0.0621535540682644 1.54433481078914 0.470588235294118 28.2 28 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.87195061816132e-07 1.62061405444043e-06 1.54240439227565 0.47 28.2 28 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.21458335908425e-09 1.87864360867054e-08 1.53461327870683 0.467625899280576 28.2 28 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0404023700141386 0.0856819262743952 1.53146535403256 0.466666666666667 28.2 28 2 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.0404023700141386 0.0856819262743952 1.53146535403256 0.466666666666667 28.2 28 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 2.1335778466732e-20 1.78593016224468e-18 1.5301231407512 0.466257668711656 28.2 28 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 4.12092840997677e-06 2.54960049017258e-05 1.52079312160028 0.463414634146341 28.2 28 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00102832675255553 0.00369522466890537 1.52079312160028 0.463414634146341 28.2 28 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.39000961766936e-10 4.72358845269931e-09 1.51623378179535 0.462025316455696 28.2 28 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 4.52852312847193e-05 0.000229326989744326 1.51463606442781 0.461538461538462 28.2 28 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00146730298843331 0.00511757880524657 1.51463606442781 0.461538461538462 28.2 28 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000254390360452844 0.00106145643760111 1.51463606442781 0.461538461538462 28.2 28 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00887645196045249 0.0243375551825123 1.51463606442781 0.461538461538462 28.2 28 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00887645196045249 0.0243375551825123 1.51463606442781 0.461538461538462 28.2 28 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0600112214487899 0.116994838406745 1.51463606442781 0.461538461538462 28.2 28 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0600112214487899 0.116994838406745 1.51463606442781 0.461538461538462 28.2 28 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0600112214487899 0.116994838406745 1.51463606442781 0.461538461538462 28.2 28 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0600112214487899 0.116994838406745 1.51463606442781 0.461538461538462 28.2 28 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0003610187797649 0.00145945944206095 1.50958727754638 0.46 28.2 28 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 4.18755826108979e-06 2.56848939893568e-05 1.50572644051941 0.458823529411765 28.2 28 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 4.18755826108979e-06 2.56848939893568e-05 1.50572644051941 0.458823529411765 28.2 28 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.012833529516437 0.0316501083221662 1.50411775842484 0.458333333333333 28.2 28 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000128054518504498 0.000569442436974688 1.50180016557673 0.457627118644068 28.2 28 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 8.30124446471394e-06 4.65065782412911e-05 1.49905338886785 0.45679012345679 28.2 28 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.000727941225453957 0.00270459625018533 1.4981726289449 0.456521739130435 28.2 28 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0899230447588168 0.164051913707431 1.4916870331486 0.454545454545455 28.2 28 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 5.94272208844131e-06 3.48003849047407e-05 1.48821799353663 0.453488372093023 28.2 28 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00209103769186043 0.00703438920926097 1.47677016281711 0.45 28.2 28 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00209103769186043 0.00703438920926097 1.47677016281711 0.45 28.2 28 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.000255853519393661 0.00106145643760111 1.47111203958793 0.448275862068966 28.2 28 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.000255853519393661 0.00106145643760111 1.47111203958793 0.448275862068966 28.2 28 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00879984745668995 0.0242677963776547 1.47111203958793 0.448275862068966 28.2 28 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00879984745668995 0.0242677963776547 1.47111203958793 0.448275862068966 28.2 28 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.25595133481954e-05 0.000167870244545225 1.46813407999362 0.447368421052632 28.2 28 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.45830222724762e-07 1.33881552862797e-06 1.46743195943887 0.447154471544715 28.2 28 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.012634141449647 0.031518011232437 1.45853843241197 0.444444444444444 28.2 28 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0394207690660546 0.0848649839349406 1.45853843241197 0.444444444444444 28.2 28 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000718628508257249 0.00270459625018533 1.45152622840998 0.442307692307692 28.2 28 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.68556286643709e-12 4.895012161102e-11 1.45071365541405 0.44206008583691 28.2 28 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0020633104435643 0.00697408731874584 1.45005855780492 0.441860465116279 28.2 28 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0020633104435643 0.00697408731874584 1.45005855780492 0.441860465116279 28.2 28 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00603345564191926 0.0171457315648146 1.44781388511482 0.441176470588235 28.2 28 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.37223999426416e-08 1.58755895271374e-07 1.44654387293489 0.440789473684211 28.2 28 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.51241590405684e-06 1.07073026441437e-05 1.44515734587608 0.440366972477064 28.2 28 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0181645458712148 0.0438104216520995 1.44395304808785 0.44 28.2 28 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0181645458712148 0.0438104216520995 1.44395304808785 0.44 28.2 28 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.49172061302674e-06 1.06135921616852e-05 1.43574876940553 0.4375 28.2 28 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00859884435578026 0.0238521550063846 1.43574876940553 0.4375 28.2 28 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0577090173411134 0.114532680162349 1.43574876940553 0.4375 28.2 28 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0577090173411134 0.114532680162349 1.43574876940553 0.4375 28.2 28 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0577090173411134 0.114532680162349 1.43574876940553 0.4375 28.2 28 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0577090173411134 0.114532680162349 1.43574876940553 0.4375 28.2 28 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00201749196415387 0.00685176865152974 1.42683107518562 0.434782608695652 28.2 28 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 5.38201323858489e-46 1.91465120962657e-43 1.425688467718 0.434434434434434 28.2 28 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 8.74344149000069e-10 1.46375496944365e-08 1.4186565221507 0.432291666666667 28.2 28 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.88066925633637e-07 1.62061405444043e-06 1.41656610342169 0.431654676258993 28.2 28 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00139360500349118 0.00488121691713824 1.41564024322338 0.431372549019608 28.2 28 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000341208802466533 0.00139123245246383 1.41366032679929 0.430769230769231 28.2 28 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.40348917992211e-06 1.00797937528992e-05 1.41032228588595 0.429752066115702 28.2 28 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.40348917992211e-06 1.00797937528992e-05 1.41032228588595 0.429752066115702 28.2 28 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.54511609965023e-07 2.06954297702987e-06 1.40644777411154 0.428571428571429 28.2 28 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000237397647365854 0.00101142770120242 1.40644777411154 0.428571428571429 28.2 28 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00831231207750247 0.0231475931238474 1.40644777411154 0.428571428571429 28.2 28 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00831231207750247 0.0231475931238474 1.40644777411154 0.428571428571429 28.2 28 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0174953342078329 0.0424844037162904 1.40644777411154 0.428571428571429 28.2 28 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0377269377566326 0.081341564284376 1.40644777411154 0.428571428571429 28.2 28 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0377269377566326 0.081341564284376 1.40644777411154 0.428571428571429 28.2 28 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0848776336905606 0.158922200975879 1.40644777411154 0.428571428571429 28.2 28 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0848776336905606 0.158922200975879 1.40644777411154 0.428571428571429 28.2 28 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0848776336905606 0.158922200975879 1.40644777411154 0.428571428571429 28.2 28 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0848776336905606 0.158922200975879 1.40644777411154 0.428571428571429 28.2 28 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0848776336905606 0.158922200975879 1.40644777411154 0.428571428571429 28.2 28 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0848776336905606 0.158922200975879 1.40644777411154 0.428571428571429 28.2 28 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0848776336905606 0.158922200975879 1.40644777411154 0.428571428571429 28.2 28 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00195802508856185 0.00668170192091969 1.40644777411154 0.428571428571429 28.2 28 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 5.97750019500182e-09 7.73271161589781e-08 1.39876226714918 0.426229508196721 28.2 28 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.011777503346464 0.0298741305918329 1.39224123093869 0.424242424242424 28.2 28 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00188858776666272 0.00647580817340011 1.38841639239216 0.423076923076923 28.2 28 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00188858776666272 0.00647580817340011 1.38841639239216 0.423076923076923 28.2 28 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0249758147391072 0.0575090362034782 1.38841639239216 0.423076923076923 28.2 28 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0249758147391072 0.0575090362034782 1.38841639239216 0.423076923076923 28.2 28 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.1497074856384e-07 1.10542821085368e-06 1.38285955148493 0.421383647798742 28.2 28 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0545168425916676 0.110087743558127 1.3817732517587 0.421052631578947 28.2 28 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0545168425916676 0.110087743558127 1.3817732517587 0.421052631578947 28.2 28 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0545168425916676 0.110087743558127 1.3817732517587 0.421052631578947 28.2 28 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.06894559425983e-08 8.02944725918304e-07 1.38072007092657 0.420731707317073 28.2 28 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0166854874489092 0.040726326997938 1.37620158542097 0.419354838709677 28.2 28 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0166854874489092 0.040726326997938 1.37620158542097 0.419354838709677 28.2 28 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.82434341563383e-18 1.29802034022347e-16 1.37596422743797 0.419282511210762 28.2 28 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.06599473727393e-15 7.95438547432044e-14 1.36884221865401 0.417112299465241 28.2 28 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.89026705469009e-07 2.33684660160454e-06 1.36737978038622 0.416666666666667 28.2 28 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0356720805624331 0.0786778104922121 1.36737978038622 0.416666666666667 28.2 28 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.125547965811639 0.221656024007397 1.36737978038622 0.416666666666667 28.2 28 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.125547965811639 0.221656024007397 1.36737978038622 0.416666666666667 28.2 28 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.125547965811639 0.221656024007397 1.36737978038622 0.416666666666667 28.2 28 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.125547965811639 0.221656024007397 1.36737978038622 0.416666666666667 28.2 28 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.125547965811639 0.221656024007397 1.36737978038622 0.416666666666667 28.2 28 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.125547965811639 0.221656024007397 1.36737978038622 0.416666666666667 28.2 28 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.011224120680731 0.0287264815264033 1.36737978038622 0.416666666666667 28.2 28 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.011224120680731 0.0287264815264033 1.36737978038622 0.416666666666667 28.2 28 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.91443059882489e-11 5.04487915208854e-10 1.36335807514979 0.415441176470588 28.2 28 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00759126723889919 0.0213485637963509 1.36070963511604 0.414634146341463 28.2 28 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.53065776435447e-06 1.07828019736456e-05 1.35956618164115 0.414285714285714 28.2 28 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000591630285668879 0.00227537809866707 1.35956618164115 0.414285714285714 28.2 28 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 4.38464838805235e-09 5.72417858366834e-08 1.35956618164115 0.414285714285714 28.2 28 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.81325177662989e-07 3.02090355227004e-06 1.35867035503344 0.414012738853503 28.2 28 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0236333248556986 0.0551315102781296 1.35794957500424 0.413793103448276 28.2 28 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0157983367396453 0.0386936887788559 1.3512929594405 0.411764705882353 28.2 28 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0157983367396453 0.0386936887788559 1.3512929594405 0.411764705882353 28.2 28 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0157983367396453 0.0386936887788559 1.3512929594405 0.411764705882353 28.2 28 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0789351292827309 0.149169573664444 1.3512929594405 0.411764705882353 28.2 28 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0789351292827309 0.149169573664444 1.3512929594405 0.411764705882353 28.2 28 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0789351292827309 0.149169573664444 1.3512929594405 0.411764705882353 28.2 28 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0789351292827309 0.149169573664444 1.3512929594405 0.411764705882353 28.2 28 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0789351292827309 0.149169573664444 1.3512929594405 0.411764705882353 28.2 28 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0789351292827309 0.149169573664444 1.3512929594405 0.411764705882353 28.2 28 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 0.000195625928089479 0.000848706389241854 1.3512929594405 0.411764705882353 28.2 28 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 8.12239141481114e-06 4.58153905258855e-05 1.34973617031672 0.411290322580645 28.2 28 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 2.19641092340328e-08 2.44179120625225e-07 1.34933314369076 0.411167512690355 28.2 28 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.00240373638970314 0.00789957709595282 1.34784578352356 0.410714285714286 28.2 28 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.010632678377287 0.0273110132326342 1.34634316838028 0.41025641025641 28.2 28 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.010632678377287 0.0273110132326342 1.34634316838028 0.41025641025641 28.2 28 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.010632678377287 0.0273110132326342 1.34634316838028 0.41025641025641 28.2 28 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 5.40973012975169e-06 3.20751915609861e-05 1.34251832983374 0.409090909090909 28.2 28 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00113203741318703 0.00400718716160485 1.34251832983374 0.409090909090909 28.2 28 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0509687144117528 0.1055727519766 1.34251832983374 0.409090909090909 28.2 28 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0509687144117528 0.1055727519766 1.34251832983374 0.409090909090909 28.2 28 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0509687144117528 0.1055727519766 1.34251832983374 0.409090909090909 28.2 28 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0334607151256112 0.0740858782156724 1.3369935630443 0.407407407407407 28.2 28 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0334607151256112 0.0740858782156724 1.3369935630443 0.407407407407407 28.2 28 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000370909364235479 0.00149097182290137 1.3369935630443 0.407407407407407 28.2 28 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000370909364235479 0.00149097182290137 1.3369935630443 0.407407407407407 28.2 28 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 7.28624812036618e-08 7.44512724640483e-07 1.33319528587656 0.40625 28.2 28 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.00156328863798103 0.00542575544352928 1.33319528587656 0.40625 28.2 28 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.022218453775787 0.0519160258176434 1.33319528587656 0.40625 28.2 28 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.000509892692713601 0.00199334423552597 1.32930084979318 0.40506329113924 28.2 28 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00024343772788824 0.00102980755930361 1.32743385421763 0.404494382022472 28.2 28 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.60543903668529e-17 8.15907053286848e-16 1.32735890876516 0.404471544715447 28.2 28 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.4991328204548e-07 2.04383103649838e-06 1.3198187445467 0.402173913043478 28.2 28 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000230654867265657 0.000985651279636727 1.3198187445467 0.402173913043478 28.2 28 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.32407405724208e-26 3.30715738345549e-24 1.3194076856582 0.402048655569782 28.2 28 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.78990933403305e-05 9.57534203883091e-05 1.31785263873443 0.401574803149606 28.2 28 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00139587799947222 0.00488121691713824 1.31268458917077 0.4 28.2 28 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0728390961129844 0.139690072464659 1.31268458917077 0.4 28.2 28 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.000104722383175106 0.000480709520187664 1.31268458917077 0.4 28.2 28 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000456404063788486 0.0018040638410306 1.31268458917077 0.4 28.2 28 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000456404063788486 0.0018040638410306 1.31268458917077 0.4 28.2 28 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000456404063788486 0.0018040638410306 1.31268458917077 0.4 28.2 28 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000456404063788486 0.0018040638410306 1.31268458917077 0.4 28.2 28 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000456404063788486 0.0018040638410306 1.31268458917077 0.4 28.2 28 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0473437703565786 0.0984944228324728 1.31268458917077 0.4 28.2 28 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0473437703565786 0.0984944228324728 1.31268458917077 0.4 28.2 28 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0473437703565786 0.0984944228324728 1.31268458917077 0.4 28.2 28 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0312142478381608 0.0695115409604114 1.31268458917077 0.4 28.2 28 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.114527809474842 0.204226908374311 1.31268458917077 0.4 28.2 28 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.114527809474842 0.204226908374311 1.31268458917077 0.4 28.2 28 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.114527809474842 0.204226908374311 1.31268458917077 0.4 28.2 28 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.114527809474842 0.204226908374311 1.31268458917077 0.4 28.2 28 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 7.77700400739796e-06 4.44444847491056e-05 1.30809478291493 0.398601398601399 28.2 28 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000430598597344812 0.00172603325076526 1.30522615400503 0.397727272727273 28.2 28 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 2.49157517797566e-06 1.67189552078803e-05 1.30453126874114 0.397515527950311 28.2 28 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.00279200961633568 0.00898875494127982 1.30226645751068 0.396825396825397 28.2 28 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.50324688706125e-05 0.000228861440010291 1.30183595620242 0.396694214876033 28.2 28 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 3.37499937119696e-06 2.12505491381119e-05 1.3003007722918 0.39622641509434 28.2 28 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 3.37499937119696e-06 2.12505491381119e-05 1.3003007722918 0.39622641509434 28.2 28 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00881911861859972 0.0242738990217938 1.29901079136691 0.395833333333333 28.2 28 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 3.18567535432756e-06 2.041989202346e-05 1.29647860658841 0.395061728395062 28.2 28 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0193820485639556 0.0466677751379168 1.29541242352378 0.394736842105263 28.2 28 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0290050715548468 0.0653073050989668 1.29279542872879 0.393939393939394 28.2 28 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0290050715548468 0.0653073050989668 1.29279542872879 0.393939393939394 28.2 28 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0290050715548468 0.0653073050989668 1.29279542872879 0.393939393939394 28.2 28 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0290050715548468 0.0653073050989668 1.29279542872879 0.393939393939394 28.2 28 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 4.30642560146482e-06 2.63006164415641e-05 1.29217389246498 0.39375 28.2 28 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 6.17477792546933e-06 3.60111024096019e-05 1.29151225708737 0.393548387096774 28.2 28 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.10513265865253e-08 1.34410578911329e-07 1.28924379293558 0.392857142857143 28.2 28 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.10513265865253e-08 1.34410578911329e-07 1.28924379293558 0.392857142857143 28.2 28 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.10513265865253e-08 1.34410578911329e-07 1.28924379293558 0.392857142857143 28.2 28 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0437912557194675 0.0915050761950107 1.28924379293558 0.392857142857143 28.2 28 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0437912557194675 0.0915050761950107 1.28924379293558 0.392857142857143 28.2 28 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0121558091995491 0.0305074364919902 1.28414796766706 0.391304347826087 28.2 28 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0669197337736357 0.128511175654364 1.28414796766706 0.391304347826087 28.2 28 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0669197337736357 0.128511175654364 1.28414796766706 0.391304347826087 28.2 28 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.19156174394492e-07 1.12290884876398e-06 1.28030896028988 0.390134529147982 28.2 28 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.31643534228851e-05 0.000121634224799873 1.28010021993603 0.390070921985816 28.2 28 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.777879464711e-05 0.000239398678812808 1.2776128635059 0.389312977099237 28.2 28 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.777879464711e-05 0.000239398678812808 1.2776128635059 0.389312977099237 28.2 28 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0022943079383455 0.00755874947922824 1.27622112836047 0.388888888888889 28.2 28 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0268757738631102 0.0612888240500094 1.27622112836047 0.388888888888889 28.2 28 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.104080631238798 0.187003457389911 1.27622112836047 0.388888888888889 28.2 28 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.104080631238798 0.187003457389911 1.27622112836047 0.388888888888889 28.2 28 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.104080631238798 0.187003457389911 1.27622112836047 0.388888888888889 28.2 28 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.104080631238798 0.187003457389911 1.27622112836047 0.388888888888889 28.2 28 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0113084356870598 0.0288903123567075 1.2725003670533 0.387755102040816 28.2 28 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0403903070313723 0.0856819262743952 1.27033992500397 0.387096774193548 28.2 28 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0403903070313723 0.0856819262743952 1.27033992500397 0.387096774193548 28.2 28 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0613237426174981 0.118243476618834 1.26219672035651 0.384615384615385 28.2 28 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0613237426174981 0.118243476618834 1.26219672035651 0.384615384615385 28.2 28 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0613237426174981 0.118243476618834 1.26219672035651 0.384615384615385 28.2 28 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0613237426174981 0.118243476618834 1.26219672035651 0.384615384615385 28.2 28 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.166508431038419 0.277774322822591 1.26219672035651 0.384615384615385 28.2 28 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.166508431038419 0.277774322822591 1.26219672035651 0.384615384615385 28.2 28 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.166508431038419 0.277774322822591 1.26219672035651 0.384615384615385 28.2 28 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.166508431038419 0.277774322822591 1.26219672035651 0.384615384615385 28.2 28 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.166508431038419 0.277774322822591 1.26219672035651 0.384615384615385 28.2 28 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.166508431038419 0.277774322822591 1.26219672035651 0.384615384615385 28.2 28 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.166508431038419 0.277774322822591 1.26219672035651 0.384615384615385 28.2 28 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.9598452256434e-18 2.73350808838027e-16 1.26062633563445 0.384136858475894 28.2 28 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0371806692975906 0.0804424384718586 1.25477203376618 0.382352941176471 28.2 28 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0561099912473264 0.112617808760901 1.24478711042056 0.379310344827586 28.2 28 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0211533909486732 0.0496720714850857 1.23975766755017 0.377777777777778 28.2 28 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 6.0895689434564e-38 1.44424276775641e-35 1.23302522740056 0.375726275016139 28.2 28 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0194868105871199 0.0467617731289572 1.2306418023476 0.375 28.2 28 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0194868105871199 0.0467617731289572 1.2306418023476 0.375 28.2 28 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.148619084755079 0.251468439484516 1.2306418023476 0.375 28.2 28 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.148619084755079 0.251468439484516 1.2306418023476 0.375 28.2 28 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.148619084755079 0.251468439484516 1.2306418023476 0.375 28.2 28 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 3.76216649368011e-05 0.000192574205773626 1.22812515244504 0.374233128834356 28.2 28 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 5.77287297335546e-05 0.000285236050037667 1.22799526083717 0.374193548387097 28.2 28 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0288091283366063 0.0652792828391572 1.22110194341467 0.372093023255814 28.2 28 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.0777137587891965 0.148239515760089 1.21544869367664 0.37037037037037 28.2 28 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00388189193956194 0.0119824994143094 1.21544869367664 0.37037037037037 28.2 28 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0264278354222976 0.0607541353892238 1.21280641390778 0.369565217391304 28.2 28 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0056139483379923 0.0161386838080061 1.20905159528887 0.368421052631579 28.2 28 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.024235544400058 0.0564438292656016 1.20552666352418 0.36734693877551 28.2 28 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00305883222889515 0.00965126000380886 1.20329420673987 0.366666666666667 28.2 28 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.000252575592893384 0.0010571031431979 1.20175349712817 0.366197183098592 28.2 28 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00282353798217385 0.00906973938743428 1.19976548472597 0.365591397849462 28.2 28 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.000359710003717082 0.00145831149655102 1.19770491712661 0.364963503649635 28.2 28 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.000332744849808238 0.00136062046344001 1.19548060799481 0.364285714285714 28.2 28 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0203700685806352 0.0481046196945993 1.19334962651888 0.363636363636364 28.2 28 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0357174037793177 0.0786778104922121 1.19334962651888 0.363636363636364 28.2 28 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0640296175160818 0.123293837246799 1.19334962651888 0.363636363636364 28.2 28 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.85478703429838e-12 5.27872389961319e-11 1.18969225025547 0.362521891418564 28.2 28 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00583553980074924 0.0166746448523417 1.18616077334708 0.36144578313253 28.2 28 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00994950404106787 0.0256953616160428 1.18506247633472 0.361111111111111 28.2 28 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.107225888081233 0.192411650365189 1.18141613025369 0.36 28.2 28 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0272406650569216 0.0620215462015991 1.1764626035021 0.358490566037736 28.2 28 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.000693712797498356 0.00262730105252192 1.17375081878408 0.357664233576642 28.2 28 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0965595938279348 0.174370941646131 1.17203981175962 0.357142857142857 28.2 28 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.0965595938279348 0.174370941646131 1.17203981175962 0.357142857142857 28.2 28 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.211858874009452 0.339499074003886 1.17203981175962 0.357142857142857 28.2 28 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.211858874009452 0.339499074003886 1.17203981175962 0.357142857142857 28.2 28 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.211858874009452 0.339499074003886 1.17203981175962 0.357142857142857 28.2 28 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.211858874009452 0.339499074003886 1.17203981175962 0.357142857142857 28.2 28 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.211858874009452 0.339499074003886 1.17203981175962 0.357142857142857 28.2 28 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.211858874009452 0.339499074003886 1.17203981175962 0.357142857142857 28.2 28 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.211858874009452 0.339499074003886 1.17203981175962 0.357142857142857 28.2 28 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.211858874009452 0.339499074003886 1.17203981175962 0.357142857142857 28.2 28 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.020812337055582 0.0489519927770134 1.16447826458697 0.354838709677419 28.2 28 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.0870964715201154 0.1609588038612 1.16447826458697 0.354838709677419 28.2 28 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0398344081898384 0.0854400674218355 1.16227281332828 0.354166666666667 28.2 28 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0010868034756283 0.00386630336454768 1.15825110809185 0.352941176470588 28.2 28 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0786744983625314 0.149169573664444 1.15825110809185 0.352941176470588 28.2 28 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.186628515012724 0.30693587219563 1.15825110809185 0.352941176470588 28.2 28 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.186628515012724 0.30693587219563 1.15825110809185 0.352941176470588 28.2 28 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00784056207216263 0.0219196853215863 1.15605745069017 0.352272727272727 28.2 28 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.165383319451403 0.277774322822591 1.14859901552442 0.35 28.2 28 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.165383319451403 0.277774322822591 1.14859901552442 0.35 28.2 28 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.165383319451403 0.277774322822591 1.14859901552442 0.35 28.2 28 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0529926602862274 0.109287761720727 1.14146486014849 0.347826086956522 28.2 28 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.147222452018461 0.249997075444236 1.14146486014849 0.347826086956522 28.2 28 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.147222452018461 0.249997075444236 1.14146486014849 0.347826086956522 28.2 28 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.147222452018461 0.249997075444236 1.14146486014849 0.347826086956522 28.2 28 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.131527023914975 0.231350995093954 1.13597704832086 0.346153846153846 28.2 28 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.131527023914975 0.231350995093954 1.13597704832086 0.346153846153846 28.2 28 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.00557139625297934 0.0160487790849992 1.13479742521772 0.345794392523364 28.2 28 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00510991976784964 0.0148396241421429 1.13368214519294 0.345454545454545 28.2 28 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 9.21231855805398e-09 1.16009993877087e-07 1.13368214519294 0.345454545454545 28.2 28 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.036192559244174 0.0793559503920795 1.13162464583687 0.344827586206897 28.2 28 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.036192559244174 0.0793559503920795 1.13162464583687 0.344827586206897 28.2 28 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.036192559244174 0.0793559503920795 1.13162464583687 0.344827586206897 28.2 28 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00110506801432543 0.00392147577153389 1.12874152572009 0.343949044585987 28.2 28 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0775696218255067 0.148163183701605 1.12058440538968 0.341463414634146 28.2 28 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0575543075553317 0.114532680162349 1.11578190079515 0.34 28.2 28 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.052212880998835 0.107835892106447 1.11454351910726 0.339622641509434 28.2 28 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.052212880998835 0.107835892106447 1.11454351910726 0.339622641509434 28.2 28 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0923133805747474 0.167127150836979 1.09390382430897 0.333333333333333 28.2 28 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.158433656477864 0.26775664271734 1.09390382430897 0.333333333333333 28.2 28 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.200851690087889 0.328897531639892 1.09390382430897 0.333333333333333 28.2 28 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0753380002033398 0.144094051464183 1.09390382430897 0.333333333333333 28.2 28 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0753380002033398 0.144094051464183 1.09390382430897 0.333333333333333 28.2 28 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.126760868371368 0.223520093794866 1.09390382430897 0.333333333333333 28.2 28 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.177999515177513 0.294869976830734 1.09390382430897 0.333333333333333 28.2 28 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.177999515177513 0.294869976830734 1.09390382430897 0.333333333333333 28.2 28 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.177999515177513 0.294869976830734 1.09390382430897 0.333333333333333 28.2 28 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.227902456899687 0.359635897930213 1.09390382430897 0.333333333333333 28.2 28 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.141511629326593 0.243495826519639 1.09390382430897 0.333333333333333 28.2 28 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.260524406276757 0.394809616753807 1.09390382430897 0.333333333333333 28.2 28 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.260524406276757 0.394809616753807 1.09390382430897 0.333333333333333 28.2 28 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.260524406276757 0.394809616753807 1.09390382430897 0.333333333333333 28.2 28 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.260524406276757 0.394809616753807 1.09390382430897 0.333333333333333 28.2 28 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.260524406276757 0.394809616753807 1.09390382430897 0.333333333333333 28.2 28 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0596075042932634 0.116994838406745 1.07597097473014 0.327868852459016 28.2 28 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.167423609234439 0.278647714550418 1.05861660416997 0.32258064516129 28.2 28 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000800925527996647 0.00296030396451748 1.05529545403925 0.32156862745098 28.2 28 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.211304751458114 0.339499074003886 1.05014767133661 0.32 28.2 28 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0328522936934455 0.0730450217590203 1.048794388255 0.319587628865979 28.2 28 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.271706894876639 0.411317990861125 1.03632993881903 0.315789473684211 28.2 28 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0218789655548941 0.0512068552378526 1.03360991273289 0.31496062992126 28.2 28 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.311390461513883 0.463018418740079 1.02553483528966 0.3125 28.2 28 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.311390461513883 0.463018418740079 1.02553483528966 0.3125 28.2 28 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.311390461513883 0.463018418740079 1.02553483528966 0.3125 28.2 28 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0295644184981929 0.0659407014465963 1.02217242599363 0.311475409836066 28.2 28 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.162427444534594 0.274180609220317 1.01576783685833 0.30952380952381 28.2 28 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0582154310808995 0.115376822323287 1.01244290122214 0.308510638297872 28.2 28 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.201533478814366 0.329634644083728 1.00274517228323 0.305555555555556 28.2 28 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.167328426356396 0.278647714550418 0.998781752629933 0.304347826086957 28.2 28 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.225259469054144 0.359635897930213 0.994458022099067 0.303030303030303 28.2 28 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.317274141487455 0.470783215158131 0.984513441878077 0.3 28.2 28 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.317274141487455 0.470783215158131 0.984513441878077 0.3 28.2 28 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.252487197559666 0.384678032256323 0.984513441878076 0.3 28.2 28 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.189867209798801 0.311268478736975 0.977531077042062 0.297872340425532 28.2 28 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.229978248924899 0.359635897930213 0.975643951410706 0.297297297297297 28.2 28 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.229978248924899 0.359635897930213 0.975643951410706 0.297297297297297 28.2 28 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.147028525835949 0.249997075444236 0.97425809352518 0.296875 28.2 28 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0334766125739124 0.0740858782156724 0.973065611158564 0.296511627906977 28.2 28 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.17506427075927 0.291023898703786 0.97235895494131 0.296296296296296 28.2 28 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.28395219831915 0.424883257842429 0.97235895494131 0.296296296296296 28.2 28 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.363374605889367 0.518118300782133 0.965209256743212 0.294117647058824 28.2 28 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.363374605889367 0.518118300782133 0.965209256743212 0.294117647058824 28.2 28 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.363374605889367 0.518118300782133 0.965209256743212 0.294117647058824 28.2 28 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.363374605889367 0.518118300782133 0.965209256743212 0.294117647058824 28.2 28 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.117929619881094 0.209767311363496 0.965209256743212 0.294117647058824 28.2 28 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.117929619881094 0.209767311363496 0.965209256743212 0.294117647058824 28.2 28 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.233675532185746 0.359635897930213 0.960500918905441 0.292682926829268 28.2 28 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.320628053569681 0.474769740093295 0.957165846270352 0.291666666666667 28.2 28 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.320628053569681 0.474769740093295 0.957165846270352 0.291666666666667 28.2 28 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.363843122047281 0.518267029702984 0.937631849407692 0.285714285714286 28.2 28 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0338186041409692 0.0747265119450297 0.935749054529363 0.285140562248996 28.2 28 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.290938880285187 0.434880280090148 0.925610928261439 0.282051282051282 28.2 28 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.363142671057513 0.518118300782133 0.918879212419538 0.28 28.2 28 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.363142671057513 0.518118300782133 0.918879212419538 0.28 28.2 28 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.206110854542536 0.336734495997736 0.913894334232814 0.278481012658228 28.2 28 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.415479278577704 0.574380795511015 0.911586520257478 0.277777777777778 28.2 28 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.415479278577704 0.574380795511015 0.911586520257478 0.277777777777778 28.2 28 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.361766234680144 0.518118300782133 0.905299716669496 0.275862068965517 28.2 28 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.410691800824565 0.572756701154418 0.89501221988916 0.272727272727273 28.2 28 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.35997835586534 0.517951289083521 0.89501221988916 0.272727272727273 28.2 28 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.35997835586534 0.517951289083521 0.89501221988916 0.272727272727273 28.2 28 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.406019937511046 0.572756701154418 0.883537704249556 0.269230769230769 28.2 28 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.401504066360317 0.570769516913817 0.875123059447179 0.266666666666667 28.2 28 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.401504066360317 0.570769516913817 0.875123059447179 0.266666666666667 28.2 28 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.466826558470943 0.626692634626558 0.86360828234919 0.263157894736842 28.2 28 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.466826558470943 0.626692634626558 0.86360828234919 0.263157894736842 28.2 28 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.457161355278423 0.614877701853683 0.856098645111371 0.260869565217391 28.2 28 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0217541504842893 0.0509986097844211 0.827631625123521 0.25219512195122 28.2 28 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.49084615882151 0.655844210331463 0.820427868231731 0.25 28.2 28 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.516677364132105 0.68330101223047 0.82042786823173 0.25 28.2 28 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.488745557167476 0.653651247978682 0.802196137826581 0.244444444444444 28.2 28 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.473555204923114 0.63512634929839 0.780515161128565 0.237837837837838 28.2 28 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.571607949945443 0.725600457424055 0.765732677016282 0.233333333333333 28.2 28 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.565114584145598 0.717998261820702 0.763188714634168 0.232558139534884 28.2 28 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.56477165686284 0.717998261820702 0.757318032213905 0.230769230769231 28.2 28 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.588948859842031 0.744438923139024 0.757318032213905 0.230769230769231 28.2 28 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.592919811019582 0.746659195646784 0.750105479526154 0.228571428571429 28.2 28 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.615413426673783 0.771179212959912 0.746428491881417 0.227450980392157 28.2 28 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.609657554183333 0.766380476680992 0.7458435165743 0.227272727272727 28.2 28 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.609634236326539 0.766380476680992 0.741031622918982 0.225806451612903 28.2 28 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.652225140388055 0.802195777587403 0.72543095717332 0.221052631578947 28.2 28 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.693666922025379 0.840074919184778 0.72037568917908 0.219512195121951 28.2 28 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.645773939605652 0.802195777587403 0.717874384702764 0.21875 28.2 28 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.652017609434696 0.802195777587403 0.713415537592809 0.217391304347826 28.2 28 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.691949706768825 0.8387090568416 0.706191076452629 0.215189873417722 28.2 28 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.708169018822052 0.856908600156276 0.690886625879352 0.210526315789474 28.2 28 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.691872884921233 0.8387090568416 0.690886625879352 0.210526315789474 28.2 28 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.740258347776825 0.868415192816507 0.677178557905555 0.206349206349206 28.2 28 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.738513244615833 0.867082794627336 0.669737035291208 0.204081632653061 28.2 28 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.768261117986777 0.893896623790011 0.665854501753289 0.202898550724638 28.2 28 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.816568717715622 0.935569472873857 0.59667481325944 0.181818181818182 28.2 28 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.873873853044814 0.986922613399024 0.591784036101576 0.180327868852459 28.2 28 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.862587955069964 0.97727918794949 0.546951912154487 0.166666666666667 28.2 28 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.969427930458973 1 0.530377611786169 0.161616161616162 28.2 28 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.994010649081802 1 0.529308302084987 0.161290322580645 28.2 28 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999399195453176 1 0.483939019049131 0.147465437788018 28.2 28 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999995932266617 1 0.473649078566772 0.144329896907216 28.2 28 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.981481314837612 1 0.462212883510834 0.140845070422535 28.2 28 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.440868040023768 0.134340890008396 28.2 28 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.980708208748882 1 0.410213934115865 0.125 28.2 28 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999043535688093 1 0.395020825444907 0.12037037037037 28.2 28 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.367931485210613 0.112115732368897 28.2 28 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999957531527 1 0.363332341645481 0.110714285714286 28.2 28 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.99217120273361 1 0.349118241800736 0.106382978723404 28.2 28 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999902787982909 1 0.291707686482393 0.0888888888888889 28.2 28 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999933564765 1 0.279691318715363 0.0852272727272727 28.2 28 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.105861660416997 0.032258064516129 28.2 28 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.000237004799188645 0.00185306499585407 4.30808950086059 1 29.1 29 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00354135079531273 0.0148215946521471 3.07720678632899 0.714285714285714 29.1 29 1 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00354135079531273 0.0148215946521471 3.07720678632899 0.714285714285714 29.1 29 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 1.30086103054739e-08 4.40744106302126e-07 2.87205966724039 0.666666666666667 29.1 29 1 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.000377449642393109 0.00262005288353851 2.87205966724039 0.666666666666667 29.1 29 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 1.17634640467036e-05 0.000142330522743217 2.87205966724039 0.666666666666667 29.1 29 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00221597720020011 0.00964322799964757 2.87205966724039 0.666666666666667 29.1 29 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 2.64287956607118e-05 0.000282768242294684 2.72089863212248 0.631578947368421 29.1 29 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.000146284571761642 0.0012173271673498 2.69255593803787 0.625 29.1 29 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.00797792509967905 0.0288136736468104 2.69255593803787 0.625 29.1 29 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.00797792509967905 0.0288136736468104 2.69255593803787 0.625 29.1 29 1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00465709612674186 0.0187735064825883 2.58485370051635 0.6 29.1 29 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00465709612674186 0.0187735064825883 2.58485370051635 0.6 29.1 29 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.00465709612674186 0.0187735064825883 2.58485370051635 0.6 29.1 29 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 3.83009083997319e-06 5.92415137530635e-05 2.5529419264359 0.592592592592593 29.1 29 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.63935140812169e-12 2.68271218125511e-10 2.53014780209272 0.587301587301587 29.1 29 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 2.01499126000624e-05 0.000225774217558179 2.51305220883534 0.583333333333333 29.1 29 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00017670074789693 0.00142866570600757 2.4941570794456 0.578947368421053 29.1 29 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.21930656722009e-05 0.000145804474382705 2.48543625049649 0.576923076923077 29.1 29 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.11660198469113e-10 1.11552763859832e-08 2.46176542906319 0.571428571428571 29.1 29 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00159536068196499 0.00739478257471067 2.46176542906319 0.571428571428571 29.1 29 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00159536068196499 0.00739478257471067 2.46176542906319 0.571428571428571 29.1 29 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00159536068196499 0.00739478257471067 2.46176542906319 0.571428571428571 29.1 29 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 3.20845607670416e-07 7.73836101211868e-06 2.44513187886682 0.567567567567568 29.1 29 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.43106243173936e-08 4.73581823340722e-07 2.43500710918207 0.565217391304348 29.1 29 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00093726369606841 0.0050931411451513 2.42330034423408 0.5625 29.1 29 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00093726369606841 0.0050931411451513 2.42330034423408 0.5625 29.1 29 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.62064927288578e-06 3.11646475042766e-05 2.40746177989268 0.558823529411765 29.1 29 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000551980899814392 0.00357031282016309 2.39338305603366 0.555555555555556 29.1 29 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.000551980899814392 0.00357031282016309 2.39338305603366 0.555555555555556 29.1 29 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0151803599740277 0.047791266024428 2.39338305603366 0.555555555555556 29.1 29 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0151803599740277 0.047791266024428 2.39338305603366 0.555555555555556 29.1 29 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0151803599740277 0.047791266024428 2.39338305603366 0.555555555555556 29.1 29 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0151803599740277 0.047791266024428 2.39338305603366 0.555555555555556 29.1 29 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0151803599740277 0.047791266024428 2.39338305603366 0.555555555555556 29.1 29 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0151803599740277 0.047791266024428 2.39338305603366 0.555555555555556 29.1 29 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.000325805568026118 0.00240668086435958 2.36944922547332 0.55 29.1 29 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000325805568026118 0.00240668086435958 2.36944922547332 0.55 29.1 29 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 2.14409145515581e-07 5.54734934670313e-06 2.35919186951889 0.547619047619048 29.1 29 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000192695395153307 0.00153187456593942 2.34986700046941 0.545454545454545 29.1 29 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00862015344400125 0.0302629691502455 2.34986700046941 0.545454545454545 29.1 29 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.00862015344400125 0.0302629691502455 2.34986700046941 0.545454545454545 29.1 29 1 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.00862015344400125 0.0302629691502455 2.34986700046941 0.545454545454545 29.1 29 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00862015344400125 0.0302629691502455 2.34986700046941 0.545454545454545 29.1 29 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00494332892632158 0.0190632982714244 2.31974050046339 0.538461538461538 29.1 29 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00494332892632158 0.0190632982714244 2.31974050046339 0.538461538461538 29.1 29 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00494332892632158 0.0190632982714244 2.31974050046339 0.538461538461538 29.1 29 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00494332892632158 0.0190632982714244 2.31974050046339 0.538461538461538 29.1 29 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 4.02744237689102e-05 0.000400772762399715 2.30790508974674 0.535714285714286 29.1 29 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00285595810290114 0.0121314280012786 2.29764773379231 0.533333333333333 29.1 29 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 8.22123619805129e-08 2.48911044889936e-06 2.28592504127296 0.530612244897959 29.1 29 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.87961605439787e-12 2.22891137117347e-10 2.28075326516149 0.529411764705882 29.1 29 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00165963165636175 0.00754522634825168 2.28075326516149 0.529411764705882 29.1 29 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00165963165636175 0.00754522634825168 2.28075326516149 0.529411764705882 29.1 29 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00165963165636175 0.00754522634825168 2.28075326516149 0.529411764705882 29.1 29 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00165963165636175 0.00754522634825168 2.28075326516149 0.529411764705882 29.1 29 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 5.08646931653418e-06 7.70004876322142e-05 2.27371390323198 0.527777777777778 29.1 29 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000968958846389349 0.00522062509189922 2.26741552676873 0.526315789473684 29.1 29 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 2.4285165792249e-05 0.000263799930705117 2.21931883377667 0.515151515151515 29.1 29 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.09558473719792e-11 2.77524622906316e-09 2.15404475043029 0.5 29.1 29 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 3.01116625641969e-06 5.11207067449518e-05 2.15404475043029 0.5 29.1 29 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 8.44978012534329e-06 0.000104556844507509 2.15404475043029 0.5 29.1 29 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.000113827133100869 0.001004334366947 2.15404475043029 0.5 29.1 29 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000325983300314879 0.00240668086435958 2.15404475043029 0.5 29.1 29 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00161211212475258 0.00742406328000947 2.15404475043029 0.5 29.1 29 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00161211212475258 0.00742406328000947 2.15404475043029 0.5 29.1 29 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00477465250973387 0.0188731403370869 2.15404475043029 0.5 29.1 29 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00477465250973387 0.0188731403370869 2.15404475043029 0.5 29.1 29 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00477465250973387 0.0188731403370869 2.15404475043029 0.5 29.1 29 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00477465250973387 0.0188731403370869 2.15404475043029 0.5 29.1 29 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00477465250973387 0.0188731403370869 2.15404475043029 0.5 29.1 29 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0257036238213136 0.0747980709565016 2.15404475043029 0.5 29.1 29 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0257036238213136 0.0747980709565016 2.15404475043029 0.5 29.1 29 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0257036238213136 0.0747980709565016 2.15404475043029 0.5 29.1 29 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0257036238213136 0.0747980709565016 2.15404475043029 0.5 29.1 29 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0257036238213136 0.0747980709565016 2.15404475043029 0.5 29.1 29 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0257036238213136 0.0747980709565016 2.15404475043029 0.5 29.1 29 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00829129717067816 0.0294962896846876 2.15404475043029 0.5 29.1 29 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00829129717067816 0.0294962896846876 2.15404475043029 0.5 29.1 29 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00829129717067816 0.0294962896846876 2.15404475043029 0.5 29.1 29 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00829129717067816 0.0294962896846876 2.15404475043029 0.5 29.1 29 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00829129717067816 0.0294962896846876 2.15404475043029 0.5 29.1 29 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0145178203176912 0.0466339916751119 2.15404475043029 0.5 29.1 29 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0145178203176912 0.0466339916751119 2.15404475043029 0.5 29.1 29 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0145178203176912 0.0466339916751119 2.15404475043029 0.5 29.1 29 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0145178203176912 0.0466339916751119 2.15404475043029 0.5 29.1 29 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.09860238514524e-10 6.01273536177566e-09 2.12928561536788 0.494252873563218 29.1 29 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.75190704960676e-08 5.6658266627055e-07 2.12189482878208 0.492537313432836 29.1 29 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.91362744969304e-10 1.48074709318328e-08 2.1039506864668 0.488372093023256 29.1 29 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 8.10612469283047e-06 0.000101184345946472 2.1039506864668 0.488372093023256 29.1 29 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.35781812079761e-05 0.000158375015237295 2.10150707359053 0.48780487804878 29.1 29 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.35781812079761e-05 0.000158375015237295 2.10150707359053 0.48780487804878 29.1 29 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.11310051874863e-11 3.62455918257471e-09 2.08602228462723 0.484210526315789 29.1 29 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 6.11310051874863e-11 3.62455918257471e-09 2.08602228462723 0.484210526315789 29.1 29 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 6.11310051874863e-11 3.62455918257471e-09 2.08602228462723 0.484210526315789 29.1 29 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000882987759146058 0.00495487388959445 2.06788296041308 0.48 29.1 29 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0015015239641783 0.0070750615928004 2.06039063084637 0.478260869565217 29.1 29 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0015015239641783 0.0070750615928004 2.06039063084637 0.478260869565217 29.1 29 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0043857736227769 0.0179337812218722 2.04067397409186 0.473684210526316 29.1 29 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.86854536172584e-11 1.44528405462142e-09 2.03437559762861 0.472222222222222 29.1 29 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 2.55267741948688e-06 4.59805059231623e-05 2.03211768908518 0.471698113207547 29.1 29 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000168591310994482 0.00137088820311513 2.0273362356991 0.470588235294118 29.1 29 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000168591310994482 0.00137088820311513 2.0273362356991 0.470588235294118 29.1 29 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00754355993495355 0.0275950791450871 2.0273362356991 0.470588235294118 29.1 29 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00754355993495355 0.0275950791450871 2.0273362356991 0.470588235294118 29.1 29 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00754355993495355 0.0275950791450871 2.0273362356991 0.470588235294118 29.1 29 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000283479414213416 0.00215717222687536 2.0194169535284 0.46875 29.1 29 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.18025310496835e-05 0.000142330522743217 2.01655253231772 0.468085106382979 29.1 29 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0130472188549831 0.0429772972931503 2.01044176706827 0.466666666666667 29.1 29 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0130472188549831 0.0429772972931503 2.01044176706827 0.466666666666667 29.1 29 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0130472188549831 0.0429772972931503 2.01044176706827 0.466666666666667 29.1 29 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0130472188549831 0.0429772972931503 2.01044176706827 0.466666666666667 29.1 29 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 3.28450437244801e-05 0.000336248181438383 2.00376255853981 0.465116279069767 29.1 29 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.51226260772936e-10 1.72343092786168e-08 2.00173855595542 0.464646464646465 29.1 29 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000805109299089495 0.00460108647632269 2.00018441111384 0.464285714285714 29.1 29 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 5.48439133457463e-05 0.00053090400470066 1.996431719911 0.463414634146341 29.1 29 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00136042015242993 0.00649623448626773 1.98834900039719 0.461538461538462 29.1 29 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0227245272245795 0.0677924575274142 1.98834900039719 0.461538461538462 29.1 29 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0227245272245795 0.0677924575274142 1.98834900039719 0.461538461538462 29.1 29 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.57184955903474e-07 4.30142677405084e-06 1.97454102122777 0.458333333333333 29.1 29 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00230356913719633 0.00996346164811664 1.97454102122777 0.458333333333333 29.1 29 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00230356913719633 0.00996346164811664 1.97454102122777 0.458333333333333 29.1 29 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.000256473828435556 0.00198349053186846 1.96941234325055 0.457142857142857 29.1 29 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.03131982378273e-11 1.44528405462142e-09 1.95822250039118 0.454545454545455 29.1 29 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.03131982378273e-11 1.44528405462142e-09 1.95822250039118 0.454545454545455 29.1 29 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.95842107738755e-05 0.000486609185732585 1.95822250039118 0.454545454545455 29.1 29 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00390997660098931 0.0162214095887196 1.95822250039118 0.454545454545455 29.1 29 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0399398491357406 0.1090871503266 1.95822250039118 0.454545454545455 29.1 29 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0399398491357406 0.1090871503266 1.95822250039118 0.454545454545455 29.1 29 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0399398491357406 0.1090871503266 1.95822250039118 0.454545454545455 29.1 29 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0399398491357406 0.1090871503266 1.95822250039118 0.454545454545455 29.1 29 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0399398491357406 0.1090871503266 1.95822250039118 0.454545454545455 29.1 29 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0399398491357406 0.1090871503266 1.95822250039118 0.454545454545455 29.1 29 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.35077168240748e-07 5.97347875726042e-06 1.94749251408766 0.452054794520548 29.1 29 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.84179468195326e-11 1.44528405462142e-09 1.94558880684026 0.451612903225806 29.1 29 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.84179468195326e-11 1.44528405462142e-09 1.94558880684026 0.451612903225806 29.1 29 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.84179468195326e-11 1.44528405462142e-09 1.94558880684026 0.451612903225806 29.1 29 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.000720393379427217 0.00420131056936446 1.94558880684026 0.451612903225806 29.1 29 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.19728945910099e-06 5.11207067449518e-05 1.93864027538726 0.45 29.1 29 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.19728945910099e-06 5.11207067449518e-05 1.93864027538726 0.45 29.1 29 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.19728945910099e-06 5.11207067449518e-05 1.93864027538726 0.45 29.1 29 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.19728945910099e-06 5.11207067449518e-05 1.93864027538726 0.45 29.1 29 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.19728945910099e-06 5.11207067449518e-05 1.93864027538726 0.45 29.1 29 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.19728945910099e-06 5.11207067449518e-05 1.93864027538726 0.45 29.1 29 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.19728945910099e-06 5.11207067449518e-05 1.93864027538726 0.45 29.1 29 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00665513303025136 0.0248328138625242 1.93864027538726 0.45 29.1 29 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00665513303025136 0.0248328138625242 1.93864027538726 0.45 29.1 29 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00665513303025136 0.0248328138625242 1.93864027538726 0.45 29.1 29 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00665513303025136 0.0248328138625242 1.93864027538726 0.45 29.1 29 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00665513303025136 0.0248328138625242 1.93864027538726 0.45 29.1 29 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00120925025539995 0.00587291164994585 1.93121253486854 0.448275862068966 29.1 29 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00120925025539995 0.00587291164994585 1.93121253486854 0.448275862068966 29.1 29 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00120925025539995 0.00587291164994585 1.93121253486854 0.448275862068966 29.1 29 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.73511580935447e-06 3.24877604830448e-05 1.92207070038395 0.446153846153846 29.1 29 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00203223955731172 0.00903120674422002 1.91470644482693 0.444444444444444 29.1 29 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00203223955731172 0.00903120674422002 1.91470644482693 0.444444444444444 29.1 29 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 7.3505132662801e-05 0.000679206518046531 1.91470644482693 0.444444444444444 29.1 29 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000381337332036401 0.00263418943440679 1.91470644482693 0.444444444444444 29.1 29 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0113645819525891 0.0384933045184183 1.91470644482693 0.444444444444444 29.1 29 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0113645819525891 0.0384933045184183 1.91470644482693 0.444444444444444 29.1 29 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0113645819525891 0.0384933045184183 1.91470644482693 0.444444444444444 29.1 29 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0113645819525891 0.0384933045184183 1.91470644482693 0.444444444444444 29.1 29 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.77810840835905e-18 6.32562066273732e-16 1.91255991293811 0.443946188340807 29.1 29 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 9.40198389687448e-07 1.95472148872344e-05 1.90786820752397 0.442857142857143 29.1 29 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.17125250003431e-06 6.38246484682669e-05 1.88478915662651 0.4375 29.1 29 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00106021535237128 0.00527512743505012 1.88478915662651 0.4375 29.1 29 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0194814371235103 0.059489452847114 1.88478915662651 0.4375 29.1 29 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0194814371235103 0.059489452847114 1.88478915662651 0.4375 29.1 29 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0194814371235103 0.059489452847114 1.88478915662651 0.4375 29.1 29 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.000334871968477299 0.00240668086435958 1.87788516704179 0.435897435897436 29.1 29 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.000334871968477299 0.00240668086435958 1.87788516704179 0.435897435897436 29.1 29 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.9363555504192e-09 1.12930647249906e-07 1.86295762199377 0.432432432432432 29.1 29 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00295258725097839 0.0125045585063758 1.84632407179739 0.428571428571429 29.1 29 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0097254349421453 0.0337543754211531 1.84632407179739 0.428571428571429 29.1 29 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0335494497650053 0.093978084676383 1.84632407179739 0.428571428571429 29.1 29 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0335494497650053 0.093978084676383 1.84632407179739 0.428571428571429 29.1 29 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0335494497650053 0.093978084676383 1.84632407179739 0.428571428571429 29.1 29 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.60940098091331e-05 0.000186193300474767 1.83623486921927 0.426229508196721 29.1 29 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000480833351742245 0.00321500001963459 1.83093803786575 0.425 29.1 29 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000480833351742245 0.00321500001963459 1.83093803786575 0.425 29.1 29 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00152485916015979 0.00713774534509006 1.82767433369843 0.424242424242424 29.1 29 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00152485916015979 0.00713774534509006 1.82767433369843 0.424242424242424 29.1 29 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00492990826946492 0.0190632982714244 1.82265325036409 0.423076923076923 29.1 29 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00492990826946492 0.0190632982714244 1.82265325036409 0.423076923076923 29.1 29 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00492990826946492 0.0190632982714244 1.82265325036409 0.423076923076923 29.1 29 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.52129229368774e-19 2.50539946695883e-16 1.82143489926091 0.422794117647059 29.1 29 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000252236314572993 0.00196137855539546 1.81897112258558 0.422222222222222 29.1 29 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0164400789197252 0.0516428969156047 1.81393242141498 0.421052631578947 29.1 29 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 7.44136778788436e-06 9.37085518775172e-05 1.8106463119559 0.420289855072464 29.1 29 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000132746283510907 0.00111773941678118 1.80939759036145 0.42 29.1 29 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00252622375399498 0.0107952444502548 1.80661817778025 0.419354838709677 29.1 29 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.57058596449154e-12 2.68271218125511e-10 1.80338630268583 0.418604651162791 29.1 29 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 3.94524797386906e-09 1.43950970943992e-07 1.80092266019582 0.418032786885246 29.1 29 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.70545027325108e-05 0.000376632552774021 1.79503729202524 0.416666666666667 29.1 29 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.43371989606014e-06 9.37085518775172e-05 1.79503729202524 0.416666666666667 29.1 29 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00823339200278999 0.0294962896846876 1.79503729202524 0.416666666666667 29.1 29 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0580984411486329 0.14816143683603 1.79503729202524 0.416666666666667 29.1 29 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0580984411486329 0.14816143683603 1.79503729202524 0.416666666666667 29.1 29 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0580984411486329 0.14816143683603 1.79503729202524 0.416666666666667 29.1 29 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0580984411486329 0.14816143683603 1.79503729202524 0.416666666666667 29.1 29 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0580984411486329 0.14816143683603 1.79503729202524 0.416666666666667 29.1 29 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 9.75300250873957e-07 1.95472148872344e-05 1.78265772449404 0.413793103448276 29.1 29 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 9.75300250873957e-07 1.95472148872344e-05 1.78265772449404 0.413793103448276 29.1 29 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 6.02350047436732e-05 0.000571429411668313 1.78265772449404 0.413793103448276 29.1 29 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 6.02350047436732e-05 0.000571429411668313 1.78265772449404 0.413793103448276 29.1 29 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.95237584251157e-06 5.11207067449518e-05 1.77708691910499 0.4125 29.1 29 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000185854612859296 0.00149144162752591 1.77391920623671 0.411764705882353 29.1 29 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00214726469703869 0.00937287626958914 1.77391920623671 0.411764705882353 29.1 29 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0278379511554999 0.0795449889443301 1.77391920623671 0.411764705882353 29.1 29 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0278379511554999 0.0795449889443301 1.77391920623671 0.411764705882353 29.1 29 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.10757700758881e-09 1.46127052044972e-07 1.7699902600435 0.410852713178295 29.1 29 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00111069965034908 0.00545008828429912 1.76742133368639 0.41025641025641 29.1 29 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 4.64708909064153e-16 7.34756419553656e-14 1.7647595545694 0.409638554216867 29.1 29 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0137515214860225 0.0446767467456851 1.76240025035206 0.409090909090909 29.1 29 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000158594098646183 0.0013045052160319 1.75514757442468 0.407407407407407 29.1 29 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00692205550907025 0.025584636336122 1.75514757442468 0.407407407407407 29.1 29 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00692205550907025 0.025584636336122 1.75514757442468 0.407407407407407 29.1 29 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 4.40869255417714e-05 0.000435664548930144 1.75016135972461 0.40625 29.1 29 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.54739573579383e-16 5.01469272118602e-14 1.74964554441081 0.406130268199234 29.1 29 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.33290934181676e-05 0.000255363845646557 1.74821023223328 0.405797101449275 29.1 29 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00181626266695238 0.00812748985872085 1.74652277061916 0.405405405405405 29.1 29 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00181626266695238 0.00812748985872085 1.74652277061916 0.405405405405405 29.1 29 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00181626266695238 0.00812748985872085 1.74652277061916 0.405405405405405 29.1 29 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000941318426686432 0.0050931411451513 1.74375051225309 0.404761904761905 29.1 29 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000941318426686432 0.0050931411451513 1.74375051225309 0.404761904761905 29.1 29 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000941318426686432 0.0050931411451513 1.74375051225309 0.404761904761905 29.1 29 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.000490565466249286 0.00324685887661737 1.74156809609258 0.404255319148936 29.1 29 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 7.10965933205791e-05 0.000661244786243033 1.73713286325024 0.403225806451613 29.1 29 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.75619269079331e-05 0.000379082425460913 1.73609576900352 0.402985074626866 29.1 29 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.98881002078739e-05 0.000224609258696861 1.7352027156244 0.402777777777778 29.1 29 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.98881002078739e-05 0.000224609258696861 1.7352027156244 0.402777777777778 29.1 29 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 5.60554282437076e-06 8.39651309376798e-05 1.73374333571219 0.402439024390244 29.1 29 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 8.47450224355228e-07 1.79988308844401e-05 1.73211845910889 0.402061855670103 29.1 29 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.00079509835289014 0.00456219740388173 1.72323580034423 0.4 29.1 29 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 7.22670698013798e-07 1.55812182314187e-05 1.72323580034423 0.4 29.1 29 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 3.19301932661022e-05 0.00032925119578017 1.72323580034423 0.4 29.1 29 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000114472584285535 0.001004334366947 1.72323580034423 0.4 29.1 29 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0114424931913499 0.0384933045184183 1.72323580034423 0.4 29.1 29 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0114424931913499 0.0384933045184183 1.72323580034423 0.4 29.1 29 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0114424931913499 0.0384933045184183 1.72323580034423 0.4 29.1 29 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0114424931913499 0.0384933045184183 1.72323580034423 0.4 29.1 29 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0114424931913499 0.0384933045184183 1.72323580034423 0.4 29.1 29 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0229633761793744 0.068218965142484 1.72323580034423 0.4 29.1 29 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0472176037050203 0.125122253393378 1.72323580034423 0.4 29.1 29 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0472176037050203 0.125122253393378 1.72323580034423 0.4 29.1 29 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0472176037050203 0.125122253393378 1.72323580034423 0.4 29.1 29 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0472176037050203 0.125122253393378 1.72323580034423 0.4 29.1 29 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0472176037050203 0.125122253393378 1.72323580034423 0.4 29.1 29 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.70892099371105e-05 0.000287671236869465 1.71143281541037 0.397260273972603 29.1 29 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 9.69127744921977e-05 0.000889721794209015 1.70955932573833 0.396825396825397 29.1 29 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 8.69357196536891e-10 3.86592278334999e-08 1.70697885883155 0.39622641509434 29.1 29 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000669798827398187 0.00392231988225358 1.70528542742398 0.395833333333333 29.1 29 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 6.47358879342524e-06 9.37085518775172e-05 1.70319817475884 0.395348837209302 29.1 29 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.37784328344811e-09 5.7666793892549e-08 1.70128375193221 0.394904458598726 29.1 29 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00483215706708409 0.0189949157637035 1.69712616700569 0.393939393939394 29.1 29 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00483215706708409 0.0189949157637035 1.69712616700569 0.393939393939394 29.1 29 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.17150351754945e-09 5.0516651680996e-08 1.69631024096386 0.39375 29.1 29 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00949053497018849 0.0330479633545064 1.69246373248094 0.392857142857143 29.1 29 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00949053497018849 0.0330479633545064 1.69246373248094 0.392857142857143 29.1 29 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.81922289314745e-16 5.01469272118602e-14 1.69088837064494 0.392491467576792 29.1 29 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.000563030209365177 0.0036089729185885 1.68944686308258 0.392156862745098 29.1 29 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.000563030209365177 0.0036089729185885 1.68944686308258 0.392156862745098 29.1 29 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00107843372927914 0.00532851109987577 1.68577415251066 0.391304347826087 29.1 29 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.018887235849956 0.0581743216763796 1.68577415251066 0.391304347826087 29.1 29 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.018887235849956 0.0581743216763796 1.68577415251066 0.391304347826087 29.1 29 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.018887235849956 0.0581743216763796 1.68577415251066 0.391304347826087 29.1 29 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000130775498178367 0.00110769960659414 1.68284746127367 0.390625 29.1 29 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00207606337905869 0.00908996365661699 1.68120565887242 0.390243902439024 29.1 29 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00207606337905869 0.00908996365661699 1.68120565887242 0.390243902439024 29.1 29 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00207606337905869 0.00908996365661699 1.68120565887242 0.390243902439024 29.1 29 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00207606337905869 0.00908996365661699 1.68120565887242 0.390243902439024 29.1 29 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.81989546089607e-05 0.000559575083841562 1.67536813922356 0.388888888888889 29.1 29 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00402194581538244 0.0166372933002593 1.67536813922356 0.388888888888889 29.1 29 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.038321004284625 0.106091029371637 1.67536813922356 0.388888888888889 29.1 29 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.038321004284625 0.106091029371637 1.67536813922356 0.388888888888889 29.1 29 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.000902630772848148 0.00501735777251138 1.67048368400717 0.387755102040816 29.1 29 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.37749989208317e-07 3.84349479693009e-06 1.65695750033099 0.384615384615385 29.1 29 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000754426809443128 0.00438183408096968 1.65695750033099 0.384615384615385 29.1 29 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0802071373511664 0.195102147778991 1.65695750033099 0.384615384615385 29.1 29 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0802071373511664 0.195102147778991 1.65695750033099 0.384615384615385 29.1 29 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0802071373511664 0.195102147778991 1.65695750033099 0.384615384615385 29.1 29 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0802071373511664 0.195102147778991 1.65695750033099 0.384615384615385 29.1 29 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0802071373511664 0.195102147778991 1.65695750033099 0.384615384615385 29.1 29 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0802071373511664 0.195102147778991 1.65695750033099 0.384615384615385 29.1 29 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0802071373511664 0.195102147778991 1.65695750033099 0.384615384615385 29.1 29 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.47132231525646e-10 2.97054569503547e-08 1.64790308776088 0.382513661202186 29.1 29 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00649423329615984 0.0247093421936777 1.64721069150552 0.382352941176471 29.1 29 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.6666798456583e-06 3.16224722716235e-05 1.64490690032859 0.381818181818182 29.1 29 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000629844970763153 0.00370359253469407 1.64490690032859 0.381818181818182 29.1 29 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.000629844970763153 0.00370359253469407 1.64490690032859 0.381818181818182 29.1 29 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000629844970763153 0.00370359253469407 1.64490690032859 0.381818181818182 29.1 29 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000629844970763153 0.00370359253469407 1.64490690032859 0.381818181818182 29.1 29 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.000629844970763153 0.00370359253469407 1.64490690032859 0.381818181818182 29.1 29 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000629844970763153 0.00370359253469407 1.64490690032859 0.381818181818182 29.1 29 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 6.50262555783443e-05 0.000608765537420947 1.64387625690733 0.381578947368421 29.1 29 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000277001621160553 0.002119211327481 1.64117695270879 0.380952380952381 29.1 29 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0311098015561308 0.0885384952287482 1.64117695270879 0.380952380952381 29.1 29 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.000122553043026625 0.00106337183065175 1.63828755666529 0.380281690140845 29.1 29 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 5.44766372715285e-05 0.00053090400470066 1.63598335475718 0.379746835443038 29.1 29 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000525355205624306 0.00342926815414398 1.63410291411953 0.379310344827586 29.1 29 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.08496300693128e-07 3.08780471772644e-06 1.63091959675436 0.378571428571429 29.1 29 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.08496300693128e-07 3.08780471772644e-06 1.63091959675436 0.378571428571429 29.1 29 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000102500848994053 0.000911616925740856 1.63008791924455 0.378378378378378 29.1 29 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000102500848994053 0.000911616925740856 1.63008791924455 0.378378378378378 29.1 29 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 4.46255308049051e-07 1.02422790863516e-05 1.62825429953786 0.377952755905512 29.1 29 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000999294377484192 0.00522062509189922 1.62569415126815 0.377358490566038 29.1 29 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000437873776120502 0.00298131283932763 1.62436161507858 0.377049180327869 29.1 29 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000437873776120502 0.00298131283932763 1.62436161507858 0.377049180327869 29.1 29 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 5.39917996158082e-08 1.70734068562878e-06 1.61553356282272 0.375 29.1 29 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0638593036539263 0.161120193438896 1.61553356282272 0.375 29.1 29 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0638593036539263 0.161120193438896 1.61553356282272 0.375 29.1 29 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0638593036539263 0.161120193438896 1.61553356282272 0.375 29.1 29 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0638593036539263 0.161120193438896 1.61553356282272 0.375 29.1 29 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0638593036539263 0.161120193438896 1.61553356282272 0.375 29.1 29 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0638593036539263 0.161120193438896 1.61553356282272 0.375 29.1 29 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000830660937453589 0.00472812205598583 1.61553356282272 0.375 29.1 29 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0252795421582556 0.0744778229631423 1.61553356282272 0.375 29.1 29 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0252795421582556 0.0744778229631423 1.61553356282272 0.375 29.1 29 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.00013439280551182 0.00112494683672541 1.60835341365462 0.373333333333333 29.1 29 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00365623804852271 0.0152575564312253 1.60301004683185 0.372093023255814 29.1 29 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.0085794815609835 0.0302629691502455 1.60014752889107 0.371428571428571 29.1 29 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000573206619383796 0.00365298666590842 1.59816223419022 0.370967741935484 29.1 29 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.30285105613444e-19 2.51531901762644e-16 1.59783601205627 0.370892018779343 29.1 29 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00130920245468702 0.00627271075090784 1.59558870402244 0.37037037037037 29.1 29 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0205662724489738 0.0622676716912548 1.59558870402244 0.37037037037037 29.1 29 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0205662724489738 0.0622676716912548 1.59558870402244 0.37037037037037 29.1 29 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0205662724489738 0.0622676716912548 1.59558870402244 0.37037037037037 29.1 29 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.18111187097975e-06 2.33433637833914e-05 1.59433233496415 0.37007874015748 29.1 29 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.007044852765612 0.0259710504804815 1.58719086873811 0.368421052631579 29.1 29 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.05108487741415 0.133383083596946 1.58719086873811 0.368421052631579 29.1 29 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 9.86984863742421e-08 2.92599887730305e-06 1.58145057626528 0.367088607594937 29.1 29 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.83125532364902e-22 4.02887632555255e-19 1.5807248548785 0.366920152091255 29.1 29 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.0167525379630258 0.0523931022448037 1.57963281698221 0.366666666666667 29.1 29 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000100471546466433 0.000904879814061612 1.5711855826668 0.364705882352941 29.1 29 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000100471546466433 0.000904879814061612 1.5711855826668 0.364705882352941 29.1 29 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00169740673121496 0.00769238782967798 1.56657800031294 0.363636363636364 29.1 29 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00475571531147322 0.0188731403370869 1.56657800031294 0.363636363636364 29.1 29 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00475571531147322 0.0188731403370869 1.56657800031294 0.363636363636364 29.1 29 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0136626047045829 0.0444894427794542 1.56657800031294 0.363636363636364 29.1 29 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0136626047045829 0.0444894427794542 1.56657800031294 0.363636363636364 29.1 29 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0136626047045829 0.0444894427794542 1.56657800031294 0.363636363636364 29.1 29 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0136626047045829 0.0444894427794542 1.56657800031294 0.363636363636364 29.1 29 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0410288187390498 0.111632904523266 1.56657800031294 0.363636363636364 29.1 29 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 5.84777558812245e-10 2.77379488729941e-08 1.56482174694936 0.36322869955157 29.1 29 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.62882916695225e-07 4.37325265013785e-06 1.56168244406196 0.3625 29.1 29 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00140151988040547 0.00667010966493977 1.55982550893228 0.362068965517241 29.1 29 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00391000947922053 0.0162214095887196 1.55824513860915 0.361702127659574 29.1 29 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0111554800258885 0.0383435943885007 1.55569898642188 0.361111111111111 29.1 29 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0111554800258885 0.0383435943885007 1.55569898642188 0.361111111111111 29.1 29 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.0111554800258885 0.0383435943885007 1.55569898642188 0.361111111111111 29.1 29 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.000128993251981784 0.00110576745524144 1.55291598286835 0.36046511627907 29.1 29 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 0.000349612772525328 0.00243872046717422 1.55091222030981 0.36 29.1 29 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 0.000349612772525328 0.00243872046717422 1.55091222030981 0.36 29.1 29 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 0.000349612772525328 0.00243872046717422 1.55091222030981 0.36 29.1 29 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 0.000349612772525328 0.00243872046717422 1.55091222030981 0.36 29.1 29 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 0.000349612772525328 0.00243872046717422 1.55091222030981 0.36 29.1 29 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.03306288220214 0.0931653096507827 1.55091222030981 0.36 29.1 29 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.03306288220214 0.0931653096507827 1.55091222030981 0.36 29.1 29 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.03306288220214 0.0931653096507827 1.55091222030981 0.36 29.1 29 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.45695458124109e-06 2.84006351932339e-05 1.54967248232395 0.359712230215827 29.1 29 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.23730112997347e-05 0.000146723292329354 1.54940060995863 0.359649122807018 29.1 29 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.81957762985415e-07 9.05876494547076e-06 1.54649366697559 0.358974358974359 29.1 29 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000289546311246695 0.00219161915374493 1.54649366697559 0.358974358974359 29.1 29 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0026466415970286 0.0112759610556039 1.54440944370474 0.358490566037736 29.1 29 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 5.80509944968729e-15 8.26065651690502e-13 1.54354008854363 0.358288770053476 29.1 29 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.000789816532182453 0.00455228516125646 1.54319623911424 0.358208955223881 29.1 29 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.28259766930081e-05 0.000251793525846128 1.54142651865654 0.357798165137615 29.1 29 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 8.51946792863703e-11 4.8492811449802e-09 1.54097047530782 0.357692307692308 29.1 29 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.106128074899034 0.232338847048192 1.53860339316449 0.357142857142857 29.1 29 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.106128074899034 0.232338847048192 1.53860339316449 0.357142857142857 29.1 29 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.106128074899034 0.232338847048192 1.53860339316449 0.357142857142857 29.1 29 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.106128074899034 0.232338847048192 1.53860339316449 0.357142857142857 29.1 29 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.106128074899034 0.232338847048192 1.53860339316449 0.357142857142857 29.1 29 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.106128074899034 0.232338847048192 1.53860339316449 0.357142857142857 29.1 29 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.82916581614508e-09 2.02314706253035e-07 1.53860339316449 0.357142857142857 29.1 29 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00179464161238123 0.00810722226799519 1.5333877884419 0.355932203389831 29.1 29 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000445906975543946 0.00302155060094779 1.53050548056889 0.355263157894737 29.1 29 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.0014787339939568 0.00701412824466842 1.52867691966021 0.354838709677419 29.1 29 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0216458049900286 0.0653969862012967 1.52867691966021 0.354838709677419 29.1 29 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.89847508919002e-05 0.000305520744586474 1.52741355030512 0.354545454545455 29.1 29 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.0003049023997195 0.00229564081905211 1.52359262835313 0.353658536585366 29.1 29 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.65682420158048e-05 0.000190133938616857 1.52050217677432 0.352941176470588 29.1 29 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00410835730641016 0.016945485353686 1.52050217677432 0.352941176470588 29.1 29 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.9446768605291e-07 7.22461236643604e-06 1.52050217677432 0.352941176470588 29.1 29 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0835073141076133 0.199376900197132 1.52050217677432 0.352941176470588 29.1 29 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0835073141076133 0.199376900197132 1.52050217677432 0.352941176470588 29.1 29 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0835073141076133 0.199376900197132 1.52050217677432 0.352941176470588 29.1 29 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0835073141076133 0.199376900197132 1.52050217677432 0.352941176470588 29.1 29 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.57406459723434e-06 5.65099324651607e-05 1.51867903267747 0.352517985611511 29.1 29 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00337267998858547 0.0141991823188081 1.51580926882132 0.351851851851852 29.1 29 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 9.79119268910734e-05 0.000893132512602548 1.5078313253012 0.35 29.1 29 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0662272242328752 0.166798832005985 1.5078313253012 0.35 29.1 29 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.73619722285488e-06 5.8424270858489e-05 1.5063250003009 0.34965034965035 29.1 29 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 5.60325838630977e-07 1.26562487043156e-05 1.50400757722352 0.349112426035503 29.1 29 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.00949867674771125 0.0330479633545064 1.50282191890486 0.348837209302326 29.1 29 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00126928870885655 0.00610201970507724 1.49846591334281 0.347826086956522 29.1 29 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.84477750555969e-07 4.86133035261377e-06 1.49746426500502 0.347593582887701 29.1 29 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00104559251664882 0.00522062509189922 1.49586441002104 0.347222222222222 29.1 29 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.000148622300248274 0.00122959030961217 1.49464329621694 0.346938775510204 29.1 29 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00634553543159302 0.0242083027323241 1.49464329621694 0.346938775510204 29.1 29 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0423540710792876 0.114157264091275 1.49126175029789 0.346153846153846 29.1 29 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0423540710792876 0.114157264091275 1.49126175029789 0.346153846153846 29.1 29 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0423540710792876 0.114157264091275 1.49126175029789 0.346153846153846 29.1 29 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 0.000585979984489934 0.00365298666590842 1.48921612375428 0.345679012345679 29.1 29 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 0.000585979984489934 0.00365298666590842 1.48921612375428 0.345679012345679 29.1 29 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000585979984489934 0.00365298666590842 1.48921612375428 0.345679012345679 29.1 29 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.000483492624175546 0.00321500001963459 1.48731661339234 0.345238095238095 29.1 29 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.000483492624175546 0.00321500001963459 1.48731661339234 0.345238095238095 29.1 29 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0340802705664036 0.095277455827097 1.48554810374503 0.344827586206897 29.1 29 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.00032949268424213 0.00240668086435958 1.48389749474087 0.344444444444444 29.1 29 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.000272130792783261 0.00209320063854367 1.4823533766402 0.344086021505376 29.1 29 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.90741211097133e-06 3.47980440245154e-05 1.48007982851652 0.343558282208589 29.1 29 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0222647005572468 0.0668410736138444 1.47705925743791 0.342857142857143 29.1 29 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0222647005572468 0.0668410736138444 1.47705925743791 0.342857142857143 29.1 29 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.0222647005572468 0.0668410736138444 1.47705925743791 0.342857142857143 29.1 29 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.000126968275470447 0.00109500518784513 1.47705925743791 0.342857142857143 29.1 29 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0010779188861741 0.00532851109987577 1.47382009239967 0.342105263157895 29.1 29 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0180608838132052 0.0562377191820372 1.47382009239967 0.342105263157895 29.1 29 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 0.000887907829828942 0.00495487388959445 1.47238501928147 0.341772151898734 29.1 29 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 0.000887907829828942 0.00495487388959445 1.47238501928147 0.341772151898734 29.1 29 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.000887907829828942 0.00495487388959445 1.47238501928147 0.341772151898734 29.1 29 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0146796381471015 0.0468366033258417 1.47105495151337 0.341463414634146 29.1 29 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0146796381471015 0.0468366033258417 1.47105495151337 0.341463414634146 29.1 29 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0146796381471015 0.0468366033258417 1.47105495151337 0.341463414634146 29.1 29 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000603269055859789 0.00365298666590842 1.46981877088185 0.341176470588235 29.1 29 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000497562154131098 0.00327792104318774 1.46866687529338 0.340909090909091 29.1 29 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00795763555999513 0.0288136736468104 1.4647504302926 0.34 29.1 29 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000130382940481669 0.00110769960659414 1.46237900487928 0.339449541284404 29.1 29 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.00436125571401852 0.0178849189655572 1.46036932232562 0.338983050847458 29.1 29 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.00436125571401852 0.0178849189655572 1.46036932232562 0.338983050847458 29.1 29 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 9.55578976868042e-07 1.95472148872344e-05 1.45957130630249 0.33879781420765 29.1 29 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00240958228214631 0.0103590199017952 1.45714791940873 0.338235294117647 29.1 29 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000616850750048406 0.00370359253469407 1.45216500029008 0.337078651685393 29.1 29 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000508696928265504 0.00333583285217425 1.45163885355085 0.33695652173913 29.1 29 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.000236115122829732 0.00185306499585407 1.44983781278962 0.336538461538462 29.1 29 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 9.44183625296722e-06 0.000115825284379072 1.4452945422242 0.335483870967742 29.1 29 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0532479703944445 0.137516990692005 1.4360298336202 0.333333333333333 29.1 29 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0532479703944445 0.137516990692005 1.4360298336202 0.333333333333333 29.1 29 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00660052192971416 0.0248328138625242 1.4360298336202 0.333333333333333 29.1 29 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0121146476558028 0.0405205788644336 1.4360298336202 0.333333333333333 29.1 29 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.0121146476558028 0.0405205788644336 1.4360298336202 0.333333333333333 29.1 29 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0427441368680923 0.114763975025086 1.4360298336202 0.333333333333333 29.1 29 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.066616723340722 0.166893657242689 1.4360298336202 0.333333333333333 29.1 29 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.066616723340722 0.166893657242689 1.4360298336202 0.333333333333333 29.1 29 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.066616723340722 0.166893657242689 1.4360298336202 0.333333333333333 29.1 29 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0837859355712474 0.199376900197132 1.4360298336202 0.333333333333333 29.1 29 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0837859355712474 0.199376900197132 1.4360298336202 0.333333333333333 29.1 29 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0837859355712474 0.199376900197132 1.4360298336202 0.333333333333333 29.1 29 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0837859355712474 0.199376900197132 1.4360298336202 0.333333333333333 29.1 29 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0837859355712474 0.199376900197132 1.4360298336202 0.333333333333333 29.1 29 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0837859355712474 0.199376900197132 1.4360298336202 0.333333333333333 29.1 29 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.13558331049604 0.274060900031275 1.4360298336202 0.333333333333333 29.1 29 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.13558331049604 0.274060900031275 1.4360298336202 0.333333333333333 29.1 29 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.13558331049604 0.274060900031275 1.4360298336202 0.333333333333333 29.1 29 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.13558331049604 0.274060900031275 1.4360298336202 0.333333333333333 29.1 29 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.98743720169367e-07 9.3018412098526e-06 1.43602983362019 0.333333333333333 29.1 29 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.11555788815092e-06 5.11207067449518e-05 1.43602983362019 0.333333333333333 29.1 29 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.106100469019108 0.232338847048192 1.43602983362019 0.333333333333333 29.1 29 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.106100469019108 0.232338847048192 1.43602983362019 0.333333333333333 29.1 29 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.106100469019108 0.232338847048192 1.43602983362019 0.333333333333333 29.1 29 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.106100469019108 0.232338847048192 1.43602983362019 0.333333333333333 29.1 29 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.78678348680173e-07 6.95718052933133e-06 1.42950242528556 0.331818181818182 29.1 29 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 6.41899319393838e-05 0.000604915716223464 1.42523261682606 0.330827067669173 29.1 29 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.08854972973964e-05 0.000232187989485899 1.41750041641219 0.329032258064516 29.1 29 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00246891506943956 0.0105821269391943 1.41713470423046 0.328947368421053 29.1 29 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.00445980006958607 0.0181322728543457 1.41459655252139 0.328358208955224 29.1 29 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.00445980006958607 0.0181322728543457 1.41459655252139 0.328358208955224 29.1 29 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0121590212052798 0.0405205788644336 1.40841387528135 0.326923076923077 29.1 29 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0121590212052798 0.0405205788644336 1.40841387528135 0.326923076923077 29.1 29 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0183150284153628 0.0567805782898939 1.40481179375889 0.326086956521739 29.1 29 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.000115043219825974 0.001004334366947 1.40339279194701 0.325757575757576 29.1 29 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0225328250409727 0.067503600070114 1.40263379097786 0.325581395348837 29.1 29 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00203725745951836 0.00903120674422002 1.40142670509923 0.325301204819277 29.1 29 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.07971981098465e-05 0.000319886225622712 1.39944308626681 0.32484076433121 29.1 29 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.87005835710955e-06 3.45596498982714e-05 1.39500040980248 0.323809523809524 29.1 29 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0424965164777418 0.11431482598833 1.39379366204313 0.323529411764706 29.1 29 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 5.7259950670672e-06 8.48759477128815e-05 1.39115390131956 0.322916666666667 29.1 29 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.000203575241867907 0.00160937538432239 1.39080054752192 0.322834645669291 29.1 29 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0527909615719323 0.136833403127249 1.38970629060019 0.32258064516129 29.1 29 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0527909615719323 0.136833403127249 1.38970629060019 0.32258064516129 29.1 29 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00300363255229619 0.0126829944270548 1.38284354348611 0.320987654320988 29.1 29 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.0181843376432844 0.0564984988349206 1.37858864027539 0.32 29.1 29 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0824067662294666 0.199376900197132 1.37858864027539 0.32 29.1 29 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0824067662294666 0.199376900197132 1.37858864027539 0.32 29.1 29 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0824067662294666 0.199376900197132 1.37858864027539 0.32 29.1 29 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.103739256759606 0.231263834542988 1.37075575027382 0.318181818181818 29.1 29 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.103739256759606 0.231263834542988 1.37075575027382 0.318181818181818 29.1 29 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.000930695349948684 0.0050931411451513 1.36892563578748 0.317757009345794 29.1 29 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.000930695349948684 0.0050931411451513 1.36892563578748 0.317757009345794 29.1 29 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00980913878504829 0.0339620547229288 1.36764746059066 0.317460317460317 29.1 29 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.000431178443012477 0.00296409142225486 1.36597959783384 0.317073170731707 29.1 29 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.131492280529088 0.27196731859432 1.36044931606124 0.315789473684211 29.1 29 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.50102860983159e-05 0.00026961846301442 1.35798473396692 0.315217391304348 29.1 29 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0079363147563833 0.0288136736468104 1.35397098598476 0.314285714285714 29.1 29 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0517694321079683 0.134676237458206 1.35397098598476 0.314285714285714 29.1 29 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0517694321079683 0.134676237458206 1.35397098598476 0.314285714285714 29.1 29 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.44846655153107e-17 4.12233580565744e-15 1.35144933125588 0.313700384122919 29.1 29 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.16818513178791 0.326059186013892 1.34627796901893 0.3125 29.1 29 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.16818513178791 0.326059186013892 1.34627796901893 0.3125 29.1 29 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.00110157355405474 0.00542401095993042 1.34627796901893 0.3125 29.1 29 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0800943332890208 0.195102147778991 1.33699329337053 0.310344827586207 29.1 29 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0800943332890208 0.195102147778991 1.33699329337053 0.310344827586207 29.1 29 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.00236005652687524 0.0101768498113438 1.33550774526678 0.31 29.1 29 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 0.00088288130903052 0.00495487388959445 1.33095447994067 0.308943089430894 29.1 29 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0140883629143079 0.0456668346857863 1.3255660002648 0.307692307692308 29.1 29 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0263442531870047 0.0763500453871848 1.3255660002648 0.307692307692308 29.1 29 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.10020796407399 0.227715559648949 1.3255660002648 0.307692307692308 29.1 29 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.10020796407399 0.227715559648949 1.3255660002648 0.307692307692308 29.1 29 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.10020796407399 0.227715559648949 1.3255660002648 0.307692307692308 29.1 29 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.039654455437923 0.1090871503266 1.31115767417496 0.304347826086957 29.1 29 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.126008704052811 0.264469595674262 1.31115767417496 0.304347826086957 29.1 29 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.11027374113619e-16 2.633199222728e-14 1.3011989782011 0.302036199095023 29.1 29 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.0313239072589512 0.0889699002584583 1.30055532101452 0.30188679245283 29.1 29 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.159463018941751 0.317312756982139 1.29242685025818 0.3 29.1 29 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.53343695192925e-09 6.23451652170094e-08 1.28807524470175 0.298989898989899 29.1 29 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.119980592991694 0.257514907733304 1.27647096321795 0.296296296296296 29.1 29 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.119980592991694 0.257514907733304 1.27647096321795 0.296296296296296 29.1 29 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.119980592991694 0.257514907733304 1.27647096321795 0.296296296296296 29.1 29 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.119980592991694 0.257514907733304 1.27647096321795 0.296296296296296 29.1 29 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.119980592991694 0.257514907733304 1.27647096321795 0.296296296296296 29.1 29 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.0190470368909989 0.0585398131660722 1.27422365518412 0.295774647887324 29.1 29 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0917457110723797 0.214727215223678 1.26708514731194 0.294117647058824 29.1 29 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.203467555821367 0.370248506309215 1.26708514731194 0.294117647058824 29.1 29 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.203467555821367 0.370248506309215 1.26708514731194 0.294117647058824 29.1 29 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.203467555821367 0.370248506309215 1.26708514731194 0.294117647058824 29.1 29 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.203467555821367 0.370248506309215 1.26708514731194 0.294117647058824 29.1 29 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.84172617815496e-09 7.27993430976253e-08 1.26661058358635 0.294007490636704 29.1 29 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.00773695621628209 0.0282299710147934 1.2619656113632 0.292929292929293 29.1 29 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.000338331963714472 0.00241932856465173 1.25652610441767 0.291666666666667 29.1 29 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.150464225522495 0.300295361737041 1.25652610441767 0.291666666666667 29.1 29 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.150464225522495 0.300295361737041 1.25652610441767 0.291666666666667 29.1 29 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 7.5603153035194e-08 2.33876710367568e-06 1.25572115495936 0.291479820627803 29.1 29 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0176708005625837 0.0551437482468346 1.25425390531384 0.291139240506329 29.1 29 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0269448790336812 0.0779084463403556 1.24872159445234 0.289855072463768 29.1 29 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0873266026471291 0.204721178858097 1.2470785397228 0.289473684210526 29.1 29 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0873266026471291 0.204721178858097 1.2470785397228 0.289473684210526 29.1 29 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0676582529881435 0.169205086119733 1.2445591891375 0.288888888888889 29.1 29 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.00863441003162311 0.0302629691502455 1.24271812524825 0.288461538461538 29.1 29 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0414307879036377 0.11251147173068 1.24131392397678 0.288135593220339 29.1 29 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0326541195233332 0.0925633706806836 1.24020758358108 0.287878787878788 29.1 29 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 0.0258291581749046 0.075009983842631 1.23931341805578 0.287671232876712 29.1 29 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.107736222658144 0.235497150295759 1.2308827145316 0.285714285714286 29.1 29 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.14164718741764 0.283892884077889 1.2308827145316 0.285714285714286 29.1 29 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.14164718741764 0.283892884077889 1.2308827145316 0.285714285714286 29.1 29 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.189733852289952 0.347857182842388 1.2308827145316 0.285714285714286 29.1 29 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.189733852289952 0.347857182842388 1.2308827145316 0.285714285714286 29.1 29 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.189733852289952 0.347857182842388 1.2308827145316 0.285714285714286 29.1 29 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0786900520230788 0.194402680605627 1.21750355459104 0.282608695652174 29.1 29 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0786900520230788 0.194402680605627 1.21750355459104 0.282608695652174 29.1 29 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.101840477890486 0.228578864413504 1.2151021669094 0.282051282051282 29.1 29 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.133203569961611 0.274060900031275 1.21165017211704 0.28125 29.1 29 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.176931015247561 0.332121907668954 1.20626506024096 0.28 29.1 29 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.18311150464022e-07 1.37477619860985e-05 1.19961028784126 0.278455284552846 29.1 29 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0706261488487508 0.17616179831666 1.19669152801683 0.277777777777778 29.1 29 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.000332853864290548 0.00240668086435958 1.19669152801683 0.277777777777778 29.1 29 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.000332853864290548 0.00240668086435958 1.19669152801683 0.277777777777778 29.1 29 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.000332853864290548 0.00240668086435958 1.19669152801683 0.277777777777778 29.1 29 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.125208813883051 0.26317893966851 1.19669152801683 0.277777777777778 29.1 29 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.240916435360698 0.414539404496099 1.19669152801683 0.277777777777778 29.1 29 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.240916435360698 0.414539404496099 1.19669152801683 0.277777777777778 29.1 29 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.0310770545435608 0.0885384952287482 1.19380793397342 0.27710843373494 29.1 29 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.117684088280774 0.255281185401741 1.18472461273666 0.275 29.1 29 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.0123328714472811 0.0410039160501894 1.18125034701016 0.274193548387097 29.1 29 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.221981825613832 0.397833926761313 1.17493350023471 0.272727272727273 29.1 29 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.221981825613832 0.397833926761313 1.17493350023471 0.272727272727273 29.1 29 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.221981825613832 0.397833926761313 1.17493350023471 0.272727272727273 29.1 29 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0423577199158069 0.114157264091275 1.17009838294979 0.271604938271605 29.1 29 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0566258044591581 0.14597557924888 1.16933857880502 0.271428571428571 29.1 29 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.10401184406712 0.231263834542988 1.16677423981641 0.270833333333333 29.1 29 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.10401184406712 0.231263834542988 1.16677423981641 0.270833333333333 29.1 29 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.0165431921726582 0.0518523402239925 1.16530289777376 0.270491803278689 29.1 29 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.000186561215530297 0.00149144162752591 1.16291986526298 0.269938650306748 29.1 29 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.027225645205162 0.0781090587236806 1.1598702502317 0.269230769230769 29.1 29 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0978231452992169 0.225246497994799 1.1598702502317 0.269230769230769 29.1 29 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.205197402522034 0.372919417354859 1.1598702502317 0.269230769230769 29.1 29 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0360316038482452 0.100142523976666 1.15808857550016 0.268817204301075 29.1 29 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.134831322380428 0.274060900031275 1.15582889047479 0.268292682926829 29.1 29 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.000790171774301016 0.00455228516125646 1.15089755618658 0.267148014440433 29.1 29 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.190184742270821 0.347857182842388 1.14882386689616 0.266666666666667 29.1 29 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.190184742270821 0.347857182842388 1.14882386689616 0.266666666666667 29.1 29 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.190184742270821 0.347857182842388 1.14882386689616 0.266666666666667 29.1 29 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0405736081608511 0.110605832208604 1.14576848427143 0.265957446808511 29.1 29 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 7.20467852536113e-07 1.55812182314187e-05 1.14569720784939 0.265940902021773 29.1 29 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.85468952474802e-14 2.39929381246949e-12 1.1430760392858 0.265332472562944 29.1 29 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.118305050858559 0.255848157099892 1.14296252063648 0.26530612244898 29.1 29 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.118305050858559 0.255848157099892 1.14296252063648 0.26530612244898 29.1 29 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.176659286384438 0.332121907668954 1.14037663258074 0.264705882352941 29.1 29 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.0246916555827361 0.0732004706129863 1.13932945477305 0.264462809917355 29.1 29 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.279996490657702 0.474892736836603 1.13370776338436 0.263157894736842 29.1 29 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.279996490657702 0.474892736836603 1.13370776338436 0.263157894736842 29.1 29 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0977598029976714 0.225246497994799 1.12999068875032 0.262295081967213 29.1 29 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.71909017221208e-09 1.39270139869942e-07 1.129849298524 0.262262262262262 29.1 29 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.153239654998606 0.305406203169491 1.1283091549873 0.261904761904762 29.1 29 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0571670747599651 0.147104425648156 1.12597793772493 0.261363636363636 29.1 29 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.143033650868523 0.286268474241785 1.12384943500711 0.260869565217391 29.1 29 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.255854692047133 0.43812421995556 1.12384943500711 0.260869565217391 29.1 29 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.235023285857654 0.412457124326461 1.11691209281571 0.259259259259259 29.1 29 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.117105646244513 0.254414251306781 1.11416107780877 0.258620689655172 29.1 29 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.117105646244513 0.254414251306781 1.11416107780877 0.258620689655172 29.1 29 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.117105646244513 0.254414251306781 1.11416107780877 0.258620689655172 29.1 29 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.216746554349589 0.391875857371073 1.11176503248015 0.258064516129032 29.1 29 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.0196276061422256 0.0598074594012571 1.10329121363503 0.25609756097561 29.1 29 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.94653509359165e-05 0.000395487284378938 1.10154302473843 0.25569176882662 29.1 29 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00520778794881431 0.0200288709490886 1.09814046100368 0.254901960784314 29.1 29 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.0948310120869456 0.219422000324754 1.09065556983812 0.253164556962025 29.1 29 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.136291152928946 0.274060900031275 1.07702237521515 0.25 29.1 29 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.20873829298735 0.378870651684948 1.07702237521515 0.25 29.1 29 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.244594215812248 0.41985231495878 1.07702237521515 0.25 29.1 29 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.320174314563019 0.522486295439421 1.07702237521515 0.25 29.1 29 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.320174314563019 0.522486295439421 1.07702237521515 0.25 29.1 29 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.225620088681652 0.403845768797472 1.07702237521515 0.25 29.1 29 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.266148652004325 0.453568301559467 1.07702237521515 0.25 29.1 29 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0251734748607699 0.0744737104508848 1.07120063264642 0.248648648648649 29.1 29 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.215381393460218 0.390430220246995 1.05308854465481 0.244444444444444 29.1 29 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.232579251247648 0.409604300155202 1.05075353679526 0.24390243902439 29.1 29 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.251816901630075 0.431729459059756 1.04791366237149 0.243243243243243 29.1 29 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.273526072549698 0.465027002674099 1.04438533354196 0.242424242424242 29.1 29 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.273526072549698 0.465027002674099 1.04438533354196 0.242424242424242 29.1 29 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.115181716535599 0.25138586292969 1.04301114231362 0.242105263157895 29.1 29 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.327001847231489 0.53179843269761 1.03394148020654 0.24 29.1 29 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.327001847231489 0.53179843269761 1.03394148020654 0.24 29.1 29 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.0986044457797342 0.226313107007358 1.01947156127235 0.236641221374046 29.1 29 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.0986044457797342 0.226313107007358 1.01947156127235 0.236641221374046 29.1 29 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.123121877233022 0.259175194234601 1.01827570020341 0.236363636363636 29.1 29 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.303331237523624 0.506620130277132 1.01366811784955 0.235294117647059 29.1 29 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.303331237523624 0.506620130277132 1.01366811784955 0.235294117647059 29.1 29 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.102177587542754 0.228740276587664 1.00827626615886 0.234042553191489 29.1 29 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.331206994557436 0.537408840655908 1.00522088353414 0.233333333333333 29.1 29 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0953105804064559 0.220173629737641 0.998215859955501 0.231707317073171 29.1 29 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.363543180644325 0.564146069854824 0.994174500198597 0.230769230769231 29.1 29 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.363543180644325 0.564146069854824 0.994174500198597 0.230769230769231 29.1 29 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.286016141446739 0.481196474677145 0.987270510613884 0.229166666666667 29.1 29 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.401806115908504 0.608974932569774 0.979111250195588 0.227272727272727 29.1 29 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.364591289618058 0.564541246057123 0.972794403420132 0.225806451612903 29.1 29 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.364591289618058 0.564541246057123 0.972794403420132 0.225806451612903 29.1 29 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.335317269748855 0.538652597162385 0.969320137693632 0.225 29.1 29 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.102233883281626 0.228740276587664 0.961462034526826 0.223175965665236 29.1 29 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 2.92064838325821e-05 0.000305594312454149 0.960388732630872 0.222926829268293 29.1 29 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.400263150583373 0.607906513100844 0.957353222413464 0.222222222222222 29.1 29 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.241473144043246 0.414995512045337 0.957353222413463 0.222222222222222 29.1 29 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.398190470283684 0.607906513100844 0.942394578313253 0.21875 29.1 29 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.398190470283684 0.607906513100844 0.942394578313253 0.21875 29.1 29 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.336242099065413 0.538652597162385 0.939946800187764 0.218181818181818 29.1 29 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.442348178092219 0.663988879140535 0.936541195839258 0.217391304347826 29.1 29 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.442348178092219 0.663988879140535 0.936541195839258 0.217391304347826 29.1 29 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.442348178092219 0.663988879140535 0.936541195839258 0.217391304347826 29.1 29 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.436839832014022 0.657802202069792 0.923162035898697 0.214285714285714 29.1 29 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.436839832014022 0.657802202069792 0.923162035898697 0.214285714285714 29.1 29 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.436839832014022 0.657802202069792 0.923162035898697 0.214285714285714 29.1 29 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.359307500797245 0.55879188375353 0.918117434609633 0.213114754098361 29.1 29 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.359307500797245 0.55879188375353 0.918117434609633 0.213114754098361 29.1 29 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.431753961981297 0.652214318364528 0.913837166849215 0.212121212121212 29.1 29 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.309847878961142 0.515085901590777 0.913837166849215 0.212121212121212 29.1 29 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.32752500995711 0.53204119768147 0.904698795180723 0.21 29.1 29 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.282765225852872 0.479017757605521 0.89861989588503 0.208588957055215 29.1 29 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.418359825233903 0.632652530614075 0.897518646012622 0.208333333333333 29.1 29 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.285195892760953 0.481196474677145 0.878512368802943 0.203921568627451 29.1 29 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.325924680696335 0.531260962921975 0.874738984946312 0.203045685279188 29.1 29 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.31913066452743 0.521980385773027 0.873529668377261 0.202764976958525 29.1 29 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.466619431739016 0.674796190411199 0.861617900172117 0.2 29.1 29 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.473286002047235 0.68374211260225 0.861617900172117 0.2 29.1 29 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.520975330062952 0.739868158362855 0.861617900172117 0.2 29.1 29 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.520975330062952 0.739868158362855 0.861617900172117 0.2 29.1 29 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.509118496944329 0.725200821973754 0.842887076255332 0.195652173913043 29.1 29 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.447653488166194 0.670210047194438 0.839941978155208 0.19496855345912 29.1 29 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.447653488166194 0.670210047194438 0.839941978155208 0.19496855345912 29.1 29 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.478087100193653 0.689977630401184 0.829507916314771 0.192546583850932 29.1 29 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.493257724505671 0.709024869281439 0.82438749707826 0.191358024691358 29.1 29 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.501542895474618 0.720177134470617 0.823605345752759 0.191176470588235 29.1 29 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.512704567642595 0.729578599755412 0.819143778332646 0.190140845070423 29.1 29 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.564555840699197 0.77910150061567 0.80776678141136 0.1875 29.1 29 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.554730096799615 0.77910150061567 0.805250373992633 0.186915887850467 29.1 29 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.574337328379711 0.789644462110462 0.79779435201122 0.185185185185185 29.1 29 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.604731682706594 0.819555413801412 0.786147719135143 0.182481751824818 29.1 29 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.604731682706594 0.819555413801412 0.786147719135143 0.182481751824818 29.1 29 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.629741062447373 0.851826551200201 0.778235522736106 0.180645161290323 29.1 29 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.650610717425331 0.857239861940969 0.769301696582247 0.178571428571429 29.1 29 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.765617983314848 0.970656336179876 0.755025994996185 0.175257731958763 29.1 29 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.661102736018051 0.870258273222652 0.742774051872515 0.172413793103448 29.1 29 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.668460178512136 0.879130160834353 0.738529628718957 0.171428571428571 29.1 29 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.682628648818502 0.896107534380746 0.733291829933717 0.170212765957447 29.1 29 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.682628648818502 0.896107534380746 0.733291829933717 0.170212765957447 29.1 29 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.691638586055368 0.901283615345044 0.718014916810098 0.166666666666667 29.1 29 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.691638586055368 0.901283615345044 0.718014916810098 0.166666666666667 29.1 29 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.752627918274376 0.957095199020945 0.709567682494685 0.164705882352941 29.1 29 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.752627918274376 0.957095199020945 0.709567682494685 0.164705882352941 29.1 29 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.74859379622575 0.954540611778985 0.70892612039478 0.164556962025316 29.1 29 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.73246634805592 0.937206687797848 0.704960100140823 0.163636363636364 29.1 29 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.722249828409429 0.925077863030259 0.698609108247662 0.162162162162162 29.1 29 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.924704391520559 1 0.676985492992378 0.157142857142857 29.1 29 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.771593685486375 0.97252242200807 0.652740833463725 0.151515151515152 29.1 29 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.810695627615468 1 0.630452122077159 0.146341463414634 29.1 29 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.99999333131826 1 0.611307410281645 0.141897565071369 29.1 29 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.888302931143705 1 0.561924717503555 0.130434782608696 29.1 29 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999991388274 1 0.545327784919061 0.126582278481013 29.1 29 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.91074328189407 1 0.538511187607573 0.125 29.1 29 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.950506555941367 1 0.487708245380444 0.113207547169811 29.1 29 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.998709321139264 1 0.465077843842904 0.107954545454545 29.1 29 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.966798122654581 1 0.43960096947557 0.102040816326531 29.1 29 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999811210690921 1 0.416911887180057 0.0967741935483871 29.1 29 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.998661721317166 1 0.303386584567647 0.0704225352112676 29.1 29 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999997088071055 1 0.199448588002805 0.0462962962962963 29.1 29 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0764338459830104 0.017741935483871 29.1 29 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 3.12527398847508e-09 1.29594571240512e-07 2.6877921513208 1 3.1 3 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 7.90429002646187e-06 7.21013122285592e-05 2.6877921513208 1 3.1 3 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 7.90429002646187e-06 7.21013122285592e-05 2.6877921513208 1 3.1 3 1 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 2.91678708015973e-05 0.000221956578345844 2.6877921513208 1 3.1 3 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 2.91678708015973e-05 0.000221956578345844 2.6877921513208 1 3.1 3 1 SCAVENGING BY CLASS B RECEPTORS%REACTOME%REACT_196592.2 SCAVENGING BY CLASS B RECEPTORS 0.000397086497019412 0.00207740472521552 2.6877921513208 1 3.1 3 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.000397086497019412 0.00207740472521552 2.6877921513208 1 3.1 3 1 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.000397086497019412 0.00207740472521552 2.6877921513208 1 3.1 3 1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.00146495289236474 0.00627899989709346 2.6877921513208 1 3.1 3 1 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.00146495289236474 0.00627899989709346 2.6877921513208 1 3.1 3 1 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604677 HISTIDINE CATABOLISM 0.00146495289236474 0.00627899989709346 2.6877921513208 1 3.1 3 1 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.00146495289236474 0.00627899989709346 2.6877921513208 1 3.1 3 1 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.00146495289236474 0.00627899989709346 2.6877921513208 1 3.1 3 1 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.00146495289236474 0.00627899989709346 2.6877921513208 1 3.1 3 1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00146495289236474 0.00627899989709346 2.6877921513208 1 3.1 3 1 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.00146495289236474 0.00627899989709346 2.6877921513208 1 3.1 3 1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 1.77569043165371e-05 0.000147766519546388 2.44344741029163 0.909090909090909 3.1 3 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 1.77569043165371e-05 0.000147766519546388 2.44344741029163 0.909090909090909 3.1 3 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 1.77569043165371e-05 0.000147766519546388 2.44344741029163 0.909090909090909 3.1 3 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 5.97663610315752e-05 0.000410857641294355 2.41901293618872 0.9 3.1 3 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 5.97663610315752e-05 0.000410857641294355 2.41901293618872 0.9 3.1 3 1 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.00019927651700268 0.00114342936973715 2.38914857895182 0.888888888888889 3.1 3 1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.00019927651700268 0.00114342936973715 2.38914857895182 0.888888888888889 3.1 3 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 2.36699293070012e-07 3.66112058737638e-06 2.37158130998894 0.882352941176471 3.1 3 1 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 48%5605118 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS 0.000656822880000458 0.00313452958120261 2.3518181324057 0.875 3.1 3 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.000656822880000458 0.00313452958120261 2.3518181324057 0.875 3.1 3 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 2.5068531440385e-06 2.83115239997364e-05 2.32941986447802 0.866666666666667 3.1 3 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00213385699742715 0.00866606602089779 2.30382184398925 0.857142857142857 3.1 3 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00213385699742715 0.00866606602089779 2.30382184398925 0.857142857142857 3.1 3 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00213385699742715 0.00866606602089779 2.30382184398925 0.857142857142857 3.1 3 1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%REACT_215211.1 TERMINAL PATHWAY OF COMPLEMENT 0.00213385699742715 0.00866606602089779 2.30382184398925 0.857142857142857 3.1 3 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00213385699742715 0.00866606602089779 2.30382184398925 0.857142857142857 3.1 3 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 4.72132272797814e-09 1.3411873680047e-07 2.25774540710947 0.84 3.1 3 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 1.06054653293837e-06 1.31231105771418e-05 2.23982679276733 0.833333333333333 3.1 3 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 8.03691176170887e-05 0.000534417076491202 2.23982679276733 0.833333333333333 3.1 3 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 8.03691176170887e-05 0.000534417076491202 2.23982679276733 0.833333333333333 3.1 3 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00680428486909138 0.0235583877584356 2.23982679276733 0.833333333333333 3.1 3 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%REACT_226440.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL 0.00680428486909138 0.0235583877584356 2.23982679276733 0.833333333333333 3.1 3 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00680428486909138 0.0235583877584356 2.23982679276733 0.833333333333333 3.1 3 1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00680428486909138 0.0235583877584356 2.23982679276733 0.833333333333333 3.1 3 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.000248808916249248 0.00139391766859323 2.19910266926247 0.818181818181818 3.1 3 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 1.00184991646106e-05 8.80020019212403e-05 2.18383112294815 0.8125 3.1 3 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 1.00184991646106e-05 8.80020019212403e-05 2.18383112294815 0.8125 3.1 3 1 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 5.30772224217065e-13 4.1960493058938e-11 2.17583174154541 0.80952380952381 3.1 3 1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 3.02321611783893e-05 0.000227620980724063 2.15023372105664 0.8 3.1 3 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0007573171408871 0.00346515206264419 2.15023372105664 0.8 3.1 3 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.0007573171408871 0.00346515206264419 2.15023372105664 0.8 3.1 3 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0007573171408871 0.00346515206264419 2.15023372105664 0.8 3.1 3 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 9.27393424370528e-10 4.25703497702988e-08 2.11765442225275 0.787878787878788 3.1 3 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 6.08979554463398e-08 1.00764872790862e-06 2.09050500658284 0.777777777777778 3.1 3 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 1.10390094167833e-05 9.63712294483601e-05 2.09050500658284 0.777777777777778 3.1 3 1 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 7.85453342585445e-09 1.57422550211139e-07 2.08087134295804 0.774193548387097 3.1 3 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 1.38350612422381e-06 1.66841458878854e-05 2.07693029874789 0.772727272727273 3.1 3 1 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.000262954839418167 0.00146739112349824 2.06753242409292 0.769230769230769 3.1 3 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 2.25657891873246e-08 4.28148240180838e-07 2.06064064934594 0.766666666666667 3.1 3 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000754128312145723 0.00346515206264419 2.0158441134906 0.75 3.1 3 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000754128312145723 0.00346515206264419 2.0158441134906 0.75 3.1 3 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.000754128312145723 0.00346515206264419 2.0158441134906 0.75 3.1 3 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.000754128312145723 0.00346515206264419 2.0158441134906 0.75 3.1 3 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.000754128312145723 0.00346515206264419 2.0158441134906 0.75 3.1 3 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.00656495934970723 0.0229531625420968 2.0158441134906 0.75 3.1 3 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00656495934970723 0.0229531625420968 2.0158441134906 0.75 3.1 3 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00656495934970723 0.0229531625420968 2.0158441134906 0.75 3.1 3 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00656495934970723 0.0229531625420968 2.0158441134906 0.75 3.1 3 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 6.48606495015516e-08 1.06088165793917e-06 1.99416837033478 0.741935483870968 3.1 3 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 5.19081255695746e-11 3.07771927856269e-09 1.98662898141102 0.739130434782609 3.1 3 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 3.95456574730897e-06 4.19951273016468e-05 1.98662898141102 0.739130434782609 3.1 3 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 3.14099533990958e-05 0.000234012375324154 1.98047842728901 0.736842105263158 3.1 3 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.00211333907325471 0.00866606602089779 1.95475792823331 0.727272727272727 3.1 3 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00211333907325471 0.00866606602089779 1.95475792823331 0.727272727272727 3.1 3 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 8.62292148015302e-05 0.000562863177351273 1.94118322039835 0.722222222222222 3.1 3 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 3.77359016913843e-06 4.03745775239398e-05 1.93521034895097 0.72 3.1 3 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.018480354548252 0.0537782096567742 1.91985153665771 0.714285714285714 3.1 3 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 6.61407743626363e-16 9.41183219180314e-14 1.90527038574639 0.708860759493671 3.1 3 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.000232348274356954 0.00130684424667963 1.89726504799115 0.705882352941177 3.1 3 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000232348274356954 0.00130684424667963 1.89726504799115 0.705882352941177 3.1 3 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 9.22656905914285e-10 4.25703497702988e-08 1.88717321262949 0.702127659574468 3.1 3 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0057603771729057 0.0206473972721532 1.88145450592456 0.7 3.1 3 1 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.0057603771729057 0.0206473972721532 1.88145450592456 0.7 3.1 3 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.0057603771729057 0.0206473972721532 1.88145450592456 0.7 3.1 3 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0057603771729057 0.0206473972721532 1.88145450592456 0.7 3.1 3 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00185926862578273 0.00775876614219597 1.86077918168363 0.692307692307692 3.1 3 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00185926862578273 0.00775876614219597 1.86077918168363 0.692307692307692 3.1 3 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00185926862578273 0.00775876614219597 1.86077918168363 0.692307692307692 3.1 3 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.17506088915101e-32 1.03170388175396e-29 1.85516088705294 0.690217391304348 3.1 3 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.000612982269005661 0.00295686023320358 1.84785710403305 0.6875 3.1 3 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000612982269005661 0.00295686023320358 1.84785710403305 0.6875 3.1 3 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000612982269005661 0.00295686023320358 1.84785710403305 0.6875 3.1 3 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 3.76716117301604e-07 5.70284079702322e-06 1.8430574751914 0.685714285714286 3.1 3 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 3.53539821912268e-08 6.21095267384144e-07 1.79186143421386 0.666666666666667 3.1 3 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 2.04461390623238e-05 0.000167211815434981 1.79186143421386 0.666666666666667 3.1 3 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000176416312023493 0.00102465474289563 1.79186143421386 0.666666666666667 3.1 3 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.00157861993629829 0.00670560050552975 1.79186143421386 0.666666666666667 3.1 3 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00483176059547269 0.0180461819615686 1.79186143421386 0.666666666666667 3.1 3 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00483176059547269 0.0180461819615686 1.79186143421386 0.666666666666667 3.1 3 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 8.38485338869505e-07 1.0959846737485e-05 1.79186143421386 0.666666666666667 3.1 3 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000524586393467804 0.00261925065931468 1.79186143421386 0.666666666666667 3.1 3 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000524586393467804 0.00261925065931468 1.79186143421386 0.666666666666667 3.1 3 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0151784077481363 0.0454956441506513 1.79186143421386 0.666666666666667 3.1 3 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0151784077481363 0.0454956441506513 1.79186143421386 0.666666666666667 3.1 3 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0151784077481363 0.0454956441506513 1.79186143421386 0.666666666666667 3.1 3 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0151784077481363 0.0454956441506513 1.79186143421386 0.666666666666667 3.1 3 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0151784077481363 0.0454956441506513 1.79186143421386 0.666666666666667 3.1 3 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0151784077481363 0.0454956441506513 1.79186143421386 0.666666666666667 3.1 3 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 1.13825020502065e-28 4.04932510436095e-26 1.77741093877666 0.661290322580645 3.1 3 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 6.01804401954285e-06 5.86553194507498e-05 1.76386359930427 0.65625 3.1 3 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 5.08781130883562e-05 0.000356648053816409 1.75740256047898 0.653846153846154 3.1 3 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 5.08781130883562e-05 0.000356648053816409 1.75740256047898 0.653846153846154 3.1 3 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.63271880543321e-08 4.80302417965572e-07 1.75529283351562 0.653061224489796 3.1 3 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 2.63271880543321e-08 4.80302417965572e-07 1.75529283351562 0.653061224489796 3.1 3 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000149099604722584 0.000914520420345851 1.75290792477443 0.652173913043478 3.1 3 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000149099604722584 0.000914520420345851 1.75290792477443 0.652173913043478 3.1 3 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000440047643708758 0.00224440070608445 1.74706489835852 0.65 3.1 3 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000440047643708758 0.00224440070608445 1.74706489835852 0.65 3.1 3 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000440047643708758 0.00224440070608445 1.74706489835852 0.65 3.1 3 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.47354646091556e-18 6.17857076735355e-16 1.73405945246503 0.645161290322581 3.1 3 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 1.47312805677105e-05 0.000127046134835467 1.73405945246503 0.645161290322581 3.1 3 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 9.76964170275496e-18 1.54468890478003e-15 1.73262634547952 0.644628099173554 3.1 3 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00395394149307926 0.0150038899857381 1.72786638299194 0.642857142857143 3.1 3 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00395394149307926 0.0150038899857381 1.72786638299194 0.642857142857143 3.1 3 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00395394149307926 0.0150038899857381 1.72786638299194 0.642857142857143 3.1 3 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 4.28243024375407e-06 4.32191364316457e-05 1.71720054112162 0.638888888888889 3.1 3 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000363922084632398 0.00193955478064383 1.71041318720414 0.636363636363636 3.1 3 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.012142693847295 0.0377271907089535 1.71041318720414 0.636363636363636 3.1 3 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.012142693847295 0.0377271907089535 1.71041318720414 0.636363636363636 3.1 3 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.012142693847295 0.0377271907089535 1.71041318720414 0.636363636363636 3.1 3 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.012142693847295 0.0377271907089535 1.71041318720414 0.636363636363636 3.1 3 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.012142693847295 0.0377271907089535 1.71041318720414 0.636363636363636 3.1 3 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00107244144311523 0.00478396292649835 1.69755293767629 0.631578947368421 3.1 3 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.14574850280189e-25 5.08900019914514e-23 1.69386901203029 0.630208333333333 3.1 3 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 6.87335545605941e-15 8.15065401164379e-13 1.69231357675754 0.62962962962963 3.1 3 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000102612468932612 0.00065478718964622 1.69231357675754 0.62962962962963 3.1 3 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.000297840949597196 0.00163010642798773 1.6798700945755 0.625 3.1 3 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00318801604845267 0.0123275729264895 1.6798700945755 0.625 3.1 3 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00318801604845267 0.0123275729264895 1.6798700945755 0.625 3.1 3 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0383393465458265 0.0958820564757665 1.6798700945755 0.625 3.1 3 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0383393465458265 0.0958820564757665 1.6798700945755 0.625 3.1 3 1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%REACT_212869.1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 0.0383393465458265 0.0958820564757665 1.6798700945755 0.625 3.1 3 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0383393465458265 0.0958820564757665 1.6798700945755 0.625 3.1 3 1 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.0383393465458265 0.0958820564757665 1.6798700945755 0.625 3.1 3 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0383393465458265 0.0958820564757665 1.6798700945755 0.625 3.1 3 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0383393465458265 0.0958820564757665 1.6798700945755 0.625 3.1 3 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 3.27963099914088e-12 2.33345745588873e-10 1.67240400526627 0.622222222222222 3.1 3 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.40125683826469e-05 0.000553471688928271 1.66828478357842 0.620689655172414 3.1 3 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.000868448557697317 0.00394719252045516 1.66387133177002 0.619047619047619 3.1 3 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 2.39590601913118e-05 0.000190467836046015 1.66010691699226 0.617647058823529 3.1 3 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00958774774697661 0.0305220694495475 1.65402593927434 0.615384615384615 3.1 3 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00958774774697661 0.0305220694495475 1.65402593927434 0.615384615384615 3.1 3 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00958774774697661 0.0305220694495475 1.65402593927434 0.615384615384615 3.1 3 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.00958774774697661 0.0305220694495475 1.65402593927434 0.615384615384615 3.1 3 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00958774774697661 0.0305220694495475 1.65402593927434 0.615384615384615 3.1 3 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00958774774697661 0.0305220694495475 1.65402593927434 0.615384615384615 3.1 3 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00958774774697661 0.0305220694495475 1.65402593927434 0.615384615384615 3.1 3 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00958774774697661 0.0305220694495475 1.65402593927434 0.615384615384615 3.1 3 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 6.83474255072614e-05 0.000465351131563794 1.64735647984178 0.612903225806452 3.1 3 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00254630747676619 0.0099818058937694 1.64253964802938 0.611111111111111 3.1 3 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 5.61747799501067e-06 5.51287668062081e-05 1.63889765324439 0.609756097560976 3.1 3 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.28035477744486e-09 1.29594571240512e-07 1.63604739645614 0.608695652173913 3.1 3 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000698090386714332 0.00328934642481621 1.63604739645614 0.608695652173913 3.1 3 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000558109344635844 0.00276721114082511 1.61267529079248 0.6 3.1 3 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000558109344635844 0.00276721114082511 1.61267529079248 0.6 3.1 3 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00751692382825074 0.0249920154383196 1.61267529079248 0.6 3.1 3 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00751692382825074 0.0249920154383196 1.61267529079248 0.6 3.1 3 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00202103214222494 0.00838463189033845 1.61267529079248 0.6 3.1 3 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0293054536109822 0.0760979205993207 1.61267529079248 0.6 3.1 3 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.40904715560924e-09 1.3411873680047e-07 1.60520920148325 0.597222222222222 3.1 3 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000444376344143239 0.00225838406327082 1.59276571930121 0.592592592592593 3.1 3 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.7804025474021e-58 1.26675641247659e-55 1.58631515760965 0.590192644483363 3.1 3 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 2.86826352974541e-05 0.000220623729882579 1.58510819180457 0.58974358974359 3.1 3 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00586973717596368 0.0209865226165737 1.58105420665929 0.588235294117647 3.1 3 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00125843959867832 0.00556136505875544 1.56787875493713 0.583333333333333 3.1 3 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0223780003998462 0.0605397235151732 1.56787875493713 0.583333333333333 3.1 3 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0223780003998462 0.0605397235151732 1.56787875493713 0.583333333333333 3.1 3 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.90542014880085e-07 4.44560523843399e-06 1.56065350721853 0.580645161290323 3.1 3 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00457287327303628 0.0172148112897636 1.55609019286993 0.578947368421053 3.1 3 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000989372628306067 0.00444125315482502 1.55064931806969 0.576923076923077 3.1 3 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 5.01839508694629e-05 0.000356648053816409 1.54548048700946 0.575 3.1 3 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 5.01839508694629e-05 0.000356648053816409 1.54548048700946 0.575 3.1 3 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00355781025492842 0.0136831459263869 1.53588122932617 0.571428571428571 3.1 3 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0170994894188397 0.0499642165154187 1.53588122932617 0.571428571428571 3.1 3 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.0170994894188397 0.0499642165154187 1.53588122932617 0.571428571428571 3.1 3 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.27460997302081e-06 6.85547681563484e-05 1.52835239977065 0.568627450980392 3.1 3 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.27460997302081e-06 6.85547681563484e-05 1.52835239977065 0.568627450980392 3.1 3 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 4.21404673831032e-09 1.29594571240512e-07 1.52715463143227 0.568181818181818 3.1 3 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00276606324049087 0.0107543934186298 1.51918686813784 0.565217391304348 3.1 3 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00214976901291421 0.00866606602089779 1.50516360473965 0.56 3.1 3 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00214976901291421 0.00866606602089779 1.50516360473965 0.56 3.1 3 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00214976901291421 0.00866606602089779 1.50516360473965 0.56 3.1 3 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0016706179835096 0.00705427118852865 1.49321786184489 0.555555555555556 3.1 3 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000292257836434124 0.00160572548743536 1.49321786184489 0.555555555555556 3.1 3 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0100240242999606 0.0316981923974309 1.49321786184489 0.555555555555556 3.1 3 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0100240242999606 0.0316981923974309 1.49321786184489 0.555555555555556 3.1 3 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0100240242999606 0.0316981923974309 1.49321786184489 0.555555555555556 3.1 3 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0672905200429393 0.151644879193982 1.49321786184489 0.555555555555556 3.1 3 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0672905200429393 0.151644879193982 1.49321786184489 0.555555555555556 3.1 3 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0672905200429393 0.151644879193982 1.49321786184489 0.555555555555556 3.1 3 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0672905200429393 0.151644879193982 1.49321786184489 0.555555555555556 3.1 3 1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0672905200429393 0.151644879193982 1.49321786184489 0.555555555555556 3.1 3 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0672905200429393 0.151644879193982 1.49321786184489 0.555555555555556 3.1 3 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 3.23983294210972e-05 0.00023887472935866 1.48102832827881 0.551020408163265 3.1 3 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 4.68715593429815e-06 4.69705837641286e-05 1.47828568322644 0.55 3.1 3 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.00769179021069458 0.0253366145134685 1.47828568322644 0.55 3.1 3 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00769179021069458 0.0253366145134685 1.47828568322644 0.55 3.1 3 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00769179021069458 0.0253366145134685 1.47828568322644 0.55 3.1 3 1 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.00769179021069458 0.0253366145134685 1.47828568322644 0.55 3.1 3 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 1.51700659403663e-08 2.91716268015423e-07 1.47395053459528 0.548387096774194 3.1 3 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 6.16201590035572e-12 4.17549934581247e-10 1.46958419784446 0.546762589928058 3.1 3 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00591053173829321 0.0210794151969705 1.46606844617498 0.545454545454545 3.1 3 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0499007653274069 0.119745006848061 1.46606844617498 0.545454545454545 3.1 3 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 8.55074660481027e-05 0.000560724074591936 1.46075660397869 0.543478260869565 3.1 3 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00061013074727992 0.00295686023320358 1.45908716785986 0.542857142857143 3.1 3 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00061013074727992 0.00295686023320358 1.45908716785986 0.542857142857143 3.1 3 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 6.68593173151376e-05 0.000457407733362696 1.45588741529876 0.541666666666667 3.1 3 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00454780027172388 0.0171658349778862 1.45588741529876 0.541666666666667 3.1 3 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 7.55814459196664e-06 7.02956846690753e-05 1.45405149169814 0.540983606557377 3.1 3 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.000474607027500056 0.00240260275290573 1.45286062233557 0.540540540540541 3.1 3 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 7.40448418108208e-09 1.50522585566854e-07 1.44727269686504 0.538461538461538 3.1 3 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00350356479495705 0.0135110371361081 1.44727269686504 0.538461538461538 3.1 3 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0372999618281941 0.0951215872428677 1.44727269686504 0.538461538461538 3.1 3 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0372999618281941 0.0951215872428677 1.44727269686504 0.538461538461538 3.1 3 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0372999618281941 0.0951215872428677 1.44727269686504 0.538461538461538 3.1 3 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0372999618281941 0.0951215872428677 1.44727269686504 0.538461538461538 3.1 3 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 3.64516926037236e-06 3.92960292235596e-05 1.44418682757535 0.537313432835821 3.1 3 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.19673833682979e-05 0.000236924929859833 1.44344393311672 0.537037037037037 3.1 3 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.49997679456038e-05 0.000197637054369968 1.43988865249328 0.535714285714286 3.1 3 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 2.24128450359841e-06 2.55147827889643e-05 1.43853664436888 0.535211267605634 3.1 3 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.53029355674755e-111 6.44660773125176e-108 1.43499296910413 0.533892834086507 3.1 3 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.000174298100369721 0.0010165008066644 1.43348914737109 0.533333333333333 3.1 3 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0280509929509414 0.074194354961319 1.43348914737109 0.533333333333333 3.1 3 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0280509929509414 0.074194354961319 1.43348914737109 0.533333333333333 3.1 3 1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.0280509929509414 0.074194354961319 1.43348914737109 0.533333333333333 3.1 3 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0280509929509414 0.074194354961319 1.43348914737109 0.533333333333333 3.1 3 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 8.47212326861104e-07 1.0959846737485e-05 1.42895278930979 0.531645569620253 3.1 3 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 8.47212326861104e-07 1.0959846737485e-05 1.42895278930979 0.531645569620253 3.1 3 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 4.0844846156155e-07 5.75467485942659e-06 1.42294878599336 0.529411764705882 3.1 3 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 4.0844846156155e-07 5.75467485942659e-06 1.42294878599336 0.529411764705882 3.1 3 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 4.0844846156155e-07 5.75467485942659e-06 1.42294878599336 0.529411764705882 3.1 3 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0211972032818791 0.0575641608208281 1.42294878599336 0.529411764705882 3.1 3 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0211972032818791 0.0575641608208281 1.42294878599336 0.529411764705882 3.1 3 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0211972032818791 0.0575641608208281 1.42294878599336 0.529411764705882 3.1 3 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0211972032818791 0.0575641608208281 1.42294878599336 0.529411764705882 3.1 3 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0211972032818791 0.0575641608208281 1.42294878599336 0.529411764705882 3.1 3 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000965400471166398 0.0043611583189517 1.41855696875264 0.527777777777778 3.1 3 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 5.01566404349499e-05 0.000356648053816409 1.41719949796915 0.527272727272727 3.1 3 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 5.01566404349499e-05 0.000356648053816409 1.41719949796915 0.527272727272727 3.1 3 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000747905704927503 0.00346515206264419 1.41462744806358 0.526315789473684 3.1 3 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0160808587743209 0.0475739335464838 1.41462744806358 0.526315789473684 3.1 3 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0160808587743209 0.0475739335464838 1.41462744806358 0.526315789473684 3.1 3 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.05303316758301e-05 0.000228656115656348 1.41222977442279 0.525423728813559 3.1 3 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00057981502431076 0.00286484992914657 1.41109087944342 0.525 3.1 3 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 2.38278722868269e-05 0.000190467836046015 1.40998932528304 0.524590163934426 3.1 3 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.38278722868269e-05 0.000190467836046015 1.40998932528304 0.524590163934426 3.1 3 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0122391681620373 0.0378109998593532 1.40789112688232 0.523809523809524 3.1 3 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0122391681620373 0.0378109998593532 1.40789112688232 0.523809523809524 3.1 3 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 6.32160340591776e-07 8.48645438360469e-06 1.40640286987716 0.523255813953488 3.1 3 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.000349139012905731 0.00187481062401832 1.40498226091769 0.522727272727273 3.1 3 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 8.85974736393077e-06 7.92919528231037e-05 1.40232633981955 0.521739130434783 3.1 3 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 8.85974736393077e-06 7.92919528231037e-05 1.40232633981955 0.521739130434783 3.1 3 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00934086100862304 0.0303471351946817 1.40232633981955 0.521739130434783 3.1 3 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.00934086100862304 0.0303471351946817 1.40232633981955 0.521739130434783 3.1 3 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 6.92176548998918e-06 6.65518398125311e-05 1.40068041688549 0.52112676056338 3.1 3 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 4.0397458178127e-09 1.29594571240512e-07 1.39852599743521 0.520325203252033 3.1 3 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.2270514799187e-06 4.29649589708879e-05 1.39765191868681 0.52 3.1 3 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.2270514799187e-06 4.29649589708879e-05 1.39765191868681 0.52 3.1 3 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.2270514799187e-06 4.29649589708879e-05 1.39765191868681 0.52 3.1 3 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.2270514799187e-06 4.29649589708879e-05 1.39765191868681 0.52 3.1 3 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.2270514799187e-06 4.29649589708879e-05 1.39765191868681 0.52 3.1 3 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 7.02097120122658e-08 1.1353229567438e-06 1.39558438626272 0.519230769230769 3.1 3 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.01974147124185e-06 2.36274231814458e-05 1.39367000438856 0.518518518518518 3.1 3 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 9.91432787829203e-05 0.000635499485171602 1.39367000438856 0.518518518518518 3.1 3 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.57946849589834e-06 1.88872577282633e-05 1.39247063261198 0.518072289156627 3.1 3 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 7.7176984960544e-05 0.000518032309428557 1.39189236407684 0.517857142857143 3.1 3 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00420626608728546 0.0159189272399128 1.39023731964869 0.517241379310345 3.1 3 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 4.62850750719633e-07 6.39453027450523e-06 1.38724756197202 0.516129032258065 3.1 3 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 2.84400281265218e-05 0.000219946521869786 1.38589282802479 0.515625 3.1 3 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00249170136149922 0.0097947266226889 1.38462019916526 0.515151515151515 3.1 3 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.72965558081855e-05 0.000146505945922904 1.38342243082688 0.514705882352941 3.1 3 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.3494329942086e-05 0.00011708799699749 1.38229310639355 0.514285714285714 3.1 3 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.00148346021725865 0.00633923089837557 1.38021759121879 0.513513513513513 3.1 3 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 6.41744369251288e-06 6.21226011867063e-05 1.37926176186199 0.513157894736842 3.1 3 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 5.01140929032769e-06 4.98687791617923e-05 1.37835494939528 0.512820512820513 3.1 3 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.05786676748339e-06 3.42625544104635e-05 1.37667402872529 0.51219512195122 3.1 3 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.14097404316764e-06 1.39966039950652e-05 1.3737604328973 0.511111111111111 3.1 3 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000412420105710005 0.00214972091730893 1.37248960918509 0.51063829787234 3.1 3 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000192941166766641 0.00111607837523956 1.36925260538984 0.509433962264151 3.1 3 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000149944237069705 0.000915753859872061 1.36833054976331 0.509090909090909 3.1 3 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 9.06897500844685e-05 0.000588864854892112 1.36667397524786 0.508474576271186 3.1 3 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 5.49444813709065e-05 0.000381395107272195 1.36522775940104 0.507936507936508 3.1 3 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 5.49444813709065e-05 0.000381395107272195 1.36522775940104 0.507936507936508 3.1 3 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 7.50197011075217e-06 7.02322596552653e-05 1.36090741839028 0.506329113924051 3.1 3 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.57073980826653e-06 3.87875018867425e-05 1.35970661772699 0.505882352941176 3.1 3 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 3.57073980826653e-06 3.87875018867425e-05 1.35970661772699 0.505882352941176 3.1 3 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.57073980826653e-06 3.87875018867425e-05 1.35970661772699 0.505882352941176 3.1 3 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.28129764094718e-08 7.34010426875643e-07 1.35500265479809 0.504132231404959 3.1 3 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.28129764094718e-08 7.34010426875643e-07 1.35500265479809 0.504132231404959 3.1 3 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.35212527650204e-08 5.962592835578e-07 1.35482206001536 0.504065040650406 3.1 3 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 8.14489346152909e-05 0.000539078297477018 1.3438960756604 0.5 3.1 3 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000173071336892211 0.00101494035108807 1.3438960756604 0.5 3.1 3 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000173071336892211 0.00101494035108807 1.3438960756604 0.5 3.1 3 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000476130693126786 0.00240260275290573 1.3438960756604 0.5 3.1 3 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00373631830917918 0.0142924219192526 1.3438960756604 0.5 3.1 3 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00373631830917918 0.0142924219192526 1.3438960756604 0.5 3.1 3 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00632628157253053 0.0223937778052511 1.3438960756604 0.5 3.1 3 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0107877701425783 0.0338874104037285 1.3438960756604 0.5 3.1 3 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.0141339217455222 0.0431199793492464 1.3438960756604 0.5 3.1 3 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.043019323499606 0.104643585196478 1.3438960756604 0.5 3.1 3 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.043019323499606 0.104643585196478 1.3438960756604 0.5 3.1 3 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.043019323499606 0.104643585196478 1.3438960756604 0.5 3.1 3 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.043019323499606 0.104643585196478 1.3438960756604 0.5 3.1 3 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.043019323499606 0.104643585196478 1.3438960756604 0.5 3.1 3 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.043019323499606 0.104643585196478 1.3438960756604 0.5 3.1 3 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.043019323499606 0.104643585196478 1.3438960756604 0.5 3.1 3 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0774235302549675 0.164684130871179 1.3438960756604 0.5 3.1 3 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.0774235302549675 0.164684130871179 1.3438960756604 0.5 3.1 3 1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.0774235302549675 0.164684130871179 1.3438960756604 0.5 3.1 3 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0774235302549675 0.164684130871179 1.3438960756604 0.5 3.1 3 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0774235302549675 0.164684130871179 1.3438960756604 0.5 3.1 3 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0774235302549675 0.164684130871179 1.3438960756604 0.5 3.1 3 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000792693868757102 0.00361539543346588 1.3438960756604 0.5 3.1 3 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00825285206174056 0.0270594665526655 1.3438960756604 0.5 3.1 3 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0575004342375482 0.136144954941815 1.3438960756604 0.5 3.1 3 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0575004342375482 0.136144954941815 1.3438960756604 0.5 3.1 3 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0575004342375482 0.136144954941815 1.3438960756604 0.5 3.1 3 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0575004342375482 0.136144954941815 1.3438960756604 0.5 3.1 3 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0575004342375482 0.136144954941815 1.3438960756604 0.5 3.1 3 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.105275586474896 0.207776920324241 1.3438960756604 0.5 3.1 3 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.105275586474896 0.207776920324241 1.3438960756604 0.5 3.1 3 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.105275586474896 0.207776920324241 1.3438960756604 0.5 3.1 3 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.105275586474896 0.207776920324241 1.3438960756604 0.5 3.1 3 1 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.105275586474896 0.207776920324241 1.3438960756604 0.5 3.1 3 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.105275586474896 0.207776920324241 1.3438960756604 0.5 3.1 3 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.105275586474896 0.207776920324241 1.3438960756604 0.5 3.1 3 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.71056435400408e-08 4.88244693132633e-07 1.33379159388852 0.496240601503759 3.1 3 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 9.86588985706399e-06 8.77447579162629e-05 1.3280855335938 0.494117647058824 3.1 3 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.61956732930979e-05 0.00013800265326993 1.32730476608434 0.493827160493827 3.1 3 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.61956732930979e-05 0.00013800265326993 1.32730476608434 0.493827160493827 3.1 3 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.07581839989264e-05 0.000168793690459841 1.32688473293052 0.493670886075949 3.1 3 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 3.41285691703897e-05 0.000250334814069405 1.32597746131826 0.493333333333333 3.1 3 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 5.01876255777523e-08 8.44216375821997e-07 1.32353401390797 0.492424242424242 3.1 3 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 7.41756026354869e-07 9.86466192058858e-06 1.31946160155748 0.490909090909091 3.1 3 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00041864834322814 0.00215846591454219 1.31946160155748 0.490909090909091 3.1 3 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00041864834322814 0.00215846591454219 1.31946160155748 0.490909090909091 3.1 3 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00041864834322814 0.00215846591454219 1.31946160155748 0.490909090909091 3.1 3 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.00115712289167724 0.00514558085892722 1.31530254213571 0.48936170212766 3.1 3 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.32278144819944e-10 1.18047071456707e-08 1.30189932329601 0.484375 3.1 3 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.000219896121449833 0.00124666207499248 1.30189932329601 0.484375 3.1 3 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000363230506961862 0.00193955478064383 1.29909953980505 0.483333333333333 3.1 3 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.12356647909765e-08 2.22060430521661e-07 1.29349997282313 0.48125 3.1 3 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.43200795941941e-08 2.79143469349839e-07 1.29286204747076 0.481012658227848 3.1 3 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.7217918705987e-11 3.82604393274478e-09 1.29270003468286 0.480952380952381 3.1 3 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0205846180009879 0.0575479595587539 1.29014023263398 0.48 3.1 3 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.0205846180009879 0.0575479595587539 1.29014023263398 0.48 3.1 3 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.0270258361981767 0.0720182863483247 1.28546581150125 0.478260869565217 3.1 3 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 2.25072957203737e-05 0.000181976601193703 1.2841673611866 0.477777777777778 3.1 3 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.00276131383116648 0.0107543934186298 1.28280989040311 0.477272727272727 3.1 3 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.00276131383116648 0.0107543934186298 1.28280989040311 0.477272727272727 3.1 3 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.48776705470212e-06 3.87741603034463e-05 1.28224946668515 0.477064220183486 3.1 3 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.0355887993160473 0.0914131072684752 1.27990102443847 0.476190476190476 3.1 3 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0355887993160473 0.0914131072684752 1.27990102443847 0.476190476190476 3.1 3 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0355887993160473 0.0914131072684752 1.27990102443847 0.476190476190476 3.1 3 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00461762320641924 0.0173374085032575 1.27670127187738 0.475 3.1 3 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.2733417020664e-07 3.55490685938515e-06 1.27621785602282 0.474820143884892 3.1 3 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.000660828442980171 0.00313452958120261 1.275562376898 0.474576271186441 3.1 3 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.000660828442980171 0.00313452958120261 1.275562376898 0.474576271186441 3.1 3 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 1.93186940677785e-05 0.000159828498014237 1.27316470325722 0.473684210526316 3.1 3 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00597982058789952 0.0212201613381073 1.27316470325722 0.473684210526316 3.1 3 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00597982058789952 0.0212201613381073 1.27316470325722 0.473684210526316 3.1 3 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.25547547419329e-10 6.87131384529636e-09 1.27059265335165 0.472727272727273 3.1 3 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 9.73063171745418e-07 1.23631151195869e-05 1.26982306361612 0.47244094488189 3.1 3 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000207442759400884 0.00118076418650983 1.26923518256815 0.472222222222222 3.1 3 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 4.02959095538653e-05 0.000292556527016073 1.26839629612891 0.471910112359551 3.1 3 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.37028826202977e-10 7.221926655068e-09 1.26555235824522 0.47085201793722 3.1 3 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0624167636931412 0.145798025035384 1.26484336532743 0.470588235294118 3.1 3 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0624167636931412 0.145798025035384 1.26484336532743 0.470588235294118 3.1 3 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0624167636931412 0.145798025035384 1.26484336532743 0.470588235294118 3.1 3 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0624167636931412 0.145798025035384 1.26484336532743 0.470588235294118 3.1 3 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0624167636931412 0.145798025035384 1.26484336532743 0.470588235294118 3.1 3 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0624167636931412 0.145798025035384 1.26484336532743 0.470588235294118 3.1 3 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 6.82525017728955e-09 1.40758420322942e-07 1.26311543723272 0.469945355191257 3.1 3 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.05980982345387e-06 1.31231105771418e-05 1.26119477869668 0.469230769230769 3.1 3 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.000137558440534838 0.000854784545332205 1.25883936201101 0.468354430379747 3.1 3 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.0170201266950958 0.0499374026538584 1.2543030039497 0.466666666666667 3.1 3 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.0170201266950958 0.0499374026538584 1.2543030039497 0.466666666666667 3.1 3 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0832686953633294 0.175024155837545 1.2543030039497 0.466666666666667 3.1 3 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0832686953633294 0.175024155837545 1.2543030039497 0.466666666666667 3.1 3 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0832686953633294 0.175024155837545 1.2543030039497 0.466666666666667 3.1 3 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0832686953633294 0.175024155837545 1.2543030039497 0.466666666666667 3.1 3 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0832686953633294 0.175024155837545 1.2543030039497 0.466666666666667 3.1 3 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0832686953633294 0.175024155837545 1.2543030039497 0.466666666666667 3.1 3 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 7.13105629917145e-05 0.000483213957796237 1.25226679777446 0.465909090909091 3.1 3 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000287857276855459 0.00158767792622217 1.2518483992453 0.465753424657534 3.1 3 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 9.10402446073539e-05 0.000588864854892112 1.25013588433525 0.465116279069767 3.1 3 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00499278225227836 0.0185987673952673 1.25013588433525 0.465116279069767 3.1 3 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.0001162378974246 0.000731887292191178 1.24790349882751 0.464285714285714 3.1 3 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.0001162378974246 0.000731887292191178 1.24790349882751 0.464285714285714 3.1 3 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.000148421772391896 0.000914520420345851 1.24556221646573 0.463414634146341 3.1 3 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00060328031803644 0.00295686023320358 1.24360532374544 0.462686567164179 3.1 3 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00832998733344654 0.0272495907482631 1.24051945445575 0.461538461538462 3.1 3 1 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%REACT_207160.1 GLUCOCORTICOID BIOSYNTHESIS 0.111815160335059 0.21766480596004 1.24051945445575 0.461538461538462 3.1 3 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.111815160335059 0.21766480596004 1.24051945445575 0.461538461538462 3.1 3 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.111815160335059 0.21766480596004 1.24051945445575 0.461538461538462 3.1 3 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.111815160335059 0.21766480596004 1.24051945445575 0.461538461538462 3.1 3 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.31844388176198e-07 6.02465259190912e-06 1.23779901705563 0.460526315789474 3.1 3 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.000309148456949205 0.00167907730625465 1.23779901705563 0.460526315789474 3.1 3 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000309148456949205 0.00167907730625465 1.23779901705563 0.460526315789474 3.1 3 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.000988889168811627 0.00444125315482502 1.23723765695719 0.46031746031746 3.1 3 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.97319339340761e-05 0.000289941240965079 1.23638438960757 0.46 3.1 3 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.40777492123749e-08 4.50824172752756e-07 1.23609692520636 0.459893048128342 3.1 3 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.000124693083367408 0.000778237972069396 1.23576650635439 0.459770114942529 3.1 3 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.000124693083367408 0.000778237972069396 1.23576650635439 0.459770114942529 3.1 3 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000394880136435314 0.00207740472521552 1.23493152898523 0.459459459459459 3.1 3 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000394880136435314 0.00207740472521552 1.23493152898523 0.459459459459459 3.1 3 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 5.05865936210588e-05 0.000356648053816409 1.23419027356567 0.459183673469388 3.1 3 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00015898099258167 0.000942624801848818 1.23322228119425 0.458823529411765 3.1 3 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00015898099258167 0.000942624801848818 1.23322228119425 0.458823529411765 3.1 3 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.00015898099258167 0.000942624801848818 1.23322228119425 0.458823529411765 3.1 3 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00015898099258167 0.000942624801848818 1.23322228119425 0.458823529411765 3.1 3 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00015898099258167 0.000942624801848818 1.23322228119425 0.458823529411765 3.1 3 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00015898099258167 0.000942624801848818 1.23322228119425 0.458823529411765 3.1 3 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.00015898099258167 0.000942624801848818 1.23322228119425 0.458823529411765 3.1 3 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.000504430785243376 0.00253641345371493 1.23190473602203 0.458333333333333 3.1 3 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0379343791965766 0.0958820564757665 1.23190473602203 0.458333333333333 3.1 3 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0379343791965766 0.0958820564757665 1.23190473602203 0.458333333333333 3.1 3 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0379343791965766 0.0958820564757665 1.23190473602203 0.458333333333333 3.1 3 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.62178160461501e-05 0.000206121283058959 1.23085808798803 0.457943925233645 3.1 3 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 7.88395140897506e-08 1.26054638819905e-06 1.23000657772308 0.457627118644068 3.1 3 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000644430450951529 0.00309805585035144 1.22870498346093 0.457142857142857 3.1 3 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.0139452028689377 0.0427672924191774 1.22870498346093 0.457142857142857 3.1 3 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00010439078211094 0.000663161084570835 1.2270355473421 0.456521739130435 3.1 3 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00532427229266431 0.0195677152233483 1.2270355473421 0.456521739130435 3.1 3 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 4.58877733837331e-11 2.83905658804575e-09 1.22531701016095 0.455882352941176 3.1 3 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.79011472844799e-05 0.000218150179042939 1.22172370514582 0.454545454545455 3.1 3 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0180698272657081 0.0526913200801284 1.22172370514582 0.454545454545455 3.1 3 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0497729615912687 0.119745006848061 1.22172370514582 0.454545454545455 3.1 3 1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.151421270764471 0.271375904657232 1.22172370514582 0.454545454545455 3.1 3 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00882337360738258 0.028797386796572 1.21590597321655 0.452380952380952 3.1 3 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.00068310392966341 0.00322942489006988 1.21502932867926 0.452054794520548 3.1 3 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00171809875158194 0.007233297406808 1.21384161672552 0.451612903225806 3.1 3 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.000870989776122922 0.00394719252045516 1.21139927946853 0.450704225352113 3.1 3 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 9.2109361006827e-05 0.000593084256618619 1.20950646809436 0.45 3.1 3 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.00219585943341961 0.00867974437154475 1.20950646809436 0.45 3.1 3 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.00219585943341961 0.00867974437154475 1.20950646809436 0.45 3.1 3 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00219585943341961 0.00867974437154475 1.20950646809436 0.45 3.1 3 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.00219585943341961 0.00867974437154475 1.20950646809436 0.45 3.1 3 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.00219585943341961 0.00867974437154475 1.20950646809436 0.45 3.1 3 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.00219585943341961 0.00867974437154475 1.20950646809436 0.45 3.1 3 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.00219585943341961 0.00867974437154475 1.20950646809436 0.45 3.1 3 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 8.86439118548983e-07 1.13639897810379e-05 1.20950646809436 0.45 3.1 3 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 4.13270012183181e-06 4.29649589708879e-05 1.20950646809436 0.45 3.1 3 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.065489974731364 0.149346528914633 1.20950646809436 0.45 3.1 3 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.065489974731364 0.149346528914633 1.20950646809436 0.45 3.1 3 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.00141592728891587 0.00621871769175087 1.20348902297946 0.447761194029851 3.1 3 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.00141592728891587 0.00621871769175087 1.20348902297946 0.447761194029851 3.1 3 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 6.1556220506946e-07 8.34233350298897e-06 1.20160119706106 0.447058823529412 3.1 3 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000592582646575879 0.00291780313521618 1.19457428947591 0.444444444444444 3.1 3 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00116423696882655 0.00516108787115321 1.19457428947591 0.444444444444444 3.1 3 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0188996099842212 0.0548860102194832 1.19457428947591 0.444444444444444 3.1 3 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0395924664601869 0.0983247465494693 1.19457428947591 0.444444444444444 3.1 3 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0395924664601869 0.0983247465494693 1.19457428947591 0.444444444444444 3.1 3 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0395924664601869 0.0983247465494693 1.19457428947591 0.444444444444444 3.1 3 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0395924664601869 0.0983247465494693 1.19457428947591 0.444444444444444 3.1 3 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0864538688366159 0.179596869130664 1.19457428947591 0.444444444444444 3.1 3 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0864538688366159 0.179596869130664 1.19457428947591 0.444444444444444 3.1 3 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.72309073304321e-26 1.9133916226241e-23 1.19419190333971 0.444302176696543 3.1 3 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.53490895610893e-15 3.27925040413001e-13 1.19323508063121 0.443946188340807 3.1 3 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.02856705749806e-06 1.2952663033803e-05 1.19280716774592 0.443786982248521 3.1 3 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 2.06233859093226e-06 2.36669985072307e-05 1.18724561285336 0.441717791411043 3.1 3 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.024391936488266 0.0656138480582278 1.18579065499447 0.441176470588235 3.1 3 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.024391936488266 0.0656138480582278 1.18579065499447 0.441176470588235 3.1 3 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.024391936488266 0.0656138480582278 1.18579065499447 0.441176470588235 3.1 3 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.82796983631486e-05 0.000219901698200877 1.18516819270838 0.440944881889764 3.1 3 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00749510482678442 0.0249920154383196 1.18262854658115 0.44 3.1 3 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0515663344216818 0.123325872070678 1.18262854658115 0.44 3.1 3 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.0152185007840548 0.0454956441506513 1.18000631033596 0.439024390243902 3.1 3 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.0152185007840548 0.0454956441506513 1.18000631033596 0.439024390243902 3.1 3 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0152185007840548 0.0454956441506513 1.18000631033596 0.439024390243902 3.1 3 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 5.19715941711533e-06 5.13580406288549e-05 1.17916042767622 0.438709677419355 3.1 3 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 0.00153975543841731 0.00656009577505337 1.17821025811323 0.438356164383562 3.1 3 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00958187373905616 0.0305220694495475 1.17590906620285 0.4375 3.1 3 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.114573762368447 0.221519651970517 1.17590906620285 0.4375 3.1 3 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.000992525417033214 0.00444139518376813 1.17590906620285 0.4375 3.1 3 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.99425693770355e-05 0.000164036278748679 1.1711094373612 0.435714285714286 3.1 3 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00247852214194454 0.00976990860938248 1.16860528318295 0.434782608695652 3.1 3 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.0122493822453702 0.0378109998593532 1.16860528318295 0.434782608695652 3.1 3 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.41666267643765e-05 0.000500185354908567 1.16764741000002 0.434426229508197 3.1 3 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.000339981986231388 0.00183255441820934 1.167424873806 0.434343434343434 3.1 3 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 7.02034592864032e-06 6.70466594392965e-05 1.16640036755431 0.433962264150943 3.1 3 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0407088542207968 0.100745564445555 1.16470993223901 0.433333333333333 3.1 3 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 8.81842017686768e-06 7.92919528231037e-05 1.1641392757313 0.43312101910828 3.1 3 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.03667270673289e-06 2.36274231814458e-05 1.1603037155975 0.431693989071038 3.1 3 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.000286243847939804 0.00158492216193907 1.15549942953978 0.429906542056075 3.1 3 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.07024999377642e-12 8.015609163915e-11 1.15461493824344 0.429577464788732 3.1 3 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 6.08004557892567e-07 8.31913928731849e-06 1.15191092199463 0.428571428571429 3.1 3 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0879158562928518 0.181573677075077 1.15191092199463 0.428571428571429 3.1 3 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0322269867027623 0.0833800037782378 1.15191092199463 0.428571428571429 3.1 3 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.152551204908193 0.2720305320606 1.15191092199463 0.428571428571429 3.1 3 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.152551204908193 0.2720305320606 1.15191092199463 0.428571428571429 3.1 3 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.152551204908193 0.2720305320606 1.15191092199463 0.428571428571429 3.1 3 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.152551204908193 0.2720305320606 1.15191092199463 0.428571428571429 3.1 3 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 4.02876486471401e-11 2.60587836476729e-09 1.14985760484312 0.427807486631016 3.1 3 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00639631140666857 0.02258548667913 1.14561632679247 0.426229508196721 3.1 3 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0413972745887033 0.102094145129506 1.1402754581361 0.424242424242424 3.1 3 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.93908332821218e-05 0.000222463594470528 1.13714283325111 0.423076923076923 3.1 3 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0681282411430002 0.152192287514112 1.13714283325111 0.423076923076923 3.1 3 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.0681282411430002 0.152192287514112 1.13714283325111 0.423076923076923 3.1 3 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0681282411430002 0.152192287514112 1.13714283325111 0.423076923076923 3.1 3 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0681282411430002 0.152192287514112 1.13714283325111 0.423076923076923 3.1 3 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.11872430253483e-13 2.00996312167137e-11 1.13630237291611 0.422764227642276 3.1 3 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.11095152674208e-14 4.17848858753856e-12 1.13439136424566 0.422053231939163 3.1 3 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.05952010322944e-07 1.67521900766165e-06 1.13278596415819 0.421455938697318 3.1 3 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0326828555916956 0.084405995475468 1.13170195845086 0.421052631578947 3.1 3 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.115125080060099 0.222283567063123 1.13170195845086 0.421052631578947 3.1 3 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.000311765160482067 0.00168685103941438 1.12932443332807 0.420168067226891 3.1 3 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00821955011183106 0.0270125168802208 1.12713864410227 0.419354838709677 3.1 3 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0531806028032486 0.126973150652723 1.12713864410227 0.419354838709677 3.1 3 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.00020603613020904 0.00117746752324283 1.12512229590173 0.418604651162791 3.1 3 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.97189659803769e-07 5.75467485942659e-06 1.11991339638366 0.416666666666667 3.1 3 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.97189659803769e-07 5.75467485942659e-06 1.11991339638366 0.416666666666667 3.1 3 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.97189659803769e-07 5.75467485942659e-06 1.11991339638366 0.416666666666667 3.1 3 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0882253011827636 0.181948700845033 1.11991339638366 0.416666666666667 3.1 3 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.204276799699831 0.337669935598856 1.11991339638366 0.416666666666667 3.1 3 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.204276799699831 0.337669935598856 1.11991339638366 0.416666666666667 3.1 3 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.204276799699831 0.337669935598856 1.11991339638366 0.416666666666667 3.1 3 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.204276799699831 0.337669935598856 1.11991339638366 0.416666666666667 3.1 3 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.204276799699831 0.337669935598856 1.11991339638366 0.416666666666667 3.1 3 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.04275417743287e-08 8.44216375821997e-07 1.11914895037931 0.416382252559727 3.1 3 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.63704430990182e-13 2.34532128311894e-11 1.11739673706595 0.415730337078652 3.1 3 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 4.02384600962669e-07 5.75467485942659e-06 1.11727830603923 0.415686274509804 3.1 3 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.0130681892841602 0.0401642189014255 1.11218985571895 0.413793103448276 3.1 3 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.0130681892841602 0.0401642189014255 1.11218985571895 0.413793103448276 3.1 3 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.000173317291155588 0.00101494035108807 1.1089492092862 0.412587412587413 3.1 3 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.11432247570164 0.221334534589706 1.09955133463123 0.409090909090909 3.1 3 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.11432247570164 0.221334534589706 1.09955133463123 0.409090909090909 3.1 3 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.11432247570164 0.221334534589706 1.09955133463123 0.409090909090909 3.1 3 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.21591991981361e-06 1.47884961187587e-05 1.09579218476925 0.407692307692308 3.1 3 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.35226865574167e-21 4.78182613874342e-19 1.09502643201958 0.407407407407407 3.1 3 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0877465862374341 0.181487488685856 1.09502643201958 0.407407407407407 3.1 3 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0680141645525709 0.152192287514112 1.09191556147407 0.40625 3.1 3 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0104989446885229 0.0330530935658587 1.09069826430409 0.405797101449275 3.1 3 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0260224985594271 0.06960529219937 1.08545452264878 0.403846153846154 3.1 3 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 7.88177594658801e-06 7.21013122285592e-05 1.08434533143414 0.40343347639485 3.1 3 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.000270513838796275 0.00150367653362148 1.07854079957459 0.401273885350318 3.1 3 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.84804923533232e-13 3.22104356581053e-11 1.07846092541332 0.401244167962675 3.1 3 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.85922948466103e-06 2.2047362972272e-05 1.0770575046809 0.40072202166065 3.1 3 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0163612022966632 0.048302885618572 1.07511686052832 0.4 3.1 3 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0258700985044902 0.0693279664254042 1.07511686052832 0.4 3.1 3 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0867214205050705 0.179890060318827 1.07511686052832 0.4 3.1 3 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.112664612356818 0.219018775114415 1.07511686052832 0.4 3.1 3 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.198739544604768 0.337669935598856 1.07511686052832 0.4 3.1 3 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.067350360963174 0.151644879193982 1.07511686052832 0.4 3.1 3 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.148215150279256 0.270744748199463 1.07511686052832 0.4 3.1 3 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.148215150279256 0.270744748199463 1.07511686052832 0.4 3.1 3 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.148215150279256 0.270744748199463 1.07511686052832 0.4 3.1 3 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.148215150279256 0.270744748199463 1.07511686052832 0.4 3.1 3 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 9.00563702560571e-10 4.25703497702988e-08 1.06425709426036 0.395959595959596 3.1 3 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0409455350709162 0.101155375704711 1.06391772656448 0.395833333333333 3.1 3 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0102846323098628 0.0324501813235805 1.06184381286747 0.395061728395062 3.1 3 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0853151430290846 0.177750290674066 1.05882721112637 0.393939393939394 3.1 3 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0853151430290846 0.177750290674066 1.05882721112637 0.393939393939394 3.1 3 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0853151430290846 0.177750290674066 1.05882721112637 0.393939393939394 3.1 3 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0512449777964424 0.122763642094844 1.05174475486466 0.391304347826087 3.1 3 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.144570013424361 0.267160451150123 1.05174475486466 0.391304347826087 3.1 3 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.144570013424361 0.267160451150123 1.05174475486466 0.391304347826087 3.1 3 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.0250299465883065 0.067203045273887 1.04991880910969 0.390625 3.1 3 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00516007312482728 0.0191218334808053 1.04951884003955 0.39047619047619 3.1 3 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0652915719793613 0.149346528914633 1.04889449807641 0.390243902439024 3.1 3 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0652915719793613 0.149346528914633 1.04889449807641 0.390243902439024 3.1 3 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 2.04228605152343e-06 2.36274231814458e-05 1.04708467244706 0.389570552147239 3.1 3 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 7.89681903788083e-15 8.64397960838802e-13 1.0459281674823 0.389140271493213 3.1 3 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0196577636720335 0.055949266158908 1.04525250329142 0.388888888888889 3.1 3 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.083643700620463 0.175294530166302 1.04525250329142 0.388888888888889 3.1 3 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.192211711280418 0.328746712923119 1.04525250329142 0.388888888888889 3.1 3 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.00503066689284776 0.0186909634165075 1.04121677934049 0.387387387387387 3.1 3 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.107905094843064 0.2112090095759 1.04043567147902 0.387096774193548 3.1 3 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.107905094843064 0.2112090095759 1.04043567147902 0.387096774193548 3.1 3 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.107905094843064 0.2112090095759 1.04043567147902 0.387096774193548 3.1 3 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.140499844365454 0.263761581176836 1.03376621204646 0.384615384615385 3.1 3 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.262065324302813 0.413435650202775 1.03376621204646 0.384615384615385 3.1 3 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.262065324302813 0.413435650202775 1.03376621204646 0.384615384615385 3.1 3 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.262065324302813 0.413435650202775 1.03376621204646 0.384615384615385 3.1 3 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.262065324302813 0.413435650202775 1.03376621204646 0.384615384615385 3.1 3 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.262065324302813 0.413435650202775 1.03376621204646 0.384615384615385 3.1 3 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.262065324302813 0.413435650202775 1.03376621204646 0.384615384615385 3.1 3 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.105133415077226 0.207776920324241 1.02768523432854 0.382352941176471 3.1 3 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.105133415077226 0.207776920324241 1.02768523432854 0.382352941176471 3.1 3 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.105133415077226 0.207776920324241 1.02768523432854 0.382352941176471 3.1 3 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00738731490146135 0.0247344684818341 1.02624791232249 0.381818181818182 3.1 3 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.048345757060099 0.117199339517071 1.02624791232249 0.381818181818182 3.1 3 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0798145477386569 0.169516569301655 1.02392081955078 0.380952380952381 3.1 3 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.185322408117044 0.318110719843852 1.02392081955078 0.380952380952381 3.1 3 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.00189632516580987 0.00789026523668844 1.02309507695437 0.380645161290323 3.1 3 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.0141511105805327 0.0431199793492464 1.01853176260578 0.378947368421053 3.1 3 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.0141511105805327 0.0431199793492464 1.01853176260578 0.378947368421053 3.1 3 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.099269358583205 0.199520193875566 1.0079220567453 0.375 3.1 3 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.099269358583205 0.199520193875566 1.0079220567453 0.375 3.1 3 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.131839653017359 0.24848718707775 1.0079220567453 0.375 3.1 3 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.178376840769319 0.310560380777869 1.0079220567453 0.375 3.1 3 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.178376840769319 0.310560380777869 1.0079220567453 0.375 3.1 3 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.249239013946561 0.397608875387843 1.0079220567453 0.375 3.1 3 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.249239013946561 0.397608875387843 1.0079220567453 0.375 3.1 3 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.249239013946561 0.397608875387843 1.0079220567453 0.375 3.1 3 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.249239013946561 0.397608875387843 1.0079220567453 0.375 3.1 3 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.249239013946561 0.397608875387843 1.0079220567453 0.375 3.1 3 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.249239013946561 0.397608875387843 1.0079220567453 0.375 3.1 3 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.0164689522345951 0.0485203292543039 1.00452837978656 0.373737373737374 3.1 3 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.0267079150421605 0.0713046212101208 1.00387417699933 0.373493975903614 3.1 3 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.171531172676054 0.301716759849227 0.995478574563258 0.37037037037037 3.1 3 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.171531172676054 0.301716759849227 0.995478574563258 0.37037037037037 3.1 3 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.0194552300018236 0.055949266158908 0.994483095988694 0.37 3.1 3 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0933058605019736 0.188599772008961 0.993314490705511 0.369565217391304 3.1 3 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.0933058605019736 0.188599772008961 0.993314490705511 0.369565217391304 3.1 3 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00704726432440193 0.0243404299359805 0.991242495522563 0.368794326241135 3.1 3 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.237178912825604 0.380931820486269 0.990239213644504 0.368421052631579 3.1 3 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.16486676856906 0.290713025618057 0.985523788817625 0.366666666666667 3.1 3 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0874614117111192 0.181160973602508 0.982077901444137 0.365384615384615 3.1 3 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.225893798068703 0.364039495641863 0.977378964116653 0.363636363636364 3.1 3 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.225893798068703 0.364039495641863 0.977378964116653 0.363636363636364 3.1 3 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.225893798068703 0.364039495641863 0.977378964116653 0.363636363636364 3.1 3 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.158425087296372 0.281446815509036 0.977378964116653 0.363636363636364 3.1 3 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.158425087296372 0.281446815509036 0.977378964116653 0.363636363636364 3.1 3 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 0.00159129790231241 0.00673933605651951 0.976283247789168 0.36322869955157 3.1 3 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.0157057862007338 0.0466583168343302 0.975408442011579 0.362903225806452 3.1 3 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.0157057862007338 0.0466583168343302 0.975408442011579 0.362903225806452 3.1 3 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.0157057862007338 0.0466583168343302 0.975408442011579 0.362903225806452 3.1 3 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0320138186012508 0.0829793513107103 0.967605174475487 0.36 3.1 3 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.106764173567021 0.20984173893076 0.967605174475487 0.36 3.1 3 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.106764173567021 0.20984173893076 0.967605174475487 0.36 3.1 3 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.215339969251351 0.349007717818534 0.967605174475487 0.36 3.1 3 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.146274121292159 0.26857816077257 0.964848464576696 0.358974358974359 3.1 3 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.102974139175608 0.206383380347732 0.963548129718776 0.358490566037736 3.1 3 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.102974139175608 0.206383380347732 0.963548129718776 0.358490566037736 3.1 3 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0739569395578147 0.158734125174616 0.962791218383569 0.358208955223881 3.1 3 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.205459930083714 0.337669935598856 0.959925768328855 0.357142857142857 3.1 3 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.205459930083714 0.337669935598856 0.959925768328855 0.357142857142857 3.1 3 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.205459930083714 0.337669935598856 0.959925768328855 0.357142857142857 3.1 3 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.205459930083714 0.337669935598856 0.959925768328855 0.357142857142857 3.1 3 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.322906501744268 0.466020235275957 0.959925768328855 0.357142857142857 3.1 3 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.135109250764767 0.254312782854847 0.955659431580727 0.355555555555556 3.1 3 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.196195689118357 0.335157821867254 0.953732698855766 0.354838709677419 3.1 3 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.124882342812607 0.239812819600843 0.948632523995575 0.352941176470588 3.1 3 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.124882342812607 0.239812819600843 0.948632523995575 0.352941176470588 3.1 3 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.302778297131324 0.445918538206216 0.948632523995575 0.352941176470588 3.1 3 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.302778297131324 0.445918538206216 0.948632523995575 0.352941176470588 3.1 3 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.0400042072787881 0.0991741933061245 0.945704645835095 0.351851851851852 3.1 3 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.037438227853173 0.0953033957693474 0.943084965375718 0.350877192982456 3.1 3 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.285082477273637 0.434338720728464 0.940727252962278 0.35 3.1 3 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.285082477273637 0.434338720728464 0.940727252962278 0.35 3.1 3 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.285082477273637 0.434338720728464 0.940727252962278 0.35 3.1 3 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.285082477273637 0.434338720728464 0.940727252962278 0.35 3.1 3 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.285082477273637 0.434338720728464 0.940727252962278 0.35 3.1 3 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.164295930506013 0.290065892196099 0.93760191325144 0.348837209302326 3.1 3 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.164295930506013 0.290065892196099 0.93760191325144 0.348837209302326 3.1 3 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.0457819462005375 0.111173565603012 0.937028456423764 0.348623853211009 3.1 3 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.0990880738907 0.199520193875566 0.934884226546364 0.347826086956522 3.1 3 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.269266483212352 0.419421449736753 0.934884226546364 0.347826086956522 3.1 3 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.150879291288266 0.271375904657232 0.932499317805174 0.346938775510204 3.1 3 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.144693423983982 0.267160451150123 0.930389590841814 0.346153846153846 3.1 3 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.254961211838002 0.405374083179304 0.930389590841814 0.346153846153846 3.1 3 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0852482998866152 0.177750290674066 0.92911333625904 0.345679012345679 3.1 3 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.138822418364731 0.260956804931324 0.92851001591082 0.345454545454545 3.1 3 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.218815101834127 0.354236507292335 0.921528737595701 0.342857142857143 3.1 3 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.104938723331836 0.207776920324241 0.919507841241325 0.342105263157895 3.1 3 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.198916759802403 0.337669935598856 0.917782685816857 0.341463414634146 3.1 3 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.198916759802403 0.337669935598856 0.917782685816857 0.341463414634146 3.1 3 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.0899919616492752 0.185055724605374 0.916292778859362 0.340909090909091 3.1 3 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0834478374540586 0.175141995128504 0.914993072790058 0.340425531914894 3.1 3 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.105818708600229 0.208559587725936 0.906348516143059 0.337209302325581 3.1 3 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.0942291300590187 0.190195818544658 0.905361566760689 0.336842105263158 3.1 3 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.119152281864331 0.229747557036508 0.895930717106932 0.333333333333333 3.1 3 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.189174486489409 0.323941389018566 0.895930717106932 0.333333333333333 3.1 3 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.207338528116127 0.337669935598856 0.895930717106932 0.333333333333333 3.1 3 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.228089903581663 0.366747946662946 0.895930717106932 0.333333333333333 3.1 3 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.228089903581663 0.366747946662946 0.895930717106932 0.333333333333333 3.1 3 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.280424765423766 0.430004785773727 0.895930717106932 0.333333333333333 3.1 3 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.280424765423766 0.430004785773727 0.895930717106932 0.333333333333333 3.1 3 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.296676231418976 0.44017987024529 0.895930717106932 0.333333333333333 3.1 3 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.296676231418976 0.44017987024529 0.895930717106932 0.333333333333333 3.1 3 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.314711304433869 0.46120925459258 0.895930717106932 0.333333333333333 3.1 3 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.314711304433869 0.46120925459258 0.895930717106932 0.333333333333333 3.1 3 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.334962511851933 0.481466317540708 0.895930717106932 0.333333333333333 3.1 3 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.384989980314018 0.530853432157799 0.895930717106932 0.333333333333333 3.1 3 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.384989980314018 0.530853432157799 0.895930717106932 0.333333333333333 3.1 3 1 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_220332.1 ANDROGEN BIOSYNTHESIS 0.384989980314018 0.530853432157799 0.895930717106932 0.333333333333333 3.1 3 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.384989980314018 0.530853432157799 0.895930717106932 0.333333333333333 3.1 3 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.384989980314018 0.530853432157799 0.895930717106932 0.333333333333333 3.1 3 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.145995377890807 0.268412690876769 0.895930717106932 0.333333333333333 3.1 3 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.25210996926395 0.401289134521925 0.895930717106932 0.333333333333333 3.1 3 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.358061590056777 0.504976850991867 0.895930717106932 0.333333333333333 3.1 3 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.358061590056777 0.504976850991867 0.895930717106932 0.333333333333333 3.1 3 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0600928402820847 0.142046697211639 0.88480114298138 0.329192546583851 3.1 3 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0664107238436466 0.151203936047215 0.879339407530878 0.327160493827161 3.1 3 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.303024052315819 0.445918538206216 0.86957981366261 0.323529411764706 3.1 3 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.208906130902617 0.339741056313627 0.868363618119026 0.323076923076923 3.1 3 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.320533849378722 0.466020235275957 0.867029726232515 0.32258064516129 3.1 3 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.089686936944682 0.18469538534339 0.867029726232515 0.32258064516129 3.1 3 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.042071980301212 0.103578595101427 0.864309632973746 0.32156862745098 3.1 3 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.3398839531041 0.4880472908851 0.86393319149597 0.321428571428571 3.1 3 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.251086362891893 0.400107384541057 0.86212201080101 0.320754716981132 3.1 3 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.36147428569623 0.508133674699409 0.860093488422655 0.32 3.1 3 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.36147428569623 0.508133674699409 0.860093488422655 0.32 3.1 3 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.36147428569623 0.508133674699409 0.860093488422655 0.32 3.1 3 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0739033046786188 0.158734125174616 0.859547743823402 0.319796954314721 3.1 3 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 0.0700909441513206 0.156331369165093 0.857533686373778 0.319047619047619 3.1 3 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.385861244950774 0.531025678496085 0.855206593602071 0.318181818181818 3.1 3 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.385861244950774 0.531025678496085 0.855206593602071 0.318181818181818 3.1 3 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.164031095284788 0.290065892196099 0.854064795746795 0.317757009345794 3.1 3 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.306523294820113 0.450601909637418 0.852226779687082 0.317073170731707 3.1 3 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.266562656490604 0.419421449736753 0.848776468838146 0.315789473684211 3.1 3 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.413853594932703 0.556629173524799 0.848776468838146 0.315789473684211 3.1 3 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.413853594932703 0.556629173524799 0.848776468838146 0.315789473684211 3.1 3 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.155696042047556 0.277290948477687 0.846548709077416 0.31496062992126 3.1 3 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.16329871446702 0.289382404341929 0.841217390871394 0.312977099236641 3.1 3 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.16329871446702 0.289382404341929 0.841217390871394 0.312977099236641 3.1 3 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.361728329213283 0.508133674699409 0.839935047287749 0.3125 3.1 3 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.446694965026499 0.589107446925587 0.839935047287749 0.3125 3.1 3 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.446694965026499 0.589107446925587 0.839935047287749 0.3125 3.1 3 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.446694965026499 0.589107446925587 0.839935047287749 0.3125 3.1 3 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.446694965026499 0.589107446925587 0.839935047287749 0.3125 3.1 3 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.281221384782487 0.430762142675436 0.837181161886805 0.311475409836066 3.1 3 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.324350349138902 0.466684071612393 0.836202002633136 0.311111111111111 3.1 3 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.383974287088457 0.530853432157799 0.834142391789212 0.310344827586207 3.1 3 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.383974287088457 0.530853432157799 0.834142391789212 0.310344827586207 3.1 3 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.341683090892521 0.489642536092707 0.831935665885008 0.30952380952381 3.1 3 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.324333465959056 0.466684071612393 0.827012969637168 0.307692307692308 3.1 3 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.324333465959056 0.466684071612393 0.827012969637168 0.307692307692308 3.1 3 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.408813429633222 0.554870057851325 0.827012969637168 0.307692307692308 3.1 3 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.408813429633222 0.554870057851325 0.827012969637168 0.307692307692308 3.1 3 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.408813429633222 0.554870057851325 0.827012969637168 0.307692307692308 3.1 3 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.408813429633222 0.554870057851325 0.827012969637168 0.307692307692308 3.1 3 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.408813429633222 0.554870057851325 0.827012969637168 0.307692307692308 3.1 3 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.340780269417506 0.488841051795475 0.822793515710448 0.306122448979592 3.1 3 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.381004156176558 0.52946183031176 0.821269824014688 0.305555555555556 3.1 3 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.187156401650395 0.320871758492183 0.819448826622194 0.304878048780488 3.1 3 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.403503060625211 0.552100822374688 0.814482470097211 0.303030303030303 3.1 3 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.214998126684707 0.348851008292289 0.811408951342127 0.30188679245283 3.1 3 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.214998126684707 0.348851008292289 0.811408951342127 0.30188679245283 3.1 3 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.222126591750927 0.35918879552451 0.807986597636313 0.300613496932515 3.1 3 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.428352653516182 0.570735792091317 0.806337645396239 0.3 3.1 3 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.469041216786589 0.599681627571713 0.806337645396239 0.3 3.1 3 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.469041216786589 0.599681627571713 0.806337645396239 0.3 3.1 3 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.256710478128957 0.407699788367752 0.804375753314983 0.299270072992701 3.1 3 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.393136496328498 0.540515202198504 0.800618938691301 0.297872340425532 3.1 3 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.42075109471636 0.562186673973126 0.799073342284561 0.297297297297297 3.1 3 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.383461687043981 0.530853432157799 0.79311899547171 0.295081967213115 3.1 3 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.302460160939643 0.445918538206216 0.790527103329646 0.294117647058824 3.1 3 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.445369314087458 0.589107446925587 0.790527103329646 0.294117647058824 3.1 3 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.506660243316155 0.64201026379242 0.790527103329646 0.294117647058824 3.1 3 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.506660243316155 0.64201026379242 0.790527103329646 0.294117647058824 3.1 3 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.506660243316155 0.64201026379242 0.790527103329646 0.294117647058824 3.1 3 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.506660243316155 0.64201026379242 0.790527103329646 0.294117647058824 3.1 3 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.401510257120995 0.549902883429428 0.787801147800923 0.293103448275862 3.1 3 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.401510257120995 0.549902883429428 0.787801147800923 0.293103448275862 3.1 3 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.401510257120995 0.549902883429428 0.787801147800923 0.293103448275862 3.1 3 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.310607398779344 0.45613449789784 0.787139130029662 0.292857142857143 3.1 3 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.436197766390964 0.578480355614485 0.786670873557306 0.292682926829268 3.1 3 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.436197766390964 0.578480355614485 0.786670873557306 0.292682926829268 3.1 3 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.436197766390964 0.578480355614485 0.786670873557306 0.292682926829268 3.1 3 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.436197766390964 0.578480355614485 0.786670873557306 0.292682926829268 3.1 3 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.321326009521369 0.466020235275957 0.784756832502422 0.291970802919708 3.1 3 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.428064803947691 0.570735792091317 0.783939377468565 0.291666666666667 3.1 3 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.47246034611787 0.603510837096704 0.780326753609263 0.290322580645161 3.1 3 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.348494655197678 0.492460669658685 0.776052663409526 0.288732394366197 3.1 3 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.34545416207037 0.489934993585145 0.77001612983785 0.286486486486487 3.1 3 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.522672698760451 0.655875882130619 0.767940614663085 0.285714285714286 3.1 3 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.444561867198647 0.589023777489455 0.767940614663084 0.285714285714286 3.1 3 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.399155082369927 0.548260311015836 0.767940614663084 0.285714285714286 3.1 3 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.502487147613267 0.638998401299088 0.767940614663084 0.285714285714286 3.1 3 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.502487147613267 0.638998401299088 0.767940614663084 0.285714285714286 3.1 3 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.502487147613267 0.638998401299088 0.767940614663084 0.285714285714286 3.1 3 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.43449349503531 0.578376280107808 0.760183638757397 0.282828282828283 3.1 3 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.515790265776186 0.647810722153144 0.755941542558974 0.28125 3.1 3 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.563813571492839 0.697051878570208 0.746608930922443 0.277777777777778 3.1 3 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.563813571492839 0.697051878570208 0.746608930922443 0.277777777777778 3.1 3 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.54763490400367 0.682983758455059 0.741459903812633 0.275862068965517 3.1 3 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.492643724835513 0.628164892868221 0.737503943959974 0.274390243902439 3.1 3 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.425268931112923 0.567690139750177 0.734226148653486 0.273170731707317 3.1 3 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.535387646724247 0.670187087381156 0.73303422308749 0.272727272727273 3.1 3 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.556819469383985 0.689603224485127 0.727943707649382 0.270833333333333 3.1 3 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.556819469383985 0.689603224485127 0.727943707649382 0.270833333333333 3.1 3 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.572773095719779 0.707513988896914 0.718828133492771 0.267441860465116 3.1 3 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.591010267817302 0.72877609281111 0.716744573685546 0.266666666666667 3.1 3 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.585104749664782 0.722119738745 0.714476394654895 0.265822784810127 3.1 3 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.617370705978602 0.738250852611387 0.707313724031788 0.263157894736842 3.1 3 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.617370705978602 0.738250852611387 0.707313724031788 0.263157894736842 3.1 3 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.627350753243907 0.748298509527309 0.69683500219428 0.259259259259259 3.1 3 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.627350753243907 0.748298509527309 0.69683500219428 0.259259259259259 3.1 3 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.627350753243907 0.748298509527309 0.69683500219428 0.259259259259259 3.1 3 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.628843343375624 0.749450651275974 0.69683500219428 0.259259259259259 3.1 3 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.632245023191019 0.752874199163866 0.693623780986012 0.258064516129032 3.1 3 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.637017996327659 0.757923585931655 0.691146553196776 0.257142857142857 3.1 3 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.648338806285171 0.768821767786499 0.691146553196776 0.257142857142857 3.1 3 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.641657928415495 0.762169642850793 0.68917747469764 0.256410256410256 3.1 3 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.641657928415495 0.762169642850793 0.68917747469764 0.256410256410256 3.1 3 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.646162771208418 0.766880419874545 0.68757473638439 0.255813953488372 3.1 3 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.696812416004581 0.813424173892141 0.682963579433973 0.254098360655738 3.1 3 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.667432016064478 0.787990737747038 0.671948037830199 0.25 3.1 3 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.667432016064478 0.787990737747038 0.671948037830199 0.25 3.1 3 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.67891735942997 0.797111718208619 0.671948037830199 0.25 3.1 3 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.681773767622703 0.798444280319558 0.671948037830199 0.25 3.1 3 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.707675960534867 0.821796325326082 0.653787280051004 0.243243243243243 3.1 3 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.707675960534867 0.821796325326082 0.653787280051004 0.243243243243243 3.1 3 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.707675960534867 0.821796325326082 0.653787280051004 0.243243243243243 3.1 3 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.707276174208174 0.821796325326082 0.651585976077769 0.242424242424242 3.1 3 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.707276174208174 0.821796325326082 0.651585976077769 0.242424242424242 3.1 3 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.707276174208174 0.821796325326082 0.651585976077769 0.242424242424242 3.1 3 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.791580396154222 0.890498765504642 0.646103882529037 0.240384615384615 3.1 3 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.708919367212784 0.821796325326082 0.645070116316991 0.24 3.1 3 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.711857984755779 0.821796325326082 0.639950512219237 0.238095238095238 3.1 3 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.764680535689768 0.869121727065927 0.635296326675824 0.236363636363636 3.1 3 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.746714969497145 0.850488403506998 0.620259727227876 0.230769230769231 3.1 3 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.925741118994358 1 0.619306947308939 0.230414746543779 3.1 3 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.790670095472743 0.890498765504642 0.615952368011016 0.229166666666667 3.1 3 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.959374592979226 1 0.604483375397448 0.224899598393574 3.1 3 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99232381880773 1 0.588820445521308 0.219072164948454 3.1 3 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.983029002224943 1 0.585554718680602 0.217857142857143 3.1 3 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.788534559728026 0.890498765504642 0.584302641591477 0.217391304347826 3.1 3 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.961481019477706 1 0.580318759944263 0.215909090909091 3.1 3 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.811322779328239 0.901962746081316 0.575955460997313 0.214285714285714 3.1 3 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.888301037296831 0.971324936332205 0.575955460997313 0.214285714285714 3.1 3 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.886881190692574 0.971324936332205 0.557843654047712 0.207547169811321 3.1 3 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.838386322111766 0.930595738194261 0.556094927859475 0.206896551724138 3.1 3 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.848274720904056 0.93403662520974 0.537558430264159 0.2 3.1 3 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.848274720904056 0.93403662520974 0.537558430264159 0.2 3.1 3 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.848274720904056 0.93403662520974 0.537558430264159 0.2 3.1 3 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.862218727802529 0.945980917242097 0.537558430264159 0.2 3.1 3 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.896185453017921 0.976471592377107 0.537558430264159 0.2 3.1 3 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.910304014436418 0.989690369183077 0.52587237743233 0.195652173913043 3.1 3 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.901170700428265 0.981152185699633 0.503961028372649 0.1875 3.1 3 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.933696488456067 1 0.503961028372649 0.1875 3.1 3 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.922631131931858 0.999165982297591 0.495119606822252 0.184210526315789 3.1 3 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.943261143199659 1 0.493676109426269 0.183673469387755 3.1 3 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.911099356029396 0.989690369183077 0.479962884164428 0.178571428571429 3.1 3 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.911099356029396 0.989690369183077 0.479962884164428 0.178571428571429 3.1 3 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.949821613779902 1 0.433514863116257 0.161290322580645 3.1 3 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.383647914126394 0.142737195633921 3.1 3 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.999636659666547 1 0.360219566671859 0.134020618556701 3.1 3 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.345087238234677 0.128390596745027 3.1 3 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.998463248532058 1 0.285935335246893 0.106382978723404 3.1 3 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0563569322051135 0.0209677419354839 3.1 3 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0005388742952309 0.00183889237916923 1.30728422770863 1 30.3 30 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0005388742952309 0.00183889237916923 1.30728422770863 1 30.3 30 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0005388742952309 0.00183889237916923 1.30728422770863 1 30.3 30 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0005388742952309 0.00183889237916923 1.30728422770863 1 30.3 30 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00124371967315762 0.00375756495733183 1.30728422770863 1 30.3 30 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.00124371967315762 0.00375756495733183 1.30728422770863 1 30.3 30 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00124371967315762 0.00375756495733183 1.30728422770863 1 30.3 30 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00124371967315762 0.00375756495733183 1.30728422770863 1 30.3 30 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00124371967315762 0.00375756495733183 1.30728422770863 1 30.3 30 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00124371967315762 0.00375756495733183 1.30728422770863 1 30.3 30 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00287038923206906 0.00790980466233125 1.30728422770863 1 30.3 30 3 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00287038923206906 0.00790980466233125 1.30728422770863 1 30.3 30 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 4.38209566672293e-05 0.00019671047740526 1.30728422770863 1 30.3 30 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 4.38209566672293e-05 0.00019671047740526 1.30728422770863 1 30.3 30 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.000233472472184073 0.000878918856925757 1.30728422770863 1 30.3 30 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000233472472184073 0.000878918856925757 1.30728422770863 1 30.3 30 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000233472472184073 0.000878918856925757 1.30728422770863 1 30.3 30 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000233472472184073 0.000878918856925757 1.30728422770863 1 30.3 30 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00662433571295628 0.0161411467800288 1.30728422770863 1 30.3 30 3 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00662433571295628 0.0161411467800288 1.30728422770863 1 30.3 30 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00662433571295628 0.0161411467800288 1.30728422770863 1 30.3 30 3 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.00662433571295628 0.0161411467800288 1.30728422770863 1 30.3 30 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00662433571295628 0.0161411467800288 1.30728422770863 1 30.3 30 3 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0152871712510385 0.0325653363626165 1.30728422770863 1 30.3 30 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.78955860945393e-08 2.61154072450851e-07 1.25499285860029 0.96 30.3 30 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 3.03489515327224e-07 2.056502763384e-06 1.24786221735824 0.954545454545455 30.3 30 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 6.69974189036437e-07 4.02267202953101e-06 1.24503259781774 0.952380952380952 30.3 30 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 1.47583543696184e-06 8.60702388031433e-06 1.2419200163232 0.95 30.3 30 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 1.55378327459108e-05 7.94396271439103e-05 1.23038515549048 0.941176470588235 30.3 30 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 3.38507544069051e-05 0.00015538588232589 1.22557896347684 0.9375 30.3 30 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 3.38507544069051e-05 0.00015538588232589 1.22557896347684 0.9375 30.3 30 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 3.38507544069051e-05 0.00015538588232589 1.22557896347684 0.9375 30.3 30 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 3.38507544069051e-05 0.00015538588232589 1.22557896347684 0.9375 30.3 30 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 2.13693496179537e-08 2.05463408826676e-07 1.21712669476321 0.931034482758621 30.3 30 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000158864594565769 0.000636800895963634 1.2139067828723 0.928571428571429 30.3 30 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000158864594565769 0.000636800895963634 1.2139067828723 0.928571428571429 30.3 30 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000158864594565769 0.000636800895963634 1.2139067828723 0.928571428571429 30.3 30 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000158864594565769 0.000636800895963634 1.2139067828723 0.928571428571429 30.3 30 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 9.89454028472513e-08 8.09191426733555e-07 1.21044835898947 0.925925925925926 30.3 30 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000341868588691581 0.00123786005523694 1.20672390250027 0.923076923076923 30.3 30 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000341868588691581 0.00123786005523694 1.20672390250027 0.923076923076923 30.3 30 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000341868588691581 0.00123786005523694 1.20672390250027 0.923076923076923 30.3 30 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.42261531461045e-09 2.20041477466377e-08 1.19834387539958 0.916666666666667 30.3 30 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00073177299159847 0.00236125389352522 1.19834387539958 0.916666666666667 30.3 30 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.0494643576609e-06 1.18072379795605e-05 1.19360733834266 0.91304347826087 30.3 30 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00155669426490981 0.00459609067088411 1.18844020700785 0.909090909090909 30.3 30 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00155669426490981 0.00459609067088411 1.18844020700785 0.909090909090909 30.3 30 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00155669426490981 0.00459609067088411 1.18844020700785 0.909090909090909 30.3 30 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00155669426490981 0.00459609067088411 1.18844020700785 0.909090909090909 30.3 30 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.91508941786572e-05 9.56200786534359e-05 1.17655580493777 0.9 30.3 30 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00328749070265234 0.0087769217070812 1.17655580493777 0.9 30.3 30 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00328749070265234 0.0087769217070812 1.17655580493777 0.9 30.3 30 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00328749070265234 0.0087769217070812 1.17655580493777 0.9 30.3 30 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00328749070265234 0.0087769217070812 1.17655580493777 0.9 30.3 30 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00328749070265234 0.0087769217070812 1.17655580493777 0.9 30.3 30 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00328749070265234 0.0087769217070812 1.17655580493777 0.9 30.3 30 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00328749070265234 0.0087769217070812 1.17655580493777 0.9 30.3 30 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 8.29673205664731e-05 0.000355609931223166 1.16203042462989 0.888888888888889 30.3 30 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 8.29673205664731e-05 0.000355609931223166 1.16203042462989 0.888888888888889 30.3 30 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00688248269657137 0.0165465446983676 1.16203042462989 0.888888888888889 30.3 30 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00688248269657137 0.0165465446983676 1.16203042462989 0.888888888888889 30.3 30 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00688248269657137 0.0165465446983676 1.16203042462989 0.888888888888889 30.3 30 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00688248269657137 0.0165465446983676 1.16203042462989 0.888888888888889 30.3 30 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00688248269657137 0.0165465446983676 1.16203042462989 0.888888888888889 30.3 30 3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.00688248269657137 0.0165465446983676 1.16203042462989 0.888888888888889 30.3 30 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000171197666864361 0.000674831800409931 1.15348608327232 0.882352941176471 30.3 30 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000171197666864361 0.000674831800409931 1.15348608327232 0.882352941176471 30.3 30 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.000171197666864361 0.000674831800409931 1.15348608327232 0.882352941176471 30.3 30 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000171197666864361 0.000674831800409931 1.15348608327232 0.882352941176471 30.3 30 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.0471284757543e-09 4.68216570812875e-08 1.14785932189051 0.878048780487805 30.3 30 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.0471284757543e-09 4.68216570812875e-08 1.14785932189051 0.878048780487805 30.3 30 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000350901548035294 0.00125248691448088 1.14387369924505 0.875 30.3 30 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000350901548035294 0.00125248691448088 1.14387369924505 0.875 30.3 30 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000350901548035294 0.00125248691448088 1.14387369924505 0.875 30.3 30 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0142570761444491 0.0312601222704948 1.14387369924505 0.875 30.3 30 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.95705313825798e-05 9.63628586761627e-05 1.13676889365968 0.869565217391304 30.3 30 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 1.95705313825798e-05 9.63628586761627e-05 1.13676889365968 0.869565217391304 30.3 30 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.95705313825798e-05 9.63628586761627e-05 1.13676889365968 0.869565217391304 30.3 30 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.13879951808998e-06 6.69632939769437e-06 1.13297966401415 0.866666666666667 30.3 30 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.000713850785775323 0.00235141126888492 1.13297966401415 0.866666666666667 30.3 30 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000713850785775323 0.00235141126888492 1.13297966401415 0.866666666666667 30.3 30 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000713850785775323 0.00235141126888492 1.13297966401415 0.866666666666667 30.3 30 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000713850785775323 0.00235141126888492 1.13297966401415 0.866666666666667 30.3 30 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 3.9510594277709e-05 0.000178487541768825 1.12901819665745 0.863636363636364 30.3 30 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.89083193411519e-15 9.2781166973997e-14 1.12753264639869 0.8625 30.3 30 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.36190053094877e-07 1.07665803085561e-06 1.12571697386021 0.861111111111111 30.3 30 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.36190053094877e-07 1.07665803085561e-06 1.12571697386021 0.861111111111111 30.3 30 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 6.19500064968065e-11 1.19128188168859e-09 1.12052933803597 0.857142857142857 30.3 30 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 4.58018863403751e-06 2.54594079149819e-05 1.12052933803597 0.857142857142857 30.3 30 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 4.58018863403751e-06 2.54594079149819e-05 1.12052933803597 0.857142857142857 30.3 30 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0291480145982796 0.0569747593040547 1.12052933803597 0.857142857142857 30.3 30 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 7.92671554970817e-05 0.000341809582643477 1.12052933803597 0.857142857142857 30.3 30 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 9.11369379026952e-06 4.75047115881081e-05 1.11361249027032 0.851851851851852 30.3 30 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.98838987867285e-11 6.0749697105021e-10 1.11119159355234 0.85 30.3 30 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.98838987867285e-11 6.0749697105021e-10 1.11119159355234 0.85 30.3 30 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.98838987867285e-11 6.0749697105021e-10 1.11119159355234 0.85 30.3 30 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.98838987867285e-11 6.0749697105021e-10 1.11119159355234 0.85 30.3 30 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.98838987867285e-11 6.0749697105021e-10 1.11119159355234 0.85 30.3 30 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.98838987867285e-11 6.0749697105021e-10 1.11119159355234 0.85 30.3 30 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.98838987867285e-11 6.0749697105021e-10 1.11119159355234 0.85 30.3 30 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000157934887351739 0.000636800895963634 1.11119159355234 0.85 30.3 30 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000157934887351739 0.000636800895963634 1.11119159355234 0.85 30.3 30 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000157934887351739 0.000636800895963634 1.11119159355234 0.85 30.3 30 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000157934887351739 0.000636800895963634 1.11119159355234 0.85 30.3 30 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.80303867152604e-05 9.06616264869806e-05 1.10616357729192 0.846153846153846 30.3 30 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00287624720758636 0.00790980466233125 1.10616357729192 0.846153846153846 30.3 30 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00287624720758636 0.00790980466233125 1.10616357729192 0.846153846153846 30.3 30 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.00287624720758636 0.00790980466233125 1.10616357729192 0.846153846153846 30.3 30 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00287624720758636 0.00790980466233125 1.10616357729192 0.846153846153846 30.3 30 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00287624720758636 0.00790980466233125 1.10616357729192 0.846153846153846 30.3 30 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00287624720758636 0.00790980466233125 1.10616357729192 0.846153846153846 30.3 30 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.53327059090884e-08 1.53650989497414e-07 1.1039289033984 0.844444444444444 30.3 30 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000312294400096358 0.00114830731611658 1.10087092859674 0.842105263157895 30.3 30 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.00287694172046e-08 2.75683476649562e-07 1.09930719148226 0.840909090909091 30.3 30 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.54501399687718e-05 0.000161167888739816 1.09811875127525 0.84 30.3 30 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.54501399687718e-05 0.000161167888739816 1.09811875127525 0.84 30.3 30 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.54501399687718e-05 0.000161167888739816 1.09811875127525 0.84 30.3 30 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 4.12880950094701e-06 2.31965892460793e-05 1.09643193291692 0.838709677419355 30.3 30 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4.88940637316517e-07 2.99897640905777e-06 1.09529219078291 0.837837837837838 30.3 30 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 5.85752239986624e-08 5.02123757530703e-07 1.09447051622118 0.837209302325581 30.3 30 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.37343501066213e-08 1.39599858583729e-07 1.08940352309053 0.833333333333333 30.3 30 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 6.92327634826491e-05 0.000300360434255517 1.08940352309053 0.833333333333333 30.3 30 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 6.92327634826491e-05 0.000300360434255517 1.08940352309053 0.833333333333333 30.3 30 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 6.92327634826491e-05 0.000300360434255517 1.08940352309053 0.833333333333333 30.3 30 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 6.92327634826491e-05 0.000300360434255517 1.08940352309053 0.833333333333333 30.3 30 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0006123493983538 0.00205512545721099 1.08940352309053 0.833333333333333 30.3 30 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0006123493983538 0.00205512545721099 1.08940352309053 0.833333333333333 30.3 30 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0006123493983538 0.00205512545721099 1.08940352309053 0.833333333333333 30.3 30 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00568130063146651 0.0143088332718174 1.08940352309053 0.833333333333333 30.3 30 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00568130063146651 0.0143088332718174 1.08940352309053 0.833333333333333 30.3 30 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.00568130063146651 0.0143088332718174 1.08940352309053 0.833333333333333 30.3 30 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00568130063146651 0.0143088332718174 1.08940352309053 0.833333333333333 30.3 30 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.00568130063146651 0.0143088332718174 1.08940352309053 0.833333333333333 30.3 30 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00568130063146651 0.0143088332718174 1.08940352309053 0.833333333333333 30.3 30 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00568130063146651 0.0143088332718174 1.08940352309053 0.833333333333333 30.3 30 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00568130063146651 0.0143088332718174 1.08940352309053 0.833333333333333 30.3 30 3 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_217410.1 ACTIVATION OF TRKA RECEPTORS 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604814 IRS ACTIVATION 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.0586013489414497 0.102570380742537 1.08940352309053 0.833333333333333 30.3 30 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.65507683917553e-08 2.50210221334224e-07 1.0847677634178 0.829787234042553 30.3 30 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.20036662234733e-07 1.52737644078061e-06 1.08408935956326 0.829268292682927 30.3 30 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.20036662234733e-07 1.52737644078061e-06 1.08408935956326 0.829268292682927 30.3 30 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 9.30219094393513e-11 1.71909320950905e-09 1.08259475107121 0.828125 30.3 30 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 7.58542690791167e-10 1.21281601010767e-08 1.08189039534507 0.827586206896552 30.3 30 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 7.58542690791167e-10 1.21281601010767e-08 1.08189039534507 0.827586206896552 30.3 30 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.55753028623689e-05 7.94396271439103e-05 1.08189039534507 0.827586206896552 30.3 30 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 6.21084624867732e-09 6.85118931152545e-08 1.08102349598983 0.826923076923077 30.3 30 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 6.21084624867732e-09 6.85118931152545e-08 1.08102349598983 0.826923076923077 30.3 30 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.11180044474585e-08 4.43542197126423e-07 1.0799304489767 0.826086956521739 30.3 30 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.78631664481573e-10 3.25888280201639e-09 1.07902825144204 0.825396825396825 30.3 30 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.52675212715291e-13 5.71728493931206e-12 1.07658701105417 0.823529411764706 30.3 30 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.54093766791323e-06 1.99950567517481e-05 1.07658701105417 0.823529411764706 30.3 30 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.19145640370551e-08 1.23754924268098e-07 1.07658701105417 0.823529411764706 30.3 30 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.19145640370551e-08 1.23754924268098e-07 1.07658701105417 0.823529411764706 30.3 30 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 9.7998063142242e-08 8.06076554054395e-07 1.07487814278265 0.822222222222222 30.3 30 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.99678175089369e-05 0.000139817063328581 1.0738406156178 0.821428571428571 30.3 30 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 2.99678175089369e-05 0.000139817063328581 1.0738406156178 0.821428571428571 30.3 30 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000258171680984259 0.000964247511917587 1.06959618630706 0.818181818181818 30.3 30 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000258171680984259 0.000964247511917587 1.06959618630706 0.818181818181818 30.3 30 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000258171680984259 0.000964247511917587 1.06959618630706 0.818181818181818 30.3 30 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0110760746724937 0.0250178639031088 1.06959618630706 0.818181818181818 30.3 30 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0110760746724937 0.0250178639031088 1.06959618630706 0.818181818181818 30.3 30 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0110760746724937 0.0250178639031088 1.06959618630706 0.818181818181818 30.3 30 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0110760746724937 0.0250178639031088 1.06959618630706 0.818181818181818 30.3 30 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0110760746724937 0.0250178639031088 1.06959618630706 0.818181818181818 30.3 30 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0110760746724937 0.0250178639031088 1.06959618630706 0.818181818181818 30.3 30 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0110760746724937 0.0250178639031088 1.06959618630706 0.818181818181818 30.3 30 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 6.77582357644163e-06 3.65227157169562e-05 1.06959618630706 0.818181818181818 30.3 30 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 4.33230394809201e-08 3.85304282383433e-07 1.06717079812949 0.816326530612245 30.3 30 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 5.72638355852197e-05 0.000252279993924977 1.06519455591074 0.814814814814815 30.3 30 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 5.72638355852197e-05 0.000252279993924977 1.06519455591074 0.814814814814815 30.3 30 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.28874370776737e-05 6.64450107301801e-05 1.06216843501326 0.8125 30.3 30 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00228663081598212 0.00648182400626006 1.06216843501326 0.8125 30.3 30 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00228663081598212 0.00648182400626006 1.06216843501326 0.8125 30.3 30 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00228663081598212 0.00648182400626006 1.06216843501326 0.8125 30.3 30 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00228663081598212 0.00648182400626006 1.06216843501326 0.8125 30.3 30 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000492272747734027 0.00171692186280765 1.05827770814508 0.80952380952381 30.3 30 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.54846334460428e-07 1.21069414251203e-06 1.05695320538145 0.808510638297872 30.3 30 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00010861310363352 0.000453244711057182 1.05588341468774 0.807692307692308 30.3 30 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00010861310363352 0.000453244711057182 1.05588341468774 0.807692307692308 30.3 30 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 3.68916601154531e-22 2.91649068579387e-20 1.05399790859008 0.80625 30.3 30 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 1.26307313921545e-06 7.39651472059089e-06 1.05220437839963 0.804878048780488 30.3 30 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.08357784985108e-28 2.96493128033808e-26 1.05205254515599 0.804761904761905 30.3 30 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 2.9072719333191e-07 1.97944878522157e-06 1.0515112266352 0.804347826086957 30.3 30 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 6.72582100002275e-08 5.69693052561451e-07 1.05095398698145 0.803921568627451 30.3 30 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 4.57035485984014e-05 0.000203875077290047 1.0458273821669 0.8 30.3 30 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 4.57035485984014e-05 0.000203875077290047 1.0458273821669 0.8 30.3 30 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000204363257538158 0.000782932376073212 1.0458273821669 0.8 30.3 30 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000204363257538158 0.000782932376073212 1.0458273821669 0.8 30.3 30 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000929732451074836 0.00294656854761579 1.0458273821669 0.8 30.3 30 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00434405962413092 0.0112392669911606 1.0458273821669 0.8 30.3 30 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00434405962413092 0.0112392669911606 1.0458273821669 0.8 30.3 30 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00434405962413092 0.0112392669911606 1.0458273821669 0.8 30.3 30 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00434405962413092 0.0112392669911606 1.0458273821669 0.8 30.3 30 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00434405962413092 0.0112392669911606 1.0458273821669 0.8 30.3 30 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00434405962413092 0.0112392669911606 1.0458273821669 0.8 30.3 30 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0212624506722475 0.0435972151392048 1.0458273821669 0.8 30.3 30 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.26053939919328e-08 1.29046587413816e-07 1.04139591020857 0.796610169491525 30.3 30 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.26053939919328e-08 1.29046587413816e-07 1.04139591020857 0.796610169491525 30.3 30 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 1.92532406521941e-05 9.57949700981546e-05 1.03813747494509 0.794117647058823 30.3 30 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 8.51391236541135e-05 0.000363082000357943 1.03681162887236 0.793103448275862 30.3 30 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.6908570673841e-17 3.37420400286982e-15 1.03577134964607 0.792307692307692 30.3 30 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 5.51498056732619e-10 9.12536900849438e-09 1.034933346936 0.791666666666667 30.3 30 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000381199785307885 0.00134602306325836 1.034933346936 0.791666666666667 30.3 30 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.000381199785307885 0.00134602306325836 1.034933346936 0.791666666666667 30.3 30 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000381199785307885 0.00134602306325836 1.034933346936 0.791666666666667 30.3 30 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.34977576868618e-09 3.1845056369909e-08 1.0341203592322 0.791044776119403 30.3 30 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.34977576868618e-09 3.1845056369909e-08 1.0341203592322 0.791044776119403 30.3 30 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.00318835954857e-08 1.06532614599822e-07 1.0331762444794 0.790322580645161 30.3 30 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00173755564181921 0.00505632245052912 1.03206649555945 0.789473684210526 30.3 30 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00173755564181921 0.00505632245052912 1.03206649555945 0.789473684210526 30.3 30 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00173755564181921 0.00505632245052912 1.03206649555945 0.789473684210526 30.3 30 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.93486371156396e-07 4.72439793370523e-06 1.02913864734509 0.787234042553192 30.3 30 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 4.36690020324486e-10 7.67172714718202e-09 1.02839692579746 0.786666666666667 30.3 30 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000157349235198258 0.000636800895963634 1.02715189319964 0.785714285714286 30.3 30 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000157349235198258 0.000636800895963634 1.02715189319964 0.785714285714286 30.3 30 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00814288093943273 0.0190580914092315 1.02715189319964 0.785714285714286 30.3 30 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00814288093943273 0.0190580914092315 1.02715189319964 0.785714285714286 30.3 30 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00814288093943273 0.0190580914092315 1.02715189319964 0.785714285714286 30.3 30 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00814288093943273 0.0190580914092315 1.02715189319964 0.785714285714286 30.3 30 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00814288093943273 0.0190580914092315 1.02715189319964 0.785714285714286 30.3 30 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00814288093943273 0.0190580914092315 1.02715189319964 0.785714285714286 30.3 30 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.07541812222195e-12 3.40071108427073e-11 1.02715189319964 0.785714285714286 30.3 30 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.38340040608244e-09 4.04586451920615e-08 1.02309200429371 0.782608695652174 30.3 30 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.45058240394276e-09 2.219547054635e-08 1.02075617779989 0.780821917808219 30.3 30 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.53610651710736e-12 4.5539157788412e-11 1.01968169761273 0.78 30.3 30 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 6.15204853849209e-07 3.70947672469248e-06 1.01968169761273 0.78 30.3 30 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.72228130406156e-05 0.000128013830120751 1.01677662155116 0.777777777777778 30.3 30 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 2.72228130406156e-05 0.000128013830120751 1.01677662155116 0.777777777777778 30.3 30 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00320961557651012 0.0086995866007122 1.01677662155116 0.777777777777778 30.3 30 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00320961557651012 0.0086995866007122 1.01677662155116 0.777777777777778 30.3 30 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00320961557651012 0.0086995866007122 1.01677662155116 0.777777777777778 30.3 30 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0400681532120215 0.0735702993815569 1.01677662155116 0.777777777777778 30.3 30 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0400681532120215 0.0735702993815569 1.01677662155116 0.777777777777778 30.3 30 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0400681532120215 0.0735702993815569 1.01677662155116 0.777777777777778 30.3 30 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0400681532120215 0.0735702993815569 1.01677662155116 0.777777777777778 30.3 30 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0400681532120215 0.0735702993815569 1.01677662155116 0.777777777777778 30.3 30 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0400681532120215 0.0735702993815569 1.01677662155116 0.777777777777778 30.3 30 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0400681532120215 0.0735702993815569 1.01677662155116 0.777777777777778 30.3 30 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0400681532120215 0.0735702993815569 1.01677662155116 0.777777777777778 30.3 30 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.1390212319018e-05 5.8939171381682e-05 1.01314527647419 0.775 30.3 30 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.02768084443979e-09 2.82881357023315e-08 1.01096646942801 0.773333333333333 30.3 30 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.02768084443979e-09 2.82881357023315e-08 1.01096646942801 0.773333333333333 30.3 30 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.02768084443979e-09 2.82881357023315e-08 1.01096646942801 0.773333333333333 30.3 30 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.02768084443979e-09 2.82881357023315e-08 1.01096646942801 0.773333333333333 30.3 30 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.02768084443979e-09 2.82881357023315e-08 1.01096646942801 0.773333333333333 30.3 30 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.98050980726729e-13 1.41606636393534e-11 1.01017417595667 0.772727272727273 30.3 30 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00128821637468324 0.00387554313144662 1.01017417595667 0.772727272727273 30.3 30 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00128821637468324 0.00387554313144662 1.01017417595667 0.772727272727273 30.3 30 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.45052471993082e-46 1.93902416911539e-43 1.00654748048927 0.769953051643192 30.3 30 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 8.48423970868907e-07 5.0304471272769e-06 1.00560325208356 0.769230769230769 30.3 30 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000523530437220285 0.001803834896282 1.00560325208356 0.769230769230769 30.3 30 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000523530437220285 0.001803834896282 1.00560325208356 0.769230769230769 30.3 30 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000523530437220285 0.001803834896282 1.00560325208356 0.769230769230769 30.3 30 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0150314787110671 0.0325072860271253 1.00560325208356 0.769230769230769 30.3 30 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0150314787110671 0.0325072860271253 1.00560325208356 0.769230769230769 30.3 30 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0150314787110671 0.0325072860271253 1.00560325208356 0.769230769230769 30.3 30 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0150314787110671 0.0325072860271253 1.00560325208356 0.769230769230769 30.3 30 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.27654870880975e-12 3.87829765816956e-11 1.00467213796126 0.768518518518518 30.3 30 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.24119001004235e-11 3.15395247194691e-10 1.00357173036218 0.767676767676768 30.3 30 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.24119001004235e-11 3.15395247194691e-10 1.00357173036218 0.767676767676768 30.3 30 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 8.59630179152122e-06 4.53056942567952e-05 1.00326463986941 0.767441860465116 30.3 30 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 6.51279063303789e-09 7.12900082370224e-08 1.00284817468059 0.767123287671233 30.3 30 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.7905654786878e-24 2.64731645078182e-22 1.00244664994698 0.766816143497758 30.3 30 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00585224207238344 0.014533578479933 0.999687938836012 0.764705882352941 30.3 30 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00585224207238344 0.014533578479933 0.999687938836012 0.764705882352941 30.3 30 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00585224207238344 0.014533578479933 0.999687938836012 0.764705882352941 30.3 30 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00585224207238344 0.014533578479933 0.999687938836012 0.764705882352941 30.3 30 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00585224207238344 0.014533578479933 0.999687938836012 0.764705882352941 30.3 30 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00585224207238344 0.014533578479933 0.999687938836012 0.764705882352941 30.3 30 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.42520259895515e-13 2.57708860934468e-11 0.997664279040797 0.763157894736842 30.3 30 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.68233054729142e-05 0.00016687759136292 0.997664279040797 0.763157894736842 30.3 30 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.59999282860196e-15 1.19348057906471e-13 0.9969217851591 0.762589928057554 30.3 30 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.19643326454291e-23 1.06407783465285e-21 0.996584388836176 0.762331838565022 30.3 30 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00232960350176542 0.00656440749111326 0.996026078254195 0.761904761904762 30.3 30 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00232960350176542 0.00656440749111326 0.996026078254195 0.761904761904762 30.3 30 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00232960350176542 0.00656440749111326 0.996026078254195 0.761904761904762 30.3 30 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.85147279264175e-08 4.23536551161301e-07 0.995096949449853 0.761194029850746 30.3 30 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.85147279264175e-08 4.23536551161301e-07 0.995096949449853 0.761194029850746 30.3 30 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.42659346671981e-53 1.1510141677141e-50 0.994132492554092 0.760456273764259 30.3 30 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.000941182123245348 0.00296305787915515 0.993536013058559 0.76 30.3 30 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.000941182123245348 0.00296305787915515 0.993536013058559 0.76 30.3 30 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000941182123245348 0.00296305787915515 0.993536013058559 0.76 30.3 30 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.72171675232396e-09 4.37686193269173e-08 0.992874096993897 0.759493670886076 30.3 30 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.72171675232396e-09 4.37686193269173e-08 0.992874096993897 0.759493670886076 30.3 30 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.91230341538543e-27 9.38267313341123e-25 0.991732862399651 0.758620689655172 30.3 30 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 9.0097681301813e-30 1.42454444991644e-27 0.990502042837256 0.757679180887372 30.3 30 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 9.57306778218173e-12 2.52268063963789e-10 0.989626377985038 0.757009345794392 30.3 30 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.72580397235332e-05 0.000128013830120751 0.988434416072379 0.75609756097561 30.3 30 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.72580397235332e-05 0.000128013830120751 0.988434416072379 0.75609756097561 30.3 30 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.72580397235332e-05 0.000128013830120751 0.988434416072379 0.75609756097561 30.3 30 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.72580397235332e-05 0.000128013830120751 0.988434416072379 0.75609756097561 30.3 30 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.00736791549876e-06 1.16117257876209e-05 0.986629605817835 0.754716981132076 30.3 30 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.51106837944461e-07 1.18798359334236e-06 0.985491187041891 0.753846153846154 30.3 30 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 4.49330086349881e-27 5.81269738978074e-25 0.985269362795108 0.753676470588235 30.3 30 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.79095709278405e-10 6.74316492878963e-09 0.983977375694669 0.752688172043011 30.3 30 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.00436951599508e-05 9.76786925089384e-05 0.980463170781473 0.75 30.3 30 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.00436951599508e-05 9.76786925089384e-05 0.980463170781473 0.75 30.3 30 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000681294461615509 0.00226514490392259 0.980463170781473 0.75 30.3 30 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.12139458535975e-07 9.01550562128205e-07 0.980463170781473 0.75 30.3 30 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00011560414457839 0.000479605532755245 0.980463170781473 0.75 30.3 30 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000279707130121558 0.00103651887021609 0.980463170781473 0.75 30.3 30 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0105163460485773 0.0240204822265258 0.980463170781473 0.75 30.3 30 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0105163460485773 0.0240204822265258 0.980463170781473 0.75 30.3 30 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0105163460485773 0.0240204822265258 0.980463170781473 0.75 30.3 30 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0105163460485773 0.0240204822265258 0.980463170781473 0.75 30.3 30 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0105163460485773 0.0240204822265258 0.980463170781473 0.75 30.3 30 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0105163460485773 0.0240204822265258 0.980463170781473 0.75 30.3 30 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0105163460485773 0.0240204822265258 0.980463170781473 0.75 30.3 30 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0105163460485773 0.0240204822265258 0.980463170781473 0.75 30.3 30 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0738208299597709 0.125804839560184 0.980463170781473 0.75 30.3 30 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0738208299597709 0.125804839560184 0.980463170781473 0.75 30.3 30 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0738208299597709 0.125804839560184 0.980463170781473 0.75 30.3 30 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0738208299597709 0.125804839560184 0.980463170781473 0.75 30.3 30 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0738208299597709 0.125804839560184 0.980463170781473 0.75 30.3 30 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0738208299597709 0.125804839560184 0.980463170781473 0.75 30.3 30 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 5.14919976070772e-11 1.00374126842289e-09 0.980463170781473 0.75 30.3 30 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 8.39365509143541e-06 4.44021234019055e-05 0.980463170781473 0.75 30.3 30 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 8.39365509143541e-06 4.44021234019055e-05 0.980463170781473 0.75 30.3 30 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.80333980189152e-05 0.000213598516815363 0.980463170781473 0.75 30.3 30 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00416102521405234 0.0108844464698465 0.980463170781473 0.75 30.3 30 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00416102521405234 0.0108844464698465 0.980463170781473 0.75 30.3 30 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00416102521405234 0.0108844464698465 0.980463170781473 0.75 30.3 30 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00416102521405234 0.0108844464698465 0.980463170781473 0.75 30.3 30 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00416102521405234 0.0108844464698465 0.980463170781473 0.75 30.3 30 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00416102521405234 0.0108844464698465 0.980463170781473 0.75 30.3 30 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0272603967955752 0.0543298944539266 0.980463170781473 0.75 30.3 30 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0272603967955752 0.0543298944539266 0.980463170781473 0.75 30.3 30 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0272603967955752 0.0543298944539266 0.980463170781473 0.75 30.3 30 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0272603967955752 0.0543298944539266 0.980463170781473 0.75 30.3 30 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.28095565659852e-12 3.87829765816956e-11 0.977806089017838 0.747967479674797 30.3 30 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 4.9220375455671e-10 8.3912748161007e-09 0.977022949129608 0.747368421052632 30.3 30 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 8.28937433526384e-08 6.93869392887085e-07 0.975860057303626 0.746478873239437 30.3 30 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 8.98909220081897e-25 9.13677014411814e-23 0.975435154521055 0.746153846153846 30.3 30 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 1.09282081263226e-06 6.45263077334318e-06 0.974923830833555 0.745762711864407 30.3 30 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.00341528537319e-09 2.82881357023315e-08 0.973200480627536 0.744444444444444 30.3 30 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 4.70124272234682e-09 5.39505515637058e-08 0.972862681085493 0.744186046511628 30.3 30 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.59527447635116e-08 2.46205038656513e-07 0.972083143680777 0.743589743589744 30.3 30 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.49902771223424e-17 9.27441928047532e-16 0.971533633706961 0.743169398907104 30.3 30 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 4.91981539037171e-11 9.72346847291521e-10 0.971468095820175 0.743119266055046 30.3 30 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000202371645166235 0.000782932376073212 0.97112542629784 0.742857142857143 30.3 30 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000202371645166235 0.000782932376073212 0.97112542629784 0.742857142857143 30.3 30 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000202371645166235 0.000782932376073212 0.97112542629784 0.742857142857143 30.3 30 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000202371645166235 0.000782932376073212 0.97112542629784 0.742857142857143 30.3 30 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.84853935447182e-12 7.79513750271808e-11 0.969920556041887 0.741935483870968 30.3 30 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.84853935447182e-12 7.79513750271808e-11 0.969920556041887 0.741935483870968 30.3 30 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.84853935447182e-12 7.79513750271808e-11 0.969920556041887 0.741935483870968 30.3 30 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.000490164060687728 0.00171376771095488 0.969920556041887 0.741935483870968 30.3 30 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 3.27168498404632e-16 1.86224309291916e-14 0.96892830994875 0.741176470588235 30.3 30 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 8.12859020252697e-09 8.69698034450818e-08 0.96892830994875 0.741176470588235 30.3 30 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 8.12859020252697e-09 8.69698034450818e-08 0.96892830994875 0.741176470588235 30.3 30 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 8.12859020252697e-09 8.69698034450818e-08 0.96892830994875 0.741176470588235 30.3 30 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00119551585269947 0.00368229233418039 0.968358687191579 0.740740740740741 30.3 30 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00119551585269947 0.00368229233418039 0.968358687191579 0.740740740740741 30.3 30 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00119551585269947 0.00368229233418039 0.968358687191579 0.740740740740741 30.3 30 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00119551585269947 0.00368229233418039 0.968358687191579 0.740740740740741 30.3 30 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00119551585269947 0.00368229233418039 0.968358687191579 0.740740740740741 30.3 30 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00119551585269947 0.00368229233418039 0.968358687191579 0.740740740740741 30.3 30 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00119551585269947 0.00368229233418039 0.968358687191579 0.740740740740741 30.3 30 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.90857492076396e-08 1.86020692619665e-07 0.968358687191578 0.740740740740741 30.3 30 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.90857492076396e-08 1.86020692619665e-07 0.968358687191578 0.740740740740741 30.3 30 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.90857492076396e-08 1.86020692619665e-07 0.968358687191578 0.740740740740741 30.3 30 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.06806854982518e-05 5.54693995036947e-05 0.967390328504387 0.74 30.3 30 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 5.63040702869563e-16 3.08156507762842e-14 0.966926203926502 0.739644970414201 30.3 30 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.48477928346948e-07 1.70813571032709e-06 0.966253559610727 0.739130434782609 30.3 30 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.54421584431716e-05 0.000121899634561054 0.966253559610727 0.739130434782609 30.3 30 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.54421584431716e-05 0.000121899634561054 0.966253559610727 0.739130434782609 30.3 30 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00294242930302589 0.00803661592745843 0.966253559610727 0.739130434782609 30.3 30 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00294242930302589 0.00803661592745843 0.966253559610727 0.739130434782609 30.3 30 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.96947403364561e-09 6.74171551577595e-08 0.965607668193875 0.738636363636364 30.3 30 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.85905946134893e-07 3.54784749510618e-06 0.96537912200022 0.738461538461539 30.3 30 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.86840262866589e-09 2.76951764644955e-08 0.963262062522149 0.736842105263158 30.3 30 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.86840262866589e-09 2.76951764644955e-08 0.963262062522149 0.736842105263158 30.3 30 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00733138339364467 0.0174166253241342 0.963262062522149 0.736842105263158 30.3 30 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00733138339364467 0.0174166253241342 0.963262062522149 0.736842105263158 30.3 30 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00733138339364467 0.0174166253241342 0.963262062522149 0.736842105263158 30.3 30 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.65597501499644e-12 7.71316825783659e-11 0.962728694824186 0.736434108527132 30.3 30 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.85730568812246e-15 1.71529562318696e-13 0.962417836349912 0.736196319018405 30.3 30 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.81476297328746e-07 1.27841965890498e-06 0.962306445396631 0.736111111111111 30.3 30 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.02457779007621e-08 1.07998088539145e-07 0.961680351417843 0.735632183908046 30.3 30 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.44411686260577e-11 3.48301406014916e-10 0.961556167488167 0.735537190082645 30.3 30 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.44411686260577e-11 3.48301406014916e-10 0.961556167488167 0.735537190082645 30.3 30 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000351189233224084 0.00125248691448088 0.961238402726935 0.735294117647059 30.3 30 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000351189233224084 0.00125248691448088 0.961238402726935 0.735294117647059 30.3 30 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.15545318965033e-32 2.34887126981775e-30 0.961238402726934 0.735294117647059 30.3 30 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.40151994626503e-08 2.29353213660076e-07 0.960775155303934 0.734939759036145 30.3 30 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 1.84150471502788e-05 9.22697608973478e-05 0.960453718316545 0.73469387755102 30.3 30 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 5.63296759690299e-08 4.85800781235937e-07 0.959778293760767 0.734177215189873 30.3 30 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0185896395565127 0.0389588469645326 0.958675100319663 0.733333333333333 30.3 30 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0185896395565127 0.0389588469645326 0.958675100319663 0.733333333333333 30.3 30 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0185896395565127 0.0389588469645326 0.958675100319663 0.733333333333333 30.3 30 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0185896395565127 0.0389588469645326 0.958675100319663 0.733333333333333 30.3 30 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.7516541996064e-08 1.74307966855937e-07 0.957661701693532 0.732558139534884 30.3 30 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 4.10263530011426e-08 3.67172957991358e-07 0.956549434908754 0.731707317073171 30.3 30 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 4.10263530011426e-08 3.67172957991358e-07 0.956549434908754 0.731707317073171 30.3 30 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000104693466097231 0.000440765687148993 0.956549434908754 0.731707317073171 30.3 30 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 7.29243658520449e-10 1.1927743977869e-08 0.955323089479384 0.730769230769231 30.3 30 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.32930301617867e-05 6.82887433943051e-05 0.955323089479384 0.730769230769231 30.3 30 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00207480812817053 0.00592861840639891 0.955323089479384 0.730769230769231 30.3 30 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.27991154965483e-10 4.1067267533656e-09 0.953964166165758 0.72972972972973 30.3 30 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 2.98264865717298e-08 2.75604483062153e-07 0.953548495505119 0.729411764705882 30.3 30 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 2.98264865717298e-08 2.75604483062153e-07 0.953548495505119 0.729411764705882 30.3 30 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 3.15382335878481e-05 0.000146663092795777 0.95322808270421 0.729166666666667 30.3 30 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.3853114497175e-15 7.30110441832594e-14 0.952766471041884 0.728813559322034 30.3 30 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00510663584065125 0.0130696812972064 0.950752165606277 0.727272727272727 30.3 30 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00510663584065125 0.0130696812972064 0.950752165606277 0.727272727272727 30.3 30 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0484261200049242 0.0870080413724837 0.950752165606277 0.727272727272727 30.3 30 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.9983717779952e-12 1.87899680001645e-10 0.950752165606277 0.727272727272727 30.3 30 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.000603822449707838 0.0020409485651645 0.950752165606277 0.727272727272727 30.3 30 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 2.26409629076306e-05 0.000109585340876049 0.948421890690575 0.725490196078431 30.3 30 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000178868190629358 0.000703119986921482 0.947781065088757 0.725 30.3 30 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.74364820876422e-11 6.0749697105021e-10 0.947009046844048 0.724409448818898 30.3 30 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 3.66022977462312e-08 3.31752036260427e-07 0.94665409592694 0.724137931034483 30.3 30 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 3.66022977462312e-08 3.31752036260427e-07 0.94665409592694 0.724137931034483 30.3 30 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0014609172607216 0.00435825002517158 0.94665409592694 0.724137931034483 30.3 30 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0014609172607216 0.00435825002517158 0.94665409592694 0.724137931034483 30.3 30 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.21256180032534e-17 7.84307019028616e-16 0.946224774341485 0.723809523809524 30.3 30 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.14038364484596e-13 4.3858538557184e-12 0.945520038908758 0.723270440251572 30.3 30 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.52287743504643e-15 7.73948067882523e-14 0.944939142854608 0.722826086956522 30.3 30 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.62275001828771e-05 8.24704741436934e-05 0.944149720011789 0.722222222222222 30.3 30 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00042796714669463 0.00150369691295422 0.944149720011789 0.722222222222222 30.3 30 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0127230709616541 0.0284221820697547 0.944149720011789 0.722222222222222 30.3 30 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0127230709616541 0.0284221820697547 0.944149720011789 0.722222222222222 30.3 30 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0127230709616541 0.0284221820697547 0.944149720011789 0.722222222222222 30.3 30 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.55662835110351e-15 1.19348057906471e-13 0.942959115068521 0.721311475409836 30.3 30 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 6.16271767255328e-08 5.25122589703192e-07 0.942460722301571 0.720930232558139 30.3 30 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.9318594717708e-09 6.74171551577595e-08 0.941244643950214 0.72 30.3 30 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00355805566365793 0.00946376300819669 0.941244643950214 0.72 30.3 30 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.20997185504853e-13 1.1712281922395e-11 0.940911577904938 0.719745222929936 30.3 30 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 4.44229919476655e-08 3.92633028208248e-07 0.940069557003959 0.719101123595506 30.3 30 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 9.43903220822444e-18 6.39606801538256e-16 0.938867763536199 0.718181818181818 30.3 30 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.03320787494728e-07 8.40145603457129e-07 0.938168681061488 0.717647058823529 30.3 30 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 7.42839657697887e-08 6.25479782783487e-07 0.935896663018679 0.715909090909091 30.3 30 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.2233834803309e-09 3.07172300243774e-08 0.935487795974984 0.715596330275229 30.3 30 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00248106933040937 0.00696363245990637 0.933774448363308 0.714285714285714 30.3 30 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.032252973140153 0.061605343326762 0.933774448363308 0.714285714285714 30.3 30 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.032252973140153 0.061605343326762 0.933774448363308 0.714285714285714 30.3 30 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.032252973140153 0.061605343326762 0.933774448363308 0.714285714285714 30.3 30 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.032252973140153 0.061605343326762 0.933774448363308 0.714285714285714 30.3 30 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.032252973140153 0.061605343326762 0.933774448363308 0.714285714285714 30.3 30 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.032252973140153 0.061605343326762 0.933774448363308 0.714285714285714 30.3 30 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.132234684799375 0.202551083390216 0.933774448363308 0.714285714285714 30.3 30 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.000214448692954264 0.000818124638267875 0.933774448363308 0.714285714285714 30.3 30 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00873957949476967 0.0203209503612046 0.933774448363308 0.714285714285714 30.3 30 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 2.86599717411251e-07 1.96072787440485e-06 0.92927433053987 0.710843373493976 30.3 30 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000508864080304427 0.00176613069822732 0.928859846003501 0.710526315789474 30.3 30 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 6.12809842275708e-09 6.85118931152545e-08 0.928538329961271 0.710280373831776 30.3 30 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00173182474983713 0.00505632245052912 0.927750097083545 0.709677419354839 30.3 30 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.15597393294151e-06 1.23210879782159e-05 0.925992994626947 0.708333333333333 30.3 30 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.05707028721645e-14 4.4241500550265e-13 0.925992994626947 0.708333333333333 30.3 30 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000107303634051257 0.000450422039100116 0.925992994626947 0.708333333333333 30.3 30 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0060231270178695 0.0148983609011789 0.925992994626947 0.708333333333333 30.3 30 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0060231270178695 0.0148983609011789 0.925992994626947 0.708333333333333 30.3 30 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.04822223016784e-07 8.47511496323204e-07 0.923624726098489 0.706521739130435 30.3 30 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.6180241871259e-09 2.44941321093634e-08 0.922788866617857 0.705882352941177 30.3 30 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.38417627715852e-07 2.12605192320729e-06 0.922788866617857 0.705882352941177 30.3 30 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.38417627715852e-07 2.12605192320729e-06 0.922788866617857 0.705882352941177 30.3 30 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.38417627715852e-07 2.12605192320729e-06 0.922788866617857 0.705882352941177 30.3 30 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.38417627715852e-07 2.12605192320729e-06 0.922788866617857 0.705882352941177 30.3 30 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.38417627715852e-07 2.12605192320729e-06 0.922788866617857 0.705882352941177 30.3 30 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00121014216926885 0.00371929223945912 0.922788866617857 0.705882352941177 30.3 30 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0217101955914427 0.0441968645588311 0.922788866617857 0.705882352941177 30.3 30 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0217101955914427 0.0441968645588311 0.922788866617857 0.705882352941177 30.3 30 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0217101955914427 0.0441968645588311 0.922788866617857 0.705882352941177 30.3 30 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0217101955914427 0.0441968645588311 0.922788866617857 0.705882352941177 30.3 30 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 8.11979993540748e-11 1.52032569843222e-09 0.921682405147092 0.705035971223022 30.3 30 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.30683899648451e-11 3.26251209122362e-10 0.920259291873839 0.703947368421053 30.3 30 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 7.80472897600669e-07 4.66644089615862e-06 0.919940752831999 0.703703703703704 30.3 30 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000846514195998843 0.0026948315456518 0.91863216001147 0.702702702702703 30.3 30 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000846514195998843 0.0026948315456518 0.91863216001147 0.702702702702703 30.3 30 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000846514195998843 0.0026948315456518 0.91863216001147 0.702702702702703 30.3 30 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.95708149381575e-60 6.37296348284991e-57 0.916873553370307 0.701357466063348 30.3 30 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 4.53840645475344e-15 1.95701587427701e-13 0.915098959396042 0.7 30.3 30 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000592762311102677 0.00200833516356931 0.915098959396042 0.7 30.3 30 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000592762311102677 0.00200833516356931 0.915098959396042 0.7 30.3 30 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000592762311102677 0.00200833516356931 0.915098959396042 0.7 30.3 30 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.00288488307782847 0.00790980466233125 0.915098959396042 0.7 30.3 30 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00288488307782847 0.00790980466233125 0.915098959396042 0.7 30.3 30 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0147288858126935 0.0320477133202795 0.915098959396042 0.7 30.3 30 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0147288858126935 0.0320477133202795 0.915098959396042 0.7 30.3 30 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0147288858126935 0.0320477133202795 0.915098959396042 0.7 30.3 30 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0147288858126935 0.0320477133202795 0.915098959396042 0.7 30.3 30 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0147288858126935 0.0320477133202795 0.915098959396042 0.7 30.3 30 3 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.0839481258048276 0.137308256345137 0.915098959396042 0.7 30.3 30 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0839481258048276 0.137308256345137 0.915098959396042 0.7 30.3 30 3 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.0839481258048276 0.137308256345137 0.915098959396042 0.7 30.3 30 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0839481258048276 0.137308256345137 0.915098959396042 0.7 30.3 30 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0839481258048276 0.137308256345137 0.915098959396042 0.7 30.3 30 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0839481258048276 0.137308256345137 0.915098959396042 0.7 30.3 30 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0839481258048276 0.137308256345137 0.915098959396042 0.7 30.3 30 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0839481258048276 0.137308256345137 0.915098959396042 0.7 30.3 30 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.95338780430399e-10 8.3912748161007e-09 0.91411603892408 0.699248120300752 30.3 30 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.78244952934923e-11 4.22737613377327e-10 0.913422953975902 0.698717948717949 30.3 30 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.1405015238961e-06 2.31965892460793e-05 0.913308159084112 0.698630136986301 30.3 30 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00200360321371617 0.00573667479500624 0.911137492039349 0.696969696969697 30.3 30 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00200360321371617 0.00573667479500624 0.911137492039349 0.696969696969697 30.3 30 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00200360321371617 0.00573667479500624 0.911137492039349 0.696969696969697 30.3 30 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.08441866963652e-06 1.19601926084386e-05 0.910134588911072 0.69620253164557 30.3 30 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000291488299747007 0.00107457992367873 0.909415114927743 0.695652173913043 30.3 30 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000291488299747007 0.00107457992367873 0.909415114927743 0.695652173913043 30.3 30 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0100533936409378 0.0232996403111637 0.909415114927743 0.695652173913043 30.3 30 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.74071617063986e-06 3.6471631600078e-05 0.907836269242105 0.694444444444444 30.3 30 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.74071617063986e-06 3.6471631600078e-05 0.907836269242105 0.694444444444444 30.3 30 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000204673818622091 0.000782932376073212 0.90709517841007 0.693877551020408 30.3 30 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.38584835857386e-11 5.4759067971784e-10 0.906928432972863 0.69375 30.3 30 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.95699352223812e-09 3.96962432277816e-08 0.905834740459524 0.692913385826772 30.3 30 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 4.72351705528883e-10 8.19703020692195e-09 0.905761214912409 0.692857142857143 30.3 30 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00689536261850455 0.0165465446983676 0.905042926875206 0.692307692307692 30.3 30 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00689536261850455 0.0165465446983676 0.905042926875206 0.692307692307692 30.3 30 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00689536261850455 0.0165465446983676 0.905042926875206 0.692307692307692 30.3 30 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0547754624857187 0.0974318538964721 0.905042926875206 0.692307692307692 30.3 30 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0547754624857187 0.0974318538964721 0.905042926875206 0.692307692307692 30.3 30 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0547754624857187 0.0974318538964721 0.905042926875206 0.692307692307692 30.3 30 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0547754624857187 0.0974318538964721 0.905042926875206 0.692307692307692 30.3 30 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0547754624857187 0.0974318538964721 0.905042926875206 0.692307692307692 30.3 30 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000101148056408612 0.000427102920680874 0.903214557325963 0.690909090909091 30.3 30 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000678629726982335 0.00226156932434628 0.902648633417864 0.69047619047619 30.3 30 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000678629726982335 0.00226156932434628 0.902648633417864 0.69047619047619 30.3 30 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.89107688343205e-07 1.32561694833685e-06 0.902026117118955 0.69 30.3 30 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00474807392971553 0.0122400529021471 0.901575329454228 0.689655172413793 30.3 30 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 7.71289486526273e-06 4.12610879446198e-05 0.900966156934327 0.689189189189189 30.3 30 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 7.71289486526273e-06 4.12610879446198e-05 0.900966156934327 0.689189189189189 30.3 30 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 3.13877513003088e-11 6.29081269018866e-10 0.90075071787241 0.689024390243902 30.3 30 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000474475168763058 0.00166300040677298 0.900573579088168 0.688888888888889 30.3 30 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000332151103207463 0.00121192569195954 0.898757906549684 0.6875 30.3 30 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.003280242634116 0.0087769217070812 0.898757906549684 0.6875 30.3 30 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0363508852739706 0.0678836085890552 0.898757906549684 0.6875 30.3 30 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0363508852739706 0.0678836085890552 0.898757906549684 0.6875 30.3 30 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0363508852739706 0.0678836085890552 0.898757906549684 0.6875 30.3 30 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0363508852739706 0.0678836085890552 0.898757906549684 0.6875 30.3 30 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 2.48983926071666e-05 0.000120103093830502 0.897538424993985 0.686567164179104 30.3 30 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.38989355807111e-09 2.17342695948921e-08 0.896423470428775 0.685714285714286 30.3 30 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.75620839697003e-05 8.86200194641262e-05 0.896423470428775 0.685714285714286 30.3 30 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.000114670715844645 0.000477124060371139 0.894457629484853 0.684210526315789 30.3 30 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 8.74975947180763e-06 4.59443089608202e-05 0.894457629484853 0.684210526315789 30.3 30 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00157808944667009 0.00464931942569675 0.894457629484853 0.684210526315789 30.3 30 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 6.17994725748007e-06 3.39539187158075e-05 0.893586687294507 0.683544303797468 30.3 30 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.95096126219421e-08 1.88858358918527e-07 0.892779472581504 0.682926829268293 30.3 30 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 5.66796840622017e-05 0.000251262275453312 0.892273361769383 0.682539682539683 30.3 30 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.22504078446529e-07 9.79344402412421e-07 0.891330155255885 0.681818181818182 30.3 30 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000765533993660247 0.0024646037850193 0.891330155255885 0.681818181818182 30.3 30 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.97988018426883e-05 9.71506724901569e-05 0.889679543857263 0.680555555555556 30.3 30 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.90791262236567e-06 2.7069611091575e-05 0.887085725945142 0.678571428571429 30.3 30 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.90791262236567e-06 2.7069611091575e-05 0.887085725945142 0.678571428571429 30.3 30 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0077141385144247 0.0182345832326019 0.887085725945142 0.678571428571429 30.3 30 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.49017730400544e-30 2.65065287949967e-28 0.886211405300607 0.677902621722846 30.3 30 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 9.0354861362841e-05 0.000383805873789023 0.885579638125202 0.67741935483871 30.3 30 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.07689551513131e-10 8.49932037415512e-09 0.885312736486225 0.677215189873418 30.3 30 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00366265812483329 0.00970570300118765 0.88433933050878 0.676470588235294 30.3 30 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00366265812483329 0.00970570300118765 0.88433933050878 0.676470588235294 30.3 30 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00253549706284012 0.00710238645752263 0.883300153857183 0.675675675675676 30.3 30 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00122372254859584 0.0037459256712635 0.881656804733728 0.674418604651163 30.3 30 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000852648031396233 0.0027082994390108 0.880995892586251 0.673913043478261 30.3 30 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 3.42140471127526e-07 2.12605192320729e-06 0.879445753185806 0.672727272727273 30.3 30 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000203939025814338 0.000782932376073212 0.879035946217872 0.672413793103448 30.3 30 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000143039848951646 0.000591702630983118 0.878666448132031 0.672131147540984 30.3 30 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.06531738070363e-11 4.81794529957585e-10 0.878331590491736 0.671875 30.3 30 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 9.53811910570287e-08 7.89112993454371e-07 0.875037023385616 0.669354838709677 30.3 30 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 7.07545911493085e-11 1.34245044273955e-09 0.873853093388122 0.668449197860963 30.3 30 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 7.78128302234742e-05 0.000336558229203659 0.871522818472421 0.666666666666667 30.3 30 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00583352147491568 0.014533578479933 0.871522818472421 0.666666666666667 30.3 30 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00583352147491568 0.014533578479933 0.871522818472421 0.666666666666667 30.3 30 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.012359833290685 0.0277852176503078 0.871522818472421 0.666666666666667 30.3 30 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.012359833290685 0.0277852176503078 0.871522818472421 0.666666666666667 30.3 30 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.012359833290685 0.0277852176503078 0.871522818472421 0.666666666666667 30.3 30 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0267074984485411 0.0535278454820761 0.871522818472421 0.666666666666667 30.3 30 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0267074984485411 0.0535278454820761 0.871522818472421 0.666666666666667 30.3 30 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0267074984485411 0.0535278454820761 0.871522818472421 0.666666666666667 30.3 30 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0396844448510198 0.0735702993815569 0.871522818472421 0.666666666666667 30.3 30 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0396844448510198 0.0735702993815569 0.871522818472421 0.666666666666667 30.3 30 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0396844448510198 0.0735702993815569 0.871522818472421 0.666666666666667 30.3 30 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0396844448510198 0.0735702993815569 0.871522818472421 0.666666666666667 30.3 30 3 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.141326183455269 0.214858075915436 0.871522818472421 0.666666666666667 30.3 30 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.141326183455269 0.214858075915436 0.871522818472421 0.666666666666667 30.3 30 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.141326183455269 0.214858075915436 0.871522818472421 0.666666666666667 30.3 30 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.141326183455269 0.214858075915436 0.871522818472421 0.666666666666667 30.3 30 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.141326183455269 0.214858075915436 0.871522818472421 0.666666666666667 30.3 30 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.141326183455269 0.214858075915436 0.871522818472421 0.666666666666667 30.3 30 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.141326183455269 0.214858075915436 0.871522818472421 0.666666666666667 30.3 30 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.000157705215964119 0.000636800895963634 0.871522818472421 0.666666666666667 30.3 30 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000224819169851365 0.000855394862830193 0.871522818472421 0.666666666666667 30.3 30 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00847445563348956 0.0197367436439536 0.871522818472421 0.666666666666667 30.3 30 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.00847445563348956 0.0197367436439536 0.871522818472421 0.666666666666667 30.3 30 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0181139268870745 0.0381868414226771 0.871522818472421 0.666666666666667 30.3 30 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0181139268870745 0.0381868414226771 0.871522818472421 0.666666666666667 30.3 30 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0181139268870745 0.0381868414226771 0.871522818472421 0.666666666666667 30.3 30 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0595796403074334 0.103772127487733 0.871522818472421 0.666666666666667 30.3 30 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0595796403074334 0.103772127487733 0.871522818472421 0.666666666666667 30.3 30 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0595796403074334 0.103772127487733 0.871522818472421 0.666666666666667 30.3 30 3 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0907575664236218 0.147935872876075 0.871522818472421 0.666666666666667 30.3 30 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0907575664236218 0.147935872876075 0.871522818472421 0.666666666666667 30.3 30 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.30593832744844e-07 1.59288846599958e-06 0.867951003642616 0.663934426229508 30.3 30 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 8.52209333236492e-05 0.000363082000357943 0.865385333835291 0.661971830985915 30.3 30 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 3.56445142362688e-07 2.20531059818307e-06 0.864320150551161 0.661157024793388 30.3 30 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000350722739725348 0.00125248691448088 0.864137031875197 0.661016949152542 30.3 30 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.40806073262499e-38 6.85334084505072e-36 0.863711474388801 0.660691421254802 30.3 30 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 6.52903011017846e-05 0.000286753390332838 0.860055412966204 0.657894736842105 30.3 30 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00632714893984027 0.0155770466114061 0.859072492494243 0.657142857142857 30.3 30 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.000267065392898303 0.000994853544749438 0.857905274433789 0.65625 30.3 30 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 1.75091508748464e-05 8.86200194641262e-05 0.856997438164547 0.655555555555556 30.3 30 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.02963235763162e-12 3.32992464752226e-11 0.855959910999699 0.654761904761905 30.3 30 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.02963235763162e-12 3.32992464752226e-11 0.855959910999699 0.654761904761905 30.3 30 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.02963235763162e-12 3.32992464752226e-11 0.855959910999699 0.654761904761905 30.3 30 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00077530287155685 0.00248481077978693 0.855676949045649 0.654545454545455 30.3 30 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00077530287155685 0.00248481077978693 0.855676949045649 0.654545454545455 30.3 30 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0195083700300241 0.0405853955449185 0.854762764271028 0.653846153846154 30.3 30 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0195083700300241 0.0405853955449185 0.854762764271028 0.653846153846154 30.3 30 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0195083700300241 0.0405853955449185 0.854762764271028 0.653846153846154 30.3 30 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00158711147341672 0.00466623889808263 0.853736638503596 0.653061224489796 30.3 30 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0286577058398266 0.0569747593040547 0.852576670244759 0.652173913043478 30.3 30 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000202619347971653 0.000782932376073212 0.852576670244759 0.652173913043478 30.3 30 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.000202619347971653 0.000782932376073212 0.852576670244759 0.652173913043478 30.3 30 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000410265913765815 0.0014450702853682 0.850772275175458 0.650793650793651 30.3 30 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.47397919784276e-20 1.10393284133171e-18 0.85002786106615 0.650224215246637 30.3 30 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0423750997545436 0.0777058852457675 0.84973474801061 0.65 30.3 30 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 5.31767514032584e-07 3.23378278832636e-06 0.848237857673539 0.648854961832061 30.3 30 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 5.31767514032584e-07 3.23378278832636e-06 0.848237857673539 0.648854961832061 30.3 30 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00119022704649068 0.00368229233418039 0.847313851292631 0.648148148148148 30.3 30 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.0631921496919385 0.109129161421879 0.845889794399702 0.647058823529412 30.3 30 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0631921496919385 0.109129161421879 0.845889794399702 0.647058823529412 30.3 30 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0631921496919385 0.109129161421879 0.845889794399702 0.647058823529412 30.3 30 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0631921496919385 0.109129161421879 0.845889794399702 0.647058823529412 30.3 30 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0631921496919385 0.109129161421879 0.845889794399702 0.647058823529412 30.3 30 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0631921496919385 0.109129161421879 0.845889794399702 0.647058823529412 30.3 30 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0024350898764755 0.00684808872376411 0.844287730395157 0.645833333333333 30.3 30 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0142347284823609 0.0312601222704948 0.843409179166859 0.645161290322581 30.3 30 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0142347284823609 0.0312601222704948 0.843409179166859 0.645161290322581 30.3 30 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000164020143937997 0.000655619845010588 0.84285430470688 0.644736842105263 30.3 30 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00349050133162664 0.00930146703165675 0.842472057856673 0.644444444444444 30.3 30 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.16698756139691e-14 4.74463799962228e-13 0.842115606806173 0.644171779141104 30.3 30 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.29784150344202e-07 2.12605192320729e-06 0.841049992651707 0.643356643356643 30.3 30 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 6.28110231492721e-06 3.42452436557143e-05 0.840397003526977 0.642857142857143 30.3 30 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0207220838879538 0.0430474822957055 0.840397003526977 0.642857142857143 30.3 30 3 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0953159433077371 0.153606554164111 0.840397003526977 0.642857142857143 30.3 30 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000330004942364838 0.00120719031615724 0.840397003526977 0.642857142857143 30.3 30 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000330004942364838 0.00120719031615724 0.840397003526977 0.642857142857143 30.3 30 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00501169233615614 0.012872993130596 0.840397003526977 0.642857142857143 30.3 30 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00501169233615614 0.012872993130596 0.840397003526977 0.642857142857143 30.3 30 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00181117859103702 0.00525981047968505 0.83863516494516 0.641509433962264 30.3 30 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0072094330857824 0.0172131263105174 0.838002710069635 0.641025641025641 30.3 30 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0072094330857824 0.0172131263105174 0.838002710069635 0.641025641025641 30.3 30 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0072094330857824 0.0172131263105174 0.838002710069635 0.641025641025641 30.3 30 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000665536407486153 0.0022283724890654 0.837478958375842 0.640625 30.3 30 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0302961904275287 0.0584959009204523 0.836661905733524 0.64 30.3 30 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0302961904275287 0.0584959009204523 0.836661905733524 0.64 30.3 30 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0302961904275287 0.0584959009204523 0.836661905733524 0.64 30.3 30 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0302961904275287 0.0584959009204523 0.836661905733524 0.64 30.3 30 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0302961904275287 0.0584959009204523 0.836661905733524 0.64 30.3 30 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0302961904275287 0.0584959009204523 0.836661905733524 0.64 30.3 30 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0302961904275287 0.0584959009204523 0.836661905733524 0.64 30.3 30 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000946099094386456 0.00296541632447561 0.835804670174371 0.639344262295082 30.3 30 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000946099094386456 0.00296541632447561 0.835804670174371 0.639344262295082 30.3 30 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00134594596189064 0.00404067743411471 0.833957179745161 0.637931034482759 30.3 30 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.10179015530886e-26 6.67911337769577e-24 0.833571591540496 0.637636080870918 30.3 30 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.76042576794927e-23 3.1476975692893e-21 0.833365076858041 0.637478108581436 30.3 30 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.79617884107194e-61 3.97896249084537e-58 0.832982267752368 0.63718528082634 30.3 30 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00191634435262489 0.00552015792264215 0.831908144905492 0.636363636363636 30.3 30 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00191634435262489 0.00552015792264215 0.831908144905492 0.636363636363636 30.3 30 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00191634435262489 0.00552015792264215 0.831908144905492 0.636363636363636 30.3 30 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00191634435262489 0.00552015792264215 0.831908144905492 0.636363636363636 30.3 30 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0445278179146972 0.0815483718051662 0.831908144905492 0.636363636363636 30.3 30 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.146111635954658 0.220484472919914 0.831908144905492 0.636363636363636 30.3 30 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.146111635954658 0.220484472919914 0.831908144905492 0.636363636363636 30.3 30 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.146111635954658 0.220484472919914 0.831908144905492 0.636363636363636 30.3 30 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.146111635954658 0.220484472919914 0.831908144905492 0.636363636363636 30.3 30 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.146111635954658 0.220484472919914 0.831908144905492 0.636363636363636 30.3 30 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.146111635954658 0.220484472919914 0.831908144905492 0.636363636363636 30.3 30 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00759808286129072 0.0179901362922075 0.829009510254254 0.634146341463415 30.3 30 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00759808286129072 0.0179901362922075 0.829009510254254 0.634146341463415 30.3 30 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 9.19488726589618e-08 7.65165180080132e-07 0.828453376861865 0.633720930232558 30.3 30 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00141943716986094 0.00425233493202551 0.8279466775488 0.633333333333333 30.3 30 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0658776748373264 0.113491442243965 0.825653196447556 0.631578947368421 30.3 30 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0658776748373264 0.113491442243965 0.825653196447556 0.631578947368421 30.3 30 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 8.36093875834574e-06 4.44021234019055e-05 0.825089225684956 0.631147540983607 30.3 30 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00556266718758629 0.0142112664415355 0.824157447903267 0.630434782608696 30.3 30 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 6.27019963809564e-06 3.42452436557143e-05 0.823486127690476 0.62992125984252 30.3 30 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00286679621676578 0.00790980466233125 0.823104884112842 0.62962962962963 30.3 30 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0316608824869003 0.0609654070079284 0.823104884112842 0.62962962962963 30.3 30 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.015713310762245 0.0334230810383776 0.821721514559711 0.628571428571429 30.3 30 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.00299447565647144 0.00816310126275645 0.817052642317894 0.625 30.3 30 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00155679248304016 0.00459609067088411 0.817052642317894 0.625 30.3 30 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.022668869465827 0.0460825732141026 0.817052642317894 0.625 30.3 30 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0982942320298716 0.158048239749726 0.817052642317894 0.625 30.3 30 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0982942320298716 0.158048239749726 0.817052642317894 0.625 30.3 30 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.229591109532048 0.30763479177411 0.817052642317894 0.625 30.3 30 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.229591109532048 0.30763479177411 0.817052642317894 0.625 30.3 30 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.229591109532048 0.30763479177411 0.817052642317894 0.625 30.3 30 3 THYROXINE BIOSYNTHESIS%REACTOME%REACT_219697.1 THYROXINE BIOSYNTHESIS 0.229591109532048 0.30763479177411 0.817052642317894 0.625 30.3 30 3 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.229591109532048 0.30763479177411 0.817052642317894 0.625 30.3 30 3 RELAXIN RECEPTORS%REACTOME%REACT_198713.2 RELAXIN RECEPTORS 0.229591109532048 0.30763479177411 0.817052642317894 0.625 30.3 30 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.229591109532048 0.30763479177411 0.817052642317894 0.625 30.3 30 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.229591109532048 0.30763479177411 0.817052642317894 0.625 30.3 30 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 6.43323002488047e-18 4.57724316270246e-16 0.816062275478721 0.624242424242424 30.3 30 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000167957127578056 0.000669476169589844 0.815295539861297 0.623655913978495 30.3 30 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0082743450818179 0.0193339787379752 0.813421297240926 0.622222222222222 30.3 30 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00162043882628362 0.00475440092742596 0.812100808122028 0.621212121212121 30.3 30 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0327860482449057 0.0625396067727892 0.811417796508805 0.620689655172414 30.3 30 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00603053821439147 0.0148983609011789 0.810516221179351 0.62 30.3 30 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.3385977687105e-06 1.32582654377492e-05 0.809672812000184 0.619354838709677 30.3 30 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.3385977687105e-06 1.32582654377492e-05 0.809672812000184 0.619354838709677 30.3 30 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 9.64987810502601e-05 0.000408683825697976 0.809271188581533 0.619047619047619 30.3 30 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0678349518767977 0.116722051415578 0.809271188581533 0.619047619047619 30.3 30 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 5.88033250626655e-33 1.39461885940288e-30 0.808710363087021 0.618618618618619 30.3 30 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00440562304442247 0.0113778613288805 0.808139340765336 0.618181818181818 30.3 30 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00623457935042308 0.0153757476874385 0.80448260166685 0.615384615384615 30.3 30 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0168465549252814 0.0357800711323513 0.80448260166685 0.615384615384615 30.3 30 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0475567030635361 0.0867604980248871 0.80448260166685 0.615384615384615 30.3 30 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0475567030635361 0.0867604980248871 0.80448260166685 0.615384615384615 30.3 30 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0475567030635361 0.0867604980248871 0.80448260166685 0.615384615384615 30.3 30 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.148328932724267 0.222581887237444 0.80448260166685 0.615384615384615 30.3 30 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.148328932724267 0.222581887237444 0.80448260166685 0.615384615384615 30.3 30 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.148328932724267 0.222581887237444 0.80448260166685 0.615384615384615 30.3 30 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.148328932724267 0.222581887237444 0.80448260166685 0.615384615384615 30.3 30 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.148328932724267 0.222581887237444 0.80448260166685 0.615384615384615 30.3 30 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.05351801845784e-09 1.66572904473945e-08 0.802304399676777 0.613718411552347 30.3 30 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000496745766048952 0.00172828661390625 0.802197139730296 0.613636363636364 30.3 30 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0337020630201311 0.0642008509740918 0.801238720208516 0.612903225806452 30.3 30 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00882458571494942 0.0204851312763018 0.800378098597121 0.612244897959184 30.3 30 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00641962952642712 0.0157774314613226 0.798895916933052 0.611111111111111 30.3 30 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0240733068803795 0.0488677827257918 0.798895916933052 0.611111111111111 30.3 30 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.100132828727667 0.160460602792197 0.798895916933052 0.611111111111111 30.3 30 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.000378424233294703 0.00134602306325836 0.798131423232638 0.610526315789474 30.3 30 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0692146589200515 0.118952245945934 0.795738225561775 0.608695652173913 30.3 30 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.43019998267892e-08 1.44338622365398e-07 0.794623746254266 0.607843137254902 30.3 30 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0344355792245283 0.0655104668937216 0.792293471338564 0.606060606060606 30.3 30 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0176865995196614 0.0375082430946022 0.790450928381963 0.604651162790698 30.3 30 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.23155389892251e-14 1.2773614439352e-12 0.786496202036087 0.601626016260163 30.3 30 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0350098581295972 0.0663138442538689 0.784370536625179 0.6 30.3 30 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.148920397808193 0.223067080085324 0.784370536625179 0.6 30.3 30 3 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.227393269930933 0.30763479177411 0.784370536625178 0.6 30.3 30 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.227393269930933 0.30763479177411 0.784370536625178 0.6 30.3 30 3 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.227393269930933 0.30763479177411 0.784370536625178 0.6 30.3 30 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.227393269930933 0.30763479177411 0.784370536625178 0.6 30.3 30 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.227393269930933 0.30763479177411 0.784370536625178 0.6 30.3 30 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.227393269930933 0.30763479177411 0.784370536625178 0.6 30.3 30 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 2.18269037453004e-05 0.000106005747541169 0.782705206398798 0.598726114649682 30.3 30 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.00384184156008975 0.010161599516743 0.774049871669584 0.592105263157895 30.3 30 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.101500812044276 0.16210511283839 0.7724861345551 0.590909090909091 30.3 30 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 4.22242417726296e-07 2.60108640876415e-06 0.771770206719553 0.590361445783133 30.3 30 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0357590782954534 0.0671308290427839 0.770962493264064 0.58974358974359 30.3 30 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0501550785321607 0.0897744361651127 0.768990722181548 0.588235294117647 30.3 30 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0501550785321607 0.0897744361651127 0.768990722181548 0.588235294117647 30.3 30 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.148440063941205 0.222581887237444 0.768990722181548 0.588235294117647 30.3 30 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0188022461624582 0.0393464651311442 0.764637944508822 0.584905660377358 30.3 30 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.101392242342611 0.16210511283839 0.762582466163368 0.583333333333333 30.3 30 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.22360733329811 0.30763479177411 0.762582466163368 0.583333333333333 30.3 30 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.22360733329811 0.30763479177411 0.762582466163368 0.583333333333333 30.3 30 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.22360733329811 0.30763479177411 0.762582466163368 0.583333333333333 30.3 30 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0188944274443074 0.039481307273494 0.760601732485022 0.581818181818182 30.3 30 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00027665471720982 0.0010278842365263 0.760264586327005 0.581560283687943 30.3 30 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 1.54548988996182e-06 8.97645760577824e-06 0.75873751255246 0.580392156862745 30.3 30 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0101169250412579 0.0234087550141626 0.757845929106453 0.579710144927536 30.3 30 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.100917420622142 0.161535983740503 0.754202439062672 0.576923076923077 30.3 30 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0707165347567378 0.121386765933459 0.752678797771636 0.575757575757576 30.3 30 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 8.95807341224332e-06 4.68652149471406e-05 0.7518286974805 0.575107296137339 30.3 30 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.219012918612973 0.303939386624275 0.747019558690646 0.571428571428571 30.3 30 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.219012918612973 0.303939386624275 0.747019558690646 0.571428571428571 30.3 30 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.219012918612973 0.303939386624275 0.747019558690646 0.571428571428571 30.3 30 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.219012918612973 0.303939386624275 0.747019558690646 0.571428571428571 30.3 30 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0259520714119975 0.052308495211434 0.743799646799738 0.568965517241379 30.3 30 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0259520714119975 0.052308495211434 0.743799646799738 0.568965517241379 30.3 30 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0259520714119975 0.052308495211434 0.743799646799738 0.568965517241379 30.3 30 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0991838114021117 0.159119011978811 0.740794395701557 0.566666666666667 30.3 30 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0991838114021117 0.159119011978811 0.740794395701557 0.566666666666667 30.3 30 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0256873996606358 0.0519959739930081 0.737983031771001 0.564516129032258 30.3 30 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.21401118238032 0.303939386624275 0.735347378086105 0.5625 30.3 30 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0485919098032467 0.0871958230138967 0.732079167516833 0.56 30.3 30 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0248839874597843 0.0504414731556597 0.72834406972338 0.557142857142857 30.3 30 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0178968623115979 0.0378976712342318 0.726269015393684 0.555555555555556 30.3 30 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.208824107958127 0.300765896380986 0.726269015393684 0.555555555555556 30.3 30 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198585.2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.339922267128022 0.441743731619339 0.726269015393684 0.555555555555556 30.3 30 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0939289163254098 0.152930031957732 0.722446546891612 0.552631578947368 30.3 30 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0123925856374773 0.0278149043566722 0.719006325239747 0.55 30.3 30 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0631466247822197 0.109129161421879 0.71530646421793 0.547169811320755 30.3 30 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.130823755027925 0.202551083390216 0.713064124204708 0.545454545454545 30.3 30 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.324931230702462 0.426547178311442 0.713064124204708 0.545454545454545 30.3 30 3 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.324931230702462 0.426547178311442 0.713064124204708 0.545454545454545 30.3 30 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.324931230702462 0.426547178311442 0.713064124204708 0.545454545454545 30.3 30 3 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.324931230702462 0.426547178311442 0.713064124204708 0.545454545454545 30.3 30 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.324931230702462 0.426547178311442 0.713064124204708 0.545454545454545 30.3 30 3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.324931230702462 0.426547178311442 0.713064124204708 0.545454545454545 30.3 30 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.324931230702462 0.426547178311442 0.713064124204708 0.545454545454545 30.3 30 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00122407268948526 0.0037459256712635 0.710047778501642 0.543147208121827 30.3 30 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0214107483933126 0.0438381222499048 0.709271229927023 0.542553191489362 30.3 30 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0152276324687735 0.0325653363626165 0.708621357075707 0.542056074766355 30.3 30 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0293625983022762 0.0572369553207385 0.707471464407024 0.541176470588235 30.3 30 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0293625983022762 0.0572369553207385 0.707471464407024 0.541176470588235 30.3 30 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0590812174764925 0.103283258561485 0.70721933630139 0.540983606557377 30.3 30 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.125427630265137 0.194426490051514 0.706640123085746 0.540540540540541 30.3 30 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.311432133967593 0.412249234079893 0.703922276458493 0.538461538461538 30.3 30 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.311432133967593 0.412249234079893 0.703922276458493 0.538461538461538 30.3 30 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.311432133967593 0.412249234079893 0.703922276458493 0.538461538461538 30.3 30 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0266127919117765 0.0535278454820761 0.70081216330772 0.536082474226804 30.3 30 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.29911865667558 0.397428429924696 0.697218254777936 0.533333333333333 30.3 30 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.173700184250379 0.259365542694952 0.69449474597021 0.53125 30.3 30 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.169144302712988 0.252828091135065 0.692091649963393 0.529411764705882 30.3 30 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.287778690624324 0.3834354651296 0.692091649963393 0.529411764705882 30.3 30 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.267439808642406 0.3566699603544 0.684767928799759 0.523809523809524 30.3 30 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.14449607195565 0.219442807249616 0.682061336195807 0.521739130434783 30.3 30 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.258233571876541 0.344715171463713 0.682061336195807 0.521739130434783 30.3 30 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.241380759391746 0.322824079524864 0.677851081034105 0.518518518518518 30.3 30 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.219256390299236 0.303939386624275 0.67344945063778 0.515151515151515 30.3 30 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.219256390299236 0.303939386624275 0.67344945063778 0.515151515151515 30.3 30 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.194248584111067 0.280340502221144 0.669584604436128 0.51219512195122 30.3 30 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.188644088487102 0.272528464890504 0.668843093246276 0.511627906976744 30.3 30 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0312825248536543 0.0603184727191736 0.665821780572098 0.509316770186335 30.3 30 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0368673144726106 0.0687577830858779 0.661711769580912 0.506172839506173 30.3 30 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.113301893577218 0.178825868854943 0.661711769580912 0.506172839506173 30.3 30 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.336521224940848 0.440948161225439 0.653642113854315 0.5 30.3 30 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.38422613097084 0.487737541812226 0.653642113854315 0.5 30.3 30 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.403851349322212 0.500157067089215 0.653642113854315 0.5 30.3 30 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.403851349322212 0.500157067089215 0.653642113854315 0.5 30.3 30 3 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.403851349322212 0.500157067089215 0.653642113854315 0.5 30.3 30 3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.403851349322212 0.500157067089215 0.653642113854315 0.5 30.3 30 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.403851349322212 0.500157067089215 0.653642113854315 0.5 30.3 30 3 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.403851349322212 0.500157067089215 0.653642113854315 0.5 30.3 30 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.215379890325029 0.303939386624275 0.653642113854315 0.5 30.3 30 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.323262751381763 0.426547178311442 0.653642113854315 0.5 30.3 30 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.350935155712203 0.455639349067942 0.653642113854315 0.5 30.3 30 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.426255128106812 0.524440811874803 0.653642113854315 0.5 30.3 30 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.426255128106812 0.524440811874803 0.653642113854315 0.5 30.3 30 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.426255128106812 0.524440811874803 0.653642113854315 0.5 30.3 30 3 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.426255128106812 0.524440811874803 0.653642113854315 0.5 30.3 30 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.45245126432511 0.544702325833022 0.653642113854315 0.5 30.3 30 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.45245126432511 0.544702325833022 0.653642113854315 0.5 30.3 30 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.45245126432511 0.544702325833022 0.653642113854315 0.5 30.3 30 3 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.45245126432511 0.544702325833022 0.653642113854315 0.5 30.3 30 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.166338060329667 0.248894910461742 0.645368163046033 0.493670886075949 30.3 30 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.233485103604305 0.312558139632103 0.641757711784237 0.490909090909091 30.3 30 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0807230509222393 0.13438293768472 0.641611890899942 0.49079754601227 30.3 30 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.088575862403836 0.144711196556439 0.640990976166813 0.490322580645161 30.3 30 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.323006040621485 0.426547178311442 0.634966624887049 0.485714285714286 30.3 30 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.112027691771446 0.178516691367041 0.633087330399777 0.484276729559748 30.3 30 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.112027691771446 0.178516691367041 0.633087330399777 0.484276729559748 30.3 30 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.295687738547574 0.393237057900185 0.62149578038607 0.475409836065574 30.3 30 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.447261079458437 0.540282271705735 0.619239897335667 0.473684210526316 30.3 30 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.447261079458437 0.540282271705735 0.619239897335667 0.473684210526316 30.3 30 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.204611362033946 0.294996928241444 0.616291135919783 0.471428571428571 30.3 30 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.355924760443391 0.460832987613438 0.613623208924459 0.469387755102041 30.3 30 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.424287216330066 0.524440811874803 0.610065972930694 0.466666666666667 30.3 30 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.495492455388016 0.591514902698949 0.610065972930694 0.466666666666667 30.3 30 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.25042765249356 0.334608966665104 0.607610979075842 0.464788732394366 30.3 30 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.524674837369002 0.621688303771327 0.603361951250137 0.461538461538462 30.3 30 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.293921816979942 0.391254205390512 0.601159900333166 0.45985401459854 30.3 30 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.327769562251942 0.429876577958077 0.595967809690699 0.455882352941176 30.3 30 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.558717959010651 0.655445717784136 0.594220103503923 0.454545454545455 30.3 30 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.30991143824036 0.411384306544807 0.593577703392027 0.454054054054054 30.3 30 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.355750365010128 0.460832987613438 0.591617679692957 0.452554744525547 30.3 30 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.487478876273306 0.582436978116636 0.590386425416801 0.451612903225806 30.3 30 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.552536321669519 0.653582033030529 0.581015212314947 0.444444444444444 30.3 30 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.582032929934709 0.672813045732812 0.571936849622526 0.4375 30.3 30 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.582032929934709 0.672813045732812 0.571936849622526 0.4375 30.3 30 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.582032929934709 0.672813045732812 0.571936849622526 0.4375 30.3 30 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.543579448263446 0.643522092245328 0.565651829297004 0.432692307692308 30.3 30 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.572447723347987 0.670999267153366 0.564364166596165 0.431707317073171 30.3 30 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.615292453404094 0.706097710640343 0.560264669017985 0.428571428571429 30.3 30 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.615292453404094 0.706097710640343 0.560264669017985 0.428571428571429 30.3 30 3 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.615292453404094 0.706097710640343 0.560264669017985 0.428571428571429 30.3 30 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.593603139589772 0.685630899055394 0.55720311344958 0.426229508196721 30.3 30 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.65701617535468 0.749145847379575 0.550015925072534 0.420731707317073 30.3 30 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.629750685380216 0.722107353179732 0.548215966458458 0.419354838709677 30.3 30 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.641453190902544 0.734933889415717 0.544701761545263 0.416666666666667 30.3 30 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.653334266799108 0.745545037413897 0.544701761545263 0.416666666666667 30.3 30 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.662996696689607 0.755359727293284 0.538293505527083 0.411764705882353 30.3 30 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.684903499349938 0.765006027923832 0.531084217506631 0.40625 30.3 30 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.754730978009772 0.823605967567412 0.528195647559043 0.404040404040404 30.3 30 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.695159118748145 0.775134824539488 0.522913691083452 0.4 30.3 30 3 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.695159118748145 0.775134824539488 0.522913691083452 0.4 30.3 30 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.697784757719666 0.775134824539488 0.522913691083452 0.4 30.3 30 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.702351452822011 0.779599155511484 0.522913691083452 0.4 30.3 30 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.707736970934989 0.784964699641846 0.522913691083452 0.4 30.3 30 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.731520154983445 0.803824849838952 0.513575946599819 0.392857142857143 30.3 30 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.801868799383529 0.87037322770615 0.512984950113513 0.392405063291139 30.3 30 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.756991467074845 0.825439737660923 0.506045507500115 0.387096774193548 30.3 30 3 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.733746410192924 0.805649029093002 0.502801626041781 0.384615384615385 30.3 30 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.800412180628457 0.869455368728468 0.500662044654369 0.382978723404255 30.3 30 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.832030984354242 0.888207119832022 0.493314802908917 0.377358490566038 30.3 30 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.951145201289029 0.998141313742101 0.491988687847334 0.376344086021505 30.3 30 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.802975352187626 0.870910004697402 0.484179343595789 0.37037037037037 30.3 30 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.787561767344416 0.856150034324754 0.481631031261074 0.368421052631579 30.3 30 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.89762063099654 0.947562431682549 0.478723801696118 0.366197183098592 30.3 30 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.837583994287278 0.892795523498724 0.475376082803138 0.363636363636364 30.3 30 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.835903234065435 0.89167189061103 0.457549479698021 0.35 30.3 30 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.996662800552175 1 0.451826345982246 0.345622119815668 30.3 30 3 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.863865297170731 0.918744632192788 0.43576140923621 0.333333333333333 30.3 30 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999874851290161 1 0.429536246247122 0.328571428571429 30.3 30 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999993189608251 1 0.42789973432731 0.327319587628866 30.3 30 3 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.906059587573918 0.955053920827915 0.415954072452746 0.318181818181818 30.3 30 3 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.906059587573918 0.955053920827915 0.415954072452746 0.318181818181818 30.3 30 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.946524671752154 0.994025540888056 0.410860757279855 0.314285714285714 30.3 30 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.968673592022765 1 0.408526321158947 0.3125 30.3 30 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.965639404749864 1 0.379534130625086 0.290322580645161 30.3 30 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.965639404749864 1 0.379534130625086 0.290322580645161 30.3 30 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.965639404749864 1 0.379534130625086 0.290322580645161 30.3 30 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.976728678872751 1 0.37842438170513 0.289473684210526 30.3 30 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999396435815748 1 0.375238991286737 0.287037037037037 30.3 30 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999984955496988 1 0.371387564689952 0.284090909090909 30.3 30 3 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.972966578506083 1 0.341030668097904 0.260869565217391 30.3 30 3 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.98680980025785 1 0.313748214650071 0.24 30.3 30 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.301849842669919 0.230898404701931 30.3 30 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999062858441663 1 0.299585968849895 0.229166666666667 30.3 30 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999997311305572 1 0.2759822258496 0.211111111111111 30.3 30 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.998073037264392 1 0.261456845541726 0.2 30.3 30 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.261220446947204 0.199819168173599 30.3 30 3 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999998824093073 1 0.166887348218123 0.127659574468085 30.3 30 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0231937524270886 0.017741935483871 30.3 30 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 6.8827004460721e-06 3.03222375689183e-05 1.6919536581495 1 30.1 30 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 6.8827004460721e-06 3.03222375689183e-05 1.6919536581495 1 30.1 30 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 6.8827004460721e-06 3.03222375689183e-05 1.6919536581495 1 30.1 30 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 6.8827004460721e-06 3.03222375689183e-05 1.6919536581495 1 30.1 30 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00262584782640857 0.00664872145369998 1.6919536581495 1 30.1 30 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00262584782640857 0.00664872145369998 1.6919536581495 1 30.1 30 1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00262584782640857 0.00664872145369998 1.6919536581495 1 30.1 30 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00262584782640857 0.00664872145369998 1.6919536581495 1 30.1 30 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 4.99285731513735e-05 0.00019465303998467 1.6919536581495 1 30.1 30 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 4.99285731513735e-05 0.00019465303998467 1.6919536581495 1 30.1 30 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000134465779276489 0.000479560912056251 1.6919536581495 1 30.1 30 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.000362120165947389 0.00115565851571014 1.6919536581495 1 30.1 30 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.000362120165947389 0.00115565851571014 1.6919536581495 1 30.1 30 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.000362120165947389 0.00115565851571014 1.6919536581495 1 30.1 30 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.000362120165947389 0.00115565851571014 1.6919536581495 1 30.1 30 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.000362120165947389 0.00115565851571014 1.6919536581495 1 30.1 30 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000362120165947389 0.00115565851571014 1.6919536581495 1 30.1 30 1 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.000975151224171305 0.00275872801589616 1.6919536581495 1 30.1 30 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.000975151224171305 0.00275872801589616 1.6919536581495 1 30.1 30 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000975151224171305 0.00275872801589616 1.6919536581495 1 30.1 30 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.000975151224171305 0.00275872801589616 1.6919536581495 1 30.1 30 1 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605631 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00707042410287785 0.0154313090466184 1.6919536581495 1 30.1 30 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 7.56992691840737e-10 7.08684605585111e-09 1.62427551182352 0.96 30.1 30 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.30778313867945e-08 9.96658745634144e-08 1.61504667368816 0.954545454545455 30.1 30 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 9.29904980928367e-06 4.03714818389138e-05 1.5791567476062 0.933333333333333 30.1 30 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 2.34415552031217e-05 9.61306428070378e-05 1.57109982542454 0.928571428571429 30.1 30 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 2.34415552031217e-05 9.61306428070378e-05 1.57109982542454 0.928571428571429 30.1 30 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 5.88122612780429e-05 0.000224369565143847 1.56180337675338 0.923076923076923 30.1 30 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 5.88122612780429e-05 0.000224369565143847 1.56180337675338 0.923076923076923 30.1 30 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 5.88122612780429e-05 0.000224369565143847 1.56180337675338 0.923076923076923 30.1 30 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000146747307461702 0.000515608440785188 1.55095751997038 0.916666666666667 30.1 30 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000146747307461702 0.000515608440785188 1.55095751997038 0.916666666666667 30.1 30 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000146747307461702 0.000515608440785188 1.55095751997038 0.916666666666667 30.1 30 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000146747307461702 0.000515608440785188 1.55095751997038 0.916666666666667 30.1 30 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000146747307461702 0.000515608440785188 1.55095751997038 0.916666666666667 30.1 30 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000146747307461702 0.000515608440785188 1.55095751997038 0.916666666666667 30.1 30 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 9.7181088171022e-08 6.40225409571131e-07 1.54482725309302 0.91304347826087 30.1 30 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 9.7181088171022e-08 6.40225409571131e-07 1.54482725309302 0.91304347826087 30.1 30 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000363833461024695 0.00115565851571014 1.53813968922682 0.909090909090909 30.1 30 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000363833461024695 0.00115565851571014 1.53813968922682 0.909090909090909 30.1 30 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000363833461024695 0.00115565851571014 1.53813968922682 0.909090909090909 30.1 30 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000363833461024695 0.00115565851571014 1.53813968922682 0.909090909090909 30.1 30 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.000363833461024695 0.00115565851571014 1.53813968922682 0.909090909090909 30.1 30 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 5.88751670900006e-07 3.25989738401054e-06 1.53081521451621 0.904761904761905 30.1 30 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.43960067941888e-06 6.99164425533469e-06 1.52275829233455 0.9 30.1 30 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.000895300634402533 0.00257897328492875 1.52275829233455 0.9 30.1 30 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.000895300634402533 0.00257897328492875 1.52275829233455 0.9 30.1 30 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.000895300634402533 0.00257897328492875 1.52275829233455 0.9 30.1 30 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00218335525931459 0.00569031965934919 1.503958807244 0.888888888888889 30.1 30 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00218335525931459 0.00569031965934919 1.503958807244 0.888888888888889 30.1 30 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00218335525931459 0.00569031965934919 1.503958807244 0.888888888888889 30.1 30 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00218335525931459 0.00569031965934919 1.503958807244 0.888888888888889 30.1 30 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00218335525931459 0.00569031965934919 1.503958807244 0.888888888888889 30.1 30 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.03809468063453e-05 8.43083933297364e-05 1.4929002866025 0.882352941176471 30.1 30 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 4.86779758472884e-05 0.000190823029285651 1.48045945088081 0.875 30.1 30 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00526636863173872 0.0120632350027197 1.48045945088081 0.875 30.1 30 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00526636863173872 0.0120632350027197 1.48045945088081 0.875 30.1 30 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00526636863173872 0.0120632350027197 1.48045945088081 0.875 30.1 30 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00526636863173872 0.0120632350027197 1.48045945088081 0.875 30.1 30 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00526636863173872 0.0120632350027197 1.48045945088081 0.875 30.1 30 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.18977031608164e-06 5.87862208258391e-06 1.47126405056478 0.869565217391304 30.1 30 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.65927041693198e-07 1.00903495867274e-06 1.45024599269957 0.857142857142857 30.1 30 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 6.54469473053211e-06 2.95653987350705e-05 1.45024599269957 0.857142857142857 30.1 30 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00027103649772757 0.000899032485469305 1.45024599269957 0.857142857142857 30.1 30 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00027103649772757 0.000899032485469305 1.45024599269957 0.857142857142857 30.1 30 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00027103649772757 0.000899032485469305 1.45024599269957 0.857142857142857 30.1 30 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00027103649772757 0.000899032485469305 1.45024599269957 0.857142857142857 30.1 30 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0125300274398321 0.0257290462436957 1.45024599269957 0.857142857142857 30.1 30 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0125300274398321 0.0257290462436957 1.45024599269957 0.857142857142857 30.1 30 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0125300274398321 0.0257290462436957 1.45024599269957 0.857142857142857 30.1 30 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0125300274398321 0.0257290462436957 1.45024599269957 0.857142857142857 30.1 30 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0125300274398321 0.0257290462436957 1.45024599269957 0.857142857142857 30.1 30 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0125300274398321 0.0257290462436957 1.45024599269957 0.857142857142857 30.1 30 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0125300274398321 0.0257290462436957 1.45024599269957 0.857142857142857 30.1 30 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0125300274398321 0.0257290462436957 1.45024599269957 0.857142857142857 30.1 30 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.65511218284612e-10 2.7181472202806e-09 1.44435068378616 0.853658536585366 30.1 30 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.65511218284612e-10 2.7181472202806e-09 1.44435068378616 0.853658536585366 30.1 30 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 3.84824043335386e-07 2.16444511330535e-06 1.44129385694217 0.851851851851852 30.1 30 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.6437986686736e-11 2.22773857668813e-10 1.43996056012723 0.851063829787234 30.1 30 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.78703541407925e-14 6.20163286305019e-13 1.43816060942708 0.85 30.1 30 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.78703541407925e-14 6.20163286305019e-13 1.43816060942708 0.85 30.1 30 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.78703541407925e-14 6.20163286305019e-13 1.43816060942708 0.85 30.1 30 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.78703541407925e-14 6.20163286305019e-13 1.43816060942708 0.85 30.1 30 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.78703541407925e-14 6.20163286305019e-13 1.43816060942708 0.85 30.1 30 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.78703541407925e-14 6.20163286305019e-13 1.43816060942708 0.85 30.1 30 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.78703541407925e-14 6.20163286305019e-13 1.43816060942708 0.85 30.1 30 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 2.31198497764536e-08 1.67854827713742e-07 1.43559704327836 0.848484848484849 30.1 30 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 8.87264390409812e-07 4.78248949830743e-06 1.43165309535727 0.846153846153846 30.1 30 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.000630390061471827 0.00192912915585894 1.43165309535727 0.846153846153846 30.1 30 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000630390061471827 0.00192912915585894 1.43165309535727 0.846153846153846 30.1 30 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 3.49942921594732e-05 0.000137941489592605 1.42480308054695 0.842105263157895 30.1 30 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 4.62520138741087e-06 2.09973319659795e-05 1.40996138179125 0.833333333333333 30.1 30 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 4.62520138741087e-06 2.09973319659795e-05 1.40996138179125 0.833333333333333 30.1 30 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 4.62520138741087e-06 2.09973319659795e-05 1.40996138179125 0.833333333333333 30.1 30 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 7.99109457902883e-05 0.000299245462788369 1.40996138179125 0.833333333333333 30.1 30 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 7.99109457902883e-05 0.000299245462788369 1.40996138179125 0.833333333333333 30.1 30 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00144926422883967 0.00396596730315163 1.40996138179125 0.833333333333333 30.1 30 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00144926422883967 0.00396596730315163 1.40996138179125 0.833333333333333 30.1 30 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00144926422883967 0.00396596730315163 1.40996138179125 0.833333333333333 30.1 30 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00144926422883967 0.00396596730315163 1.40996138179125 0.833333333333333 30.1 30 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0292933054852243 0.0546322066913161 1.40996138179125 0.833333333333333 30.1 30 1 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0292933054852243 0.0546322066913161 1.40996138179125 0.833333333333333 30.1 30 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0292933054852243 0.0546322066913161 1.40996138179125 0.833333333333333 30.1 30 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0292933054852243 0.0546322066913161 1.40996138179125 0.833333333333333 30.1 30 1 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605630 MULTIFUNCTIONAL ANION EXCHANGERS 0.0292933054852243 0.0546322066913161 1.40996138179125 0.833333333333333 30.1 30 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 6.20837064954924e-07 3.4242292381041e-06 1.40023751019269 0.827586206896552 30.1 30 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.74311274188403e-13 3.30726590893464e-12 1.39653317815514 0.825396825396825 30.1 30 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000180730778038355 0.000618220906607163 1.393373600829 0.823529411764706 30.1 30 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000180730778038355 0.000618220906607163 1.393373600829 0.823529411764706 30.1 30 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.000180730778038355 0.000618220906607163 1.393373600829 0.823529411764706 30.1 30 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.000180730778038355 0.000618220906607163 1.393373600829 0.823529411764706 30.1 30 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000180730778038355 0.000618220906607163 1.393373600829 0.823529411764706 30.1 30 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 7.12987810320083e-10 6.71908380189059e-09 1.3911618967007 0.822222222222222 30.1 30 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 7.12987810320083e-10 6.71908380189059e-09 1.3911618967007 0.822222222222222 30.1 30 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 6.19272559203199e-12 8.62229853673025e-11 1.38981907633709 0.821428571428571 30.1 30 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.58638791186022e-09 1.41654451861367e-08 1.38432572030414 0.818181818181818 30.1 30 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 2.33982585861595e-05 9.61306428070378e-05 1.38432572030414 0.818181818181818 30.1 30 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0032869029146028 0.00788745842745327 1.38432572030414 0.818181818181818 30.1 30 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.92442226752142e-13 9.3671698740922e-12 1.37471234724647 0.8125 30.1 30 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00040435725273145 0.001267401697438 1.37471234724647 0.8125 30.1 30 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00040435725273145 0.001267401697438 1.37471234724647 0.8125 30.1 30 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00040435725273145 0.001267401697438 1.37471234724647 0.8125 30.1 30 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00040435725273145 0.001267401697438 1.37471234724647 0.8125 30.1 30 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00040435725273145 0.001267401697438 1.37471234724647 0.8125 30.1 30 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 5.65461686348495e-08 3.92513160816541e-07 1.37185431741851 0.810810810810811 30.1 30 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 5.19468699706858e-05 0.000200326276336818 1.36967677088293 0.80952380952381 30.1 30 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 6.84383228601167e-06 3.03222375689183e-05 1.36657795465921 0.807692307692308 30.1 30 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 6.84383228601167e-06 3.03222375689183e-05 1.36657795465921 0.807692307692308 30.1 30 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 6.84383228601167e-06 3.03222375689183e-05 1.36657795465921 0.807692307692308 30.1 30 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 6.84383228601167e-06 3.03222375689183e-05 1.36657795465921 0.807692307692308 30.1 30 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 9.16582449084093e-07 4.92187481149685e-06 1.36447875657218 0.806451612903226 30.1 30 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 3.98371542589635e-13 6.66920829535354e-12 1.36366414238915 0.805970149253731 30.1 30 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.24174644024882e-07 7.91058521231417e-07 1.36296266906488 0.805555555555556 30.1 30 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.24174644024882e-07 7.91058521231417e-07 1.36296266906488 0.805555555555556 30.1 30 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 2.33274424881494e-09 1.97588992027599e-08 1.36091924677242 0.804347826086957 30.1 30 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.21510295965943e-13 2.40151598832689e-12 1.35832899316227 0.802816901408451 30.1 30 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 7.28768926593499e-16 2.36290042385695e-14 1.3535629265196 0.8 30.1 30 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.00364766637224e-06 9.44102857366786e-06 1.3535629265196 0.8 30.1 30 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000893711127585575 0.00257897328492875 1.3535629265196 0.8 30.1 30 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000893711127585575 0.00257897328492875 1.3535629265196 0.8 30.1 30 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000893711127585575 0.00257897328492875 1.3535629265196 0.8 30.1 30 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000893711127585575 0.00257897328492875 1.3535629265196 0.8 30.1 30 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000893711127585575 0.00257897328492875 1.3535629265196 0.8 30.1 30 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000893711127585575 0.00257897328492875 1.3535629265196 0.8 30.1 30 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000893711127585575 0.00257897328492875 1.3535629265196 0.8 30.1 30 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 5.18776775992232e-15 1.53795698382697e-13 1.3535629265196 0.8 30.1 30 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.49949740711059e-05 6.33170566860049e-05 1.3535629265196 0.8 30.1 30 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 1.49949740711059e-05 6.33170566860049e-05 1.3535629265196 0.8 30.1 30 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.49949740711059e-05 6.33170566860049e-05 1.3535629265196 0.8 30.1 30 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 1.49949740711059e-05 6.33170566860049e-05 1.3535629265196 0.8 30.1 30 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.49949740711059e-05 6.33170566860049e-05 1.3535629265196 0.8 30.1 30 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 1.49949740711059e-05 6.33170566860049e-05 1.3535629265196 0.8 30.1 30 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00011420054835893 0.000408310000790847 1.3535629265196 0.8 30.1 30 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00011420054835893 0.000408310000790847 1.3535629265196 0.8 30.1 30 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00733557375896279 0.0158640143753861 1.3535629265196 0.8 30.1 30 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00733557375896279 0.0158640143753861 1.3535629265196 0.8 30.1 30 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00733557375896279 0.0158640143753861 1.3535629265196 0.8 30.1 30 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00733557375896279 0.0158640143753861 1.3535629265196 0.8 30.1 30 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00733557375896279 0.0158640143753861 1.3535629265196 0.8 30.1 30 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.10049589121561e-08 8.60442666593303e-08 1.34587222807347 0.795454545454545 30.1 30 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.10049589121561e-08 8.60442666593303e-08 1.34587222807347 0.795454545454545 30.1 30 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.27432496027528e-09 2.70893280143704e-08 1.33946331270169 0.791666666666667 30.1 30 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 3.25625211026823e-05 0.000130308691107031 1.33946331270169 0.791666666666667 30.1 30 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 3.25625211026823e-05 0.000130308691107031 1.33946331270169 0.791666666666667 30.1 30 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.64971445052145e-12 3.77054366309202e-11 1.33841110271528 0.791044776119403 30.1 30 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.64971445052145e-12 3.77054366309202e-11 1.33841110271528 0.791044776119403 30.1 30 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.38890852113796e-13 4.19681089577693e-12 1.33100354441094 0.786666666666667 30.1 30 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.38890852113796e-13 4.19681089577693e-12 1.33100354441094 0.786666666666667 30.1 30 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.38890852113796e-13 4.19681089577693e-12 1.33100354441094 0.786666666666667 30.1 30 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.38890852113796e-13 4.19681089577693e-12 1.33100354441094 0.786666666666667 30.1 30 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.38890852113796e-13 4.19681089577693e-12 1.33100354441094 0.786666666666667 30.1 30 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 5.07898359811802e-08 3.54284002947154e-07 1.32939215997461 0.785714285714286 30.1 30 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00194801979520076 0.00512390419329146 1.32939215997461 0.785714285714286 30.1 30 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00194801979520076 0.00512390419329146 1.32939215997461 0.785714285714286 30.1 30 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.56693014312346e-20 8.91896637465871e-19 1.32839336796862 0.785123966942149 30.1 30 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.56693014312346e-20 8.91896637465871e-19 1.32839336796862 0.785123966942149 30.1 30 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 7.16768882759811e-14 1.45708874309602e-12 1.32786236462366 0.784810126582278 30.1 30 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 7.16768882759811e-14 1.45708874309602e-12 1.32786236462366 0.784810126582278 30.1 30 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.08017757588141e-09 1.78318836775859e-08 1.32702247698 0.784313725490196 30.1 30 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.08017757588141e-09 1.78318836775859e-08 1.32702247698 0.784313725490196 30.1 30 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.49700669671619e-08 1.1331066645889e-07 1.3241376455083 0.782608695652174 30.1 30 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 3.36375853895878e-26 3.19108560062557e-24 1.3218387954293 0.78125 30.1 30 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.70315572124968e-06 1.26117724306173e-05 1.3218387954293 0.78125 30.1 30 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 2.70315572124968e-06 1.26117724306173e-05 1.3218387954293 0.78125 30.1 30 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.83065320069335e-10 1.91545551807841e-09 1.31915030974368 0.779661016949153 30.1 30 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.83065320069335e-10 1.91545551807841e-09 1.31915030974368 0.779661016949153 30.1 30 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 7.8488344240352e-07 4.26293564328324e-06 1.3159639563385 0.777777777777778 30.1 30 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 7.8488344240352e-07 4.26293564328324e-06 1.3159639563385 0.777777777777778 30.1 30 1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0160569154352232 0.0319363616555194 1.3159639563385 0.777777777777778 30.1 30 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0160569154352232 0.0319363616555194 1.3159639563385 0.777777777777778 30.1 30 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0160569154352232 0.0319363616555194 1.3159639563385 0.777777777777778 30.1 30 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0160569154352232 0.0319363616555194 1.3159639563385 0.777777777777778 30.1 30 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0160569154352232 0.0319363616555194 1.3159639563385 0.777777777777778 30.1 30 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0160569154352232 0.0319363616555194 1.3159639563385 0.777777777777778 30.1 30 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0160569154352232 0.0319363616555194 1.3159639563385 0.777777777777778 30.1 30 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 1.9954238575672e-05 8.30259692783078e-05 1.3159639563385 0.777777777777778 30.1 30 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 1.9954238575672e-05 8.30259692783078e-05 1.3159639563385 0.777777777777778 30.1 30 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.87637223444352e-14 6.20163286305019e-13 1.3137522522102 0.776470588235294 30.1 30 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.87637223444352e-14 6.20163286305019e-13 1.3137522522102 0.776470588235294 30.1 30 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.87637223444352e-14 6.20163286305019e-13 1.3137522522102 0.776470588235294 30.1 30 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.86504996126205e-10 3.87321555977176e-09 1.31272266580565 0.775862068965517 30.1 30 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.86504996126205e-10 3.87321555977176e-09 1.31272266580565 0.775862068965517 30.1 30 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 2.28789451643941e-07 1.34531979210466e-06 1.31126408506586 0.775 30.1 30 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000149012148678076 0.000519716391100249 1.3074187358428 0.772727272727273 30.1 30 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000149012148678076 0.000519716391100249 1.3074187358428 0.772727272727273 30.1 30 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000149012148678076 0.000519716391100249 1.3074187358428 0.772727272727273 30.1 30 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.38821509295499e-32 3.77603341919439e-30 1.30522139342961 0.771428571428571 30.1 30 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 1.65589233394754e-06 7.93378717578232e-06 1.30522139342961 0.771428571428571 30.1 30 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.65589233394754e-06 7.93378717578232e-06 1.30522139342961 0.771428571428571 30.1 30 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.00515246636357e-21 7.94628866464089e-20 1.30243914692084 0.76978417266187 30.1 30 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.34366061624478e-20 1.28270348342935e-18 1.30150281396115 0.769230769230769 30.1 30 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00417884478673247 0.00987790055069817 1.30150281396115 0.769230769230769 30.1 30 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00417884478673247 0.00987790055069817 1.30150281396115 0.769230769230769 30.1 30 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.00417884478673247 0.00987790055069817 1.30150281396115 0.769230769230769 30.1 30 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.00417884478673247 0.00987790055069817 1.30150281396115 0.769230769230769 30.1 30 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00417884478673247 0.00987790055069817 1.30150281396115 0.769230769230769 30.1 30 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00417884478673247 0.00987790055069817 1.30150281396115 0.769230769230769 30.1 30 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00417884478673247 0.00987790055069817 1.30150281396115 0.769230769230769 30.1 30 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00417884478673247 0.00987790055069817 1.30150281396115 0.769230769230769 30.1 30 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.10465334666778e-11 2.49576809359021e-10 1.29961657799889 0.768115942028985 30.1 30 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 6.24101721210974e-12 8.62229853673025e-11 1.29793705282701 0.767123287671233 30.1 30 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.20462325117987e-05 5.1787881765225e-05 1.29716447124795 0.766666666666667 30.1 30 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.09879127771073e-08 2.87724135143979e-07 1.29596450411451 0.765957446808511 30.1 30 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.50104057616146e-13 8.87950358670758e-12 1.29507563957122 0.765432098765432 30.1 30 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.50104057616146e-13 8.87950358670758e-12 1.29507563957122 0.765432098765432 30.1 30 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.20196072803528e-08 9.32034060008115e-08 1.2938469150555 0.764705882352941 30.1 30 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 3.46654243570477e-06 1.59640449385368e-05 1.2938469150555 0.764705882352941 30.1 30 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00113114329548401 0.00316231219935902 1.2938469150555 0.764705882352941 30.1 30 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00113114329548401 0.00316231219935902 1.2938469150555 0.764705882352941 30.1 30 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.4463266789375e-14 3.67521940022867e-13 1.29170655622166 0.763440860215054 30.1 30 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000313412319201311 0.00102761688991582 1.28910754906629 0.761904761904762 30.1 30 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000313412319201311 0.00102761688991582 1.28910754906629 0.761904761904762 30.1 30 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 8.81930867026746e-05 0.000327673008819598 1.28588478019362 0.76 30.1 30 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.3542559721883e-12 3.4184757636979e-11 1.28502809479709 0.759493670886076 30.1 30 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 7.19752717129206e-06 3.16113616195945e-05 1.28178307435568 0.757575757575758 30.1 30 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.26490736917197e-13 2.46570299497495e-12 1.2783649861574 0.755555555555556 30.1 30 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.13315239432521e-10 1.23089760085861e-09 1.27509551048948 0.753623188405797 30.1 30 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.13315239432521e-10 1.23089760085861e-09 1.27509551048948 0.753623188405797 30.1 30 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.20553043420635e-19 1.87014681496114e-17 1.2721456076312 0.75187969924812 30.1 30 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 3.07787293246613e-08 2.20091114718558e-07 1.26896524361213 0.75 30.1 30 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.23681910391003e-06 6.06894339608268e-06 1.26896524361213 0.75 30.1 30 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.000182425535552756 0.000622521671682427 1.26896524361213 0.75 30.1 30 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000650791942546589 0.00196202740305889 1.26896524361213 0.75 30.1 30 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000650791942546589 0.00196202740305889 1.26896524361213 0.75 30.1 30 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000650791942546589 0.00196202740305889 1.26896524361213 0.75 30.1 30 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000650791942546589 0.00196202740305889 1.26896524361213 0.75 30.1 30 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000650791942546589 0.00196202740305889 1.26896524361213 0.75 30.1 30 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000650791942546589 0.00196202740305889 1.26896524361213 0.75 30.1 30 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000650791942546589 0.00196202740305889 1.26896524361213 0.75 30.1 30 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00236177275214795 0.00606643073340529 1.26896524361213 0.75 30.1 30 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00236177275214795 0.00606643073340529 1.26896524361213 0.75 30.1 30 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00236177275214795 0.00606643073340529 1.26896524361213 0.75 30.1 30 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00236177275214795 0.00606643073340529 1.26896524361213 0.75 30.1 30 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00236177275214795 0.00606643073340529 1.26896524361213 0.75 30.1 30 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00236177275214795 0.00606643073340529 1.26896524361213 0.75 30.1 30 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00236177275214795 0.00606643073340529 1.26896524361213 0.75 30.1 30 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00879981897189219 0.018802015611115 1.26896524361213 0.75 30.1 30 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00879981897189219 0.018802015611115 1.26896524361213 0.75 30.1 30 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00879981897189219 0.018802015611115 1.26896524361213 0.75 30.1 30 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.00879981897189219 0.018802015611115 1.26896524361213 0.75 30.1 30 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00879981897189219 0.018802015611115 1.26896524361213 0.75 30.1 30 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.00879981897189219 0.018802015611115 1.26896524361213 0.75 30.1 30 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0343210038641124 0.0623739316713052 1.26896524361213 0.75 30.1 30 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.83879736901169e-18 2.37388818745818e-16 1.26563462617482 0.748031496062992 30.1 30 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 4.11225677011799e-11 4.75751332022594e-10 1.26332539808496 0.746666666666667 30.1 30 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.7012939281268e-10 4.58215154775646e-09 1.26265198369366 0.746268656716418 30.1 30 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.59274155290363e-09 1.41654451861367e-08 1.26225114179407 0.746031746031746 30.1 30 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.13794447528308e-07 1.28366877144634e-06 1.25996549011133 0.74468085106383 30.1 30 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.16933360716912e-12 3.1824347659811e-11 1.25912830373916 0.744186046511628 30.1 30 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 7.32428019258037e-07 4.0086348900161e-06 1.25912830373916 0.744186046511628 30.1 30 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 8.69730939633679e-06 3.79640223036419e-05 1.25687986033963 0.742857142857143 30.1 30 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 8.69730939633679e-06 3.79640223036419e-05 1.25687986033963 0.742857142857143 30.1 30 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 3.02033068005597e-05 0.000122448164037597 1.2553204560464 0.741935483870968 30.1 30 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.09262797705969e-08 8.60442666593303e-08 1.25437943621428 0.741379310344828 30.1 30 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000105626041294985 0.000380521156361429 1.25329900603667 0.740740740740741 30.1 30 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000105626041294985 0.000380521156361429 1.25329900603667 0.740740740740741 30.1 30 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000105626041294985 0.000380521156361429 1.25329900603667 0.740740740740741 30.1 30 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 6.87645545059312e-14 1.43899942738147e-12 1.25204570703063 0.74 30.1 30 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 3.24674899106434e-16 1.10002947959156e-14 1.25119262115257 0.739495798319328 30.1 30 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.1605227445932e-54 7.68605966389032e-52 1.2510924937021 0.73943661971831 30.1 30 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.000372799791572887 0.00118150134389358 1.25057444298007 0.739130434782609 30.1 30 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.22421622637509e-14 3.22603646320694e-13 1.2491994298487 0.738317757009346 30.1 30 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.22421622637509e-14 3.22603646320694e-13 1.2491994298487 0.738317757009346 30.1 30 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 6.47722459194587e-09 5.23698329223805e-08 1.24816253470045 0.737704918032787 30.1 30 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.37841775477405e-13 2.65066008789658e-12 1.24760219237286 0.737373737373737 30.1 30 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00133230521410869 0.00370287171811848 1.24670269547858 0.736842105263158 30.1 30 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00133230521410869 0.00370287171811848 1.24670269547858 0.736842105263158 30.1 30 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 7.30421210446092e-15 2.03801839698978e-13 1.24589314827372 0.736363636363636 30.1 30 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 1.75613736590346e-05 7.37163265982485e-05 1.24408357216875 0.735294117647059 30.1 30 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.75597576298389e-11 2.35731463276044e-10 1.24348401382072 0.734939759036145 30.1 30 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.06438797449855e-17 8.16006691030956e-16 1.24332958212501 0.734848484848485 30.1 30 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.75343852071984e-13 4.77822318900528e-12 1.24306799374249 0.73469387755102 30.1 30 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 2.5398576837568e-07 1.48123667376472e-06 1.24306799374249 0.73469387755102 30.1 30 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.29556469252159e-08 9.96534355382827e-08 1.2407660159763 0.733333333333333 30.1 30 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 6.09664134293872e-05 0.000231965792272775 1.2407660159763 0.733333333333333 30.1 30 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00484736863114252 0.0112893708054269 1.2407660159763 0.733333333333333 30.1 30 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00484736863114252 0.0112893708054269 1.2407660159763 0.733333333333333 30.1 30 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00484736863114252 0.0112893708054269 1.2407660159763 0.733333333333333 30.1 30 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00484736863114252 0.0112893708054269 1.2407660159763 0.733333333333333 30.1 30 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00484736863114252 0.0112893708054269 1.2407660159763 0.733333333333333 30.1 30 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00484736863114252 0.0112893708054269 1.2407660159763 0.733333333333333 30.1 30 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00484736863114252 0.0112893708054269 1.2407660159763 0.733333333333333 30.1 30 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000213125252456556 0.000723812014906154 1.2364276732631 0.730769230769231 30.1 30 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000213125252456556 0.000723812014906154 1.2364276732631 0.730769230769231 30.1 30 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.23237802035947e-20 7.62466923031099e-19 1.23522997128706 0.730061349693252 30.1 30 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.2460611365952e-13 5.4989821397321e-12 1.23512617044913 0.73 30.1 30 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.06629150482073e-11 2.49576809359021e-10 1.2341309035914 0.729411764705882 30.1 30 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 5.06454441361624e-07 2.82621439238271e-06 1.23371620906734 0.729166666666667 30.1 30 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 2.57657869726318e-08 1.85175327586137e-07 1.23311876780387 0.728813559322034 30.1 30 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.33392830290512e-21 3.08358998751699e-19 1.2314218932094 0.727810650887574 30.1 30 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 8.71780352995795e-08 5.79693197342531e-07 1.23051175138145 0.727272727272727 30.1 30 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 8.71780352995795e-08 5.79693197342531e-07 1.23051175138145 0.727272727272727 30.1 30 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 8.71780352995795e-08 5.79693197342531e-07 1.23051175138145 0.727272727272727 30.1 30 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 8.71780352995795e-08 5.79693197342531e-07 1.23051175138145 0.727272727272727 30.1 30 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 8.71780352995795e-08 5.79693197342531e-07 1.23051175138145 0.727272727272727 30.1 30 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 3.51225646427566e-05 0.000138064667090173 1.23051175138145 0.727272727272727 30.1 30 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000751812773929934 0.00224282930252054 1.23051175138145 0.727272727272727 30.1 30 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.000751812773929934 0.00224282930252054 1.23051175138145 0.727272727272727 30.1 30 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000751812773929934 0.00224282930252054 1.23051175138145 0.727272727272727 30.1 30 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0181320293439227 0.0354908909991775 1.23051175138145 0.727272727272727 30.1 30 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0181320293439227 0.0354908909991775 1.23051175138145 0.727272727272727 30.1 30 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0181320293439227 0.0354908909991775 1.23051175138145 0.727272727272727 30.1 30 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0181320293439227 0.0354908909991775 1.23051175138145 0.727272727272727 30.1 30 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0181320293439227 0.0354908909991775 1.23051175138145 0.727272727272727 30.1 30 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0181320293439227 0.0354908909991775 1.23051175138145 0.727272727272727 30.1 30 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0181320293439227 0.0354908909991775 1.23051175138145 0.727272727272727 30.1 30 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0181320293439227 0.0354908909991775 1.23051175138145 0.727272727272727 30.1 30 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 7.81776367525202e-10 7.22381669472962e-09 1.22840471071128 0.726027397260274 30.1 30 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 7.81776367525202e-10 7.22381669472962e-09 1.22840471071128 0.726027397260274 30.1 30 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 6.68924709830709e-14 1.42071621207328e-12 1.22627833939276 0.724770642201835 30.1 30 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.62714117091973e-09 2.21208395634247e-08 1.22605337547065 0.72463768115942 30.1 30 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.78520757309217e-31 4.65429578942701e-29 1.2252078214186 0.724137931034483 30.1 30 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.10703844891159e-34 2.25045101828742e-32 1.22421220316619 0.723549488054608 30.1 30 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 9.93996835661287e-21 6.4293522597546e-19 1.22417823501405 0.723529411764706 30.1 30 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.53874302712652e-09 1.38584261240572e-08 1.22196653088575 0.722222222222222 30.1 30 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.53874302712652e-09 1.38584261240572e-08 1.22196653088575 0.722222222222222 30.1 30 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 2.02111244045054e-05 8.38496502262718e-05 1.22196653088575 0.722222222222222 30.1 30 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00268475536738529 0.00671424760595654 1.22196653088575 0.722222222222222 30.1 30 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00268475536738529 0.00671424760595654 1.22196653088575 0.722222222222222 30.1 30 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00268475536738529 0.00671424760595654 1.22196653088575 0.722222222222222 30.1 30 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00268475536738529 0.00671424760595654 1.22196653088575 0.722222222222222 30.1 30 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00268475536738529 0.00671424760595654 1.22196653088575 0.722222222222222 30.1 30 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00268475536738529 0.00671424760595654 1.22196653088575 0.722222222222222 30.1 30 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00268475536738529 0.00671424760595654 1.22196653088575 0.722222222222222 30.1 30 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 4.37709176726396e-13 7.2425599823449e-12 1.22015888808858 0.721153846153846 30.1 30 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 4.71501217826379e-11 5.4108567174753e-10 1.21978054424731 0.720930232558139 30.1 30 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 5.81800036920333e-07 3.23399004897513e-06 1.21820663386764 0.72 30.1 30 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000424737546881539 0.00132544195002726 1.21820663386764 0.72 30.1 30 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 3.01327298795616e-09 2.50753652740446e-08 1.21534699388204 0.71830985915493 30.1 30 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 5.26097080057298e-10 5.09276289062268e-09 1.21473595969708 0.717948717948718 30.1 30 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 1.16228879828832e-05 5.01193018170993e-05 1.21473595969708 0.717948717948718 30.1 30 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 9.21325417674789e-11 1.01631478244281e-09 1.2142255664367 0.717647058823529 30.1 30 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 9.21325417674789e-11 1.01631478244281e-09 1.2142255664367 0.717647058823529 30.1 30 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.37569943237222e-21 1.03032646961351e-19 1.21379284171595 0.717391304347826 30.1 30 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.9701463169365e-06 9.31401398339083e-06 1.21379284171595 0.717391304347826 30.1 30 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.37281982900655e-07 1.93529137769206e-06 1.21309884923926 0.716981132075472 30.1 30 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 3.37281982900655e-07 1.93529137769206e-06 1.21309884923926 0.716981132075472 30.1 30 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.92491563409165e-31 4.65429578942701e-29 1.21298148286453 0.716911764705882 30.1 30 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.00882351684388e-08 8.0198651646304e-08 1.21214590434591 0.716417910447761 30.1 30 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.7573331214141e-09 1.54363273566189e-08 1.21180464705302 0.716216216216216 30.1 30 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.7573331214141e-09 1.54363273566189e-08 1.21180464705302 0.716216216216216 30.1 30 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 9.15557620617806e-15 2.50545864257526e-13 1.21050343022078 0.715447154471545 30.1 30 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.79229793075452e-10 1.90331339959977e-09 1.20853832724964 0.714285714285714 30.1 30 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.79229793075452e-10 1.90331339959977e-09 1.20853832724964 0.714285714285714 30.1 30 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.37804067202096e-08 2.40347593814291e-07 1.20853832724964 0.714285714285714 30.1 30 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000240305693990073 0.000808404261342492 1.20853832724964 0.714285714285714 30.1 30 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000240305693990073 0.000808404261342492 1.20853832724964 0.714285714285714 30.1 30 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000240305693990073 0.000808404261342492 1.20853832724964 0.714285714285714 30.1 30 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00149424100090978 0.00408119950920273 1.20853832724964 0.714285714285714 30.1 30 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00975590726556172 0.020566897835399 1.20853832724964 0.714285714285714 30.1 30 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.00975590726556172 0.020566897835399 1.20853832724964 0.714285714285714 30.1 30 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00975590726556172 0.020566897835399 1.20853832724964 0.714285714285714 30.1 30 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00975590726556172 0.020566897835399 1.20853832724964 0.714285714285714 30.1 30 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00975590726556172 0.020566897835399 1.20853832724964 0.714285714285714 30.1 30 1 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0712015005987045 0.112828213086811 1.20853832724964 0.714285714285714 30.1 30 1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0712015005987045 0.112828213086811 1.20853832724964 0.714285714285714 30.1 30 1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_225157.1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE 0.0712015005987045 0.112828213086811 1.20853832724964 0.714285714285714 30.1 30 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0712015005987045 0.112828213086811 1.20853832724964 0.714285714285714 30.1 30 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0712015005987045 0.112828213086811 1.20853832724964 0.714285714285714 30.1 30 1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_216831.1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE 0.0712015005987045 0.112828213086811 1.20853832724964 0.714285714285714 30.1 30 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0712015005987045 0.112828213086811 1.20853832724964 0.714285714285714 30.1 30 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.32265415612984e-20 1.75116180154547e-18 1.20444158715727 0.711864406779661 30.1 30 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.12461969868227e-29 6.70410294709605e-27 1.20389010291407 0.711538461538462 30.1 30 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.54648441815994e-57 2.15654910901387e-54 1.20302408393139 0.711026615969582 30.1 30 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.98350422124953e-09 1.721052748072e-08 1.20217759921149 0.710526315789474 30.1 30 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 6.5474184648667e-08 4.50095481908469e-07 1.20074130578352 0.709677419354839 30.1 30 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 6.5474184648667e-08 4.50095481908469e-07 1.20074130578352 0.709677419354839 30.1 30 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 3.78912873302655e-07 2.13965483614951e-06 1.19974895759692 0.709090909090909 30.1 30 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.1521336032653e-09 1.05773297899775e-08 1.19935955514395 0.708860759493671 30.1 30 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.59427432139956e-09 5.30149850810823e-08 1.19846717452256 0.708333333333333 30.1 30 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000835137270478918 0.00246045618196998 1.19846717452256 0.708333333333333 30.1 30 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000835137270478918 0.00246045618196998 1.19846717452256 0.708333333333333 30.1 30 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000835137270478918 0.00246045618196998 1.19846717452256 0.708333333333333 30.1 30 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000835137270478918 0.00246045618196998 1.19846717452256 0.708333333333333 30.1 30 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000835137270478918 0.00246045618196998 1.19846717452256 0.708333333333333 30.1 30 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 6.68947987830167e-10 6.38867776296864e-09 1.19674770942282 0.707317073170732 30.1 30 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 6.68947987830167e-10 6.38867776296864e-09 1.19674770942282 0.707317073170732 30.1 30 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.18614953795891e-07 1.30709697164518e-06 1.19603620662292 0.706896551724138 30.1 30 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.19110083615922e-08 1.59894178966901e-07 1.194320229282 0.705882352941177 30.1 30 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 7.72694230036895e-05 0.000290884626810186 1.194320229282 0.705882352941177 30.1 30 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 7.72694230036895e-05 0.000290884626810186 1.194320229282 0.705882352941177 30.1 30 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 7.72694230036895e-05 0.000290884626810186 1.194320229282 0.705882352941177 30.1 30 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00531528344814142 0.0120632350027197 1.194320229282 0.705882352941177 30.1 30 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00531528344814142 0.0120632350027197 1.194320229282 0.705882352941177 30.1 30 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00531528344814142 0.0120632350027197 1.194320229282 0.705882352941177 30.1 30 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00531528344814142 0.0120632350027197 1.194320229282 0.705882352941177 30.1 30 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00531528344814142 0.0120632350027197 1.194320229282 0.705882352941177 30.1 30 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00531528344814142 0.0120632350027197 1.194320229282 0.705882352941177 30.1 30 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00531528344814142 0.0120632350027197 1.194320229282 0.705882352941177 30.1 30 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00531528344814142 0.0120632350027197 1.194320229282 0.705882352941177 30.1 30 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.26915773841702e-06 6.20622495452719e-06 1.194320229282 0.705882352941177 30.1 30 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.30775118477428e-14 3.3835089744251e-13 1.19354870458608 0.705426356589147 30.1 30 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 4.7068129008785e-20 2.39206955641075e-18 1.19268864426932 0.704918032786885 30.1 30 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.26118841431736e-07 7.91058521231417e-07 1.19268864426932 0.704918032786885 30.1 30 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.26118841431736e-07 7.91058521231417e-07 1.19268864426932 0.704918032786885 30.1 30 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.28311417722301e-09 1.17043043217201e-08 1.19063405573483 0.703703703703704 30.1 30 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 7.29716606741987e-07 4.0086348900161e-06 1.19063405573483 0.703703703703704 30.1 30 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 7.27550059458537e-08 4.9774218010072e-07 1.18965491588637 0.703125 30.1 30 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.30381905088075e-10 4.25301007597452e-09 1.18631233502436 0.701149425287356 30.1 30 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.30381905088075e-10 4.25301007597452e-09 1.18631233502436 0.701149425287356 30.1 30 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.4212556193365e-08 1.74895773924662e-07 1.18436756070465 0.7 30.1 30 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.41375746704444e-07 1.41348842617458e-06 1.18436756070465 0.7 30.1 30 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 2.49836840125437e-05 0.000102160294108763 1.18436756070465 0.7 30.1 30 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00292250284775358 0.00724515949887343 1.18436756070465 0.7 30.1 30 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.00292250284775358 0.00724515949887343 1.18436756070465 0.7 30.1 30 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0364067126798308 0.0645165032919043 1.18436756070465 0.7 30.1 30 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.83435662661208e-11 5.50343158373519e-10 1.17924042840723 0.696969696969697 30.1 30 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 7.99933650381894e-07 4.32815811594462e-06 1.1783248690684 0.696428571428571 30.1 30 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00161812816217462 0.00440266993264718 1.17701124045183 0.695652173913043 30.1 30 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.58885649427829e-07 2.57084361864488e-06 1.17576440651067 0.694915254237288 30.1 30 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.06804335787643e-16 7.35706424564541e-15 1.17466846330125 0.694267515923567 30.1 30 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 7.46054533721797e-19 3.21707758026096e-17 1.17419734745894 0.693989071038251 30.1 30 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 4.63328337127025e-06 2.09973319659795e-05 1.1740086607568 0.693877551020408 30.1 30 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.000900865209337751 0.00258453869533794 1.17135253256504 0.692307692307692 30.1 30 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.000900865209337751 0.00258453869533794 1.17135253256504 0.692307692307692 30.1 30 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0191970108885016 0.0366184269361096 1.17135253256504 0.692307692307692 30.1 30 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0191970108885016 0.0366184269361096 1.17135253256504 0.692307692307692 30.1 30 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0191970108885016 0.0366184269361096 1.17135253256504 0.692307692307692 30.1 30 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0191970108885016 0.0366184269361096 1.17135253256504 0.692307692307692 30.1 30 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.25573208817157e-16 7.82904088162963e-15 1.17053397733613 0.691823899371069 30.1 30 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.31433804662537e-22 2.774295906087e-20 1.16843436482073 0.690582959641256 30.1 30 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 2.70290804340238e-05 0.000109892518450331 1.16825371634132 0.69047619047619 30.1 30 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 2.70290804340238e-05 0.000109892518450331 1.16825371634132 0.69047619047619 30.1 30 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.30622759309246e-16 2.36290042385695e-14 1.16799381562578 0.690322580645161 30.1 30 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000503777422188771 0.00156522985103629 1.16686459182724 0.689655172413793 30.1 30 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.53637936510093e-05 6.4682480370965e-05 1.1655680756141 0.688888888888889 30.1 30 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 2.84323953180476e-07 1.65139994030946e-06 1.16321813997778 0.6875 30.1 30 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0103156795649306 0.0215553774168813 1.16321813997778 0.6875 30.1 30 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0103156795649306 0.0215553774168813 1.16321813997778 0.6875 30.1 30 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0103156795649306 0.0215553774168813 1.16321813997778 0.6875 30.1 30 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0103156795649306 0.0215553774168813 1.16321813997778 0.6875 30.1 30 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.22820309695659e-12 1.83971895470444e-11 1.15980694308635 0.685483870967742 30.1 30 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.22820309695659e-12 1.83971895470444e-11 1.15980694308635 0.685483870967742 30.1 30 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.22820309695659e-12 1.83971895470444e-11 1.15980694308635 0.685483870967742 30.1 30 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.81030808570195e-09 1.58041006500238e-08 1.15965363086651 0.685393258426966 30.1 30 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.84345670252827e-06 1.3223002900973e-05 1.15930158058392 0.685185185185185 30.1 30 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 8.9860261879801e-05 0.000331272416204551 1.15765250294439 0.684210526315789 30.1 30 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 8.9860261879801e-05 0.000331272416204551 1.15765250294439 0.684210526315789 30.1 30 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 8.9860261879801e-05 0.000331272416204551 1.15765250294439 0.684210526315789 30.1 30 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00561506403281791 0.0126628147681456 1.15765250294439 0.684210526315789 30.1 30 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 5.08382796367159e-05 0.00019711954202465 1.15548054702893 0.682926829268293 30.1 30 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 5.08382796367159e-05 0.00019711954202465 1.15548054702893 0.682926829268293 30.1 30 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.04038293113606e-21 5.44831662428886e-19 1.15360476692011 0.681818181818182 30.1 30 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.74173638888536e-07 1.05467697080164e-06 1.15249017294241 0.681159420289855 30.1 30 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 9.30558400784519e-06 4.03714818389138e-05 1.15052848754166 0.68 30.1 30 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00170723668312334 0.00458376943412172 1.15052848754166 0.68 30.1 30 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00170723668312334 0.00458376943412172 1.15052848754166 0.68 30.1 30 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 7.06328533354559e-11 7.91421655876802e-10 1.14866578626663 0.678899082568807 30.1 30 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.49741467917281e-12 6.3364565232306e-11 1.14616215552063 0.67741935483871 30.1 30 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.000531078162404561 0.00164287875022107 1.14616215552063 0.67741935483871 30.1 30 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.7826008132762e-15 1.64572819145841e-13 1.14581671786074 0.677215189873418 30.1 30 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000297983244330713 0.000986116643447919 1.14455688639525 0.676470588235294 30.1 30 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.9086525020165e-33 5.17376563796185e-31 1.14455688639525 0.676470588235294 30.1 30 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 9.46502540427183e-05 0.000347132246141206 1.14206871925091 0.675 30.1 30 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 9.46502540427183e-05 0.000347132246141206 1.14206871925091 0.675 30.1 30 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 8.26222785024226e-12 1.13049521450911e-10 1.14172482623096 0.67479674796748 30.1 30 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 5.35366836547296e-05 0.000205899191461298 1.14108502526362 0.674418604651163 30.1 30 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 3.03416398540103e-05 0.000122659527023456 1.14022963918771 0.673913043478261 30.1 30 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 9.79436667410536e-06 4.23628686238661e-05 1.13881496221601 0.673076923076923 30.1 30 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 5.55358973448331e-13 8.87950358670758e-12 1.13602602761466 0.671428571428571 30.1 30 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 2.0988944799753e-08 1.53954992010559e-07 1.1346042178179 0.670588235294118 30.1 30 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 2.0988944799753e-08 1.53954992010559e-07 1.1346042178179 0.670588235294118 30.1 30 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 2.0988944799753e-08 1.53954992010559e-07 1.1346042178179 0.670588235294118 30.1 30 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 2.0988944799753e-08 1.53954992010559e-07 1.1346042178179 0.670588235294118 30.1 30 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 2.0988944799753e-08 1.53954992010559e-07 1.1346042178179 0.670588235294118 30.1 30 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.20515999326418e-08 9.32034060008115e-08 1.13437802080478 0.670454545454545 30.1 30 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 2.75660434888937e-11 3.24185784171039e-10 1.13263013479429 0.669421487603306 30.1 30 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.01125855411041e-12 1.56415317662947e-11 1.1320265482583 0.669064748201439 30.1 30 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.09343451559556e-19 9.60953972804027e-18 1.13049818414473 0.668161434977579 30.1 30 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.50896966582658e-10 1.62671502611456e-09 1.127969105433 0.666666666666667 30.1 30 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.5530882443527e-10 4.468306601182e-09 1.127969105433 0.666666666666667 30.1 30 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.53964723695777e-07 2.01476720727636e-06 1.127969105433 0.666666666666667 30.1 30 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.53964723695777e-07 2.01476720727636e-06 1.127969105433 0.666666666666667 30.1 30 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 3.16002448089685e-05 0.000127385689414057 1.127969105433 0.666666666666667 30.1 30 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000174330147094703 0.000606532516664456 1.127969105433 0.666666666666667 30.1 30 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.000309449517649135 0.00102168599446571 1.127969105433 0.666666666666667 30.1 30 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00176572387008268 0.00467900384939972 1.127969105433 0.666666666666667 30.1 30 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00176572387008268 0.00467900384939972 1.127969105433 0.666666666666667 30.1 30 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00176572387008268 0.00467900384939972 1.127969105433 0.666666666666667 30.1 30 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00176572387008268 0.00467900384939972 1.127969105433 0.666666666666667 30.1 30 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00577902654144122 0.01290981910278 1.127969105433 0.666666666666667 30.1 30 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00577902654144122 0.01290981910278 1.127969105433 0.666666666666667 30.1 30 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00577902654144122 0.01290981910278 1.127969105433 0.666666666666667 30.1 30 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0195729845344001 0.0371860573998016 1.127969105433 0.666666666666667 30.1 30 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0367964500879839 0.064883951022554 1.127969105433 0.666666666666667 30.1 30 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0367964500879839 0.064883951022554 1.127969105433 0.666666666666667 30.1 30 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0367964500879839 0.064883951022554 1.127969105433 0.666666666666667 30.1 30 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0708491807218909 0.112828213086811 1.127969105433 0.666666666666667 30.1 30 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.11795034388512e-13 3.96558334124806e-12 1.12425868074408 0.664473684210526 30.1 30 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.91335772435664e-12 2.83615421016614e-11 1.12394064434217 0.664285714285714 30.1 30 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 7.52652846910639e-09 6.01699438850472e-08 1.12203242593072 0.663157894736842 30.1 30 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.30973426165555e-08 9.96658745634144e-08 1.12183883855565 0.66304347826087 30.1 30 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.97096431640137e-08 2.81128468768117e-07 1.12141114551769 0.662790697674419 30.1 30 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.96071295244407e-06 9.30031510442639e-06 1.11929242000659 0.661538461538462 30.1 30 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.11978283780935e-11 3.63889424442844e-10 1.11908745893353 0.661417322834646 30.1 30 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 3.26000660815904e-05 0.000130308691107031 1.11668941437867 0.66 30.1 30 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.10456777471733e-08 2.87724135143979e-07 1.11515127468944 0.659090909090909 30.1 30 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000179144776111436 0.000618220906607163 1.11421338463504 0.658536585365854 30.1 30 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.78697983455557e-07 2.13965483614951e-06 1.1131274066773 0.657894736842105 30.1 30 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00100514795588751 0.00283794750243635 1.11034458816061 0.65625 30.1 30 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.34796703555701e-08 5.00294597684097e-07 1.10852136223588 0.655172413793103 30.1 30 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00179795063485559 0.00474672310463729 1.10852136223588 0.655172413793103 30.1 30 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00179795063485559 0.00474672310463729 1.10852136223588 0.655172413793103 30.1 30 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.79010044544931e-67 3.40815646693719e-64 1.10819136659339 0.654977375565611 30.1 30 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.22856178270717e-07 1.32688009070808e-06 1.10708078866572 0.654320987654321 30.1 30 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.74198702784102e-09 3.87807329920562e-08 1.10627739186698 0.653846153846154 30.1 30 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00323038280027392 0.00788745842745327 1.10627739186698 0.653846153846154 30.1 30 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00323038280027392 0.00788745842745327 1.10627739186698 0.653846153846154 30.1 30 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 7.50027794806091e-13 1.17284566154843e-11 1.10627739186698 0.653846153846154 30.1 30 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.18164168185307e-06 5.85880178842132e-06 1.10446974906981 0.652777777777778 30.1 30 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 5.66280398816751e-15 1.64452450513518e-13 1.10384142403336 0.6524064171123 30.1 30 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.25203590613428e-16 4.56832588315148e-15 1.10379833888801 0.652380952380952 30.1 30 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.000103321856685947 0.000377961444894866 1.10344803792359 0.652173913043478 30.1 30 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00583584075761052 0.0129959333303283 1.10344803792359 0.652173913043478 30.1 30 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.27624280634964e-07 1.34402220474504e-06 1.10078912698883 0.650602409638554 30.1 30 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000322307091334103 0.00105193346552392 1.09976987779717 0.65 30.1 30 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0106155348050802 0.0220846579351303 1.09976987779717 0.65 30.1 30 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00101462037777603 0.00284774121809721 1.0947935435085 0.647058823529412 30.1 30 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00101462037777603 0.00284774121809721 1.0947935435085 0.647058823529412 30.1 30 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0194830724457108 0.037064722045784 1.0947935435085 0.647058823529412 30.1 30 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0194830724457108 0.037064722045784 1.0947935435085 0.647058823529412 30.1 30 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.0190157975872e-09 4.08117684569519e-08 1.09207917935104 0.645454545454546 30.1 30 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.21906854487523e-06 6.0025416586763e-06 1.09086485854376 0.644736842105263 30.1 30 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000324383352636244 0.0010562872100718 1.08768449452468 0.642857142857143 30.1 30 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00323394755118818 0.00788745842745327 1.08768449452468 0.642857142857143 30.1 30 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0361909974097934 0.0645165032919043 1.08768449452468 0.642857142857143 30.1 30 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0361909974097934 0.0645165032919043 1.08768449452468 0.642857142857143 30.1 30 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0361909974097934 0.0645165032919043 1.08768449452468 0.642857142857143 30.1 30 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0361909974097934 0.0645165032919043 1.08768449452468 0.642857142857143 30.1 30 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0361909974097934 0.0645165032919043 1.08768449452468 0.642857142857143 30.1 30 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0361909974097934 0.0645165032919043 1.08768449452468 0.642857142857143 30.1 30 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0361909974097934 0.0645165032919043 1.08768449452468 0.642857142857143 30.1 30 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00580966241213074 0.0129579147530753 1.08285034121568 0.64 30.1 30 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00101435750706127 0.00284774121809721 1.08097039270662 0.638888888888889 30.1 30 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 3.42805081116109e-05 0.000135503230674506 1.0793497474402 0.637931034482759 30.1 30 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 3.42805081116109e-05 0.000135503230674506 1.0793497474402 0.637931034482759 30.1 30 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 3.42805081116109e-05 0.000135503230674506 1.0793497474402 0.637931034482759 30.1 30 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0683874085176697 0.111344716614009 1.07669778245877 0.636363636363636 30.1 30 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.000104805724548138 0.000380455474571429 1.07373982151795 0.634615384615385 30.1 30 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.000104805724548138 0.000380455474571429 1.07373982151795 0.634615384615385 30.1 30 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000570455104386724 0.00175325618475661 1.07294622224115 0.634146341463415 30.1 30 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.54291245193508e-08 1.16167429582202e-07 1.07257776543406 0.633928571428571 30.1 30 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.003203486368629 0.00788678391446206 1.07157065016135 0.633333333333333 30.1 30 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.003203486368629 0.00788678391446206 1.07157065016135 0.633333333333333 30.1 30 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.003203486368629 0.00788678391446206 1.07157065016135 0.633333333333333 30.1 30 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.14207003713461e-06 1.00599526826487e-05 1.07085674566424 0.632911392405063 30.1 30 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0190813834556578 0.0365940817485189 1.06860231041021 0.631578947368421 30.1 30 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0190813834556578 0.0365940817485189 1.06860231041021 0.631578947368421 30.1 30 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0190813834556578 0.0365940817485189 1.06860231041021 0.631578947368421 30.1 30 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.95394890954121e-05 8.17785087728572e-05 1.06723230744815 0.630769230769231 30.1 30 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.93519699381197e-13 5.0322714725234e-12 1.06628329497963 0.630208333333333 30.1 30 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.39579709492067e-49 3.97243853214424e-47 1.06586581281633 0.629961587708067 30.1 30 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000104058555254412 0.000379680318274431 1.06530415513117 0.62962962962963 30.1 30 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.005720302981599 0.0128391027489202 1.06530415513117 0.62962962962963 30.1 30 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.005720302981599 0.0128391027489202 1.06530415513117 0.62962962962963 30.1 30 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.005720302981599 0.0128391027489202 1.06530415513117 0.62962962962963 30.1 30 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.39743814364799e-05 0.00013542169407314 1.0642934301263 0.629032258064516 30.1 30 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000564136633693647 0.00173888891051565 1.06238950627992 0.627906976744186 30.1 30 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000317321155787516 0.00103804139008192 1.05747103634344 0.625 30.1 30 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.010255392111018 0.0215553774168813 1.05747103634344 0.625 30.1 30 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0350018261501826 0.0632879270796821 1.05747103634344 0.625 30.1 30 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0350018261501826 0.0632879270796821 1.05747103634344 0.625 30.1 30 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0350018261501826 0.0632879270796821 1.05747103634344 0.625 30.1 30 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0350018261501826 0.0632879270796821 1.05747103634344 0.625 30.1 30 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 48%5605118 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.132668995156358 0.199143438931959 1.05747103634344 0.625 30.1 30 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 9.62077355296704e-14 1.92821982617917e-12 1.05545680579802 0.623809523809524 30.1 30 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00174255530983767 0.00465226305046716 1.05175497668753 0.621621621621622 30.1 30 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00174255530983767 0.00465226305046716 1.05175497668753 0.621621621621622 30.1 30 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.72652220560002e-17 1.0486057023159e-15 1.05059938339969 0.620938628158845 30.1 30 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 9.61890901984681e-32 1.3687707535242e-29 1.04875779184922 0.619850187265918 30.1 30 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 6.77996745941781e-20 3.32685989474191e-18 1.04838846302515 0.619631901840491 30.1 30 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.18652479910224e-15 3.59239316834572e-14 1.04739988361636 0.619047619047619 30.1 30 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.18652479910224e-15 3.59239316834572e-14 1.04739988361636 0.619047619047619 30.1 30 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.18652479910224e-15 3.59239316834572e-14 1.04739988361636 0.619047619047619 30.1 30 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.8474673015182e-10 1.91893866427767e-09 1.04689632598 0.61875 30.1 30 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.29526799330232e-07 7.91058521231417e-07 1.04593498867424 0.618181818181818 30.1 30 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000175528126378297 0.000609211033747112 1.04593498867424 0.618181818181818 30.1 30 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00306884023862743 0.00759471245142058 1.04503020062175 0.617647058823529 30.1 30 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.72725760260064e-09 2.28287504029454e-08 1.04120225116892 0.615384615384615 30.1 30 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00993650979110169 0.0209166470898487 1.04120225116892 0.615384615384615 30.1 30 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0649555528071555 0.10861545434146 1.04120225116892 0.615384615384615 30.1 30 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0649555528071555 0.10861545434146 1.04120225116892 0.615384615384615 30.1 30 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0649555528071555 0.10861545434146 1.04120225116892 0.615384615384615 30.1 30 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0649555528071555 0.10861545434146 1.04120225116892 0.615384615384615 30.1 30 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00541282814168951 0.01226505484972 1.03700385499486 0.612903225806452 30.1 30 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.13128495620726e-07 1.28366877144634e-06 1.03651215093843 0.612612612612613 30.1 30 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000528631255331957 0.0016388720617372 1.03588999478541 0.612244897959184 30.1 30 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0334793669023719 0.0617113200804084 1.03397167998025 0.611111111111111 30.1 30 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0334793669023719 0.0617113200804084 1.03397167998025 0.611111111111111 30.1 30 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.90197373898223e-06 9.05186832967126e-06 1.03298223339654 0.610526315789474 30.1 30 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.90197373898223e-06 9.05186832967126e-06 1.03298223339654 0.610526315789474 30.1 30 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00164771358354809 0.00444071293444874 1.03167905984726 0.609756097560976 30.1 30 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00164771358354809 0.00444071293444874 1.03167905984726 0.609756097560976 30.1 30 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00164771358354809 0.00444071293444874 1.03167905984726 0.609756097560976 30.1 30 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00164771358354809 0.00444071293444874 1.03167905984726 0.609756097560976 30.1 30 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00164771358354809 0.00444071293444874 1.03167905984726 0.609756097560976 30.1 30 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00091732867778319 0.00262120222587445 1.02988483539535 0.608695652173913 30.1 30 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00091732867778319 0.00262120222587445 1.02988483539535 0.608695652173913 30.1 30 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0177382248084421 0.0351063892940377 1.02988483539535 0.608695652173913 30.1 30 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0177382248084421 0.0351063892940377 1.02988483539535 0.608695652173913 30.1 30 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.009562852283143 0.0203103564162873 1.0272575781622 0.607142857142857 30.1 30 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.009562852283143 0.0203103564162873 1.0272575781622 0.607142857142857 30.1 30 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 3.16101303947556e-06 1.4604290763551e-05 1.02597189909065 0.606382978723404 30.1 30 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00521766346721855 0.0120632350027197 1.02542645948455 0.606060606060606 30.1 30 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00521766346721855 0.0120632350027197 1.02542645948455 0.606060606060606 30.1 30 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 2.31459919925806e-09 1.97226027577498e-08 1.02379361480384 0.605095541401274 30.1 30 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00159154592153878 0.00433863955239404 1.02304174678807 0.604651162790698 30.1 30 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.64241448201699e-06 7.92256206071246e-06 1.0151721948897 0.6 30.1 30 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0611180167228834 0.102924186741613 1.0151721948897 0.6 30.1 30 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.0611180167228834 0.102924186741613 1.0151721948897 0.6 30.1 30 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.87844805029067e-06 1.33421223959727e-05 1.0151721948897 0.6 30.1 30 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 8.55408103707394e-05 0.000318650715072152 1.0151721948897 0.6 30.1 30 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 8.55408103707394e-05 0.000318650715072152 1.0151721948897 0.6 30.1 30 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.000854203821352856 0.00251142983013453 1.0151721948897 0.6 30.1 30 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00500628658038971 0.0116404343200891 1.0151721948897 0.6 30.1 30 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.031780156431524 0.058884326304764 1.0151721948897 0.6 30.1 30 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.031780156431524 0.058884326304764 1.0151721948897 0.6 30.1 30 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.031780156431524 0.058884326304764 1.0151721948897 0.6 30.1 30 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.122512882784981 0.18645543551126 1.0151721948897 0.6 30.1 30 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 3.34596755899795e-09 2.75220337367288e-08 1.01104547865031 0.597560975609756 30.1 30 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.62966939836793e-28 2.67287110991255e-26 1.01043116887737 0.597197898423818 30.1 30 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 5.02766546915645e-75 7.15436796260963e-72 1.00818155356487 0.595868302130407 30.1 30 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00478499428661404 0.0112732564070394 1.00602649944024 0.594594594594595 30.1 30 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 3.16542522387557e-10 3.21742863826781e-09 1.00459748452627 0.59375 30.1 30 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0160691742412873 0.0319363616555194 1.00263920482933 0.592592592592593 30.1 30 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0160691742412873 0.0319363616555194 1.00263920482933 0.592592592592593 30.1 30 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0160691742412873 0.0319363616555194 1.00263920482933 0.592592592592593 30.1 30 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00140581018430341 0.00387687576020107 1.00136032829256 0.591836734693878 30.1 30 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000238061512683848 0.000806575077497893 0.999790797997432 0.590909090909091 30.1 30 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00252473500295783 0.00646168688706653 0.999790797997432 0.590909090909091 30.1 30 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0300037884573669 0.055810968594553 0.999790797997432 0.590909090909091 30.1 30 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0300037884573669 0.055810968594553 0.999790797997432 0.590909090909091 30.1 30 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000422394700701072 0.00132102782219258 0.998530027760361 0.590163934426229 30.1 30 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00828741093663443 0.0178681602467133 0.995266857735 0.588235294117647 30.1 30 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0571714742994282 0.0965065337225223 0.995266857735 0.588235294117647 30.1 30 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0571714742994282 0.0965065337225223 0.995266857735 0.588235294117647 30.1 30 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00433121198376745 0.0102210856598691 0.990411897453366 0.585365853658537 30.1 30 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00127773186334245 0.00356512243438492 0.989633271747821 0.584905660377358 30.1 30 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00228531259258279 0.0059451550626057 0.986972967253875 0.583333333333333 30.1 30 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.0078487206696409 0.0169479962259469 0.986972967253875 0.583333333333333 30.1 30 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.11261475031923 0.173619490470492 0.986972967253875 0.583333333333333 30.1 30 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.11261475031923 0.173619490470492 0.986972967253875 0.583333333333333 30.1 30 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 3.17068844808708e-07 1.83410148846663e-06 0.983973049420277 0.581560283687943 30.1 30 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0143344946577876 0.0289333133305414 0.982424704731968 0.580645161290323 30.1 30 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000106695983056145 0.000383405009820439 0.981750888062056 0.580246913580247 30.1 30 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 9.60430295396263e-07 5.11869779156885e-06 0.981591435262305 0.580152671755725 30.1 30 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 9.60430295396263e-07 5.11869779156885e-06 0.981591435262305 0.580152671755725 30.1 30 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.053276594141604 0.0903606596704439 0.979552117876026 0.578947368421053 30.1 30 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0264523642069588 0.0497248537206109 0.976127110470866 0.576923076923077 30.1 30 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0264523642069588 0.0497248537206109 0.976127110470866 0.576923076923077 30.1 30 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0264523642069588 0.0497248537206109 0.976127110470866 0.576923076923077 30.1 30 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0134857085666363 0.0274145189861763 0.974155136510318 0.575757575757576 30.1 30 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0134857085666363 0.0274145189861763 0.974155136510318 0.575757575757576 30.1 30 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0134857085666363 0.0274145189861763 0.974155136510318 0.575757575757576 30.1 30 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0134857085666363 0.0274145189861763 0.974155136510318 0.575757575757576 30.1 30 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0134857085666363 0.0274145189861763 0.974155136510318 0.575757575757576 30.1 30 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.25561768911849e-07 1.3373933215065e-06 0.97150887467939 0.574193548387097 30.1 30 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 4.3597524992189e-06 2.00126703431887e-05 0.970793082544795 0.573770491803279 30.1 30 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 4.97025713533961e-11 5.61323484411767e-10 0.9687264081954 0.572549019607843 30.1 30 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 7.26497680424064e-20 3.44602066414481e-18 0.967318960113754 0.571717171717172 30.1 30 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00658099047314456 0.0146324210051323 0.966830661799714 0.571428571428571 30.1 30 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0126622434116274 0.025963072586089 0.966830661799714 0.571428571428571 30.1 30 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0247442701854797 0.0466990669415618 0.966830661799714 0.571428571428571 30.1 30 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0247442701854797 0.0466990669415618 0.966830661799714 0.571428571428571 30.1 30 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0495205506955646 0.0866761914388542 0.966830661799714 0.571428571428571 30.1 30 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0495205506955646 0.0866761914388542 0.966830661799714 0.571428571428571 30.1 30 1 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.103308293336972 0.160139108299031 0.966830661799714 0.571428571428571 30.1 30 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.103308293336972 0.160139108299031 0.966830661799714 0.571428571428571 30.1 30 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.103308293336972 0.160139108299031 0.966830661799714 0.571428571428571 30.1 30 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.000266022683982922 0.000890706539547525 0.963771071097816 0.569620253164557 30.1 30 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 7.35547284799703e-05 0.000279115676338661 0.96174207936919 0.568421052631579 30.1 30 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.86090408034727e-24 1.65504156645885e-22 0.960440256958892 0.567651632970451 30.1 30 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0231058488101901 0.0437229027352401 0.95877373961805 0.566666666666667 30.1 30 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000440025019734442 0.00137014355160199 0.95728956974248 0.565789473684211 30.1 30 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0459490212009691 0.0807227866283692 0.956321632867109 0.565217391304348 30.1 30 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.3869059313622e-18 5.80460923626003e-17 0.956022595458457 0.565040650406504 30.1 30 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.58203900175957e-17 2.09032671039576e-15 0.955991753035144 0.565022421524664 30.1 30 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.67311133082578e-36 6.33972903960848e-34 0.955217080276595 0.564564564564565 30.1 30 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00287762541117563 0.00715884783234776 0.953646607320627 0.563636363636364 30.1 30 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00287762541117563 0.00715884783234776 0.953646607320627 0.563636363636364 30.1 30 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00544438732635325 0.0122974018498423 0.951723932709094 0.5625 30.1 30 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00544438732635325 0.0122974018498423 0.951723932709094 0.5625 30.1 30 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0215462919784471 0.0408804979804402 0.951723932709094 0.5625 30.1 30 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0946959760306414 0.147431481281841 0.951723932709094 0.5625 30.1 30 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0946959760306414 0.147431481281841 0.951723932709094 0.5625 30.1 30 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0946959760306414 0.147431481281841 0.951723932709094 0.5625 30.1 30 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0946959760306414 0.147431481281841 0.951723932709094 0.5625 30.1 30 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0946959760306414 0.147431481281841 0.951723932709094 0.5625 30.1 30 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 5.19447215834711e-05 0.000200326276336818 0.948759060644579 0.560747663551402 30.1 30 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0425835410354552 0.0749955184324911 0.94749404856372 0.56 30.1 30 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000564558451622086 0.00173888891051565 0.9399742545275 0.555555555555556 30.1 30 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0867866085457485 0.136461153547625 0.9399742545275 0.555555555555556 30.1 30 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0867866085457485 0.136461153547625 0.9399742545275 0.555555555555556 30.1 30 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0867866085457485 0.136461153547625 0.9399742545275 0.555555555555556 30.1 30 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.209943763199441 0.288926474886659 0.9399742545275 0.555555555555556 30.1 30 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.209943763199441 0.288926474886659 0.9399742545275 0.555555555555556 30.1 30 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.209943763199441 0.288926474886659 0.9399742545275 0.555555555555556 30.1 30 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.209943763199441 0.288926474886659 0.9399742545275 0.555555555555556 30.1 30 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.209943763199441 0.288926474886659 0.9399742545275 0.555555555555556 30.1 30 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.209943763199441 0.288926474886659 0.9399742545275 0.555555555555556 30.1 30 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.209943763199441 0.288926474886659 0.9399742545275 0.555555555555556 30.1 30 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0173724988922557 0.0344784740916037 0.935027021608934 0.552631578947368 30.1 30 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0364911889232949 0.06458577343016 0.933491673461793 0.551724137931034 30.1 30 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0795500180094791 0.125498531737792 0.930574511982225 0.55 30.1 30 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0795500180094791 0.125498531737792 0.930574511982225 0.55 30.1 30 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0729406653814019 0.115327296486372 0.922883813536091 0.545454545454545 30.1 30 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.187463451905755 0.260000479592484 0.922883813536091 0.545454545454545 30.1 30 1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.187463451905755 0.260000479592484 0.922883813536091 0.545454545454545 30.1 30 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.187463451905755 0.260000479592484 0.922883813536091 0.545454545454545 30.1 30 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0025718145647437 0.00655858803876395 0.918489128709729 0.542857142857143 30.1 30 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0103451751924819 0.0215853142212636 0.911051969772808 0.538461538461538 30.1 30 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.061403247335368 0.103282294276866 0.911051969772808 0.538461538461538 30.1 30 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.16821714741665 0.235985358769178 0.911051969772808 0.538461538461538 30.1 30 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.36574146538614e-06 6.65565104535781e-06 0.910391308445924 0.538071065989848 30.1 30 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000796707947174419 0.00237178955822008 0.909652504381452 0.537634408602151 30.1 30 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0228143596758414 0.0432288066827194 0.907877572665585 0.536585365853659 30.1 30 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0563779841393194 0.095393426195305 0.906403745437232 0.535714285714286 30.1 30 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00135590200205485 0.00376110828250301 0.903657067420756 0.534090909090909 30.1 30 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0517887204811288 0.0879419442060219 0.9023752843464 0.533333333333333 30.1 30 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.151525752324501 0.213064373080795 0.9023752843464 0.533333333333333 30.1 30 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.151525752324501 0.213064373080795 0.9023752843464 0.533333333333333 30.1 30 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00659594114793919 0.0146427835468291 0.898850380891922 0.53125 30.1 30 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0131993834599692 0.0270255002353038 0.892121019751555 0.527272727272727 30.1 30 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.124019957883687 0.188547435970605 0.890501925341842 0.526315789473684 30.1 30 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0104563355540177 0.0217853081894102 0.887582246898098 0.524590163934426 30.1 30 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.50669372591921e-06 7.29260262579262e-06 0.885915649331498 0.523605150214592 30.1 30 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00248763000821799 0.00637819369674631 0.88357579925585 0.522222222222222 30.1 30 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.10238609539642 0.159229960381536 0.88275843033887 0.521739130434783 30.1 30 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00171233875930939 0.00458880989547506 0.87981590223774 0.52 30.1 30 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0932602607003008 0.145994885562737 0.87981590223774 0.52 30.1 30 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0932602607003008 0.145994885562737 0.87981590223774 0.52 30.1 30 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0932602607003008 0.145994885562737 0.87981590223774 0.52 30.1 30 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0710227915517802 0.112828213086811 0.873266404206194 0.516129032258065 30.1 30 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0545711233001087 0.0924460814953032 0.868841067698392 0.513513513513513 30.1 30 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0500605330711913 0.0871388285761334 0.867668542640769 0.512820512820513 30.1 30 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0500605330711913 0.0871388285761334 0.867668542640769 0.512820512820513 30.1 30 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0328171581439164 0.0607266788540871 0.863241662321173 0.510204081632653 30.1 30 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.000241916119510964 0.000811902448264391 0.861740372473659 0.509316770186335 30.1 30 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.000312799750626063 0.00102761688991582 0.856420987458389 0.506172839506173 30.1 30 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0467593029846356 0.0820449915501067 0.84597682907475 0.5 30.1 30 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.137863824318258 0.201599347972457 0.84597682907475 0.5 30.1 30 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.262312153492279 0.352474215693591 0.84597682907475 0.5 30.1 30 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.262312153492279 0.352474215693591 0.84597682907475 0.5 30.1 30 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.262312153492279 0.352474215693591 0.84597682907475 0.5 30.1 30 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.262312153492279 0.352474215693591 0.84597682907475 0.5 30.1 30 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0509197403574466 0.0871388285761334 0.84597682907475 0.5 30.1 30 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.103581808974706 0.160388372329713 0.84597682907475 0.5 30.1 30 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.168489897757895 0.235985358769178 0.84597682907475 0.5 30.1 30 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.168489897757895 0.235985358769178 0.84597682907475 0.5 30.1 30 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.187035472410765 0.260000479592484 0.84597682907475 0.5 30.1 30 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.187035472410765 0.260000479592484 0.84597682907475 0.5 30.1 30 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.23312600149633 0.318979134739689 0.84597682907475 0.5 30.1 30 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.23312600149633 0.318979134739689 0.84597682907475 0.5 30.1 30 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.23312600149633 0.318979134739689 0.84597682907475 0.5 30.1 30 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.23312600149633 0.318979134739689 0.84597682907475 0.5 30.1 30 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.23312600149633 0.318979134739689 0.84597682907475 0.5 30.1 30 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.23312600149633 0.318979134739689 0.84597682907475 0.5 30.1 30 1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.297374643613902 0.387512928445588 0.84597682907475 0.5 30.1 30 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.000702778024469957 0.00211427722795084 0.840786787178586 0.496932515337423 30.1 30 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000947903075300113 0.00270313842916245 0.840518914048461 0.496774193548387 30.1 30 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.00272515100511521 0.00680331557943675 0.839315594200146 0.496062992125984 30.1 30 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0138207536180665 0.0279359835206089 0.8360241604974 0.494117647058824 30.1 30 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0138207536180665 0.0279359835206089 0.8360241604974 0.494117647058824 30.1 30 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0334788789431287 0.0617113200804084 0.832548625438643 0.492063492063492 30.1 30 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0429121407717784 0.0754808112710021 0.831135130319053 0.491228070175439 30.1 30 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00139433494110406 0.00385269635182733 0.830015002111075 0.490566037735849 30.1 30 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00139433494110406 0.00385269635182733 0.830015002111075 0.490566037735849 30.1 30 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0714517865993392 0.113098879122202 0.8271773439842 0.488888888888889 30.1 30 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0930361642892914 0.145994885562737 0.824285115508731 0.487179487179487 30.1 30 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.111443189431101 0.172186382801798 0.821806062529757 0.485714285714286 30.1 30 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.134105887808699 0.200876503528188 0.818687253943307 0.483870967741935 30.1 30 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.134105887808699 0.200876503528188 0.818687253943307 0.483870967741935 30.1 30 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.14741543371782 0.208594273110952 0.816805214279069 0.482758620689655 30.1 30 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.179036344580989 0.249773253273281 0.81213775591176 0.48 30.1 30 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.243749435485134 0.328772935256251 0.801451732807658 0.473684210526316 30.1 30 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.243749435485134 0.328772935256251 0.801451732807658 0.473684210526316 30.1 30 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00899821740292747 0.0191970964982995 0.798316162648004 0.471830985915493 30.1 30 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.271861740298452 0.358203015226572 0.796213486188 0.470588235294118 30.1 30 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.169096154292232 0.236601600351864 0.793103277257578 0.46875 30.1 30 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0135555139279839 0.0274779149850729 0.790401708916555 0.467153284671533 30.1 30 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0135555139279839 0.0274779149850729 0.790401708916555 0.467153284671533 30.1 30 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.185769855368045 0.258913324376814 0.7895783738031 0.466666666666667 30.1 30 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.30452621952168 0.396469176925298 0.7895783738031 0.466666666666667 30.1 30 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.122134410800648 0.18645543551126 0.7895783738031 0.466666666666667 30.1 30 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00730922083368672 0.0158640143753861 0.786955189836977 0.465116279069767 30.1 30 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0151119308238697 0.0304593166605758 0.785549912712268 0.464285714285714 30.1 30 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.106353577145792 0.164501239433111 0.783311878772917 0.462962962962963 30.1 30 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.342965015842817 0.434198592121289 0.780901688376692 0.461538461538462 30.1 30 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.342965015842817 0.434198592121289 0.780901688376692 0.461538461538462 30.1 30 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.342965015842817 0.434198592121289 0.780901688376692 0.461538461538462 30.1 30 1 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.342965015842817 0.434198592121289 0.780901688376692 0.461538461538462 30.1 30 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.342965015842817 0.434198592121289 0.780901688376692 0.461538461538462 30.1 30 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.173680905724565 0.242539675020664 0.777384113203824 0.459459459459459 30.1 30 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0025445690039098 0.00650075707821122 0.7763081490333 0.458823529411765 30.1 30 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.14889813952349 0.209784210437551 0.772413626546511 0.456521739130435 30.1 30 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0264956387055205 0.0497404932426857 0.771331814744625 0.455882352941176 30.1 30 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.208199063005224 0.288478351174716 0.769069844613409 0.454545454545455 30.1 30 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.275223756454517 0.36196248191754 0.769069844613409 0.454545454545455 30.1 30 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.388967303370691 0.480052448132258 0.769069844613409 0.454545454545455 30.1 30 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.388967303370691 0.480052448132258 0.769069844613409 0.454545454545455 30.1 30 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.388967303370691 0.480052448132258 0.769069844613409 0.454545454545455 30.1 30 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.388967303370691 0.480052448132258 0.769069844613409 0.454545454545455 30.1 30 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00942893482676197 0.0200858896085064 0.754244401825681 0.44578313253012 30.1 30 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.339722754608603 0.433266071091543 0.751979403622 0.444444444444444 30.1 30 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0634664168155455 0.106626577483496 0.748897520820271 0.442622950819672 30.1 30 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.154283935626849 0.216728569000006 0.748897520820271 0.442622950819672 30.1 30 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.274377039428929 0.361182726278784 0.740229725440406 0.4375 30.1 30 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.379325645779818 0.47019198078805 0.740229725440406 0.4375 30.1 30 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.369833336637898 0.46167019111304 0.725122996349786 0.428571428571429 30.1 30 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.425344276602684 0.5164376327693 0.725122996349786 0.428571428571429 30.1 30 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.425344276602684 0.5164376327693 0.725122996349786 0.428571428571429 30.1 30 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0688025820522596 0.111892656297561 0.722509940507084 0.427027027027027 30.1 30 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.323139758899027 0.412771882327932 0.717798521639182 0.424242424242424 30.1 30 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.360821618285563 0.456399255840317 0.715826547678635 0.423076923076923 30.1 30 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.173356399037016 0.242324318103806 0.715155669939479 0.422680412371134 30.1 30 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.235721013593646 0.319854090056473 0.711110957772978 0.420289855072464 30.1 30 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.396110732870395 0.482896690151797 0.704980690895625 0.416666666666667 30.1 30 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.479435267569557 0.566171274482556 0.704980690895625 0.416666666666667 30.1 30 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.479435267569557 0.566171274482556 0.704980690895625 0.416666666666667 30.1 30 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.384320178919101 0.475968332986842 0.700118755096345 0.413793103448276 30.1 30 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.373713868581184 0.463639786391478 0.6966868004145 0.411764705882353 30.1 30 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.454550379616774 0.548621874635004 0.6966868004145 0.411764705882353 30.1 30 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.372385873866101 0.462395373919251 0.683981266060436 0.404255319148936 30.1 30 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.278261593688389 0.365619804079942 0.683288977329606 0.403846153846154 30.1 30 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.440319802505025 0.534164602697912 0.6767814632598 0.4 30.1 30 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.478985606322686 0.566171274482556 0.6767814632598 0.4 30.1 30 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.40433057065187 0.491762736784282 0.67039673247433 0.39622641509434 30.1 30 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0106672608482108 0.0221598718058452 0.6693533740289 0.395609756097561 30.1 30 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.459290934626884 0.553873728791572 0.666527198664955 0.393939393939394 30.1 30 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.477889834162743 0.565754770393996 0.664696079987304 0.392857142857143 30.1 30 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.390567905393235 0.48161016410275 0.663931182311829 0.392405063291139 30.1 30 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.39670149739104 0.482896690151797 0.649957807703771 0.384146341463415 30.1 30 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.51645251107435 0.608673515884887 0.638473078546981 0.377358490566038 30.1 30 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.562376237877857 0.659737334295294 0.634482621806063 0.375 30.1 30 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.58182804931614 0.681433180392483 0.634482621806063 0.375 30.1 30 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.554040173486832 0.650494362105415 0.629564151869581 0.372093023255814 30.1 30 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.576841570456544 0.676149550872868 0.626649503018333 0.37037037037037 30.1 30 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.596514738562243 0.693129607668026 0.623351347739289 0.368421052631579 30.1 30 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.621158634700767 0.701703115191321 0.60910331693382 0.36 30.1 30 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.642165229507704 0.721232140165322 0.604269163624822 0.357142857142857 30.1 30 1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.642165229507704 0.721232140165322 0.604269163624822 0.357142857142857 30.1 30 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.706188211644068 0.790641876608583 0.600370652891758 0.354838709677419 30.1 30 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.651252232788521 0.730861141370714 0.597160114641 0.352941176470588 30.1 30 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.659799655922004 0.739869905734445 0.592183780352325 0.35 30.1 30 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.689137139107874 0.772159172401973 0.587004330378398 0.346938775510204 30.1 30 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.750909824717504 0.826022402483395 0.581074993707909 0.343434343434343 30.1 30 1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.710303020266547 0.79269727811442 0.5639845527165 0.333333333333333 30.1 30 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.716621366972498 0.798553018952125 0.5639845527165 0.333333333333333 30.1 30 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.770796905600915 0.846330244344215 0.545791502628871 0.32258064516129 30.1 30 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.808264260154379 0.883379448694072 0.531756863989843 0.314285714285714 30.1 30 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.927656620291219 0.99626820428257 0.500436997480838 0.295774647887324 30.1 30 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999960737717979 1 0.470956172886974 0.278350515463918 30.1 30 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.857857038097495 0.929018694986861 0.46998712726375 0.277777777777778 30.1 30 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.942726529405453 1 0.445250962670921 0.263157894736842 30.1 30 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.935814698205438 1 0.436633202103097 0.258064516129032 30.1 30 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999982950269289 1 0.435073797809871 0.257142857142857 30.1 30 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999886170461569 1 0.413375041479707 0.244318181818182 30.1 30 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999988517853083 1 0.40544511623859 0.23963133640553 30.1 30 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.952326556542588 1 0.384534922306705 0.227272727272727 30.1 30 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.952326556542588 1 0.384534922306705 0.227272727272727 30.1 30 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.97285895365371 1 0.38205405184021 0.225806451612903 30.1 30 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.97285895365371 1 0.38205405184021 0.225806451612903 30.1 30 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.33526537642593 0.198152812762385 30.1 30 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999979753718527 1 0.328990989084625 0.194444444444444 30.1 30 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.997269899669902 1 0.290049198539914 0.171428571428571 30.1 30 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.996136019805598 1 0.28199227635825 0.166666666666667 30.1 30 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999476173910098 1 0.28199227635825 0.166666666666667 30.1 30 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.279952549223651 0.165461121157324 30.1 30 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.999860538553667 1 0.246743241813469 0.145833333333333 30.1 30 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.99999954528991 1 0.24439330617715 0.144444444444444 30.1 30 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00114311083921762 0.00315020486602559 1.12237237237237 1 30.2 30 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00114311083921762 0.00315020486602559 1.12237237237237 1 30.2 30 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00114311083921762 0.00315020486602559 1.12237237237237 1 30.2 30 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.00114311083921762 0.00315020486602559 1.12237237237237 1 30.2 30 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00114311083921762 0.00315020486602559 1.12237237237237 1 30.2 30 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00114311083921762 0.00315020486602559 1.12237237237237 1 30.2 30 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00114311083921762 0.00315020486602559 1.12237237237237 1 30.2 30 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 6.68569542585414e-09 5.73117144035569e-08 1.12237237237237 1 30.2 30 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 5.62598062609999e-05 0.000207942089115332 1.12237237237237 1 30.2 30 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000119451699844918 0.000413576079998342 1.12237237237237 1 30.2 30 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000119451699844918 0.000413576079998342 1.12237237237237 1 30.2 30 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000253613316023333 0.000839283136514426 1.12237237237237 1 30.2 30 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.000538440090122407 0.00164068575641153 1.12237237237237 1 30.2 30 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000538440090122407 0.00164068575641153 1.12237237237237 1 30.2 30 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000538440090122407 0.00164068575641153 1.12237237237237 1 30.2 30 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00242674932541968 0.00609041321000388 1.12237237237237 1 30.2 30 2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0109359101353609 0.0227844804137899 1.12237237237237 1 30.2 30 2 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0109359101353609 0.0227844804137899 1.12237237237237 1 30.2 30 2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0109359101353609 0.0227844804137899 1.12237237237237 1 30.2 30 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0109359101353609 0.0227844804137899 1.12237237237237 1 30.2 30 2 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.0109359101353609 0.0227844804137899 1.12237237237237 1 30.2 30 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0109359101353609 0.0227844804137899 1.12237237237237 1 30.2 30 2 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0109359101353609 0.0227844804137899 1.12237237237237 1 30.2 30 2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 G2 M DNA REPLICATION CHECKPOINT%REACTOME%REACT_223573.1 G2 M DNA REPLICATION CHECKPOINT 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604677 HISTIDINE CATABOLISM 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.0232139142550413 0.0433509186153855 1.12237237237237 1 30.2 30 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 2.64965753234771e-05 0.000104735074125855 1.12237237237237 1 30.2 30 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00515165906429612 0.0118621534765265 1.12237237237237 1 30.2 30 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00515165906429612 0.0118621534765265 1.12237237237237 1 30.2 30 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00515165906429612 0.0118621534765265 1.12237237237237 1 30.2 30 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00515165906429612 0.0118621534765265 1.12237237237237 1 30.2 30 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00515165906429612 0.0118621534765265 1.12237237237237 1 30.2 30 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 8.09864628660756e-07 4.28415377912363e-06 1.07357357357357 0.956521739130435 30.2 30 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 3.34696403372905e-06 1.56155076065457e-05 1.06892606892607 0.952380952380952 30.2 30 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 6.78307722614809e-06 3.00695292610864e-05 1.06625375375375 0.95 30.2 30 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 1.3714874958328e-05 5.7911771708311e-05 1.06330014224751 0.947368421052632 30.2 30 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.40886447905242e-09 1.39223205117472e-08 1.06001835168502 0.944444444444444 30.2 30 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.40886447905242e-09 1.39223205117472e-08 1.06001835168502 0.944444444444444 30.2 30 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 2.76594476064283e-05 0.000107833956010815 1.06001835168502 0.944444444444444 30.2 30 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 2.76594476064283e-05 0.000107833956010815 1.06001835168502 0.944444444444444 30.2 30 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 2.76594476064283e-05 0.000107833956010815 1.06001835168502 0.944444444444444 30.2 30 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 2.76594476064283e-05 0.000107833956010815 1.06001835168502 0.944444444444444 30.2 30 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 2.76594476064283e-05 0.000107833956010815 1.06001835168502 0.944444444444444 30.2 30 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 5.56239862792955e-05 0.000206127428321452 1.05635046811517 0.941176470588235 30.2 30 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 5.56239862792955e-05 0.000206127428321452 1.05635046811517 0.941176470588235 30.2 30 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 5.56239862792955e-05 0.000206127428321452 1.05635046811517 0.941176470588235 30.2 30 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 5.56239862792955e-05 0.000206127428321452 1.05635046811517 0.941176470588235 30.2 30 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.58948426401726e-12 5.41887662896553e-11 1.05365569651284 0.938775510204082 30.2 30 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00011150835711726 0.000388912725926129 1.0522240990991 0.9375 30.2 30 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00011150835711726 0.000388912725926129 1.0522240990991 0.9375 30.2 30 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00011150835711726 0.000388912725926129 1.0522240990991 0.9375 30.2 30 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00011150835711726 0.000388912725926129 1.0522240990991 0.9375 30.2 30 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00011150835711726 0.000388912725926129 1.0522240990991 0.9375 30.2 30 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00011150835711726 0.000388912725926129 1.0522240990991 0.9375 30.2 30 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00011150835711726 0.000388912725926129 1.0522240990991 0.9375 30.2 30 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000222747824460738 0.000742318862312951 1.04754754754755 0.933333333333333 30.2 30 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000222747824460738 0.000742318862312951 1.04754754754755 0.933333333333333 30.2 30 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.000222747824460738 0.000742318862312951 1.04754754754755 0.933333333333333 30.2 30 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.000222747824460738 0.000742318862312951 1.04754754754755 0.933333333333333 30.2 30 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000222747824460738 0.000742318862312951 1.04754754754755 0.933333333333333 30.2 30 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000222747824460738 0.000742318862312951 1.04754754754755 0.933333333333333 30.2 30 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000443181808448798 0.00141084499647123 1.04220291720292 0.928571428571429 30.2 30 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.000877754422851938 0.00255951750761948 1.03603603603604 0.923076923076923 30.2 30 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000877754422851938 0.00255951750761948 1.03603603603604 0.923076923076923 30.2 30 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.000877754422851938 0.00255951750761948 1.03603603603604 0.923076923076923 30.2 30 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.000877754422851938 0.00255951750761948 1.03603603603604 0.923076923076923 30.2 30 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 4.81495721774613e-09 4.28230257553297e-08 1.03376402718508 0.921052631578947 30.2 30 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.72849911952295e-06 1.29854657093015e-05 1.03258258258258 0.92 30.2 30 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.72849911952295e-06 1.29854657093015e-05 1.03258258258258 0.92 30.2 30 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 2.72849911952295e-06 1.29854657093015e-05 1.03258258258258 0.92 30.2 30 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 2.72849911952295e-06 1.29854657093015e-05 1.03258258258258 0.92 30.2 30 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.72849911952295e-06 1.29854657093015e-05 1.03258258258258 0.92 30.2 30 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 2.72849911952295e-06 1.29854657093015e-05 1.03258258258258 0.92 30.2 30 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 5.34831075818366e-06 2.40843234458713e-05 1.02884134134134 0.916666666666667 30.2 30 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0017293910939859 0.00453208752622825 1.02884134134134 0.916666666666667 30.2 30 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.30654127729095e-10 2.18730380892356e-09 1.02685131940451 0.914893617021277 30.2 30 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.04482698304997e-05 4.54675473052021e-05 1.02477477477477 0.91304347826087 30.2 30 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 7.02362766741336e-08 4.56375441585809e-07 1.02333951598657 0.911764705882353 30.2 30 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 7.02362766741336e-08 4.56375441585809e-07 1.02333951598657 0.911764705882353 30.2 30 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 3.57701356365907e-12 7.27155757298123e-11 1.02216055341055 0.910714285714286 30.2 30 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 1.36412340223226e-07 8.36701552317461e-07 1.02033852033852 0.909090909090909 30.2 30 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 2.03367361697694e-05 8.24477936455324e-05 1.02033852033852 0.909090909090909 30.2 30 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 2.03367361697694e-05 8.24477936455324e-05 1.02033852033852 0.909090909090909 30.2 30 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 2.03367361697694e-05 8.24477936455324e-05 1.02033852033852 0.909090909090909 30.2 30 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.00338670783111314 0.00807250459576885 1.02033852033852 0.909090909090909 30.2 30 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00338670783111314 0.00807250459576885 1.02033852033852 0.909090909090909 30.2 30 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00338670783111314 0.00807250459576885 1.02033852033852 0.909090909090909 30.2 30 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00338670783111314 0.00807250459576885 1.02033852033852 0.909090909090909 30.2 30 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00338670783111314 0.00807250459576885 1.02033852033852 0.909090909090909 30.2 30 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00338670783111314 0.00807250459576885 1.02033852033852 0.909090909090909 30.2 30 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00338670783111314 0.00807250459576885 1.02033852033852 0.909090909090909 30.2 30 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.04133138042315e-17 7.64424882721617e-16 1.01673732556085 0.905882352941176 30.2 30 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 3.94261525541286e-05 0.000152041775296816 1.01547976547977 0.904761904761905 30.2 30 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 5.10191780045304e-07 2.80310001160026e-06 1.01375569117505 0.903225806451613 30.2 30 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 9.82115833413679e-07 5.13805452554289e-06 1.01013513513514 0.9 30.2 30 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 7.61010545479477e-05 0.00027625459342278 1.01013513513514 0.9 30.2 30 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 7.61010545479477e-05 0.00027625459342278 1.01013513513514 0.9 30.2 30 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 7.61010545479477e-05 0.00027625459342278 1.01013513513514 0.9 30.2 30 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00658514758107452 0.0144832534897512 1.01013513513514 0.9 30.2 30 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00014618831511528 0.000503694848448047 1.00422791212265 0.894736842105263 30.2 30 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.76805396329895e-07 1.04395883393129e-06 0.997664330997664 0.888888888888889 30.2 30 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000279340295662236 0.000905469796645471 0.997664330997664 0.888888888888889 30.2 30 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000279340295662236 0.000905469796645471 0.997664330997664 0.888888888888889 30.2 30 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.000279340295662236 0.000905469796645471 0.997664330997664 0.888888888888889 30.2 30 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000279340295662236 0.000905469796645471 0.997664330997664 0.888888888888889 30.2 30 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0126958572150361 0.0258088640242806 0.997664330997664 0.888888888888889 30.2 30 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0126958572150361 0.0258088640242806 0.997664330997664 0.888888888888889 30.2 30 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 4.68205258440101e-09 4.19028982868091e-08 0.997664330997664 0.888888888888889 30.2 30 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 4.68205258440101e-09 4.19028982868091e-08 0.997664330997664 0.888888888888889 30.2 30 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 6.85932257607266e-06 3.01259753881216e-05 0.997664330997664 0.888888888888889 30.2 30 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 6.85932257607266e-06 3.01259753881216e-05 0.997664330997664 0.888888888888889 30.2 30 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 6.85932257607266e-06 3.01259753881216e-05 0.997664330997664 0.888888888888889 30.2 30 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.43502907344149e-12 7.08412517609745e-11 0.997664330997664 0.888888888888889 30.2 30 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 8.868545255505e-09 7.51186898725215e-08 0.994830057330057 0.886363636363636 30.2 30 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 1.30084074197438e-05 5.52566082337176e-05 0.992867867867868 0.884615384615385 30.2 30 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.30084074197438e-05 5.52566082337176e-05 0.992867867867868 0.884615384615385 30.2 30 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 1.30084074197438e-05 5.52566082337176e-05 0.992867867867868 0.884615384615385 30.2 30 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 1.30084074197438e-05 5.52566082337176e-05 0.992867867867868 0.884615384615385 30.2 30 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.000530641138401993 0.00162737573264232 0.990328563857976 0.882352941176471 30.2 30 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000530641138401993 0.00162737573264232 0.990328563857976 0.882352941176471 30.2 30 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.50495280621481e-10 1.0616270037933e-08 0.990328563857976 0.882352941176471 30.2 30 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.50495280621481e-10 1.0616270037933e-08 0.990328563857976 0.882352941176471 30.2 30 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.19067728996107e-06 6.0947258403403e-06 0.986327236327236 0.878787878787879 30.2 30 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 1.19067728996107e-06 6.0947258403403e-06 0.986327236327236 0.878787878787879 30.2 30 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 1.19067728996107e-06 6.0947258403403e-06 0.986327236327236 0.878787878787879 30.2 30 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 2.99918250037357e-09 2.86431993156483e-08 0.984939020653306 0.877551020408163 30.2 30 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.48062178958467e-11 2.77226948234077e-10 0.982075825825826 0.875 30.2 30 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 4.61479833367125e-05 0.000175584439273107 0.982075825825826 0.875 30.2 30 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 4.61479833367125e-05 0.000175584439273107 0.982075825825826 0.875 30.2 30 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 4.61479833367125e-05 0.000175584439273107 0.982075825825826 0.875 30.2 30 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00100142409586508 0.00283014147739849 0.982075825825826 0.875 30.2 30 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00100142409586508 0.00283014147739849 0.982075825825826 0.875 30.2 30 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00100142409586508 0.00283014147739849 0.982075825825826 0.875 30.2 30 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00100142409586508 0.00283014147739849 0.982075825825826 0.875 30.2 30 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00100142409586508 0.00283014147739849 0.982075825825826 0.875 30.2 30 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00100142409586508 0.00283014147739849 0.982075825825826 0.875 30.2 30 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00100142409586508 0.00283014147739849 0.982075825825826 0.875 30.2 30 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0242260272364313 0.0446549698930592 0.982075825825826 0.875 30.2 30 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.04634319121554e-08 8.65666489011459e-08 0.97909079292058 0.872340425531915 30.2 30 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 7.27994131312913e-15 2.15819926845474e-13 0.978813115441022 0.872093023255814 30.2 30 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.94597081322519e-08 1.58235226698254e-07 0.975975975975976 0.869565217391304 30.2 30 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 8.62598450982341e-05 0.000309188311271504 0.975975975975976 0.869565217391304 30.2 30 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.02886923189736e-26 4.77072061132663e-24 0.975060998498499 0.86875 30.2 30 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00187600270437119 0.00485929474472469 0.972722722722723 0.866666666666667 30.2 30 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00187600270437119 0.00485929474472469 0.972722722722723 0.866666666666667 30.2 30 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00187600270437119 0.00485929474472469 0.972722722722723 0.866666666666667 30.2 30 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00187600270437119 0.00485929474472469 0.972722722722723 0.866666666666667 30.2 30 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00016032578965507 0.000545798082964509 0.969321594321594 0.863636363636364 30.2 30 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00016032578965507 0.000545798082964509 0.969321594321594 0.863636363636364 30.2 30 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00016032578965507 0.000545798082964509 0.969321594321594 0.863636363636364 30.2 30 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.43380368289108e-05 5.98329220162465e-05 0.967562389976183 0.862068965517241 30.2 30 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.43380368289108e-05 5.98329220162465e-05 0.967562389976183 0.862068965517241 30.2 30 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 2.25492062153439e-07 1.28865543953552e-06 0.962033462033462 0.857142857142857 30.2 30 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000296150466510862 0.000947015986168442 0.962033462033462 0.857142857142857 30.2 30 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000296150466510862 0.000947015986168442 0.962033462033462 0.857142857142857 30.2 30 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000296150466510862 0.000947015986168442 0.962033462033462 0.857142857142857 30.2 30 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.93891209794673e-10 2.90286948363001e-09 0.962033462033462 0.857142857142857 30.2 30 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 2.64033063071223e-05 0.000104657116643551 0.962033462033462 0.857142857142857 30.2 30 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.64033063071223e-05 0.000104657116643551 0.962033462033462 0.857142857142857 30.2 30 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 2.64033063071223e-05 0.000104657116643551 0.962033462033462 0.857142857142857 30.2 30 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00348519010927076 0.00826570920915381 0.962033462033462 0.857142857142857 30.2 30 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00348519010927076 0.00826570920915381 0.962033462033462 0.857142857142857 30.2 30 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00348519010927076 0.00826570920915381 0.962033462033462 0.857142857142857 30.2 30 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0456414165617493 0.0777817194818793 0.962033462033462 0.857142857142857 30.2 30 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.24754992112679e-17 1.73657291575894e-15 0.959118209118209 0.854545454545454 30.2 30 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.12412365501106e-07 2.29243279729716e-06 0.958122756903245 0.853658536585366 30.2 30 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.12412365501106e-07 2.29243279729716e-06 0.958122756903245 0.853658536585366 30.2 30 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.63065029234899e-19 8.59413098523192e-18 0.957061712875666 0.852713178294574 30.2 30 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.8365645270853e-05 0.000181663229985185 0.956094983872762 0.851851851851852 30.2 30 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 4.8365645270853e-05 0.000181663229985185 0.956094983872762 0.851851851851852 30.2 30 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.17385358746394e-09 1.17633355983182e-08 0.954016516516517 0.85 30.2 30 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.17385358746394e-09 1.17633355983182e-08 0.954016516516517 0.85 30.2 30 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.17385358746394e-09 1.17633355983182e-08 0.954016516516517 0.85 30.2 30 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.17385358746394e-09 1.17633355983182e-08 0.954016516516517 0.85 30.2 30 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.17385358746394e-09 1.17633355983182e-08 0.954016516516517 0.85 30.2 30 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.17385358746394e-09 1.17633355983182e-08 0.954016516516517 0.85 30.2 30 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.17385358746394e-09 1.17633355983182e-08 0.954016516516517 0.85 30.2 30 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 7.51382810246904e-07 4.00041917577558e-06 0.954016516516517 0.85 30.2 30 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000543349458330162 0.00164507718979536 0.954016516516517 0.85 30.2 30 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000543349458330162 0.00164507718979536 0.954016516516517 0.85 30.2 30 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000543349458330162 0.00164507718979536 0.954016516516517 0.85 30.2 30 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 8.06419932576505e-06 3.52004774250419e-05 0.952315952315952 0.848484848484849 30.2 30 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.28683681893641e-07 7.92713763353467e-07 0.951576576576577 0.847826086956522 30.2 30 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 8.80954672290973e-05 0.000314185087385979 0.9496996996997 0.846153846153846 30.2 30 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 8.80954672290973e-05 0.000314185087385979 0.9496996996997 0.846153846153846 30.2 30 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00641339278522274 0.0143720597375936 0.9496996996997 0.846153846153846 30.2 30 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00641339278522274 0.0143720597375936 0.9496996996997 0.846153846153846 30.2 30 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00641339278522274 0.0143720597375936 0.9496996996997 0.846153846153846 30.2 30 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00641339278522274 0.0143720597375936 0.9496996996997 0.846153846153846 30.2 30 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00641339278522274 0.0143720597375936 0.9496996996997 0.846153846153846 30.2 30 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00641339278522274 0.0143720597375936 0.9496996996997 0.846153846153846 30.2 30 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 4.70454847636502e-38 9.56367497409632e-36 0.949064873697227 0.845588235294118 30.2 30 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.84587799680836e-09 3.50813101888352e-08 0.948211142176659 0.844827586206897 30.2 30 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.84587799680836e-09 3.50813101888352e-08 0.948211142176659 0.844827586206897 30.2 30 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 1.46192123170048e-05 6.06505513909557e-05 0.947001689189189 0.84375 30.2 30 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000989484191912664 0.00283014147739849 0.945155681997787 0.842105263157895 30.2 30 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000989484191912664 0.00283014147739849 0.945155681997787 0.842105263157895 30.2 30 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.000989484191912664 0.00283014147739849 0.945155681997787 0.842105263157895 30.2 30 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000989484191912664 0.00283014147739849 0.945155681997787 0.842105263157895 30.2 30 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.000989484191912664 0.00283014147739849 0.945155681997787 0.842105263157895 30.2 30 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.1011634350941e-10 2.90286948363001e-09 0.943443443443443 0.840579710144927 30.2 30 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 7.20623634217639e-08 4.64003362665928e-07 0.942792792792793 0.84 30.2 30 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 7.20623634217639e-08 4.64003362665928e-07 0.942792792792793 0.84 30.2 30 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.000159483516285551 0.000545798082964509 0.942792792792793 0.84 30.2 30 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000159483516285551 0.000545798082964509 0.942792792792793 0.84 30.2 30 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 2.63656473105731e-05 0.000104657116643551 0.941344570376829 0.838709677419355 30.2 30 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4.43129247835226e-06 2.01460996699529e-05 0.940366041717393 0.837837837837838 30.2 30 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 7.53416963533279e-07 4.00041917577558e-06 0.939660590823381 0.837209302325581 30.2 30 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.09680831379033e-10 2.90286948363001e-09 0.935310310310311 0.833333333333333 30.2 30 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 7.9331383430884e-06 3.47349411145071e-05 0.935310310310311 0.833333333333333 30.2 30 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00178714535210078 0.00467483058095479 0.935310310310311 0.833333333333333 30.2 30 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 4.72885565238239e-05 0.000178967063652663 0.93531031031031 0.833333333333333 30.2 30 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.72885565238239e-05 0.000178967063652663 0.93531031031031 0.833333333333333 30.2 30 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.13331011220718e-12 2.40701535771764e-11 0.93531031031031 0.833333333333333 30.2 30 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000286819153905844 0.000923401936669721 0.93531031031031 0.833333333333333 30.2 30 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000286819153905844 0.000923401936669721 0.93531031031031 0.833333333333333 30.2 30 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000286819153905844 0.000923401936669721 0.93531031031031 0.833333333333333 30.2 30 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0116732915167494 0.0240392095923797 0.93531031031031 0.833333333333333 30.2 30 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0116732915167494 0.0240392095923797 0.93531031031031 0.833333333333333 30.2 30 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0116732915167494 0.0240392095923797 0.93531031031031 0.833333333333333 30.2 30 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0116732915167494 0.0240392095923797 0.93531031031031 0.833333333333333 30.2 30 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0116732915167494 0.0240392095923797 0.93531031031031 0.833333333333333 30.2 30 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0116732915167494 0.0240392095923797 0.93531031031031 0.833333333333333 30.2 30 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_223937.1 FGFR2B LIGAND BINDING AND ACTIVATION 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605630 MULTIFUNCTIONAL ANION EXCHANGERS 0.0846039348534437 0.12973211131083 0.93531031031031 0.833333333333333 30.2 30 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.3978106847265e-06 1.1645339946641e-05 0.930747820991724 0.829268292682927 30.2 30 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.3978106847265e-06 1.1645339946641e-05 0.930747820991724 0.829268292682927 30.2 30 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 1.41313287047397e-05 5.93182322915771e-05 0.92996567996568 0.828571428571429 30.2 30 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 1.41313287047397e-05 5.93182322915771e-05 0.92996567996568 0.828571428571429 30.2 30 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 7.27500213759435e-07 3.89185264729201e-06 0.927177177177177 0.826086956521739 30.2 30 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.000512139026300035 0.00157743254204535 0.927177177177177 0.826086956521739 30.2 30 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000512139026300035 0.00157743254204535 0.927177177177177 0.826086956521739 30.2 30 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000512139026300035 0.00157743254204535 0.927177177177177 0.826086956521739 30.2 30 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.32257602125738e-17 1.18200641956231e-15 0.926807489307489 0.825757575757576 30.2 30 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 6.3367341602332e-11 1.09965520853803e-09 0.925957207207207 0.825 30.2 30 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 4.24881633158519e-06 1.94407255300506e-05 0.925957207207207 0.825 30.2 30 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.78083150671768e-21 1.20672534955203e-19 0.924306659600777 0.823529411764706 30.2 30 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 2.50389384204118e-05 0.000100367350344355 0.924306659600777 0.823529411764706 30.2 30 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00319841123069283 0.00775355908224173 0.924306659600777 0.823529411764706 30.2 30 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.21431105324265e-07 1.27055025353399e-06 0.924306659600777 0.823529411764706 30.2 30 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 5.20623315002435e-32 6.73497252044058e-30 0.923798798798799 0.823076923076923 30.2 30 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.12936968290226e-21 2.02413320853178e-19 0.923134673134673 0.822485207100592 30.2 30 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.91606821461599e-14 1.5306481944361e-12 0.923072605315596 0.822429906542056 30.2 30 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.34421812173728e-10 8.06055570288584e-09 0.92249784030606 0.821917808219178 30.2 30 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.61689545592268e-09 3.34210534660907e-08 0.921350454932545 0.82089552238806 30.2 30 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 3.61689545592268e-09 3.34210534660907e-08 0.921350454932545 0.82089552238806 30.2 30 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 3.61689545592268e-09 3.34210534660907e-08 0.921350454932545 0.82089552238806 30.2 30 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.75435762981347e-17 6.80535948633407e-16 0.920506837773025 0.820143884892086 30.2 30 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.66849180886641e-22 1.24961254948258e-20 0.919977354403584 0.819672131147541 30.2 30 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.1125588019826e-09 1.17271938905277e-08 0.919721805138472 0.819444444444444 30.2 30 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.60614963521927e-25 1.42846933182313e-23 0.919276419276419 0.819047619047619 30.2 30 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.02401920047513e-12 2.24181434196324e-11 0.918304668304668 0.818181818181818 30.2 30 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.25533884462859e-06 1.10667143996775e-05 0.918304668304668 0.818181818181818 30.2 30 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.25533884462859e-06 1.10667143996775e-05 0.918304668304668 0.818181818181818 30.2 30 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000907361512361928 0.00263505190222658 0.918304668304668 0.818181818181818 30.2 30 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000907361512361928 0.00263505190222658 0.918304668304668 0.818181818181818 30.2 30 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0209781264559007 0.0403403701983063 0.918304668304668 0.818181818181818 30.2 30 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.05638749988924e-10 1.81113182209927e-09 0.917060353035963 0.817073170731707 30.2 30 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 3.6171542598449e-08 2.68083880820797e-07 0.916604104104104 0.816666666666667 30.2 30 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.86100054623546e-31 9.32183648107755e-29 0.915959062510787 0.816091954022989 30.2 30 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 8.96540389483775e-20 5.10310789694165e-18 0.915800770095249 0.815950920245399 30.2 30 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.10648358754881e-08 9.10130719700554e-08 0.915165165165165 0.815384615384615 30.2 30 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 9.46545102617121e-15 2.64104643338071e-13 0.914874958992606 0.815126050420168 30.2 30 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000262906683845372 0.000864009725431789 0.914525636747859 0.814814814814815 30.2 30 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000262906683845372 0.000864009725431789 0.914525636747859 0.814814814814815 30.2 30 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 5.05658451742087e-17 1.71321899244997e-15 0.913931788931789 0.814285714285714 30.2 30 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 3.39142225981687e-09 3.19602243425126e-08 0.913931788931789 0.814285714285714 30.2 30 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 3.94400040157894e-06 1.8162823855815e-05 0.913558907744954 0.813953488372093 30.2 30 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 3.94400040157894e-06 1.8162823855815e-05 0.913558907744954 0.813953488372093 30.2 30 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 8.78389171070396e-17 2.84079043280267e-15 0.912432216389051 0.81294964028777 30.2 30 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 4.7113744038621e-19 2.39438777739135e-17 0.911927552552553 0.8125 30.2 30 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 7.7266865616036e-05 0.000279772900182237 0.911927552552553 0.8125 30.2 30 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00566584334123101 0.0128383679531397 0.911927552552553 0.8125 30.2 30 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00566584334123101 0.0128383679531397 0.911927552552553 0.8125 30.2 30 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00566584334123101 0.0128383679531397 0.911927552552553 0.8125 30.2 30 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00566584334123101 0.0128383679531397 0.911927552552553 0.8125 30.2 30 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00566584334123101 0.0128383679531397 0.911927552552553 0.8125 30.2 30 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00566584334123101 0.0128383679531397 0.911927552552553 0.8125 30.2 30 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 5.89411690035711e-09 5.0832293025504e-08 0.910910910910911 0.811594202898551 30.2 30 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 5.89411690035711e-09 5.0832293025504e-08 0.910910910910911 0.811594202898551 30.2 30 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 8.16781445062554e-19 4.00786205628971e-17 0.910604000226642 0.811320754716981 30.2 30 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 2.29410491919577e-05 9.22178333337734e-05 0.910031653274896 0.810810810810811 30.2 30 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.09566848861031e-07 6.83831692672135e-07 0.909508646577612 0.810344827586207 30.2 30 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.3407416580374e-08 2.48893998920797e-07 0.908587158587159 0.80952380952381 30.2 30 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00159394517356219 0.00428768238559358 0.908587158587159 0.80952380952381 30.2 30 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00159394517356219 0.00428768238559358 0.908587158587159 0.80952380952381 30.2 30 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00159394517356219 0.00428768238559358 0.908587158587159 0.80952380952381 30.2 30 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.44411058329542e-18 1.12192560000948e-16 0.907906313957269 0.808917197452229 30.2 30 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.06577666284099e-06 1.02425093770827e-05 0.907450003194684 0.808510638297872 30.2 30 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 6.24687021433672e-07 3.35445143962308e-06 0.906531531531531 0.807692307692308 30.2 30 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000459313322322656 0.00144283191537558 0.906531531531531 0.807692307692308 30.2 30 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.000459313322322656 0.00144283191537558 0.906531531531531 0.807692307692308 30.2 30 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000459313322322656 0.00144283191537558 0.906531531531531 0.807692307692308 30.2 30 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000459313322322656 0.00144283191537558 0.906531531531531 0.807692307692308 30.2 30 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000459313322322656 0.00144283191537558 0.906531531531531 0.807692307692308 30.2 30 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 2.94903578484989e-10 3.95894143569942e-09 0.906011433119867 0.807228915662651 30.2 30 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.5156574174183e-25 2.94281206175661e-23 0.905950793843171 0.807174887892377 30.2 30 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.43833625566672e-16 7.54294019959508e-15 0.905914843414843 0.807142857142857 30.2 30 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 5.77471573335831e-08 3.80436133730041e-07 0.90513900997772 0.806451612903226 30.2 30 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000134467344912369 0.000464434543228886 0.90513900997772 0.806451612903226 30.2 30 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 5.39561664702321e-09 4.71040643479388e-08 0.904133299966633 0.805555555555556 30.2 30 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 5.39561664702321e-09 4.71040643479388e-08 0.904133299966633 0.805555555555556 30.2 30 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 3.98095459172958e-05 0.000153105361730573 0.904133299966633 0.805555555555556 30.2 30 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.65792903414279e-32 3.78223301558518e-30 0.904026893787986 0.805460750853242 30.2 30 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 1.18842146248772e-05 5.10913516954692e-05 0.903372885080202 0.804878048780488 30.2 30 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.56230189779181e-10 2.53021706434361e-09 0.903058230644438 0.804597701149425 30.2 30 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.56230189779181e-10 2.53021706434361e-09 0.903058230644438 0.804597701149425 30.2 30 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 9.94585605839435e-08 6.23478113264104e-07 0.901577807315512 0.80327868852459 30.2 30 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 9.94585605839435e-08 6.23478113264104e-07 0.901577807315512 0.80327868852459 30.2 30 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 9.94585605839435e-08 6.23478113264104e-07 0.901577807315512 0.80327868852459 30.2 30 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.29173050955206e-14 3.46817455677846e-13 0.901432928991984 0.803149606299213 30.2 30 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.2927554662931e-45 3.67918205707015e-43 0.90105951021444 0.802816901408451 30.2 30 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.68684298523609e-17 1.27960428487584e-15 0.900851509404141 0.802631578947368 30.2 30 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.05759294216468e-19 5.78828752577054e-18 0.900434332637722 0.80225988700565 30.2 30 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 7.15296264648866e-14 1.78573085016726e-12 0.899753058843968 0.801652892561983 30.2 30 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 7.15296264648866e-14 1.78573085016726e-12 0.899753058843968 0.801652892561983 30.2 30 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 4.14397243269207e-12 8.19010107183446e-11 0.897897897897898 0.8 30.2 30 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 4.59339614700332e-10 5.94218428835066e-09 0.897897897897898 0.8 30.2 30 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 4.59339614700332e-10 5.94218428835066e-09 0.897897897897898 0.8 30.2 30 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 4.59339614700332e-10 5.94218428835066e-09 0.897897897897898 0.8 30.2 30 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 5.20350837645584e-08 3.44399647427752e-07 0.897897897897898 0.8 30.2 30 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.70656455817624e-07 1.01608425367565e-06 0.897897897897898 0.8 30.2 30 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 5.61322035807382e-07 3.02561082179509e-06 0.897897897897898 0.8 30.2 30 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.61322035807382e-07 3.02561082179509e-06 0.897897897897898 0.8 30.2 30 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 5.61322035807382e-07 3.02561082179509e-06 0.897897897897898 0.8 30.2 30 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 5.61322035807382e-07 3.02561082179509e-06 0.897897897897898 0.8 30.2 30 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 5.61322035807382e-07 3.02561082179509e-06 0.897897897897898 0.8 30.2 30 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00277402312624266 0.00687706430077231 0.897897897897898 0.8 30.2 30 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00277402312624266 0.00687706430077231 0.897897897897898 0.8 30.2 30 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00277402312624266 0.00687706430077231 0.897897897897898 0.8 30.2 30 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00277402312624266 0.00687706430077231 0.897897897897898 0.8 30.2 30 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00277402312624266 0.00687706430077231 0.897897897897898 0.8 30.2 30 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00277402312624266 0.00687706430077231 0.897897897897898 0.8 30.2 30 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00992193972886903 0.0211361081350009 0.897897897897898 0.8 30.2 30 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00992193972886903 0.0211361081350009 0.897897897897898 0.8 30.2 30 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00992193972886903 0.0211361081350009 0.897897897897898 0.8 30.2 30 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00992193972886903 0.0211361081350009 0.897897897897898 0.8 30.2 30 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00992193972886903 0.0211361081350009 0.897897897897898 0.8 30.2 30 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0371386957508826 0.0652448938932172 0.897897897897898 0.8 30.2 30 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.34267835774625e-11 2.54750840409722e-10 0.897897897897898 0.8 30.2 30 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.34267835774625e-11 2.54750840409722e-10 0.897897897897898 0.8 30.2 30 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 6.86693772830994e-05 0.00025119929016414 0.897897897897898 0.8 30.2 30 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000796161704387019 0.00235049399448699 0.897897897897898 0.8 30.2 30 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000796161704387019 0.00235049399448699 0.897897897897898 0.8 30.2 30 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.29209217822107e-11 4.23590541507609e-10 0.895630478963812 0.797979797979798 30.2 30 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.05530248105305e-14 2.88787582795863e-13 0.894522341890763 0.796992481203007 30.2 30 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 8.89131925404256e-08 5.64836932968864e-07 0.894390484234234 0.796875 30.2 30 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.91685283034458e-07 1.6405856037867e-06 0.894093245788161 0.796610169491525 30.2 30 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.91685283034458e-07 1.6405856037867e-06 0.894093245788161 0.796610169491525 30.2 30 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 9.59739525611758e-07 5.03951787802779e-06 0.893740963185408 0.796296296296296 30.2 30 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.90319876510543e-11 7.03069853512029e-10 0.893316786173929 0.795918367346939 30.2 30 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.26577017723622e-10 2.14427495500851e-09 0.893070489844683 0.795698924731183 30.2 30 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.05110175674969e-05 4.56011524345978e-05 0.892796205296205 0.795454545454545 30.2 30 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000117702695583819 0.000409513290503115 0.891295707472178 0.794117647058823 30.2 30 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 1.51361544845925e-07 9.12658806422674e-07 0.890771724105057 0.793650793650794 30.2 30 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 1.63377923474949e-06 8.18615440510044e-06 0.889427163012069 0.792452830188679 30.2 30 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.16009172824043e-14 1.35977972764558e-12 0.889264264264264 0.792307692307692 30.2 30 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.40353667818106e-08 1.86897961368942e-07 0.888544794794795 0.791666666666667 30.2 30 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 5.39500252522146e-06 2.41417880295287e-05 0.888544794794795 0.791666666666667 30.2 30 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 5.39500252522146e-06 2.41417880295287e-05 0.888544794794795 0.791666666666667 30.2 30 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00136835454139797 0.00370889240458917 0.888544794794795 0.791666666666667 30.2 30 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00136835454139797 0.00370889240458917 0.888544794794795 0.791666666666667 30.2 30 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 7.84631103463056e-08 5.02941468571139e-07 0.887846802025906 0.791044776119403 30.2 30 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.81400447560711e-13 6.35607677585543e-12 0.887036229778165 0.790322580645161 30.2 30 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.81400447560711e-13 6.35607677585543e-12 0.887036229778165 0.790322580645161 30.2 30 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.81400447560711e-13 6.35607677585543e-12 0.887036229778165 0.790322580645161 30.2 30 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.56678465142993e-07 1.45519305138836e-06 0.887036229778165 0.790322580645161 30.2 30 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 9.46507661020745e-12 1.84504164607194e-10 0.88554150480756 0.788990825688073 30.2 30 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 4.06419529355319e-08 2.91549893973893e-07 0.88525144863173 0.788732394366197 30.2 30 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 4.74592078654942e-13 1.05522582488435e-11 0.885122927805855 0.788617886178862 30.2 30 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.76857283021707e-06 1.304529515695e-05 0.884947447447447 0.788461538461538 30.2 30 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.76857283021707e-06 1.304529515695e-05 0.884947447447447 0.788461538461538 30.2 30 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.99403465021265e-09 1.93027980085211e-08 0.884693517046458 0.788235294117647 30.2 30 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.99403465021265e-09 1.93027980085211e-08 0.884693517046458 0.788235294117647 30.2 30 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.47871289308573e-13 5.87868074476833e-12 0.883757773521553 0.78740157480315 30.2 30 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.10389695245875e-08 1.65405821179492e-07 0.882932932932933 0.786666666666667 30.2 30 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.10389695245875e-08 1.65405821179492e-07 0.882932932932933 0.786666666666667 30.2 30 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.10389695245875e-08 1.65405821179492e-07 0.882932932932933 0.786666666666667 30.2 30 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.10389695245875e-08 1.65405821179492e-07 0.882932932932933 0.786666666666667 30.2 30 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.10389695245875e-08 1.65405821179492e-07 0.882932932932933 0.786666666666667 30.2 30 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.10389695245875e-08 1.65405821179492e-07 0.882932932932933 0.786666666666667 30.2 30 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 6.74238936578949e-22 4.79721003375922e-20 0.88259282009282 0.786363636363636 30.2 30 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 3.02927789000064e-05 0.000117137566235623 0.881864006864007 0.785714285714286 30.2 30 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 3.02927789000064e-05 0.000117137566235623 0.881864006864007 0.785714285714286 30.2 30 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.4207965953196e-06 7.22069126835641e-06 0.881864006864007 0.785714285714286 30.2 30 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000679125708097014 0.00201752793866817 0.881864006864007 0.785714285714286 30.2 30 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000679125708097014 0.00201752793866817 0.881864006864007 0.785714285714286 30.2 30 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.01715013593038 0.0338953380957371 0.881864006864007 0.785714285714286 30.2 30 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.01715013593038 0.0338953380957371 0.881864006864007 0.785714285714286 30.2 30 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.01715013593038 0.0338953380957371 0.881864006864007 0.785714285714286 30.2 30 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.01715013593038 0.0338953380957371 0.881864006864007 0.785714285714286 30.2 30 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.01715013593038 0.0338953380957371 0.881864006864007 0.785714285714286 30.2 30 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.01715013593038 0.0338953380957371 0.881864006864007 0.785714285714286 30.2 30 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.43086353417275e-50 2.10170626970928e-47 0.881254353212528 0.785171102661597 30.2 30 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.48390072937828e-35 2.63948842238162e-33 0.87929172487996 0.783422459893048 30.2 30 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.5397823670618e-05 6.35104437196795e-05 0.878378378378378 0.782608695652174 30.2 30 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.5397823670618e-05 6.35104437196795e-05 0.878378378378378 0.782608695652174 30.2 30 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.82479564321552e-08 1.49234724154925e-07 0.877752752752753 0.782051282051282 30.2 30 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.32876735435352e-11 4.24850762210906e-10 0.877491127491128 0.781818181818182 30.2 30 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 2.38740219741078e-06 1.1645339946641e-05 0.877491127491128 0.781818181818182 30.2 30 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 6.63426876962289e-18 2.95017639349168e-16 0.87704507786475 0.781420765027322 30.2 30 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.84859105012761e-20 1.68897711013816e-18 0.876519376519377 0.780952380952381 30.2 30 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 9.41785203685114e-09 7.88329614614069e-08 0.875997949168681 0.780487804878049 30.2 30 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.4152843798112e-10 3.30475930045321e-09 0.87545045045045 0.78 30.2 30 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.22142329660537e-06 6.22969659881522e-06 0.875069985239477 0.779661016949153 30.2 30 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.92263943570727e-07 1.12127701516863e-06 0.874790231407878 0.779411764705882 30.2 30 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 4.86027260450743e-09 4.29575646969818e-08 0.874406383127313 0.779069767441861 30.2 30 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00813784180576502 0.0175990104705222 0.872956289622956 0.777777777777778 30.2 30 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00813784180576502 0.0175990104705222 0.872956289622956 0.777777777777778 30.2 30 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00813784180576502 0.0175990104705222 0.872956289622956 0.777777777777778 30.2 30 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0645816223113142 0.102338138695991 0.872956289622956 0.777777777777778 30.2 30 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.99291821673161e-06 1.83287826529325e-05 0.872956289622956 0.777777777777778 30.2 30 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00114673655699315 0.00315020486602559 0.872956289622956 0.777777777777778 30.2 30 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00114673655699315 0.00315020486602559 0.872956289622956 0.777777777777778 30.2 30 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00114673655699315 0.00315020486602559 0.872956289622956 0.777777777777778 30.2 30 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 5.07510780128686e-08 3.37470953328561e-07 0.87131539434171 0.776315789473684 30.2 30 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.03671487433354e-06 1.01337247069113e-05 0.870806150978565 0.775862068965517 30.2 30 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 9.57401894550973e-21 5.92340389541754e-19 0.870719374082603 0.775784753363229 30.2 30 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 4.1662023228605e-09 3.77611841110222e-08 0.870153861726895 0.775280898876405 30.2 30 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 8.52867449638565e-05 0.000306472318392848 0.869838588588589 0.775 30.2 30 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 8.52867449638565e-05 0.000306472318392848 0.869838588588589 0.775 30.2 30 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 8.52867449638565e-05 0.000306472318392848 0.869838588588589 0.775 30.2 30 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.64167576874052e-07 9.81556562570489e-07 0.869443387049021 0.774647887323944 30.2 30 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.03992679865501e-06 5.40078771710248e-06 0.868933449578611 0.774193548387097 30.2 30 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.000568296526077469 0.00171695532188586 0.868933449578611 0.774193548387097 30.2 30 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 6.6457842813979e-06 2.95529719763413e-05 0.868250325797496 0.773584905660377 30.2 30 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00392832962164311 0.00928573596610988 0.867287742287742 0.772727272727273 30.2 30 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.00392832962164311 0.00928573596610988 0.867287742287742 0.772727272727273 30.2 30 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 8.73412971532655e-15 2.48573331698194e-13 0.86664195841411 0.772151898734177 30.2 30 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 4.31961092735022e-08 2.92705064267589e-07 0.86664195841411 0.772151898734177 30.2 30 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.31961092735022e-08 2.92705064267589e-07 0.86664195841411 0.772151898734177 30.2 30 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.31961092735022e-08 2.92705064267589e-07 0.86664195841411 0.772151898734177 30.2 30 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 4.31961092735022e-08 2.92705064267589e-07 0.86664195841411 0.772151898734177 30.2 30 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 3.38063377896555e-06 1.57210518544705e-05 0.866392708497972 0.771929824561403 30.2 30 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.21739228296807e-08 1.73370836190306e-07 0.865443757010022 0.771084337349398 30.2 30 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 2.17290234365306e-05 8.75932021251645e-05 0.865162037037037 0.770833333333333 30.2 30 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 2.17290234365306e-05 8.75932021251645e-05 0.865162037037037 0.770833333333333 30.2 30 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.39144979694352e-07 8.46167974807959e-07 0.864530070611152 0.77027027027027 30.2 30 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.39144979694352e-07 8.46167974807959e-07 0.864530070611152 0.77027027027027 30.2 30 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.10054585724648e-05 4.74568713594466e-05 0.863363363363363 0.769230769230769 30.2 30 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00191898964460156 0.00492910156005058 0.863363363363363 0.769230769230769 30.2 30 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0292062872885048 0.0528088269524045 0.863363363363363 0.769230769230769 30.2 30 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.29106465670151e-07 1.3040740025945e-06 0.860997984285656 0.767123287671233 30.2 30 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.000945661128384322 0.00274068388124418 0.860485485485486 0.766666666666667 30.2 30 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 4.09100620939176e-10 5.44065592146213e-09 0.860135836771351 0.766355140186916 30.2 30 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 5.9979772559249e-08 3.93323577658117e-07 0.859099840581322 0.765432098765432 30.2 30 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.07232790384182e-08 2.31318656463858e-07 0.858284755343579 0.764705882352941 30.2 30 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.07232790384182e-08 2.31318656463858e-07 0.858284755343579 0.764705882352941 30.2 30 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.07232790384182e-08 2.31318656463858e-07 0.858284755343579 0.764705882352941 30.2 30 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.07232790384182e-08 2.31318656463858e-07 0.858284755343579 0.764705882352941 30.2 30 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.07232790384182e-08 2.31318656463858e-07 0.858284755343579 0.764705882352941 30.2 30 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0136849977004801 0.027661579158783 0.858284755343579 0.764705882352941 30.2 30 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0136849977004801 0.027661579158783 0.858284755343579 0.764705882352941 30.2 30 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0136849977004801 0.027661579158783 0.858284755343579 0.764705882352941 30.2 30 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.97260324771586e-16 6.23780982555482e-15 0.858284755343579 0.764705882352941 30.2 30 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.91932825376004e-07 1.12127701516863e-06 0.856547336810495 0.763157894736842 30.2 30 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.91932825376004e-07 1.12127701516863e-06 0.856547336810495 0.763157894736842 30.2 30 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 5.02078583048428e-08 3.35426208299489e-07 0.855140855140855 0.761904761904762 30.2 30 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 5.02078583048428e-08 3.35426208299489e-07 0.855140855140855 0.761904761904762 30.2 30 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00655027257482017 0.0144832534897512 0.855140855140855 0.761904761904762 30.2 30 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00655027257482017 0.0144832534897512 0.855140855140855 0.761904761904762 30.2 30 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00655027257482017 0.0144832534897512 0.855140855140855 0.761904761904762 30.2 30 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 5.61461732503908e-10 7.19783824642398e-09 0.854650522081715 0.761467889908257 30.2 30 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 2.57090062761685e-08 1.98825630059716e-07 0.854533510783511 0.761363636363636 30.2 30 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 5.89130512877373e-05 0.000217184642441581 0.853978978978979 0.760869565217391 30.2 30 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 2.97019068964935e-05 0.000115480364791558 0.853003003003003 0.76 30.2 30 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00318029852526599 0.00775355908224173 0.853003003003003 0.76 30.2 30 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00318029852526599 0.00775355908224173 0.853003003003003 0.76 30.2 30 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00318029852526599 0.00775355908224173 0.853003003003003 0.76 30.2 30 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.77830215276504e-09 1.74518894026528e-08 0.852571321321321 0.759615384615385 30.2 30 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.5994323318639e-07 9.60334265081149e-07 0.852434713194207 0.759493670886076 30.2 30 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 9.61305217227333e-05 0.000341984331028624 0.848014681348015 0.755555555555556 30.2 30 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 3.03589863378601e-15 9.1916675656968e-14 0.847879129129129 0.755434782608696 30.2 30 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.71864552070395e-12 7.4530036281151e-11 0.847665847665848 0.755244755244755 30.2 30 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 4.83839523291534e-05 0.000181663229985185 0.84750566893424 0.755102040816326 30.2 30 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.61762470802675e-06 8.13385144707443e-06 0.845845845845846 0.753623188405797 30.2 30 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.1446948669709e-07 1.23558736668e-06 0.845243391539688 0.753086419753086 30.2 30 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.1446948669709e-07 1.23558736668e-06 0.845243391539688 0.753086419753086 30.2 30 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.1446948669709e-07 1.23558736668e-06 0.845243391539688 0.753086419753086 30.2 30 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00062372421820475 0.00188042280191813 0.841779279279279 0.75 30.2 30 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.08779904402031e-12 2.34536066612258e-11 0.841779279279279 0.75 30.2 30 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 3.18423678593546e-09 3.02077929759078e-08 0.841779279279279 0.75 30.2 30 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 4.61497225639319e-08 3.11237228476185e-07 0.841779279279279 0.75 30.2 30 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 5.13244092130894e-06 2.31855981937226e-05 0.841779279279279 0.75 30.2 30 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000311127168286695 0.000992677041416968 0.841779279279279 0.75 30.2 30 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00125692179139778 0.0034198847211454 0.841779279279279 0.75 30.2 30 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.00125692179139778 0.0034198847211454 0.841779279279279 0.75 30.2 30 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00521558622454501 0.0119706116089154 0.841779279279279 0.75 30.2 30 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00521558622454501 0.0119706116089154 0.841779279279279 0.75 30.2 30 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0107914294324968 0.0227162782284659 0.841779279279279 0.75 30.2 30 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0107914294324968 0.0227162782284659 0.841779279279279 0.75 30.2 30 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0107914294324968 0.0227162782284659 0.841779279279279 0.75 30.2 30 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0107914294324968 0.0227162782284659 0.841779279279279 0.75 30.2 30 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0107914294324968 0.0227162782284659 0.841779279279279 0.75 30.2 30 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0107914294324968 0.0227162782284659 0.841779279279279 0.75 30.2 30 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0226902288917831 0.0432817636903585 0.841779279279279 0.75 30.2 30 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0226902288917831 0.0432817636903585 0.841779279279279 0.75 30.2 30 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0488926312733546 0.0813439165175012 0.841779279279279 0.75 30.2 30 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0488926312733546 0.0813439165175012 0.841779279279279 0.75 30.2 30 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0488926312733546 0.0813439165175012 0.841779279279279 0.75 30.2 30 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0488926312733546 0.0813439165175012 0.841779279279279 0.75 30.2 30 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 48%5605104 DISSOLUTION OF FIBRIN CLOT 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.109887584537704 0.15810923437528 0.841779279279279 0.75 30.2 30 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.14801009195511e-09 2.06528267625144e-08 0.836856593435541 0.745614035087719 30.2 30 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 6.35289149619743e-05 0.000233595984472582 0.836277453924513 0.745098039215686 30.2 30 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.000501474337991104 0.00155467970144083 0.834584584584585 0.743589743589744 30.2 30 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000501474337991104 0.00155467970144083 0.834584584584585 0.743589743589744 30.2 30 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.000501474337991104 0.00155467970144083 0.834584584584585 0.743589743589744 30.2 30 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.000501474337991104 0.00155467970144083 0.834584584584585 0.743589743589744 30.2 30 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00100636091887817 0.00283014147739849 0.833762333762334 0.742857142857143 30.2 30 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00100636091887817 0.00283014147739849 0.833762333762334 0.742857142857143 30.2 30 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00100636091887817 0.00283014147739849 0.833762333762334 0.742857142857143 30.2 30 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.67810329183562e-07 2.06060668672523e-06 0.8318759936407 0.741176470588235 30.2 30 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 7.23750209008055e-61 5.14948273709231e-58 0.830352411234764 0.739819004524887 30.2 30 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.7609084192083e-06 1.304529515695e-05 0.830248056275454 0.73972602739726 30.2 30 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000201580021288556 0.000681350048203361 0.82957957957958 0.739130434782609 30.2 30 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00845646990677519 0.0182603287971792 0.82957957957958 0.739130434782609 30.2 30 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 1.23912626499994e-07 7.66642032649964e-07 0.827011221748064 0.736842105263158 30.2 30 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.23912626499994e-07 7.66642032649964e-07 0.827011221748064 0.736842105263158 30.2 30 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0175443496940497 0.0346263656236237 0.827011221748064 0.736842105263158 30.2 30 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.37275989251875e-06 1.99437093815839e-05 0.826190774107441 0.736111111111111 30.2 30 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00160995504646791 0.00431443697010138 0.82527380321498 0.735294117647059 30.2 30 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00160995504646791 0.00431443697010138 0.82527380321498 0.735294117647059 30.2 30 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 1.68425141554208e-05 6.92620827135262e-05 0.824242210960961 0.734375 30.2 30 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.53585934931873e-17 6.24436529737301e-16 0.823963844797178 0.734126984126984 30.2 30 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.53585934931873e-17 6.24436529737301e-16 0.823963844797178 0.734126984126984 30.2 30 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.53585934931873e-17 6.24436529737301e-16 0.823963844797178 0.734126984126984 30.2 30 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.00324940677510414 0.00783712854402235 0.823073073073073 0.733333333333333 30.2 30 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00324940677510414 0.00783712854402235 0.823073073073073 0.733333333333333 30.2 30 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00324940677510414 0.00783712854402235 0.823073073073073 0.733333333333333 30.2 30 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.037027675484535 0.0652448938932172 0.823073073073073 0.733333333333333 30.2 30 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.037027675484535 0.0652448938932172 0.823073073073073 0.733333333333333 30.2 30 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.037027675484535 0.0652448938932172 0.823073073073073 0.733333333333333 30.2 30 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000637050810728163 0.00190446072198776 0.821248077345638 0.731707317073171 30.2 30 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.35115541964652e-05 5.72230405403869e-05 0.820839496212631 0.73134328358209 30.2 30 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.40027740138001e-34 2.21399415795973e-32 0.8197101595978 0.730337078651685 30.2 30 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.000254594869833967 0.000840576565600312 0.818396521521522 0.729166666666667 30.2 30 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 5.76653064425303e-11 1.02572163834651e-09 0.818245665019859 0.729032258064516 30.2 30 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 5.20942388625837e-05 0.000195079215530149 0.818000203593424 0.728813559322034 30.2 30 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.08168942870939e-05 4.67855336490415e-05 0.817728442728443 0.728571428571429 30.2 30 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 4.22060984951665e-08 2.91549893973893e-07 0.816270816270816 0.727272727272727 30.2 30 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.000102509568531642 0.000363768369128494 0.816270816270816 0.727272727272727 30.2 30 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 9.03036616211261e-09 7.60367517673742e-08 0.816270816270816 0.727272727272727 30.2 30 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 9.33349893867676e-07 4.91909962582853e-06 0.816270816270816 0.727272727272727 30.2 30 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00255237566529513 0.00639442002062494 0.816270816270816 0.727272727272727 30.2 30 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0802335472041678 0.126018032750034 0.816270816270816 0.727272727272727 30.2 30 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0802335472041678 0.126018032750034 0.816270816270816 0.727272727272727 30.2 30 2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0802335472041678 0.126018032750034 0.816270816270816 0.727272727272727 30.2 30 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0802335472041678 0.126018032750034 0.816270816270816 0.727272727272727 30.2 30 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0802335472041678 0.126018032750034 0.816270816270816 0.727272727272727 30.2 30 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0802335472041678 0.126018032750034 0.816270816270816 0.727272727272727 30.2 30 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0802335472041678 0.126018032750034 0.816270816270816 0.727272727272727 30.2 30 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.95970361875037e-48 6.97164562370443e-46 0.814833719763297 0.725992317541613 30.2 30 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 7.25539471847939e-09 6.18229142778214e-08 0.814625108979948 0.725806451612903 30.2 30 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.68896294459547e-05 6.92620827135262e-05 0.813313313313313 0.72463768115942 30.2 30 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.45292918332371e-06 7.35771611341507e-06 0.812752407579994 0.724137931034483 30.2 30 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00514720558613292 0.0118621534765265 0.812752407579994 0.724137931034483 30.2 30 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00514720558613292 0.0118621534765265 0.812752407579994 0.724137931034483 30.2 30 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.00404584649052e-09 1.17271938905277e-08 0.811928950226823 0.723404255319149 30.2 30 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00200121634062906 0.00512181808042293 0.810602268935602 0.722222222222222 30.2 30 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00200121634062906 0.00512181808042293 0.810602268935602 0.722222222222222 30.2 30 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0281076030267393 0.0514101788008355 0.810602268935602 0.722222222222222 30.2 30 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0281076030267393 0.0514101788008355 0.810602268935602 0.722222222222222 30.2 30 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0281076030267393 0.0514101788008355 0.810602268935602 0.722222222222222 30.2 30 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 2.25251919489691e-06 1.10667143996775e-05 0.809152175431245 0.720930232558139 30.2 30 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 8.13158053590512e-08 5.18889645856188e-07 0.808917025133241 0.720720720720721 30.2 30 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0104491831655483 0.0222259905001124 0.808108108108108 0.72 30.2 30 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.42005173867901e-13 5.83683665108514e-12 0.807039182039182 0.719047619047619 30.2 30 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.00024839619017692 0.000823934215901533 0.804719814153776 0.716981132075472 30.2 30 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.28944058227401e-08 2.46361786767153e-07 0.802998120071291 0.715447154471545 30.2 30 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.47580106594811e-88 3.52306491684416e-85 0.802833175331561 0.715300193673338 30.2 30 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000487766904506846 0.00152883767646088 0.801694551694552 0.714285714285714 30.2 30 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00122629144368731 0.00334935263794058 0.801694551694552 0.714285714285714 30.2 30 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00122629144368731 0.00334935263794058 0.801694551694552 0.714285714285714 30.2 30 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00806507187298565 0.0175215225576467 0.801694551694552 0.714285714285714 30.2 30 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00806507187298565 0.0175215225576467 0.801694551694552 0.714285714285714 30.2 30 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00806507187298565 0.0175215225576467 0.801694551694552 0.714285714285714 30.2 30 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00806507187298565 0.0175215225576467 0.801694551694552 0.714285714285714 30.2 30 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0593466656838167 0.0958573272055291 0.801694551694552 0.714285714285714 30.2 30 2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.182010230582679 0.246432500589108 0.801694551694552 0.714285714285714 30.2 30 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.56475396865688e-10 3.4758522832369e-09 0.800716875411997 0.713414634146341 30.2 30 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 1.73873160090201e-06 8.68145637924059e-06 0.79998881860584 0.712765957446808 30.2 30 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 8.17564021981659e-15 2.3742726597549e-13 0.796664311370194 0.709803921568627 30.2 30 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00622875045642946 0.0140914338624787 0.796522328780393 0.709677419354839 30.2 30 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00188839774689582 0.00485929474472469 0.793873141434117 0.707317073170732 30.2 30 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00188839774689582 0.00485929474472469 0.793873141434117 0.707317073170732 30.2 30 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00188839774689582 0.00485929474472469 0.793873141434117 0.707317073170732 30.2 30 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00188839774689582 0.00485929474472469 0.793873141434117 0.707317073170732 30.2 30 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00188839774689582 0.00485929474472469 0.793873141434117 0.707317073170732 30.2 30 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00481418515048045 0.0112489088163115 0.792262851086381 0.705882352941177 30.2 30 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00481418515048045 0.0112489088163115 0.792262851086381 0.705882352941177 30.2 30 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.0443027837509103 0.0768815381433479 0.792262851086381 0.705882352941177 30.2 30 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0443027837509103 0.0768815381433479 0.792262851086381 0.705882352941177 30.2 30 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0443027837509103 0.0768815381433479 0.792262851086381 0.705882352941177 30.2 30 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0443027837509103 0.0768815381433479 0.792262851086381 0.705882352941177 30.2 30 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0443027837509103 0.0768815381433479 0.792262851086381 0.705882352941177 30.2 30 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.18432602580349e-06 1.49055787326262e-05 0.791567883673147 0.705263157894737 30.2 30 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.18432602580349e-06 1.49055787326262e-05 0.791567883673147 0.705263157894737 30.2 30 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.39919724889653e-07 8.47258589438198e-07 0.791180524787082 0.704918032786885 30.2 30 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 6.13912626550746e-30 6.71998205832085e-28 0.790181600164087 0.704028021015762 30.2 30 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000458145892027371 0.00144283191537558 0.789817595373151 0.703703703703704 30.2 30 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0124901085898736 0.0255365294876295 0.789817595373151 0.703703703703704 30.2 30 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0124901085898736 0.0255365294876295 0.789817595373151 0.703703703703704 30.2 30 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0124901085898736 0.0255365294876295 0.789817595373151 0.703703703703704 30.2 30 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 5.87286710659656e-11 1.03173949292431e-09 0.789168074324324 0.703125 30.2 30 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.7694891145071e-17 6.80535948633407e-16 0.788414948691022 0.702453987730061 30.2 30 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.56312970962368e-06 7.88770771912944e-06 0.787819069069069 0.701923076923077 30.2 30 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.128615117618988 0.183939007408864 0.785660660660661 0.7 30.2 30 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.128615117618988 0.183939007408864 0.785660660660661 0.7 30.2 30 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.128615117618988 0.183939007408864 0.785660660660661 0.7 30.2 30 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.128615117618988 0.183939007408864 0.785660660660661 0.7 30.2 30 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.128615117618988 0.183939007408864 0.785660660660661 0.7 30.2 30 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 4.63508317405227e-25 3.6642907537091e-23 0.784526951193618 0.698989898989899 30.2 30 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.56471610444299e-10 2.53021706434361e-09 0.783322384884885 0.697916666666667 30.2 30 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00735501868656048 0.0161266434375587 0.782259532259532 0.696969696969697 30.2 30 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.04418061166243e-08 8.65666489011459e-08 0.78204010462075 0.696774193548387 30.2 30 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.14599010169535e-06 5.92997787168177e-06 0.781652187902188 0.696428571428571 30.2 30 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0251664645486648 0.0462088761970968 0.780780780780781 0.695652173913043 30.2 30 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0251664645486648 0.0462088761970968 0.780780780780781 0.695652173913043 30.2 30 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00104344541264776 0.00292864461971944 0.777027027027027 0.692307692307692 30.2 30 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00436111317764991 0.0102746093572778 0.777027027027027 0.692307692307692 30.2 30 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0191011800849827 0.0373878669338795 0.777027027027027 0.692307692307692 30.2 30 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0191011800849827 0.0373878669338795 0.777027027027027 0.692307692307692 30.2 30 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0191011800849827 0.0373878669338795 0.777027027027027 0.692307692307692 30.2 30 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0931869052392669 0.142127509277038 0.777027027027027 0.692307692307692 30.2 30 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0931869052392669 0.142127509277038 0.777027027027027 0.692307692307692 30.2 30 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0931869052392669 0.142127509277038 0.777027027027027 0.692307692307692 30.2 30 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000810732594509601 0.00238855586332746 0.775457275457275 0.690909090909091 30.2 30 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.76753832418784e-30 6.87871931094236e-28 0.775012960082945 0.690513219284603 30.2 30 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000630303501429557 0.00188825659480897 0.774049911980946 0.689655172413793 30.2 30 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000630303501429557 0.00188825659480897 0.774049911980946 0.689655172413793 30.2 30 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000630303501429557 0.00188825659480897 0.774049911980946 0.689655172413793 30.2 30 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0145492191771029 0.0292422865664089 0.774049911980946 0.689655172413793 30.2 30 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0145492191771029 0.0292422865664089 0.774049911980946 0.689655172413793 30.2 30 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0145492191771029 0.0292422865664089 0.774049911980946 0.689655172413793 30.2 30 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.38657898014106e-13 3.40189980817368e-12 0.773910191780228 0.689530685920578 30.2 30 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000490308724709532 0.00153342706650915 0.77278097769901 0.688524590163934 30.2 30 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0111150129827481 0.0230969404452217 0.771631006006006 0.6875 30.2 30 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.67238233804887e-07 2.57705428955176e-06 0.77109552300392 0.687022900763359 30.2 30 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.67238233804887e-07 2.57705428955176e-06 0.77109552300392 0.687022900763359 30.2 30 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000231508439441966 0.000769711470387659 0.76962676962677 0.685714285714286 30.2 30 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00851290104510931 0.0183543305866524 0.76962676962677 0.685714285714286 30.2 30 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0509946519142335 0.0840850401783943 0.767938991623202 0.684210526315789 30.2 30 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00502486094509853 0.0117027448852295 0.766498205522596 0.682926829268293 30.2 30 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 1.94627681102678e-05 7.95848247727331e-05 0.763213213213213 0.68 30.2 30 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00230641966291817 0.0058817834772985 0.763213213213213 0.68 30.2 30 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0218318527699702 0.0419254068713463 0.761609824109824 0.678571428571429 30.2 30 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0166033727582848 0.0331368856031407 0.760316768381284 0.67741935483871 30.2 30 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0126676706256369 0.0258088640242806 0.759251898957781 0.676470588235294 30.2 30 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0126676706256369 0.0258088640242806 0.759251898957781 0.676470588235294 30.2 30 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00969115511265066 0.0208001715313754 0.758359711062414 0.675675675675676 30.2 30 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00969115511265066 0.0208001715313754 0.758359711062414 0.675675675675676 30.2 30 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.96739943139627e-18 9.33203130292299e-17 0.757475524852206 0.674887892376682 30.2 30 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00439493229198628 0.0103371713247876 0.756381381381381 0.673913043478261 30.2 30 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00202157556313621 0.00516463559487043 0.755050505050505 0.672727272727273 30.2 30 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 6.56621933986824e-39 1.55728835343875e-36 0.754989223457692 0.672672672672673 30.2 30 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.00121160806145608 0.00332200052302889 0.754381430610939 0.672131147540984 30.2 30 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.000266016224496935 0.000872214487233037 0.752983996654883 0.670886075949367 30.2 30 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000161275210862785 0.000546415773947007 0.752649708532061 0.670588235294118 30.2 30 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000161275210862785 0.000546415773947007 0.752649708532061 0.670588235294118 30.2 30 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 5.06276648716239e-06 2.29436837937327e-05 0.75119410749332 0.669291338582677 30.2 30 2 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.200499508990482 0.268401506390834 0.748248248248248 0.666666666666667 30.2 30 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.200499508990482 0.268401506390834 0.748248248248248 0.666666666666667 30.2 30 2 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.200499508990482 0.268401506390834 0.748248248248248 0.666666666666667 30.2 30 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.200499508990482 0.268401506390834 0.748248248248248 0.666666666666667 30.2 30 2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.200499508990482 0.268401506390834 0.748248248248248 0.666666666666667 30.2 30 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.200499508990482 0.268401506390834 0.748248248248248 0.666666666666667 30.2 30 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.200499508990482 0.268401506390834 0.748248248248248 0.666666666666667 30.2 30 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.200499508990482 0.268401506390834 0.748248248248248 0.666666666666667 30.2 30 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00493501140148371 0.0115123298759202 0.748248248248248 0.666666666666667 30.2 30 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0244968519075755 0.0450957571338679 0.748248248248248 0.666666666666667 30.2 30 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0323233230752009 0.058222897134191 0.748248248248248 0.666666666666667 30.2 30 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0323233230752009 0.058222897134191 0.748248248248248 0.666666666666667 30.2 30 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0323233230752009 0.058222897134191 0.748248248248248 0.666666666666667 30.2 30 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.10398464608238 0.152805182236292 0.748248248248248 0.666666666666667 30.2 30 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.142915379065794 0.203165418991633 0.748248248248248 0.666666666666667 30.2 30 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.142915379065794 0.203165418991633 0.748248248248248 0.666666666666667 30.2 30 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.142915379065794 0.203165418991633 0.748248248248248 0.666666666666667 30.2 30 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.142915379065794 0.203165418991633 0.748248248248248 0.666666666666667 30.2 30 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00105472098885518 0.00295446450224592 0.748248248248248 0.666666666666667 30.2 30 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0186350015751232 0.0366265293389507 0.748248248248248 0.666666666666667 30.2 30 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0186350015751232 0.0366265293389507 0.748248248248248 0.666666666666667 30.2 30 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0571148477596431 0.0938503791708685 0.748248248248248 0.666666666666667 30.2 30 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 4.5546644431433e-05 0.000174697776350213 0.744751761106901 0.663551401869159 30.2 30 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.00092953791857e-06 5.21729938629349e-06 0.743482335839024 0.662420382165605 30.2 30 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0120722226990848 0.0247889940848452 0.739123269611075 0.658536585365854 30.2 30 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.67203432631775e-17 9.74949960602605e-16 0.739123269611074 0.658536585365854 30.2 30 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000785710314511516 0.00232930370322893 0.738402876560771 0.657894736842105 30.2 30 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0157622970391006 0.031546763272349 0.738402876560771 0.657894736842105 30.2 30 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00467139446238071 0.0109512262272945 0.734643734643735 0.654545454545455 30.2 30 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00067390370673792 0.00201040875196658 0.734391799206614 0.654320987654321 30.2 30 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0471718385106368 0.0801977612910826 0.733858858858859 0.653846153846154 30.2 30 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0471718385106368 0.0801977612910826 0.733858858858859 0.653846153846154 30.2 30 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.062696721159975 0.101153553526808 0.731981981981982 0.652173913043478 30.2 30 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0132604138079414 0.0269180725373761 0.730847126195963 0.651162790697674 30.2 30 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0838539872849883 0.12973211131083 0.729542042042042 0.65 30.2 30 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00662027306036742 0.0145380379088007 0.727463574685797 0.648148148148148 30.2 30 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.011118344486983 0.0230969404452217 0.724865490490491 0.645833333333333 30.2 30 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0388486321790132 0.0681647393227321 0.724111207982176 0.645161290322581 30.2 30 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0144393624185878 0.0291449825839014 0.723306639973307 0.644444444444444 30.2 30 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00282483723375218 0.00699085805848583 0.721525096525097 0.642857142857143 30.2 30 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.154099336439077 0.212483871853495 0.721525096525096 0.642857142857143 30.2 30 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.154099336439077 0.212483871853495 0.721525096525096 0.642857142857143 30.2 30 2 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.154099336439077 0.212483871853495 0.721525096525096 0.642857142857143 30.2 30 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.154099336439077 0.212483871853495 0.721525096525096 0.642857142857143 30.2 30 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.154099336439077 0.212483871853495 0.721525096525096 0.642857142857143 30.2 30 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0093026115417135 0.0200266508681669 0.720012465295484 0.641509433962264 30.2 30 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 6.21217487748448e-06 2.77113631682145e-05 0.71779628465675 0.63953488372093 30.2 30 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0418619111503853 0.0731812033992608 0.714236964236964 0.636363636363636 30.2 30 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0418619111503853 0.0731812033992608 0.714236964236964 0.636363636363636 30.2 30 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0418619111503853 0.0731812033992608 0.714236964236964 0.636363636363636 30.2 30 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0901800143545796 0.137985118738244 0.714236964236964 0.636363636363636 30.2 30 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.213282865844923 0.282589867874604 0.714236964236964 0.636363636363636 30.2 30 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00141240223345295 0.00382100452129951 0.710835835835836 0.633333333333333 30.2 30 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0549659556044191 0.0905284199364449 0.710835835835836 0.633333333333333 30.2 30 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0167525205107059 0.0333877264520091 0.710072317215174 0.63265306122449 30.2 30 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0342720523648603 0.0616550322568852 0.70886676149834 0.631578947368421 30.2 30 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.120747705116427 0.173559580182501 0.70886676149834 0.631578947368421 30.2 30 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 1.76440815546755e-07 1.04395883393129e-06 0.708635105693929 0.631372549019608 30.2 30 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000267784741142193 0.000875994681943313 0.70838256289076 0.631147540983607 30.2 30 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0230816983154673 0.0433509186153855 0.701482732732733 0.625 30.2 30 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0957828917524851 0.1457743903356 0.701482732732733 0.625 30.2 30 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0957828917524851 0.1457743903356 0.701482732732733 0.625 30.2 30 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.163008959572032 0.223469893517342 0.701482732732733 0.625 30.2 30 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.163008959572032 0.223469893517342 0.701482732732733 0.625 30.2 30 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.163008959572032 0.223469893517342 0.701482732732733 0.625 30.2 30 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.163008959572032 0.223469893517342 0.701482732732733 0.625 30.2 30 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.163008959572032 0.223469893517342 0.701482732732733 0.625 30.2 30 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.163008959572032 0.223469893517342 0.701482732732733 0.625 30.2 30 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.302214640657639 0.374935861949277 0.701482732732733 0.625 30.2 30 2 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%REACT_208465.1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 0.302214640657639 0.374935861949277 0.701482732732733 0.625 30.2 30 2 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.302214640657639 0.374935861949277 0.701482732732733 0.625 30.2 30 2 EARLY STAGE PANCREATIC PRECURSOR CELLS%REACTOME%REACT_13403.1 EARLY STAGE PANCREATIC PRECURSOR CELLS 0.302214640657639 0.374935861949277 0.701482732732733 0.625 30.2 30 2 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.302214640657639 0.374935861949277 0.701482732732733 0.625 30.2 30 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.302214640657639 0.374935861949277 0.701482732732733 0.625 30.2 30 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.00787900617040345 0.0172224666366883 0.699449449449449 0.623188405797101 30.2 30 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.047401656062145 0.0804923109503966 0.697690934177421 0.621621621621622 30.2 30 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.222480937188238 0.286248077413076 0.690690690690691 0.615384615384615 30.2 30 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.222480937188238 0.286248077413076 0.690690690690691 0.615384615384615 30.2 30 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 3.59548361922584e-06 1.66657107171283e-05 0.689650493867361 0.614457831325301 30.2 30 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.170208070920891 0.233114614937852 0.685894227560894 0.611111111111111 30.2 30 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.4521255931506e-05 6.04203134226114e-05 0.684020930802047 0.609442060085837 30.2 30 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 6.60752968978614e-05 0.000242332854344476 0.683678602460328 0.609137055837564 30.2 30 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0424834143847516 0.0741765627846644 0.683183183183183 0.608695652173913 30.2 30 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.00454991907636011 0.0106840509004298 0.682680102783195 0.608247422680412 30.2 30 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0675337150646481 0.106897081798659 0.67933064643591 0.605263157894737 30.2 30 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0106037734072019 0.022521148594699 0.678966003040077 0.604938271604938 30.2 30 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00753264556237663 0.0164906994388645 0.675837127450031 0.602150537634409 30.2 30 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.056702458583564 0.0932804607681058 0.673423423423423 0.6 30.2 30 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.109140089406631 0.15810923437528 0.673423423423423 0.6 30.2 30 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.109140089406631 0.15810923437528 0.673423423423423 0.6 30.2 30 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.229271371974123 0.294718303811361 0.673423423423423 0.6 30.2 30 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.308326096047724 0.381520030152967 0.673423423423423 0.6 30.2 30 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.308326096047724 0.381520030152967 0.673423423423423 0.6 30.2 30 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.308326096047724 0.381520030152967 0.673423423423423 0.6 30.2 30 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0159303097055697 0.0318382453806541 0.663220038220038 0.590909090909091 30.2 30 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.180930196854589 0.246432500589108 0.663220038220038 0.590909090909091 30.2 30 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00081417258531503 0.00239373468781671 0.661289668046425 0.589189189189189 30.2 30 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0118518677462494 0.0243716875764636 0.658314564564564 0.586538461538462 30.2 30 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.184940280590702 0.250161615285712 0.654717217217217 0.583333333333333 30.2 30 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.311797347335702 0.384811470302432 0.654717217217217 0.583333333333333 30.2 30 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.311797347335702 0.384811470302432 0.654717217217217 0.583333333333333 30.2 30 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.311797347335702 0.384811470302432 0.654717217217217 0.583333333333333 30.2 30 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0975360134703528 0.148283917914863 0.652542076960682 0.581395348837209 30.2 30 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.148816296392459 0.211342903958551 0.651700087183958 0.580645161290323 30.2 30 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0042345280015759 0.00999292428895939 0.648326898326898 0.577639751552795 30.2 30 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00538388566551875 0.0123369876039182 0.644324880435991 0.574074074074074 30.2 30 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00548566267192585 0.0125499967558689 0.64331099392075 0.573170731707317 30.2 30 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.313656404853786 0.38643555333934 0.641355641355641 0.571428571428571 30.2 30 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.195285091553875 0.263653401595033 0.631334459459459 0.5625 30.2 30 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.314465902205382 0.386763162349403 0.631334459459459 0.5625 30.2 30 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.244957142339614 0.314597485152771 0.628528528528528 0.56 30.2 30 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0156483208984528 0.0313627614626737 0.626600526907275 0.558282208588957 30.2 30 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.429358555241584 0.523096938449293 0.62354020687354 0.555555555555556 30.2 30 2 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.429358555241584 0.523096938449293 0.62354020687354 0.555555555555556 30.2 30 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.429358555241584 0.523096938449293 0.62354020687354 0.555555555555556 30.2 30 2 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.429358555241584 0.523096938449293 0.62354020687354 0.555555555555556 30.2 30 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0222413567713058 0.0426542462069651 0.622735638864671 0.554838709677419 30.2 30 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0226144730394233 0.0432532192676066 0.62118722496081 0.553459119496855 30.2 30 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0226144730394233 0.0432532192676066 0.62118722496081 0.553459119496855 30.2 30 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.314150041949015 0.386708918419938 0.617304804804805 0.55 30.2 30 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.422377972291086 0.516360699802591 0.612203112203112 0.545454545454545 30.2 30 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.422377972291086 0.516360699802591 0.612203112203112 0.545454545454545 30.2 30 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.422377972291086 0.516360699802591 0.612203112203112 0.545454545454545 30.2 30 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.312331903738164 0.385137174193594 0.607951701701702 0.541666666666667 30.2 30 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.247658195440309 0.317779632201587 0.606687768849931 0.540540540540541 30.2 30 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.415999825841077 0.509877478184196 0.604354354354354 0.538461538461538 30.2 30 2 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.415999825841077 0.509877478184196 0.604354354354354 0.538461538461538 30.2 30 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.410096442430544 0.503509264519986 0.598598598598599 0.533333333333333 30.2 30 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.399386800497313 0.490783607174159 0.590722301248617 0.526315789473684 30.2 30 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.133777584038528 0.190938317037939 0.585237022737023 0.521428571428571 30.2 30 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.133366780839153 0.190543101540277 0.58489827856025 0.52112676056338 30.2 30 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.153785682478234 0.212483871853495 0.581667433857215 0.518248175182482 30.2 30 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.175354630089873 0.239932344824893 0.577691662250486 0.514705882352941 30.2 30 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.197889351475167 0.266916158435225 0.573474934788803 0.510948905109489 30.2 30 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.193865109070695 0.261984852998669 0.567220446252704 0.505376344086022 30.2 30 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.282153079755573 0.353747870037164 0.5668547335214 0.505050505050505 30.2 30 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.505726982655707 0.585556953880448 0.561186186186186 0.5 30.2 30 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.532958597246471 0.615584483670234 0.561186186186186 0.5 30.2 30 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.532958597246471 0.615584483670234 0.561186186186186 0.5 30.2 30 2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.550391014435444 0.632127855965809 0.561186186186186 0.5 30.2 30 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.550391014435444 0.632127855965809 0.561186186186186 0.5 30.2 30 2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.550391014435444 0.632127855965809 0.561186186186186 0.5 30.2 30 2 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.550391014435444 0.632127855965809 0.561186186186186 0.5 30.2 30 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.550391014435444 0.632127855965809 0.561186186186186 0.5 30.2 30 2 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.550391014435444 0.632127855965809 0.561186186186186 0.5 30.2 30 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0883702069141439 0.13536146871779 0.545308723357504 0.485853658536585 30.2 30 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.54287490616209 0.626529595676119 0.538738738738739 0.48 30.2 30 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.566581980726666 0.64967458386305 0.534463034463034 0.476190476190476 30.2 30 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.523694129394823 0.605867273275474 0.533586865554079 0.475409836065574 30.2 30 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.565623609259268 0.649098706432208 0.52682784825642 0.469387755102041 30.2 30 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.588782008291573 0.671881954930961 0.521666032229412 0.464788732394366 30.2 30 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.601866074071498 0.681348785524059 0.521101458601459 0.464285714285714 30.2 30 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.633208972736808 0.716261024009919 0.518018018018018 0.461538461538462 30.2 30 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.641356342639997 0.721109152390214 0.51016926016926 0.454545454545455 30.2 30 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.657068549555743 0.73449218068957 0.51016926016926 0.454545454545455 30.2 30 2 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.657068549555743 0.73449218068957 0.51016926016926 0.454545454545455 30.2 30 2 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.657068549555743 0.73449218068957 0.51016926016926 0.454545454545455 30.2 30 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.653330054352778 0.73203832074331 0.506877845587523 0.451612903225806 30.2 30 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.676463993368828 0.75557948395906 0.498832165498832 0.444444444444444 30.2 30 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.679754748267167 0.758659613164061 0.498832165498832 0.444444444444444 30.2 30 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.698116127744764 0.774898010749453 0.495164281928988 0.441176470588235 30.2 30 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.69444128753222 0.77142072768021 0.493843843843844 0.44 30.2 30 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.928631536370881 0.97164902665865 0.488868378687966 0.435567010309278 30.2 30 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.74914081305212 0.811284152947615 0.481016731016731 0.428571428571429 30.2 30 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.719358267168139 0.782483886886791 0.481016731016731 0.428571428571429 30.2 30 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.719358267168139 0.782483886886791 0.481016731016731 0.428571428571429 30.2 30 2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.719358267168139 0.782483886886791 0.481016731016731 0.428571428571429 30.2 30 2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.719358267168139 0.782483886886791 0.481016731016731 0.428571428571429 30.2 30 2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.719358267168139 0.782483886886791 0.481016731016731 0.428571428571429 30.2 30 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.958880111484412 0.996702993895046 0.472999785499785 0.421428571428571 30.2 30 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.746407637473761 0.808939884329903 0.472577840998894 0.421052631578947 30.2 30 2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.745718515490938 0.808809030139942 0.467655155155155 0.416666666666667 30.2 30 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.786483124845556 0.847852641405474 0.459152334152334 0.409090909090909 30.2 30 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.786483124845556 0.847852641405474 0.459152334152334 0.409090909090909 30.2 30 2 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.790224311495925 0.85124087453346 0.448948948948949 0.4 30.2 30 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.935986386964769 0.977906482122516 0.440424601817007 0.392405063291139 30.2 30 2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.835451607887022 0.897921176754707 0.439189189189189 0.391304347826087 30.2 30 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.965608921820801 1 0.436478144811478 0.388888888888889 30.2 30 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.868581531478326 0.922381730816162 0.434466724789305 0.387096774193548 30.2 30 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.868581531478326 0.922381730816162 0.434466724789305 0.387096774193548 30.2 30 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.913518365119136 0.965477768721636 0.429844738355377 0.382978723404255 30.2 30 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.993802848946284 1 0.427266755391755 0.380681818181818 30.2 30 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.934917570344623 0.977507496399998 0.423536744291461 0.377358490566038 30.2 30 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.912697508349237 0.965477768721636 0.416881166881167 0.371428571428571 30.2 30 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999450909614151 1 0.408605610218513 0.36405529953917 30.2 30 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.869747375570117 0.922931033136672 0.400847275847276 0.357142857142857 30.2 30 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.989949168551283 1 0.399065732399066 0.355555555555556 30.2 30 2 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.922055015947086 0.965477768721636 0.374124124124124 0.333333333333333 30.2 30 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.982553906740586 1 0.35443338074917 0.315789473684211 30.2 30 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.991372899303928 1 0.350741366366366 0.3125 30.2 30 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.962779895507643 0.999296711383936 0.336711711711712 0.3 30.2 30 2 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.962779895507643 0.999296711383936 0.336711711711712 0.3 30.2 30 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.987348134998925 1 0.325850043591979 0.290322580645161 30.2 30 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.31852381348603 0.283795130142737 30.2 30 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.998614740573305 1 0.303975850850851 0.270833333333333 30.2 30 2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.995622879017485 1 0.28964448319287 0.258064516129032 30.2 30 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.276026478558124 0.245931283905967 30.2 30 2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.995209120249426 1 0.269369369369369 0.24 30.2 30 2 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.999477142911202 1 0.267231517231517 0.238095238095238 30.2 30 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.998017588970793 1 0.261886886886887 0.233333333333333 30.2 30 2 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.996954965451615 1 0.243993993993994 0.217391304347826 30.2 30 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.998738962622828 1 0.240508365508365 0.214285714285714 30.2 30 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999937114842606 1 0.238802632419654 0.212765957446809 30.2 30 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0307747263392425 0.0274193548387097 30.2 30 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000277483034886373 0.0010336606247207 1.48381900717528 1 30.4 30 4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.000277483034886373 0.0010336606247207 1.48381900717528 1 30.4 30 4 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00171301582794472 0.00504683545168807 1.48381900717528 1 30.4 30 4 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00171301582794472 0.00504683545168807 1.48381900717528 1 30.4 30 4 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605631 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 G2 PHASE%REACTOME%REACT_227891.1 G2 PHASE 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0105732933517194 0.0237315401253891 1.48381900717528 1 30.4 30 4 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.000689458945875915 0.00226059926263002 1.48381900717528 1 30.4 30 4 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.000689458945875915 0.00226059926263002 1.48381900717528 1 30.4 30 4 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000689458945875915 0.00226059926263002 1.48381900717528 1 30.4 30 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 4.98786849649932e-09 6.75974940049383e-08 1.42446624688827 0.96 30.4 30 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 2.74277718554421e-05 0.000129237481292365 1.38489774003026 0.933333333333333 30.4 30 4 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 6.38136354151361e-05 0.000276850009743106 1.37783193523419 0.928571428571429 30.4 30 4 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000147773248033276 0.000585741871730783 1.36967908354641 0.923076923076923 30.4 30 4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000147773248033276 0.000585741871730783 1.36967908354641 0.923076923076923 30.4 30 4 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000340353488728186 0.00123237408259595 1.36016742324401 0.916666666666667 30.4 30 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000340353488728186 0.00123237408259595 1.36016742324401 0.916666666666667 30.4 30 4 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000340353488728186 0.00123237408259595 1.36016742324401 0.916666666666667 30.4 30 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000340353488728186 0.00123237408259595 1.36016742324401 0.916666666666667 30.4 30 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000340353488728186 0.00123237408259595 1.36016742324401 0.916666666666667 30.4 30 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000340353488728186 0.00123237408259595 1.36016742324401 0.916666666666667 30.4 30 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000340353488728186 0.00123237408259595 1.36016742324401 0.916666666666667 30.4 30 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 1.09246170859511e-06 6.87864164305679e-06 1.34892637015935 0.909090909090909 30.4 30 4 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00077899280307769 0.00249663684409809 1.34892637015935 0.909090909090909 30.4 30 4 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00077899280307769 0.00249663684409809 1.34892637015935 0.909090909090909 30.4 30 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00077899280307769 0.00249663684409809 1.34892637015935 0.909090909090909 30.4 30 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00077899280307769 0.00249663684409809 1.34892637015935 0.909090909090909 30.4 30 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00077899280307769 0.00249663684409809 1.34892637015935 0.909090909090909 30.4 30 4 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00176977967840886 0.00508766966136526 1.33543710645775 0.9 30.4 30 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 1.25520498487023e-05 6.66476378160574e-05 1.32762753273578 0.894736842105263 30.4 30 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.2035209557349e-07 1.62466855959107e-06 1.31895022860025 0.888888888888889 30.4 30 4 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00398526623379224 0.0104055666985071 1.31895022860025 0.888888888888889 30.4 30 4 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00398526623379224 0.0104055666985071 1.31895022860025 0.888888888888889 30.4 30 4 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00398526623379224 0.0104055666985071 1.31895022860025 0.888888888888889 30.4 30 4 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00398526623379224 0.0104055666985071 1.31895022860025 0.888888888888889 30.4 30 4 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00398526623379224 0.0104055666985071 1.31895022860025 0.888888888888889 30.4 30 4 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00398526623379224 0.0104055666985071 1.31895022860025 0.888888888888889 30.4 30 4 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00398526623379224 0.0104055666985071 1.31895022860025 0.888888888888889 30.4 30 4 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00398526623379224 0.0104055666985071 1.31895022860025 0.888888888888889 30.4 30 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 6.22393865511591e-05 0.000270846015481038 1.30925206515466 0.882352941176471 30.4 30 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.07857639880358e-06 6.82139651332221e-06 1.30576072631425 0.88 30.4 30 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00013724045615873 0.0005470396893946 1.29834163127837 0.875 30.4 30 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00013724045615873 0.0005470396893946 1.29834163127837 0.875 30.4 30 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00013724045615873 0.0005470396893946 1.29834163127837 0.875 30.4 30 4 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00887791400242637 0.0205085578335272 1.29834163127837 0.875 30.4 30 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.17599042751564e-06 2.9112388847252e-05 1.29027739754372 0.869565217391304 30.4 30 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000300321748553147 0.00111581683600817 1.28597647288524 0.866666666666667 30.4 30 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.12427506321852e-05 5.99192290247172e-05 1.28148005165138 0.863636363636364 30.4 30 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 4.40768996394406e-07 3.05958186277678e-06 1.27915431653042 0.862068965517241 30.4 30 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 2.42653805465925e-05 0.000115871263482554 1.2718448632931 0.857142857142857 30.4 30 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 2.42653805465925e-05 0.000115871263482554 1.2718448632931 0.857142857142857 30.4 30 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000651530923742113 0.00217266706537754 1.2718448632931 0.857142857142857 30.4 30 4 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000651530923742113 0.00217266706537754 1.2718448632931 0.857142857142857 30.4 30 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000651530923742113 0.00217266706537754 1.2718448632931 0.857142857142857 30.4 30 4 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0195134737376937 0.0403014123784299 1.2718448632931 0.857142857142857 30.4 30 4 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0195134737376937 0.0403014123784299 1.2718448632931 0.857142857142857 30.4 30 4 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0195134737376937 0.0403014123784299 1.2718448632931 0.857142857142857 30.4 30 4 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0195134737376937 0.0403014123784299 1.2718448632931 0.857142857142857 30.4 30 4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0195134737376937 0.0403014123784299 1.2718448632931 0.857142857142857 30.4 30 4 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0195134737376937 0.0403014123784299 1.2718448632931 0.857142857142857 30.4 30 4 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0195134737376937 0.0403014123784299 1.2718448632931 0.857142857142857 30.4 30 4 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0195134737376937 0.0403014123784299 1.2718448632931 0.857142857142857 30.4 30 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 8.15639724631353e-08 6.86778300680719e-07 1.26561032964951 0.852941176470588 30.4 30 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 5.20077678027524e-05 0.000229835570134524 1.26124615609899 0.85 30.4 30 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.20077678027524e-05 0.000229835570134524 1.26124615609899 0.85 30.4 30 4 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 5.20077678027524e-05 0.000229835570134524 1.26124615609899 0.85 30.4 30 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 6.23846385919631e-10 9.86370452404039e-09 1.25802046260513 0.847826086956522 30.4 30 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 4.32331410589675e-06 2.48067579543995e-05 1.25553915991755 0.846153846153846 30.4 30 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00139954481255019 0.0041751619879642 1.25553915991755 0.846153846153846 30.4 30 4 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00139954481255019 0.0041751619879642 1.25553915991755 0.846153846153846 30.4 30 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.6259079742378e-06 1.00314935540753e-05 1.23651583931273 0.833333333333333 30.4 30 4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000233259609448465 0.0008758005916759 1.23651583931273 0.833333333333333 30.4 30 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000233259609448465 0.0008758005916759 1.23651583931273 0.833333333333333 30.4 30 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.92104177004884e-05 9.83324618266008e-05 1.23651583931273 0.833333333333333 30.4 30 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 1.92104177004884e-05 9.83324618266008e-05 1.23651583931273 0.833333333333333 30.4 30 4 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00297218937482519 0.00801027553101563 1.23651583931273 0.833333333333333 30.4 30 4 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00297218937482519 0.00801027553101563 1.23651583931273 0.833333333333333 30.4 30 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00297218937482519 0.00801027553101563 1.23651583931273 0.833333333333333 30.4 30 4 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00297218937482519 0.00801027553101563 1.23651583931273 0.833333333333333 30.4 30 4 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 SYNTHESIS OF LIPOXINS (LX)%REACTOME%REACT_196544.2 SYNTHESIS OF LIPOXINS (LX) 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.042160068177915 0.0769150987399655 1.23651583931273 0.833333333333333 30.4 30 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 4.62642751756098e-09 6.33019842066276e-08 1.22576352766654 0.826086956521739 30.4 30 4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 4.00598616043649e-05 0.000183887687300036 1.22576352766654 0.826086956521739 30.4 30 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 4.00598616043649e-05 0.000183887687300036 1.22576352766654 0.826086956521739 30.4 30 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 4.00598616043649e-05 0.000183887687300036 1.22576352766654 0.826086956521739 30.4 30 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.45403629933706e-10 1.29355845741469e-08 1.22196859414435 0.823529411764706 30.4 30 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 8.45403629933706e-10 1.29355845741469e-08 1.22196859414435 0.823529411764706 30.4 30 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000487245447660726 0.00168698363022193 1.22196859414435 0.823529411764706 30.4 30 4 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000487245447660726 0.00168698363022193 1.22196859414435 0.823529411764706 30.4 30 4 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000487245447660726 0.00168698363022193 1.22196859414435 0.823529411764706 30.4 30 4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000487245447660726 0.00168698363022193 1.22196859414435 0.823529411764706 30.4 30 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.54910764535807e-10 2.75547522418066e-09 1.21885132732255 0.821428571428571 30.4 30 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 8.28672151614259e-05 0.000349911119212787 1.21403373314341 0.818181818181818 30.4 30 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 8.28672151614259e-05 0.000349911119212787 1.21403373314341 0.818181818181818 30.4 30 4 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00622832061739912 0.0153072542980293 1.21403373314341 0.818181818181818 30.4 30 4 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00622832061739912 0.0153072542980293 1.21403373314341 0.818181818181818 30.4 30 4 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00622832061739912 0.0153072542980293 1.21403373314341 0.818181818181818 30.4 30 4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00622832061739912 0.0153072542980293 1.21403373314341 0.818181818181818 30.4 30 4 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00622832061739912 0.0153072542980293 1.21403373314341 0.818181818181818 30.4 30 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 3.55979391221672e-09 5.01543241295485e-08 1.2112808221839 0.816326530612245 30.4 30 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.1768666768613e-11 4.48939316112121e-10 1.20560294332992 0.8125 30.4 30 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00100700734892895 0.00307504604619292 1.20560294332992 0.8125 30.4 30 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00100700734892895 0.00307504604619292 1.20560294332992 0.8125 30.4 30 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00100700734892895 0.00307504604619292 1.20560294332992 0.8125 30.4 30 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00100700734892895 0.00307504604619292 1.20560294332992 0.8125 30.4 30 4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00100700734892895 0.00307504604619292 1.20560294332992 0.8125 30.4 30 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.23734451197802e-14 4.89094789040201e-13 1.20451189994229 0.811764705882353 30.4 30 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.23734451197802e-14 4.89094789040201e-13 1.20451189994229 0.811764705882353 30.4 30 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.23734451197802e-14 4.89094789040201e-13 1.20451189994229 0.811764705882353 30.4 30 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 4.41605816234455e-11 8.49196049326527e-10 1.20118681533237 0.80952380952381 30.4 30 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000169912913641432 0.00065524681873105 1.20118681533237 0.80952380952381 30.4 30 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000169912913641432 0.00065524681873105 1.20118681533237 0.80952380952381 30.4 30 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000169912913641432 0.00065524681873105 1.20118681533237 0.80952380952381 30.4 30 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 2.9392856687831e-05 0.000138039719692355 1.19846919810311 0.807692307692308 30.4 30 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 9.19171825293627e-07 5.90323790553389e-06 1.19529864466898 0.805555555555556 30.4 30 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 9.19171825293627e-07 5.90323790553389e-06 1.19529864466898 0.805555555555556 30.4 30 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 7.58813333033344e-14 2.57093184025345e-12 1.18705520574023 0.8 30.4 30 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 5.947456855429e-05 0.000259608316112744 1.18705520574023 0.8 30.4 30 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 5.947456855429e-05 0.000259608316112744 1.18705520574023 0.8 30.4 30 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000345033428594027 0.00124299384528937 1.18705520574023 0.8 30.4 30 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000345033428594027 0.00124299384528937 1.18705520574023 0.8 30.4 30 4 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00205636762449799 0.00582910583597736 1.18705520574023 0.8 30.4 30 4 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00205636762449799 0.00582910583597736 1.18705520574023 0.8 30.4 30 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00205636762449799 0.00582910583597736 1.18705520574023 0.8 30.4 30 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00205636762449799 0.00582910583597736 1.18705520574023 0.8 30.4 30 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00205636762449799 0.00582910583597736 1.18705520574023 0.8 30.4 30 4 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0128472124553258 0.0279962991178079 1.18705520574023 0.8 30.4 30 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.19637743431564e-07 9.72825765160664e-07 1.18031057388943 0.795454545454545 30.4 30 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.68010781745622e-24 5.1229180186463e-22 1.17778133694538 0.79375 30.4 30 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 4.31326160233151e-08 3.69745256633598e-07 1.1746900473471 0.791666666666667 30.4 30 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000119287748439096 0.000486379558821874 1.1746900473471 0.791666666666667 30.4 30 4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000119287748439096 0.000486379558821874 1.1746900473471 0.791666666666667 30.4 30 4 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000119287748439096 0.000486379558821874 1.1746900473471 0.791666666666667 30.4 30 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.000119287748439096 0.000486379558821874 1.1746900473471 0.791666666666667 30.4 30 4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000693184770026428 0.00226759063850025 1.17143605829628 0.789473684210526 30.4 30 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.48280196189817e-11 6.78907834490561e-10 1.17033611833543 0.788732394366197 30.4 30 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0041422624048465 0.0106977121635146 1.16585779135201 0.785714285714286 30.4 30 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0041422624048465 0.0106977121635146 1.16585779135201 0.785714285714286 30.4 30 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0041422624048465 0.0106977121635146 1.16585779135201 0.785714285714286 30.4 30 4 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0041422624048465 0.0106977121635146 1.16585779135201 0.785714285714286 30.4 30 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0041422624048465 0.0106977121635146 1.16585779135201 0.785714285714286 30.4 30 4 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0041422624048465 0.0106977121635146 1.16585779135201 0.785714285714286 30.4 30 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 4.70592369053522e-07 3.25074243283088e-06 1.16585779135201 0.785714285714286 30.4 30 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.68055303276533e-07 1.31397086023355e-06 1.16124965778935 0.782608695652174 30.4 30 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000236973687966845 0.000887404099939002 1.16124965778935 0.782608695652174 30.4 30 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.45452831585715e-05 7.60953600538501e-05 1.15923359935569 0.78125 30.4 30 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 9.25103340080152e-07 5.90323790553389e-06 1.15810263974656 0.780487804878049 30.4 30 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 9.25103340080152e-07 5.90323790553389e-06 1.15810263974656 0.780487804878049 30.4 30 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 3.28982846713556e-07 2.40073123524815e-06 1.15408145002522 0.777777777777778 30.4 30 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 5.11718205481418e-06 2.88958335873039e-05 1.15408145002522 0.777777777777778 30.4 30 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 5.11718205481418e-06 2.88958335873039e-05 1.15408145002522 0.777777777777778 30.4 30 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 8.18375144223283e-05 0.000347626217979024 1.15408145002522 0.777777777777778 30.4 30 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 8.18375144223283e-05 0.000347626217979024 1.15408145002522 0.777777777777778 30.4 30 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 8.18375144223283e-05 0.000347626217979024 1.15408145002522 0.777777777777778 30.4 30 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 8.18375144223283e-05 0.000347626217979024 1.15408145002522 0.777777777777778 30.4 30 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00137619588140365 0.00412279313523661 1.15408145002522 0.777777777777778 30.4 30 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00137619588140365 0.00412279313523661 1.15408145002522 0.777777777777778 30.4 30 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00137619588140365 0.00412279313523661 1.15408145002522 0.777777777777778 30.4 30 4 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0260021811926458 0.0517694950864935 1.15408145002522 0.777777777777778 30.4 30 4 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0260021811926458 0.0517694950864935 1.15408145002522 0.777777777777778 30.4 30 4 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0260021811926458 0.0517694950864935 1.15408145002522 0.777777777777778 30.4 30 4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0260021811926458 0.0517694950864935 1.15408145002522 0.777777777777778 30.4 30 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.12886368325024e-10 8.20041912501696e-09 1.15162072198679 0.776119402985075 30.4 30 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 7.71577579689331e-09 9.63118329735016e-08 1.15123888487737 0.775862068965517 30.4 30 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 7.71577579689331e-09 9.63118329735016e-08 1.15123888487737 0.775862068965517 30.4 30 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.17236025859613e-07 9.58775085047297e-07 1.15071678107471 0.775510204081633 30.4 30 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.80715108138545e-06 1.09896409778269e-05 1.14995973056084 0.775 30.4 30 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.02937967163007e-13 8.9808484848533e-12 1.14876310232925 0.774193548387097 30.4 30 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 4.6339216594855e-11 8.79209402859715e-10 1.14139923628868 0.769230769230769 30.4 30 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000159746941442486 0.000624505213386423 1.14139923628868 0.769230769230769 30.4 30 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000159746941442486 0.000624505213386423 1.14139923628868 0.769230769230769 30.4 30 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000159746941442486 0.000624505213386423 1.14139923628868 0.769230769230769 30.4 30 4 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00821433791574186 0.0196453829480683 1.14139923628868 0.769230769230769 30.4 30 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.4778149418763e-16 1.25926095081785e-14 1.14045593113472 0.768595041322314 30.4 30 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.4778149418763e-16 1.25926095081785e-14 1.14045593113472 0.768595041322314 30.4 30 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.6695675276788e-11 3.64591351057928e-10 1.14000728600052 0.768292682926829 30.4 30 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 5.52934315141837e-05 0.000242847385940381 1.13759457216772 0.766666666666667 30.4 30 4 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 5.52934315141837e-05 0.000242847385940381 1.13759457216772 0.766666666666667 30.4 30 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 4.38669465632251e-07 3.05958186277678e-06 1.13654221826192 0.765957446808511 30.4 30 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.38669465632251e-07 3.05958186277678e-06 1.13654221826192 0.765957446808511 30.4 30 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.38669465632251e-07 3.05958186277678e-06 1.13654221826192 0.765957446808511 30.4 30 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.15409440400077e-11 2.64883280144049e-10 1.13468512313404 0.764705882352941 30.4 30 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.15409440400077e-11 2.64883280144049e-10 1.13468512313404 0.764705882352941 30.4 30 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.55820912089636e-07 1.22504507129035e-06 1.13468512313404 0.764705882352941 30.4 30 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00269623352805069 0.00736418485684478 1.13468512313404 0.764705882352941 30.4 30 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00269623352805069 0.00736418485684478 1.13468512313404 0.764705882352941 30.4 30 4 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00269623352805069 0.00736418485684478 1.13468512313404 0.764705882352941 30.4 30 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00269623352805069 0.00736418485684478 1.13468512313404 0.764705882352941 30.4 30 4 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00269623352805069 0.00736418485684478 1.13468512313404 0.764705882352941 30.4 30 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 5.65567245603167e-18 3.83239138330146e-16 1.13154542993223 0.762589928057554 30.4 30 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.000905419076442332 0.0028254634775821 1.13052876737164 0.761904761904762 30.4 30 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000905419076442332 0.0028254634775821 1.13052876737164 0.761904761904762 30.4 30 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000905419076442332 0.0028254634775821 1.13052876737164 0.761904761904762 30.4 30 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000905419076442332 0.0028254634775821 1.13052876737164 0.761904761904762 30.4 30 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000905419076442332 0.0028254634775821 1.13052876737164 0.761904761904762 30.4 30 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 8.23526573987744e-17 4.50722428763292e-15 1.12998524392579 0.761538461538461 30.4 30 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.000308696151407651 0.00113801715920489 1.12770244545321 0.76 30.4 30 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000308696151407651 0.00113801715920489 1.12770244545321 0.76 30.4 30 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000308696151407651 0.00113801715920489 1.12770244545321 0.76 30.4 30 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.16824441415753e-10 2.13129718121302e-09 1.12695114469009 0.759493670886076 30.4 30 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3.69660890523222e-05 0.000171344445346757 1.12410530846612 0.757575757575758 30.4 30 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.55918471008225e-15 7.15716078208723e-14 1.12191193225448 0.75609756097561 30.4 30 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.54149907943183e-06 2.5850212760126e-05 1.12191193225448 0.75609756097561 30.4 30 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.54149907943183e-06 2.5850212760126e-05 1.12191193225448 0.75609756097561 30.4 30 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.8633668623324e-11 5.73883245788592e-10 1.12149111007434 0.755813953488372 30.4 30 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.60228563152912e-06 9.95656093303903e-06 1.12110769431021 0.755555555555556 30.4 30 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.01348685921089e-07 1.53138546092258e-06 1.11986340164172 0.754716981132076 30.4 30 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.16923980229489e-09 1.73315441527669e-08 1.11794582732384 0.753424657534247 30.4 30 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.50532051793697e-10 2.71148240129659e-09 1.11744394367521 0.753086419753086 30.4 30 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000202742763828828 0.000769341207809124 1.11286425538146 0.75 30.4 30 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000202742763828828 0.000769341207809124 1.11286425538146 0.75 30.4 30 4 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000202742763828828 0.000769341207809124 1.11286425538146 0.75 30.4 30 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.83380850647465e-10 4.80060655323027e-09 1.11286425538146 0.75 30.4 30 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 6.15155851889601e-09 8.07144522504665e-08 1.11286425538146 0.75 30.4 30 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 3.03247593337448e-06 1.76853002179995e-05 1.11286425538146 0.75 30.4 30 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 3.03247593337448e-06 1.76853002179995e-05 1.11286425538146 0.75 30.4 30 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 2.45272861022024e-05 0.00011634109374478 1.11286425538146 0.75 30.4 30 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 2.45272861022024e-05 0.00011634109374478 1.11286425538146 0.75 30.4 30 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000590031506550089 0.00200385401866534 1.11286425538146 0.75 30.4 30 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000590031506550089 0.00200385401866534 1.11286425538146 0.75 30.4 30 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00173763879432363 0.00508766966136526 1.11286425538146 0.75 30.4 30 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00173763879432363 0.00508766966136526 1.11286425538146 0.75 30.4 30 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00520444845120507 0.0132485333561088 1.11286425538146 0.75 30.4 30 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00520444845120507 0.0132485333561088 1.11286425538146 0.75 30.4 30 4 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00520444845120507 0.0132485333561088 1.11286425538146 0.75 30.4 30 4 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00520444845120507 0.0132485333561088 1.11286425538146 0.75 30.4 30 4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00520444845120507 0.0132485333561088 1.11286425538146 0.75 30.4 30 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0159967143451209 0.0336735569720518 1.11286425538146 0.75 30.4 30 4 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0159967143451209 0.0336735569720518 1.11286425538146 0.75 30.4 30 4 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0159967143451209 0.0336735569720518 1.11286425538146 0.75 30.4 30 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.051420152943496 0.0932113090937513 1.11286425538146 0.75 30.4 30 4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.051420152943496 0.0932113090937513 1.11286425538146 0.75 30.4 30 4 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.051420152943496 0.0932113090937513 1.11286425538146 0.75 30.4 30 4 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.051420152943496 0.0932113090937513 1.11286425538146 0.75 30.4 30 4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.051420152943496 0.0932113090937513 1.11286425538146 0.75 30.4 30 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.52767486162859e-24 2.9974011067479e-22 1.10933135298343 0.747619047619048 30.4 30 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.15393296016437e-08 1.33499723765357e-07 1.10732761729499 0.746268656716418 30.4 30 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.15393296016437e-08 1.33499723765357e-07 1.10732761729499 0.746268656716418 30.4 30 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 5.69951949493992e-06 3.16813134425762e-05 1.10423740068858 0.744186046511628 30.4 30 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 5.225212983879e-13 1.51744450531833e-11 1.10265449157062 0.743119266055046 30.4 30 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 6.02545852914257e-08 5.13426795626939e-07 1.10089797306553 0.741935483870968 30.4 30 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000382345304357223 0.00135680141670905 1.09912519050021 0.740740740740741 30.4 30 4 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000382345304357223 0.00135680141670905 1.09912519050021 0.740740740740741 30.4 30 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000382345304357223 0.00135680141670905 1.09912519050021 0.740740740740741 30.4 30 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000382345304357223 0.00135680141670905 1.09912519050021 0.740740740740741 30.4 30 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000382345304357223 0.00135680141670905 1.09912519050021 0.740740740740741 30.4 30 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.688574619013e-12 7.35738785164519e-11 1.09859676492785 0.740384615384615 30.4 30 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.43325171620284e-08 1.48312003024078e-07 1.09673578791216 0.739130434782609 30.4 30 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00111440298990883 0.00338845182615441 1.09673578791216 0.739130434782609 30.4 30 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 4.00171373385792e-08 3.4511749353211e-07 1.09574326683713 0.738461538461539 30.4 30 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 5.94430813212532e-29 9.39861163557148e-27 1.09104338762888 0.735294117647059 30.4 30 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 8.61060528947542e-05 0.000360379156674221 1.09104338762888 0.735294117647059 30.4 30 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 8.61060528947542e-05 0.000360379156674221 1.09104338762888 0.735294117647059 30.4 30 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 8.61060528947542e-05 0.000360379156674221 1.09104338762888 0.735294117647059 30.4 30 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 8.15493103613706e-10 1.27521613894759e-08 1.09051758358665 0.734939759036145 30.4 30 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.29606760351495e-09 8.07144522504665e-08 1.08813393859521 0.733333333333333 30.4 30 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.29606760351495e-09 8.07144522504665e-08 1.08813393859521 0.733333333333333 30.4 30 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.29606760351495e-09 8.07144522504665e-08 1.08813393859521 0.733333333333333 30.4 30 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.29606760351495e-09 8.07144522504665e-08 1.08813393859521 0.733333333333333 30.4 30 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.29606760351495e-09 8.07144522504665e-08 1.08813393859521 0.733333333333333 30.4 30 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.06624039702836e-07 1.53138546092258e-06 1.08813393859521 0.733333333333333 30.4 30 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.06624039702836e-07 1.53138546092258e-06 1.08813393859521 0.733333333333333 30.4 30 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.06624039702836e-07 1.53138546092258e-06 1.08813393859521 0.733333333333333 30.4 30 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.06624039702836e-07 1.53138546092258e-06 1.08813393859521 0.733333333333333 30.4 30 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.06624039702836e-07 1.53138546092258e-06 1.08813393859521 0.733333333333333 30.4 30 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.06624039702836e-07 1.53138546092258e-06 1.08813393859521 0.733333333333333 30.4 30 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.06624039702836e-07 1.53138546092258e-06 1.08813393859521 0.733333333333333 30.4 30 4 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00987847305080494 0.0225273512039991 1.08813393859521 0.733333333333333 30.4 30 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00987847305080494 0.0225273512039991 1.08813393859521 0.733333333333333 30.4 30 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00987847305080494 0.0225273512039991 1.08813393859521 0.733333333333333 30.4 30 4 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00987847305080494 0.0225273512039991 1.08813393859521 0.733333333333333 30.4 30 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00987847305080494 0.0225273512039991 1.08813393859521 0.733333333333333 30.4 30 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.9689890592797e-05 9.93571429558515e-05 1.0857212247624 0.731707317073171 30.4 30 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.9689890592797e-05 9.93571429558515e-05 1.0857212247624 0.731707317073171 30.4 30 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.9689890592797e-05 9.93571429558515e-05 1.0857212247624 0.731707317073171 30.4 30 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.9689890592797e-05 9.93571429558515e-05 1.0857212247624 0.731707317073171 30.4 30 4 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.000712986864170237 0.00232169406799599 1.08432927447424 0.730769230769231 30.4 30 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000712986864170237 0.00232169406799599 1.08432927447424 0.730769230769231 30.4 30 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.09035385378735e-11 6.10774101936027e-10 1.08318787523796 0.73 30.4 30 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 7.40269445818285e-12 1.81621279551624e-10 1.08166245382871 0.728971962616822 30.4 30 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 3.79426794170024e-07 2.69962164051972e-06 1.0814274120091 0.728813559322034 30.4 30 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 3.79426794170024e-07 2.69962164051972e-06 1.0814274120091 0.728813559322034 30.4 30 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 3.79426794170024e-07 2.69962164051972e-06 1.0814274120091 0.728813559322034 30.4 30 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 5.64074488982269e-11 1.0561552602918e-09 1.07914109612748 0.727272727272727 30.4 30 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.06036733931263e-06 6.7361728742941e-06 1.07914109612748 0.727272727272727 30.4 30 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000159116779574829 0.000624505213386423 1.07914109612748 0.727272727272727 30.4 30 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.000159116779574829 0.000624505213386423 1.07914109612748 0.727272727272727 30.4 30 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00207755451102602 0.00584260883239137 1.07914109612748 0.727272727272727 30.4 30 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00207755451102602 0.00584260883239137 1.07914109612748 0.727272727272727 30.4 30 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00207755451102602 0.00584260883239137 1.07914109612748 0.727272727272727 30.4 30 4 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0304975906897968 0.0588049750021421 1.07914109612748 0.727272727272727 30.4 30 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.10929838839713e-08 2.14395114763508e-07 1.07729325178479 0.726027397260274 30.4 30 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 3.61628707393215e-05 0.000168169166869459 1.07576878020208 0.725 30.4 30 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.02583661076391e-10 1.89579934690526e-09 1.07501172968821 0.724489795918367 30.4 30 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00045566252035001 0.00159706346418242 1.07448962588555 0.724137931034483 30.4 30 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.97510046646433e-17 1.22198607120815e-15 1.07358669342682 0.723529411764706 30.4 30 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.83281386517842e-08 3.34607001849625e-07 1.0716470607377 0.722222222222222 30.4 30 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.93252648556953e-06 1.16033130336094e-05 1.0716470607377 0.722222222222222 30.4 30 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00612833140933302 0.0151927100966566 1.0716470607377 0.722222222222222 30.4 30 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00612833140933302 0.0151927100966566 1.0716470607377 0.722222222222222 30.4 30 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00612833140933302 0.0151927100966566 1.0716470607377 0.722222222222222 30.4 30 4 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00612833140933302 0.0151927100966566 1.0716470607377 0.722222222222222 30.4 30 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00612833140933302 0.0151927100966566 1.0716470607377 0.722222222222222 30.4 30 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00612833140933302 0.0151927100966566 1.0716470607377 0.722222222222222 30.4 30 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.57332388382257e-17 2.11868328611647e-15 1.0711592832863 0.72189349112426 30.4 30 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 9.0686077562271e-09 1.10295972966762e-07 1.07060358745558 0.721518987341772 30.4 30 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 9.0686077562271e-09 1.10295972966762e-07 1.07060358745558 0.721518987341772 30.4 30 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 9.0686077562271e-09 1.10295972966762e-07 1.07060358745558 0.721518987341772 30.4 30 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 5.39881094122478e-06 3.01274822327955e-05 1.0683496851662 0.72 30.4 30 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00131346527691636 0.00395987518866946 1.0683496851662 0.72 30.4 30 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00131346527691636 0.00395987518866946 1.0683496851662 0.72 30.4 30 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00131346527691636 0.00395987518866946 1.0683496851662 0.72 30.4 30 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.49246006075555e-14 1.27430017088594e-12 1.06749568861531 0.719424460431655 30.4 30 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 6.58527887863872e-05 0.000284828323535043 1.06530595386943 0.717948717948718 30.4 30 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.17772399909495e-16 1.55927629334901e-14 1.06507253889269 0.717791411042945 30.4 30 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.61813239734802e-15 1.6089382504457e-13 1.06405441961912 0.717105263157895 30.4 30 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 8.16516114292922e-07 5.35438908128492e-06 1.06340362180895 0.716666666666667 30.4 30 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.06875181275706e-08 1.25688746244074e-07 1.0624876841502 0.716049382716049 30.4 30 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.06875181275706e-08 1.25688746244074e-07 1.0624876841502 0.716049382716049 30.4 30 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 7.91365932000758e-18 5.11869873289581e-16 1.0621873767211 0.715846994535519 30.4 30 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 5.30055072394726e-07 3.55786966046083e-06 1.05987071941092 0.714285714285714 30.4 30 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000831351655678218 0.00265249642607647 1.05987071941092 0.714285714285714 30.4 30 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.000831351655678218 0.00265249642607647 1.05987071941092 0.714285714285714 30.4 30 4 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0183945266929803 0.0384367275831291 1.05987071941092 0.714285714285714 30.4 30 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0183945266929803 0.0384367275831291 1.05987071941092 0.714285714285714 30.4 30 4 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0183945266929803 0.0384367275831291 1.05987071941092 0.714285714285714 30.4 30 4 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0183945266929803 0.0384367275831291 1.05987071941092 0.714285714285714 30.4 30 4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0183945266929803 0.0384367275831291 1.05987071941092 0.714285714285714 30.4 30 4 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0987765542784683 0.159726178111659 1.05987071941092 0.714285714285714 30.4 30 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 4.23288740139231e-05 0.000193057652954528 1.05987071941092 0.714285714285714 30.4 30 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000185971973275129 0.00071523815667705 1.05987071941092 0.714285714285714 30.4 30 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.88417702369089e-21 4.34386494044509e-19 1.05796960601287 0.713004484304933 30.4 30 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.54258918020933e-09 6.27582951790085e-08 1.05743423499848 0.71264367816092 30.4 30 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.54258918020933e-09 6.27582951790085e-08 1.05743423499848 0.71264367816092 30.4 30 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 6.2916796417717e-06 3.45677997306607e-05 1.05579429356703 0.711538461538462 30.4 30 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000118841358288964 0.000486379558821874 1.05429245246665 0.710526315789474 30.4 30 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000118841358288964 0.000486379558821874 1.05429245246665 0.710526315789474 30.4 30 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000118841358288964 0.000486379558821874 1.05429245246665 0.710526315789474 30.4 30 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000526875239252926 0.00181535948052521 1.05303284380181 0.709677419354839 30.4 30 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.4450287321908e-07 1.14875747816062e-06 1.05103846341582 0.708333333333333 30.4 30 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.4450287321908e-07 1.14875747816062e-06 1.05103846341582 0.708333333333333 30.4 30 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00238787659235148 0.00664960546167545 1.05103846341582 0.708333333333333 30.4 30 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 7.25300431127677e-12 1.81070616402576e-10 1.04953051727032 0.707317073170732 30.4 30 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 2.21708284708696e-08 2.23752403645727e-07 1.04953051727032 0.707317073170732 30.4 30 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.71995847677556e-13 8.23510832436517e-12 1.04927201221681 0.707142857142857 30.4 30 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.71995847677556e-13 8.23510832436517e-12 1.04927201221681 0.707142857142857 30.4 30 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 9.36188158727422e-08 7.74532412714606e-07 1.0485654317372 0.706666666666667 30.4 30 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.97161553916001e-11 4.12589545915395e-10 1.04740165212373 0.705882352941177 30.4 30 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.4383033322082e-08 1.48312003024078e-07 1.04740165212373 0.705882352941177 30.4 30 4 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0112241642667756 0.0251131851440592 1.04740165212373 0.705882352941177 30.4 30 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0112241642667756 0.0251131851440592 1.04740165212373 0.705882352941177 30.4 30 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.81030801865565e-14 6.96234678526215e-13 1.04628263326462 0.705128205128205 30.4 30 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.42840223473924e-23 3.48472598573853e-21 1.0460639744071 0.704980842911877 30.4 30 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.68770888962645e-06 1.03507956770361e-05 1.04597077554979 0.704918032786885 30.4 30 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.000212429988729792 0.000801824599370011 1.04268362666371 0.702702702702703 30.4 30 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 7.0163571289117e-07 4.64384939276342e-06 1.04088796025729 0.701492537313433 30.4 30 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 9.54736532452106e-12 2.26431680946558e-10 1.03984166644567 0.700787401574803 30.4 30 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.37347281292637e-14 8.88803108630059e-13 1.0386733050227 0.7 30.4 30 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.55445320404744e-10 4.37950230043315e-09 1.0386733050227 0.7 30.4 30 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.55445320404744e-10 4.37950230043315e-09 1.0386733050227 0.7 30.4 30 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.64611662244331e-09 2.4148700553988e-08 1.0386733050227 0.7 30.4 30 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.06464848000474e-08 1.25688746244074e-07 1.0386733050227 0.7 30.4 30 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.99053233429326e-05 0.000100089311367467 1.0386733050227 0.7 30.4 30 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000135129264229541 0.000543189104515924 1.0386733050227 0.7 30.4 30 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000135129264229541 0.000543189104515924 1.0386733050227 0.7 30.4 30 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0009427412582844 0.00292270329093399 1.0386733050227 0.7 30.4 30 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0009427412582844 0.00292270329093399 1.0386733050227 0.7 30.4 30 4 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0009427412582844 0.00292270329093399 1.0386733050227 0.7 30.4 30 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00690759945744435 0.0168602298935563 1.0386733050227 0.7 30.4 30 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00690759945744435 0.0168602298935563 1.0386733050227 0.7 30.4 30 4 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00690759945744435 0.0168602298935563 1.0386733050227 0.7 30.4 30 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00690759945744435 0.0168602298935563 1.0386733050227 0.7 30.4 30 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0566971082463925 0.10174020811427 1.0386733050227 0.7 30.4 30 4 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.0566971082463925 0.10174020811427 1.0386733050227 0.7 30.4 30 4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0566971082463925 0.10174020811427 1.0386733050227 0.7 30.4 30 4 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0566971082463925 0.10174020811427 1.0386733050227 0.7 30.4 30 4 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0566971082463925 0.10174020811427 1.0386733050227 0.7 30.4 30 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.35362242973924e-25 6.92564065228995e-23 1.03816688215335 0.699658703071672 30.4 30 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.11042067352109e-35 2.2573265977436e-33 1.03797667638083 0.699530516431925 30.4 30 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.79320426909386e-16 1.79924322497352e-14 1.03786247496413 0.699453551912568 30.4 30 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.9170094741244e-07 2.13964148540156e-06 1.03664067624574 0.698630136986301 30.4 30 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.15538099630133e-14 1.44222125798458e-12 1.03587364651859 0.69811320754717 30.4 30 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 4.47392702609432e-10 7.23454336151388e-09 1.03458939949836 0.697247706422018 30.4 30 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 7.04083431071575e-12 1.78912629002652e-10 1.03417688378883 0.696969696969697 30.4 30 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000594655884158226 0.0020052021875762 1.03417688378883 0.696969696969697 30.4 30 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000594655884158226 0.0020052021875762 1.03417688378883 0.696969696969697 30.4 30 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 8.17063861409001e-06 4.42084363036125e-05 1.03337395142564 0.696428571428571 30.4 30 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 7.93677732131875e-07 5.22871950381324e-06 1.03222191803498 0.695652173913043 30.4 30 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.22662378678194e-18 9.18676657153004e-17 1.0319286731719 0.695454545454545 30.4 30 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 7.96192013652454e-19 6.29434019681912e-17 1.03135401844022 0.695067264573991 30.4 30 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 5.23852350194719e-06 2.93481060758695e-05 1.03112846261333 0.694915254237288 30.4 30 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000375899364337582 0.00135076968548581 1.03042986609395 0.694444444444444 30.4 30 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.26347875979311e-13 4.18123319810604e-12 1.03016733619176 0.694267515923567 30.4 30 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00266454170559516 0.00734814505244556 1.02725931265981 0.692307692307692 30.4 30 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00266454170559516 0.00734814505244556 1.02725931265981 0.692307692307692 30.4 30 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00266454170559516 0.00734814505244556 1.02725931265981 0.692307692307692 30.4 30 4 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0335070613112237 0.0639149440293181 1.02725931265981 0.692307692307692 30.4 30 4 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0335070613112237 0.0639149440293181 1.02725931265981 0.692307692307692 30.4 30 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0335070613112237 0.0639149440293181 1.02725931265981 0.692307692307692 30.4 30 4 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0335070613112237 0.0639149440293181 1.02725931265981 0.692307692307692 30.4 30 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.38068346561635e-11 3.11859138344772e-10 1.02640111774531 0.691729323308271 30.4 30 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.42843264274935e-05 7.50058911672442e-05 1.0251840413211 0.690909090909091 30.4 30 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.1681450376813e-41 1.97709012954016e-38 1.02400437187192 0.690114068441065 30.4 30 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 9.13589054034151e-06 4.90580084487018e-05 1.02332345322433 0.689655172413793 30.4 30 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00166621640085201 0.00492936785532726 1.02332345322433 0.689655172413793 30.4 30 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 5.84703611383697e-06 3.22493503487985e-05 1.02164587379282 0.688524590163934 30.4 30 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.84703611383697e-06 3.22493503487985e-05 1.02164587379282 0.688524590163934 30.4 30 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 3.74448530375169e-06 2.16601731188563e-05 1.02012556743301 0.6875 30.4 30 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.74448530375169e-06 2.16601731188563e-05 1.02012556743301 0.6875 30.4 30 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00104558444748914 0.00318600999738125 1.02012556743301 0.6875 30.4 30 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0201613271699246 0.0413990888352131 1.02012556743301 0.6875 30.4 30 4 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0201613271699246 0.0413990888352131 1.02012556743301 0.6875 30.4 30 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0201613271699246 0.0413990888352131 1.02012556743301 0.6875 30.4 30 4 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0201613271699246 0.0413990888352131 1.02012556743301 0.6875 30.4 30 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 5.02201825268504e-29 8.93291496696351e-27 1.01962963862045 0.687165775401069 30.4 30 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 9.74014084692288e-09 1.1745949512857e-07 1.01918881300928 0.686868686868687 30.4 30 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.51729320045496e-07 1.19950456902634e-06 1.01900823384327 0.686746987951807 30.4 30 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.39938331439715e-06 1.42858680183563e-05 1.01874140791139 0.686567164179104 30.4 30 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 9.75995285965638e-08 8.027984346411e-07 1.01796885375979 0.686046511627907 30.4 30 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.53829552243801e-06 9.6008531948653e-06 1.01747589063448 0.685714285714286 30.4 30 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.000658060087967478 0.00217266706537754 1.01747589063448 0.685714285714286 30.4 30 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000658060087967478 0.00217266706537754 1.01747589063448 0.685714285714286 30.4 30 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000658060087967478 0.00217266706537754 1.01747589063448 0.685714285714286 30.4 30 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000658060087967478 0.00217266706537754 1.01747589063448 0.685714285714286 30.4 30 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.000658060087967478 0.00217266706537754 1.01747589063448 0.685714285714286 30.4 30 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.47874275440614e-05 0.000117184416595347 1.01669080121269 0.685185185185185 30.4 30 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.42310934134686e-15 3.63214684628381e-13 1.01609345056568 0.684782608695652 30.4 30 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 6.33216030458293e-07 4.21059070720631e-06 1.01524458385677 0.684210526315789 30.4 30 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 6.33216030458293e-07 4.21059070720631e-06 1.01524458385677 0.684210526315789 30.4 30 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0122810243108249 0.0271786898822765 1.01524458385677 0.684210526315789 30.4 30 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0122810243108249 0.0271786898822765 1.01524458385677 0.684210526315789 30.4 30 4 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0122810243108249 0.0271786898822765 1.01524458385677 0.684210526315789 30.4 30 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0122810243108249 0.0271786898822765 1.01524458385677 0.684210526315789 30.4 30 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0122810243108249 0.0271786898822765 1.01524458385677 0.684210526315789 30.4 30 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0122810243108249 0.0271786898822765 1.01524458385677 0.684210526315789 30.4 30 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.08566492586025e-09 1.63722849538884e-08 1.01524458385677 0.684210526315789 30.4 30 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 4.06531650933591e-07 2.87808228496766e-06 1.01425603022108 0.683544303797468 30.4 30 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 6.94932122992924e-09 8.82936081266903e-08 1.0129918222062 0.682692307692308 30.4 30 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 6.46010230394852e-06 3.53566368404567e-05 1.01276535410376 0.682539682539683 30.4 30 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.64578524008972e-06 1.55576545316019e-05 1.01071729474258 0.681159420289855 30.4 30 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.64578524008972e-06 1.55576545316019e-05 1.01071729474258 0.681159420289855 30.4 30 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.69482459082882e-06 1.03507956770361e-05 1.00982126877207 0.680555555555556 30.4 30 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 4.26811143473691e-05 0.000194042254684684 1.00787706147755 0.679245283018868 30.4 30 4 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00290617938516064 0.00789216271962518 1.00687718344037 0.678571428571429 30.4 30 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00290617938516064 0.00789216271962518 1.00687718344037 0.678571428571429 30.4 30 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.31520115432319e-11 4.70647320371699e-10 1.00650659927274 0.678321678321678 30.4 30 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 4.01635890707777e-12 1.03914158632212e-10 1.00516771453809 0.67741935483871 30.4 30 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.10695263376223e-05 5.92178044302124e-05 1.00516771453809 0.67741935483871 30.4 30 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.85261114408855e-06 1.11706171950763e-05 1.00258041025357 0.675675675675676 30.4 30 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.85261114408855e-06 1.11706171950763e-05 1.00258041025357 0.675675675675676 30.4 30 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000716460563520482 0.0023223767241222 1.00258041025357 0.675675675675676 30.4 30 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000716460563520482 0.0023223767241222 1.00258041025357 0.675675675675676 30.4 30 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000451856573276372 0.00158763433030192 1.00157782984332 0.675 30.4 30 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.84954627569815e-10 6.29644178197525e-09 1.00071514437403 0.674418604651163 30.4 30 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 2.00981954359121e-07 1.53138546092258e-06 1.00032742056761 0.674157303370786 30.4 30 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.29068220485847e-07 1.04354589631454e-06 0.999964983096386 0.673913043478261 30.4 30 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 8.29172775260666e-08 6.90007519997618e-07 0.999625436412821 0.673684210526316 30.4 30 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 8.29172775260666e-08 6.90007519997618e-07 0.999625436412821 0.673684210526316 30.4 30 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000114744485333947 0.00047743100184271 0.99930667830172 0.673469387755102 30.4 30 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 7.29002282013451e-05 0.000314354620395497 0.998724331752594 0.673076923076923 30.4 30 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.41699151743941e-08 1.48312003024078e-07 0.99845764968804 0.672897196261682 30.4 30 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 4.63771353947836e-05 0.000207530388889236 0.998205513917917 0.672727272727273 30.4 30 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.63771353947836e-05 0.000207530388889236 0.998205513917917 0.672727272727273 30.4 30 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 4.63771353947836e-05 0.000207530388889236 0.998205513917917 0.672727272727273 30.4 30 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 4.63771353947836e-05 0.000207530388889236 0.998205513917917 0.672727272727273 30.4 30 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 4.63771353947836e-05 0.000207530388889236 0.998205513917917 0.672727272727273 30.4 30 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 7.41390081417481e-37 1.75833014309513e-34 0.997548733288251 0.672284644194757 30.4 30 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.87489804176345e-14 1.37849497835735e-12 0.996940895445892 0.671875 30.4 30 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 8.06306582144768e-12 1.94470214642713e-10 0.995473511142911 0.670886075949367 30.4 30 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 5.29341466985798e-07 3.55786966046083e-06 0.995031569517542 0.670588235294118 30.4 30 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 5.29341466985798e-07 3.55786966046083e-06 0.995031569517542 0.670588235294118 30.4 30 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 5.29341466985798e-07 3.55786966046083e-06 0.995031569517542 0.670588235294118 30.4 30 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 5.29341466985798e-07 3.55786966046083e-06 0.995031569517542 0.670588235294118 30.4 30 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 5.29341466985798e-07 3.55786966046083e-06 0.995031569517542 0.670588235294118 30.4 30 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 3.3961265473467e-07 2.45314115577378e-06 0.994833197992518 0.670454545454545 30.4 30 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.69705238747276e-09 2.41490554737374e-08 0.993201432222164 0.669354838709677 30.4 30 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.69705238747276e-09 2.41490554737374e-08 0.993201432222164 0.669354838709677 30.4 30 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.69705238747276e-09 2.41490554737374e-08 0.993201432222164 0.669354838709677 30.4 30 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.09301972636641e-09 1.63722849538884e-08 0.993107209526764 0.669291338582677 30.4 30 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.69265885875771e-13 5.47421262730049e-12 0.991857625117167 0.668449197860963 30.4 30 4 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00122238153522727 0.00370884632116931 0.989212671450188 0.666666666666667 30.4 30 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00194744157415097 0.00557587396381656 0.989212671450188 0.666666666666667 30.4 30 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0214158299816607 0.0437227059740361 0.989212671450188 0.666666666666667 30.4 30 4 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0214158299816607 0.0437227059740361 0.989212671450188 0.666666666666667 30.4 30 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.102256096445196 0.161241252629756 0.989212671450188 0.666666666666667 30.4 30 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.57672334569048e-08 2.58216712740672e-07 0.989212671450188 0.666666666666667 30.4 30 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 8.90108959074859e-07 5.78367602175125e-06 0.989212671450188 0.666666666666667 30.4 30 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 8.90108959074859e-07 5.78367602175125e-06 0.989212671450188 0.666666666666667 30.4 30 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.18122327668611e-05 0.000148910550089616 0.989212671450188 0.666666666666667 30.4 30 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 7.84684879539844e-05 0.000337343378726646 0.989212671450188 0.666666666666667 30.4 30 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000194558493747855 0.000744238539255906 0.989212671450188 0.666666666666667 30.4 30 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000194558493747855 0.000744238539255906 0.989212671450188 0.666666666666667 30.4 30 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000485583228411241 0.00168698363022193 0.989212671450188 0.666666666666667 30.4 30 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00311316668598722 0.00837435953527375 0.989212671450188 0.666666666666667 30.4 30 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00499710397933322 0.0128355215931249 0.989212671450188 0.666666666666667 30.4 30 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00499710397933322 0.0128355215931249 0.989212671450188 0.666666666666667 30.4 30 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00806137792175019 0.0195756668645913 0.989212671450188 0.666666666666667 30.4 30 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.00806137792175019 0.0195756668645913 0.989212671450188 0.666666666666667 30.4 30 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0130864221942793 0.0284305019579533 0.989212671450188 0.666666666666667 30.4 30 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.035426633977331 0.0666826721557434 0.989212671450188 0.666666666666667 30.4 30 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.035426633977331 0.0666826721557434 0.989212671450188 0.666666666666667 30.4 30 4 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.035426633977331 0.0666826721557434 0.989212671450188 0.666666666666667 30.4 30 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.035426633977331 0.0666826721557434 0.989212671450188 0.666666666666667 30.4 30 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.035426633977331 0.0666826721557434 0.989212671450188 0.666666666666667 30.4 30 4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0594993433791487 0.104916438201399 0.989212671450188 0.666666666666667 30.4 30 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 8.85586443410159e-06 4.77344510974491e-05 0.982246385031525 0.661971830985915 30.4 30 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.39944461625851e-05 0.000158603596358553 0.981235149906235 0.661290322580645 30.4 30 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.13076343554786e-12 8.25014142367518e-11 0.980829513217559 0.661016949152542 30.4 30 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.7312612648487e-07 1.34622119119109e-06 0.979320544735686 0.66 30.4 30 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000207281473836223 0.000784472173587619 0.979320544735686 0.66 30.4 30 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000516225616161368 0.00178298313543113 0.977971618365527 0.659090909090909 30.4 30 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 7.24070381145207e-17 4.12140860947852e-15 0.97589634702682 0.657692307692308 30.4 30 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.47252533601073e-05 7.6754708906347e-05 0.975081061858042 0.657142857142857 30.4 30 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00206064824537027 0.00582962714346302 0.975081061858042 0.657142857142857 30.4 30 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00328696757697674 0.0088251978529017 0.973756223458779 0.65625 30.4 30 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 8.86835289021782e-05 0.000370078186591788 0.972157280563116 0.655172413793103 30.4 30 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00526210905534706 0.013347560045916 0.972157280563116 0.655172413793103 30.4 30 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00526210905534706 0.013347560045916 0.972157280563116 0.655172413793103 30.4 30 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 4.09027703058727e-06 2.35646324474724e-05 0.970893918275184 0.654320987654321 30.4 30 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00846097862042342 0.0201001211633765 0.970189350845377 0.653846153846154 30.4 30 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00846097862042342 0.0201001211633765 0.970189350845377 0.653846153846154 30.4 30 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00846097862042342 0.0201001211633765 0.970189350845377 0.653846153846154 30.4 30 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00846097862042342 0.0201001211633765 0.970189350845377 0.653846153846154 30.4 30 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.47034372730176e-08 1.50525116830964e-07 0.969268867590305 0.653225806451613 30.4 30 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.55583518547922e-05 8.08012214940487e-05 0.968604074128309 0.652777777777778 30.4 30 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.11342591350111e-13 6.68312238869351e-12 0.96801525706197 0.652380952380952 30.4 30 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000543712534212068 0.00186434442453921 0.967708048157793 0.652173913043478 30.4 30 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000543712534212068 0.00186434442453921 0.967708048157793 0.652173913043478 30.4 30 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0136776299646029 0.0294822334197434 0.967708048157793 0.652173913043478 30.4 30 4 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0136776299646029 0.0294822334197434 0.967708048157793 0.652173913043478 30.4 30 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 3.17647997189248e-10 5.25596627907325e-09 0.966875611127119 0.651612903225806 30.4 30 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000858866730204335 0.002728052136341 0.966207725602509 0.651162790697674 30.4 30 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000858866730204335 0.002728052136341 0.966207725602509 0.651162790697674 30.4 30 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.8969598508253e-12 7.77806390136679e-11 0.966027999463074 0.651041666666667 30.4 30 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.86982614521161e-51 2.04188130231806e-48 0.965153765979397 0.650452488687783 30.4 30 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0222602418956745 0.0452518917393498 0.964482354663933 0.65 30.4 30 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0222602418956745 0.0452518917393498 0.964482354663933 0.65 30.4 30 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.39402537207508e-07 1.12073339235189e-06 0.962477193843426 0.648648648648649 30.4 30 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.90970945222491e-13 1.68190331010321e-11 0.960949452265897 0.647619047619048 30.4 30 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.35897122188794e-07 2.43868165752374e-06 0.960949452265897 0.647619047619048 30.4 30 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.92152657026558e-08 3.40264165212678e-07 0.960833619400387 0.647540983606557 30.4 30 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00342968079035797 0.00915653989620898 0.960118181113418 0.647058823529412 30.4 30 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00342968079035797 0.00915653989620898 0.960118181113418 0.647058823529412 30.4 30 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00342968079035797 0.00915653989620898 0.960118181113418 0.647058823529412 30.4 30 4 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0365461258256977 0.0678033077574548 0.960118181113418 0.647058823529412 30.4 30 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000568042533517278 0.00193842811797383 0.958299775467369 0.645833333333333 30.4 30 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000568042533517278 0.00193842811797383 0.958299775467369 0.645833333333333 30.4 30 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00547154266369032 0.0138541017979205 0.957302585274375 0.645161290322581 30.4 30 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.70966998793529e-05 8.81471156823157e-05 0.956672780941958 0.644736842105263 30.4 30 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 6.36381451297111e-08 5.39030241187969e-07 0.956511426112992 0.644628099173554 30.4 30 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00089530016035014 0.00282486059463026 0.956238915735182 0.644444444444444 30.4 30 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00876076824884386 0.0205085578335272 0.953883647469824 0.642857142857143 30.4 30 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00876076824884386 0.0205085578335272 0.953883647469824 0.642857142857143 30.4 30 4 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.060709623624062 0.106539138328792 0.953883647469824 0.642857142857143 30.4 30 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.060709623624062 0.106539138328792 0.953883647469824 0.642857142857143 30.4 30 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 4.15828320400335e-05 0.000190264855282854 0.953883647469824 0.642857142857143 30.4 30 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.03940313894865e-06 1.21935742299325e-05 0.95276799408097 0.642105263157895 30.4 30 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00223564164443462 0.00627478907303838 0.951166030240565 0.641025641025641 30.4 30 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0140887153157041 0.0300573341742833 0.94964416459218 0.64 30.4 30 4 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0140887153157041 0.0300573341742833 0.94964416459218 0.64 30.4 30 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0140887153157041 0.0300573341742833 0.94964416459218 0.64 30.4 30 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0140887153157041 0.0300573341742833 0.94964416459218 0.64 30.4 30 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.90965740045876e-06 4.29597041253924e-05 0.944248459111543 0.636363636363636 30.4 30 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.0227784559609677 0.0461077422936801 0.944248459111543 0.636363636363636 30.4 30 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0227784559609677 0.0461077422936801 0.944248459111543 0.636363636363636 30.4 30 4 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.102546263970435 0.161241252629756 0.944248459111543 0.636363636363636 30.4 30 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000607481948792766 0.00204360948730994 0.94165436993816 0.634615384615385 30.4 30 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00229953568427963 0.00642876086194481 0.940958394794081 0.634146341463415 30.4 30 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00229953568427963 0.00642876086194481 0.940958394794081 0.634146341463415 30.4 30 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.8226318594343e-39 8.03321027195001e-37 0.938548770223546 0.632522407170295 30.4 30 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.26458366428712e-05 6.6896005735337e-05 0.938046498788971 0.632183908045977 30.4 30 4 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0370754968459506 0.0686958750153486 0.93714884663702 0.631578947368421 30.4 30 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000168053986683687 0.000653390226914991 0.935947373756716 0.630769230769231 30.4 30 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00149506728729155 0.00445079654773196 0.935451113219199 0.630434782608696 30.4 30 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0143495655102768 0.0304313438466824 0.934256411925177 0.62962962962963 30.4 30 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0143495655102768 0.0304313438466824 0.934256411925177 0.62962962962963 30.4 30 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.000973824446159341 0.00301250475409727 0.931023690776647 0.627450980392157 30.4 30 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.62844343709866e-06 1.00314935540753e-05 0.927386879484551 0.625 30.4 30 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.023038050036024 0.0465669676154293 0.927386879484551 0.625 30.4 30 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0608688119896751 0.106539138328792 0.927386879484551 0.625 30.4 30 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0608688119896751 0.106539138328792 0.927386879484551 0.625 30.4 30 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0608688119896751 0.106539138328792 0.927386879484551 0.625 30.4 30 4 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%REACT_208465.1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 EARLY STAGE PANCREATIC PRECURSOR CELLS%REACTOME%REACT_13403.1 EARLY STAGE PANCREATIC PRECURSOR CELLS 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.177703889836755 0.252305063509619 0.927386879484551 0.625 30.4 30 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.55861624908545e-72 6.4869109224486e-69 0.925351298212603 0.623628147191737 30.4 30 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000990649032510999 0.00305790362963807 0.923887306354421 0.622641509433962 30.4 30 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.01935536978058e-26 5.71954269119777e-24 0.91991581180394 0.619964973730298 30.4 30 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0037394440378161 0.00992766579442596 0.91855462348946 0.619047619047619 30.4 30 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00918733832214044 0.0211204885822389 0.916476445608262 0.617647058823529 30.4 30 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.04028793896816e-05 0.000224837922794724 0.914446597445232 0.616279069767442 30.4 30 4 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0058653674186066 0.0147468578949428 0.913119389030943 0.615384615384615 30.4 30 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00155997244194586 0.004624668301852 0.913119389030943 0.615384615384615 30.4 30 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00155997244194586 0.004624668301852 0.913119389030943 0.615384615384615 30.4 30 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0230930940281532 0.0466120181589533 0.913119389030943 0.615384615384615 30.4 30 4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.101086994687829 0.161241252629756 0.913119389030943 0.615384615384615 30.4 30 4 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.101086994687829 0.161241252629756 0.913119389030943 0.615384615384615 30.4 30 4 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.101086994687829 0.161241252629756 0.913119389030943 0.615384615384615 30.4 30 4 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.101086994687829 0.161241252629756 0.913119389030943 0.615384615384615 30.4 30 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0145193471720834 0.0306998975124438 0.909437456010657 0.612903225806452 30.4 30 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.71662828678012e-11 3.64591351057928e-10 0.906778282162672 0.611111111111111 30.4 30 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.71662828678012e-11 3.64591351057928e-10 0.906778282162672 0.611111111111111 30.4 30 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.71662828678012e-11 3.64591351057928e-10 0.906778282162672 0.611111111111111 30.4 30 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0603223050091845 0.106235940628799 0.906778282162672 0.611111111111111 30.4 30 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00587823551138126 0.0147526086996394 0.904767687302001 0.609756097560976 30.4 30 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00377213376425449 0.00999580325239133 0.903194178280606 0.608695652173913 30.4 30 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.000431002551885606 0.00151811047359707 0.903194178280606 0.608695652173913 30.4 30 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.29145536993009e-18 9.18870495705261e-17 0.901603029023546 0.60762331838565 30.4 30 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.67073750591367e-40 1.30586486772879e-37 0.901579717072469 0.607607607607608 30.4 30 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0144684443101993 0.0306377920437703 0.899284246772898 0.606060606060606 30.4 30 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.88311953729801e-20 4.08745829504416e-18 0.898735902719988 0.605691056910569 30.4 30 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00918287391050843 0.0211204885822389 0.898100978027144 0.605263157894737 30.4 30 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0058655808633434 0.0147468578949428 0.897192888059473 0.604651162790698 30.4 30 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.21496073025282e-06 7.6162516262104e-06 0.894500819928362 0.602836879432624 30.4 30 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0364620521165039 0.0678033077574548 0.890291404305169 0.6 30.4 30 4 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0592983792713649 0.104916438201399 0.890291404305169 0.6 30.4 30 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0592983792713649 0.104916438201399 0.890291404305169 0.6 30.4 30 4 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0592983792713649 0.104916438201399 0.890291404305169 0.6 30.4 30 4 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.170594578743402 0.248980600566011 0.890291404305169 0.6 30.4 30 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 2.23960435664078e-05 0.000107667466199319 0.890291404305169 0.6 30.4 30 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00583101039252075 0.0147119287031153 0.890291404305169 0.6 30.4 30 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.0227537394191435 0.0461077422936801 0.890291404305169 0.6 30.4 30 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0986341080941584 0.159726178111659 0.890291404305169 0.6 30.4 30 4 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00239943850630426 0.00666653665061264 0.885085021823852 0.596491228070175 30.4 30 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00902351709015358 0.0208111261252651 0.883225599509096 0.595238095238095 30.4 30 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.51527064596723e-12 4.22790221413993e-11 0.883008857030689 0.595092024539877 30.4 30 4 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.014172745100249 0.0301913417330154 0.882270761023141 0.594594594594595 30.4 30 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00042184376535731 0.00148953766278772 0.879300152400167 0.592592592592593 30.4 30 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00367671489044633 0.00979768780731298 0.879300152400167 0.592592592592593 30.4 30 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0358109536905188 0.0673170239122962 0.879300152400167 0.592592592592593 30.4 30 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0579521609485712 0.103730723307946 0.876802140603576 0.590909090909091 30.4 30 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00234835324020344 0.00655236600158725 0.875696463250986 0.590163934426229 30.4 30 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0139517894926173 0.029944791022616 0.87507274782132 0.58974358974359 30.4 30 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0139517894926173 0.029944791022616 0.87507274782132 0.58974358974359 30.4 30 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.9368509572018e-10 4.91663401423314e-09 0.873149812886538 0.588447653429603 30.4 30 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0956155065096428 0.156932947823785 0.872834710103107 0.588235294117647 30.4 30 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0350298111509163 0.0664430617260211 0.869824935240682 0.586206896551724 30.4 30 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 2.57224369018542e-06 1.52512615463911e-05 0.869499036051757 0.585987261146497 30.4 30 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0136948392764936 0.0294822334197434 0.868576979809921 0.585365853658537 30.4 30 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0136948392764936 0.0294822334197434 0.868576979809921 0.585365853658537 30.4 30 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.33716458127348e-21 4.11452346610144e-19 0.867676433433757 0.584758942457232 30.4 30 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00859461309457061 0.02038355738929 0.865561087518914 0.583333333333333 30.4 30 4 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0563914413089842 0.10174020811427 0.865561087518914 0.583333333333333 30.4 30 4 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0563914413089842 0.10174020811427 0.865561087518914 0.583333333333333 30.4 30 4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.162811952798236 0.240084361483823 0.865561087518914 0.583333333333333 30.4 30 4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.162811952798236 0.240084361483823 0.865561087518914 0.583333333333333 30.4 30 4 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.162811952798236 0.240084361483823 0.865561087518914 0.583333333333333 30.4 30 4 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.162811952798236 0.240084361483823 0.865561087518914 0.583333333333333 30.4 30 4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.162811952798236 0.240084361483823 0.865561087518914 0.583333333333333 30.4 30 4 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.162811952798236 0.240084361483823 0.865561087518914 0.583333333333333 30.4 30 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000388664569071833 0.00137579522833139 0.861572326746938 0.580645161290323 30.4 30 4 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.0341552056073805 0.0648903305464652 0.861572326746938 0.580645161290323 30.4 30 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0341552056073805 0.0648903305464652 0.861572326746938 0.580645161290323 30.4 30 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000592145083647321 0.0020052021875762 0.859940560976584 0.579545454545455 30.4 30 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000162427635940612 0.000633245276557511 0.859782976120257 0.579439252336449 30.4 30 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0922866662336307 0.151644256409303 0.859053109417269 0.578947368421053 30.4 30 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000885294046389061 0.00279949650669252 0.855378015901045 0.576470588235294 30.4 30 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000885294046389061 0.00279949650669252 0.855378015901045 0.576470588235294 30.4 30 4 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0332153112821501 0.0636999837661719 0.854320034434253 0.575757575757576 30.4 30 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0332153112821501 0.0636999837661719 0.854320034434253 0.575757575757576 30.4 30 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0332153112821501 0.0636999837661719 0.854320034434253 0.575757575757576 30.4 30 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0332153112821501 0.0636999837661719 0.854320034434253 0.575757575757576 30.4 30 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.020489909050934 0.0419527202582433 0.853195929125787 0.575 30.4 30 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 7.35672932157564e-06 4.01096774888971e-05 0.850481626063881 0.573170731707317 30.4 30 4 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00495775023504585 0.0127805771457794 0.847896575528733 0.571428571428571 30.4 30 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0124426316756693 0.0274935789976358 0.847896575528733 0.571428571428571 30.4 30 4 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.154923489439517 0.235781952376934 0.847896575528733 0.571428571428571 30.4 30 4 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.154923489439517 0.235781952376934 0.847896575528733 0.571428571428571 30.4 30 4 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.154923489439517 0.235781952376934 0.847896575528733 0.571428571428571 30.4 30 4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.154923489439517 0.235781952376934 0.847896575528733 0.571428571428571 30.4 30 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00191539188310477 0.00549516663237518 0.84266264605016 0.567901234567901 30.4 30 4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0852740848620289 0.143603577229192 0.83868030840342 0.565217391304348 30.4 30 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000124608571242795 0.000505179478286316 0.838187836114281 0.564885496183206 30.4 30 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000124608571242795 0.000505179478286316 0.838187836114281 0.564885496183206 30.4 30 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0113973898064255 0.0254607310746364 0.836334349498795 0.563636363636364 30.4 30 4 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.147189488799922 0.224973837338657 0.834648191536096 0.5625 30.4 30 4 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.147189488799922 0.224973837338657 0.834648191536096 0.5625 30.4 30 4 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.147189488799922 0.224973837338657 0.834648191536096 0.5625 30.4 30 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.147189488799922 0.224973837338657 0.834648191536096 0.5625 30.4 30 4 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.147189488799922 0.224973837338657 0.834648191536096 0.5625 30.4 30 4 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.147189488799922 0.224973837338657 0.834648191536096 0.5625 30.4 30 4 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.147189488799922 0.224973837338657 0.834648191536096 0.5625 30.4 30 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0817561184630501 0.137842365607725 0.830938644018158 0.56 30.4 30 4 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.139732008385216 0.215660138755057 0.824343892875157 0.555555555555556 30.4 30 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.139732008385216 0.215660138755057 0.824343892875157 0.555555555555556 30.4 30 4 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.272013631576204 0.364477775643068 0.824343892875157 0.555555555555556 30.4 30 4 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.272013631576204 0.364477775643068 0.824343892875157 0.555555555555556 30.4 30 4 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.272013631576204 0.364477775643068 0.824343892875157 0.555555555555556 30.4 30 4 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.272013631576204 0.364477775643068 0.824343892875157 0.555555555555556 30.4 30 4 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.272013631576204 0.364477775643068 0.824343892875157 0.555555555555556 30.4 30 4 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0782943192836976 0.132162296964059 0.824343892875157 0.555555555555556 30.4 30 4 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.074916003525841 0.12660982543619 0.818658762579466 0.551724137931034 30.4 30 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.132605683631956 0.206227199790462 0.816100453946405 0.55 30.4 30 4 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.132605683631956 0.206227199790462 0.816100453946405 0.55 30.4 30 4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.132605683631956 0.206227199790462 0.816100453946405 0.55 30.4 30 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0716384794353428 0.121214692314498 0.813707197483219 0.548387096774194 30.4 30 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0136436844996495 0.0294822334197434 0.811463519548982 0.546875 30.4 30 4 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.125830503650758 0.196549732925389 0.809355822095608 0.545454545454545 30.4 30 4 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.252252556470963 0.340295851515385 0.809355822095608 0.545454545454545 30.4 30 4 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.252252556470963 0.340295851515385 0.809355822095608 0.545454545454545 30.4 30 4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.252252556470963 0.340295851515385 0.809355822095608 0.545454545454545 30.4 30 4 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.252252556470963 0.340295851515385 0.809355822095608 0.545454545454545 30.4 30 4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.252252556470963 0.340295851515385 0.809355822095608 0.545454545454545 30.4 30 4 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.252252556470963 0.340295851515385 0.809355822095608 0.545454545454545 30.4 30 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.3840100794467e-10 4.1882053617934e-09 0.803360593783789 0.541414141414141 30.4 30 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.32404025898112e-05 6.9781825501116e-05 0.802408561820109 0.540772532188841 30.4 30 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0624937025588046 0.109114771461569 0.802064328202855 0.540540540540541 30.4 30 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00371594234347809 0.00988371206498939 0.801262263874652 0.54 30.4 30 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0341018609269987 0.0648903305464652 0.801262263874652 0.54 30.4 30 4 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.113330398908614 0.177609204457002 0.798979465402075 0.538461538461538 30.4 30 4 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.234824403927044 0.319459968248741 0.798979465402075 0.538461538461538 30.4 30 4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.234824403927044 0.319459968248741 0.798979465402075 0.538461538461538 30.4 30 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.234824403927044 0.319459968248741 0.798979465402075 0.538461538461538 30.4 30 4 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.234824403927044 0.319459968248741 0.798979465402075 0.538461538461538 30.4 30 4 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.234824403927044 0.319459968248741 0.798979465402075 0.538461538461538 30.4 30 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.00550750216507287 0.0139203829145625 0.796576519641467 0.536842105263158 30.4 30 4 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.107584116431309 0.168789633607225 0.794903039558187 0.535714285714286 30.4 30 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0286955061513793 0.0562447730763262 0.793075676248858 0.53448275862069 30.4 30 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0286955061513793 0.0562447730763262 0.793075676248858 0.53448275862069 30.4 30 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0286955061513793 0.0562447730763262 0.793075676248858 0.53448275862069 30.4 30 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.56431634479768e-05 8.094626031444e-05 0.79137013716015 0.533333333333333 30.4 30 4 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.10215356672882 0.161241252629756 0.79137013716015 0.533333333333333 30.4 30 4 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.219254210977071 0.300576822948335 0.79137013716015 0.533333333333333 30.4 30 4 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.219254210977071 0.300576822948335 0.79137013716015 0.533333333333333 30.4 30 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.219254210977071 0.300576822948335 0.79137013716015 0.533333333333333 30.4 30 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.013658098751295 0.0294822334197434 0.788865801283061 0.531645569620253 30.4 30 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0970220718125028 0.159058073950681 0.788278847561868 0.53125 30.4 30 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0921728413117755 0.151632315822724 0.785551239092796 0.529411764705882 30.4 30 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0921728413117755 0.151632315822724 0.785551239092796 0.529411764705882 30.4 30 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0220786340330955 0.0450113126491331 0.784304332364077 0.528571428571429 30.4 30 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0412236408248 0.0761834297320655 0.782377294692421 0.527272727272727 30.4 30 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0412236408248 0.0761834297320655 0.782377294692421 0.527272727272727 30.4 30 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.180785387232585 0.252305063509619 0.777238527568005 0.523809523809524 30.4 30 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0142339661828819 0.0302764333008087 0.774883259302647 0.522222222222222 30.4 30 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0681370006876372 0.115564901047089 0.774166438526234 0.521739130434783 30.4 30 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00012611468048911 0.000509832927090919 0.768094544890734 0.517647058823529 30.4 30 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.134702993175197 0.208804312950223 0.7658420682195 0.516129032258065 30.4 30 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.127356258595807 0.198714864015168 0.764391609756963 0.515151515151515 30.4 30 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.114079431455149 0.178586392696014 0.761961111792712 0.513513513513513 30.4 30 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00240332628374159 0.00666653665061264 0.7591632129734 0.511627906976744 30.4 30 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0613181657598192 0.107193795916736 0.754071954466127 0.508196721311475 30.4 30 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0130401691742139 0.0283733344570433 0.747751310702504 0.503937007874016 30.4 30 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00611481139052717 0.0151927100966566 0.746517637150297 0.503105590062112 30.4 30 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00278428504727397 0.00759011038749207 0.745675541676918 0.50253807106599 30.4 30 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0540190080125061 0.0977977715035575 0.741909503587641 0.5 30.4 30 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00746138359394638 0.0181807343393591 0.741909503587641 0.5 30.4 30 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0350658744597624 0.0664430617260211 0.741909503587641 0.5 30.4 30 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0691751530617315 0.117186003341481 0.741909503587641 0.5 30.4 30 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.183017765216943 0.252358798356309 0.741909503587641 0.5 30.4 30 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.194539006731892 0.26772631197242 0.741909503587641 0.5 30.4 30 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.207065170054741 0.284689600954489 0.741909503587641 0.5 30.4 30 4 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.252292426808665 0.340295851515385 0.741909503587641 0.5 30.4 30 4 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.270688429367758 0.364417819290748 0.741909503587641 0.5 30.4 30 4 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.314725318414569 0.41276878166261 0.741909503587641 0.5 30.4 30 4 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.373432684409006 0.465319360695285 0.741909503587641 0.5 30.4 30 4 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.373432684409006 0.465319360695285 0.741909503587641 0.5 30.4 30 4 EICOSANOIDS%REACTOME DATABASE ID RELEASE 48%5604883 EICOSANOIDS 0.373432684409006 0.465319360695285 0.741909503587641 0.5 30.4 30 4 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.373432684409006 0.465319360695285 0.741909503587641 0.5 30.4 30 4 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.373432684409006 0.465319360695285 0.741909503587641 0.5 30.4 30 4 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.373432684409006 0.465319360695285 0.741909503587641 0.5 30.4 30 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.17238391453789 0.251334334413337 0.741909503587641 0.5 30.4 30 4 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.235740270814412 0.320399623083962 0.741909503587641 0.5 30.4 30 4 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.291318933154219 0.389611693494788 0.741909503587641 0.5 30.4 30 4 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.34169316014369 0.438044474670694 0.741909503587641 0.5 30.4 30 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0282045428481623 0.0555118457440318 0.729747052709155 0.491803278688525 30.4 30 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.136055295625367 0.210442049646627 0.726768493310342 0.489795918367347 30.4 30 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.136055295625367 0.210442049646627 0.726768493310342 0.489795918367347 30.4 30 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0242186192259475 0.0488145823775117 0.717976938955782 0.483870967741935 30.4 30 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.228312864006082 0.312093377022723 0.717976938955782 0.483870967741935 30.4 30 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.228312864006082 0.312093377022723 0.717976938955782 0.483870967741935 30.4 30 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.2590685207798 0.349104644952325 0.714431373825136 0.481481481481481 30.4 30 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.174589018004971 0.252305063509619 0.710996607604823 0.479166666666667 30.4 30 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.174589018004971 0.252305063509619 0.710996607604823 0.479166666666667 30.4 30 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.295934471925697 0.392099398091496 0.709652568649048 0.478260869565217 30.4 30 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.187261689276139 0.257960681355223 0.699914626026076 0.471698113207547 30.4 30 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.295538439385739 0.391939607871302 0.692448870015132 0.466666666666667 30.4 30 4 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.398262537422381 0.492189079612362 0.692448870015132 0.466666666666667 30.4 30 4 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.398262537422381 0.492189079612362 0.692448870015132 0.466666666666667 30.4 30 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0576713972325523 0.10335818420897 0.691841991075592 0.466257668711656 30.4 30 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0245316045104442 0.0493754925295078 0.691257047519408 0.465863453815261 30.4 30 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0628059357959915 0.109391489152627 0.690582431012395 0.465408805031447 30.4 30 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0628059357959915 0.109391489152627 0.690582431012395 0.465408805031447 30.4 30 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.180006218470702 0.252305063509619 0.688147945356652 0.463768115942029 30.4 30 4 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.433294951186529 0.526990355161052 0.684839541773207 0.461538461538462 30.4 30 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.104883190393333 0.164733752681803 0.679212925819671 0.457746478873239 30.4 30 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.273798282337987 0.366523947099676 0.677395633710455 0.456521739130435 30.4 30 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.330077813924526 0.423917625644946 0.674463185079674 0.454545454545455 30.4 30 4 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.474416124357375 0.570662844429877 0.674463185079674 0.454545454545455 30.4 30 4 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.474416124357375 0.570662844429877 0.674463185079674 0.454545454545455 30.4 30 4 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.474416124357375 0.570662844429877 0.674463185079674 0.454545454545455 30.4 30 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.134322385849893 0.208441390473716 0.671509331714361 0.452554744525547 30.4 30 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.134322385849893 0.208441390473716 0.671509331714361 0.452554744525547 30.4 30 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.144816207034971 0.223264856566375 0.667718553228877 0.45 30.4 30 4 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.413767770975567 0.503671118989077 0.667718553228877 0.45 30.4 30 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.157061102158948 0.23877985937199 0.665536466453619 0.448529411764706 30.4 30 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.334286691331688 0.428935943881869 0.659475114300125 0.444444444444444 30.4 30 4 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.44559727902776 0.541490117896244 0.659475114300125 0.444444444444444 30.4 30 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.23646301217162 0.321075254122343 0.657775436170486 0.443298969072165 30.4 30 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.145822530130907 0.224573009065238 0.657692749126341 0.443243243243243 30.4 30 4 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.407864143052814 0.498189421085111 0.649170815639186 0.4375 30.4 30 4 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.481440896297617 0.578623644790126 0.649170815639186 0.4375 30.4 30 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.369421909542521 0.462752972956873 0.64392145594399 0.433962264150943 30.4 30 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.29776151570272 0.394153150553461 0.642037070412382 0.432692307692308 30.4 30 4 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.522222175765498 0.618897662548045 0.635922431646549 0.428571428571429 30.4 30 4 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.522222175765498 0.618897662548045 0.635922431646549 0.428571428571429 30.4 30 4 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.522222175765498 0.618897662548045 0.635922431646549 0.428571428571429 30.4 30 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.399912514494016 0.492189079612362 0.632447445681268 0.426229508196721 30.4 30 4 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.521592488429431 0.618897662548045 0.624765897758013 0.421052631578947 30.4 30 4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.521592488429431 0.618897662548045 0.624765897758013 0.421052631578947 30.4 30 4 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.521421426138146 0.618897662548045 0.618257919656367 0.416666666666667 30.4 30 4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.569218241652864 0.665022625510695 0.618257919656367 0.416666666666667 30.4 30 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.121322468738962 0.189716343973124 0.615965841515202 0.415121951219512 30.4 30 4 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.60486193466091 0.703201415868035 0.593527602870113 0.4 30.4 30 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.594376285837905 0.691576005517039 0.588098996746301 0.396341463414634 30.4 30 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.607315923189696 0.705478007101173 0.584534760402384 0.393939393939394 30.4 30 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.638016118056993 0.726325502266642 0.582359072708578 0.39247311827957 30.4 30 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.660819594286671 0.745714736455141 0.568271109130959 0.382978723404255 30.4 30 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.771390218148122 0.851505189446286 0.543370340655737 0.366197183098592 30.4 30 4 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.735331297000351 0.819402063924432 0.534174842583102 0.36 30.4 30 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.838624344587394 0.908294893553141 0.525910534188707 0.354430379746835 30.4 30 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.79633232450998 0.866346252123626 0.525519231707912 0.354166666666667 30.4 30 4 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.743260217350601 0.827589428239362 0.523700826061864 0.352941176470588 30.4 30 4 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.757557297543546 0.842849127759551 0.519336652511349 0.35 30.4 30 4 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.77060706699266 0.851505189446286 0.516110959017489 0.347826086956522 30.4 30 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.973804770115621 1 0.506002795073598 0.341013824884793 30.4 30 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.997507847239425 1 0.497155852919553 0.335051546391753 30.4 30 4 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.806565466844012 0.876808754254415 0.494606335725094 0.333333333333333 30.4 30 4 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.883260722226593 0.944982005485259 0.483103862801255 0.325581395348837 30.4 30 4 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.868480466657549 0.935782804292438 0.480059090556709 0.323529411764706 30.4 30 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.998666152730331 1 0.471642470137857 0.317857142857143 30.4 30 4 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.8936916744836 0.95329153205532 0.466343116540803 0.314285714285714 30.4 30 4 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.838720653639373 0.908294893553141 0.463693439742276 0.3125 30.4 30 4 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.93026426449951 0.979753692269134 0.430786163373469 0.290322580645161 30.4 30 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.995339231082143 1 0.425911011318831 0.287037037037037 30.4 30 4 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.930084215067887 0.979753692269134 0.415469322009079 0.28 30.4 30 4 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.931145382898643 0.979753692269134 0.404677911047804 0.272727272727273 30.4 30 4 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.931145382898643 0.979753692269134 0.404677911047804 0.272727272727273 30.4 30 4 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.979980428095095 1 0.401867647776639 0.270833333333333 30.4 30 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999940657836427 1 0.396247121234308 0.267045454545455 30.4 30 4 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.975898615386103 1 0.38155345898793 0.257142857142857 30.4 30 4 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.951480681369991 0.999968249327546 0.37095475179382 0.25 30.4 30 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.984018519801248 1 0.346224435007566 0.233333333333333 30.4 30 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.343857301410897 0.231738035264484 30.4 30 4 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999908382967035 1 0.329737557150063 0.222222222222222 30.4 30 4 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.982165793008284 1 0.322569349385931 0.217391304347826 30.4 30 4 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.989651332119302 1 0.317961215823275 0.214285714285714 30.4 30 4 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.998251065694855 1 0.315706171739422 0.212765957446809 30.4 30 4 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.996416379869375 1 0.312382948879007 0.210526315789474 30.4 30 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.292470654217189 0.197106690777577 30.4 30 4 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.996335793569313 1 0.287190775582313 0.193548387096774 30.4 30 4 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.996335793569313 1 0.287190775582313 0.193548387096774 30.4 30 4 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0263258210950453 0.017741935483871 30.4 30 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 1.32709057784499e-06 5.53797622367571e-06 2.42079257840073 1 4.1 4 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.48729105209712e-13 1.67969457709064e-12 2.42079257840073 1 4.1 4 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 5.98169867905083e-12 5.56337073221525e-11 2.42079257840073 1 4.1 4 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 8.23431744404598e-10 5.85871686143871e-09 2.42079257840073 1 4.1 4 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 3.87643654767566e-07 1.74562316688053e-06 2.42079257840073 1 4.1 4 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 4.54294436832895e-06 1.75668745547068e-05 2.42079257840073 1 4.1 4 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 5.32252904750817e-05 0.000176138577548933 2.42079257840073 1 4.1 4 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 5.32252904750817e-05 0.000176138577548933 2.42079257840073 1 4.1 4 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 5.32252904750817e-05 0.000176138577548933 2.42079257840073 1 4.1 4 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 5.32252904750817e-05 0.000176138577548933 2.42079257840073 1 4.1 4 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 5.32252904750817e-05 0.000176138577548933 2.42079257840073 1 4.1 4 1 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00213332156457516 0.00538247621700436 2.42079257840073 1 4.1 4 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00213332156457516 0.00538247621700436 2.42079257840073 1 4.1 4 1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00213332156457516 0.00538247621700436 2.42079257840073 1 4.1 4 1 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00213332156457516 0.00538247621700436 2.42079257840073 1 4.1 4 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00213332156457516 0.00538247621700436 2.42079257840073 1 4.1 4 1 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.00213332156457516 0.00538247621700436 2.42079257840073 1 4.1 4 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00213332156457516 0.00538247621700436 2.42079257840073 1 4.1 4 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000182163690922639 0.000543435916526027 2.42079257840073 1 4.1 4 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.000182163690922639 0.000543435916526027 2.42079257840073 1 4.1 4 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.000182163690922639 0.000543435916526027 2.42079257840073 1 4.1 4 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 6.77597972561427e-15 1.0833954100617e-13 2.34009949245404 0.966666666666667 4.1 4 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 1.12212038211857e-07 5.41280441950755e-07 2.26949304225068 0.9375 4.1 4 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 1.12212038211857e-07 5.41280441950755e-07 2.26949304225068 0.9375 4.1 4 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 3.60817102789913e-07 1.62997694371443e-06 2.25940640650734 0.933333333333333 4.1 4 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 3.60817102789913e-07 1.62997694371443e-06 2.25940640650734 0.933333333333333 4.1 4 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 1.15523880369785e-06 4.84927674826561e-06 2.24787882280067 0.928571428571429 4.1 4 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 3.68069433417483e-06 1.44685857390353e-05 2.23457776467759 0.923076923076923 4.1 4 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.4986752039515e-19 3.55435802537163e-18 2.219059863534 0.916666666666667 4.1 4 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 1.16610067316966e-05 4.26417934980274e-05 2.219059863534 0.916666666666667 4.1 4 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 1.16610067316966e-05 4.26417934980274e-05 2.219059863534 0.916666666666667 4.1 4 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 2.4682304888322e-09 1.60378629479828e-08 2.20072052581884 0.909090909090909 4.1 4 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 3.67014822731685e-05 0.00012405275362166 2.20072052581884 0.909090909090909 4.1 4 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 2.3914976468425e-08 1.2374913278025e-07 2.17871332056065 0.9 4.1 4 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 2.3914976468425e-08 1.2374913278025e-07 2.17871332056065 0.9 4.1 4 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000114618101262226 0.000354568604556843 2.17871332056065 0.9 4.1 4 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.000114618101262226 0.000354568604556843 2.17871332056065 0.9 4.1 4 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000114618101262226 0.000354568604556843 2.17871332056065 0.9 4.1 4 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.21774628218092e-13 1.60449348105875e-12 2.15181562524509 0.888888888888889 4.1 4 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000354623933813986 0.00102775938455662 2.15181562524509 0.888888888888889 4.1 4 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000354623933813986 0.00102775938455662 2.15181562524509 0.888888888888889 4.1 4 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.000354623933813986 0.00102775938455662 2.15181562524509 0.888888888888889 4.1 4 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000354623933813986 0.00102775938455662 2.15181562524509 0.888888888888889 4.1 4 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000354623933813986 0.00102775938455662 2.15181562524509 0.888888888888889 4.1 4 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 3.71652257001568e-13 3.88868501259729e-12 2.14413056944064 0.885714285714286 4.1 4 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.50526474318338e-09 1.00093071474297e-08 2.13029746899264 0.88 4.1 4 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3.4244005643076e-12 3.31491292721749e-11 2.12736317495821 0.878787878787879 4.1 4 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 2.10105255483631e-06 8.37478371297497e-06 2.11819350610064 0.875 4.1 4 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 2.10105255483631e-06 8.37478371297497e-06 2.11819350610064 0.875 4.1 4 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00108473249405553 0.00292898356554274 2.11819350610064 0.875 4.1 4 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.00108473249405553 0.00292898356554274 2.11819350610064 0.875 4.1 4 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00108473249405553 0.00292898356554274 2.11819350610064 0.875 4.1 4 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00108473249405553 0.00292898356554274 2.11819350610064 0.875 4.1 4 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 6.31897985959939e-06 2.39146498409839e-05 2.09802023461396 0.866666666666667 4.1 4 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 6.31897985959939e-06 2.39146498409839e-05 2.09802023461396 0.866666666666667 4.1 4 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 1.21200102096755e-07 5.7489248427894e-07 2.07496506720062 0.857142857142857 4.1 4 1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.00327089601822145 0.0080947565807463 2.07496506720062 0.857142857142857 4.1 4 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00327089601822145 0.0080947565807463 2.07496506720062 0.857142857142857 4.1 4 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00327089601822145 0.0080947565807463 2.07496506720062 0.857142857142857 4.1 4 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.67304363627457e-11 1.4695932681597e-10 2.06479366981238 0.852941176470588 4.1 4 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 3.57082138014171e-07 1.62341176483759e-06 2.05767369164062 0.85 4.1 4 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 7.05861701636008e-09 3.89318295127147e-08 2.04836295095446 0.846153846153846 4.1 4 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 7.05861701636008e-09 3.89318295127147e-08 2.04836295095446 0.846153846153846 4.1 4 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 5.55527249180664e-05 0.000182989647125945 2.04836295095446 0.846153846153846 4.1 4 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 5.55527249180664e-05 0.000182989647125945 2.04836295095446 0.846153846153846 4.1 4 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 8.50462047571021e-12 7.80779028189395e-11 2.02823161974115 0.837837837837838 4.1 4 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 3.47755457061491e-20 9.16400028515743e-19 2.02334902075285 0.835820895522388 4.1 4 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.35133393740226e-25 1.58964939764114e-23 2.02207380078178 0.835294117647059 4.1 4 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.35133393740226e-25 1.58964939764114e-23 2.02207380078178 0.835294117647059 4.1 4 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.35133393740226e-25 1.58964939764114e-23 2.02207380078178 0.835294117647059 4.1 4 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 1.19457489366093e-09 8.05630366672749e-09 2.01732714866727 0.833333333333333 4.1 4 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 5.92830506050268e-08 2.92915906288032e-07 2.01732714866727 0.833333333333333 4.1 4 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 3.02332383956703e-06 1.19174233343598e-05 2.01732714866727 0.833333333333333 4.1 4 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 3.02332383956703e-06 1.19174233343598e-05 2.01732714866727 0.833333333333333 4.1 4 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.000161903859980528 0.000491234952563522 2.01732714866727 0.833333333333333 4.1 4 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000161903859980528 0.000491234952563522 2.01732714866727 0.833333333333333 4.1 4 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000161903859980528 0.000491234952563522 2.01732714866727 0.833333333333333 4.1 4 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.000161903859980528 0.000491234952563522 2.01732714866727 0.833333333333333 4.1 4 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.000161903859980528 0.000491234952563522 2.01732714866727 0.833333333333333 4.1 4 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00968287355619577 0.0210041601683942 2.01732714866727 0.833333333333333 4.1 4 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 3.04034675270955e-14 4.16001291260163e-13 2.00874277782188 0.829787234042553 4.1 4 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 7.01317839675447e-11 5.80218189452419e-10 2.0057995649606 0.828571428571429 4.1 4 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.69893120683365e-07 8.0052288321996e-07 1.99978517346147 0.826086956521739 4.1 4 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 8.67167140999317e-06 3.238789610609e-05 1.99359388809472 0.823529411764706 4.1 4 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 8.67167140999317e-06 3.238789610609e-05 1.99359388809472 0.823529411764706 4.1 4 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 8.67167140999317e-06 3.238789610609e-05 1.99359388809472 0.823529411764706 4.1 4 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 8.67167140999317e-06 3.238789610609e-05 1.99359388809472 0.823529411764706 4.1 4 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 6.6048220153725e-30 4.47555320375003e-28 1.99093221401181 0.822429906542056 4.1 4 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 4.82819097961655e-07 2.14034759002939e-06 1.98064847323696 0.818181818181818 4.1 4 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 4.82819097961655e-07 2.14034759002939e-06 1.98064847323696 0.818181818181818 4.1 4 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000465242886712984 0.0013194650254342 1.98064847323696 0.818181818181818 4.1 4 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.000465242886712984 0.0013194650254342 1.98064847323696 0.818181818181818 4.1 4 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000465242886712984 0.0013194650254342 1.98064847323696 0.818181818181818 4.1 4 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000465242886712984 0.0013194650254342 1.98064847323696 0.818181818181818 4.1 4 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.000465242886712984 0.0013194650254342 1.98064847323696 0.818181818181818 4.1 4 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000465242886712984 0.0013194650254342 1.98064847323696 0.818181818181818 4.1 4 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.000465242886712984 0.0013194650254342 1.98064847323696 0.818181818181818 4.1 4 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.46001268027958e-27 1.52199914958167e-25 1.98064847323696 0.818181818181818 4.1 4 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 2.45966648469063e-05 8.62094928008562e-05 1.96689396995059 0.8125 4.1 4 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 2.45966648469063e-05 8.62094928008562e-05 1.96689396995059 0.8125 4.1 4 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 2.45966648469063e-05 8.62094928008562e-05 1.96689396995059 0.8125 4.1 4 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 2.45966648469063e-05 8.62094928008562e-05 1.96689396995059 0.8125 4.1 4 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 2.45966648469063e-05 8.62094928008562e-05 1.96689396995059 0.8125 4.1 4 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 5.47661529458553e-12 5.1271207659179e-11 1.95968923013392 0.80952380952381 4.1 4 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 1.35958079066319e-06 5.64047657467555e-06 1.95968923013392 0.80952380952381 4.1 4 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.35958079066319e-06 5.64047657467555e-06 1.95968923013392 0.80952380952381 4.1 4 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.93072889181231e-14 2.83239918871023e-13 1.95525554409289 0.807692307692308 4.1 4 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.93072889181231e-14 2.83239918871023e-13 1.95525554409289 0.807692307692308 4.1 4 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.18581916363178e-24 5.27318959327507e-23 1.95225207935542 0.806451612903226 4.1 4 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 4.44524594326633e-09 2.77416534685141e-08 1.95225207935542 0.806451612903226 4.1 4 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 4.44524594326633e-09 2.77416534685141e-08 1.95225207935542 0.806451612903226 4.1 4 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.52432625349125e-11 1.34727717932798e-10 1.94844280700546 0.804878048780488 4.1 4 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.52432625349125e-11 1.34727717932798e-10 1.94844280700546 0.804878048780488 4.1 4 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.14707334107868e-19 2.76658536331349e-18 1.93663406272058 0.8 4.1 4 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.14707334107868e-19 2.76658536331349e-18 1.93663406272058 0.8 4.1 4 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.14707334107868e-19 2.76658536331349e-18 1.93663406272058 0.8 4.1 4 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.14707334107868e-19 2.76658536331349e-18 1.93663406272058 0.8 4.1 4 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.14707334107868e-19 2.76658536331349e-18 1.93663406272058 0.8 4.1 4 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 3.78993885141811e-06 1.48161620482637e-05 1.93663406272058 0.8 4.1 4 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 3.78993885141811e-06 1.48161620482637e-05 1.93663406272058 0.8 4.1 4 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00131464726402103 0.0034713677920947 1.93663406272058 0.8 4.1 4 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00131464726402103 0.0034713677920947 1.93663406272058 0.8 4.1 4 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00131464726402103 0.0034713677920947 1.93663406272058 0.8 4.1 4 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00131464726402103 0.0034713677920947 1.93663406272058 0.8 4.1 4 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.28912021194443e-16 9.06797356818906e-15 1.93663406272058 0.8 4.1 4 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.28912021194443e-16 9.06797356818906e-15 1.93663406272058 0.8 4.1 4 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.28912021194443e-16 9.06797356818906e-15 1.93663406272058 0.8 4.1 4 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.28912021194443e-16 9.06797356818906e-15 1.93663406272058 0.8 4.1 4 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.28912021194443e-16 9.06797356818906e-15 1.93663406272058 0.8 4.1 4 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.28912021194443e-16 9.06797356818906e-15 1.93663406272058 0.8 4.1 4 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.28912021194443e-16 9.06797356818906e-15 1.93663406272058 0.8 4.1 4 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.48212623129902e-13 1.67969457709064e-12 1.93663406272058 0.8 4.1 4 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.23315651448815e-08 6.62181781176089e-08 1.93663406272058 0.8 4.1 4 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 2.14301595544552e-07 9.90101202791873e-07 1.93663406272058 0.8 4.1 4 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 2.14301595544552e-07 9.90101202791873e-07 1.93663406272058 0.8 4.1 4 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 6.88912181467859e-05 0.000220793250952424 1.93663406272058 0.8 4.1 4 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 6.88912181467859e-05 0.000220793250952424 1.93663406272058 0.8 4.1 4 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 6.88912181467859e-05 0.000220793250952424 1.93663406272058 0.8 4.1 4 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 6.88912181467859e-05 0.000220793250952424 1.93663406272058 0.8 4.1 4 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 6.88912181467859e-05 0.000220793250952424 1.93663406272058 0.8 4.1 4 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 6.88912181467859e-05 0.000220793250952424 1.93663406272058 0.8 4.1 4 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.90242918520275e-20 5.63990985529899e-19 1.9305054739145 0.79746835443038 4.1 4 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.90242918520275e-20 5.63990985529899e-19 1.9305054739145 0.79746835443038 4.1 4 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.90242918520275e-20 5.63990985529899e-19 1.9305054739145 0.79746835443038 4.1 4 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.43201225657609e-14 3.35995479719202e-13 1.92766816428206 0.796296296296296 4.1 4 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 4.07723388544874e-13 4.20427812970548e-12 1.92675327668629 0.795918367346939 4.1 4 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 8.65847520856204e-19 1.92515784715372e-17 1.92336944585263 0.794520547945205 4.1 4 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 1.97623586326026e-09 1.29593715825776e-08 1.92239410637705 0.794117647058823 4.1 4 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 3.3944575294026e-08 1.71287697317018e-07 1.91993894149023 0.793103448275862 4.1 4 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 5.9021138698105e-07 2.56841224365148e-06 1.91646079123391 0.791666666666667 4.1 4 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.35079230913617e-20 6.61002735300562e-19 1.91272500021786 0.790123456790123 4.1 4 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.35079230913617e-20 6.61002735300562e-19 1.91272500021786 0.790123456790123 4.1 4 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 5.10543024161103e-11 4.29883268272929e-10 1.90205131160057 0.785714285714286 4.1 4 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000190190148721842 0.000566193685420881 1.90205131160057 0.785714285714286 4.1 4 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.82981989934997e-31 2.7249168583875e-29 1.89939109997595 0.784615384615385 4.1 4 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.46395129082484e-08 7.77314435389456e-08 1.89124420187557 0.78125 4.1 4 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.23990504240759e-24 5.34662083438181e-23 1.88542498894672 0.778846153846154 4.1 4 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.32444216584421e-09 1.51728495504418e-08 1.88283867208945 0.777777777777778 4.1 4 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.50684010148403e-07 1.14702040656327e-06 1.88283867208945 0.777777777777778 4.1 4 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 2.84408879064848e-05 9.87041976758808e-05 1.88283867208945 0.777777777777778 4.1 4 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00364011245490096 0.00876460240833175 1.88283867208945 0.777777777777778 4.1 4 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00364011245490096 0.00876460240833175 1.88283867208945 0.777777777777778 4.1 4 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00364011245490096 0.00876460240833175 1.88283867208945 0.777777777777778 4.1 4 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00364011245490096 0.00876460240833175 1.88283867208945 0.777777777777778 4.1 4 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00364011245490096 0.00876460240833175 1.88283867208945 0.777777777777778 4.1 4 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.00364011245490096 0.00876460240833175 1.88283867208945 0.777777777777778 4.1 4 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00364011245490096 0.00876460240833175 1.88283867208945 0.777777777777778 4.1 4 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.34993897270466e-20 8.99427010973346e-19 1.87967423734645 0.776470588235294 4.1 4 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.70557537887587e-10 2.71805864130947e-09 1.87611424826056 0.775 4.1 4 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.70557537887587e-10 2.71805864130947e-09 1.87611424826056 0.775 4.1 4 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 4.34057054584841e-06 1.68760434063997e-05 1.87061244694602 0.772727272727273 4.1 4 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 6.22221538674486e-09 3.49968873333515e-08 1.86746856048056 0.771428571428571 4.1 4 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 6.22221538674486e-09 3.49968873333515e-08 1.86746856048056 0.771428571428571 4.1 4 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 6.7408310180326e-65 1.91844050773208e-62 1.86723250074595 0.771331058020478 4.1 4 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 6.30852887970516e-25 2.89581825671627e-23 1.86556492280423 0.770642201834862 4.1 4 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.44471611861978e-38 5.74984639708722e-36 1.86543428100291 0.770588235294118 4.1 4 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.20998736326466e-57 2.45973145417945e-55 1.86428853738906 0.770114942528736 4.1 4 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 6.71635036506237e-07 2.88742192431533e-06 1.86214813723133 0.769230769230769 4.1 4 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000516407643522067 0.00144087858182726 1.86214813723133 0.769230769230769 4.1 4 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.000516407643522067 0.00144087858182726 1.86214813723133 0.769230769230769 4.1 4 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000516407643522067 0.00144087858182726 1.86214813723133 0.769230769230769 4.1 4 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000516407643522067 0.00144087858182726 1.86214813723133 0.769230769230769 4.1 4 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000516407643522067 0.00144087858182726 1.86214813723133 0.769230769230769 4.1 4 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.18252662561496e-37 1.29441183711546e-35 1.86214813723133 0.769230769230769 4.1 4 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.67237913442348e-22 6.26261975864372e-21 1.85838622180258 0.767676767676768 4.1 4 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.57584377597322e-10 1.21212199632967e-09 1.857817560168 0.767441860465116 4.1 4 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.32139756200046e-91 6.26782910242218e-89 1.85253140976206 0.765258215962441 4.1 4 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 4.04354851095005e-12 3.88781725073103e-11 1.85119432465938 0.764705882352941 4.1 4 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.65244358481852e-08 8.70898970813615e-08 1.85119432465938 0.764705882352941 4.1 4 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 7.63528935168732e-05 0.000241444816610024 1.85119432465938 0.764705882352941 4.1 4 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 1.15670846458338e-05 4.26417934980274e-05 1.84441339306722 0.761904761904762 4.1 4 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.15670846458338e-05 4.26417934980274e-05 1.84441339306722 0.761904761904762 4.1 4 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 6.64455404277496e-11 5.52935696074197e-10 1.84190739660925 0.760869565217391 4.1 4 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.03328274490666e-35 3.37609490941305e-33 1.84158453816988 0.760736196319018 4.1 4 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.74738831481796e-13 2.96176785756512e-12 1.83646333533848 0.758620689655172 4.1 4 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.74738831481796e-13 2.96176785756512e-12 1.83646333533848 0.758620689655172 4.1 4 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 6.874604719516e-09 3.82131348276221e-08 1.83195114041136 0.756756756756757 4.1 4 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 6.874604719516e-09 3.82131348276221e-08 1.83195114041136 0.756756756756757 4.1 4 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.4739807223834e-25 7.76842432574656e-24 1.8308515298829 0.756302521008403 4.1 4 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.39594990421246e-26 1.36377468547773e-24 1.83035536415665 0.75609756097561 4.1 4 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.09150625386699e-09 7.43164305862549e-09 1.83035536415665 0.75609756097561 4.1 4 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.09150625386699e-09 7.43164305862549e-09 1.83035536415665 0.75609756097561 4.1 4 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.09150625386699e-09 7.43164305862549e-09 1.83035536415665 0.75609756097561 4.1 4 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.09150625386699e-09 7.43164305862549e-09 1.83035536415665 0.75609756097561 4.1 4 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 1.09150625386699e-09 7.43164305862549e-09 1.83035536415665 0.75609756097561 4.1 4 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.09150625386699e-09 7.43164305862549e-09 1.83035536415665 0.75609756097561 4.1 4 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.89466450326404e-27 2.30921149506031e-25 1.82989045296433 0.755905511811024 4.1 4 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.84134000903617e-09 1.82127334813445e-08 1.81559443380054 0.75 4.1 4 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 4.66677630371085e-06 1.78997915907831e-05 1.81559443380054 0.75 4.1 4 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 4.66677630371085e-06 1.78997915907831e-05 1.81559443380054 0.75 4.1 4 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 3.04185341870949e-05 0.000103802336086897 1.81559443380054 0.75 4.1 4 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 3.04185341870949e-05 0.000103802336086897 1.81559443380054 0.75 4.1 4 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 3.04185341870949e-05 0.000103802336086897 1.81559443380054 0.75 4.1 4 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 3.04185341870949e-05 0.000103802336086897 1.81559443380054 0.75 4.1 4 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000201774878046426 0.000594463046501169 1.81559443380054 0.75 4.1 4 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000201774878046426 0.000594463046501169 1.81559443380054 0.75 4.1 4 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000201774878046426 0.000594463046501169 1.81559443380054 0.75 4.1 4 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00137525996691035 0.00355171494176666 1.81559443380054 0.75 4.1 4 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00137525996691035 0.00355171494176666 1.81559443380054 0.75 4.1 4 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00137525996691035 0.00355171494176666 1.81559443380054 0.75 4.1 4 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00137525996691035 0.00355171494176666 1.81559443380054 0.75 4.1 4 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00982938659071917 0.0210334092008923 1.81559443380054 0.75 4.1 4 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 7.24750877896142e-07 3.08778592588686e-06 1.81559443380054 0.75 4.1 4 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 7.24750877896142e-07 3.08778592588686e-06 1.81559443380054 0.75 4.1 4 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.89646847468852e-105 1.34933731974088e-102 1.81329330017089 0.749049429657795 4.1 4 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.01344155180008e-14 2.89406800829446e-13 1.80656162567218 0.746268656716418 4.1 4 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.86718027448495e-10 1.42849329601725e-09 1.80271787753246 0.74468085106383 4.1 4 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.96090243130694e-22 2.47634103993745e-20 1.79317968770424 0.740740740740741 4.1 4 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 4.78728381193584e-10 3.42326877607271e-09 1.78928147099184 0.739130434782609 4.1 4 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.20790213466223e-05 4.35488149892132e-05 1.78928147099184 0.739130434782609 4.1 4 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.77601868279122e-21 5.74380587639069e-20 1.7873141466697 0.738317757009346 4.1 4 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.32075736541391e-16 4.40325030797866e-15 1.78533452657054 0.7375 4.1 4 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 7.88235285256976e-05 0.000247061412097065 1.78374189987422 0.736842105263158 4.1 4 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.49809851308265e-26 1.91453622466024e-24 1.78374189987422 0.736842105263158 4.1 4 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.21851140774064e-09 8.1789704396931e-09 1.7752478908272 0.733333333333333 4.1 4 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.000523762207803246 0.00145853937711158 1.7752478908272 0.733333333333333 4.1 4 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 7.61361388677029e-09 4.15102396968357e-08 1.77131164273224 0.731707317073171 4.1 4 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 7.61361388677029e-09 4.15102396968357e-08 1.77131164273224 0.731707317073171 4.1 4 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 7.96750415507714e-11 6.51595311073263e-10 1.76904073036976 0.730769230769231 4.1 4 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 4.79061950421339e-06 1.82274105735178e-05 1.76904073036976 0.730769230769231 4.1 4 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 5.63240722181772e-14 7.63325283490154e-13 1.76372030712053 0.728571428571429 4.1 4 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.07634272893323e-17 8.05643847676664e-16 1.76057642065507 0.727272727272727 4.1 4 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.07785519948078e-09 1.95526247717015e-08 1.76057642065507 0.727272727272727 4.1 4 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 3.08377889124617e-05 0.000104730724635878 1.76057642065507 0.727272727272727 4.1 4 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 3.08377889124617e-05 0.000104730724635878 1.76057642065507 0.727272727272727 4.1 4 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00357972560350916 0.00872251632498892 1.76057642065507 0.727272727272727 4.1 4 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00357972560350916 0.00872251632498892 1.76057642065507 0.727272727272727 4.1 4 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00357972560350916 0.00872251632498892 1.76057642065507 0.727272727272727 4.1 4 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00357972560350916 0.00872251632498892 1.76057642065507 0.727272727272727 4.1 4 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00357972560350916 0.00872251632498892 1.76057642065507 0.727272727272727 4.1 4 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00357972560350916 0.00872251632498892 1.76057642065507 0.727272727272727 4.1 4 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00357972560350916 0.00872251632498892 1.76057642065507 0.727272727272727 4.1 4 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.72612357984961e-18 5.78996097630746e-17 1.75825987273316 0.726315789473684 4.1 4 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.00499590967823e-10 1.50163641024848e-09 1.75626128236915 0.725490196078431 4.1 4 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.00499590967823e-10 1.50163641024848e-09 1.75626128236915 0.725490196078431 4.1 4 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.00499590967823e-10 1.50163641024848e-09 1.75626128236915 0.725490196078431 4.1 4 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.41277558762038e-13 1.62127392030951e-12 1.75419752058024 0.72463768115942 4.1 4 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.02079687120671e-16 1.96296479422588e-15 1.75298772918673 0.724137931034483 4.1 4 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 1.89956846377086e-06 7.70109949842148e-06 1.75298772918673 0.724137931034483 4.1 4 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.89956846377086e-06 7.70109949842148e-06 1.75298772918673 0.724137931034483 4.1 4 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 1.89956846377086e-06 7.70109949842148e-06 1.75298772918673 0.724137931034483 4.1 4 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.20050670723885e-07 5.71344830903305e-07 1.74835019551164 0.722222222222222 4.1 4 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000200924108103883 0.000594463046501169 1.74835019551164 0.722222222222222 4.1 4 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000200924108103883 0.000594463046501169 1.74835019551164 0.722222222222222 4.1 4 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.86199674963203e-19 4.27358286246189e-18 1.74576387865437 0.721153846153846 4.1 4 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 7.71210879329793e-09 4.17274935850303e-08 1.74522255652145 0.720930232558139 4.1 4 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.13523179723044e-18 2.44762855675593e-17 1.74297065644852 0.72 4.1 4 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.13523179723044e-18 2.44762855675593e-17 1.74297065644852 0.72 4.1 4 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 1.20883920736045e-05 4.35488149892132e-05 1.74297065644852 0.72 4.1 4 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 1.20883920736045e-05 4.35488149892132e-05 1.74297065644852 0.72 4.1 4 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 1.20883920736045e-05 4.35488149892132e-05 1.74297065644852 0.72 4.1 4 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.09501610948151e-20 8.46963062267729e-19 1.73856921539689 0.718181818181818 4.1 4 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 3.09642216743703e-09 1.95831499745017e-08 1.73665554537443 0.717391304347826 4.1 4 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 6.9537651499298e-18 1.41360111547859e-16 1.72913755600052 0.714285714285714 4.1 4 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.24263696373829e-09 8.30174835398864e-09 1.72913755600052 0.714285714285714 4.1 4 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 7.75471580402471e-05 0.000243597363998392 1.72913755600052 0.714285714285714 4.1 4 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 7.75471580402471e-05 0.000243597363998392 1.72913755600052 0.714285714285714 4.1 4 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 7.75471580402471e-05 0.000243597363998392 1.72913755600052 0.714285714285714 4.1 4 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 5.34874536827982e-12 5.04057262189549e-11 1.72913755600052 0.714285714285714 4.1 4 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 4.74835569660988e-06 1.81150406334473e-05 1.72913755600052 0.714285714285714 4.1 4 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 4.74835569660988e-06 1.81150406334473e-05 1.72913755600052 0.714285714285714 4.1 4 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.00133195138052263 0.0034713677920947 1.72913755600052 0.714285714285714 4.1 4 1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0257128174011316 0.0503985387903724 1.72913755600052 0.714285714285714 4.1 4 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 7.65470145607183e-09 4.15749624885123e-08 1.72145250019607 0.711111111111111 4.1 4 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 1.18733232834078e-07 5.66971108466085e-07 1.72003683202157 0.710526315789474 4.1 4 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 8.69920720228995e-13 8.65662367053049e-12 1.71911357016863 0.710144927536232 4.1 4 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 8.43529721883386e-22 2.79149487032572e-20 1.71798182983277 0.709677419354839 4.1 4 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 8.43529721883386e-22 2.79149487032572e-20 1.71798182983277 0.709677419354839 4.1 4 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 8.43529721883386e-22 2.79149487032572e-20 1.71798182983277 0.709677419354839 4.1 4 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.83204246871918e-36 6.10365445689381e-34 1.71760997229385 0.70952380952381 4.1 4 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.55257067143272e-15 2.53943455798709e-14 1.71707380560982 0.709302325581395 4.1 4 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.33021636470683e-14 3.2508802813508e-13 1.71600486570178 0.708860759493671 4.1 4 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 3.05838715230375e-09 1.95160758642522e-08 1.71472807636718 0.708333333333333 4.1 4 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 3.00801878794073e-05 0.000103641906422268 1.71472807636718 0.708333333333333 4.1 4 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 3.00801878794073e-05 0.000103641906422268 1.71472807636718 0.708333333333333 4.1 4 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 9.40267817685168e-15 1.45434902670217e-13 1.71226792130783 0.707317073170732 4.1 4 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 7.36841564694714e-07 3.120611745716e-06 1.70879476122404 0.705882352941177 4.1 4 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 7.36841564694714e-07 3.120611745716e-06 1.70879476122404 0.705882352941177 4.1 4 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000502787640917353 0.00141676596638692 1.70879476122404 0.705882352941177 4.1 4 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000502787640917353 0.00141676596638692 1.70879476122404 0.705882352941177 4.1 4 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000502787640917353 0.00141676596638692 1.70879476122404 0.705882352941177 4.1 4 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.85420815772594e-19 4.27358286246189e-18 1.70752333655051 0.705357142857143 4.1 4 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.21633722384205e-11 2.72431420805192e-10 1.70646034215133 0.704918032786885 4.1 4 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.21633722384205e-11 2.72431420805192e-10 1.70646034215133 0.704918032786885 4.1 4 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.21633722384205e-11 2.72431420805192e-10 1.70646034215133 0.704918032786885 4.1 4 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 8.5527095239458e-13 8.57077862857385e-12 1.704783505916 0.704225352112676 4.1 4 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.40347250567881e-37 4.4758152682721e-35 1.70432481977091 0.704035874439462 4.1 4 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 1.17167542218754e-05 4.26417934980274e-05 1.70352070331903 0.703703703703704 4.1 4 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 1.17167542218754e-05 4.26417934980274e-05 1.70352070331903 0.703703703703704 4.1 4 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 1.17167542218754e-05 4.26417934980274e-05 1.70352070331903 0.703703703703704 4.1 4 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 1.17167542218754e-05 4.26417934980274e-05 1.70352070331903 0.703703703703704 4.1 4 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 1.17167542218754e-05 4.26417934980274e-05 1.70352070331903 0.703703703703704 4.1 4 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 9.22039517482078e-15 1.44182663008461e-13 1.70031859673384 0.702380952380952 4.1 4 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 9.22039517482078e-15 1.44182663008461e-13 1.70031859673384 0.702380952380952 4.1 4 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 7.46650468060429e-09 4.10225334382236e-08 1.69970542738774 0.702127659574468 4.1 4 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.49327318872235e-15 2.4708462180836e-14 1.69455480488051 0.7 4.1 4 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.15094032385511e-07 5.51443798264585e-07 1.69455480488051 0.7 4.1 4 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00906619790028745 0.0200018598637349 1.69455480488051 0.7 4.1 4 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 4.5798686393419e-06 1.76616614465678e-05 1.69455480488051 0.7 4.1 4 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.32013872480931e-13 8.39684922369053e-12 1.69123865066352 0.698630136986301 4.1 4 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.12420118635086e-11 2.71081602937638e-10 1.69071227697828 0.698412698412698 4.1 4 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 3.33704784450515e-13 3.51749561683765e-12 1.68818429809524 0.697368421052632 4.1 4 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.33704784450515e-13 3.51749561683765e-12 1.68818429809524 0.697368421052632 4.1 4 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 7.37149719200943e-05 0.000233622282944976 1.68402961975703 0.695652173913043 4.1 4 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 7.37149719200943e-05 0.000233622282944976 1.68402961975703 0.695652173913043 4.1 4 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.00226784813603e-12 1.95152544376546e-11 1.68110595722273 0.694444444444444 4.1 4 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 7.05687899340828e-07 3.02468036374096e-06 1.68110595722273 0.694444444444444 4.1 4 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 8.01619225504198e-13 8.1478868420891e-12 1.67841618769117 0.693333333333333 4.1 4 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 2.85083803547344e-05 9.87041976758808e-05 1.6759333235082 0.692307692307692 4.1 4 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 2.85083803547344e-05 9.87041976758808e-05 1.6759333235082 0.692307692307692 4.1 4 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 2.85083803547344e-05 9.87041976758808e-05 1.6759333235082 0.692307692307692 4.1 4 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00330767769453398 0.00817157180437821 1.6759333235082 0.692307692307692 4.1 4 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.13351134164453e-09 7.68088875790553e-09 1.67254759962232 0.690909090909091 4.1 4 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 7.31542168116671e-33 5.7832472512779e-31 1.67149963746717 0.69047619047619 4.1 4 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 4.7901398125016e-12 4.54424596879318e-11 1.67068783579768 0.690140845070423 4.1 4 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.06310420137283e-14 2.90672997876588e-13 1.66951212303498 0.689655172413793 4.1 4 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.06310420137283e-14 2.90672997876588e-13 1.66951212303498 0.689655172413793 4.1 4 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 4.51112896162988e-10 3.25854645299458e-09 1.66951212303498 0.689655172413793 4.1 4 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.9146656037619e-12 1.87901320976082e-11 1.6683840743032 0.689189189189189 4.1 4 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.9146656037619e-12 1.87901320976082e-11 1.6683840743032 0.689189189189189 4.1 4 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 7.15976094156365e-11 5.88921376869658e-10 1.6642948976505 0.6875 4.1 4 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00123213433326825 0.00330193438086764 1.6642948976505 0.6875 4.1 4 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00123213433326825 0.00330193438086764 1.6642948976505 0.6875 4.1 4 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.6921423324622e-06 6.93924651035651e-06 1.6599720537605 0.685714285714286 4.1 4 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 1.6921423324622e-06 6.93924651035651e-06 1.6599720537605 0.685714285714286 4.1 4 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.37452264551347e-17 2.75485313319109e-16 1.65747960322933 0.684684684684685 4.1 4 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 6.64243970229243e-07 2.86430051404913e-06 1.65633176416892 0.684210526315789 4.1 4 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 6.64243970229243e-07 2.86430051404913e-06 1.65633176416892 0.684210526315789 4.1 4 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000465475363856619 0.0013194650254342 1.65633176416892 0.684210526315789 4.1 4 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000465475363856619 0.0013194650254342 1.65633176416892 0.684210526315789 4.1 4 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000465475363856619 0.0013194650254342 1.65633176416892 0.684210526315789 4.1 4 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 5.511199171318e-18 1.13658498851964e-16 1.65633176416892 0.684210526315789 4.1 4 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.61154100881847e-24 1.0617779587282e-22 1.64916494403549 0.68125 4.1 4 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.07295192148456e-11 9.66335812830716e-11 1.64748383807827 0.680555555555556 4.1 4 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.07295192148456e-11 9.66335812830716e-11 1.64748383807827 0.680555555555556 4.1 4 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 6.83127539667386e-05 0.000220793250952424 1.64613895331249 0.68 4.1 4 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 6.83127539667386e-05 0.000220793250952424 1.64613895331249 0.68 4.1 4 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 6.83127539667386e-05 0.000220793250952424 1.64613895331249 0.68 4.1 4 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 6.37798035826536e-09 3.57317561016205e-08 1.64431194004578 0.679245283018868 4.1 4 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.52947381750746e-09 1.63610965559687e-08 1.64268067820049 0.678571428571429 4.1 4 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.00424234977528e-09 7.03959046172522e-09 1.64121530739032 0.677966101694915 4.1 4 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.00424234977528e-09 7.03959046172522e-09 1.64121530739032 0.677966101694915 4.1 4 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 3.99078086524784e-10 2.91224675448599e-09 1.63989174665856 0.67741935483871 4.1 4 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.30964343191277e-24 9.66653706944669e-23 1.63846326952732 0.676829268292683 4.1 4 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 4.0090411826086e-06 1.56297687749371e-05 1.63759497950637 0.676470588235294 4.1 4 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.19130856565862e-126 1.16562320889322e-122 1.63485652636339 0.675339366515837 4.1 4 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.62252576407635e-14 2.45622783221345e-13 1.63084973702786 0.673684210526316 4.1 4 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.62252576407635e-14 2.45622783221345e-13 1.63084973702786 0.673684210526316 4.1 4 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 5.91892157393211e-09 3.35562764928502e-08 1.62853318910594 0.672727272727273 4.1 4 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 5.91892157393211e-09 3.35562764928502e-08 1.62853318910594 0.672727272727273 4.1 4 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 5.91892157393211e-09 3.35562764928502e-08 1.62853318910594 0.672727272727273 4.1 4 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 9.32003340966239e-10 6.5982127074376e-09 1.62709009367918 0.672131147540984 4.1 4 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.4730911484706e-10 1.14546923730801e-09 1.62590546310497 0.671641791044776 4.1 4 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.4730911484706e-10 1.14546923730801e-09 1.62590546310497 0.671641791044776 4.1 4 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.4730911484706e-10 1.14546923730801e-09 1.62590546310497 0.671641791044776 4.1 4 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 5.86333606190504e-11 4.90795718593581e-10 1.62538930264049 0.671428571428571 4.1 4 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.33535953922485e-11 2.03878320510243e-10 1.62491556632378 0.671232876712329 4.1 4 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 5.64705880770648e-07 2.46495849183016e-06 1.61386171893382 0.666666666666667 4.1 4 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 3.410840061476e-10 2.52792989972935e-09 1.61386171893382 0.666666666666667 4.1 4 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.37346498758281e-08 7.32000253681773e-08 1.61386171893382 0.666666666666667 4.1 4 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.22430209382181e-07 1.02433070534254e-06 1.61386171893382 0.666666666666667 4.1 4 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 2.40772446967392e-05 8.54411950210969e-05 1.61386171893382 0.666666666666667 4.1 4 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 6.20916326204529e-05 0.000203118145330815 1.61386171893382 0.666666666666667 4.1 4 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 6.20916326204529e-05 0.000203118145330815 1.61386171893382 0.666666666666667 4.1 4 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000160984540001469 0.000491234952563522 1.61386171893382 0.666666666666667 4.1 4 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00110651470654429 0.00297650364350194 1.61386171893382 0.666666666666667 4.1 4 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00110651470654429 0.00297650364350194 1.61386171893382 0.666666666666667 4.1 4 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0029483297259614 0.00734758879166913 1.61386171893382 0.666666666666667 4.1 4 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00798865687670679 0.0179021397410295 1.61386171893382 0.666666666666667 4.1 4 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00798865687670679 0.0179021397410295 1.61386171893382 0.666666666666667 4.1 4 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.00798865687670679 0.0179021397410295 1.61386171893382 0.666666666666667 4.1 4 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00798865687670679 0.0179021397410295 1.61386171893382 0.666666666666667 4.1 4 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0222079348623556 0.0448890501550171 1.61386171893382 0.666666666666667 4.1 4 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0222079348623556 0.0448890501550171 1.61386171893382 0.666666666666667 4.1 4 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0222079348623556 0.0448890501550171 1.61386171893382 0.666666666666667 4.1 4 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0222079348623556 0.0448890501550171 1.61386171893382 0.666666666666667 4.1 4 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0222079348623556 0.0448890501550171 1.61386171893382 0.666666666666667 4.1 4 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0222079348623556 0.0448890501550171 1.61386171893382 0.666666666666667 4.1 4 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0222079348623556 0.0448890501550171 1.61386171893382 0.666666666666667 4.1 4 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.97247645678049e-09 1.29593715825776e-08 1.60084670507145 0.661290322580645 4.1 4 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.96678380888555e-09 2.84989248388877e-08 1.60018492470556 0.661016949152542 4.1 4 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 3.15932964106196e-08 1.59990251929935e-07 1.59863660837784 0.660377358490566 4.1 4 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.7713939932037e-29 1.14576984196766e-27 1.59552238121866 0.659090909090909 4.1 4 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.12091219687529e-07 2.24909199263998e-06 1.59552238121866 0.659090909090909 4.1 4 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.12091219687529e-07 2.24909199263998e-06 1.59552238121866 0.659090909090909 4.1 4 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.98806142430883e-42 2.82901140679147e-40 1.58910923858207 0.656441717791411 4.1 4 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.13266702950418e-08 6.1052469052441e-08 1.58603651688323 0.655172413793103 4.1 4 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.85433982373148e-08 1.45120779644345e-07 1.58451877858957 0.654545454545455 4.1 4 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.85433982373148e-08 1.45120779644345e-07 1.58451877858957 0.654545454545455 4.1 4 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.85433982373148e-08 1.45120779644345e-07 1.58451877858957 0.654545454545455 4.1 4 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 2.85433982373148e-08 1.45120779644345e-07 1.58451877858957 0.654545454545455 4.1 4 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 7.20117729393971e-08 3.52140044305024e-07 1.58282591664663 0.653846153846154 4.1 4 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000143498793011634 0.00044103408737701 1.58282591664663 0.653846153846154 4.1 4 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.56053665487224e-10 1.90766683763518e-09 1.58023959978936 0.652777777777778 4.1 4 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 4.60202065003414e-07 2.0528762962378e-06 1.57877776852221 0.652173913043478 4.1 4 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 1.16616446876412e-06 4.88074129132747e-06 1.57633005105164 0.651162790697674 4.1 4 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.4672003990056e-11 1.31309821873268e-10 1.57497348474264 0.650602409638554 4.1 4 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000973788082575337 0.00265969374569041 1.57351517596047 0.65 4.1 4 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 6.44908031852354e-08 3.16449699767552e-07 1.56903222674121 0.648148148148148 4.1 4 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00256926993591156 0.00641415985754764 1.5663951977887 0.647058823529412 4.1 4 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00256926993591156 0.00641415985754764 1.5663951977887 0.647058823529412 4.1 4 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00256926993591156 0.00641415985754764 1.5663951977887 0.647058823529412 4.1 4 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00256926993591156 0.00641415985754764 1.5663951977887 0.647058823529412 4.1 4 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00256926993591156 0.00641415985754764 1.5663951977887 0.647058823529412 4.1 4 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.75536856557754e-14 2.62935733559668e-13 1.56251157333138 0.645454545454546 4.1 4 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 4.89423640276612e-23 1.88229686517194e-21 1.56094821995238 0.644808743169399 4.1 4 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000126286499341883 0.000389817111851408 1.55622380040047 0.642857142857143 4.1 4 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00686398505975445 0.0157539528065009 1.55622380040047 0.642857142857143 4.1 4 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.69150250510612e-05 6.03260166608023e-05 1.54661748064491 0.638888888888889 4.1 4 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000844713221334125 0.00231159021915088 1.54050436807319 0.636363636363636 4.1 4 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0186675244196495 0.0385542630611919 1.54050436807319 0.636363636363636 4.1 4 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0186675244196495 0.0385542630611919 1.54050436807319 0.636363636363636 4.1 4 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0186675244196495 0.0385542630611919 1.54050436807319 0.636363636363636 4.1 4 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0186675244196495 0.0385542630611919 1.54050436807319 0.636363636363636 4.1 4 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0186675244196495 0.0385542630611919 1.54050436807319 0.636363636363636 4.1 4 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0186675244196495 0.0385542630611919 1.54050436807319 0.636363636363636 4.1 4 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 1.27398761844096e-07 6.02287169781225e-07 1.54050436807319 0.636363636363636 4.1 4 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 5.64145675101679e-16 9.44446230199634e-15 1.53378461074244 0.633587786259542 4.1 4 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 5.64145675101679e-16 9.44446230199634e-15 1.53378461074244 0.633587786259542 4.1 4 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 4.46950156172655e-08 2.23947208532989e-07 1.53316863298713 0.633333333333333 4.1 4 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 4.46950156172655e-08 2.23947208532989e-07 1.53316863298713 0.633333333333333 4.1 4 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 8.03749389054548e-07 3.39387353301075e-06 1.53152183531475 0.63265306122449 4.1 4 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 8.08260422930887e-32 6.05344516752975e-30 1.52938159285244 0.631768953068592 4.1 4 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.02122487969033e-06 8.10198029239249e-06 1.52615184290481 0.630434782608696 4.1 4 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 2.02122487969033e-06 8.10198029239249e-06 1.52615184290481 0.630434782608696 4.1 4 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000281890965676643 0.000827073905480131 1.52420273454861 0.62962962962963 4.1 4 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000281890965676643 0.000827073905480131 1.52420273454861 0.62962962962963 4.1 4 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.36901893888466e-20 6.61002735300562e-19 1.51812415933605 0.627118644067797 4.1 4 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.81531159994588e-09 2.77416534685141e-08 1.51299536150045 0.625 4.1 4 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 1.7582816344959e-06 7.18975507438986e-06 1.51299536150045 0.625 4.1 4 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000725013992471647 0.00199168901792887 1.51299536150045 0.625 4.1 4 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00580865538044999 0.0134620791634859 1.51299536150045 0.625 4.1 4 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0521852020851524 0.0958187646028024 1.51299536150045 0.625 4.1 4 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0521852020851524 0.0958187646028024 1.51299536150045 0.625 4.1 4 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0521852020851524 0.0958187646028024 1.51299536150045 0.625 4.1 4 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0521852020851524 0.0958187646028024 1.51299536150045 0.625 4.1 4 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0521852020851524 0.0958187646028024 1.51299536150045 0.625 4.1 4 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 4.40863641381879e-06 1.7093977157668e-05 1.50627093767156 0.622222222222222 4.1 4 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 2.11822742283256e-07 9.85044974735534e-07 1.50256091073149 0.620689655172414 4.1 4 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 2.11822742283256e-07 9.85044974735534e-07 1.50256091073149 0.620689655172414 4.1 4 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 2.11822742283256e-07 9.85044974735534e-07 1.50256091073149 0.620689655172414 4.1 4 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.21160770469831e-20 3.83137280841264e-19 1.50166812349992 0.620320855614973 4.1 4 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.52223539445094e-06 6.29692141367352e-06 1.50089139860845 0.62 4.1 4 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00187335046822668 0.00481187313409126 1.49858588186712 0.619047619047619 4.1 4 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00061731132396795 0.00170569711457552 1.48971850978506 0.615384615384615 4.1 4 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00061731132396795 0.00170569711457552 1.48971850978506 0.615384615384615 4.1 4 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 6.96989496169249e-05 0.000222341768017245 1.479373242356 0.611111111111111 4.1 4 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 2.37225292029271e-05 8.43928976394131e-05 1.4760930356102 0.609756097560976 4.1 4 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.72218678522791e-14 9.02421867488615e-13 1.46714701721256 0.606060606060606 4.1 4 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000175079871972186 0.000525608982735065 1.46714701721256 0.606060606060606 4.1 4 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.000175079871972186 0.000525608982735065 1.46714701721256 0.606060606060606 4.1 4 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000175079871972186 0.000525608982735065 1.46714701721256 0.606060606060606 4.1 4 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.000175079871972186 0.000525608982735065 1.46714701721256 0.606060606060606 4.1 4 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.30502397672032e-50 4.10006139859126e-48 1.45519553870156 0.601123595505618 4.1 4 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.58923251941552e-15 2.56986122173668e-14 1.45247554704044 0.6 4.1 4 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 8.45871774914639e-08 4.10810763038748e-07 1.45247554704044 0.6 4.1 4 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.43244574227173e-07 1.11657106169441e-06 1.45247554704044 0.6 4.1 4 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00132393340841764 0.0034713677920947 1.45247554704044 0.6 4.1 4 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00405291611115919 0.00970925862993185 1.45247554704044 0.6 4.1 4 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.012737468060444 0.0270125440387657 1.45247554704044 0.6 4.1 4 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.012737468060444 0.0270125440387657 1.45247554704044 0.6 4.1 4 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0419205403054578 0.0778758862332461 1.45247554704044 0.6 4.1 4 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0419205403054578 0.0778758862332461 1.45247554704044 0.6 4.1 4 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0419205403054578 0.0778758862332461 1.45247554704044 0.6 4.1 4 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0419205403054578 0.0778758862332461 1.45247554704044 0.6 4.1 4 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0419205403054578 0.0778758862332461 1.45247554704044 0.6 4.1 4 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0419205403054578 0.0778758862332461 1.45247554704044 0.6 4.1 4 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0419205403054578 0.0778758862332461 1.45247554704044 0.6 4.1 4 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0419205403054578 0.0778758862332461 1.45247554704044 0.6 4.1 4 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 5.04678245809138e-07 2.23030168877765e-06 1.43734559342543 0.59375 4.1 4 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 1.80902419613803e-08 9.49904587123403e-08 1.43454375016339 0.592592592592593 4.1 4 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.52413379144085e-24 2.57884510700565e-22 1.43385406566812 0.592307692307692 4.1 4 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00335915982484925 0.00828437509663862 1.43046834178225 0.590909090909091 4.1 4 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.69390932236605e-13 2.94879458902068e-12 1.42809346351698 0.589928057553957 4.1 4 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.29610145703871e-08 6.93365553897023e-08 1.42399563435337 0.588235294117647 4.1 4 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0104363488726477 0.0222652540416458 1.42399563435337 0.588235294117647 4.1 4 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0104363488726477 0.0222652540416458 1.42399563435337 0.588235294117647 4.1 4 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 2.5083249560867e-05 8.76989290543336e-05 1.41212900406709 0.583333333333333 4.1 4 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0336179389797693 0.0637844362242822 1.41212900406709 0.583333333333333 4.1 4 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0336179389797693 0.0637844362242822 1.41212900406709 0.583333333333333 4.1 4 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0336179389797693 0.0637844362242822 1.41212900406709 0.583333333333333 4.1 4 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0336179389797693 0.0637844362242822 1.41212900406709 0.583333333333333 4.1 4 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.21745909886116e-08 1.15584040208038e-07 1.40743754558182 0.581395348837209 4.1 4 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000763240573285761 0.00209266153330566 1.40562149713591 0.580645161290323 4.1 4 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 1.93943710308759e-09 1.28363674311332e-08 1.40405969547242 0.58 4.1 4 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 4.98742194780537e-17 9.72205675579047e-16 1.40086474080042 0.578680203045685 4.1 4 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 9.9892541201628e-14 1.32847744046651e-12 1.3942539533827 0.575949367088608 4.1 4 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000632197728275796 0.00174344451034197 1.39378966635193 0.575757575757576 4.1 4 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 8.50035318862938e-11 6.87272874285205e-10 1.38897934826271 0.573770491803279 4.1 4 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.21344143044465e-77 4.31681788880683e-75 1.3836562184853 0.571571571571572 4.1 4 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.026963874912755 0.0522746512273165 1.38331004480041 0.571428571428571 4.1 4 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.026963874912755 0.0522746512273165 1.38331004480041 0.571428571428571 4.1 4 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.026963874912755 0.0522746512273165 1.38331004480041 0.571428571428571 4.1 4 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.026963874912755 0.0522746512273165 1.38331004480041 0.571428571428571 4.1 4 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.026963874912755 0.0522746512273165 1.38331004480041 0.571428571428571 4.1 4 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.026963874912755 0.0522746512273165 1.38331004480041 0.571428571428571 4.1 4 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 6.54497791209022e-19 1.47833389982609e-17 1.38182580655492 0.570815450643777 4.1 4 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.93009150584279e-13 4.08213154220021e-12 1.3810932017799 0.57051282051282 4.1 4 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.94576328244552e-06 1.16763820359888e-05 1.37798962155118 0.569230769230769 4.1 4 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 8.72274167938223e-12 7.95670603189802e-11 1.37349933526282 0.567375886524823 4.1 4 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00154691812484663 0.0039877979921318 1.37178246109374 0.566666666666667 4.1 4 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 8.23368336532006e-11 6.69516081648597e-10 1.36990587769964 0.565891472868217 4.1 4 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 5.97324292535468e-07 2.59144045206698e-06 1.36965895883199 0.565789473684211 4.1 4 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000101334909412334 0.000315535177448032 1.36827406605258 0.565217391304348 4.1 4 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.00567301141084719 0.0133944652005548 1.36827406605258 0.565217391304348 4.1 4 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.000356270601320814 0.00103043306032423 1.36557530063631 0.564102564102564 4.1 4 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0216459415061505 0.0442559982230635 1.36169582535041 0.5625 4.1 4 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0216459415061505 0.0442559982230635 1.36169582535041 0.5625 4.1 4 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0216459415061505 0.0442559982230635 1.36169582535041 0.5625 4.1 4 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0216459415061505 0.0442559982230635 1.36169582535041 0.5625 4.1 4 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.037517080499e-16 5.68735105993432e-15 1.36025487738707 0.561904761904762 4.1 4 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.86285813846106e-36 6.10365445689381e-34 1.35800559276138 0.560975609756098 4.1 4 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00104210979106446 0.0028354153588618 1.3527958526357 0.558823529411765 4.1 4 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00104210979106446 0.0028354153588618 1.3527958526357 0.558823529411765 4.1 4 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.017396928343025 0.0362988695485699 1.34488476577818 0.555555555555556 4.1 4 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.017396928343025 0.0362988695485699 1.34488476577818 0.555555555555556 4.1 4 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.017396928343025 0.0362988695485699 1.34488476577818 0.555555555555556 4.1 4 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.017396928343025 0.0362988695485699 1.34488476577818 0.555555555555556 4.1 4 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0896567861136482 0.151702267110251 1.34488476577818 0.555555555555556 4.1 4 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0896567861136482 0.151702267110251 1.34488476577818 0.555555555555556 4.1 4 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0896567861136482 0.151702267110251 1.34488476577818 0.555555555555556 4.1 4 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0896567861136482 0.151702267110251 1.34488476577818 0.555555555555556 4.1 4 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0896567861136482 0.151702267110251 1.34488476577818 0.555555555555556 4.1 4 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0037654008489207 0.00903569208771359 1.34488476577818 0.555555555555556 4.1 4 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0037654008489207 0.00903569208771359 1.34488476577818 0.555555555555556 4.1 4 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 4.40013222556897e-12 4.20227393086218e-11 1.33820210855692 0.552795031055901 4.1 4 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000574124013112644 0.00159566107550643 1.3314359181204 0.55 4.1 4 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0139992104187147 0.0295561964774941 1.3314359181204 0.55 4.1 4 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0139992104187147 0.0295561964774941 1.3314359181204 0.55 4.1 4 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0139992104187147 0.0295561964774941 1.3314359181204 0.55 4.1 4 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 6.9684731590549e-12 6.43905019826956e-11 1.32994160171398 0.549382716049383 4.1 4 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.9734567372545e-13 3.18137514068658e-12 1.32880462183953 0.548913043478261 4.1 4 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 5.63702902125701e-13 5.77085776780484e-12 1.32283747453592 0.546448087431694 4.1 4 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0112788162073331 0.0239906658640285 1.32043231549131 0.545454545454545 4.1 4 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0698241593684279 0.12373571454704 1.32043231549131 0.545454545454545 4.1 4 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0698241593684279 0.12373571454704 1.32043231549131 0.545454545454545 4.1 4 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0698241593684279 0.12373571454704 1.32043231549131 0.545454545454545 4.1 4 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0698241593684279 0.12373571454704 1.32043231549131 0.545454545454545 4.1 4 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0698241593684279 0.12373571454704 1.32043231549131 0.545454545454545 4.1 4 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0698241593684279 0.12373571454704 1.32043231549131 0.545454545454545 4.1 4 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00203560511487751 0.00521425994556788 1.32043231549131 0.545454545454545 4.1 4 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.44516698727175e-06 9.71919727063604e-06 1.31764659330672 0.544303797468354 4.1 4 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.94528205204574e-18 6.16343582361925e-17 1.31719596177687 0.544117647058823 4.1 4 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 2.01629759684023e-06 8.10198029239249e-06 1.31499843764978 0.54320987654321 4.1 4 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 5.06025941565259e-05 0.000170633866077574 1.31297224591226 0.542372881355932 4.1 4 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 5.65211020169026e-08 2.80242258432238e-07 1.31220532287142 0.542056074766355 4.1 4 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.00909765273199743 0.0200401855071708 1.31126264663373 0.541666666666667 4.1 4 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 4.66711784105333e-08 2.33028375011189e-07 1.31033726720773 0.541284403669725 4.1 4 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00135199427931958 0.00351716244876007 1.30853652886526 0.540540540540541 4.1 4 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 3.20472885631294e-11 2.72431420805192e-10 1.30693096257217 0.539877300613497 4.1 4 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000173522651470452 0.000525367517111602 1.30350369606193 0.538461538461538 4.1 4 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00734633747820687 0.0165670970388088 1.30350369606193 0.538461538461538 4.1 4 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0547809402932863 0.0996844987689852 1.30350369606193 0.538461538461538 4.1 4 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0547809402932863 0.0996844987689852 1.30350369606193 0.538461538461538 4.1 4 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0547809402932863 0.0996844987689852 1.30350369606193 0.538461538461538 4.1 4 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0547809402932863 0.0996844987689852 1.30350369606193 0.538461538461538 4.1 4 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0547809402932863 0.0996844987689852 1.30350369606193 0.538461538461538 4.1 4 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0547809402932863 0.0996844987689852 1.30350369606193 0.538461538461538 4.1 4 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0547809402932863 0.0996844987689852 1.30350369606193 0.538461538461538 4.1 4 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 1.97319647880017e-10 1.50152865739713e-09 1.296295380692 0.535483870967742 4.1 4 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 1.3439782895628e-10 1.06248950335993e-09 1.29413439725825 0.534591194968553 4.1 4 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 1.3439782895628e-10 1.06248950335993e-09 1.29413439725825 0.534591194968553 4.1 4 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.3439782895628e-10 1.06248950335993e-09 1.29413439725825 0.534591194968553 4.1 4 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.42720661322492e-10 3.21424235235666e-09 1.29002762401618 0.532894736842105 4.1 4 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.16225352220094e-37 1.29441183711546e-35 1.28757552381501 0.531881804043546 4.1 4 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0342567332188411 0.0648235789500145 1.28159607091803 0.529411764705882 4.1 4 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0342567332188411 0.0648235789500145 1.28159607091803 0.529411764705882 4.1 4 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.79958652662588e-44 2.84534625265404e-42 1.2801374326242 0.528809218950064 4.1 4 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.56113059180265e-10 3.27802466269453e-09 1.27978206374051 0.528662420382166 4.1 4 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.027250461446876 0.0526866938028595 1.27410135705301 0.526315789473684 4.1 4 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.027250461446876 0.0526866938028595 1.27410135705301 0.526315789473684 4.1 4 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.30426802312266e-05 4.68680150733218e-05 1.27246789377474 0.525641025641026 4.1 4 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 5.14688903648275e-08 2.56084723738285e-07 1.26896385158103 0.524193548387097 4.1 4 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 9.69058170394014e-05 0.000302405652734799 1.26803420773371 0.523809523809524 4.1 4 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0217434378807247 0.0443915525168885 1.26803420773371 0.523809523809524 4.1 4 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0173942396216814 0.0362988695485699 1.26302221481777 0.521739130434783 4.1 4 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.13609136202268e-07 5.46168245999416e-07 1.26041266478715 0.520661157024793 4.1 4 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.59559141598763e-05 5.70484066570453e-05 1.25522578139297 0.518518518518518 4.1 4 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0112027307712843 0.0238644998316431 1.25522578139297 0.518518518518518 4.1 4 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.94030902917972e-08 1.01509549578042e-07 1.25393572406369 0.517985611510791 4.1 4 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000325218653203731 0.000952234863187056 1.25362472810038 0.517857142857143 4.1 4 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.85550374563714e-08 1.45120779644345e-07 1.24497904032037 0.514285714285714 4.1 4 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00473571961163545 0.0112879882870306 1.24497904032037 0.514285714285714 4.1 4 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.87721920226553e-13 2.07076195722779e-12 1.23921524846704 0.511904761904762 4.1 4 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.87721920226553e-13 2.07076195722779e-12 1.23921524846704 0.511904761904762 4.1 4 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.87721920226553e-13 2.07076195722779e-12 1.23921524846704 0.511904761904762 4.1 4 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.57401236328116e-05 5.64186295453172e-05 1.238545040112 0.511627906976744 4.1 4 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00203733557957536 0.00521425994556788 1.238545040112 0.511627906976744 4.1 4 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.37030484844391e-08 3.59176157511496e-07 1.22768766476037 0.507142857142857 4.1 4 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 6.04930707723489e-08 2.97860345014023e-07 1.22744412425952 0.507042253521127 4.1 4 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00296062646793135 0.00736533472703901 1.21039628920036 0.5 4.1 4 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0205454509524333 0.0423099518166608 1.21039628920036 0.5 4.1 4 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0205454509524333 0.0423099518166608 1.21039628920036 0.5 4.1 4 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 1.85025524143861e-07 8.6894825365252e-07 1.21039628920036 0.5 4.1 4 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 2.74916602381073e-07 1.25386642688547e-06 1.21039628920036 0.5 4.1 4 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 6.01275897619635e-05 0.000197601755730425 1.21039628920036 0.5 4.1 4 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00558433916830238 0.0132663015634295 1.21039628920036 0.5 4.1 4 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00857032060725794 0.0191754185913963 1.21039628920036 0.5 4.1 4 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0405017124750374 0.0761346589854402 1.21039628920036 0.5 4.1 4 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0511165380946572 0.0944660178035029 1.21039628920036 0.5 4.1 4 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0647993096960703 0.115695630737149 1.21039628920036 0.5 4.1 4 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0647993096960703 0.115695630737149 1.21039628920036 0.5 4.1 4 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.106030379757087 0.178136045329792 1.21039628920036 0.5 4.1 4 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.106030379757087 0.178136045329792 1.21039628920036 0.5 4.1 4 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.106030379757087 0.178136045329792 1.21039628920036 0.5 4.1 4 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.106030379757087 0.178136045329792 1.21039628920036 0.5 4.1 4 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.137393031921839 0.22733754002881 1.21039628920036 0.5 4.1 4 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 9.86703610550091e-06 3.67560009898633e-05 1.21039628920036 0.5 4.1 4 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00158135690317826 0.00406920591902833 1.21039628920036 0.5 4.1 4 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0164672466327822 0.0347153954939986 1.21039628920036 0.5 4.1 4 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 3.90468409720455e-07 1.74728473909499e-06 1.20156127979014 0.496350364963504 4.1 4 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 3.90468409720455e-07 1.74728473909499e-06 1.20156127979014 0.496350364963504 4.1 4 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.0522527707125e-06 4.4300464281772e-06 1.20086560975784 0.496062992125984 4.1 4 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.56530596379147e-06 6.45631996079786e-06 1.20055566896296 0.495934959349593 4.1 4 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.67830277985081e-09 1.72453613381344e-08 1.19778799452119 0.494791666666667 4.1 4 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 6.98431274094929e-05 0.000222341768017245 1.19615633285683 0.494117647058824 4.1 4 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 6.98431274094929e-05 0.000222341768017245 1.19615633285683 0.494117647058824 4.1 4 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 8.54472968005921e-05 0.000267234073290643 1.19581320137867 0.493975903614458 4.1 4 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 5.19398062793923e-07 2.27416444109462e-06 1.1850033600563 0.48951048951049 4.1 4 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.000607106160186629 0.00168403911490365 1.17479639834153 0.485294117647059 4.1 4 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.50372279460539e-08 7.95463768298687e-08 1.17257140516285 0.484375 4.1 4 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.69216817673522e-22 9.82296234742106e-21 1.1701204056718 0.483362521891419 4.1 4 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 8.39125402625655e-58 1.99012574656051e-55 1.16429339632572 0.480955455132343 4.1 4 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0365323024769456 0.0688549224168128 1.16198043763235 0.48 4.1 4 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0365323024769456 0.0688549224168128 1.16198043763235 0.48 4.1 4 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0457873944921818 0.0849484515806711 1.15777036358296 0.478260869565217 4.1 4 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.0725960070776603 0.128487709044167 1.14669122134771 0.473684210526316 4.1 4 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.016914306273086 0.0356051151281086 1.14315205091145 0.472222222222222 4.1 4 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.91676167158895e-06 7.74872687122464e-06 1.14011521434357 0.470967741935484 4.1 4 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0919482665647184 0.155394754538711 1.13919650748269 0.470588235294118 4.1 4 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.00210628333732585 0.0053810434273154 1.13474652112534 0.46875 4.1 4 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0260235823835356 0.0508675243568286 1.13474652112534 0.46875 4.1 4 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0260235823835356 0.0508675243568286 1.13474652112534 0.46875 4.1 4 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.117051463237437 0.195040084527954 1.12970320325367 0.466666666666667 4.1 4 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.117051463237437 0.195040084527954 1.12970320325367 0.466666666666667 4.1 4 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0402739430101226 0.0758066414066196 1.12393941140034 0.464285714285714 4.1 4 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 5.26519183509365e-05 0.000176138577548933 1.12036681314414 0.462809917355372 4.1 4 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 5.26519183509365e-05 0.000176138577548933 1.12036681314414 0.462809917355372 4.1 4 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.01180437267716e-14 2.89406800829446e-13 1.11812392634652 0.461883408071749 4.1 4 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0502353180693849 0.0930792416832483 1.1172888823388 0.461538461538462 4.1 4 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.149958470726058 0.246694686523908 1.1172888823388 0.461538461538462 4.1 4 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.149958470726058 0.246694686523908 1.1172888823388 0.461538461538462 4.1 4 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.149958470726058 0.246694686523908 1.1172888823388 0.461538461538462 4.1 4 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0627921827836419 0.113825829428181 1.109529931767 0.458333333333333 4.1 4 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0627921827836419 0.113825829428181 1.109529931767 0.458333333333333 4.1 4 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0627921827836419 0.113825829428181 1.109529931767 0.458333333333333 4.1 4 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 7.98036057959812e-06 3.01221567765733e-05 1.10448661389533 0.45625 4.1 4 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0786768808996593 0.13686699452349 1.10036026290942 0.454545454545455 4.1 4 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.193700425716348 0.30866260447297 1.10036026290942 0.454545454545455 4.1 4 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.193700425716348 0.30866260447297 1.10036026290942 0.454545454545455 4.1 4 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.035099048748558 0.0663292780467437 1.10036026290942 0.454545454545455 4.1 4 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0988549753888973 0.166869074707474 1.08935666028033 0.45 4.1 4 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.54003008823155e-10 1.19101239975733e-09 1.08094214062278 0.446524064171123 4.1 4 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.10106825974572e-05 0.000105067146038528 1.07933427062453 0.445859872611465 4.1 4 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.00432049264822942 0.0103328756948411 1.07590781262254 0.444444444444444 4.1 4 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.124613649340767 0.20715563435971 1.07590781262254 0.444444444444444 4.1 4 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.124613649340767 0.20715563435971 1.07590781262254 0.444444444444444 4.1 4 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0052519604755904 0.0124975581216808 1.07206528472032 0.442857142857143 4.1 4 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00251970965949143 0.0063461006114271 1.05251851234814 0.434782608695652 4.1 4 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0277580044030748 0.0534157639880744 1.05251851234814 0.434782608695652 4.1 4 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0414369815752393 0.0777900063081339 1.03748253360031 0.428571428571429 4.1 4 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.200478819515238 0.318394375189938 1.03748253360031 0.428571428571429 4.1 4 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.200478819515238 0.318394375189938 1.03748253360031 0.428571428571429 4.1 4 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00462398314319926 0.0110401476724372 1.03359683122728 0.426966292134831 4.1 4 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0506230254797387 0.0936756375262265 1.02883684582031 0.425 4.1 4 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0732824539198095 0.129541530345204 1.02700291204879 0.424242424242424 4.1 4 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00669154862293466 0.01538299465337 1.02527685673443 0.423529411764706 4.1 4 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00669154862293466 0.01538299465337 1.02527685673443 0.423529411764706 4.1 4 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00669154862293466 0.01538299465337 1.02527685673443 0.423529411764706 4.1 4 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00669154862293466 0.01538299465337 1.02527685673443 0.423529411764706 4.1 4 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00669154862293466 0.01538299465337 1.02527685673443 0.423529411764706 4.1 4 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.162444661895754 0.262084754963331 1.01928108564241 0.421052631578947 4.1 4 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00693820414330474 0.0158986545828062 1.01783324319121 0.420454545454545 4.1 4 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.133393845146236 0.221492930738732 1.00866357433364 0.416666666666667 4.1 4 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.25632188711582 0.385974651180753 1.00866357433364 0.416666666666667 4.1 4 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.203712659479702 0.320290750811034 0.996796944047358 0.411764705882353 4.1 4 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.203712659479702 0.320290750811034 0.996796944047358 0.411764705882353 4.1 4 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00577006828386513 0.0133944652005548 0.990324236618479 0.409090909090909 4.1 4 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 0.000139556331170211 0.000429845582803484 0.987857061141103 0.408071748878924 4.1 4 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.0175021520339545 0.0364649521878729 0.986248828237333 0.407407407407407 4.1 4 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.112517318698876 0.188811491165684 0.983446984975295 0.40625 4.1 4 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0797677024215849 0.138595165501728 0.96831703136029 0.4 4.1 4 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.204837786233658 0.320290750811034 0.96831703136029 0.4 4.1 4 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.13722710547347 0.227327323735445 0.96831703136029 0.4 4.1 4 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.13722710547347 0.227327323735445 0.96831703136029 0.4 4.1 4 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.256097057033773 0.385974651180753 0.96831703136029 0.4 4.1 4 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.256097057033773 0.385974651180753 0.96831703136029 0.4 4.1 4 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.256097057033773 0.385974651180753 0.96831703136029 0.4 4.1 4 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0805666890820332 0.139812681175284 0.958230395616954 0.395833333333333 4.1 4 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.138019980805268 0.228109677916256 0.953645561188165 0.393939393939394 4.1 4 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.167223733573703 0.269184810944999 0.951025655800285 0.392857142857143 4.1 4 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.204630290655997 0.320290750811034 0.947266661113328 0.391304347826087 4.1 4 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0310020565509701 0.0591366306595583 0.941419336044727 0.388888888888889 4.1 4 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0814999422360155 0.141259948601523 0.941419336044727 0.388888888888889 4.1 4 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.167056454495813 0.269184810944999 0.937080998090604 0.387096774193548 4.1 4 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0170470279325559 0.0358314929808376 0.932600419547821 0.385245901639344 4.1 4 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.322799022359421 0.46871735593618 0.931074068615664 0.384615384615385 4.1 4 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.322799022359421 0.46871735593618 0.931074068615664 0.384615384615385 4.1 4 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.322799022359421 0.46871735593618 0.931074068615664 0.384615384615385 4.1 4 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.250996307056616 0.381997588172797 0.92220669653361 0.380952380952381 4.1 4 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.20186699765835 0.319885008538789 0.918231667669241 0.379310344827586 4.1 4 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.20186699765835 0.319885008538789 0.918231667669241 0.379310344827586 4.1 4 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.199779935973976 0.317994238133073 0.907797216900272 0.375 4.1 4 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.31514007499227 0.459942899193846 0.907797216900272 0.375 4.1 4 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.31514007499227 0.459942899193846 0.907797216900272 0.375 4.1 4 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.31514007499227 0.459942899193846 0.907797216900272 0.375 4.1 4 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.243421030684829 0.371397341817659 0.896589843852121 0.37037037037037 4.1 4 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.243421030684829 0.371397341817659 0.896589843852121 0.37037037037037 4.1 4 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.307483903134568 0.451082055835557 0.89187094993711 0.368421052631579 4.1 4 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.307483903134568 0.451082055835557 0.89187094993711 0.368421052631579 4.1 4 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.158898986057165 0.256655229465773 0.889270743085981 0.36734693877551 4.1 4 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.154968201204206 0.250590625356347 0.880288210327537 0.363636363636364 4.1 4 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.18650437036046 0.29819743710442 0.87560582623005 0.361702127659574 4.1 4 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.292746621696459 0.430349630861634 0.871485328224261 0.36 4.1 4 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.292746621696459 0.430349630861634 0.871485328224261 0.36 4.1 4 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.292746621696459 0.430349630861634 0.871485328224261 0.36 4.1 4 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.000667519217436005 0.00183729177255597 0.870507230212786 0.35959595959596 4.1 4 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.180735751163879 0.289299183246568 0.867831301690826 0.358490566037736 4.1 4 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.285752862413233 0.428478738897819 0.864568778000259 0.357142857142857 4.1 4 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.390754690606189 0.545676079227289 0.864568778000259 0.357142857142857 4.1 4 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.390754690606189 0.545676079227289 0.864568778000259 0.357142857142857 4.1 4 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.390754690606189 0.545676079227289 0.864568778000259 0.357142857142857 4.1 4 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.390754690606189 0.545676079227289 0.864568778000259 0.357142857142857 4.1 4 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.390754690606189 0.545676079227289 0.864568778000259 0.357142857142857 4.1 4 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.390754690606189 0.545676079227289 0.864568778000259 0.357142857142857 4.1 4 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.140247509648265 0.231522281008679 0.860018416010784 0.355263157894737 4.1 4 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.113748356978538 0.190652428716679 0.858990914916387 0.354838709677419 4.1 4 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.214154694867367 0.331963105442553 0.857364038183591 0.354166666666667 4.1 4 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0206893519717515 0.0425447223349746 0.854397380612021 0.352941176470588 4.1 4 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.375918665271852 0.528067384680993 0.854397380612021 0.352941176470588 4.1 4 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.362754889158135 0.510583785630095 0.847277402440254 0.35 4.1 4 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.362754889158135 0.510583785630095 0.847277402440254 0.35 4.1 4 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.187742932176661 0.299840844542524 0.842014809878513 0.347826086956522 4.1 4 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.248905140845571 0.379220573258296 0.842014809878513 0.347826086956522 4.1 4 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.243509290172787 0.371397341817659 0.839866812914538 0.346938775510204 4.1 4 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.339970761548622 0.480893035470864 0.837966661754098 0.346153846153846 4.1 4 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0850089189199846 0.145450141161405 0.830388151893272 0.343023255813953 4.1 4 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.151013479854799 0.247796525214714 0.829986026880249 0.342857142857143 4.1 4 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.274358038646386 0.411826465183341 0.823069476656247 0.34 4.1 4 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.314590637758631 0.459942899193846 0.806930859466909 0.333333333333333 4.1 4 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.314590637758631 0.459942899193846 0.806930859466909 0.333333333333333 4.1 4 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.375209929754168 0.52759261861678 0.806930859466909 0.333333333333333 4.1 4 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.436853801305539 0.602367208583122 0.806930859466909 0.333333333333333 4.1 4 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.436853801305539 0.602367208583122 0.806930859466909 0.333333333333333 4.1 4 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.341887275402206 0.482166098015203 0.806930859466909 0.333333333333333 4.1 4 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.341887275402206 0.482166098015203 0.806930859466909 0.333333333333333 4.1 4 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.341887275402206 0.482166098015203 0.806930859466909 0.333333333333333 4.1 4 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.254540836437654 0.3849220087681 0.79776119060933 0.329545454545455 4.1 4 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.260182246164423 0.390960228397016 0.797437555237886 0.329411764705882 4.1 4 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.260182246164423 0.390960228397016 0.797437555237886 0.329411764705882 4.1 4 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.421015327549151 0.584492498636529 0.78090083174217 0.32258064516129 4.1 4 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.421015327549151 0.584492498636529 0.78090083174217 0.32258064516129 4.1 4 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.436794831249234 0.602367208583122 0.778111900200233 0.321428571428571 4.1 4 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.318825477505234 0.464369144820827 0.772593376085338 0.319148936170213 4.1 4 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.473997910918662 0.640549883416197 0.770252184036595 0.318181818181818 4.1 4 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.31762140653097 0.463089407268002 0.762454355401804 0.31496062992126 4.1 4 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.523057794847 0.685369467833592 0.756497680750227 0.3125 4.1 4 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.418092356244 0.581569328382416 0.754017360485472 0.311475409836066 4.1 4 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.460640955308517 0.623091330231958 0.749292940933558 0.30952380952381 4.1 4 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.505115719507088 0.664921062773901 0.744859254892531 0.307692307692308 4.1 4 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.493228372190206 0.657754275018808 0.739686621178 0.305555555555556 4.1 4 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.490811452583811 0.657754275018808 0.730805306687012 0.30188679245283 4.1 4 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.402053600021869 0.560904189050118 0.729154391084556 0.301204819277108 4.1 4 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.531904333555454 0.696320024516477 0.726237773520218 0.3 4.1 4 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.535456225177791 0.699682468712578 0.719695090875891 0.297297297297297 4.1 4 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.554324179518276 0.723574586633208 0.717271875081697 0.296296296296296 4.1 4 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.584365765503312 0.755956803919284 0.711997817176684 0.294117647058824 4.1 4 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.533110825786292 0.697258001005416 0.706609725587239 0.291891891891892 4.1 4 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.577268017830759 0.747454403433276 0.702810748567953 0.290322580645161 4.1 4 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.612777797963856 0.784157200092236 0.701439410521966 0.289756097560976 4.1 4 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.601335918825892 0.770207932033523 0.691655022400207 0.285714285714286 4.1 4 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.641101136348609 0.814457993159229 0.672442382889091 0.277777777777778 4.1 4 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.673437452853124 0.845063047098761 0.651751848030965 0.269230769230769 4.1 4 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.736261539786511 0.913426478741243 0.643501824638168 0.265822784810127 4.1 4 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.699497736222205 0.87544879388232 0.640798035459016 0.264705882352941 4.1 4 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.692721904659984 0.867731752052075 0.637050678526507 0.263157894736842 4.1 4 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.740644663219258 0.917264887520456 0.63496198777724 0.262295081967213 4.1 4 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.704303319552384 0.88068859729617 0.631511107408885 0.260869565217391 4.1 4 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.765467764375241 0.938208982520214 0.624720665393736 0.258064516129032 4.1 4 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.738992768913638 0.916016298052358 0.605198144600182 0.25 4.1 4 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.810157947235062 0.98534594779102 0.605198144600182 0.25 4.1 4 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.861919041664414 1 0.598958988470283 0.247422680412371 4.1 4 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.816179678589255 0.990080591201105 0.593779311683197 0.245283018867925 4.1 4 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.801527772482618 0.975683507478842 0.590437214244079 0.24390243902439 4.1 4 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.801527772482618 0.975683507478842 0.590437214244079 0.24390243902439 4.1 4 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.791793903756895 0.965486482473061 0.586858806885025 0.242424242424242 4.1 4 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.783120990866571 0.958195331043104 0.580990218816174 0.24 4.1 4 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.783120990866571 0.958195331043104 0.580990218816174 0.24 4.1 4 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.823199722466345 0.990080591201105 0.573345610673856 0.236842105263158 4.1 4 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.81769800310388 0.990080591201105 0.564851601626836 0.233333333333333 4.1 4 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.966198660774166 1 0.560915353531875 0.231707317073171 4.1 4 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.847031952616996 1 0.558644441169398 0.230769230769231 4.1 4 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.815699766026264 0.990080591201105 0.550180131454711 0.227272727272727 4.1 4 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.815699766026264 0.990080591201105 0.550180131454711 0.227272727272727 4.1 4 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.844854324770685 1 0.537953906311272 0.222222222222222 4.1 4 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.959105238183393 1 0.535367589454007 0.221153846153846 4.1 4 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.952967876803461 1 0.535122569962266 0.221052631578947 4.1 4 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.869889824684927 1 0.518741266800156 0.214285714285714 4.1 4 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.888914432016405 1 0.513501456024396 0.212121212121212 4.1 4 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.917928052414391 1 0.506677516409454 0.209302325581395 4.1 4 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.873149132636978 1 0.504331787166818 0.208333333333333 4.1 4 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.89565616807958 1 0.484158515680145 0.2 4.1 4 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.974697070631072 1 0.477339381656481 0.197183098591549 4.1 4 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.98632175009827 1 0.459644160455834 0.189873417721519 4.1 4 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.946212131663664 1 0.45798778510284 0.189189189189189 4.1 4 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.949839374064856 1 0.440144105163768 0.181818181818182 4.1 4 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.999986590927244 1 0.436691994535033 0.180392156862745 4.1 4 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.959076846151768 1 0.42719869030601 0.176470588235294 4.1 4 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.966739753191634 1 0.414993013440124 0.171428571428571 4.1 4 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999994849628313 1 0.40160614203883 0.165898617511521 4.1 4 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.987933386225065 1 0.395231441371547 0.163265306122449 4.1 4 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.999154034299941 1 0.391239204590016 0.161616161616162 4.1 4 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.970720298272181 1 0.390450415871085 0.161290322580645 4.1 4 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.970720298272181 1 0.390450415871085 0.161290322580645 4.1 4 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.970720298272181 1 0.390450415871085 0.161290322580645 4.1 4 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999998109918137 1 0.364420388146346 0.150537634408602 4.1 4 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.994534466829167 1 0.353032251016773 0.145833333333333 4.1 4 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999999999987 1 0.318196962624838 0.131443298969072 4.1 4 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.317081143770372 0.130982367758186 4.1 4 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999994302276745 1 0.291391699251939 0.12037037037037 4.1 4 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999999999314 1 0.285307696740086 0.117857142857143 4.1 4 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.99982466430053 1 0.254820271410603 0.105263157894737 4.1 4 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.247332333959568 0.102169981916817 4.1 4 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999997472965766 1 0.242079257840073 0.1 4.1 4 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.99996409185324 1 0.230551674133402 0.0952380952380952 4.1 4 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999999999997 1 0.151299536150045 0.0625 4.1 4 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 8.78375754135559e-11 5.55523865837733e-10 1.62285449203649 1 4.3 4 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 1.36543089791286e-06 5.50427242983001e-06 1.62285449203649 1 4.3 4 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 3.58355600798102e-06 1.35984005316187e-05 1.62285449203649 1 4.3 4 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 3.58355600798102e-06 1.35984005316187e-05 1.62285449203649 1 4.3 4 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 9.40454661373259e-06 3.43145380290807e-05 1.62285449203649 1 4.3 4 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 9.40454661373259e-06 3.43145380290807e-05 1.62285449203649 1 4.3 4 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 2.46797484571317e-05 8.44213510925443e-05 1.62285449203649 1 4.3 4 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 2.46797484571317e-05 8.44213510925443e-05 1.62285449203649 1 4.3 4 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 2.46797484571317e-05 8.44213510925443e-05 1.62285449203649 1 4.3 4 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 6.47623792305142e-05 0.000210885276075564 1.62285449203649 1 4.3 4 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 6.47623792305142e-05 0.000210885276075564 1.62285449203649 1 4.3 4 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 6.47623792305142e-05 0.000210885276075564 1.62285449203649 1 4.3 4 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000169935480975078 0.000515603815410526 1.62285449203649 1 4.3 4 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000169935480975078 0.000515603815410526 1.62285449203649 1 4.3 4 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.000169935480975078 0.000515603815410526 1.62285449203649 1 4.3 4 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000169935480975078 0.000515603815410526 1.62285449203649 1 4.3 4 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000169935480975078 0.000515603815410526 1.62285449203649 1 4.3 4 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00116988782865621 0.00301576832748934 1.62285449203649 1 4.3 4 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00116988782865621 0.00301576832748934 1.62285449203649 1 4.3 4 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00116988782865621 0.00301576832748934 1.62285449203649 1 4.3 4 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00116988782865621 0.00301576832748934 1.62285449203649 1 4.3 4 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00116988782865621 0.00301576832748934 1.62285449203649 1 4.3 4 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00116988782865621 0.00301576832748934 1.62285449203649 1 4.3 4 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00116988782865621 0.00301576832748934 1.62285449203649 1 4.3 4 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00306932668412448 0.00717184215354537 1.62285449203649 1 4.3 4 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00306932668412448 0.00717184215354537 1.62285449203649 1 4.3 4 3 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00306932668412448 0.00717184215354537 1.62285449203649 1 4.3 4 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00306932668412448 0.00717184215354537 1.62285449203649 1 4.3 4 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00306932668412448 0.00717184215354537 1.62285449203649 1 4.3 4 3 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.00306932668412448 0.00717184215354537 1.62285449203649 1 4.3 4 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00306932668412448 0.00717184215354537 1.62285449203649 1 4.3 4 3 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00805232359802135 0.0175474065543406 1.62285449203649 1 4.3 4 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 7.55112173289962e-08 3.66879458323581e-07 1.62285449203649 1 4.3 4 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 1.98206715992537e-07 9.06907256776144e-07 1.62285449203649 1 4.3 4 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 1.98206715992537e-07 9.06907256776144e-07 1.62285449203649 1 4.3 4 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 5.20240849337484e-07 2.21647523535102e-06 1.62285449203649 1 4.3 4 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 5.20240849337484e-07 2.21647523535102e-06 1.62285449203649 1 4.3 4 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 5.20240849337484e-07 2.21647523535102e-06 1.62285449203649 1 4.3 4 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.000445886722323283 0.00127665353292964 1.62285449203649 1 4.3 4 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.58992174132372e-09 9.15975157046014e-09 1.62285449203649 1 4.3 4 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.85437643497108e-14 4.93412690497418e-13 1.57777520059104 0.972222222222222 4.3 4 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.33325492710541e-11 9.88136333995311e-11 1.56875934230194 0.966666666666667 4.3 4 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.30506480155547e-17 4.25987949690056e-16 1.55523555486831 0.958333333333333 4.3 4 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 3.51507458186795e-09 1.96927209842444e-08 1.55523555486831 0.958333333333333 4.3 4 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 3.51507458186795e-09 1.96927209842444e-08 1.55523555486831 0.958333333333333 4.3 4 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 5.80941980970529e-17 9.50207401058693e-16 1.55379685407749 0.957446808510638 4.3 4 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 2.22612960845406e-08 1.1519208846655e-07 1.54908837876211 0.954545454545455 4.3 4 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 5.58582819982603e-08 2.78899422047454e-07 1.54557570670142 0.952380952380952 4.3 4 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 5.58582819982603e-08 2.78899422047454e-07 1.54557570670142 0.952380952380952 4.3 4 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 5.58582819982603e-08 2.78899422047454e-07 1.54557570670142 0.952380952380952 4.3 4 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 1.39853533988958e-07 6.52496979889464e-07 1.54171176743467 0.95 4.3 4 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 1.39853533988958e-07 6.52496979889464e-07 1.54171176743467 0.95 4.3 4 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 1.39853533988958e-07 6.52496979889464e-07 1.54171176743467 0.95 4.3 4 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 1.39853533988958e-07 6.52496979889464e-07 1.54171176743467 0.95 4.3 4 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.24638198423236e-35 3.77662597722666e-33 1.53185330556716 0.94392523364486 4.3 4 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 3.49563122279446e-12 2.84244756002087e-11 1.53011994963441 0.942857142857143 4.3 4 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 6.13051596920719e-32 4.36186211209092e-30 1.52449967433731 0.939393939393939 4.3 4 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.35075284951168e-06 1.9880212284217e-05 1.52142608628421 0.9375 4.3 4 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.35075284951168e-06 1.9880212284217e-05 1.52142608628421 0.9375 4.3 4 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 5.35075284951168e-06 1.9880212284217e-05 1.52142608628421 0.9375 4.3 4 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 1.3198091577968e-05 4.70698855023772e-05 1.51466419256739 0.933333333333333 4.3 4 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 1.3198091577968e-05 4.70698855023772e-05 1.51466419256739 0.933333333333333 4.3 4 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 1.3198091577968e-05 4.70698855023772e-05 1.51466419256739 0.933333333333333 4.3 4 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.28371780485414e-13 1.23427732182935e-12 1.50693631403389 0.928571428571429 4.3 4 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.28371780485414e-13 1.23427732182935e-12 1.50693631403389 0.928571428571429 4.3 4 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.14953946918046e-08 6.05849875793999e-08 1.49801953111061 0.923076923076923 4.3 4 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 7.92564338827512e-05 0.000252308513233009 1.49801953111061 0.923076923076923 4.3 4 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 7.92564338827512e-05 0.000252308513233009 1.49801953111061 0.923076923076923 4.3 4 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.79175581092255e-08 1.42534235962141e-07 1.49302613267357 0.92 4.3 4 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.09466083114269e-11 8.28565086551087e-11 1.49127169538489 0.918918918918919 4.3 4 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 6.75829332851997e-08 3.35088899180624e-07 1.48761661770012 0.916666666666667 4.3 4 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000192706968734522 0.000574888923499423 1.48761661770012 0.916666666666667 4.3 4 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000192706968734522 0.000574888923499423 1.48761661770012 0.916666666666667 4.3 4 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.000192706968734522 0.000574888923499423 1.48761661770012 0.916666666666667 4.3 4 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000192706968734522 0.000574888923499423 1.48761661770012 0.916666666666667 4.3 4 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.53545342156918e-10 9.66792132253516e-10 1.47966144862151 0.911764705882353 4.3 4 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 3.9182814113546e-07 1.71034185532442e-06 1.47532226548772 0.909090909090909 4.3 4 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.000465588686964339 0.00131194594366387 1.47532226548772 0.909090909090909 4.3 4 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000465588686964339 0.00131194594366387 1.47532226548772 0.909090909090909 4.3 4 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000465588686964339 0.00131194594366387 1.47532226548772 0.909090909090909 4.3 4 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.000465588686964339 0.00131194594366387 1.47532226548772 0.909090909090909 4.3 4 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000465588686964339 0.00131194594366387 1.47532226548772 0.909090909090909 4.3 4 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.000465588686964339 0.00131194594366387 1.47532226548772 0.909090909090909 4.3 4 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000465588686964339 0.00131194594366387 1.47532226548772 0.909090909090909 4.3 4 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.000465588686964339 0.00131194594366387 1.47532226548772 0.909090909090909 4.3 4 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 8.68504089662236e-13 7.40048694364887e-12 1.47189128347496 0.906976744186046 4.3 4 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 8.8130022418311e-10 5.24723941009441e-09 1.47071188340807 0.90625 4.3 4 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.08578893017816e-46 1.71675294182613e-44 1.47011524572718 0.905882352941176 4.3 4 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.59884372195465e-46 3.69815461634146e-44 1.46921146320464 0.905325443786982 4.3 4 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 9.37808427900579e-07 3.82378622608173e-06 1.46829692136635 0.904761904761905 4.3 4 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 9.37808427900579e-07 3.82378622608173e-06 1.46829692136635 0.904761904761905 4.3 4 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.93579124585151e-12 3.94586008025096e-11 1.46452722452074 0.902439024390244 4.3 4 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.93579124585151e-12 3.94586008025096e-11 1.46452722452074 0.902439024390244 4.3 4 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.8180674197402e-44 6.23282721662755e-42 1.46355589159119 0.901840490797546 4.3 4 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00111649339667616 0.00292053327843781 1.46056904283284 0.9 4.3 4 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 2.79459253924367e-08 1.42534235962141e-07 1.44897722503258 0.892857142857143 4.3 4 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.32648730870601e-31 3.29547453925593e-29 1.44556786685604 0.890756302521008 4.3 4 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.1082205707398e-28 1.07142781148669e-26 1.44419161217926 0.889908256880734 4.3 4 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 1.2490611590739e-05 4.48841926606606e-05 1.44253732625466 0.888888888888889 4.3 4 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 1.2490611590739e-05 4.48841926606606e-05 1.44253732625466 0.888888888888889 4.3 4 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 1.2490611590739e-05 4.48841926606606e-05 1.44253732625466 0.888888888888889 4.3 4 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00265349665310892 0.00630371575521535 1.44253732625466 0.888888888888889 4.3 4 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.1843585015745e-14 1.31667355292227e-13 1.44253732625466 0.888888888888889 4.3 4 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 8.48864771279594e-10 5.07535533416329e-09 1.43738540723232 0.885714285714286 4.3 4 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 6.47061718797333e-14 6.39422795728198e-13 1.43560205064767 0.884615384615385 4.3 4 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 6.47061718797333e-14 6.39422795728198e-13 1.43560205064767 0.884615384615385 4.3 4 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.69589369588195e-72 7.67251345848002e-70 1.43453690592987 0.883959044368601 4.3 4 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 8.78501978009406e-16 1.23773100466078e-14 1.43352146796557 0.883333333333333 4.3 4 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 8.78501978009406e-16 1.23773100466078e-14 1.43352146796557 0.883333333333333 4.3 4 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 8.78501978009406e-16 1.23773100466078e-14 1.43352146796557 0.883333333333333 4.3 4 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 8.78501978009406e-16 1.23773100466078e-14 1.43352146796557 0.883333333333333 4.3 4 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 8.78501978009406e-16 1.23773100466078e-14 1.43352146796557 0.883333333333333 4.3 4 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 8.78501978009406e-16 1.23773100466078e-14 1.43352146796557 0.883333333333333 4.3 4 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 8.78501978009406e-16 1.23773100466078e-14 1.43352146796557 0.883333333333333 4.3 4 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.50700300811907e-13 1.42017568248572e-12 1.43193043414985 0.882352941176471 4.3 4 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.50700300811907e-13 1.42017568248572e-12 1.43193043414985 0.882352941176471 4.3 4 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.50700300811907e-13 1.42017568248572e-12 1.43193043414985 0.882352941176471 4.3 4 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 1.9796748719901e-09 1.12683093713676e-08 1.43193043414985 0.882352941176471 4.3 4 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 2.92713890112803e-05 9.89386854229259e-05 1.43193043414985 0.882352941176471 4.3 4 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 2.92713890112803e-05 9.89386854229259e-05 1.43193043414985 0.882352941176471 4.3 4 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 2.92713890112803e-05 9.89386854229259e-05 1.43193043414985 0.882352941176471 4.3 4 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 2.92713890112803e-05 9.89386854229259e-05 1.43193043414985 0.882352941176471 4.3 4 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 9.69827633821984e-64 1.97152103275526e-61 1.43010165964902 0.881226053639847 4.3 4 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.78982991435951e-17 5.02522527611846e-16 1.42908082134557 0.880597014925373 4.3 4 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 3.58462351242345e-07 1.57923196847634e-06 1.42811195299211 0.88 4.3 4 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 3.58462351242345e-07 1.57923196847634e-06 1.42811195299211 0.88 4.3 4 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 4.59994204930937e-09 2.50793775332078e-08 1.42614485663813 0.878787878787879 4.3 4 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 6.05889545457364e-11 3.84902153207959e-10 1.4249454076418 0.878048780487805 4.3 4 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 6.05889545457364e-11 3.84902153207959e-10 1.4249454076418 0.878048780487805 4.3 4 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 6.05889545457364e-11 3.84902153207959e-10 1.4249454076418 0.878048780487805 4.3 4 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 6.05889545457364e-11 3.84902153207959e-10 1.4249454076418 0.878048780487805 4.3 4 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.686209000939e-22 6.31440896930579e-21 1.42450560967648 0.877777777777778 4.3 4 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 8.11172240571226e-13 6.95360300200515e-12 1.4241376154606 0.877551020408163 4.3 4 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 6.81294626771625e-05 0.000218351858985591 1.41999768053193 0.875 4.3 4 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 6.81294626771625e-05 0.000218351858985591 1.41999768053193 0.875 4.3 4 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 6.81294626771625e-05 0.000218351858985591 1.41999768053193 0.875 4.3 4 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 6.81294626771625e-05 0.000218351858985591 1.41999768053193 0.875 4.3 4 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 6.81294626771625e-05 0.000218351858985591 1.41999768053193 0.875 4.3 4 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 6.81294626771625e-05 0.000218351858985591 1.41999768053193 0.875 4.3 4 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.00623789557298668 0.0140008287071925 1.41999768053193 0.875 4.3 4 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00623789557298668 0.0140008287071925 1.41999768053193 0.875 4.3 4 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00623789557298668 0.0140008287071925 1.41999768053193 0.875 4.3 4 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.00623789557298668 0.0140008287071925 1.41999768053193 0.875 4.3 4 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00623789557298668 0.0140008287071925 1.41999768053193 0.875 4.3 4 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00623789557298668 0.0140008287071925 1.41999768053193 0.875 4.3 4 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00623789557298668 0.0140008287071925 1.41999768053193 0.875 4.3 4 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.50384896343598e-19 3.89086740903526e-18 1.41742987279137 0.873417721518987 4.3 4 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.09242648240919e-17 2.18946885136377e-16 1.41714054234173 0.873239436619718 4.3 4 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.96730708351838e-16 1.20611467870709e-14 1.41677773114297 0.873015873015873 4.3 4 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 7.96730708351838e-16 1.20611467870709e-14 1.41677773114297 0.873015873015873 4.3 4 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.51254818096603e-17 4.5837898224547e-16 1.4142017716318 0.871428571428571 4.3 4 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.83176835376409e-15 2.53068579359834e-14 1.41345391241888 0.870967741935484 4.3 4 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2.4539897176226e-08 1.26522730731049e-07 1.41345391241888 0.870967741935484 4.3 4 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.09796417873974e-20 3.3965283181449e-19 1.41283802836118 0.870588235294118 4.3 4 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.09796417873974e-20 3.3965283181449e-19 1.41283802836118 0.870588235294118 4.3 4 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.09796417873974e-20 3.3965283181449e-19 1.41283802836118 0.870588235294118 4.3 4 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 9.92079288574044e-12 7.58993993355303e-11 1.41117781916217 0.869565217391304 4.3 4 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 9.92079288574044e-12 7.58993993355303e-11 1.41117781916217 0.869565217391304 4.3 4 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.54193590884973e-25 7.07798322030054e-24 1.41051839027471 0.869158878504673 4.3 4 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.51841199101264e-20 6.89173127540576e-19 1.41033783236505 0.869047619047619 4.3 4 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.51841199101264e-20 6.89173127540576e-19 1.41033783236505 0.869047619047619 4.3 4 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 4.2016204445446e-15 5.33830883266694e-14 1.41002111603171 0.868852459016393 4.3 4 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.2016204445446e-15 5.33830883266694e-14 1.41002111603171 0.868852459016393 4.3 4 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.82132771830925e-18 4.3195822385901e-17 1.40932100624222 0.868421052631579 4.3 4 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.82132771830925e-18 4.3195822385901e-17 1.40932100624222 0.868421052631579 4.3 4 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000157356273034711 0.000486778209844336 1.40647389309829 0.866666666666667 4.3 4 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000157356273034711 0.000486778209844336 1.40647389309829 0.866666666666667 4.3 4 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000157356273034711 0.000486778209844336 1.40647389309829 0.866666666666667 4.3 4 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000157356273034711 0.000486778209844336 1.40647389309829 0.866666666666667 4.3 4 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.05571839880106e-96 5.00762427164635e-94 1.40571198958091 0.866197183098592 4.3 4 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.14198218638243e-29 6.2501563508546e-28 1.40562200097649 0.866141732283465 4.3 4 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 9.51201019389015e-18 1.93365578655795e-16 1.40354983095048 0.864864864864865 4.3 4 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 9.51201019389015e-18 1.93365578655795e-16 1.40354983095048 0.864864864864865 4.3 4 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.69544437381746e-09 9.68922628089254e-09 1.40354983095048 0.864864864864865 4.3 4 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.69544437381746e-09 9.68922628089254e-09 1.40354983095048 0.864864864864865 4.3 4 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 4.39568357741302e-06 1.64606782385756e-05 1.40155615221333 0.863636363636364 4.3 4 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 4.39568357741302e-06 1.64606782385756e-05 1.40155615221333 0.863636363636364 4.3 4 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 4.39568357741302e-06 1.64606782385756e-05 1.40155615221333 0.863636363636364 4.3 4 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 4.99605097901729e-14 5.04211386038411e-13 1.39901249313491 0.862068965517241 4.3 4 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 1.28612599747448e-07 6.08025679204714e-07 1.39901249313491 0.862068965517241 4.3 4 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 1.28612599747448e-07 6.08025679204714e-07 1.39901249313491 0.862068965517241 4.3 4 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.28612599747448e-07 6.08025679204714e-07 1.39901249313491 0.862068965517241 4.3 4 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 3.8629346693875e-09 2.14724845099157e-08 1.3974580348092 0.861111111111111 4.3 4 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.8629346693875e-09 2.14724845099157e-08 1.3974580348092 0.861111111111111 4.3 4 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 4.95433382374042e-23 1.95833806421739e-21 1.39565486315138 0.86 4.3 4 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.64350872474941e-12 2.94585961097637e-11 1.39565486315138 0.86 4.3 4 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.55267395014529e-15 4.6809768806081e-14 1.39464057909386 0.859375 4.3 4 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.11594695156726e-19 2.94072687422262e-18 1.39374562257252 0.858823529411765 4.3 4 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.56856091350444e-13 2.40464617099791e-12 1.39101813603128 0.857142857142857 4.3 4 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 2.92252477982481e-07 1.31606100053503e-06 1.39101813603128 0.857142857142857 4.3 4 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 2.92252477982481e-07 1.31606100053503e-06 1.39101813603128 0.857142857142857 4.3 4 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000360279942546055 0.00105706877988255 1.39101813603128 0.857142857142857 4.3 4 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0144659598169341 0.0296614709214657 1.39101813603128 0.857142857142857 4.3 4 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0144659598169341 0.0296614709214657 1.39101813603128 0.857142857142857 4.3 4 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0144659598169341 0.0296614709214657 1.39101813603128 0.857142857142857 4.3 4 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0144659598169341 0.0296614709214657 1.39101813603128 0.857142857142857 4.3 4 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0144659598169341 0.0296614709214657 1.39101813603128 0.857142857142857 4.3 4 3 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0144659598169341 0.0296614709214657 1.39101813603128 0.857142857142857 4.3 4 3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0144659598169341 0.0296614709214657 1.39101813603128 0.857142857142857 4.3 4 3 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0144659598169341 0.0296614709214657 1.39101813603128 0.857142857142857 4.3 4 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 1.00143291149492e-05 3.64460110756335e-05 1.39101813603128 0.857142857142857 4.3 4 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 5.71097530969177e-16 8.93045919306745e-15 1.3876581888428 0.855072463768116 4.3 4 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 5.71097530969177e-16 8.93045919306745e-15 1.3876581888428 0.855072463768116 4.3 4 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 5.79923785397769e-13 5.09402189272238e-12 1.38680292955846 0.854545454545454 4.3 4 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 5.79923785397769e-13 5.09402189272238e-12 1.38680292955846 0.854545454545454 4.3 4 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.79923785397769e-13 5.09402189272238e-12 1.38680292955846 0.854545454545454 4.3 4 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 5.79923785397769e-13 5.09402189272238e-12 1.38680292955846 0.854545454545454 4.3 4 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 5.79923785397769e-13 5.09402189272238e-12 1.38680292955846 0.854545454545454 4.3 4 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 5.79923785397769e-13 5.09402189272238e-12 1.38680292955846 0.854545454545454 4.3 4 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.28551120839265e-18 3.15393525783232e-17 1.38536359076286 0.853658536585366 4.3 4 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 6.03831825395299e-10 3.65639441505324e-09 1.38536359076286 0.853658536585366 4.3 4 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.06132691546305e-17 6.79913905965167e-16 1.38483583320447 0.853333333333333 4.3 4 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.06132691546305e-17 6.79913905965167e-16 1.38483583320447 0.853333333333333 4.3 4 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.06132691546305e-17 6.79913905965167e-16 1.38483583320447 0.853333333333333 4.3 4 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.06132691546305e-17 6.79913905965167e-16 1.38483583320447 0.853333333333333 4.3 4 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.06132691546305e-17 6.79913905965167e-16 1.38483583320447 0.853333333333333 4.3 4 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 4.08873142770696e-14 4.18580202994748e-13 1.38341694403111 0.852459016393443 4.3 4 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.89149662883172e-18 6.53111063940879e-17 1.38243160432738 0.851851851851852 4.3 4 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.89149662883172e-18 6.53111063940879e-17 1.38243160432738 0.851851851851852 4.3 4 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 1.30543736715865e-12 1.10573653182545e-11 1.38243160432738 0.851851851851852 4.3 4 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 6.60492449169047e-07 2.72429204396393e-06 1.38243160432738 0.851851851851852 4.3 4 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 6.60492449169047e-07 2.72429204396393e-06 1.38243160432738 0.851851851851852 4.3 4 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.60492449169047e-07 2.72429204396393e-06 1.38243160432738 0.851851851851852 4.3 4 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 6.60492449169047e-07 2.72429204396393e-06 1.38243160432738 0.851851851851852 4.3 4 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 6.60492449169047e-07 2.72429204396393e-06 1.38243160432738 0.851851851851852 4.3 4 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 6.60492449169047e-07 2.72429204396393e-06 1.38243160432738 0.851851851851852 4.3 4 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 6.49007509700262e-18 1.35814365632864e-16 1.37942631823102 0.85 4.3 4 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 1.35818859239615e-09 7.88858108971312e-09 1.37942631823102 0.85 4.3 4 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.35818859239615e-09 7.88858108971312e-09 1.37942631823102 0.85 4.3 4 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.26547436069756e-05 7.86285369578691e-05 1.37942631823102 0.85 4.3 4 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 2.26547436069756e-05 7.86285369578691e-05 1.37942631823102 0.85 4.3 4 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 2.26547436069756e-05 7.86285369578691e-05 1.37942631823102 0.85 4.3 4 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 7.7760172277768e-29 4.09824907967644e-27 1.37881622255732 0.849624060150376 4.3 4 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.46941754744966e-20 4.18196234004172e-19 1.37855381581595 0.849462365591398 4.3 4 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 2.92951053700928e-12 2.39580085871506e-11 1.37789532342721 0.849056603773585 4.3 4 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.04847099306974e-21 3.63896151984937e-20 1.37696744778854 0.848484848484849 4.3 4 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.45355982356721e-17 2.72159951175808e-16 1.37634494894234 0.848101265822785 4.3 4 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.45355982356721e-17 2.72159951175808e-16 1.37634494894234 0.848101265822785 4.3 4 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.45355982356721e-17 2.72159951175808e-16 1.37634494894234 0.848101265822785 4.3 4 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.48399082270658e-06 5.84963695487941e-06 1.37318457018472 0.846153846153846 4.3 4 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 1.48399082270658e-06 5.84963695487941e-06 1.37318457018472 0.846153846153846 4.3 4 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 1.48399082270658e-06 5.84963695487941e-06 1.37318457018472 0.846153846153846 4.3 4 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.48399082270658e-06 5.84963695487941e-06 1.37318457018472 0.846153846153846 4.3 4 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 1.48399082270658e-06 5.84963695487941e-06 1.37318457018472 0.846153846153846 4.3 4 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.48399082270658e-06 5.84963695487941e-06 1.37318457018472 0.846153846153846 4.3 4 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00081668491041926 0.00218447862317031 1.37318457018472 0.846153846153846 4.3 4 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00081668491041926 0.00218447862317031 1.37318457018472 0.846153846153846 4.3 4 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00081668491041926 0.00218447862317031 1.37318457018472 0.846153846153846 4.3 4 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00081668491041926 0.00218447862317031 1.37318457018472 0.846153846153846 4.3 4 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00081668491041926 0.00218447862317031 1.37318457018472 0.846153846153846 4.3 4 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.19324181272538e-23 4.8513802843092e-22 1.37204970690358 0.845454545454545 4.3 4 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 4.59040519803076e-13 4.18727345948575e-12 1.37103224327221 0.844827586206897 4.3 4 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.10044245560014e-10 1.30520943856725e-09 1.37041045994193 0.844444444444444 4.3 4 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 7.70046097203861e-107 5.47887798160547e-104 1.36677669196229 0.842205323193916 4.3 4 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 6.78482825504228e-09 3.64332475733025e-08 1.36661430908336 0.842105263157895 4.3 4 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 5.0853885966243e-05 0.000167511758634176 1.36661430908336 0.842105263157895 4.3 4 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 5.0853885966243e-05 0.000167511758634176 1.36661430908336 0.842105263157895 4.3 4 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.67407151235142e-10 2.84239477011798e-09 1.36467309557614 0.840909090909091 4.3 4 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 5.05818480254651e-15 5.71253728097118e-14 1.36413855852343 0.840579710144927 4.3 4 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 3.24554252463856e-11 2.35633010844932e-10 1.36319777331065 0.84 4.3 4 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 3.31318159960959e-06 1.26398322151326e-05 1.36319777331065 0.84 4.3 4 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.31318159960959e-06 1.26398322151326e-05 1.36319777331065 0.84 4.3 4 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.31318159960959e-06 1.26398322151326e-05 1.36319777331065 0.84 4.3 4 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 3.31318159960959e-06 1.26398322151326e-05 1.36319777331065 0.84 4.3 4 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 2.21531227388975e-07 1.01038120696959e-06 1.36110376751448 0.838709677419355 4.3 4 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.33466696368658e-25 1.03819721541438e-23 1.35897571284357 0.83739837398374 4.3 4 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 1.03588824773728e-09 6.1164687822828e-09 1.35866887705381 0.837209302325581 4.3 4 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.42636994655568e-21 4.83267722368747e-20 1.35758020006899 0.836538461538462 4.3 4 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 2.47445631247312e-14 2.5701834544885e-13 1.35641569483647 0.835820895522388 4.3 4 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.74676386470137e-15 2.4369068426177e-14 1.35608389060584 0.835616438356164 4.3 4 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 3.84634016486852e-15 4.975765504189e-14 1.35237874336374 0.833333333333333 4.3 4 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 3.84634016486852e-15 4.975765504189e-14 1.35237874336374 0.833333333333333 4.3 4 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 7.74529362187305e-13 6.67972898419719e-12 1.35237874336374 0.833333333333333 4.3 4 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 7.74529362187305e-13 6.67972898419719e-12 1.35237874336374 0.833333333333333 4.3 4 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 1.10498763862625e-11 8.31956301463043e-11 1.35237874336374 0.833333333333333 4.3 4 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 4.90112136625537e-07 2.11342294066103e-06 1.35237874336374 0.833333333333333 4.3 4 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 4.90112136625537e-07 2.11342294066103e-06 1.35237874336374 0.833333333333333 4.3 4 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 7.34651751743813e-06 2.71534920189986e-05 1.35237874336374 0.833333333333333 4.3 4 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000113175276113987 0.000353952566835611 1.35237874336374 0.833333333333333 4.3 4 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000113175276113987 0.000353952566835611 1.35237874336374 0.833333333333333 4.3 4 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000113175276113987 0.000353952566835611 1.35237874336374 0.833333333333333 4.3 4 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00182999727811342 0.00456857215220245 1.35237874336374 0.833333333333333 4.3 4 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00182999727811342 0.00456857215220245 1.35237874336374 0.833333333333333 4.3 4 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00182999727811342 0.00456857215220245 1.35237874336374 0.833333333333333 4.3 4 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00182999727811342 0.00456857215220245 1.35237874336374 0.833333333333333 4.3 4 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00182999727811342 0.00456857215220245 1.35237874336374 0.833333333333333 4.3 4 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00182999727811342 0.00456857215220245 1.35237874336374 0.833333333333333 4.3 4 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00182999727811342 0.00456857215220245 1.35237874336374 0.833333333333333 4.3 4 3 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0329673081675058 0.061808273415495 1.35237874336374 0.833333333333333 4.3 4 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 6.14114498437793e-26 2.91294977092327e-24 1.34821757799955 0.830769230769231 4.3 4 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.70088330257624e-12 1.40718426718953e-11 1.34779440864048 0.830508474576271 4.3 4 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.3356044720547e-20 8.95578332779968e-19 1.34696922839029 0.83 4.3 4 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.47968291140357e-10 2.13430550988245e-09 1.34662394020049 0.829787234042553 4.3 4 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 5.02220717497171e-09 2.71733871102082e-08 1.34578177388392 0.829268292682927 4.3 4 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 5.02220717497171e-09 2.71733871102082e-08 1.34578177388392 0.829268292682927 4.3 4 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 7.31234466517162e-08 3.5880918822549e-07 1.34465086483024 0.828571428571429 4.3 4 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 7.31234466517162e-08 3.5880918822549e-07 1.34465086483024 0.828571428571429 4.3 4 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.44122172016886e-17 2.72159951175808e-16 1.34305199340951 0.827586206896552 4.3 4 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.44122172016886e-17 2.72159951175808e-16 1.34305199340951 0.827586206896552 4.3 4 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.07772389351064e-06 4.35682130814103e-06 1.34305199340951 0.827586206896552 4.3 4 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.85978291085487e-15 3.80324400200605e-14 1.34155971341683 0.826666666666667 4.3 4 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.59375185410158e-19 4.04983730069025e-18 1.34133891688731 0.826530612244898 4.3 4 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 7.61139403150808e-10 4.58941258764237e-09 1.34061892820406 0.826086956521739 4.3 4 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.61689518711862e-05 5.69515309720245e-05 1.34061892820406 0.826086956521739 4.3 4 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.59826672993998e-07 7.38419985943047e-07 1.33646840520652 0.823529411764706 4.3 4 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.000249467139784614 0.00074111010420356 1.33646840520652 0.823529411764706 4.3 4 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000249467139784614 0.00074111010420356 1.33646840520652 0.823529411764706 4.3 4 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.3536692319486e-14 1.49323357911849e-13 1.33385300715328 0.821917808219178 4.3 4 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 2.35439631662724e-06 9.15384141683213e-06 1.33305904702998 0.821428571428571 4.3 4 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.93250043309352e-14 3.02387544658846e-13 1.32983909764102 0.819444444444444 4.3 4 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 6.65497941618461e-30 3.78801428369228e-28 1.32871211535488 0.81875 4.3 4 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.72506966742581e-40 1.63651609116462e-38 1.32779003893895 0.818181818181818 4.3 4 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 3.52982340338622e-05 0.000118186793012202 1.32779003893895 0.818181818181818 4.3 4 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 3.52982340338622e-05 0.000118186793012202 1.32779003893895 0.818181818181818 4.3 4 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00404556459037934 0.00933037019790892 1.32779003893895 0.818181818181818 4.3 4 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00404556459037934 0.00933037019790892 1.32779003893895 0.818181818181818 4.3 4 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00404556459037934 0.00933037019790892 1.32779003893895 0.818181818181818 4.3 4 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00404556459037934 0.00933037019790892 1.32779003893895 0.818181818181818 4.3 4 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00404556459037934 0.00933037019790892 1.32779003893895 0.818181818181818 4.3 4 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 5.17160623181905e-08 2.60964385385763e-07 1.32390761192451 0.815789473684211 4.3 4 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.25454773889862e-11 9.34670907043316e-11 1.32028840030088 0.813559322033898 4.3 4 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.25454773889862e-11 9.34670907043316e-11 1.32028840030088 0.813559322033898 4.3 4 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.16933174993698e-09 6.84756823111244e-09 1.31856927477965 0.8125 4.3 4 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000544005784584093 0.00151788280679052 1.31856927477965 0.8125 4.3 4 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000544005784584093 0.00151788280679052 1.31856927477965 0.8125 4.3 4 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.92755899414942e-13 2.72282120828407e-12 1.31709929788469 0.811594202898551 4.3 4 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 7.6376505198088e-05 0.000244233184037931 1.31373935069621 0.80952380952381 4.3 4 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.09957828626022e-05 3.99158138099054e-05 1.31076708972178 0.807692307692308 4.3 4 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.2557382753974e-15 3.08645727489471e-14 1.31001507188488 0.807228915662651 4.3 4 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.33561266898621e-12 1.11798636939257e-11 1.30797227716374 0.805970149253731 4.3 4 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.33561266898621e-12 1.11798636939257e-11 1.30797227716374 0.805970149253731 4.3 4 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.38220061950703e-07 1.07957690495494e-06 1.30729945191829 0.805555555555556 4.3 4 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.5564085504612e-08 1.80098553996665e-07 1.30619995700498 0.804878048780488 4.3 4 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 4.33798800411285e-13 4.00841359081337e-12 1.30285501473352 0.802816901408451 4.3 4 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 2.59269348377887e-10 1.60408818583362e-09 1.29828359362919 0.8 4.3 4 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 7.55415890996551e-08 3.66879458323581e-07 1.29828359362919 0.8 4.3 4 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 7.55415890996551e-08 3.66879458323581e-07 1.29828359362919 0.8 4.3 4 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.000163650455403312 0.000501884909566624 1.29828359362919 0.8 4.3 4 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000163650455403312 0.000501884909566624 1.29828359362919 0.8 4.3 4 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000163650455403312 0.000501884909566624 1.29828359362919 0.8 4.3 4 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00880150967883999 0.019034267892081 1.29828359362919 0.8 4.3 4 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00880150967883999 0.019034267892081 1.29828359362919 0.8 4.3 4 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00880150967883999 0.019034267892081 1.29828359362919 0.8 4.3 4 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.00880150967883999 0.019034267892081 1.29828359362919 0.8 4.3 4 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00880150967883999 0.019034267892081 1.29828359362919 0.8 4.3 4 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 2.34798611887522e-05 8.09003449675409e-05 1.29828359362919 0.8 4.3 4 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 2.34798611887522e-05 8.09003449675409e-05 1.29828359362919 0.8 4.3 4 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00117197462059143 0.00301576832748934 1.29828359362919 0.8 4.3 4 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.91645088810985e-18 8.57401479043126e-17 1.29516271960605 0.798076923076923 4.3 4 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.59105712960888e-31 5.0937809564306e-29 1.29473637069578 0.797814207650273 4.3 4 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.93693733853739e-12 1.59321493221891e-11 1.29357966756532 0.797101449275362 4.3 4 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 6.2337423974683e-13 5.44209535680821e-12 1.28939124024817 0.794520547945205 4.3 4 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 1.07045573962138e-06 4.33976785607186e-06 1.28873739073486 0.794117647058823 4.3 4 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 1.07045573962138e-06 4.33976785607186e-06 1.28873739073486 0.794117647058823 4.3 4 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.74727228669877e-10 1.0905124841984e-09 1.28709149368412 0.793103448275862 4.3 4 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.74727228669877e-10 1.0905124841984e-09 1.28709149368412 0.793103448275862 4.3 4 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.14915850747315e-09 6.75724196749706e-09 1.28603563519873 0.792452830188679 4.3 4 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 4.96942024154285e-05 0.00016445313962129 1.28475980619556 0.791666666666667 4.3 4 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 4.96942024154285e-05 0.00016445313962129 1.28475980619556 0.791666666666667 4.3 4 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.39172031750969e-20 4.04166941186998e-19 1.28257855015787 0.790322580645161 4.3 4 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.39172031750969e-20 4.04166941186998e-19 1.28257855015787 0.790322580645161 4.3 4 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.39172031750969e-20 4.04166941186998e-19 1.28257855015787 0.790322580645161 4.3 4 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 5.57647182924485e-11 3.60696336955246e-10 1.28257855015787 0.790322580645161 4.3 4 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 3.34831323233007e-07 1.49831752503324e-06 1.28120091476565 0.789473684210526 4.3 4 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000346880489168026 0.00101985730596302 1.28120091476565 0.789473684210526 4.3 4 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.51845599656139e-18 5.87502111984731e-17 1.27509995802867 0.785714285714286 4.3 4 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 1.52016706149684e-05 5.36773629903226e-05 1.27509995802867 0.785714285714286 4.3 4 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00249016979262102 0.00606765687482826 1.27509995802867 0.785714285714286 4.3 4 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00249016979262102 0.00606765687482826 1.27509995802867 0.785714285714286 4.3 4 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.00249016979262102 0.00606765687482826 1.27509995802867 0.785714285714286 4.3 4 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00249016979262102 0.00606765687482826 1.27509995802867 0.785714285714286 4.3 4 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00249016979262102 0.00606765687482826 1.27509995802867 0.785714285714286 4.3 4 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.00249016979262102 0.00606765687482826 1.27509995802867 0.785714285714286 4.3 4 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00249016979262102 0.00606765687482826 1.27509995802867 0.785714285714286 4.3 4 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 4.12295934812018e-33 3.25942841798612e-31 1.27509995802867 0.785714285714286 4.3 4 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 3.29243366411995e-08 1.67326182287239e-07 1.27006003724595 0.782608695652174 4.3 4 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000104163649819496 0.000328658256525815 1.27006003724595 0.782608695652174 4.3 4 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 1.57835354981745e-09 9.13006951784649e-09 1.26877714831944 0.781818181818182 4.3 4 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 3.45542570619798e-18 7.68292309362458e-17 1.26696534904603 0.780701754385965 4.3 4 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 5.85319201850653e-14 5.86555791713717e-13 1.26431687170285 0.779069767441861 4.3 4 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 7.69923600832783e-12 6.0530457678732e-11 1.26222016047283 0.777777777777778 4.3 4 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.44610788580657e-06 5.79665217324717e-06 1.26222016047283 0.777777777777778 4.3 4 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000726488662631804 0.00196165724274204 1.26222016047283 0.777777777777778 4.3 4 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0187832917925588 0.0381292784890316 1.26222016047283 0.777777777777778 4.3 4 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0187832917925588 0.0381292784890316 1.26222016047283 0.777777777777778 4.3 4 3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.0187832917925588 0.0381292784890316 1.26222016047283 0.777777777777778 4.3 4 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0187832917925588 0.0381292784890316 1.26222016047283 0.777777777777778 4.3 4 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.57803103332883e-17 7.57504437258945e-16 1.26222016047283 0.777777777777778 4.3 4 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 3.16051800497588e-05 0.000106573865428452 1.26222016047283 0.777777777777778 4.3 4 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.40385424593933e-31 9.51278377129365e-30 1.25964420096166 0.776190476190476 4.3 4 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.98967493338501e-11 3.24214951150999e-10 1.25952885949101 0.776119402985075 4.3 4 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 2.13067039254012e-08 1.10654889364401e-07 1.25854021831402 0.775510204081633 4.3 4 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.24755495103953e-32 9.3435299754171e-31 1.25170839744519 0.771300448430493 4.3 4 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.36529067974606e-08 7.11651515486681e-08 1.24834960925884 0.769230769230769 4.3 4 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 7.92828462504926e-124 1.12819490214451e-120 1.24467799276102 0.766968325791855 4.3 4 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 1.98001838532932e-05 6.92276698359611e-05 1.24418844389464 0.766666666666667 4.3 4 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 4.22907325636021e-10 2.58282027630926e-09 1.24249797046544 0.765625 4.3 4 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.773163081823e-08 1.42462493336972e-07 1.2410063762632 0.764705882352941 4.3 4 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 6.06647276429735e-06 2.24807050614456e-05 1.2410063762632 0.764705882352941 4.3 4 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0015012563801824 0.00381479969464205 1.2410063762632 0.764705882352941 4.3 4 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0015012563801824 0.00381479969464205 1.2410063762632 0.764705882352941 4.3 4 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0015012563801824 0.00381479969464205 1.2410063762632 0.764705882352941 4.3 4 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0015012563801824 0.00381479969464205 1.2410063762632 0.764705882352941 4.3 4 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0015012563801824 0.00381479969464205 1.2410063762632 0.764705882352941 4.3 4 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.19960992407821e-11 2.7413050100749e-10 1.2396805147501 0.763888888888889 4.3 4 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.30274845416427e-16 5.28068657334355e-15 1.23927070300969 0.763636363636364 4.3 4 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.000442927096060026 0.00127665353292964 1.23646056536114 0.761904761904762 4.3 4 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 8.4217083111968e-14 8.26489029436762e-13 1.22995287817503 0.757894736842105 4.3 4 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 3.61402010476035e-07 1.58378542267324e-06 1.22615672731646 0.755555555555556 4.3 4 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.14176693640722e-23 4.77863044266903e-22 1.219433036389 0.751412429378531 4.3 4 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 7.21850979952933e-07 2.96021309646404e-06 1.21714086902737 0.75 4.3 4 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 7.21850979952933e-07 2.96021309646404e-06 1.21714086902737 0.75 4.3 4 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 7.55501747805223e-06 2.78517872312651e-05 1.21714086902737 0.75 4.3 4 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000267571992031696 0.000793239468043965 1.21714086902737 0.75 4.3 4 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00305588112861346 0.00717184215354537 1.21714086902737 0.75 4.3 4 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00305588112861346 0.00717184215354537 1.21714086902737 0.75 4.3 4 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00305588112861346 0.00717184215354537 1.21714086902737 0.75 4.3 4 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0106922665271771 0.0229488616412865 1.21714086902737 0.75 4.3 4 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0106922665271771 0.0229488616412865 1.21714086902737 0.75 4.3 4 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0106922665271771 0.0229488616412865 1.21714086902737 0.75 4.3 4 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0106922665271771 0.0229488616412865 1.21714086902737 0.75 4.3 4 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0106922665271771 0.0229488616412865 1.21714086902737 0.75 4.3 4 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0391501525487764 0.0718847317121403 1.21714086902737 0.75 4.3 4 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0391501525487764 0.0718847317121403 1.21714086902737 0.75 4.3 4 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0391501525487764 0.0718847317121403 1.21714086902737 0.75 4.3 4 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0391501525487764 0.0718847317121403 1.21714086902737 0.75 4.3 4 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0391501525487764 0.0718847317121403 1.21714086902737 0.75 4.3 4 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0391501525487764 0.0718847317121403 1.21714086902737 0.75 4.3 4 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0391501525487764 0.0718847317121403 1.21714086902737 0.75 4.3 4 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 7.06884002230214e-22 2.51473983793399e-20 1.21714086902737 0.75 4.3 4 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 9.77299766021893e-42 9.9335540503511e-40 1.21465182839541 0.748466257668712 4.3 4 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.44903997221079e-07 1.93017801233413e-06 1.20850866428249 0.74468085106383 4.3 4 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 8.29775695874867e-10 4.98215533852293e-09 1.20554905122711 0.742857142857143 4.3 4 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.50022032633156e-05 5.32372449967533e-05 1.20554905122711 0.742857142857143 4.3 4 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.28041993408716e-17 5.83504695775753e-16 1.20484651681497 0.742424242424242 4.3 4 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.6164321200072e-11 1.19180461490686e-10 1.20282156468587 0.741176470588235 4.3 4 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00016077424292209 0.000496272771536082 1.20211443854555 0.740740740740741 4.3 4 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00053303306294451 0.0014931221428544 1.19950114628784 0.739130434782609 4.3 4 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00053303306294451 0.0014931221428544 1.19950114628784 0.739130434782609 4.3 4 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.98702586193856e-14 2.12596827183351e-13 1.19886548060354 0.738738738738739 4.3 4 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.00085128693557e-11 7.61610364336532e-11 1.19869934070877 0.738636363636364 4.3 4 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 2.81893958713196e-06 1.09004104143717e-05 1.1978211726936 0.738095238095238 4.3 4 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0017893915483304 0.0045227427589239 1.19578752044794 0.736842105263158 4.3 4 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0017893915483304 0.0045227427589239 1.19578752044794 0.736842105263158 4.3 4 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.95150316055569e-11 1.43143762756224e-10 1.19382399414179 0.735632183908046 4.3 4 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.7130856460144e-06 6.73403556430522e-06 1.19009329416009 0.733333333333333 4.3 4 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 9.62918271813641e-05 0.000305174320888822 1.19009329416009 0.733333333333333 4.3 4 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00611520651570237 0.0138786903857169 1.19009329416009 0.733333333333333 4.3 4 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00611520651570237 0.0138786903857169 1.19009329416009 0.733333333333333 4.3 4 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00611520651570237 0.0138786903857169 1.19009329416009 0.733333333333333 4.3 4 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.78999535735186e-11 2.73764639264553e-10 1.18883526742208 0.732558139534884 4.3 4 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.01995064319677e-07 4.88683422649494e-07 1.18816132452672 0.732142857142857 4.3 4 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000316226814365007 0.000931657881659224 1.1859321287959 0.730769230769231 4.3 4 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000316226814365007 0.000931657881659224 1.1859321287959 0.730769230769231 4.3 4 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 6.52280168931204e-22 2.37998635997206e-20 1.18025781239018 0.727272727272727 4.3 4 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.021484029914735 0.0421679649223006 1.18025781239018 0.727272727272727 4.3 4 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.021484029914735 0.0421679649223006 1.18025781239018 0.727272727272727 4.3 4 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.021484029914735 0.0421679649223006 1.18025781239018 0.727272727272727 4.3 4 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.021484029914735 0.0421679649223006 1.18025781239018 0.727272727272727 4.3 4 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.021484029914735 0.0421679649223006 1.18025781239018 0.727272727272727 4.3 4 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.021484029914735 0.0421679649223006 1.18025781239018 0.727272727272727 4.3 4 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.021484029914735 0.0421679649223006 1.18025781239018 0.727272727272727 4.3 4 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 1.19250804877042e-08 6.23874615220703e-08 1.18025781239018 0.727272727272727 4.3 4 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 7.66180314200525e-60 1.36284323388418e-57 1.17915270207895 0.726591760299625 4.3 4 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 8.72822225562817e-12 6.75014145095592e-11 1.1787048415844 0.726315789473684 4.3 4 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 8.72822225562817e-12 6.75014145095592e-11 1.1787048415844 0.726315789473684 4.3 4 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.81384200531409e-31 1.1732259879827e-29 1.17759477580987 0.725631768953069 4.3 4 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 5.95111061471074e-18 1.26394483652737e-16 1.17264324585863 0.72258064516129 4.3 4 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00351565244581393 0.00820126791867742 1.17206157758191 0.722222222222222 4.3 4 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.41869365009146e-14 2.53073607652952e-13 1.17058356802632 0.721311475409836 4.3 4 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 7.24420499835414e-08 3.57934156689512e-07 1.17058356802632 0.721311475409836 4.3 4 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.7273121426623e-15 5.71253728097118e-14 1.16996486635189 0.720930232558139 4.3 4 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 6.21600213279967e-12 4.94154806423125e-11 1.16845523426627 0.72 4.3 4 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.000614369529627733 0.0017108568310377 1.16845523426627 0.72 4.3 4 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 3.83769525693446e-06 1.45240434856855e-05 1.16422170080879 0.717391304347826 4.3 4 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 6.52540670881257e-16 1.00931018985221e-14 1.16247023897649 0.716312056737589 4.3 4 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 9.8259311921994e-10 5.82595836937489e-09 1.1620439572607 0.716049382716049 4.3 4 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.012001543614943 0.0254518577705869 1.15918178002607 0.714285714285714 4.3 4 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.012001543614943 0.0254518577705869 1.15918178002607 0.714285714285714 4.3 4 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.012001543614943 0.0254518577705869 1.15918178002607 0.714285714285714 4.3 4 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.012001543614943 0.0254518577705869 1.15918178002607 0.714285714285714 4.3 4 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.012001543614943 0.0254518577705869 1.15918178002607 0.714285714285714 4.3 4 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.012001543614943 0.0254518577705869 1.15918178002607 0.714285714285714 4.3 4 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.012001543614943 0.0254518577705869 1.15918178002607 0.714285714285714 4.3 4 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.012001543614943 0.0254518577705869 1.15918178002607 0.714285714285714 4.3 4 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0792206790439349 0.131082588697116 1.15918178002607 0.714285714285714 4.3 4 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0792206790439349 0.131082588697116 1.15918178002607 0.714285714285714 4.3 4 3 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0792206790439349 0.131082588697116 1.15918178002607 0.714285714285714 4.3 4 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0792206790439349 0.131082588697116 1.15918178002607 0.714285714285714 4.3 4 3 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0792206790439349 0.131082588697116 1.15918178002607 0.714285714285714 4.3 4 3 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.0792206790439349 0.131082588697116 1.15918178002607 0.714285714285714 4.3 4 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0792206790439349 0.131082588697116 1.15918178002607 0.714285714285714 4.3 4 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.32346297891379e-08 4.01501281999808e-07 1.15918178002607 0.714285714285714 4.3 4 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 6.58335585657908e-05 0.000213883912874704 1.15918178002607 0.714285714285714 4.3 4 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.02234768761807e-22 3.93189394454193e-21 1.15918178002607 0.714285714285714 4.3 4 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.32782829347541e-15 3.15476158249096e-14 1.15584600511952 0.712230215827338 4.3 4 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 1.37656459166443e-06 5.53347857044769e-06 1.15472338856443 0.711538461538462 4.3 4 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 2.23861577496882e-14 2.35966685020787e-13 1.15210280732362 0.709923664122137 4.3 4 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 2.23861577496882e-14 2.35966685020787e-13 1.15210280732362 0.709923664122137 4.3 4 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00117772423516134 0.00302509311666894 1.14952193185918 0.708333333333333 4.3 4 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 9.75370589097946e-27 4.78604258029785e-25 1.14848164051813 0.707692307692308 4.3 4 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 2.31538833360435e-05 8.01653916963258e-05 1.14787268948923 0.707317073170732 4.3 4 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00678698052484798 0.0151377324245434 1.14554434731988 0.705882352941177 4.3 4 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00678698052484798 0.0151377324245434 1.14554434731988 0.705882352941177 4.3 4 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00678698052484798 0.0151377324245434 1.14554434731988 0.705882352941177 4.3 4 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 3.93988157736374e-09 2.18149863213565e-08 1.14200871661827 0.703703703703704 4.3 4 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000685426671541936 0.00185430067225128 1.14200871661827 0.703703703703704 4.3 4 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000685426671541936 0.00185430067225128 1.14200871661827 0.703703703703704 4.3 4 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.42312743338981e-16 3.91830720194738e-15 1.14010663681045 0.70253164556962 4.3 4 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 4.34421976960307e-05 0.000144435157293111 1.13599814442555 0.7 4.3 4 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00387264045002293 0.00900452183069058 1.13599814442555 0.7 4.3 4 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00387264045002293 0.00900452183069058 1.13599814442555 0.7 4.3 4 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0420741167245695 0.0757866684798257 1.13599814442555 0.7 4.3 4 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0420741167245695 0.0757866684798257 1.13599814442555 0.7 4.3 4 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0420741167245695 0.0757866684798257 1.13599814442555 0.7 4.3 4 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0420741167245695 0.0757866684798257 1.13599814442555 0.7 4.3 4 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0420741167245695 0.0757866684798257 1.13599814442555 0.7 4.3 4 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0420741167245695 0.0757866684798257 1.13599814442555 0.7 4.3 4 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0420741167245695 0.0757866684798257 1.13599814442555 0.7 4.3 4 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0420741167245695 0.0757866684798257 1.13599814442555 0.7 4.3 4 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 2.56726243026952e-05 8.76070608698687e-05 1.13222406421151 0.697674418604651 4.3 4 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.5187680016664e-05 5.36773629903226e-05 1.12894225532973 0.695652173913043 4.3 4 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 8.99367647027925e-06 3.29845402505345e-05 1.12606230059675 0.693877551020408 4.3 4 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0230325295798641 0.0447139012171168 1.12351464833296 0.692307692307692 4.3 4 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0230325295798641 0.0447139012171168 1.12351464833296 0.692307692307692 4.3 4 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0230325295798641 0.0447139012171168 1.12351464833296 0.692307692307692 4.3 4 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0230325295798641 0.0447139012171168 1.12351464833296 0.692307692307692 4.3 4 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 3.61721899064513e-07 1.58378542267324e-06 1.12351464833296 0.692307692307692 4.3 4 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 3.16202579429126e-06 1.21939368706679e-05 1.12124492177067 0.690909090909091 4.3 4 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 1.87709590814988e-06 7.31810267752678e-06 1.11920999450793 0.689655172413793 4.3 4 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 1.87709590814988e-06 7.31810267752678e-06 1.11920999450793 0.689655172413793 4.3 4 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 1.87709590814988e-06 7.31810267752678e-06 1.11920999450793 0.689655172413793 4.3 4 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 1.65462684690176e-05 5.81366420528691e-05 1.11571246327509 0.6875 4.3 4 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000434165393587521 0.00126861879892206 1.11571246327509 0.6875 4.3 4 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.012845722367298 0.0272015817390849 1.11571246327509 0.6875 4.3 4 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 2.34617169483749e-07 1.0666461091865e-06 1.11281450882502 0.685714285714286 4.3 4 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 8.32117798025823e-08 4.01501281999808e-07 1.11037412613023 0.684210526315789 4.3 4 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 2.64652463015346e-10 1.63030499944086e-09 1.10718110204359 0.682242990654206 4.3 4 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 9.77015323825209e-85 3.47573201450818e-82 1.10627017925611 0.681681681681682 4.3 4 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 8.96721451029041e-08 4.31092778653488e-07 1.10270882151198 0.67948717948718 4.3 4 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 5.71190369640548e-08 2.84197166433042e-07 1.09493797053065 0.674698795180723 4.3 4 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 5.45504792119038e-05 0.000179273283876534 1.09366280985068 0.673913043478261 4.3 4 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.56820834468007e-15 3.44769856082994e-14 1.08484294848092 0.668478260869565 4.3 4 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000486016007858828 0.0013667999588599 1.081902994691 0.666666666666667 4.3 4 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.013329636682916 0.0280205069752769 1.081902994691 0.666666666666667 4.3 4 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.013329636682916 0.0280205069752769 1.081902994691 0.666666666666667 4.3 4 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.013329636682916 0.0280205069752769 1.081902994691 0.666666666666667 4.3 4 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.013329636682916 0.0280205069752769 1.081902994691 0.666666666666667 4.3 4 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0798838740612113 0.131568000913314 1.081902994691 0.666666666666667 4.3 4 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0798838740612113 0.131568000913314 1.081902994691 0.666666666666667 4.3 4 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0798838740612113 0.131568000913314 1.081902994691 0.666666666666667 4.3 4 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 9.7669357259029e-05 0.000308852211954663 1.081902994691 0.666666666666667 4.3 4 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000834166935585012 0.00222705356348494 1.081902994691 0.666666666666667 4.3 4 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00248471857382273 0.00606765687482826 1.081902994691 0.666666666666667 4.3 4 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0237742178134241 0.0458410731009519 1.081902994691 0.666666666666667 4.3 4 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0237742178134241 0.0458410731009519 1.081902994691 0.666666666666667 4.3 4 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0237742178134241 0.0458410731009519 1.081902994691 0.666666666666667 4.3 4 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0237742178134241 0.0458410731009519 1.081902994691 0.666666666666667 4.3 4 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0430675566898509 0.0769913733287158 1.081902994691 0.666666666666667 4.3 4 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0430675566898509 0.0769913733287158 1.081902994691 0.666666666666667 4.3 4 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0430675566898509 0.0769913733287158 1.081902994691 0.666666666666667 4.3 4 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00755656269713376 0.0167492036106251 1.081902994691 0.666666666666667 4.3 4 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.67421593383014e-21 5.5404866833495e-20 1.07991420242134 0.665441176470588 4.3 4 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 1.23370879355875e-05 4.46709316344553e-05 1.07273432524446 0.661016949152542 4.3 4 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 4.25241549376457e-18 9.16846552670756e-17 1.07261627370652 0.660944206008584 4.3 4 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.48778485579041e-12 1.23808061391214e-11 1.0715000812805 0.66025641025641 4.3 4 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.33454284737425e-07 1.49686260940491e-06 1.06870905573135 0.658536585365854 4.3 4 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 6.27245843551298e-15 7.02811681396455e-14 1.06268136788176 0.654822335025381 4.3 4 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 5.81529717248988e-07 2.46284758227771e-06 1.06186775404857 0.654320987654321 4.3 4 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.000178517253597391 0.000540489472061887 1.05838336437163 0.652173913043478 4.3 4 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 9.98180027105724e-09 5.33988788936633e-08 1.05708870582194 0.651376146788991 4.3 4 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 3.57837979302192e-07 1.57923196847634e-06 1.05674245993074 0.651162790697674 4.3 4 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.84875517129761e-34 4.05869329926853e-32 1.0555151167717 0.650406504065041 4.3 4 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0135390517081335 0.0281310115836628 1.05485541982372 0.65 4.3 4 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0135390517081335 0.0281310115836628 1.05485541982372 0.65 4.3 4 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 8.62532441189862e-12 6.74386628468777e-11 1.05128309861484 0.647798742138365 4.3 4 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 6.17148326996614e-07 2.59056657615393e-06 1.05008231837655 0.647058823529412 4.3 4 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 6.17148326996614e-07 2.59056657615393e-06 1.05008231837655 0.647058823529412 4.3 4 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 8.04647467925246e-06 2.95869081875355e-05 1.05008231837655 0.647058823529412 4.3 4 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00151508484775358 0.00384307618244802 1.05008231837655 0.647058823529412 4.3 4 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.023953415745123 0.0460617710882569 1.05008231837655 0.647058823529412 4.3 4 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.023953415745123 0.0460617710882569 1.05008231837655 0.647058823529412 4.3 4 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000182592353071402 0.000550484996653826 1.0480935261069 0.645833333333333 4.3 4 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00260327083051725 0.00630371575521535 1.04700289808806 0.645161290322581 4.3 4 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.37576743566159e-13 4.01723681351383e-12 1.04643076535686 0.644808743169399 4.3 4 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 4.0999793125889e-11 2.7413050100749e-10 1.04631408039195 0.644736842105263 4.3 4 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.24814211658351e-42 4.65008171684488e-40 1.04488609596129 0.643856920684292 4.3 4 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.52103580228676e-11 1.83970971623285e-10 1.04400193436743 0.643312101910828 4.3 4 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0428883043167222 0.0769609798772959 1.04326360202346 0.642857142857143 4.3 4 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0428883043167222 0.0769609798772959 1.04326360202346 0.642857142857143 4.3 4 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0428883043167222 0.0769609798772959 1.04326360202346 0.642857142857143 4.3 4 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00777604929468303 0.0171821710346801 1.03862687490336 0.64 4.3 4 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.14257809791295e-08 6.04419566293726e-08 1.0327255858414 0.636363636363636 4.3 4 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.14257809791295e-08 6.04419566293726e-08 1.0327255858414 0.636363636363636 4.3 4 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0135416324208074 0.0281310115836628 1.0327255858414 0.636363636363636 4.3 4 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0135416324208074 0.0281310115836628 1.0327255858414 0.636363636363636 4.3 4 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0135416324208074 0.0281310115836628 1.0327255858414 0.636363636363636 4.3 4 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0781067686417797 0.130452971569545 1.0327255858414 0.636363636363636 4.3 4 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0781067686417797 0.130452971569545 1.0327255858414 0.636363636363636 4.3 4 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0781067686417797 0.130452971569545 1.0327255858414 0.636363636363636 4.3 4 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0781067686417797 0.130452971569545 1.0327255858414 0.636363636363636 4.3 4 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00262127984205948 0.00630371575521535 1.0327255858414 0.636363636363636 4.3 4 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00262127984205948 0.00630371575521535 1.0327255858414 0.636363636363636 4.3 4 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000187191670644138 0.000563158028174648 1.02988842763854 0.634615384615385 4.3 4 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.15715502140158e-08 6.07613134854037e-08 1.02912723885241 0.634146341463415 4.3 4 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.00449826960079289 0.0102580731441158 1.02780784495645 0.633333333333333 4.3 4 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 3.97852825452408e-05 0.000132586550496201 1.02364667959225 0.630769230769231 4.3 4 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 4.03958526432183e-07 1.75789903092659e-06 1.02239832998299 0.63 4.3 4 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00774535944423818 0.0171409743221632 1.02179727276372 0.62962962962963 4.3 4 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.61625138097513e-09 1.47735147425699e-08 1.02007996642294 0.628571428571429 4.3 4 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.61625138097513e-09 1.47735147425699e-08 1.02007996642294 0.628571428571429 4.3 4 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 4.35104103956831e-09 2.38135823050219e-08 1.01574345904442 0.62589928057554 4.3 4 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.44084937138564e-12 5.09184925304543e-11 1.01428405752281 0.625 4.3 4 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0133899822510108 0.0280205069752769 1.01428405752281 0.625 4.3 4 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0133899822510108 0.0280205069752769 1.01428405752281 0.625 4.3 4 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0133899822510108 0.0280205069752769 1.01428405752281 0.625 4.3 4 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0133899822510108 0.0280205069752769 1.01428405752281 0.625 4.3 4 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.041988376890301 0.0757866684798257 1.01428405752281 0.625 4.3 4 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.041988376890301 0.0757866684798257 1.01428405752281 0.625 4.3 4 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.041988376890301 0.0757866684798257 1.01428405752281 0.625 4.3 4 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.146004889869199 0.226817640047893 1.01428405752281 0.625 4.3 4 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.146004889869199 0.226817640047893 1.01428405752281 0.625 4.3 4 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.146004889869199 0.226817640047893 1.01428405752281 0.625 4.3 4 3 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.146004889869199 0.226817640047893 1.01428405752281 0.625 4.3 4 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.146004889869199 0.226817640047893 1.01428405752281 0.625 4.3 4 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.146004889869199 0.226817640047893 1.01428405752281 0.625 4.3 4 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.25671396718835e-43 3.86191997942418e-41 1.00986848031976 0.622279129321383 4.3 4 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.42208861183915e-05 5.05908023661777e-05 1.00658063430112 0.620253164556962 4.3 4 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.58972986123525e-14 1.71377696404376e-13 1.00462420935592 0.619047619047619 4.3 4 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.58972986123525e-14 1.71377696404376e-13 1.00462420935592 0.619047619047619 4.3 4 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.58972986123525e-14 1.71377696404376e-13 1.00462420935592 0.619047619047619 4.3 4 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0232605963510079 0.0450951343426216 1.00462420935592 0.619047619047619 4.3 4 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00440821021747671 0.0100688332896779 1.00235130390489 0.617647058823529 4.3 4 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00440821021747671 0.0100688332896779 1.00235130390489 0.617647058823529 4.3 4 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0751236000658298 0.126211195860302 0.998679687407073 0.615384615384615 4.3 4 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0751236000658298 0.126211195860302 0.998679687407073 0.615384615384615 4.3 4 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0751236000658298 0.126211195860302 0.998679687407073 0.615384615384615 4.3 4 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.4348809830324e-07 6.67266548645459e-07 0.994652753183657 0.612903225806452 4.3 4 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0406479257000197 0.0742516024019615 0.991744411800079 0.611111111111111 4.3 4 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.000179764762969463 0.000543110950542559 0.988926956084738 0.609375 4.3 4 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 4.06381278418566e-09 2.23274347177459e-08 0.987824473413517 0.608695652173913 4.3 4 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0225962674299733 0.0441076660532949 0.987824473413517 0.608695652173913 4.3 4 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0225962674299733 0.0441076660532949 0.987824473413517 0.608695652173913 4.3 4 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0225962674299733 0.0441076660532949 0.987824473413517 0.608695652173913 4.3 4 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 4.00542943343645e-09 2.2091961565039e-08 0.985660090255293 0.607361963190184 4.3 4 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00731083051212806 0.016229815629888 0.983548176991814 0.606060606060606 4.3 4 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00731083051212806 0.016229815629888 0.983548176991814 0.606060606060606 4.3 4 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00731083051212806 0.016229815629888 0.983548176991814 0.606060606060606 4.3 4 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00421943568595582 0.0096842854534115 0.982254034653667 0.605263157894737 4.3 4 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 6.43879546619175e-09 3.47060831378442e-08 0.981726791478866 0.604938271604938 4.3 4 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 6.04923818849083e-07 2.55432223804821e-06 0.979077503460033 0.603305785123967 4.3 4 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0041010986230926 0.00942788908022742 0.973712695221896 0.6 4.3 4 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0390458811131804 0.0718847317121403 0.973712695221896 0.6 4.3 4 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0390458811131804 0.0718847317121403 0.973712695221896 0.6 4.3 4 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.136598510066174 0.220135537739712 0.973712695221896 0.6 4.3 4 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.136598510066174 0.220135537739712 0.973712695221896 0.6 4.3 4 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.136598510066174 0.220135537739712 0.973712695221896 0.6 4.3 4 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.136598510066174 0.220135537739712 0.973712695221896 0.6 4.3 4 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00139466649352223 0.00357587463113897 0.973712695221896 0.6 4.3 4 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0218108816855025 0.0427505298050552 0.973712695221896 0.6 4.3 4 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 5.67258462128358e-07 2.40957848241389e-06 0.971157018856484 0.598425196850394 4.3 4 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.98271256350384e-68 9.44566662977661e-66 0.965959871954581 0.595222724338283 4.3 4 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.89950165805678e-07 8.74754323435211e-07 0.964633788972741 0.594405594405594 4.3 4 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.41004910155659e-25 1.4704545065197e-23 0.963481038179284 0.59369527145359 4.3 4 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0209493466421043 0.0418657614066174 0.96169155083644 0.592592592592593 4.3 4 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00660680804566081 0.0148054926755517 0.957068033765111 0.58974358974359 4.3 4 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.63125350458389e-19 6.56890129302259e-18 0.956974734093268 0.589686098654709 4.3 4 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0677526070976981 0.116721501089618 0.954620289433231 0.588235294117647 4.3 4 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0677526070976981 0.116721501089618 0.954620289433231 0.588235294117647 4.3 4 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 1.59641649639398e-07 7.38419985943047e-07 0.952772637260135 0.587096774193548 4.3 4 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.04796083708685e-08 5.58519951750783e-08 0.946665120354621 0.583333333333333 4.3 4 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.12716166537448 0.206565125374298 0.946665120354621 0.583333333333333 4.3 4 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0638938712660874 0.110475065384742 0.939547337494812 0.578947368421053 4.3 4 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0638938712660874 0.110475065384742 0.939547337494812 0.578947368421053 4.3 4 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 3.44932048459387e-07 1.53386970299284e-06 0.939010146335581 0.578616352201258 4.3 4 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 3.44932048459387e-07 1.53386970299284e-06 0.939010146335581 0.578616352201258 4.3 4 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0336555908439675 0.0627678974717769 0.936262206944131 0.576923076923077 4.3 4 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.0336555908439675 0.0627678974717769 0.936262206944131 0.576923076923077 4.3 4 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.0336555908439675 0.0627678974717769 0.936262206944131 0.576923076923077 4.3 4 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.08638355157554e-07 2.18668392564713e-06 0.933141332920984 0.575 4.3 4 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0318453530703637 0.060663905514227 0.927345424020853 0.571428571428571 4.3 4 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0318453530703637 0.060663905514227 0.927345424020853 0.571428571428571 4.3 4 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.118103994397974 0.192070838889504 0.927345424020853 0.571428571428571 4.3 4 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.118103994397974 0.192070838889504 0.927345424020853 0.571428571428571 4.3 4 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.118103994397974 0.192070838889504 0.927345424020853 0.571428571428571 4.3 4 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.118103994397974 0.192070838889504 0.927345424020853 0.571428571428571 4.3 4 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000952770613681484 0.00253419174442757 0.927345424020853 0.571428571428571 4.3 4 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 9.85619206133132e-14 9.60641185155785e-13 0.924246007496719 0.56951871657754 4.3 4 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0163765024879414 0.0335305943026484 0.921079576561253 0.567567567567568 4.3 4 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.030077396839685 0.0574498465810358 0.919617545487346 0.566666666666667 4.3 4 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0564127818942414 0.0980163475402998 0.917265582455409 0.565217391304348 4.3 4 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0564127818942414 0.0980163475402998 0.917265582455409 0.565217391304348 4.3 4 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0283667442609906 0.0543282329520722 0.912855651770527 0.5625 4.3 4 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0283667442609906 0.0543282329520722 0.912855651770527 0.5625 4.3 4 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.109579364733428 0.179231535650194 0.912855651770527 0.5625 4.3 4 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.109579364733428 0.179231535650194 0.912855651770527 0.5625 4.3 4 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00040893886308052 0.00119736625959584 0.911716006762075 0.561797752808989 4.3 4 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 4.00012904627579e-06 1.50986303258633e-05 0.910892521336612 0.561290322580645 4.3 4 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0138487055064574 0.0287269794980887 0.905779251369205 0.558139534883721 4.3 4 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.101633458844796 0.16681016370951 0.901585828909163 0.555555555555556 4.3 4 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.228656159629184 0.336481608223711 0.901585828909163 0.555555555555556 4.3 4 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.228656159629184 0.336481608223711 0.901585828909163 0.555555555555556 4.3 4 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.228656159629184 0.336481608223711 0.901585828909163 0.555555555555556 4.3 4 3 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.228656159629184 0.336481608223711 0.901585828909163 0.555555555555556 4.3 4 3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.228656159629184 0.336481608223711 0.901585828909163 0.555555555555556 4.3 4 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.228656159629184 0.336481608223711 0.901585828909163 0.555555555555556 4.3 4 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0495383960962964 0.0884481024404389 0.901585828909163 0.555555555555556 4.3 4 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 3.64930806311176e-05 0.000121900595629297 0.892569970620071 0.55 4.3 4 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0942636370085294 0.155071856026748 0.892569970620071 0.55 4.3 4 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 3.46080819513242e-05 0.000116423878526559 0.891427115343989 0.549295774647887 4.3 4 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 5.63246884810015e-05 0.000184677492415818 0.888423991990781 0.547445255474453 4.3 4 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0196159042415609 0.0397627232702865 0.885193359292633 0.545454545454545 4.3 4 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.206788599775448 0.306840643879523 0.885193359292633 0.545454545454545 4.3 4 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.206788599775448 0.306840643879523 0.885193359292633 0.545454545454545 4.3 4 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.206788599775448 0.306840643879523 0.885193359292633 0.545454545454545 4.3 4 3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.206788599775448 0.306840643879523 0.885193359292633 0.545454545454545 4.3 4 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.206788599775448 0.306840643879523 0.885193359292633 0.545454545454545 4.3 4 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.206788599775448 0.306840643879523 0.885193359292633 0.545454545454545 4.3 4 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0405762393783711 0.0742159236959153 0.885193359292632 0.545454545454545 4.3 4 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0405762393783711 0.0742159236959153 0.885193359292632 0.545454545454545 4.3 4 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0405762393783711 0.0742159236959153 0.885193359292632 0.545454545454545 4.3 4 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 8.20036950035027e-05 0.000260471558013358 0.883023767725739 0.544117647058823 4.3 4 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00113152533198261 0.00295442302277294 0.881986136976355 0.543478260869565 4.3 4 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0379422926303148 0.0705776240692 0.88097815281981 0.542857142857143 4.3 4 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.00408255724281891 0.00940045138597299 0.879046183186434 0.541666666666667 4.3 4 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0172838849994575 0.0352868986430817 0.879046183186434 0.541666666666667 4.3 4 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0172838849994575 0.0352868986430817 0.879046183186434 0.541666666666667 4.3 4 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00196239588182189 0.00485650319970879 0.878250666278573 0.541176470588235 4.3 4 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00196239588182189 0.00485650319970879 0.878250666278573 0.541176470588235 4.3 4 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00196239588182189 0.00485650319970879 0.878250666278573 0.541176470588235 4.3 4 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00196239588182189 0.00485650319970879 0.878250666278573 0.541176470588235 4.3 4 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00196239588182189 0.00485650319970879 0.878250666278573 0.541176470588235 4.3 4 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.000112166337585486 0.000353125438902981 0.876578338764237 0.54014598540146 4.3 4 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0753270562033677 0.126403774737491 0.873844726481189 0.538461538461538 4.3 4 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.187872741567905 0.281710127767259 0.873844726481189 0.538461538461538 4.3 4 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.187872741567905 0.281710127767259 0.873844726481189 0.538461538461538 4.3 4 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.187872741567905 0.281710127767259 0.873844726481189 0.538461538461538 4.3 4 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.187872741567905 0.281710127767259 0.873844726481189 0.538461538461538 4.3 4 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.187872741567905 0.281710127767259 0.873844726481189 0.538461538461538 4.3 4 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.187872741567905 0.281710127767259 0.873844726481189 0.538461538461538 4.3 4 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0331640683637508 0.0620953543179176 0.873844726481188 0.538461538461538 4.3 4 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000669502072017386 0.00181813253526859 0.870440136637755 0.536363636363636 4.3 4 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0699534457416039 0.120367295393352 0.86938633501955 0.535714285714286 4.3 4 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00251679654202004 0.00612205381075987 0.866751830974036 0.534090909090909 4.3 4 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.58046584663188e-06 1.00054574925263e-05 0.86600755404638 0.533632286995516 4.3 4 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00236772636618604 0.00584943510257419 0.865522395752796 0.533333333333333 4.3 4 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0649895499981804 0.112233167047828 0.865522395752796 0.533333333333333 4.3 4 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.171297777628035 0.258765114187574 0.865522395752796 0.533333333333333 4.3 4 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00434453731991851 0.00995535685385513 0.861515347624311 0.530864197530864 4.3 4 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00011982222147219 0.000373918906041504 0.857942183688082 0.528662420382166 4.3 4 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.14356633393225 0.226817640047893 0.854133943177102 0.526315789473684 4.3 4 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.14356633393225 0.226817640047893 0.854133943177102 0.526315789473684 4.3 4 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0276370162482553 0.0530735143336941 0.841480106981885 0.518518518518518 4.3 4 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0519413314191813 0.0926221987587657 0.82945896259643 0.511111111111111 4.3 4 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0362147897011374 0.0674524158962285 0.826180468673124 0.509090909090909 4.3 4 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0624908194874061 0.108312346078659 0.811427246018247 0.5 4.3 4 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0986658716145505 0.162126484188805 0.811427246018247 0.5 4.3 4 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.136245473049592 0.220135537739712 0.811427246018247 0.5 4.3 4 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.192869030855972 0.288290578684924 0.811427246018247 0.5 4.3 4 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.192869030855972 0.288290578684924 0.811427246018247 0.5 4.3 4 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.211635475302454 0.313705501411867 0.811427246018247 0.5 4.3 4 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.257641488737836 0.376024449716862 0.811427246018247 0.5 4.3 4 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.257641488737836 0.376024449716862 0.811427246018247 0.5 4.3 4 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.286415534176416 0.409617392093507 0.811427246018247 0.5 4.3 4 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.286415534176416 0.409617392093507 0.811427246018247 0.5 4.3 4 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.286415534176416 0.409617392093507 0.811427246018247 0.5 4.3 4 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.286415534176416 0.409617392093507 0.811427246018247 0.5 4.3 4 3 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.320713809192193 0.453653827515398 0.811427246018247 0.5 4.3 4 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.320713809192193 0.453653827515398 0.811427246018247 0.5 4.3 4 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0580413993443004 0.100723062520658 0.811427246018246 0.5 4.3 4 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0782684923881197 0.130569829622854 0.811427246018246 0.5 4.3 4 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0793719757808709 0.131180396673844 0.794867506303588 0.489795918367347 4.3 4 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0389013885160763 0.0718847317121403 0.790073897438819 0.486842105263158 4.3 4 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.160533054379912 0.243019719555973 0.785252173566045 0.483870967741935 4.3 4 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.174534321109095 0.263374696647129 0.783446996155548 0.482758620689655 4.3 4 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.190054836288211 0.284682138987499 0.781374385054608 0.481481481481481 4.3 4 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.106783751916916 0.175061381310797 0.777617777434153 0.479166666666667 4.3 4 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000944014474452931 0.00251560411450659 0.776424502072361 0.47843137254902 4.3 4 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.0294525168667585 0.0563318971792976 0.772787853350711 0.476190476190476 4.3 4 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.134280917266484 0.21763296727814 0.772787853350711 0.476190476190476 4.3 4 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.272897702535637 0.397068947554408 0.768720548859391 0.473684210526316 4.3 4 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.272897702535637 0.397068947554408 0.768720548859391 0.473684210526316 4.3 4 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.8319522852962e-05 6.42085739403078e-05 0.767167578053615 0.472727272727273 4.3 4 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.112957221934079 0.184544347660384 0.765497401904006 0.471698113207547 4.3 4 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.300911055810659 0.427768663754813 0.763696231546585 0.470588235294118 4.3 4 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.300911055810659 0.427768663754813 0.763696231546585 0.470588235294118 4.3 4 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.333192235958912 0.463926175899737 0.757332096283697 0.466666666666667 4.3 4 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.23668961776168 0.347584443833716 0.753468157016943 0.464285714285714 4.3 4 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.23668961776168 0.347584443833716 0.753468157016943 0.464285714285714 4.3 4 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.258017277069917 0.376187075072226 0.749009765555305 0.461538461538462 4.3 4 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.370880784983711 0.510903540205054 0.749009765555305 0.461538461538462 4.3 4 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.281789460807592 0.409587745382231 0.743808308850059 0.458333333333333 4.3 4 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.308408150175544 0.43798882005968 0.73766113274386 0.454545454545455 4.3 4 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.415651483706148 0.550288986701724 0.73766113274386 0.454545454545455 4.3 4 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.415651483706148 0.550288986701724 0.73766113274386 0.454545454545455 4.3 4 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.415651483706148 0.550288986701724 0.73766113274386 0.454545454545455 4.3 4 3 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.415651483706148 0.550288986701724 0.73766113274386 0.454545454545455 4.3 4 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.415651483706148 0.550288986701724 0.73766113274386 0.454545454545455 4.3 4 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.415651483706148 0.550288986701724 0.73766113274386 0.454545454545455 4.3 4 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.415651483706148 0.550288986701724 0.73766113274386 0.454545454545455 4.3 4 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.243666942851635 0.357461917193687 0.73766113274386 0.454545454545455 4.3 4 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.338375706637181 0.470682923308611 0.730284521416422 0.45 4.3 4 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.287190796291906 0.410313758156006 0.727486496430152 0.448275862068966 4.3 4 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.372331520217222 0.512405950937241 0.72126866312733 0.444444444444444 4.3 4 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.312387229695283 0.443197435549739 0.72126866312733 0.444444444444444 4.3 4 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.290471723685146 0.414585017857535 0.715965217074923 0.441176470588235 4.3 4 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.34029601031065 0.471333127847984 0.714055976496057 0.44 4.3 4 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.34029601031065 0.471333127847984 0.714055976496057 0.44 4.3 4 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.34029601031065 0.471333127847984 0.714055976496057 0.44 4.3 4 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.34029601031065 0.471333127847984 0.714055976496057 0.44 4.3 4 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.411106937964898 0.550288986701724 0.709998840265966 0.4375 4.3 4 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.411106937964898 0.550288986701724 0.709998840265966 0.4375 4.3 4 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.160731674871764 0.243061820767821 0.707840789079747 0.436170212765957 4.3 4 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.340499265936562 0.471333127847984 0.703236946549147 0.433333333333333 4.3 4 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.133206787474866 0.216138265195821 0.702811000488245 0.433070866141732 4.3 4 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.315077989950796 0.446569700896397 0.70177491547524 0.432432432432432 4.3 4 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.193177565967603 0.288448768490975 0.698001932058707 0.43010752688172 4.3 4 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.455810257168117 0.600572218472435 0.69550906801564 0.428571428571429 4.3 4 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.293620194194449 0.418239776114815 0.69550906801564 0.428571428571429 4.3 4 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.405902795281898 0.545419903386346 0.69550906801564 0.428571428571429 4.3 4 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.138173741300589 0.222422210261015 0.688769639062 0.424418604651163 4.3 4 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.366442548674275 0.50527882438323 0.68848372389427 0.424242424242424 4.3 4 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.40063374802052 0.538848604379206 0.686592285092362 0.423076923076923 4.3 4 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.145302251126172 0.226817640047893 0.684230542588359 0.421621621621622 4.3 4 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.290978841173883 0.414892676343122 0.682069279261714 0.420289855072464 4.3 4 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.395476475956889 0.532415350318499 0.680551883757239 0.419354838709677 4.3 4 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.395476475956889 0.532415350318499 0.680551883757239 0.419354838709677 4.3 4 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.227414335329512 0.336481608223711 0.678406386015255 0.418032786885246 4.3 4 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.507962876227385 0.655331979031341 0.676189371681872 0.416666666666667 4.3 4 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.507962876227385 0.655331979031341 0.676189371681872 0.416666666666667 4.3 4 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.507962876227385 0.655331979031341 0.676189371681872 0.416666666666667 4.3 4 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.381042016515418 0.515231409956875 0.67030946410203 0.41304347826087 4.3 4 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.488244055472866 0.636723389620301 0.668234202603262 0.411764705882353 4.3 4 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.331770272928874 0.462398725149646 0.663895019469474 0.409090909090909 4.3 4 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.385072803908346 0.51988481969789 0.659284637389825 0.40625 4.3 4 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.450980008754276 0.594758621369171 0.659284637389825 0.40625 4.3 4 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.390403712312277 0.526582447981394 0.649141796814597 0.4 4.3 4 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.484702760475252 0.635112364784792 0.649141796814597 0.4 4.3 4 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.520925035131472 0.670838303160258 0.637549979014337 0.392857142857143 4.3 4 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.562006577908276 0.717251444272176 0.631110080236414 0.388888888888889 4.3 4 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.510281161222359 0.657726532988602 0.628201738852836 0.387096774193548 4.3 4 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.559762042569797 0.71502817466501 0.62417480462942 0.384615384615385 4.3 4 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.593639183254682 0.748890565400189 0.62417480462942 0.384615384615385 4.3 4 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.593639183254682 0.748890565400189 0.62417480462942 0.384615384615385 4.3 4 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.593639183254682 0.748890565400189 0.62417480462942 0.384615384615385 4.3 4 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.54321756661534 0.695142623465494 0.62417480462942 0.384615384615385 4.3 4 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.54321756661534 0.695142623465494 0.62417480462942 0.384615384615385 4.3 4 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.553531070155076 0.707704144501952 0.616273857735377 0.379746835443038 4.3 4 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.572557695549553 0.726806066696712 0.612643864463576 0.377510040160643 4.3 4 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.574932149572305 0.728747118989261 0.612397921523205 0.377358490566038 4.3 4 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.575111043306353 0.728747118989261 0.61189595601376 0.377049180327869 4.3 4 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.57699078188199 0.729829228993842 0.610956985237268 0.376470588235294 4.3 4 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.57699078188199 0.729829228993842 0.610956985237268 0.376470588235294 4.3 4 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.613424804646533 0.762983684826981 0.608570434513685 0.375 4.3 4 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.613424804646533 0.762983684826981 0.608570434513685 0.375 4.3 4 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.7746270990622 0.907238157996304 0.606393434585343 0.373658536585366 4.3 4 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.625858546600438 0.768769126034349 0.603622707403817 0.371951219512195 4.3 4 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.617678991511371 0.762983684826981 0.601057219272775 0.37037037037037 4.3 4 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.630466317696476 0.768769126034349 0.597893760223971 0.368421052631579 4.3 4 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.632504632492851 0.770594256881273 0.595046647080047 0.366666666666667 4.3 4 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.646057669940899 0.781751755379166 0.590128906195088 0.363636363636364 4.3 4 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.66131758599715 0.798180597857459 0.586989922651498 0.361702127659574 4.3 4 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.675380895304964 0.813773932276854 0.585291784013161 0.360655737704918 4.3 4 3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.67021080885833 0.808228797462206 0.579590890013033 0.357142857142857 4.3 4 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.682801268532993 0.821323926561664 0.575851593948433 0.354838709677419 4.3 4 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.681705213286715 0.820699254236037 0.572772173659939 0.352941176470588 4.3 4 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.692374182441317 0.83213552501182 0.567999072212773 0.35 4.3 4 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.72044201936712 0.865138391189377 0.559604997253963 0.344827586206897 4.3 4 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.751187771802361 0.892270617090784 0.554145436305144 0.341463414634146 4.3 4 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.751187771802361 0.892270617090784 0.554145436305144 0.341463414634146 4.3 4 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.736538410967034 0.876332908700744 0.540951497345498 0.333333333333333 4.3 4 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.752846309515983 0.893494827724139 0.540951497345498 0.333333333333333 4.3 4 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.806777184054125 0.933369051145544 0.525041159188277 0.323529411764706 4.3 4 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.803272352933426 0.930070429800053 0.52350144904403 0.32258064516129 4.3 4 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.796971955256375 0.927768392865245 0.519313437451678 0.32 4.3 4 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.913943066912917 1 0.518644219104446 0.319587628865979 4.3 4 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.871680945637564 0.983989156114425 0.507142028761404 0.3125 4.3 4 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.792499141112717 0.925883643516746 0.507142028761404 0.3125 4.3 4 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.792499141112717 0.925883643516746 0.507142028761404 0.3125 4.3 4 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.792499141112717 0.925883643516746 0.507142028761404 0.3125 4.3 4 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.867658446256238 0.983023860686804 0.499339843703536 0.307692307692308 4.3 4 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.939513339728526 1 0.493019086188302 0.30379746835443 4.3 4 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.99673872046597 1 0.490038415242392 0.301960784313725 4.3 4 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.835876798993711 0.965464841694847 0.486856347610948 0.3 4.3 4 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.86631991439328 0.982289432814054 0.486856347610948 0.3 4.3 4 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.969579351343035 1 0.483735473587801 0.298076923076923 4.3 4 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.871390141192897 0.983989156114425 0.463672712010426 0.285714285714286 4.3 4 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.949399649264324 1 0.459298441142404 0.283018867924528 4.3 4 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.984628414454534 1 0.458989149262847 0.282828282828283 4.3 4 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.940677885423678 1 0.452889625684603 0.27906976744186 4.3 4 3 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.900227448004217 1 0.442596679646316 0.272727272727273 4.3 4 3 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.900227448004217 1 0.442596679646316 0.272727272727273 4.3 4 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.943707968893513 1 0.438609322172025 0.27027027027027 4.3 4 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.955427469157343 1 0.427066971588551 0.263157894736842 4.3 4 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.923315346353669 1 0.42335334574865 0.260869565217391 4.3 4 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.948503753092405 1 0.418801159235224 0.258064516129032 4.3 4 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.948503753092405 1 0.418801159235224 0.258064516129032 4.3 4 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999955875146614 1 0.418801159235224 0.258064516129032 4.3 4 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999998924004435 1 0.405713623009123 0.25 4.3 4 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999962976615722 1 0.401351110933756 0.247311827956989 4.3 4 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.989555298366673 1 0.398595840149314 0.245614035087719 4.3 4 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999996536443 1 0.397348393668729 0.244845360824742 4.3 4 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.955828562012816 1 0.389485078088758 0.24 4.3 4 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.996157165425072 1 0.388570793867893 0.23943661971831 4.3 4 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.960767778257379 1 0.36883056637193 0.227272727272727 4.3 4 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.978991977201612 1 0.366451014330821 0.225806451612903 4.3 4 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.993684101317394 1 0.364314273722478 0.224489795918367 4.3 4 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.997692975093159 1 0.360634331563665 0.222222222222222 4.3 4 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.993615726324067 1 0.324570898407299 0.2 4.3 4 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.303859405309939 0.187237615449202 4.3 4 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999997456048 1 0.295064453097544 0.181818181818182 4.3 4 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.998083427760975 1 0.278203627206256 0.171428571428571 4.3 4 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.250911499220832 0.154611211573237 4.3 4 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999976092338 1 0.24042288770911 0.148148148148148 4.3 4 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999916652649827 1 0.236666280088655 0.145833333333333 4.3 4 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999957034709 1 0.216380598938199 0.133333333333333 4.3 4 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 1.70166968623914e-05 7.40512527069816e-05 2.9446511627907 1 4.2 4 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 6.71657520635086e-05 0.000261854425168145 2.9446511627907 1 4.2 4 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 6.71657520635086e-05 0.000261854425168145 2.9446511627907 1 4.2 4 2 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00104611619945088 0.00327169967432661 2.9446511627907 1 4.2 4 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00104611619945088 0.00327169967432661 2.9446511627907 1 4.2 4 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00104611619945088 0.00327169967432661 2.9446511627907 1 4.2 4 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00104611619945088 0.00327169967432661 2.9446511627907 1 4.2 4 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 2.55728625138385e-08 2.04439232343776e-07 2.6174677002584 0.888888888888889 4.2 4 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000118663313525489 0.000445535343395173 2.6174677002584 0.888888888888889 4.2 4 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 9.00028111011124e-08 6.43587940687854e-07 2.59822161422709 0.882352941176471 4.2 4 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 9.00028111011124e-08 6.43587940687854e-07 2.59822161422709 0.882352941176471 4.2 4 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.64339469254267e-10 3.18839155300689e-09 2.57656976744186 0.875 4.2 4 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 3.14509148375406e-07 2.09133886980468e-06 2.57656976744186 0.875 4.2 4 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 3.14509148375406e-07 2.09133886980468e-06 2.57656976744186 0.875 4.2 4 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00041820913847133 0.00137439169525335 2.57656976744186 0.875 4.2 4 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00041820913847133 0.00137439169525335 2.57656976744186 0.875 4.2 4 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.00041820913847133 0.00137439169525335 2.57656976744186 0.875 4.2 4 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00041820913847133 0.00137439169525335 2.57656976744186 0.875 4.2 4 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.00041820913847133 0.00137439169525335 2.57656976744186 0.875 4.2 4 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00041820913847133 0.00137439169525335 2.57656976744186 0.875 4.2 4 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 1.09021553870493e-06 5.78871907304894e-06 2.55203100775194 0.866666666666667 4.2 4 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 1.09021553870493e-06 5.78871907304894e-06 2.55203100775194 0.866666666666667 4.2 4 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.07913842074952e-08 9.42094461795441e-08 2.52398671096346 0.857142857142857 4.2 4 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00145259029672188 0.00436083542665662 2.52398671096346 0.857142857142857 4.2 4 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 1.01339647317049e-13 1.98379575002179e-12 2.52398671096346 0.857142857142857 4.2 4 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 4.27333965478181e-05 0.000173741780821558 2.45387596899225 0.833333333333333 4.2 4 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 4.27333965478181e-05 0.000173741780821558 2.45387596899225 0.833333333333333 4.2 4 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 4.27333965478181e-05 0.000173741780821558 2.45387596899225 0.833333333333333 4.2 4 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 4.27333965478181e-05 0.000173741780821558 2.45387596899225 0.833333333333333 4.2 4 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00495127947591749 0.0126493190201626 2.45387596899225 0.833333333333333 4.2 4 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.34270415450551e-11 6.05849805084446e-10 2.45387596899225 0.833333333333333 4.2 4 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.36220538898877e-06 7.10043321806236e-06 2.42500683994528 0.823529411764706 4.2 4 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 4.51577517097149e-08 3.34684795223564e-07 2.4092600422833 0.818181818181818 4.2 4 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.000141437682431993 0.00051739285887076 2.4092600422833 0.818181818181818 4.2 4 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.000141437682431993 0.00051739285887076 2.4092600422833 0.818181818181818 4.2 4 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.000141437682431993 0.00051739285887076 2.4092600422833 0.818181818181818 4.2 4 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.000141437682431993 0.00051739285887076 2.4092600422833 0.818181818181818 4.2 4 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000141437682431993 0.00051739285887076 2.4092600422833 0.818181818181818 4.2 4 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.000141437682431993 0.00051739285887076 2.4092600422833 0.818181818181818 4.2 4 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000460193248124287 0.00149852400933835 2.35572093023256 0.8 4.2 4 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000460193248124287 0.00149852400933835 2.35572093023256 0.8 4.2 4 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 1.43624001321644e-05 6.30793067533025e-05 2.35572093023256 0.8 4.2 4 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.88278621859488e-10 2.35017963952677e-09 2.3200281888654 0.787878787878788 4.2 4 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 4.56642966128711e-05 0.000184080153201461 2.31365448504983 0.785714285714286 4.2 4 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 6.415282728018e-11 8.61221445468831e-10 2.2902842377261 0.777777777777778 4.2 4 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00146661952578177 0.00437526118487937 2.2902842377261 0.777777777777778 4.2 4 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00146661952578177 0.00437526118487937 2.2902842377261 0.777777777777778 4.2 4 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00146661952578177 0.00437526118487937 2.2902842377261 0.777777777777778 4.2 4 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000142753273881027 0.000520866432647951 2.26511627906977 0.769230769230769 4.2 4 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 1.50793854165554e-06 7.66355908848514e-06 2.24354374307863 0.761904761904762 4.2 4 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.50793854165554e-06 7.66355908848514e-06 2.24354374307863 0.761904761904762 4.2 4 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.50793854165554e-06 7.66355908848514e-06 2.24354374307863 0.761904761904762 4.2 4 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 4.8141378835025e-07 3.0312027470018e-06 2.20848837209302 0.75 4.2 4 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 4.40947708382591e-05 0.000178765979780179 2.20848837209302 0.75 4.2 4 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000437550540084516 0.00143134349089716 2.20848837209302 0.75 4.2 4 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00455573377147354 0.0119169285970714 2.20848837209302 0.75 4.2 4 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00455573377147354 0.0119169285970714 2.20848837209302 0.75 4.2 4 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00455573377147354 0.0119169285970714 2.20848837209302 0.75 4.2 4 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 1.6469079696756e-08 1.37049709991133e-07 2.18474118529632 0.741935483870968 4.2 4 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 4.85371708604656e-08 3.57867327121464e-07 2.15941085271318 0.733333333333333 4.2 4 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000131744511934815 0.000489484178807418 2.15941085271318 0.733333333333333 4.2 4 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000131744511934815 0.000489484178807418 2.15941085271318 0.733333333333333 4.2 4 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.000131744511934815 0.000489484178807418 2.15941085271318 0.733333333333333 4.2 4 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 4.5055587381091e-07 2.88802256050867e-06 2.15186046511628 0.730769230769231 4.2 4 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 6.50457732661641e-12 1.08894276891472e-10 2.14714147286822 0.729166666666667 4.2 4 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0013102080899704 0.00397532220048589 2.1415644820296 0.727272727272727 4.2 4 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0013102080899704 0.00397532220048589 2.1415644820296 0.727272727272727 4.2 4 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 1.30931441753034e-06 6.84983241230029e-06 2.1201488372093 0.72 4.2 4 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.30931441753034e-06 6.84983241230029e-06 2.1201488372093 0.72 4.2 4 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 1.22147594434159e-05 5.39801325713689e-05 2.10332225913621 0.714285714285714 4.2 4 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.000385475717051417 0.00129066340085686 2.10332225913621 0.714285714285714 4.2 4 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.000385475717051417 0.00129066340085686 2.10332225913621 0.714285714285714 4.2 4 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.000385475717051417 0.00129066340085686 2.10332225913621 0.714285714285714 4.2 4 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0136980024239065 0.0312375920660561 2.10332225913621 0.714285714285714 4.2 4 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0136980024239065 0.0312375920660561 2.10332225913621 0.714285714285714 4.2 4 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0136980024239065 0.0312375920660561 2.10332225913621 0.714285714285714 4.2 4 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0136980024239065 0.0312375920660561 2.10332225913621 0.714285714285714 4.2 4 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0136980024239065 0.0312375920660561 2.10332225913621 0.714285714285714 4.2 4 2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0136980024239065 0.0312375920660561 2.10332225913621 0.714285714285714 4.2 4 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 1.39615347435107e-08 1.19682312891661e-07 2.10332225913621 0.714285714285714 4.2 4 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.54100868020597e-10 1.94057995746291e-09 2.09397416020672 0.711111111111111 4.2 4 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 3.75134636777527e-06 1.76760459647159e-05 2.08579457364341 0.708333333333333 4.2 4 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 3.75134636777527e-06 1.76760459647159e-05 2.08579457364341 0.708333333333333 4.2 4 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 3.96355059177116e-08 2.95294894873841e-07 2.07857729138167 0.705882352941177 4.2 4 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 3.96355059177116e-08 2.95294894873841e-07 2.07857729138167 0.705882352941177 4.2 4 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 3.96355059177116e-08 2.95294894873841e-07 2.07857729138167 0.705882352941177 4.2 4 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.000115141001936838 0.000434603834896871 2.07857729138167 0.705882352941177 4.2 4 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.000115141001936838 0.000434603834896871 2.07857729138167 0.705882352941177 4.2 4 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 1.15714811884455e-06 6.12127053202899e-06 2.07216192937123 0.703703703703704 4.2 4 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.2398208397959e-08 1.06925154850277e-07 2.06921433060968 0.702702702702703 4.2 4 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 3.4766029916176e-05 0.000143397277016575 2.06125581395349 0.7 4.2 4 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 3.4766029916176e-05 0.000143397277016575 2.06125581395349 0.7 4.2 4 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 3.4766029916176e-05 0.000143397277016575 2.06125581395349 0.7 4.2 4 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 3.4766029916176e-05 0.000143397277016575 2.06125581395349 0.7 4.2 4 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 3.4766029916176e-05 0.000143397277016575 2.06125581395349 0.7 4.2 4 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00381494750698257 0.0102621366775732 2.06125581395349 0.7 4.2 4 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00381494750698257 0.0102621366775732 2.06125581395349 0.7 4.2 4 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00381494750698257 0.0102621366775732 2.06125581395349 0.7 4.2 4 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00381494750698257 0.0102621366775732 2.06125581395349 0.7 4.2 4 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00381494750698257 0.0102621366775732 2.06125581395349 0.7 4.2 4 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00381494750698257 0.0102621366775732 2.06125581395349 0.7 4.2 4 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00381494750698257 0.0102621366775732 2.06125581395349 0.7 4.2 4 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 3.58235910701436e-07 2.34916912870112e-06 2.06125581395349 0.7 4.2 4 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.46341026393635e-08 2.70793011295683e-07 2.04489664082687 0.694444444444444 4.2 4 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.81088409845788e-17 6.4422201802639e-16 2.04393433652531 0.694117647058824 4.2 4 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.81088409845788e-17 6.4422201802639e-16 2.04393433652531 0.694117647058824 4.2 4 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.81088409845788e-17 6.4422201802639e-16 2.04393433652531 0.694117647058824 4.2 4 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 3.24152114089905e-06 1.56362189271164e-05 2.03860465116279 0.692307692307692 4.2 4 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00110084438904237 0.00337608096036054 2.03860465116279 0.692307692307692 4.2 4 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00110084438904237 0.00337608096036054 2.03860465116279 0.692307692307692 4.2 4 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 3.3784116160898e-09 3.43391409263985e-08 2.03321151716501 0.69047619047619 4.2 4 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 3.3784116160898e-09 3.43391409263985e-08 2.03321151716501 0.69047619047619 4.2 4 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 9.97864875660863e-07 5.33820194761431e-06 2.0307939053729 0.689655172413793 4.2 4 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 3.31750867096295e-10 3.90149986676056e-09 2.0244476744186 0.6875 4.2 4 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.000324573942347236 0.00111026134605797 2.0244476744186 0.6875 4.2 4 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.000324573942347236 0.00111026134605797 2.0244476744186 0.6875 4.2 4 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000324573942347236 0.00111026134605797 2.0244476744186 0.6875 4.2 4 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.000324573942347236 0.00111026134605797 2.0244476744186 0.6875 4.2 4 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.6044037332476e-19 7.61022170803779e-18 2.0225886774724 0.686868686868687 4.2 4 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.18235724484668e-13 2.24332581255576e-12 2.02170079833391 0.686567164179104 4.2 4 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.18235724484668e-13 2.24332581255576e-12 2.02170079833391 0.686567164179104 4.2 4 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.34036101979446e-17 1.50642286126037e-15 2.02016765819362 0.686046511627907 4.2 4 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.18089150405252e-14 2.66731525439164e-13 2.01688435807582 0.684931506849315 4.2 4 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 2.97472737854764e-08 2.35168725537405e-07 2.01476132190942 0.684210526315789 4.2 4 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 2.93482173921919e-05 0.000122830921614968 2.00771670190275 0.681818181818182 4.2 4 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 2.93482173921919e-05 0.000122830921614968 2.00771670190275 0.681818181818182 4.2 4 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.01768861385517e-13 1.98379575002179e-12 2.00577687900236 0.681159420289855 4.2 4 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 8.94066426204578e-06 4.01342752204768e-05 2.00236279069767 0.68 4.2 4 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.01654205393917e-17 3.90956579123091e-16 1.99476369092273 0.67741935483871 4.2 4 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.6502888901793e-31 5.51446757560429e-29 1.99196990424077 0.676470588235294 4.2 4 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.60969318272613e-07 1.77683894689918e-06 1.99196990424077 0.676470588235294 4.2 4 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.2533711750896e-30 1.37195937088654e-28 1.98633273703041 0.674556213017751 4.2 4 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 8.66063721863503e-18 3.62473140062284e-16 1.98376499388005 0.673684210526316 4.2 4 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 7.67808788576783e-10 8.34039623011269e-09 1.983132415757 0.673469387755102 4.2 4 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 2.40656512028846e-10 2.97786275319172e-09 1.98197674418605 0.673076923076923 4.2 4 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 8.70302839764559e-20 4.4230033606606e-18 1.98144751141056 0.672897196261682 4.2 4 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 7.55283638351143e-11 1.0044566517511e-09 1.98094714587738 0.672727272727273 4.2 4 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 7.33960374575037e-15 1.68455744035529e-13 1.97552546364439 0.670886075949367 4.2 4 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 7.33960374575037e-15 1.68455744035529e-13 1.97552546364439 0.670886075949367 4.2 4 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7.33960374575037e-15 1.68455744035529e-13 1.97552546364439 0.670886075949367 4.2 4 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.31746493222044e-16 6.59550519709938e-15 1.97425475687104 0.670454545454545 4.2 4 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.35150454346769e-22 1.59342426921644e-20 1.97101650412603 0.669354838709677 4.2 4 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.35150454346769e-22 1.59342426921644e-20 1.97101650412603 0.669354838709677 4.2 4 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.35150454346769e-22 1.59342426921644e-20 1.97101650412603 0.669354838709677 4.2 4 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 7.02798361856099e-07 3.93990892743162e-06 1.9631007751938 0.666666666666667 4.2 4 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 2.42450412204977e-05 0.000102375945569045 1.9631007751938 0.666666666666667 4.2 4 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 2.42450412204977e-05 0.000102375945569045 1.9631007751938 0.666666666666667 4.2 4 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 7.98685708616965e-05 0.000308839609609223 1.9631007751938 0.666666666666667 4.2 4 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00026545377868964 0.000923571459841949 1.9631007751938 0.666666666666667 4.2 4 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00305552318974218 0.00847565204484041 1.9631007751938 0.666666666666667 4.2 4 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00305552318974218 0.00847565204484041 1.9631007751938 0.666666666666667 4.2 4 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00305552318974218 0.00847565204484041 1.9631007751938 0.666666666666667 4.2 4 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00305552318974218 0.00847565204484041 1.9631007751938 0.666666666666667 4.2 4 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0107339622628571 0.0252469889256952 1.9631007751938 0.666666666666667 4.2 4 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0107339622628571 0.0252469889256952 1.9631007751938 0.666666666666667 4.2 4 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0107339622628571 0.0252469889256952 1.9631007751938 0.666666666666667 4.2 4 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0107339622628571 0.0252469889256952 1.9631007751938 0.666666666666667 4.2 4 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0107339622628571 0.0252469889256952 1.9631007751938 0.666666666666667 4.2 4 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 6.21737778231e-20 3.27678836452857e-18 1.9631007751938 0.666666666666667 4.2 4 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 6.17483981684552e-16 1.72290138419043e-14 1.9631007751938 0.666666666666667 4.2 4 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 6.18085399681419e-15 1.49073817584179e-13 1.9631007751938 0.666666666666667 4.2 4 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 6.18085399681419e-15 1.49073817584179e-13 1.9631007751938 0.666666666666667 4.2 4 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.19731729613994e-14 1.25982607320102e-12 1.9631007751938 0.666666666666667 4.2 4 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.19731729613994e-14 1.25982607320102e-12 1.9631007751938 0.666666666666667 4.2 4 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.19731729613994e-14 1.25982607320102e-12 1.9631007751938 0.666666666666667 4.2 4 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.19731729613994e-14 1.25982607320102e-12 1.9631007751938 0.666666666666667 4.2 4 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.19731729613994e-14 1.25982607320102e-12 1.9631007751938 0.666666666666667 4.2 4 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.99372750587046e-11 2.8949737151568e-10 1.9631007751938 0.666666666666667 4.2 4 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.99372750587046e-11 2.8949737151568e-10 1.9631007751938 0.666666666666667 4.2 4 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.99372750587046e-11 2.8949737151568e-10 1.9631007751938 0.666666666666667 4.2 4 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.99372750587046e-11 2.8949737151568e-10 1.9631007751938 0.666666666666667 4.2 4 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.99372750587046e-11 2.8949737151568e-10 1.9631007751938 0.666666666666667 4.2 4 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.99372750587046e-11 2.8949737151568e-10 1.9631007751938 0.666666666666667 4.2 4 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.99372750587046e-11 2.8949737151568e-10 1.9631007751938 0.666666666666667 4.2 4 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 7.41026718500806e-06 3.35821981027595e-05 1.9631007751938 0.666666666666667 4.2 4 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000892938127284621 0.00282995758379959 1.9631007751938 0.666666666666667 4.2 4 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 5.17922827065194e-17 1.71396321607854e-15 1.95276866585067 0.663157894736842 4.2 4 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 5.17922827065194e-17 1.71396321607854e-15 1.95276866585067 0.663157894736842 4.2 4 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.51519350615279e-28 4.01570022453464e-26 1.9510572121558 0.662576687116564 4.2 4 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 5.35257730667064e-10 6.09337400591386e-09 1.94458095655989 0.660377358490566 4.2 4 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 1.7944274485411e-07 1.25170110748725e-06 1.93727050183599 0.657894736842105 4.2 4 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.14213514156512e-18 4.92502517105203e-17 1.93583548664944 0.657407407407407 4.2 4 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 5.7782857916376e-07 3.36723398321771e-06 1.93505647840532 0.657142857142857 4.2 4 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 9.41660296897317e-18 3.72217389579134e-16 1.9253488372093 0.653846153846154 4.2 4 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 9.41660296897317e-18 3.72217389579134e-16 1.9253488372093 0.653846153846154 4.2 4 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.97057123797673e-05 8.44615322783401e-05 1.9253488372093 0.653846153846154 4.2 4 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.97057123797673e-05 8.44615322783401e-05 1.9253488372093 0.653846153846154 4.2 4 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.43012386067506e-08 1.21860254715007e-07 1.92042467138524 0.652173913043478 4.2 4 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 6.45337912800219e-05 0.00025367841157865 1.92042467138524 0.652173913043478 4.2 4 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.74956799073834e-47 1.63632705016413e-44 1.91955075799667 0.651877133105802 4.2 4 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.10478440663084e-42 1.44430117294795e-39 1.91797202174107 0.651340996168582 4.2 4 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.59099566204925e-11 5.05939289811493e-10 1.91636028054633 0.650793650793651 4.2 4 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.46452800619985e-07 1.0368275387176e-06 1.91402325581395 0.65 4.2 4 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00021284411868023 0.00075342582308947 1.91402325581395 0.65 4.2 4 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00021284411868023 0.00075342582308947 1.91402325581395 0.65 4.2 4 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.40736333846626e-14 5.35262192287106e-13 1.90536251709986 0.647058823529412 4.2 4 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.65550256851496e-09 3.68920578368567e-08 1.90536251709986 0.647058823529412 4.2 4 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000708534333099635 0.00228109582805607 1.90536251709986 0.647058823529412 4.2 4 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.000708534333099635 0.00228109582805607 1.90536251709986 0.647058823529412 4.2 4 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000708534333099635 0.00228109582805607 1.90536251709986 0.647058823529412 4.2 4 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 4.4055151626492e-21 2.72567307671731e-19 1.9026976744186 0.646153846153846 4.2 4 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 1.58161991697817e-05 6.90381945355808e-05 1.89299003322259 0.642857142857143 4.2 4 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00238850799862608 0.00678711779681114 1.89299003322259 0.642857142857143 4.2 4 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00238850799862608 0.00678711779681114 1.89299003322259 0.642857142857143 4.2 4 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00238850799862608 0.00678711779681114 1.89299003322259 0.642857142857143 4.2 4 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00238850799862608 0.00678711779681114 1.89299003322259 0.642857142857143 4.2 4 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 7.54765468868073e-12 1.24887356069682e-10 1.89299003322259 0.642857142857143 4.2 4 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.11889228516554e-19 5.49028869582955e-18 1.89128001512573 0.642276422764228 4.2 4 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 9.41103609286467e-09 8.26660762972002e-08 1.88457674418605 0.64 4.2 4 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 8.97421566108769e-19 3.99072152678993e-17 1.88061754934532 0.638655462184874 4.2 4 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 2.99202507321347e-08 2.35229374540485e-07 1.87956457199406 0.638297872340426 4.2 4 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 7.54280251586192e-10 8.25646767697808e-09 1.87848436246993 0.637931034482759 4.2 4 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 7.54280251586192e-10 8.25646767697808e-09 1.87848436246993 0.637931034482759 4.2 4 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.98140786916441e-13 9.08787615105251e-12 1.87721511627907 0.6375 4.2 4 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000168279189433329 0.000606231105224374 1.8738689217759 0.636363636363636 4.2 4 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00819824148675386 0.019694723481277 1.8738689217759 0.636363636363636 4.2 4 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.03462713650823e-07 2.03692189398642e-06 1.86733976176971 0.634146341463415 4.2 4 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.03462713650823e-07 2.03692189398642e-06 1.86733976176971 0.634146341463415 4.2 4 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.03462713650823e-07 2.03692189398642e-06 1.86733976176971 0.634146341463415 4.2 4 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.97883012507471e-62 1.41546881699533e-59 1.86632820176875 0.633802816901408 4.2 4 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.25693546617839e-05 5.5375206451141e-05 1.86494573643411 0.633333333333333 4.2 4 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.84210430253391e-76 2.02215721125288e-73 1.86419931028384 0.633079847908745 4.2 4 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 7.01993096386409e-17 2.27030949126787e-15 1.86404523149136 0.63302752293578 4.2 4 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 2.39723948589336e-08 1.92727219685099e-07 1.86294257237779 0.63265306122449 4.2 4 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00055407163761429 0.00180010032037702 1.85977968176255 0.631578947368421 4.2 4 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 7.60374295744039e-08 5.49244986215111e-07 1.8564105156724 0.630434782608696 4.2 4 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.80773463164902e-19 1.74787302607631e-17 1.85489837026186 0.62992125984252 4.2 4 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 6.04639539089524e-09 5.93380733878892e-08 1.85403962101637 0.62962962962963 4.2 4 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 2.41372575829157e-07 1.65929070243908e-06 1.84896700919416 0.627906976744186 4.2 4 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.56832792207709e-32 4.61611875737791e-30 1.84865992282824 0.62780269058296 4.2 4 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 5.40353854142817e-15 1.34898865692145e-13 1.8441249706366 0.626262626262626 4.2 4 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 7.66875412064522e-07 4.26274887253053e-06 1.84040697674419 0.625 4.2 4 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 7.66875412064522e-07 4.26274887253053e-06 1.84040697674419 0.625 4.2 4 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 9.91016919853561e-06 4.43464489607427e-05 1.84040697674419 0.625 4.2 4 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00184021176884693 0.00538810976763206 1.84040697674419 0.625 4.2 4 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00184021176884693 0.00538810976763206 1.84040697674419 0.625 4.2 4 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00184021176884693 0.00538810976763206 1.84040697674419 0.625 4.2 4 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00184021176884693 0.00538810976763206 1.84040697674419 0.625 4.2 4 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00184021176884693 0.00538810976763206 1.84040697674419 0.625 4.2 4 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00184021176884693 0.00538810976763206 1.84040697674419 0.625 4.2 4 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0289351168446282 0.0614547332386655 1.84040697674419 0.625 4.2 4 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0289351168446282 0.0614547332386655 1.84040697674419 0.625 4.2 4 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0289351168446282 0.0614547332386655 1.84040697674419 0.625 4.2 4 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0289351168446282 0.0614547332386655 1.84040697674419 0.625 4.2 4 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0289351168446282 0.0614547332386655 1.84040697674419 0.625 4.2 4 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0289351168446282 0.0614547332386655 1.84040697674419 0.625 4.2 4 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0289351168446282 0.0614547332386655 1.84040697674419 0.625 4.2 4 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0289351168446282 0.0614547332386655 1.84040697674419 0.625 4.2 4 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 6.03990115749217e-07 3.45171861329773e-06 1.82287929125138 0.619047619047619 4.2 4 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000428929383885346 0.00140637445453651 1.82287929125138 0.619047619047619 4.2 4 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.96859681547662e-11 2.8949737151568e-10 1.82103427172583 0.618421052631579 4.2 4 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.1969889117121e-08 1.03860684229654e-07 1.82032980972516 0.618181818181818 4.2 4 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 7.76340887190356e-06 3.50708915070437e-05 1.81875512995896 0.617647058823529 4.2 4 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.16380611050678e-15 5.80961527405876e-14 1.81632688545968 0.616822429906542 4.2 4 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 6.14206631370177e-11 8.40400035038233e-10 1.81519592226824 0.616438356164384 4.2 4 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 3.75706510233662e-08 2.85898590407754e-07 1.81209302325581 0.615384615384615 4.2 4 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000102248198640289 0.000391126845874007 1.81209302325581 0.615384615384615 4.2 4 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000102248198640289 0.000391126845874007 1.81209302325581 0.615384615384615 4.2 4 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000102248198640289 0.000391126845874007 1.81209302325581 0.615384615384615 4.2 4 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00618300927086187 0.015301603812933 1.81209302325581 0.615384615384615 4.2 4 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00618300927086187 0.015301603812933 1.81209302325581 0.615384615384615 4.2 4 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00618300927086187 0.015301603812933 1.81209302325581 0.615384615384615 4.2 4 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00618300927086187 0.015301603812933 1.81209302325581 0.615384615384615 4.2 4 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.00774356085794e-28 1.90467939140057e-26 1.80885714285714 0.614285714285714 4.2 4 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 4.73483510558851e-07 2.99796234919135e-06 1.80694503171247 0.613636363636364 4.2 4 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 4.73483510558851e-07 2.99796234919135e-06 1.80694503171247 0.613636363636364 4.2 4 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 5.96723954000859e-10 6.73919195669225e-09 1.80195071155849 0.611940298507463 4.2 4 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.50639912921731e-10 1.9139338936395e-09 1.79950904392765 0.611111111111111 4.2 4 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.50639912921731e-10 1.9139338936395e-09 1.79950904392765 0.611111111111111 4.2 4 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00140480377574391 0.00423524528153303 1.79950904392765 0.611111111111111 4.2 4 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00140480377574391 0.00423524528153303 1.79950904392765 0.611111111111111 4.2 4 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.09224806972677e-14 1.11481061588018e-12 1.79623720930233 0.61 4.2 4 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 9.64360052733168e-12 1.57733833912563e-10 1.79551900170164 0.609756097560976 4.2 4 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.49095775333594e-06 7.65932448735392e-06 1.79551900170164 0.609756097560976 4.2 4 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.49095775333594e-06 7.65932448735392e-06 1.79551900170164 0.609756097560976 4.2 4 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.49095775333594e-06 7.65932448735392e-06 1.79551900170164 0.609756097560976 4.2 4 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.49095775333594e-06 7.65932448735392e-06 1.79551900170164 0.609756097560976 4.2 4 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 4.68140349629777e-10 5.37228804454171e-09 1.79239635995956 0.608695652173913 4.2 4 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 3.69683251628982e-07 2.41311590398184e-06 1.79239635995956 0.608695652173913 4.2 4 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00032966091989403 0.00112495800721632 1.79239635995956 0.608695652173913 4.2 4 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 7.89225229107035e-05 0.000306012943057033 1.78782392026578 0.607142857142857 4.2 4 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 1.91523526210931e-05 8.2587265999441e-05 1.784637068358 0.606060606060606 4.2 4 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.66335642738986e-10 4.27291491489818e-09 1.78338028169014 0.605633802816901 4.2 4 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.79531765709819e-08 1.48531222444809e-07 1.77694466720128 0.603448275862069 4.2 4 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.86007050526121e-10 3.39156694082225e-09 1.77485823510672 0.602739726027397 4.2 4 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00106591291601538 0.00328310406815992 1.76679069767442 0.6 4.2 4 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00106591291601538 0.00328310406815992 1.76679069767442 0.6 4.2 4 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00106591291601538 0.00328310406815992 1.76679069767442 0.6 4.2 4 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00106591291601538 0.00328310406815992 1.76679069767442 0.6 4.2 4 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0211124843966688 0.0460672351742202 1.76679069767442 0.6 4.2 4 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0211124843966688 0.0460672351742202 1.76679069767442 0.6 4.2 4 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0211124843966688 0.0460672351742202 1.76679069767442 0.6 4.2 4 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0211124843966688 0.0460672351742202 1.76679069767442 0.6 4.2 4 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0211124843966688 0.0460672351742202 1.76679069767442 0.6 4.2 4 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0211124843966688 0.0460672351742202 1.76679069767442 0.6 4.2 4 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.47658593851472e-05 6.46517474001985e-05 1.76679069767442 0.6 4.2 4 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.000252025036394787 0.000881158788181281 1.76679069767442 0.6 4.2 4 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000252025036394787 0.000881158788181281 1.76679069767442 0.6 4.2 4 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000252025036394787 0.000881158788181281 1.76679069767442 0.6 4.2 4 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00463186280563827 0.0120276291467578 1.76679069767442 0.6 4.2 4 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00463186280563827 0.0120276291467578 1.76679069767442 0.6 4.2 4 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00463186280563827 0.0120276291467578 1.76679069767442 0.6 4.2 4 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00463186280563827 0.0120276291467578 1.76679069767442 0.6 4.2 4 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.10941987425358e-11 1.75411609006983e-10 1.76002138465651 0.597701149425287 4.2 4 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.10941987425358e-11 1.75411609006983e-10 1.76002138465651 0.597701149425287 4.2 4 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 6.86160345571477e-10 7.6281732167829e-09 1.75861111111111 0.597222222222222 4.2 4 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.72596808922361e-07 1.20987812362818e-06 1.75546511627907 0.596153846153846 4.2 4 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.72596808922361e-07 1.20987812362818e-06 1.75546511627907 0.596153846153846 4.2 4 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 6.92929874715492e-07 3.92844307458225e-06 1.75426026719446 0.595744680851064 4.2 4 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.40288678096704e-11 4.84230788931611e-10 1.75276854928018 0.595238095238095 4.2 4 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.40288678096704e-11 4.84230788931611e-10 1.75276854928018 0.595238095238095 4.2 4 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 1.13453905112671e-05 5.04515334297909e-05 1.75087366436204 0.594594594594595 4.2 4 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 9.10017700838663e-17 2.81511997455091e-15 1.74907851022906 0.593984962406015 4.2 4 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.000191906714174007 0.000687867139218166 1.74497846683893 0.592592592592593 4.2 4 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.63147068188226e-09 1.71969094838404e-08 1.74190632165084 0.591549295774648 4.2 4 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.000805424109204924 0.00256402350648458 1.74002114164905 0.590909090909091 4.2 4 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000805424109204924 0.00256402350648458 1.74002114164905 0.590909090909091 4.2 4 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 4.10263026211805e-07 2.65365584681545e-06 1.73214774281806 0.588235294117647 4.2 4 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 3.54222722627924e-05 0.000145681772918941 1.73214774281806 0.588235294117647 4.2 4 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00345689381991448 0.00945992289565059 1.73214774281806 0.588235294117647 4.2 4 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00345689381991448 0.00945992289565059 1.73214774281806 0.588235294117647 4.2 4 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000145685504625649 0.000526168713406848 1.72617481956696 0.586206896551724 4.2 4 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000145685504625649 0.000526168713406848 1.72617481956696 0.586206896551724 4.2 4 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 6.64438257505983e-06 3.02075284482752e-05 1.72369824163358 0.585365853658537 4.2 4 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.95490515271738e-09 3.04697828428756e-08 1.71771317829457 0.583333333333333 4.2 4 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.69686799407983e-05 0.000113539738330639 1.71771317829457 0.583333333333333 4.2 4 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0153980471025702 0.0348353275468321 1.71771317829457 0.583333333333333 4.2 4 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0153980471025702 0.0348353275468321 1.71771317829457 0.583333333333333 4.2 4 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0153980471025702 0.0348353275468321 1.71771317829457 0.583333333333333 4.2 4 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0153980471025702 0.0348353275468321 1.71771317829457 0.583333333333333 4.2 4 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.79022451245858e-13 5.15647984575138e-12 1.71325158562368 0.581818181818182 4.2 4 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 2.41028286685975e-07 1.65929070243908e-06 1.71325158562368 0.581818181818182 4.2 4 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 2.41028286685975e-07 1.65929070243908e-06 1.71325158562368 0.581818181818182 4.2 4 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000110336785172254 0.000418691320800313 1.70979744936234 0.580645161290323 4.2 4 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000110336785172254 0.000418691320800313 1.70979744936234 0.580645161290323 4.2 4 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 8.96667670940779e-09 8.02489368395427e-08 1.70704415234243 0.579710144927536 4.2 4 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00257456046567215 0.00726904671161005 1.70479804161567 0.578947368421053 4.2 4 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00257456046567215 0.00726904671161005 1.70479804161567 0.578947368421053 4.2 4 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.54920050630856e-08 2.75276131270675e-07 1.70237645348837 0.578125 4.2 4 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 3.85988816750414e-06 1.80678317840737e-05 1.70135400516796 0.577777777777778 4.2 4 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 8.34110458476211e-05 0.000321663735070907 1.6954052149401 0.575757575757576 4.2 4 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.93600135411391e-20 1.14788746954337e-18 1.68490734983211 0.572192513368984 4.2 4 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00191522429218875 0.005596230323993 1.68265780730897 0.571428571428571 4.2 4 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.0112423443005096 0.0261402874830477 1.68265780730897 0.571428571428571 4.2 4 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0112423443005096 0.0261402874830477 1.68265780730897 0.571428571428571 4.2 4 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0112423443005096 0.0261402874830477 1.68265780730897 0.571428571428571 4.2 4 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0112423443005096 0.0261402874830477 1.68265780730897 0.571428571428571 4.2 4 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0112423443005096 0.0261402874830477 1.68265780730897 0.571428571428571 4.2 4 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0112423443005096 0.0261402874830477 1.68265780730897 0.571428571428571 4.2 4 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 1.57979280050003e-08 1.32237950300679e-07 1.68265780730897 0.571428571428571 4.2 4 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 6.29641560996528e-05 0.000248193889556249 1.68265780730897 0.571428571428571 4.2 4 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 6.29641560996528e-05 0.000248193889556249 1.68265780730897 0.571428571428571 4.2 4 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.33646963022174e-09 2.44470314985702e-08 1.67733294083014 0.569620253164557 4.2 4 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.69108330467384e-06 8.4732800794045e-06 1.67440948472412 0.568627450980392 4.2 4 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.69108330467384e-06 8.4732800794045e-06 1.67440948472412 0.568627450980392 4.2 4 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.9592083170114e-23 2.33941857505957e-21 1.67309725158562 0.568181818181818 4.2 4 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 8.91120977216652e-06 4.01286440056739e-05 1.67309725158562 0.568181818181818 4.2 4 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 9.16640366961729e-09 8.10173442351889e-08 1.67128849780013 0.567567567567568 4.2 4 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 9.16640366961729e-09 8.10173442351889e-08 1.67128849780013 0.567567567567568 4.2 4 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 4.74742473170581e-05 0.00019029818009063 1.67128849780013 0.567567567567568 4.2 4 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 4.74742473170581e-05 0.00019029818009063 1.67128849780013 0.567567567567568 4.2 4 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.64392272139714e-10 3.18839155300689e-09 1.66863565891473 0.566666666666667 4.2 4 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 1.28169125356043e-06 6.75498760672775e-06 1.66678367705134 0.566037735849057 4.2 4 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 3.59812792806363e-08 2.75276131270675e-07 1.66436804853387 0.565217391304348 4.2 4 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.59812792806363e-08 2.75276131270675e-07 1.66436804853387 0.565217391304348 4.2 4 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00142391625530909 0.00428379034102501 1.66436804853387 0.565217391304348 4.2 4 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 9.7060164727538e-07 5.21194771348251e-06 1.65971247357294 0.563636363636364 4.2 4 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 9.7060164727538e-07 5.21194771348251e-06 1.65971247357294 0.563636363636364 4.2 4 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 9.7060164727538e-07 5.21194771348251e-06 1.65971247357294 0.563636363636364 4.2 4 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 9.7060164727538e-07 5.21194771348251e-06 1.65971247357294 0.563636363636364 4.2 4 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.40855643744686e-12 5.77425691724628e-11 1.65636627906977 0.5625 4.2 4 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00822112842437001 0.019694723481277 1.65636627906977 0.5625 4.2 4 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00822112842437001 0.019694723481277 1.65636627906977 0.5625 4.2 4 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00822112842437001 0.019694723481277 1.65636627906977 0.5625 4.2 4 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 3.84083700775579e-06 1.80379903037508e-05 1.64900465116279 0.56 4.2 4 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00105840408204623 0.00328310406815992 1.64900465116279 0.56 4.2 4 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00105840408204623 0.00328310406815992 1.64900465116279 0.56 4.2 4 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00105840408204623 0.00328310406815992 1.64900465116279 0.56 4.2 4 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.32103025167629e-85 4.72582604813536e-82 1.64554035567715 0.558823529411765 4.2 4 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000144196825721736 0.000523541621743204 1.64554035567715 0.558823529411765 4.2 4 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.02495890736766e-05 8.62729498558139e-05 1.64352623039481 0.558139534883721 4.2 4 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.02495890736766e-05 8.62729498558139e-05 1.64352623039481 0.558139534883721 4.2 4 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 4.198166480759e-07 2.70316330412672e-06 1.6412809759817 0.557377049180328 4.2 4 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000107958501298221 0.00041186312961761 1.6359173126615 0.555555555555556 4.2 4 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00602200637512769 0.0150075570434443 1.6359173126615 0.555555555555556 4.2 4 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00602200637512769 0.0150075570434443 1.6359173126615 0.555555555555556 4.2 4 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.051686560071842 0.102867097877246 1.6359173126615 0.555555555555556 4.2 4 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.051686560071842 0.102867097877246 1.6359173126615 0.555555555555556 4.2 4 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.051686560071842 0.102867097877246 1.6359173126615 0.555555555555556 4.2 4 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.051686560071842 0.102867097877246 1.6359173126615 0.555555555555556 4.2 4 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.051686560071842 0.102867097877246 1.6359173126615 0.555555555555556 4.2 4 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.051686560071842 0.102867097877246 1.6359173126615 0.555555555555556 4.2 4 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.051686560071842 0.102867097877246 1.6359173126615 0.555555555555556 4.2 4 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.18457085637747e-06 1.07194632021557e-05 1.6359173126615 0.555555555555556 4.2 4 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.18457085637747e-06 1.07194632021557e-05 1.6359173126615 0.555555555555556 4.2 4 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00078671550955388 0.00252138777048462 1.6359173126615 0.555555555555556 4.2 4 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00078671550955388 0.00252138777048462 1.6359173126615 0.555555555555556 4.2 4 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.91465781116338e-16 5.56032258221528e-15 1.6339222915485 0.554878048780488 4.2 4 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.64638704006558e-06 8.30783247522453e-06 1.63007475083056 0.553571428571429 4.2 4 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.14430972711729e-05 5.07274997410562e-05 1.62895596239485 0.553191489361702 4.2 4 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.65362750478489e-08 2.10955974263067e-07 1.62730722154223 0.552631578947368 4.2 4 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.447700117935e-20 1.33964510300827e-18 1.626569213732 0.552380952380952 4.2 4 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.51676517718706e-10 3.08737659235964e-09 1.61955813953488 0.55 4.2 4 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 6.04706346833264e-05 0.000239692794301876 1.61955813953488 0.55 4.2 4 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 4.69415700122567e-15 1.20948737557078e-13 1.61480870217554 0.548387096774194 4.2 4 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 7.03258515507822e-07 3.93990892743162e-06 1.61480870217554 0.548387096774194 4.2 4 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 7.03258515507822e-07 3.93990892743162e-06 1.61480870217554 0.548387096774194 4.2 4 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 5.84794983857908e-08 4.28950135066909e-07 1.60974263565891 0.546666666666667 4.2 4 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.000323458921134694 0.00111026134605797 1.6061733615222 0.545454545454545 4.2 4 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000323458921134694 0.00111026134605797 1.6061733615222 0.545454545454545 4.2 4 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.000323458921134694 0.00111026134605797 1.6061733615222 0.545454545454545 4.2 4 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 6.21276770008829e-11 8.41977946402442e-10 1.6061733615222 0.545454545454545 4.2 4 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 3.64133390729998e-06 1.72720605002929e-05 1.6061733615222 0.545454545454545 4.2 4 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00324698451176936 0.00893705795018917 1.6061733615222 0.545454545454545 4.2 4 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00324698451176936 0.00893705795018917 1.6061733615222 0.545454545454545 4.2 4 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00324698451176936 0.00893705795018917 1.6061733615222 0.545454545454545 4.2 4 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0366095758885668 0.0755006181006239 1.6061733615222 0.545454545454545 4.2 4 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0366095758885668 0.0755006181006239 1.6061733615222 0.545454545454545 4.2 4 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0366095758885668 0.0755006181006239 1.6061733615222 0.545454545454545 4.2 4 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 4.43331007584629e-15 1.16825930332024e-13 1.60115406976744 0.54375 4.2 4 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.05200291606923e-06 1.01742165490122e-05 1.59709893575089 0.542372881355932 4.2 4 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.05200291606923e-06 1.01742165490122e-05 1.59709893575089 0.542372881355932 4.2 4 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 2.05200291606923e-06 1.01742165490122e-05 1.59709893575089 0.542372881355932 4.2 4 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.72782014107385e-12 2.99840007408304e-11 1.59595597372626 0.541984732824427 4.2 4 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.72782014107385e-12 2.99840007408304e-11 1.59595597372626 0.541984732824427 4.2 4 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00238956150119633 0.00678711779681114 1.59501937984496 0.541666666666667 4.2 4 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00238956150119633 0.00678711779681114 1.59501937984496 0.541666666666667 4.2 4 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.54018456646593e-06 7.79958234192531e-06 1.59300800609989 0.540983606557377 4.2 4 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 9.39422745936978e-17 2.84425227120919e-15 1.59300800609989 0.540983606557377 4.2 4 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.19863094599767e-09 1.28244498958999e-08 1.59251542477456 0.540816326530612 4.2 4 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 9.03409117516461e-10 9.7390240471661e-09 1.59011162790698 0.54 4.2 4 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.72575704577867e-28 1.7541087686736e-26 1.58975032101584 0.539877300613497 4.2 4 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00176089830251499 0.0052312281513128 1.58558139534884 0.538461538461538 4.2 4 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0261489245728966 0.0562933731728167 1.58558139534884 0.538461538461538 4.2 4 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0261489245728966 0.0562933731728167 1.58558139534884 0.538461538461538 4.2 4 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0261489245728966 0.0562933731728167 1.58558139534884 0.538461538461538 4.2 4 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 8.67516346245208e-07 4.76631567840514e-06 1.58558139534884 0.538461538461538 4.2 4 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.37513984128683e-20 1.33964510300827e-18 1.57974847789201 0.536480686695279 4.2 4 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.32592364584684e-44 3.14464891340009e-42 1.57709781377929 0.535580524344569 4.2 4 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 4.4482370571193e-06 2.06857559878456e-05 1.57386527666399 0.53448275862069 4.2 4 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 5.51473956154822e-05 0.000219908990845854 1.57048062015504 0.533333333333333 4.2 4 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.32962466094365e-06 1.60069455828474e-05 1.57048062015504 0.533333333333333 4.2 4 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.000959643991265335 0.00302787893474628 1.57048062015504 0.533333333333333 4.2 4 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 6.54666123484793e-08 4.75300966183092e-07 1.5610198935276 0.530120481927711 4.2 4 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0135808923543825 0.0312375920660561 1.55893296853625 0.529411764705882 4.2 4 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0135808923543825 0.0312375920660561 1.55893296853625 0.529411764705882 4.2 4 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0135808923543825 0.0312375920660561 1.55893296853625 0.529411764705882 4.2 4 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 5.86840497426558e-07 3.36723398321771e-06 1.55412144702842 0.527777777777778 4.2 4 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000388974754568258 0.00129932177406252 1.55412144702842 0.527777777777778 4.2 4 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 4.21687736624111e-10 4.87854999362691e-09 1.54981640146879 0.526315789473684 4.2 4 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.38823554191007e-13 4.47165681070793e-12 1.54687371209891 0.525316455696203 4.2 4 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 5.30417924795356e-06 2.4426689546401e-05 1.54473503621807 0.524590163934426 4.2 4 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.30417924795356e-06 2.4426689546401e-05 1.54473503621807 0.524590163934426 4.2 4 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.96281343133293e-06 1.84887984025795e-05 1.54243632336656 0.523809523809524 4.2 4 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 5.2420080657773e-22 3.39062612618232e-20 1.54142389387961 0.523465703971119 4.2 4 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.21337916421751e-06 1.07864333927449e-05 1.53825060742798 0.522388059701492 4.2 4 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.21337916421751e-06 1.07864333927449e-05 1.53825060742798 0.522388059701492 4.2 4 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00523578624608963 0.0132807911375856 1.53633973710819 0.521739130434783 4.2 4 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00383164870527561 0.010268241257264 1.53121860465116 0.52 4.2 4 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00383164870527561 0.010268241257264 1.53121860465116 0.52 4.2 4 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00281001823339619 0.00788689535724414 1.52685615848407 0.518518518518518 4.2 4 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00281001823339619 0.00788689535724414 1.52685615848407 0.518518518518518 4.2 4 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00281001823339619 0.00788689535724414 1.52685615848407 0.518518518518518 4.2 4 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.11329058529735e-05 4.96618339460229e-05 1.52140310077519 0.516666666666667 4.2 4 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 6.19480285078239e-06 2.83447088638693e-05 1.51833575581395 0.515625 4.2 4 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.04049588005594e-10 1.35837214432991e-09 1.5169415081043 0.515151515151515 4.2 4 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 9.21370845937825e-14 1.84663480812609e-12 1.51391669951386 0.514124293785311 4.2 4 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.05757308760826e-71 9.75975501222183e-69 1.5121181646763 0.513513513513513 4.2 4 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000334237338685371 0.00113784625107484 1.50823596142938 0.51219512195122 4.2 4 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00024764241451122 0.000872265237251155 1.50656571119524 0.511627906976744 4.2 4 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.035082735769e-11 1.67377583295374e-10 1.4912015503876 0.506410256410256 4.2 4 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 9.18631139637617e-07 5.02773889117049e-06 1.49050244042492 0.506172839506173 4.2 4 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.06693679817067e-33 1.51825106379686e-31 1.49028077141237 0.50609756097561 4.2 4 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000377324656775505 0.00128146297515881 1.47232558139535 0.5 4.2 4 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0012636859596007 0.00385058912315161 1.47232558139535 0.5 4.2 4 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.00432082494912833 0.0113651273615705 1.47232558139535 0.5 4.2 4 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00432082494912833 0.0113651273615705 1.47232558139535 0.5 4.2 4 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00432082494912833 0.0113651273615705 1.47232558139535 0.5 4.2 4 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00590239910803623 0.0147611844125405 1.47232558139535 0.5 4.2 4 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00590239910803623 0.0147611844125405 1.47232558139535 0.5 4.2 4 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00590239910803623 0.0147611844125405 1.47232558139535 0.5 4.2 4 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00590239910803623 0.0147611844125405 1.47232558139535 0.5 4.2 4 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.00808201099098294 0.019694723481277 1.47232558139535 0.5 4.2 4 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0110970667561431 0.0260579636864549 1.47232558139535 0.5 4.2 4 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0152865406337929 0.0348043957150196 1.47232558139535 0.5 4.2 4 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0211397783336372 0.0460672351742202 1.47232558139535 0.5 4.2 4 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0211397783336372 0.0460672351742202 1.47232558139535 0.5 4.2 4 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0211397783336372 0.0460672351742202 1.47232558139535 0.5 4.2 4 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0211397783336372 0.0460672351742202 1.47232558139535 0.5 4.2 4 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0293732321649266 0.0621995675159087 1.47232558139535 0.5 4.2 4 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0293732321649266 0.0621995675159087 1.47232558139535 0.5 4.2 4 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0410555048452835 0.0838192014273149 1.47232558139535 0.5 4.2 4 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0410555048452835 0.0838192014273149 1.47232558139535 0.5 4.2 4 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0578211046745632 0.11240359556271 1.47232558139535 0.5 4.2 4 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0578211046745632 0.11240359556271 1.47232558139535 0.5 4.2 4 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0578211046745632 0.11240359556271 1.47232558139535 0.5 4.2 4 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0578211046745632 0.11240359556271 1.47232558139535 0.5 4.2 4 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0578211046745632 0.11240359556271 1.47232558139535 0.5 4.2 4 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0578211046745632 0.11240359556271 1.47232558139535 0.5 4.2 4 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0578211046745632 0.11240359556271 1.47232558139535 0.5 4.2 4 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0822606357470153 0.151236285100779 1.47232558139535 0.5 4.2 4 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 5.5889424214361e-11 7.72142239388697e-10 1.47232558139535 0.5 4.2 4 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00316955393918622 0.00877485458261087 1.47232558139535 0.5 4.2 4 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.12058650368867e-12 2.01847417056832e-11 1.46428008641505 0.497267759562842 4.2 4 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 6.26812016128478e-10 7.02325589725058e-09 1.4617333110256 0.496402877697842 4.2 4 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 8.93829210675495e-17 2.81511997455091e-15 1.44967441860465 0.492307692307692 4.2 4 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.03146593179616e-10 1.35837214432991e-09 1.44454585344449 0.490566037735849 4.2 4 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.37484949112179e-10 1.7785552962421e-09 1.44419197155977 0.490445859872611 4.2 4 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 1.26906029122035e-12 2.2573409930082e-11 1.43495691181679 0.487309644670051 4.2 4 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 2.36586350263988e-05 0.000100496231768852 1.43025913621262 0.485714285714286 4.2 4 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00255317924601284 0.00723739853999258 1.43025913621262 0.485714285714286 4.2 4 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.31470643001328e-16 3.89755677064354e-15 1.4290218878249 0.485294117647059 4.2 4 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.56732509107736e-08 2.75276131270675e-07 1.42405261151353 0.483606557377049 4.2 4 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00642663586743742 0.0158769146516727 1.42155573376103 0.482758620689655 4.2 4 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 4.47048197036191e-06 2.07214848333062e-05 1.42036114911081 0.482352941176471 4.2 4 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00877389563448767 0.0209484118924093 1.41779500430663 0.481481481481481 4.2 4 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00877389563448767 0.0209484118924093 1.41779500430663 0.481481481481481 4.2 4 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000822032623680477 0.00261105451673509 1.40831142568251 0.478260869565217 4.2 4 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0164699072236922 0.036562680154936 1.40831142568251 0.478260869565217 4.2 4 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0164699072236922 0.036562680154936 1.40831142568251 0.478260869565217 4.2 4 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0164699072236922 0.036562680154936 1.40831142568251 0.478260869565217 4.2 4 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.87075522773472e-07 2.51510716395731e-06 1.40478771068914 0.477064220183486 4.2 4 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 6.45885331597222e-06 2.94581675276553e-05 1.40384532179557 0.476744186046512 4.2 4 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.56591849714168e-12 4.39915906196701e-11 1.40221483942414 0.476190476190476 4.2 4 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0226633724518261 0.0491615533520558 1.40221483942414 0.476190476190476 4.2 4 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0226633724518261 0.0491615533520558 1.40221483942414 0.476190476190476 4.2 4 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0312983271868403 0.0661775922538986 1.39483476132191 0.473684210526316 4.2 4 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 5.98426890728315e-08 4.36698187439176e-07 1.3924319451956 0.472868217054264 4.2 4 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 1.26005131556054e-09 1.33809927018108e-08 1.39103153088886 0.47239263803681 4.2 4 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00370693639701321 0.0101053074577582 1.39052971576227 0.472222222222222 4.2 4 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.04000278432069e-08 1.67799072953083e-07 1.3881926910299 0.471428571428571 4.2 4 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 3.93730484221603e-09 3.91803132200937e-08 1.38683570892723 0.470967741935484 4.2 4 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00502586545861692 0.0127710831207355 1.38571819425445 0.470588235294118 4.2 4 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00502586545861692 0.0127710831207355 1.38571819425445 0.470588235294118 4.2 4 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0434108675520771 0.0879966731148229 1.38571819425445 0.470588235294118 4.2 4 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0434108675520771 0.0879966731148229 1.38571819425445 0.470588235294118 4.2 4 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0434108675520771 0.0879966731148229 1.38571819425445 0.470588235294118 4.2 4 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0434108675520771 0.0879966731148229 1.38571819425445 0.470588235294118 4.2 4 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000118404858443413 0.000445535343395173 1.38309372797745 0.46969696969697 4.2 4 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00682306748266318 0.0168270797709354 1.38030523255814 0.46875 4.2 4 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.8398319188908e-08 2.90642596839447e-07 1.37699514806759 0.467625899280576 4.2 4 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.77051930528764e-10 3.31298232892799e-09 1.37630434782609 0.467391304347826 4.2 4 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.00927658255465719 0.0221115192215698 1.37417054263566 0.466666666666667 4.2 4 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0605315388270895 0.116715961722152 1.37417054263566 0.466666666666667 4.2 4 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0605315388270895 0.116715961722152 1.37417054263566 0.466666666666667 4.2 4 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0605315388270895 0.116715961722152 1.37417054263566 0.466666666666667 4.2 4 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0605315388270895 0.116715961722152 1.37417054263566 0.466666666666667 4.2 4 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0605315388270895 0.116715961722152 1.37417054263566 0.466666666666667 4.2 4 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 4.44708255143909e-09 4.39458227131793e-08 1.37173190813231 0.46583850931677 4.2 4 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000381559426114444 0.00128663285156601 1.3707858861267 0.46551724137931 4.2 4 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000381559426114444 0.00128663285156601 1.3707858861267 0.46551724137931 4.2 4 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000381559426114444 0.00128663285156601 1.3707858861267 0.46551724137931 4.2 4 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00288424427826812 0.0080634176973979 1.36459444129325 0.463414634146341 4.2 4 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00288424427826812 0.0080634176973979 1.36459444129325 0.463414634146341 4.2 4 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 6.23318819781664e-09 6.07522383937882e-08 1.36326442721792 0.462962962962963 4.2 4 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0849686876188489 0.154026041377862 1.35906976744186 0.461538461538462 4.2 4 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0849686876188489 0.154026041377862 1.35906976744186 0.461538461538462 4.2 4 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0849686876188489 0.154026041377862 1.35906976744186 0.461538461538462 4.2 4 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0849686876188489 0.154026041377862 1.35906976744186 0.461538461538462 4.2 4 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0849686876188489 0.154026041377862 1.35906976744186 0.461538461538462 4.2 4 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0849686876188489 0.154026041377862 1.35906976744186 0.461538461538462 4.2 4 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 5.51704214560576e-05 0.000219908990845854 1.35906976744186 0.461538461538462 4.2 4 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000223544079583767 0.000789338027909928 1.35906976744186 0.461538461538462 4.2 4 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00389253568501031 0.0104118012777625 1.35906976744186 0.461538461538462 4.2 4 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 6.12727841238326e-06 2.81261844542625e-05 1.35453953488372 0.46 4.2 4 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 1.5268608210927e-08 1.28563488071889e-07 1.35194676027497 0.459119496855346 4.2 4 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 1.5268608210927e-08 1.28563488071889e-07 1.35194676027497 0.459119496855346 4.2 4 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 3.62843253902955e-06 1.72684264315687e-05 1.34848511193219 0.457943925233645 4.2 4 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 5.76543428845629e-05 0.000229167960683612 1.34508756818834 0.45679012345679 4.2 4 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 5.45338812174133e-07 3.36723398321771e-06 1.34480131843985 0.456692913385827 4.2 4 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00222978689411055 0.00641007424306933 1.34429726996967 0.456521739130435 4.2 4 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00222978689411055 0.00641007424306933 1.34429726996967 0.456521739130435 4.2 4 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.8135605300507e-35 4.44855181584683e-33 1.34224816127207 0.455825864276569 4.2 4 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 7.67740941435345e-05 0.000298495999907786 1.34186635266412 0.455696202531646 4.2 4 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 9.58716521854821e-07 5.21194771348251e-06 1.34065418793723 0.455284552845528 4.2 4 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.44846791250034e-07 1.03058491974399e-06 1.3384778012685 0.454545454545455 4.2 4 2 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.120303185629055 0.207253551029232 1.3384778012685 0.454545454545455 4.2 4 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.120303185629055 0.207253551029232 1.3384778012685 0.454545454545455 4.2 4 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.120303185629055 0.207253551029232 1.3384778012685 0.454545454545455 4.2 4 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.120303185629055 0.207253551029232 1.3384778012685 0.454545454545455 4.2 4 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.120303185629055 0.207253551029232 1.3384778012685 0.454545454545455 4.2 4 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.120303185629055 0.207253551029232 1.3384778012685 0.454545454545455 4.2 4 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 4.50238860464288e-05 0.000182014175693376 1.33536506219578 0.453488372093023 4.2 4 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.00041524106612647 0.00137439169525335 1.33429505813953 0.453125 4.2 4 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00542167034631835 0.0137034403247087 1.32509302325581 0.45 4.2 4 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00542167034631835 0.0137034403247087 1.32509302325581 0.45 4.2 4 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0443988798211517 0.0894895268916415 1.32509302325581 0.45 4.2 4 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0443988798211517 0.0894895268916415 1.32509302325581 0.45 4.2 4 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0443988798211517 0.0894895268916415 1.32509302325581 0.45 4.2 4 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 3.4791961588918e-07 2.29208154356622e-06 1.32509302325581 0.45 4.2 4 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.4791961588918e-07 2.29208154356622e-06 1.32509302325581 0.45 4.2 4 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 6.080537699738e-07 3.46104205869087e-06 1.32076265389877 0.448529411764706 4.2 4 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.72369877519491e-09 3.73156574443828e-08 1.31895833333333 0.447916666666667 4.2 4 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000186761669272205 0.000671115796399867 1.31734394124847 0.447368421052632 4.2 4 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00729796745970302 0.0179671413411028 1.31734394124847 0.447368421052632 4.2 4 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.74027778333137e-07 2.99796234919135e-06 1.31569520039584 0.446808510638298 4.2 4 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.00131764931459175 0.00398939356311503 1.31457641196013 0.446428571428571 4.2 4 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.14952062195931e-06 1.52441083164901e-05 1.31414184124544 0.446280991735537 4.2 4 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.14952062195931e-06 1.52441083164901e-05 1.31414184124544 0.446280991735537 4.2 4 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 8.2634135491509e-07 4.55768894590765e-06 1.31112205058564 0.445255474452555 4.2 4 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 8.2634135491509e-07 4.55768894590765e-06 1.31112205058564 0.445255474452555 4.2 4 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000144222287929259 0.000523541621743204 1.3087338501292 0.444444444444444 4.2 4 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0240067366629082 0.0519173043637058 1.3087338501292 0.444444444444444 4.2 4 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0240067366629082 0.0519173043637058 1.3087338501292 0.444444444444444 4.2 4 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0612277389268289 0.11789860959794 1.3087338501292 0.444444444444444 4.2 4 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00058160508812231 0.00188524838359464 1.29911080711354 0.441176470588235 4.2 4 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.000194827216172244 0.000696580725158551 1.29277368122518 0.439024390243902 4.2 4 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.084765777342105 0.154026041377862 1.28828488372093 0.4375 4.2 4 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.084765777342105 0.154026041377862 1.28828488372093 0.4375 4.2 4 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.45922751442296e-24 1.22145926648463e-22 1.28685377409671 0.43701399688958 4.2 4 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.000197503453438232 0.00070261853560651 1.28178932968536 0.435294117647059 4.2 4 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.000197503453438232 0.00070261853560651 1.28178932968536 0.435294117647059 4.2 4 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000260774284867156 0.000909514233740106 1.2771980947044 0.433734939759036 4.2 4 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.75626482544391e-05 7.61940502014231e-05 1.26546992119931 0.429752066115702 4.2 4 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 3.52258209524849e-06 1.68270882145093e-05 1.26495578119882 0.429577464788732 4.2 4 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.00181240328296372 0.00537302056595285 1.26199335548173 0.428571428571429 4.2 4 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00559561657169471 0.014093030763755 1.26199335548173 0.428571428571429 4.2 4 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00994066474454858 0.0235759432191544 1.26199335548173 0.428571428571429 4.2 4 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.03253687148874 0.0673944223121937 1.26199335548173 0.428571428571429 4.2 4 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.117903574699023 0.20599176516351 1.26199335548173 0.428571428571429 4.2 4 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.117903574699023 0.20599176516351 1.26199335548173 0.428571428571429 4.2 4 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.117903574699023 0.20599176516351 1.26199335548173 0.428571428571429 4.2 4 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.117903574699023 0.20599176516351 1.26199335548173 0.428571428571429 4.2 4 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.117903574699023 0.20599176516351 1.26199335548173 0.428571428571429 4.2 4 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.117903574699023 0.20599176516351 1.26199335548173 0.428571428571429 4.2 4 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.76464365463136e-05 7.63248608066997e-05 1.25860090022506 0.42741935483871 4.2 4 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.05453493494367e-15 2.88577540850932e-14 1.25444780477631 0.426008968609865 4.2 4 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.08337921116372e-06 1.02939188107152e-05 1.25385146286572 0.425806451612903 4.2 4 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00557344297033082 0.014062073309895 1.24581395348837 0.423076923076923 4.2 4 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0439561796759763 0.088975311065312 1.24581395348837 0.423076923076923 4.2 4 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0176858976416114 0.039140019197532 1.23985312117503 0.421052631578947 4.2 4 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0829945838286386 0.152192387613599 1.23985312117503 0.421052631578947 4.2 4 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0829945838286386 0.152192387613599 1.23985312117503 0.421052631578947 4.2 4 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00737842411464217 0.0181338471764004 1.23675348837209 0.42 4.2 4 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.52387370901178e-06 1.68270882145093e-05 1.2330726744186 0.41875 4.2 4 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0097614163909302 0.0231894749988208 1.22693798449612 0.416666666666667 4.2 4 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0097614163909302 0.0231894749988208 1.22693798449612 0.416666666666667 4.2 4 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.164933243453693 0.274182249339492 1.22693798449612 0.416666666666667 4.2 4 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.164933243453693 0.274182249339492 1.22693798449612 0.416666666666667 4.2 4 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.164933243453693 0.274182249339492 1.22693798449612 0.416666666666667 4.2 4 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.164933243453693 0.274182249339492 1.22693798449612 0.416666666666667 4.2 4 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0129039978546763 0.0299061709237855 1.21626895854398 0.41304347826087 4.2 4 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.1649756330101e-08 1.75043200328033e-07 1.21525286083426 0.412698412698413 4.2 4 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.1649756330101e-08 1.75043200328033e-07 1.21525286083426 0.412698412698413 4.2 4 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.1649756330101e-08 1.75043200328033e-07 1.21525286083426 0.412698412698413 4.2 4 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0418295335994157 0.0852771150601268 1.19626453488372 0.40625 4.2 4 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.00125617486945328 0.00383591596401721 1.19109485236478 0.404494382022472 4.2 4 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00122782443612923 0.00375740682282128 1.18426188068756 0.402173913043478 4.2 4 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.75975355108671e-15 1.20948737557078e-13 1.18095466949049 0.401050788091068 4.2 4 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0015889085571849 0.00473016083028058 1.17786046511628 0.4 4.2 4 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0218181422562851 0.0474728079980027 1.17786046511628 0.4 4.2 4 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00210999361367445 0.00609030611005831 1.17786046511628 0.4 4.2 4 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00210999361367445 0.00609030611005831 1.17786046511628 0.4 4.2 4 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00210999361367445 0.00609030611005831 1.17786046511628 0.4 4.2 4 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00210999361367445 0.00609030611005831 1.17786046511628 0.4 4.2 4 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00210999361367445 0.00609030611005831 1.17786046511628 0.4 4.2 4 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00498375255666995 0.0127094621651279 1.17786046511628 0.4 4.2 4 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0772628350526525 0.143907086753828 1.17786046511628 0.4 4.2 4 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.156151598613645 0.264843533763072 1.17786046511628 0.4 4.2 4 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.156151598613645 0.264843533763072 1.17786046511628 0.4 4.2 4 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.156151598613645 0.264843533763072 1.17786046511628 0.4 4.2 4 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00205369075067561 0.00598852856190859 1.17116807610994 0.397727272727273 4.2 4 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00352645463172981 0.00963175612466702 1.16331897789262 0.395061728395062 4.2 4 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 6.6995215170001e-05 0.000261854425168145 1.16285587320397 0.394904458598726 4.2 4 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0534618131528759 0.104932634643507 1.1600140944327 0.393939393939394 4.2 4 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.44850832819945e-35 2.57653418878478e-33 1.15961085171228 0.39380245319561 4.2 4 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0739349542678094 0.137889174211131 1.15682724252492 0.392857142857143 4.2 4 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000903308087954752 0.00285646090924358 1.13441479222265 0.385245901639344 4.2 4 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.21491109085047 0.343230619843119 1.13255813953488 0.384615384615385 4.2 4 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.21491109085047 0.343230619843119 1.13255813953488 0.384615384615385 4.2 4 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.21491109085047 0.343230619843119 1.13255813953488 0.384615384615385 4.2 4 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.21491109085047 0.343230619843119 1.13255813953488 0.384615384615385 4.2 4 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.21491109085047 0.343230619843119 1.13255813953488 0.384615384615385 4.2 4 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.138278617978543 0.236219055682433 1.12177187153931 0.380952380952381 4.2 4 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.092823243429738 0.167623699746849 1.11693664795509 0.379310344827586 4.2 4 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.000129188969182317 0.000483778692490624 1.10424418604651 0.375 4.2 4 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.129832375763347 0.22232427281738 1.10424418604651 0.375 4.2 4 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.129832375763347 0.22232427281738 1.10424418604651 0.375 4.2 4 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.129832375763347 0.22232427281738 1.10424418604651 0.375 4.2 4 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.129832375763347 0.22232427281738 1.10424418604651 0.375 4.2 4 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.19898309137657 0.320308754557533 1.10424418604651 0.375 4.2 4 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.19898309137657 0.320308754557533 1.10424418604651 0.375 4.2 4 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.19898309137657 0.320308754557533 1.10424418604651 0.375 4.2 4 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.5750760845185e-07 1.76169868666818e-06 1.09440243750777 0.371657754010695 4.2 4 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.18451809865651 0.298713599986591 1.08487148102815 0.368421052631579 4.2 4 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0514544299932393 0.102867097877246 1.08170859041291 0.36734693877551 4.2 4 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0460908909546601 0.0927685117800301 1.0707822410148 0.363636363636364 4.2 4 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.107320606486237 0.189006464145934 1.0707822410148 0.363636363636364 4.2 4 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0277896792341409 0.0597352168431759 1.06334625322997 0.361111111111111 4.2 4 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0619490442392864 0.119126337773655 1.06007441860465 0.36 4.2 4 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0946089701626843 0.170415904482911 1.05705426356589 0.358974358974359 4.2 4 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0946089701626843 0.170415904482911 1.05705426356589 0.358974358974359 4.2 4 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0584379660402438 0.113447784004457 1.05562966213251 0.358490566037736 4.2 4 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.148467835459046 0.25301764054877 1.05166112956811 0.357142857142857 4.2 4 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.148467835459046 0.25301764054877 1.05166112956811 0.357142857142857 4.2 4 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.268804155379052 0.40391585333093 1.05166112956811 0.357142857142857 4.2 4 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.268804155379052 0.40391585333093 1.05166112956811 0.357142857142857 4.2 4 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.268804155379052 0.40391585333093 1.05166112956811 0.357142857142857 4.2 4 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.268804155379052 0.40391585333093 1.05166112956811 0.357142857142857 4.2 4 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0835127501770747 0.152945487132532 1.04698708010336 0.355555555555556 4.2 4 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0785040126821211 0.146027725551187 1.04289728682171 0.354166666666667 4.2 4 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.245493388020994 0.386434835347207 1.03928864569083 0.352941176470588 4.2 4 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.245493388020994 0.386434835347207 1.03928864569083 0.352941176470588 4.2 4 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.245493388020994 0.386434835347207 1.03928864569083 0.352941176470588 4.2 4 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.245493388020994 0.386434835347207 1.03928864569083 0.352941176470588 4.2 4 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.069441950703666 0.130881981260022 1.03608096468562 0.351851851851852 4.2 4 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.225329738535496 0.358662436170035 1.03062790697674 0.35 4.2 4 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0990724604148462 0.178005190871624 1.02422649140546 0.347826086956522 4.2 4 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0990724604148462 0.178005190871624 1.02422649140546 0.347826086956522 4.2 4 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.191867991221956 0.310259263078232 1.0193023255814 0.346153846153846 4.2 4 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0319944572305945 0.0663675111357667 0.990473572938689 0.336363636363636 4.2 4 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 0.00342674702106938 0.00941363129533151 0.990353530086557 0.336322869955157 4.2 4 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.193866127568003 0.313134505708591 0.981550387596899 0.333333333333333 4.2 4 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.246503165966682 0.387595585823855 0.981550387596899 0.333333333333333 4.2 4 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.294682732803108 0.436805759144607 0.981550387596899 0.333333333333333 4.2 4 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.294682732803108 0.436805759144607 0.981550387596899 0.333333333333333 4.2 4 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.294682732803108 0.436805759144607 0.981550387596899 0.333333333333333 4.2 4 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.294682732803108 0.436805759144607 0.981550387596899 0.333333333333333 4.2 4 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.294682732803108 0.436805759144607 0.981550387596899 0.333333333333333 4.2 4 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.20945802542218 0.336409447150973 0.981550387596899 0.333333333333333 4.2 4 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.20945802542218 0.336409447150973 0.981550387596899 0.333333333333333 4.2 4 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.226877512173275 0.360722569634156 0.981550387596899 0.333333333333333 4.2 4 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.013351864604923 0.0308938265574073 0.975843699296917 0.331395348837209 4.2 4 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.264018937985278 0.403881315647213 0.946495016611296 0.321428571428571 4.2 4 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.165849080355686 0.275383012072511 0.944510750329092 0.320754716981132 4.2 4 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.287491600580127 0.428826569838072 0.942288372093023 0.32 4.2 4 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.287491600580127 0.428826569838072 0.942288372093023 0.32 4.2 4 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.287491600580127 0.428826569838072 0.942288372093023 0.32 4.2 4 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.091266737035341 0.165022321221461 0.939782285997031 0.319148936170213 4.2 4 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.314346397032642 0.46305892647769 0.936934460887949 0.318181818181818 4.2 4 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.0123019164872473 0.0285573036889934 0.935359781121751 0.317647058823529 4.2 4 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00079092422553324 0.00252918016389618 0.933960065774019 0.317171717171717 4.2 4 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.13274921989482 0.227045841238377 0.929889840881273 0.315789473684211 4.2 4 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.345527948563076 0.502233167318956 0.929889840881273 0.315789473684211 4.2 4 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.345527948563076 0.502233167318956 0.929889840881273 0.315789473684211 4.2 4 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.345527948563076 0.502233167318956 0.929889840881273 0.315789473684211 4.2 4 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.278839925566096 0.4176728569269 0.920203488372093 0.3125 4.2 4 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.38247013484593 0.542604677187412 0.920203488372093 0.3125 4.2 4 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.121152628260031 0.208464558662664 0.918224556139035 0.311827956989247 4.2 4 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.329990982517091 0.48193553350122 0.906046511627907 0.307692307692308 4.2 4 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.269882936920294 0.404682212052242 0.906046511627907 0.307692307692308 4.2 4 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.151979768811858 0.258692836147457 0.903472515856237 0.306818181818182 4.2 4 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.220076205129707 0.35069254188082 0.898368151359874 0.305084745762712 4.2 4 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.361042300861985 0.524248157272046 0.896198179979778 0.304347826086957 4.2 4 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.397041467146325 0.559950453666225 0.883395348837209 0.3 4.2 4 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.397041467146325 0.559950453666225 0.883395348837209 0.3 4.2 4 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.397041467146325 0.559950453666225 0.883395348837209 0.3 4.2 4 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.290784292233173 0.433283819735922 0.877130133597229 0.297872340425532 4.2 4 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.373407180556593 0.531973305910422 0.872489233419466 0.296296296296296 4.2 4 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.373407180556593 0.531973305910422 0.872489233419466 0.296296296296296 4.2 4 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.269319663917191 0.404263588348273 0.868913457872665 0.295081967213115 4.2 4 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.43954377935632 0.601757798556746 0.866073871409029 0.294117647058824 4.2 4 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.43954377935632 0.601757798556746 0.866073871409029 0.294117647058824 4.2 4 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0866590030749939 0.156890281648494 0.863291304753899 0.293172690763052 4.2 4 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.321487595466905 0.473088778024204 0.858856589147287 0.291666666666667 4.2 4 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.383598246838044 0.542604677187412 0.85489872468117 0.290322580645161 4.2 4 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.383598246838044 0.542604677187412 0.85489872468117 0.290322580645161 4.2 4 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.383598246838044 0.542604677187412 0.85489872468117 0.290322580645161 4.2 4 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.283816296905348 0.424679905884658 0.853522076171217 0.289855072463768 4.2 4 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.255294462752773 0.39273948161859 0.841328903654485 0.285714285714286 4.2 4 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.417162477585119 0.581982554513358 0.841328903654485 0.285714285714286 4.2 4 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.448315934479266 0.608154027420397 0.841328903654485 0.285714285714286 4.2 4 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.424590633422719 0.591765398002477 0.828183139534884 0.28125 4.2 4 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.216194012519468 0.344892466160541 0.827685732243872 0.281081081081081 4.2 4 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.344884268719534 0.502233167318956 0.820029437739182 0.278481012658228 4.2 4 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.46071467788446 0.623784002501985 0.812317562149158 0.275862068965517 4.2 4 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.314298118246139 0.46305892647769 0.811518036989562 0.275590551181102 4.2 4 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.498554511021751 0.659333707420029 0.803086680761099 0.272727272727273 4.2 4 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.498554511021751 0.659333707420029 0.803086680761099 0.272727272727273 4.2 4 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.445500152193822 0.604910989095238 0.797509689922481 0.270833333333333 4.2 4 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.398700336747416 0.561177625313129 0.796787961696306 0.270588235294118 4.2 4 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.398700336747416 0.561177625313129 0.796787961696306 0.270588235294118 4.2 4 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.501260886059863 0.662297345276866 0.792790697674419 0.269230769230769 4.2 4 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.503571680661823 0.664733303879197 0.785240310077519 0.266666666666667 4.2 4 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.478930896437429 0.639923629699964 0.781233981964879 0.26530612244898 4.2 4 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.481509478432105 0.642765466987698 0.777832382623958 0.264150943396226 4.2 4 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.45321784728681 0.614218092084886 0.774908200734394 0.263157894736842 4.2 4 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.54873514432399 0.722340527634632 0.774908200734394 0.263157894736842 4.2 4 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.162236621671069 0.270965625161892 0.774227793533749 0.262926829268293 4.2 4 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.547088232254609 0.720839402313249 0.768169868554095 0.260869565217391 4.2 4 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.546009682986007 0.720085059211388 0.763428079242033 0.259259259259259 4.2 4 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.577370190851999 0.750066551883665 0.736162790697674 0.25 4.2 4 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.582828567659433 0.750066551883665 0.736162790697674 0.25 4.2 4 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.59338248498809 0.761391592550091 0.736162790697674 0.25 4.2 4 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.599299703383211 0.768291421544423 0.736162790697674 0.25 4.2 4 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.602971612643758 0.772302974610322 0.724094548227221 0.245901639344262 4.2 4 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.623985213613638 0.794924761837249 0.713854827343199 0.242424242424242 4.2 4 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.623985213613638 0.794924761837249 0.713854827343199 0.242424242424242 4.2 4 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.630823477832487 0.802917539316305 0.712415603900975 0.241935483870968 4.2 4 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.657387772693925 0.83152248937196 0.707848837209302 0.240384615384615 4.2 4 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.706405935844859 0.873341135279961 0.700252410663642 0.23780487804878 4.2 4 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.682071519947779 0.854655887715762 0.698216255094701 0.237113402061856 4.2 4 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.683451353826785 0.854655887715762 0.69015261627907 0.234375 4.2 4 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.677767136723399 0.854655887715762 0.67953488372093 0.230769230769231 4.2 4 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.746417963456837 0.918817268165294 0.646386840612592 0.219512195121951 4.2 4 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.773094420570058 0.92993521595198 0.630996677740864 0.214285714285714 4.2 4 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.767652469154172 0.924849311118069 0.6246229739253 0.212121212121212 4.2 4 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.783464552742131 0.941613225128423 0.619926560587515 0.210526315789474 4.2 4 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.797692176473521 0.955484820809613 0.616322336398053 0.209302325581395 4.2 4 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.810593738008904 0.964787796394563 0.613468992248062 0.208333333333333 4.2 4 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.795455611050961 0.954412592348666 0.60625170998632 0.205882352941176 4.2 4 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.808403598615419 0.964787796394563 0.604031007751938 0.205128205128205 4.2 4 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.966724453508184 1 0.597072125174151 0.202764976958525 4.2 4 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.797684284442291 0.955484820809613 0.588930232558139 0.2 4.2 4 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.809506464265574 0.964787796394563 0.588930232558139 0.2 4.2 4 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.809506464265574 0.964787796394563 0.588930232558139 0.2 4.2 4 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.851617963034031 1 0.574566080544526 0.195121951219512 4.2 4 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.834826442432313 0.989140739035121 0.56993248312078 0.193548387096774 4.2 4 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.863693930884465 1 0.557096165933375 0.189189189189189 4.2 4 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.863693930884465 1 0.557096165933375 0.189189189189189 4.2 4 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.851423227819807 1 0.545305770887166 0.185185185185185 4.2 4 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.873493623695294 1 0.525830564784053 0.178571428571429 4.2 4 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.894833194826789 1 0.519644322845417 0.176470588235294 4.2 4 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.9995704267511 1 0.496549019607843 0.168627450980392 4.2 4 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.978557367795063 1 0.484562849573153 0.164556962025316 4.2 4 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.953004461597428 1 0.480759373516849 0.163265306122449 4.2 4 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.989707503501548 1 0.4759032182288 0.161616161616162 4.2 4 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.923687023077814 1 0.474943735933983 0.161290322580645 4.2 4 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.923687023077814 1 0.474943735933983 0.161290322580645 4.2 4 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.923687023077814 1 0.474943735933983 0.161290322580645 4.2 4 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.983898639556334 1 0.456213560432362 0.154929577464789 4.2 4 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999203007405 1 0.455358427235675 0.154639175257732 4.2 4 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999982270531171 1 0.452214285714286 0.153571428571429 4.2 4 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999949338686393 1 0.411617904476119 0.139784946236559 4.2 4 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.390642219748892 0.132661628883291 4.2 4 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999808998649019 1 0.354448751076658 0.12037037037037 4.2 4 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999774751764053 1 0.3271834625323 0.111111111111111 4.2 4 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.316829555490138 0.107594936708861 4.2 4 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999963016065 1 0.284426532769556 0.0965909090909091 4.2 4 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.999621063387689 1 0.258302733578131 0.087719298245614 4.2 4 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.999903691205591 1 0.233702473237357 0.0793650793650794 4.2 4 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 1.41679563550846e-05 0.00012679875404582 4.80714012251149 0.875 4.4 4 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 3.63634826369486e-07 5.376000575301e-06 4.57822868810618 0.833333333333333 4.4 4 4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 3.34478557251802e-05 0.000260504311120081 3.99554503689266 0.727272727272727 4.4 4 4 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00138062190597006 0.00623690467363617 3.92419601837672 0.714285714285714 4.4 4 4 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00138062190597006 0.00623690467363617 3.92419601837672 0.714285714285714 4.4 4 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 2.34360449647588e-06 2.73356491679113e-05 3.7770386676876 0.6875 4.4 4 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 2.19231654014401e-12 1.15543201356479e-10 3.76722817764165 0.685714285714286 4.4 4 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000732133366141378 0.00360263953429078 3.66258295048494 0.666666666666667 4.4 4 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.15586480433252e-11 1.28308446187576e-09 3.46981542677521 0.631578947368421 4.4 4 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 2.42363590588854e-05 0.000204073011483987 3.43367151607963 0.625 4.4 4 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 2.42363590588854e-05 0.000204073011483987 3.43367151607963 0.625 4.4 4 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00321358888017079 0.0127062616188106 3.43367151607963 0.625 4.4 4 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00321358888017079 0.0127062616188106 3.43367151607963 0.625 4.4 4 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 6.54645994439845e-06 6.86078132894982e-05 3.29632465543645 0.6 4.4 4 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 4.42865270004127e-07 6.23957702193934e-06 3.29632465543645 0.6 4.4 4 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 5.07025406348211e-05 0.000345213948915552 3.23169083866318 0.588235294117647 4.4 4 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 5.07025406348211e-05 0.000345213948915552 3.23169083866318 0.588235294117647 4.4 4 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 1.31258562928493e-05 0.00011901102879228 3.13935681470138 0.571428571428571 4.4 4 4 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00631540827270756 0.0225233733635661 3.05215245873745 0.555555555555556 4.4 4 4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.00631540827270756 0.0225233733635661 3.05215245873745 0.555555555555556 4.4 4 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 2.28924001756415e-07 3.5797676318613e-06 2.9966587776695 0.545454545454545 4.4 4 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 2.48185049472501e-05 0.000206530599648754 2.9966587776695 0.545454545454545 4.4 4 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.00304528865330977 0.0122413721854797 2.9966587776695 0.545454545454545 4.4 4 4 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.00304528865330977 0.0122413721854797 2.9966587776695 0.545454545454545 4.4 4 4 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00304528865330977 0.0122413721854797 2.9966587776695 0.545454545454545 4.4 4 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 1.16776684664304e-07 2.02650271069884e-06 2.98238897396631 0.542857142857143 4.4 4 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00148390732287234 0.00659875037639793 2.95824007539168 0.538461538461538 4.4 4 4 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.00148390732287234 0.00659875037639793 2.95824007539168 0.538461538461538 4.4 4 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000728795844088487 0.00360263953429078 2.93006636038795 0.533333333333333 4.4 4 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000728795844088487 0.00360263953429078 2.93006636038795 0.533333333333333 4.4 4 4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000360139273983131 0.00191223204058953 2.90852175479686 0.529411764705882 4.4 4 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 2.23795040221223e-05 0.000191843579659518 2.85681470137825 0.52 4.4 4 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.23795040221223e-05 0.000191843579659518 2.85681470137825 0.52 4.4 4 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 9.72638573871813e-06 9.18920900480739e-05 2.74693721286371 0.5 4.4 4 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.6708062950006e-05 0.000498427276611227 2.74693721286371 0.5 4.4 4 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000153520630362465 0.000929616412790585 2.74693721286371 0.5 4.4 4 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0012612718612606 0.00580838141933279 2.74693721286371 0.5 4.4 4 4 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0012612718612606 0.00580838141933279 2.74693721286371 0.5 4.4 4 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00530076504101609 0.019340996547092 2.74693721286371 0.5 4.4 4 4 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00530076504101609 0.019340996547092 2.74693721286371 0.5 4.4 4 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00530076504101609 0.019340996547092 2.74693721286371 0.5 4.4 4 4 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00530076504101609 0.019340996547092 2.74693721286371 0.5 4.4 4 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0110395025294914 0.0364482879337964 2.74693721286371 0.5 4.4 4 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 3.84430848137118e-05 0.000284182758912982 2.74693721286371 0.5 4.4 4 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0025746310511719 0.0107252311339925 2.74693721286371 0.5 4.4 4 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0025746310511719 0.0107252311339925 2.74693721286371 0.5 4.4 4 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0025746310511719 0.0107252311339925 2.74693721286371 0.5 4.4 4 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0025746310511719 0.0107252311339925 2.74693721286371 0.5 4.4 4 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0025746310511719 0.0107252311339925 2.74693721286371 0.5 4.4 4 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.46718098825189e-13 1.97351941851298e-11 2.68305495209943 0.488372093023256 4.4 4 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.61602607199151e-05 0.000142832614934405 2.65832633502939 0.483870967741935 4.4 4 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 1.61602607199151e-05 0.000142832614934405 2.65832633502939 0.483870967741935 4.4 4 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 6.36894425768682e-05 0.000415734297187539 2.64519879757246 0.481481481481481 4.4 4 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 6.36894425768682e-05 0.000415734297187539 2.64519879757246 0.481481481481481 4.4 4 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000126857501960361 0.000774756331714993 2.63705972434916 0.48 4.4 4 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000126857501960361 0.000774756331714993 2.63705972434916 0.48 4.4 4 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000253356647992713 0.0014537359277969 2.6275051601305 0.478260869565217 4.4 4 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.4775842700974e-07 6.24666903563588e-06 2.62207643046081 0.477272727272727 4.4 4 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000507599578965944 0.00261708043792949 2.61613067891782 0.476190476190476 4.4 4 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0010208110657881 0.00478623003472406 2.60236157008141 0.473684210526316 4.4 4 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.03883197970249e-13 1.38155138434126e-11 2.60236157008141 0.473684210526316 4.4 4 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.09246157588125e-15 5.77971521498601e-13 2.59432958992683 0.472222222222222 4.4 4 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 1.32141549888828e-05 0.00011901102879228 2.58535267093055 0.470588235294118 4.4 4 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 1.32141549888828e-05 0.00011901102879228 2.58535267093055 0.470588235294118 4.4 4 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00206227860550723 0.00889279532011147 2.58535267093055 0.470588235294118 4.4 4 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00206227860550723 0.00889279532011147 2.58535267093055 0.470588235294118 4.4 4 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.60894797826406e-05 0.000215844940294753 2.57525363705972 0.46875 4.4 4 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 3.6645963162628e-07 5.376000575301e-06 2.57160079502134 0.468085106382979 4.4 4 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 7.17659380476214e-07 9.36907613227204e-06 2.56380806533946 0.466666666666667 4.4 4 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 7.17659380476214e-07 9.36907613227204e-06 2.56380806533946 0.466666666666667 4.4 4 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 5.15823854724399e-05 0.000349532069177533 2.56380806533946 0.466666666666667 4.4 4 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00418973685736988 0.0158143117985075 2.56380806533946 0.466666666666667 4.4 4 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00418973685736988 0.0158143117985075 2.56380806533946 0.466666666666667 4.4 4 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00418973685736988 0.0158143117985075 2.56380806533946 0.466666666666667 4.4 4 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00418973685736988 0.0158143117985075 2.56380806533946 0.466666666666667 4.4 4 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.64014880978474e-12 2.27687301942196e-10 2.55964603925936 0.465909090909091 4.4 4 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00010214684688489 0.000646022058298662 2.55072741194487 0.464285714285714 4.4 4 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000202641288086059 0.00119156426837381 2.53563435033573 0.461538461538462 4.4 4 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00857235737085361 0.0291829295184801 2.53563435033573 0.461538461538462 4.4 4 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.41967977584075e-11 6.51678813232704e-10 2.52591927619651 0.459770114942529 4.4 4 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.000402828527644235 0.00211922127464279 2.5180257784584 0.458333333333333 4.4 4 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.12887055952188e-06 1.42157770460145e-05 2.5080731073973 0.456521739130435 4.4 4 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 4.10284252106621e-05 0.000284182758912982 2.49721564805791 0.454545454545455 4.4 4 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000802665369468847 0.00392506123970505 2.49721564805791 0.454545454545455 4.4 4 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0177013474263094 0.0523680195169195 2.49721564805791 0.454545454545455 4.4 4 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.6083589623488e-07 6.30547577252148e-06 2.47762964297511 0.450980392156863 4.4 4 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.6083589623488e-07 6.30547577252148e-06 2.47762964297511 0.450980392156863 4.4 4 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 8.41977067223588e-06 8.55809547613689e-05 2.47224349157734 0.45 4.4 4 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 8.41977067223588e-06 8.55809547613689e-05 2.47224349157734 0.45 4.4 4 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00160373605291963 0.00704356914600197 2.47224349157734 0.45 4.4 4 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 5.45182842212450e-09 1.65062805206025e-07 2.4682624231529 0.449275362318841 4.4 4 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 1.64615258665422e-05 0.000144597230296849 2.45778592729911 0.447368421052632 4.4 4 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000313802764493414 0.00171088633668248 2.44172196698996 0.444444444444444 4.4 4 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0032145145346253 0.0127062616188106 2.44172196698996 0.444444444444444 4.4 4 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0032145145346253 0.0127062616188106 2.44172196698996 0.444444444444444 4.4 4 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0032145145346253 0.0127062616188106 2.44172196698996 0.444444444444444 4.4 4 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0032145145346253 0.0127062616188106 2.44172196698996 0.444444444444444 4.4 4 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 7.05965467693975e-07 9.36907613227204e-06 2.42998291907174 0.442307692307692 4.4 4 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 7.05965467693975e-07 9.36907613227204e-06 2.42998291907174 0.442307692307692 4.4 4 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.15731607071192e-11 9.02900226065608e-10 2.42887079874265 0.442105263157895 4.4 4 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.15731607071192e-11 9.02900226065608e-10 2.42887079874265 0.442105263157895 4.4 4 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 6.60524976856026e-06 6.86078132894982e-05 2.42752590904235 0.441860465116279 4.4 4 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 5.11982998648868e-13 2.80212233491284e-11 2.42522384559138 0.441441441441441 4.4 4 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 6.29870595962773e-05 0.000414956415766215 2.42376812899739 0.441176470588235 4.4 4 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 2.65196730004393e-06 3.0680889983435e-05 2.40357006125574 0.4375 4.4 4 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00646743185434377 0.0226678707604216 2.40357006125574 0.4375 4.4 4 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00646743185434377 0.0226678707604216 2.40357006125574 0.4375 4.4 4 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00646743185434377 0.0226678707604216 2.40357006125574 0.4375 4.4 4 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00646743185434377 0.0226678707604216 2.40357006125574 0.4375 4.4 4 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00646743185434377 0.0226678707604216 2.40357006125574 0.4375 4.4 4 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000241320890547327 0.001395933444101 2.38067891781521 0.433333333333333 4.4 4 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.2856328386354e-07 6.09845552937818e-06 2.36804932143423 0.431034482758621 4.4 4 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.2856328386354e-07 6.09845552937818e-06 2.36804932143423 0.431034482758621 4.4 4 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.89054326760186e-08 5.07593032037254e-07 2.36541815552152 0.430555555555556 4.4 4 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0024258384083849 0.010366270435831 2.35451761102603 0.428571428571429 4.4 4 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0024258384083849 0.010366270435831 2.35451761102603 0.428571428571429 4.4 4 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0130706521106149 0.0415651806678809 2.35451761102603 0.428571428571429 4.4 4 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0130706521106149 0.0415651806678809 2.35451761102603 0.428571428571429 4.4 4 4 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0130706521106149 0.0415651806678809 2.35451761102603 0.428571428571429 4.4 4 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.88264172311437e-13 1.70916632166323e-11 2.3481882626093 0.42741935483871 4.4 4 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.88264172311437e-13 1.70916632166323e-11 2.3481882626093 0.42741935483871 4.4 4 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.88264172311437e-13 1.70916632166323e-11 2.3481882626093 0.42741935483871 4.4 4 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.6510271550308e-06 7.8894287258035e-05 2.33781890456486 0.425531914893617 4.4 4 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.72587039484651e-05 0.000284182758912982 2.33489663093415 0.425 4.4 4 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.8018823418807e-08 7.11978316517185e-07 2.33301516708972 0.424657534246575 4.4 4 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.73096542710195e-13 1.23158190138304e-11 2.32433148780775 0.423076923076923 4.4 4 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 3.04776808881276e-06 3.46957919230445e-05 2.32433148780775 0.423076923076923 4.4 4 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 3.04776808881276e-06 3.46957919230445e-05 2.32433148780775 0.423076923076923 4.4 4 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000925478757346839 0.00446425854815102 2.32433148780775 0.423076923076923 4.4 4 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000925478757346839 0.00446425854815102 2.32433148780775 0.423076923076923 4.4 4 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000925478757346839 0.00446425854815102 2.32433148780775 0.423076923076923 4.4 4 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.0226696638787e-07 1.81907366462423e-06 2.30901968617529 0.420289855072464 4.4 4 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000357286194196318 0.00191134682083218 2.30388282369214 0.419354838709677 4.4 4 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.83698822566396e-05 0.000233354580642764 2.2997613875138 0.418604651162791 4.4 4 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 2.32950369284793e-06 2.73356491679113e-05 2.29743839621328 0.418181818181818 4.4 4 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.95099850205552e-07 3.08474540936112e-06 2.29594752119952 0.417910447761194 4.4 4 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00181262626282858 0.00788797300307359 2.28911434405309 0.416666666666667 4.4 4 4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0265589062729474 0.0726794685123157 2.28911434405309 0.416666666666667 4.4 4 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0265589062729474 0.0726794685123157 2.28911434405309 0.416666666666667 4.4 4 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0265589062729474 0.0726794685123157 2.28911434405309 0.416666666666667 4.4 4 4 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0265589062729474 0.0726794685123157 2.28911434405309 0.416666666666667 4.4 4 4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0265589062729474 0.0726794685123157 2.28911434405309 0.416666666666667 4.4 4 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0265589062729474 0.0726794685123157 2.28911434405309 0.416666666666667 4.4 4 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0265589062729474 0.0726794685123157 2.28911434405309 0.416666666666667 4.4 4 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 5.45471482517758e-05 0.000367870104086621 2.27794793261868 0.414634146341463 4.4 4 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.37817441616731e-10 1.63951110373844e-08 2.2752409237861 0.414141414141414 4.4 4 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 9.65805823352652e-09 2.74868337326165e-07 2.26218358706423 0.411764705882353 4.4 4 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 8.50715019545409e-06 8.58558491356821e-05 2.26218358706423 0.411764705882353 4.4 4 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00955103912852932 0.0319791263056405 2.26218358706423 0.411764705882353 4.4 4 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.13383525486484e-07 1.99191057737367e-06 2.25775661331263 0.410958904109589 4.4 4 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00354957358917292 0.0138006645283964 2.24749408325212 0.409090909090909 4.4 4 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00354957358917292 0.0138006645283964 2.24749408325212 0.409090909090909 4.4 4 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00134600600243357 0.00615873486000956 2.23824513640746 0.407407407407407 4.4 4 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00134600600243357 0.00615873486000956 2.23824513640746 0.407407407407407 4.4 4 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 7.85430170739125e-05 0.000508030514982625 2.22371107708014 0.404761904761905 4.4 4 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.73012158517527e-36 2.71798767190147e-33 2.21818404043454 0.403755868544601 4.4 4 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.77790254000367e-19 2.81106146047247e-17 2.21725873684066 0.403587443946188 4.4 4 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.92545947170056e-06 2.3418195113076e-05 2.21527194585783 0.403225806451613 4.4 4 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.52258399937368e-25 1.57172740622175e-22 2.21255011001991 0.402730375426621 4.4 4 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 5.19929273760959e-10 1.8970752732355e-08 2.2078186944512 0.401869158878505 4.4 4 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000384424936330842 0.00203359362230033 2.19754977029096 0.4 4.4 4 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.000995451359058229 0.00472175761313287 2.19754977029096 0.4 4.4 4 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.00694740136344384 0.024053898151291 2.19754977029096 0.4 4.4 4 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00694740136344384 0.024053898151291 2.19754977029096 0.4 4.4 4 4 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0189912622794449 0.0557207551003094 2.19754977029096 0.4 4.4 4 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0189912622794449 0.0557207551003094 2.19754977029096 0.4 4.4 4 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0189912622794449 0.0557207551003094 2.19754977029096 0.4 4.4 4 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000111348528300591 0.000698013021020884 2.17199686598526 0.395348837209302 4.4 4 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000734199202350194 0.00360263953429078 2.16425356165019 0.393939393939394 4.4 4 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000734199202350194 0.00360263953429078 2.16425356165019 0.393939393939394 4.4 4 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.68833038771973e-13 1.23158190138304e-11 2.16321305513017 0.39375 4.4 4 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.63395857977295e-41 6.59412305901691e-38 2.16203803445927 0.393536121673004 4.4 4 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00191118684343777 0.00829152097015838 2.1583078101072 0.392857142857143 4.4 4 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.92687132470856e-09 6.2316770342279e-08 2.15647407365001 0.392523364485981 4.4 4 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 8.26347706991214e-05 0.000532078184184841 2.14977694919768 0.391304347826087 4.4 4 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00504380697803298 0.0186909826295337 2.14977694919768 0.391304347826087 4.4 4 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000210663128148176 0.00123363634302409 2.14395099540582 0.390243902439024 4.4 4 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 8.89177271742368e-09 2.63604012018623e-07 2.14261102603369 0.39 4.4 4 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 9.60432653197703e-06 9.17245413087471e-05 2.14167986087679 0.389830508474576 4.4 4 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 9.60432653197703e-06 9.17245413087471e-05 2.14167986087679 0.389830508474576 4.4 4 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.000540515895040908 0.00275682479800435 2.13650672111622 0.388888888888889 4.4 4 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000540515895040908 0.00275682479800435 2.13650672111622 0.388888888888889 4.4 4 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.36493638271387e-07 2.25849357279284e-06 2.1329159535177 0.388235294117647 4.4 4 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.36493638271387e-07 2.25849357279284e-06 2.1329159535177 0.388235294117647 4.4 4 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.36493638271387e-07 2.25849357279284e-06 2.1329159535177 0.388235294117647 4.4 4 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 6.12296576544329e-05 0.00040714861141242 2.13027783854736 0.387755102040816 4.4 4 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 6.12296576544329e-05 0.00040714861141242 2.13027783854736 0.387755102040816 4.4 4 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 4.09984929712592e-08 9.56407467181996e-07 2.12666106802351 0.387096774193548 4.4 4 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 4.28376424425954e-20 7.61974564947665e-18 2.1259820574654 0.386973180076628 4.4 4 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.58278216929017e-16 3.06274918908327e-14 2.11906584992343 0.385714285714286 4.4 4 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 2.11922122538912e-06 2.555637121804e-05 2.11906584992343 0.385714285714286 4.4 4 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.53506029516932e-07 3.92107695654994e-06 2.11812026052141 0.385542168674699 4.4 4 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 9.21290123263206e-09 2.67550172531335e-07 2.11302862527977 0.384615384615385 4.4 4 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00365947042477109 0.0140741254444574 2.11302862527977 0.384615384615385 4.4 4 4 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.0378004993367561 0.0963980475917632 2.11302862527977 0.384615384615385 4.4 4 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0378004993367561 0.0963980475917632 2.11302862527977 0.384615384615385 4.4 4 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0378004993367561 0.0963980475917632 2.11302862527977 0.384615384615385 4.4 4 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.28324394930372e-08 6.01677062936888e-07 2.10875988058224 0.383838383838384 4.4 4 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00102249749160655 0.00478623003472406 2.10059904513107 0.382352941176471 4.4 4 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00102249749160655 0.00478623003472406 2.10059904513107 0.382352941176471 4.4 4 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00102249749160655 0.00478623003472406 2.10059904513107 0.382352941176471 4.4 4 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 6.25631311429439e-10 2.21564300061765e-08 2.0992853496682 0.382113821138211 4.4 4 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 3.35012571573962e-05 0.000260504311120081 2.09766114436865 0.381818181818182 4.4 4 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.49241125857664e-07 5.28691619250485e-06 2.09290454313425 0.380952380952381 4.4 4 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.49241125857664e-07 5.28691619250485e-06 2.09290454313425 0.380952380952381 4.4 4 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 9.85992909229094e-06 9.18920900480739e-05 2.09290454313425 0.380952380952381 4.4 4 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00972990164348013 0.0323496496230659 2.09290454313425 0.380952380952381 4.4 4 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00972990164348013 0.0323496496230659 2.09290454313425 0.380952380952381 4.4 4 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00972990164348013 0.0323496496230659 2.09290454313425 0.380952380952381 4.4 4 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 3.13767191297043e-08 7.80346219437668e-07 2.08767228177642 0.38 4.4 4 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 8.45753432621569e-05 0.000542120330910132 2.08767228177642 0.38 4.4 4 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 6.38379220135796e-10 2.21564300061765e-08 2.07642497980249 0.377952755905512 4.4 4 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 6.22957224199619e-05 0.000412310758156306 2.07316016065185 0.377358490566038 4.4 4 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.000157334968241163 0.000944673670072466 2.06020290964778 0.375 4.4 4 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000546039571248384 0.00277505110673732 2.06020290964778 0.375 4.4 4 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0265055605345056 0.0726794685123157 2.06020290964778 0.375 4.4 4 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0265055605345056 0.0726794685123157 2.06020290964778 0.375 4.4 4 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0265055605345056 0.0726794685123157 2.06020290964778 0.375 4.4 4 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.18061003003407e-08 7.80346219437668e-07 2.06020290964778 0.375 4.4 4 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.50283397757876e-13 1.18807375005255e-11 2.05653053369475 0.374331550802139 4.4 4 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 9.94475183935585e-06 9.18920900480739e-05 2.04995314392814 0.373134328358209 4.4 4 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 9.94475183935585e-06 9.18920900480739e-05 2.04995314392814 0.373134328358209 4.4 4 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.74935079582835e-08 4.78716573550721e-07 2.04771683140749 0.372727272727273 4.4 4 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.000115447908720171 0.000717390279951106 2.04673753115335 0.372549019607843 4.4 4 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00139954036517855 0.00628001655963228 2.0405819295559 0.371428571428571 4.4 4 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00139954036517855 0.00628001655963228 2.0405819295559 0.371428571428571 4.4 4 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.03251257392275e-12 2.04938049739003e-10 2.03596522835781 0.370588235294118 4.4 4 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.000291592659501793 0.00163360769476792 2.03034489646448 0.369565217391304 4.4 4 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000291592659501793 0.00163360769476792 2.03034489646448 0.369565217391304 4.4 4 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0187012116320518 0.055211253428236 2.0240589989522 0.368421052631579 4.4 4 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.79188292830327e-11 7.96827939679859e-10 2.02228506468494 0.368098159509202 4.4 4 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 9.83802283431054e-12 4.66650216440796e-10 2.01550422718994 0.366863905325444 4.4 4 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.45392179182083e-05 0.000205407688809473 1.99777251844633 0.363636363636364 4.4 4 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0132615176745128 0.0415651806678809 1.99777251844633 0.363636363636364 4.4 4 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0132615176745128 0.0415651806678809 1.99777251844633 0.363636363636364 4.4 4 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0132615176745128 0.0415651806678809 1.99777251844633 0.363636363636364 4.4 4 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.80670569889288e-09 1.17759613250534e-07 1.98275167244298 0.360902255639098 4.4 4 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00944321679164154 0.0316926827700611 1.97779479326187 0.36 4.4 4 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00944321679164154 0.0316926827700611 1.97779479326187 0.36 4.4 4 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.2256029731625e-06 5.67636109222156e-05 1.9669426956308 0.358024691358025 4.4 4 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.2256029731625e-06 5.67636109222156e-05 1.9669426956308 0.358024691358025 4.4 4 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000151788649030498 0.00092305661354871 1.96209800918836 0.357142857142857 4.4 4 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0515393033512789 0.123261224653563 1.96209800918836 0.357142857142857 4.4 4 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0515393033512789 0.123261224653563 1.96209800918836 0.357142857142857 4.4 4 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0515393033512789 0.123261224653563 1.96209800918836 0.357142857142857 4.4 4 4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0515393033512789 0.123261224653563 1.96209800918836 0.357142857142857 4.4 4 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0515393033512789 0.123261224653563 1.96209800918836 0.357142857142857 4.4 4 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.29813647406025e-14 2.04390512661733e-12 1.95704539628916 0.356223175965665 4.4 4 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.000716722633904242 0.00357858353700258 1.95337757359197 0.355555555555556 4.4 4 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.05290763136994e-08 9.56407467181996e-07 1.95236859757255 0.355371900826446 4.4 4 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.05290763136994e-08 9.56407467181996e-07 1.95236859757255 0.355371900826446 4.4 4 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.81978712419049e-07 2.90961469407087e-06 1.94782820548517 0.354545454545455 4.4 4 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 9.41493470293861e-06 9.11391298114398e-05 1.94719599899199 0.354430379746835 4.4 4 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 9.41493470293861e-06 9.11391298114398e-05 1.94719599899199 0.354430379746835 4.4 4 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 9.41493470293861e-06 9.11391298114398e-05 1.94719599899199 0.354430379746835 4.4 4 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 9.41493470293861e-06 9.11391298114398e-05 1.94719599899199 0.354430379746835 4.4 4 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000520381877958537 0.00267329751745487 1.94574719244513 0.354166666666667 4.4 4 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.06033020483384e-06 5.5820541716888e-05 1.93901450319791 0.352941176470588 4.4 4 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0357534813014018 0.0931816921096974 1.93901450319791 0.352941176470588 4.4 4 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0357534813014018 0.0931816921096974 1.93901450319791 0.352941176470588 4.4 4 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0357534813014018 0.0931816921096974 1.93901450319791 0.352941176470588 4.4 4 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0357534813014018 0.0931816921096974 1.93901450319791 0.352941176470588 4.4 4 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.1573472193312e-05 0.000248226800724215 1.93446282596036 0.352112676056338 4.4 4 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.75712367264771e-07 2.84134884792919e-06 1.92767523709734 0.350877192982456 4.4 4 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00180440684549991 0.00787629123051034 1.92285604900459 0.35 4.4 4 4 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0250301863920714 0.0699763364163412 1.92285604900459 0.35 4.4 4 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0250301863920714 0.0699763364163412 1.92285604900459 0.35 4.4 4 4 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0250301863920714 0.0699763364163412 1.92285604900459 0.35 4.4 4 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0250301863920714 0.0699763364163412 1.92285604900459 0.35 4.4 4 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.0755536183873e-06 1.37884035942804e-05 1.92285604900459 0.35 4.4 4 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.82721000741852e-09 6.04679032687571e-08 1.91399496122116 0.348387096774194 4.4 4 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000943458620252209 0.00450517321013051 1.91091284373127 0.347826086956522 4.4 4 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.000943458620252209 0.00450517321013051 1.91091284373127 0.347826086956522 4.4 4 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0176442967126354 0.0523680195169195 1.91091284373127 0.347826086956522 4.4 4 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.13393050562103e-05 0.000284182758912982 1.90759528671091 0.347222222222222 4.4 4 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.000683605160601195 0.00342524698427993 1.90603806606869 0.346938775510204 4.4 4 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 3.02018228097679e-05 0.000238762188101665 1.90454313425217 0.346666666666667 4.4 4 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 3.02018228097679e-05 0.000238762188101665 1.90454313425217 0.346666666666667 4.4 4 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 3.02018228097679e-05 0.000238762188101665 1.90454313425217 0.346666666666667 4.4 4 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 3.02018228097679e-05 0.000238762188101665 1.90454313425217 0.346666666666667 4.4 4 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 3.02018228097679e-05 0.000238762188101665 1.90454313425217 0.346666666666667 4.4 4 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 3.02018228097679e-05 0.000238762188101665 1.90454313425217 0.346666666666667 4.4 4 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000495903887178121 0.00257070144860945 1.9017257627518 0.346153846153846 4.4 4 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.0125052001623377 0.0408139904380884 1.9017257627518 0.346153846153846 4.4 4 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000261766836309 0.00148404066959246 1.89443945714738 0.344827586206897 4.4 4 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000261766836309 0.00148404066959246 1.89443945714738 0.344827586206897 4.4 4 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000261766836309 0.00148404066959246 1.89443945714738 0.344827586206897 4.4 4 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 8.64086371409555e-06 8.59856577983075e-05 1.89443945714738 0.344827586206897 4.4 4 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 8.64086371409555e-06 8.59856577983075e-05 1.89443945714738 0.344827586206897 4.4 4 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00635915386204807 0.022566274178789 1.8885193338438 0.34375 4.4 4 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.000101028431437324 0.000641801151496926 1.88595689241389 0.343283582089552 4.4 4 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.92265605480913e-05 0.000284182758912982 1.8794833561699 0.342105263157895 4.4 4 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000179367697351525 0.00106795076707623 1.8594651902462 0.338461538461538 4.4 4 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.41395900508566e-14 2.85768450837464e-12 1.85822223223133 0.338235294117647 4.4 4 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 9.51509221755613e-05 0.000607173821774995 1.85708431292194 0.338028169014085 4.4 4 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 5.64204604451613e-06 6.08229660708064e-05 1.84997812294903 0.336734693877551 4.4 4 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 6.39617951995158e-07 8.6683461494201e-06 1.8466804792361 0.336134453781513 4.4 4 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0229751873653753 0.0663700148329115 1.83129147524247 0.333333333333333 4.4 4 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.46878595123275e-08 4.09820080118471e-07 1.83129147524247 0.333333333333333 4.4 4 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.84525262224777e-05 0.000161091685979054 1.83129147524247 0.333333333333333 4.4 4 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00304076623691709 0.0122413721854797 1.83129147524247 0.333333333333333 4.4 4 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00304076623691709 0.0122413721854797 1.83129147524247 0.333333333333333 4.4 4 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0115443531386287 0.0379390635479644 1.83129147524247 0.333333333333333 4.4 4 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0326803287663671 0.0870863442594389 1.83129147524247 0.333333333333333 4.4 4 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0678133238871959 0.154150734650926 1.83129147524247 0.333333333333333 4.4 4 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0678133238871959 0.154150734650926 1.83129147524247 0.333333333333333 4.4 4 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0678133238871959 0.154150734650926 1.83129147524247 0.333333333333333 4.4 4 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0678133238871959 0.154150734650926 1.83129147524247 0.333333333333333 4.4 4 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.000122056730735236 0.000751890596693682 1.83129147524247 0.333333333333333 4.4 4 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000122056730735236 0.000751890596693682 1.83129147524247 0.333333333333333 4.4 4 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000167584466161091 0.00100198611490434 1.83129147524247 0.333333333333333 4.4 4 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.000316659233487123 0.0017198705696648 1.83129147524247 0.333333333333333 4.4 4 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00589228148296959 0.0212810064727557 1.83129147524247 0.333333333333333 4.4 4 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.0162476343186688 0.050152675998841 1.83129147524247 0.333333333333333 4.4 4 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0162476343186688 0.050152675998841 1.83129147524247 0.333333333333333 4.4 4 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0162476343186688 0.050152675998841 1.83129147524247 0.333333333333333 4.4 4 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0162476343186688 0.050152675998841 1.83129147524247 0.333333333333333 4.4 4 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0162476343186688 0.050152675998841 1.83129147524247 0.333333333333333 4.4 4 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0468385354715957 0.114718134210122 1.83129147524247 0.333333333333333 4.4 4 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0468385354715957 0.114718134210122 1.83129147524247 0.333333333333333 4.4 4 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0468385354715957 0.114718134210122 1.83129147524247 0.333333333333333 4.4 4 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0468385354715957 0.114718134210122 1.83129147524247 0.333333333333333 4.4 4 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.08010752488249e-15 1.09785214850556e-13 1.82005655821644 0.331288343558282 4.4 4 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.54459681597566e-08 6.58356594387886e-07 1.8196271983301 0.331210191082803 4.4 4 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.13476255425985e-24 5.06294519118629e-22 1.81071516653188 0.329588014981273 4.4 4 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 6.03069566283686e-05 0.000404796223029097 1.80895865237366 0.329268292682927 4.4 4 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 5.98369349518409e-08 1.33043685056984e-06 1.80719553477875 0.328947368421053 4.4 4 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.000113337584732324 0.000707365715237266 1.80719553477875 0.328947368421053 4.4 4 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000155518821621453 0.000937725776132746 1.80620529065011 0.328767123287671 4.4 4 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.000213547525711158 0.00124540216838926 1.80513016845329 0.328571428571429 4.4 4 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.000293451677481592 0.00163757543943649 1.80395876665676 0.328358208955224 4.4 4 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000403590277883483 0.00211922127464279 1.80267754594181 0.328125 4.4 4 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.3197358177488e-06 1.6189517833246e-05 1.80127030351718 0.327868852459016 4.4 4 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.97735284065543e-05 0.000238762188101665 1.79148079099807 0.326086956521739 4.4 4 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.00279524091711701 0.0115293560146594 1.79148079099807 0.326086956521739 4.4 4 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00279524091711701 0.0115293560146594 1.79148079099807 0.326086956521739 4.4 4 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00539477426702586 0.019583581076474 1.78550918836141 0.325 4.4 4 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000196868697676291 0.00116242388710939 1.78179711104673 0.324324324324324 4.4 4 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000196868697676291 0.00116242388710939 1.78179711104673 0.324324324324324 4.4 4 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 8.81059851610191e-08 1.81907366462423e-06 1.77333921336771 0.322784810126582 4.4 4 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000968094679047608 0.0046073536063035 1.76921379811561 0.322033898305085 4.4 4 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.020747634170761 0.0604997611167887 1.76588820826953 0.321428571428571 4.4 4 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.020747634170761 0.0604997611167887 1.76588820826953 0.321428571428571 4.4 4 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 9.90033998252067e-06 9.18920900480739e-05 1.76408811835284 0.321100917431193 4.4 4 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.50229972493929e-07 2.4572097799869e-06 1.76085718773314 0.320512820512821 4.4 4 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0293431735177206 0.0787836526711631 1.75803981623277 0.32 4.4 4 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0293431735177206 0.0787836526711631 1.75803981623277 0.32 4.4 4 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.000339853058495325 0.00183882472334163 1.75498766377403 0.319444444444444 4.4 4 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.68817275611998e-40 1.91263491597937e-37 1.75430024204909 0.319319319319319 4.4 4 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.58734421244602e-09 5.37807336740639e-08 1.75280755487494 0.319047619047619 4.4 4 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.000466715450603132 0.00243273291651376 1.75167010675367 0.318840579710145 4.4 4 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0417424406092324 0.106260273679674 1.74805095364054 0.318181818181818 4.4 4 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.26496809871963e-07 2.16873446322654e-06 1.74196018376723 0.317073170731707 4.4 4 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.00680537036169167 0.0236773643635385 1.74196018376723 0.317073170731707 4.4 4 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.00680537036169167 0.0236773643635385 1.74196018376723 0.317073170731707 4.4 4 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.189754347909e-06 1.47219168441261e-05 1.73906816353961 0.316546762589928 4.4 4 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.189754347909e-06 1.47219168441261e-05 1.73906816353961 0.316546762589928 4.4 4 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.61392258625378e-08 1.05896965165147e-06 1.73817495955218 0.31638418079096 4.4 4 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0598249926283085 0.139330547479677 1.7349077133876 0.315789473684211 4.4 4 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0598249926283085 0.139330547479677 1.7349077133876 0.315789473684211 4.4 4 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.08681455228391e-06 1.38083670348215e-05 1.72884160250163 0.314685314685315 4.4 4 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000109728553753283 0.000690901468986379 1.72840993168952 0.314606741573034 4.4 4 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000582750749511957 0.00295108297706589 1.72664624808576 0.314285714285714 4.4 4 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.0132399780291827 0.0415651806678809 1.72664624808576 0.314285714285714 4.4 4 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.0543321681394e-09 6.49625483391638e-08 1.72307879715996 0.313636363636364 4.4 4 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0865895799566007 0.189273382915888 1.71683575803982 0.3125 4.4 4 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0865895799566007 0.189273382915888 1.71683575803982 0.3125 4.4 4 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0865895799566007 0.189273382915888 1.71683575803982 0.3125 4.4 4 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.38009372264027e-33 1.55821834182928e-30 1.71528206052123 0.312217194570136 4.4 4 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.46134459800498e-08 1.41453744045555e-06 1.71120678834132 0.311475409836066 4.4 4 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00151293459113073 0.00666534341541496 1.71120678834132 0.311475409836066 4.4 4 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.00151293459113073 0.00666534341541496 1.71120678834132 0.311475409836066 4.4 4 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00151293459113073 0.00666534341541496 1.71120678834132 0.311475409836066 4.4 4 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.00611799481861183 0.0219292358359814 1.70920537689297 0.311111111111111 4.4 4 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 4.12628306666855e-11 1.63102800107482e-09 1.70567942459407 0.310469314079422 4.4 4 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0260783603349396 0.0726794685123157 1.70499551143265 0.310344827586207 4.4 4 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00287092272835752 0.0117057966832457 1.69810664067938 0.309090909090909 4.4 4 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00287092272835752 0.0117057966832457 1.69810664067938 0.309090909090909 4.4 4 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.71449101875135e-18 3.51156429062107e-16 1.69729453802961 0.308943089430894 4.4 4 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000347678146597687 0.00187403788866859 1.69564025485414 0.308641975308642 4.4 4 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.00136179280833124 0.00619959138030042 1.69042290022382 0.307692307692308 4.4 4 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0368267172312242 0.094888321799404 1.69042290022382 0.307692307692308 4.4 4 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.77667088229481e-06 4.23165564213033e-05 1.68740428790199 0.307142857142857 4.4 4 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.77667088229481e-06 4.23165564213033e-05 1.68740428790199 0.307142857142857 4.4 4 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.047002568117e-05 9.61215906084187e-05 1.68709529608952 0.307086614173228 4.4 4 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000229337086696146 0.00133202724232088 1.68562056243909 0.306818181818182 4.4 4 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000313186026166285 0.00171088633668248 1.68047923610486 0.305882352941176 4.4 4 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000313186026166285 0.00171088633668248 1.68047923610486 0.305882352941176 4.4 4 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000313186026166285 0.00171088633668248 1.68047923610486 0.305882352941176 4.4 4 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000313186026166285 0.00171088633668248 1.68047923610486 0.305882352941176 4.4 4 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000313186026166285 0.00171088633668248 1.68047923610486 0.305882352941176 4.4 4 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.0164729645095164 0.0505194579677625 1.6786838523056 0.305555555555556 4.4 4 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.0164729645095164 0.0505194579677625 1.6786838523056 0.305555555555556 4.4 4 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0522853785639936 0.124835727678797 1.67204873826486 0.304347826086957 4.4 4 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0230321845103582 0.0663700148329115 1.66481043203861 0.303030303030303 4.4 4 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0104921987670708 0.0347218577803298 1.66093877987108 0.302325581395349 4.4 4 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.00229784400356398 0.00987864657725541 1.65688276331462 0.301587301587302 4.4 4 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.24384000433526e-06 2.66401145632903e-05 1.64816232771822 0.3 4.4 4 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.03230722056193 0.0862536113689051 1.64816232771822 0.3 4.4 4 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0747370524438385 0.167306186613608 1.64816232771822 0.3 4.4 4 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0747370524438385 0.167306186613608 1.64816232771822 0.3 4.4 4 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0747370524438385 0.167306186613608 1.64816232771822 0.3 4.4 4 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0747370524438385 0.167306186613608 1.64816232771822 0.3 4.4 4 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0747370524438385 0.167306186613608 1.64816232771822 0.3 4.4 4 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.00928644549037174 0.0313142462862535 1.6364732331954 0.297872340425532 4.4 4 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.00280364720531524 0.0115306068588543 1.63099397013783 0.296875 4.4 4 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 4.97463352539907e-06 5.53039336456474e-05 1.63044015215136 0.296774193548387 4.4 4 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0059580302301876 0.0214097904483761 1.62781464465997 0.296296296296296 4.4 4 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.0059580302301876 0.0214097904483761 1.62781464465997 0.296296296296296 4.4 4 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.045491594247037 0.113442355395595 1.62781464465997 0.296296296296296 4.4 4 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.045491594247037 0.113442355395595 1.62781464465997 0.296296296296296 4.4 4 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0128388294291682 0.0414827054496109 1.62319017123764 0.295454545454545 4.4 4 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.0128388294291682 0.0414827054496109 1.62319017123764 0.295454545454545 4.4 4 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.0128388294291682 0.0414827054496109 1.62319017123764 0.295454545454545 4.4 4 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.0038415720816098 0.0146950458928246 1.62114327316547 0.295081967213115 4.4 4 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00248690103930255 0.0105323219610938 1.61584541933159 0.294117647058824 4.4 4 4 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.1077712877296 0.227541052957375 1.61584541933159 0.294117647058824 4.4 4 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.1077712877296 0.227541052957375 1.61584541933159 0.294117647058824 4.4 4 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.1077712877296 0.227541052957375 1.61584541933159 0.294117647058824 4.4 4 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.1077712877296 0.227541052957375 1.61584541933159 0.294117647058824 4.4 4 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.1077712877296 0.227541052957375 1.61584541933159 0.294117647058824 4.4 4 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00526663289088054 0.019340996547092 1.61027353857528 0.293103448275862 4.4 4 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00526663289088054 0.019340996547092 1.61027353857528 0.293103448275862 4.4 4 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 9.22671678397516e-07 1.19360163487242e-05 1.60238004083716 0.291666666666667 4.4 4 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0112922841667807 0.0371965749290022 1.60238004083716 0.291666666666667 4.4 4 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0643542808222482 0.148181458915953 1.60238004083716 0.291666666666667 4.4 4 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.007224535871964 0.024952705208264 1.59821801475707 0.290909090909091 4.4 4 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.61665111858352e-07 5.376000575301e-06 1.59583971413987 0.29047619047619 4.4 4 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00464774277620266 0.0173588923111191 1.59499580101764 0.290322580645161 4.4 4 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.24653109458527e-06 2.66401145632903e-05 1.59112210144018 0.289617486338798 4.4 4 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0246530105205128 0.0694677900409697 1.5903320706053 0.289473684210526 4.4 4 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00635710496854385 0.022566274178789 1.58298076673502 0.288135593220339 4.4 4 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.00172060778679168 0.00753361501724479 1.57948889739663 0.2875 4.4 4 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.00027724646576576 0.00156556238406618 1.56967840735069 0.285714285714286 4.4 4 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.00869820094986894 0.029540668142395 1.56967840735069 0.285714285714286 4.4 4 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0136200761407877 0.0425030007639054 1.56967840735069 0.285714285714286 4.4 4 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0342531500337913 0.0911069766319346 1.56967840735069 0.285714285714286 4.4 4 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.091559741914827 0.197408352643634 1.56967840735069 0.285714285714286 4.4 4 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.091559741914827 0.197408352643634 1.56967840735069 0.285714285714286 4.4 4 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 5.54730507928367e-08 1.2529865282255e-06 1.56364118270703 0.284615384615385 4.4 4 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.00762327754797089 0.0262027148569144 1.5565977539561 0.283333333333333 4.4 4 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00762327754797089 0.0262027148569144 1.5565977539561 0.283333333333333 4.4 4 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0119055899999299 0.0389463323445984 1.55487012048889 0.283018867924528 4.4 4 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0119055899999299 0.0389463323445984 1.55487012048889 0.283018867924528 4.4 4 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0476905924109709 0.11660431787081 1.54515218223583 0.28125 4.4 4 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000915162130415977 0.0044598483273354 1.53828483920368 0.28 4.4 4 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0163011599372704 0.0502089839626315 1.53828483920368 0.28 4.4 4 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0779697114406757 0.172284005248574 1.53828483920368 0.28 4.4 4 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0779697114406757 0.172284005248574 1.53828483920368 0.28 4.4 4 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0779697114406757 0.172284005248574 1.53828483920368 0.28 4.4 4 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00331284611340014 0.0129867218164419 1.52993971349371 0.278481012658228 4.4 4 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 3.26802303686788e-16 3.57722829343307e-14 1.52939894588679 0.278382581648523 4.4 4 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.131206961674987 0.256466355032288 1.52607622936873 0.277777777777778 4.4 4 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.131206961674987 0.256466355032288 1.52607622936873 0.277777777777778 4.4 4 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.131206961674987 0.256466355032288 1.52607622936873 0.277777777777778 4.4 4 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.131206961674987 0.256466355032288 1.52607622936873 0.277777777777778 4.4 4 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.0223265139687266 0.064705966145617 1.51958228796716 0.276595744680851 4.4 4 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.22689758766217e-19 8.86087526724327e-17 1.51943261966341 0.276568501920615 4.4 4 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 0.000359657890392995 0.00191223204058953 1.51863195507912 0.276422764227642 4.4 4 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00447690838950158 0.0168535466620655 1.51804424921415 0.276315789473684 4.4 4 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0665552041604456 0.152754928258571 1.51555156571791 0.275862068965517 4.4 4 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0665552041604456 0.152754928258571 1.51555156571791 0.275862068965517 4.4 4 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0569374953737006 0.133041142720486 1.49832938883475 0.272727272727273 4.4 4 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.0569374953737006 0.133041142720486 1.49832938883475 0.272727272727273 4.4 4 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.0168063294069156 0.0511012964658992 1.49832938883475 0.272727272727273 4.4 4 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0168063294069156 0.0511012964658992 1.49832938883475 0.272727272727273 4.4 4 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0168063294069156 0.0511012964658992 1.49832938883475 0.272727272727273 4.4 4 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.0168063294069156 0.0511012964658992 1.49832938883475 0.272727272727273 4.4 4 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00460984510700235 0.0172626568085904 1.49216342427164 0.271604938271605 4.4 4 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00460984510700235 0.0172626568085904 1.49216342427164 0.271604938271605 4.4 4 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00816263961273554 0.0279890028166812 1.49119448698315 0.271428571428571 4.4 4 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.000435683813445393 0.0022793311269588 1.49058608449969 0.271317829457364 4.4 4 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.2113466256026e-10 4.65877364387162e-09 1.49049059532067 0.271300448430493 4.4 4 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.22885442439374e-05 0.000191843579659518 1.48792432363451 0.270833333333333 4.4 4 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0488068266246735 0.118924853231011 1.48483092587227 0.27027027027027 4.4 4 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0488068266246735 0.118924853231011 1.48483092587227 0.27027027027027 4.4 4 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0931276566757368 0.200182258987271 1.47912003769584 0.269230769230769 4.4 4 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.00470935781157729 0.0175429742562159 1.46929199757826 0.267441860465116 4.4 4 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000593228981996835 0.00298291463385688 1.46782904504167 0.267175572519084 4.4 4 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000593228981996835 0.00298291463385688 1.46782904504167 0.267175572519084 4.4 4 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0672652145308276 0.153888103339819 1.45426087739843 0.264705882352941 4.4 4 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.1567005220488 0.295344162748931 1.445756427823 0.263157894736842 4.4 4 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.1567005220488 0.295344162748931 1.445756427823 0.263157894736842 4.4 4 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 6.56661671688182e-06 6.86078132894982e-05 1.4388718734048 0.261904761904762 4.4 4 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 6.56661671688182e-06 6.86078132894982e-05 1.4388718734048 0.261904761904762 4.4 4 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 6.56661671688182e-06 6.86078132894982e-05 1.4388718734048 0.261904761904762 4.4 4 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.130696236259871 0.256466355032288 1.43318463279846 0.260869565217391 4.4 4 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.130696236259871 0.256466355032288 1.43318463279846 0.260869565217391 4.4 4 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0362305675683155 0.0942524637106271 1.42840735068913 0.26 4.4 4 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.109800278525782 0.231132834825721 1.42433781407748 0.259259259259259 4.4 4 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.109800278525782 0.231132834825721 1.42433781407748 0.259259259259259 4.4 4 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0927532891919576 0.199679168714305 1.41777404534901 0.258064516129032 4.4 4 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.00140340496553975 0.00628001655963228 1.41508886723282 0.257575757575758 4.4 4 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.00366979005024196 0.0140757715404159 1.41127049468227 0.256880733944954 4.4 4 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0129892979532933 0.0415651806678809 1.40868575018652 0.256410256410256 4.4 4 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0669974413842472 0.153522317374853 1.40868575018652 0.256410256410256 4.4 4 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00976869173648296 0.0324029098858165 1.40540973681399 0.255813953488372 4.4 4 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 0.000243717710630738 0.00140409029241919 1.40332661961515 0.255434782608696 4.4 4 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00122708510848361 0.00568775931391589 1.40269134273891 0.25531914893617 4.4 4 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.00554426823047047 0.0200750475622379 1.38630476163215 0.252336448598131 4.4 4 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00106562643695527 0.00497175875340112 1.38232969421528 0.251612903225806 4.4 4 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00362927034511891 0.014072075479848 1.37346860643185 0.25 4.4 4 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0307472016851316 0.0822429849585382 1.37346860643185 0.25 4.4 4 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.0357070563047929 0.0931816921096974 1.37346860643185 0.25 4.4 4 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.0357070563047929 0.0931816921096974 1.37346860643185 0.25 4.4 4 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0357070563047929 0.0931816921096974 1.37346860643185 0.25 4.4 4 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.0357070563047929 0.0931816921096974 1.37346860643185 0.25 4.4 4 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.0357070563047929 0.0931816921096974 1.37346860643185 0.25 4.4 4 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.0357070563047929 0.0931816921096974 1.37346860643185 0.25 4.4 4 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.0357070563047929 0.0931816921096974 1.37346860643185 0.25 4.4 4 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0564790339438141 0.132404720431709 1.37346860643185 0.25 4.4 4 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.107774188118953 0.227541052957375 1.37346860643185 0.25 4.4 4 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.152810221405746 0.291008743393754 1.37346860643185 0.25 4.4 4 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.152810221405746 0.291008743393754 1.37346860643185 0.25 4.4 4 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.152810221405746 0.291008743393754 1.37346860643185 0.25 4.4 4 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.152810221405746 0.291008743393754 1.37346860643185 0.25 4.4 4 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.184021678583787 0.335721600800935 1.37346860643185 0.25 4.4 4 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.184021678583787 0.335721600800935 1.37346860643185 0.25 4.4 4 4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.184021678583787 0.335721600800935 1.37346860643185 0.25 4.4 4 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0912260625253597 0.197286758318521 1.37346860643185 0.25 4.4 4 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0912260625253597 0.197286758318521 1.37346860643185 0.25 4.4 4 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.12793731194186 0.25215345553084 1.37346860643185 0.25 4.4 4 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000357164150916447 0.00191134682083218 1.36649668457179 0.248730964467005 4.4 4 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00120292061712406 0.00559397398093967 1.36493774552234 0.248447204968944 4.4 4 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00272935102660686 0.0113232259791882 1.36344328813673 0.248175182481752 4.4 4 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00474184456215433 0.0176178715716596 1.36211762621341 0.247933884297521 4.4 4 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00829283175054109 0.0282990397626378 1.36038795303726 0.247619047619048 4.4 4 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.0168919075422551 0.0511429456013384 1.35731015223854 0.247058823529412 4.4 4 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.0168919075422551 0.0511429456013384 1.35731015223854 0.247058823529412 4.4 4 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00136364870135912 0.00619959138030042 1.35651220388331 0.246913580246914 4.4 4 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.019518006189608 0.0571484008391198 1.35651220388331 0.246913580246914 4.4 4 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0302852979133146 0.0811600356509354 1.35356326430965 0.246376811594203 4.4 4 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.0221816920001949 0.0645491773339005 1.33996937212864 0.24390243902439 4.4 4 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0890035737784864 0.193361962575246 1.33996937212864 0.24390243902439 4.4 4 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0890035737784864 0.193361962575246 1.33996937212864 0.24390243902439 4.4 4 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0890035737784864 0.193361962575246 1.33996937212864 0.24390243902439 4.4 4 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.0890035737784864 0.193361962575246 1.33996937212864 0.24390243902439 4.4 4 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.104860816922009 0.223378656407213 1.33634783328505 0.243243243243243 4.4 4 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.104860816922009 0.223378656407213 1.33634783328505 0.243243243243243 4.4 4 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00395513044010697 0.0150888756468424 1.33422664624809 0.242857142857143 4.4 4 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 7.80843906338627e-21 1.58734411245695e-18 1.33356796905972 0.242737249838606 4.4 4 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.124041929797434 0.248958626377643 1.33184834563089 0.242424242424242 4.4 4 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.124041929797434 0.248958626377643 1.33184834563089 0.242424242424242 4.4 4 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00257767325918863 0.0107252311339925 1.32972756801046 0.24203821656051 4.4 4 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0464659544940792 0.114594546351949 1.3291631675147 0.241935483870968 4.4 4 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.147467982599582 0.286285046711058 1.32610762000317 0.241379310344828 4.4 4 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.176444066657873 0.323140163261458 1.31852986217458 0.24 4.4 4 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.176444066657873 0.323140163261458 1.31852986217458 0.24 4.4 4 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.176444066657873 0.323140163261458 1.31852986217458 0.24 4.4 4 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00284102782791309 0.0116506703144678 1.31448529204521 0.239263803680982 4.4 4 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00325459161234441 0.0127936018352655 1.31300143507951 0.238993710691824 4.4 4 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00325459161234441 0.0127936018352655 1.31300143507951 0.238993710691824 4.4 4 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.212916033792838 0.379673579056652 1.30806533945891 0.238095238095238 4.4 4 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.212916033792838 0.379673579056652 1.30806533945891 0.238095238095238 4.4 4 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0238846677368443 0.0674362741855743 1.29962620823659 0.236559139784946 4.4 4 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0439843855086152 0.111767465319213 1.29716479496342 0.236111111111111 4.4 4 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.28191299794156e-05 0.000194440850064122 1.29267633546527 0.235294117647059 4.4 4 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00827546604294775 0.0282990397626378 1.29267633546527 0.235294117647059 4.4 4 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.141511688341005 0.275097175559085 1.29267633546527 0.235294117647059 4.4 4 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.141511688341005 0.275097175559085 1.29267633546527 0.235294117647059 4.4 4 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00923924652922209 0.0312290921878457 1.28324074177575 0.233576642335766 4.4 4 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.03720180752007e-07 5.86218180826639e-06 1.27965901685069 0.23292469352014 4.4 4 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00897930808136916 0.0304227509518769 1.27674546513384 0.232394366197183 4.4 4 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.135354424087303 0.263848418460592 1.26781717516786 0.230769230769231 4.4 4 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.135354424087303 0.263848418460592 1.26781717516786 0.230769230769231 4.4 4 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.201438989652514 0.360110153612471 1.26781717516786 0.230769230769231 4.4 4 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.201438989652514 0.360110153612471 1.26781717516786 0.230769230769231 4.4 4 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.201438989652514 0.360110153612471 1.26781717516786 0.230769230769231 4.4 4 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.110075011958827 0.23136889515127 1.2590128892292 0.229166666666667 4.4 4 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0443742117063804 0.112557046806024 1.24860782402896 0.227272727272727 4.4 4 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.243114505524724 0.417312353874164 1.24860782402896 0.227272727272727 4.4 4 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.190338745839966 0.341984893093778 1.24055228968038 0.225806451612903 4.4 4 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.123202172855446 0.247972690202687 1.23331874863268 0.224489795918367 4.4 4 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 0.00346985457215801 0.0135648435609364 1.23181040935592 0.224215246636771 4.4 4 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.117386417555483 0.236601801956731 1.22086098349498 0.222222222222222 4.4 4 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.227621478545866 0.401073192488108 1.22086098349498 0.222222222222222 4.4 4 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.169904433164463 0.31695926339855 1.20597243491577 0.219512195121951 4.4 4 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.169904433164463 0.31695926339855 1.20597243491577 0.219512195121951 4.4 4 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.169904433164463 0.31695926339855 1.20597243491577 0.219512195121951 4.4 4 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.169904433164463 0.31695926339855 1.20597243491577 0.219512195121951 4.4 4 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0459190419591445 0.113442355395595 1.1986635110678 0.218181818181818 4.4 4 4 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.274341802542738 0.463899757490892 1.19432052733205 0.217391304347826 4.4 4 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.274341802542738 0.463899757490892 1.19432052733205 0.217391304347826 4.4 4 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.00535634382079656 0.0194938037263261 1.18495330750983 0.215686274509804 4.4 4 4 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.254808069437867 0.434762449412572 1.17725880551302 0.214285714285714 4.4 4 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.254808069437867 0.434762449412572 1.17725880551302 0.214285714285714 4.4 4 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.254808069437867 0.434762449412572 1.17725880551302 0.214285714285714 4.4 4 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.254808069437867 0.434762449412572 1.17725880551302 0.214285714285714 4.4 4 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0793400291432378 0.174229724492018 1.16890945228243 0.212765957446809 4.4 4 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0910150460618381 0.197286758318521 1.15981793432023 0.211111111111111 4.4 4 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.000496797539260434 0.00257070144860945 1.15426856621344 0.21010101010101 4.4 4 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.195363792651937 0.350570841038722 1.14455717202654 0.208333333333333 4.4 4 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.306323797578789 0.491430399046919 1.14455717202654 0.208333333333333 4.4 4 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.282809831221768 0.463899757490892 1.13666367428843 0.206896551724138 4.4 4 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.262423714695475 0.445619267317018 1.13109179353211 0.205882352941176 4.4 4 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.244436604517676 0.419076250877895 1.12694860014921 0.205128205128205 4.4 4 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.149179940893453 0.287425310738502 1.11268342799543 0.20253164556962 4.4 4 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.218312886237854 0.388810058969295 1.09877488514548 0.2 4.4 4 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.233044174880836 0.401073192488108 1.09877488514548 0.2 4.4 4 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.311436458990896 0.498508527721086 1.09877488514548 0.2 4.4 4 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.311436458990896 0.498508527721086 1.09877488514548 0.2 4.4 4 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.184463983038184 0.336097628506192 1.08431732086725 0.197368421052632 4.4 4 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.221745677147841 0.394430123226722 1.08076218211031 0.19672131147541 4.4 4 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.270917941471451 0.459494911458731 1.07488847459884 0.195652173913043 4.4 4 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.340499910147119 0.53976678425198 1.06333053401176 0.193548387096774 4.4 4 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.340499910147119 0.53976678425198 1.06333053401176 0.193548387096774 4.4 4 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.371497239989138 0.575534702360334 1.05651431263989 0.192307692307692 4.4 4 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.371497239989138 0.575534702360334 1.05651431263989 0.192307692307692 4.4 4 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.103658408589032 0.221480353486776 1.05405730261049 0.191860465116279 4.4 4 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.315311994897187 0.503579089493488 1.04645227156713 0.19047619047619 4.4 4 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.315311994897187 0.503579089493488 1.04645227156713 0.19047619047619 4.4 4 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.340625841362107 0.53976678425198 1.03938164811059 0.189189189189189 4.4 4 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.174216966810629 0.320298118567863 1.03573042452238 0.188524590163934 4.4 4 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.369817545872951 0.575137013964162 1.03010145482389 0.1875 4.4 4 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.367398598816722 0.573727264935168 1.0120294994761 0.184210526315789 4.4 4 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.399214764464554 0.604343201950064 0.998886259223166 0.181818181818182 4.4 4 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.291697810259881 0.473132617158432 0.992868872119412 0.180722891566265 4.4 4 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.44795954645136 0.665392937996122 0.937978560490046 0.170731707317073 4.4 4 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.431634353340212 0.641813672730535 0.932922072293334 0.169811320754717 4.4 4 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.500184612562274 0.715339400679514 0.915645737621235 0.166666666666667 4.4 4 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0758038536519931 0.168282189932584 0.908499234303216 0.165365853658537 4.4 4 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.397874883407482 0.602956292959369 0.908435928663588 0.165354330708661 4.4 4 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.530893209180573 0.74946531415075 0.886108778343131 0.161290322580645 4.4 4 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.411817979117012 0.616692176814677 0.882550108550588 0.160642570281124 4.4 4 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.533100361433985 0.751835296650705 0.858417879019908 0.15625 4.4 4 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.589562619871606 0.809794988491597 0.832405216019305 0.151515151515152 4.4 4 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.589562619871606 0.809794988491597 0.832405216019305 0.151515151515152 4.4 4 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.582907349172117 0.80220228034035 0.829264064260741 0.150943396226415 4.4 4 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.609896020855728 0.836916140479944 0.810571636582733 0.147540983606557 4.4 4 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.614583599150619 0.839022762194487 0.809623599580882 0.147368421052632 4.4 4 4 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.61732735911288 0.839022762194487 0.807922709665796 0.147058823529412 4.4 4 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.623441692790652 0.845717377350903 0.801190020418581 0.145833333333333 4.4 4 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.623441692790652 0.845717377350903 0.801190020418581 0.145833333333333 4.4 4 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.645900924181776 0.864644416849169 0.784839203675345 0.142857142857143 4.4 4 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.673823387406283 0.893616663820261 0.775605801279164 0.141176470588235 4.4 4 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.673823387406283 0.893616663820261 0.775605801279164 0.141176470588235 4.4 4 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.724223937181994 0.948960094484325 0.772112081453582 0.140540540540541 4.4 4 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.688790510470454 0.906420434265135 0.764969856746855 0.139240506329114 4.4 4 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.74769578759931 0.965313725264083 0.739560018847921 0.134615384615385 4.4 4 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.74823685099528 0.965313725264083 0.736292448808828 0.134020618556701 4.4 4 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.849373529610543 1 0.703483920367534 0.128048780487805 4.4 4 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.873842467568807 1 0.619028104307314 0.112676056338028 4.4 4 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.843161243961242 1 0.61043049174749 0.111111111111111 4.4 4 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.858088995821524 1 0.61043049174749 0.111111111111111 4.4 4 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.973497894849466 1 0.607617448006718 0.110599078341014 4.4 4 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.989755607633046 1 0.581704350959373 0.105882352941176 4.4 4 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.976568311698249 1 0.499443129611583 0.0909090909090909 4.4 4 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99993010919265 1 0.495581455929019 0.0902061855670103 4.4 4 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.99790845573622 1 0.47259134844967 0.0860215053763441 4.4 4 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999889642349316 1 0.451282542113323 0.0821428571428571 4.4 4 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999999991 1 0.447444012842619 0.0814441645675903 4.4 4 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.36758291817706 0.0669077757685353 4.4 4 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.99999505828493 1 0.280936760406515 0.0511363636363636 4.4 4 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999896855610123 1 0.254346038228121 0.0462962962962963 4.4 4 4 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.000965490209761557 0.00291696935985286 1.38146718146718 1 5.3 5 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000965490209761557 0.00291696935985286 1.38146718146718 1 5.3 5 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000965490209761557 0.00291696935985286 1.38146718146718 1 5.3 5 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 5.27916798909588e-06 2.74677795610325e-05 1.38146718146718 1 5.3 5 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 5.27916798909588e-06 2.74677795610325e-05 1.38146718146718 1 5.3 5 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 5.27916798909588e-06 2.74677795610325e-05 1.38146718146718 1 5.3 5 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 5.27916798909588e-06 2.74677795610325e-05 1.38146718146718 1 5.3 5 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 2.99707145915372e-05 0.000132038163664884 1.38146718146718 1 5.3 5 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 2.99707145915372e-05 0.000132038163664884 1.38146718146718 1 5.3 5 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 2.99707145915372e-05 0.000132038163664884 1.38146718146718 1 5.3 5 3 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.000405286122077347 0.00134052038982436 1.38146718146718 1 5.3 5 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000405286122077347 0.00134052038982436 1.38146718146718 1 5.3 5 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.000405286122077347 0.00134052038982436 1.38146718146718 1 5.3 5 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000405286122077347 0.00134052038982436 1.38146718146718 1 5.3 5 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00229993899736499 0.00628179115787022 1.38146718146718 1 5.3 5 3 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00229993899736499 0.00628179115787022 1.38146718146718 1 5.3 5 3 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00229993899736499 0.00628179115787022 1.38146718146718 1 5.3 5 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00547856808151034 0.013146715649223 1.38146718146718 1 5.3 5 3 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00547856808151034 0.013146715649223 1.38146718146718 1 5.3 5 3 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00547856808151034 0.013146715649223 1.38146718146718 1 5.3 5 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00547856808151034 0.013146715649223 1.38146718146718 1 5.3 5 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 1.25788269869471e-05 6.13002424740605e-05 1.38146718146718 1 5.3 5 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000170120985814333 0.000632068310218788 1.38146718146718 1 5.3 5 3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.000170120985814333 0.000632068310218788 1.38146718146718 1 5.3 5 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.000170120985814333 0.000632068310218788 1.38146718146718 1 5.3 5 3 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%REACT_208690.1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%REACT_209262.1 CLEAVAGE OF THE DAMAGED PYRIMIDINE 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%REACT_215995.1 NOSTRIN MEDIATED ENOS TRAFFICKING 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605564 MUSCARINIC ACETYLCHOLINE RECEPTORS 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 DEPYRIMIDINATION%REACTOME%REACT_206945.1 DEPYRIMIDINATION 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0130496875531425 0.0276746727095705 1.38146718146718 1 5.3 5 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 2.06843506799376e-10 2.80322200167154e-09 1.33541827541828 0.966666666666667 5.3 5 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.33340957510983e-08 1.12942965796505e-07 1.32620849420849 0.96 5.3 5 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 3.05480010658633e-08 2.41498919537352e-07 1.32390604890605 0.958333333333333 5.3 5 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 3.6342473154311e-07 2.43940279710304e-06 1.31568302996874 0.952380952380952 5.3 5 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 1.8740800624758e-06 1.1252387885667e-05 1.30875838244259 0.947368421052632 5.3 5 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 4.23959555427865e-06 2.30265056249562e-05 1.304719004719 0.944444444444444 5.3 5 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 2.15019621424402e-05 9.83835759765031e-05 1.29512548262548 0.9375 5.3 5 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 2.15019621424402e-05 9.83835759765031e-05 1.29512548262548 0.9375 5.3 5 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 2.15019621424402e-05 9.83835759765031e-05 1.29512548262548 0.9375 5.3 5 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 2.15019621424402e-05 9.83835759765031e-05 1.29512548262548 0.9375 5.3 5 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000107474393959012 0.000422258469694058 1.28279095421953 0.928571428571429 5.3 5 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 1.03608204643171e-07 7.56934616994228e-07 1.27520047520048 0.923076923076923 5.3 5 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 1.03608204643171e-07 7.56934616994228e-07 1.27520047520048 0.923076923076923 5.3 5 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000238673365846619 0.000824349999028492 1.27520047520048 0.923076923076923 5.3 5 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000238673365846619 0.000824349999028492 1.27520047520048 0.923076923076923 5.3 5 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000238673365846619 0.000824349999028492 1.27520047520048 0.923076923076923 5.3 5 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000527197376763964 0.00168584689243847 1.26634491634492 0.916666666666667 5.3 5 3 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.000527197376763964 0.00168584689243847 1.26634491634492 0.916666666666667 5.3 5 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.000527197376763964 0.00168584689243847 1.26634491634492 0.916666666666667 5.3 5 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000527197376763964 0.00168584689243847 1.26634491634492 0.916666666666667 5.3 5 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.000527197376763964 0.00168584689243847 1.26634491634492 0.916666666666667 5.3 5 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000527197376763964 0.00168584689243847 1.26634491634492 0.916666666666667 5.3 5 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000527197376763964 0.00168584689243847 1.26634491634492 0.916666666666667 5.3 5 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00115726814623193 0.00340950843082411 1.25587925587926 0.909090909090909 5.3 5 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00115726814623193 0.00340950843082411 1.25587925587926 0.909090909090909 5.3 5 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00115726814623193 0.00340950843082411 1.25587925587926 0.909090909090909 5.3 5 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 5.22318768659902e-06 2.74677795610325e-05 1.24989887847031 0.904761904761905 5.3 5 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 2.6225050146942e-08 2.10837550051404e-07 1.24777680906713 0.903225806451613 5.3 5 3 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.00252177234844447 0.00678351994676083 1.24332046332046 0.9 5.3 5 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00252177234844447 0.00678351994676083 1.24332046332046 0.9 5.3 5 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00252177234844447 0.00678351994676083 1.24332046332046 0.9 5.3 5 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 1.21831660911835e-07 8.71188208429852e-07 1.23855678338437 0.896551724137931 5.3 5 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 2.4346477234603e-05 0.000109636193369747 1.236049583418 0.894736842105263 5.3 5 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 2.4346477234603e-05 0.000109636193369747 1.236049583418 0.894736842105263 5.3 5 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 2.61188374114013e-07 1.7955123495857e-06 1.2334528405957 0.892857142857143 5.3 5 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 7.21971299328742e-11 1.23778934812626e-09 1.22797082797083 0.888888888888889 5.3 5 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 5.21518824509739e-05 0.000218270966846282 1.22797082797083 0.888888888888889 5.3 5 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 5.21518824509739e-05 0.000218270966846282 1.22797082797083 0.888888888888889 5.3 5 3 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.00544712291123524 0.013146715649223 1.22797082797083 0.888888888888889 5.3 5 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00544712291123524 0.013146715649223 1.22797082797083 0.888888888888889 5.3 5 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00544712291123524 0.013146715649223 1.22797082797083 0.888888888888889 5.3 5 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00544712291123524 0.013146715649223 1.22797082797083 0.888888888888889 5.3 5 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00544712291123524 0.013146715649223 1.22797082797083 0.888888888888889 5.3 5 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00544712291123524 0.013146715649223 1.22797082797083 0.888888888888889 5.3 5 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00544712291123524 0.013146715649223 1.22797082797083 0.888888888888889 5.3 5 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.5340651805866e-10 2.26585431488288e-09 1.22448227448227 0.886363636363636 5.3 5 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.18607233667809e-06 7.30641097442821e-06 1.22206712206712 0.884615384615385 5.3 5 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.000111042805806406 0.000428221985535272 1.21894163070634 0.882352941176471 5.3 5 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000111042805806406 0.000428221985535272 1.21894163070634 0.882352941176471 5.3 5 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.000111042805806406 0.000428221985535272 1.21894163070634 0.882352941176471 5.3 5 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000111042805806406 0.000428221985535272 1.21894163070634 0.882352941176471 5.3 5 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 5.9483152954726e-08 4.50236843907314e-07 1.21401661401661 0.878787878787879 5.3 5 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.19764907450744e-15 4.48488061322129e-14 1.20878378378378 0.875 5.3 5 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.25046318401663e-07 8.89704555427831e-07 1.20878378378378 0.875 5.3 5 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 5.28894701315734e-06 2.74677795610325e-05 1.20878378378378 0.875 5.3 5 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 5.28894701315734e-06 2.74677795610325e-05 1.20878378378378 0.875 5.3 5 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.000234849648668879 0.000817093031921309 1.20878378378378 0.875 5.3 5 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000234849648668879 0.000817093031921309 1.20878378378378 0.875 5.3 5 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.000234849648668879 0.000817093031921309 1.20878378378378 0.875 5.3 5 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.011641080510589 0.0254458641575548 1.20878378378378 0.875 5.3 5 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.011641080510589 0.0254458641575548 1.20878378378378 0.875 5.3 5 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.011641080510589 0.0254458641575548 1.20878378378378 0.875 5.3 5 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.011641080510589 0.0254458641575548 1.20878378378378 0.875 5.3 5 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.011641080510589 0.0254458641575548 1.20878378378378 0.875 5.3 5 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.011641080510589 0.0254458641575548 1.20878378378378 0.875 5.3 5 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.011641080510589 0.0254458641575548 1.20878378378378 0.875 5.3 5 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.011641080510589 0.0254458641575548 1.20878378378378 0.875 5.3 5 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.57036963096081e-10 2.26585431488288e-09 1.20510966893946 0.872340425531915 5.3 5 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.81267540876264e-10 6.82706838497833e-09 1.19727155727156 0.866666666666667 5.3 5 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000492950205464 0.00160519025715165 1.19727155727156 0.866666666666667 5.3 5 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 2.75409632335296e-08 2.20172981355689e-07 1.19478242721486 0.864864864864865 5.3 5 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 2.30867548995896e-05 0.000105168529296372 1.19308529308529 0.863636363636364 5.3 5 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.01068445303642e-13 5.96084161806421e-12 1.19018711018711 0.861538461538462 5.3 5 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 5.69944442104899e-08 4.33706385623139e-07 1.18959673959674 0.861111111111111 5.3 5 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.33718300823832e-06 1.37430223996823e-05 1.18411472697187 0.857142857142857 5.3 5 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 2.33718300823832e-06 1.37430223996823e-05 1.18411472697187 0.857142857142857 5.3 5 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 2.33718300823832e-06 1.37430223996823e-05 1.18411472697187 0.857142857142857 5.3 5 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00102586719717226 0.00306039627164805 1.18411472697187 0.857142857142857 5.3 5 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00102586719717226 0.00306039627164805 1.18411472697187 0.857142857142857 5.3 5 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00102586719717226 0.00306039627164805 1.18411472697187 0.857142857142857 5.3 5 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0245503425863824 0.0492738187594107 1.18411472697187 0.857142857142857 5.3 5 3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0245503425863824 0.0492738187594107 1.18411472697187 0.857142857142857 5.3 5 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0245503425863824 0.0492738187594107 1.18411472697187 0.857142857142857 5.3 5 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0245503425863824 0.0492738187594107 1.18411472697187 0.857142857142857 5.3 5 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0245503425863824 0.0492738187594107 1.18411472697187 0.857142857142857 5.3 5 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0245503425863824 0.0492738187594107 1.18411472697187 0.857142857142857 5.3 5 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0245503425863824 0.0492738187594107 1.18411472697187 0.857142857142857 5.3 5 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 6.37207501394552e-10 6.55584748070946e-09 1.18000321750322 0.854166666666667 5.3 5 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 2.41004384339165e-07 1.66480213065355e-06 1.17831024301613 0.852941176470588 5.3 5 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 4.7988738148194e-06 2.56721708213835e-05 1.17680537680538 0.851851851851852 5.3 5 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 9.82512022569801e-05 0.000390534806736544 1.1742471042471 0.85 5.3 5 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 9.82512022569801e-05 0.000390534806736544 1.1742471042471 0.85 5.3 5 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 4.92200044904505e-07 3.22765282902816e-06 1.17215397215397 0.848484848484849 5.3 5 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 4.92200044904505e-07 3.22765282902816e-06 1.17215397215397 0.848484848484849 5.3 5 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 9.79654442456632e-06 4.89139744426592e-05 1.16893376893377 0.846153846153846 5.3 5 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00211407943680936 0.00589869615407789 1.16893376893377 0.846153846153846 5.3 5 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00211407943680936 0.00589869615407789 1.16893376893377 0.846153846153846 5.3 5 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00211407943680936 0.00589869615407789 1.16893376893377 0.846153846153846 5.3 5 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00211407943680936 0.00589869615407789 1.16893376893377 0.846153846153846 5.3 5 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.03726107037157e-07 7.56934616994228e-07 1.16334078439342 0.842105263157895 5.3 5 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000200447376938285 0.000740874330865402 1.16334078439342 0.842105263157895 5.3 5 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 1.98744269936869e-05 9.3646720569591e-05 1.16043243243243 0.84 5.3 5 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 1.98744269936869e-05 9.3646720569591e-05 1.16043243243243 0.84 5.3 5 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 1.98744269936869e-05 9.3646720569591e-05 1.16043243243243 0.84 5.3 5 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.32175079243712e-38 7.87808562939669e-36 1.15845005800163 0.838565022421525 5.3 5 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.31023527847702e-09 2.19164320084853e-08 1.15592151918683 0.836734693877551 5.3 5 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.80624891403637e-12 6.88498655978235e-11 1.15465913674869 0.835820895522388 5.3 5 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 4.62703425088036e-09 4.11516858687672e-08 1.15122265122265 0.833333333333333 5.3 5 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 4.00480170546303e-05 0.000172691903844663 1.15122265122265 0.833333333333333 5.3 5 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000405497422583566 0.00134052038982436 1.15122265122265 0.833333333333333 5.3 5 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000405497422583566 0.00134052038982436 1.15122265122265 0.833333333333333 5.3 5 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000405497422583566 0.00134052038982436 1.15122265122265 0.833333333333333 5.3 5 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000405497422583566 0.00134052038982436 1.15122265122265 0.833333333333333 5.3 5 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00430762199357181 0.0106419203070359 1.15122265122265 0.833333333333333 5.3 5 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00430762199357181 0.0106419203070359 1.15122265122265 0.833333333333333 5.3 5 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00430762199357181 0.0106419203070359 1.15122265122265 0.833333333333333 5.3 5 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00430762199357181 0.0106419203070359 1.15122265122265 0.833333333333333 5.3 5 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00430762199357181 0.0106419203070359 1.15122265122265 0.833333333333333 5.3 5 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00430762199357181 0.0106419203070359 1.15122265122265 0.833333333333333 5.3 5 3 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%REACT_196559.2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0509052849113033 0.0915780283549743 1.15122265122265 0.833333333333333 5.3 5 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.04490250459123e-10 1.70907616555554e-09 1.14732020155749 0.830508474576271 5.3 5 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.04490250459123e-10 1.70907616555554e-09 1.14732020155749 0.830508474576271 5.3 5 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 5.11000663748571e-13 1.32209808093494e-11 1.14201287001287 0.826666666666667 5.3 5 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 5.11000663748571e-13 1.32209808093494e-11 1.14201287001287 0.826666666666667 5.3 5 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 5.11000663748571e-13 1.32209808093494e-11 1.14201287001287 0.826666666666667 5.3 5 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 5.11000663748571e-13 1.32209808093494e-11 1.14201287001287 0.826666666666667 5.3 5 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 5.11000663748571e-13 1.32209808093494e-11 1.14201287001287 0.826666666666667 5.3 5 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 8.01087452439767e-05 0.000324771351801079 1.14121201947289 0.826086956521739 5.3 5 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 8.01087452439767e-05 0.000324771351801079 1.14121201947289 0.826086956521739 5.3 5 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 8.01087452439767e-05 0.000324771351801079 1.14121201947289 0.826086956521739 5.3 5 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 8.01087452439767e-05 0.000324771351801079 1.14121201947289 0.826086956521739 5.3 5 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00081261491536042 0.00249213582878853 1.13767885532591 0.823529411764706 5.3 5 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00081261491536042 0.00249213582878853 1.13767885532591 0.823529411764706 5.3 5 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 8.71081204573434e-11 1.47565304060476e-09 1.13636816540042 0.82258064516129 5.3 5 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 1.61226515250923e-05 7.72475862633213e-05 1.13477661334804 0.821428571428571 5.3 5 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.84724967575745e-11 3.5048483848038e-10 1.13404022359246 0.82089552238806 5.3 5 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.84724967575745e-11 3.5048483848038e-10 1.13404022359246 0.82089552238806 5.3 5 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 3.43833832494166e-07 2.31884143904833e-06 1.13351153351153 0.82051282051282 5.3 5 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 3.43833832494166e-07 2.31884143904833e-06 1.13351153351153 0.82051282051282 5.3 5 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 7.14613910915866e-08 5.29633122517332e-07 1.13029133029133 0.818181818181818 5.3 5 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3.28644700535557e-06 1.82680237836757e-05 1.13029133029133 0.818181818181818 5.3 5 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000158966386350733 0.00059843695179125 1.13029133029133 0.818181818181818 5.3 5 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00866204125840086 0.0196902311672595 1.13029133029133 0.818181818181818 5.3 5 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00866204125840086 0.0196902311672595 1.13029133029133 0.818181818181818 5.3 5 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00866204125840086 0.0196902311672595 1.13029133029133 0.818181818181818 5.3 5 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00866204125840086 0.0196902311672595 1.13029133029133 0.818181818181818 5.3 5 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00866204125840086 0.0196902311672595 1.13029133029133 0.818181818181818 5.3 5 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00866204125840086 0.0196902311672595 1.13029133029133 0.818181818181818 5.3 5 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00866204125840086 0.0196902311672595 1.13029133029133 0.818181818181818 5.3 5 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00866204125840086 0.0196902311672595 1.13029133029133 0.818181818181818 5.3 5 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.36546905810127e-10 4.16440214754618e-09 1.1281981981982 0.816666666666667 5.3 5 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.36546905810127e-10 4.16440214754618e-09 1.1281981981982 0.816666666666667 5.3 5 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.36546905810127e-10 4.16440214754618e-09 1.1281981981982 0.816666666666667 5.3 5 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.36546905810127e-10 4.16440214754618e-09 1.1281981981982 0.816666666666667 5.3 5 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.36546905810127e-10 4.16440214754618e-09 1.1281981981982 0.816666666666667 5.3 5 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.36546905810127e-10 4.16440214754618e-09 1.1281981981982 0.816666666666667 5.3 5 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.36546905810127e-10 4.16440214754618e-09 1.1281981981982 0.816666666666667 5.3 5 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 3.17862951074527e-05 0.000139604623265139 1.12563992563993 0.814814814814815 5.3 5 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.40083291239752e-07 9.91733947433664e-07 1.12445003142678 0.813953488372093 5.3 5 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.00161138595157619 0.00459519480780143 1.12244208494209 0.8125 5.3 5 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00161138595157619 0.00459519480780143 1.12244208494209 0.8125 5.3 5 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00161138595157619 0.00459519480780143 1.12244208494209 0.8125 5.3 5 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00161138595157619 0.00459519480780143 1.12244208494209 0.8125 5.3 5 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00161138595157619 0.00459519480780143 1.12244208494209 0.8125 5.3 5 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00161138595157619 0.00459519480780143 1.12244208494209 0.8125 5.3 5 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 6.1053179668169e-09 5.26537422229118e-08 1.12081299628469 0.811320754716981 5.3 5 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.31648649604014e-12 3.3452862211877e-11 1.11916328625189 0.810126582278481 5.3 5 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000312702206495462 0.00106453406661015 1.11833057547343 0.80952380952381 5.3 5 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000312702206495462 0.00106453406661015 1.11833057547343 0.80952380952381 5.3 5 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000312702206495462 0.00106453406661015 1.11833057547343 0.80952380952381 5.3 5 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.20501043688548e-11 2.48511572708411e-10 1.11652826995293 0.808219178082192 5.3 5 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 6.22015337839929e-05 0.000257304600507622 1.11580041580042 0.807692307692308 5.3 5 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 2.57138176436583e-06 1.46950853441469e-05 1.11284856284856 0.805555555555556 5.3 5 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 2.57138176436583e-06 1.46950853441469e-05 1.11284856284856 0.805555555555556 5.3 5 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 2.57138176436583e-06 1.46950853441469e-05 1.11284856284856 0.805555555555556 5.3 5 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.57138176436583e-06 1.46950853441469e-05 1.11284856284856 0.805555555555556 5.3 5 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.80828246728143e-09 4.24980493847297e-08 1.11010755653613 0.803571428571429 5.3 5 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 4.42211761841071e-08 3.41993117989046e-07 1.10517374517375 0.8 5.3 5 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000120742377298404 0.000460633787923937 1.10517374517375 0.8 5.3 5 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000120742377298404 0.000460633787923937 1.10517374517375 0.8 5.3 5 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.82860906384781e-11 3.5048483848038e-10 1.10517374517375 0.8 5.3 5 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000609232075663508 0.00191800275148047 1.10517374517375 0.8 5.3 5 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000609232075663508 0.00191800275148047 1.10517374517375 0.8 5.3 5 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000609232075663508 0.00191800275148047 1.10517374517375 0.8 5.3 5 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000609232075663508 0.00191800275148047 1.10517374517375 0.8 5.3 5 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000609232075663508 0.00191800275148047 1.10517374517375 0.8 5.3 5 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00315753516400529 0.00821420939374684 1.10517374517375 0.8 5.3 5 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00315753516400529 0.00821420939374684 1.10517374517375 0.8 5.3 5 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00315753516400529 0.00821420939374684 1.10517374517375 0.8 5.3 5 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00315753516400529 0.00821420939374684 1.10517374517375 0.8 5.3 5 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00315753516400529 0.00821420939374684 1.10517374517375 0.8 5.3 5 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00315753516400529 0.00821420939374684 1.10517374517375 0.8 5.3 5 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0171485251623983 0.035263513448111 1.10517374517375 0.8 5.3 5 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.3597954957051e-22 1.07499388354909e-20 1.10343605060586 0.79874213836478 5.3 5 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.51499864477943e-20 3.86285127980047e-18 1.10318602261048 0.798561151079137 5.3 5 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.16233318969062e-25 1.27230779148443e-23 1.1021541447771 0.797814207650273 5.3 5 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 7.42171514491304e-12 1.65017197675176e-10 1.10167635990421 0.79746835443038 5.3 5 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 7.42171514491304e-12 1.65017197675176e-10 1.10167635990421 0.79746835443038 5.3 5 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.65600034257076e-10 2.26585431488288e-09 1.10116949247384 0.797101449275362 5.3 5 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 7.84485221657232e-10 7.8064508420856e-09 1.10085666023166 0.796875 5.3 5 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.97072515108401e-22 3.72281152104871e-20 1.09989425276049 0.796178343949045 5.3 5 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 4.67946682567299e-05 0.000197008322276114 1.09564638530156 0.793103448275862 5.3 5 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.84361629112868e-19 1.04938639291044e-17 1.09530612244898 0.792857142857143 5.3 5 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000232339512363494 0.000814332822889783 1.09366151866152 0.791666666666667 5.3 5 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 7.76321658718768e-07 4.86654502359827e-06 1.09232288767173 0.790697674418605 5.3 5 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 5.46855267590103e-36 9.72718807225895e-34 1.09196854417443 0.790441176470588 5.3 5 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.08692055709224e-11 2.2745411069739e-10 1.09152962486296 0.790123456790123 5.3 5 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.08692055709224e-11 2.2745411069739e-10 1.09152962486296 0.790123456790123 5.3 5 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 4.23754581247245e-14 1.47073846125568e-12 1.09135907335907 0.79 5.3 5 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.23373797462321e-20 7.98004153585828e-19 1.09063198536883 0.789473684210526 5.3 5 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00117443509375337 0.00344581678022895 1.09063198536883 0.789473684210526 5.3 5 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00117443509375337 0.00344581678022895 1.09063198536883 0.789473684210526 5.3 5 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.05663589590757e-11 3.80076997386555e-10 1.08790540540541 0.7875 5.3 5 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.277621455538e-16 5.19444380351594e-15 1.08705614279385 0.786885245901639 5.3 5 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.47259453555823e-06 8.99357091888136e-06 1.08543849972421 0.785714285714286 5.3 5 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 8.92196549094409e-05 0.000359658835513129 1.08543849972421 0.785714285714286 5.3 5 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.00610419098214542 0.0143812314032996 1.08543849972421 0.785714285714286 5.3 5 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00610419098214542 0.0143812314032996 1.08543849972421 0.785714285714286 5.3 5 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00610419098214542 0.0143812314032996 1.08543849972421 0.785714285714286 5.3 5 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00610419098214542 0.0143812314032996 1.08543849972421 0.785714285714286 5.3 5 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00610419098214542 0.0143812314032996 1.08543849972421 0.785714285714286 5.3 5 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00610419098214542 0.0143812314032996 1.08543849972421 0.785714285714286 5.3 5 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.57740308446918e-19 4.69953261696539e-17 1.08543849972421 0.785714285714286 5.3 5 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.51227451850812e-13 4.75267565224958e-12 1.08543849972421 0.785714285714286 5.3 5 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.08214836201666e-17 9.55773264241839e-16 1.0839204039204 0.784615384615385 5.3 5 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.21546204223753e-07 8.71188208429852e-07 1.08350367173897 0.784313725490196 5.3 5 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.21546204223753e-07 8.71188208429852e-07 1.08350367173897 0.784313725490196 5.3 5 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 7.09903468477986e-06 3.63378645915171e-05 1.08277157466347 0.783783783783784 5.3 5 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.79800037715174e-07 3.75025206213042e-06 1.08114822897432 0.782608695652174 5.3 5 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000442853894335054 0.00144536947623574 1.08114822897432 0.782608695652174 5.3 5 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.000442853894335054 0.00144536947623574 1.08114822897432 0.782608695652174 5.3 5 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.77674412569108e-06 1.56797892494381e-05 1.07821828797439 0.780487804878049 5.3 5 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.77674412569108e-06 1.56797892494381e-05 1.07821828797439 0.780487804878049 5.3 5 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.37274260711298e-16 5.4261464720049e-15 1.07689173988387 0.779527559055118 5.3 5 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.40381447518352e-10 6.55584748070946e-09 1.07447447447447 0.777777777777778 5.3 5 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.33636095316156e-05 6.42446498766521e-05 1.07447447447447 0.777777777777778 5.3 5 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.33636095316156e-05 6.42446498766521e-05 1.07447447447447 0.777777777777778 5.3 5 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000168654869151883 0.000631568102113499 1.07447447447447 0.777777777777778 5.3 5 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0022375261400794 0.00614671756241889 1.07447447447447 0.777777777777778 5.3 5 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0022375261400794 0.00614671756241889 1.07447447447447 0.777777777777778 5.3 5 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0022375261400794 0.00614671756241889 1.07447447447447 0.777777777777778 5.3 5 3 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0022375261400794 0.00614671756241889 1.07447447447447 0.777777777777778 5.3 5 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0022375261400794 0.00614671756241889 1.07447447447447 0.777777777777778 5.3 5 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0333199321083272 0.0636433065639592 1.07447447447447 0.777777777777778 5.3 5 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0333199321083272 0.0636433065639592 1.07447447447447 0.777777777777778 5.3 5 3 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0333199321083272 0.0636433065639592 1.07447447447447 0.777777777777778 5.3 5 3 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0333199321083272 0.0636433065639592 1.07447447447447 0.777777777777778 5.3 5 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0333199321083272 0.0636433065639592 1.07447447447447 0.777777777777778 5.3 5 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0333199321083272 0.0636433065639592 1.07447447447447 0.777777777777778 5.3 5 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0333199321083272 0.0636433065639592 1.07447447447447 0.777777777777778 5.3 5 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0333199321083272 0.0636433065639592 1.07447447447447 0.777777777777778 5.3 5 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.1753454612843e-11 3.96861101462507e-10 1.07266863502158 0.776470588235294 5.3 5 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 4.27699708755233e-07 2.85735533126149e-06 1.07134189583169 0.775510204081633 5.3 5 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 6.47135599113866e-05 0.000266919987692473 1.0695229792004 0.774193548387097 5.3 5 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00083540399498754 0.00255102979585251 1.06749736749737 0.772727272727273 5.3 5 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00083540399498754 0.00255102979585251 1.06749736749737 0.772727272727273 5.3 5 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000315878522346438 0.00106885752493931 1.06266706266706 0.769230769230769 5.3 5 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.000315878522346438 0.00106885752493931 1.06266706266706 0.769230769230769 5.3 5 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0116194305161133 0.0254458641575548 1.06266706266706 0.769230769230769 5.3 5 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0116194305161133 0.0254458641575548 1.06266706266706 0.769230769230769 5.3 5 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0116194305161133 0.0254458641575548 1.06266706266706 0.769230769230769 5.3 5 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0116194305161133 0.0254458641575548 1.06266706266706 0.769230769230769 5.3 5 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0116194305161133 0.0254458641575548 1.06266706266706 0.769230769230769 5.3 5 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0116194305161133 0.0254458641575548 1.06266706266706 0.769230769230769 5.3 5 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.34687355750287e-19 1.28446195089484e-17 1.0620028957529 0.76875 5.3 5 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.50359464398832e-20 9.30267468867559e-19 1.06019574391667 0.767441860465116 5.3 5 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.000120547252791675 0.000460633787923937 1.05912483912484 0.766666666666667 5.3 5 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.47236438816209e-06 8.99357091888136e-06 1.05814507516635 0.765957446808511 5.3 5 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.58184904213276e-16 2.53134356404187e-14 1.05703170703171 0.765151515151515 5.3 5 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.01260395841196e-10 1.69521815625909e-09 1.05641607994549 0.764705882352941 5.3 5 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00420739181927742 0.0105037167698803 1.05641607994549 0.764705882352941 5.3 5 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.00420739181927742 0.0105037167698803 1.05641607994549 0.764705882352941 5.3 5 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00420739181927742 0.0105037167698803 1.05641607994549 0.764705882352941 5.3 5 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 6.35660741936743e-12 1.45894392867094e-10 1.05390279823269 0.762886597938144 5.3 5 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00155812765700126 0.00449739483957969 1.052546423975 0.761904761904762 5.3 5 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.26614611552225e-24 4.6835787014926e-22 1.052546423975 0.761904761904762 5.3 5 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.50491518199825e-08 2.72540672348826e-07 1.052546423975 0.761904761904762 5.3 5 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 2.70775887405863e-06 1.54125635111417e-05 1.05111633372503 0.760869565217391 5.3 5 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.05817712022361e-06 6.57548489990478e-06 1.04991505791506 0.76 5.3 5 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000222555327246532 0.000781966001658803 1.04800958594062 0.758620689655172 5.3 5 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.000222555327246532 0.000781966001658803 1.04800958594062 0.758620689655172 5.3 5 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000222555327246532 0.000781966001658803 1.04800958594062 0.758620689655172 5.3 5 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000222555327246532 0.000781966001658803 1.04800958594062 0.758620689655172 5.3 5 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 8.41007850847267e-12 1.81399761016179e-10 1.04656604656605 0.757575757575758 5.3 5 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 3.28533979439937e-05 0.000142967539065147 1.045434623813 0.756756756756757 5.3 5 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 3.28533979439937e-05 0.000142967539065147 1.045434623813 0.756756756756757 5.3 5 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.2724908034507e-05 6.15902861670187e-05 1.04452396647519 0.75609756097561 5.3 5 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.2724908034507e-05 6.15902861670187e-05 1.04452396647519 0.75609756097561 5.3 5 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 4.29393924632143e-27 5.09189628959617e-25 1.04303546231257 0.755020080321285 5.3 5 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 7.55535059861267e-07 4.75719641673709e-06 1.04261674072995 0.754716981132076 5.3 5 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 7.55535059861267e-07 4.75719641673709e-06 1.04261674072995 0.754716981132076 5.3 5 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 4.92773034917422e-28 6.37469116988629e-26 1.04141372141372 0.753846153846154 5.3 5 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 4.42416913933929e-10 5.33524803837272e-09 1.04016352486941 0.752941176470588 5.3 5 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 4.42416913933929e-10 5.33524803837272e-09 1.04016352486941 0.752941176470588 5.3 5 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 4.42416913933929e-10 5.33524803837272e-09 1.04016352486941 0.752941176470588 5.3 5 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 6.95800781636977e-11 1.20746891740173e-09 1.03981400755594 0.752688172043011 5.3 5 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.97842418740893e-11 3.7043389719512e-10 1.03610038610039 0.75 5.3 5 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 2.31326420729195e-05 0.000105168529296372 1.03610038610039 0.75 5.3 5 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00015549952672034 0.000588499538625117 1.03610038610039 0.75 5.3 5 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000406960511879215 0.00134052038982436 1.03610038610039 0.75 5.3 5 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00107439704024973 0.00319846650266813 1.03610038610039 0.75 5.3 5 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00287004414802294 0.0075630978196975 1.03610038610039 0.75 5.3 5 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00287004414802294 0.0075630978196975 1.03610038610039 0.75 5.3 5 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00287004414802294 0.0075630978196975 1.03610038610039 0.75 5.3 5 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00287004414802294 0.0075630978196975 1.03610038610039 0.75 5.3 5 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00287004414802294 0.0075630978196975 1.03610038610039 0.75 5.3 5 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00287004414802294 0.0075630978196975 1.03610038610039 0.75 5.3 5 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00779598280129256 0.0179792818550422 1.03610038610039 0.75 5.3 5 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00779598280129256 0.0179792818550422 1.03610038610039 0.75 5.3 5 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00779598280129256 0.0179792818550422 1.03610038610039 0.75 5.3 5 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.021725299052888 0.0443136554720395 1.03610038610039 0.75 5.3 5 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.021725299052888 0.0443136554720395 1.03610038610039 0.75 5.3 5 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0632781288137626 0.110756183643277 1.03610038610039 0.75 5.3 5 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.54955315803689e-15 1.29513183176577e-13 1.03361573289631 0.748201438848921 5.3 5 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.43561914025038e-09 1.40888692177675e-08 1.03193934037308 0.746987951807229 5.3 5 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.62592017798221e-09 3.30749000850557e-08 1.03172865451346 0.746835443037975 5.3 5 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.00290223554577e-12 9.49354980196939e-11 1.02982098982099 0.745454545454545 5.3 5 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 6.31099279125692e-06 3.24207319204281e-05 1.02875215641173 0.74468085106383 5.3 5 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.16303900949038e-14 2.31659193420564e-12 1.02806860016162 0.744186046511628 5.3 5 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.01896133859009e-09 1.0069319338984e-08 1.02806860016162 0.744186046511628 5.3 5 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.62001400068081e-05 7.7358386676805e-05 1.02806860016162 0.744186046511628 5.3 5 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 8.18496558929202e-17 3.42564883340075e-15 1.02746621621622 0.74375 5.3 5 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.84193901556791e-37 5.77725602736163e-35 1.02686597980716 0.74331550802139 5.3 5 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.90430411331596e-19 3.11178694564764e-17 1.02666413486086 0.743169398907104 5.3 5 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000108012707637833 0.000422258469694058 1.02623276337562 0.742857142857143 5.3 5 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.000281069119822503 0.000966090235525173 1.02495952173372 0.741935483870968 5.3 5 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.8180823197963e-09 1.74806158180415e-08 1.02391096979332 0.741176470588235 5.3 5 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.8180823197963e-09 1.74806158180415e-08 1.02391096979332 0.741176470588235 5.3 5 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000736517531473731 0.00226853776469073 1.02330902330902 0.740740740740741 5.3 5 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000736517531473731 0.00226853776469073 1.02330902330902 0.740740740740741 5.3 5 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000736517531473731 0.00226853776469073 1.02330902330902 0.740740740740741 5.3 5 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000736517531473731 0.00226853776469073 1.02330902330902 0.740740740740741 5.3 5 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000736517531473731 0.00226853776469073 1.02330902330902 0.740740740740741 5.3 5 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.12976088949469e-05 5.54361981293429e-05 1.02108443847574 0.739130434782609 5.3 5 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 2.89995845646991e-05 0.000129361783183595 1.01965434822578 0.738095238095238 5.3 5 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00521418106979231 0.0127487623063822 1.01792318634424 0.736842105263158 5.3 5 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.35518832845019e-21 9.64216495692311e-20 1.0172621972622 0.736363636363636 5.3 5 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000193337567364603 0.00071645666239539 1.01578469225528 0.735294117647059 5.3 5 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 5.71965956382671e-09 4.96285095080817e-08 1.01529515746383 0.734939759036145 5.3 5 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.8141412333257e-11 5.00565371877809e-10 1.01392086713188 0.73394495412844 5.3 5 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.00835762530086e-05 9.43198977162749e-05 1.01307593307593 0.733333333333333 5.3 5 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000503077531997389 0.00163442768957142 1.01307593307593 0.733333333333333 5.3 5 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0142074944820308 0.0300405121068794 1.01307593307593 0.733333333333333 5.3 5 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0142074944820308 0.0300405121068794 1.01307593307593 0.733333333333333 5.3 5 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 4.00697892049155e-09 3.6088170910503e-08 1.0120050282841 0.732558139534884 5.3 5 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.00827398063878e-08 8.64321611113843e-08 1.01082964497599 0.731707317073171 5.3 5 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.31818639163821e-07 1.60916060258594e-06 1.0103267446551 0.73134328358209 5.3 5 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 2.53869596471578e-08 2.08086735618102e-07 1.00953370953371 0.730769230769231 5.3 5 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 5.44370515122011e-06 2.80666392398051e-05 1.00953370953371 0.730769230769231 5.3 5 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 5.44370515122011e-06 2.80666392398051e-05 1.00953370953371 0.730769230769231 5.3 5 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00131818564531825 0.00383594718463777 1.00953370953371 0.730769230769231 5.3 5 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00131818564531825 0.00383594718463777 1.00953370953371 0.730769230769231 5.3 5 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00131818564531825 0.00383594718463777 1.00953370953371 0.730769230769231 5.3 5 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 2.80206889872328e-09 2.6232526597916e-08 1.00893670556592 0.730337078651685 5.3 5 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 5.86347675881795e-07 3.75843577828736e-06 1.00869032297604 0.73015873015873 5.3 5 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 6.4809644469066e-39 1.84448248158962e-36 1.0085359000852 0.730046948356808 5.3 5 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 6.97322526883039e-17 3.00693925986232e-15 1.00683201361167 0.728813559322034 5.3 5 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 3.54416178082116e-05 0.000153293076416672 1.0047034047034 0.727272727272727 5.3 5 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 3.54416178082116e-05 0.000153293076416672 1.0047034047034 0.727272727272727 5.3 5 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00348539075570449 0.00894510051257684 1.0047034047034 0.727272727272727 5.3 5 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0397791489063916 0.0745793529562519 1.0047034047034 0.727272727272727 5.3 5 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.1202977744078e-07 8.13359047439948e-07 1.0029830221611 0.726027397260274 5.3 5 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 9.56499665232375e-06 4.79260219586503e-05 1.00224089635854 0.725490196078431 5.3 5 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 9.07879715654712e-05 0.000364947128637473 1.00156370656371 0.725 5.3 5 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.05785062134537e-10 1.71059253883461e-09 1.00124685629273 0.724770642201835 5.3 5 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.67997515648331e-23 1.40623802804456e-21 1.00037278657968 0.724137931034483 5.3 5 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.77223971847879e-45 8.40632373131771e-43 0.998018115888838 0.722433460076046 5.3 5 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00932904258519223 0.0211388974502047 0.997726297726298 0.722222222222222 5.3 5 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00932904258519223 0.0211388974502047 0.997726297726298 0.722222222222222 5.3 5 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.7931379254324e-06 1.08120138469928e-05 0.99646813089436 0.721311475409836 5.3 5 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.7931379254324e-06 1.08120138469928e-05 0.99646813089436 0.721311475409836 5.3 5 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.48772280337517e-08 1.25268020662892e-07 0.995941456406573 0.720930232558139 5.3 5 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00233096829785576 0.00631803407209285 0.994656370656371 0.72 5.3 5 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00233096829785576 0.00631803407209285 0.994656370656371 0.72 5.3 5 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00233096829785576 0.00631803407209285 0.994656370656371 0.72 5.3 5 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00233096829785576 0.00631803407209285 0.994656370656371 0.72 5.3 5 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.18375059838817e-10 4.16440214754618e-09 0.99413993432685 0.719626168224299 5.3 5 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.71570473941329e-11 3.39089978359044e-10 0.991536928633703 0.717741935483871 5.3 5 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.71570473941329e-11 3.39089978359044e-10 0.991536928633703 0.717741935483871 5.3 5 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.71570473941329e-11 3.39089978359044e-10 0.991536928633703 0.717741935483871 5.3 5 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 2.57366587974603e-08 2.08086735618102e-07 0.991405859641154 0.717647058823529 5.3 5 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 2.57366587974603e-08 2.08086735618102e-07 0.991405859641154 0.717647058823529 5.3 5 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 2.57366587974603e-08 2.08086735618102e-07 0.991405859641154 0.717647058823529 5.3 5 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 2.57366587974603e-08 2.08086735618102e-07 0.991405859641154 0.717647058823529 5.3 5 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 2.57366587974603e-08 2.08086735618102e-07 0.991405859641154 0.717647058823529 5.3 5 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.23864164696267e-05 0.00018222317412773 0.991052543226456 0.717391304347826 5.3 5 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.97682712841599e-09 1.88793624411809e-08 0.990749190749191 0.717171717171717 5.3 5 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.40707285754626e-25 5.49590334020595e-23 0.990130061802417 0.716723549488055 5.3 5 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.10859199698433e-06 1.73471623988577e-05 0.99005148005148 0.716666666666667 5.3 5 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 6.43033715199013e-08 4.81598408804313e-07 0.989198722532056 0.716049382716049 5.3 5 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.95258391830243e-11 5.18707026635106e-10 0.98836676397652 0.715447154471545 5.3 5 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00010781183802832 0.000422258469694058 0.986762272476558 0.714285714285714 5.3 5 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00614983537557721 0.0144648194040436 0.986762272476558 0.714285714285714 5.3 5 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0254075293510329 0.050922414459887 0.986762272476558 0.714285714285714 5.3 5 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.116792640723605 0.18694705033711 0.986762272476558 0.714285714285714 5.3 5 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 5.84201682241462e-07 3.75843577828736e-06 0.986762272476558 0.714285714285714 5.3 5 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.000406649716681522 0.00134052038982436 0.986762272476558 0.714285714285714 5.3 5 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 6.37729953925776e-19 3.24103473012993e-17 0.984992295306197 0.713004484304933 5.3 5 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.52556756312414e-10 6.6327733159469e-09 0.984934934934935 0.712962962962963 5.3 5 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.97308490217127e-05 9.3646720569591e-05 0.982967032967033 0.711538461538462 5.3 5 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.75565673574344e-07 1.88524016103986e-06 0.981568786831945 0.710526315789474 5.3 5 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.63635716768314e-17 7.76178749871037e-16 0.980183857326714 0.70952380952381 5.3 5 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.74066181304976e-13 5.27013140419107e-12 0.979267875470407 0.708860759493671 5.3 5 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00406833614854634 0.0102103039495264 0.978539253539254 0.708333333333333 5.3 5 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00406833614854634 0.0102103039495264 0.978539253539254 0.708333333333333 5.3 5 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00406833614854634 0.0102103039495264 0.978539253539254 0.708333333333333 5.3 5 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00406833614854634 0.0102103039495264 0.978539253539254 0.708333333333333 5.3 5 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.50372547837076e-06 1.46617339741629e-05 0.977653697653698 0.707692307692308 5.3 5 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 9.1713070084822e-06 4.61157946044882e-05 0.976554386899214 0.706896551724138 5.3 5 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 9.1713070084822e-06 4.61157946044882e-05 0.976554386899214 0.706896551724138 5.3 5 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.46365479661084e-08 2.06222398563366e-07 0.976036595601813 0.706521739130435 5.3 5 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.77239452018218e-12 9.09850407155803e-11 0.975721575721576 0.706293706293706 5.3 5 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 3.94249658073181e-14 1.40254315859534e-12 0.975153304565069 0.705882352941177 5.3 5 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.71094420475127e-06 1.04045880485515e-05 0.975153304565069 0.705882352941177 5.3 5 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.000701680773914805 0.00218488346013297 0.975153304565069 0.705882352941177 5.3 5 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000701680773914805 0.00218488346013297 0.975153304565069 0.705882352941177 5.3 5 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.016408601158129 0.0342367147331635 0.975153304565069 0.705882352941177 5.3 5 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.016408601158129 0.0342367147331635 0.975153304565069 0.705882352941177 5.3 5 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.016408601158129 0.0342367147331635 0.975153304565069 0.705882352941177 5.3 5 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.016408601158129 0.0342367147331635 0.975153304565069 0.705882352941177 5.3 5 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 6.0970452370322e-08 4.5905266520089e-07 0.973306423306423 0.704545454545455 5.3 5 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.16892441749031e-06 7.23208454821178e-06 0.972864212300832 0.704225352112676 5.3 5 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 6.67291612193701e-14 2.20826968407357e-12 0.972749080441388 0.70414201183432 5.3 5 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00269964741569897 0.00720750144941771 0.972143572143572 0.703703703703704 5.3 5 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00269964741569897 0.00720750144941771 0.972143572143572 0.703703703703704 5.3 5 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00269964741569897 0.00720750144941771 0.972143572143572 0.703703703703704 5.3 5 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00269964741569897 0.00720750144941771 0.972143572143572 0.703703703703704 5.3 5 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.2033758647601e-07 1.53696267429099e-06 0.972143572143572 0.703703703703704 5.3 5 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 4.26027025106914e-06 2.30267058360613e-05 0.971344111969112 0.703125 5.3 5 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.52166857886716e-09 1.48310574501915e-08 0.970760722112073 0.702702702702703 5.3 5 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.9173070680766e-10 3.8797457550215e-09 0.970452152270334 0.702479338842975 5.3 5 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.9173070680766e-10 3.8797457550215e-09 0.970452152270334 0.702479338842975 5.3 5 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 5.45848829300502e-09 4.79470916107787e-08 0.969683694683695 0.701923076923077 5.3 5 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 7.05485591458854e-08 5.25605233846046e-07 0.967027027027027 0.7 5.3 5 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.97862289097028e-06 1.18301696380282e-05 0.967027027027027 0.7 5.3 5 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.06011447330982e-05 5.21987161079542e-05 0.967027027027027 0.7 5.3 5 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000316976722083197 0.00106885752493931 0.967027027027027 0.7 5.3 5 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.0106838338872542 0.0239796460907929 0.967027027027027 0.7 5.3 5 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0106838338872542 0.0239796460907929 0.967027027027027 0.7 5.3 5 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0106838338872542 0.0239796460907929 0.967027027027027 0.7 5.3 5 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0710532149821615 0.122556030205595 0.967027027027027 0.7 5.3 5 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.64102026918836e-13 1.32083436861101e-11 0.966179501148826 0.699386503067485 5.3 5 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 7.20509727707138e-06 3.66173336616878e-05 0.964834221977079 0.698412698412698 5.3 5 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 2.63568223930136e-05 0.000118314694843086 0.962093215664644 0.696428571428571 5.3 5 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 6.26376524554633e-07 3.97916872518412e-06 0.961780949122721 0.69620253164557 5.3 5 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00700027412835573 0.0163569623721678 0.96102064797717 0.695652173913043 5.3 5 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 5.52878900403722e-08 4.22982083480912e-07 0.959756147124568 0.694736842105263 5.3 5 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 5.52878900403722e-08 4.22982083480912e-07 0.959756147124568 0.694736842105263 5.3 5 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 9.69707901698717e-05 0.000387610770819459 0.958569064691514 0.693877551020408 5.3 5 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.2108778033871e-05 5.921234069484e-05 0.95811433553369 0.693548387096774 5.3 5 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 5.27774375293875e-12 1.2311851410544e-10 0.956400356400356 0.692307692307692 5.3 5 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 6.5453932505625e-05 0.000269193485420533 0.956400356400356 0.692307692307692 5.3 5 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000535989094393119 0.00171011767112423 0.956400356400356 0.692307692307692 5.3 5 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00460972926606514 0.0113097323200184 0.956400356400356 0.692307692307692 5.3 5 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00460972926606514 0.0113097323200184 0.956400356400356 0.692307692307692 5.3 5 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00460972926606514 0.0113097323200184 0.956400356400356 0.692307692307692 5.3 5 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0444635032606313 0.0827079282874226 0.956400356400356 0.692307692307692 5.3 5 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0444635032606313 0.0827079282874226 0.956400356400356 0.692307692307692 5.3 5 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0444635032606313 0.0827079282874226 0.956400356400356 0.692307692307692 5.3 5 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0444635032606313 0.0827079282874226 0.956400356400356 0.692307692307692 5.3 5 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0444635032606313 0.0827079282874226 0.956400356400356 0.692307692307692 5.3 5 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 4.42143401670527e-05 0.000186697347352273 0.954468234468235 0.690909090909091 5.3 5 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 4.42143401670527e-05 0.000186697347352273 0.954468234468235 0.690909090909091 5.3 5 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.42143401670527e-05 0.000186697347352273 0.954468234468235 0.690909090909091 5.3 5 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 4.42143401670527e-05 0.000186697347352273 0.954468234468235 0.690909090909091 5.3 5 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 4.42143401670527e-05 0.000186697347352273 0.954468234468235 0.690909090909091 5.3 5 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 4.42143401670527e-05 0.000186697347352273 0.954468234468235 0.690909090909091 5.3 5 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.98881118930365e-05 0.000132038163664884 0.952735987218746 0.689655172413793 5.3 5 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.56794709650568e-06 1.46950853441469e-05 0.952092246686841 0.689189189189189 5.3 5 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.56794709650568e-06 1.46950853441469e-05 0.952092246686841 0.689189189189189 5.3 5 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.61359803685595e-09 2.463013249302e-08 0.951935368742092 0.689075630252101 5.3 5 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 2.021710910526e-05 9.4634691634161e-05 0.951174124944617 0.688524590163934 5.3 5 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00202211501724243 0.00568669895165213 0.949758687258687 0.6875 5.3 5 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0283128201796548 0.0562697529548168 0.949758687258687 0.6875 5.3 5 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0283128201796548 0.0562697529548168 0.949758687258687 0.6875 5.3 5 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0283128201796548 0.0562697529548168 0.949758687258687 0.6875 5.3 5 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0283128201796548 0.0562697529548168 0.949758687258687 0.6875 5.3 5 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0283128201796548 0.0562697529548168 0.949758687258687 0.6875 5.3 5 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00016229751487982 0.000609365075656949 0.949758687258687 0.6875 5.3 5 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000109255572276629 0.000425947066711349 0.948065712771595 0.686274509803922 5.3 5 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.29918930127827e-08 2.59378252802154e-07 0.947291781577496 0.685714285714286 5.3 5 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.00134538489878742 0.00390710757341735 0.947291781577496 0.685714285714286 5.3 5 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.04458700348399e-08 8.90088207160306e-08 0.94521438731965 0.684210526315789 5.3 5 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.88689765751892e-06 1.61734463253915e-05 0.94521438731965 0.684210526315789 5.3 5 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000897320942470147 0.00272839252379278 0.94521438731965 0.684210526315789 5.3 5 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000897320942470147 0.00272839252379278 0.94521438731965 0.684210526315789 5.3 5 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000599743983191454 0.00190925209861619 0.943441001977587 0.682926829268293 5.3 5 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 6.13233567407872e-07 3.91314514090315e-06 0.941909441909442 0.681818181818182 5.3 5 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0118593595610188 0.0258040805127365 0.941909441909442 0.681818181818182 5.3 5 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0118593595610188 0.0258040805127365 0.941909441909442 0.681818181818182 5.3 5 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0118593595610188 0.0258040805127365 0.941909441909442 0.681818181818182 5.3 5 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.03616971671963e-05 5.11968578781957e-05 0.940999384477645 0.681159420289855 5.3 5 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.03616971671963e-05 5.11968578781957e-05 0.940999384477645 0.681159420289855 5.3 5 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.03616971671963e-05 5.11968578781957e-05 0.940999384477645 0.681159420289855 5.3 5 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00776024283126382 0.0179792818550422 0.939397683397683 0.68 5.3 5 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000121661919077199 0.00046290083114132 0.938355066656953 0.679245283018868 5.3 5 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.00502603456031e-06 6.27259669815494e-06 0.936857054098433 0.67816091954023 5.3 5 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00337221577477328 0.00867751003164987 0.935832606800349 0.67741935483871 5.3 5 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00337221577477328 0.00867751003164987 0.935832606800349 0.67741935483871 5.3 5 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00337221577477328 0.00867751003164987 0.935832606800349 0.67741935483871 5.3 5 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 4.11318853772471e-09 3.68117439571211e-08 0.935481713434469 0.677165354330709 5.3 5 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00223558126554278 0.00614671756241889 0.934521916874858 0.676470588235294 5.3 5 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00223558126554278 0.00614671756241889 0.934521916874858 0.676470588235294 5.3 5 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00223558126554278 0.00614671756241889 0.934521916874858 0.676470588235294 5.3 5 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00148645849170102 0.00429924884896454 0.933423771261609 0.675675675675676 5.3 5 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 6.69540656166675e-33 1.05861817080575e-30 0.931326189753156 0.674157303370786 5.3 5 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.94951174581857e-12 4.86693897245583e-11 0.930828154357566 0.67379679144385 5.3 5 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 5.12206229040073e-07 3.34343790790837e-06 0.930672627514733 0.673684210526316 5.3 5 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000297033884594086 0.00101850413922261 0.930375856906469 0.673469387755102 5.3 5 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 2.76866906041696e-05 0.000123893587200419 0.927851092030196 0.671641791044776 5.3 5 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 8.55491223115167e-06 4.33225626509923e-05 0.927037187563503 0.671052631578947 5.3 5 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.92235937388268e-06 2.15502601893245e-05 0.926593841227987 0.670731707317073 5.3 5 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 5.51352596235395e-09 4.81334199044765e-08 0.924440444741197 0.669172932330827 5.3 5 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.56337222533539e-51 1.11233933832613e-48 0.923582697112109 0.668552036199095 5.3 5 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.80862852122322e-08 2.23278122106181e-07 0.920978120978121 0.666666666666667 5.3 5 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.28817782611121e-06 2.30267058360613e-05 0.920978120978121 0.666666666666667 5.3 5 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.28817782611121e-06 2.30267058360613e-05 0.920978120978121 0.666666666666667 5.3 5 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 2.04412407359084e-05 9.53701166137627e-05 0.920978120978121 0.666666666666667 5.3 5 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000217734855765788 0.000780262477479986 0.920978120978121 0.666666666666667 5.3 5 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000217734855765788 0.000780262477479986 0.920978120978121 0.666666666666667 5.3 5 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000217734855765788 0.000780262477479986 0.920978120978121 0.666666666666667 5.3 5 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00108038311371867 0.00320288577254515 0.920978120978121 0.666666666666667 5.3 5 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00108038311371867 0.00320288577254515 0.920978120978121 0.666666666666667 5.3 5 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00161998463862422 0.00461047628152452 0.920978120978121 0.666666666666667 5.3 5 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00243500356925034 0.00658747163316204 0.920978120978121 0.666666666666667 5.3 5 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0036704596563737 0.00936032991222183 0.920978120978121 0.666666666666667 5.3 5 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0036704596563737 0.00936032991222183 0.920978120978121 0.666666666666667 5.3 5 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0036704596563737 0.00936032991222183 0.920978120978121 0.666666666666667 5.3 5 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0055513376399014 0.013298911551481 0.920978120978121 0.666666666666667 5.3 5 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0128641500879745 0.0276746727095705 0.920978120978121 0.666666666666667 5.3 5 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0128641500879745 0.0276746727095705 0.920978120978121 0.666666666666667 5.3 5 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0128641500879745 0.0276746727095705 0.920978120978121 0.666666666666667 5.3 5 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0197518309106081 0.0404997916221834 0.920978120978121 0.666666666666667 5.3 5 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0305677183040024 0.060341540883205 0.920978120978121 0.666666666666667 5.3 5 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0305677183040024 0.060341540883205 0.920978120978121 0.666666666666667 5.3 5 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0305677183040024 0.060341540883205 0.920978120978121 0.666666666666667 5.3 5 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0478075990890371 0.0880080381677876 0.920978120978121 0.666666666666667 5.3 5 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0478075990890371 0.0880080381677876 0.920978120978121 0.666666666666667 5.3 5 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0478075990890371 0.0880080381677876 0.920978120978121 0.666666666666667 5.3 5 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0478075990890371 0.0880080381677876 0.920978120978121 0.666666666666667 5.3 5 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0758868486133987 0.127343143368946 0.920978120978121 0.666666666666667 5.3 5 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0758868486133987 0.127343143368946 0.920978120978121 0.666666666666667 5.3 5 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0758868486133987 0.127343143368946 0.920978120978121 0.666666666666667 5.3 5 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0758868486133987 0.127343143368946 0.920978120978121 0.666666666666667 5.3 5 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0758868486133987 0.127343143368946 0.920978120978121 0.666666666666667 5.3 5 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0758868486133987 0.127343143368946 0.920978120978121 0.666666666666667 5.3 5 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.123194522224633 0.194655996013294 0.920978120978121 0.666666666666667 5.3 5 3 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.123194522224633 0.194655996013294 0.920978120978121 0.666666666666667 5.3 5 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.123194522224633 0.194655996013294 0.920978120978121 0.666666666666667 5.3 5 3 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.123194522224633 0.194655996013294 0.920978120978121 0.666666666666667 5.3 5 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.123194522224633 0.194655996013294 0.920978120978121 0.666666666666667 5.3 5 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.123194522224633 0.194655996013294 0.920978120978121 0.666666666666667 5.3 5 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.5783046671666e-10 6.63895570310502e-09 0.918007223813675 0.664516129032258 5.3 5 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 3.09276706728004e-07 2.10574523288971e-06 0.916674484898784 0.663551401869159 5.3 5 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.55184782247553e-07 3.01268811692218e-06 0.916550341550342 0.663461538461538 5.3 5 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.28183753647011e-11 4.11019596759109e-10 0.91597280510324 0.66304347826087 5.3 5 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.28326796979985e-05 0.000142967539065147 0.914492359562782 0.661971830985915 5.3 5 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.32202450789165e-08 2.5973850960054e-07 0.913726324749947 0.661417322834646 5.3 5 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000106822921681361 0.000421077610948965 0.913550878067007 0.661290322580645 5.3 5 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00015858092600319 0.00059843695179125 0.913173221647798 0.661016949152542 5.3 5 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 7.49891468001379e-43 2.66773889741491e-40 0.912723515540417 0.660691421254802 5.3 5 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00174515794152976 0.00491754406098385 0.909746680478388 0.658536585365854 5.3 5 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00174515794152976 0.00491754406098385 0.909746680478388 0.658536585365854 5.3 5 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00174515794152976 0.00491754406098385 0.909746680478388 0.658536585365854 5.3 5 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00174515794152976 0.00491754406098385 0.909746680478388 0.658536585365854 5.3 5 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00174515794152976 0.00491754406098385 0.909746680478388 0.658536585365854 5.3 5 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 2.39486236678411e-05 0.000108531501526554 0.908859987807356 0.657894736842105 5.3 5 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00394179096849056 0.00996299919744593 0.907821290678434 0.657142857142857 5.3 5 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00394179096849056 0.00996299919744593 0.907821290678434 0.657142857142857 5.3 5 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00394179096849056 0.00996299919744593 0.907821290678434 0.657142857142857 5.3 5 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00394179096849056 0.00996299919744593 0.907821290678434 0.657142857142857 5.3 5 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000114951391369467 0.000442096837618246 0.906587837837838 0.65625 5.3 5 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000253134123962069 0.00087217883389352 0.905099187857809 0.655172413793103 5.3 5 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 5.72183442146389e-07 3.71788601906079e-06 0.904233064233064 0.654545454545455 5.3 5 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 5.61285849467278e-05 0.000232859989443713 0.901791076791077 0.652777777777778 5.3 5 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.61285849467278e-05 0.000232859989443713 0.901791076791077 0.652777777777778 5.3 5 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 5.61285849467278e-05 0.000232859989443713 0.901791076791077 0.652777777777778 5.3 5 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 8.41348153694152e-12 1.81399761016179e-10 0.90124287552859 0.652380952380952 5.3 5 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00124513815192208 0.00364574401272658 0.900956857478597 0.652173913043478 5.3 5 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 8.30291378198654e-05 0.000335654724766104 0.900956857478597 0.652173913043478 5.3 5 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.86228241144396e-06 1.60989243932204e-05 0.897953667953668 0.65 5.3 5 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00278835721328655 0.00743039759270929 0.897953667953668 0.65 5.3 5 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00630107003956371 0.0147474057011499 0.893890529184647 0.647058823529412 5.3 5 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00630107003956371 0.0147474057011499 0.893890529184647 0.647058823529412 5.3 5 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00630107003956371 0.0147474057011499 0.893890529184647 0.647058823529412 5.3 5 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0501372217191189 0.0915780283549743 0.893890529184647 0.647058823529412 5.3 5 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0501372217191189 0.0915780283549743 0.893890529184647 0.647058823529412 5.3 5 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0501372217191189 0.0915780283549743 0.893890529184647 0.647058823529412 5.3 5 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0501372217191189 0.0915780283549743 0.893890529184647 0.647058823529412 5.3 5 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 3.97252223207307e-09 3.60057269824203e-08 0.892899519728788 0.646341463414634 5.3 5 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.00951337739467974 0.0215223148372484 0.891269149333665 0.645161290322581 5.3 5 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000424230386935279 0.00139417977045936 0.889758523656829 0.644067796610169 5.3 5 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 9.35832018385983e-05 0.000375123651313593 0.889437774369281 0.643835616438356 5.3 5 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.09583236534647e-05 9.71455848823461e-05 0.889220254737496 0.64367816091954 5.3 5 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.09583236534647e-05 9.71455848823461e-05 0.889220254737496 0.64367816091954 5.3 5 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0787642562979084 0.131705683562777 0.888086045228902 0.642857142857143 5.3 5 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000138180290714538 0.000524348143164766 0.888086045228902 0.642857142857143 5.3 5 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0013887064241124 0.00402470313953552 0.884138996138996 0.64 5.3 5 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000660956902808546 0.00206712455537706 0.88128078817734 0.637931034482759 5.3 5 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000660956902808546 0.00206712455537706 0.88128078817734 0.637931034482759 5.3 5 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000660956902808546 0.00206712455537706 0.88128078817734 0.637931034482759 5.3 5 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000979286328646041 0.00294614047708946 0.879115479115479 0.636363636363636 5.3 5 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.000979286328646041 0.00294614047708946 0.879115479115479 0.636363636363636 5.3 5 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000316567826229618 0.00106885752493931 0.879115479115479 0.636363636363636 5.3 5 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.00993831795900952 0.022412403257798 0.879115479115479 0.636363636363636 5.3 5 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00993831795900952 0.022412403257798 0.879115479115479 0.636363636363636 5.3 5 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.125782830614759 0.195568255202666 0.879115479115479 0.636363636363636 5.3 5 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00459656928433167 0.0113097323200184 0.876052358979188 0.634146341463415 5.3 5 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.95413586187208e-06 2.16412897363229e-05 0.875751516822945 0.633928571428571 5.3 5 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0516931053361914 0.0928778900169197 0.872505588295062 0.631578947368421 5.3 5 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.01984870039883e-06 1.20261284546759e-05 0.871909614532565 0.631147540983607 5.3 5 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.00320293676785809 0.00831711500120814 0.87092496222931 0.630434782608696 5.3 5 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0226894567833699 0.0460586262521188 0.86981266981267 0.62962962962963 5.3 5 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0226894567833699 0.0460586262521188 0.86981266981267 0.62962962962963 5.3 5 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00476472130851292 0.0116698768020893 0.86743288138637 0.627906976744186 5.3 5 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 4.56754092294218e-14 1.54752636508255e-12 0.864476395764739 0.625766871165644 5.3 5 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0154528716235923 0.0326252764397208 0.863416988416989 0.625 5.3 5 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0802988972713406 0.133800153181637 0.863416988416989 0.625 5.3 5 3 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.205983493906677 0.293104396923497 0.863416988416989 0.625 5.3 5 3 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 48%5605118 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS 0.205983493906677 0.293104396923497 0.863416988416989 0.625 5.3 5 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.205983493906677 0.293104396923497 0.863416988416989 0.625 5.3 5 3 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.205983493906677 0.293104396923497 0.863416988416989 0.625 5.3 5 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.205983493906677 0.293104396923497 0.863416988416989 0.625 5.3 5 3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.205983493906677 0.293104396923497 0.863416988416989 0.625 5.3 5 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.205983493906677 0.293104396923497 0.863416988416989 0.625 5.3 5 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0033116945710876 0.00858386407041468 0.863416988416988 0.625 5.3 5 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.95534206356394e-06 2.64099316721029e-05 0.857846556233653 0.620967741935484 5.3 5 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 7.19724932921582e-06 3.66173336616878e-05 0.856281310826765 0.619834710743802 5.3 5 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0526539035840886 0.0943658750631713 0.855193969479684 0.619047619047619 5.3 5 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 3.62458310077282e-06 1.99914021410842e-05 0.854189631288868 0.618320610687023 5.3 5 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 3.62458310077282e-06 1.99914021410842e-05 0.854189631288868 0.618320610687023 5.3 5 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.4032541961548e-07 2.92795828090107e-06 0.853517940142144 0.617834394904459 5.3 5 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 2.16361468862186e-24 2.05254913460593e-22 0.852943189801666 0.61741835147745 5.3 5 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00348877778248781 0.00894510051257684 0.85013365013365 0.615384615384615 5.3 5 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0351002431326847 0.0668643185780593 0.85013365013365 0.615384615384615 5.3 5 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.126164201177827 0.195568255202666 0.85013365013365 0.615384615384615 5.3 5 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.126164201177827 0.195568255202666 0.85013365013365 0.615384615384615 5.3 5 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 8.9238586930875e-56 1.26986509202635e-52 0.84814415079102 0.613944480309877 5.3 5 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 6.49938330830293e-21 4.40410592748337e-19 0.846783736450987 0.612959719789842 5.3 5 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.24547739369776e-10 1.99136441711451e-09 0.842844598079255 0.610108303249097 5.3 5 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.09681227031228e-06 2.23362600025072e-05 0.842597004299132 0.609929078014184 5.3 5 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00756521375710215 0.0176191475881446 0.840893066980024 0.608695652173913 5.3 5 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0531535618114767 0.094902783510328 0.840893066980024 0.608695652173913 5.3 5 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0354768934083293 0.0674914696792147 0.838747931605075 0.607142857142857 5.3 5 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 3.75045774837699e-17 1.66778167998139e-15 0.837252837252837 0.606060606060606 5.3 5 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.95771871296077e-07 1.37233188598186e-06 0.834636422136422 0.604166666666667 5.3 5 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.95771871296077e-07 1.37233188598186e-06 0.834636422136422 0.604166666666667 5.3 5 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00766171797506205 0.0177856846305274 0.834636422136422 0.604166666666667 5.3 5 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00766171797506205 0.0177856846305274 0.834636422136422 0.604166666666667 5.3 5 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.22308246301845e-09 2.958997641855e-08 0.833265918980205 0.603174603174603 5.3 5 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.22308246301845e-09 2.958997641855e-08 0.833265918980205 0.603174603174603 5.3 5 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.22308246301845e-09 2.958997641855e-08 0.833265918980205 0.603174603174603 5.3 5 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.67600243971697e-31 2.38495147171725e-29 0.829710018899208 0.600600600600601 5.3 5 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0532936951319957 0.0949148037206882 0.828880308880309 0.6 5.3 5 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0532936951319957 0.0949148037206882 0.828880308880309 0.6 5.3 5 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0164061070523805 0.0342367147331635 0.828880308880309 0.6 5.3 5 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0356533238476546 0.0676462397802833 0.828880308880309 0.6 5.3 5 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0356533238476546 0.0676462397802833 0.828880308880309 0.6 5.3 5 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0808038325897207 0.134484039503126 0.828880308880309 0.6 5.3 5 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.125199242111216 0.195568255202666 0.828880308880309 0.6 5.3 5 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.125199242111216 0.195568255202666 0.828880308880309 0.6 5.3 5 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.125199242111216 0.195568255202666 0.828880308880309 0.6 5.3 5 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.201406483088342 0.29160902848096 0.828880308880309 0.6 5.3 5 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.201406483088342 0.29160902848096 0.828880308880309 0.6 5.3 5 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.201406483088342 0.29160902848096 0.828880308880309 0.6 5.3 5 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.201406483088342 0.29160902848096 0.828880308880309 0.6 5.3 5 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.201406483088342 0.29160902848096 0.828880308880309 0.6 5.3 5 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000437127605672106 0.00143325479924287 0.823001725129385 0.595744680851064 5.3 5 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0037502245989979 0.00954663614378178 0.820246138996139 0.59375 5.3 5 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00780828966016589 0.0179792818550422 0.818647218647219 0.592592592592593 5.3 5 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.053152296004415 0.094902783510328 0.818647218647219 0.592592592592593 5.3 5 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.053152296004415 0.094902783510328 0.818647218647219 0.592592592592593 5.3 5 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000219877198502793 0.000780262477479986 0.816321516321516 0.590909090909091 5.3 5 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0802287059787649 0.133800153181637 0.816321516321516 0.590909090909091 5.3 5 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0802287059787649 0.133800153181637 0.816321516321516 0.590909090909091 5.3 5 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.91995162471509e-13 8.47977788157057e-12 0.814631992658898 0.589686098654709 5.3 5 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.123387005203086 0.194655996013294 0.812627753804224 0.588235294117647 5.3 5 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.123387005203086 0.194655996013294 0.812627753804224 0.588235294117647 5.3 5 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.53635333804273e-13 4.75267565224958e-12 0.805855855855856 0.583333333333333 5.3 5 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.195637205416663 0.28908799928132 0.805855855855856 0.583333333333333 5.3 5 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.195637205416663 0.28908799928132 0.805855855855856 0.583333333333333 5.3 5 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0522538754168873 0.0937670425198368 0.802142234400299 0.580645161290323 5.3 5 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0349783130649084 0.0667213666104083 0.799796789270473 0.578947368421053 5.3 5 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.121034064134204 0.192868391111951 0.799796789270473 0.578947368421053 5.3 5 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0781029478583292 0.130753523296944 0.797000297000297 0.576923076923077 5.3 5 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.56841619419026e-05 0.000310370496954834 0.793229542906962 0.574193548387097 5.3 5 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0109758683876959 0.0245576426347347 0.792645104120514 0.573770491803279 5.3 5 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0767194994658628 0.128588748810274 0.789409817981247 0.571428571428571 5.3 5 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.118337071263897 0.188782121534221 0.789409817981247 0.571428571428571 5.3 5 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.118337071263897 0.188782121534221 0.789409817981247 0.571428571428571 5.3 5 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.118337071263897 0.188782121534221 0.789409817981247 0.571428571428571 5.3 5 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.189364127684384 0.280692868432164 0.789409817981247 0.571428571428571 5.3 5 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.189364127684384 0.280692868432164 0.789409817981247 0.571428571428571 5.3 5 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.189364127684384 0.280692868432164 0.789409817981247 0.571428571428571 5.3 5 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.189364127684384 0.280692868432164 0.789409817981247 0.571428571428571 5.3 5 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.189364127684384 0.280692868432164 0.789409817981247 0.571428571428571 5.3 5 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.189364127684384 0.280692868432164 0.789409817981247 0.571428571428571 5.3 5 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0108584950342793 0.0243332888720936 0.789409817981247 0.571428571428571 5.3 5 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0231331591585074 0.0468924294623305 0.789409817981247 0.571428571428571 5.3 5 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0751992259342142 0.127088478033714 0.782831402831403 0.566666666666667 5.3 5 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0330481743774437 0.0636433065639592 0.780829276481451 0.565217391304348 5.3 5 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.11542639339624 0.186862068035096 0.780829276481451 0.565217391304348 5.3 5 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.182928256905341 0.272858395782285 0.77707528957529 0.5625 5.3 5 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.182928256905341 0.272858395782285 0.77707528957529 0.5625 5.3 5 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.182928256905341 0.272858395782285 0.77707528957529 0.5625 5.3 5 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.182928256905341 0.272858395782285 0.77707528957529 0.5625 5.3 5 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.182928256905341 0.272858395782285 0.77707528957529 0.5625 5.3 5 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.182928256905341 0.272858395782285 0.77707528957529 0.5625 5.3 5 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0324644988999753 0.062767638498186 0.77707528957529 0.5625 5.3 5 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0324644988999753 0.062767638498186 0.77707528957529 0.5625 5.3 5 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0217364241176975 0.0443136554720395 0.775560522928944 0.56140350877193 5.3 5 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.112390656566187 0.18215478848939 0.773621621621622 0.56 5.3 5 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.112390656566187 0.18215478848939 0.773621621621622 0.56 5.3 5 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.112390656566187 0.18215478848939 0.773621621621622 0.56 5.3 5 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.112390656566187 0.18215478848939 0.773621621621622 0.56 5.3 5 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0209438461677483 0.0428821483405839 0.769998101145642 0.557377049180328 5.3 5 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0460143032055334 0.0853694308493795 0.767481767481767 0.555555555555556 5.3 5 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0460143032055334 0.0853694308493795 0.767481767481767 0.555555555555556 5.3 5 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.30946970850923 0.428797853172965 0.767481767481767 0.555555555555556 5.3 5 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.30946970850923 0.428797853172965 0.767481767481767 0.555555555555556 5.3 5 3 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.30946970850923 0.428797853172965 0.767481767481767 0.555555555555556 5.3 5 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.30946970850923 0.428797853172965 0.767481767481767 0.555555555555556 5.3 5 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00010637094937865 0.000420460724905054 0.764365090253415 0.553299492385787 5.3 5 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0666721105653293 0.116553333334722 0.75980694980695 0.55 5.3 5 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.170204347133016 0.261555924373955 0.75980694980695 0.55 5.3 5 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.170204347133016 0.261555924373955 0.75980694980695 0.55 5.3 5 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0407594448510004 0.0763166973986495 0.753527553527554 0.545454545454545 5.3 5 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0999833035924567 0.165053643865506 0.753527553527554 0.545454545454545 5.3 5 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.164067109606056 0.252670451265603 0.753527553527554 0.545454545454545 5.3 5 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.164067109606056 0.252670451265603 0.753527553527554 0.545454545454545 5.3 5 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.292154866056642 0.406787059098436 0.753527553527554 0.545454545454545 5.3 5 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.292154866056642 0.406787059098436 0.753527553527554 0.545454545454545 5.3 5 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.292154866056642 0.406787059098436 0.753527553527554 0.545454545454545 5.3 5 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.292154866056642 0.406787059098436 0.753527553527554 0.545454545454545 5.3 5 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.292154866056642 0.406787059098436 0.753527553527554 0.545454545454545 5.3 5 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.292154866056642 0.406787059098436 0.753527553527554 0.545454545454545 5.3 5 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.292154866056642 0.406787059098436 0.753527553527554 0.545454545454545 5.3 5 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0969523855225489 0.160422377440218 0.749939327082184 0.542857142857143 5.3 5 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.158125525944567 0.244048398502297 0.748294723294723 0.541666666666667 5.3 5 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0159880232833443 0.033605549678285 0.747617533499886 0.541176470588235 5.3 5 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0159880232833443 0.033605549678285 0.747617533499886 0.541176470588235 5.3 5 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.276689043695305 0.388292415363332 0.743866943866944 0.538461538461538 5.3 5 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 9.96354399662583e-05 0.000394933791286868 0.742200015141192 0.537254901960784 5.3 5 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0882361165565664 0.146340319184142 0.74127507298239 0.536585365853659 5.3 5 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.146874066379404 0.227175865715101 0.740071704357419 0.535714285714286 5.3 5 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00100858267743665 0.00302787584386573 0.739271626839194 0.535135135135135 5.3 5 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0854738337020435 0.14192446366162 0.738924306366167 0.534883720930233 5.3 5 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0120426499013727 0.0261628867322953 0.735921769566629 0.532710280373832 5.3 5 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.136470935732685 0.211314626275963 0.73390444015444 0.53125 5.3 5 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0285509798401646 0.0566639390691133 0.7333714667048 0.530864197530864 5.3 5 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0319598168059466 0.0619602442981771 0.721432861432861 0.522222222222222 5.3 5 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00589193694747985 0.0140204452780331 0.721143245671548 0.522012578616352 5.3 5 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00589193694747985 0.0140204452780331 0.721143245671548 0.522012578616352 5.3 5 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0057289825694245 0.0136784265038441 0.720765485982877 0.521739130434783 5.3 5 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0562980692599655 0.100140190696164 0.720765485982877 0.521739130434783 5.3 5 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00557041296896804 0.0133221809325068 0.720396996470616 0.521472392638037 5.3 5 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0988475743225552 0.163368290663178 0.718362934362934 0.52 5.3 5 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0258506735697606 0.051737705330196 0.717300267300267 0.519230769230769 5.3 5 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00705416116007419 0.0164558546406321 0.716316316316316 0.518518518518518 5.3 5 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0464855651046765 0.0861314572186909 0.716316316316316 0.518518518518518 5.3 5 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.190484133504531 0.28205923202596 0.714551990414059 0.517241379310345 5.3 5 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.14933666024785 0.230734058124528 0.70758075148319 0.51219512195122 5.3 5 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00311338990101381 0.00818919376921008 0.705556199976801 0.510729613733906 5.3 5 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0157269892055718 0.033154823169672 0.699157171108391 0.50609756097561 5.3 5 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00333542941963169 0.00862966557115616 0.698859868271633 0.505882352941176 5.3 5 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0219468706688843 0.0446786794875856 0.695189936480259 0.503225806451613 5.3 5 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.170409687511406 0.261588980937142 0.690733590733591 0.5 5.3 5 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.342462594059239 0.468130904271178 0.690733590733591 0.5 5.3 5 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.239400231513977 0.336627005379831 0.690733590733591 0.5 5.3 5 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.323315191576688 0.447111290197888 0.690733590733591 0.5 5.3 5 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.323315191576688 0.447111290197888 0.690733590733591 0.5 5.3 5 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.364013959706227 0.486377337710761 0.690733590733591 0.5 5.3 5 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.364013959706227 0.486377337710761 0.690733590733591 0.5 5.3 5 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.364013959706227 0.486377337710761 0.690733590733591 0.5 5.3 5 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.364013959706227 0.486377337710761 0.690733590733591 0.5 5.3 5 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.38867252669662 0.508814172483247 0.690733590733591 0.5 5.3 5 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.38867252669662 0.508814172483247 0.690733590733591 0.5 5.3 5 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.38867252669662 0.508814172483247 0.690733590733591 0.5 5.3 5 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.262950285483601 0.369376363517437 0.690733590733591 0.5 5.3 5 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.306091873172587 0.425775890053364 0.690733590733591 0.5 5.3 5 3 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.417532933930119 0.535902066502649 0.690733590733591 0.5 5.3 5 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0468802085714045 0.0867497227530671 0.681004948610582 0.492957746478873 5.3 5 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0484113161665713 0.0890042673191615 0.680865968008825 0.492857142857143 5.3 5 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0938048964215489 0.155395072884591 0.676918918918919 0.49 5.3 5 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0604221541199601 0.10734172947903 0.675608037651833 0.489051094890511 5.3 5 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0725722321567987 0.125024559756809 0.670417896888485 0.485294117647059 5.3 5 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.279234662350924 0.391478743374744 0.66980226980227 0.484848484848485 5.3 5 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.121810432982554 0.193888418494602 0.668920951026214 0.484210526315789 5.3 5 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.126117413460431 0.195568255202666 0.668451862000249 0.483870967741935 5.3 5 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0838666708952682 0.139418542855101 0.665524335597328 0.481751824817518 5.3 5 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.357659483831044 0.479688450039186 0.660701695484304 0.478260869565217 5.3 5 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.224977541637334 0.316659784124556 0.651263099834528 0.471428571428571 5.3 5 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.424729642049338 0.541083509969747 0.65010220304338 0.470588235294118 5.3 5 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.424729642049338 0.541083509969747 0.65010220304338 0.470588235294118 5.3 5 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.348904351421998 0.473487211344369 0.647562741312741 0.46875 5.3 5 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.366133176044106 0.488291948932298 0.644684684684685 0.466666666666667 5.3 5 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.366133176044106 0.488291948932298 0.644684684684685 0.466666666666667 5.3 5 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.452667677152171 0.571558211701454 0.644684684684685 0.466666666666667 5.3 5 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.452667677152171 0.571558211701454 0.644684684684685 0.466666666666667 5.3 5 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.452667677152171 0.571558211701454 0.644684684684685 0.466666666666667 5.3 5 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.220822793548487 0.311119638831186 0.643638118638119 0.465909090909091 5.3 5 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.355088766208483 0.476689919164784 0.637600237600238 0.461538461538462 5.3 5 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.484658369269176 0.610326424309767 0.637600237600238 0.461538461538462 5.3 5 3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.484658369269176 0.610326424309767 0.637600237600238 0.461538461538462 5.3 5 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.426642676689729 0.543034462369843 0.633172458172458 0.458333333333333 5.3 5 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.34830185376749 0.473487211344369 0.627939627939628 0.454545454545455 5.3 5 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.406962425647893 0.532267951927345 0.627939627939628 0.454545454545455 5.3 5 3 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.522014657158018 0.649892263460944 0.627939627939628 0.454545454545455 5.3 5 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.522014657158018 0.649892263460944 0.627939627939628 0.454545454545455 5.3 5 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.476771312600945 0.601458845594986 0.621660231660232 0.45 5.3 5 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0124271161585776 0.0269569913013049 0.613236651285432 0.44390243902439 5.3 5 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.575141676441389 0.701308145309422 0.592057363485935 0.428571428571429 5.3 5 3 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.575141676441389 0.701308145309422 0.592057363485935 0.428571428571429 5.3 5 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.503603327160356 0.628069706002792 0.586076986076986 0.424242424242424 5.3 5 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.561573900083175 0.689490646952855 0.584466884466884 0.423076923076923 5.3 5 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.582876211568749 0.708311570505833 0.581670392196708 0.421052631578947 5.3 5 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.582876211568749 0.708311570505833 0.581670392196708 0.421052631578947 5.3 5 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.582876211568749 0.708311570505833 0.581670392196708 0.421052631578947 5.3 5 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.558605276638681 0.686799560492801 0.577068569473633 0.417721518987342 5.3 5 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.617259036059016 0.748364675910356 0.575611325611326 0.416666666666667 5.3 5 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.617259036059016 0.748364675910356 0.575611325611326 0.416666666666667 5.3 5 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.580377252451938 0.70708632725951 0.573439207401471 0.415094339622642 5.3 5 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.617939911591475 0.748364675910356 0.568839427662957 0.411764705882353 5.3 5 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.617939911591475 0.748364675910356 0.568839427662957 0.411764705882353 5.3 5 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.65419374290073 0.786802615827821 0.552586872586873 0.4 5.3 5 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.808096841399147 0.905450240402351 0.55187477610158 0.399484536082474 5.3 5 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.706643269649806 0.82520031754756 0.543528071396924 0.39344262295082 5.3 5 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.865237397667468 0.958084944532325 0.537785438499724 0.389285714285714 5.3 5 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.706900342298296 0.82520031754756 0.534761489600199 0.387096774193548 5.3 5 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.706900342298296 0.82520031754756 0.534761489600199 0.387096774193548 5.3 5 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.700134452802667 0.819318524949173 0.531333531333531 0.384615384615385 5.3 5 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.700134452802667 0.819318524949173 0.531333531333531 0.384615384615385 5.3 5 3 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.700134452802667 0.819318524949173 0.531333531333531 0.384615384615385 5.3 5 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.908356347830801 0.982212069120996 0.522029073181147 0.377880184331797 5.3 5 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.727835969813384 0.844099906311691 0.518050193050193 0.375 5.3 5 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.901473923565088 0.981327836413653 0.518050193050193 0.375 5.3 5 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.812975062419701 0.91019946012843 0.507477740130801 0.36734693877551 5.3 5 3 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.769574884114487 0.88816306577041 0.493381136238279 0.357142857142857 5.3 5 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.769574884114487 0.88816306577041 0.493381136238279 0.357142857142857 5.3 5 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.769574884114487 0.88816306577041 0.493381136238279 0.357142857142857 5.3 5 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.844305630168483 0.941572814835229 0.485380361056037 0.351351351351351 5.3 5 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.937106432408977 1 0.466974821904399 0.338028169014085 5.3 5 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.825966821521297 0.921843754529259 0.460489060489061 0.333333333333333 5.3 5 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.825966821521297 0.921843754529259 0.460489060489061 0.333333333333333 5.3 5 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.847530756232481 0.944429339169005 0.460489060489061 0.333333333333333 5.3 5 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.866518147303655 0.958084944532325 0.460489060489061 0.333333333333333 5.3 5 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.914909448290918 0.986300109786346 0.460489060489061 0.333333333333333 5.3 5 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.907013468061742 0.982212069120996 0.446945264592323 0.323529411764706 5.3 5 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.895435425250155 0.981327836413653 0.444043022614451 0.321428571428571 5.3 5 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.987522710196043 1 0.41968623234446 0.30379746835443 5.3 5 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.99969454194944 1 0.415925603022377 0.301075268817204 5.3 5 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.907740878645653 0.982212069120996 0.414440154440154 0.3 5.3 5 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.969456517638711 1 0.411500862564692 0.297872340425532 5.3 5 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.366535373084491 0.265323257766583 5.3 5 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.980278715833963 1 0.356507659733466 0.258064516129032 5.3 5 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.980278715833963 1 0.356507659733466 0.258064516129032 5.3 5 3 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.993830500664739 1 0.352715025055451 0.25531914893617 5.3 5 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.995427185886257 1 0.345366795366795 0.25 5.3 5 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.989601855887417 1 0.334901134901135 0.242424242424242 5.3 5 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.981590152668069 1 0.331552123552124 0.24 5.3 5 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.994334453952852 1 0.327189595610648 0.236842105263158 5.3 5 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.318511872761421 0.230560578661844 5.3 5 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999998329083177 1 0.294201344201344 0.212962962962963 5.3 5 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.998344131134275 1 0.276293436293436 0.2 5.3 5 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.996986946589235 1 0.276293436293436 0.2 5.3 5 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999139133208 1 0.260943800943801 0.188888888888889 5.3 5 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.998315024283209 1 0.24669056811914 0.178571428571429 5.3 5 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0490198032133516 0.0354838709677419 5.3 5 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 1.61515728644052e-05 8.97800319767521e-05 1.50731707317073 1 5.1 5 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 1.61515728644052e-05 8.97800319767521e-05 1.50731707317073 1 5.1 5 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 1.61515728644052e-05 8.97800319767521e-05 1.50731707317073 1 5.1 5 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000101633945856457 0.000451953452980431 1.50731707317073 1 5.1 5 1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.000101633945856457 0.000451953452980431 1.50731707317073 1 5.1 5 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000101633945856457 0.000451953452980431 1.50731707317073 1 5.1 5 1 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00402211929736248 0.0105794376342825 1.50731707317073 1 5.1 5 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00402211929736248 0.0105794376342825 1.50731707317073 1 5.1 5 1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.00402211929736248 0.0105794376342825 1.50731707317073 1 5.1 5 1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0100869696448974 0.0241239626969564 1.50731707317073 1 5.1 5 1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0100869696448974 0.0241239626969564 1.50731707317073 1 5.1 5 1 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605564 MUSCARINIC ACETYLCHOLINE RECEPTORS 0.0100869696448974 0.0241239626969564 1.50731707317073 1 5.1 5 1 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0100869696448974 0.0241239626969564 1.50731707317073 1 5.1 5 1 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.0100869696448974 0.0241239626969564 1.50731707317073 1 5.1 5 1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0100869696448974 0.0241239626969564 1.50731707317073 1 5.1 5 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0100869696448974 0.0241239626969564 1.50731707317073 1 5.1 5 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.000639418931808422 0.00223560968049972 1.50731707317073 1 5.1 5 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.000639418931808422 0.00223560968049972 1.50731707317073 1 5.1 5 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.000639418931808422 0.00223560968049972 1.50731707317073 1 5.1 5 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.000639418931808422 0.00223560968049972 1.50731707317073 1 5.1 5 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 1.62486310548751e-07 1.42727172784489e-06 1.50731707317073 1 5.1 5 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 2.56633635617881e-06 1.83466876574968e-05 1.50731707317073 1 5.1 5 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 2.56633635617881e-06 1.83466876574968e-05 1.50731707317073 1 5.1 5 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 2.56633635617881e-06 1.83466876574968e-05 1.50731707317073 1 5.1 5 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.000254930498759095 0.00100768361037276 1.50731707317073 1 5.1 5 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000254930498759095 0.00100768361037276 1.50731707317073 1 5.1 5 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000254930498759095 0.00100768361037276 1.50731707317073 1 5.1 5 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00160372490646648 0.00492894285507949 1.50731707317073 1 5.1 5 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00160372490646648 0.00492894285507949 1.50731707317073 1 5.1 5 1 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00160372490646648 0.00492894285507949 1.50731707317073 1 5.1 5 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 2.82631118256742e-10 3.90469981824606e-09 1.45348432055749 0.964285714285714 5.1 5 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 4.00170552099629e-09 4.55554156510218e-08 1.4470243902439 0.96 5.1 5 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 1.0251009712494e-05 6.02776314912356e-05 1.41310975609756 0.9375 5.1 5 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 1.0251009712494e-05 6.02776314912356e-05 1.41310975609756 0.9375 5.1 5 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 5.67743774208197e-05 0.000277468588069871 1.39965156794425 0.928571428571429 5.1 5 1 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.000308535782048527 0.00117392090335576 1.38170731707317 0.916666666666667 5.1 5 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000308535782048527 0.00117392090335576 1.38170731707317 0.916666666666667 5.1 5 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.000308535782048527 0.00117392090335576 1.38170731707317 0.916666666666667 5.1 5 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000308535782048527 0.00117392090335576 1.38170731707317 0.916666666666667 5.1 5 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000712804168123538 0.00246793267941556 1.37028824833703 0.909090909090909 5.1 5 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.000712804168123538 0.00246793267941556 1.37028824833703 0.909090909090909 5.1 5 1 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.000712804168123538 0.00246793267941556 1.37028824833703 0.909090909090909 5.1 5 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.000712804168123538 0.00246793267941556 1.37028824833703 0.909090909090909 5.1 5 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.09469673407407e-06 1.54443184071886e-05 1.36376306620209 0.904761904761905 5.1 5 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.00163459947488285 0.00499149152952423 1.35658536585366 0.9 5.1 5 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.00163459947488285 0.00499149152952423 1.35658536585366 0.9 5.1 5 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00163459947488285 0.00499149152952423 1.35658536585366 0.9 5.1 5 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.55669431159329e-08 1.66554586871974e-07 1.35658536585366 0.9 5.1 5 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 1.08173432095888e-05 6.30863909313315e-05 1.34865211810013 0.894736842105263 5.1 5 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 1.08173432095888e-05 6.30863909313315e-05 1.34865211810013 0.894736842105263 5.1 5 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 2.43880268560278e-05 0.0001304667752486 1.33983739837398 0.888888888888889 5.1 5 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00371532639620304 0.00986363705559127 1.33983739837398 0.888888888888889 5.1 5 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00371532639620304 0.00986363705559127 1.33983739837398 0.888888888888889 5.1 5 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00371532639620304 0.00986363705559127 1.33983739837398 0.888888888888889 5.1 5 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00371532639620304 0.00986363705559127 1.33983739837398 0.888888888888889 5.1 5 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00371532639620304 0.00986363705559127 1.33983739837398 0.888888888888889 5.1 5 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 5.46508689469499e-05 0.000268166160384516 1.3299856527977 0.882352941176471 5.1 5 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.97794073727891e-06 1.46594253601452e-05 1.31890243902439 0.875 5.1 5 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000121638286045871 0.000526113316240955 1.31890243902439 0.875 5.1 5 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000121638286045871 0.000526113316240955 1.31890243902439 0.875 5.1 5 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.000121638286045871 0.000526113316240955 1.31890243902439 0.875 5.1 5 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000121638286045871 0.000526113316240955 1.31890243902439 0.875 5.1 5 1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0083538667290729 0.0204253476898123 1.31890243902439 0.875 5.1 5 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.0083538667290729 0.0204253476898123 1.31890243902439 0.875 5.1 5 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 7.44125748863597e-08 6.92085582113005e-07 1.31282454760031 0.870967741935484 5.1 5 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000268674105504068 0.00104459904954177 1.30634146341463 0.866666666666667 5.1 5 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.000268674105504068 0.00104459904954177 1.30634146341463 0.866666666666667 5.1 5 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000268674105504068 0.00104459904954177 1.30634146341463 0.866666666666667 5.1 5 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.36439865898282e-08 1.4934917628712e-07 1.2979674796748 0.861111111111111 5.1 5 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.08352729485765e-05 0.000112305278052365 1.29198606271777 0.857142857142857 5.1 5 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000588326365829085 0.0020877516672688 1.29198606271777 0.857142857142857 5.1 5 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000588326365829085 0.0020877516672688 1.29198606271777 0.857142857142857 5.1 5 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000588326365829085 0.0020877516672688 1.29198606271777 0.857142857142857 5.1 5 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0185324856427385 0.0405095653911165 1.29198606271777 0.857142857142857 5.1 5 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0185324856427385 0.0405095653911165 1.29198606271777 0.857142857142857 5.1 5 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0185324856427385 0.0405095653911165 1.29198606271777 0.857142857142857 5.1 5 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0185324856427385 0.0405095653911165 1.29198606271777 0.857142857142857 5.1 5 1 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0185324856427385 0.0405095653911165 1.29198606271777 0.857142857142857 5.1 5 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 9.7677934673887e-11 1.59765173610277e-09 1.2875 0.854166666666667 5.1 5 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 2.48397252212215e-09 2.97033016720994e-08 1.28673408685306 0.853658536585366 5.1 5 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 2.48397252212215e-09 2.97033016720994e-08 1.28673408685306 0.853658536585366 5.1 5 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.10131757100408e-10 3.21524183176216e-09 1.28282304099637 0.851063829787234 5.1 5 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 4.50747305876701e-05 0.000226647850269451 1.28121951219512 0.85 5.1 5 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.3121110934095e-13 5.49157084094624e-12 1.27542213883677 0.846153846153846 5.1 5 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 3.59657565176526e-06 2.29546943944545e-05 1.27542213883677 0.846153846153846 5.1 5 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 3.59657565176526e-06 2.29546943944545e-05 1.27542213883677 0.846153846153846 5.1 5 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 3.59657565176526e-06 2.29546943944545e-05 1.27542213883677 0.846153846153846 5.1 5 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 3.59657565176526e-06 2.29546943944545e-05 1.27542213883677 0.846153846153846 5.1 5 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 3.59657565176526e-06 2.29546943944545e-05 1.27542213883677 0.846153846153846 5.1 5 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00127557551660871 0.00405166062529954 1.27542213883677 0.846153846153846 5.1 5 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00127557551660871 0.00405166062529954 1.27542213883677 0.846153846153846 5.1 5 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 9.62073232418956e-10 1.25599101810291e-08 1.27284552845528 0.844444444444444 5.1 5 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.93901763720452e-07 2.46013064573061e-06 1.2717987804878 0.84375 5.1 5 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 9.67650063037024e-05 0.000437132076095773 1.26931964056483 0.842105263157895 5.1 5 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 5.17769341303542e-08 4.94487095754994e-07 1.26288727752142 0.837837837837838 5.1 5 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 1.62823789947735e-05 9.01549622940185e-05 1.25609756097561 0.833333333333333 5.1 5 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0027341460984986 0.007510984359389 1.25609756097561 0.833333333333333 5.1 5 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605630 MULTIFUNCTIONAL ANION EXCHANGERS 0.0404112213825723 0.0779202818799464 1.25609756097561 0.833333333333333 5.1 5 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.09366158904892e-07 9.97615667446543e-07 1.25609756097561 0.833333333333333 5.1 5 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000205965079401559 0.000832637238603461 1.25609756097561 0.833333333333333 5.1 5 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000205965079401559 0.000832637238603461 1.25609756097561 0.833333333333333 5.1 5 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.000205965079401559 0.000832637238603461 1.25609756097561 0.833333333333333 5.1 5 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 2.78162042360644e-06 1.86227041249333e-05 1.24743481917578 0.827586206896552 5.1 5 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 3.42718873009877e-05 0.000176698897207629 1.24517497348887 0.826086956521739 5.1 5 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 4.40251842969047e-12 1.22838896577442e-10 1.24413472706156 0.825396825396825 5.1 5 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.0602756533532e-15 6.03508901888639e-14 1.24131994261119 0.823529411764706 5.1 5 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.000434246232507503 0.00160919892931817 1.24131994261119 0.823529411764706 5.1 5 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000434246232507503 0.00160919892931817 1.24131994261119 0.823529411764706 5.1 5 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 7.06391632999298e-09 7.9777404266508e-08 1.23934959349594 0.822222222222222 5.1 5 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.06642041757726e-10 1.72445028887777e-09 1.23815331010453 0.821428571428571 5.1 5 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 5.81117320451889e-06 3.61104780350672e-05 1.23815331010453 0.821428571428571 5.1 5 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 5.81117320451889e-06 3.61104780350672e-05 1.23815331010453 0.821428571428571 5.1 5 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 1.46434338362498e-08 1.57860654158965e-07 1.23325942350333 0.818181818181818 5.1 5 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.46434338362498e-08 1.57860654158965e-07 1.23325942350333 0.818181818181818 5.1 5 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 7.15572121030654e-05 0.000333385353938441 1.23325942350333 0.818181818181818 5.1 5 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.00578267835529973 0.0147468661283002 1.23325942350333 0.818181818181818 5.1 5 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00578267835529973 0.0147468661283002 1.23325942350333 0.818181818181818 5.1 5 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00578267835529973 0.0147468661283002 1.23325942350333 0.818181818181818 5.1 5 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00578267835529973 0.0147468661283002 1.23325942350333 0.818181818181818 5.1 5 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00578267835529973 0.0147468661283002 1.23325942350333 0.818181818181818 5.1 5 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00578267835529973 0.0147468661283002 1.23325942350333 0.818181818181818 5.1 5 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00578267835529973 0.0147468661283002 1.23325942350333 0.818181818181818 5.1 5 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 9.98125387173501e-07 7.67747257269131e-06 1.23325942350333 0.818181818181818 5.1 5 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 9.98125387173501e-07 7.67747257269131e-06 1.23325942350333 0.818181818181818 5.1 5 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 9.98125387173501e-07 7.67747257269131e-06 1.23325942350333 0.818181818181818 5.1 5 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 9.98125387173501e-07 7.67747257269131e-06 1.23325942350333 0.818181818181818 5.1 5 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 1.20557890523276e-05 6.94550114229236e-05 1.22818428184282 0.814814814814815 5.1 5 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 1.20557890523276e-05 6.94550114229236e-05 1.22818428184282 0.814814814814815 5.1 5 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 3.02124760943781e-08 2.94468174536302e-07 1.22688598979013 0.813953488372093 5.1 5 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.43364256724446e-11 2.97994897677021e-10 1.22469512195122 0.8125 5.1 5 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000905829323156253 0.00300465064534114 1.22469512195122 0.8125 5.1 5 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000905829323156253 0.00300465064534114 1.22469512195122 0.8125 5.1 5 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000905829323156253 0.00300465064534114 1.22469512195122 0.8125 5.1 5 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000905829323156253 0.00300465064534114 1.22469512195122 0.8125 5.1 5 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000905829323156253 0.00300465064534114 1.22469512195122 0.8125 5.1 5 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000905829323156253 0.00300465064534114 1.22469512195122 0.8125 5.1 5 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000905829323156253 0.00300465064534114 1.22469512195122 0.8125 5.1 5 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.000905829323156253 0.00300465064534114 1.22469512195122 0.8125 5.1 5 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 9.30567935131848e-13 2.87869167759265e-11 1.2182425659873 0.808219178082192 5.1 5 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 2.48231961160676e-05 0.000132297408513724 1.21744840525328 0.807692307692308 5.1 5 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.06445735375331e-11 2.56732680405248e-10 1.21485256643611 0.805970149253731 5.1 5 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.89552080846318e-12 5.39465222088621e-11 1.21422764227642 0.805555555555556 5.1 5 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.21585190675929e-08 2.23432531387033e-07 1.21240721102863 0.804347826086957 5.1 5 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 2.21585190675929e-08 2.23432531387033e-07 1.21240721102863 0.804347826086957 5.1 5 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 2.57298957373694e-07 2.16648767066726e-06 1.20585365853659 0.8 5.1 5 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 5.06974227788813e-05 0.000250494557688708 1.20585365853659 0.8 5.1 5 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 5.06974227788813e-05 0.000250494557688708 1.20585365853659 0.8 5.1 5 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.00030352610916783 0.00117050854565263 1.20585365853659 0.8 5.1 5 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.00030352610916783 0.00117050854565263 1.20585365853659 0.8 5.1 5 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0120382340814838 0.0276296888676636 1.20585365853659 0.8 5.1 5 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0120382340814838 0.0276296888676636 1.20585365853659 0.8 5.1 5 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0120382340814838 0.0276296888676636 1.20585365853659 0.8 5.1 5 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0120382340814838 0.0276296888676636 1.20585365853659 0.8 5.1 5 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0120382340814838 0.0276296888676636 1.20585365853659 0.8 5.1 5 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0120382340814838 0.0276296888676636 1.20585365853659 0.8 5.1 5 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0120382340814838 0.0276296888676636 1.20585365853659 0.8 5.1 5 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0120382340814838 0.0276296888676636 1.20585365853659 0.8 5.1 5 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.4661905182911e-10 3.44057755640023e-09 1.20585365853659 0.8 5.1 5 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.4661905182911e-10 3.44057755640023e-09 1.20585365853659 0.8 5.1 5 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.4661905182911e-10 3.44057755640023e-09 1.20585365853659 0.8 5.1 5 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.4661905182911e-10 3.44057755640023e-09 1.20585365853659 0.8 5.1 5 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.4661905182911e-10 3.44057755640023e-09 1.20585365853659 0.8 5.1 5 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.4661905182911e-10 3.44057755640023e-09 1.20585365853659 0.8 5.1 5 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.4661905182911e-10 3.44057755640023e-09 1.20585365853659 0.8 5.1 5 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 1.48239129516664e-06 1.12804428503857e-05 1.20585365853659 0.8 5.1 5 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00186693540712915 0.00561659425865705 1.20585365853659 0.8 5.1 5 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00186693540712915 0.00561659425865705 1.20585365853659 0.8 5.1 5 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.5705985471382e-11 2.97994897677021e-10 1.20148462354189 0.797101449275362 5.1 5 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 2.99530319145236e-06 1.99173665487697e-05 1.19698708751793 0.794117647058823 5.1 5 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.74244588646833e-05 9.61046704048228e-05 1.19545836837679 0.793103448275862 5.1 5 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000102632018864602 0.00045496997770819 1.19329268292683 0.791666666666667 5.1 5 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 1.82210724350383e-07 1.59071080215089e-06 1.19183210436756 0.790697674418605 5.1 5 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000615465353518521 0.0021786248707882 1.18998716302952 0.789473684210526 5.1 5 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.43354192892806e-12 4.24985451013466e-11 1.18701219512195 0.7875 5.1 5 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 6.39389073227286e-08 6.02550100134058e-07 1.18661131292164 0.787234042553192 5.1 5 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 8.00348360006332e-12 1.96361330394657e-10 1.18575609756098 0.786666666666667 5.1 5 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 8.00348360006332e-12 1.96361330394657e-10 1.18575609756098 0.786666666666667 5.1 5 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 8.00348360006332e-12 1.96361330394657e-10 1.18575609756098 0.786666666666667 5.1 5 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 8.00348360006332e-12 1.96361330394657e-10 1.18575609756098 0.786666666666667 5.1 5 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 8.00348360006332e-12 1.96361330394657e-10 1.18575609756098 0.786666666666667 5.1 5 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 3.63729900676826e-07 3.00923051548328e-06 1.18432055749129 0.785714285714286 5.1 5 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00379548906946733 0.0100389980406171 1.18432055749129 0.785714285714286 5.1 5 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00379548906946733 0.0100389980406171 1.18432055749129 0.785714285714286 5.1 5 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.24531637303905e-08 2.23432531387033e-07 1.18220946915351 0.784313725490196 5.1 5 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.24531637303905e-08 2.23432531387033e-07 1.18220946915351 0.784313725490196 5.1 5 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000205784381390546 0.000832637238603461 1.1796394485684 0.782608695652174 5.1 5 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 4.11971360751034e-06 2.58253412488423e-05 1.17235772357724 0.777777777777778 5.1 5 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 6.9509120839158e-05 0.000325366707085927 1.17235772357724 0.777777777777778 5.1 5 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.9509120839158e-05 0.000325366707085927 1.17235772357724 0.777777777777778 5.1 5 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 6.9509120839158e-05 0.000325366707085927 1.17235772357724 0.777777777777778 5.1 5 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 6.9509120839158e-05 0.000325366707085927 1.17235772357724 0.777777777777778 5.1 5 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.00123323026837831 0.00393472347960164 1.17235772357724 0.777777777777778 5.1 5 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00123323026837831 0.00393472347960164 1.17235772357724 0.777777777777778 5.1 5 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0245887578941175 0.0513046957233566 1.17235772357724 0.777777777777778 5.1 5 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.53484530776385e-18 1.21338048497108e-16 1.17106941838649 0.776923076923077 5.1 5 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 1.42308033436938e-06 1.08873296548797e-05 1.16817073170732 0.775 5.1 5 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000408312151286381 0.00152101620754063 1.16474501108647 0.772727272727273 5.1 5 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000408312151286381 0.00152101620754063 1.16474501108647 0.772727272727273 5.1 5 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 2.3681790948095e-10 3.44057755640023e-09 1.16278745644599 0.771428571428571 5.1 5 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 4.26591549471462e-14 1.95819282225126e-12 1.16063414634146 0.77 5.1 5 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 5.96763856131646e-08 5.66129978183555e-07 1.15947467166979 0.769230769230769 5.1 5 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00759604803813154 0.0187985675795847 1.15947467166979 0.769230769230769 5.1 5 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00759604803813154 0.0187985675795847 1.15947467166979 0.769230769230769 5.1 5 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00759604803813154 0.0187985675795847 1.15947467166979 0.769230769230769 5.1 5 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00759604803813154 0.0187985675795847 1.15947467166979 0.769230769230769 5.1 5 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00759604803813154 0.0187985675795847 1.15947467166979 0.769230769230769 5.1 5 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.60184024770805e-29 6.40677334061069e-27 1.15583506507711 0.766816143497758 5.1 5 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 4.63641607724384e-05 0.000231495441330456 1.15560975609756 0.766666666666667 5.1 5 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 1.58096523885267e-05 8.90545962994642e-05 1.15265423242468 0.764705882352941 5.1 5 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00243847436776469 0.00707793121610785 1.15265423242468 0.764705882352941 5.1 5 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00243847436776469 0.00707793121610785 1.15265423242468 0.764705882352941 5.1 5 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00243847436776469 0.00707793121610785 1.15265423242468 0.764705882352941 5.1 5 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00243847436776469 0.00707793121610785 1.15265423242468 0.764705882352941 5.1 5 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000800913896732671 0.00273309466438991 1.14843205574913 0.761904761904762 5.1 5 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000800913896732671 0.00273309466438991 1.14843205574913 0.761904761904762 5.1 5 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 2.2387900901823e-07 1.90766365169426e-06 1.14556097560976 0.76 5.1 5 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 2.2387900901823e-07 1.90766365169426e-06 1.14556097560976 0.76 5.1 5 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000267091573136052 0.00104459904954177 1.14556097560976 0.76 5.1 5 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000267091573136052 0.00104459904954177 1.14556097560976 0.76 5.1 5 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000267091573136052 0.00104459904954177 1.14556097560976 0.76 5.1 5 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 9.00415151397323e-05 0.000410298130831281 1.1434819175778 0.758620689655172 5.1 5 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 9.46855526081644e-09 1.05660555120375e-07 1.1426435877262 0.758064516129032 5.1 5 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 3.06017041145118e-05 0.000160687176955536 1.14190687361419 0.757575757575758 5.1 5 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.59725709765521e-06 2.29546943944545e-05 1.13967876264128 0.75609756097561 5.1 5 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.59725709765521e-06 2.29546943944545e-05 1.13967876264128 0.75609756097561 5.1 5 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.37562236980044e-14 1.60117021074201e-12 1.13733924611973 0.754545454545455 5.1 5 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.48592501899845e-15 8.13258193090304e-14 1.13666533386645 0.754098360655738 5.1 5 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.74012510523238e-25 2.47619802474568e-23 1.13407665505226 0.752380952380952 5.1 5 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.000515241468968373 0.00186561987364375 1.13048780487805 0.75 5.1 5 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.000515241468968373 0.00186561987364375 1.13048780487805 0.75 5.1 5 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000515241468968373 0.00186561987364375 1.13048780487805 0.75 5.1 5 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.000515241468968373 0.00186561987364375 1.13048780487805 0.75 5.1 5 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.000515241468968373 0.00186561987364375 1.13048780487805 0.75 5.1 5 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000515241468968373 0.00186561987364375 1.13048780487805 0.75 5.1 5 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0015512830865706 0.00483036287131282 1.13048780487805 0.75 5.1 5 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0015512830865706 0.00483036287131282 1.13048780487805 0.75 5.1 5 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0015512830865706 0.00483036287131282 1.13048780487805 0.75 5.1 5 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0015512830865706 0.00483036287131282 1.13048780487805 0.75 5.1 5 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0015512830865706 0.00483036287131282 1.13048780487805 0.75 5.1 5 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0149282751257031 0.0331920867248056 1.13048780487805 0.75 5.1 5 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0149282751257031 0.0331920867248056 1.13048780487805 0.75 5.1 5 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0149282751257031 0.0331920867248056 1.13048780487805 0.75 5.1 5 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 2.00463825431359e-05 0.000108463887296131 1.13048780487805 0.75 5.1 5 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000173178341873754 0.00071846291686983 1.13048780487805 0.75 5.1 5 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00475025365904787 0.0124257554353403 1.13048780487805 0.75 5.1 5 1 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0490683423837351 0.0923601206508665 1.13048780487805 0.75 5.1 5 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.43904775739886e-10 4.61675939507413e-09 1.12571781414017 0.746835443037975 5.1 5 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.43904775739886e-10 4.61675939507413e-09 1.12571781414017 0.746835443037975 5.1 5 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 3.43904775739886e-10 4.61675939507413e-09 1.12571781414017 0.746835443037975 5.1 5 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.68260568710001e-31 4.78869578548663e-29 1.12494619799139 0.746323529411765 5.1 5 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 6.57543285840596e-12 1.76544169009654e-10 1.1188332914257 0.742268041237113 5.1 5 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.50435847065658e-10 2.32685011276556e-09 1.11718794835007 0.741176470588235 5.1 5 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.50435847065658e-10 2.32685011276556e-09 1.11718794835007 0.741176470588235 5.1 5 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.50435847065658e-10 2.32685011276556e-09 1.11718794835007 0.741176470588235 5.1 5 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000982140832657913 0.00322768222834229 1.11410392364793 0.739130434782609 5.1 5 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000982140832657913 0.00322768222834229 1.11410392364793 0.739130434782609 5.1 5 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 8.90494050474661e-28 1.40797003758383e-25 1.11384072876873 0.738955823293173 5.1 5 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.81951996826701e-08 2.76701856196135e-07 1.113095684803 0.738461538461539 5.1 5 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.41532857529795e-19 1.25875785165562e-17 1.11296086216676 0.738372093023256 5.1 5 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0029629720299857 0.00807722068710661 1.11065468549422 0.736842105263158 5.1 5 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0029629720299857 0.00807722068710661 1.11065468549422 0.736842105263158 5.1 5 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0029629720299857 0.00807722068710661 1.11065468549422 0.736842105263158 5.1 5 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 5.91940342452665e-18 4.01110051100068e-16 1.10915784629544 0.735849056603774 5.1 5 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 6.61670551197379e-07 5.25096507052511e-06 1.10915784629544 0.735849056603774 5.1 5 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 7.16907366866922e-05 0.000333385353938441 1.10832137733142 0.735294117647059 5.1 5 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000210154239649789 0.000844772550908617 1.10536585365854 0.733333333333333 5.1 5 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0090990116408973 0.0220202271513552 1.10536585365854 0.733333333333333 5.1 5 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0090990116408973 0.0220202271513552 1.10536585365854 0.733333333333333 5.1 5 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0090990116408973 0.0220202271513552 1.10536585365854 0.733333333333333 5.1 5 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0090990116408973 0.0220202271513552 1.10536585365854 0.733333333333333 5.1 5 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0090990116408973 0.0220202271513552 1.10536585365854 0.733333333333333 5.1 5 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0090990116408973 0.0220202271513552 1.10536585365854 0.733333333333333 5.1 5 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.03680087904757e-17 1.31743984131122e-15 1.10408575423334 0.732484076433121 5.1 5 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.58333189485344e-05 8.90545962994642e-05 1.10291493158834 0.731707317073171 5.1 5 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 7.91868349429603e-11 1.31026588516084e-09 1.1021243115657 0.731182795698925 5.1 5 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00062034697810863 0.00219045595495926 1.1015009380863 0.730769230769231 5.1 5 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 3.53481483336788e-06 2.29546943944545e-05 1.09908536585366 0.729166666666667 5.1 5 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.79716000881329e-09 2.25356269435169e-08 1.09792231255646 0.728395061728395 5.1 5 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.79716000881329e-09 2.25356269435169e-08 1.09792231255646 0.728395061728395 5.1 5 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.01719061970212e-05 6.02776314912356e-05 1.09623059866962 0.727272727272727 5.1 5 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.01719061970212e-05 6.02776314912356e-05 1.09623059866962 0.727272727272727 5.1 5 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00184785188458945 0.00559890056905848 1.09623059866962 0.727272727272727 5.1 5 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00184785188458945 0.00559890056905848 1.09623059866962 0.727272727272727 5.1 5 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0287197160179747 0.0584666035673505 1.09623059866962 0.727272727272727 5.1 5 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0287197160179747 0.0584666035673505 1.09623059866962 0.727272727272727 5.1 5 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0287197160179747 0.0584666035673505 1.09623059866962 0.727272727272727 5.1 5 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0287197160179747 0.0584666035673505 1.09623059866962 0.727272727272727 5.1 5 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.4822726575419e-13 5.70074051805981e-12 1.0940204563336 0.725806451612903 5.1 5 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.4822726575419e-13 5.70074051805981e-12 1.0940204563336 0.725806451612903 5.1 5 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.4822726575419e-13 5.70074051805981e-12 1.0940204563336 0.725806451612903 5.1 5 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 2.2760246737619e-06 1.6694758302903e-05 1.093543758967 0.725490196078431 5.1 5 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 6.52384146096746e-06 4.03627234737248e-05 1.09039958484691 0.723404255319149 5.1 5 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 8.49601780764866e-05 0.00038999462388013 1.08861788617886 0.722222222222222 5.1 5 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 8.49601780764866e-05 0.00038999462388013 1.08861788617886 0.722222222222222 5.1 5 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00557210902616927 0.0143904013507058 1.08861788617886 0.722222222222222 5.1 5 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00557210902616927 0.0143904013507058 1.08861788617886 0.722222222222222 5.1 5 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.48179876958589e-15 4.65262056866232e-13 1.08742160278746 0.721428571428571 5.1 5 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00115334120110862 0.00370558282989841 1.08526829268293 0.72 5.1 5 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00115334120110862 0.00370558282989841 1.08526829268293 0.72 5.1 5 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00115334120110862 0.00370558282989841 1.08526829268293 0.72 5.1 5 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00115334120110862 0.00370558282989841 1.08526829268293 0.72 5.1 5 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00115334120110862 0.00370558282989841 1.08526829268293 0.72 5.1 5 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.15266424101858e-16 1.33184400650845e-14 1.08338414634146 0.71875 5.1 5 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.16294630251566e-18 2.3688803097262e-16 1.07900839664134 0.715846994535519 5.1 5 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 7.61759438562577e-06 4.69257004794176e-05 1.07665505226481 0.714285714285714 5.1 5 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000155722597369644 0.000651744870755893 1.07665505226481 0.714285714285714 5.1 5 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000155722597369644 0.000651744870755893 1.07665505226481 0.714285714285714 5.1 5 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000155722597369644 0.000651744870755893 1.07665505226481 0.714285714285714 5.1 5 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00342720606116541 0.00918439590402707 1.07665505226481 0.714285714285714 5.1 5 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 5.56188098257329e-11 9.53561040747204e-10 1.07665505226481 0.714285714285714 5.1 5 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000720718344265545 0.00247725170021708 1.07665505226481 0.714285714285714 5.1 5 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0170974454597921 0.0377204106810607 1.07665505226481 0.714285714285714 5.1 5 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0170974454597921 0.0377204106810607 1.07665505226481 0.714285714285714 5.1 5 1 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0951080607321568 0.161309619096376 1.07665505226481 0.714285714285714 5.1 5 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0951080607321568 0.161309619096376 1.07665505226481 0.714285714285714 5.1 5 1 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0951080607321568 0.161309619096376 1.07665505226481 0.714285714285714 5.1 5 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0951080607321568 0.161309619096376 1.07665505226481 0.714285714285714 5.1 5 1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0951080607321568 0.161309619096376 1.07665505226481 0.714285714285714 5.1 5 1 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0951080607321568 0.161309619096376 1.07665505226481 0.714285714285714 5.1 5 1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0951080607321568 0.161309619096376 1.07665505226481 0.714285714285714 5.1 5 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0951080607321568 0.161309619096376 1.07665505226481 0.714285714285714 5.1 5 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 3.58825922040303e-11 6.54627291106861e-10 1.07466124661247 0.712962962962963 5.1 5 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.89471124876814e-09 2.32428802327333e-08 1.07186991869919 0.711111111111111 5.1 5 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 9.82520297918541e-05 0.000442445058208254 1.07098844672657 0.710526315789474 5.1 5 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 3.09106846093151e-06 2.04585600925839e-05 1.06882483370288 0.709090909090909 5.1 5 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00211603928733251 0.00629942239722627 1.06768292682927 0.708333333333333 5.1 5 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 7.4431052116527e-11 1.24606337837433e-09 1.06480196912061 0.706422018348624 5.1 5 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 9.50425232284468e-09 1.05660555120375e-07 1.06398852223816 0.705882352941177 5.1 5 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0102985239581275 0.0244246659873591 1.06398852223816 0.705882352941177 5.1 5 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0102985239581275 0.0244246659873591 1.06398852223816 0.705882352941177 5.1 5 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0102985239581275 0.0244246659873591 1.06398852223816 0.705882352941177 5.1 5 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0102985239581275 0.0244246659873591 1.06398852223816 0.705882352941177 5.1 5 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.45278929856808e-13 8.94953633810866e-12 1.06271275662397 0.705035971223022 5.1 5 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.05762143328038e-12 3.20211765863401e-11 1.0619733924612 0.704545454545455 5.1 5 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.000177251557733399 0.000733223740275076 1.059195781147 0.702702702702703 5.1 5 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.26431518677898e-11 2.94937788653523e-10 1.0588591009877 0.702479338842975 5.1 5 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.26431518677898e-11 2.94937788653523e-10 1.0588591009877 0.702479338842975 5.1 5 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 5.45929614218974e-11 9.47387611016586e-10 1.05776636713736 0.701754385964912 5.1 5 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 5.07971142080503e-07 4.13053105817461e-06 1.05737167819439 0.701492537313433 5.1 5 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.79679940206595e-32 6.39211387284962e-30 1.0559280031303 0.700534759358289 5.1 5 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.96996416671231e-13 1.64471139749573e-11 1.05512195121951 0.7 5.1 5 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.000814348480985698 0.00276567515141444 1.05512195121951 0.7 5.1 5 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000814348480985698 0.00276567515141444 1.05512195121951 0.7 5.1 5 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.0062569128979543 0.0157865018684202 1.05512195121951 0.7 5.1 5 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0062569128979543 0.0157865018684202 1.05512195121951 0.7 5.1 5 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0062569128979543 0.0157865018684202 1.05512195121951 0.7 5.1 5 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0062569128979543 0.0157865018684202 1.05512195121951 0.7 5.1 5 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0062569128979543 0.0157865018684202 1.05512195121951 0.7 5.1 5 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0538733134569294 0.0987908827953744 1.05512195121951 0.7 5.1 5 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 7.96293173327771e-20 7.55416790430278e-18 1.05444602428087 0.699551569506726 5.1 5 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.05902504369784e-07 1.7865808763305e-06 1.05305713331106 0.698630136986301 5.1 5 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 9.89257329452931e-06 5.93971805827646e-05 1.05227795674183 0.69811320754717 5.1 5 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 9.89257329452931e-06 5.93971805827646e-05 1.05227795674183 0.69811320754717 5.1 5 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.91980265823609e-08 1.97962259613765e-07 1.05161656267725 0.697674418604651 5.1 5 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 5.89560014559335e-12 1.6133536552268e-10 1.05161656267725 0.697674418604651 5.1 5 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 8.39981377434033e-14 3.73529218777697e-12 1.05115532734275 0.697368421052632 5.1 5 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.80538402780107e-09 2.25356269435169e-08 1.05055432372506 0.696969696969697 5.1 5 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 4.40590405485656e-05 0.00022232629326457 1.04856839872747 0.695652173913043 5.1 5 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 3.96282564734727e-06 2.49517738768813e-05 1.04745762711864 0.694915254237288 5.1 5 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 3.96282564734727e-06 2.49517738768813e-05 1.04745762711864 0.694915254237288 5.1 5 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.31213910353814e-07 1.95843687162784e-06 1.04507317073171 0.693333333333333 5.1 5 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.15625164715446e-08 2.20744323302215e-07 1.04484478935698 0.693181818181818 5.1 5 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.82365065417148e-11 3.41454589590265e-10 1.04444017668523 0.692913385826772 5.1 5 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 7.59587579382999e-22 8.31456250355391e-20 1.04352720450281 0.692307692307692 5.1 5 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.29370419938225e-09 1.67358279610995e-08 1.04352720450281 0.692307692307692 5.1 5 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.75027537352458e-05 9.61637782442268e-05 1.04352720450281 0.692307692307692 5.1 5 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.000197946017875081 0.000811749808173603 1.04352720450281 0.692307692307692 5.1 5 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.000197946017875081 0.000811749808173603 1.04352720450281 0.692307692307692 5.1 5 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00235257820285861 0.00697441413055793 1.04352720450281 0.692307692307692 5.1 5 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00235257820285861 0.00697441413055793 1.04352720450281 0.692307692307692 5.1 5 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0314257860727392 0.0631622790699263 1.04352720450281 0.692307692307692 5.1 5 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0314257860727392 0.0631622790699263 1.04352720450281 0.692307692307692 5.1 5 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0314257860727392 0.0631622790699263 1.04352720450281 0.692307692307692 5.1 5 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0314257860727392 0.0631622790699263 1.04352720450281 0.692307692307692 5.1 5 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0314257860727392 0.0631622790699263 1.04352720450281 0.692307692307692 5.1 5 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0314257860727392 0.0631622790699263 1.04352720450281 0.692307692307692 5.1 5 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0314257860727392 0.0631622790699263 1.04352720450281 0.692307692307692 5.1 5 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0314257860727392 0.0631622790699263 1.04352720450281 0.692307692307692 5.1 5 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.55134774198475e-09 4.10859173727179e-08 1.0400487804878 0.69 5.1 5 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.77833999125131e-08 3.65753592350382e-07 1.03952901597981 0.689655172413793 5.1 5 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00145250908252106 0.0045728327974059 1.03952901597981 0.689655172413793 5.1 5 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00145250908252106 0.0045728327974059 1.03952901597981 0.689655172413793 5.1 5 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 7.77805892850153e-05 0.000359356423872003 1.03837398373984 0.688888888888889 5.1 5 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 2.78751649937512e-06 1.86227041249333e-05 1.03628048780488 0.6875 5.1 5 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000899958371620262 0.00300465064534114 1.03628048780488 0.6875 5.1 5 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0186662792009661 0.0405528477908012 1.03628048780488 0.6875 5.1 5 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0186662792009661 0.0405528477908012 1.03628048780488 0.6875 5.1 5 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0186662792009661 0.0405528477908012 1.03628048780488 0.6875 5.1 5 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0186662792009661 0.0405528477908012 1.03628048780488 0.6875 5.1 5 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.03726415502474e-07 9.58459021168961e-07 1.03514545988833 0.686746987951807 5.1 5 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.76372034206997e-06 1.32093370882399e-05 1.03487440844558 0.686567164179104 5.1 5 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.76372034206997e-06 1.32093370882399e-05 1.03487440844558 0.686567164179104 5.1 5 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.000559258336944279 0.00199955933033093 1.03358885017422 0.685714285714286 5.1 5 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.69081498229052e-08 1.75622607284628e-07 1.03132220795892 0.684210526315789 5.1 5 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.69081498229052e-08 1.75622607284628e-07 1.03132220795892 0.684210526315789 5.1 5 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.69081498229052e-08 1.75622607284628e-07 1.03132220795892 0.684210526315789 5.1 5 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.0749950608142e-08 1.18582788491365e-07 1.03051269288203 0.683673469387755 5.1 5 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000217536833004878 0.000869536273499836 1.02938726948245 0.682926829268293 5.1 5 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000217536833004878 0.000869536273499836 1.02938726948245 0.682926829268293 5.1 5 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.1430288429715e-07 1.02297487015625e-06 1.02852223816356 0.682352941176471 5.1 5 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.1430288429715e-07 1.02297487015625e-06 1.02852223816356 0.682352941176471 5.1 5 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00681153643954242 0.0171554271742812 1.02771618625277 0.681818181818182 5.1 5 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 4.37496248321034e-13 1.48227895562103e-11 1.02685975609756 0.68125 5.1 5 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.93829511762312e-06 1.44408060333911e-05 1.02672322375398 0.681159420289855 5.1 5 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.00255661345668572 0.0071756626210331 1.02282229965157 0.678571428571429 5.1 5 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00255661345668572 0.0071756626210331 1.02282229965157 0.678571428571429 5.1 5 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00255661345668572 0.0071756626210331 1.02282229965157 0.678571428571429 5.1 5 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 8.39455307027711e-06 5.12680215407911e-05 1.02108575924469 0.67741935483871 5.1 5 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00157745254601869 0.00487981515866218 1.02108575924469 0.67741935483871 5.1 5 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00157745254601869 0.00487981515866218 1.02108575924469 0.67741935483871 5.1 5 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00157745254601869 0.00487981515866218 1.02108575924469 0.67741935483871 5.1 5 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0009768332568567 0.00322513625175658 1.01965566714491 0.676470588235294 5.1 5 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0009768332568567 0.00322513625175658 1.01965566714491 0.676470588235294 5.1 5 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.59124779179977e-16 2.12931066988795e-14 1.01923344947735 0.676190476190476 5.1 5 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 3.30719279232102e-09 3.85748798645313e-08 1.01845748187212 0.675675675675676 5.1 5 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 3.38707266829441e-07 2.81859906841108e-06 1.01698501322363 0.674698795180723 5.1 5 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.1460143351068e-07 1.85077478718605e-06 1.01656267725468 0.674418604651163 5.1 5 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.000147471790007011 0.000622707291335243 1.01580063626723 0.673913043478261 5.1 5 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.000147471790007011 0.000622707291335243 1.01580063626723 0.673913043478261 5.1 5 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 3.61752771270666e-06 2.29809907820606e-05 1.01205574912892 0.671428571428571 5.1 5 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 5.78336996085028e-07 4.67598605357384e-06 1.01100535395598 0.670731707317073 5.1 5 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 6.33526891005326e-10 8.34730338796833e-09 1.00883426157096 0.669291338582677 5.1 5 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.73420162953606e-29 5.55824131261402e-27 1.00487804878049 0.666666666666667 5.1 5 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.01763773308059e-13 7.55552235308862e-12 1.00487804878049 0.666666666666667 5.1 5 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.68515596157875e-09 2.16033957957348e-08 1.00487804878049 0.666666666666667 5.1 5 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.55223292551739e-06 1.17490821968683e-05 1.00487804878049 0.666666666666667 5.1 5 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.54759053570211e-05 8.80888532921643e-05 1.00487804878049 0.666666666666667 5.1 5 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000158078603370365 0.00065966525687985 1.00487804878049 0.666666666666667 5.1 5 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00104468245567011 0.00342530676133311 1.00487804878049 0.666666666666667 5.1 5 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00443607963348894 0.0116253062954968 1.00487804878049 0.666666666666667 5.1 5 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0119163265715321 0.0276296888676636 1.00487804878049 0.666666666666667 5.1 5 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0119163265715321 0.0276296888676636 1.00487804878049 0.666666666666667 5.1 5 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0119163265715321 0.0276296888676636 1.00487804878049 0.666666666666667 5.1 5 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0197513538220439 0.0422649270507797 1.00487804878049 0.666666666666667 5.1 5 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0197513538220439 0.0422649270507797 1.00487804878049 0.666666666666667 5.1 5 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0197513538220439 0.0422649270507797 1.00487804878049 0.666666666666667 5.1 5 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0197513538220439 0.0422649270507797 1.00487804878049 0.666666666666667 5.1 5 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0197513538220439 0.0422649270507797 1.00487804878049 0.666666666666667 5.1 5 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0197513538220439 0.0422649270507797 1.00487804878049 0.666666666666667 5.1 5 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0330943130975815 0.0661421454183406 1.00487804878049 0.666666666666667 5.1 5 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0563025978025177 0.101995199224096 1.00487804878049 0.666666666666667 5.1 5 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0563025978025177 0.101995199224096 1.00487804878049 0.666666666666667 5.1 5 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0563025978025177 0.101995199224096 1.00487804878049 0.666666666666667 5.1 5 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0563025978025177 0.101995199224096 1.00487804878049 0.666666666666667 5.1 5 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0563025978025177 0.101995199224096 1.00487804878049 0.666666666666667 5.1 5 1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0980275113629704 0.162769134970253 1.00487804878049 0.666666666666667 5.1 5 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0980275113629704 0.162769134970253 1.00487804878049 0.666666666666667 5.1 5 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0980275113629704 0.162769134970253 1.00487804878049 0.666666666666667 5.1 5 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0980275113629704 0.162769134970253 1.00487804878049 0.666666666666667 5.1 5 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0980275113629704 0.162769134970253 1.00487804878049 0.666666666666667 5.1 5 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 5.01998216029688e-18 3.57171730705123e-16 0.9991028875806 0.662835249042146 5.1 5 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 6.64212025786732e-07 5.25096507052511e-06 0.999035734543392 0.662790697674419 5.1 5 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.43180928889078e-34 6.79154872697193e-32 0.997236390614857 0.661596958174905 5.1 5 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.49991657337428e-12 4.35588017124816e-11 0.996362133112857 0.661016949152542 5.1 5 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.52028496600491e-11 6.50566948912335e-10 0.995215759849906 0.66025641025641 5.1 5 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 2.78180713122164e-06 1.86227041249333e-05 0.992158073479469 0.658227848101266 5.1 5 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.56899819744997e-10 4.74643405137505e-09 0.990823810336005 0.657342657342657 5.1 5 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00177718518668883 0.00541527734616317 0.990522648083624 0.657142857142857 5.1 5 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 2.76767325068982e-05 0.000146408886086677 0.989176829268293 0.65625 5.1 5 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0028708505153248 0.00787133002564005 0.989176829268293 0.65625 5.1 5 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.17413223682012e-19 4.33105304293825e-17 0.987729959210855 0.655290102389078 5.1 5 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000110975581212394 0.000488910997105995 0.986607538802661 0.654545454545455 5.1 5 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000110975581212394 0.000488910997105995 0.986607538802661 0.654545454545455 5.1 5 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.27784322041396e-07 1.13648181415566e-06 0.985553470919324 0.653846153846154 5.1 5 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00757914014287981 0.0187985675795847 0.985553470919324 0.653846153846154 5.1 5 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00757914014287981 0.0187985675795847 0.985553470919324 0.653846153846154 5.1 5 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00757914014287981 0.0187985675795847 0.985553470919324 0.653846153846154 5.1 5 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00757914014287981 0.0187985675795847 0.985553470919324 0.653846153846154 5.1 5 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00028175176653477 0.0010924598468092 0.984370333499254 0.653061224489796 5.1 5 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.16009698847829e-05 6.73803271267185e-05 0.983943089430894 0.652777777777778 5.1 5 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.83618269714928e-05 9.97285487802833e-05 0.983032873806999 0.652173913043478 5.1 5 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.83618269714928e-05 9.97285487802833e-05 0.983032873806999 0.652173913043478 5.1 5 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0124082547575156 0.0284330861834858 0.983032873806999 0.652173913043478 5.1 5 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000719735287711268 0.00247725170021708 0.981508791832104 0.651162790697674 5.1 5 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000719735287711268 0.00247725170021708 0.981508791832104 0.651162790697674 5.1 5 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 4.61032467553444e-05 0.000231003239904419 0.980952380952381 0.650793650793651 5.1 5 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00115360027663036 0.00370558282989841 0.979756097560976 0.65 5.1 5 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00115360027663036 0.00370558282989841 0.979756097560976 0.65 5.1 5 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0204521308597049 0.0435679374451498 0.979756097560976 0.65 5.1 5 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0204521308597049 0.0435679374451498 0.979756097560976 0.65 5.1 5 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 7.31457204469971e-05 0.000339043518553997 0.979756097560976 0.65 5.1 5 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00185318493888021 0.00559890056905848 0.977719182597231 0.648648648648649 5.1 5 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00185318493888021 0.00559890056905848 0.977719182597231 0.648648648648649 5.1 5 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.58005763335955e-13 9.1785550306766e-12 0.976167247386759 0.647619047619048 5.1 5 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.66052339545452e-09 3.15493732644315e-08 0.975960694858747 0.647482014388489 5.1 5 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 3.03870797573617e-05 0.00016015116479528 0.97532281205165 0.647058823529412 5.1 5 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0340071638128369 0.067118161034212 0.97532281205165 0.647058823529412 5.1 5 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0340071638128369 0.067118161034212 0.97532281205165 0.647058823529412 5.1 5 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0340071638128369 0.067118161034212 0.97532281205165 0.647058823529412 5.1 5 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0340071638128369 0.067118161034212 0.97532281205165 0.647058823529412 5.1 5 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0340071638128369 0.067118161034212 0.97532281205165 0.647058823529412 5.1 5 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0340071638128369 0.067118161034212 0.97532281205165 0.647058823529412 5.1 5 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000468438783780578 0.00173139841381756 0.973475609756098 0.645833333333333 5.1 5 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.60975040101667e-08 1.70945882137815e-07 0.973228346456693 0.645669291338583 5.1 5 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.15179837369569e-13 4.9666941992999e-12 0.97290465631929 0.645454545454546 5.1 5 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00482224435754285 0.0125909242583183 0.972462627852085 0.645161290322581 5.1 5 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 1.26625623608448e-05 7.23647640139845e-05 0.971822849807445 0.644736842105263 5.1 5 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.26625623608448e-05 7.23647640139845e-05 0.971822849807445 0.644736842105263 5.1 5 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000120818555321745 0.000526113316240955 0.970814386109963 0.644067796610169 5.1 5 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000120818555321745 0.000526113316240955 0.970814386109963 0.644067796610169 5.1 5 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00119529667148171 0.00383087198990648 0.968989547038328 0.642857142857143 5.1 5 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.057216799176044 0.102672768256634 0.968989547038327 0.642857142857143 5.1 5 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.057216799176044 0.102672768256634 0.968989547038327 0.642857142857143 5.1 5 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.057216799176044 0.102672768256634 0.968989547038327 0.642857142857143 5.1 5 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.057216799176044 0.102672768256634 0.968989547038327 0.642857142857143 5.1 5 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 8.3350024546896e-06 5.11237435044108e-05 0.967660343270099 0.641975308641975 5.1 5 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 4.99195992707152e-05 0.000248376187979817 0.967382599199126 0.641791044776119 5.1 5 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000304541522469768 0.00117125023371481 0.966958122411413 0.641509433962264 5.1 5 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.41536589898282e-10 2.26299513960961e-09 0.966456241032999 0.641176470588235 5.1 5 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00191453516149364 0.00574764458819716 0.966228893058161 0.641025641025641 5.1 5 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 9.29336112484023e-07 7.30632755836887e-06 0.964682926829268 0.64 5.1 5 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0127340191501333 0.0290858896478969 0.964682926829268 0.64 5.1 5 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0127340191501333 0.0290858896478969 0.964682926829268 0.64 5.1 5 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.69684693682395e-08 6.2694823625661e-07 0.963694522191124 0.639344262295082 5.1 5 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000124946658541362 0.000535539443085417 0.963694522191124 0.639344262295082 5.1 5 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000124946658541362 0.000535539443085417 0.963694522191124 0.639344262295082 5.1 5 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000124946658541362 0.000535539443085417 0.963694522191124 0.639344262295082 5.1 5 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.29394553389161e-10 3.44057755640023e-09 0.963255881079521 0.63905325443787 5.1 5 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 3.26689225262141e-05 0.000170285262838105 0.963008130081301 0.638888888888889 5.1 5 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.04901409140189e-07 9.63062614235415e-07 0.962656282025005 0.638655462184874 5.1 5 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000197881415304722 0.000811749808173603 0.961564339781329 0.637931034482759 5.1 5 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0208497093025141 0.0442822930410112 0.95920177383592 0.636363636363636 5.1 5 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0978921089751002 0.162769134970253 0.95920177383592 0.636363636363636 5.1 5 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0978921089751002 0.162769134970253 0.95920177383592 0.636363636363636 5.1 5 1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0978921089751002 0.162769134970253 0.95920177383592 0.636363636363636 5.1 5 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0978921089751002 0.162769134970253 0.95920177383592 0.636363636363636 5.1 5 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0978921089751002 0.162769134970253 0.95920177383592 0.636363636363636 5.1 5 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0978921089751002 0.162769134970253 0.95920177383592 0.636363636363636 5.1 5 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0978921089751002 0.162769134970253 0.95920177383592 0.636363636363636 5.1 5 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 4.03251576880091e-07 3.29785628678373e-06 0.95920177383592 0.636363636363636 5.1 5 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.000313634369305496 0.00118382415788255 0.95920177383592 0.636363636363636 5.1 5 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000313634369305496 0.00118382415788255 0.95920177383592 0.636363636363636 5.1 5 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.000313634369305496 0.00118382415788255 0.95920177383592 0.636363636363636 5.1 5 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0049451516922685 0.0128411512009089 0.95920177383592 0.636363636363636 5.1 5 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 6.31724972383374e-07 5.07878325255108e-06 0.957921130613175 0.635514018691589 5.1 5 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 3.36446894398867e-05 0.000174095974810759 0.957350032959789 0.635135135135135 5.1 5 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 3.36446894398867e-05 0.000174095974810759 0.957350032959789 0.635135135135135 5.1 5 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.000497520933848099 0.00182938575934327 0.95656660412758 0.634615384615385 5.1 5 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.000497520933848099 0.00182938575934327 0.95656660412758 0.634615384615385 5.1 5 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.11613690775196e-07 1.01163236925544e-06 0.955859607376562 0.634146341463415 5.1 5 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 5.2999284175403e-05 0.000260961873292728 0.955341806939196 0.633802816901408 5.1 5 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.000203162542832675 0.000830747984054299 0.954634146341463 0.633333333333333 5.1 5 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 6.49781726269382e-07 5.19460335101871e-06 0.954173193108078 0.63302752293578 5.1 5 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.26489051340879e-09 2.75464888938522e-08 0.953998147576413 0.632911392405063 5.1 5 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.19515192205207e-05 0.000117875516418117 0.953998147576413 0.632911392405063 5.1 5 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.82891651269342e-08 4.64293797132617e-07 0.95198973042362 0.631578947368421 5.1 5 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 3.45105406384884e-05 0.00017728700118617 0.95198973042362 0.631578947368421 5.1 5 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0031383159775029 0.00847404864513591 0.95198973042362 0.631578947368421 5.1 5 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0129223430088443 0.0291880858755324 0.949051490514905 0.62962962962963 5.1 5 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0129223430088443 0.0291880858755324 0.949051490514905 0.62962962962963 5.1 5 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0129223430088443 0.0291880858755324 0.949051490514905 0.62962962962963 5.1 5 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0129223430088443 0.0291880858755324 0.949051490514905 0.62962962962963 5.1 5 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0129223430088443 0.0291880858755324 0.949051490514905 0.62962962962963 5.1 5 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 9.34107356093919e-06 5.68049046034891e-05 0.948424225815292 0.629213483146067 5.1 5 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000207597610603137 0.000836859489768454 0.948151062155783 0.629032258064516 5.1 5 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.84862208905686e-44 6.89958923272792e-41 0.946335945259905 0.627828054298643 5.1 5 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.87751822114734e-09 4.44976486184892e-08 0.943229088732605 0.625766871165644 5.1 5 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00318275996959912 0.00857777923624916 0.942073170731707 0.625 5.1 5 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0210090436280327 0.0444879004206704 0.942073170731707 0.625 5.1 5 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 8.68832202573849e-05 0.000397539621949385 0.942073170731707 0.625 5.1 5 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000516817720285693 0.00186657770549883 0.942073170731707 0.625 5.1 5 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0571410362586075 0.102672768256634 0.942073170731707 0.625 5.1 5 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0571410362586075 0.102672768256634 0.942073170731707 0.625 5.1 5 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.171840924646193 0.26495374241454 0.942073170731707 0.625 5.1 5 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.171840924646193 0.26495374241454 0.942073170731707 0.625 5.1 5 1 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.171840924646193 0.26495374241454 0.942073170731707 0.625 5.1 5 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.171840924646193 0.26495374241454 0.942073170731707 0.625 5.1 5 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.171840924646193 0.26495374241454 0.942073170731707 0.625 5.1 5 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.171840924646193 0.26495374241454 0.942073170731707 0.625 5.1 5 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.171840924646193 0.26495374241454 0.942073170731707 0.625 5.1 5 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.171840924646193 0.26495374241454 0.942073170731707 0.625 5.1 5 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.000523153927663034 0.00187518397749244 0.935576114381834 0.620689655172414 5.1 5 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000523153927663034 0.00187518397749244 0.935576114381834 0.620689655172414 5.1 5 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.000523153927663034 0.00187518397749244 0.935576114381834 0.620689655172414 5.1 5 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0129977301803211 0.0292192259819857 0.935576114381834 0.620689655172414 5.1 5 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.00013805585307525 0.000589950387165409 0.934111989007214 0.619718309859155 5.1 5 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.32575181572989e-08 2.29829502346086e-07 0.933564122738001 0.619354838709677 5.1 5 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 3.69151083458692e-05 0.000187607854200614 0.933101045296167 0.619047619047619 5.1 5 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 3.69151083458692e-05 0.000187607854200614 0.933101045296167 0.619047619047619 5.1 5 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00320882142216935 0.0086153827995226 0.933101045296167 0.619047619047619 5.1 5 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00320882142216935 0.0086153827995226 0.933101045296167 0.619047619047619 5.1 5 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 2.70752242310212e-06 1.83466876574968e-05 0.93179600886918 0.618181818181818 5.1 5 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000823534851992822 0.00279021451044235 0.93179600886918 0.618181818181818 5.1 5 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00811183632925953 0.0199019708560971 0.930989956958393 0.617647058823529 5.1 5 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00811183632925953 0.0199019708560971 0.930989956958393 0.617647058823529 5.1 5 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00013930491414874 0.000593505667166636 0.929168058803876 0.616438356164384 5.1 5 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0209818255617391 0.0444879004206704 0.927579737335835 0.615384615384615 5.1 5 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0961054965701633 0.161843930910464 0.927579737335835 0.615384615384615 5.1 5 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0961054965701633 0.161843930910464 0.927579737335835 0.615384615384615 5.1 5 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0961054965701633 0.161843930910464 0.927579737335835 0.615384615384615 5.1 5 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0961054965701633 0.161843930910464 0.927579737335835 0.615384615384615 5.1 5 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0961054965701633 0.161843930910464 0.927579737335835 0.615384615384615 5.1 5 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0961054965701633 0.161843930910464 0.927579737335835 0.615384615384615 5.1 5 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.83681939328686e-09 2.27286434491061e-08 0.926959697404461 0.614973262032086 5.1 5 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.83499064106355e-09 3.33404271258962e-08 0.925689289501591 0.614130434782609 5.1 5 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0129808548100504 0.0292192259819857 0.923839496459481 0.612903225806452 5.1 5 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0129808548100504 0.0292192259819857 0.923839496459481 0.612903225806452 5.1 5 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 5.8338738072195e-05 0.000277468588069871 0.922123385939742 0.611764705882353 5.1 5 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 5.8338738072195e-05 0.000277468588069871 0.922123385939742 0.611764705882353 5.1 5 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 5.8338738072195e-05 0.000277468588069871 0.922123385939742 0.611764705882353 5.1 5 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 5.8338738072195e-05 0.000277468588069871 0.922123385939742 0.611764705882353 5.1 5 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 5.8338738072195e-05 0.000277468588069871 0.922123385939742 0.611764705882353 5.1 5 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00129932931965071 0.00410876804858437 0.921138211382114 0.611111111111111 5.1 5 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.00129932931965071 0.00410876804858437 0.921138211382114 0.611111111111111 5.1 5 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.000218469990360464 0.000870820157655296 0.921138211382114 0.611111111111111 5.1 5 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0081012368256006 0.0199019708560971 0.921138211382114 0.611111111111111 5.1 5 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.0564091509412255 0.101995199224096 0.921138211382114 0.611111111111111 5.1 5 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0564091509412255 0.101995199224096 0.921138211382114 0.611111111111111 5.1 5 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0564091509412255 0.101995199224096 0.921138211382114 0.611111111111111 5.1 5 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 9.0639760139948e-05 0.000410765537194732 0.919095776323617 0.609756097560976 5.1 5 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00508964473559351 0.0131922849886149 0.919095776323617 0.609756097560976 5.1 5 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 5.84965400006756e-05 0.000277468588069871 0.91825063078217 0.609195402298851 5.1 5 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 5.84965400006756e-05 0.000277468588069871 0.91825063078217 0.609195402298851 5.1 5 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.77941832494368e-05 0.000191391895957112 0.917497348886532 0.608695652173913 5.1 5 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0339808608169563 0.067118161034212 0.917497348886532 0.608695652173913 5.1 5 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0339808608169563 0.067118161034212 0.917497348886532 0.608695652173913 5.1 5 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0339808608169563 0.067118161034212 0.917497348886532 0.608695652173913 5.1 5 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.000340384876085069 0.00127465178597119 0.917497348886532 0.608695652173913 5.1 5 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00203870005933708 0.00608190814347308 0.916212338593974 0.607843137254902 5.1 5 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.02503131773441e-05 6.02776314912356e-05 0.915659904262594 0.607476635514019 5.1 5 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0208091441334682 0.0442622004513083 0.915156794425087 0.607142857142857 5.1 5 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.37652655967659e-07 1.21664428224831e-06 0.91411487018096 0.606451612903226 5.1 5 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0128890531750414 0.0291880858755324 0.913525498891352 0.606060606060606 5.1 5 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0128890531750414 0.0291880858755324 0.913525498891352 0.606060606060606 5.1 5 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00805061765589651 0.0198544695395853 0.912323491655969 0.605263157894737 5.1 5 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000140532325204457 0.000596947757510277 0.911833785004517 0.604938271604938 5.1 5 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.13991723036055e-22 3.72341851566922e-20 0.911729240887915 0.604868913857678 5.1 5 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 4.11228816782587e-11 7.2244272380447e-10 0.90917537746806 0.603174603174603 5.1 5 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 4.11228816782587e-11 7.2244272380447e-10 0.90917537746806 0.603174603174603 5.1 5 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 4.11228816782587e-11 7.2244272380447e-10 0.90917537746806 0.603174603174603 5.1 5 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 9.02482887914201e-05 0.000410298130831281 0.907815964523282 0.602272727272727 5.1 5 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.14070000592758e-30 2.7053601807249e-28 0.905162237281784 0.600512163892446 5.1 5 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0552406795690251 0.100908199007346 0.904390243902439 0.6 5.1 5 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0552406795690251 0.100908199007346 0.904390243902439 0.6 5.1 5 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.164258808222032 0.256857455054892 0.904390243902439 0.6 5.1 5 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.164258808222032 0.256857455054892 0.904390243902439 0.6 5.1 5 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.164258808222032 0.256857455054892 0.904390243902439 0.6 5.1 5 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.164258808222032 0.256857455054892 0.904390243902439 0.6 5.1 5 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.164258808222032 0.256857455054892 0.904390243902439 0.6 5.1 5 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.164258808222032 0.256857455054892 0.904390243902439 0.6 5.1 5 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00201302102113756 0.00601791788461923 0.904390243902439 0.6 5.1 5 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.55774289719065e-05 8.83134718208084e-05 0.901698606271777 0.598214285714286 5.1 5 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0019917745657091 0.00596693727790325 0.899101412066752 0.596491228070175 5.1 5 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 5.7058669812395e-05 0.000277468588069871 0.89830007390983 0.595959595959596 5.1 5 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00785556137298205 0.0194070552669331 0.897212543554007 0.595238095238095 5.1 5 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.47210943002572e-13 1.76972993611968e-11 0.896992368696693 0.595092024539877 5.1 5 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0201515825224147 0.0430566095035978 0.894969512195122 0.59375 5.1 5 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00309016780900907 0.00835990264680592 0.893224932249322 0.592592592592593 5.1 5 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 5.75485743148772e-11 9.74900252977026e-10 0.892418772563177 0.592057761732852 5.1 5 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00487450328882072 0.0126808376233855 0.892085614733699 0.591836734693878 5.1 5 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00487450328882072 0.0126808376233855 0.892085614733699 0.591836734693878 5.1 5 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0537839623647779 0.0987908827953744 0.890687361419069 0.590909090909091 5.1 5 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0537839623647779 0.0987908827953744 0.890687361419069 0.590909090909091 5.1 5 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0197136486690156 0.0422649270507797 0.886657101865136 0.588235294117647 5.1 5 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0197136486690156 0.0422649270507797 0.886657101865136 0.588235294117647 5.1 5 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0901894254668512 0.154625966794373 0.886657101865136 0.588235294117647 5.1 5 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00298351452631165 0.00808674508750757 0.883599663582843 0.586206896551724 5.1 5 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00298351452631165 0.00808674508750757 0.883599663582843 0.586206896551724 5.1 5 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00298351452631165 0.00808674508750757 0.883599663582843 0.586206896551724 5.1 5 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.012028601749116 0.0276296888676636 0.882331945270672 0.585365853658537 5.1 5 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.012028601749116 0.0276296888676636 0.882331945270672 0.585365853658537 5.1 5 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.012028601749116 0.0276296888676636 0.882331945270672 0.585365853658537 5.1 5 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.012028601749116 0.0276296888676636 0.882331945270672 0.585365853658537 5.1 5 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0521414048814492 0.0977565469648251 0.879268292682927 0.583333333333333 5.1 5 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0521414048814492 0.0977565469648251 0.879268292682927 0.583333333333333 5.1 5 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.156117424616716 0.25121310739653 0.879268292682927 0.583333333333333 5.1 5 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.18438994668471e-05 0.000166595106401924 0.875216365066876 0.580645161290323 5.1 5 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.3238151433242e-21 6.42770639210738e-19 0.874384554109927 0.580093312597201 5.1 5 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00722754479800813 0.0181710181052395 0.874243902439025 0.58 5.1 5 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.00112295400931904 0.00366505402582798 0.872657252888318 0.578947368421053 5.1 5 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0187039309970261 0.0405727039767806 0.872657252888318 0.578947368421053 5.1 5 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0867163517631902 0.149030638356304 0.872657252888318 0.578947368421053 5.1 5 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0867163517631902 0.149030638356304 0.872657252888318 0.578947368421053 5.1 5 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.73096214379635e-07 3.06887811018624e-06 0.871417682926829 0.578125 5.1 5 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0503848823218942 0.0947129293844854 0.869606003752345 0.576923076923077 5.1 5 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.82344252622031e-05 9.97285487802833e-05 0.865905552672548 0.574468085106383 5.1 5 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 4.11926720857715e-15 2.09347044207332e-13 0.861759053954176 0.571717171717172 5.1 5 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00413327012915967 0.0108517405789561 0.861324041811847 0.571428571428571 5.1 5 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0831311685570776 0.145326354860837 0.861324041811847 0.571428571428571 5.1 5 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00257958861099983 0.00722589486900149 0.861324041811847 0.571428571428571 5.1 5 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.029016095230803 0.058985576447761 0.861324041811847 0.571428571428571 5.1 5 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.147957093095656 0.239798341087834 0.861324041811847 0.571428571428571 5.1 5 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.147957093095656 0.239798341087834 0.861324041811847 0.571428571428571 5.1 5 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.147957093095656 0.239798341087834 0.861324041811847 0.571428571428571 5.1 5 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.000100452016100459 0.000450924980791651 0.859544446684136 0.570247933884298 5.1 5 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00250687092966856 0.00707793121610785 0.858333333333333 0.569444444444444 5.1 5 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0280077690306212 0.0573454033533439 0.855504284772577 0.567567567567568 5.1 5 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 3.76417170377735e-13 1.30644300840858e-11 0.855047577381603 0.567264573991031 5.1 5 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 9.50383940915628e-06 5.75487807626783e-05 0.854759071980964 0.567073170731707 5.1 5 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0467197304663242 0.0894780302201605 0.854146341463415 0.566666666666667 5.1 5 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0467197304663242 0.0894780302201605 0.854146341463415 0.566666666666667 5.1 5 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0164432963220586 0.036390063244618 0.851961823966066 0.565217391304348 5.1 5 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0164432963220586 0.036390063244618 0.851961823966066 0.565217391304348 5.1 5 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0795279943769459 0.139198445262477 0.851961823966066 0.565217391304348 5.1 5 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0158677816840161 0.0352259802439235 0.847865853658537 0.5625 5.1 5 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.140019875196048 0.228758073942567 0.847865853658537 0.5625 5.1 5 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.140019875196048 0.228758073942567 0.847865853658537 0.5625 5.1 5 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.90007896596509e-15 1.52844902539567e-13 0.844731109307591 0.560420315236427 5.1 5 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0759666361098081 0.133128723133321 0.84409756097561 0.56 5.1 5 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0430472223481639 0.0828906595418637 0.842324246771879 0.558823529411765 5.1 5 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.32930761882058e-38 9.45802370790846e-36 0.841723220330977 0.558424790187218 5.1 5 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0249893368825702 0.0518671761563121 0.841293250141804 0.558139534883721 5.1 5 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0147332236426145 0.0329126801309897 0.8406191369606 0.557692307692308 5.1 5 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 7.42907461529882e-13 2.34923848390449e-11 0.839440809042237 0.556910569105691 5.1 5 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0141792797612119 0.03172502374246 0.83739837398374 0.555555555555556 5.1 5 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.264107691250221 0.380775323859235 0.83739837398374 0.555555555555556 5.1 5 1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.264107691250221 0.380775323859235 0.83739837398374 0.555555555555556 5.1 5 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.264107691250221 0.380775323859235 0.83739837398374 0.555555555555556 5.1 5 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.264107691250221 0.380775323859235 0.83739837398374 0.555555555555556 5.1 5 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.264107691250221 0.380775323859235 0.83739837398374 0.555555555555556 5.1 5 1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.264107691250221 0.380775323859235 0.83739837398374 0.555555555555556 5.1 5 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 5.79585683330695e-05 0.000277468588069871 0.835264874941743 0.554140127388535 5.1 5 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0377973007976155 0.0741869779793198 0.829024390243903 0.55 5.1 5 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.125186617778281 0.205705031291563 0.829024390243903 0.55 5.1 5 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000334736692071802 0.00125680821324057 0.828449078383914 0.549618320610687 5.1 5 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000334736692071802 0.00125680821324057 0.828449078383914 0.549618320610687 5.1 5 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.32317127420489e-22 3.00533883926687e-20 0.826836592690251 0.548548548548549 5.1 5 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0658472659359114 0.115679826452842 0.826593233674272 0.548387096774194 5.1 5 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 3.5243871925714e-05 0.000180402984713277 0.82291364535267 0.545945945945946 5.1 5 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.118347815987838 0.195143617787593 0.822172949002217 0.545454545454545 5.1 5 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.24389884731835 0.354151081361237 0.822172949002217 0.545454545454545 5.1 5 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0111310662649993 0.0262678396270215 0.822172949002217 0.545454545454545 5.1 5 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0627133645619256 0.111714069000283 0.822172949002217 0.545454545454545 5.1 5 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0597091858000299 0.106875687287349 0.818257839721254 0.542857142857143 5.1 5 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0315377542380775 0.063297918590669 0.816463414634146 0.541666666666667 5.1 5 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.111893963780714 0.184930441881483 0.816463414634146 0.541666666666667 5.1 5 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.226131340671027 0.333110660222434 0.811632270168855 0.538461538461538 5.1 5 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.226131340671027 0.333110660222434 0.811632270168855 0.538461538461538 5.1 5 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.226131340671027 0.333110660222434 0.811632270168855 0.538461538461538 5.1 5 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.100084678438142 0.165798017948168 0.807491289198606 0.535714285714286 5.1 5 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0466027237020492 0.0894780302201605 0.80390243902439 0.533333333333333 5.1 5 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.094692846287413 0.161309619096376 0.80390243902439 0.533333333333333 5.1 5 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.210307452869277 0.311736984826022 0.80390243902439 0.533333333333333 5.1 5 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.210307452869277 0.311736984826022 0.80390243902439 0.533333333333333 5.1 5 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.210307452869277 0.311736984826022 0.80390243902439 0.533333333333333 5.1 5 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.196079131141394 0.291862556081804 0.797991391678623 0.529411764705882 5.1 5 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000160245334296895 0.000666751785685617 0.795740992942924 0.527918781725888 5.1 5 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 2.70741555845536e-05 0.000143755684316492 0.792080344332855 0.525490196078431 5.1 5 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00074138696769025 0.00254215338559814 0.790422367638311 0.524390243902439 5.1 5 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.171447611921605 0.26495374241454 0.789547038327526 0.523809523809524 5.1 5 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.171447611921605 0.26495374241454 0.789547038327526 0.523809523809524 5.1 5 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.00601268943347906 0.0153060054809315 0.78887622521085 0.523364485981308 5.1 5 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.058258761602998 0.104410853603358 0.785060975609756 0.520833333333333 5.1 5 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.150815235424196 0.243875090918899 0.783804878048781 0.52 5.1 5 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.150815235424196 0.243875090918899 0.783804878048781 0.52 5.1 5 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0191810590621934 0.0415443638439897 0.781571815718157 0.518518518518518 5.1 5 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.141702541419819 0.230448818789032 0.781571815718157 0.518518518518518 5.1 5 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.141702541419819 0.230448818789032 0.781571815718157 0.518518518518518 5.1 5 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.141702541419819 0.230448818789032 0.781571815718157 0.518518518518518 5.1 5 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.141702541419819 0.230448818789032 0.781571815718157 0.518518518518518 5.1 5 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.133274850497403 0.218490912739406 0.779646761984861 0.517241379310345 5.1 5 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.033002115610312 0.0660506476982756 0.775191637630662 0.514285714285714 5.1 5 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.099259779153496 0.164623153537791 0.772983114446529 0.512820512820513 5.1 5 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0181359215941378 0.0399495610347648 0.76969382459782 0.51063829787234 5.1 5 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.00109701677519623 0.00358863188759596 0.769359756097561 0.510416666666667 5.1 5 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0749966943402478 0.131590993891705 0.769039323046292 0.510204081632653 5.1 5 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0542626356800079 0.0993767446237467 0.766013594562175 0.508196721311475 5.1 5 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0323005410394158 0.0647375632381531 0.762962962962963 0.506172839506173 5.1 5 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.100241155310023 0.165864144193213 0.753658536585366 0.5 5.1 5 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.331680270019984 0.452956837081033 0.753658536585366 0.5 5.1 5 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.363956574278411 0.487215621070723 0.753658536585366 0.5 5.1 5 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.363956574278411 0.487215621070723 0.753658536585366 0.5 5.1 5 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.161305969192114 0.254477155388446 0.753658536585366 0.5 5.1 5 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.171856854707393 0.26495374241454 0.753658536585366 0.5 5.1 5 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.224547407855373 0.331807851898438 0.753658536585366 0.5 5.1 5 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.280595030542505 0.401696909921514 0.753658536585366 0.5 5.1 5 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.280595030542505 0.401696909921514 0.753658536585366 0.5 5.1 5 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.280595030542505 0.401696909921514 0.753658536585366 0.5 5.1 5 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.280595030542505 0.401696909921514 0.753658536585366 0.5 5.1 5 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.259743493658904 0.376773691617351 0.753658536585366 0.5 5.1 5 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.304305588246398 0.426207531569513 0.753658536585366 0.5 5.1 5 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.304305588246398 0.426207531569513 0.753658536585366 0.5 5.1 5 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.304305588246398 0.426207531569513 0.753658536585366 0.5 5.1 5 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.304305588246398 0.426207531569513 0.753658536585366 0.5 5.1 5 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.304305588246398 0.426207531569513 0.753658536585366 0.5 5.1 5 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.304305588246398 0.426207531569513 0.753658536585366 0.5 5.1 5 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0363464250265368 0.0714377939402788 0.745725288831836 0.494736842105263 5.1 5 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0105684208418797 0.025023066319459 0.739787520574592 0.49079754601227 5.1 5 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0110852825726509 0.0262032509981433 0.739615209816694 0.490683229813665 5.1 5 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0116281064641459 0.0273500752040984 0.739438564196963 0.490566037735849 5.1 5 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0116281064641459 0.0273500752040984 0.739438564196963 0.490566037735849 5.1 5 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.036111677368713 0.071074573852944 0.739165103189493 0.490384615384615 5.1 5 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0132974262967985 0.0298458006630035 0.735049683830172 0.487654320987654 5.1 5 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.170750108245841 0.26495374241454 0.720890774125133 0.478260869565217 5.1 5 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.170750108245841 0.26495374241454 0.720890774125133 0.478260869565217 5.1 5 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0878387016122517 0.150777409401971 0.713139260424862 0.473118279569892 5.1 5 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.162881691031861 0.256678456631604 0.712549889135255 0.472727272727273 5.1 5 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.0135309542630796 0.0303221227029327 0.711608918664294 0.472103004291845 5.1 5 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0403347898116402 0.0779202818799464 0.709897718332022 0.470967741935484 5.1 5 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.217348680662793 0.321838889264469 0.703414634146342 0.466666666666667 5.1 5 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.119908320245832 0.197487893182661 0.702272727272727 0.465909090909091 5.1 5 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0647118000651718 0.11382557662885 0.700583991755411 0.464788732394366 5.1 5 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.163537251015075 0.256857455054892 0.699045599151644 0.463768115942029 5.1 5 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.32182756614387 0.440770574227841 0.695684803001876 0.461538461538462 5.1 5 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.422150780890518 0.552132868756625 0.695684803001876 0.461538461538462 5.1 5 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.276849190704247 0.398741293898931 0.692551087673039 0.459459459459459 5.1 5 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.202585993472589 0.301232882666139 0.691883246701319 0.459016393442623 5.1 5 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.371313489533108 0.496596894366177 0.685144124168514 0.454545454545455 5.1 5 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.464004680078462 0.59324228189726 0.685144124168514 0.454545454545455 5.1 5 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.464004680078462 0.59324228189726 0.685144124168514 0.454545454545455 5.1 5 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.464004680078462 0.59324228189726 0.685144124168514 0.454545454545455 5.1 5 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.464004680078462 0.59324228189726 0.685144124168514 0.454545454545455 5.1 5 1 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.464004680078462 0.59324228189726 0.685144124168514 0.454545454545455 5.1 5 1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.464004680078462 0.59324228189726 0.685144124168514 0.454545454545455 5.1 5 1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.464004680078462 0.59324228189726 0.685144124168514 0.454545454545455 5.1 5 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.115616399991802 0.19086094801431 0.682143492967776 0.452554744525547 5.1 5 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.124887407124254 0.205450613107299 0.678292682926829 0.45 5.1 5 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.136268427043819 0.223141509416978 0.676076040172166 0.448529411764706 5.1 5 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.152844396125043 0.246875795330233 0.67114117856507 0.445255474452555 5.1 5 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.217777926087692 0.322139281520567 0.669918699186992 0.444444444444444 5.1 5 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.432501699091164 0.564632952116263 0.669918699186992 0.444444444444444 5.1 5 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.228869240577821 0.336795169950609 0.663219512195122 0.44 5.1 5 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.323614653954059 0.442791973631372 0.663219512195122 0.44 5.1 5 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.409501290711699 0.536081266497468 0.663219512195122 0.44 5.1 5 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.468966454824947 0.599047814376929 0.659451219512195 0.4375 5.1 5 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.330639033982226 0.451968631466578 0.657738359201774 0.436363636363636 5.1 5 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.280585814468787 0.401696909921514 0.656126255380201 0.435294117647059 5.1 5 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.280585814468787 0.401696909921514 0.656126255380201 0.435294117647059 5.1 5 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.129585137915241 0.212687025667113 0.656126255380201 0.435294117647059 5.1 5 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.471877133855932 0.602225256930037 0.645993031358885 0.428571428571429 5.1 5 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.510534675373608 0.648652538443433 0.645993031358885 0.428571428571429 5.1 5 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.447475941809267 0.583111964463907 0.639467849223947 0.424242424242424 5.1 5 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.447475941809267 0.583111964463907 0.639467849223947 0.424242424242424 5.1 5 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0102776782763927 0.0244246659873591 0.63822010707912 0.423414634146341 5.1 5 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.473795355394773 0.604131532909284 0.637711069418386 0.423076923076923 5.1 5 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.236995076636904 0.348392555841234 0.635226480836237 0.421428571428571 5.1 5 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.508036804372207 0.646055739608266 0.634659820282413 0.421052631578947 5.1 5 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.558522115834517 0.6923144345231 0.628048780487805 0.416666666666667 5.1 5 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.558522115834517 0.6923144345231 0.628048780487805 0.416666666666667 5.1 5 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.558522115834517 0.6923144345231 0.628048780487805 0.416666666666667 5.1 5 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.548238781084186 0.681943868429018 0.620659971305595 0.411764705882353 5.1 5 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.499125164140629 0.635290794787223 0.61234756097561 0.40625 5.1 5 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.426192797724788 0.556907576824953 0.609919537339703 0.404639175257732 5.1 5 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.495962698148711 0.631830724678259 0.609016999260902 0.404040404040404 5.1 5 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.579936251277596 0.716362227055572 0.602926829268293 0.4 5.1 5 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.579936251277596 0.716362227055572 0.602926829268293 0.4 5.1 5 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.593188487821762 0.728306486773397 0.602926829268293 0.4 5.1 5 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.593188487821762 0.728306486773397 0.602926829268293 0.4 5.1 5 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.593188487821762 0.728306486773397 0.602926829268293 0.4 5.1 5 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.593188487821762 0.728306486773397 0.602926829268293 0.4 5.1 5 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.593188487821762 0.728306486773397 0.602926829268293 0.4 5.1 5 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.556055659703301 0.691063060050478 0.597369899966281 0.3963133640553 5.1 5 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.588300167319135 0.725434261780875 0.593791574279379 0.393939393939394 5.1 5 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.58244646280626 0.718838956264795 0.593042782886845 0.39344262295082 5.1 5 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.607269198656429 0.744951784213878 0.589819724284199 0.391304347826087 5.1 5 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.714487520915942 0.841652104522671 0.573808203991131 0.380681818181818 5.1 5 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.667895799966983 0.793335328341416 0.565243902439024 0.375 5.1 5 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.667721707619852 0.793335328341416 0.565243902439024 0.375 5.1 5 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.671912558467626 0.797440842951986 0.565243902439024 0.375 5.1 5 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.686966120163586 0.811920921090351 0.558265582655827 0.37037037037037 5.1 5 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.688303812234901 0.812826825568683 0.555327342747112 0.368421052631579 5.1 5 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.717765047286132 0.842722493637101 0.538327526132404 0.357142857142857 5.1 5 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.717765047286132 0.842722493637101 0.538327526132404 0.357142857142857 5.1 5 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.717765047286132 0.842722493637101 0.538327526132404 0.357142857142857 5.1 5 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.717765047286132 0.842722493637101 0.538327526132404 0.357142857142857 5.1 5 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.737181786293487 0.863382454235088 0.538327526132404 0.357142857142857 5.1 5 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.821383356140346 0.92985562115172 0.534238962642791 0.354430379746835 5.1 5 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.732894213002941 0.859067928421076 0.531994261119082 0.352941176470588 5.1 5 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.732894213002941 0.859067928421076 0.531994261119082 0.352941176470588 5.1 5 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.746655575827295 0.873758950988685 0.527560975609756 0.35 5.1 5 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.812177387018024 0.921633510148843 0.522946739671478 0.346938775510204 5.1 5 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.818065248892249 0.927575178624438 0.514693634741226 0.341463414634146 5.1 5 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.780053327018317 0.889658682090189 0.502439024390244 0.333333333333333 5.1 5 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.780053327018317 0.889658682090189 0.502439024390244 0.333333333333333 5.1 5 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.796766278895479 0.90486705097228 0.502439024390244 0.333333333333333 5.1 5 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.82044115589285 0.929528475187521 0.502439024390244 0.333333333333333 5.1 5 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.859229092661681 0.96731249909618 0.502439024390244 0.333333333333333 5.1 5 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.917852218956832 1 0.496079036739735 0.329113924050633 5.1 5 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.898541549940864 0.988882154343272 0.481058640373638 0.319148936170213 5.1 5 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.83111315401762 0.937142645140312 0.471036585365854 0.3125 5.1 5 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.905525307414625 0.995028967143638 0.456762749445676 0.303030303030303 5.1 5 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.945423202509384 1 0.4550391164289 0.30188679245283 5.1 5 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.903907918673418 0.994019295419068 0.452195121951219 0.3 5.1 5 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.95364166642245 1 0.425140712945591 0.282051282051282 5.1 5 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.985381796509809 1 0.424596358639643 0.28169014084507 5.1 5 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.924861421954492 1 0.422048780487805 0.28 5.1 5 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.406254223751306 0.269521410579345 5.1 5 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.92906966108213 1 0.396662387676508 0.263157894736842 5.1 5 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.966108674144096 1 0.388985051140834 0.258064516129032 5.1 5 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.966108674144096 1 0.388985051140834 0.258064516129032 5.1 5 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.966108674144096 1 0.388985051140834 0.258064516129032 5.1 5 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.966108674144096 1 0.388985051140834 0.258064516129032 5.1 5 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.947999337020282 1 0.376829268292683 0.25 5.1 5 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.989763766155277 1 0.376829268292683 0.25 5.1 5 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999997916225867 1 0.364673485444532 0.241935483870968 5.1 5 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.361156441582499 0.239602169981917 5.1 5 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.994451830942369 1 0.352776336274001 0.234042553191489 5.1 5 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.982310342805704 1 0.351707317073171 0.233333333333333 5.1 5 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.989490546912421 1 0.344529616724739 0.228571428571429 5.1 5 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.988523196585075 1 0.322996515679442 0.214285714285714 5.1 5 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.995895463705908 1 0.317329910141207 0.210526315789474 5.1 5 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.995075878201311 1 0.310329985652798 0.205882352941176 5.1 5 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999987579124 1 0.237262872628726 0.157407407407407 5.1 5 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999992919977 1 0.200975609756098 0.133333333333333 5.1 5 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0583477576711251 0.0387096774193548 5.1 5 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 4.17564725728027e-09 3.64536567307351e-08 0.991078765113276 1 5.4 5 4 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 6.48047419281694e-05 0.000234649230951107 0.991078765113276 1 5.4 5 4 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 6.48047419281694e-05 0.000234649230951107 0.991078765113276 1 5.4 5 4 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 6.48047419281694e-05 0.000234649230951107 0.991078765113276 1 5.4 5 4 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 6.48047419281694e-05 0.000234649230951107 0.991078765113276 1 5.4 5 4 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 6.48047419281694e-05 0.000234649230951107 0.991078765113276 1 5.4 5 4 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 6.48047419281694e-05 0.000234649230951107 0.991078765113276 1 5.4 5 4 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.00805590658260988 0.017663413046308 0.991078765113276 1 5.4 5 4 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.30354258135606e-08 2.35580805541771e-07 0.991078765113276 1 5.4 5 4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.31145603035515e-07 8.52147000545834e-07 0.991078765113276 1 5.4 5 4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 2.06608810959472e-06 1.04627878290153e-05 0.991078765113276 1 5.4 5 4 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 3.25342355230066e-05 0.000129319042316308 0.991078765113276 1 5.4 5 4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 3.25342355230066e-05 0.000129319042316308 0.991078765113276 1 5.4 5 4 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000129080387872314 0.000443674859764017 0.991078765113276 1 5.4 5 4 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000129080387872314 0.000443674859764017 0.991078765113276 1 5.4 5 4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.000257099384090563 0.000839111063213007 0.991078765113276 1 5.4 5 4 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000257099384090563 0.000839111063213007 0.991078765113276 1 5.4 5 4 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.000257099384090563 0.000839111063213007 0.991078765113276 1 5.4 5 4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000257099384090563 0.000839111063213007 0.991078765113276 1 5.4 5 4 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000257099384090563 0.000839111063213007 0.991078765113276 1 5.4 5 4 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000512069737044885 0.00154891353478372 0.991078765113276 1 5.4 5 4 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.000512069737044885 0.00154891353478372 0.991078765113276 1 5.4 5 4 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000512069737044885 0.00154891353478372 0.991078765113276 1 5.4 5 4 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00101986921905921 0.00287951170381201 0.991078765113276 1 5.4 5 4 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00101986921905921 0.00287951170381201 0.991078765113276 1 5.4 5 4 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00101986921905921 0.00287951170381201 0.991078765113276 1 5.4 5 4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00101986921905921 0.00287951170381201 0.991078765113276 1 5.4 5 4 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00101986921905921 0.00287951170381201 0.991078765113276 1 5.4 5 4 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0160427571318085 0.0323560835194541 0.991078765113276 1 5.4 5 4 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%REACT_215995.1 NOSTRIN MEDIATED ENOS TRAFFICKING 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605564 MUSCARINIC ACETYLCHOLINE RECEPTORS 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 G2 PHASE%REACTOME%REACT_227891.1 G2 PHASE 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0319470603624618 0.0595034907012868 0.991078765113276 1 5.4 5 4 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 8.1991746016687e-06 3.69222324625777e-05 0.991078765113276 1 5.4 5 4 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 8.1991746016687e-06 3.69222324625777e-05 0.991078765113276 1 5.4 5 4 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00203117414788849 0.00517059179328322 0.991078765113276 1 5.4 5 4 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.00404517336463805 0.00965819076825494 0.991078765113276 1 5.4 5 4 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00404517336463805 0.00965819076825494 0.991078765113276 1 5.4 5 4 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00404517336463805 0.00965819076825494 0.991078765113276 1 5.4 5 4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00404517336463805 0.00965819076825494 0.991078765113276 1 5.4 5 4 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00404517336463805 0.00965819076825494 0.991078765113276 1 5.4 5 4 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00404517336463805 0.00965819076825494 0.991078765113276 1 5.4 5 4 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.00404517336463805 0.00965819076825494 0.991078765113276 1 5.4 5 4 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00404517336463805 0.00965819076825494 0.991078765113276 1 5.4 5 4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 6.1673524036236e-10 7.0775342502874e-09 0.963548799415685 0.972222222222222 5.4 5 4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 6.24208510695346e-08 4.22975576533085e-07 0.956903635281784 0.96551724137931 5.4 5 4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.3131318366196e-07 1.41243062293022e-06 0.954372144183155 0.962962962962963 5.4 5 4 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.63358113637456e-06 8.45303984385817e-06 0.94978381656689 0.958333333333333 5.4 5 4 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 5.96540126690648e-06 2.73831161380901e-05 0.9460297303354 0.954545454545455 5.4 5 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 1.13676826804206e-05 4.93177208970687e-05 0.94388453820312 0.952380952380952 5.4 5 4 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.13676826804206e-05 4.93177208970687e-05 0.94388453820312 0.952380952380952 5.4 5 4 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.13676826804206e-05 4.93177208970687e-05 0.94388453820312 0.952380952380952 5.4 5 4 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 2.16169305385495e-05 8.83933682653905e-05 0.941524826857612 0.95 5.4 5 4 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 4.10126987179208e-05 0.000158589864879351 0.938916724844156 0.947368421052632 5.4 5 4 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 4.10126987179208e-05 0.000158589864879351 0.938916724844156 0.947368421052632 5.4 5 4 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 4.10126987179208e-05 0.000158589864879351 0.938916724844156 0.947368421052632 5.4 5 4 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 5.84805655819447e-09 4.98310448042559e-08 0.937506939972018 0.945945945945946 5.4 5 4 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 7.7614677580529e-05 0.000276806231070408 0.936018833718094 0.944444444444444 5.4 5 4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00014647149627387 0.000497443768968298 0.93278001422426 0.941176470588235 5.4 5 4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00014647149627387 0.000497443768968298 0.93278001422426 0.941176470588235 5.4 5 4 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00014647149627387 0.000497443768968298 0.93278001422426 0.941176470588235 5.4 5 4 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00014647149627387 0.000497443768968298 0.93278001422426 0.941176470588235 5.4 5 4 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00014647149627387 0.000497443768968298 0.93278001422426 0.941176470588235 5.4 5 4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 7.36385984749835e-08 4.96624292084841e-07 0.931013385409441 0.939393939393939 5.4 5 4 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00027555515963231 0.000869434572409705 0.929136342293696 0.9375 5.4 5 4 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 4.83141277750865e-07 2.78344145036227e-06 0.925006847439058 0.933333333333333 5.4 5 4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.83141277750865e-07 2.78344145036227e-06 0.925006847439058 0.933333333333333 5.4 5 4 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000516591831600446 0.00154891353478372 0.925006847439058 0.933333333333333 5.4 5 4 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.000516591831600446 0.00154891353478372 0.925006847439058 0.933333333333333 5.4 5 4 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000516591831600446 0.00154891353478372 0.925006847439058 0.933333333333333 5.4 5 4 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.000516591831600446 0.00154891353478372 0.925006847439058 0.933333333333333 5.4 5 4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 5.04397699889339e-10 5.83543030034577e-09 0.925006847439058 0.933333333333333 5.4 5 4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 9.39988831294961e-10 9.62305112901244e-09 0.923505212946462 0.931818181818182 5.4 5 4 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.98915628010532e-15 1.18261862220622e-13 0.922253850869299 0.930555555555556 5.4 5 4 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 1.74900236338552e-09 1.62668651182849e-08 0.921933734989094 0.930232558139535 5.4 5 4 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.67533432549242e-06 8.60650088511086e-06 0.920287424748042 0.928571428571429 5.4 5 4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 1.67533432549242e-06 8.60650088511086e-06 0.920287424748042 0.928571428571429 5.4 5 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000964663785146198 0.00275093500253114 0.920287424748042 0.928571428571429 5.4 5 4 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000964663785146198 0.00275093500253114 0.920287424748042 0.928571428571429 5.4 5 4 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000964663785146198 0.00275093500253114 0.920287424748042 0.928571428571429 5.4 5 4 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000964663785146198 0.00275093500253114 0.920287424748042 0.928571428571429 5.4 5 4 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 3.24896405638581e-09 2.87159990822175e-08 0.920287424748042 0.928571428571429 5.4 5 4 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 6.02493938020545e-09 5.07307025919074e-08 0.918560806690353 0.926829268292683 5.4 5 4 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 6.02493938020545e-09 5.07307025919074e-08 0.918560806690353 0.926829268292683 5.4 5 4 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 3.10840626804607e-06 1.52002134688301e-05 0.917665523253034 0.925925925925926 5.4 5 4 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 5.75202653483844e-06 2.64891060164243e-05 0.91484193702764 0.923076923076923 5.4 5 4 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 5.75202653483844e-06 2.64891060164243e-05 0.91484193702764 0.923076923076923 5.4 5 4 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 5.75202653483844e-06 2.64891060164243e-05 0.91484193702764 0.923076923076923 5.4 5 4 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00179332733870955 0.00468239413391502 0.91484193702764 0.923076923076923 5.4 5 4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00179332733870955 0.00468239413391502 0.91484193702764 0.923076923076923 5.4 5 4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00179332733870955 0.00468239413391502 0.91484193702764 0.923076923076923 5.4 5 4 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00179332733870955 0.00468239413391502 0.91484193702764 0.923076923076923 5.4 5 4 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00179332733870955 0.00468239413391502 0.91484193702764 0.923076923076923 5.4 5 4 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.06136250232524e-05 4.67166438597498e-05 0.911792463904214 0.92 5.4 5 4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.06136250232524e-05 4.67166438597498e-05 0.911792463904214 0.92 5.4 5 4 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.06136250232524e-05 4.67166438597498e-05 0.911792463904214 0.92 5.4 5 4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 1.95240070746186e-05 8.00653085509574e-05 0.908488868020503 0.916666666666667 5.4 5 4 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 1.95240070746186e-05 8.00653085509574e-05 0.908488868020503 0.916666666666667 5.4 5 4 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00331674361954243 0.00819396904619597 0.908488868020503 0.916666666666667 5.4 5 4 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.28359907721468e-07 8.37872241686466e-07 0.908488868020503 0.916666666666667 5.4 5 4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.28359907721468e-07 8.37872241686466e-07 0.908488868020503 0.916666666666667 5.4 5 4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 3.5795389941528e-05 0.000141099279464804 0.904898002929513 0.91304347826087 5.4 5 4 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 6.97819202465478e-11 9.73526201086642e-10 0.902589589656734 0.910714285714286 5.4 5 4 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 7.83004535178615e-07 4.31866454867895e-06 0.900980695557524 0.909090909090909 5.4 5 4 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 6.53904968155622e-05 0.000234976456991275 0.900980695557524 0.909090909090909 5.4 5 4 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 6.53904968155622e-05 0.000234976456991275 0.900980695557524 0.909090909090909 5.4 5 4 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 6.53904968155622e-05 0.000234976456991275 0.900980695557524 0.909090909090909 5.4 5 4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.00609786403920246 0.0139955814964276 0.900980695557524 0.909090909090909 5.4 5 4 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000118984785190774 0.000411959487412339 0.896690311292964 0.904761904761905 5.4 5 4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000118984785190774 0.000411959487412339 0.896690311292964 0.904761904761905 5.4 5 4 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 7.56434182843847e-10 8.54786347709632e-09 0.89578273000623 0.903846153846154 5.4 5 4 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 2.5789233288772e-06 1.28765189368149e-05 0.895167916876508 0.903225806451613 5.4 5 4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.30325004216539e-13 7.85067283333506e-12 0.894723885171708 0.902777777777778 5.4 5 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.36616339900969e-09 1.30473189046362e-08 0.893914180298249 0.901960784313726 5.4 5 4 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.36616339900969e-09 1.30473189046362e-08 0.893914180298249 0.901960784313726 5.4 5 4 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 4.88547325787724e-19 2.39725118826183e-17 0.891970888601949 0.9 5.4 5 4 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000215574612332264 0.000711746341876593 0.891970888601949 0.9 5.4 5 4 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000215574612332264 0.000711746341876593 0.891970888601949 0.9 5.4 5 4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000215574612332264 0.000711746341876593 0.891970888601949 0.9 5.4 5 4 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000215574612332264 0.000711746341876593 0.891970888601949 0.9 5.4 5 4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000215574612332264 0.000711746341876593 0.891970888601949 0.9 5.4 5 4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.011132918507352 0.0235395884635392 0.891970888601949 0.9 5.4 5 4 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 4.42903541702429e-09 3.84299841367413e-08 0.889948278877228 0.897959183673469 5.4 5 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 8.38865234573698e-06 3.74202266080994e-05 0.888553375618799 0.896551724137931 5.4 5 4 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 8.38865234573698e-06 3.74202266080994e-05 0.888553375618799 0.896551724137931 5.4 5 4 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 7.94898445575731e-09 6.5383843240131e-08 0.88784139374731 0.895833333333333 5.4 5 4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000388731497912698 0.00120778367146238 0.886754684575037 0.894736842105263 5.4 5 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 1.50506724559932e-05 6.26231196049075e-05 0.884891754565425 0.892857142857143 5.4 5 4 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 1.50506724559932e-05 6.26231196049075e-05 0.884891754565425 0.892857142857143 5.4 5 4 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 1.50506724559932e-05 6.26231196049075e-05 0.884891754565425 0.892857142857143 5.4 5 4 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.20348001948853e-35 2.14069008466522e-33 0.884415579630233 0.89237668161435 5.4 5 4 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.58620138360426e-11 3.91506869028603e-10 0.884347205793385 0.892307692307692 5.4 5 4 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.58620138360426e-11 3.91506869028603e-10 0.884347205793385 0.892307692307692 5.4 5 4 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.61181949795272e-11 6.56261914558672e-10 0.882679525179011 0.890625 5.4 5 4 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.65034105211243e-16 6.0216290183487e-15 0.882060100950816 0.89 5.4 5 4 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.69009886691772e-05 0.000107528390101796 0.880958902322912 0.888888888888889 5.4 5 4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 2.69009886691772e-05 0.000107528390101796 0.880958902322912 0.888888888888889 5.4 5 4 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.08922850902773e-06 5.76197832099054e-06 0.880958902322912 0.888888888888889 5.4 5 4 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.08922850902773e-06 5.76197832099054e-06 0.880958902322912 0.888888888888889 5.4 5 4 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000697326045820602 0.00206298329148174 0.880958902322912 0.888888888888889 5.4 5 4 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000697326045820602 0.00206298329148174 0.880958902322912 0.888888888888889 5.4 5 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000697326045820602 0.00206298329148174 0.880958902322912 0.888888888888889 5.4 5 4 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0201571670986346 0.0394006164579079 0.880958902322912 0.888888888888889 5.4 5 4 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0201571670986346 0.0394006164579079 0.880958902322912 0.888888888888889 5.4 5 4 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0201571670986346 0.0394006164579079 0.880958902322912 0.888888888888889 5.4 5 4 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0201571670986346 0.0394006164579079 0.880958902322912 0.888888888888889 5.4 5 4 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0201571670986346 0.0394006164579079 0.880958902322912 0.888888888888889 5.4 5 4 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.975389911354e-25 2.64623740241046e-23 0.879582404038033 0.8875 5.4 5 4 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 4.78858801010928e-05 0.000182685274487547 0.876723522984821 0.884615384615385 5.4 5 4 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 4.78858801010928e-05 0.000182685274487547 0.876723522984821 0.884615384615385 5.4 5 4 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.78858801010928e-05 0.000182685274487547 0.876723522984821 0.884615384615385 5.4 5 4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 4.78858801010928e-05 0.000182685274487547 0.876723522984821 0.884615384615385 5.4 5 4 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.42772374345975e-07 9.19299043865713e-07 0.875837048239639 0.883720930232558 5.4 5 4 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 4.57591210887899e-10 5.33731387781541e-09 0.875452909183394 0.883333333333333 5.4 5 4 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 4.57591210887899e-10 5.33731387781541e-09 0.875452909183394 0.883333333333333 5.4 5 4 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 4.57591210887899e-10 5.33731387781541e-09 0.875452909183394 0.883333333333333 5.4 5 4 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 4.57591210887899e-10 5.33731387781541e-09 0.875452909183394 0.883333333333333 5.4 5 4 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 4.57591210887899e-10 5.33731387781541e-09 0.875452909183394 0.883333333333333 5.4 5 4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 4.57591210887899e-10 5.33731387781541e-09 0.875452909183394 0.883333333333333 5.4 5 4 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 4.57591210887899e-10 5.33731387781541e-09 0.875452909183394 0.883333333333333 5.4 5 4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 3.43331548263532e-06 1.66177140537077e-05 0.874481263335244 0.882352941176471 5.4 5 4 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 3.43331548263532e-06 1.66177140537077e-05 0.874481263335244 0.882352941176471 5.4 5 4 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0012436826348206 0.00344311359795663 0.874481263335244 0.882352941176471 5.4 5 4 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0012436826348206 0.00344311359795663 0.874481263335244 0.882352941176471 5.4 5 4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0012436826348206 0.00344311359795663 0.874481263335244 0.882352941176471 5.4 5 4 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0012436826348206 0.00344311359795663 0.874481263335244 0.882352941176471 5.4 5 4 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.88509550320313e-08 1.3898916585793e-07 0.872149313299683 0.88 5.4 5 4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 8.48668087846365e-05 0.000298924427971628 0.872149313299683 0.88 5.4 5 4 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 8.48668087846365e-05 0.000298924427971628 0.872149313299683 0.88 5.4 5 4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 8.48668087846365e-05 0.000298924427971628 0.872149313299683 0.88 5.4 5 4 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 6.06383752478733e-06 2.77454688031266e-05 0.870948005705606 0.878787878787879 5.4 5 4 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 3.31752859000109e-08 2.35580805541771e-07 0.869722181630018 0.877551020408163 5.4 5 4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000149695070009895 0.000507181153866858 0.867193919474117 0.875 5.4 5 4 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.96469330246621e-12 3.36838381856556e-11 0.867193919474117 0.875 5.4 5 4 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 7.81436426694117e-07 4.31866454867895e-06 0.867193919474117 0.875 5.4 5 4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.06696481057053e-05 4.67166438597498e-05 0.867193919474117 0.875 5.4 5 4 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 1.06696481057053e-05 4.67166438597498e-05 0.867193919474117 0.875 5.4 5 4 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 1.06696481057053e-05 4.67166438597498e-05 0.867193919474117 0.875 5.4 5 4 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00220384853537741 0.0055901541280607 0.867193919474117 0.875 5.4 5 4 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0361310391084127 0.0654128099888947 0.867193919474117 0.875 5.4 5 4 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.01921945494391e-07 6.74581062504734e-07 0.86455807169456 0.872340425531915 5.4 5 4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.01921945494391e-07 6.74581062504734e-07 0.86455807169456 0.872340425531915 5.4 5 4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.01921945494391e-07 6.74581062504734e-07 0.86455807169456 0.872340425531915 5.4 5 4 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 1.36844586978852e-06 7.18560322032863e-06 0.864017384970548 0.871794871794872 5.4 5 4 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 1.36844586978852e-06 7.18560322032863e-06 0.864017384970548 0.871794871794872 5.4 5 4 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 7.80315925763494e-11 1.07804811879753e-09 0.863654352455855 0.871428571428571 5.4 5 4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.86990182592773e-05 7.71266753129031e-05 0.863197634130918 0.870967741935484 5.4 5 4 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 8.07496158495176e-13 1.45451523232739e-11 0.86282151315744 0.870588235294118 5.4 5 4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.77884633068573e-07 1.12254373356028e-06 0.861807621837631 0.869565217391304 5.4 5 4 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.77884633068573e-07 1.12254373356028e-06 0.861807621837631 0.869565217391304 5.4 5 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000262691209309122 0.000853446554444934 0.861807621837631 0.869565217391304 5.4 5 4 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 3.09527360371618e-07 1.85066148659165e-06 0.858934929764839 0.866666666666667 5.4 5 4 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00387713148319358 0.00949596919205587 0.858934929764839 0.866666666666667 5.4 5 4 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00387713148319358 0.00949596919205587 0.858934929764839 0.866666666666667 5.4 5 4 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00387713148319358 0.00949596919205587 0.858934929764839 0.866666666666667 5.4 5 4 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.10141898088991e-10 5.18748460449814e-09 0.857948781739851 0.865671641791045 5.4 5 4 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 5.36896032755536e-07 3.08065747827068e-06 0.855931660779648 0.863636363636364 5.4 5 4 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000458415278233782 0.00140890915966884 0.855931660779648 0.863636363636364 5.4 5 4 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000458415278233782 0.00140890915966884 0.855931660779648 0.863636363636364 5.4 5 4 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000458415278233782 0.00140890915966884 0.855931660779648 0.863636363636364 5.4 5 4 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 5.66882981450949e-05 0.000214818139499907 0.854378245787307 0.862068965517241 5.4 5 4 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 5.66882981450949e-05 0.000214818139499907 0.854378245787307 0.862068965517241 5.4 5 4 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.35037338862281e-28 3.40541523715019e-26 0.854215507073824 0.861904761904762 5.4 5 4 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.98076589664215e-18 2.7453644744909e-16 0.85385247455913 0.861538461538462 5.4 5 4 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 7.60956762604768e-17 2.92659857617996e-15 0.852977625712246 0.860655737704918 5.4 5 4 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 9.28214623071008e-07 5.04140995660322e-06 0.852788704864912 0.86046511627907 5.4 5 4 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 8.9135811241611e-36 1.81200370566875e-33 0.852619231751862 0.860294117647059 5.4 5 4 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 3.76105572262557e-11 5.4612064217308e-10 0.851311246956276 0.858974358974359 5.4 5 4 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00676530866008962 0.0152810067036627 0.849496084382808 0.857142857142857 5.4 5 4 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.00676530866008962 0.0152810067036627 0.849496084382808 0.857142857142857 5.4 5 4 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.00676530866008962 0.0152810067036627 0.849496084382808 0.857142857142857 5.4 5 4 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00676530866008962 0.0152810067036627 0.849496084382808 0.857142857142857 5.4 5 4 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00676530866008962 0.0152810067036627 0.849496084382808 0.857142857142857 5.4 5 4 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.063963860427 0.105104588207415 0.849496084382808 0.857142857142857 5.4 5 4 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.63296773124237e-09 3.19118091454191e-08 0.849496084382808 0.857142857142857 5.4 5 4 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000795113575181203 0.00231379676376861 0.849496084382808 0.857142857142857 5.4 5 4 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000795113575181203 0.00231379676376861 0.849496084382808 0.857142857142857 5.4 5 4 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.000795113575181203 0.00231379676376861 0.849496084382808 0.857142857142857 5.4 5 4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 1.2410870396231e-05 5.36798436894735e-05 0.849496084382808 0.857142857142857 5.4 5 4 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 2.68670902712127e-13 6.70734551858521e-12 0.848036469117546 0.855670103092783 5.4 5 4 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 8.28956542402876e-10 8.54786347709632e-09 0.847444161473671 0.855072463768116 5.4 5 4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.22349777226066e-22 1.66528280522469e-20 0.84702661902123 0.854651162790698 5.4 5 4 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 3.57835341768896e-07 2.12166538057141e-06 0.846546445200923 0.854166666666667 5.4 5 4 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.74529519393471e-06 1.36592834299619e-05 0.846042848267431 0.853658536585366 5.4 5 4 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.04764114757359e-23 1.71399608999836e-21 0.844854029276891 0.852459016393443 5.4 5 4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 8.04788503651139e-08 5.40195302214892e-07 0.844252281392791 0.851851851851852 5.4 5 4 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000168549005834607 0.00056567272477039 0.844252281392791 0.851851851851852 5.4 5 4 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000168549005834607 0.00056567272477039 0.844252281392791 0.851851851851852 5.4 5 4 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 7.63772554592103e-16 2.48711221038759e-14 0.843645560385681 0.851239669421488 5.4 5 4 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 7.63772554592103e-16 2.48711221038759e-14 0.843645560385681 0.851239669421488 5.4 5 4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.41941039677293e-09 2.20693653500505e-08 0.843156561365026 0.850746268656716 5.4 5 4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.41941039677293e-09 2.20693653500505e-08 0.843156561365026 0.850746268656716 5.4 5 4 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.16291253553262e-14 1.11770274303074e-12 0.842880071264562 0.850467289719626 5.4 5 4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.07813097802639e-13 7.55203514091648e-12 0.842416950346285 0.85 5.4 5 4 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00136995384953516 0.00369913534703706 0.842416950346285 0.85 5.4 5 4 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 4.02455666332931e-20 2.7271162532941e-18 0.841481970379197 0.849056603773585 5.4 5 4 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 1.37224947099345e-07 8.87595907828945e-07 0.841481970379197 0.849056603773585 5.4 5 4 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 9.41180789083518e-18 4.18531332145577e-16 0.841347440887529 0.848920863309353 5.4 5 4 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.95785076040124e-19 1.61885447386576e-17 0.841112899339557 0.848684210526316 5.4 5 4 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 3.64621873588458e-05 0.000143330642573585 0.840915315853689 0.848484848484849 5.4 5 4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 2.08673466665265e-30 2.69947584604247e-28 0.839829796943379 0.847389558232932 5.4 5 4 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.15995123706679e-19 6.87754420977518e-18 0.839576278726533 0.847133757961783 5.4 5 4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 2.86969608735809e-11 4.20987374465007e-10 0.839502012801834 0.847058823529412 5.4 5 4 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 2.86969608735809e-11 4.20987374465007e-10 0.839502012801834 0.847058823529412 5.4 5 4 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 8.87961505515995e-13 1.57946152793658e-11 0.839383035759203 0.846938775510204 5.4 5 4 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.33254530139566e-07 1.41243062293022e-06 0.838605108942003 0.846153846153846 5.4 5 4 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.33254530139566e-07 1.41243062293022e-06 0.838605108942003 0.846153846153846 5.4 5 4 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000288261916544128 0.000903516976304611 0.838605108942003 0.846153846153846 5.4 5 4 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0116955331641233 0.0244386838363399 0.838605108942003 0.846153846153846 5.4 5 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0116955331641233 0.0244386838363399 0.838605108942003 0.846153846153846 5.4 5 4 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0116955331641233 0.0244386838363399 0.838605108942003 0.846153846153846 5.4 5 4 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0116955331641233 0.0244386838363399 0.838605108942003 0.846153846153846 5.4 5 4 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0116955331641233 0.0244386838363399 0.838605108942003 0.846153846153846 5.4 5 4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0116955331641233 0.0244386838363399 0.838605108942003 0.846153846153846 5.4 5 4 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0116955331641233 0.0244386838363399 0.838605108942003 0.846153846153846 5.4 5 4 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0116955331641233 0.0244386838363399 0.838605108942003 0.846153846153846 5.4 5 4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.37070679823739e-16 1.16988189607117e-14 0.837423142615094 0.844961240310077 5.4 5 4 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 5.24400175346653e-08 3.58760312268407e-07 0.837290680871561 0.844827586206897 5.4 5 4 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 5.24400175346653e-08 3.58760312268407e-07 0.837290680871561 0.844827586206897 5.4 5 4 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 7.91748860433887e-14 2.08640486740263e-12 0.836506847618545 0.844036697247706 5.4 5 4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.35637934955393e-05 5.83120185623941e-05 0.834592644305917 0.842105263157895 5.4 5 4 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00234316363466275 0.00593295703225105 0.834592644305917 0.842105263157895 5.4 5 4 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.38703382269776e-10 1.86202748084803e-09 0.83395652186361 0.841463414634146 5.4 5 4 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.99661288616711e-06 1.47040694379855e-05 0.83340714339071 0.840909090909091 5.4 5 4 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.99661288616711e-06 1.47040694379855e-05 0.83340714339071 0.840909090909091 5.4 5 4 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 6.67333738294301e-07 3.73864531335744e-06 0.832506162695152 0.84 5.4 5 4 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000490043441442505 0.0014996383165004 0.832506162695152 0.84 5.4 5 4 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000490043441442505 0.0014996383165004 0.832506162695152 0.84 5.4 5 4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.02643205466164e-09 1.00041973546816e-08 0.832506162695152 0.84 5.4 5 4 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.02643205466164e-09 1.00041973546816e-08 0.832506162695152 0.84 5.4 5 4 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.02643205466164e-09 1.00041973546816e-08 0.832506162695152 0.84 5.4 5 4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.02643205466164e-09 1.00041973546816e-08 0.832506162695152 0.84 5.4 5 4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.02643205466164e-09 1.00041973546816e-08 0.832506162695152 0.84 5.4 5 4 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 7.35522439562548e-43 1.74441405249584e-40 0.832082171779595 0.839572192513369 5.4 5 4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 3.36653065369242e-08 2.35580805541771e-07 0.831227351385328 0.838709677419355 5.4 5 4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.000105082335336697 0.00036650039996108 0.831227351385328 0.838709677419355 5.4 5 4 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.77982921170089e-12 4.70916305744091e-11 0.830904419236383 0.838383838383838 5.4 5 4 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 7.60909767904846e-09 6.29520116121276e-08 0.830757200168481 0.838235294117647 5.4 5 4 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.29045528812615e-05 9.2331951133244e-05 0.830363289689502 0.837837837837838 5.4 5 4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.29045528812615e-05 9.2331951133244e-05 0.830363289689502 0.837837837837838 5.4 5 4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 2.29045528812615e-05 9.2331951133244e-05 0.830363289689502 0.837837837837838 5.4 5 4 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 8.93546765806628e-11 1.22261254590657e-09 0.829740361490185 0.837209302325581 5.4 5 4 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 5.05004743991364e-06 2.37168894620367e-05 0.829740361490185 0.837209302325581 5.4 5 4 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.56324822422647e-16 5.85395321861648e-15 0.828258682273238 0.835714285714286 5.4 5 4 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.8927069329432e-09 2.60526706682163e-08 0.828161707834381 0.835616438356164 5.4 5 4 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.49672763420404e-10 1.95398479217647e-09 0.827842262624031 0.835294117647059 5.4 5 4 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.49672763420404e-10 1.95398479217647e-09 0.827842262624031 0.835294117647059 5.4 5 4 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.49672763420404e-10 1.95398479217647e-09 0.827842262624031 0.835294117647059 5.4 5 4 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.74108272181967e-29 3.00043131780722e-27 0.827169584729157 0.834615384615385 5.4 5 4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.61359957480951e-16 9.29788048738483e-15 0.827087314770792 0.834532374100719 5.4 5 4 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00082767190580526 0.0023793477211331 0.82589897092773 0.833333333333333 5.4 5 4 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00082767190580526 0.0023793477211331 0.82589897092773 0.833333333333333 5.4 5 4 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00082767190580526 0.0023793477211331 0.82589897092773 0.833333333333333 5.4 5 4 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00082767190580526 0.0023793477211331 0.82589897092773 0.833333333333333 5.4 5 4 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00082767190580526 0.0023793477211331 0.82589897092773 0.833333333333333 5.4 5 4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0200034661375026 0.0393705841129547 0.82589897092773 0.833333333333333 5.4 5 4 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0200034661375026 0.0393705841129547 0.82589897092773 0.833333333333333 5.4 5 4 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0200034661375026 0.0393705841129547 0.82589897092773 0.833333333333333 5.4 5 4 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_217410.1 ACTIVATION OF TRKA RECEPTORS 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604744 PYRIMIDINE BIOSYNTHESIS 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.111468576515728 0.172225607363606 0.82589897092773 0.833333333333333 5.4 5 4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 3.84972782639475e-05 0.000150086649231773 0.82589897092773 0.833333333333333 5.4 5 4 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000176970732189166 0.00059203831781993 0.82589897092773 0.833333333333333 5.4 5 4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0039754655798206 0.00962089714300121 0.82589897092773 0.833333333333333 5.4 5 4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0039754655798206 0.00962089714300121 0.82589897092773 0.833333333333333 5.4 5 4 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0039754655798206 0.00962089714300121 0.82589897092773 0.833333333333333 5.4 5 4 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0039754655798206 0.00962089714300121 0.82589897092773 0.833333333333333 5.4 5 4 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0039754655798206 0.00962089714300121 0.82589897092773 0.833333333333333 5.4 5 4 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0039754655798206 0.00962089714300121 0.82589897092773 0.833333333333333 5.4 5 4 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0039754655798206 0.00962089714300121 0.82589897092773 0.833333333333333 5.4 5 4 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.57907421346812e-07 1.00763345550006e-06 0.823099313399162 0.830508474576271 5.4 5 4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.57907421346812e-07 1.00763345550006e-06 0.823099313399162 0.830508474576271 5.4 5 4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.41640149542589e-05 5.94554374038657e-05 0.82187019545979 0.829268292682927 5.4 5 4 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 1.41640149542589e-05 5.94554374038657e-05 0.82187019545979 0.829268292682927 5.4 5 4 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.41640149542589e-05 5.94554374038657e-05 0.82187019545979 0.829268292682927 5.4 5 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 1.41640149542589e-05 5.94554374038657e-05 0.82187019545979 0.829268292682927 5.4 5 4 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.41640149542589e-05 5.94554374038657e-05 0.82187019545979 0.829268292682927 5.4 5 4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.41640149542589e-05 5.94554374038657e-05 0.82187019545979 0.829268292682927 5.4 5 4 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.69029776929401e-16 2.48711221038759e-14 0.821179548236714 0.828571428571429 5.4 5 4 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 6.43858410722874e-05 0.000234649230951107 0.821179548236714 0.828571428571429 5.4 5 4 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 6.43858410722874e-05 0.000234649230951107 0.821179548236714 0.828571428571429 5.4 5 4 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 6.43858410722874e-05 0.000234649230951107 0.821179548236714 0.828571428571429 5.4 5 4 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.37412969972864e-11 2.17265173634873e-10 0.820893522619077 0.828282828282828 5.4 5 4 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.15171841902887e-09 1.11489476889666e-08 0.81978120077271 0.827160493827161 5.4 5 4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.40663633920895e-14 6.58585290518141e-13 0.819395829424362 0.826771653543307 5.4 5 4 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 5.23021718129293e-06 2.43222191143132e-05 0.81871724074575 0.826086956521739 5.4 5 4 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 5.23021718129293e-06 2.43222191143132e-05 0.81871724074575 0.826086956521739 5.4 5 4 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00138810460562592 0.00373397514897104 0.81871724074575 0.826086956521739 5.4 5 4 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00138810460562592 0.00373397514897104 0.81871724074575 0.826086956521739 5.4 5 4 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 4.3517837446184e-10 5.33731387781541e-09 0.818216189802821 0.825581395348837 5.4 5 4 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.35630344798983e-05 9.47180736296477e-05 0.817639981218453 0.825 5.4 5 4 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.30521679094146e-19 1.70611720251071e-17 0.817499998342024 0.824858757062147 5.4 5 4 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.19870347314405e-44 1.4795510084568e-41 0.816593067029953 0.823943661971831 5.4 5 4 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.88273115802352e-27 1.78608429191165e-25 0.816405879307871 0.823754789272031 5.4 5 4 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.93728205837885e-06 9.8455441752611e-06 0.816182512446228 0.823529411764706 5.4 5 4 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.00668462273797583 0.0152195490498234 0.816182512446227 0.823529411764706 5.4 5 4 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00668462273797583 0.0152195490498234 0.816182512446227 0.823529411764706 5.4 5 4 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 3.14882344455174e-09 2.81809796326863e-08 0.815444553574215 0.822784810126582 5.4 5 4 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.000493061157311706 0.00150241119240805 0.814100414200191 0.821428571428571 5.4 5 4 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000493061157311706 0.00150241119240805 0.814100414200191 0.821428571428571 5.4 5 4 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 9.62001730725684e-30 1.14077371901887e-27 0.8118051318334 0.819112627986348 5.4 5 4 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000177237050872305 0.00059203831781993 0.810882626001772 0.818181818181818 5.4 5 4 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.033790663614025 0.0621241787115731 0.810882626001771 0.818181818181818 5.4 5 4 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.033790663614025 0.0621241787115731 0.810882626001771 0.818181818181818 5.4 5 4 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.033790663614025 0.0621241787115731 0.810882626001771 0.818181818181818 5.4 5 4 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.033790663614025 0.0621241787115731 0.810882626001771 0.818181818181818 5.4 5 4 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.033790663614025 0.0621241787115731 0.810882626001771 0.818181818181818 5.4 5 4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.033790663614025 0.0621241787115731 0.810882626001771 0.818181818181818 5.4 5 4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.033790663614025 0.0621241787115731 0.810882626001771 0.818181818181818 5.4 5 4 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.07615431701635e-17 4.64050785792201e-16 0.810352637357326 0.817647058823529 5.4 5 4 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.75787022358589e-10 3.56768120742066e-09 0.809913829554935 0.817204301075269 5.4 5 4 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.761024262958e-17 7.37040448879185e-16 0.809283251985989 0.816568047337278 5.4 5 4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 9.02535803169417e-12 1.45944141807964e-10 0.809229450413593 0.81651376146789 5.4 5 4 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 7.59510450350887e-17 2.92659857617996e-15 0.808671630429851 0.815950920245399 5.4 5 4 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.22891894181848e-09 4.48238051458295e-08 0.80754566046267 0.814814814814815 5.4 5 4 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.22891894181848e-09 4.48238051458295e-08 0.80754566046267 0.814814814814815 5.4 5 4 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000814998723666011 0.00236682282403415 0.80754566046267 0.814814814814815 5.4 5 4 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.56517762472185e-18 7.42415919993062e-17 0.806943912578569 0.814207650273224 5.4 5 4 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 7.19800548305421e-07 4.00107882905709e-06 0.80630136822775 0.813559322033898 5.4 5 4 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.28037135121022e-08 1.64719209785388e-07 0.806077395625465 0.813333333333333 5.4 5 4 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0111280242570637 0.0235395884635392 0.805251496654537 0.8125 5.4 5 4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0111280242570637 0.0235395884635392 0.805251496654537 0.8125 5.4 5 4 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0111280242570637 0.0235395884635392 0.805251496654537 0.8125 5.4 5 4 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0111280242570637 0.0235395884635392 0.805251496654537 0.8125 5.4 5 4 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.19569905419271e-09 2.84217484632264e-08 0.804522762268424 0.811764705882353 5.4 5 4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.17368934078561e-06 1.54663011367737e-05 0.804082771695677 0.811320754716981 5.4 5 4 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.83450902941526e-13 4.74637517974166e-12 0.803374453538792 0.810606060606061 5.4 5 4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.38807515172454e-08 1.10968030387866e-07 0.802899252749996 0.810126582278481 5.4 5 4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.38807515172454e-08 1.10968030387866e-07 0.802899252749996 0.810126582278481 5.4 5 4 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.38807515172454e-08 1.10968030387866e-07 0.802899252749996 0.810126582278481 5.4 5 4 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.04089219603875e-49 1.44239653165438e-46 0.802660748932045 0.809885931558935 5.4 5 4 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 3.83392776537445e-05 0.000149881296981534 0.802301857472652 0.80952380952381 5.4 5 4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 3.83392776537445e-05 0.000149881296981534 0.802301857472652 0.80952380952381 5.4 5 4 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 5.1642734902019e-06 2.41735565018332e-05 0.800486694899185 0.807692307692308 5.4 5 4 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0013375258460157 0.00367432293220143 0.800486694899185 0.807692307692308 5.4 5 4 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0013375258460157 0.00367432293220143 0.800486694899185 0.807692307692308 5.4 5 4 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0013375258460157 0.00367432293220143 0.800486694899185 0.807692307692308 5.4 5 4 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 5.48714020934165e-12 9.07930292778275e-11 0.799525726477937 0.80672268907563 5.4 5 4 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 7.06476691152844e-07 3.94241698631567e-06 0.799257068639739 0.806451612903226 5.4 5 4 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.62410302991096e-07 1.58224517439123e-06 0.798779900240551 0.805970149253731 5.4 5 4 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.3613048786467e-08 1.10693533846528e-07 0.797697542652149 0.804878048780488 5.4 5 4 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 6.23339900231609e-05 0.000234649230951107 0.797697542652149 0.804878048780488 5.4 5 4 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.27818157372432e-05 9.2331951133244e-05 0.797172050199809 0.804347826086957 5.4 5 4 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 8.368292281956e-06 3.74202266080994e-05 0.796749595483222 0.803921568627451 5.4 5 4 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.79413963468952e-20 2.96611334789704e-18 0.792863012090621 0.8 5.4 5 4 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.35708233803935e-19 1.70611720251071e-17 0.792863012090621 0.8 5.4 5 4 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 4.97514161224433e-06 2.35203538678528e-05 0.792863012090621 0.8 5.4 5 4 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00217818576325627 0.00553492560913156 0.792863012090621 0.8 5.4 5 4 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.66989207148082e-15 1.61365128354344e-13 0.792863012090621 0.8 5.4 5 4 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000100813126072742 0.000352474394106909 0.792863012090621 0.8 5.4 5 4 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000100813126072742 0.000352474394106909 0.792863012090621 0.8 5.4 5 4 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000773681608261215 0.00226999779083651 0.792863012090621 0.8 5.4 5 4 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.000773681608261215 0.00226999779083651 0.792863012090621 0.8 5.4 5 4 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00623600277517314 0.0142666108505971 0.792863012090621 0.8 5.4 5 4 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00623600277517314 0.0142666108505971 0.792863012090621 0.8 5.4 5 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0183180173676738 0.0363043714682448 0.792863012090621 0.8 5.4 5 4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0183180173676738 0.0363043714682448 0.792863012090621 0.8 5.4 5 4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0183180173676738 0.0363043714682448 0.792863012090621 0.8 5.4 5 4 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0183180173676738 0.0363043714682448 0.792863012090621 0.8 5.4 5 4 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0183180173676738 0.0363043714682448 0.792863012090621 0.8 5.4 5 4 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0562541614637647 0.097837027458843 0.792863012090621 0.8 5.4 5 4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000278065085595201 0.000873480390291326 0.792863012090621 0.8 5.4 5 4 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.000278065085595201 0.000873480390291326 0.792863012090621 0.8 5.4 5 4 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 5.90210894913039e-11 8.3155455788243e-10 0.791124277414984 0.798245614035088 5.4 5 4 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.64454267260987e-20 2.96611334789704e-18 0.79108529233257 0.798206278026906 5.4 5 4 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 5.65454604455307e-08 3.84996125425791e-07 0.790353951925777 0.79746835443038 5.4 5 4 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.06793190811552e-07 2.38216753302402e-06 0.789990320017829 0.797101449275362 5.4 5 4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.06793190811552e-07 2.38216753302402e-06 0.789990320017829 0.797101449275362 5.4 5 4 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.33669947980048e-11 2.13721725815291e-10 0.789639991716269 0.796747967479675 5.4 5 4 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.0337018855976e-12 1.31401813600062e-10 0.788180750208196 0.795275590551181 5.4 5 4 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 3.37726523756299e-08 2.35580805541771e-07 0.788086728885256 0.795180722891566 5.4 5 4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 3.37726523756299e-08 2.35580805541771e-07 0.788086728885256 0.795180722891566 5.4 5 4 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000447682014326127 0.00138791177861891 0.787033137001719 0.794117647058823 5.4 5 4 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.74903767101199e-06 8.92071901738375e-06 0.7865704485026 0.793650793650794 5.4 5 4 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.74903767101199e-06 8.92071901738375e-06 0.7865704485026 0.793650793650794 5.4 5 4 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 2.01435070506103e-08 1.46245972107237e-07 0.786027986124322 0.793103448275862 5.4 5 4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 2.01435070506103e-08 1.46245972107237e-07 0.786027986124322 0.793103448275862 5.4 5 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00124726278195953 0.00344632026937557 0.786027986124322 0.793103448275862 5.4 5 4 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 1.27646856970639e-05 5.50428719603695e-05 0.785383172353917 0.792452830188679 5.4 5 4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 3.85642844948955e-07 2.27705298075669e-06 0.784604022381344 0.791666666666667 5.4 5 4 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 3.46615983453228e-05 0.000137009595681651 0.784604022381344 0.791666666666667 5.4 5 4 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00351774886494441 0.00866047860694791 0.784604022381344 0.791666666666667 5.4 5 4 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.00948762458502e-09 1.00041973546816e-08 0.78342416670859 0.79047619047619 5.4 5 4 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 2.78448009923986e-06 1.37580388236747e-05 0.783271927266944 0.790322580645161 5.4 5 4 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.28558117051996e-07 1.40188879553875e-06 0.782430604036797 0.789473684210526 5.4 5 4 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0100965978741625 0.0219350515647836 0.782430604036797 0.789473684210526 5.4 5 4 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0100965978741625 0.0219350515647836 0.782430604036797 0.789473684210526 5.4 5 4 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.90223113239924e-08 1.39529634092995e-07 0.781851025811584 0.788888888888889 5.4 5 4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 6.12117059101247e-07 3.44285602806749e-06 0.781695927413288 0.788732394366197 5.4 5 4 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.59816632885817e-09 1.49617808287183e-08 0.781427487877775 0.788461538461538 5.4 5 4 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.000716012636130562 0.00210949478512172 0.780849936149854 0.787878787878788 5.4 5 4 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.000716012636130562 0.00210949478512172 0.780849936149854 0.787878787878788 5.4 5 4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 9.50842182728636e-10 9.66463161444893e-09 0.780015694765078 0.787037037037037 5.4 5 4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 4.41546362249641e-06 2.10140626582354e-05 0.779865257794053 0.786885245901639 5.4 5 4 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.41546362249641e-06 2.10140626582354e-05 0.779865257794053 0.786885245901639 5.4 5 4 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.00677842088126e-08 2.1609321681384e-07 0.779500152336285 0.786516853932584 5.4 5 4 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0297730230122467 0.0567922409469532 0.778704744017574 0.785714285714286 5.4 5 4 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0297730230122467 0.0567922409469532 0.778704744017574 0.785714285714286 5.4 5 4 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0297730230122467 0.0567922409469532 0.778704744017574 0.785714285714286 5.4 5 4 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 9.68183621118998e-07 5.17941839418171e-06 0.778704744017574 0.785714285714286 5.4 5 4 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.49884694909885e-09 1.41248954209779e-08 0.77804314270575 0.785046728971963 5.4 5 4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.07789461376146e-13 5.2800786346117e-12 0.777808651101559 0.784810126582278 5.4 5 4 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.73899534877905e-08 3.27358756374397e-07 0.777095849918364 0.784090909090909 5.4 5 4 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 5.70588007795152e-07 3.23484755016933e-06 0.776791464548243 0.783783783783784 5.4 5 4 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 5.70588007795152e-07 3.23484755016933e-06 0.776791464548243 0.783783783783784 5.4 5 4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 6.97326882728245e-06 3.17027525278688e-05 0.776345032672066 0.783333333333333 5.4 5 4 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 6.97326882728245e-06 3.17027525278688e-05 0.776345032672066 0.783333333333333 5.4 5 4 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.52583894081499e-06 7.92433873277274e-06 0.775626859653868 0.782608695652174 5.4 5 4 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00563000061239185 0.0131985022593634 0.775626859653868 0.782608695652174 5.4 5 4 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00563000061239185 0.0131985022593634 0.775626859653868 0.782608695652174 5.4 5 4 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.6617887805373e-11 3.98707940495219e-10 0.774978883998351 0.781954887218045 5.4 5 4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.39661245085141e-09 1.32491967837437e-08 0.774843398179471 0.781818181818182 5.4 5 4 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 6.81068253455401e-17 2.7690289276201e-15 0.773985321326559 0.780952380952381 5.4 5 4 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.96895739055779e-07 4.88997178803208e-06 0.77385602207475 0.780821917808219 5.4 5 4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 8.96895739055779e-07 4.88997178803208e-06 0.77385602207475 0.780821917808219 5.4 5 4 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00316637077423959 0.00796068129283203 0.770839039532548 0.777777777777778 5.4 5 4 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00316637077423959 0.00796068129283203 0.770839039532548 0.777777777777778 5.4 5 4 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00316637077423959 0.00796068129283203 0.770839039532548 0.777777777777778 5.4 5 4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.40477680863427e-06 7.32233479372367e-06 0.770839039532548 0.777777777777778 5.4 5 4 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.40477680863427e-06 7.32233479372367e-06 0.770839039532548 0.777777777777778 5.4 5 4 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000650558280704464 0.00193670383565367 0.770839039532548 0.777777777777778 5.4 5 4 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.000650558280704464 0.00193670383565367 0.770839039532548 0.777777777777778 5.4 5 4 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0161666727915192 0.0323560835194541 0.770839039532548 0.777777777777778 5.4 5 4 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0161666727915192 0.0323560835194541 0.770839039532548 0.777777777777778 5.4 5 4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0161666727915192 0.0323560835194541 0.770839039532548 0.777777777777778 5.4 5 4 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0161666727915192 0.0323560835194541 0.770839039532548 0.777777777777778 5.4 5 4 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0161666727915192 0.0323560835194541 0.770839039532548 0.777777777777778 5.4 5 4 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0920395911426361 0.146750577084522 0.770839039532548 0.777777777777778 5.4 5 4 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0920395911426361 0.146750577084522 0.770839039532548 0.777777777777778 5.4 5 4 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0920395911426361 0.146750577084522 0.770839039532548 0.777777777777778 5.4 5 4 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0920395911426361 0.146750577084522 0.770839039532548 0.777777777777778 5.4 5 4 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0920395911426361 0.146750577084522 0.770839039532548 0.777777777777778 5.4 5 4 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0920395911426361 0.146750577084522 0.770839039532548 0.777777777777778 5.4 5 4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0920395911426361 0.146750577084522 0.770839039532548 0.777777777777778 5.4 5 4 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0920395911426361 0.146750577084522 0.770839039532548 0.777777777777778 5.4 5 4 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.0181677709109e-09 1.86483944026377e-08 0.76985582647192 0.776785714285714 5.4 5 4 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.82226003128899e-07 1.12254373356028e-06 0.769543511735014 0.776470588235294 5.4 5 4 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.82226003128899e-07 1.12254373356028e-06 0.769543511735014 0.776470588235294 5.4 5 4 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.82226003128899e-07 1.12254373356028e-06 0.769543511735014 0.776470588235294 5.4 5 4 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.82226003128899e-07 1.12254373356028e-06 0.769543511735014 0.776470588235294 5.4 5 4 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.82226003128899e-07 1.12254373356028e-06 0.769543511735014 0.776470588235294 5.4 5 4 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.7471213886445e-06 1.80750974103089e-05 0.769195459490901 0.776119402985075 5.4 5 4 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 7.94935339372493e-05 0.00028209301444565 0.768591695393969 0.775510204081633 5.4 5 4 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 7.94935339372493e-05 0.00028209301444565 0.768591695393969 0.775510204081633 5.4 5 4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.19216242805498e-06 1.10618692734831e-05 0.767737071566622 0.774647887323944 5.4 5 4 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.15582041400413e-10 5.18748460449814e-09 0.767286785894149 0.774193548387097 5.4 5 4 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.15582041400413e-10 5.18748460449814e-09 0.767286785894149 0.774193548387097 5.4 5 4 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.15582041400413e-10 5.18748460449814e-09 0.767286785894149 0.774193548387097 5.4 5 4 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00179257037118726 0.00468239413391502 0.767286785894149 0.774193548387097 5.4 5 4 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00179257037118726 0.00468239413391502 0.767286785894149 0.774193548387097 5.4 5 4 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00179257037118726 0.00468239413391502 0.767286785894149 0.774193548387097 5.4 5 4 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000123993205316213 0.000428258085351871 0.76395654810815 0.770833333333333 5.4 5 4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.55601863004928e-05 6.45543589084585e-05 0.763618064923344 0.770491803278688 5.4 5 4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 3.37482574623807e-08 2.35580805541771e-07 0.763130649137223 0.77 5.4 5 4 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 4.60075361720736e-11 6.56261914558672e-10 0.762368280856366 0.769230769230769 5.4 5 4 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0476965760487669 0.0848402846467442 0.762368280856366 0.769230769230769 5.4 5 4 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0476965760487669 0.0848402846467442 0.762368280856366 0.769230769230769 5.4 5 4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0476965760487669 0.0848402846467442 0.762368280856366 0.769230769230769 5.4 5 4 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0476965760487669 0.0848402846467442 0.762368280856366 0.769230769230769 5.4 5 4 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000583021918466464 0.00174294157558357 0.762368280856366 0.769230769230769 5.4 5 4 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 4.15199353927178e-05 0.000160116173614736 0.761006908926266 0.767857142857143 5.4 5 4 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.39927338589923e-05 5.94554374038657e-05 0.758794679539852 0.765625 5.4 5 4 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.39927338589923e-05 5.94554374038657e-05 0.758794679539852 0.765625 5.4 5 4 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.0494870309598e-06 5.59333350208163e-06 0.758603499222508 0.765432098765432 5.4 5 4 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00158808715699497 0.0042082830994485 0.757883761557211 0.764705882352941 5.4 5 4 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00158808715699497 0.0042082830994485 0.757883761557211 0.764705882352941 5.4 5 4 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00158808715699497 0.0042082830994485 0.757883761557211 0.764705882352941 5.4 5 4 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0255690791940989 0.0493018966032557 0.757883761557211 0.764705882352941 5.4 5 4 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0255690791940989 0.0493018966032557 0.757883761557211 0.764705882352941 5.4 5 4 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0255690791940989 0.0493018966032557 0.757883761557211 0.764705882352941 5.4 5 4 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0255690791940989 0.0493018966032557 0.757883761557211 0.764705882352941 5.4 5 4 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.73958649088671e-06 2.24814385884393e-05 0.757074056683753 0.763888888888889 5.4 5 4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.61852527587956e-08 1.20541760383826e-07 0.75682378426832 0.763636363636364 5.4 5 4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 6.40989050628676e-05 0.000234649230951107 0.75682378426832 0.763636363636364 5.4 5 4 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 6.40989050628676e-05 0.000234649230951107 0.75682378426832 0.763636363636364 5.4 5 4 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 6.40989050628676e-05 0.000234649230951107 0.75682378426832 0.763636363636364 5.4 5 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 6.40989050628676e-05 0.000234649230951107 0.75682378426832 0.763636363636364 5.4 5 4 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 6.40989050628676e-05 0.000234649230951107 0.75682378426832 0.763636363636364 5.4 5 4 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 6.40989050628676e-05 0.000234649230951107 0.75682378426832 0.763636363636364 5.4 5 4 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 2.76274617170563e-06 1.36982153391537e-05 0.756349583902237 0.763157894736842 5.4 5 4 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.00961306091969e-11 3.14250481943815e-10 0.75601521184923 0.762820512820513 5.4 5 4 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 9.41212542096684e-07 5.07327820986205e-06 0.755107630562496 0.761904761904762 5.4 5 4 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 9.41212542096684e-07 5.07327820986205e-06 0.755107630562496 0.761904761904762 5.4 5 4 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000517030167970672 0.00154891353478372 0.755107630562496 0.761904761904762 5.4 5 4 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0139895316060009 0.0289347434234584 0.755107630562496 0.761904761904762 5.4 5 4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0139895316060009 0.0289347434234584 0.755107630562496 0.761904761904762 5.4 5 4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0139895316060009 0.0289347434234584 0.755107630562496 0.761904761904762 5.4 5 4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.21612057434463e-07 1.91487011602193e-06 0.754081669107928 0.760869565217391 5.4 5 4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.000296640814995457 0.000925701490654683 0.754081669107928 0.760869565217391 5.4 5 4 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000296640814995457 0.000925701490654683 0.754081669107928 0.760869565217391 5.4 5 4 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00775969868695687 0.0173072903315668 0.75321986148609 0.76 5.4 5 4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00775969868695687 0.0173072903315668 0.75321986148609 0.76 5.4 5 4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 9.84563469620783e-05 0.000345934275869228 0.752485729067488 0.759259259259259 5.4 5 4 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 5.69124656299824e-05 0.000214818139499907 0.75185285629283 0.758620689655172 5.4 5 4 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 5.69124656299824e-05 0.000214818139499907 0.75185285629283 0.758620689655172 5.4 5 4 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.86988692972732e-07 1.72314308059155e-06 0.751133379875325 0.757894736842105 5.4 5 4 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00139264281175429 0.00373911456816294 0.750005551977614 0.756756756756757 5.4 5 4 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 6.80300973171141e-09 5.66121803989785e-08 0.749352237036867 0.75609756097561 5.4 5 4 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.20225452306064e-11 3.40631324599488e-10 0.749352237036867 0.75609756097561 5.4 5 4 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000794280348566226 0.00231379676376861 0.749352237036867 0.75609756097561 5.4 5 4 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000454754811128706 0.0014067741222525 0.748815066974475 0.755555555555556 5.4 5 4 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000150435391165728 0.000508478768714564 0.747983973670397 0.754716981132076 5.4 5 4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.20094489121054e-54 8.54472290096297e-52 0.747793593134112 0.754524886877828 5.4 5 4 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.38400344261712e-12 2.43140357881995e-11 0.747283988668299 0.754010695187166 5.4 5 4 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.68930340060754e-05 6.98801959030388e-05 0.746899938925947 0.753623188405797 5.4 5 4 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 4.74428967258396e-12 7.94249906363173e-11 0.743309073834957 0.75 5.4 5 4 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00121189745836635 0.00340144000642074 0.743309073834957 0.75 5.4 5 4 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00667917369606293 0.0152195490498234 0.743309073834957 0.75 5.4 5 4 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0119667558547342 0.0248957508498345 0.743309073834957 0.75 5.4 5 4 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0119667558547342 0.0248957508498345 0.743309073834957 0.75 5.4 5 4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0119667558547342 0.0248957508498345 0.743309073834957 0.75 5.4 5 4 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0216783831711308 0.0421425399624577 0.743309073834957 0.75 5.4 5 4 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0216783831711308 0.0421425399624577 0.743309073834957 0.75 5.4 5 4 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0751522560435921 0.122079520947525 0.743309073834957 0.75 5.4 5 4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0751522560435921 0.122079520947525 0.743309073834957 0.75 5.4 5 4 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0751522560435921 0.122079520947525 0.743309073834957 0.75 5.4 5 4 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0751522560435921 0.122079520947525 0.743309073834957 0.75 5.4 5 4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0751522560435921 0.122079520947525 0.743309073834957 0.75 5.4 5 4 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0398879966995042 0.0717580522166808 0.743309073834957 0.75 5.4 5 4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0398879966995042 0.0717580522166808 0.743309073834957 0.75 5.4 5 4 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0398879966995042 0.0717580522166808 0.743309073834957 0.75 5.4 5 4 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.147462324382762 0.213034403651442 0.743309073834957 0.75 5.4 5 4 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.02887162690951e-07 6.77816817172332e-07 0.741076914454071 0.747747747747748 5.4 5 4 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.63423206201572e-45 9.37128056062092e-43 0.739819359873291 0.746478873239437 5.4 5 4 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.73406106258649e-15 5.25014657885228e-14 0.739376221592444 0.746031746031746 5.4 5 4 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.73406106258649e-15 5.25014657885228e-14 0.739376221592444 0.746031746031746 5.4 5 4 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.73406106258649e-15 5.25014657885228e-14 0.739376221592444 0.746031746031746 5.4 5 4 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000114990448098149 0.000400076791304805 0.739109587542104 0.745762711864407 5.4 5 4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 4.90909123786468e-31 7.76181870164604e-29 0.738669191975813 0.745318352059925 5.4 5 4 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.86306381029566e-06 1.85714182501714e-05 0.737546987991275 0.744186046511628 5.4 5 4 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 3.36133762732727e-05 0.000133236307623585 0.736229939798434 0.742857142857143 5.4 5 4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00570920662091025 0.0133621727328212 0.73531650314856 0.741935483870968 5.4 5 4 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000298946946033301 0.000930856683162772 0.734132418602427 0.740740740740741 5.4 5 4 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0101632846678255 0.0219792615232762 0.734132418602427 0.740740740740741 5.4 5 4 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0101632846678255 0.0219792615232762 0.734132418602427 0.740740740740741 5.4 5 4 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0101632846678255 0.0219792615232762 0.734132418602427 0.740740740740741 5.4 5 4 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 5.87278538127328e-07 3.31625936410789e-06 0.733779470324253 0.740384615384615 5.4 5 4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 3.55176990586766e-08 2.46544808587789e-07 0.733554361579905 0.740157480314961 5.4 5 4 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0182510181478274 0.0363043714682448 0.732536478561987 0.739130434782609 5.4 5 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.01896820708481e-06 2.3648979333383e-05 0.732046815140488 0.738636363636364 5.4 5 4 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00157562176660825 0.00419870744172949 0.731510517107418 0.738095238095238 5.4 5 4 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.54604608642007e-06 1.27571252851259e-05 0.730268563767677 0.736842105263158 5.4 5 4 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.54604608642007e-06 1.27571252851259e-05 0.730268563767677 0.736842105263158 5.4 5 4 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0331628825601179 0.0616872965791474 0.730268563767677 0.736842105263158 5.4 5 4 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.44679489297274e-06 3.3747736091402e-05 0.729069436405169 0.735632183908046 5.4 5 4 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.44286816713108e-09 2.21414102027231e-08 0.728922446599442 0.735483870967742 5.4 5 4 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.004856448657985 0.0114605745278817 0.728734386112703 0.735294117647059 5.4 5 4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.004856448657985 0.0114605745278817 0.728734386112703 0.735294117647059 5.4 5 4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.004856448657985 0.0114605745278817 0.728734386112703 0.735294117647059 5.4 5 4 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.004856448657985 0.0114605745278817 0.728734386112703 0.735294117647059 5.4 5 4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.00859153121166536 0.0187799522491549 0.726791094416403 0.733333333333333 5.4 5 4 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00859153121166536 0.0187799522491549 0.726791094416403 0.733333333333333 5.4 5 4 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0612742885348223 0.105104588207415 0.726791094416403 0.733333333333333 5.4 5 4 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0612742885348223 0.105104588207415 0.726791094416403 0.733333333333333 5.4 5 4 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0612742885348223 0.105104588207415 0.726791094416403 0.733333333333333 5.4 5 4 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0612742885348223 0.105104588207415 0.726791094416403 0.733333333333333 5.4 5 4 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0153035488000628 0.0313788904070452 0.724249866813548 0.730769230769231 5.4 5 4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0153035488000628 0.0313788904070452 0.724249866813548 0.730769230769231 5.4 5 4 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0153035488000628 0.0313788904070452 0.724249866813548 0.730769230769231 5.4 5 4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.08772129375792e-10 1.4741213343024e-09 0.722661599561764 0.729166666666667 5.4 5 4 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00114868809990696 0.00323040151416522 0.722661599561764 0.729166666666667 5.4 5 4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00114868809990696 0.00323040151416522 0.722661599561764 0.729166666666667 5.4 5 4 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 6.71932171240540e-09 5.62446752750169e-08 0.722528390050324 0.729032258064516 5.4 5 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000162736783550905 0.000548754604248667 0.720784556446019 0.727272727272727 5.4 5 4 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0275017759701048 0.0527616106609188 0.720784556446019 0.727272727272727 5.4 5 4 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.116156822396404 0.176593117809917 0.720784556446019 0.727272727272727 5.4 5 4 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00348083606548886 0.00858445358958517 0.718532104707125 0.725 5.4 5 4 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 6.93561254476959e-05 0.000247974287718772 0.717228053700397 0.723684210526316 5.4 5 4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 6.93561254476959e-05 0.000247974287718772 0.717228053700397 0.723684210526316 5.4 5 4 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0500153358408061 0.0887429213235251 0.715779108137366 0.722222222222222 5.4 5 4 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0014318818753957 0.00383722769997757 0.713576710881559 0.72 5.4 5 4 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0227849028575902 0.0441729111258186 0.713576710881559 0.72 5.4 5 4 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 9.60486683027719e-07 5.15763226395639e-06 0.712593822850042 0.71900826446281 5.4 5 4 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 8.20821081761896e-07 4.50976215964162e-06 0.711338791089368 0.717741935483871 5.4 5 4 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.15299631678834e-07 2.41212806481217e-06 0.71115575511945 0.717557251908397 5.4 5 4 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.15299631678834e-07 2.41212806481217e-06 0.71115575511945 0.717557251908397 5.4 5 4 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.79702129768625e-07 1.12254373356028e-06 0.70992166862724 0.716312056737589 5.4 5 4 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.07498747034377e-68 4.37570717029918e-65 0.708918832631059 0.715300193673338 5.4 5 4 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0925054586400677 0.146750577084522 0.70791340365234 0.714285714285714 5.4 5 4 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0925054586400677 0.146750577084522 0.70791340365234 0.714285714285714 5.4 5 4 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.0925054586400677 0.146750577084522 0.70791340365234 0.714285714285714 5.4 5 4 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0925054586400677 0.146750577084522 0.70791340365234 0.714285714285714 5.4 5 4 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0925054586400677 0.146750577084522 0.70791340365234 0.714285714285714 5.4 5 4 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0925054586400677 0.146750577084522 0.70791340365234 0.714285714285714 5.4 5 4 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.230230366737549 0.313210145188845 0.70791340365234 0.714285714285714 5.4 5 4 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.230230366737549 0.313210145188845 0.70791340365234 0.714285714285714 5.4 5 4 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.230230366737549 0.313210145188845 0.70791340365234 0.714285714285714 5.4 5 4 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.230230366737549 0.313210145188845 0.70791340365234 0.714285714285714 5.4 5 4 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.230230366737549 0.313210145188845 0.70791340365234 0.714285714285714 5.4 5 4 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.230230366737549 0.313210145188845 0.70791340365234 0.714285714285714 5.4 5 4 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0409005120839552 0.0733939832225324 0.70791340365234 0.714285714285714 5.4 5 4 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00744660228393008 0.0166874252756417 0.704187543633117 0.710526315789474 5.4 5 4 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00744660228393008 0.0166874252756417 0.704187543633117 0.710526315789474 5.4 5 4 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00744660228393008 0.0166874252756417 0.704187543633117 0.710526315789474 5.4 5 4 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00147387650861436 0.00393494610085972 0.702764942534869 0.709090909090909 5.4 5 4 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0335127980024822 0.0621241787115731 0.702014125288571 0.708333333333333 5.4 5 4 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00123846439901377 0.00344311359795663 0.700590161545592 0.706896551724138 5.4 5 4 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00123846439901377 0.00344311359795663 0.700590161545592 0.706896551724138 5.4 5 4 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00123846439901377 0.00344311359795663 0.700590161545592 0.706896551724138 5.4 5 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0742533987124768 0.121311809836802 0.699585010668195 0.705882352941177 5.4 5 4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0742533987124768 0.121311809836802 0.699585010668195 0.705882352941177 5.4 5 4 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0275116761141263 0.0527616106609188 0.697425797672306 0.703703703703704 5.4 5 4 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0275116761141263 0.0527616106609188 0.697425797672306 0.703703703703704 5.4 5 4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.15009091214507e-08 9.40562855162322e-08 0.696852256720272 0.703125 5.4 5 4 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.24005690143094e-19 7.05840388294489e-18 0.694756225241024 0.701010101010101 5.4 5 4 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.175538927060002 0.250292478162709 0.693755135579293 0.7 5.4 5 4 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.175538927060002 0.250292478162709 0.693755135579293 0.7 5.4 5 4 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.175538927060002 0.250292478162709 0.693755135579293 0.7 5.4 5 4 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.175538927060002 0.250292478162709 0.693755135579293 0.7 5.4 5 4 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.175538927060002 0.250292478162709 0.693755135579293 0.7 5.4 5 4 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.175538927060002 0.250292478162709 0.693755135579293 0.7 5.4 5 4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.175538927060002 0.250292478162709 0.693755135579293 0.7 5.4 5 4 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00740729242361097 0.0166781283525291 0.69145030124182 0.697674418604651 5.4 5 4 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.018636074458369 0.0368833573772727 0.690751866594102 0.696969696969697 5.4 5 4 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0486463652781676 0.086421695119641 0.689446097470105 0.695652173913043 5.4 5 4 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.16119570570059e-21 2.24919074460597e-19 0.689068773642681 0.695271453590193 5.4 5 4 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00511659092702068 0.012054484915812 0.687687306405131 0.693877551020408 5.4 5 4 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.65700148293857e-12 2.87550379295315e-11 0.687066873974234 0.693251533742331 5.4 5 4 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0396179494870267 0.0715435813706079 0.68613145277073 0.692307692307692 5.4 5 4 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0396179494870267 0.0715435813706079 0.68613145277073 0.692307692307692 5.4 5 4 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.136927536031949 0.200874106982951 0.68613145277073 0.692307692307692 5.4 5 4 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.136927536031949 0.200874106982951 0.68613145277073 0.692307692307692 5.4 5 4 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.136927536031949 0.200874106982951 0.68613145277073 0.692307692307692 5.4 5 4 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.136927536031949 0.200874106982951 0.68613145277073 0.692307692307692 5.4 5 4 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.41809660079336e-23 4.28330636829386e-21 0.68589432422303 0.692068429237947 5.4 5 4 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00869328796972795 0.0189732343265688 0.682743149300257 0.688888888888889 5.4 5 4 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.2713360291275e-05 9.2331951133244e-05 0.682382100569797 0.688524590163934 5.4 5 4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00720410081438385 0.0162463319474932 0.681366651015377 0.6875 5.4 5 4 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.108324130572522 0.170326229618452 0.681366651015377 0.6875 5.4 5 4 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.108324130572522 0.170326229618452 0.681366651015377 0.6875 5.4 5 4 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.108324130572522 0.170326229618452 0.681366651015377 0.6875 5.4 5 4 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00412098722522402 0.0098227216440432 0.678106523498557 0.684210526315789 5.4 5 4 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0147552660011291 0.0303860253539895 0.676834278613945 0.682926829268293 5.4 5 4 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0147552660011291 0.0303860253539895 0.676834278613945 0.682926829268293 5.4 5 4 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00285009293045867 0.00720369847254474 0.676450585712236 0.682539682539683 5.4 5 4 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0696120894707772 0.114122123637 0.675735521668143 0.681818181818182 5.4 5 4 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.8917497633965e-06 1.86463296744553e-05 0.675448585140895 0.681528662420382 5.4 5 4 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0563095751853777 0.097837027458843 0.673933560277028 0.68 5.4 5 4 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0563095751853777 0.097837027458843 0.673933560277028 0.68 5.4 5 4 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 8.37719234457168e-31 1.19207447063255e-28 0.673616097609524 0.67967967967968 5.4 5 4 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.92079801493435e-14 5.35940308872858e-13 0.67331135836171 0.679372197309417 5.4 5 4 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0457476945942364 0.0817826248839177 0.672517733469723 0.678571428571429 5.4 5 4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.74318038165316e-15 1.37745830267193e-13 0.668776727678064 0.67479674796748 5.4 5 4 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0139401705631518 0.0289347434234584 0.667900906924164 0.673913043478261 5.4 5 4 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000259207848660141 0.000844056678817806 0.666894122319214 0.672897196261682 5.4 5 4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.00541123168646294 0.0127275746939451 0.666134907699087 0.672131147540984 5.4 5 4 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.62642431438473e-08 1.20541760383826e-07 0.661911810635221 0.667870036101083 5.4 5 4 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0422675512226264 0.0756562583519464 0.660719176742184 0.666666666666667 5.4 5 4 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00202108766902618 0.00517059179328322 0.660719176742184 0.666666666666667 5.4 5 4 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0107672229473699 0.0232500125252009 0.660719176742184 0.666666666666667 5.4 5 4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0518508989790366 0.0918852169952293 0.660719176742184 0.666666666666667 5.4 5 4 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0638304962328274 0.105104588207415 0.660719176742184 0.666666666666667 5.4 5 4 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.154967798850559 0.223197548344479 0.660719176742184 0.666666666666667 5.4 5 4 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.198165955102027 0.272981756157003 0.660719176742184 0.666666666666667 5.4 5 4 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.198165955102027 0.272981756157003 0.660719176742184 0.666666666666667 5.4 5 4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.198165955102027 0.272981756157003 0.660719176742184 0.666666666666667 5.4 5 4 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.198165955102027 0.272981756157003 0.660719176742184 0.666666666666667 5.4 5 4 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.198165955102027 0.272981756157003 0.660719176742184 0.666666666666667 5.4 5 4 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.198165955102027 0.272981756157003 0.660719176742184 0.666666666666667 5.4 5 4 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.198165955102027 0.272981756157003 0.660719176742184 0.666666666666667 5.4 5 4 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0191447893445284 0.0378375489406444 0.660719176742184 0.666666666666667 5.4 5 4 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0283233818845767 0.0542451849552526 0.660719176742184 0.666666666666667 5.4 5 4 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.122729524455818 0.186386460299498 0.660719176742184 0.666666666666667 5.4 5 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.258307790863014 0.337222005869788 0.660719176742184 0.666666666666667 5.4 5 4 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.258307790863014 0.337222005869788 0.660719176742184 0.666666666666667 5.4 5 4 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.258307790863014 0.337222005869788 0.660719176742184 0.666666666666667 5.4 5 4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.258307790863014 0.337222005869788 0.660719176742184 0.666666666666667 5.4 5 4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.258307790863014 0.337222005869788 0.660719176742184 0.666666666666667 5.4 5 4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.258307790863014 0.337222005869788 0.660719176742184 0.666666666666667 5.4 5 4 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.258307790863014 0.337222005869788 0.660719176742184 0.666666666666667 5.4 5 4 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0176898313115636 0.0353548173544312 0.654111984974762 0.66 5.4 5 4 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0014706381356883 0.00393368057722642 0.653690249330033 0.659574468085106 5.4 5 4 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00922962719969374 0.0201129548317982 0.650395439605587 0.65625 5.4 5 4 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0711711662395249 0.116543808468175 0.649327466798353 0.655172413793103 5.4 5 4 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 5.59813539863136e-07 3.19925569166764e-06 0.649059426564381 0.654901960784314 5.4 5 4 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0878382015044846 0.14187714045503 0.648013038727911 0.653846153846154 5.4 5 4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.10892282233192 0.171078560903226 0.646355716378224 0.652173913043478 5.4 5 4 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.170787138982605 0.245237233877141 0.641286259779179 0.647058823529412 5.4 5 4 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0317946861114429 0.0595034907012868 0.640071702468991 0.645833333333333 5.4 5 4 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.216887275337334 0.297331977654168 0.637122063287106 0.642857142857143 5.4 5 4 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.216887275337334 0.297331977654168 0.637122063287106 0.642857142857143 5.4 5 4 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.216887275337334 0.297331977654168 0.637122063287106 0.642857142857143 5.4 5 4 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.216887275337334 0.297331977654168 0.637122063287106 0.642857142857143 5.4 5 4 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.216887275337334 0.297331977654168 0.637122063287106 0.642857142857143 5.4 5 4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.02145432320263 0.0418212355032088 0.633640521957668 0.639344262295082 5.4 5 4 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0161025692442991 0.0323560835194541 0.631992256014263 0.63768115942029 5.4 5 4 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0852304008667597 0.137978225749032 0.630686486890267 0.636363636363636 5.4 5 4 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0852304008667597 0.137978225749032 0.630686486890267 0.636363636363636 5.4 5 4 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0852304008667597 0.137978225749032 0.630686486890267 0.636363636363636 5.4 5 4 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.147896421323366 0.213228579071073 0.630686486890267 0.636363636363636 5.4 5 4 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.147896421323366 0.213228579071073 0.630686486890267 0.636363636363636 5.4 5 4 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.2794576102213 0.363167287072977 0.630686486890267 0.636363636363636 5.4 5 4 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.2794576102213 0.363167287072977 0.630686486890267 0.636363636363636 5.4 5 4 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.2794576102213 0.363167287072977 0.630686486890267 0.636363636363636 5.4 5 4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.2794576102213 0.363167287072977 0.630686486890267 0.636363636363636 5.4 5 4 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.2794576102213 0.363167287072977 0.630686486890267 0.636363636363636 5.4 5 4 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.00440850531485749 0.0104904733495689 0.628953831706502 0.634615384615385 5.4 5 4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.104542536962186 0.164926862635467 0.627683217905075 0.633333333333333 5.4 5 4 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.00747963991394672 0.01673510628545 0.625944483229438 0.631578947368421 5.4 5 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.184787592753283 0.262952744487922 0.625944483229438 0.631578947368421 5.4 5 4 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0141259915964805 0.0291745806121796 0.624012555812063 0.62962962962963 5.4 5 4 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.022523589133828 0.0437258763130113 0.622963795214059 0.628571428571429 5.4 5 4 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0919310377242784 0.146750577084522 0.622963795214059 0.628571428571429 5.4 5 4 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0919310377242784 0.146750577084522 0.622963795214059 0.628571428571429 5.4 5 4 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.112339055202093 0.173382294525573 0.619424228195798 0.625 5.4 5 4 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.23270724598062 0.315373724790878 0.619424228195798 0.625 5.4 5 4 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.23270724598062 0.315373724790878 0.619424228195798 0.625 5.4 5 4 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.23270724598062 0.315373724790878 0.619424228195798 0.625 5.4 5 4 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.23270724598062 0.315373724790878 0.619424228195798 0.625 5.4 5 4 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.368177103995528 0.45877059455835 0.619424228195798 0.625 5.4 5 4 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.368177103995528 0.45877059455835 0.619424228195798 0.625 5.4 5 4 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.368177103995528 0.45877059455835 0.619424228195798 0.625 5.4 5 4 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.368177103995528 0.45877059455835 0.619424228195798 0.625 5.4 5 4 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%REACT_208465.1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS 0.368177103995528 0.45877059455835 0.619424228195798 0.625 5.4 5 4 EARLY STAGE PANCREATIC PRECURSOR CELLS%REACTOME%REACT_13403.1 EARLY STAGE PANCREATIC PRECURSOR CELLS 0.368177103995528 0.45877059455835 0.619424228195798 0.625 5.4 5 4 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.368177103995528 0.45877059455835 0.619424228195798 0.625 5.4 5 4 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0671352883050239 0.110188598913551 0.609894624685093 0.615384615384615 5.4 5 4 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.296147425614153 0.384505279789178 0.609894624685093 0.615384615384615 5.4 5 4 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.146079525879466 0.213034403651442 0.607435372166202 0.612903225806452 5.4 5 4 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0336233159056046 0.0621241787115731 0.596778611251005 0.602150537634409 5.4 5 4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0937805047746078 0.148607637298738 0.594647259067966 0.6 5.4 5 4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.218698517460986 0.299526458466778 0.594647259067966 0.6 5.4 5 4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00465755688518372 0.0110646134350859 0.594647259067966 0.6 5.4 5 4 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.187260204551039 0.264184463550015 0.594647259067966 0.6 5.4 5 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.309766490067497 0.40094961302765 0.594647259067966 0.6 5.4 5 4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.382461086567532 0.474905869271901 0.594647259067966 0.6 5.4 5 4 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.382461086567532 0.474905869271901 0.594647259067966 0.6 5.4 5 4 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.382461086567532 0.474905869271901 0.594647259067966 0.6 5.4 5 4 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.382461086567532 0.474905869271901 0.594647259067966 0.6 5.4 5 4 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00594294377284262 0.0138863858600247 0.588610231057123 0.593908629441624 5.4 5 4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.195392521484856 0.270997619954143 0.588453016786008 0.59375 5.4 5 4 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0592210845066126 0.102770247869402 0.58563745211239 0.590909090909091 5.4 5 4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0614322540910771 0.105104588207415 0.583635272788929 0.588888888888889 5.4 5 4 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.32116454169207 0.407323656709283 0.582987508890162 0.588235294117647 5.4 5 4 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.158086930968615 0.227459760129766 0.581720144740401 0.58695652173913 5.4 5 4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.393265927388282 0.487047358288533 0.578129279649411 0.583333333333333 5.4 5 4 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.393265927388282 0.487047358288533 0.578129279649411 0.583333333333333 5.4 5 4 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.330894397835396 0.419290051754024 0.573782442960318 0.578947368421053 5.4 5 4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.103352009360916 0.163229644084999 0.571327758712359 0.576470588235294 5.4 5 4 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.103352009360916 0.163229644084999 0.571327758712359 0.576470588235294 5.4 5 4 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0405023936288096 0.0727713461285304 0.568057340979561 0.573170731707317 5.4 5 4 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.401827625983244 0.495924294687039 0.566330722921872 0.571428571428571 5.4 5 4 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.401827625983244 0.495924294687039 0.566330722921872 0.571428571428571 5.4 5 4 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.401827625983244 0.495924294687039 0.566330722921872 0.571428571428571 5.4 5 4 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.0207954197106925 0.0405924310676481 0.565723071931613 0.570815450643777 5.4 5 4 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.300803215275789 0.390194143425202 0.561611300230856 0.566666666666667 5.4 5 4 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0260878806396513 0.0502341734103164 0.559668008534556 0.564705882352941 5.4 5 4 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.218912744851889 0.299531573004075 0.558608031245665 0.563636363636364 5.4 5 4 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.145285073880299 0.212656597482674 0.555004108463435 0.56 5.4 5 4 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.353336304232753 0.442993445747319 0.555004108463435 0.56 5.4 5 4 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0860156695169135 0.139091247412009 0.554019185467049 0.559006211180124 5.4 5 4 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.099888757708265 0.158110903469256 0.55059931395182 0.555555555555556 5.4 5 4 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.414737409401285 0.511413633949765 0.55059931395182 0.555555555555556 5.4 5 4 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.505513745411169 0.582159145023787 0.55059931395182 0.555555555555556 5.4 5 4 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.505513745411169 0.582159145023787 0.55059931395182 0.555555555555556 5.4 5 4 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.505513745411169 0.582159145023787 0.55059931395182 0.555555555555556 5.4 5 4 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.505513745411169 0.582159145023787 0.55059931395182 0.555555555555556 5.4 5 4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.505513745411169 0.582159145023787 0.55059931395182 0.555555555555556 5.4 5 4 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.115221088449563 0.176593117809917 0.547221404050275 0.552147239263804 5.4 5 4 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.41978950415513 0.517195207283766 0.545093320812302 0.55 5.4 5 4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.145407497786818 0.212656597482674 0.542288380911038 0.547169811320755 5.4 5 4 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.145407497786818 0.212656597482674 0.542288380911038 0.547169811320755 5.4 5 4 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.42418857337309 0.521261088005101 0.540588417334514 0.545454545454545 5.4 5 4 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.506065258183011 0.582159145023787 0.540588417334514 0.545454545454545 5.4 5 4 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.506065258183011 0.582159145023787 0.540588417334514 0.545454545454545 5.4 5 4 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.506065258183011 0.582159145023787 0.540588417334514 0.545454545454545 5.4 5 4 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.506065258183011 0.582159145023787 0.540588417334514 0.545454545454545 5.4 5 4 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.506065258183011 0.582159145023787 0.540588417334514 0.545454545454545 5.4 5 4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.506065258183011 0.582159145023787 0.540588417334514 0.545454545454545 5.4 5 4 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.506065258183011 0.582159145023787 0.540588417334514 0.545454545454545 5.4 5 4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.506065258183011 0.582159145023787 0.540588417334514 0.545454545454545 5.4 5 4 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.181394719030863 0.258383068249168 0.537100750125905 0.541935483870968 5.4 5 4 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.506570846124765 0.582270043647448 0.533657796599456 0.538461538461538 5.4 5 4 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.38528405540779 0.477994080946194 0.533657796599456 0.538461538461538 5.4 5 4 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.44005090490452 0.539821066964769 0.526510593966428 0.53125 5.4 5 4 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.426592238830978 0.523762515838207 0.514357333792966 0.518987341772152 5.4 5 4 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.420461772785868 0.517575348334161 0.509697650629685 0.514285714285714 5.4 5 4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.421308167936656 0.518168991334366 0.509498238403304 0.514084507042254 5.4 5 4 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.452846976627857 0.555039834402619 0.506390609911893 0.510948905109489 5.4 5 4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.486671251343738 0.582159145023787 0.502826726417765 0.507352941176471 5.4 5 4 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.393899013891291 0.487407214580266 0.500857366174319 0.505365853658537 5.4 5 4 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.520992941864263 0.598363967936115 0.499156458341723 0.503649635036496 5.4 5 4 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.611314066266287 0.697035189340486 0.495539382556638 0.5 5.4 5 4 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.611314066266287 0.697035189340486 0.495539382556638 0.5 5.4 5 4 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.611314066266287 0.697035189340486 0.495539382556638 0.5 5.4 5 4 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.611314066266287 0.697035189340486 0.495539382556638 0.5 5.4 5 4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.596003118127192 0.683410505314258 0.495539382556638 0.5 5.4 5 4 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.618864588977739 0.703952286263248 0.495539382556638 0.5 5.4 5 4 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.618864588977739 0.703952286263248 0.495539382556638 0.5 5.4 5 4 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.618864588977739 0.703952286263248 0.495539382556638 0.5 5.4 5 4 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.628566404254806 0.713277506582607 0.495539382556638 0.5 5.4 5 4 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.628566404254806 0.713277506582607 0.495539382556638 0.5 5.4 5 4 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.628566404254806 0.713277506582607 0.495539382556638 0.5 5.4 5 4 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.605238044451853 0.692326155349667 0.495539382556638 0.5 5.4 5 4 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.605238044451853 0.692326155349667 0.495539382556638 0.5 5.4 5 4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.595599010709784 0.683410505314258 0.492985055842429 0.497422680412371 5.4 5 4 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.600765816064882 0.688317034026028 0.491999815538376 0.496428571428571 5.4 5 4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.638981371956469 0.724518320553033 0.482146426271323 0.486486486486487 5.4 5 4 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.741611803020431 0.822151531750927 0.470512141013374 0.474747474747475 5.4 5 4 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.811490435732329 0.882837071901456 0.470419874685103 0.474654377880184 5.4 5 4 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.692133599254706 0.772475381756428 0.46639000711213 0.470588235294118 5.4 5 4 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.692133599254706 0.772475381756428 0.46639000711213 0.470588235294118 5.4 5 4 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.702553565598204 0.783490379189847 0.462503423719529 0.466666666666667 5.4 5 4 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.715116368566002 0.796875953382475 0.45742096851382 0.461538461538462 5.4 5 4 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.789186882202103 0.860546309098539 0.454921400379864 0.459016393442623 5.4 5 4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.736729103973413 0.819675930378551 0.454244434010252 0.458333333333333 5.4 5 4 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.730650692647969 0.813549245413192 0.450490347778762 0.454545454545455 5.4 5 4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.950303176675175 0.996522785857608 0.439228089084293 0.443181818181818 5.4 5 4 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.871351822717705 0.935093245646526 0.430090784860478 0.433962264150943 5.4 5 4 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.792968095290789 0.863346288904967 0.424748042191404 0.428571428571429 5.4 5 4 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.792968095290789 0.863346288904967 0.424748042191404 0.428571428571429 5.4 5 4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.825547511488075 0.894709907728508 0.417296322152958 0.421052631578947 5.4 5 4 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.865108428663997 0.930498332569061 0.415613675692664 0.419354838709677 5.4 5 4 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.865108428663997 0.930498332569061 0.415613675692664 0.419354838709677 5.4 5 4 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.865108428663997 0.930498332569061 0.415613675692664 0.419354838709677 5.4 5 4 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.890378372944271 0.948735883907202 0.408091256223114 0.411764705882353 5.4 5 4 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.853244448419178 0.922619187006452 0.39643150604531 0.4 5.4 5 4 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.872740505706643 0.935173107103181 0.39643150604531 0.4 5.4 5 4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.947826699165415 0.995392909898439 0.392302011190672 0.395833333333333 5.4 5 4 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.922539979477798 0.976040439254206 0.390424968074927 0.393939393939394 5.4 5 4 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.960167031154082 1 0.384295847696985 0.387755102040816 5.4 5 4 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.870111372673571 0.934466779859994 0.381184140428183 0.384615384615385 5.4 5 4 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.870111372673571 0.934466779859994 0.381184140428183 0.384615384615385 5.4 5 4 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999643593805043 1 0.378315012489476 0.381720430107527 5.4 5 4 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.908875773814065 0.965171810550309 0.377553815281248 0.380952380952381 5.4 5 4 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.941799650616268 0.991258064221116 0.367066209301213 0.37037037037037 5.4 5 4 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.994322155723377 1 0.363813723902342 0.367088607594937 5.4 5 4 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.992387458990821 1 0.362930252013312 0.366197183098592 5.4 5 4 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.935851721906116 0.98865404623044 0.36039227822301 0.363636363636364 5.4 5 4 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.935851721906116 0.98865404623044 0.36039227822301 0.363636363636364 5.4 5 4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.981509826339523 1 0.358475298019696 0.361702127659574 5.4 5 4 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.948598646217508 0.995468933309376 0.356788355440779 0.36 5.4 5 4 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.958630509779164 1 0.35395670182617 0.357142857142857 5.4 5 4 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.980840788678463 1 0.339798433753123 0.342857142857143 5.4 5 4 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.979879929840004 1 0.330359588371092 0.333333333333333 5.4 5 4 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.983199378693408 1 0.318561031643553 0.321428571428571 5.4 5 4 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.307891807801773 0.310663308144416 5.4 5 4 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999388944422 1 0.27529965697591 0.277777777777778 5.4 5 4 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999515009659314 1 0.274128169073885 0.276595744680851 5.4 5 4 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.272412246468749 0.274864376130199 5.4 5 4 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.999249284747522 1 0.260810201345599 0.263157894736842 5.4 5 4 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999973189981515 1 0.227122217005126 0.229166666666667 5.4 5 4 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.999600047679498 1 0.223791979219127 0.225806451612903 5.4 5 4 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999996977555 1 0.209227739301692 0.211111111111111 5.4 5 4 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0319702827455896 0.032258064516129 5.4 5 4 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 6.88333291912971e-08 5.97255045361072e-07 1.19232260566111 1 5.2 5 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 3.49700316514934e-06 1.65323438671346e-05 1.19232260566111 1 5.2 5 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 1.68247225327163e-05 7.18966371292954e-05 1.19232260566111 1 5.2 5 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 1.68247225327163e-05 7.18966371292954e-05 1.19232260566111 1 5.2 5 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 1.68247225327163e-05 7.18966371292954e-05 1.19232260566111 1 5.2 5 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 1.68247225327163e-05 7.18966371292954e-05 1.19232260566111 1 5.2 5 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 8.09354269494547e-05 0.000306306150396473 1.19232260566111 1 5.2 5 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 8.09354269494547e-05 0.000306306150396473 1.19232260566111 1 5.2 5 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 8.09354269494547e-05 0.000306306150396473 1.19232260566111 1 5.2 5 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 8.09354269494547e-05 0.000306306150396473 1.19232260566111 1 5.2 5 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000177505214650253 0.000633666583785235 1.19232260566111 1 5.2 5 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.000177505214650253 0.000633666583785235 1.19232260566111 1 5.2 5 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000389285556754312 0.0012763902010631 1.19232260566111 1 5.2 5 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.000389285556754312 0.0012763902010631 1.19232260566111 1 5.2 5 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000389285556754312 0.0012763902010631 1.19232260566111 1 5.2 5 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000389285556754312 0.0012763902010631 1.19232260566111 1 5.2 5 2 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.000853709644831715 0.00255753436756954 1.19232260566111 1 5.2 5 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.000853709644831715 0.00255753436756954 1.19232260566111 1 5.2 5 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000853709644831715 0.00255753436756954 1.19232260566111 1 5.2 5 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00187213347433806 0.0051729047261807 1.19232260566111 1 5.2 5 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00187213347433806 0.0051729047261807 1.19232260566111 1 5.2 5 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00187213347433806 0.0051729047261807 1.19232260566111 1 5.2 5 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00187213347433806 0.0051729047261807 1.19232260566111 1 5.2 5 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00410533077190949 0.0105069886482504 1.19232260566111 1 5.2 5 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00410533077190949 0.0105069886482504 1.19232260566111 1 5.2 5 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00410533077190949 0.0105069886482504 1.19232260566111 1 5.2 5 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00410533077190949 0.0105069886482504 1.19232260566111 1 5.2 5 2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00410533077190949 0.0105069886482504 1.19232260566111 1 5.2 5 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00410533077190949 0.0105069886482504 1.19232260566111 1 5.2 5 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_223937.1 FGFR2B LIGAND BINDING AND ACTIVATION 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.00900210816664249 0.0209313724201508 1.19232260566111 1 5.2 5 2 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%REACT_208690.1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%REACT_209262.1 CLEAVAGE OF THE DAMAGED PYRIMIDINE 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220836.1 FGFR1B LIGAND BINDING AND ACTIVATION 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605564 MUSCARINIC ACETYLCHOLINE RECEPTORS 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 DEPYRIMIDINATION%REACTOME%REACT_206945.1 DEPYRIMIDINATION 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0197389945636012 0.0405318748398333 1.19232260566111 1 5.2 5 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 4.56568526904418e-09 4.99766933680759e-08 1.15120803305211 0.96551724137931 5.2 5 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 9.16478681634772e-08 7.40993843162659e-07 1.14462970143466 0.96 5.2 5 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 7.84503059710291e-06 3.57803799348636e-05 1.12956878431052 0.947368421052632 5.2 5 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 2.37007680097023e-10 3.53596657307417e-09 1.12787273508483 0.945945945945946 5.2 5 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 4.92724270407214e-10 6.1482762713077e-09 1.12608246090216 0.944444444444444 5.2 5 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 3.3941598374306e-05 0.000136824063701522 1.12218598179869 0.941176470588235 5.2 5 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 3.3941598374306e-05 0.000136824063701522 1.12218598179869 0.941176470588235 5.2 5 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 4.3847682291018e-09 4.83684123256733e-08 1.12006062956044 0.939393939393939 5.2 5 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 7.02746300719406e-05 0.000269543931515826 1.11780244280729 0.9375 5.2 5 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 7.02746300719406e-05 0.000269543931515826 1.11780244280729 0.9375 5.2 5 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 7.02746300719406e-05 0.000269543931515826 1.11780244280729 0.9375 5.2 5 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 7.02746300719406e-05 0.000269543931515826 1.11780244280729 0.9375 5.2 5 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000144982370135212 0.000533100549618621 1.11283443195037 0.933333333333333 5.2 5 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000144982370135212 0.000533100549618621 1.11283443195037 0.933333333333333 5.2 5 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000144982370135212 0.000533100549618621 1.11283443195037 0.933333333333333 5.2 5 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.13356314499081e-11 2.4075527691372e-10 1.11283443195037 0.933333333333333 5.2 5 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.32589588992779e-11 4.66161950896795e-10 1.11102788254785 0.931818181818182 5.2 5 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 1.61263942587571e-07 1.18900823990733e-06 1.10715670525674 0.928571428571429 5.2 5 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000297907823897481 0.00100934007953837 1.10715670525674 0.928571428571429 5.2 5 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.000297907823897481 0.00100934007953837 1.10715670525674 0.928571428571429 5.2 5 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.98952805021942e-10 3.42751162348627e-09 1.10507948817371 0.926829268292683 5.2 5 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.98952805021942e-10 3.42751162348627e-09 1.10507948817371 0.926829268292683 5.2 5 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 3.29341249634947e-07 2.231679039193e-06 1.10400241264917 0.925925925925926 5.2 5 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 3.29341249634947e-07 2.231679039193e-06 1.10400241264917 0.925925925925926 5.2 5 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.000609335507351946 0.00193545631018263 1.10060548214872 0.923076923076923 5.2 5 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000609335507351946 0.00193545631018263 1.10060548214872 0.923076923076923 5.2 5 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000609335507351946 0.00193545631018263 1.10060548214872 0.923076923076923 5.2 5 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 8.84223637979531e-12 1.93576959514596e-10 1.09499014805612 0.918367346938776 5.2 5 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 6.85316313711873e-09 7.2776501075522e-08 1.09296238852268 0.916666666666667 5.2 5 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 2.75786253516572e-06 1.33031809747147e-05 1.09296238852268 0.916666666666667 5.2 5 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 2.75786253516572e-06 1.33031809747147e-05 1.09296238852268 0.916666666666667 5.2 5 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 2.75786253516572e-06 1.33031809747147e-05 1.09296238852268 0.916666666666667 5.2 5 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 2.75786253516572e-06 1.33031809747147e-05 1.09296238852268 0.916666666666667 5.2 5 2 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.00123977287935903 0.00360040164760797 1.09296238852268 0.916666666666667 5.2 5 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00123977287935903 0.00360040164760797 1.09296238852268 0.916666666666667 5.2 5 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00123977287935903 0.00360040164760797 1.09296238852268 0.916666666666667 5.2 5 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00123977287935903 0.00360040164760797 1.09296238852268 0.916666666666667 5.2 5 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0025070889777949 0.00669341016022916 1.0839296415101 0.909090909090909 5.2 5 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0025070889777949 0.00669341016022916 1.0839296415101 0.909090909090909 5.2 5 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0025070889777949 0.00669341016022916 1.0839296415101 0.909090909090909 5.2 5 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0025070889777949 0.00669341016022916 1.0839296415101 0.909090909090909 5.2 5 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0025070889777949 0.00669341016022916 1.0839296415101 0.909090909090909 5.2 5 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.23950467182461e-05 9.34549896776078e-05 1.07876807178862 0.904761904761905 5.2 5 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.42227545813426e-07 2.66648219361231e-06 1.073090345095 0.9 5.2 5 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 4.46416567005802e-05 0.000175483639461121 1.073090345095 0.9 5.2 5 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 4.46416567005802e-05 0.000175483639461121 1.073090345095 0.9 5.2 5 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 4.46416567005802e-05 0.000175483639461121 1.073090345095 0.9 5.2 5 2 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.00503352643752834 0.012413705581634 1.073090345095 0.9 5.2 5 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00503352643752834 0.012413705581634 1.073090345095 0.9 5.2 5 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00503352643752834 0.012413705581634 1.073090345095 0.9 5.2 5 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00503352643752834 0.012413705581634 1.073090345095 0.9 5.2 5 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.00503352643752834 0.012413705581634 1.073090345095 0.9 5.2 5 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.76250340826265e-07 4.87071966795224e-06 1.0689788878341 0.896551724137931 5.2 5 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 8.85585977859754e-05 0.000333383292723394 1.06681496295994 0.894736842105263 5.2 5 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 1.72998547502972e-06 8.79203332488321e-06 1.06457375505456 0.892857142857143 5.2 5 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 3.40232748317584e-06 1.61383733618641e-05 1.05984231614321 0.888888888888889 5.2 5 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000174744820853933 0.000629523747025687 1.05984231614321 0.888888888888889 5.2 5 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0100195241103888 0.0228490109119924 1.05984231614321 0.888888888888889 5.2 5 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0100195241103888 0.0228490109119924 1.05984231614321 0.888888888888889 5.2 5 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0100195241103888 0.0228490109119924 1.05984231614321 0.888888888888889 5.2 5 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0100195241103888 0.0228490109119924 1.05984231614321 0.888888888888889 5.2 5 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0100195241103888 0.0228490109119924 1.05984231614321 0.888888888888889 5.2 5 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 6.66352608521548e-06 3.05877342556827e-05 1.05474692039252 0.884615384615385 5.2 5 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 6.66352608521548e-06 3.05877342556827e-05 1.05474692039252 0.884615384615385 5.2 5 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 6.66352608521548e-06 3.05877342556827e-05 1.05474692039252 0.884615384615385 5.2 5 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 6.66352608521548e-06 3.05877342556827e-05 1.05474692039252 0.884615384615385 5.2 5 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000342772367804198 0.00113963803594714 1.05204935793627 0.882352941176471 5.2 5 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.000342772367804198 0.00113963803594714 1.05204935793627 0.882352941176471 5.2 5 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.000342772367804198 0.00113963803594714 1.05204935793627 0.882352941176471 5.2 5 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000342772367804198 0.00113963803594714 1.05204935793627 0.882352941176471 5.2 5 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.08421533494697e-08 1.07890798715352e-07 1.0503794383205 0.880952380952381 5.2 5 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.29923222950032e-05 5.72386211324753e-05 1.04924389298178 0.88 5.2 5 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.29923222950032e-05 5.72386211324753e-05 1.04924389298178 0.88 5.2 5 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.26705937393243e-13 4.00672330912412e-12 1.04328227995347 0.875 5.2 5 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.52096962152596e-05 0.000104283132890449 1.04328227995347 0.875 5.2 5 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000667936550578112 0.00207527011238571 1.04328227995347 0.875 5.2 5 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000667936550578112 0.00207527011238571 1.04328227995347 0.875 5.2 5 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.000667936550578112 0.00207527011238571 1.04328227995347 0.875 5.2 5 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000667936550578112 0.00207527011238571 1.04328227995347 0.875 5.2 5 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000667936550578112 0.00207527011238571 1.04328227995347 0.875 5.2 5 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.000667936550578112 0.00207527011238571 1.04328227995347 0.875 5.2 5 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.0197377118549094 0.0405318748398333 1.04328227995347 0.875 5.2 5 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.10327348501433e-11 2.37872449875059e-10 1.03847452751129 0.870967741935484 5.2 5 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 1.92584945618658e-06 9.58211110543181e-06 1.03847452751129 0.870967741935484 5.2 5 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.92584945618658e-06 9.58211110543181e-06 1.03847452751129 0.870967741935484 5.2 5 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 6.23143870356579e-09 6.76895975204131e-08 1.03680226579227 0.869565217391304 5.2 5 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 4.86597967659004e-05 0.000189706550131168 1.03680226579227 0.869565217391304 5.2 5 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 4.86597967659004e-05 0.000189706550131168 1.03680226579227 0.869565217391304 5.2 5 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.19329875806603e-08 1.16305762515614e-07 1.03334625823963 0.866666666666667 5.2 5 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00129192327335223 0.00372901991476719 1.03334625823963 0.866666666666667 5.2 5 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00129192327335223 0.00372901991476719 1.03334625823963 0.866666666666667 5.2 5 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00129192327335223 0.00372901991476719 1.03334625823963 0.866666666666667 5.2 5 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 5.48734716336765e-07 3.20020287437384e-06 1.02672224376373 0.861111111111111 5.2 5 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 5.48734716336765e-07 3.20020287437384e-06 1.02672224376373 0.861111111111111 5.2 5 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.26092338804733e-11 4.59613425884479e-10 1.02465223924002 0.859375 5.2 5 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.27979216992249e-10 6.42149081863223e-09 1.02199080485238 0.857142857142857 5.2 5 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 1.04155865747018e-06 5.67868953862096e-06 1.02199080485238 0.857142857142857 5.2 5 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 1.34363795320525e-05 5.88306709972639e-05 1.02199080485238 0.857142857142857 5.2 5 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.34363795320525e-05 5.88306709972639e-05 1.02199080485238 0.857142857142857 5.2 5 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000178121316594585 0.000633666583785235 1.02199080485238 0.857142857142857 5.2 5 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.000178121316594585 0.000633666583785235 1.02199080485238 0.857142857142857 5.2 5 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000178121316594585 0.000633666583785235 1.02199080485238 0.857142857142857 5.2 5 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00247790160807874 0.00667813255359099 1.02199080485238 0.857142857142857 5.2 5 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00247790160807874 0.00667813255359099 1.02199080485238 0.857142857142857 5.2 5 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00247790160807874 0.00667813255359099 1.02199080485238 0.857142857142857 5.2 5 2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0383827725350405 0.0721514997587353 1.02199080485238 0.857142857142857 5.2 5 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.23821711430635e-08 1.18253889507244e-07 1.01844222566886 0.854166666666667 5.2 5 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.55176468639548e-07 1.15008393163582e-06 1.01783637068631 0.853658536585366 5.2 5 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.55176468639548e-07 1.15008393163582e-06 1.01783637068631 0.853658536585366 5.2 5 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.55176468639548e-07 1.15008393163582e-06 1.01783637068631 0.853658536585366 5.2 5 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.55176468639548e-07 1.15008393163582e-06 1.01783637068631 0.853658536585366 5.2 5 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 2.54154180469435e-05 0.000104526415840464 1.01568221963724 0.851851851851852 5.2 5 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 2.54154180469435e-05 0.000104526415840464 1.01568221963724 0.851851851851852 5.2 5 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.33017528485476e-08 2.11199963716453e-07 1.01474264311584 0.851063829787234 5.2 5 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.9257228413381e-13 8.16334039847865e-12 1.01347421481194 0.85 5.2 5 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.85391544781027e-10 3.72579970847157e-09 1.01347421481194 0.85 5.2 5 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.85391544781027e-10 3.72579970847157e-09 1.01347421481194 0.85 5.2 5 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.85391544781027e-10 3.72579970847157e-09 1.01347421481194 0.85 5.2 5 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.85391544781027e-10 3.72579970847157e-09 1.01347421481194 0.85 5.2 5 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.85391544781027e-10 3.72579970847157e-09 1.01347421481194 0.85 5.2 5 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.85391544781027e-10 3.72579970847157e-09 1.01347421481194 0.85 5.2 5 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.85391544781027e-10 3.72579970847157e-09 1.01347421481194 0.85 5.2 5 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000337421263936547 0.00113243032684365 1.01347421481194 0.85 5.2 5 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.000337421263936547 0.00113243032684365 1.01347421481194 0.85 5.2 5 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.000337421263936547 0.00113243032684365 1.01347421481194 0.85 5.2 5 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3.70298686262659e-06 1.7390595067715e-05 1.01166766540943 0.848484848484849 5.2 5 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 3.70298686262659e-06 1.7390595067715e-05 1.01166766540943 0.848484848484849 5.2 5 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 4.78007014488353e-05 0.00018738401697436 1.00888835863632 0.846153846153846 5.2 5 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00470717842539801 0.0117308492107554 1.00888835863632 0.846153846153846 5.2 5 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.00470717842539801 0.0117308492107554 1.00888835863632 0.846153846153846 5.2 5 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00470717842539801 0.0117308492107554 1.00888835863632 0.846153846153846 5.2 5 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00470717842539801 0.0117308492107554 1.00888835863632 0.846153846153846 5.2 5 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00470717842539801 0.0117308492107554 1.00888835863632 0.846153846153846 5.2 5 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00470717842539801 0.0117308492107554 1.00888835863632 0.846153846153846 5.2 5 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 6.93203706142097e-06 3.17179702199423e-05 1.00602219852656 0.84375 5.2 5 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.22766431540486e-08 1.18038264920346e-07 1.00529160869466 0.843137254901961 5.2 5 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.22766431540486e-08 1.18038264920346e-07 1.00529160869466 0.843137254901961 5.2 5 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.000634404677216375 0.00199725189309492 1.00406114160936 0.842105263157895 5.2 5 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000634404677216375 0.00199725189309492 1.00406114160936 0.842105263157895 5.2 5 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.51991446473904e-07 1.15008393163582e-06 1.00263491839684 0.840909090909091 5.2 5 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.51991446473904e-07 1.15008393163582e-06 1.00263491839684 0.840909090909091 5.2 5 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 8.93509092966057e-05 0.000335478480023931 1.00155098875533 0.84 5.2 5 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 1.29094535799702e-05 5.72278892345718e-05 1.00001250797383 0.838709677419355 5.2 5 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 1.89632199446434e-06 9.50164154268577e-06 0.99897299393228 0.837837837837838 5.2 5 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 1.89632199446434e-06 9.50164154268577e-06 0.99897299393228 0.837837837837838 5.2 5 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 5.26965314316952e-13 1.33905650405897e-11 0.995940058846338 0.835294117647059 5.2 5 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00118291010255553 0.00347068263079694 0.993602171384258 0.833333333333333 5.2 5 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00118291010255553 0.00347068263079694 0.993602171384258 0.833333333333333 5.2 5 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.17413769130056e-08 1.15227443773842e-07 0.993602171384257 0.833333333333333 5.2 5 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 5.20286456141923e-07 3.05937035987585e-06 0.993602171384257 0.833333333333333 5.2 5 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.00884366946997425 0.0208698866596573 0.993602171384257 0.833333333333333 5.2 5 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00884366946997425 0.0208698866596573 0.993602171384257 0.833333333333333 5.2 5 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00884366946997425 0.0208698866596573 0.993602171384257 0.833333333333333 5.2 5 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.00884366946997425 0.0208698866596573 0.993602171384257 0.833333333333333 5.2 5 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00884366946997425 0.0208698866596573 0.993602171384257 0.833333333333333 5.2 5 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605630 MULTIFUNCTIONAL ANION EXCHANGERS 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.0734234265483946 0.122343718944222 0.993602171384257 0.833333333333333 5.2 5 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 4.96874048629927e-10 6.1482762713077e-09 0.990544933933844 0.830769230769231 5.2 5 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 1.43134169251748e-07 1.11300504287015e-06 0.989374077037941 0.829787234042553 5.2 5 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 7.02917343391479e-31 9.09319436041886e-29 0.989146556265942 0.829596412556054 5.2 5 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 9.56408444451907e-07 5.23449698636563e-06 0.988755331523847 0.829268292682927 5.2 5 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 9.56408444451907e-07 5.23449698636563e-06 0.988755331523847 0.829268292682927 5.2 5 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 9.56408444451907e-07 5.23449698636563e-06 0.988755331523847 0.829268292682927 5.2 5 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 9.56408444451907e-07 5.23449698636563e-06 0.988755331523847 0.829268292682927 5.2 5 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 6.44826326772284e-06 2.99865314704889e-05 0.987924444690633 0.828571428571429 5.2 5 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 4.40150169796582e-05 0.000174466209365052 0.98674974261609 0.827586206896552 5.2 5 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 4.40150169796582e-05 0.000174466209365052 0.98674974261609 0.827586206896552 5.2 5 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.53456493642702e-10 3.53596657307417e-09 0.984962152502655 0.826086956521739 5.2 5 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 2.61933587452096e-07 1.79197834107852e-06 0.984962152502655 0.826086956521739 5.2 5 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.61933587452096e-07 1.79197834107852e-06 0.984962152502655 0.826086956521739 5.2 5 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000305852245412706 0.00103379511929283 0.984962152502655 0.826086956521739 5.2 5 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.72249336393235e-15 7.20769571327841e-14 0.984486555133026 0.825688073394495 5.2 5 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.75002272953843e-06 8.83078845437299e-06 0.983666149670415 0.825 5.2 5 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.75002272953843e-06 8.83078845437299e-06 0.983666149670415 0.825 5.2 5 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 1.17976214651544e-05 5.26270073508297e-05 0.981912734073854 0.823529411764706 5.2 5 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.17976214651544e-05 5.26270073508297e-05 0.981912734073854 0.823529411764706 5.2 5 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.17976214651544e-05 5.26270073508297e-05 0.981912734073854 0.823529411764706 5.2 5 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00218536940352304 0.00592339173564434 0.981912734073854 0.823529411764706 5.2 5 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00218536940352304 0.00592339173564434 0.981912734073854 0.823529411764706 5.2 5 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 8.373625241756e-10 9.84766009836263e-09 0.978772288229269 0.82089552238806 5.2 5 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.30708209620986e-07 1.02761205685449e-06 0.977704536642109 0.82 5.2 5 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.2205467421322e-15 1.9549573721195e-13 0.975536677359089 0.818181818181818 5.2 5 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 2.14627629559956e-05 8.98279755481815e-05 0.975536677359089 0.818181818181818 5.2 5 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 8.65927112901615e-07 4.83221286925097e-06 0.975536677359089 0.818181818181818 5.2 5 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.000559417109056601 0.00178887763188212 0.975536677359089 0.818181818181818 5.2 5 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000559417109056601 0.00178887763188212 0.975536677359089 0.818181818181818 5.2 5 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000559417109056601 0.00178887763188212 0.975536677359089 0.818181818181818 5.2 5 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000559417109056601 0.00178887763188212 0.975536677359089 0.818181818181818 5.2 5 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0164024950063289 0.0356892207859419 0.975536677359089 0.818181818181818 5.2 5 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.73238388843921e-09 3.1105458185992e-08 0.972201509231366 0.815384615384615 5.2 5 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00014629594841716 0.000535164870430896 0.971522123131274 0.814814814814815 5.2 5 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00014629594841716 0.000535164870430896 0.971522123131274 0.814814814814815 5.2 5 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 7.5605142496425e-10 9.00809532052082e-09 0.97089126460976 0.814285714285714 5.2 5 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.56367375241746e-06 8.08444528272934e-06 0.970495144142763 0.813953488372093 5.2 5 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.56367375241746e-06 8.08444528272934e-06 0.970495144142763 0.813953488372093 5.2 5 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 1.56367375241746e-06 8.08444528272934e-06 0.970495144142763 0.813953488372093 5.2 5 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.0955271345278e-10 3.42751162348627e-09 0.969755719271035 0.813333333333333 5.2 5 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.0955271345278e-10 3.42751162348627e-09 0.969755719271035 0.813333333333333 5.2 5 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.0955271345278e-10 3.42751162348627e-09 0.969755719271035 0.813333333333333 5.2 5 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.0955271345278e-10 3.42751162348627e-09 0.969755719271035 0.813333333333333 5.2 5 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.0955271345278e-10 3.42751162348627e-09 0.969755719271035 0.813333333333333 5.2 5 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00399586573870673 0.0103383944475994 0.968762117099651 0.8125 5.2 5 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00399586573870673 0.0103383944475994 0.968762117099651 0.8125 5.2 5 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00399586573870673 0.0103383944475994 0.968762117099651 0.8125 5.2 5 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00399586573870673 0.0103383944475994 0.968762117099651 0.8125 5.2 5 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 1.04029199431642e-05 4.68460603769705e-05 0.966748058644142 0.810810810810811 5.2 5 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.49065254444026e-13 9.51828098174138e-12 0.965781310585498 0.81 5.2 5 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.79901003881757e-09 9.20661123914515e-08 0.965213537916136 0.80952380952381 5.2 5 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00101444604013988 0.00300115741188992 0.965213537916136 0.80952380952381 5.2 5 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00101444604013988 0.00300115741188992 0.965213537916136 0.80952380952381 5.2 5 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00101444604013988 0.00300115741188992 0.965213537916136 0.80952380952381 5.2 5 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.37647591679449e-33 6.86389318514079e-31 0.96437857810825 0.808823529411765 5.2 5 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.08457504480265e-07 1.46849024195751e-06 0.963029796880127 0.807692307692308 5.2 5 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 2.08457504480265e-07 1.46849024195751e-06 0.963029796880127 0.807692307692308 5.2 5 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.08457504480265e-07 1.46849024195751e-06 0.963029796880127 0.807692307692308 5.2 5 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.000263861782257239 0.00090042042242698 0.963029796880127 0.807692307692308 5.2 5 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000263861782257239 0.00090042042242698 0.963029796880127 0.807692307692308 5.2 5 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000263861782257239 0.00090042042242698 0.963029796880127 0.807692307692308 5.2 5 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.000263861782257239 0.00090042042242698 0.963029796880127 0.807692307692308 5.2 5 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 6.97352139273809e-05 0.000269543931515826 0.961550488436378 0.806451612903226 5.2 5 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.86389721581487e-05 7.87040278369307e-05 0.960482099004782 0.805555555555556 5.2 5 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.86389721581487e-05 7.87040278369307e-05 0.960482099004782 0.805555555555556 5.2 5 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 1.36273825021811e-06 7.2088346842393e-06 0.959042095857849 0.804347826086957 5.2 5 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.36273825021811e-06 7.2088346842393e-06 0.959042095857849 0.804347826086957 5.2 5 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.36273825021811e-06 7.2088346842393e-06 0.959042095857849 0.804347826086957 5.2 5 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.71540046266449e-07 2.25521180929982e-06 0.958533859453048 0.803921568627451 5.2 5 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.52993808085029e-13 4.53562893552075e-12 0.958315365297714 0.803738317757009 5.2 5 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 4.95052817440859e-08 4.34851950134779e-07 0.953858084528887 0.8 5.2 5 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 8.93333182473141e-06 4.0613837656846e-05 0.953858084528887 0.8 5.2 5 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00182233833033569 0.00507473081030859 0.953858084528887 0.8 5.2 5 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00182233833033569 0.00507473081030859 0.953858084528887 0.8 5.2 5 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00182233833033569 0.00507473081030859 0.953858084528887 0.8 5.2 5 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00182233833033569 0.00507473081030859 0.953858084528887 0.8 5.2 5 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00182233833033569 0.00507473081030859 0.953858084528887 0.8 5.2 5 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00182233833033569 0.00507473081030859 0.953858084528887 0.8 5.2 5 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00722181494698476 0.0173299201847543 0.953858084528887 0.8 5.2 5 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00722181494698476 0.0173299201847543 0.953858084528887 0.8 5.2 5 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00722181494698476 0.0173299201847543 0.953858084528887 0.8 5.2 5 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00722181494698476 0.0173299201847543 0.953858084528887 0.8 5.2 5 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00722181494698476 0.0173299201847543 0.953858084528887 0.8 5.2 5 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00722181494698476 0.0173299201847543 0.953858084528887 0.8 5.2 5 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0299635148018308 0.0578535706417981 0.953858084528887 0.8 5.2 5 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 3.76109188052772e-09 4.18127636405543e-08 0.953858084528887 0.8 5.2 5 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 4.7892183774449e-13 1.23910140929165e-11 0.953858084528887 0.8 5.2 5 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.07219544247611e-21 1.84295882165219e-19 0.951251914899027 0.797814207650273 5.2 5 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 5.08163789684184e-10 6.23376786828099e-09 0.950839546286707 0.79746835443038 5.2 5 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 2.40493842069388e-08 2.16596669154898e-07 0.950132076386196 0.796875 5.2 5 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 8.73789110679767e-08 7.10515373998462e-07 0.949816312984273 0.796610169491525 5.2 5 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 8.73789110679767e-08 7.10515373998462e-07 0.949816312984273 0.796610169491525 5.2 5 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.43215642045251e-19 1.01897929315196e-17 0.946844422142645 0.794117647058823 5.2 5 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.53604254688775e-07 1.15008393163582e-06 0.945635170007087 0.793103448275862 5.2 5 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 1.53604254688775e-07 1.15008393163582e-06 0.945635170007087 0.793103448275862 5.2 5 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.50756218464368e-19 1.62193681306725e-17 0.945391888512359 0.792899408284024 5.2 5 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 5.59716654177739e-07 3.25092570977519e-06 0.944859423354086 0.792452830188679 5.2 5 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000837631639808393 0.00252678712949955 0.943922062815045 0.791666666666667 5.2 5 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000837631639808393 0.00252678712949955 0.943922062815045 0.791666666666667 5.2 5 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000837631639808393 0.00252678712949955 0.943922062815045 0.791666666666667 5.2 5 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.04361457538113e-08 1.86414329536369e-07 0.943180568657295 0.791044776119403 5.2 5 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.04361457538113e-08 1.86414329536369e-07 0.943180568657295 0.791044776119403 5.2 5 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 7.40386444794414e-08 6.38527218753001e-07 0.942319478667651 0.790322580645161 5.2 5 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 7.59642613114897e-10 9.00809532052082e-09 0.942082058793963 0.790123456790123 5.2 5 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 7.59642613114897e-10 9.00809532052082e-09 0.942082058793963 0.790123456790123 5.2 5 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00323980544757735 0.0085374873183381 0.94130732025877 0.789473684210526 5.2 5 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00323980544757735 0.0085374873183381 0.94130732025877 0.789473684210526 5.2 5 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00323980544757735 0.0085374873183381 0.94130732025877 0.789473684210526 5.2 5 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.93305173091978e-28 2.15837333173438e-26 0.941066884161642 0.789272030651341 5.2 5 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.68148304008388e-10 4.76250033276306e-09 0.939830759756403 0.788235294117647 5.2 5 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.38745230256631e-11 2.8613690239882e-10 0.939405689308752 0.787878787878788 5.2 5 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.29137359318592e-07 1.02576187588354e-06 0.938221066749725 0.786885245901639 5.2 5 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.29137359318592e-07 1.02576187588354e-06 0.938221066749725 0.786885245901639 5.2 5 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.43562623118996e-17 7.85729279608968e-16 0.937360539041752 0.786163522012579 5.2 5 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 4.68660465562731e-07 2.80211698527633e-06 0.936824904448014 0.785714285714286 5.2 5 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000387478110156792 0.0012763902010631 0.936824904448014 0.785714285714286 5.2 5 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0128811934222353 0.0290490304910314 0.936824904448014 0.785714285714286 5.2 5 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0128811934222353 0.0290490304910314 0.936824904448014 0.785714285714286 5.2 5 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 6.99017218710453e-18 3.9788060088999e-16 0.936302414261484 0.785276073619632 5.2 5 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.30566836936145e-17 2.26924669985235e-15 0.934112614626219 0.78343949044586 5.2 5 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.24306647854353e-07 1.54945805775118e-06 0.933986041101202 0.783333333333333 5.2 5 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.53159177247866e-16 7.26485030745709e-15 0.933463092589947 0.782894736842105 5.2 5 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00147225061817462 0.00421666794050813 0.933122039213042 0.782608695652174 5.2 5 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00147225061817462 0.00421666794050813 0.933122039213042 0.782608695652174 5.2 5 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 8.13160105727576e-07 4.55561744271787e-06 0.932179491698685 0.781818181818182 5.2 5 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 8.13160105727576e-07 4.55561744271787e-06 0.932179491698685 0.781818181818182 5.2 5 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 8.13160105727576e-07 4.55561744271787e-06 0.932179491698685 0.781818181818182 5.2 5 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.89761368535151e-19 1.28585917821676e-17 0.931705642675074 0.781420765027322 5.2 5 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 2.28343102041485e-05 9.50094252061501e-05 0.930593253198914 0.780487804878049 5.2 5 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.44969707861564e-14 8.29980700683345e-13 0.930372942296168 0.78030303030303 5.2 5 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 5.14242787195035e-08 4.48937108084991e-07 0.929310266177041 0.779411764705882 5.2 5 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 9.21744436870085e-10 1.07511666693945e-08 0.928902495108073 0.779069767441861 5.2 5 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.80065870234472e-37 5.12467466687306e-35 0.927716251998349 0.77807486631016 5.2 5 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.43570270285042e-10 5.63571870192513e-09 0.927362026625307 0.777777777777778 5.2 5 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.85197955077799e-07 1.33099338422075e-06 0.927362026625307 0.777777777777778 5.2 5 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.85197955077799e-07 1.33099338422075e-06 0.927362026625307 0.777777777777778 5.2 5 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 8.4141341593443e-05 0.000317594506863314 0.927362026625307 0.777777777777778 5.2 5 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000675342200697519 0.00208462462384505 0.927362026625307 0.777777777777778 5.2 5 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000675342200697519 0.00208462462384505 0.927362026625307 0.777777777777778 5.2 5 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000675342200697519 0.00208462462384505 0.927362026625307 0.777777777777778 5.2 5 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00569397695690934 0.0138741938521952 0.927362026625307 0.777777777777778 5.2 5 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00569397695690934 0.0138741938521952 0.927362026625307 0.777777777777778 5.2 5 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00569397695690934 0.0138741938521952 0.927362026625307 0.777777777777778 5.2 5 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00569397695690934 0.0138741938521952 0.927362026625307 0.777777777777778 5.2 5 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00569397695690934 0.0138741938521952 0.927362026625307 0.777777777777778 5.2 5 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00569397695690934 0.0138741938521952 0.927362026625307 0.777777777777778 5.2 5 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00569397695690934 0.0138741938521952 0.927362026625307 0.777777777777778 5.2 5 2 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0537513689607317 0.0941972882156665 0.927362026625307 0.777777777777778 5.2 5 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 9.85734171247875e-15 3.59666596329673e-13 0.926408931017264 0.776978417266187 5.2 5 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.23919437428692e-13 4.00672330912412e-12 0.924281089659774 0.775193798449612 5.2 5 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 2.41328787303449e-06 1.18417539425106e-05 0.922362770417084 0.773584905660377 5.2 5 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.02218195205265e-08 1.86414329536369e-07 0.922062815044591 0.773333333333333 5.2 5 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00256154440582305 0.00682598818255842 0.921340195283584 0.772727272727273 5.2 5 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.63879061163116e-41 2.00599976008778e-38 0.920831308127946 0.772300469483568 5.2 5 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 9.67578304822027e-09 9.83474234115531e-08 0.920654163864907 0.772151898734177 5.2 5 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 9.67578304822027e-09 9.83474234115531e-08 0.920654163864907 0.772151898734177 5.2 5 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.61199699939588e-13 9.51828098174138e-12 0.920059963423533 0.771653543307087 5.2 5 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.61199699939588e-13 9.51828098174138e-12 0.920059963423533 0.771653543307087 5.2 5 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.37447586893081e-14 8.24116868655743e-13 0.919791724367141 0.771428571428571 5.2 5 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.37447586893081e-14 8.24116868655743e-13 0.919791724367141 0.771428571428571 5.2 5 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.97180979005952e-28 2.15837333173438e-26 0.919675456926316 0.771331058020478 5.2 5 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.27677576306428e-12 3.18745949270257e-11 0.918674794525772 0.770491803278688 5.2 5 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.43819398503795e-10 2.55818755088626e-09 0.918088406359054 0.77 5.2 5 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00116643478758198 0.00344364461147127 0.91717123512393 0.769230769230769 5.2 5 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.022631972951895 0.0455520473982271 0.91717123512393 0.769230769230769 5.2 5 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.022631972951895 0.0455520473982271 0.91717123512393 0.769230769230769 5.2 5 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.022631972951895 0.0455520473982271 0.91717123512393 0.769230769230769 5.2 5 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.022631972951895 0.0455520473982271 0.91717123512393 0.769230769230769 5.2 5 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.022631972951895 0.0455520473982271 0.91717123512393 0.769230769230769 5.2 5 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.64870854199205e-08 1.55371672533423e-07 0.91717123512393 0.769230769230769 5.2 5 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 6.18039838740582e-16 2.74834590789952e-14 0.916598003101978 0.76875 5.2 5 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.73792199202986e-21 2.29180176156382e-19 0.915920547076034 0.768181818181818 5.2 5 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 6.91741673789087e-17 3.51553000643525e-15 0.915038278763177 0.767441860465116 5.2 5 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 3.16959832525171e-05 0.000129263147827279 0.915038278763177 0.767441860465116 5.2 5 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.000535905040323925 0.00174906622105722 0.914113997673517 0.766666666666667 5.2 5 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.38278561330246e-20 2.67427995984967e-18 0.914113997673517 0.766666666666667 5.2 5 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.77279936728562e-15 7.20769571327841e-14 0.913107818259457 0.765822784810127 5.2 5 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.84612590274403e-24 1.8764551140034e-22 0.91258537894831 0.765384615384615 5.2 5 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.13624090883838e-10 5.30258631826758e-09 0.912491790046767 0.76530612244898 5.2 5 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00987997882805376 0.0227127784690154 0.911776110211436 0.764705882352941 5.2 5 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00987997882805376 0.0227127784690154 0.911776110211436 0.764705882352941 5.2 5 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00987997882805376 0.0227127784690154 0.911776110211436 0.764705882352941 5.2 5 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00987997882805376 0.0227127784690154 0.911776110211436 0.764705882352941 5.2 5 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 6.38297570040144e-09 6.82930407644454e-08 0.911776110211436 0.764705882352941 5.2 5 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 6.38297570040144e-09 6.82930407644454e-08 0.911776110211436 0.764705882352941 5.2 5 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 3.31404691160519e-06 1.57722031946963e-05 0.910500898868483 0.763636363636364 5.2 5 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.31404691160519e-06 1.57722031946963e-05 0.910500898868483 0.763636363636364 5.2 5 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 3.31404691160519e-06 1.57722031946963e-05 0.910500898868483 0.763636363636364 5.2 5 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000115292315741151 0.000429478966753032 0.909930409583478 0.763157894736842 5.2 5 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.56803014619346e-06 8.08444528272934e-06 0.909398597538134 0.76271186440678 5.2 5 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.59034913425439e-13 4.61850371029386e-12 0.9092532100725 0.762589928057554 5.2 5 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.52744460450501e-07 2.25521180929982e-06 0.907588849085322 0.761194029850746 5.2 5 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.6764981403949e-07 1.22972002772265e-06 0.906836911347886 0.76056338028169 5.2 5 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.18703055645133e-05 5.2785765057195e-05 0.906165180302443 0.76 5.2 5 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00199499694123947 0.00543846867314898 0.906165180302443 0.76 5.2 5 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00199499694123947 0.00543846867314898 0.906165180302443 0.76 5.2 5 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00199499694123947 0.00543846867314898 0.906165180302443 0.76 5.2 5 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00199499694123947 0.00543846867314898 0.906165180302443 0.76 5.2 5 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00199499694123947 0.00543846867314898 0.906165180302443 0.76 5.2 5 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00199499694123947 0.00543846867314898 0.906165180302443 0.76 5.2 5 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 5.59554724050912e-06 2.61923148790937e-05 0.905281978372323 0.759259259259259 5.2 5 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.81149593139893e-08 1.69589388840834e-07 0.905015953694577 0.759036144578313 5.2 5 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.000912420733608034 0.0027162650709712 0.904520597398083 0.758620689655172 5.2 5 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 5.41176301473104e-46 2.56697958998742e-43 0.904442432811374 0.758555133079848 5.2 5 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 6.80268784354751e-12 1.51253512521377e-10 0.903857459130195 0.758064516129032 5.2 5 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 6.80268784354751e-12 1.51253512521377e-10 0.903857459130195 0.758064516129032 5.2 5 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 6.80268784354751e-12 1.51253512521377e-10 0.903857459130195 0.758064516129032 5.2 5 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.25117330486678e-06 6.74401368494482e-06 0.903857459130195 0.758064516129032 5.2 5 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.37281509507125e-11 4.68960538928666e-10 0.901756592516805 0.756302521008403 5.2 5 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.03531347934245e-08 2.71651011390208e-07 0.901512214036448 0.75609756097561 5.2 5 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.44730881629366e-08 1.37301363039058e-07 0.90117406241828 0.755813953488372 5.2 5 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 9.396980178058e-06 4.25856776859125e-05 0.899866117480082 0.754716981132076 5.2 5 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 8.2635688906446e-11 1.48848842169459e-09 0.89947143935838 0.754385964912281 5.2 5 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 2.09641322719252e-06 1.03944112275085e-05 0.89912852230182 0.754098360655738 5.2 5 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 4.36064972988422e-12 1.0172466501025e-10 0.898827810421451 0.753846153846154 5.2 5 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.71049466284477e-07 2.80461669674816e-06 0.898561963686633 0.753623188405797 5.2 5 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.23764250022459e-07 1.54945805775118e-06 0.898325250840561 0.753424657534247 5.2 5 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 2.23764250022459e-07 1.54945805775118e-06 0.898325250840561 0.753424657534247 5.2 5 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.24379692517561e-19 9.31538433960467e-18 0.898252007852315 0.753363228699552 5.2 5 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.15182511156179e-08 1.13822717621696e-07 0.89759117504825 0.752808988764045 5.2 5 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.86223684409754e-18 1.15215783876122e-16 0.897080817592644 0.752380952380952 5.2 5 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.15566005398772e-11 6.06824899570882e-10 0.896705430703809 0.752066115702479 5.2 5 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.15566005398772e-11 6.06824899570882e-10 0.896705430703809 0.752066115702479 5.2 5 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.0867840926454e-15 4.68634473889212e-14 0.895926025722754 0.751412429378531 5.2 5 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 2.03193846268524e-21 1.84295882165219e-19 0.895439065295692 0.751004016064257 5.2 5 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.77053018956337e-07 1.29203305628138e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.7243483849997e-07 2.25521180929982e-06 0.894241954245832 0.75 5.2 5 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.000152334137897728 0.000555824303149917 0.894241954245832 0.75 5.2 5 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0033761075532733 0.00888022374918283 0.894241954245832 0.75 5.2 5 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0390789716153928 0.0722199696216935 0.894241954245832 0.75 5.2 5 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.28242025757474e-10 3.53596657307417e-09 0.894241954245832 0.75 5.2 5 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 1.65448961107297e-06 8.49941774930265e-06 0.894241954245832 0.75 5.2 5 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000707522410191525 0.0021745235198759 0.894241954245832 0.75 5.2 5 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.000707522410191525 0.0021745235198759 0.894241954245832 0.75 5.2 5 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00153893447231969 0.00438858467757698 0.894241954245832 0.75 5.2 5 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00153893447231969 0.00438858467757698 0.894241954245832 0.75 5.2 5 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0168996625718188 0.0363266160720516 0.894241954245832 0.75 5.2 5 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0168996625718188 0.0363266160720516 0.894241954245832 0.75 5.2 5 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0168996625718188 0.0363266160720516 0.894241954245832 0.75 5.2 5 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0168996625718188 0.0363266160720516 0.894241954245832 0.75 5.2 5 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0168996625718188 0.0363266160720516 0.894241954245832 0.75 5.2 5 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0168996625718188 0.0363266160720516 0.894241954245832 0.75 5.2 5 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0168996625718188 0.0363266160720516 0.894241954245832 0.75 5.2 5 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0943179545754335 0.150708486525493 0.894241954245832 0.75 5.2 5 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 4.15125200052308e-11 7.87630879565912e-10 0.891818534315626 0.747967479674797 5.2 5 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.45062476980149e-09 3.89701511700596e-08 0.89123103857497 0.747474747474748 5.2 5 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.39581622813848e-07 1.09134422672586e-06 0.890468781443107 0.746835443037975 5.2 5 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 6.17204799647469e-07 3.53728558132988e-06 0.890043635211814 0.746478873239437 5.2 5 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.09686872064228e-07 8.81832875409017e-07 0.886971694455215 0.74390243902439 5.2 5 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.2022450698533e-13 3.97859240558429e-12 0.88678993796045 0.74375 5.2 5 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.83964189114047e-07 2.85759768095141e-06 0.886185720423797 0.743243243243243 5.2 5 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.83964189114047e-07 2.85759768095141e-06 0.886185720423797 0.743243243243243 5.2 5 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.02527110701683e-09 1.18614697990646e-08 0.886037899619723 0.743119266055046 5.2 5 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00054526422396351 0.00175943535306139 0.885725364205395 0.742857142857143 5.2 5 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00054526422396351 0.00175943535306139 0.885725364205395 0.742857142857143 5.2 5 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00054526422396351 0.00175943535306139 0.885725364205395 0.742857142857143 5.2 5 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00054526422396351 0.00175943535306139 0.885725364205395 0.742857142857143 5.2 5 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 9.36179780093408e-09 9.65350599328202e-08 0.885022965026802 0.742268041237113 5.2 5 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.95894362444159e-08 1.82194560626169e-07 0.884626449361468 0.741935483870968 5.2 5 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00117959424334946 0.00347068263079694 0.884626449361468 0.741935483870968 5.2 5 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 8.59494590257114e-08 7.06971561812643e-07 0.883721460666469 0.741176470588235 5.2 5 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 8.59494590257114e-08 7.06971561812643e-07 0.883721460666469 0.741176470588235 5.2 5 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 8.59494590257114e-08 7.06971561812643e-07 0.883721460666469 0.741176470588235 5.2 5 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 8.59494590257114e-08 7.06971561812643e-07 0.883721460666469 0.741176470588235 5.2 5 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 8.59494590257114e-08 7.06971561812643e-07 0.883721460666469 0.741176470588235 5.2 5 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 8.59494590257114e-08 7.06971561812643e-07 0.883721460666469 0.741176470588235 5.2 5 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 8.59494590257114e-08 7.06971561812643e-07 0.883721460666469 0.741176470588235 5.2 5 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 8.59494590257114e-08 7.06971561812643e-07 0.883721460666469 0.741176470588235 5.2 5 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.02582171424833e-05 8.52882928809281e-05 0.88320193011934 0.740740740740741 5.2 5 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00256955646439472 0.00683453990436204 0.88320193011934 0.740740740740741 5.2 5 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.80247154681854e-07 1.30863112812387e-06 0.88320193011934 0.740740740740741 5.2 5 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.51200177106344e-09 3.9351011970262e-08 0.882777313806783 0.740384615384615 5.2 5 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 7.33847288433568e-09 7.73529401067383e-08 0.882318728189221 0.74 5.2 5 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 4.2994676337462e-05 0.00017137653901459 0.882318728189221 0.74 5.2 5 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.67228699965532e-06 8.55994388672489e-06 0.881281925923428 0.739130434782609 5.2 5 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 9.14877095334087e-05 0.00034259739648958 0.881281925923428 0.739130434782609 5.2 5 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 8.16528283016082e-17 4.00661981631684e-15 0.880047637511771 0.738095238095238 5.2 5 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.02644873060135e-15 1.54855041720155e-13 0.87989582663761 0.737967914438503 5.2 5 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.98996110464799e-13 5.66342930382817e-12 0.879701434664599 0.73780487804878 5.2 5 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 6.18962831870091e-07 3.53728558132988e-06 0.878553498908186 0.736842105263158 5.2 5 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0125656571830389 0.0284275519419147 0.878553498908186 0.736842105263158 5.2 5 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.29998416495365e-06 6.95442656665054e-06 0.877681918056094 0.736111111111111 5.2 5 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.29998416495365e-06 6.95442656665054e-06 0.877681918056094 0.736111111111111 5.2 5 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 3.32311853754699e-05 0.000134723580596278 0.87736946454308 0.735849056603774 5.2 5 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00090021943625848 0.00268556028888012 0.876707798280227 0.735294117647059 5.2 5 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00090021943625848 0.00268556028888012 0.876707798280227 0.735294117647059 5.2 5 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.05009347722481e-05 0.000269685027368035 0.875992118444896 0.73469387755102 5.2 5 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.25555658066573e-11 2.62743678571668e-10 0.875481633527388 0.734265734265734 5.2 5 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00194783889013932 0.00537165647416327 0.874369910818147 0.733333333333333 5.2 5 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0284444842291743 0.0562955508457789 0.874369910818147 0.733333333333333 5.2 5 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0284444842291743 0.0562955508457789 0.874369910818147 0.733333333333333 5.2 5 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00424395135830981 0.0108034754613146 0.871312673367734 0.730769230769231 5.2 5 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.00424395135830981 0.0108034754613146 0.871312673367734 0.730769230769231 5.2 5 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00424395135830981 0.0108034754613146 0.871312673367734 0.730769230769231 5.2 5 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.86083335493222e-12 6.78494310678093e-11 0.871312673367733 0.730769230769231 5.2 5 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.12398979726376e-62 1.59943748150633e-59 0.86996389213961 0.729638009049774 5.2 5 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000114841178550888 0.000428921252173 0.869401899961225 0.729166666666667 5.2 5 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 9.13876016367225e-09 9.49230344007709e-08 0.869169749921182 0.728971962616822 5.2 5 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 6.02734987305617e-07 3.47243678921414e-06 0.868481897950684 0.728395061728395 5.2 5 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 4.15412390744032e-05 0.000166048267423808 0.867143713208079 0.727272727272727 5.2 5 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00147272239383875 0.00421666794050813 0.867143713208079 0.727272727272727 5.2 5 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 2.22749576488322e-07 1.54945805775118e-06 0.867143713208079 0.727272727272727 5.2 5 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00933039166733349 0.0215888574676676 0.867143713208079 0.727272727272727 5.2 5 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.00933039166733349 0.0215888574676676 0.867143713208079 0.727272727272727 5.2 5 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00933039166733349 0.0215888574676676 0.867143713208079 0.727272727272727 5.2 5 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0661262342565024 0.112422498622465 0.867143713208079 0.727272727272727 5.2 5 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.63826560578576e-06 1.29012094743407e-05 0.865658878082723 0.726027397260274 5.2 5 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.17934657340461e-05 0.000129263147827279 0.863406024789079 0.724137931034483 5.2 5 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.17934657340461e-05 0.000129263147827279 0.863406024789079 0.724137931034483 5.2 5 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 7.46275869482463e-07 4.24780224909418e-06 0.861919955899597 0.72289156626506 5.2 5 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0207635836930292 0.0424519821769835 0.861121881866357 0.722222222222222 5.2 5 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0207635836930292 0.0424519821769835 0.861121881866357 0.722222222222222 5.2 5 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.0207635836930292 0.0424519821769835 0.861121881866357 0.722222222222222 5.2 5 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.73097493061027e-07 3.31511273425139e-06 0.85958141338359 0.720930232558139 5.2 5 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00692753484136031 0.0167936662338258 0.858472276075998 0.72 5.2 5 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000838119132202241 0.00252678712949955 0.856026486115668 0.717948717948718 5.2 5 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.000838119132202241 0.00252678712949955 0.856026486115668 0.717948717948718 5.2 5 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.000838119132202241 0.00252678712949955 0.856026486115668 0.717948717948718 5.2 5 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.3692087688742e-07 2.25521180929982e-06 0.855361869278622 0.717391304347826 5.2 5 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.44979413665048e-06 7.58476858990307e-06 0.851659004043649 0.714285714285714 5.2 5 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.44979413665048e-06 7.58476858990307e-06 0.851659004043649 0.714285714285714 5.2 5 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00063146583251181 0.0019968352881429 0.851659004043649 0.714285714285714 5.2 5 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00063146583251181 0.0019968352881429 0.851659004043649 0.714285714285714 5.2 5 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00178760746699591 0.00504715362209362 0.851659004043649 0.714285714285714 5.2 5 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0152037396501525 0.0339637700504977 0.851659004043649 0.714285714285714 5.2 5 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0152037396501525 0.0339637700504977 0.851659004043649 0.714285714285714 5.2 5 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0470089217760443 0.0842489870117267 0.851659004043649 0.714285714285714 5.2 5 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0470089217760443 0.0842489870117267 0.851659004043649 0.714285714285714 5.2 5 2 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_225157.1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_216831.1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.16102506158178 0.237942536480657 0.851659004043649 0.714285714285714 5.2 5 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.10647167103207e-06 5.98672695010888e-06 0.849701167252744 0.71264367816092 5.2 5 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.10647167103207e-06 5.98672695010888e-06 0.849701167252744 0.71264367816092 5.2 5 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.69691327225079e-12 4.09272472273369e-11 0.84888185511742 0.71195652173913 5.2 5 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.2747982276165e-08 3.77828439621011e-07 0.848589962587636 0.711711711711712 5.2 5 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000170615324606933 0.000616207124151437 0.848383392489635 0.711538461538462 5.2 5 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000170615324606933 0.000616207124151437 0.848383392489635 0.711538461538462 5.2 5 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.000475557263218938 0.00155567353002425 0.847873852914566 0.711111111111111 5.2 5 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 6.23602564752243e-06 2.90946376931948e-05 0.847176588232893 0.710526315789474 5.2 5 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00133920530638483 0.00385767034612472 0.847176588232893 0.710526315789474 5.2 5 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.70357284903379e-05 7.25803641968589e-05 0.846721850397019 0.710144927536232 5.2 5 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00382577024895897 0.00997082612503409 0.846164429824013 0.709677419354839 5.2 5 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000128921333066635 0.000477747544150578 0.845465120377877 0.709090909090909 5.2 5 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.000358052010520638 0.00118766436123745 0.844561845676619 0.708333333333333 5.2 5 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0111650306991715 0.0253394556378327 0.844561845676619 0.708333333333333 5.2 5 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0111650306991715 0.0253394556378327 0.844561845676619 0.708333333333333 5.2 5 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 5.21586216272399e-32 7.42217185755623e-30 0.84177082834127 0.705992509363296 5.2 5 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000269548534693734 0.000917625753275557 0.841639486349018 0.705882352941177 5.2 5 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.033746903556855 0.0646909129410867 0.841639486349018 0.705882352941177 5.2 5 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.033746903556855 0.0646909129410867 0.841639486349018 0.705882352941177 5.2 5 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.033746903556855 0.0646909129410867 0.841639486349018 0.705882352941177 5.2 5 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.00352040211234e-08 1.00564051563793e-07 0.837356333746733 0.702290076335878 5.2 5 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.00352040211234e-08 1.00564051563793e-07 0.837356333746733 0.702290076335878 5.2 5 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.36841480676547e-07 2.25521180929982e-06 0.836918752050586 0.701923076923077 5.2 5 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 3.16562866029173e-05 0.000129263147827279 0.834625823962776 0.7 5.2 5 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.00158050968645765 0.00448020972874351 0.834625823962776 0.7 5.2 5 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00158050968645765 0.00448020972874351 0.834625823962776 0.7 5.2 5 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0244037080784242 0.0489795156496441 0.834625823962776 0.7 5.2 5 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0244037080784242 0.0489795156496441 0.834625823962776 0.7 5.2 5 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.109256361998167 0.172363418096887 0.834625823962776 0.7 5.2 5 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.109256361998167 0.172363418096887 0.834625823962776 0.7 5.2 5 2 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.109256361998167 0.172363418096887 0.834625823962776 0.7 5.2 5 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.109256361998167 0.172363418096887 0.834625823962776 0.7 5.2 5 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 1.80435948542294e-05 7.66448820225926e-05 0.831488132895247 0.697368421052632 5.2 5 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 6.52187989353107e-05 0.00025356926471297 0.831012725157743 0.696969696969697 5.2 5 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0044865386235227 0.0112997247102173 0.831012725157743 0.696969696969697 5.2 5 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0044865386235227 0.0112997247102173 0.831012725157743 0.696969696969697 5.2 5 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.12393850232122e-09 1.2898100716154e-08 0.830779622009031 0.696774193548387 5.2 5 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.36228608264618e-05 5.94642053866723e-05 0.830098016599506 0.69620253164557 5.2 5 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0177475684974438 0.0380916892486614 0.829441812633815 0.695652173913043 5.2 5 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.17546567785446e-06 1.0711722005491e-05 0.828350441827718 0.694736842105263 5.2 5 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.17546567785446e-06 1.0711722005491e-05 0.828350441827718 0.694736842105263 5.2 5 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.70057854912653e-05 0.00014875489478551 0.828001809486881 0.694444444444444 5.2 5 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.63495223312275e-07 2.78292701592138e-06 0.828001809486881 0.694444444444444 5.2 5 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.21723310929827e-18 1.90755113105477e-16 0.826579475090217 0.693251533742331 5.2 5 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0760847186082627 0.125747450150474 0.825454111611537 0.692307692307692 5.2 5 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0760847186082627 0.125747450150474 0.825454111611537 0.692307692307692 5.2 5 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0760847186082627 0.125747450150474 0.825454111611537 0.692307692307692 5.2 5 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0760847186082627 0.125747450150474 0.825454111611537 0.692307692307692 5.2 5 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0760847186082627 0.125747450150474 0.825454111611537 0.692307692307692 5.2 5 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0760847186082627 0.125747450150474 0.825454111611537 0.692307692307692 5.2 5 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.27551536915725e-08 2.91316148144423e-07 0.824764509179113 0.691729323308271 5.2 5 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.000116232939337302 0.000431852409078277 0.818609550155388 0.686567164179104 5.2 5 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.53276088854481e-07 1.15008393163582e-06 0.816787926712728 0.68503937007874 5.2 5 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 4.15490936738996e-32 6.5693733664399e-30 0.815897272925176 0.684292379471229 5.2 5 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0385257577980082 0.0722199696216935 0.815799677557601 0.684210526315789 5.2 5 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.43205834653876e-06 7.54747787823947e-06 0.812947231132574 0.681818181818182 5.2 5 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.57234020169812e-05 6.80072980856057e-05 0.812947231132574 0.681818181818182 5.2 5 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0277894853276219 0.0553092799008727 0.812947231132574 0.681818181818182 5.2 5 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0277894853276219 0.0553092799008727 0.812947231132574 0.681818181818182 5.2 5 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.00155648236287542 0.00442974880474345 0.81179411449267 0.680851063829787 5.2 5 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.37565879508634e-05 9.85586724608708e-05 0.80858659464374 0.67816091954023 5.2 5 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 4.93258128666863e-10 6.1482762713077e-09 0.807301764249709 0.677083333333333 5.2 5 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00791523044391364 0.0189619072755709 0.806571174417809 0.676470588235294 5.2 5 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 4.23794724623832e-36 1.00509982189952e-33 0.806077254531454 0.676056338028169 5.2 5 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.34356543096812e-13 4.15629045275573e-12 0.80492536916472 0.675090252707581 5.2 5 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 7.89651840150686e-07 4.47679110969891e-06 0.804575416828228 0.67479674796748 5.2 5 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00318759406943164 0.00844682748752556 0.804124548004004 0.674418604651163 5.2 5 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00175502389611263 0.0049650079605731 0.802992775241155 0.673469387755102 5.2 5 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000724406109501848 0.00221208131721272 0.801734165875573 0.672413793103448 5.2 5 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000724406109501848 0.00221208131721272 0.801734165875573 0.672413793103448 5.2 5 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000724406109501848 0.00221208131721272 0.801734165875573 0.672413793103448 5.2 5 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00882470207827767 0.0208698866596573 0.794881737107406 0.666666666666667 5.2 5 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0597135432845062 0.103878205493707 0.794881737107406 0.666666666666667 5.2 5 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0597135432845062 0.103878205493707 0.794881737107406 0.666666666666667 5.2 5 2 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0597135432845062 0.103878205493707 0.794881737107406 0.666666666666667 5.2 5 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.175451125804837 0.256331572916102 0.794881737107406 0.666666666666667 5.2 5 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0120067168842572 0.0272063027488821 0.794881737107406 0.666666666666667 5.2 5 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0163885516324422 0.0356892207859419 0.794881737107406 0.666666666666667 5.2 5 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0163885516324422 0.0356892207859419 0.794881737107406 0.666666666666667 5.2 5 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0163885516324422 0.0356892207859419 0.794881737107406 0.666666666666667 5.2 5 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0224555145719554 0.0455187994813284 0.794881737107406 0.666666666666667 5.2 5 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0224555145719554 0.0455187994813284 0.794881737107406 0.666666666666667 5.2 5 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0224555145719554 0.0455187994813284 0.794881737107406 0.666666666666667 5.2 5 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0224555145719554 0.0455187994813284 0.794881737107406 0.666666666666667 5.2 5 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0428036449349677 0.0783561179591651 0.794881737107406 0.666666666666667 5.2 5 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0841377968697841 0.138413971035495 0.794881737107406 0.666666666666667 5.2 5 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.0841377968697841 0.138413971035495 0.794881737107406 0.666666666666667 5.2 5 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0841377968697841 0.138413971035495 0.794881737107406 0.666666666666667 5.2 5 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.120220759538722 0.188615370257553 0.794881737107406 0.666666666666667 5.2 5 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.120220759538722 0.188615370257553 0.794881737107406 0.666666666666667 5.2 5 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.120220759538722 0.188615370257553 0.794881737107406 0.666666666666667 5.2 5 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.29752029275501e-07 1.02576187588354e-06 0.792317602471576 0.664516129032258 5.2 5 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.73406907115131e-05 0.000149678317978826 0.790698149017367 0.663157894736842 5.2 5 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.1991877770764e-06 1.53798790769585e-05 0.78847140051783 0.661290322580645 5.2 5 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00120047234189019 0.00351496325619289 0.788145451199716 0.661016949152542 5.2 5 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 6.41663586232427e-11 1.17062472206249e-09 0.785418859284699 0.658730158730159 5.2 5 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 6.41663586232427e-11 1.17062472206249e-09 0.785418859284699 0.658730158730159 5.2 5 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 6.41663586232427e-11 1.17062472206249e-09 0.785418859284699 0.658730158730159 5.2 5 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0245987421975491 0.0493014227424117 0.781176879571071 0.655172413793103 5.2 5 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0337774759769694 0.0646909129410867 0.779595549855341 0.653846153846154 5.2 5 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0337774759769694 0.0646909129410867 0.779595549855341 0.653846153846154 5.2 5 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00429699152986203 0.010899499014249 0.778659660839908 0.653061224489796 5.2 5 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00429699152986203 0.010899499014249 0.778659660839908 0.653061224489796 5.2 5 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 9.92282253321853e-06 4.48259570310158e-05 0.778458560720889 0.652892561983471 5.2 5 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00579259544061511 0.0140903646358894 0.777601699344202 0.652173913043478 5.2 5 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0466180793842059 0.083759503742077 0.777601699344202 0.652173913043478 5.2 5 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0466180793842059 0.083759503742077 0.777601699344202 0.652173913043478 5.2 5 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0466180793842059 0.083759503742077 0.777601699344202 0.652173913043478 5.2 5 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0466180793842059 0.083759503742077 0.777601699344202 0.652173913043478 5.2 5 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0647524215629498 0.11155290058605 0.775009693679721 0.65 5.2 5 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0647524215629498 0.11155290058605 0.775009693679721 0.65 5.2 5 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0647524215629498 0.11155290058605 0.775009693679721 0.65 5.2 5 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.014350016355909 0.0322083174676001 0.773398446915314 0.648648648648649 5.2 5 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00347124920529121 0.00906346352133833 0.772801688854422 0.648148148148148 5.2 5 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.56025069391507e-05 6.76901444341814e-05 0.772077752846128 0.647540983606557 5.2 5 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0195077753582204 0.0405318748398333 0.7715028624866 0.647058823529412 5.2 5 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0195077753582204 0.0405318748398333 0.7715028624866 0.647058823529412 5.2 5 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0906861037926096 0.147988905615692 0.7715028624866 0.647058823529412 5.2 5 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0906861037926096 0.147988905615692 0.7715028624866 0.647058823529412 5.2 5 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00627846502035825 0.0152461701774229 0.7700416828228 0.645833333333333 5.2 5 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00846187654839716 0.0202034401482704 0.768385679203826 0.644444444444444 5.2 5 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.72467992447036e-06 8.79203332488321e-06 0.767035561603643 0.643312101910828 5.2 5 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0363950845952824 0.0695170542001165 0.766493103639284 0.642857142857143 5.2 5 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0363950845952824 0.0695170542001165 0.766493103639284 0.642857142857143 5.2 5 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.128421152906256 0.198850163858109 0.766493103639284 0.642857142857143 5.2 5 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0154509591679896 0.0344619355737448 0.764309362603275 0.641025641025641 5.2 5 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.92034712160402e-07 1.37319294172991e-06 0.763831669251648 0.640625 5.2 5 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0500111946663755 0.0891803634213688 0.76308646762311 0.64 5.2 5 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0500111946663755 0.0891803634213688 0.76308646762311 0.64 5.2 5 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0500111946663755 0.0891803634213688 0.76308646762311 0.64 5.2 5 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.08925334241804e-32 3.71625938282608e-30 0.762656801819268 0.63963963963964 5.2 5 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00300873162148293 0.00798773339061606 0.762304616734152 0.639344262295082 5.2 5 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.0018085760312725 0.00507473081030859 0.760321661580997 0.63768115942029 5.2 5 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 3.6048374535654e-16 1.65473667626567e-14 0.758750749057069 0.636363636363636 5.2 5 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0690784242478229 0.117301429241828 0.758750749057069 0.636363636363636 5.2 5 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.184734085546081 0.268515427714068 0.758750749057069 0.636363636363636 5.2 5 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.184734085546081 0.268515427714068 0.758750749057069 0.636363636363636 5.2 5 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.184734085546081 0.268515427714068 0.758750749057069 0.636363636363636 5.2 5 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.184734085546081 0.268515427714068 0.758750749057069 0.636363636363636 5.2 5 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.184734085546081 0.268515427714068 0.758750749057069 0.636363636363636 5.2 5 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0165016449186342 0.0358501385026205 0.756107018224118 0.634146341463415 5.2 5 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0387799804463699 0.0722199696216935 0.755137650252036 0.633333333333333 5.2 5 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 9.81883994587045e-47 6.98610462148682e-44 0.755111992352194 0.633311814073596 5.2 5 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0222949048623684 0.0455174313043762 0.753045856207016 0.631578947368421 5.2 5 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.030181115687475 0.0581947528770689 0.749459923558411 0.628571428571429 5.2 5 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000222221272810606 0.000765667969030247 0.747911452641968 0.627272727272727 5.2 5 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0137637749389369 0.0309413139622547 0.745201628538193 0.625 5.2 5 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0409480722413113 0.0755760140069857 0.745201628538193 0.625 5.2 5 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0727938048679018 0.122343718944222 0.745201628538193 0.625 5.2 5 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0727938048679018 0.122343718944222 0.745201628538193 0.625 5.2 5 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.134628971860497 0.206749668629494 0.745201628538193 0.625 5.2 5 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.134628971860497 0.206749668629494 0.745201628538193 0.625 5.2 5 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.134628971860497 0.206749668629494 0.745201628538193 0.625 5.2 5 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.134628971860497 0.206749668629494 0.745201628538193 0.625 5.2 5 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.134628971860497 0.206749668629494 0.745201628538193 0.625 5.2 5 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604910 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 RELAXIN RECEPTORS%REACTOME%REACT_198713.2 RELAXIN RECEPTORS 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.272203573259024 0.361403556605663 0.745201628538193 0.625 5.2 5 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0184494029777253 0.0395384042730469 0.741889621300246 0.622222222222222 5.2 5 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.39299121112999e-12 3.4176318852379e-11 0.740523232663962 0.621076233183857 5.2 5 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.47004510158822e-13 4.45079612672348e-12 0.739143078712679 0.619918699186992 5.2 5 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.100419183583421 0.159304903276709 0.738104470171163 0.619047619047619 5.2 5 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.2404967300123e-15 1.28089634633542e-13 0.737110122238829 0.618213660245184 5.2 5 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0759851445694251 0.125747450150474 0.733736988099144 0.615384615384615 5.2 5 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.190838425027456 0.275978738632185 0.733736988099144 0.615384615384615 5.2 5 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.190838425027456 0.275978738632185 0.733736988099144 0.615384615384615 5.2 5 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.190838425027456 0.275978738632185 0.733736988099144 0.615384615384615 5.2 5 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.190838425027456 0.275978738632185 0.733736988099144 0.615384615384615 5.2 5 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.190838425027456 0.275978738632185 0.733736988099144 0.615384615384615 5.2 5 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0580671590082104 0.101385972108814 0.730778371211647 0.612903225806452 5.2 5 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0580671590082104 0.101385972108814 0.730778371211647 0.612903225806452 5.2 5 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.139357270305343 0.209403796879096 0.728641592348455 0.611111111111111 5.2 5 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.000168346905585553 0.000611539321961859 0.72723222756635 0.609929078014184 5.2 5 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0787252956467285 0.129960667871572 0.723910153437102 0.607142857142857 5.2 5 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0601638970591433 0.104279202819928 0.722619761006733 0.606060606060606 5.2 5 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0601638970591433 0.104279202819928 0.722619761006733 0.606060606060606 5.2 5 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0601638970591433 0.104279202819928 0.722619761006733 0.606060606060606 5.2 5 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0463103284646951 0.0836289307173364 0.721668945531724 0.605263157894737 5.2 5 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00498447371865996 0.0124001854924006 0.721281576264128 0.604938271604938 5.2 5 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0278684143984018 0.0553092799008727 0.720361574253587 0.604166666666667 5.2 5 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0278684143984018 0.0553092799008727 0.720361574253587 0.604166666666667 5.2 5 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0278684143984018 0.0553092799008727 0.720361574253587 0.604166666666667 5.2 5 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 2.03604012237828e-05 8.54656369954069e-05 0.720235482607472 0.604060913705584 5.2 5 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0224516704896137 0.0455187994813284 0.715393563396665 0.6 5.2 5 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.142960020808975 0.214590832923177 0.715393563396665 0.6 5.2 5 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.194846186960963 0.281488450807564 0.715393563396665 0.6 5.2 5 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.274743271514842 0.361403556605663 0.715393563396665 0.6 5.2 5 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.274743271514842 0.361403556605663 0.715393563396665 0.6 5.2 5 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.274743271514842 0.361403556605663 0.715393563396665 0.6 5.2 5 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.274743271514842 0.361403556605663 0.715393563396665 0.6 5.2 5 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.274743271514842 0.361403556605663 0.715393563396665 0.6 5.2 5 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.274743271514842 0.361403556605663 0.715393563396665 0.6 5.2 5 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.274743271514842 0.361403556605663 0.715393563396665 0.6 5.2 5 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.274743271514842 0.361403556605663 0.715393563396665 0.6 5.2 5 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0490795373105253 0.0878492850224875 0.709715836703041 0.595238095238095 5.2 5 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.145689169290395 0.218456994626167 0.704554266981564 0.590909090909091 5.2 5 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0848044703076043 0.139028526783089 0.701366238624182 0.588235294117647 5.2 5 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0848044703076043 0.139028526783089 0.701366238624182 0.588235294117647 5.2 5 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.197404497671765 0.284318421241824 0.701366238624182 0.588235294117647 5.2 5 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.197404497671765 0.284318421241824 0.701366238624182 0.588235294117647 5.2 5 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.45496818158322e-05 6.3315587840762e-05 0.701366238624182 0.588235294117647 5.2 5 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0248564718355634 0.0497479035471261 0.700252958880334 0.587301587301587 5.2 5 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00806380729347965 0.0192853744178513 0.697635567142138 0.585106382978723 5.2 5 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.147728845537217 0.221049576445278 0.69552151996898 0.583333333333333 5.2 5 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.147728845537217 0.221049576445278 0.69552151996898 0.583333333333333 5.2 5 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.275052741956383 0.361403556605663 0.69552151996898 0.583333333333333 5.2 5 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.275052741956383 0.361403556605663 0.69552151996898 0.583333333333333 5.2 5 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0413951230016246 0.0763021502996268 0.693714970566463 0.581818181818182 5.2 5 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0420534554877771 0.0774153520816388 0.690292034856432 0.578947368421053 5.2 5 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.000543988926422299 0.00175943535306139 0.689613615166155 0.578378378378378 5.2 5 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.00880315602477182 0.0208698866596573 0.687878426342947 0.576923076923077 5.2 5 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.114197780460217 0.179959514501538 0.686488772956396 0.575757575757576 5.2 5 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000168463397195396 0.000611539321961859 0.685713429865187 0.575107296137339 5.2 5 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.27406145452239 0.361403556605663 0.681327203234919 0.571428571428571 5.2 5 2 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.27406145452239 0.361403556605663 0.681327203234919 0.571428571428571 5.2 5 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.27406145452239 0.361403556605663 0.681327203234919 0.571428571428571 5.2 5 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.27406145452239 0.361403556605663 0.681327203234919 0.571428571428571 5.2 5 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0021511743367536 0.0058530039793506 0.68028222286186 0.570552147239264 5.2 5 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0144547680558289 0.0323923384936134 0.679623885226832 0.57 5.2 5 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.15093286593253 0.225606584266796 0.675649476541295 0.566666666666667 5.2 5 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00343227375076377 0.00899470634868665 0.674899588110062 0.566037735849057 5.2 5 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00343227375076377 0.00899470634868665 0.674899588110062 0.566037735849057 5.2 5 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00346233435600234 0.00905680475843995 0.673921472764975 0.565217391304348 5.2 5 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0448225469472128 0.0810450880633848 0.673921472764975 0.565217391304348 5.2 5 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.090654656359177 0.147988905615692 0.673921472764975 0.565217391304348 5.2 5 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0287353519193983 0.0567134615552064 0.673311589079214 0.564705882352941 5.2 5 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0287353519193983 0.0567134615552064 0.673311589079214 0.564705882352941 5.2 5 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0568273459422783 0.0994653299826101 0.670681465684374 0.5625 5.2 5 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00439475139975918 0.0111276356616678 0.669761463673833 0.561728395061728 5.2 5 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0044232398113475 0.011179876112873 0.66886390073672 0.560975609756098 5.2 5 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0190032972566439 0.0405318748398333 0.668592115323986 0.560747663551402 5.2 5 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.199606641458885 0.286042548636449 0.667700659170221 0.56 5.2 5 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.199606641458885 0.286042548636449 0.667700659170221 0.56 5.2 5 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.199606641458885 0.286042548636449 0.667700659170221 0.56 5.2 5 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.199010052620894 0.286042548636449 0.662401447589505 0.555555555555556 5.2 5 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.269963531879792 0.361403556605663 0.662401447589505 0.555555555555556 5.2 5 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.393144132576757 0.507662523281965 0.662401447589505 0.555555555555556 5.2 5 2 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.393144132576757 0.507662523281965 0.662401447589505 0.555555555555556 5.2 5 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.393144132576757 0.507662523281965 0.662401447589505 0.555555555555556 5.2 5 2 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.393144132576757 0.507662523281965 0.662401447589505 0.555555555555556 5.2 5 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.198147517947654 0.285100018240154 0.65783316174406 0.551724137931034 5.2 5 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.267326102879742 0.359551081661505 0.65577743311361 0.55 5.2 5 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.267326102879742 0.359551081661505 0.65577743311361 0.55 5.2 5 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0130138187955185 0.0293016837753525 0.653854332136737 0.548387096774194 5.2 5 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.382754294677357 0.496951972012663 0.650357784906059 0.545454545454545 5.2 5 2 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.382754294677357 0.496951972012663 0.650357784906059 0.545454545454545 5.2 5 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.382754294677357 0.496951972012663 0.650357784906059 0.545454545454545 5.2 5 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.382754294677357 0.496951972012663 0.650357784906059 0.545454545454545 5.2 5 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0719270397385986 0.121993060247945 0.647681415420849 0.54320987654321 5.2 5 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.114666379089676 0.180498072394478 0.645026983390436 0.540983606557377 5.2 5 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.373302778373463 0.486455909913405 0.642019864586751 0.538461538461538 5.2 5 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.373302778373463 0.486455909913405 0.642019864586751 0.538461538461538 5.2 5 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0861600133957612 0.141088261291333 0.635905389685925 0.533333333333333 5.2 5 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.252107120250654 0.343628766395288 0.635905389685925 0.533333333333333 5.2 5 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.356490121525084 0.466255002693194 0.631229614761764 0.529411764705882 5.2 5 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.356490121525084 0.466255002693194 0.631229614761764 0.529411764705882 5.2 5 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.356490121525084 0.466255002693194 0.631229614761764 0.529411764705882 5.2 5 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.050839097485441 0.0904300446522282 0.6302276629923 0.528571428571429 5.2 5 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0504984240904111 0.0899364924664017 0.629747855102698 0.528169014084507 5.2 5 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.101872246564881 0.161430074456376 0.627538213505847 0.526315789473684 5.2 5 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0610113368028338 0.105619382324127 0.626622099325546 0.525547445255474 5.2 5 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0723477091824321 0.122343718944222 0.622462536778961 0.522058823529412 5.2 5 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.084542897651394 0.138919796025328 0.617919014612691 0.518248175182482 5.2 5 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0278592782306926 0.0553092799008727 0.61720228998928 0.517647058823529 5.2 5 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.195352879330059 0.281934226457073 0.613194482911427 0.514285714285714 5.2 5 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.285499091615191 0.37478340163138 0.610701822411788 0.51219512195122 5.2 5 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.372668803101514 0.486455909913405 0.596161302830554 0.5 5.2 5 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.443016711170377 0.549140052260842 0.596161302830554 0.5 5.2 5 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.45691805709505 0.558106777035412 0.596161302830554 0.5 5.2 5 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.49045584739833 0.598045133545693 0.596161302830554 0.5 5.2 5 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.49045584739833 0.598045133545693 0.596161302830554 0.5 5.2 5 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.511544993638671 0.622161133288743 0.596161302830554 0.5 5.2 5 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.511544993638671 0.622161133288743 0.596161302830554 0.5 5.2 5 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.25997963361646 0.354020113527486 0.589750966240979 0.494623655913978 5.2 5 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.408028406407898 0.524502639854055 0.580875115578489 0.487179487179487 5.2 5 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.369197739201922 0.482431940206 0.573522266014204 0.481012658227848 5.2 5 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.420488023423819 0.534722481976849 0.572314850717332 0.48 5.2 5 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.384360751596832 0.49858281633755 0.569063061792802 0.477272727272727 5.2 5 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.429651185024579 0.53889484661815 0.566841894494626 0.475409836065574 5.2 5 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.392121091806821 0.507662523281965 0.566052146121941 0.474747474747475 5.2 5 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0632434364491419 0.109350437505624 0.563590538968592 0.472682926829268 5.2 5 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.323876356748694 0.42477055820589 0.562094942668808 0.471428571428571 5.2 5 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.54618733315724 0.660343734139977 0.561092990899345 0.470588235294118 5.2 5 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.511522259403068 0.622161133288743 0.558901221403645 0.46875 5.2 5 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.524684950164153 0.637053484712961 0.556417215975184 0.466666666666667 5.2 5 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.524684950164153 0.637053484712961 0.556417215975184 0.466666666666667 5.2 5 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.56700115140249 0.682607985148683 0.556417215975184 0.466666666666667 5.2 5 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.56700115140249 0.682607985148683 0.556417215975184 0.466666666666667 5.2 5 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.538753896619054 0.651910539871526 0.553578352628372 0.464285714285714 5.2 5 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.553862617341261 0.668487281150649 0.550302741074358 0.461538461538462 5.2 5 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.547536215488265 0.661412593072837 0.547823899898347 0.459459459459459 5.2 5 2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.618870576106433 0.729179874654289 0.541964820755049 0.454545454545455 5.2 5 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.618870576106433 0.729179874654289 0.541964820755049 0.454545454545455 5.2 5 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.559770429827024 0.675045187833775 0.540847367516379 0.45360824742268 5.2 5 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.621411706446106 0.731405176404309 0.529921158071604 0.444444444444444 5.2 5 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.812129700351416 0.914288420569672 0.51099540242619 0.428571428571429 5.2 5 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.702176945185859 0.809455526712268 0.502030570804678 0.421052631578947 5.2 5 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.702176945185859 0.809455526712268 0.502030570804678 0.421052631578947 5.2 5 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.710595382326507 0.814808403747477 0.496801085692129 0.416666666666667 5.2 5 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.710595382326507 0.814808403747477 0.496801085692129 0.416666666666667 5.2 5 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.710595382326507 0.814808403747477 0.496801085692129 0.416666666666667 5.2 5 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.908972582256539 0.994272992775473 0.487768338679545 0.409090909090909 5.2 5 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.754697998758299 0.855725300584112 0.476929042264444 0.4 5.2 5 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.765426312451549 0.867198760046619 0.476929042264444 0.4 5.2 5 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.876224033419602 0.963575579255095 0.456634189402127 0.382978723404255 5.2 5 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.818344590015566 0.919829661605174 0.454218135489946 0.380952380952381 5.2 5 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.902248549722976 0.991428329155054 0.449933058740041 0.377358490566038 5.2 5 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.81594399649498 0.917856369179729 0.447120977122916 0.375 5.2 5 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.840825021551231 0.932575218758692 0.439276749454093 0.368421052631579 5.2 5 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.844201329602917 0.933409861713249 0.425829502021825 0.357142857142857 5.2 5 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.942347861071548 1 0.422280922838309 0.354166666666667 5.2 5 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.945917335458073 1 0.397440868553703 0.333333333333333 5.2 5 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.95948221421545 1 0.3857514312433 0.323529411764706 5.2 5 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.922138903448066 1 0.372600814269097 0.3125 5.2 5 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.988935334682324 1 0.364996716018707 0.306122448979592 5.2 5 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.9732506097295 1 0.357696781698333 0.3 5.2 5 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.993415484503666 1 0.34776075998449 0.291666666666667 5.2 5 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.346384233046804 0.290512174643157 5.2 5 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.980827696727223 1 0.346158175837096 0.290322580645161 5.2 5 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.980827696727223 1 0.346158175837096 0.290322580645161 5.2 5 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.980827696727223 1 0.346158175837096 0.290322580645161 5.2 5 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999998809459857 1 0.346158175837096 0.290322580645161 5.2 5 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.988333494317426 1 0.345146017428216 0.289473684210526 5.2 5 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.979249463422503 1 0.34066360161746 0.285714285714286 5.2 5 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.977711534858064 1 0.333850329585111 0.28 5.2 5 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.999608472753782 1 0.332039206639802 0.278481012658228 5.2 5 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.976324036989387 1 0.32517889245303 0.272727272727273 5.2 5 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.976324036989387 1 0.32517889245303 0.272727272727273 5.2 5 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.99965328494597 1 0.319072246585367 0.267605633802817 5.2 5 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.310478219195659 0.260397830018083 5.2 5 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.995348364270259 1 0.306597241455714 0.257142857142857 5.2 5 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.983512434533545 1 0.298080651415277 0.25 5.2 5 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999533449247193 1 0.279054226856855 0.234042553191489 5.2 5 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.997828584969114 1 0.269234136762186 0.225806451612903 5.2 5 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999999998055 1 0.176640386023868 0.148148148148148 5.2 5 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999999998299 1 0.145728318469691 0.122222222222222 5.2 5 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0480775244218189 0.0403225806451613 5.2 5 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 3.72128294957377e-08 2.03668678355518e-07 1.35126143609648 1 5.6 5 6 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 3.72128294957377e-08 2.03668678355518e-07 1.35126143609648 1 5.6 5 6 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 1.14053428898025e-06 5.21858615182923e-06 1.35126143609648 1 5.6 5 6 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 8.21746959130406e-05 0.000285206322644529 1.35126143609648 1 5.6 5 6 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 8.21746959130406e-05 0.000285206322644529 1.35126143609648 1 5.6 5 6 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 8.21746959130406e-05 0.000285206322644529 1.35126143609648 1 5.6 5 6 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 8.21746959130406e-05 0.000285206322644529 1.35126143609648 1 5.6 5 6 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 8.21746959130406e-05 0.000285206322644529 1.35126143609648 1 5.6 5 6 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0001932912080174 0.000628375323234413 1.35126143609648 1 5.6 5 6 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0001932912080174 0.000628375323234413 1.35126143609648 1 5.6 5 6 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0001932912080174 0.000628375323234413 1.35126143609648 1 5.6 5 6 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0001932912080174 0.000628375323234413 1.35126143609648 1 5.6 5 6 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000454641190090166 0.00137357624946562 1.35126143609648 1 5.6 5 6 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000454641190090166 0.00137357624946562 1.35126143609648 1 5.6 5 6 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000454641190090166 0.00137357624946562 1.35126143609648 1 5.6 5 6 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.000454641190090166 0.00137357624946562 1.35126143609648 1 5.6 5 6 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000454641190090166 0.00137357624946562 1.35126143609648 1 5.6 5 6 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00106932112365451 0.00288190143742495 1.35126143609648 1 5.6 5 6 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.00106932112365451 0.00288190143742495 1.35126143609648 1 5.6 5 6 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00106932112365451 0.00288190143742495 1.35126143609648 1 5.6 5 6 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.00106932112365451 0.00288190143742495 1.35126143609648 1 5.6 5 6 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00106932112365451 0.00288190143742495 1.35126143609648 1 5.6 5 6 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%REACT_208690.1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%REACT_209262.1 CLEAVAGE OF THE DAMAGED PYRIMIDINE 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 DEPYRIMIDINATION%REACTOME%REACT_206945.1 DEPYRIMIDINATION 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 48%5605580 G BETA:GAMMA SIGNALLING THROUGH PLC BETA 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 48%5604835 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0139098479161985 0.0275145694066262 1.35126143609648 1 5.6 5 6 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 2.6832982172366e-06 1.17487180403929e-05 1.35126143609648 1 5.6 5 6 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 2.6832982172366e-06 1.17487180403929e-05 1.35126143609648 1 5.6 5 6 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 6.31265731556079e-06 2.61131144187297e-05 1.35126143609648 1 5.6 5 6 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 3.49338775979214e-05 0.000129119241095694 1.35126143609648 1 5.6 5 6 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00251495489570696 0.00625660981921505 1.35126143609648 1 5.6 5 6 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00251495489570696 0.00625660981921505 1.35126143609648 1 5.6 5 6 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00251495489570696 0.00625660981921505 1.35126143609648 1 5.6 5 6 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00251495489570696 0.00625660981921505 1.35126143609648 1 5.6 5 6 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00251495489570696 0.00625660981921505 1.35126143609648 1 5.6 5 6 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00251495489570696 0.00625660981921505 1.35126143609648 1 5.6 5 6 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00591473028377401 0.0133320192842831 1.35126143609648 1 5.6 5 6 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.00591473028377401 0.0133320192842831 1.35126143609648 1 5.6 5 6 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00591473028377401 0.0133320192842831 1.35126143609648 1 5.6 5 6 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00591473028377401 0.0133320192842831 1.35126143609648 1 5.6 5 6 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00591473028377401 0.0133320192842831 1.35126143609648 1 5.6 5 6 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.00591473028377401 0.0133320192842831 1.35126143609648 1 5.6 5 6 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.00591473028377401 0.0133320192842831 1.35126143609648 1 5.6 5 6 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.79611502202847e-08 1.02234867053861e-07 1.29721097865262 0.96 5.6 5 6 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 1.04422417497273e-06 4.80883819089385e-06 1.28369836429166 0.95 5.6 5 6 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 2.33847135547728e-06 1.0302305693016e-05 1.28014241314403 0.947368421052632 5.6 5 6 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 2.33847135547728e-06 1.0302305693016e-05 1.28014241314403 0.947368421052632 5.6 5 6 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 1.16328577515065e-05 4.64987544393085e-05 1.27177546926727 0.941176470588235 5.6 5 6 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 1.16328577515065e-05 4.64987544393085e-05 1.27177546926727 0.941176470588235 5.6 5 6 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 1.16328577515065e-05 4.64987544393085e-05 1.27177546926727 0.941176470588235 5.6 5 6 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.16328577515065e-05 4.64987544393085e-05 1.27177546926727 0.941176470588235 5.6 5 6 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 2.5824757141082e-05 9.59494240515918e-05 1.26680759634045 0.9375 5.6 5 6 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 2.5824757141082e-05 9.59494240515918e-05 1.26680759634045 0.9375 5.6 5 6 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 2.5824757141082e-05 9.59494240515918e-05 1.26680759634045 0.9375 5.6 5 6 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 2.5824757141082e-05 9.59494240515918e-05 1.26680759634045 0.9375 5.6 5 6 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 2.5824757141082e-05 9.59494240515918e-05 1.26680759634045 0.9375 5.6 5 6 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 2.5824757141082e-05 9.59494240515918e-05 1.26680759634045 0.9375 5.6 5 6 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.3175535090479e-08 7.59060179504113e-08 1.25807099222776 0.931034482758621 5.6 5 6 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 2.89272172621539e-08 1.61658179681879e-07 1.25474276208959 0.928571428571429 5.6 5 6 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000125841060946391 0.000419371966573103 1.25474276208959 0.928571428571429 5.6 5 6 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000125841060946391 0.000419371966573103 1.25474276208959 0.928571428571429 5.6 5 6 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000125841060946391 0.000419371966573103 1.25474276208959 0.928571428571429 5.6 5 6 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.000125841060946391 0.000419371966573103 1.25474276208959 0.928571428571429 5.6 5 6 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.000125841060946391 0.000419371966573103 1.25474276208959 0.928571428571429 5.6 5 6 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.33493477983729e-08 3.40174044970131e-07 1.25116799638563 0.925925925925926 5.6 5 6 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.38354680601132e-07 7.10190819478793e-07 1.24731824870444 0.923076923076923 5.6 5 6 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000275935603588395 0.000869592081089698 1.24731824870444 0.923076923076923 5.6 5 6 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.000275935603588395 0.000869592081089698 1.24731824870444 0.923076923076923 5.6 5 6 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.000275935603588395 0.000869592081089698 1.24731824870444 0.923076923076923 5.6 5 6 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 7.93843190735285e-10 5.82288072379542e-09 1.23865631642177 0.916666666666667 5.6 5 6 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 6.53994407831557e-07 3.19805512833095e-06 1.23865631642177 0.916666666666667 5.6 5 6 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000601823697379354 0.0017196689184153 1.23865631642177 0.916666666666667 5.6 5 6 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.000601823697379354 0.0017196689184153 1.23865631642177 0.916666666666667 5.6 5 6 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000601823697379354 0.0017196689184153 1.23865631642177 0.916666666666667 5.6 5 6 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.000601823697379354 0.0017196689184153 1.23865631642177 0.916666666666667 5.6 5 6 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.000601823697379354 0.0017196689184153 1.23865631642177 0.916666666666667 5.6 5 6 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.000601823697379354 0.0017196689184153 1.23865631642177 0.916666666666667 5.6 5 6 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000601823697379354 0.0017196689184153 1.23865631642177 0.916666666666667 5.6 5 6 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.000601823697379354 0.0017196689184153 1.23865631642177 0.916666666666667 5.6 5 6 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 1.71647314402274e-09 1.11024603815653e-08 1.23543902728821 0.914285714285714 5.6 5 6 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 1.71647314402274e-09 1.11024603815653e-08 1.23543902728821 0.914285714285714 5.6 5 6 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.18137321662057e-11 1.94005880453192e-10 1.22841948736044 0.909090909090909 5.6 5 6 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 3.04918174383969e-06 1.31878085036241e-05 1.22841948736044 0.909090909090909 5.6 5 6 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 3.04918174383969e-06 1.31878085036241e-05 1.22841948736044 0.909090909090909 5.6 5 6 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00130445632906099 0.00342479955028374 1.22841948736044 0.909090909090909 5.6 5 6 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00130445632906099 0.00342479955028374 1.22841948736044 0.909090909090909 5.6 5 6 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.00130445632906099 0.00342479955028374 1.22841948736044 0.909090909090909 5.6 5 6 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00130445632906099 0.00342479955028374 1.22841948736044 0.909090909090909 5.6 5 6 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 6.54508008314592e-06 2.69180605731695e-05 1.22256987075396 0.904761904761905 5.6 5 6 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 6.54508008314592e-06 2.69180605731695e-05 1.22256987075396 0.904761904761905 5.6 5 6 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 1.39866959800181e-05 5.48293894753877e-05 1.21613529248683 0.9 5.6 5 6 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00280679102874507 0.00681580824898332 1.21613529248683 0.9 5.6 5 6 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 3.50200435600196e-07 1.74243083866811e-06 1.20648342508614 0.892857142857143 5.6 5 6 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 4.32133455250746e-09 2.6278884906915e-08 1.20517911868064 0.891891891891892 5.6 5 6 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.15127374337285e-10 9.52478219081147e-10 1.2011212765302 0.888888888888889 5.6 5 6 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00598676059216927 0.0133320192842831 1.2011212765302 0.888888888888889 5.6 5 6 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.00598676059216927 0.0133320192842831 1.2011212765302 0.888888888888889 5.6 5 6 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.00598676059216927 0.0133320192842831 1.2011212765302 0.888888888888889 5.6 5 6 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00598676059216927 0.0133320192842831 1.2011212765302 0.888888888888889 5.6 5 6 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.00598676059216927 0.0133320192842831 1.2011212765302 0.888888888888889 5.6 5 6 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00598676059216927 0.0133320192842831 1.2011212765302 0.888888888888889 5.6 5 6 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.00598676059216927 0.0133320192842831 1.2011212765302 0.888888888888889 5.6 5 6 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 7.38397343023201e-07 3.58614136219118e-06 1.2011212765302 0.888888888888889 5.6 5 6 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 3.99236689624474e-08 2.16837331807491e-07 1.19228950243807 0.882352941176471 5.6 5 6 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000132264002562898 0.0004377015712721 1.19228950243807 0.882352941176471 5.6 5 6 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000132264002562898 0.0004377015712721 1.19228950243807 0.882352941176471 5.6 5 6 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000132264002562898 0.0004377015712721 1.19228950243807 0.882352941176471 5.6 5 6 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 8.31883736661345e-08 4.41705431816826e-07 1.18747217111509 0.878787878787879 5.6 5 6 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 2.19233454118378e-09 1.38652980093534e-08 1.18647345608471 0.878048780487805 5.6 5 6 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 2.19233454118378e-09 1.38652980093534e-08 1.18647345608471 0.878048780487805 5.6 5 6 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.000276216177549222 0.000869592081089698 1.18235375658442 0.875 5.6 5 6 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000276216177549222 0.000869592081089698 1.18235375658442 0.875 5.6 5 6 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0126343913000741 0.0261699255021914 1.18235375658442 0.875 5.6 5 6 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 6.74024347329727e-06 2.75613978807529e-05 1.18235375658442 0.875 5.6 5 6 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 1.39452230960057e-05 5.48178244906524e-05 1.17500994443172 0.869565217391304 5.6 5 6 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.61545981081497e-12 2.05249938463367e-11 1.17109324461695 0.866666666666667 5.6 5 6 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.61545981081497e-12 2.05249938463367e-11 1.17109324461695 0.866666666666667 5.6 5 6 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.61545981081497e-12 2.05249938463367e-11 1.17109324461695 0.866666666666667 5.6 5 6 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.61545981081497e-12 2.05249938463367e-11 1.17109324461695 0.866666666666667 5.6 5 6 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.61545981081497e-12 2.05249938463367e-11 1.17109324461695 0.866666666666667 5.6 5 6 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.61545981081497e-12 2.05249938463367e-11 1.17109324461695 0.866666666666667 5.6 5 6 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.61545981081497e-12 2.05249938463367e-11 1.17109324461695 0.866666666666667 5.6 5 6 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 7.34635496215201e-07 3.58009010655558e-06 1.17109324461695 0.866666666666667 5.6 5 6 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00057250400659929 0.00166259837018528 1.17109324461695 0.866666666666667 5.6 5 6 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00057250400659929 0.00166259837018528 1.17109324461695 0.866666666666667 5.6 5 6 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 3.9665053364338e-08 2.16258126197138e-07 1.16865853932668 0.864864864864865 5.6 5 6 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.05166006959847e-14 2.30232658313635e-13 1.16615712978189 0.863013698630137 5.6 5 6 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 5.96426063581329e-16 1.5431168881386e-14 1.16546298863321 0.8625 5.6 5 6 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 6.90359542547143e-17 2.18307028676574e-15 1.16271332873418 0.86046511627907 5.6 5 6 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 4.43846109725251e-09 2.68762984740013e-08 1.16271332873418 0.86046511627907 5.6 5 6 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.56604645869542e-12 2.05249938463367e-11 1.1582240880827 0.857142857142857 5.6 5 6 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 3.0675787875612e-06 1.31878085036241e-05 1.1582240880827 0.857142857142857 5.6 5 6 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 3.0675787875612e-06 1.31878085036241e-05 1.1582240880827 0.857142857142857 5.6 5 6 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 5.86363913612509e-05 0.000211775596210812 1.1582240880827 0.857142857142857 5.6 5 6 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00117650285944041 0.0031351377696324 1.1582240880827 0.857142857142857 5.6 5 6 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00117650285944041 0.0031351377696324 1.1582240880827 0.857142857142857 5.6 5 6 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00117650285944041 0.0031351377696324 1.1582240880827 0.857142857142857 5.6 5 6 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00117650285944041 0.0031351377696324 1.1582240880827 0.857142857142857 5.6 5 6 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00117650285944041 0.0031351377696324 1.1582240880827 0.857142857142857 5.6 5 6 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0263133826121762 0.0490746310054086 1.1582240880827 0.857142857142857 5.6 5 6 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.78910750725983e-13 3.18237497853842e-12 1.15542644535786 0.855072463768116 5.6 5 6 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.78910750725983e-13 3.18237497853842e-12 1.15542644535786 0.855072463768116 5.6 5 6 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 6.39893252731001e-12 7.38192511469792e-11 1.1518949947052 0.852459016393443 5.6 5 6 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 6.21929032639742e-06 2.58018954357537e-05 1.15107455667478 0.851851851851852 5.6 5 6 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 6.21929032639742e-06 2.58018954357537e-05 1.15107455667478 0.851851851851852 5.6 5 6 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 2.03993319256333e-09 1.30171521659983e-08 1.15000973284807 0.851063829787234 5.6 5 6 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000119031680519975 0.00040233273486918 1.14857222068201 0.85 5.6 5 6 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000119031680519975 0.00040233273486918 1.14857222068201 0.85 5.6 5 6 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.000119031680519975 0.00040233273486918 1.14857222068201 0.85 5.6 5 6 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000119031680519975 0.00040233273486918 1.14857222068201 0.85 5.6 5 6 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.25365450164041e-05 4.95541765509528e-05 1.14337506131241 0.846153846153846 5.6 5 6 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.25365450164041e-05 4.95541765509528e-05 1.14337506131241 0.846153846153846 5.6 5 6 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 1.25365450164041e-05 4.95541765509528e-05 1.14337506131241 0.846153846153846 5.6 5 6 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 1.25365450164041e-05 4.95541765509528e-05 1.14337506131241 0.846153846153846 5.6 5 6 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00239420821322963 0.00601936093184764 1.14337506131241 0.846153846153846 5.6 5 6 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00239420821322963 0.00601936093184764 1.14337506131241 0.846153846153846 5.6 5 6 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.47932672956518e-16 6.78477295417548e-15 1.14106521270369 0.844444444444444 5.6 5 6 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.35199283978405e-06 6.14660003518433e-06 1.1401268367064 0.84375 5.6 5 6 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.18758789921131e-10 6.63651653836431e-09 1.13929885788527 0.843137254901961 5.6 5 6 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 9.18758789921131e-10 6.63651653836431e-09 1.13929885788527 0.843137254901961 5.6 5 6 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00023979879133678 0.000765097937381699 1.13790436723914 0.842105263157895 5.6 5 6 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00023979879133678 0.000765097937381699 1.13790436723914 0.842105263157895 5.6 5 6 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 8.61850862307536e-15 1.91627152666191e-13 1.13703706208118 0.841463414634146 5.6 5 6 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.1669530858092e-11 1.10326489751644e-10 1.13677549385894 0.841269841269841 5.6 5 6 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.1669530858092e-11 1.10326489751644e-10 1.13677549385894 0.841269841269841 5.6 5 6 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.511357912002e-05 9.47921036811366e-05 1.13505960632104 0.84 5.6 5 6 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 2.511357912002e-05 9.47921036811366e-05 1.13505960632104 0.84 5.6 5 6 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.511357912002e-05 9.47921036811366e-05 1.13505960632104 0.84 5.6 5 6 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 2.511357912002e-05 9.47921036811366e-05 1.13505960632104 0.84 5.6 5 6 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 2.94860598125565e-07 1.48263827255364e-06 1.13213795997273 0.837837837837838 5.6 5 6 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 2.94860598125565e-07 1.48263827255364e-06 1.13213795997273 0.837837837837838 5.6 5 6 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 6.65494935213643e-19 2.55945754813247e-17 1.1301459283716 0.836363636363636 5.6 5 6 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 4.5949238588426e-11 3.93890159706809e-10 1.12974316788394 0.836065573770492 5.6 5 6 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 4.5949238588426e-11 3.93890159706809e-10 1.12974316788394 0.836065573770492 5.6 5 6 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 5.20046723012542e-12 6.1668873903904e-11 1.12941254360303 0.835820895522388 5.6 5 6 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.20046723012542e-12 6.1668873903904e-11 1.12941254360303 0.835820895522388 5.6 5 6 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 5.9041785254797e-13 9.76935586250886e-12 1.12913626851898 0.835616438356164 5.6 5 6 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 7.66429742030256e-15 1.73115797287151e-13 1.12870072897471 0.835294117647059 5.6 5 6 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.31510472478694e-18 4.92472111413637e-17 1.12811734573192 0.834862385321101 5.6 5 6 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 1.98879814999898e-21 1.13202390697942e-19 1.12782450571832 0.834645669291339 5.6 5 6 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.16546928665968e-12 1.64204237120468e-11 1.12605119674707 0.833333333333333 5.6 5 6 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.16546928665968e-12 1.64204237120468e-11 1.12605119674707 0.833333333333333 5.6 5 6 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 9.07633107013902e-11 7.59742300753401e-10 1.12605119674707 0.833333333333333 5.6 5 6 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 9.07633107013902e-11 7.59742300753401e-10 1.12605119674707 0.833333333333333 5.6 5 6 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 7.18458862053996e-09 4.24218655893293e-08 1.12605119674707 0.833333333333333 5.6 5 6 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 6.45080645900375e-08 3.45093894404599e-07 1.12605119674707 0.833333333333333 5.6 5 6 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 5.84290053773098e-07 2.87697144124262e-06 1.12605119674707 0.833333333333333 5.6 5 6 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.35647411440738e-06 2.24184196023579e-05 1.12605119674707 0.833333333333333 5.6 5 6 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 4.99701212095478e-05 0.000181860569005592 1.12605119674707 0.833333333333333 5.6 5 6 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 4.99701212095478e-05 0.000181860569005592 1.12605119674707 0.833333333333333 5.6 5 6 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000479033627854616 0.00141718264539942 1.12605119674707 0.833333333333333 5.6 5 6 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00481761948746916 0.0110929976224411 1.12605119674707 0.833333333333333 5.6 5 6 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00481761948746916 0.0110929976224411 1.12605119674707 0.833333333333333 5.6 5 6 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.00481761948746916 0.0110929976224411 1.12605119674707 0.833333333333333 5.6 5 6 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00481761948746916 0.0110929976224411 1.12605119674707 0.833333333333333 5.6 5 6 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00481761948746916 0.0110929976224411 1.12605119674707 0.833333333333333 5.6 5 6 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00481761948746916 0.0110929976224411 1.12605119674707 0.833333333333333 5.6 5 6 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00481761948746916 0.0110929976224411 1.12605119674707 0.833333333333333 5.6 5 6 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 NADE MODULATES DEATH SIGNALLING%REACTOME%REACT_210754.1 NADE MODULATES DEATH SIGNALLING 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%REACT_196645.2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0538854360783208 0.090210559458177 1.12605119674707 0.833333333333333 5.6 5 6 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 3.57335164814042e-47 1.01697587906076e-44 1.12528256111789 0.832764505119454 5.6 5 6 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.16534705677773e-42 1.4566126945421e-39 1.12346257330627 0.831417624521073 5.6 5 6 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 8.75517335526358e-17 2.70839384446524e-15 1.12154699196008 0.83 5.6 5 6 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.42826295684254e-21 1.87631468753344e-19 1.12081374932034 0.829457364341085 5.6 5 6 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.7916968737845e-27 1.69972310093022e-25 1.12075213229179 0.829411764705882 5.6 5 6 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 1.27113742587111e-07 6.57755838914395e-07 1.12055826408001 0.829268292682927 5.6 5 6 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 1.27113742587111e-07 6.57755838914395e-07 1.12055826408001 0.829268292682927 5.6 5 6 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 4.50456874155116e-12 5.52586320623043e-11 1.11961661847994 0.828571428571429 5.6 5 6 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 3.51512172292352e-27 3.1262613823251e-25 1.11938817191424 0.828402366863905 5.6 5 6 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.30921545950216e-14 2.73972588069349e-13 1.11828532642467 0.827586206896552 5.6 5 6 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.30921545950216e-14 2.73972588069349e-13 1.11828532642467 0.827586206896552 5.6 5 6 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.50734727264794e-10 2.71247563531414e-09 1.11828532642467 0.827586206896552 5.6 5 6 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 3.50734727264794e-10 2.71247563531414e-09 1.11828532642467 0.827586206896552 5.6 5 6 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.50734727264794e-10 2.71247563531414e-09 1.11828532642467 0.827586206896552 5.6 5 6 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 3.50734727264794e-10 2.71247563531414e-09 1.11828532642467 0.827586206896552 5.6 5 6 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.51356636692657e-21 8.97418725056882e-20 1.11758464639558 0.827067669172932 5.6 5 6 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.00402290405174e-12 1.44315615400568e-11 1.11704278717309 0.826666666666667 5.6 5 6 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.00402290405174e-12 1.44315615400568e-11 1.11704278717309 0.826666666666667 5.6 5 6 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.00402290405174e-12 1.44315615400568e-11 1.11704278717309 0.826666666666667 5.6 5 6 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.00402290405174e-12 1.44315615400568e-11 1.11704278717309 0.826666666666667 5.6 5 6 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.00402290405174e-12 1.44315615400568e-11 1.11704278717309 0.826666666666667 5.6 5 6 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.35994777546528e-16 9.02114280091905e-15 1.11685894207974 0.826530612244898 5.6 5 6 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 2.77637779021945e-08 1.57359510296318e-07 1.11625944721013 0.826086956521739 5.6 5 6 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 9.87033652951305e-05 0.000338445515216797 1.11625944721013 0.826086956521739 5.6 5 6 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.28707039947661e-25 1.62725058922761e-23 1.1147906847796 0.825 5.6 5 6 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.49315927250729e-07 1.26255005152238e-06 1.1147906847796 0.825 5.6 5 6 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000947992994152067 0.0025992177855075 1.11280353560887 0.823529411764706 5.6 5 6 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000947992994152067 0.0025992177855075 1.11280353560887 0.823529411764706 5.6 5 6 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000947992994152067 0.0025992177855075 1.11280353560887 0.823529411764706 5.6 5 6 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.000947992994152067 0.0025992177855075 1.11280353560887 0.823529411764706 5.6 5 6 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000947992994152067 0.0025992177855075 1.11280353560887 0.823529411764706 5.6 5 6 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 4.35514081325187e-19 1.7214903825715e-17 1.11280353560887 0.823529411764706 5.6 5 6 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 6.08409000452248e-09 3.61787306996005e-08 1.11280353560887 0.823529411764706 5.6 5 6 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.12548196324446e-20 5.52262356447197e-19 1.11219210509479 0.823076923076923 5.6 5 6 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 4.36365025271337e-13 7.30526389366014e-12 1.11179738413001 0.822784810126582 5.6 5 6 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.28750801109793e-17 1.08793579064939e-15 1.11131781660271 0.822429906542056 5.6 5 6 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 5.42339280966058e-08 2.93440607153879e-07 1.11103718079044 0.822222222222222 5.6 5 6 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.95188404167018e-25 1.46185841647193e-23 1.11085295973576 0.822085889570552 5.6 5 6 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 9.71558906485528e-14 1.81911621569593e-12 1.10996475107925 0.821428571428571 5.6 5 6 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 9.71558906485528e-14 1.81911621569593e-12 1.10996475107925 0.821428571428571 5.6 5 6 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.33693320202126e-09 9.32576444351103e-09 1.10996475107925 0.821428571428571 5.6 5 6 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 2.07171634050438e-05 7.90362561002074e-05 1.10996475107925 0.821428571428571 5.6 5 6 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 3.34973961703199e-11 2.92434323621873e-10 1.10924446246726 0.82089552238806 5.6 5 6 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 3.34973961703199e-11 2.92434323621873e-10 1.10924446246726 0.82089552238806 5.6 5 6 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.41823816867044e-12 7.38192511469792e-11 1.10728367680128 0.819444444444444 5.6 5 6 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.22208571763793e-63 7.90506994049693e-61 1.10701934553444 0.81924882629108 5.6 5 6 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.07536554585105e-15 2.63835374438974e-14 1.10557753862439 0.818181818181818 5.6 5 6 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 2.59602495452628e-09 1.59919632480126e-08 1.10557753862439 0.818181818181818 5.6 5 6 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.59602495452628e-09 1.59919632480126e-08 1.10557753862439 0.818181818181818 5.6 5 6 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.59602495452628e-09 1.59919632480126e-08 1.10557753862439 0.818181818181818 5.6 5 6 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 2.59602495452628e-09 1.59919632480126e-08 1.10557753862439 0.818181818181818 5.6 5 6 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.59602495452628e-09 1.59919632480126e-08 1.10557753862439 0.818181818181818 5.6 5 6 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 2.59602495452628e-09 1.59919632480126e-08 1.10557753862439 0.818181818181818 5.6 5 6 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 4.40397299317294e-06 1.86513499085866e-05 1.10557753862439 0.818181818181818 5.6 5 6 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000193414189442497 0.000628375323234413 1.10557753862439 0.818181818181818 5.6 5 6 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00956729717732341 0.0203501702291946 1.10557753862439 0.818181818181818 5.6 5 6 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.00956729717732341 0.0203501702291946 1.10557753862439 0.818181818181818 5.6 5 6 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00956729717732341 0.0203501702291946 1.10557753862439 0.818181818181818 5.6 5 6 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00956729717732341 0.0203501702291946 1.10557753862439 0.818181818181818 5.6 5 6 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00956729717732341 0.0203501702291946 1.10557753862439 0.818181818181818 5.6 5 6 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00956729717732341 0.0203501702291946 1.10557753862439 0.818181818181818 5.6 5 6 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00956729717732341 0.0203501702291946 1.10557753862439 0.818181818181818 5.6 5 6 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00956729717732341 0.0203501702291946 1.10557753862439 0.818181818181818 5.6 5 6 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.43651366759431e-11 1.31979030503963e-10 1.10384737033234 0.816901408450704 5.6 5 6 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 3.18004616765919e-12 3.93496147528611e-11 1.10234485576292 0.815789473684211 5.6 5 6 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 7.04838763143197e-13 1.12695006736266e-11 1.10102783681935 0.814814814814815 5.6 5 6 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 7.04838763143197e-13 1.12695006736266e-11 1.10102783681935 0.814814814814815 5.6 5 6 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 5.02168482338519e-09 3.01512974838697e-08 1.10102783681935 0.814814814814815 5.6 5 6 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 4.4770163119885e-31 5.30899517663303e-29 1.10031288367856 0.814285714285714 5.6 5 6 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.04140234406512e-07 1.03746983414453e-06 1.09986395961341 0.813953488372093 5.6 5 6 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.10136754671358e-09 7.75864365828426e-09 1.0993313378412 0.813559322033898 5.6 5 6 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.10136754671358e-09 7.75864365828426e-09 1.0993313378412 0.813559322033898 5.6 5 6 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.98806271708578e-16 5.54708479688838e-15 1.09868920505041 0.813084112149533 5.6 5 6 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 2.42189882753565e-10 1.9253419170856e-09 1.09789991682839 0.8125 5.6 5 6 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 2.42189882753565e-10 1.9253419170856e-09 1.09789991682839 0.8125 5.6 5 6 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00185641793248292 0.00470888185013048 1.09789991682839 0.8125 5.6 5 6 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00185641793248292 0.00470888185013048 1.09789991682839 0.8125 5.6 5 6 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00185641793248292 0.00470888185013048 1.09789991682839 0.8125 5.6 5 6 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.00185641793248292 0.00470888185013048 1.09789991682839 0.8125 5.6 5 6 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00185641793248292 0.00470888185013048 1.09789991682839 0.8125 5.6 5 6 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00185641793248292 0.00470888185013048 1.09789991682839 0.8125 5.6 5 6 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00185641793248292 0.00470888185013048 1.09789991682839 0.8125 5.6 5 6 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.00811807908065e-13 5.09589526968067e-12 1.09690634224302 0.811764705882353 5.6 5 6 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.00811807908065e-13 5.09589526968067e-12 1.09690634224302 0.811764705882353 5.6 5 6 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.00811807908065e-13 5.09589526968067e-12 1.09690634224302 0.811764705882353 5.6 5 6 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.00811807908065e-13 5.09589526968067e-12 1.09690634224302 0.811764705882353 5.6 5 6 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 9.67533946539018e-09 5.61959512622458e-08 1.09630644815375 0.811320754716981 5.6 5 6 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.17846988350316e-11 1.10326489751644e-10 1.09561738061877 0.810810810810811 5.6 5 6 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.17846988350316e-11 1.10326489751644e-10 1.09561738061877 0.810810810810811 5.6 5 6 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.60606938219436e-12 3.25301467619524e-11 1.09469280898955 0.810126582278481 5.6 5 6 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 3.9318787407467e-07 1.94949945926221e-06 1.09387830541144 0.80952380952381 5.6 5 6 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000375711659444553 0.00116478799867015 1.09387830541144 0.80952380952381 5.6 5 6 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 8.52342728369537e-08 4.49216186099945e-07 1.09250924620566 0.808510638297872 5.6 5 6 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 8.52342728369537e-08 4.49216186099945e-07 1.09250924620566 0.808510638297872 5.6 5 6 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 6.30530743644478e-15 1.44716975517112e-13 1.09192843320928 0.808080808080808 5.6 5 6 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 4.98981034624814e-12 6.01737298534839e-11 1.09140346761639 0.807692307692308 5.6 5 6 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 7.79371223552065e-05 0.00027383833360854 1.09140346761639 0.807692307692308 5.6 5 6 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 5.42470000502067e-14 1.04315514961411e-12 1.08972696459393 0.806451612903226 5.6 5 6 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 8.90283939164241e-10 6.49678997656777e-09 1.08972696459393 0.806451612903226 5.6 5 6 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 3.50359557885427e-06 1.49269955350587e-05 1.0885161568555 0.805555555555556 5.6 5 6 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 3.50359557885427e-06 1.49269955350587e-05 1.0885161568555 0.805555555555556 5.6 5 6 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 3.50359557885427e-06 1.49269955350587e-05 1.0885161568555 0.805555555555556 5.6 5 6 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.54688539853057e-08 1.95628601632132e-07 1.08630821333246 0.803921568627451 5.6 5 6 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 7.7468548511377e-09 4.55527869965659e-08 1.08583508257753 0.803571428571429 5.6 5 6 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.62503929614841e-71 5.15843091841919e-68 1.08409187458691 0.802281368821293 5.6 5 6 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 3.10402031380449e-07 1.55528905159993e-06 1.08100914887718 0.8 5.6 5 6 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 6.68634252324258e-06 2.74197850448824e-05 1.08100914887718 0.8 5.6 5 6 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000722867234603994 0.00204095252944739 1.08100914887718 0.8 5.6 5 6 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0187066388458662 0.0361678628772657 1.08100914887718 0.8 5.6 5 6 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0187066388458662 0.0361678628772657 1.08100914887718 0.8 5.6 5 6 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0187066388458662 0.0361678628772657 1.08100914887718 0.8 5.6 5 6 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0187066388458662 0.0361678628772657 1.08100914887718 0.8 5.6 5 6 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0187066388458662 0.0361678628772657 1.08100914887718 0.8 5.6 5 6 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0187066388458662 0.0361678628772657 1.08100914887718 0.8 5.6 5 6 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0187066388458662 0.0361678628772657 1.08100914887718 0.8 5.6 5 6 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.47011952474181e-35 3.90553342634177e-33 1.08100914887718 0.8 5.6 5 6 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 9.06408619905054e-16 2.26284116864016e-14 1.08100914887718 0.8 5.6 5 6 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.83512590347405e-14 3.73054880091938e-13 1.08100914887718 0.8 5.6 5 6 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.83512590347405e-14 3.73054880091938e-13 1.08100914887718 0.8 5.6 5 6 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 3.44003484906423e-11 2.98485950623073e-10 1.08100914887718 0.8 5.6 5 6 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 7.08301052679328e-10 5.24954373938897e-09 1.08100914887718 0.8 5.6 5 6 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 6.74620890179182e-08 3.59545141095497e-07 1.08100914887718 0.8 5.6 5 6 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00359249827080489 0.00844979345347994 1.08100914887718 0.8 5.6 5 6 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.43757903922097e-11 1.31979030503963e-10 1.07758823384909 0.79746835443038 5.6 5 6 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.43757903922097e-11 1.31979030503963e-10 1.07758823384909 0.79746835443038 5.6 5 6 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.94962808062259e-10 2.33184486595886e-09 1.07709244906241 0.797101449275362 5.6 5 6 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.55228127324902e-24 3.08471250087303e-22 1.07642860163618 0.796610169491525 5.6 5 6 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 6.10182387062834e-09 3.61787306996005e-08 1.07642860163618 0.796610169491525 5.6 5 6 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.78668985205005e-08 1.57359510296318e-07 1.07600447689164 0.796296296296296 5.6 5 6 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.27715829708432e-07 6.58476904619925e-07 1.07549379607679 0.795918367346939 5.6 5 6 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 5.55965657563204e-10 4.27642773358075e-09 1.07306055219426 0.794117647058823 5.6 5 6 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 5.96213863070832e-05 0.000213705875856371 1.07169010449031 0.793103448275862 5.6 5 6 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 5.96213863070832e-05 0.000213705875856371 1.07169010449031 0.793103448275862 5.6 5 6 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 5.96213863070832e-05 0.000213705875856371 1.07169010449031 0.793103448275862 5.6 5 6 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000283889692820346 0.000885910159831912 1.06974863690971 0.791666666666667 5.6 5 6 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.000283889692820346 0.000885910159831912 1.06974863690971 0.791666666666667 5.6 5 6 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000283889692820346 0.000885910159831912 1.06974863690971 0.791666666666667 5.6 5 6 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 4.6860661005092e-12 5.69937782993554e-11 1.06843927505303 0.790697674418605 5.6 5 6 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 4.74074796939956e-09 2.85851032222694e-08 1.06793242530206 0.790322580645161 5.6 5 6 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.11324166149464e-11 1.8912848328974e-10 1.06766335691574 0.790123456790123 5.6 5 6 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 9.56451840954824e-21 4.8608248917097e-19 1.06723833169403 0.789808917197452 5.6 5 6 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 5.12409549174344e-06 2.15727452211566e-05 1.06678534428669 0.789473684210526 5.6 5 6 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 9.84749273344502e-08 5.15183167635745e-07 1.06541767076838 0.788461538461538 5.6 5 6 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 8.7603076567597e-12 8.48021618746194e-11 1.06511195551134 0.788235294117647 5.6 5 6 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 8.7603076567597e-12 8.48021618746194e-11 1.06511195551134 0.788235294117647 5.6 5 6 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.38775663978907e-20 6.58259232806614e-19 1.06231244976138 0.786163522012579 5.6 5 6 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.97763077252197e-18 1.03345575348751e-16 1.06170541407581 0.785714285714286 5.6 5 6 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 2.0741775103376e-06 9.19487413461186e-06 1.06170541407581 0.785714285714286 5.6 5 6 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000112255240559529 0.00038306764344415 1.0617054140758 0.785714285714286 5.6 5 6 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00685912784379011 0.0152270497998648 1.0617054140758 0.785714285714286 5.6 5 6 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.58044984438843e-20 1.18450971889185e-18 1.06048365870863 0.784810126582278 5.6 5 6 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.13781158530007e-19 8.94737025259413e-18 1.05789546641764 0.782894736842105 5.6 5 6 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.49557591576662e-09 9.80739413887511e-09 1.05750894998855 0.782608695652174 5.6 5 6 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 8.40848980324996e-07 4.05602745424566e-06 1.05750894998855 0.782608695652174 5.6 5 6 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 8.40848980324996e-07 4.05602745424566e-06 1.05750894998855 0.782608695652174 5.6 5 6 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000534373156373016 0.00155822336376804 1.05750894998855 0.782608695652174 5.6 5 6 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.000534373156373016 0.00155822336376804 1.05750894998855 0.782608695652174 5.6 5 6 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000534373156373016 0.00155822336376804 1.05750894998855 0.782608695652174 5.6 5 6 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000534373156373016 0.00155822336376804 1.05750894998855 0.782608695652174 5.6 5 6 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 4.46327633594064e-05 0.000163691809949575 1.05567299695037 0.78125 5.6 5 6 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 5.61782126878853e-11 4.78692195538089e-10 1.0546430720753 0.780487804878049 5.6 5 6 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.41342728520252e-07 1.70431825503269e-06 1.05398392015525 0.78 5.6 5 6 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.3524523062964e-33 8.21776330169071e-31 1.05318906048696 0.779411764705882 5.6 5 6 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 1.13475106560478e-09 7.9544372726877e-09 1.05098111696393 0.777777777777778 5.6 5 6 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.78259568286015e-05 6.81890767932796e-05 1.05098111696393 0.777777777777778 5.6 5 6 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.78259568286015e-05 6.81890767932796e-05 1.05098111696393 0.777777777777778 5.6 5 6 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.035901098777741 0.0634624392058701 1.05098111696393 0.777777777777778 5.6 5 6 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.38744235990938e-07 7.10190819478793e-07 1.05098111696393 0.777777777777778 5.6 5 6 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000209553420814911 0.000671609274368511 1.05098111696393 0.777777777777778 5.6 5 6 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000209553420814911 0.000671609274368511 1.05098111696393 0.777777777777778 5.6 5 6 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000209553420814911 0.000671609274368511 1.05098111696393 0.777777777777778 5.6 5 6 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 5.1062423157777e-09 3.05301798964356e-08 1.04874021905995 0.776119402985075 5.6 5 6 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.06349684795748e-26 8.90209420378524e-25 1.04828801993135 0.775784753363229 5.6 5 6 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 6.30607504291502e-07 3.09432578829934e-06 1.04791703207482 0.775510204081633 5.6 5 6 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.75119671611287e-11 1.57718539685355e-10 1.0476071807939 0.775280898876405 5.6 5 6 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 7.14607750551475e-06 2.90539094009928e-05 1.04722761297477 0.775 5.6 5 6 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 7.14607750551475e-06 2.90539094009928e-05 1.04722761297477 0.775 5.6 5 6 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 8.27908645993726e-05 0.000285538406211724 1.04613788601018 0.774193548387097 5.6 5 6 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 8.27908645993726e-05 0.000285538406211724 1.04613788601018 0.774193548387097 5.6 5 6 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.87366954912787e-06 1.25052959278561e-05 1.04415656425637 0.772727272727273 5.6 5 6 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.87366954912787e-06 1.25052959278561e-05 1.04415656425637 0.772727272727273 5.6 5 6 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000995523057451549 0.00270866025000679 1.04415656425637 0.772727272727273 5.6 5 6 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000995523057451549 0.00270866025000679 1.04415656425637 0.772727272727273 5.6 5 6 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000995523057451549 0.00270866025000679 1.04415656425637 0.772727272727273 5.6 5 6 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 4.63399312264975e-14 9.03311262127479e-13 1.04307900330255 0.771929824561403 5.6 5 6 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.77196748956435e-15 4.27374531805097e-14 1.04270567509807 0.771653543307087 5.6 5 6 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.79338473429428e-17 2.18307028676574e-15 1.04240167927443 0.771428571428571 5.6 5 6 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 3.29005213437629e-05 0.000121920421542121 1.04240167927443 0.771428571428571 5.6 5 6 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.95484682662354e-26 3.91708168571405e-24 1.04222855160805 0.771300448430493 5.6 5 6 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.15865306935064e-06 5.28449781309605e-06 1.04159735699104 0.770833333333333 5.6 5 6 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.23941712257263e-16 3.5273811308417e-15 1.04017966663542 0.76978417266187 5.6 5 6 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 9.12515538808924e-13 1.38502755697484e-11 1.03943187392037 0.769230769230769 5.6 5 6 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.71516194134805e-08 9.80190940778425e-08 1.03943187392037 0.769230769230769 5.6 5 6 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 1.31357491051675e-05 5.17788669713391e-05 1.03943187392037 0.769230769230769 5.6 5 6 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000387593513609169 0.00119124313145971 1.03943187392037 0.769230769230769 5.6 5 6 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000387593513609169 0.00119124313145971 1.03943187392037 0.769230769230769 5.6 5 6 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000387593513609169 0.00119124313145971 1.03943187392037 0.769230769230769 5.6 5 6 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000387593513609169 0.00119124313145971 1.03943187392037 0.769230769230769 5.6 5 6 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0128956570682675 0.0264036259109996 1.03943187392037 0.769230769230769 5.6 5 6 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0128956570682675 0.0264036259109996 1.03943187392037 0.769230769230769 5.6 5 6 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0128956570682675 0.0264036259109996 1.03943187392037 0.769230769230769 5.6 5 6 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0128956570682675 0.0264036259109996 1.03943187392037 0.769230769230769 5.6 5 6 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0128956570682675 0.0264036259109996 1.03943187392037 0.769230769230769 5.6 5 6 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0128956570682675 0.0264036259109996 1.03943187392037 0.769230769230769 5.6 5 6 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0128956570682675 0.0264036259109996 1.03943187392037 0.769230769230769 5.6 5 6 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0128956570682675 0.0264036259109996 1.03943187392037 0.769230769230769 5.6 5 6 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.0690799064543e-10 8.89649536189752e-10 1.03701459049265 0.767441860465116 5.6 5 6 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000152298586174158 0.000502832687066883 1.0359671010073 0.766666666666667 5.6 5 6 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 7.16668768709385e-21 3.77710984397576e-19 1.03375191832518 0.765027322404372 5.6 5 6 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.94093370298794e-10 1.56042297138522e-09 1.03331756877966 0.764705882352941 5.6 5 6 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.94093370298794e-10 1.56042297138522e-09 1.03331756877966 0.764705882352941 5.6 5 6 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.94093370298794e-10 1.56042297138522e-09 1.03331756877966 0.764705882352941 5.6 5 6 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.94093370298794e-10 1.56042297138522e-09 1.03331756877966 0.764705882352941 5.6 5 6 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.94093370298794e-10 1.56042297138522e-09 1.03331756877966 0.764705882352941 5.6 5 6 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 6.0264323504308e-05 0.000213855691637482 1.03331756877966 0.764705882352941 5.6 5 6 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 6.0264323504308e-05 0.000213855691637482 1.03331756877966 0.764705882352941 5.6 5 6 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 6.0264323504308e-05 0.000213855691637482 1.03331756877966 0.764705882352941 5.6 5 6 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 6.0264323504308e-05 0.000213855691637482 1.03331756877966 0.764705882352941 5.6 5 6 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00480879898205819 0.0110929976224411 1.03331756877966 0.764705882352941 5.6 5 6 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00480879898205819 0.0110929976224411 1.03331756877966 0.764705882352941 5.6 5 6 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00480879898205819 0.0110929976224411 1.03331756877966 0.764705882352941 5.6 5 6 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.93740211575065e-14 3.88299043762419e-13 1.03267134140707 0.764227642276423 5.6 5 6 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 9.58317783251896e-06 3.88514588480754e-05 1.02953252274017 0.761904761904762 5.6 5 6 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00183376507511421 0.00470888185013048 1.02953252274017 0.761904761904762 5.6 5 6 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00183376507511421 0.00470888185013048 1.02953252274017 0.761904761904762 5.6 5 6 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00183376507511421 0.00470888185013048 1.02953252274017 0.761904761904762 5.6 5 6 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00183376507511421 0.00470888185013048 1.02953252274017 0.761904761904762 5.6 5 6 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 9.14916306083172e-13 1.38502755697484e-11 1.02894219445879 0.761467889908257 5.6 5 6 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 3.84400900993617e-06 1.6328432301908e-05 1.02813370137776 0.760869565217391 5.6 5 6 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 1.54661262756713e-06 6.96465116781021e-06 1.02695869143332 0.76 5.6 5 6 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.000709785469787185 0.00200800143838402 1.02695869143332 0.76 5.6 5 6 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000709785469787185 0.00200800143838402 1.02695869143332 0.76 5.6 5 6 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000709785469787185 0.00200800143838402 1.02695869143332 0.76 5.6 5 6 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.13166404353952e-20 1.39261185436148e-18 1.02636797605142 0.759562841530055 5.6 5 6 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.64786357671655e-12 2.07514147758199e-11 1.02595775703622 0.759259259259259 5.6 5 6 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 6.33065510058081e-10 4.79176713198218e-09 1.02565627077203 0.759036144578313 5.6 5 6 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.000277675925352932 0.000872257928868041 1.02509488255595 0.758620689655172 5.6 5 6 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000109501085117989 0.000374567413756968 1.0236829061337 0.757575757575758 5.6 5 6 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.68377816912266e-08 9.6613561881514e-08 1.02309794447305 0.757142857142857 5.6 5 6 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.21234688649873e-12 1.69134276420363e-11 1.02257622191085 0.756756756756757 5.6 5 6 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.73266101099061e-05 6.66372059091796e-05 1.02168547607295 0.75609756097561 5.6 5 6 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.73266101099061e-05 6.66372059091796e-05 1.02168547607295 0.75609756097561 5.6 5 6 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.73266101099061e-05 6.66372059091796e-05 1.02168547607295 0.75609756097561 5.6 5 6 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 1.73266101099061e-05 6.66372059091796e-05 1.02168547607295 0.75609756097561 5.6 5 6 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.73266101099061e-05 6.66372059091796e-05 1.02168547607295 0.75609756097561 5.6 5 6 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.12264457185805e-06 5.15330072823874e-06 1.01981995177093 0.754716981132076 5.6 5 6 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.03484230178244e-09 1.30171521659983e-08 1.01761663706031 0.753086419753086 5.6 5 6 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 5.65445492120055e-11 4.78945794813594e-10 1.01692870963962 0.752577319587629 5.6 5 6 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 8.90590298903311e-09 5.19389342352218e-08 1.01344607707236 0.75 5.6 5 6 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 8.90590298903311e-09 5.19389342352218e-08 1.01344607707236 0.75 5.6 5 6 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000197265168319271 0.000636526835642455 1.01344607707236 0.75 5.6 5 6 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00880073928577081 0.0190615707818141 1.01344607707236 0.75 5.6 5 6 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00880073928577081 0.0190615707818141 1.01344607707236 0.75 5.6 5 6 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00880073928577081 0.0190615707818141 1.01344607707236 0.75 5.6 5 6 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00880073928577081 0.0190615707818141 1.01344607707236 0.75 5.6 5 6 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00880073928577081 0.0190615707818141 1.01344607707236 0.75 5.6 5 6 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00880073928577081 0.0190615707818141 1.01344607707236 0.75 5.6 5 6 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00880073928577081 0.0190615707818141 1.01344607707236 0.75 5.6 5 6 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0673503565484828 0.110541588660313 1.01344607707236 0.75 5.6 5 6 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0673503565484828 0.110541588660313 1.01344607707236 0.75 5.6 5 6 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0673503565484828 0.110541588660313 1.01344607707236 0.75 5.6 5 6 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0673503565484828 0.110541588660313 1.01344607707236 0.75 5.6 5 6 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0673503565484828 0.110541588660313 1.01344607707236 0.75 5.6 5 6 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0673503565484828 0.110541588660313 1.01344607707236 0.75 5.6 5 6 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0673503565484828 0.110541588660313 1.01344607707236 0.75 5.6 5 6 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0673503565484828 0.110541588660313 1.01344607707236 0.75 5.6 5 6 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 6.03402082939011e-10 4.59166397872841e-09 1.01344607707236 0.75 5.6 5 6 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 6.03402082939011e-10 4.59166397872841e-09 1.01344607707236 0.75 5.6 5 6 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.0087463951849e-06 8.93264412608784e-06 1.01344607707236 0.75 5.6 5 6 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 2.0087463951849e-06 8.93264412608784e-06 1.01344607707236 0.75 5.6 5 6 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.0087463951849e-06 8.93264412608784e-06 1.01344607707236 0.75 5.6 5 6 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 4.9909826493946e-06 2.10746834127256e-05 1.01344607707236 0.75 5.6 5 6 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000501447961581057 0.0014742984490286 1.01344607707236 0.75 5.6 5 6 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.000501447961581057 0.0014742984490286 1.01344607707236 0.75 5.6 5 6 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00128582354703102 0.00340097938183111 1.01344607707236 0.75 5.6 5 6 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00128582354703102 0.00340097938183111 1.01344607707236 0.75 5.6 5 6 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00333605535537402 0.00797849877428105 1.01344607707236 0.75 5.6 5 6 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00333605535537402 0.00797849877428105 1.01344607707236 0.75 5.6 5 6 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00333605535537402 0.00797849877428105 1.01344607707236 0.75 5.6 5 6 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00333605535537402 0.00797849877428105 1.01344607707236 0.75 5.6 5 6 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00333605535537402 0.00797849877428105 1.01344607707236 0.75 5.6 5 6 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0238163302468862 0.0451273474584808 1.01344607707236 0.75 5.6 5 6 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0238163302468862 0.0451273474584808 1.01344607707236 0.75 5.6 5 6 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0238163302468862 0.0451273474584808 1.01344607707236 0.75 5.6 5 6 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0238163302468862 0.0451273474584808 1.01344607707236 0.75 5.6 5 6 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0238163302468862 0.0451273474584808 1.01344607707236 0.75 5.6 5 6 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0238163302468862 0.0451273474584808 1.01344607707236 0.75 5.6 5 6 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.24936132932724e-19 9.14526049037905e-18 1.01163957782624 0.748663101604278 5.6 5 6 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.07108928500752e-09 7.62080026282854e-09 1.00956314191116 0.747126436781609 5.6 5 6 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 6.10117363379074e-13 9.97927595503934e-12 1.00790812036705 0.745901639344262 5.6 5 6 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 5.82531074259589e-07 2.87697144124262e-06 1.0077203930211 0.745762711864407 5.6 5 6 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.1620335956181e-22 2.57503208981068e-20 1.00730397963556 0.745454545454545 5.6 5 6 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 7.77368664612139e-13 1.20238653232943e-11 1.00254880742642 0.741935483870968 5.6 5 6 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 7.77368664612139e-13 1.20238653232943e-11 1.00254880742642 0.741935483870968 5.6 5 6 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 7.77368664612139e-13 1.20238653232943e-11 1.00254880742642 0.741935483870968 5.6 5 6 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000352133285701665 0.00109407350557526 1.00254880742642 0.741935483870968 5.6 5 6 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000896279493021334 0.00248133408281976 1.0009343971085 0.740740740740741 5.6 5 6 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.000896279493021334 0.00248133408281976 1.0009343971085 0.740740740740741 5.6 5 6 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000896279493021334 0.00248133408281976 1.0009343971085 0.740740740740741 5.6 5 6 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.36463839051547e-12 1.8853208055374e-11 0.999713745404712 0.739837398373984 5.6 5 6 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 9.78335671729994e-10 6.995837491818e-09 0.998758452766963 0.739130434782609 5.6 5 6 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.57012647020885e-05 6.12134237563616e-05 0.998758452766963 0.739130434782609 5.6 5 6 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.57012647020885e-05 6.12134237563616e-05 0.998758452766963 0.739130434782609 5.6 5 6 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.00230211444384072 0.00580834903117968 0.998758452766963 0.739130434782609 5.6 5 6 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 1.20985648770384e-07 6.30632154579694e-07 0.998758452766963 0.739130434782609 5.6 5 6 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00598627300810375 0.0133320192842831 0.995666321334248 0.736842105263158 5.6 5 6 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00598627300810375 0.0133320192842831 0.995666321334248 0.736842105263158 5.6 5 6 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00598627300810375 0.0133320192842831 0.995666321334248 0.736842105263158 5.6 5 6 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 7.00690818515382e-10 5.22033002485544e-09 0.995666321334248 0.736842105263158 5.6 5 6 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 7.00690818515382e-10 5.22033002485544e-09 0.995666321334248 0.736842105263158 5.6 5 6 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 7.00690818515382e-10 5.22033002485544e-09 0.995666321334248 0.736842105263158 5.6 5 6 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.48581915938222e-13 2.74587099194922e-12 0.991573140157128 0.733812949640288 5.6 5 6 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.000622463608094561 0.00177153142863712 0.990925053137418 0.733333333333333 5.6 5 6 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000622463608094561 0.00177153142863712 0.990925053137418 0.733333333333333 5.6 5 6 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0158423591694995 0.0310947270319969 0.990925053137418 0.733333333333333 5.6 5 6 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0158423591694995 0.0310947270319969 0.990925053137418 0.733333333333333 5.6 5 6 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0158423591694995 0.0310947270319969 0.990925053137418 0.733333333333333 5.6 5 6 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 6.86815469792697e-05 0.000241915448889853 0.988727880070594 0.731707317073171 5.6 5 6 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.04285143116587e-22 6.745352666132e-21 0.987669001484173 0.730923694779116 5.6 5 6 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.00158430649369894 0.00412151396806873 0.98746028022435 0.730769230769231 5.6 5 6 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00158430649369894 0.00412151396806873 0.98746028022435 0.730769230769231 5.6 5 6 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.54942318866388e-11 1.4043498073049e-10 0.982735589888349 0.727272727272727 5.6 5 6 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.54942318866388e-11 1.4043498073049e-10 0.982735589888349 0.727272727272727 5.6 5 6 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 4.8035718080095e-05 0.000175719349172173 0.982735589888348 0.727272727272727 5.6 5 6 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00406907712221464 0.00955494512361623 0.982735589888348 0.727272727272727 5.6 5 6 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0430782166286468 0.074034181476527 0.982735589888348 0.727272727272727 5.6 5 6 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.84435255117514e-07 9.40685906925527e-07 0.981052823467307 0.726027397260274 5.6 5 6 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.35497428624314e-14 6.63073390183887e-13 0.97879834794168 0.724358974358974 5.6 5 6 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.52620149904201e-18 5.42946183284195e-17 0.978055896603166 0.723809523809524 5.6 5 6 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 1.52620149904201e-18 5.42946183284195e-17 0.978055896603166 0.723809523809524 5.6 5 6 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.000298412148373141 0.00092919143793212 0.975911037180791 0.722222222222222 5.6 5 6 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0105793643173073 0.0224024336659648 0.975911037180791 0.722222222222222 5.6 5 6 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0105793643173073 0.0224024336659648 0.975911037180791 0.722222222222222 5.6 5 6 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 9.15579486736368e-08 4.80763693588875e-07 0.97496078300632 0.721518987341772 5.6 5 6 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 8.30730148781827e-05 0.000285538406211724 0.97416522137188 0.720930232558139 5.6 5 6 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 8.30730148781827e-05 0.000285538406211724 0.97416522137188 0.720930232558139 5.6 5 6 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0027670643170866 0.00681580824898332 0.972908233989465 0.72 5.6 5 6 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.89446859333245e-06 8.50419182432829e-06 0.971219157194344 0.71875 5.6 5 6 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 5.76758294644286e-05 0.000208836400325399 0.96938320415617 0.717391304347826 5.6 5 6 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.08136238734151e-30 2.27829129014382e-28 0.968283595919402 0.716577540106952 5.6 5 6 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.21973217740982e-14 2.62981649765785e-13 0.966309050231784 0.715116279069767 5.6 5 6 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00709178105602353 0.0156701932340396 0.965186740068914 0.714285714285714 5.6 5 6 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00709178105602353 0.0156701932340396 0.965186740068914 0.714285714285714 5.6 5 6 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 4.0013709418814e-05 0.000147511680059514 0.965186740068914 0.714285714285714 5.6 5 6 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0279869801294611 0.0516543096293426 0.965186740068914 0.714285714285714 5.6 5 6 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0279869801294611 0.0516543096293426 0.965186740068914 0.714285714285714 5.6 5 6 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0279869801294611 0.0516543096293426 0.965186740068914 0.714285714285714 5.6 5 6 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0279869801294611 0.0516543096293426 0.965186740068914 0.714285714285714 5.6 5 6 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.122815569743682 0.182810204754455 0.965186740068914 0.714285714285714 5.6 5 6 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.77435594015555e-69 2.68545425142067e-66 0.964531635946695 0.713800904977376 5.6 5 6 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.69108977511606e-13 3.08515480767968e-12 0.962773773218741 0.7125 5.6 5 6 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 2.30294220461662e-11 2.03545761314872e-10 0.962261931765675 0.712121212121212 5.6 5 6 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00128327106283275 0.00340097938183111 0.958959728842663 0.709677419354839 5.6 5 6 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00477024947894998 0.0110929976224411 0.957143517235006 0.708333333333333 5.6 5 6 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 9.3728971743237e-12 9.01191397233961e-11 0.954387447872338 0.706293706293706 5.6 5 6 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000875381578269429 0.00245210233440432 0.953831601950456 0.705882352941177 5.6 5 6 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000875381578269429 0.00245210233440432 0.953831601950456 0.705882352941177 5.6 5 6 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000875381578269429 0.00245210233440432 0.953831601950456 0.705882352941177 5.6 5 6 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0183813960146811 0.0358802833043775 0.953831601950456 0.705882352941177 5.6 5 6 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0183813960146811 0.0358802833043775 0.953831601950456 0.705882352941177 5.6 5 6 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0183813960146811 0.0358802833043775 0.953831601950456 0.705882352941177 5.6 5 6 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.83217912626158e-09 1.17972438763359e-08 0.953121905818052 0.705357142857143 5.6 5 6 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00321837062030826 0.00777545227962421 0.950887677253078 0.703703703703704 5.6 5 6 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00321837062030826 0.00777545227962421 0.950887677253078 0.703703703703704 5.6 5 6 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00321837062030826 0.00777545227962421 0.950887677253078 0.703703703703704 5.6 5 6 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000408690092736008 0.00125067957411471 0.945883005267535 0.7 5.6 5 6 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000408690092736008 0.00125067957411471 0.945883005267535 0.7 5.6 5 6 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0121701141978065 0.0255806093108989 0.945883005267535 0.7 5.6 5 6 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0121701141978065 0.0255806093108989 0.945883005267535 0.7 5.6 5 6 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0121701141978065 0.0255806093108989 0.945883005267535 0.7 5.6 5 6 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.076021505285449 0.121351094893205 0.945883005267535 0.7 5.6 5 6 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 8.12098969540788e-38 1.44452104207068e-35 0.943858643565518 0.698501872659176 5.6 5 6 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 5.42482862388487e-05 0.000196926814586433 0.943333455388108 0.69811320754717 5.6 5 6 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 1.47346652526998e-06 6.66976761798178e-06 0.942327054119913 0.697368421052632 5.6 5 6 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00147609803530483 0.00385410551236472 0.941788273643001 0.696969696969697 5.6 5 6 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00147609803530483 0.00385410551236472 0.941788273643001 0.696969696969697 5.6 5 6 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00147609803530483 0.00385410551236472 0.941788273643001 0.696969696969697 5.6 5 6 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 9.57709517503745e-10 6.88293254246378e-09 0.936307136822757 0.692913385826772 5.6 5 6 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.31144513678657e-08 1.83353557573825e-07 0.935488686528332 0.692307692307692 5.6 5 6 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00542826941970884 0.0124186935438033 0.935488686528332 0.692307692307692 5.6 5 6 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0483878448987783 0.0824621596298939 0.935488686528332 0.692307692307692 5.6 5 6 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0483878448987783 0.0824621596298939 0.935488686528332 0.692307692307692 5.6 5 6 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0483878448987783 0.0824621596298939 0.935488686528332 0.692307692307692 5.6 5 6 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0483878448987783 0.0824621596298939 0.935488686528332 0.692307692307692 5.6 5 6 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0483878448987783 0.0824621596298939 0.935488686528332 0.692307692307692 5.6 5 6 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0483878448987783 0.0824621596298939 0.935488686528332 0.692307692307692 5.6 5 6 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 6.18823153291316e-05 0.000219051081376503 0.933598810393931 0.690909090909091 5.6 5 6 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000465282389391439 0.00140274754259326 0.933013848733283 0.69047619047619 5.6 5 6 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 5.81725322711202e-06 2.42755171324938e-05 0.932560709418697 0.690140845070423 5.6 5 6 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 7.4931338155261e-12 7.4046732079817e-11 0.931052087066476 0.689024390243902 5.6 5 6 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00166460043918906 0.00430677531812006 0.926579270466157 0.685714285714286 5.6 5 6 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00166460043918906 0.00430677531812006 0.926579270466157 0.685714285714286 5.6 5 6 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 6.1518938081809e-08 3.31596397312175e-07 0.926579270466157 0.685714285714286 5.6 5 6 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00112861571205231 0.00303595493053013 0.924547298381801 0.684210526315789 5.6 5 6 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.221855355122e-16 3.5273811308417e-15 0.922289551621406 0.682539682539683 5.6 5 6 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.221855355122e-16 3.5273811308417e-15 0.922289551621406 0.682539682539683 5.6 5 6 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.221855355122e-16 3.5273811308417e-15 0.922289551621406 0.682539682539683 5.6 5 6 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0135690037713283 0.0275145694066262 0.921314615520327 0.681818181818182 5.6 5 6 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0135690037713283 0.0275145694066262 0.921314615520327 0.681818181818182 5.6 5 6 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 7.56783423018602e-10 5.57980731065011e-09 0.920007786278454 0.680851063829787 5.6 5 6 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00902701794790967 0.0194627977876901 0.918857776545606 0.68 5.6 5 6 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00902701794790967 0.0194627977876901 0.918857776545606 0.68 5.6 5 6 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00902701794790967 0.0194627977876901 0.918857776545606 0.68 5.6 5 6 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000166084395364728 0.000547078922694462 0.917837956593835 0.679245283018868 5.6 5 6 DISEASE%REACTOME%REACT_189085.2 DISEASE 7.80585241682925e-47 1.85128799819134e-44 0.915259026498127 0.677336747759283 5.6 5 6 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.51576614204134e-12 2.05249938463367e-11 0.914916597356991 0.677083333333333 5.6 5 6 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00273214153637885 0.00678505655543998 0.914088618535854 0.676470588235294 5.6 5 6 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 6.23320668520373e-20 2.68783427668028e-18 0.911894220678605 0.674846625766871 5.6 5 6 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.0801436188963e-12 7.92968577219961e-11 0.910632706934584 0.673913043478261 5.6 5 6 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000183755696978539 0.000603889969516077 0.909030420646722 0.672727272727273 5.6 5 6 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 3.16197555556798e-08 1.75761375608329e-07 0.908224899671404 0.672131147540984 5.6 5 6 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0339854594094287 0.0608318348926001 0.900840957397653 0.666666666666667 5.6 5 6 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0339854594094287 0.0608318348926001 0.900840957397653 0.666666666666667 5.6 5 6 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.130248872089966 0.192265710564338 0.900840957397653 0.666666666666667 5.6 5 6 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.130248872089966 0.192265710564338 0.900840957397653 0.666666666666667 5.6 5 6 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.130248872089966 0.192265710564338 0.900840957397653 0.666666666666667 5.6 5 6 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.130248872089966 0.192265710564338 0.900840957397653 0.666666666666667 5.6 5 6 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.130248872089966 0.192265710564338 0.900840957397653 0.666666666666667 5.6 5 6 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.130248872089966 0.192265710564338 0.900840957397653 0.666666666666667 5.6 5 6 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.130248872089966 0.192265710564338 0.900840957397653 0.666666666666667 5.6 5 6 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.130248872089966 0.192265710564338 0.900840957397653 0.666666666666667 5.6 5 6 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00202075765083133 0.00510752777465894 0.900840957397653 0.666666666666667 5.6 5 6 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00202075765083133 0.00510752777465894 0.900840957397653 0.666666666666667 5.6 5 6 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00984806701851002 0.020916118458716 0.900840957397653 0.666666666666667 5.6 5 6 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0223267804813723 0.0427604422947412 0.900840957397653 0.666666666666667 5.6 5 6 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0522762220493843 0.0888758231496702 0.900840957397653 0.666666666666667 5.6 5 6 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0522762220493843 0.0888758231496702 0.900840957397653 0.666666666666667 5.6 5 6 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0816019893921679 0.128026053919575 0.900840957397653 0.666666666666667 5.6 5 6 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0816019893921679 0.128026053919575 0.900840957397653 0.666666666666667 5.6 5 6 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0816019893921679 0.128026053919575 0.900840957397653 0.666666666666667 5.6 5 6 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.53165508359865e-09 9.99791368789396e-09 0.897935018825402 0.664516129032258 5.6 5 6 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 7.3950066632844e-16 1.87912401461673e-14 0.897588823977445 0.664259927797834 5.6 5 6 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 2.89689640329439e-08 1.61658179681879e-07 0.897402633132776 0.66412213740458 5.6 5 6 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 2.89689640329439e-08 1.61658179681879e-07 0.897402633132776 0.66412213740458 5.6 5 6 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.08258163568991e-05 4.37645928291688e-05 0.895414204642245 0.662650602409639 5.6 5 6 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 4.10702044668029e-09 2.50827901099831e-08 0.889217203108651 0.658064516129032 5.6 5 6 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.02057400238332e-06 4.71518443308915e-06 0.884462030899514 0.654545454545455 5.6 5 6 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 1.47644188310911e-06 6.66976761798178e-06 0.884002808661248 0.654205607476635 5.6 5 6 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000739304253360277 0.00208322762877559 0.883517092832313 0.653846153846154 5.6 5 6 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0158246540567335 0.0310947270319969 0.883517092832313 0.653846153846154 5.6 5 6 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0238086690453853 0.0451273474584808 0.881257458323791 0.652173913043478 5.6 5 6 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0238086690453853 0.0451273474584808 0.881257458323791 0.652173913043478 5.6 5 6 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.14817860371034e-08 6.64169980926755e-08 0.877889595425738 0.64968152866242 5.6 5 6 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.00509536214479443 0.0117135708110541 0.876493904495014 0.648648648648649 5.6 5 6 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00754562352898918 0.0166213967209777 0.874345635121251 0.647058823529412 5.6 5 6 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.055080222228575 0.0919943148254251 0.874345635121251 0.647058823529412 5.6 5 6 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.055080222228575 0.0919943148254251 0.874345635121251 0.647058823529412 5.6 5 6 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0112081673168665 0.0236635342609808 0.871781571675148 0.645161290322581 5.6 5 6 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0112081673168665 0.0236635342609808 0.871781571675148 0.645161290322581 5.6 5 6 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000197000617805043 0.000636526835642455 0.868668066062022 0.642857142857143 5.6 5 6 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000197000617805043 0.000636526835642455 0.868668066062022 0.642857142857143 5.6 5 6 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0851094014835491 0.132216897719531 0.868668066062022 0.642857142857143 5.6 5 6 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0851094014835491 0.132216897719531 0.868668066062022 0.642857142857143 5.6 5 6 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0851094014835491 0.132216897719531 0.868668066062022 0.642857142857143 5.6 5 6 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0851094014835491 0.132216897719531 0.868668066062022 0.642857142857143 5.6 5 6 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0851094014835491 0.132216897719531 0.868668066062022 0.642857142857143 5.6 5 6 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0851094014835491 0.132216897719531 0.868668066062022 0.642857142857143 5.6 5 6 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0851094014835491 0.132216897719531 0.868668066062022 0.642857142857143 5.6 5 6 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 6.82656047477471e-05 0.000241047036119216 0.867476477494036 0.641975308641975 5.6 5 6 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00538256944765959 0.0123339715362634 0.866193228266974 0.641025641025641 5.6 5 6 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0250159900859209 0.0472745735621054 0.864807319101747 0.64 5.6 5 6 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0250159900859209 0.0472745735621054 0.864807319101747 0.64 5.6 5 6 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 2.65810527044151e-28 2.70177414274162e-26 0.863714541579554 0.639191290824261 5.6 5 6 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000883084239924611 0.00245915630804838 0.862011605785685 0.637931034482759 5.6 5 6 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000883084239924611 0.00245915630804838 0.862011605785685 0.637931034482759 5.6 5 6 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000883084239924611 0.00245915630804838 0.862011605785685 0.637931034482759 5.6 5 6 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000438595741237228 0.00133931703815574 0.859893641152305 0.636363636363636 5.6 5 6 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.133672260434853 0.196098584122469 0.859893641152305 0.636363636363636 5.6 5 6 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.133672260434853 0.196098584122469 0.859893641152305 0.636363636363636 5.6 5 6 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.133672260434853 0.196098584122469 0.859893641152305 0.636363636363636 5.6 5 6 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.133672260434853 0.196098584122469 0.859893641152305 0.636363636363636 5.6 5 6 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.133672260434853 0.196098584122469 0.859893641152305 0.636363636363636 5.6 5 6 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.38020232994562e-09 2.07328789461751e-08 0.858614037519638 0.635416666666667 5.6 5 6 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0174496609973043 0.0342022969685455 0.85579890952777 0.633333333333333 5.6 5 6 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.00441100836062e-63 7.90506994049693e-61 0.854897487007456 0.632666236281472 5.6 5 6 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0027432813947641 0.0068008526563577 0.854879684061038 0.63265306122449 5.6 5 6 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00829730544628748 0.0182489422721284 0.853428275429355 0.631578947368421 5.6 5 6 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0570501404188808 0.0950612995504301 0.853428275429355 0.631578947368421 5.6 5 6 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0570501404188808 0.0950612995504301 0.853428275429355 0.631578947368421 5.6 5 6 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0259848520217134 0.0490403772240029 0.850794237542227 0.62962962962963 5.6 5 6 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000966921251143001 0.00264601719303171 0.849987032383269 0.629032258064516 5.6 5 6 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00860399571423809 0.0188942683662975 0.844538397560299 0.625 5.6 5 6 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0871800539421874 0.135285950664921 0.844538397560299 0.625 5.6 5 6 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.215257591735681 0.290758444259677 0.844538397560299 0.625 5.6 5 6 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.215257591735681 0.290758444259677 0.844538397560299 0.625 5.6 5 6 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.215257591735681 0.290758444259677 0.844538397560299 0.625 5.6 5 6 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.215257591735681 0.290758444259677 0.844538397560299 0.625 5.6 5 6 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.215257591735681 0.290758444259677 0.844538397560299 0.625 5.6 5 6 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.215257591735681 0.290758444259677 0.844538397560299 0.625 5.6 5 6 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.215257591735681 0.290758444259677 0.844538397560299 0.625 5.6 5 6 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00416351553668082 0.00976059737841319 0.844538397560299 0.625 5.6 5 6 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0388513709250378 0.0683380727148687 0.844538397560299 0.625 5.6 5 6 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0388513709250378 0.0683380727148687 0.844538397560299 0.625 5.6 5 6 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0388513709250378 0.0683380727148687 0.844538397560299 0.625 5.6 5 6 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0267474508406779 0.049818877678383 0.838713994818504 0.620689655172414 5.6 5 6 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 4.51411841722949e-35 6.42359050771757e-33 0.833210254890321 0.616616616616617 5.6 5 6 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0397221277326209 0.0696973955160537 0.831545499136295 0.615384615384615 5.6 5 6 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0397221277326209 0.0696973955160537 0.831545499136295 0.615384615384615 5.6 5 6 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.134744620581592 0.197062276554579 0.831545499136295 0.615384615384615 5.6 5 6 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.134744620581592 0.197062276554579 0.831545499136295 0.615384615384615 5.6 5 6 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.134744620581592 0.197062276554579 0.831545499136295 0.615384615384615 5.6 5 6 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0882291352300904 0.136578876459369 0.825770877614515 0.611111111111111 5.6 5 6 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0882291352300904 0.136578876459369 0.825770877614515 0.611111111111111 5.6 5 6 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0132342493073216 0.0270579551211474 0.823939900058829 0.609756097560976 5.6 5 6 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.06851931467707e-15 1.20208383079758e-13 0.821057957807502 0.60762331838565 5.6 5 6 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0403210729094057 0.0706611905789215 0.820408729058577 0.607142857142857 5.6 5 6 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00327333104089049 0.00789483062913078 0.819617592386389 0.60655737704918 5.6 5 6 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0277631288367562 0.0515756296797704 0.818946324906957 0.606060606060606 5.6 5 6 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.1385268879038e-16 1.09057847434946e-14 0.81844696739177 0.605691056910569 5.6 5 6 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.019267801140783 0.0372022809000464 0.817868763953132 0.605263157894737 5.6 5 6 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.18778492669392e-05 0.000153984959966032 0.817295223445451 0.604838709677419 5.6 5 6 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0134535379902564 0.0274668358108103 0.817041798569964 0.604651162790698 5.6 5 6 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0280620076629496 0.0517256954719913 0.810756861657888 0.6 5.6 5 6 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0885375456528837 0.1366474267506 0.810756861657888 0.6 5.6 5 6 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0885375456528837 0.1366474267506 0.810756861657888 0.6 5.6 5 6 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.211589922296742 0.289790625051265 0.810756861657888 0.6 5.6 5 6 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0406941356057381 0.071139748116665 0.810756861657887 0.6 5.6 5 6 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0406941356057381 0.071139748116665 0.810756861657887 0.6 5.6 5 6 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0596044421837133 0.0988544536450163 0.810756861657887 0.6 5.6 5 6 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.08034197938586e-17 1.04364919920621e-15 0.809336972232917 0.598949211908932 5.6 5 6 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 5.50225818929925e-15 1.28355957432342e-13 0.808027040574864 0.597979797979798 5.6 5 6 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.0001231831110649 0.00041537812096055 0.804056391726831 0.59504132231405 5.6 5 6 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0138376092068151 0.0275145694066262 0.7997261560571 0.591836734693878 5.6 5 6 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0883011710067603 0.136578876459369 0.798472666784283 0.590909090909091 5.6 5 6 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.00691440169348574 0.0153258467442838 0.797465765565135 0.590163934426229 5.6 5 6 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0197924964531547 0.0380090721360853 0.793131712491412 0.58695652173913 5.6 5 6 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0595503708401033 0.0988544536450163 0.792118772884143 0.586206896551724 5.6 5 6 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0283366348363574 0.0520969397572825 0.790982304056476 0.585365853658537 5.6 5 6 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 5.21731503609778e-06 2.19004109037379e-05 0.788807437315204 0.583756345177665 5.6 5 6 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0197863166521643 0.0380090721360853 0.788235837722946 0.583333333333333 5.6 5 6 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0197863166521643 0.0380090721360853 0.788235837722946 0.583333333333333 5.6 5 6 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0197863166521643 0.0380090721360853 0.788235837722946 0.583333333333333 5.6 5 6 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.206570639894611 0.287275445509639 0.788235837722946 0.583333333333333 5.6 5 6 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.206570639894611 0.287275445509639 0.788235837722946 0.583333333333333 5.6 5 6 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.206570639894611 0.287275445509639 0.788235837722946 0.583333333333333 5.6 5 6 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.206570639894611 0.287275445509639 0.788235837722946 0.583333333333333 5.6 5 6 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0591955181487639 0.0984056335580503 0.784603414507633 0.580645161290323 5.6 5 6 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00353019252040523 0.00842863079955812 0.784065277734994 0.580246913580247 5.6 5 6 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0281346289689038 0.0517924670410738 0.780728829744632 0.577777777777778 5.6 5 6 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0586794816807989 0.0976618741892127 0.777999008661609 0.575757575757576 5.6 5 6 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.200924912712315 0.280860658928903 0.772149392055131 0.571428571428571 5.6 5 6 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.200924912712315 0.280860658928903 0.772149392055131 0.571428571428571 5.6 5 6 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0842085246081192 0.131824786047694 0.765714813788005 0.566666666666667 5.6 5 6 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0268132722523524 0.0498761913922843 0.76162008216347 0.563636363636364 5.6 5 6 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.195018034953865 0.27314041706629 0.76008455780427 0.5625 5.6 5 6 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.195018034953865 0.27314041706629 0.76008455780427 0.5625 5.6 5 6 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.195018034953865 0.27314041706629 0.76008455780427 0.5625 5.6 5 6 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00632008643440415 0.0140523171814955 0.755544028785128 0.559139784946237 5.6 5 6 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.189046732840349 0.265823617422744 0.750700797831377 0.555555555555556 5.6 5 6 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.189046732840349 0.265823617422744 0.750700797831377 0.555555555555556 5.6 5 6 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.321518491292824 0.423238495013588 0.750700797831377 0.555555555555556 5.6 5 6 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.321518491292824 0.423238495013588 0.750700797831377 0.555555555555556 5.6 5 6 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.321518491292824 0.423238495013588 0.750700797831377 0.555555555555556 5.6 5 6 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.321518491292824 0.423238495013588 0.750700797831377 0.555555555555556 5.6 5 6 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0536439006311537 0.090210559458177 0.750700797831377 0.555555555555556 5.6 5 6 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.114581461023051 0.172539067762752 0.741014335923876 0.548387096774194 5.6 5 6 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00126029050331553 0.00335213717050094 0.738577679357082 0.546583850931677 5.6 5 6 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0152811662909786 0.030159638879421 0.737051692416261 0.545454545454545 5.6 5 6 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.111623896837149 0.168263564829728 0.737051692416261 0.545454545454545 5.6 5 6 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.111623896837149 0.168263564829728 0.737051692416261 0.545454545454545 5.6 5 6 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.111623896837149 0.168263564829728 0.737051692416261 0.545454545454545 5.6 5 6 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.177304915080399 0.255090680517001 0.737051692416261 0.545454545454545 5.6 5 6 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.30509111653101 0.403480166192963 0.737051692416261 0.545454545454545 5.6 5 6 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.30509111653101 0.403480166192963 0.737051692416261 0.545454545454545 5.6 5 6 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00161706139531935 0.00419904811229823 0.734018557879569 0.54320987654321 5.6 5 6 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0694080980873948 0.113787699975072 0.731933277885593 0.541666666666667 5.6 5 6 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.171633356160771 0.250240026451615 0.731933277885593 0.541666666666667 5.6 5 6 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000243024892554468 0.000773656425290846 0.730725068447023 0.540772532188841 5.6 5 6 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.290367662426467 0.385441402642596 0.727602311744258 0.538461538461538 5.6 5 6 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.290367662426467 0.385441402642596 0.727602311744258 0.538461538461538 5.6 5 6 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.290367662426467 0.385441402642596 0.727602311744258 0.538461538461538 5.6 5 6 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.277000046515193 0.369766478603301 0.720672765918122 0.533333333333333 5.6 5 6 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.150662641924331 0.220115954269326 0.717857637926255 0.53125 5.6 5 6 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0222461279413132 0.0426633963079363 0.716168561131134 0.53 5.6 5 6 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.264746748337984 0.353741429938921 0.715373701462842 0.529411764705882 5.6 5 6 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000497976983078919 0.00147016856207739 0.715373701462842 0.529411764705882 5.6 5 6 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00531785081381139 0.0122053253355703 0.712935481621455 0.52760736196319 5.6 5 6 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.009105440652441 0.0196021816163745 0.70614307305687 0.52258064516129 5.6 5 6 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00867204165128132 0.0189851004150359 0.705375466641558 0.522012578616352 5.6 5 6 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00867204165128132 0.0189851004150359 0.705375466641558 0.522012578616352 5.6 5 6 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.233112626838427 0.312647754939757 0.705005966659033 0.521739130434783 5.6 5 6 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0381489088833787 0.0673522299516723 0.704380961369441 0.521276595744681 5.6 5 6 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.223921566549508 0.30060414075467 0.702655946770169 0.52 5.6 5 6 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.223921566549508 0.30060414075467 0.702655946770169 0.52 5.6 5 6 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0912812650958847 0.140729404367762 0.696744177987247 0.515625 5.6 5 6 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.178641744597951 0.255090680517001 0.693891007725219 0.513513513513513 5.6 5 6 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.131320396230752 0.193646553198301 0.687914912921844 0.509090909090909 5.6 5 6 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0139216373666696 0.0275145694066262 0.686586891854427 0.508108108108108 5.6 5 6 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0445939448935485 0.0765466629475507 0.67563071804824 0.5 5.6 5 6 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.248206006500774 0.332264484713642 0.67563071804824 0.5 5.6 5 6 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.30853839250432 0.407660290189087 0.67563071804824 0.5 5.6 5 6 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.323742080699425 0.425771701326508 0.67563071804824 0.5 5.6 5 6 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.340446763835618 0.444047428907502 0.67563071804824 0.5 5.6 5 6 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.35898205807652 0.463250870293907 0.67563071804824 0.5 5.6 5 6 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.35898205807652 0.463250870293907 0.67563071804824 0.5 5.6 5 6 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.431447060288905 0.526994992953744 0.67563071804824 0.5 5.6 5 6 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.431447060288905 0.526994992953744 0.67563071804824 0.5 5.6 5 6 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.431447060288905 0.526994992953744 0.67563071804824 0.5 5.6 5 6 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.431447060288905 0.526994992953744 0.67563071804824 0.5 5.6 5 6 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0749553528442585 0.121351094893205 0.675630718048239 0.5 5.6 5 6 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.177000107012222 0.255090680517001 0.675630718048239 0.5 5.6 5 6 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.281716752884376 0.375358557448003 0.675630718048239 0.5 5.6 5 6 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.294591897516084 0.390684315158796 0.675630718048239 0.5 5.6 5 6 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.37981041214062 0.484726651548074 0.675630718048239 0.5 5.6 5 6 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.40361159316741 0.505135705432915 0.675630718048239 0.5 5.6 5 6 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.120303759246146 0.180773230630692 0.667682121365319 0.494117647058824 5.6 5 6 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.120303759246146 0.180773230630692 0.667682121365319 0.494117647058824 5.6 5 6 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0612308308211673 0.101433611476742 0.666114792441926 0.492957746478873 5.6 5 6 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.155652490066868 0.227172813707849 0.665838968511309 0.492753623188406 5.6 5 6 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.172111003262403 0.250679588170316 0.664906420936363 0.492063492063492 5.6 5 6 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.190832627593761 0.268069920104562 0.663777547556165 0.491228070175439 5.6 5 6 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0774778842363653 0.122094163087871 0.660835884806307 0.489051094890511 5.6 5 6 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.288666767761003 0.384258943427415 0.656326983246861 0.485714285714286 5.6 5 6 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.092022249006832 0.141718247117664 0.655759226340938 0.485294117647059 5.6 5 6 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.30097278101495 0.398774923076605 0.655157059925566 0.484848484848485 5.6 5 6 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.105542362737125 0.162364088837761 0.650972662645019 0.481751824817518 5.6 5 6 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0834057590767519 0.130711888949579 0.650912521046475 0.481707317073171 5.6 5 6 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.241672425772135 0.323822845455507 0.650607358120527 0.481481481481481 5.6 5 6 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.343407316169648 0.447498727939019 0.650607358120527 0.481481481481481 5.6 5 6 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.280264496864738 0.373773551113892 0.646255469437446 0.478260869565217 5.6 5 6 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.183426277719714 0.258431280391241 0.645602686134985 0.477777777777778 5.6 5 6 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.397215196069484 0.497567978879292 0.643457826712609 0.476190476190476 5.6 5 6 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.418760311986516 0.521280836395608 0.640071206572016 0.473684210526316 5.6 5 6 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.442746777844107 0.539870321227219 0.635887734633637 0.470588235294118 5.6 5 6 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.442746777844107 0.539870321227219 0.635887734633637 0.470588235294118 5.6 5 6 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0804440173427082 0.126628137918887 0.635887734633637 0.470588235294118 5.6 5 6 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.372286456222168 0.4755508323197 0.633403798170225 0.46875 5.6 5 6 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.253419065341346 0.338924182312721 0.632869280197085 0.468354430379747 5.6 5 6 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.407228303190995 0.509214301793309 0.627371381044794 0.464285714285714 5.6 5 6 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.366074812568199 0.46803635065997 0.62619432404471 0.463414634146341 5.6 5 6 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.50067781951679 0.603272258401687 0.623659124352221 0.461538461538462 5.6 5 6 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.50067781951679 0.603272258401687 0.623659124352221 0.461538461538462 5.6 5 6 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.50067781951679 0.603272258401687 0.623659124352221 0.461538461538462 5.6 5 6 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.536743680087151 0.636488547303347 0.614209743680218 0.454545454545455 5.6 5 6 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.536743680087151 0.636488547303347 0.614209743680218 0.454545454545455 5.6 5 6 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.536743680087151 0.636488547303347 0.614209743680218 0.454545454545455 5.6 5 6 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.536743680087151 0.636488547303347 0.614209743680218 0.454545454545455 5.6 5 6 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.536743680087151 0.636488547303347 0.614209743680218 0.454545454545455 5.6 5 6 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.536743680087151 0.636488547303347 0.614209743680218 0.454545454545455 5.6 5 6 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.524586789050898 0.625722548884684 0.600560638265102 0.444444444444444 5.6 5 6 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.408072745088307 0.509822226743337 0.597399792800549 0.442105263157895 5.6 5 6 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.50795490272883 0.606491828818095 0.589011395221542 0.435897435897436 5.6 5 6 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.221617947811718 0.298074045119163 0.585986056921839 0.433658536585366 5.6 5 6 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.534349164509161 0.636488547303347 0.585546622308474 0.433333333333333 5.6 5 6 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.558155684870033 0.660778319109865 0.579112044041348 0.428571428571429 5.6 5 6 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.591328375048917 0.684670689743376 0.579112044041348 0.428571428571429 5.6 5 6 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.591328375048917 0.684670689743376 0.579112044041348 0.428571428571429 5.6 5 6 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.591328375048917 0.684670689743376 0.579112044041348 0.428571428571429 5.6 5 6 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.591328375048917 0.684670689743376 0.579112044041348 0.428571428571429 5.6 5 6 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.591328375048917 0.684670689743376 0.579112044041348 0.428571428571429 5.6 5 6 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.591328375048917 0.684670689743376 0.579112044041348 0.428571428571429 5.6 5 6 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.543164367495476 0.643566107365581 0.575947497352598 0.426229508196721 5.6 5 6 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.601551499643176 0.695941287798569 0.56895218361957 0.421052631578947 5.6 5 6 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.631838027886966 0.729201552054463 0.563025598373533 0.416666666666667 5.6 5 6 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.631838027886966 0.729201552054463 0.563025598373533 0.416666666666667 5.6 5 6 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.627305391221179 0.725146687008723 0.556401767804433 0.411764705882353 5.6 5 6 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.645554452052853 0.742622461819895 0.550513918409677 0.407407407407407 5.6 5 6 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.671584165257688 0.76209271703484 0.540504574438592 0.4 5.6 5 6 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.672367637039615 0.762373822715038 0.540504574438592 0.4 5.6 5 6 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.742225732165367 0.834930606222386 0.50672303853618 0.375 5.6 5 6 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.813447127650799 0.895925125887838 0.491367794944174 0.363636363636364 5.6 5 6 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.994599150475215 1 0.491051191983514 0.36340206185567 5.6 5 6 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.781860259823554 0.875363611116379 0.482593370034457 0.357142857142857 5.6 5 6 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.781860259823554 0.875363611116379 0.482593370034457 0.357142857142857 5.6 5 6 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.781860259823554 0.875363611116379 0.482593370034457 0.357142857142857 5.6 5 6 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.835221828809038 0.917068412342022 0.479479864421331 0.354838709677419 5.6 5 6 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.835221828809038 0.917068412342022 0.479479864421331 0.354838709677419 5.6 5 6 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.918706206845279 0.991143997225801 0.478928103932929 0.354430379746835 5.6 5 6 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.817153549311194 0.899311292088035 0.472941502633768 0.35 5.6 5 6 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.995528840470516 1 0.460798830742578 0.341013824884793 5.6 5 6 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.90874622685573 0.983964879686544 0.460003893139227 0.340425531914894 5.6 5 6 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.920858392898166 0.992713252344007 0.458918978296917 0.339622641509434 5.6 5 6 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.998717890644602 1 0.458463701532734 0.339285714285714 5.6 5 6 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.836606571215523 0.917173459814861 0.450420478698826 0.333333333333333 5.6 5 6 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.836606571215523 0.917173459814861 0.450420478698826 0.333333333333333 5.6 5 6 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.886850526030249 0.966308202820683 0.450420478698826 0.333333333333333 5.6 5 6 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.975873330610838 1 0.450420478698826 0.333333333333333 5.6 5 6 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.940427360684652 1 0.441228224031503 0.326530612244898 5.6 5 6 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.885982068818201 0.966308202820683 0.426714137714678 0.315789473684211 5.6 5 6 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999208586800648 1 0.42226919878015 0.3125 5.6 5 6 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999948905880953 1 0.392301707253817 0.290322580645161 5.6 5 6 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.958225637610409 1 0.392301707253816 0.290322580645161 5.6 5 6 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.97069636241886 1 0.391154626238454 0.289473684210526 5.6 5 6 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.938080241997256 1 0.386074696027565 0.285714285714286 5.6 5 6 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.955718030017431 1 0.378353202107014 0.28 5.6 5 6 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.987508831677481 1 0.347467226424809 0.257142857142857 5.6 5 6 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.999150881789023 1 0.342573321827276 0.253521126760563 5.6 5 6 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.333560757525075 0.246851385390428 5.6 5 6 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.991568215645023 1 0.315294335089178 0.233333333333333 5.6 5 6 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.984916296818668 1 0.307104871840109 0.227272727272727 5.6 5 6 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.984916296818668 1 0.307104871840109 0.227272727272727 5.6 5 6 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.994081319094821 1 0.305123550086302 0.225806451612903 5.6 5 6 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.994591585502447 1 0.289556022020674 0.214285714285714 5.6 5 6 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.288334266653498 0.213381555153707 5.6 5 6 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999368370308031 1 0.287502433212017 0.212765957446809 5.6 5 6 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.999557804685004 1 0.281512799186766 0.208333333333333 5.6 5 6 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999872433490555 1 0.25336151926809 0.1875 5.6 5 6 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999999997829338 1 0.225210239349413 0.166666666666667 5.6 5 6 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.99999999094882 1 0.210196223392786 0.155555555555556 5.6 5 6 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0261534471502544 0.0193548387096774 5.6 5 6 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000212927247444202 0.000682422236741216 1.15636918382914 1 5.5 5 5 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 2.11199392246326e-06 9.98460914174491e-06 1.15636918382914 1 5.5 5 5 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 2.11199392246326e-06 9.98460914174491e-06 1.15636918382914 1 5.5 5 5 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.11199392246326e-06 9.98460914174491e-06 1.15636918382914 1 5.5 5 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 4.55672498873023e-06 1.92410078900983e-05 1.15636918382914 1 5.5 5 5 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 4.55672498873023e-06 1.92410078900983e-05 1.15636918382914 1 5.5 5 5 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 4.55672498873023e-06 1.92410078900983e-05 1.15636918382914 1 5.5 5 5 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 4.55672498873023e-06 1.92410078900983e-05 1.15636918382914 1 5.5 5 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 2.12094131946054e-05 8.00556895913089e-05 1.15636918382914 1 5.5 5 5 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 2.12094131946054e-05 8.00556895913089e-05 1.15636918382914 1 5.5 5 5 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 2.12094131946054e-05 8.00556895913089e-05 1.15636918382914 1 5.5 5 5 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 2.12094131946054e-05 8.00556895913089e-05 1.15636918382914 1 5.5 5 5 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 9.87063738705013e-05 0.000327410652721966 1.15636918382914 1 5.5 5 5 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 9.87063738705013e-05 0.000327410652721966 1.15636918382914 1 5.5 5 5 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 9.87063738705013e-05 0.000327410652721966 1.15636918382914 1 5.5 5 5 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 9.87063738705013e-05 0.000327410652721966 1.15636918382914 1 5.5 5 5 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 9.87063738705013e-05 0.000327410652721966 1.15636918382914 1 5.5 5 5 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 9.87063738705013e-05 0.000327410652721966 1.15636918382914 1 5.5 5 5 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000990738114065332 0.00272166088091693 1.15636918382914 1 5.5 5 5 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00213698002268124 0.00538216384473523 1.15636918382914 1 5.5 5 5 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00213698002268124 0.00538216384473523 1.15636918382914 1 5.5 5 5 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.00213698002268124 0.00538216384473523 1.15636918382914 1 5.5 5 5 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00213698002268124 0.00538216384473523 1.15636918382914 1 5.5 5 5 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00213698002268124 0.00538216384473523 1.15636918382914 1 5.5 5 5 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00460921789693352 0.0107876925449612 1.15636918382914 1 5.5 5 5 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00460921789693352 0.0107876925449612 1.15636918382914 1 5.5 5 5 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00460921789693352 0.0107876925449612 1.15636918382914 1 5.5 5 5 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00460921789693352 0.0107876925449612 1.15636918382914 1 5.5 5 5 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00460921789693352 0.0107876925449612 1.15636918382914 1 5.5 5 5 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00460921789693352 0.0107876925449612 1.15636918382914 1 5.5 5 5 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.00994120899327172 0.0215974662556117 1.15636918382914 1 5.5 5 5 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 9.8310102209616e-06 3.94215762491001e-05 1.15636918382914 1 5.5 5 5 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 9.8310102209616e-06 3.94215762491001e-05 1.15636918382914 1 5.5 5 5 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 4.5755608552851e-05 0.00016359354515253 1.15636918382914 1 5.5 5 5 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000459306364955011 0.00136165199443954 1.15636918382914 1 5.5 5 5 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.000459306364955011 0.00136165199443954 1.15636918382914 1 5.5 5 5 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000459306364955011 0.00136165199443954 1.15636918382914 1 5.5 5 5 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.000459306364955011 0.00136165199443954 1.15636918382914 1 5.5 5 5 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.000459306364955011 0.00136165199443954 1.15636918382914 1 5.5 5 5 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000459306364955011 0.00136165199443954 1.15636918382914 1 5.5 5 5 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000459306364955011 0.00136165199443954 1.15636918382914 1 5.5 5 5 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%REACT_208690.1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%REACT_199036.2 ACYL CHAIN REMODELING OF DAG AND TAG 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%REACT_209262.1 CLEAVAGE OF THE DAMAGED PYRIMIDINE 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 DEPYRIMIDINATION%REACTOME%REACT_206945.1 DEPYRIMIDINATION 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_199058.2 GRB7 EVENTS IN ERBB2 SIGNALING 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 48%5605497 NETRIN MEDIATED REPULSION SIGNALS 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%REACT_209347.1 NGF-INDEPENDANT TRKA ACTIVATION 0.0214405714912433 0.0417372547633915 1.15636918382914 1 5.5 5 5 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.33645374396262e-14 4.96234877262508e-13 1.13123072331111 0.978260869565217 5.5 5 5 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 4.9380211026928e-14 9.62575894401623e-13 1.13067209085516 0.977777777777778 5.5 5 5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.04310332258966e-13 1.85542003505637e-12 1.13008806601484 0.977272727272727 5.5 5 5 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 4.04840382888544e-11 4.02899803261751e-10 1.12424781761166 0.972222222222222 5.5 5 5 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.49396516659843e-08 9.12408769128568e-08 1.11507028440667 0.964285714285714 5.5 5 5 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.34562385060839e-07 7.30848373822803e-07 1.11011441647597 0.96 5.5 5 5 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 1.34562385060839e-07 7.30848373822803e-07 1.11011441647597 0.96 5.5 5 5 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 1.34562385060839e-07 7.30848373822803e-07 1.11011441647597 0.96 5.5 5 5 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 2.46647054697485e-06 1.14698940795595e-05 1.10130398459918 0.952380952380952 5.5 5 5 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.46647054697485e-06 1.14698940795595e-05 1.10130398459918 0.952380952380952 5.5 5 5 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 1.04323850171716e-05 4.12368996650979e-05 1.09550764783813 0.947368421052632 5.5 5 5 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 1.04323850171716e-05 4.12368996650979e-05 1.09550764783813 0.947368421052632 5.5 5 5 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 1.04323850171716e-05 4.12368996650979e-05 1.09550764783813 0.947368421052632 5.5 5 5 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 1.04323850171716e-05 4.12368996650979e-05 1.09550764783813 0.947368421052632 5.5 5 5 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 4.1188761476947e-10 3.50967710070033e-09 1.09386274146 0.945945945945946 5.5 5 5 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 2.13753816723874e-05 8.02563802633438e-05 1.09212645139419 0.944444444444444 5.5 5 5 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 2.13753816723874e-05 8.02563802633438e-05 1.09212645139419 0.944444444444444 5.5 5 5 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 4.36724220490018e-05 0.000156933981251842 1.08834746713331 0.941176470588235 5.5 5 5 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 4.36724220490018e-05 0.000156933981251842 1.08834746713331 0.941176470588235 5.5 5 5 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 7.13272836442974e-09 4.97542767773702e-08 1.08628620299101 0.939393939393939 5.5 5 5 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 8.8945288704432e-05 0.000299926885844566 1.08409610983982 0.9375 5.5 5 5 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 8.8945288704432e-05 0.000299926885844566 1.08409610983982 0.9375 5.5 5 5 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 8.8945288704432e-05 0.000299926885844566 1.08409610983982 0.9375 5.5 5 5 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 8.38876601137209e-15 1.86518969284101e-13 1.0792779049072 0.933333333333333 5.5 5 5 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 8.38876601137209e-15 1.86518969284101e-13 1.0792779049072 0.933333333333333 5.5 5 5 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 8.38876601137209e-15 1.86518969284101e-13 1.0792779049072 0.933333333333333 5.5 5 5 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 8.38876601137209e-15 1.86518969284101e-13 1.0792779049072 0.933333333333333 5.5 5 5 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 8.38876601137209e-15 1.86518969284101e-13 1.0792779049072 0.933333333333333 5.5 5 5 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 8.38876601137209e-15 1.86518969284101e-13 1.0792779049072 0.933333333333333 5.5 5 5 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 8.38876601137209e-15 1.86518969284101e-13 1.0792779049072 0.933333333333333 5.5 5 5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 5.94171677527071e-08 3.39560761895993e-07 1.0792779049072 0.933333333333333 5.5 5 5 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000180507054825619 0.000579822887171232 1.0792779049072 0.933333333333333 5.5 5 5 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.000180507054825619 0.000579822887171232 1.0792779049072 0.933333333333333 5.5 5 5 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000180507054825619 0.000579822887171232 1.0792779049072 0.933333333333333 5.5 5 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 1.19940918280643e-07 6.61534599664167e-07 1.07661958494437 0.931034482758621 5.5 5 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 2.41548777679639e-07 1.27305152088195e-06 1.0737713849842 0.928571428571429 5.5 5 5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000364856148210043 0.00113113354880804 1.0737713849842 0.928571428571429 5.5 5 5 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000364856148210043 0.00113113354880804 1.0737713849842 0.928571428571429 5.5 5 5 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000364856148210043 0.00113113354880804 1.0737713849842 0.928571428571429 5.5 5 5 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 4.85235669004024e-07 2.46603698925974e-06 1.0707122072492 0.925925925925926 5.5 5 5 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 4.85235669004024e-07 2.46603698925974e-06 1.0707122072492 0.925925925925926 5.5 5 5 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 4.85235669004024e-07 2.46603698925974e-06 1.0707122072492 0.925925925925926 5.5 5 5 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000734115557682307 0.00211039684562005 1.06741770814997 0.923076923076923 5.5 5 5 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.000734115557682307 0.00211039684562005 1.06741770814997 0.923076923076923 5.5 5 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000734115557682307 0.00211039684562005 1.06741770814997 0.923076923076923 5.5 5 5 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.000734115557682307 0.00211039684562005 1.06741770814997 0.923076923076923 5.5 5 5 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 3.86736750106831e-06 1.66765574364249e-05 1.06000508517671 0.916666666666667 5.5 5 5 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 3.86736750106831e-06 1.66765574364249e-05 1.06000508517671 0.916666666666667 5.5 5 5 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.00146935685675492 0.00382947766879533 1.06000508517671 0.916666666666667 5.5 5 5 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00146935685675492 0.00382947766879533 1.06000508517671 0.916666666666667 5.5 5 5 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00146935685675492 0.00382947766879533 1.06000508517671 0.916666666666667 5.5 5 5 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00146935685675492 0.00382947766879533 1.06000508517671 0.916666666666667 5.5 5 5 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.00146935685675492 0.00382947766879533 1.06000508517671 0.916666666666667 5.5 5 5 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00146935685675492 0.00382947766879533 1.06000508517671 0.916666666666667 5.5 5 5 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00146935685675492 0.00382947766879533 1.06000508517671 0.916666666666667 5.5 5 5 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00146935685675492 0.00382947766879533 1.06000508517671 0.916666666666667 5.5 5 5 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.13707396190063e-08 7.36976800357665e-08 1.06000508517671 0.916666666666667 5.5 5 5 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 2.25518948459065e-08 1.33713943190521e-07 1.05725182521521 0.914285714285714 5.5 5 5 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 7.67555260923352e-06 3.14764016223035e-05 1.05581534175704 0.91304347826087 5.5 5 5 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 7.67555260923352e-06 3.14764016223035e-05 1.05581534175704 0.91304347826087 5.5 5 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 7.67555260923352e-06 3.14764016223035e-05 1.05581534175704 0.91304347826087 5.5 5 5 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.77629813738658e-17 6.48121089615669e-16 1.05518688024409 0.9125 5.5 5 5 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 1.51777856030963e-05 5.88501060305341e-05 1.05124471257194 0.909090909090909 5.5 5 5 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0029230975400631 0.00712254760190033 1.05124471257194 0.909090909090909 5.5 5 5 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 3.40069460092383e-18 1.30169189725109e-16 1.04879995742643 0.906976744186046 5.5 5 5 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 1.60903833523692e-13 2.72578756076445e-12 1.04623878536922 0.904761904761905 5.5 5 5 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 2.98929145326991e-05 0.000110775045260497 1.04623878536922 0.904761904761905 5.5 5 5 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 2.98929145326991e-05 0.000110775045260497 1.04623878536922 0.904761904761905 5.5 5 5 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.98929145326991e-05 0.000110775045260497 1.04623878536922 0.904761904761905 5.5 5 5 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.04979902573882e-09 2.91053738061936e-08 1.04355267808971 0.902439024390244 5.5 5 5 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.04979902573882e-09 2.91053738061936e-08 1.04355267808971 0.902439024390244 5.5 5 5 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.04979902573882e-09 2.91053738061936e-08 1.04355267808971 0.902439024390244 5.5 5 5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.04979902573882e-09 2.91053738061936e-08 1.04355267808971 0.902439024390244 5.5 5 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.95301812106435e-11 4.76225999072606e-10 1.04299965600275 0.901960784313726 5.5 5 5 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 4.95301812106435e-11 4.76225999072606e-10 1.04299965600275 0.901960784313726 5.5 5 5 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.73323019701444e-15 1.86518969284101e-13 1.04236095443753 0.901408450704225 5.5 5 5 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.42742842819662e-18 9.59508514812165e-17 1.04073226544622 0.9 5.5 5 5 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 5.86172346897509e-05 0.000203942114825221 1.04073226544622 0.9 5.5 5 5 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.86172346897509e-05 0.000203942114825221 1.04073226544622 0.9 5.5 5 5 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 5.86172346897509e-05 0.000203942114825221 1.04073226544622 0.9 5.5 5 5 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 5.86172346897509e-05 0.000203942114825221 1.04073226544622 0.9 5.5 5 5 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 5.86172346897509e-05 0.000203942114825221 1.04073226544622 0.9 5.5 5 5 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 5.86172346897509e-05 0.000203942114825221 1.04073226544622 0.9 5.5 5 5 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.00577362385605822 0.0130826415713231 1.04073226544622 0.9 5.5 5 5 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.00577362385605822 0.0130826415713231 1.04073226544622 0.9 5.5 5 5 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.00577362385605822 0.0130826415713231 1.04073226544622 0.9 5.5 5 5 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00577362385605822 0.0130826415713231 1.04073226544622 0.9 5.5 5 5 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.10892834162987e-13 1.94815435819667e-12 1.03555449298132 0.895522388059702 5.5 5 5 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.09436097315187e-10 5.86934631674134e-09 1.03335118554944 0.893617021276596 5.5 5 5 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 2.51595976337388e-06 1.158644253489e-05 1.03247248556173 0.892857142857143 5.5 5 5 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 5.79918808359858e-08 3.32751800119386e-07 1.03135629909085 0.891891891891892 5.5 5 5 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.37223689850789e-09 1.05550978733877e-08 1.03067688123901 0.891304347826087 5.5 5 5 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.37223689850789e-09 1.05550978733877e-08 1.03067688123901 0.891304347826087 5.5 5 5 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.54769189282829e-12 2.22461168029763e-11 1.02788371895923 0.888888888888889 5.5 5 5 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 4.86742656707222e-06 2.04317050293326e-05 1.02788371895923 0.888888888888889 5.5 5 5 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 4.86742656707222e-06 2.04317050293326e-05 1.02788371895923 0.888888888888889 5.5 5 5 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 2.64764306954914e-09 1.98294530945707e-08 1.02788371895923 0.888888888888889 5.5 5 5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 1.12001136661109e-07 6.22568818237334e-07 1.02788371895923 0.888888888888889 5.5 5 5 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.12001136661109e-07 6.22568818237334e-07 1.02788371895923 0.888888888888889 5.5 5 5 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000222048745061917 0.000703731323436765 1.02788371895923 0.888888888888889 5.5 5 5 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0113069152916085 0.0240864378143097 1.02788371895923 0.888888888888889 5.5 5 5 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0113069152916085 0.0240864378143097 1.02788371895923 0.888888888888889 5.5 5 5 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0113069152916085 0.0240864378143097 1.02788371895923 0.888888888888889 5.5 5 5 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0113069152916085 0.0240864378143097 1.02788371895923 0.888888888888889 5.5 5 5 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.40150691926979e-13 2.43212725136696e-12 1.02421270567724 0.885714285714286 5.5 5 5 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.15618919613461e-07 1.1534801601878e-06 1.02421270567724 0.885714285714286 5.5 5 5 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 5.71728576802891e-12 6.72371706438441e-11 1.02367108076678 0.885245901639344 5.5 5 5 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 5.71728576802891e-12 6.72371706438441e-11 1.02367108076678 0.885245901639344 5.5 5 5 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 5.71728576802891e-12 6.72371706438441e-11 1.02367108076678 0.885245901639344 5.5 5 5 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 9.3776603464322e-06 3.79102575936734e-05 1.02294197031039 0.884615384615385 5.5 5 5 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 9.3776603464322e-06 3.79102575936734e-05 1.02294197031039 0.884615384615385 5.5 5 5 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 9.3776603464322e-06 3.79102575936734e-05 1.02294197031039 0.884615384615385 5.5 5 5 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 9.3776603464322e-06 3.79102575936734e-05 1.02294197031039 0.884615384615385 5.5 5 5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 1.09553625324752e-11 1.25721620029937e-10 1.02145944571574 0.883333333333333 5.5 5 5 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 6.0162398296055e-16 1.86111071250622e-14 1.02032575043747 0.882352941176471 5.5 5 5 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000428491788620159 0.00129770773932177 1.02032575043747 0.882352941176471 5.5 5 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.000428491788620159 0.00129770773932177 1.02032575043747 0.882352941176471 5.5 5 5 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.000428491788620159 0.00129770773932177 1.02032575043747 0.882352941176471 5.5 5 5 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 2.42589517551814e-14 5.07654240406222e-13 1.01943072784937 0.881578947368421 5.5 5 5 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.8712457859146e-08 1.12829777684597e-07 1.01870618575424 0.880952380952381 5.5 5 5 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.8712457859146e-08 1.12829777684597e-07 1.01870618575424 0.880952380952381 5.5 5 5 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.8712457859146e-08 1.12829777684597e-07 1.01870618575424 0.880952380952381 5.5 5 5 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.79866350490057e-05 6.91756261479326e-05 1.01760488176964 0.88 5.5 5 5 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.79866350490057e-05 6.91756261479326e-05 1.01760488176964 0.88 5.5 5 5 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 3.9968495248554e-11 4.02899803261751e-10 1.01680738578079 0.879310344827586 5.5 5 5 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 3.9968495248554e-11 4.02899803261751e-10 1.01680738578079 0.879310344827586 5.5 5 5 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 7.90887319026596e-07 3.86746616829844e-06 1.01620322215288 0.878787878787879 5.5 5 5 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 8.81899697730309e-14 1.60890162803876e-12 1.01572968849857 0.878378378378378 5.5 5 5 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 8.81899697730309e-14 1.60890162803876e-12 1.01572968849857 0.878378378378378 5.5 5 5 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.63880723923516e-09 1.24707096333242e-08 1.01477295723782 0.877551020408163 5.5 5 5 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 3.18279560988287e-13 5.20588293432567e-12 1.0118230358505 0.875 5.5 5 5 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 1.44503458370986e-10 1.35281856093364e-09 1.0118230358505 0.875 5.5 5 5 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.5062415608479e-06 7.24115453069785e-06 1.0118230358505 0.875 5.5 5 5 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 3.43328483663905e-05 0.000125385872536011 1.0118230358505 0.875 5.5 5 5 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 3.43328483663905e-05 0.000125385872536011 1.0118230358505 0.875 5.5 5 5 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 3.43328483663905e-05 0.000125385872536011 1.0118230358505 0.875 5.5 5 5 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.000821439417673925 0.00231466988386138 1.0118230358505 0.875 5.5 5 5 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000821439417673925 0.00231466988386138 1.0118230358505 0.875 5.5 5 5 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000821439417673925 0.00231466988386138 1.0118230358505 0.875 5.5 5 5 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.000821439417673925 0.00231466988386138 1.0118230358505 0.875 5.5 5 5 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000821439417673925 0.00231466988386138 1.0118230358505 0.875 5.5 5 5 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000821439417673925 0.00231466988386138 1.0118230358505 0.875 5.5 5 5 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000821439417673925 0.00231466988386138 1.0118230358505 0.875 5.5 5 5 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.000821439417673925 0.00231466988386138 1.0118230358505 0.875 5.5 5 5 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0219148830166995 0.0419151593182304 1.0118230358505 0.875 5.5 5 5 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 6.79030697883237e-08 3.83436779003114e-07 1.0118230358505 0.875 5.5 5 5 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 7.01286473467369e-21 3.56403804194309e-19 1.01060836233807 0.873949579831933 5.5 5 5 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.28082127838902e-11 1.45808694331806e-10 1.00952865254925 0.873015873015873 5.5 5 5 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 2.73775757752605e-10 2.43489314551223e-09 1.00919492406907 0.872727272727273 5.5 5 5 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.73775757752605e-10 2.43489314551223e-09 1.00919492406907 0.872727272727273 5.5 5 5 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.73775757752605e-10 2.43489314551223e-09 1.00919492406907 0.872727272727273 5.5 5 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 2.73775757752605e-10 2.43489314551223e-09 1.00919492406907 0.872727272727273 5.5 5 5 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.73775757752605e-10 2.43489314551223e-09 1.00919492406907 0.872727272727273 5.5 5 5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 2.73775757752605e-10 2.43489314551223e-09 1.00919492406907 0.872727272727273 5.5 5 5 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 5.90137570665793e-09 4.17793911968867e-08 1.0087475858935 0.872340425531915 5.5 5 5 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 5.90137570665793e-09 4.17793911968867e-08 1.0087475858935 0.872340425531915 5.5 5 5 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 2.42101693761518e-11 2.57097544942269e-10 1.00716025688344 0.870967741935484 5.5 5 5 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.42101693761518e-11 2.57097544942269e-10 1.00716025688344 0.870967741935484 5.5 5 5 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 2.85703351999031e-06 1.30306368555968e-05 1.00716025688344 0.870967741935484 5.5 5 5 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 2.85703351999031e-06 1.30306368555968e-05 1.00716025688344 0.870967741935484 5.5 5 5 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 5.17389550168394e-10 4.35648124195044e-09 1.00646947481425 0.87037037037037 5.5 5 5 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.07119795626552e-17 7.36828672941458e-16 1.00604118993135 0.87 5.5 5 5 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 2.15065775508262e-12 2.66120520476745e-11 1.00553842072099 0.869565217391304 5.5 5 5 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 6.51926722288477e-05 0.000224572758899579 1.00553842072099 0.869565217391304 5.5 5 5 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 9.75224515068425e-10 7.92996848538496e-09 1.00364117841774 0.867924528301887 5.5 5 5 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 8.59016178913239e-11 8.1492001506236e-10 1.00218662598525 0.866666666666667 5.5 5 5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 5.39587131882365e-06 2.24512423587312e-05 1.00218662598525 0.866666666666667 5.5 5 5 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0015631252552088 0.00402229156991343 1.00218662598525 0.866666666666667 5.5 5 5 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0015631252552088 0.00402229156991343 1.00218662598525 0.866666666666667 5.5 5 5 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0015631252552088 0.00402229156991343 1.00218662598525 0.866666666666667 5.5 5 5 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0015631252552088 0.00402229156991343 1.00218662598525 0.866666666666667 5.5 5 5 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.5753549839248e-21 1.46589205685e-19 1.00157960804099 0.866141732283465 5.5 5 5 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.8332082227917e-09 1.38758260693223e-08 1.0007041013906 0.865384615384615 5.5 5 5 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000123088731086851 0.000401732257652726 0.998682476943347 0.863636363636364 5.5 5 5 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000123088731086851 0.000401732257652726 0.998682476943347 0.863636363636364 5.5 5 5 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.41820194724592e-26 4.05794808996365e-24 0.997368421052631 0.8625 5.5 5 5 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.01439360398505e-05 4.0547249957043e-05 0.996869986059602 0.862068965517241 5.5 5 5 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.40930032530469e-33 1.8231221480987e-31 0.996680106062257 0.861904761904762 5.5 5 5 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.85565968188683e-21 1.5629245105096e-19 0.996256527606642 0.861538461538462 5.5 5 5 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.10963270950927e-13 3.49070621585081e-12 0.995355753169385 0.860759493670886 5.5 5 5 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 5.33003229833553e-21 2.80912442982647e-19 0.995015344225072 0.86046511627907 5.5 5 5 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 6.42239779516417e-09 4.52429310025674e-08 0.994477498093059 0.86 5.5 5 5 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.04940955404233e-09 8.43677850509739e-09 0.991173586139261 0.857142857142857 5.5 5 5 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 1.89762273892621e-05 7.23945618630564e-05 0.991173586139261 0.857142857142857 5.5 5 5 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 1.89762273892621e-05 7.23945618630564e-05 0.991173586139261 0.857142857142857 5.5 5 5 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00294967201451588 0.00715056776261687 0.991173586139261 0.857142857142857 5.5 5 5 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00294967201451588 0.00715056776261687 0.991173586139261 0.857142857142857 5.5 5 5 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00294967201451588 0.00715056776261687 0.991173586139261 0.857142857142857 5.5 5 5 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.041933155571301 0.0736677535530386 0.991173586139261 0.857142857142857 5.5 5 5 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.22261690268449e-08 1.32334052406696e-07 0.987732011187389 0.854166666666667 5.5 5 5 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.97860358262186e-06 1.34331522524295e-05 0.986314892089559 0.852941176470588 5.5 5 5 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 2.97860358262186e-06 1.34331522524295e-05 0.986314892089559 0.852941176470588 5.5 5 5 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 3.60777556324354e-09 2.64632197242039e-08 0.985055230669266 0.851851851851852 5.5 5 5 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 3.53115045777524e-05 0.000128184364831994 0.985055230669266 0.851851851851852 5.5 5 5 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.21829044937343e-11 4.98364248956939e-10 0.983776768332252 0.850746268656716 5.5 5 5 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 9.20984391329933e-17 3.19648972893291e-15 0.983454165686463 0.850467289719626 5.5 5 5 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000430441358369555 0.00129770773932177 0.982913806254767 0.85 5.5 5 5 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000430441358369555 0.00129770773932177 0.982913806254767 0.85 5.5 5 5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000430441358369555 0.00129770773932177 0.982913806254767 0.85 5.5 5 5 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.000430441358369555 0.00129770773932177 0.982913806254767 0.85 5.5 5 5 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000430441358369555 0.00129770773932177 0.982913806254767 0.85 5.5 5 5 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000430441358369555 0.00129770773932177 0.982913806254767 0.85 5.5 5 5 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000430441358369555 0.00129770773932177 0.982913806254767 0.85 5.5 5 5 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000430441358369555 0.00129770773932177 0.982913806254767 0.85 5.5 5 5 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 5.51222531504717e-06 2.28020250677678e-05 0.981161731733814 0.848484848484849 5.5 5 5 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 5.51222531504717e-06 2.28020250677678e-05 0.981161731733814 0.848484848484849 5.5 5 5 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 6.7442045652404e-33 7.38231007410545e-31 0.980061774635458 0.847533632286996 5.5 5 5 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 1.08293437928896e-09 8.65739113330445e-09 0.979973884600964 0.847457627118644 5.5 5 5 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.57700724025435e-11 1.70856004053512e-10 0.97970166963302 0.847222222222222 5.5 5 5 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.57700724025435e-11 1.70856004053512e-10 0.97970166963302 0.847222222222222 5.5 5 5 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.76769563034045e-10 1.64407247187874e-09 0.978466232470809 0.846153846153846 5.5 5 5 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.22533787883523e-08 7.5482935133443e-08 0.978466232470809 0.846153846153846 5.5 5 5 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.22533787883523e-08 7.5482935133443e-08 0.978466232470809 0.846153846153846 5.5 5 5 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 6.53359959131594e-05 0.000224572758899579 0.978466232470809 0.846153846153846 5.5 5 5 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 6.53359959131594e-05 0.000224572758899579 0.978466232470809 0.846153846153846 5.5 5 5 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 6.53359959131594e-05 0.000224572758899579 0.978466232470809 0.846153846153846 5.5 5 5 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00551318400165428 0.0126332702646603 0.978466232470809 0.846153846153846 5.5 5 5 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00551318400165428 0.0126332702646603 0.978466232470809 0.846153846153846 5.5 5 5 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00551318400165428 0.0126332702646603 0.978466232470809 0.846153846153846 5.5 5 5 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.26781970200555e-13 6.55070629562954e-12 0.977407286331771 0.845238095238095 5.5 5 5 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.26781970200555e-13 6.55070629562954e-12 0.977407286331771 0.845238095238095 5.5 5 5 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.89426716326519e-11 3.00623516301194e-10 0.977213394785187 0.845070422535211 5.5 5 5 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.73871838778217e-16 5.75394480421868e-15 0.976018026718172 0.844036697247706 5.5 5 5 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 3.24061120999832e-10 2.81182301940708e-09 0.975686498855835 0.84375 5.5 5 5 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 3.24061120999832e-10 2.81182301940708e-09 0.975686498855835 0.84375 5.5 5 5 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.24061120999832e-10 2.81182301940708e-09 0.975686498855835 0.84375 5.5 5 5 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.28082208303767e-26 1.80311656897923e-24 0.973119422457308 0.841530054644809 5.5 5 5 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.42755681080098e-12 2.07287075690796e-11 0.973042362002567 0.841463414634146 5.5 5 5 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 2.55464121268319e-07 1.33159503503596e-06 0.972401359129048 0.840909090909091 5.5 5 5 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.55464121268319e-07 1.33159503503596e-06 0.972401359129048 0.840909090909091 5.5 5 5 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.55464121268319e-07 1.33159503503596e-06 0.972401359129048 0.840909090909091 5.5 5 5 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.5848905506018e-11 1.70856004053512e-10 0.971350114416476 0.84 5.5 5 5 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.5848905506018e-11 1.70856004053512e-10 0.971350114416476 0.84 5.5 5 5 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.5848905506018e-11 1.70856004053512e-10 0.971350114416476 0.84 5.5 5 5 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.5848905506018e-11 1.70856004053512e-10 0.971350114416476 0.84 5.5 5 5 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.5848905506018e-11 1.70856004053512e-10 0.971350114416476 0.84 5.5 5 5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 4.10740844823732e-08 2.37595212269988e-07 0.971350114416476 0.84 5.5 5 5 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000120150468282661 0.000395099932917894 0.971350114416476 0.84 5.5 5 5 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000120150468282661 0.000395099932917894 0.971350114416476 0.84 5.5 5 5 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.28120650381973e-13 6.55070629562954e-12 0.970286786431346 0.839080459770115 5.5 5 5 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.28120650381973e-13 6.55070629562954e-12 0.970286786431346 0.839080459770115 5.5 5 5 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.98300539145749e-36 6.06402381720572e-34 0.969571084902893 0.838461538461538 5.5 5 5 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 4.65928448746851e-07 2.39356022587281e-06 0.968123037624395 0.837209302325581 5.5 5 5 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.77327106136287e-16 1.82563660451541e-14 0.967145135566188 0.836363636363636 5.5 5 5 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.000219491791541134 0.000697180400363914 0.963640986524282 0.833333333333333 5.5 5 5 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000219491791541134 0.000697180400363914 0.963640986524282 0.833333333333333 5.5 5 5 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000219491791541134 0.000697180400363914 0.963640986524282 0.833333333333333 5.5 5 5 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000219491791541134 0.000697180400363914 0.963640986524282 0.833333333333333 5.5 5 5 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.010191800956604 0.0219077534157817 0.963640986524282 0.833333333333333 5.5 5 5 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.010191800956604 0.0219077534157817 0.963640986524282 0.833333333333333 5.5 5 5 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.010191800956604 0.0219077534157817 0.963640986524282 0.833333333333333 5.5 5 5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.010191800956604 0.0219077534157817 0.963640986524282 0.833333333333333 5.5 5 5 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.010191800956604 0.0219077534157817 0.963640986524282 0.833333333333333 5.5 5 5 ACTIVATION OF TRKA RECEPTORS%REACTOME%REACT_217410.1 ACTIVATION OF TRKA RECEPTORS 0.0789373839811013 0.127355892749555 0.963640986524282 0.833333333333333 5.5 5 5 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0789373839811013 0.127355892749555 0.963640986524282 0.833333333333333 5.5 5 5 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0789373839811013 0.127355892749555 0.963640986524282 0.833333333333333 5.5 5 5 SYNTHESIS OF PG%REACTOME%REACT_199032.2 SYNTHESIS OF PG 0.0789373839811013 0.127355892749555 0.963640986524282 0.833333333333333 5.5 5 5 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0789373839811013 0.127355892749555 0.963640986524282 0.833333333333333 5.5 5 5 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0789373839811013 0.127355892749555 0.963640986524282 0.833333333333333 5.5 5 5 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0789373839811013 0.127355892749555 0.963640986524282 0.833333333333333 5.5 5 5 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 48%5604869 NONHOMOLOGOUS END-JOINING (NHEJ) 0.0789373839811013 0.127355892749555 0.963640986524282 0.833333333333333 5.5 5 5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 9.48056677831934e-11 8.93433544738306e-10 0.963640986524282 0.833333333333333 5.5 5 5 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00146070700641137 0.00382947766879533 0.963640986524282 0.833333333333333 5.5 5 5 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00146070700641137 0.00382947766879533 0.963640986524282 0.833333333333333 5.5 5 5 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00146070700641137 0.00382947766879533 0.963640986524282 0.833333333333333 5.5 5 5 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.0471287691955e-09 8.43677850509739e-09 0.960675937334976 0.830769230769231 5.5 5 5 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 1.53031318660311e-06 7.33210661460007e-06 0.958940298785139 0.829268292682927 5.5 5 5 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 6.1371225866438e-05 0.000213003059531564 0.956995186617218 0.827586206896552 5.5 5 5 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 7.41239370046513e-19 3.01366749593197e-17 0.956708317556481 0.827338129496403 5.5 5 5 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.59923986140854e-35 2.84464790348044e-33 0.956555391035133 0.827205882352941 5.5 5 5 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000398095010662361 0.00123149826124465 0.95526149968494 0.826086956521739 5.5 5 5 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 5.00933980976078e-29 4.75219369952639e-27 0.954134214459917 0.825112107623318 5.5 5 5 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 2.7546488408578e-06 1.26447267759376e-05 0.954004576659039 0.825 5.5 5 5 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.67790404164295e-23 1.8145987863133e-21 0.953841247678272 0.824858757062147 5.5 5 5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00265519501992483 0.00657103045800528 0.952304033741643 0.823529411764706 5.5 5 5 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00265519501992483 0.00657103045800528 0.952304033741643 0.823529411764706 5.5 5 5 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00265519501992483 0.00657103045800528 0.952304033741643 0.823529411764706 5.5 5 5 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.87827741213198e-22 1.78077772063644e-20 0.952304033741643 0.823529411764706 5.5 5 5 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.27880954944309e-07 7.02604628902518e-07 0.952304033741643 0.823529411764706 5.5 5 5 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.78453954143231e-11 4.66328751195766e-10 0.951442999353088 0.822784810126582 5.5 5 5 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.78453954143231e-11 4.66328751195766e-10 0.951442999353088 0.822784810126582 5.5 5 5 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 5.13930462215955e-22 3.04717936555543e-20 0.951096547646451 0.822485207100592 5.5 5 5 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.90708256066163e-10 2.56942762970279e-09 0.950440425065045 0.821917808219178 5.5 5 5 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.02443348782197e-13 3.38913982725961e-12 0.948222730739893 0.82 5.5 5 5 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.5062208562319e-11 2.64174242845778e-10 0.947386801209414 0.819277108433735 5.5 5 5 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.000716398066085512 0.00207747566042119 0.946120241314749 0.818181818181818 5.5 5 5 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000716398066085512 0.00207747566042119 0.946120241314749 0.818181818181818 5.5 5 5 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.000716398066085512 0.00207747566042119 0.946120241314749 0.818181818181818 5.5 5 5 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0186009922780362 0.0377592182762418 0.946120241314749 0.818181818181818 5.5 5 5 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0186009922780362 0.0377592182762418 0.946120241314749 0.818181818181818 5.5 5 5 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0186009922780362 0.0377592182762418 0.946120241314749 0.818181818181818 5.5 5 5 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.0186009922780362 0.0377592182762418 0.946120241314749 0.818181818181818 5.5 5 5 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0186009922780362 0.0377592182762418 0.946120241314749 0.818181818181818 5.5 5 5 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0186009922780362 0.0377592182762418 0.946120241314749 0.818181818181818 5.5 5 5 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0186009922780362 0.0377592182762418 0.946120241314749 0.818181818181818 5.5 5 5 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.76385628983753e-14 3.86148846221355e-13 0.946120241314749 0.818181818181818 5.5 5 5 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 6.37868139425474e-13 9.55459328844684e-12 0.943974843942154 0.816326530612245 5.5 5 5 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.62040927510484e-20 7.43820128540063e-19 0.943540499688806 0.815950920245399 5.5 5 5 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.17413952503749e-07 6.50116943240601e-07 0.942226742379298 0.814814814814815 5.5 5 5 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 5.61836207840843e-51 1.9987323093938e-48 0.941925133306833 0.814553990610329 5.5 5 5 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 2.51016228048865e-06 1.158644253489e-05 0.941230731023717 0.813953488372093 5.5 5 5 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 2.51016228048865e-06 1.158644253489e-05 0.941230731023717 0.813953488372093 5.5 5 5 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 7.20303907648858e-07 3.5344567606356e-06 0.939549961861175 0.8125 5.5 5 5 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 5.51994048908139e-05 0.000195394908357284 0.939549961861175 0.8125 5.5 5 5 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00477709721785993 0.0111257108690911 0.939549961861175 0.8125 5.5 5 5 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00477709721785993 0.0111257108690911 0.939549961861175 0.8125 5.5 5 5 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00477709721785993 0.0111257108690911 0.939549961861175 0.8125 5.5 5 5 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.46108547020773e-35 8.6345829156729e-33 0.939303296079641 0.812286689419795 5.5 5 5 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.58370863591272e-31 2.62615527778843e-29 0.939273053531714 0.812260536398467 5.5 5 5 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 4.07713082710416e-11 4.02899803261751e-10 0.938699690402477 0.811764705882353 5.5 5 5 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 4.07713082710416e-11 4.02899803261751e-10 0.938699690402477 0.811764705882353 5.5 5 5 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 4.07713082710416e-11 4.02899803261751e-10 0.938699690402477 0.811764705882353 5.5 5 5 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 2.49930356661283e-15 7.25818158222462e-14 0.938365157369546 0.811475409836066 5.5 5 5 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 6.00388294749288e-08 3.403794993738e-07 0.937057786896026 0.810344827586207 5.5 5 5 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 6.00388294749288e-08 3.403794993738e-07 0.937057786896026 0.810344827586207 5.5 5 5 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 2.45215046070079e-10 2.26585071790729e-09 0.936805414747656 0.810126582278481 5.5 5 5 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.0303297916771e-12 1.52724926412136e-11 0.936659038901602 0.81 5.5 5 5 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 5.75145017698683e-61 2.72810453395075e-58 0.936527133671507 0.809885931558935 5.5 5 5 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0012782237200039 0.00341259353389409 0.936108386909302 0.80952380952381 5.5 5 5 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0012782237200039 0.00341259353389409 0.936108386909302 0.80952380952381 5.5 5 5 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.47552955987758e-09 1.12885944285258e-08 0.934599751313961 0.808219178082192 5.5 5 5 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.25045792242735e-20 6.13586766763491e-19 0.934507654373548 0.808139534883721 5.5 5 5 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000350371252234564 0.00109337344721444 0.933990494631227 0.807692307692308 5.5 5 5 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000350371252234564 0.00109337344721444 0.933990494631227 0.807692307692308 5.5 5 5 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.98051312135957e-15 1.0489389206842e-13 0.932555793410595 0.806451612903226 5.5 5 5 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.98051312135957e-15 1.0489389206842e-13 0.932555793410595 0.806451612903226 5.5 5 5 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.98051312135957e-15 1.0489389206842e-13 0.932555793410595 0.806451612903226 5.5 5 5 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.0801294607361e-11 1.24961318912803e-10 0.932555793410595 0.806451612903226 5.5 5 5 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 9.7577725362602e-05 0.000327410652721966 0.932555793410595 0.806451612903226 5.5 5 5 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 2.74822154689766e-05 0.000102913664769352 0.931519620306806 0.805555555555556 5.5 5 5 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.91849203766731e-25 1.36500708480029e-23 0.93035157062617 0.804545454545455 5.5 5 5 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.23091982750007e-06 1.04427595872783e-05 0.930123039166915 0.804347826086957 5.5 5 5 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.23091982750007e-06 1.04427595872783e-05 0.930123039166915 0.804347826086957 5.5 5 5 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 2.23091982750007e-06 1.04427595872783e-05 0.930123039166915 0.804347826086957 5.5 5 5 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 6.40906737915945e-07 3.18884716102934e-06 0.929630128176366 0.803921568627451 5.5 5 5 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.84578001057872e-10 3.29671382834549e-09 0.927950579615975 0.802469135802469 5.5 5 5 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.84578001057872e-10 3.29671382834549e-09 0.927950579615975 0.802469135802469 5.5 5 5 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 3.89813696841956e-06 1.67584559095499e-05 0.92509534706331 0.8 5.5 5 5 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00849585905174423 0.0188018778081369 0.92509534706331 0.8 5.5 5 5 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00849585905174423 0.0188018778081369 0.92509534706331 0.8 5.5 5 5 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.11878384555366e-06 5.45215552131116e-06 0.92509534706331 0.8 5.5 5 5 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.36544724649761e-05 5.32337378566055e-05 0.92509534706331 0.8 5.5 5 5 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.000616857084575028 0.00180243866807036 0.92509534706331 0.8 5.5 5 5 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00225935540703656 0.00568032286963431 0.92509534706331 0.8 5.5 5 5 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0334400810338096 0.0604640855287306 0.92509534706331 0.8 5.5 5 5 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.40227588771759e-20 6.65146196074046e-19 0.922567764147837 0.797814207650273 5.5 5 5 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.16105859447005e-09 9.23009150799374e-09 0.922167830142224 0.79746835443038 5.5 5 5 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.815159784484e-15 8.01194474664146e-14 0.921617545006681 0.796992481203007 5.5 5 5 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.46637758250503e-40 5.8494254998411e-38 0.921385071607174 0.796791443850267 5.5 5 5 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.27449633321274e-12 1.86969925996055e-11 0.920812498234314 0.796296296296296 5.5 5 5 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 4.86410173831926e-15 1.25847577702333e-13 0.919839123500451 0.795454545454545 5.5 5 5 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 4.75051747643635e-27 3.97646256998172e-25 0.919522483526784 0.795180722891566 5.5 5 5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 8.38368705123017e-05 0.000284725218947507 0.918293175393727 0.794117647058823 5.5 5 5 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 8.38368705123017e-05 0.000284725218947507 0.918293175393727 0.794117647058823 5.5 5 5 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00107678724332303 0.00293537978400128 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.18599920788409e-08 7.36976800357665e-08 0.915458937198068 0.791666666666667 5.5 5 5 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.06949344202239e-08 2.36362823183586e-07 0.914739802133497 0.791044776119403 5.5 5 5 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 4.06949344202239e-08 2.36362823183586e-07 0.914739802133497 0.791044776119403 5.5 5 5 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 4.06949344202239e-08 2.36362823183586e-07 0.914739802133497 0.791044776119403 5.5 5 5 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.17189233390364e-05 4.59394708304375e-05 0.914338424423039 0.790697674418605 5.5 5 5 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 4.10762370239615e-05 0.000148354023566236 0.912923039865109 0.789473684210526 5.5 5 5 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.66731078250388e-06 7.96168873658731e-06 0.911752625711436 0.788461538461538 5.5 5 5 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 8.7445464877969e-10 7.15143083456034e-09 0.911491003724144 0.788235294117647 5.5 5 5 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.000144981911292713 0.00047102570723637 0.911078750895685 0.787878787878788 5.5 5 5 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.01934306370832e-08 7.00736801766635e-08 0.909677091278922 0.786666666666667 5.5 5 5 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 3.48727228576088e-08 2.05057374489162e-07 0.908575787294323 0.785714285714286 5.5 5 5 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.00051640701098415 0.00152142272594295 0.908575787294323 0.785714285714286 5.5 5 5 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00051640701098415 0.00152142272594295 0.908575787294323 0.785714285714286 5.5 5 5 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00051640701098415 0.00152142272594295 0.908575787294323 0.785714285714286 5.5 5 5 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0149127279544951 0.0309792874149584 0.908575787294323 0.785714285714286 5.5 5 5 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0149127279544951 0.0309792874149584 0.908575787294323 0.785714285714286 5.5 5 5 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0149127279544951 0.0309792874149584 0.908575787294323 0.785714285714286 5.5 5 5 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0149127279544951 0.0309792874149584 0.908575787294323 0.785714285714286 5.5 5 5 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0149127279544951 0.0309792874149584 0.908575787294323 0.785714285714286 5.5 5 5 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0149127279544951 0.0309792874149584 0.908575787294323 0.785714285714286 5.5 5 5 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.20401692059726e-13 6.55070629562954e-12 0.907893160857588 0.785123966942149 5.5 5 5 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.20401692059726e-13 6.55070629562954e-12 0.907893160857588 0.785123966942149 5.5 5 5 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.21811576302713e-16 4.12709221616096e-15 0.907530245536792 0.784810126582278 5.5 5 5 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 7.05880917401454e-05 0.000241458784966892 0.906343414352568 0.783783783783784 5.5 5 5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 7.05880917401454e-05 0.000241458784966892 0.906343414352568 0.783783783783784 5.5 5 5 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 4.82114758374975e-12 5.81397712853889e-11 0.906343414352568 0.783783783783784 5.5 5 5 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00186228906560886 0.00474917086086274 0.904984578648891 0.782608695652174 5.5 5 5 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00186228906560886 0.00474917086086274 0.904984578648891 0.782608695652174 5.5 5 5 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 4.10959064796861e-12 5.04133404487873e-11 0.902779450533274 0.780701754385965 5.5 5 5 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 3.44524779772173e-05 0.000125385872536011 0.902532045915425 0.780487804878049 5.5 5 5 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 3.44524779772173e-05 0.000125385872536011 0.902532045915425 0.780487804878049 5.5 5 5 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 3.44524779772173e-05 0.000125385872536011 0.902532045915425 0.780487804878049 5.5 5 5 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 3.44524779772173e-05 0.000125385872536011 0.902532045915425 0.780487804878049 5.5 5 5 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.00227291657129e-16 9.70962354609304e-15 0.901822508143479 0.779874213836478 5.5 5 5 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 6.98018555611244e-07 3.44889029387084e-06 0.901575973832887 0.779661016949153 5.5 5 5 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 6.98018555611244e-07 3.44889029387084e-06 0.901575973832887 0.779661016949153 5.5 5 5 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.28507372624291e-14 4.92675744309645e-13 0.900316007409829 0.778571428571429 5.5 5 5 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000885617482794212 0.00248077495672473 0.89939825408933 0.777777777777778 5.5 5 5 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.000885617482794212 0.00248077495672473 0.89939825408933 0.777777777777778 5.5 5 5 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000885617482794212 0.00248077495672473 0.89939825408933 0.777777777777778 5.5 5 5 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000120501314747973 0.000395099932917894 0.89939825408933 0.777777777777778 5.5 5 5 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000120501314747973 0.000395099932917894 0.89939825408933 0.777777777777778 5.5 5 5 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00683590306722191 0.0152947956991459 0.89939825408933 0.777777777777778 5.5 5 5 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00683590306722191 0.0152947956991459 0.89939825408933 0.777777777777778 5.5 5 5 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00683590306722191 0.0152947956991459 0.89939825408933 0.777777777777778 5.5 5 5 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00683590306722191 0.0152947956991459 0.89939825408933 0.777777777777778 5.5 5 5 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00683590306722191 0.0152947956991459 0.89939825408933 0.777777777777778 5.5 5 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.059042770054518 0.0984969071366695 0.89939825408933 0.777777777777778 5.5 5 5 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 8.57251082559893e-16 2.59546444783559e-14 0.898579875332196 0.777070063694268 5.5 5 5 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.85807625100679e-14 7.62505903497593e-13 0.898473898226956 0.776978417266187 5.5 5 5 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.8821533619594e-15 8.04177300797692e-14 0.897707655867357 0.776315789473684 5.5 5 5 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 5.85382135500523e-05 0.000203942114825221 0.896186117467582 0.775 5.5 5 5 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00042414662923104 0.00129770773932177 0.895253561674171 0.774193548387097 5.5 5 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.05856315100031e-09 2.25509604345774e-08 0.893558005686152 0.772727272727273 5.5 5 5 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0031884309433264 0.00769006310568384 0.893558005686152 0.772727272727273 5.5 5 5 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0031884309433264 0.00769006310568384 0.893558005686152 0.772727272727273 5.5 5 5 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0031884309433264 0.00769006310568384 0.893558005686152 0.772727272727273 5.5 5 5 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 6.39994670935086e-20 2.84597630231446e-18 0.892056227525335 0.771428571428571 5.5 5 5 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 9.166959772085e-14 1.65121313362999e-12 0.892056227525335 0.771428571428571 5.5 5 5 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 1.39323594462216e-05 5.41687089944628e-05 0.891367912534961 0.770833333333333 5.5 5 5 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.12894192110275e-09 3.66758007725086e-08 0.890537187546578 0.770114942528736 5.5 5 5 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00150514319237656 0.00391557360649331 0.889514756791645 0.769230769230769 5.5 5 5 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0257871908064364 0.0481563943799987 0.889514756791645 0.769230769230769 5.5 5 5 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0257871908064364 0.0481563943799987 0.889514756791645 0.769230769230769 5.5 5 5 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0257871908064364 0.0481563943799987 0.889514756791645 0.769230769230769 5.5 5 5 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0257871908064364 0.0481563943799987 0.889514756791645 0.769230769230769 5.5 5 5 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0257871908064364 0.0481563943799987 0.889514756791645 0.769230769230769 5.5 5 5 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0257871908064364 0.0481563943799987 0.889514756791645 0.769230769230769 5.5 5 5 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0257871908064364 0.0481563943799987 0.889514756791645 0.769230769230769 5.5 5 5 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0257871908064364 0.0481563943799987 0.889514756791645 0.769230769230769 5.5 5 5 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.26530819740201e-09 9.83898122897844e-09 0.888578425468706 0.768421052631579 5.5 5 5 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.26530819740201e-09 9.83898122897844e-09 0.888578425468706 0.768421052631579 5.5 5 5 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.26530819740201e-09 9.83898122897844e-09 0.888578425468706 0.768421052631579 5.5 5 5 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 2.38746890459873e-07 1.26296217518364e-06 0.888225604970207 0.768115942028985 5.5 5 5 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.38746890459873e-07 1.26296217518364e-06 0.888225604970207 0.768115942028985 5.5 5 5 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 6.28805392517046e-10 5.23269048860677e-09 0.887717757282975 0.767676767676768 5.5 5 5 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 8.57275114537292e-09 5.92185673779887e-08 0.887446117822362 0.767441860465116 5.5 5 5 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000716823998079271 0.00207747566042119 0.886549707602339 0.766666666666667 5.5 5 5 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.011673279361149 0.0247557027286363 0.884282317045812 0.764705882352941 5.5 5 5 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.011673279361149 0.0247557027286363 0.884282317045812 0.764705882352941 5.5 5 5 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.011673279361149 0.0247557027286363 0.884282317045812 0.764705882352941 5.5 5 5 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.74377953509610e-12 5.76957117815535e-11 0.883211108908869 0.763779527559055 5.5 5 5 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 9.70056765868104e-08 5.43460936153666e-07 0.882492271869605 0.763157894736842 5.5 5 5 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 4.28529603810031e-10 3.62974777512901e-09 0.881043187679343 0.761904761904762 5.5 5 5 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0053989768055411 0.0124316245862216 0.881043187679343 0.761904761904762 5.5 5 5 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0053989768055411 0.0124316245862216 0.881043187679343 0.761904761904762 5.5 5 5 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0053989768055411 0.0124316245862216 0.881043187679343 0.761904761904762 5.5 5 5 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 3.89727813414752e-05 0.000141115185366207 0.879846118130866 0.760869565217391 5.5 5 5 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00253323274602504 0.00630208076502384 0.878840579710145 0.76 5.5 5 5 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00253323274602504 0.00630208076502384 0.878840579710145 0.76 5.5 5 5 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00253323274602504 0.00630208076502384 0.878840579710145 0.76 5.5 5 5 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00120093211395888 0.00324274458854552 0.87724558773245 0.758620689655172 5.5 5 5 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00120093211395888 0.00324274458854552 0.87724558773245 0.758620689655172 5.5 5 5 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 6.67592145838846e-73 9.49983623528678e-70 0.876433657427062 0.757918552036199 5.5 5 5 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.000573763115567174 0.00168343281124142 0.87603726047662 0.757575757575758 5.5 5 5 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 3.476057069258e-18 1.30169189725109e-16 0.875536667756347 0.757142857142857 5.5 5 5 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.79374303837478e-10 4.84970373153372e-09 0.875382279347292 0.757009345794392 5.5 5 5 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.52288222039608e-11 3.63265318813306e-10 0.874327919480568 0.75609756097561 5.5 5 5 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000133203993825841 0.000433751220169728 0.874327919480568 0.75609756097561 5.5 5 5 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.53309380792661e-05 5.92824045836838e-05 0.872731459493689 0.754716981132076 5.5 5 5 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.54634448806618e-09 1.91716836323713e-08 0.867276887871854 0.75 5.5 5 5 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 7.14745759580227e-07 3.51931908609918e-06 0.867276887871854 0.75 5.5 5 5 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 5.16853948133015e-05 0.000184331621101073 0.867276887871854 0.75 5.5 5 5 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00094979990721005 0.00265533451465599 0.867276887871854 0.75 5.5 5 5 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00421879453246635 0.00998892615590618 0.867276887871854 0.75 5.5 5 5 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00421879453246635 0.00998892615590618 0.867276887871854 0.75 5.5 5 5 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00421879453246635 0.00998892615590618 0.867276887871854 0.75 5.5 5 5 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0196521445533971 0.0396104839936035 0.867276887871854 0.75 5.5 5 5 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0196521445533971 0.0396104839936035 0.867276887871854 0.75 5.5 5 5 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0196521445533971 0.0396104839936035 0.867276887871854 0.75 5.5 5 5 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0196521445533971 0.0396104839936035 0.867276887871854 0.75 5.5 5 5 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.043828566242333 0.0767134683429764 0.867276887871854 0.75 5.5 5 5 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.043828566242333 0.0767134683429764 0.867276887871854 0.75 5.5 5 5 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605624 SODIUM CALCIUM EXCHANGERS 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 RELAXIN RECEPTORS%REACTOME%REACT_198713.2 RELAXIN RECEPTORS 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.101987973235105 0.156220544578638 0.867276887871854 0.75 5.5 5 5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.4273637038592e-13 2.4471548802309e-12 0.867276887871853 0.75 5.5 5 5 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00903200437916215 0.0198955762098262 0.867276887871853 0.75 5.5 5 5 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00903200437916215 0.0198955762098262 0.867276887871853 0.75 5.5 5 5 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.76408827013724e-15 5.2297866841777e-14 0.86573093976513 0.748663101604278 5.5 5 5 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 8.36670625444089e-09 5.80771853661922e-08 0.864356763670265 0.747474747474748 5.5 5 5 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.39726317166061e-07 7.56009693259712e-07 0.863793848161525 0.746987951807229 5.5 5 5 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 9.83461670304325e-06 3.94215762491001e-05 0.862377018448849 0.745762711864407 5.5 5 5 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 7.52061766852148e-15 1.86518969284101e-13 0.860992272742347 0.744565217391304 5.5 5 5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.000746512011842835 0.00214170684042813 0.85901710798736 0.742857142857143 5.5 5 5 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 2.19667136092311e-08 1.31338796075361e-07 0.858335889027814 0.742268041237113 5.5 5 5 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.59444582091913e-12 2.26889640316792e-11 0.857951329937748 0.741935483870968 5.5 5 5 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 7.82844090461628e-06 3.20111247335315e-05 0.857951329937748 0.741935483870968 5.5 5 5 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00155827143351792 0.00402229156991343 0.857951329937748 0.741935483870968 5.5 5 5 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 8.96069564176506e-08 5.03994857637616e-07 0.857532203738462 0.741573033707865 5.5 5 5 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0032752166483261 0.00784618399085528 0.856569765799362 0.740740740740741 5.5 5 5 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0032752166483261 0.00784618399085528 0.856569765799362 0.740740740740741 5.5 5 5 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0032752166483261 0.00784618399085528 0.856569765799362 0.740740740740741 5.5 5 5 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0032752166483261 0.00784618399085528 0.856569765799362 0.740740740740741 5.5 5 5 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.50553064664814e-06 7.24115453069785e-06 0.85539638255854 0.73972602739726 5.5 5 5 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.000282542766275286 0.000889509638074628 0.853510588064364 0.738095238095238 5.5 5 5 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 1.19512784551365e-06 5.78458137471403e-06 0.852061503874102 0.736842105263158 5.5 5 5 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000584081041956422 0.00171017967634565 0.852061503874102 0.736842105263158 5.5 5 5 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.014909382235253 0.0309792874149584 0.852061503874102 0.736842105263158 5.5 5 5 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.014909382235253 0.0309792874149584 0.852061503874102 0.736842105263158 5.5 5 5 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.014909382235253 0.0309792874149584 0.852061503874102 0.736842105263158 5.5 5 5 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.014909382235253 0.0309792874149584 0.852061503874102 0.736842105263158 5.5 5 5 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 5.26526404959547e-05 0.000187311768564359 0.850913173006347 0.735849056603774 5.5 5 5 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00121281817595085 0.00325016998941255 0.850271458697896 0.735294117647059 5.5 5 5 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00121281817595085 0.00325016998941255 0.850271458697896 0.735294117647059 5.5 5 5 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00121281817595085 0.00325016998941255 0.850271458697896 0.735294117647059 5.5 5 5 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00121281817595085 0.00325016998941255 0.850271458697896 0.735294117647059 5.5 5 5 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000107791843188477 0.000356715797342331 0.849577359547938 0.73469387755102 5.5 5 5 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.03255911743706 0.0598599794740781 0.848004068141368 0.733333333333333 5.5 5 5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.03255911743706 0.0598599794740781 0.848004068141368 0.733333333333333 5.5 5 5 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.03255911743706 0.0598599794740781 0.848004068141368 0.733333333333333 5.5 5 5 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.03255911743706 0.0598599794740781 0.848004068141368 0.733333333333333 5.5 5 5 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.03255911743706 0.0598599794740781 0.848004068141368 0.733333333333333 5.5 5 5 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 7.02164858212868e-09 4.92207188786656e-08 0.846627438160619 0.732142857142857 5.5 5 5 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00045545884205565 0.00136165199443954 0.846123793045711 0.731707317073171 5.5 5 5 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.06352008845893e-11 1.24048285727627e-10 0.845039018952062 0.730769230769231 5.5 5 5 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0053237615344995 0.0123182319733216 0.845039018952062 0.730769230769231 5.5 5 5 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0053237615344995 0.0123182319733216 0.845039018952062 0.730769230769231 5.5 5 5 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0053237615344995 0.0123182319733216 0.845039018952062 0.730769230769231 5.5 5 5 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 5.90054393591784e-07 2.94613123537231e-06 0.843469287028312 0.729411764705882 5.5 5 5 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 5.90054393591784e-07 2.94613123537231e-06 0.843469287028312 0.729411764705882 5.5 5 5 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 5.90054393591784e-07 2.94613123537231e-06 0.843469287028312 0.729411764705882 5.5 5 5 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 5.90054393591784e-07 2.94613123537231e-06 0.843469287028312 0.729411764705882 5.5 5 5 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 5.90054393591784e-07 2.94613123537231e-06 0.843469287028312 0.729411764705882 5.5 5 5 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000172769808724077 0.000558753267759911 0.843185863208747 0.729166666666667 5.5 5 5 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.19014149127893e-06 5.78010696959017e-06 0.842293603036039 0.728395061728395 5.5 5 5 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.30850585980854e-07 1.23033851629496e-06 0.842138427353829 0.728260869565217 5.5 5 5 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.64699445861675e-07 2.39356022587281e-06 0.840995770057555 0.727272727272727 5.5 5 5 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0730109843825385 0.119282010076179 0.840995770057555 0.727272727272727 5.5 5 5 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.74124605752877e-09 2.04230007322693e-08 0.839300214069536 0.725806451612903 5.5 5 5 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.79575855070863e-08 1.65077361728564e-07 0.838102435986256 0.724770642201835 5.5 5 5 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 6.09191311128311e-35 8.66879235735587e-33 0.838042835471679 0.724719101123595 5.5 5 5 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00407308045692137 0.00969229680635304 0.837370788290066 0.724137931034483 5.5 5 5 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0242504577253593 0.0458278902299951 0.835155521654377 0.722222222222222 5.5 5 5 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0242504577253593 0.0458278902299951 0.835155521654377 0.722222222222222 5.5 5 5 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0242504577253593 0.0458278902299951 0.835155521654377 0.722222222222222 5.5 5 5 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0242504577253593 0.0458278902299951 0.835155521654377 0.722222222222222 5.5 5 5 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00855309626902975 0.0188991552652629 0.832585812356979 0.72 5.5 5 5 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.54450655502505e-11 2.66237707926518e-10 0.832021729828282 0.719512195121951 5.5 5 5 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.06385457818245e-08 7.27819742670013e-08 0.831438999943265 0.71900826446281 5.5 5 5 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 6.20033516778086e-13 9.38625206782146e-12 0.831140350877193 0.71875 5.5 5 5 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00115553011760956 0.00313203687115888 0.830213773005535 0.717948717948718 5.5 5 5 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00115553011760956 0.00313203687115888 0.830213773005535 0.717948717948718 5.5 5 5 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00115553011760956 0.00313203687115888 0.830213773005535 0.717948717948718 5.5 5 5 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000165047705933668 0.000534995183470637 0.829094886519005 0.716981132075472 5.5 5 5 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.29989067500523e-08 7.97303633850189e-08 0.827321042089139 0.715447154471545 5.5 5 5 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.000335214722563076 0.00105068403129352 0.825977988449384 0.714285714285714 5.5 5 5 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000335214722563076 0.00105068403129352 0.825977988449384 0.714285714285714 5.5 5 5 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.00237858358622091 0.00595902190702879 0.825977988449384 0.714285714285714 5.5 5 5 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00237858358622091 0.00595902190702879 0.825977988449384 0.714285714285714 5.5 5 5 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00648013602358033 0.0146136823479474 0.825977988449384 0.714285714285714 5.5 5 5 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0181145733132148 0.0371593801786916 0.825977988449384 0.714285714285714 5.5 5 5 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0529733479362896 0.0896326683868491 0.825977988449384 0.714285714285714 5.5 5 5 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0529733479362896 0.0896326683868491 0.825977988449384 0.714285714285714 5.5 5 5 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0529733479362896 0.0896326683868491 0.825977988449384 0.714285714285714 5.5 5 5 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0529733479362896 0.0896326683868491 0.825977988449384 0.714285714285714 5.5 5 5 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%REACT_225157.1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_216831.1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 THE NLRP3 INFLAMMASOME%REACTOME%REACT_198644.2 THE NLRP3 INFLAMMASOME 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%REACT_202086.1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.171447955005602 0.248949428543848 0.825977988449384 0.714285714285714 5.5 5 5 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.22950369307462e-09 9.7199097513621e-09 0.824822774479525 0.713286713286713 5.5 5 5 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.76985976486372e-46 7.88302089080215e-44 0.824708880144468 0.713188220230474 5.5 5 5 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.61448778131777e-07 1.35781609956759e-06 0.822801150032271 0.711538461538462 5.5 5 5 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000258376543947853 0.000817044048972877 0.822801150032271 0.711538461538462 5.5 5 5 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.13509642106837e-05 4.46199504745938e-05 0.821630735878598 0.710526315789474 5.5 5 5 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00181707202429213 0.00465052786073327 0.821630735878598 0.710526315789474 5.5 5 5 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 3.41901089682443e-06 1.48330869090889e-05 0.820215351320668 0.709302325581395 5.5 5 5 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 2.94240944403381e-09 2.18075449940631e-08 0.820119988531304 0.709219858156028 5.5 5 5 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.89994612747751e-08 1.1407693415192e-07 0.819474224760806 0.708661417322835 5.5 5 5 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 2.18804083143705e-19 9.43509728222704e-18 0.819390433940279 0.708588957055215 5.5 5 5 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0135686404675283 0.0286897108251007 0.819094838545639 0.708333333333333 5.5 5 5 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00138822891714739 0.00369934409943957 0.817919666610854 0.707317073170732 5.5 5 5 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 5.27873234174359e-06 2.20282584231705e-05 0.81626060034998 0.705882352941177 5.5 5 5 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 5.27873234174359e-06 2.20282584231705e-05 0.81626060034998 0.705882352941177 5.5 5 5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 4.54386558033089e-05 0.000162869539567024 0.81626060034998 0.705882352941177 5.5 5 5 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00372795630646091 0.00888589920283732 0.81626060034998 0.705882352941177 5.5 5 5 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00372795630646091 0.00888589920283732 0.81626060034998 0.705882352941177 5.5 5 5 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0388014210147928 0.0692778194530114 0.81626060034998 0.705882352941177 5.5 5 5 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0388014210147928 0.0692778194530114 0.81626060034998 0.705882352941177 5.5 5 5 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0388014210147928 0.0692778194530114 0.81626060034998 0.705882352941177 5.5 5 5 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0388014210147928 0.0692778194530114 0.81626060034998 0.705882352941177 5.5 5 5 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.35830297181066e-05 5.31006903540266e-05 0.815388527059008 0.705128205128205 5.5 5 5 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 5.78254338131365e-08 3.32751800119386e-07 0.815145490240212 0.704918032786885 5.5 5 5 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0101890556391613 0.0219077534157817 0.813741277509394 0.703703703703704 5.5 5 5 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0101890556391613 0.0219077534157817 0.813741277509394 0.703703703703704 5.5 5 5 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 1.04989202386356e-05 4.13849404420457e-05 0.813741277509393 0.703703703703704 5.5 5 5 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 5.38378522923633e-05 0.00019105053319709 0.809458428680397 0.7 5.5 5 5 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00766839951360635 0.0170502070435341 0.809458428680397 0.7 5.5 5 5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00766839951360635 0.0170502070435341 0.809458428680397 0.7 5.5 5 5 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.028623263899465 0.0533127022630087 0.809458428680397 0.7 5.5 5 5 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.118782377769504 0.180584747399577 0.809458428680397 0.7 5.5 5 5 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.118782377769504 0.180584747399577 0.809458428680397 0.7 5.5 5 5 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.118782377769504 0.180584747399577 0.809458428680397 0.7 5.5 5 5 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.118782377769504 0.180584747399577 0.809458428680397 0.7 5.5 5 5 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.118782377769504 0.180584747399577 0.809458428680397 0.7 5.5 5 5 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.118782377769504 0.180584747399577 0.809458428680397 0.7 5.5 5 5 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.118782377769504 0.180584747399577 0.809458428680397 0.7 5.5 5 5 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.49945536823293e-14 7.01369716759923e-13 0.807622922039398 0.698412698412698 5.5 5 5 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.49945536823293e-14 7.01369716759923e-13 0.807622922039398 0.698412698412698 5.5 5 5 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.49945536823293e-14 7.01369716759923e-13 0.807622922039398 0.698412698412698 5.5 5 5 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00163713603767083 0.00419755780469476 0.806769198020329 0.697674418604651 5.5 5 5 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.00578284016047944 0.0130826415713231 0.80595427963849 0.696969696969697 5.5 5 5 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.00578284016047944 0.0130826415713231 0.80595427963849 0.696969696969697 5.5 5 5 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.021231897980028 0.0417372547633915 0.804430736576792 0.695652173913043 5.5 5 5 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.88952250406187e-05 7.23945618630564e-05 0.803817603393425 0.695121951219512 5.5 5 5 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0158190994217228 0.0327664897774549 0.80056328111248 0.692307692307692 5.5 5 5 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0844216609731003 0.134677156462693 0.80056328111248 0.692307692307692 5.5 5 5 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0844216609731003 0.134677156462693 0.80056328111248 0.692307692307692 5.5 5 5 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0844216609731003 0.134677156462693 0.80056328111248 0.692307692307692 5.5 5 5 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0844216609731003 0.134677156462693 0.80056328111248 0.692307692307692 5.5 5 5 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.0844216609731003 0.134677156462693 0.80056328111248 0.692307692307692 5.5 5 5 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0844216609731003 0.134677156462693 0.80056328111248 0.692307692307692 5.5 5 5 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.86257474530726e-05 0.000106914537075387 0.799465114746071 0.691358024691358 5.5 5 5 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.000552494024921456 0.0016243780939323 0.798945981554677 0.690909090909091 5.5 5 5 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00250468404665382 0.00626391106922389 0.798445388834405 0.69047619047619 5.5 5 5 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.00144338200921586 0.00382947766879533 0.795003813882532 0.6875 5.5 5 5 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0609544577811182 0.101566971220762 0.795003813882532 0.6875 5.5 5 5 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.9381754697129e-07 1.04076365788734e-06 0.794452111027652 0.687022900763359 5.5 5 5 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.9381754697129e-07 1.04076365788734e-06 0.794452111027652 0.687022900763359 5.5 5 5 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 5.52409479834873e-14 1.04810491974003e-12 0.793177418510961 0.685920577617328 5.5 5 5 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00502847342262093 0.0116920223535778 0.791199967883094 0.684210526315789 5.5 5 5 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0444894546205897 0.0777745625615469 0.791199967883094 0.684210526315789 5.5 5 5 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 7.28462771826818e-10 5.99192210583562e-09 0.788981057716756 0.682291666666667 5.5 5 5 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 4.01481622046676e-06 1.72080827762777e-05 0.788924770275954 0.682242990654206 5.5 5 5 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 3.0868874114859e-06 1.34331522524295e-05 0.788433534428958 0.681818181818182 5.5 5 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000282493749151438 0.000889509638074628 0.788433534428958 0.681818181818182 5.5 5 5 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.000761339628e-69 1.42354169314532e-66 0.786838682863726 0.680438992898644 5.5 5 5 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0242266718893377 0.0458278902299951 0.786331045003814 0.68 5.5 5 5 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0242266718893377 0.0458278902299951 0.786331045003814 0.68 5.5 5 5 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0242266718893377 0.0458278902299951 0.786331045003814 0.68 5.5 5 5 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0242266718893377 0.0458278902299951 0.786331045003814 0.68 5.5 5 5 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.54959963561885e-28 1.37817517592852e-26 0.784101032891919 0.678071539657854 5.5 5 5 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0134547056215637 0.0284911400289958 0.7833468664649 0.67741935483871 5.5 5 5 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00570132455406674 0.0130224475769454 0.780549199084668 0.675 5.5 5 5 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00570132455406674 0.0130224475769454 0.780549199084668 0.675 5.5 5 5 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00107644746631577 0.00293537978400128 0.777558589126489 0.672413793103448 5.5 5 5 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00107644746631577 0.00293537978400128 0.777558589126489 0.672413793103448 5.5 5 5 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00107644746631577 0.00293537978400128 0.777558589126489 0.672413793103448 5.5 5 5 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.10521032352782e-23 2.65532467744549e-21 0.771587844201229 0.667250437828371 5.5 5 5 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.00158616760086994 0.00407421750187352 0.770912789219425 0.666666666666667 5.5 5 5 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0150517920731028 0.0312225949271506 0.770912789219425 0.666666666666667 5.5 5 5 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0679033475936597 0.112881382740395 0.770912789219425 0.666666666666667 5.5 5 5 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.13137582066295 0.198458378772163 0.770912789219425 0.666666666666667 5.5 5 5 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.13137582066295 0.198458378772163 0.770912789219425 0.666666666666667 5.5 5 5 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.13137582066295 0.198458378772163 0.770912789219425 0.666666666666667 5.5 5 5 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.13137582066295 0.198458378772163 0.770912789219425 0.666666666666667 5.5 5 5 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.18787837959628 0.270324503706276 0.770912789219425 0.666666666666667 5.5 5 5 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.18787837959628 0.270324503706276 0.770912789219425 0.666666666666667 5.5 5 5 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.18787837959628 0.270324503706276 0.770912789219425 0.666666666666667 5.5 5 5 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.18787837959628 0.270324503706276 0.770912789219425 0.666666666666667 5.5 5 5 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.18787837959628 0.270324503706276 0.770912789219425 0.666666666666667 5.5 5 5 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.18787837959628 0.270324503706276 0.770912789219425 0.666666666666667 5.5 5 5 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.18787837959628 0.270324503706276 0.770912789219425 0.666666666666667 5.5 5 5 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0201506461545882 0.040557806899546 0.770912789219425 0.666666666666667 5.5 5 5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.093801808934749 0.148973185395254 0.770912789219425 0.666666666666667 5.5 5 5 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.093801808934749 0.148973185395254 0.770912789219425 0.666666666666667 5.5 5 5 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 3.51533625043519e-07 1.81902672158883e-06 0.76842597377033 0.664516129032258 5.5 5 5 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 5.11470509412886e-19 2.1406545143957e-17 0.763904491135612 0.660606060606061 5.5 5 5 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0166102142209272 0.0343052755244983 0.759899749373434 0.657142857142857 5.5 5 5 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0166102142209272 0.0343052755244983 0.759899749373434 0.657142857142857 5.5 5 5 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00336479452137122 0.00804723126707772 0.756896193051799 0.654545454545455 5.5 5 5 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0401076421059438 0.0714307568420001 0.756087543272898 0.653846153846154 5.5 5 5 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0401076421059438 0.0714307568420001 0.756087543272898 0.653846153846154 5.5 5 5 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00585930159266163 0.0132345812164405 0.755179875153723 0.653061224489796 5.5 5 5 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0542906360256164 0.0917524644470927 0.754153815540742 0.652173913043478 5.5 5 5 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00212600341406867 0.00538216384473523 0.752557722809439 0.650793650793651 5.5 5 5 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0739552373883927 0.120547884082111 0.75163996948894 0.65 5.5 5 5 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.92482499050132e-33 3.46835496790282e-31 0.751234835140251 0.64964964964965 5.5 5 5 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0181227054420323 0.0371593801786916 0.750077308429711 0.648648648648649 5.5 5 5 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.101568358519382 0.156220544578638 0.748238883654148 0.647058823529412 5.5 5 5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00842784287313258 0.0187095482191383 0.746821764556318 0.645833333333333 5.5 5 5 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0323250834873601 0.0598161167783009 0.746044634728476 0.645161290322581 5.5 5 5 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0111436516357963 0.0238816510206899 0.745215696245444 0.644444444444444 5.5 5 5 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00191204152528309 0.00486732574325195 0.743380189604446 0.642857142857143 5.5 5 5 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.141028624439359 0.211915240313842 0.743380189604446 0.642857142857143 5.5 5 5 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.141028624439359 0.211915240313842 0.743380189604446 0.642857142857143 5.5 5 5 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.141028624439359 0.211915240313842 0.743380189604446 0.642857142857143 5.5 5 5 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.141028624439359 0.211915240313842 0.743380189604446 0.642857142857143 5.5 5 5 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0195842716001316 0.0396104839936035 0.741262297326371 0.641025641025641 5.5 5 5 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.15277248886562e-14 9.90864223196727e-13 0.738935465002925 0.639013452914798 5.5 5 5 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.198882316196694 0.284431694419995 0.735871298800361 0.636363636363636 5.5 5 5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.198882316196694 0.284431694419995 0.735871298800361 0.636363636363636 5.5 5 5 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.198882316196694 0.284431694419995 0.735871298800361 0.636363636363636 5.5 5 5 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605568 SEROTONIN RECEPTORS 0.198882316196694 0.284431694419995 0.735871298800361 0.636363636363636 5.5 5 5 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.198882316196694 0.284431694419995 0.735871298800361 0.636363636363636 5.5 5 5 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.198882316196694 0.284431694419995 0.735871298800361 0.636363636363636 5.5 5 5 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0347164321549719 0.0625335227297785 0.735871298800361 0.636363636363636 5.5 5 5 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0347164321549719 0.0625335227297785 0.735871298800361 0.636363636363636 5.5 5 5 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0464117279949095 0.0789998671492299 0.732367149758454 0.633333333333333 5.5 5 5 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0464117279949095 0.0789998671492299 0.732367149758454 0.633333333333333 5.5 5 5 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0169349158363471 0.0349251959929303 0.729015355022718 0.630434782608696 5.5 5 5 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.04068088783317e-14 1.1310380136035e-12 0.72860659956714 0.630081300813008 5.5 5 5 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.01041564987728 0.0223551580322315 0.728084300929457 0.62962962962963 5.5 5 5 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0179714574053728 0.0369557570633605 0.722730739893211 0.625 5.5 5 5 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.0838443410599309 0.134661960867135 0.722730739893211 0.625 5.5 5 5 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.049195938825141 0.0836389736537343 0.722730739893211 0.625 5.5 5 5 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.148547394190801 0.218822921256221 0.722730739893211 0.625 5.5 5 5 CA ACTIVATED K+ CHANNELS%REACTOME%REACT_199092.2 CA ACTIVATED K+ CHANNELS 0.287214591289763 0.380545962202359 0.722730739893211 0.625 5.5 5 5 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.287214591289763 0.380545962202359 0.722730739893211 0.625 5.5 5 5 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.287214591289763 0.380545962202359 0.722730739893211 0.625 5.5 5 5 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.287214591289763 0.380545962202359 0.722730739893211 0.625 5.5 5 5 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.287214591289763 0.380545962202359 0.722730739893211 0.625 5.5 5 5 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.287214591289763 0.380545962202359 0.722730739893211 0.625 5.5 5 5 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0236374264607108 0.0451490709444181 0.719518603271464 0.622222222222222 5.5 5 5 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 7.18590004844861e-05 0.000245216685106532 0.714444654977238 0.617834394904459 5.5 5 5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.206502476166709 0.295033156210068 0.711611805433316 0.615384615384615 5.5 5 5 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0687155817985296 0.114098334771654 0.708742402992052 0.612903225806452 5.5 5 5 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.154470518545516 0.227312872689006 0.706670056784473 0.611111111111111 5.5 5 5 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0174519790824325 0.0359394590945027 0.701404259043903 0.60655737704918 5.5 5 5 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0714721029330934 0.118399071564368 0.700829808381296 0.606060606060606 5.5 5 5 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00736732188920037 0.0164321301697996 0.699531975402812 0.604938271604938 5.5 5 5 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 4.46689757321548e-06 1.9088274014071e-05 0.698356291410538 0.603921568627451 5.5 5 5 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0292699031783462 0.0544458460428583 0.693821510297483 0.6 5.5 5 5 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0739548571422964 0.120547884082111 0.693821510297483 0.6 5.5 5 5 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0945195821898886 0.149945780887638 0.693821510297483 0.6 5.5 5 5 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.121888590167112 0.185109353049948 0.693821510297483 0.6 5.5 5 5 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.291522382336445 0.384080935004801 0.693821510297483 0.6 5.5 5 5 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.00450268695797753 0.0106433945867143 0.689373936513525 0.596153846153846 5.5 5 5 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00685475958681365 0.0153129087787062 0.688900790366295 0.595744680851064 5.5 5 5 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0320232765144631 0.0593347948959388 0.682447387177852 0.590163934426229 5.5 5 5 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.215660302292828 0.297368808297185 0.680217166958317 0.588235294117647 5.5 5 5 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.215660302292828 0.297368808297185 0.680217166958317 0.588235294117647 5.5 5 5 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0141260672986664 0.0297798426162997 0.680217166958316 0.588235294117647 5.5 5 5 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0141260672986664 0.0297798426162997 0.680217166958316 0.588235294117647 5.5 5 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.127911912674065 0.194049735325367 0.677871590520529 0.586206896551724 5.5 5 5 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.101738223942349 0.156220544578638 0.674548690566997 0.583333333333333 5.5 5 5 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.293391409943934 0.384080935004801 0.674548690566997 0.583333333333333 5.5 5 5 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.293391409943934 0.384080935004801 0.674548690566997 0.583333333333333 5.5 5 5 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.293391409943934 0.384080935004801 0.674548690566997 0.583333333333333 5.5 5 5 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.293391409943934 0.384080935004801 0.674548690566997 0.583333333333333 5.5 5 5 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.293391409943934 0.384080935004801 0.674548690566997 0.583333333333333 5.5 5 5 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0350591737198052 0.0630710546185624 0.670358947147326 0.579710144927536 5.5 5 5 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000764058918990768 0.00218763750849872 0.669167954094019 0.578680203045685 5.5 5 5 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.170129292085206 0.248949428543848 0.660782390759508 0.571428571428571 5.5 5 5 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.293800945136509 0.38426355232468 0.660782390759508 0.571428571428571 5.5 5 5 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0259699126793583 0.0484340573299172 0.657304588702878 0.568421052631579 5.5 5 5 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.13642174175037 0.205862288982796 0.652310821647206 0.564102564102564 5.5 5 5 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0884358935247446 0.140923041977281 0.651771721794605 0.563636363636364 5.5 5 5 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.172681793289349 0.250485414730625 0.65045766590389 0.5625 5.5 5 5 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.293282145060454 0.384080935004801 0.65045766590389 0.5625 5.5 5 5 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.293282145060454 0.384080935004801 0.65045766590389 0.5625 5.5 5 5 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.293282145060454 0.384080935004801 0.65045766590389 0.5625 5.5 5 5 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.293282145060454 0.384080935004801 0.65045766590389 0.5625 5.5 5 5 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.293282145060454 0.384080935004801 0.65045766590389 0.5625 5.5 5 5 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00156283386167174 0.00402229156991343 0.650147481036983 0.562231759656652 5.5 5 5 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0335831199887127 0.0606456595735255 0.647566742944317 0.56 5.5 5 5 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.29214753197697 0.384080935004801 0.642427324349521 0.555555555555556 5.5 5 5 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 48%5605518 GLYCOPROTEIN HORMONES 0.411384855906617 0.527863525658355 0.642427324349521 0.555555555555556 5.5 5 5 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.411384855906617 0.527863525658355 0.642427324349521 0.555555555555556 5.5 5 5 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605114 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS 0.411384855906617 0.527863525658355 0.642427324349521 0.555555555555556 5.5 5 5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.411384855906617 0.527863525658355 0.642427324349521 0.555555555555556 5.5 5 5 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 48%5605119 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS 0.411384855906617 0.527863525658355 0.642427324349521 0.555555555555556 5.5 5 5 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.411384855906617 0.527863525658355 0.642427324349521 0.555555555555556 5.5 5 5 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0625797703691804 0.104153231854203 0.634137939519205 0.548387096774194 5.5 5 5 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0762452143802492 0.124138375358232 0.630746827543166 0.545454545454545 5.5 5 5 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.288744392311829 0.382216995590449 0.630746827543166 0.545454545454545 5.5 5 5 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.402690461704145 0.519518156849499 0.630746827543166 0.545454545454545 5.5 5 5 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.402690461704145 0.519518156849499 0.630746827543166 0.545454545454545 5.5 5 5 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.402690461704145 0.519518156849499 0.630746827543166 0.545454545454545 5.5 5 5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.402690461704145 0.519518156849499 0.630746827543166 0.545454545454545 5.5 5 5 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605466 PEPTIDE HORMONE BIOSYNTHESIS 0.402690461704145 0.519518156849499 0.630746827543166 0.545454545454545 5.5 5 5 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0305425078362864 0.0566649134954831 0.624870304305186 0.540372670807453 5.5 5 5 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.173507440183641 0.251426769227415 0.624439359267735 0.54 5.5 5 5 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.39476183268403 0.511608458933857 0.622660329754151 0.538461538461538 5.5 5 5 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.39476183268403 0.511608458933857 0.622660329754151 0.538461538461538 5.5 5 5 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.39476183268403 0.511608458933857 0.622660329754151 0.538461538461538 5.5 5 5 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.036402239781658 0.0653836891464616 0.621013080204537 0.537037037037037 5.5 5 5 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0303080221211935 0.0563032839144365 0.618813779454512 0.535135135135135 5.5 5 5 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0431047470040397 0.0756326202056085 0.617203184006963 0.533742331288344 5.5 5 5 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0821940761219947 0.132160644431185 0.604296154130066 0.52258064516129 5.5 5 5 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0813515846357341 0.130953964860463 0.603639259483135 0.522012578616352 5.5 5 5 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0813515846357341 0.130953964860463 0.603639259483135 0.522012578616352 5.5 5 5 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.260176247754514 0.352600762433022 0.603323052432594 0.521739130434783 5.5 5 5 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.362363238819066 0.471337192723519 0.603323052432594 0.521739130434783 5.5 5 5 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0364365885405088 0.0653836891464616 0.603125888036374 0.52156862745098 5.5 5 5 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.351619155098108 0.457780473654719 0.599598836059553 0.518518518518518 5.5 5 5 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0926091949037341 0.147408148040284 0.599337686740712 0.518292682926829 5.5 5 5 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.319872177235436 0.417594594684427 0.592286655131998 0.51219512195122 5.5 5 5 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.447501859030762 0.554699604007643 0.578184591914569 0.5 5.5 5 5 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.447501859030762 0.554699604007643 0.578184591914569 0.5 5.5 5 5 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.278881756355812 0.371581216567716 0.578184591914569 0.5 5.5 5 5 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.323231420177951 0.421593318893882 0.578184591914569 0.5 5.5 5 5 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.421050029165572 0.537898504545307 0.578184591914569 0.5 5.5 5 5 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.495722720231552 0.600351856076169 0.578184591914569 0.5 5.5 5 5 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.495722720231552 0.600351856076169 0.578184591914569 0.5 5.5 5 5 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.495722720231552 0.600351856076169 0.578184591914569 0.5 5.5 5 5 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.495722720231552 0.600351856076169 0.578184591914569 0.5 5.5 5 5 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.495722720231552 0.600351856076169 0.578184591914569 0.5 5.5 5 5 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.495722720231552 0.600351856076169 0.578184591914569 0.5 5.5 5 5 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.495722720231552 0.600351856076169 0.578184591914569 0.5 5.5 5 5 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.511989513464356 0.617424642084558 0.578184591914569 0.5 5.5 5 5 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.511989513464356 0.617424642084558 0.578184591914569 0.5 5.5 5 5 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198591.2 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.511989513464356 0.617424642084558 0.578184591914569 0.5 5.5 5 5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.42925338575482 0.546264090678242 0.578184591914569 0.5 5.5 5 5 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 UREA CYCLE%REACTOME DATABASE ID RELEASE 48%5604667 UREA CYCLE 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.531247329476789 0.635798948566418 0.578184591914569 0.5 5.5 5 5 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.268847026532472 0.364005060661949 0.570041146958026 0.492957746478873 5.5 5 5 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.271469508756674 0.367206379240254 0.569924812030075 0.492857142857143 5.5 5 5 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.304783646834282 0.398261826855082 0.565523615449287 0.489051094890511 5.5 5 5 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.337113181785136 0.439296756117443 0.561179162740611 0.485294117647059 5.5 5 5 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.367165988922548 0.477148129896608 0.557082964472431 0.481751824817518 5.5 5 5 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.501342314221768 0.606641252668007 0.556770347769585 0.481481481481481 5.5 5 5 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.10182484863191 0.156220544578638 0.552236795594501 0.477560975609756 5.5 5 5 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.539295826160163 0.644889042542783 0.550651992299589 0.476190476190476 5.5 5 5 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.451734285659059 0.559458562656954 0.548983349898682 0.474747474747475 5.5 5 5 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.571358793115766 0.678667414527324 0.544173733566653 0.470588235294118 5.5 5 5 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.571358793115766 0.678667414527324 0.544173733566653 0.470588235294118 5.5 5 5 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.54613260153263 0.652516114173747 0.542048054919908 0.46875 5.5 5 5 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.511120371973253 0.617424642084558 0.541590630400989 0.468354430379747 5.5 5 5 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.558113945002224 0.664043598443282 0.539638952453598 0.466666666666667 5.5 5 5 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.590472175999481 0.694989169931565 0.539638952453598 0.466666666666667 5.5 5 5 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.590472175999481 0.694989169931565 0.539638952453598 0.466666666666667 5.5 5 5 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.612470382704634 0.71969063136969 0.533708854074987 0.461538461538462 5.5 5 5 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.584284860580773 0.690941953292639 0.531304760137712 0.459459459459459 5.5 5 5 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.608722620833182 0.715877925161668 0.525622356285972 0.454545454545455 5.5 5 5 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.63837805262066 0.733181572945277 0.525622356285972 0.454545454545455 5.5 5 5 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.63837805262066 0.733181572945277 0.525622356285972 0.454545454545455 5.5 5 5 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.63837805262066 0.733181572945277 0.525622356285972 0.454545454545455 5.5 5 5 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.63837805262066 0.733181572945277 0.525622356285972 0.454545454545455 5.5 5 5 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.63837805262066 0.733181572945277 0.525622356285972 0.454545454545455 5.5 5 5 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.63837805262066 0.733181572945277 0.525622356285972 0.454545454545455 5.5 5 5 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.63837805262066 0.733181572945277 0.525622356285972 0.454545454545455 5.5 5 5 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.633549342167593 0.731770059987407 0.520366132723112 0.45 5.5 5 5 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.633549342167593 0.731770059987407 0.520366132723112 0.45 5.5 5 5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.653193104111502 0.749591763831183 0.513941859479617 0.444444444444444 5.5 5 5 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.676013543912699 0.772664476295398 0.511835540383389 0.442622950819672 5.5 5 5 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.667662244102752 0.765578866525557 0.508802440884821 0.44 5.5 5 5 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.915690394503139 0.976003571416041 0.497715602318212 0.430412371134021 5.5 5 5 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.700031129559446 0.798192545964016 0.495586793069631 0.428571428571429 5.5 5 5 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.700031129559446 0.798192545964016 0.495586793069631 0.428571428571429 5.5 5 5 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.700031129559446 0.798192545964016 0.495586793069631 0.428571428571429 5.5 5 5 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.720159367752127 0.806918724654549 0.495586793069631 0.428571428571429 5.5 5 5 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.914211884428631 0.976003571416041 0.491456903127384 0.425 5.5 5 5 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.894039923789605 0.961291081006656 0.49025790282157 0.423963133640553 5.5 5 5 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.725002346684392 0.811706010489292 0.486892287928058 0.421052631578947 5.5 5 5 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.728655580589449 0.815154788662567 0.481820493262141 0.416666666666667 5.5 5 5 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.78159792200101 0.869596437066018 0.476152016870822 0.411764705882353 5.5 5 5 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.822068334630473 0.90682421719315 0.471987421971077 0.408163265306122 5.5 5 5 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.773070431932756 0.860781865915737 0.462547673531655 0.4 5.5 5 5 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.811082350338947 0.895399677682174 0.462547673531655 0.4 5.5 5 5 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.917703990551414 0.976003571416041 0.453765122768396 0.392405063291139 5.5 5 5 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.850065366628355 0.922188885457332 0.447626780837086 0.387096774193548 5.5 5 5 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.850065366628355 0.922188885457332 0.447626780837086 0.387096774193548 5.5 5 5 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.984219236977955 1 0.446779002843076 0.386363636363636 5.5 5 5 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.801271329267457 0.886805746613874 0.444757378395822 0.384615384615385 5.5 5 5 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.896308780550682 0.962601807338581 0.442864793806904 0.382978723404255 5.5 5 5 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.920034380453623 0.977751249727786 0.436365729746845 0.377358490566038 5.5 5 5 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.831819155061744 0.916869603139319 0.433638443935927 0.375 5.5 5 5 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.856458165153584 0.924688899099811 0.426030751937051 0.368421052631579 5.5 5 5 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.856458165153584 0.924688899099811 0.426030751937051 0.368421052631579 5.5 5 5 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.857515884660797 0.925128964270139 0.412988994224692 0.357142857142857 5.5 5 5 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.894412783733529 0.961291081006656 0.404729214340198 0.35 5.5 5 5 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.899738611024817 0.965556593882591 0.385456394609713 0.333333333333333 5.5 5 5 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.923485502130213 0.980686469799473 0.385456394609713 0.333333333333333 5.5 5 5 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.994050214721211 1 0.374598468000988 0.323943661971831 5.5 5 5 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.945308863632761 1 0.36793564940018 0.318181818181818 5.5 5 5 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.945308863632761 1 0.36793564940018 0.318181818181818 5.5 5 5 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.999991652584202 1 0.360588240118763 0.311827956989247 5.5 5 5 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.984416583597711 1 0.335720085627814 0.290322580645161 5.5 5 5 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.316520868117799 0.273719563392107 5.5 5 5 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.996612862456602 1 0.304307679955036 0.263157894736842 5.5 5 5 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999009193178712 1 0.295243195871269 0.25531914893617 5.5 5 5 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.999319161066375 1 0.289092295957285 0.25 5.5 5 5 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.280205191018272 0.242314647377939 5.5 5 5 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.997456712192253 1 0.269819476226799 0.233333333333333 5.5 5 5 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.998330296218135 1 0.261115622154967 0.225806451612903 5.5 5 5 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.998381593712654 1 0.247793396534815 0.214285714285714 5.5 5 5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999938801832133 1 0.24091024663107 0.208333333333333 5.5 5 5 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.99999999879094 1 0.224849563522332 0.194444444444444 5.5 5 5 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999999997185667 1 0.205576743791847 0.177777777777778 5.5 5 5 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0130557811077483 0.0112903225806452 5.5 5 5 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 2.84979499561824e-05 0.000229110637218348 3.45840452096202 1 6.1 6 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.000127133166725476 0.000873963750001702 3.45840452096202 1 6.1 6 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 1.14279097823873e-05 0.000100382195187266 3.11256406886582 0.9 6.1 6 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.000183271805889154 0.00120407652879804 3.02610395584177 0.875 6.1 6 1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.000718944467341237 0.00386059613972294 2.96434673225316 0.857142857142857 6.1 6 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.00276693533588452 0.0114293564129078 2.88200376746835 0.833333333333333 6.1 6 1 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME DATABASE ID RELEASE 48%5605065 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT 0.00276693533588452 0.0114293564129078 2.88200376746835 0.833333333333333 6.1 6 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 5.0209184550053e-05 0.000390424424124183 2.82960369896892 0.818181818181818 6.1 6 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 1.00469364163521e-06 1.16498171017661e-05 2.80995367328164 0.8125 6.1 6 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000184461478059011 0.00120407652879804 2.76672361676961 0.8 6.1 6 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.000184461478059011 0.00120407652879804 2.76672361676961 0.8 6.1 6 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.000184461478059011 0.00120407652879804 2.76672361676961 0.8 6.1 6 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000663601944469197 0.00361802899225926 2.68987018297046 0.777777777777778 6.1 6 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.000663601944469197 0.00361802899225926 2.68987018297046 0.777777777777778 6.1 6 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00232596245169749 0.0099995304192312 2.59380339072151 0.75 6.1 6 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00232596245169749 0.0099995304192312 2.59380339072151 0.75 6.1 6 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00232596245169749 0.0099995304192312 2.59380339072151 0.75 6.1 6 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00232596245169749 0.0099995304192312 2.59380339072151 0.75 6.1 6 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.00232596245169749 0.0099995304192312 2.59380339072151 0.75 6.1 6 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.00232596245169749 0.0099995304192312 2.59380339072151 0.75 6.1 6 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00232596245169749 0.0099995304192312 2.59380339072151 0.75 6.1 6 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 5.63477687093386e-08 1.14546964104841e-06 2.52729561147224 0.730769230769231 6.1 6 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 9.66656961748419e-06 8.59720535355001e-05 2.49773659847257 0.722222222222222 6.1 6 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.000129537261240571 0.000881969008350872 2.4702889435443 0.714285714285714 6.1 6 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000129537261240571 0.000881969008350872 2.4702889435443 0.714285714285714 6.1 6 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00788691250724275 0.0275075404358001 2.4702889435443 0.714285714285714 6.1 6 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00788691250724275 0.0275075404358001 2.4702889435443 0.714285714285714 6.1 6 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00788691250724275 0.0275075404358001 2.4702889435443 0.714285714285714 6.1 6 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.00788691250724275 0.0275075404358001 2.4702889435443 0.714285714285714 6.1 6 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 3.14194666204481e-05 0.000249775983245238 2.44122672067907 0.705882352941177 6.1 6 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 7.70579175324328e-06 7.06949992189427e-05 2.42088316467341 0.7 6.1 6 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 7.70579175324328e-06 7.06949992189427e-05 2.42088316467341 0.7 6.1 6 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 7.70579175324328e-06 7.06949992189427e-05 2.42088316467341 0.7 6.1 6 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00178159636609296 0.00804829088555647 2.42088316467341 0.7 6.1 6 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.00178159636609296 0.00804829088555647 2.42088316467341 0.7 6.1 6 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.000417354617099666 0.00246429717897438 2.39428005297371 0.692307692307692 6.1 6 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.000417354617099666 0.00246429717897438 2.39428005297371 0.692307692307692 6.1 6 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.97915086553483e-08 6.6176193969014e-07 2.37765310816139 0.6875 6.1 6 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 9.99429615351624e-05 0.000707556389375801 2.37765310816139 0.6875 6.1 6 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 2.4288473575325e-05 0.000198813168614636 2.36627677750033 0.684210526315789 6.1 6 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 5.96527068500253e-06 5.7745443433732e-05 2.3580030824741 0.681818181818182 6.1 6 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00031015517137568 0.0019230725478739 2.30560301397468 0.666666666666667 6.1 6 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00031015517137568 0.0019230725478739 2.30560301397468 0.666666666666667 6.1 6 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.00031015517137568 0.0019230725478739 2.30560301397468 0.666666666666667 6.1 6 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00130632235606964 0.00600332263113579 2.30560301397468 0.666666666666667 6.1 6 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00130632235606964 0.00600332263113579 2.30560301397468 0.666666666666667 6.1 6 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00130632235606964 0.00600332263113579 2.30560301397468 0.666666666666667 6.1 6 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00565068346615407 0.021041243549419 2.30560301397468 0.666666666666667 6.1 6 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.00565068346615407 0.021041243549419 2.30560301397468 0.666666666666667 6.1 6 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00565068346615407 0.021041243549419 2.30560301397468 0.666666666666667 6.1 6 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 3.37026222967373e-06 3.37738250198994e-05 2.26126449447517 0.653846153846154 6.1 6 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.50848826734768e-05 0.000420741692911633 2.24796293862531 0.65 6.1 6 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 5.50848826734768e-05 0.000420741692911633 2.24796293862531 0.65 6.1 6 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 5.50848826734768e-05 0.000420741692911633 2.24796293862531 0.65 6.1 6 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000935425857646039 0.00487586445212569 2.22326004918987 0.642857142857143 6.1 6 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.000935425857646039 0.00487586445212569 2.22326004918987 0.642857142857143 6.1 6 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.000935425857646039 0.00487586445212569 2.22326004918987 0.642857142857143 6.1 6 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00395007171711059 0.0157891911613718 2.20080287697583 0.636363636363636 6.1 6 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000660508854443211 0.00361802899225926 2.16150282560126 0.625 6.1 6 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000660508854443211 0.00361802899225926 2.16150282560126 0.625 6.1 6 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000660508854443211 0.00361802899225926 2.16150282560126 0.625 6.1 6 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000660508854443211 0.00361802899225926 2.16150282560126 0.625 6.1 6 1 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0171551625998182 0.0510707037228896 2.16150282560126 0.625 6.1 6 1 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.0171551625998182 0.0510707037228896 2.16150282560126 0.625 6.1 6 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0171551625998182 0.0510707037228896 2.16150282560126 0.625 6.1 6 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 9.41640735940908e-07 1.13042304877916e-05 2.13607338059419 0.617647058823529 6.1 6 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0027286707384216 0.0113535042712688 2.12824893597663 0.615384615384615 6.1 6 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0027286707384216 0.0113535042712688 2.12824893597663 0.615384615384615 6.1 6 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0027286707384216 0.0113535042712688 2.12824893597663 0.615384615384615 6.1 6 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 6.73525324186339e-07 8.71296851197418e-06 2.11346942947679 0.611111111111111 6.1 6 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 8.09564180617131e-05 0.00058477656295339 2.10511579536819 0.608695652173913 6.1 6 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 1.85519022206099e-06 1.91299687390782e-05 2.07504271257721 0.6 6.1 6 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 1.85519022206099e-06 1.91299687390782e-05 2.07504271257721 0.6 6.1 6 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 5.678552149207e-05 0.000427543899911194 2.07504271257721 0.6 6.1 6 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00187333188705158 0.00838286564551697 2.07504271257721 0.6 6.1 6 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00187333188705158 0.00838286564551697 2.07504271257721 0.6 6.1 6 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00187333188705158 0.00838286564551697 2.07504271257721 0.6 6.1 6 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000321700629203085 0.00195632476647859 2.07504271257721 0.6 6.1 6 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000321700629203085 0.00195632476647859 2.07504271257721 0.6 6.1 6 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0114543141162457 0.0359019581220654 2.07504271257721 0.6 6.1 6 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.0114543141162457 0.0359019581220654 2.07504271257721 0.6 6.1 6 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0114543141162457 0.0359019581220654 2.07504271257721 0.6 6.1 6 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0114543141162457 0.0359019581220654 2.07504271257721 0.6 6.1 6 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0114543141162457 0.0359019581220654 2.07504271257721 0.6 6.1 6 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0114543141162457 0.0359019581220654 2.07504271257721 0.6 6.1 6 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0114543141162457 0.0359019581220654 2.07504271257721 0.6 6.1 6 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 6.9521022781698e-13 7.06631538702545e-11 2.04170869309806 0.590361445783133 6.1 6 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00128185097667807 0.00600024322306873 2.03435560056589 0.588235294117647 6.1 6 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0076513208225679 0.0270169467258415 2.01740263722784 0.583333333333333 6.1 6 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 1.92186110168181e-05 0.000160871079276071 2.00810585088117 0.580645161290323 6.1 6 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 3.16350725723346e-07 4.45709982875565e-06 1.99818927877806 0.577777777777778 6.1 6 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.000106365473217196 0.000741951315627797 1.99523337747809 0.576923076923077 6.1 6 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000106365473217196 0.000741951315627797 1.99523337747809 0.576923076923077 6.1 6 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 1.3336990242855e-05 0.000115021437064138 1.99120260297813 0.575757575757576 6.1 6 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000597532800193901 0.00341148993680673 1.97623115483544 0.571428571428571 6.1 6 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00511966391278903 0.0193243547689623 1.97623115483544 0.571428571428571 6.1 6 1 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.00511966391278903 0.0193243547689623 1.97623115483544 0.571428571428571 6.1 6 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00511966391278903 0.0193243547689623 1.97623115483544 0.571428571428571 6.1 6 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00511966391278903 0.0193243547689623 1.97623115483544 0.571428571428571 6.1 6 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00511966391278903 0.0193243547689623 1.97623115483544 0.571428571428571 6.1 6 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 6.39830260837102e-06 6.06985640780798e-05 1.96287824162709 0.567567567567568 6.1 6 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000407637228146185 0.0024270618228118 1.95475038141332 0.565217391304348 6.1 6 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 9.06462488797548e-10 2.68728358658107e-08 1.95475038141331 0.565217391304348 6.1 6 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00343267578611949 0.0138769819421819 1.94535254304114 0.5625 6.1 6 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00230629491664559 0.0099995304192312 1.9213358449789 0.555555555555556 6.1 6 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0315357615168982 0.0840363083118842 1.9213358449789 0.555555555555556 6.1 6 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0315357615168982 0.0840363083118842 1.9213358449789 0.555555555555556 6.1 6 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0315357615168982 0.0840363083118842 1.9213358449789 0.555555555555556 6.1 6 1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0315357615168982 0.0840363083118842 1.9213358449789 0.555555555555556 6.1 6 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.000189723211394033 0.00122716422642595 1.9213358449789 0.555555555555556 6.1 6 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.00697646065863e-06 1.16498171017661e-05 1.91315994776622 0.553191489361702 6.1 6 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 6.94829473449071e-07 8.90758865511737e-06 1.90565147073417 0.551020408163265 6.1 6 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 7.75011938029168e-06 7.06949992189427e-05 1.90212248652911 0.55 6.1 6 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.02280576808567e-08 6.6176193969014e-07 1.89654441472111 0.548387096774194 6.1 6 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00104698229696933 0.00535919355606962 1.88640246597928 0.545454545454545 6.1 6 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00104698229696933 0.00535919355606962 1.88640246597928 0.545454545454545 6.1 6 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0204594049952079 0.0591742546914246 1.88640246597928 0.545454545454545 6.1 6 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.0204594049952079 0.0591742546914246 1.88640246597928 0.545454545454545 6.1 6 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0204594049952079 0.0591742546914246 1.88640246597928 0.545454545454545 6.1 6 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0204594049952079 0.0591742546914246 1.88640246597928 0.545454545454545 6.1 6 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0204594049952079 0.0591742546914246 1.88640246597928 0.545454545454545 6.1 6 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0204594049952079 0.0591742546914246 1.88640246597928 0.545454545454545 6.1 6 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0204594049952079 0.0591742546914246 1.88640246597928 0.545454545454545 6.1 6 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.51463476831686e-06 2.55594662522492e-05 1.87956767443588 0.543478260869565 6.1 6 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.72803659055119e-06 1.8080853443782e-05 1.87330244885443 0.541666666666667 6.1 6 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000707208448143814 0.0038264548353941 1.87330244885443 0.541666666666667 6.1 6 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000478407686346678 0.00279005794127591 1.86221781897955 0.538461538461538 6.1 6 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000478407686346678 0.00279005794127591 1.86221781897955 0.538461538461538 6.1 6 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0133944125874052 0.0410700723521515 1.86221781897955 0.538461538461538 6.1 6 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0133944125874052 0.0410700723521515 1.86221781897955 0.538461538461538 6.1 6 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0133944125874052 0.0410700723521515 1.86221781897955 0.538461538461538 6.1 6 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0133944125874052 0.0410700723521515 1.86221781897955 0.538461538461538 6.1 6 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0133944125874052 0.0410700723521515 1.86221781897955 0.538461538461538 6.1 6 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0133944125874052 0.0410700723521515 1.86221781897955 0.538461538461538 6.1 6 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.08413812180552e-09 3.14842560679441e-08 1.85889243001708 0.5375 6.1 6 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000324064761601936 0.00196231555642364 1.85271670765822 0.535714285714286 6.1 6 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.01576863402658e-09 1.96662737348618e-07 1.84764077147286 0.534246575342466 6.1 6 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.82293577492353e-07 3.32568924066177e-06 1.84448241117974 0.533333333333333 6.1 6 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.82293577492353e-07 3.32568924066177e-06 1.84448241117974 0.533333333333333 6.1 6 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.82293577492353e-07 3.32568924066177e-06 1.84448241117974 0.533333333333333 6.1 6 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.82293577492353e-07 3.32568924066177e-06 1.84448241117974 0.533333333333333 6.1 6 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.82293577492353e-07 3.32568924066177e-06 1.84448241117974 0.533333333333333 6.1 6 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.82293577492353e-07 3.32568924066177e-06 1.84448241117974 0.533333333333333 6.1 6 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.82293577492353e-07 3.32568924066177e-06 1.84448241117974 0.533333333333333 6.1 6 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00882975765648896 0.0302037142913072 1.84448241117974 0.533333333333333 6.1 6 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00882975765648896 0.0302037142913072 1.84448241117974 0.533333333333333 6.1 6 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00882975765648896 0.0302037142913072 1.84448241117974 0.533333333333333 6.1 6 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00014922415150227 0.00100163192258364 1.83727740176107 0.53125 6.1 6 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.89600985336232e-06 2.92271065342878e-05 1.83507178663291 0.530612244897959 6.1 6 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00585235369674107 0.0215191196652779 1.8309200405093 0.529411764705882 6.1 6 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00585235369674107 0.0215191196652779 1.8309200405093 0.529411764705882 6.1 6 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00585235369674107 0.0215191196652779 1.8309200405093 0.529411764705882 6.1 6 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00585235369674107 0.0215191196652779 1.8309200405093 0.529411764705882 6.1 6 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.36007967375126e-06 1.53602648868892e-05 1.82708163371578 0.528301886792453 6.1 6 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 6.89932372255975e-05 0.000511340502979298 1.82526905272995 0.527777777777778 6.1 6 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00260301928205454 0.0109913840900997 1.81154522526582 0.523809523809524 6.1 6 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.48912837988041e-05 0.000126132719319633 1.80780236323015 0.522727272727273 6.1 6 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.01667663897655e-05 8.9859059457368e-05 1.80438496745844 0.521739130434783 6.1 6 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.06455947361912e-12 9.46792581850002e-11 1.80065689934386 0.520661157024793 6.1 6 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.06455947361912e-12 9.46792581850002e-11 1.80065689934386 0.520661157024793 6.1 6 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.15537792626347e-08 6.80318604404987e-07 1.80026536707612 0.520547945205479 6.1 6 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00117210056441624 0.0058522775549625 1.79837035090025 0.52 6.1 6 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00117210056441624 0.0058522775549625 1.79837035090025 0.52 6.1 6 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00117210056441624 0.0058522775549625 1.79837035090025 0.52 6.1 6 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00117210056441624 0.0058522775549625 1.79837035090025 0.52 6.1 6 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.51980839114914e-06 1.60199062267054e-05 1.79095948406962 0.517857142857143 6.1 6 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.32882781557007e-09 8.77207774362261e-08 1.79023292849799 0.517647058823529 6.1 6 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.32882781557007e-09 8.77207774362261e-08 1.79023292849799 0.517647058823529 6.1 6 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.32882781557007e-09 8.77207774362261e-08 1.79023292849799 0.517647058823529 6.1 6 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.000243637944329221 0.00154775354812715 1.78160232898043 0.515151515151515 6.1 6 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000165138844626202 0.00109809614907984 1.7786080393519 0.514285714285714 6.1 6 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.4902689422407e-08 7.41291448478883e-07 1.77470758312525 0.513157894736842 6.1 6 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 7.61338984333057e-05 0.000552747640156092 1.77354077998052 0.512820512820513 6.1 6 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.40044419744982e-05 0.000198594889126226 1.76762897738059 0.511111111111111 6.1 6 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 7.79210044772712e-07 9.81253003284574e-06 1.75664991540928 0.507936507936508 6.1 6 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.7427976987719e-09 7.65294338304395e-08 1.74779583317435 0.505376344086022 6.1 6 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 2.89720874722326e-10 1.52693631381433e-08 1.74567085343797 0.504761904761905 6.1 6 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.55863937226893e-05 0.000420741692911633 1.72920226048101 0.5 6.1 6 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.55863937226893e-05 0.000420741692911633 1.72920226048101 0.5 6.1 6 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000845321814971684 0.00450521701387531 1.72920226048101 0.5 6.1 6 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000845321814971684 0.00450521701387531 1.72920226048101 0.5 6.1 6 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00415905626713978 0.0164064852805758 1.72920226048101 0.5 6.1 6 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 2.69450205356495e-07 3.83427642222292e-06 1.72920226048101 0.5 6.1 6 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00125453255714328 0.00593798317562766 1.72920226048101 0.5 6.1 6 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00125453255714328 0.00593798317562766 1.72920226048101 0.5 6.1 6 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00939841247683653 0.0312886336834096 1.72920226048101 0.5 6.1 6 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00939841247683653 0.0312886336834096 1.72920226048101 0.5 6.1 6 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0216691612620215 0.0610645281651337 1.72920226048101 0.5 6.1 6 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0216691612620215 0.0610645281651337 1.72920226048101 0.5 6.1 6 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0216691612620215 0.0610645281651337 1.72920226048101 0.5 6.1 6 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0216691612620215 0.0610645281651337 1.72920226048101 0.5 6.1 6 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.0216691612620215 0.0610645281651337 1.72920226048101 0.5 6.1 6 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0216691612620215 0.0610645281651337 1.72920226048101 0.5 6.1 6 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0332674891678479 0.0868481106343259 1.72920226048101 0.5 6.1 6 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.51647883548225e-12 2.77997187938402e-10 1.72920226048101 0.5 6.1 6 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000120260652319298 0.000830732564322139 1.72920226048101 0.5 6.1 6 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0142268395268584 0.0431658691827709 1.72920226048101 0.5 6.1 6 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0142268395268584 0.0431658691827709 1.72920226048101 0.5 6.1 6 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0516172089175507 0.119627505357776 1.72920226048101 0.5 6.1 6 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.52808871747483e-11 2.09186260206945e-09 1.71514370551775 0.495934959349593 6.1 6 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 4.34987070612016e-08 9.10274413942498e-07 1.70885870447535 0.494117647058824 6.1 6 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.29613569586995e-06 1.48742023808302e-05 1.70339327151861 0.492537313432836 6.1 6 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.71551769311634e-05 0.000219555777119577 1.69529633380491 0.490196078431373 6.1 6 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.71551769311634e-05 0.000219555777119577 1.69529633380491 0.490196078431373 6.1 6 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000185486717349692 0.00120524017711695 1.68702659559123 0.48780487804878 6.1 6 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.000594311459115012 0.00341010163838977 1.67979648161012 0.485714285714286 6.1 6 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.95957180532192e-11 3.39218827158924e-09 1.67599603708159 0.484615384615385 6.1 6 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.02597846357453e-11 1.31043970621207e-09 1.66700074031982 0.482014388489209 6.1 6 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00286539574109092 0.0116832611449065 1.66515773231505 0.481481481481481 6.1 6 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.53069594060708e-07 6.08224558819233e-06 1.66353635185515 0.481012658227848 6.1 6 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.53069594060708e-07 6.08224558819233e-06 1.66353635185515 0.481012658227848 6.1 6 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 4.53069594060708e-07 6.08224558819233e-06 1.66353635185515 0.481012658227848 6.1 6 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 2.25122744833352e-16 5.33916109829766e-14 1.66332788865316 0.480952380952381 6.1 6 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 7.6012382785312e-09 1.92895243187499e-07 1.66269448123174 0.480769230769231 6.1 6 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 9.61217068884598e-07 1.13042304877916e-05 1.66003417006177 0.48 6.1 6 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 9.61217068884598e-07 1.13042304877916e-05 1.66003417006177 0.48 6.1 6 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 9.61217068884598e-07 1.13042304877916e-05 1.66003417006177 0.48 6.1 6 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 9.61217068884598e-07 1.13042304877916e-05 1.66003417006177 0.48 6.1 6 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 9.61217068884598e-07 1.13042304877916e-05 1.66003417006177 0.48 6.1 6 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 6.03453930621761e-05 0.000451629632324039 1.66003417006177 0.48 6.1 6 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00426746648170993 0.016501643487699 1.66003417006177 0.48 6.1 6 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00637244567097287 0.0227711756854628 1.65401955350357 0.478260869565217 6.1 6 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00637244567097287 0.0227711756854628 1.65401955350357 0.478260869565217 6.1 6 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.32527911823959e-12 1.94639540309114e-10 1.65210407052326 0.477707006369427 6.1 6 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 6.32957332489299e-06 6.04495492706223e-05 1.64939292538189 0.476923076923077 6.1 6 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 1.96838784200226e-05 0.000163802099366621 1.64127672181248 0.474576271186441 6.1 6 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0143505955737676 0.0432646133505749 1.63819161519254 0.473684210526316 6.1 6 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0143505955737676 0.0432646133505749 1.63819161519254 0.473684210526316 6.1 6 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0143505955737676 0.0432646133505749 1.63819161519254 0.473684210526316 6.1 6 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000892282991772884 0.00472014385610712 1.63313546823206 0.472222222222222 6.1 6 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 2.24455741634566e-07 3.83427642222292e-06 1.63205606607196 0.471910112359551 6.1 6 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 5.11154037867382e-12 3.63686097942642e-10 1.63132288724624 0.471698113207547 6.1 6 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00131625907302485 0.00600332263113579 1.62748448045271 0.470588235294118 6.1 6 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00131625907302485 0.00600332263113579 1.62748448045271 0.470588235294118 6.1 6 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00131625907302485 0.00600332263113579 1.62748448045271 0.470588235294118 6.1 6 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00131625907302485 0.00600332263113579 1.62748448045271 0.470588235294118 6.1 6 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00131625907302485 0.00600332263113579 1.62748448045271 0.470588235294118 6.1 6 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0216708269314073 0.0610645281651337 1.62748448045271 0.470588235294118 6.1 6 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0216708269314073 0.0610645281651337 1.62748448045271 0.470588235294118 6.1 6 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0216708269314073 0.0610645281651337 1.62748448045271 0.470588235294118 6.1 6 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0216708269314073 0.0610645281651337 1.62748448045271 0.470588235294118 6.1 6 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0216708269314073 0.0610645281651337 1.62748448045271 0.470588235294118 6.1 6 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.36669351855258e-05 0.000116908600673358 1.62112711920095 0.46875 6.1 6 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000192519791059959 0.00123403451656902 1.61882764810988 0.468085106382979 6.1 6 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.79002213528399e-13 3.30850124875759e-11 1.61642820001486 0.467391304347826 6.1 6 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0329036394168624 0.0868481106343259 1.61392210978228 0.466666666666667 6.1 6 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0329036394168624 0.0868481106343259 1.61392210978228 0.466666666666667 6.1 6 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0042614771671789 0.016501643487699 1.60568781330379 0.464285714285714 6.1 6 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0042614771671789 0.016501643487699 1.60568781330379 0.464285714285714 6.1 6 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.94550608886011e-09 1.02081002989963e-07 1.60267526581167 0.463414634146341 6.1 6 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000606598349343202 0.00341181601231374 1.60267526581167 0.463414634146341 6.1 6 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000606598349343202 0.00341181601231374 1.60267526581167 0.463414634146341 6.1 6 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000606598349343202 0.00341181601231374 1.60267526581167 0.463414634146341 6.1 6 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.37201239019331e-05 0.000116908600673358 1.60015731566899 0.462686567164179 6.1 6 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 2.30842692696376e-11 1.42821370307367e-09 1.59951209094493 0.4625 6.1 6 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00632604337247345 0.0227711756854628 1.59618670198247 0.461538461538462 6.1 6 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00632604337247345 0.0227711756854628 1.59618670198247 0.461538461538462 6.1 6 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00632604337247345 0.0227711756854628 1.59618670198247 0.461538461538462 6.1 6 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00632604337247345 0.0227711756854628 1.59618670198247 0.461538461538462 6.1 6 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00632604337247345 0.0227711756854628 1.59618670198247 0.461538461538462 6.1 6 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0503015548082273 0.118316770401186 1.59618670198247 0.461538461538462 6.1 6 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0503015548082273 0.118316770401186 1.59618670198247 0.461538461538462 6.1 6 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0503015548082273 0.118316770401186 1.59618670198247 0.461538461538462 6.1 6 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0503015548082273 0.118316770401186 1.59618670198247 0.461538461538462 6.1 6 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.00306423088856e-10 5.48984769444009e-09 1.5926862925483 0.460526315789474 6.1 6 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.2893173819141e-10 2.68728358658107e-08 1.5923589161264 0.460431654676259 6.1 6 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.45985372142996e-06 1.55027749671256e-05 1.5867973684414 0.458823529411765 6.1 6 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.45985372142996e-06 1.55027749671256e-05 1.5867973684414 0.458823529411765 6.1 6 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 1.45985372142996e-06 1.55027749671256e-05 1.5867973684414 0.458823529411765 6.1 6 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.45985372142996e-06 1.55027749671256e-05 1.5867973684414 0.458823529411765 6.1 6 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.45985372142996e-06 1.55027749671256e-05 1.5867973684414 0.458823529411765 6.1 6 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.45985372142996e-06 1.55027749671256e-05 1.5867973684414 0.458823529411765 6.1 6 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 1.45985372142996e-06 1.55027749671256e-05 1.5867973684414 0.458823529411765 6.1 6 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00941077668060386 0.0312886336834096 1.58510207210759 0.458333333333333 6.1 6 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00941077668060386 0.0312886336834096 1.58510207210759 0.458333333333333 6.1 6 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00941077668060386 0.0312886336834096 1.58510207210759 0.458333333333333 6.1 6 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 4.78592788150454e-07 6.30590312535274e-06 1.58203611065284 0.457446808510638 6.1 6 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 9.05638807467257e-10 2.68728358658107e-08 1.58098492386835 0.457142857142857 6.1 6 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.05638807467257e-10 2.68728358658107e-08 1.58098492386835 0.457142857142857 6.1 6 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.4383726141107e-06 4.41664631460107e-05 1.57598180702067 0.455696202531646 6.1 6 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.44861801721331e-06 1.55027749671256e-05 1.57200205498274 0.454545454545455 6.1 6 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000130218417683471 0.000882384801731332 1.57200205498274 0.454545454545455 6.1 6 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000599348196909124 0.00341148993680673 1.57200205498274 0.454545454545455 6.1 6 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0775820455195032 0.164998009293982 1.57200205498274 0.454545454545455 6.1 6 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00283242847211108 0.0115820279190059 1.57200205498274 0.454545454545455 6.1 6 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00283242847211108 0.0115820279190059 1.57200205498274 0.454545454545455 6.1 6 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 6.06192971004156e-05 0.000451629632324039 1.56186010624091 0.451612903225806 6.1 6 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00417368072492511 0.0164064852805758 1.56186010624091 0.451612903225806 6.1 6 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00417368072492511 0.0164064852805758 1.56186010624091 0.451612903225806 6.1 6 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000276062699847908 0.00173821779594502 1.55967262710052 0.450980392156863 6.1 6 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0209869896452526 0.0605770512478588 1.55628203443291 0.45 6.1 6 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0061571181760206 0.0224655876012239 1.55031926801746 0.448275862068966 6.1 6 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0061571181760206 0.0224655876012239 1.55031926801746 0.448275862068966 6.1 6 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.02140409953453e-06 2.06939426880406e-05 1.54124549303742 0.445652173913043 6.1 6 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.16798398936229e-07 3.83427642222292e-06 1.54056201388308 0.445454545454545 6.1 6 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 4.98671465956864e-16 1.01372785150945e-13 1.53848142292796 0.444852941176471 6.1 6 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 8.95076194257216e-06 8.01065046810074e-05 1.53706867598312 0.444444444444444 6.1 6 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 8.95076194257216e-06 8.01065046810074e-05 1.53706867598312 0.444444444444444 6.1 6 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 8.95076194257216e-06 8.01065046810074e-05 1.53706867598312 0.444444444444444 6.1 6 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.000853182729161564 0.00453014561043621 1.53706867598312 0.444444444444444 6.1 6 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00909456147757952 0.0305947068146469 1.53706867598312 0.444444444444444 6.1 6 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00909456147757952 0.0305947068146469 1.53706867598312 0.444444444444444 6.1 6 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00909456147757952 0.0305947068146469 1.53706867598312 0.444444444444444 6.1 6 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00909456147757952 0.0305947068146469 1.53706867598312 0.444444444444444 6.1 6 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00909456147757952 0.0305947068146469 1.53706867598312 0.444444444444444 6.1 6 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00909456147757952 0.0305947068146469 1.53706867598312 0.444444444444444 6.1 6 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00909456147757952 0.0305947068146469 1.53706867598312 0.444444444444444 6.1 6 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0314887584950638 0.0840363083118842 1.53706867598312 0.444444444444444 6.1 6 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0314887584950638 0.0840363083118842 1.53706867598312 0.444444444444444 6.1 6 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0314887584950638 0.0840363083118842 1.53706867598312 0.444444444444444 6.1 6 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0314887584950638 0.0840363083118842 1.53706867598312 0.444444444444444 6.1 6 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0314887584950638 0.0840363083118842 1.53706867598312 0.444444444444444 6.1 6 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000390675101128128 0.00233584314666103 1.5296789227332 0.442307692307692 6.1 6 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0012431314308827 0.00593798317562766 1.52813223019252 0.441860465116279 6.1 6 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00402940431349496 0.0160611830198973 1.52576670042442 0.441176470588235 6.1 6 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.72106618323562e-08 9.73634373731055e-07 1.52496577302262 0.440944881889764 6.1 6 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.33181508635598e-06 1.51613829430765e-05 1.52169798922329 0.44 6.1 6 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000567029214263383 0.00326673106031091 1.52169798922329 0.44 6.1 6 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0134519489797348 0.0410700723521515 1.52169798922329 0.44 6.1 6 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.60446748064075e-09 4.56631444990356e-08 1.51305197792088 0.4375 6.1 6 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0474300393313098 0.117583529561766 1.51305197792088 0.4375 6.1 6 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0474300393313098 0.117583529561766 1.51305197792088 0.4375 6.1 6 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0474300393313098 0.117583529561766 1.51305197792088 0.4375 6.1 6 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00264009859474426 0.0111149713027251 1.50750966298344 0.435897435897436 6.1 6 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.20971623597636e-05 0.000105413396162459 1.50542314441876 0.435294117647059 6.1 6 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0199271843941602 0.0584667698822474 1.5036541395487 0.434782608695652 6.1 6 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.00866616501418743 0.0298594499157112 1.49864195908354 0.433333333333333 6.1 6 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00866616501418743 0.0298594499157112 1.49864195908354 0.433333333333333 6.1 6 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00384788481596151 0.0154240566003189 1.49552627933493 0.432432432432432 6.1 6 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00384788481596151 0.0154240566003189 1.49552627933493 0.432432432432432 6.1 6 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 5.44047477797513e-06 5.30259973223192e-05 1.49257458273098 0.431578947368421 6.1 6 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.000360891464119842 0.00216687153351281 1.49069160386294 0.431034482758621 6.1 6 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.000360891464119842 0.00216687153351281 1.49069160386294 0.431034482758621 6.1 6 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00251277564007449 0.0107701196862229 1.48217336612658 0.428571428571429 6.1 6 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0295682637159787 0.0801440747958812 1.48217336612658 0.428571428571429 6.1 6 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0295682637159787 0.0801440747958812 1.48217336612658 0.428571428571429 6.1 6 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.0717758499678818 0.160340713507529 1.48217336612658 0.428571428571429 6.1 6 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0717758499678818 0.160340713507529 1.48217336612658 0.428571428571429 6.1 6 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0717758499678818 0.160340713507529 1.48217336612658 0.428571428571429 6.1 6 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0717758499678818 0.160340713507529 1.48217336612658 0.428571428571429 6.1 6 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0717758499678818 0.160340713507529 1.48217336612658 0.428571428571429 6.1 6 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 5.15988593881307e-07 6.73625476232202e-06 1.47407405811496 0.426229508196721 6.1 6 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 8.59272675930007e-10 2.68728358658107e-08 1.47407405811496 0.426229508196721 6.1 6 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 7.10072532419164e-06 6.68789909555691e-05 1.46720191798389 0.424242424242424 6.1 6 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00817366721343313 0.0283686059627203 1.46720191798389 0.424242424242424 6.1 6 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00817366721343313 0.0283686059627203 1.46720191798389 0.424242424242424 6.1 6 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.000150613024580072 0.00100620814073916 1.46129768491353 0.422535211267606 6.1 6 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00528091083208264 0.0198802542699831 1.45617032461559 0.421052631578947 6.1 6 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0439528769832791 0.109920815372946 1.45617032461559 0.421052631578947 6.1 6 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0439528769832791 0.109920815372946 1.45617032461559 0.421052631578947 6.1 6 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.50250692524279e-06 4.44935232959756e-05 1.45446919105879 0.420560747663551 6.1 6 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 9.43833683645475e-07 1.13042304877916e-05 1.45029867008085 0.419354838709677 6.1 6 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0119107370008769 0.0371688130531752 1.45029867008085 0.419354838709677 6.1 6 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00342691947069257 0.0138769819421819 1.44770421807712 0.418604651162791 6.1 6 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.2525792711441e-25 5.94140100946016e-23 1.44756336341493 0.418563922942207 6.1 6 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 9.43366230929892e-05 0.000671205073306619 1.44464998976894 0.417721518987342 6.1 6 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.000203211724548551 0.00129672773108784 1.44100188373417 0.416666666666667 6.1 6 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00223188761146564 0.00983274325422787 1.44100188373417 0.416666666666667 6.1 6 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0274389041895576 0.0750876166571932 1.44100188373417 0.416666666666667 6.1 6 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0274389041895576 0.0750876166571932 1.44100188373417 0.416666666666667 6.1 6 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.1092353000564 0.218317179747551 1.44100188373417 0.416666666666667 6.1 6 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.1092353000564 0.218317179747551 1.44100188373417 0.416666666666667 6.1 6 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.1092353000564 0.218317179747551 1.44100188373417 0.416666666666667 6.1 6 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.1092353000564 0.218317179747551 1.44100188373417 0.416666666666667 6.1 6 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 5.88021470029931e-12 3.98454548501234e-10 1.43761129106656 0.415686274509804 6.1 6 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00494116370434346 0.0189522262837756 1.43397260625254 0.414634146341463 6.1 6 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.21488383490115e-05 0.000105413396162459 1.4299172538593 0.413461538461538 6.1 6 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.000191086634801854 0.00123039041322642 1.4294738686643 0.413333333333333 6.1 6 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.17381008572797e-32 8.35165875995453e-30 1.42587228649138 0.412291933418694 6.1 6 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0110746512433898 0.0358164289075993 1.42404892039613 0.411764705882353 6.1 6 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0654614880112417 0.148330728407638 1.42404892039613 0.411764705882353 6.1 6 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.48735534288084e-07 2.98099528580203e-06 1.41883262398442 0.41025641025641 6.1 6 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.43102539275803e-05 0.000198813168614636 1.41794585359443 0.41 6.1 6 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0403228787818761 0.101736625011719 1.41480184948446 0.409090909090909 6.1 6 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0403228787818761 0.101736625011719 1.41480184948446 0.409090909090909 6.1 6 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00298591099192794 0.0121398609757528 1.41159368202531 0.408163265306122 6.1 6 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.00194518524320205 0.00867711160212075 1.40897961965119 0.407407407407407 6.1 6 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0252659610764524 0.0704669367383706 1.40897961965119 0.407407407407407 6.1 6 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.16201980346303e-08 2.80263420394558e-07 1.40497683664082 0.40625 6.1 6 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0160180869047589 0.0479868161378355 1.40497683664082 0.40625 6.1 6 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.000546659704605007 0.0031750888149099 1.40341053024546 0.405797101449275 6.1 6 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 8.71599325742698e-07 1.08797003555426e-05 1.40270952598459 0.405594405594406 6.1 6 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0102425322492374 0.0337184963924391 1.40205588687649 0.405405405405405 6.1 6 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 6.23892975317306e-06 5.99864664781437e-05 1.40051092171189 0.40495867768595 6.1 6 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00426514295034269 0.016501643487699 1.39807842336762 0.404255319148936 6.1 6 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 4.52290560904923e-05 0.000353631575916322 1.39733515998465 0.404040404040404 6.1 6 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00277099645991089 0.0114293564129078 1.39666336423466 0.403846153846154 6.1 6 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.72977645988441e-07 6.2901606564631e-06 1.38776741923954 0.401273885350318 6.1 6 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000718049949596686 0.00386059613972294 1.38336180838481 0.4 6.1 6 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0231418163129702 0.0649522773438987 1.38336180838481 0.4 6.1 6 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0976906570018946 0.198025363124923 1.38336180838481 0.4 6.1 6 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0976906570018946 0.198025363124923 1.38336180838481 0.4 6.1 6 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0976906570018946 0.198025363124923 1.38336180838481 0.4 6.1 6 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 7.7266541543833e-09 1.92895243187499e-07 1.38336180838481 0.4 6.1 6 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00109477612911171 0.00554400865382905 1.38336180838481 0.4 6.1 6 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00256380692460034 0.0108904395633023 1.38336180838481 0.4 6.1 6 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0367635409961061 0.0946012998869059 1.38336180838481 0.4 6.1 6 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.0367635409961061 0.0946012998869059 1.38336180838481 0.4 6.1 6 1 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.0592634685419635 0.135364230714629 1.38336180838481 0.4 6.1 6 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0592634685419635 0.135364230714629 1.38336180838481 0.4 6.1 6 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0592634685419635 0.135364230714629 1.38336180838481 0.4 6.1 6 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 8.29952775206729e-05 0.000596476161171301 1.37630383997468 0.397959183673469 6.1 6 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000437109663074533 0.00257027706840934 1.3744941044849 0.397435897435897 6.1 6 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00101248743400248 0.00525828327950922 1.37319003038198 0.397058823529412 6.1 6 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 5.16265664147161e-10 2.36982593574648e-08 1.3723827464135 0.396825396825397 6.1 6 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 5.16265664147161e-10 2.36982593574648e-08 1.3723827464135 0.396825396825397 6.1 6 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 5.16265664147161e-10 2.36982593574648e-08 1.3723827464135 0.396825396825397 6.1 6 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 5.48473398875854e-14 7.80477646600341e-12 1.36856649492615 0.39572192513369 6.1 6 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00026644098413259 0.00168509120186967 1.36727620596173 0.395348837209302 6.1 6 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000614048331370392 0.00344012116354357 1.36515967932711 0.394736842105263 6.1 6 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0134783723039035 0.0410700723521515 1.36515967932711 0.394736842105263 6.1 6 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0134783723039035 0.0410700723521515 1.36515967932711 0.394736842105263 6.1 6 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 8.86632495243173e-54 1.26167804073104e-50 1.36416085365255 0.394448030987734 6.1 6 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0211169597041207 0.0608288130748255 1.36240178098504 0.393939393939394 6.1 6 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0333843404897936 0.0868481106343259 1.35865891894936 0.392857142857143 6.1 6 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0333843404897936 0.0868481106343259 1.35865891894936 0.392857142857143 6.1 6 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.32730472338095e-17 6.62350924274219e-15 1.35541510518511 0.391919191919192 6.1 6 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0534343966025506 0.123436925917905 1.35328872559383 0.391304347826087 6.1 6 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0534343966025506 0.123436925917905 1.35328872559383 0.391304347826087 6.1 6 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.70699207662676e-08 3.91782213716109e-07 1.34924301938877 0.390134529147982 6.1 6 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.70699207662676e-08 3.91782213716109e-07 1.34924301938877 0.390134529147982 6.1 6 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00120573321422297 0.00593798317562766 1.34493509148523 0.388888888888889 6.1 6 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.00470648154643874 0.0181008736231955 1.34493509148523 0.388888888888889 6.1 6 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.019217202549566 0.0565001636942817 1.34493509148523 0.388888888888889 6.1 6 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.019217202549566 0.0565001636942817 1.34493509148523 0.388888888888889 6.1 6 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.019217202549566 0.0565001636942817 1.34493509148523 0.388888888888889 6.1 6 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0870804977033552 0.17881031490891 1.34493509148523 0.388888888888889 6.1 6 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0870804977033552 0.17881031490891 1.34493509148523 0.388888888888889 6.1 6 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 3.95951864844091e-07 5.47028644342856e-06 1.33873723392078 0.387096774193548 6.1 6 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 2.9103546102167e-05 0.000232664865749347 1.33434505139479 0.385826771653543 6.1 6 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000668366219383287 0.00363009591672678 1.33336077916608 0.385542168674699 6.1 6 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0480672459363434 0.118316770401186 1.33015558498539 0.384615384615385 6.1 6 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.146068890836507 0.266482091872243 1.33015558498539 0.384615384615385 6.1 6 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.146068890836507 0.266482091872243 1.33015558498539 0.384615384615385 6.1 6 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.146068890836507 0.266482091872243 1.33015558498539 0.384615384615385 6.1 6 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.146068890836507 0.266482091872243 1.33015558498539 0.384615384615385 6.1 6 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.146068890836507 0.266482091872243 1.33015558498539 0.384615384615385 6.1 6 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000929065702936737 0.00487586445212569 1.32358691542991 0.382716049382716 6.1 6 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.015828386918133 0.0475185539757452 1.31748743655696 0.380952380952381 6.1 6 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.015828386918133 0.0475185539757452 1.31748743655696 0.380952380952381 6.1 6 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0775374407425696 0.164998009293982 1.31748743655696 0.380952380952381 6.1 6 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.0775374407425696 0.164998009293982 1.31748743655696 0.380952380952381 6.1 6 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0775374407425696 0.164998009293982 1.31748743655696 0.380952380952381 6.1 6 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0775374407425696 0.164998009293982 1.31748743655696 0.380952380952381 6.1 6 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0775374407425696 0.164998009293982 1.31748743655696 0.380952380952381 6.1 6 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0431821533597769 0.108374257902932 1.31180861139939 0.379310344827586 6.1 6 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 8.78931791913433e-14 1.13701812717529e-11 1.31047166825691 0.378923766816143 6.1 6 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0246800453410702 0.0691332766148483 1.30858549441806 0.378378378378378 6.1 6 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00117667906588847 0.00585459549216538 1.3074456115832 0.378048780487805 6.1 6 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00842536359861703 0.0291710277392507 1.30505830979699 0.377358490566038 6.1 6 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00107352838722824 0.0054558246250921 1.30198758436217 0.376470588235294 6.1 6 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00107352838722824 0.0054558246250921 1.30198758436217 0.376470588235294 6.1 6 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.19735231114921e-08 4.96322593454813e-07 1.29855801936505 0.375478927203065 6.1 6 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0690316920503462 0.155430534474118 1.29690169536076 0.375 6.1 6 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.00453685671974642 0.017495791631976 1.29690169536076 0.375 6.1 6 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0222651778611566 0.0626153124435293 1.29690169536076 0.375 6.1 6 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.127847027604246 0.241908087256542 1.29690169536076 0.375 6.1 6 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.127847027604246 0.241908087256542 1.29690169536076 0.375 6.1 6 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.127847027604246 0.241908087256542 1.29690169536076 0.375 6.1 6 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.127847027604246 0.241908087256542 1.29690169536076 0.375 6.1 6 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.127847027604246 0.241908087256542 1.29690169536076 0.375 6.1 6 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.68158682003615e-05 0.000141591600290618 1.29411265945676 0.374193548387097 6.1 6 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.97150712452186e-14 5.28556829774325e-12 1.29338705661994 0.373983739837398 6.1 6 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0041204624646706 0.0163326409114938 1.29044944812016 0.373134328358209 6.1 6 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0041204624646706 0.0163326409114938 1.29044944812016 0.373134328358209 6.1 6 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.00692993130197257 0.0245305777181765 1.28957456713838 0.372881355932203 6.1 6 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.00692993130197257 0.0245305777181765 1.28957456713838 0.372881355932203 6.1 6 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.000100711033805038 0.000709464361903809 1.28684819384633 0.372093023255814 6.1 6 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.08643382365635e-12 3.06052385845421e-10 1.28269463453521 0.370892018779343 6.1 6 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0614797664421617 0.139977132235514 1.28089056331927 0.37037037037037 6.1 6 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0614797664421617 0.139977132235514 1.28089056331927 0.37037037037037 6.1 6 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0180932540759672 0.0537509406056395 1.2781060186164 0.369565217391304 6.1 6 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.99395687474039e-06 4.90096595362453e-05 1.27609578580951 0.368983957219251 6.1 6 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.38927680692224e-08 3.29490149375058e-07 1.27477026711228 0.368600682593857 6.1 6 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.000114095764716468 0.000791991576544068 1.27414903403864 0.368421052631579 6.1 6 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.112238276456733 0.223065736589289 1.27414903403864 0.368421052631579 6.1 6 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.112238276456733 0.223065736589289 1.27414903403864 0.368421052631579 6.1 6 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.112238276456733 0.223065736589289 1.27414903403864 0.368421052631579 6.1 6 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.62510550203601e-14 5.73169458821916e-12 1.26937694027819 0.367041198501873 6.1 6 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0547844537552965 0.125942290296909 1.26808165768607 0.366666666666667 6.1 6 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0547844537552965 0.125942290296909 1.26808165768607 0.366666666666667 6.1 6 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0988029047201087 0.199427706974063 1.25760164398619 0.363636363636364 6.1 6 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0988029047201087 0.199427706974063 1.25760164398619 0.363636363636364 6.1 6 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0988029047201087 0.199427706974063 1.25760164398619 0.363636363636364 6.1 6 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.000625340795016233 0.0034896468678749 1.25760164398619 0.363636363636364 6.1 6 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.000313529747791107 0.0019230725478739 1.25506615680073 0.362903225806452 6.1 6 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.000313529747791107 0.0019230725478739 1.25506615680073 0.362903225806452 6.1 6 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.000313529747791107 0.0019230725478739 1.25506615680073 0.362903225806452 6.1 6 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.00638489044167227 0.0227711756854628 1.25304511629059 0.36231884057971 6.1 6 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.00638489044167227 0.0227711756854628 1.25304511629059 0.36231884057971 6.1 6 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.23957098202654e-07 4.51951912492526e-06 1.25034624988627 0.361538461538462 6.1 6 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 7.24349055509081e-05 0.000531313765973929 1.24948808499273 0.361290322580645 6.1 6 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.87502455666277e-13 5.33627688010086e-11 1.24923357221062 0.361216730038023 6.1 6 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.48121222573185e-05 0.000352307458409747 1.2409569163452 0.358823529411765 6.1 6 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.0020904481551305 0.00923822274767297 1.23774477592325 0.357894736842105 6.1 6 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.0020904481551305 0.00923822274767297 1.23774477592325 0.357894736842105 6.1 6 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.0020904481551305 0.00923822274767297 1.23774477592325 0.357894736842105 6.1 6 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.00103780981382671 0.00535073682998335 1.23741079190384 0.357798165137615 6.1 6 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00785410701875695 0.0275075404358001 1.23514447177215 0.357142857142857 6.1 6 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0347753593442119 0.0899733388123881 1.23514447177215 0.357142857142857 6.1 6 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0347753593442119 0.0899733388123881 1.23514447177215 0.357142857142857 6.1 6 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0770883364156993 0.164998009293982 1.23514447177215 0.357142857142857 6.1 6 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.187342802430188 0.327962771494912 1.23514447177215 0.357142857142857 6.1 6 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.187342802430188 0.327962771494912 1.23514447177215 0.357142857142857 6.1 6 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.187342802430188 0.327962771494912 1.23514447177215 0.357142857142857 6.1 6 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 8.87594425647018e-05 0.000634696918440053 1.23059792770428 0.355828220858896 6.1 6 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 7.30154931749213e-05 0.000532825880963656 1.2278359246019 0.355029585798817 6.1 6 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00282280848098561 0.0115820279190059 1.22717579776072 0.354838709677419 6.1 6 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0682865820612175 0.153996523412223 1.22717579776072 0.354838709677419 6.1 6 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.0682865820612175 0.153996523412223 1.22717579776072 0.354838709677419 6.1 6 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 7.14378540073542e-06 6.68789909555691e-05 1.22616160288653 0.354545454545455 6.1 6 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00126437730303245 0.00593798317562766 1.22616160288653 0.354545454545455 6.1 6 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.0001309666981698 0.000883249343581164 1.22576362768274 0.354430379746835 6.1 6 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.0278152237988598 0.0759713310283637 1.22485160117405 0.354166666666667 6.1 6 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.161875503745884 0.290111891474047 1.22061336033954 0.352941176470588 6.1 6 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.161875503745884 0.290111891474047 1.22061336033954 0.352941176470588 6.1 6 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.161875503745884 0.290111891474047 1.22061336033954 0.352941176470588 6.1 6 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.161875503745884 0.290111891474047 1.22061336033954 0.352941176470588 6.1 6 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0042141306383318 0.0164744722482037 1.21830159261162 0.352272727272727 6.1 6 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.0042141306383318 0.0164744722482037 1.21830159261162 0.352272727272727 6.1 6 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.00169696183520714 0.00771494150638901 1.2168460351533 0.351851851851852 6.1 6 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.20038273743137e-20 7.82786158841212e-18 1.21165323557228 0.35035035035035 6.1 6 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0478885558615285 0.118308012137075 1.21044158233671 0.35 6.1 6 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0478885558615285 0.118308012137075 1.21044158233671 0.35 6.1 6 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.140763173026224 0.259128066256554 1.21044158233671 0.35 6.1 6 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.140763173026224 0.259128066256554 1.21044158233671 0.35 6.1 6 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.140763173026224 0.259128066256554 1.21044158233671 0.35 6.1 6 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 7.18295088544044e-05 0.000529603062693355 1.20949666306868 0.349726775956284 6.1 6 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.00566324404738404 0.021041243549419 1.20642018173094 0.348837209302326 6.1 6 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0380242251506017 0.0964500399096367 1.20292331163896 0.347826086956522 6.1 6 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.107890617002952 0.216847949145763 1.19714002648685 0.346153846153846 6.1 6 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0270853278971012 0.0744062193003378 1.19472156178688 0.345454545454545 6.1 6 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00682212515739991 0.0242697102474502 1.19255328309035 0.344827586206897 6.1 6 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0949336959188161 0.19353961216687 1.19255328309035 0.344827586206897 6.1 6 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0949336959188161 0.19353961216687 1.19255328309035 0.344827586206897 6.1 6 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00613801326021324 0.0224655876012239 1.19122822388692 0.344444444444444 6.1 6 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0837500818679337 0.172469416060882 1.18882655408069 0.34375 6.1 6 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0740466037542253 0.164637995534785 1.18573869290126 0.342857142857143 6.1 6 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.00265798054804923 0.0111572457813394 1.18313838875016 0.342105263157895 6.1 6 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0655911526767147 0.148388251604078 1.18313838875016 0.342105263157895 6.1 6 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.0409768543607747 0.103203652664394 1.17585753712709 0.34 6.1 6 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 3.87092762683122e-05 0.00030601833405449 1.17259209079828 0.339055793991416 6.1 6 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.00546892986295324 0.0205337393007453 1.15280150698734 0.333333333333333 6.1 6 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.0115296308036408 0.0360586035902876 1.15280150698734 0.333333333333333 6.1 6 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.012843873215473 0.0399057458201267 1.15280150698734 0.333333333333333 6.1 6 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.012843873215473 0.0399057458201267 1.15280150698734 0.333333333333333 6.1 6 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0620196253954984 0.140980713958138 1.15280150698734 0.333333333333333 6.1 6 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0892756265973067 0.18252761012639 1.15280150698734 0.333333333333333 6.1 6 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.115008317000576 0.228252210727782 1.15280150698734 0.333333333333333 6.1 6 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.149983317549036 0.271189658033391 1.15280150698734 0.333333333333333 6.1 6 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.149983317549036 0.271189658033391 1.15280150698734 0.333333333333333 6.1 6 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.149983317549036 0.271189658033391 1.15280150698734 0.333333333333333 6.1 6 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.149983317549036 0.271189658033391 1.15280150698734 0.333333333333333 6.1 6 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.149983317549036 0.271189658033391 1.15280150698734 0.333333333333333 6.1 6 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.199273006767149 0.339193168217288 1.15280150698734 0.333333333333333 6.1 6 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.199273006767149 0.339193168217288 1.15280150698734 0.333333333333333 6.1 6 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.232168875144335 0.371626894634858 1.15280150698734 0.333333333333333 6.1 6 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.232168875144335 0.371626894634858 1.15280150698734 0.333333333333333 6.1 6 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.232168875144335 0.371626894634858 1.15280150698734 0.333333333333333 6.1 6 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.232168875144335 0.371626894634858 1.15280150698734 0.333333333333333 6.1 6 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.000562023778793833 0.00325105624887652 1.15280150698734 0.333333333333333 6.1 6 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.101200046522196 0.203688353891209 1.15280150698734 0.333333333333333 6.1 6 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.131096042283346 0.24258734482341 1.15280150698734 0.333333333333333 6.1 6 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00984273561144075 0.0326485146272265 1.14127349191747 0.33 6.1 6 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0653648816423284 0.148330728407638 1.12927494562025 0.326530612244898 6.1 6 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0736303029333517 0.163968577580844 1.12774060466153 0.326086956521739 6.1 6 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0830658081633976 0.171308181183355 1.12599216961554 0.325581395348837 6.1 6 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.00103635939574033 0.00535073682998335 1.11677645989399 0.322916666666667 6.1 6 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.179536630739945 0.31618889299869 1.10668944670785 0.32 6.1 6 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.179536630739945 0.31618889299869 1.10668944670785 0.32 6.1 6 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.179536630739945 0.31618889299869 1.10668944670785 0.32 6.1 6 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.0448659221798974 0.112007381161393 1.10267970233572 0.318840579710145 6.1 6 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.20671016857709 0.351431983136439 1.10040143848792 0.318181818181818 6.1 6 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.0372438114016265 0.09537622028805 1.09443181043102 0.316455696202532 6.1 6 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.0187279881065278 0.0555206814074771 1.08875697882138 0.314814814814815 6.1 6 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.141971893979177 0.261015510506937 1.08692713515949 0.314285714285714 6.1 6 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.0345207497384987 0.0896405599961382 1.08577816355784 0.313953488372093 6.1 6 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 3.76253084536362e-10 1.91217192605444e-08 1.08368557953222 0.313348416289593 6.1 6 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.100887853017695 0.203347613093739 1.08075141280063 0.3125 6.1 6 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.161577980547004 0.290111891474047 1.08075141280063 0.3125 6.1 6 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.279587896753467 0.431043962167046 1.08075141280063 0.3125 6.1 6 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.279587896753467 0.431043962167046 1.08075141280063 0.3125 6.1 6 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.0730796744642028 0.16299745574069 1.07720796554555 0.311475409836066 6.1 6 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 0.0025979306371329 0.0109913840900997 1.07045854220253 0.30952380952381 6.1 6 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00507396531495506 0.0193243547689623 1.06556247402614 0.308108108108108 6.1 6 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.145582425829601 0.266482091872243 1.06412446798831 0.307692307692308 6.1 6 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.211379303511942 0.357649688527603 1.06412446798831 0.307692307692308 6.1 6 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.0189205932300699 0.0559750606369844 1.06202973478361 0.307086614173228 6.1 6 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 7.18937324612852e-07 9.13435547253651e-06 1.05957339133673 0.306376360808709 6.1 6 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.0563163109656327 0.129255016942089 1.05439162224452 0.304878048780488 6.1 6 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.24333361128709 0.386455054532956 1.05255789768409 0.304347826086957 6.1 6 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.0352187040924263 0.0909550198249049 1.04703990084171 0.302752293577982 6.1 6 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.0292025676637092 0.0794555521710482 1.04624002314817 0.302521008403361 6.1 6 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.0106404909209879 0.0344907029170064 1.04556415750015 0.302325581395349 6.1 6 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.148332498739117 0.26991962366466 1.04556415750015 0.302325581395349 6.1 6 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.214230527779687 0.357649688527603 1.03752135628861 0.3 6.1 6 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.214230527779687 0.357649688527603 1.03752135628861 0.3 6.1 6 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.167744569229985 0.296891196535161 1.03752135628861 0.3 6.1 6 1 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.281734186267379 0.433003790278919 1.03752135628861 0.3 6.1 6 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.281734186267379 0.433003790278919 1.03752135628861 0.3 6.1 6 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.0885874339661204 0.18138117774646 1.02817431704276 0.297297297297297 6.1 6 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.0885874339661204 0.18138117774646 1.02817431704276 0.297297297297297 6.1 6 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0415315778246695 0.104415963329514 1.0205128094642 0.295081967213115 6.1 6 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.0502255850127715 0.118316770401186 1.01899418921202 0.294642857142857 6.1 6 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.21583146895463 0.357649688527603 1.01717780028295 0.294117647058824 6.1 6 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.328634727173292 0.485111220713273 1.01717780028295 0.294117647058824 6.1 6 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.328634727173292 0.485111220713273 1.01717780028295 0.294117647058824 6.1 6 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.328634727173292 0.485111220713273 1.01717780028295 0.294117647058824 6.1 6 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.191459404166458 0.327962771494912 1.01221595735474 0.292682926829268 6.1 6 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.191459404166458 0.327962771494912 1.01221595735474 0.292682926829268 6.1 6 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.191459404166458 0.327962771494912 1.01221595735474 0.292682926829268 6.1 6 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.191459404166458 0.327962771494912 1.01221595735474 0.292682926829268 6.1 6 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.191459404166458 0.327962771494912 1.01221595735474 0.292682926829268 6.1 6 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.191459404166458 0.327962771494912 1.01221595735474 0.292682926829268 6.1 6 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.191459404166458 0.327962771494912 1.01221595735474 0.292682926829268 6.1 6 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.281771967532171 0.433003790278919 1.00870131861392 0.291666666666667 6.1 6 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.111997025822394 0.223065736589289 1.00111709817322 0.289473684210526 6.1 6 1 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.216602882407016 0.357649688527603 0.98811557741772 0.285714285714286 6.1 6 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.245375298944811 0.388019075415029 0.98811557741772 0.285714285714286 6.1 6 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.325477445107111 0.485107832138273 0.98811557741772 0.285714285714286 6.1 6 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.216178319323456 0.357649688527603 0.977375190706658 0.282608695652174 6.1 6 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.244419518370009 0.387315116526194 0.975447428989287 0.282051282051282 6.1 6 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.244419518370009 0.387315116526194 0.975447428989287 0.282051282051282 6.1 6 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.154243307808155 0.278538359151021 0.974198456609019 0.28169014084507 6.1 6 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0536327931828786 0.123694432251598 0.970040292464956 0.280487804878049 6.1 6 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.321530154062481 0.480606522301376 0.968353265869365 0.28 6.1 6 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.321530154062481 0.480606522301376 0.968353265869365 0.28 6.1 6 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.321530154062481 0.480606522301376 0.968353265869365 0.28 6.1 6 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.191262430905249 0.327962771494912 0.963817653382858 0.278688524590164 6.1 6 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.191262430905249 0.327962771494912 0.963817653382858 0.278688524590164 6.1 6 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.191262430905249 0.327962771494912 0.963817653382858 0.278688524590164 6.1 6 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.191262430905249 0.327962771494912 0.963817653382858 0.278688524590164 6.1 6 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.138222149440485 0.255441712537415 0.96066792248945 0.277777777777778 6.1 6 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.170783193451308 0.30189376929343 0.96066792248945 0.277777777777778 6.1 6 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.37838923502181 0.548317598203702 0.96066792248945 0.277777777777778 6.1 6 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.37838923502181 0.548317598203702 0.96066792248945 0.277777777777778 6.1 6 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.241328334683047 0.383698570116174 0.956579973883111 0.276595744680851 6.1 6 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.213021471051557 0.357649688527603 0.954042626472281 0.275862068965517 6.1 6 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.239399319618802 0.381057306283619 0.94936594693075 0.274509803921569 6.1 6 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.0285912365519 0.0779412444700263 0.948876330661059 0.274368231046931 6.1 6 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.370015173805868 0.538375861273774 0.943201232989642 0.272727272727273 6.1 6 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.370015173805868 0.538375861273774 0.943201232989642 0.272727272727273 6.1 6 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.370015173805868 0.538375861273774 0.943201232989642 0.272727272727273 6.1 6 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.312700702542792 0.469478514026509 0.943201232989641 0.272727272727273 6.1 6 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.148331859756432 0.26991962366466 0.937324589793444 0.271028037383178 6.1 6 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0464392975391194 0.115732259891711 0.935803576260311 0.270588235294118 6.1 6 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.30814046249347 0.469478514026509 0.934703924584329 0.27027027027027 6.1 6 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.232785811708825 0.371778013537214 0.93322026756118 0.26984126984127 6.1 6 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.232785811708825 0.371778013537214 0.93322026756118 0.26984126984127 6.1 6 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.264401116419092 0.411644188910687 0.931108909489774 0.269230769230769 6.1 6 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.264401116419092 0.411644188910687 0.931108909489774 0.269230769230769 6.1 6 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.362112046370575 0.529040494851466 0.931108909489774 0.269230769230769 6.1 6 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.303585815488495 0.46542919352497 0.927864627575176 0.268292682926829 6.1 6 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.0390851880677902 0.0989648089332127 0.922948445778207 0.266871165644172 6.1 6 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.354645899513272 0.518665071950038 0.922241205589872 0.266666666666667 6.1 6 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.34757362663453 0.508844928704667 0.915460020254652 0.264705882352941 6.1 6 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.24853163404723 0.392519994727201 0.912634526364977 0.263888888888889 6.1 6 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.245409113052373 0.388019075415029 0.910106452884742 0.263157894736842 6.1 6 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.42801293242423 0.589605423852545 0.910106452884742 0.263157894736842 6.1 6 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.161784187393453 0.290111891474047 0.907524590607055 0.26241134751773 6.1 6 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.239269839358881 0.381057306283619 0.90577261263291 0.261904761904762 6.1 6 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.239269839358881 0.381057306283619 0.90577261263291 0.261904761904762 6.1 6 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0951015894482326 0.193604523297332 0.9027963608937 0.261044176706827 6.1 6 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.414726313518379 0.572410809055919 0.902192483729222 0.260869565217391 6.1 6 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.269754058342786 0.419519153029273 0.90013268353806 0.26027397260274 6.1 6 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.403037288926882 0.558935579776645 0.896623394323486 0.259259259259259 6.1 6 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.403037288926882 0.558935579776645 0.896623394323486 0.259259259259259 6.1 6 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.311431861215836 0.469478514026509 0.894414962317763 0.258620689655172 6.1 6 1 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.392533240035167 0.557289381944007 0.892491489280521 0.258064516129032 6.1 6 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.344004338087484 0.504138180328002 0.880321150790332 0.254545454545455 6.1 6 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.344004338087484 0.504138180328002 0.880321150790332 0.254545454545455 6.1 6 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.344004338087484 0.504138180328002 0.880321150790332 0.254545454545455 6.1 6 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.325240553797512 0.485107832138273 0.877505624721706 0.253731343283582 6.1 6 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.284760684904729 0.437124546515026 0.873334474990409 0.252525252525253 6.1 6 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.363929151439981 0.531149930768301 0.864601130240505 0.25 6.1 6 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.303853633720799 0.46542919352497 0.864601130240505 0.25 6.1 6 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.343172854868357 0.504138180328002 0.864601130240505 0.25 6.1 6 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.371595288619273 0.540122671813305 0.864601130240505 0.25 6.1 6 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.388373084719655 0.557289381944007 0.864601130240505 0.25 6.1 6 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.388373084719655 0.557289381944007 0.864601130240505 0.25 6.1 6 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.388373084719655 0.557289381944007 0.864601130240505 0.25 6.1 6 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.443854905644598 0.610246889596389 0.864601130240505 0.25 6.1 6 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.476772514476514 0.643077998199127 0.864601130240505 0.25 6.1 6 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00359386305121143 0.0144874422715974 0.860383563751527 0.248780487804878 6.1 6 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.37463303306654 0.543982455156823 0.852070679077599 0.246376811594203 6.1 6 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.408793944590771 0.564770663255017 0.848287901368042 0.245283018867925 6.1 6 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.399753620423583 0.558791160965382 0.839898240805062 0.242857142857143 6.1 6 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.468190542089313 0.633303366343243 0.838401095990792 0.242424242424242 6.1 6 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.468190542089313 0.633303366343243 0.838401095990792 0.242424242424242 6.1 6 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.437948691454255 0.602708885821474 0.832578866157523 0.240740740740741 6.1 6 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.425014698255594 0.586042553893131 0.828068688117666 0.23943661971831 6.1 6 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.461337620937465 0.629662856599002 0.827009776751787 0.239130434782609 6.1 6 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.341147345680906 0.5020193101385 0.825101586219365 0.238578680203046 6.1 6 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.524052223654451 0.688588610904027 0.8234296478481 0.238095238095238 6.1 6 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.524052223654451 0.688588610904027 0.8234296478481 0.238095238095238 6.1 6 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.467026705591588 0.632932382911266 0.817441068591023 0.236363636363636 6.1 6 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.467026705591588 0.632932382911266 0.817441068591023 0.236363636363636 6.1 6 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.467026705591588 0.632932382911266 0.817441068591023 0.236363636363636 6.1 6 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.455089876451728 0.625089666207345 0.811230690102202 0.234567901234568 6.1 6 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.47165257288086 0.636775722210118 0.810563559600473 0.234375 6.1 6 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.47165257288086 0.636775722210118 0.810563559600473 0.234375 6.1 6 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.50934882517058 0.675492430771422 0.798093350991235 0.230769230769231 6.1 6 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.544577372185873 0.700663291700269 0.798093350991235 0.230769230769231 6.1 6 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.463856846359975 0.630437719551332 0.794788616618601 0.229813664596273 6.1 6 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.510950611272647 0.676985772663852 0.793732185138824 0.229508196721311 6.1 6 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.541556318653804 0.697406915334266 0.790492461934176 0.228571428571429 6.1 6 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.480777118102554 0.647865377897666 0.789882514046881 0.228395061728395 6.1 6 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.491669348793694 0.656327845528542 0.786001027491368 0.227272727272727 6.1 6 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.538779521925646 0.694459474366118 0.783034985878193 0.226415094339623 6.1 6 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.53815413361979 0.694282259420636 0.780930053120456 0.225806451612903 6.1 6 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.561787781970685 0.720851229706298 0.780930053120456 0.225806451612903 6.1 6 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.561787781970685 0.720851229706298 0.780930053120456 0.225806451612903 6.1 6 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.567588330631758 0.723725980724903 0.76853433799156 0.222222222222222 6.1 6 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.571332751733493 0.727848259370422 0.76853433799156 0.222222222222222 6.1 6 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.576708421708445 0.734039431208513 0.76853433799156 0.222222222222222 6.1 6 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.585017395974156 0.739982003974422 0.76853433799156 0.222222222222222 6.1 6 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.579723770865051 0.737217985648765 0.762021335127224 0.220338983050847 6.1 6 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.581171047451066 0.737739875577937 0.761284014048243 0.220125786163522 6.1 6 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.581171047451066 0.737739875577937 0.761284014048243 0.220125786163522 6.1 6 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.588895620467167 0.744225992828401 0.759161968016053 0.219512195121951 6.1 6 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.595652039945294 0.752096586372806 0.754560986391713 0.218181818181818 6.1 6 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.60188695473239 0.758622795911596 0.751827069774352 0.217391304347826 6.1 6 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.61231027298175 0.769035762094466 0.751827069774352 0.217391304347826 6.1 6 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.61231027298175 0.769035762094466 0.751827069774352 0.217391304347826 6.1 6 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.61231027298175 0.769035762094466 0.751827069774352 0.217391304347826 6.1 6 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.606378874007094 0.763608086470881 0.749320979541771 0.216666666666667 6.1 6 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.62041053739517 0.776009333038891 0.744213631093093 0.215189873417722 6.1 6 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.645393739210294 0.782280789934623 0.742602197752581 0.214723926380368 6.1 6 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.623516256973127 0.776009333038891 0.74108668306329 0.214285714285714 6.1 6 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.647491859671672 0.783487173735364 0.739200966312493 0.213740458015267 6.1 6 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.647491859671672 0.783487173735364 0.739200966312493 0.213740458015267 6.1 6 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.66376124880258 0.799096664167573 0.73630547865643 0.212903225806452 6.1 6 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.640984968395798 0.778260759408891 0.733600958991943 0.212121212121212 6.1 6 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.659837614590349 0.795086763641678 0.731585571741965 0.211538461538462 6.1 6 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.729350493696969 0.847724462512341 0.728735238345568 0.210714285714286 6.1 6 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.659622354614943 0.795086763641678 0.720500941867087 0.208333333333333 6.1 6 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.659622354614943 0.795086763641678 0.720500941867087 0.208333333333333 6.1 6 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.667205839336111 0.802564589497283 0.717782070388344 0.207547169811321 6.1 6 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.659871727238807 0.795086763641678 0.715531969854211 0.206896551724138 6.1 6 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.674376941700882 0.809138607116657 0.715531969854211 0.206896551724138 6.1 6 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.674376941700882 0.809138607116657 0.715531969854211 0.206896551724138 6.1 6 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.674376941700882 0.809138607116657 0.715531969854211 0.206896551724138 6.1 6 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.714194529107535 0.840902150979933 0.711073826739854 0.205607476635514 6.1 6 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.686610935636169 0.81846744404879 0.705796841012657 0.204081632653061 6.1 6 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.686610935636169 0.81846744404879 0.705796841012657 0.204081632653061 6.1 6 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.730620563275817 0.847724462512341 0.691680904192404 0.2 6.1 6 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.690186739997752 0.81846744404879 0.691680904192404 0.2 6.1 6 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.690186739997752 0.81846744404879 0.691680904192404 0.2 6.1 6 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.690186739997752 0.81846744404879 0.691680904192404 0.2 6.1 6 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.690186739997752 0.81846744404879 0.691680904192404 0.2 6.1 6 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.902607695596293 0.990691527101273 0.686332855964112 0.198453608247423 6.1 6 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.808621591111256 0.914680861805498 0.681938919626314 0.197183098591549 6.1 6 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.806011296820906 0.913143619690344 0.68158337274434 0.197080291970803 6.1 6 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.72566571507176 0.846826650156398 0.669368616960391 0.193548387096774 6.1 6 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.880464135990829 0.975756464959445 0.669368616960391 0.193548387096774 6.1 6 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.840239271445182 0.945050402764054 0.666978014756961 0.192857142857143 6.1 6 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.724855637095819 0.846826650156398 0.665077792492696 0.192307692307692 6.1 6 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.849104892977899 0.953651351781808 0.661165570183915 0.191176470588235 6.1 6 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.783705834684944 0.893600482978106 0.65874371827848 0.19047619047619 6.1 6 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.859198888474132 0.957431494360759 0.656339544124179 0.18978102189781 6.1 6 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.779639196874921 0.892561795487619 0.643424096923166 0.186046511627907 6.1 6 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.781967816777894 0.892561795487619 0.628800821993094 0.181818181818182 6.1 6 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.781967816777894 0.892561795487619 0.628800821993094 0.181818181818182 6.1 6 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.820376872583512 0.926504991814553 0.622512813773163 0.18 6.1 6 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.785576359567219 0.894797494026038 0.617572235886075 0.178571428571429 6.1 6 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.806620892446073 0.913143619690344 0.610306680169768 0.176470588235294 6.1 6 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.902970422101441 0.990691527101273 0.606112132539735 0.175257731958763 6.1 6 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.840782719535694 0.945050402764054 0.601461655819482 0.173913043478261 6.1 6 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.896425941978411 0.988664594420713 0.597748929548991 0.172839506172839 6.1 6 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.856417268744744 0.957330536860778 0.557807180800326 0.161290322580645 6.1 6 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.883990849115345 0.977404023536236 0.546063871730845 0.157894736842105 6.1 6 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.918272371663701 1 0.546063871730845 0.157894736842105 6.1 6 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.919457283219135 1 0.49405778870886 0.142857142857143 6.1 6 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999999937 1 0.487835398422854 0.141057934508816 6.1 6 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.972936637820581 1 0.432300565120252 0.125 6.1 6 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.403376295844575 0.116636528028933 6.1 6 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0334684308480195 0.00967741935483871 6.1 6 1 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.00124670110503289 0.00552665318523927 2.80868979454362 1 7.1 7 1 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.00124670110503289 0.00552665318523927 2.80868979454362 1 7.1 7 1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00124670110503289 0.00552665318523927 2.80868979454362 1 7.1 7 1 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00124670110503289 0.00552665318523927 2.80868979454362 1 7.1 7 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 2.25313925927519e-05 0.00016731639728828 2.80868979454362 1 7.1 7 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 3.70870735014051e-06 3.34018389825946e-05 2.57463231166498 0.916666666666667 7.1 7 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 1.07815607181121e-09 2.36033244644207e-08 2.54119552839661 0.904761904761905 7.1 7 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 4.38489524245953e-08 6.22187692274588e-07 2.49661315070544 0.888888888888889 7.1 7 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000155487601695918 0.000953701970746944 2.49661315070544 0.888888888888889 7.1 7 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.00052919912157511 0.00268946553571922 2.45760357022567 0.875 7.1 7 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00052919912157511 0.00268946553571922 2.45760357022567 0.875 7.1 7 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00177517709255532 0.00754052836628721 2.4074483953231 0.857142857142857 7.1 7 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 1.83226429341185e-05 0.000141701743995927 2.37658367230614 0.846153846153846 7.1 7 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 5.94115041944545e-05 0.000404509906548846 2.34057482878635 0.833333333333333 7.1 7 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00584423074101978 0.0210540261885346 2.34057482878635 0.833333333333333 7.1 7 1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00584423074101978 0.0210540261885346 2.34057482878635 0.833333333333333 7.1 7 1 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00584423074101978 0.0210540261885346 2.34057482878635 0.833333333333333 7.1 7 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.00584423074101978 0.0210540261885346 2.34057482878635 0.833333333333333 7.1 7 1 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.00584423074101978 0.0210540261885346 2.34057482878635 0.833333333333333 7.1 7 1 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605647 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS 0.00584423074101978 0.0210540261885346 2.34057482878635 0.833333333333333 7.1 7 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 9.96225993810046e-10 2.21504623311202e-08 2.30713804551797 0.821428571428571 7.1 7 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 8.11990722279848e-08 1.00475025896019e-06 2.29801892280841 0.818181818181818 7.1 7 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000189909505904625 0.0010985415727735 2.29801892280841 0.818181818181818 7.1 7 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 2.49570750924697e-15 1.77569589282922e-13 2.28206045806669 0.8125 7.1 7 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 6.79742878728155e-06 5.93419703331389e-05 2.28206045806669 0.8125 7.1 7 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 6.79742878728155e-06 5.93419703331389e-05 2.28206045806669 0.8125 7.1 7 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 7.89240531537393e-07 8.42198435552869e-06 2.24695183563489 0.8 7.1 7 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.000596801072760687 0.00290838331006321 2.24695183563489 0.8 7.1 7 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000596801072760687 0.00290838331006321 2.24695183563489 0.8 7.1 7 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 6.50368731468492e-05 0.000428460511518363 2.20682769571284 0.785714285714286 7.1 7 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00183718944115228 0.00778071599630862 2.18453650686726 0.777777777777778 7.1 7 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.000196374375062241 0.00112677716013536 2.1605306111874 0.769230769230769 7.1 7 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000196374375062241 0.00112677716013536 2.1605306111874 0.769230769230769 7.1 7 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.15977708898165e-08 2.03748493533443e-07 2.15332884248344 0.766666666666667 7.1 7 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.90297760250474e-07 3.38601403964283e-06 2.13460424385315 0.76 7.1 7 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.91912999813555e-12 3.18442871291059e-10 2.12212117809962 0.755555555555556 7.1 7 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.39433699463401e-09 2.87556745415101e-08 2.10651734590771 0.75 7.1 7 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 6.43268095222206e-05 0.000425753720698232 2.10651734590771 0.75 7.1 7 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 6.43268095222206e-05 0.000425753720698232 2.10651734590771 0.75 7.1 7 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000581403511035135 0.00287269859792707 2.10651734590771 0.75 7.1 7 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.000581403511035135 0.00287269859792707 2.10651734590771 0.75 7.1 7 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.000581403511035135 0.00287269859792707 2.10651734590771 0.75 7.1 7 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.000581403511035135 0.00287269859792707 2.10651734590771 0.75 7.1 7 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00551311100549595 0.020167498613935 2.10651734590771 0.75 7.1 7 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00551311100549595 0.020167498613935 2.10651734590771 0.75 7.1 7 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 6.93726564302378e-12 3.18442871291059e-10 2.09157750657503 0.74468085106383 7.1 7 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 2.10784736718648e-05 0.000161261656102492 2.06956090124267 0.736842105263158 7.1 7 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.000185643895880389 0.00107825005648079 2.05970584933199 0.733333333333333 7.1 7 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 8.11118732565348e-07 8.42497778423716e-06 2.05250408062803 0.730769230769231 7.1 7 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00168184525104352 0.00723041024844389 2.04268348694081 0.727272727272727 7.1 7 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 5.97409641540054e-05 0.000404816152338808 2.02849818494817 0.722222222222222 7.1 7 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 8.98830301022472e-08 1.10261682616808e-06 2.01874578982823 0.71875 7.1 7 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 7.50619318150627e-07 8.28008751727397e-06 2.00620699610258 0.714285714285714 7.1 7 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000524718129850721 0.00268587733373229 2.00620699610258 0.714285714285714 7.1 7 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.000524718129850721 0.00268587733373229 2.00620699610258 0.714285714285714 7.1 7 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000524718129850721 0.00268587733373229 2.00620699610258 0.714285714285714 7.1 7 1 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0160168648621809 0.0473846126795913 2.00620699610258 0.714285714285714 7.1 7 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0160168648621809 0.0473846126795913 2.00620699610258 0.714285714285714 7.1 7 1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0160168648621809 0.0473846126795913 2.00620699610258 0.714285714285714 7.1 7 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0160168648621809 0.0473846126795913 2.00620699610258 0.714285714285714 7.1 7 1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0160168648621809 0.0473846126795913 2.00620699610258 0.714285714285714 7.1 7 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0160168648621809 0.0473846126795913 2.00620699610258 0.714285714285714 7.1 7 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000166177634129253 0.000985294889024696 1.98260456085432 0.705882352941177 7.1 7 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000166177634129253 0.000985294889024696 1.98260456085432 0.705882352941177 7.1 7 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.0599720773699e-06 1.92851333295879e-05 1.97648541097514 0.703703703703704 7.1 7 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00473142896739933 0.0176017354899988 1.96608285618053 0.7 7.1 7 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00473142896739933 0.0176017354899988 1.96608285618053 0.7 7.1 7 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00473142896739933 0.0176017354899988 1.96608285618053 0.7 7.1 7 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.00473142896739933 0.0176017354899988 1.96608285618053 0.7 7.1 7 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.00473142896739933 0.0176017354899988 1.96608285618053 0.7 7.1 7 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00144771906697415 0.00630001294282634 1.94447755006866 0.692307692307692 7.1 7 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.81875834822412e-06 1.72539541968195e-05 1.93702744451284 0.689655172413793 7.1 7 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000452541485868361 0.00235885177432483 1.93097423374874 0.6875 7.1 7 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000452541485868361 0.00235885177432483 1.93097423374874 0.6875 7.1 7 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000143509693531977 0.000884044562320358 1.92173512258248 0.684210526315789 7.1 7 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 4.59829179779146e-05 0.000325540757624738 1.91501576900701 0.681818181818182 7.1 7 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 1.48488577963521e-05 0.000116098487056094 1.90990906028966 0.68 7.1 7 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.58524701068854e-08 2.62303080954626e-07 1.87245986302908 0.666666666666667 7.1 7 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 4.79159957507135e-08 6.25545522507022e-07 1.87245986302908 0.666666666666667 7.1 7 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00037905097407975 0.00202778021096046 1.87245986302908 0.666666666666667 7.1 7 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00037905097407975 0.00202778021096046 1.87245986302908 0.666666666666667 7.1 7 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00037905097407975 0.00202778021096046 1.87245986302908 0.666666666666667 7.1 7 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00037905097407975 0.00202778021096046 1.87245986302908 0.666666666666667 7.1 7 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00120286659779139 0.00539961882857142 1.87245986302908 0.666666666666667 7.1 7 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00120286659779139 0.00539961882857142 1.87245986302908 0.666666666666667 7.1 7 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00388272873106029 0.0150959644379748 1.87245986302908 0.666666666666667 7.1 7 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0128649541341833 0.0398841606382196 1.87245986302908 0.666666666666667 7.1 7 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0128649541341833 0.0398841606382196 1.87245986302908 0.666666666666667 7.1 7 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0128649541341833 0.0398841606382196 1.87245986302908 0.666666666666667 7.1 7 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0128649541341833 0.0398841606382196 1.87245986302908 0.666666666666667 7.1 7 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 4.94022734748352e-10 1.13450796605979e-08 1.85574147139489 0.660714285714286 7.1 7 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 4.05980652685349e-08 6.01781738303388e-07 1.85118191004011 0.659090909090909 7.1 7 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.65335684805213e-11 1.32434535895564e-09 1.84320267766925 0.65625 7.1 7 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 3.23688030663971e-05 0.000237426838987026 1.83645101950929 0.653846153846154 7.1 7 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.31152483709995e-11 3.97085073019837e-10 1.83175421383279 0.652173913043478 7.1 7 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000100016046421086 0.000635369794898235 1.83175421383279 0.652173913043478 7.1 7 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.000100016046421086 0.000635369794898235 1.83175421383279 0.652173913043478 7.1 7 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00031123739538369 0.00169689966908426 1.82564836645335 0.65 7.1 7 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00031123739538369 0.00169689966908426 1.82564836645335 0.65 7.1 7 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 9.4118409752703e-07 9.70510848392002e-06 1.82185283970397 0.648648648648649 7.1 7 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.00097754188072339 0.00450175435685885 1.81738751411646 0.647058823529412 7.1 7 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00097754188072339 0.00450175435685885 1.81738751411646 0.647058823529412 7.1 7 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00097754188072339 0.00450175435685885 1.81738751411646 0.647058823529412 7.1 7 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00097754188072339 0.00450175435685885 1.81738751411646 0.647058823529412 7.1 7 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00310912075379631 0.0122896634240337 1.80558629649233 0.642857142857143 7.1 7 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00310912075379631 0.0122896634240337 1.80558629649233 0.642857142857143 7.1 7 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00310912075379631 0.0122896634240337 1.80558629649233 0.642857142857143 7.1 7 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 8.16477133479497e-05 0.00052572260676078 1.79756146850791 0.64 7.1 7 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 8.16477133479497e-05 0.00052572260676078 1.79756146850791 0.64 7.1 7 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000251968650630605 0.00142282297558473 1.78734805107321 0.636363636363636 7.1 7 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000251968650630605 0.00142282297558473 1.78734805107321 0.636363636363636 7.1 7 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.010068200471022 0.0325614756142371 1.78734805107321 0.636363636363636 7.1 7 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.010068200471022 0.0325614756142371 1.78734805107321 0.636363636363636 7.1 7 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.010068200471022 0.0325614756142371 1.78734805107321 0.636363636363636 7.1 7 1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.010068200471022 0.0325614756142371 1.78734805107321 0.636363636363636 7.1 7 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 5.78262474214341e-08 7.41322072799106e-07 1.776926196548 0.63265306122449 7.1 7 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.9169999541137e-06 1.80655028788331e-05 1.77390934392228 0.631578947368421 7.1 7 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.45962817227565e-09 2.96721555592607e-08 1.76675648366453 0.629032258064516 7.1 7 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 5.78144452568416e-06 5.14187222503035e-05 1.76546215657027 0.628571428571429 7.1 7 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.55401067866783e-06 1.50432462295532e-05 1.75543112158976 0.625 7.1 7 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00245340845099642 0.00997485778790832 1.75543112158976 0.625 7.1 7 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00245340845099642 0.00997485778790832 1.75543112158976 0.625 7.1 7 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00245340845099642 0.00997485778790832 1.75543112158976 0.625 7.1 7 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00245340845099642 0.00997485778790832 1.75543112158976 0.625 7.1 7 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0335231212899892 0.0848814975011648 1.75543112158976 0.625 7.1 7 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0335231212899892 0.0848814975011648 1.75543112158976 0.625 7.1 7 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0335231212899892 0.0848814975011648 1.75543112158976 0.625 7.1 7 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0335231212899892 0.0848814975011648 1.75543112158976 0.625 7.1 7 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0335231212899892 0.0848814975011648 1.75543112158976 0.625 7.1 7 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0335231212899892 0.0848814975011648 1.75543112158976 0.625 7.1 7 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.82987503433432e-08 5.73674965669236e-07 1.7488068532064 0.622641509433962 7.1 7 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000620557079146029 0.00301383182124505 1.73871272995557 0.619047619047619 7.1 7 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.40084100666384e-05 0.000110744264026814 1.73477899074753 0.617647058823529 7.1 7 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000160493969798435 0.00095959209673602 1.72842448894992 0.615384615384615 7.1 7 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000160493969798435 0.00095959209673602 1.72842448894992 0.615384615384615 7.1 7 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000160493969798435 0.00095959209673602 1.72842448894992 0.615384615384615 7.1 7 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000160493969798435 0.00095959209673602 1.72842448894992 0.615384615384615 7.1 7 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00777874419359811 0.0266085408353128 1.72842448894992 0.615384615384615 7.1 7 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00777874419359811 0.0266085408353128 1.72842448894992 0.615384615384615 7.1 7 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00777874419359811 0.0266085408353128 1.72842448894992 0.615384615384615 7.1 7 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00777874419359811 0.0266085408353128 1.72842448894992 0.615384615384615 7.1 7 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.00535256615383e-06 1.02186907259779e-05 1.72351419210631 0.613636363636364 7.1 7 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.00535256615383e-06 1.02186907259779e-05 1.72351419210631 0.613636363636364 7.1 7 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 4.21268050773178e-05 0.000299732218125116 1.72145503536544 0.612903225806452 7.1 7 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 4.92787424123126e-18 5.84363753772673e-16 1.71754411896552 0.611510791366906 7.1 7 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0019180275911634 0.00805118956408709 1.71642154110999 0.611111111111111 7.1 7 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0019180275911634 0.00805118956408709 1.71642154110999 0.611111111111111 7.1 7 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 8.03478527567788e-07 8.42198435552869e-06 1.70963726624394 0.608695652173913 7.1 7 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 8.03478527567788e-07 8.42198435552869e-06 1.70963726624394 0.608695652173913 7.1 7 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000488339368289857 0.00252693425845988 1.70963726624394 0.608695652173913 7.1 7 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000126827406123326 0.000793659546284502 1.7052759466872 0.607142857142857 7.1 7 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000126827406123326 0.000793659546284502 1.7052759466872 0.607142857142857 7.1 7 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3.3385852020324e-05 0.000241157702664574 1.70223623911734 0.606060606060606 7.1 7 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 3.3385852020324e-05 0.000241157702664574 1.70223623911734 0.606060606060606 7.1 7 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 3.3385852020324e-05 0.000241157702664574 1.70223623911734 0.606060606060606 7.1 7 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.19586733358903e-09 2.57836244802605e-08 1.70103748120247 0.605633802816901 7.1 7 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 3.27588878659472e-10 7.90099956495642e-09 1.69999645459219 0.605263157894737 7.1 7 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.27966927792533e-08 2.1908641093127e-07 1.6941303522644 0.603174603174603 7.1 7 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00149023397304286 0.0064456016524012 1.68521387672617 0.6 7.1 7 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00149023397304286 0.0064456016524012 1.68521387672617 0.6 7.1 7 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0250652418843592 0.0658078214048765 1.68521387672617 0.6 7.1 7 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0250652418843592 0.0658078214048765 1.68521387672617 0.6 7.1 7 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.0250652418843592 0.0658078214048765 1.68521387672617 0.6 7.1 7 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0250652418843592 0.0658078214048765 1.68521387672617 0.6 7.1 7 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0250652418843592 0.0658078214048765 1.68521387672617 0.6 7.1 7 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0250652418843592 0.0658078214048765 1.68521387672617 0.6 7.1 7 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00596850198780371 0.021325594549253 1.68521387672617 0.6 7.1 7 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000297977051963349 0.00163714804997624 1.66440876713696 0.592592592592593 7.1 7 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.88883708770942e-25 6.85135862635083e-23 1.66254283802582 0.591928251121076 7.1 7 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 4.01771188681327e-09 7.52263686175695e-08 1.65443371459419 0.589041095890411 7.1 7 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 6.10679119541603e-05 0.000411846628960996 1.6521704673786 0.588235294117647 7.1 7 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.39233094526374e-10 6.18961260929146e-09 1.6521704673786 0.588235294117647 7.1 7 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 9.23058241961259e-18 9.38222770222051e-16 1.64281855907268 0.584905660377358 7.1 7 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 2.67781479249988e-06 2.45840674175957e-05 1.63840238015044 0.583333333333333 7.1 7 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 4.75930930256447e-05 0.000331985153801433 1.63840238015044 0.583333333333333 7.1 7 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0008893796174451 0.00417685543110356 1.63840238015044 0.583333333333333 7.1 7 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0008893796174451 0.00417685543110356 1.63840238015044 0.583333333333333 7.1 7 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0008893796174451 0.00417685543110356 1.63840238015044 0.583333333333333 7.1 7 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0187278609069684 0.0513444412518279 1.63840238015044 0.583333333333333 7.1 7 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000179544061506118 0.00105574875836036 1.63085213876726 0.580645161290323 7.1 7 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 4.64518464350885e-17 3.88829279277241e-15 1.62796669620044 0.579617834394904 7.1 7 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00347891599264796 0.0136377340428045 1.62608356526209 0.578947368421053 7.1 7 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 6.1196729937913e-15 3.95831575916592e-13 1.61651211196755 0.575539568345324 7.1 7 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0140049087800004 0.0426744864966609 1.60496559688207 0.571428571428571 7.1 7 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0140049087800004 0.0426744864966609 1.60496559688207 0.571428571428571 7.1 7 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0140049087800004 0.0426744864966609 1.60496559688207 0.571428571428571 7.1 7 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0140049087800004 0.0426744864966609 1.60496559688207 0.571428571428571 7.1 7 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.6481263871262e-09 3.16930249848727e-08 1.60029999921671 0.569767441860465 7.1 7 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.64932482718605e-07 1.95582435757145e-06 1.59879265227867 0.569230769230769 7.1 7 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 6.2530645012111e-13 3.29559658711978e-11 1.59844134648824 0.569105691056911 7.1 7 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000403963160295708 0.00215295721760596 1.59159088357472 0.566666666666667 7.1 7 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.33573544610165e-05 0.000107660079063337 1.58752031865509 0.565217391304348 7.1 7 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00201697277132696 0.0083677908268171 1.58752031865509 0.565217391304348 7.1 7 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.97427286495474e-14 2.35641261951275e-12 1.58490352692104 0.564285714285714 7.1 7 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 9.14309920399562e-26 2.60212603345715e-23 1.57988800943079 0.5625 7.1 7 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.29996203418386e-08 2.1908641093127e-07 1.57988800943078 0.5625 7.1 7 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.03267668690242e-05 8.54359840384971e-05 1.57988800943078 0.5625 7.1 7 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0104879079636988 0.0335377371513334 1.57988800943078 0.5625 7.1 7 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0104879079636988 0.0335377371513334 1.57988800943078 0.5625 7.1 7 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0104879079636988 0.0335377371513334 1.57988800943078 0.5625 7.1 7 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0104879079636988 0.0335377371513334 1.57988800943078 0.5625 7.1 7 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 6.02719139451827e-08 7.59966706367247e-07 1.57748330926422 0.561643835616438 7.1 7 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 4.92225579578359e-05 0.000338375362193239 1.57560647010983 0.560975609756098 7.1 7 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 4.92225579578359e-05 0.000338375362193239 1.57560647010983 0.560975609756098 7.1 7 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.67843169876184e-08 6.22187692274588e-07 1.57286628494443 0.56 7.1 7 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.67843169876184e-08 6.22187692274588e-07 1.57286628494443 0.56 7.1 7 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.67843169876184e-08 6.22187692274588e-07 1.57286628494443 0.56 7.1 7 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.67843169876184e-08 6.22187692274588e-07 1.57286628494443 0.56 7.1 7 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.67843169876184e-08 6.22187692274588e-07 1.57286628494443 0.56 7.1 7 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 7.97809618940804e-06 6.63908238451909e-05 1.57286628494443 0.56 7.1 7 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 8.91780450830305e-15 5.51740687622402e-13 1.57064889826452 0.559210526315789 7.1 7 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.40412485920865e-12 6.88989542984105e-11 1.5702124048236 0.559055118110236 7.1 7 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.99464122223611e-34 1.894791486414e-31 1.56956194400967 0.558823529411765 7.1 7 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 3.78997387038982e-05 0.000271011699375111 1.56764081555923 0.558139534883721 7.1 7 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.68506469883376e-17 2.54723137762696e-15 1.56549922974562 0.557377049180328 7.1 7 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.44668790372429e-13 7.91783418076793e-12 1.56484145696002 0.557142857142857 7.1 7 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.26975577996268e-15 2.21564879756519e-13 1.56233369821489 0.55625 7.1 7 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.18126030519539e-08 3.37384066770982e-07 1.5603832191909 0.555555555555556 7.1 7 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.18126030519539e-08 3.37384066770982e-07 1.5603832191909 0.555555555555556 7.1 7 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00116789151365764 0.00530961541193233 1.5603832191909 0.555555555555556 7.1 7 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00116789151365764 0.00530961541193233 1.5603832191909 0.555555555555556 7.1 7 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0593458302347467 0.12604345734932 1.5603832191909 0.555555555555556 7.1 7 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0593458302347467 0.12604345734932 1.5603832191909 0.555555555555556 7.1 7 1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0593458302347467 0.12604345734932 1.5603832191909 0.555555555555556 7.1 7 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0593458302347467 0.12604345734932 1.5603832191909 0.555555555555556 7.1 7 1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.0593458302347467 0.12604345734932 1.5603832191909 0.555555555555556 7.1 7 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0593458302347467 0.12604345734932 1.5603832191909 0.555555555555556 7.1 7 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0593458302347467 0.12604345734932 1.5603832191909 0.555555555555556 7.1 7 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0593458302347467 0.12604345734932 1.5603832191909 0.555555555555556 7.1 7 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 1.6898700158525e-08 2.73259662790694e-07 1.55662325962658 0.55421686746988 7.1 7 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.07076404709323e-11 3.97085073019837e-10 1.55522492755721 0.553719008264463 7.1 7 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.07076404709323e-11 3.97085073019837e-10 1.55522492755721 0.553719008264463 7.1 7 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.30866795004624e-08 2.1908641093127e-07 1.55304023933588 0.552941176470588 7.1 7 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.30866795004624e-08 2.1908641093127e-07 1.55304023933588 0.552941176470588 7.1 7 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.67966617471596e-07 5.28505156081017e-06 1.55106749847931 0.552238805970149 7.1 7 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 6.03487265070266e-08 7.59966706367247e-07 1.54838027135097 0.551282051282051 7.1 7 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 7.8401328809216e-09 1.41221634044955e-07 1.5463573026139 0.550561797752809 7.1 7 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00590952734994307 0.02123549853275 1.54477938699899 0.55 7.1 7 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.32639630381828e-05 0.000107660079063337 1.54202576955336 0.549019607843137 7.1 7 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.32639630381828e-05 0.000107660079063337 1.54202576955336 0.549019607843137 7.1 7 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.60538224885991e-08 5.51662251626629e-07 1.54135415554223 0.548780487804878 7.1 7 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.66144041849869e-08 2.71750542014212e-07 1.53201261520561 0.545454545454545 7.1 7 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 6.26639203562043e-05 0.000420616786164522 1.53201261520561 0.545454545454545 7.1 7 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0430616915803638 0.0993140796091697 1.53201261520561 0.545454545454545 7.1 7 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 9.88161129141023e-08 1.19165532776922e-06 1.5287805210807 0.544303797468354 7.1 7 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 9.88161129141023e-08 1.19165532776922e-06 1.5287805210807 0.544303797468354 7.1 7 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 7.67094569309953e-07 8.39673517021587e-06 1.5282576823252 0.544117647058823 7.1 7 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 4.79871578342831e-05 0.00033310110047895 1.52646184486066 0.543478260869565 7.1 7 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.66543526416902e-18 6.20147260070194e-16 1.52471731703796 0.542857142857143 7.1 7 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00334958286227825 0.0131670066658065 1.52137363871113 0.541666666666667 7.1 7 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00334958286227825 0.0131670066658065 1.52137363871113 0.541666666666667 7.1 7 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 4.52742687114699e-08 6.22187692274588e-07 1.51999682998831 0.541176470588235 7.1 7 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 4.52742687114699e-08 6.22187692274588e-07 1.51999682998831 0.541176470588235 7.1 7 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 4.52742687114699e-08 6.22187692274588e-07 1.51999682998831 0.541176470588235 7.1 7 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 4.52742687114699e-08 6.22187692274588e-07 1.51999682998831 0.541176470588235 7.1 7 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 4.52742687114699e-08 6.22187692274588e-07 1.51999682998831 0.541176470588235 7.1 7 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.15521064426301e-05 0.000163131103552461 1.51237142783118 0.538461538461538 7.1 7 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.15521064426301e-05 0.000163131103552461 1.51237142783118 0.538461538461538 7.1 7 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00252677622414566 0.0102147800197707 1.51237142783118 0.538461538461538 7.1 7 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00252677622414566 0.0102147800197707 1.51237142783118 0.538461538461538 7.1 7 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0315018304059005 0.0807695579596332 1.51237142783118 0.538461538461538 7.1 7 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0315018304059005 0.0807695579596332 1.51237142783118 0.538461538461538 7.1 7 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0315018304059005 0.0807695579596332 1.51237142783118 0.538461538461538 7.1 7 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.94846909959144e-18 2.52061048065329e-16 1.51140258002347 0.538116591928251 7.1 7 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.81203046063386e-15 1.35711544499052e-13 1.51119722641206 0.53804347826087 7.1 7 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00017355942925605 0.00102479281257825 1.50710184097462 0.536585365853659 7.1 7 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 7.2597145977627e-08 9.06190690580379e-07 1.50232244824426 0.534883720930233 7.1 7 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000132343146916616 0.000818801295923235 1.50232244824426 0.534883720930233 7.1 7 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 7.41898099899566e-06 6.21012350680637e-05 1.49796789042326 0.533333333333333 7.1 7 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 7.41898099899566e-06 6.21012350680637e-05 1.49796789042326 0.533333333333333 7.1 7 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 7.41898099899566e-06 6.21012350680637e-05 1.49796789042326 0.533333333333333 7.1 7 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 7.41898099899566e-06 6.21012350680637e-05 1.49796789042326 0.533333333333333 7.1 7 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 7.41898099899566e-06 6.21012350680637e-05 1.49796789042326 0.533333333333333 7.1 7 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 7.41898099899566e-06 6.21012350680637e-05 1.49796789042326 0.533333333333333 7.1 7 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 7.41898099899566e-06 6.21012350680637e-05 1.49796789042326 0.533333333333333 7.1 7 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0231893736853682 0.0620272157035319 1.49796789042326 0.533333333333333 7.1 7 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0231893736853682 0.0620272157035319 1.49796789042326 0.533333333333333 7.1 7 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0231893736853682 0.0620272157035319 1.49796789042326 0.533333333333333 7.1 7 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0231893736853682 0.0620272157035319 1.49796789042326 0.533333333333333 7.1 7 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 7.70220425381593e-05 0.000505080030100464 1.49398393326788 0.531914893617021 7.1 7 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 3.30261818336206e-07 3.75970053993936e-06 1.49322748570673 0.531645569620253 7.1 7 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.00109193591833724 0.00501233810256092 1.4921164533513 0.53125 7.1 7 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.91289024394736e-20 5.92148973876727e-18 1.4907661217193 0.530769230769231 7.1 7 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 5.43484285100312e-11 1.51642772097597e-09 1.48945670922768 0.53030303030303 7.1 7 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0171547914989788 0.0502289471256107 1.48695342064074 0.529411764705882 7.1 7 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0171547914989788 0.0502289471256107 1.48695342064074 0.529411764705882 7.1 7 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0171547914989788 0.0502289471256107 1.48695342064074 0.529411764705882 7.1 7 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 3.42724294723681e-05 0.000246311450197878 1.4838361178721 0.528301886792453 7.1 7 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000475785422591804 0.00247095859981072 1.4782577866019 0.526315789473684 7.1 7 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0127415750989862 0.0398841606382196 1.4782577866019 0.526315789473684 7.1 7 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0127415750989862 0.0398841606382196 1.4782577866019 0.526315789473684 7.1 7 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0127415750989862 0.0398841606382196 1.4782577866019 0.526315789473684 7.1 7 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0127415750989862 0.0398841606382196 1.4782577866019 0.526315789473684 7.1 7 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.52225566868824e-14 4.85086792661735e-12 1.4757522649297 0.525423728813559 7.1 7 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000361247951051587 0.0019620451692611 1.4745621421354 0.525 7.1 7 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.94304243820852e-10 1.13450796605979e-08 1.47229706972044 0.524193548387097 7.1 7 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00949522395348466 0.0310613877834682 1.47121846380856 0.523809523809524 7.1 7 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.000158720448839341 0.00095959209673602 1.46540337106624 0.521739130434783 7.1 7 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 1.29791806359432e-09 2.71608441837458e-08 1.46237567815081 0.520661157024793 7.1 7 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 1.79273393497386e-06 1.71212106675691e-05 1.46051869316268 0.52 7.1 7 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.52397001053073e-10 1.07293488749754e-08 1.45877687003428 0.51937984496124 7.1 7 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 8.04912067710402e-07 8.42198435552869e-06 1.45635767124484 0.518518518518518 7.1 7 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 8.04912067710402e-07 8.42198435552869e-06 1.45635767124484 0.518518518518518 7.1 7 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00300073030384561 0.011994492197675 1.45277058338463 0.517241379310345 7.1 7 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.62872595336013e-07 1.9476277576735e-06 1.4496463455709 0.516129032258065 7.1 7 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 1.80874943743815e-05 0.000140647565545054 1.4496463455709 0.516129032258065 7.1 7 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00170490813814817 0.0072637253909726 1.44690080324974 0.515151515151515 7.1 7 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00170490813814817 0.0072637253909726 1.44690080324974 0.515151515151515 7.1 7 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00170490813814817 0.0072637253909726 1.44690080324974 0.515151515151515 7.1 7 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00128765195671605 0.00565533560002142 1.44446903719386 0.514285714285714 7.1 7 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00128765195671605 0.00565533560002142 1.44446903719386 0.514285714285714 7.1 7 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00128765195671605 0.00565533560002142 1.44446903719386 0.514285714285714 7.1 7 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.94676995296621e-08 3.07805960341213e-07 1.44299659169213 0.513761467889908 7.1 7 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0005583208989369 0.00280738741762264 1.43859721183941 0.51219512195122 7.1 7 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0005583208989369 0.00280738741762264 1.43859721183941 0.51219512195122 7.1 7 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000423354981346743 0.00223953211322088 1.43700408092929 0.511627906976744 7.1 7 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000423354981346743 0.00223953211322088 1.43700408092929 0.511627906976744 7.1 7 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 3.24073080242619e-07 3.74923571695322e-06 1.43487413416902 0.510869565217391 7.1 7 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.000185395211608878 0.00107825005648079 1.43300499721613 0.510204081632653 7.1 7 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.73721597317271e-05 0.000331985153801433 1.42814735315777 0.508474576271186 7.1 7 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.73721597317271e-05 0.000331985153801433 1.42814735315777 0.508474576271186 7.1 7 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.42487607256275e-06 1.38876619949095e-05 1.42086660194559 0.505882352941176 7.1 7 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.42487607256275e-06 1.38876619949095e-05 1.42086660194559 0.505882352941176 7.1 7 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.42487607256275e-06 1.38876619949095e-05 1.42086660194559 0.505882352941176 7.1 7 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.42487607256275e-06 1.38876619949095e-05 1.42086660194559 0.505882352941176 7.1 7 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 6.37444771447834e-10 1.43981572979408e-08 1.41416549095902 0.503496503496504 7.1 7 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.1421518456952e-10 3.06656995551748e-09 1.40434489727181 0.5 7.1 7 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00258267424545633 0.0104111769158197 1.40434489727181 0.5 7.1 7 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0195736228480292 0.053175748502831 1.40434489727181 0.5 7.1 7 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0489987520318005 0.109980833822049 1.40434489727181 0.5 7.1 7 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0489987520318005 0.109980833822049 1.40434489727181 0.5 7.1 7 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0489987520318005 0.109980833822049 1.40434489727181 0.5 7.1 7 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0489987520318005 0.109980833822049 1.40434489727181 0.5 7.1 7 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0489987520318005 0.109980833822049 1.40434489727181 0.5 7.1 7 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0936264185851341 0.181760427894469 1.40434489727181 0.5 7.1 7 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0936264185851341 0.181760427894469 1.40434489727181 0.5 7.1 7 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0936264185851341 0.181760427894469 1.40434489727181 0.5 7.1 7 1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0936264185851341 0.181760427894469 1.40434489727181 0.5 7.1 7 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0936264185851341 0.181760427894469 1.40434489727181 0.5 7.1 7 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0936264185851341 0.181760427894469 1.40434489727181 0.5 7.1 7 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0936264185851341 0.181760427894469 1.40434489727181 0.5 7.1 7 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.93823272538897e-10 5.10760216338612e-09 1.40434489727181 0.5 7.1 7 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 6.06028366048111e-09 1.10561328831598e-07 1.40434489727181 0.5 7.1 7 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.27306451013611e-07 3.75610548219652e-06 1.40434489727181 0.5 7.1 7 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.39804114300298e-05 0.000110744264026814 1.40434489727181 0.5 7.1 7 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000278808168256109 0.00153776753266838 1.40434489727181 0.5 7.1 7 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00194821730755349 0.0081061790311363 1.40434489727181 0.5 7.1 7 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.00194821730755349 0.0081061790311363 1.40434489727181 0.5 7.1 7 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00455864727881117 0.0172985468739955 1.40434489727181 0.5 7.1 7 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0264430916391494 0.0692974574631852 1.40434489727181 0.5 7.1 7 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0358908394070376 0.0894442460178887 1.40434489727181 0.5 7.1 7 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0358908394070376 0.0894442460178887 1.40434489727181 0.5 7.1 7 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0358908394070376 0.0894442460178887 1.40434489727181 0.5 7.1 7 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0358908394070376 0.0894442460178887 1.40434489727181 0.5 7.1 7 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0358908394070376 0.0894442460178887 1.40434489727181 0.5 7.1 7 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0358908394070376 0.0894442460178887 1.40434489727181 0.5 7.1 7 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0673955222537591 0.140210275098098 1.40434489727181 0.5 7.1 7 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0673955222537591 0.140210275098098 1.40434489727181 0.5 7.1 7 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0673955222537591 0.140210275098098 1.40434489727181 0.5 7.1 7 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0673955222537591 0.140210275098098 1.40434489727181 0.5 7.1 7 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0673955222537591 0.140210275098098 1.40434489727181 0.5 7.1 7 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0673955222537591 0.140210275098098 1.40434489727181 0.5 7.1 7 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0673955222537591 0.140210275098098 1.40434489727181 0.5 7.1 7 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00810433615932855 0.0273281288026648 1.40434489727181 0.5 7.1 7 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00810433615932855 0.0273281288026648 1.40434489727181 0.5 7.1 7 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 7.98961805617959e-05 0.000519142762280528 1.38205370842622 0.492063492063492 7.1 7 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.000180862341968504 0.00105912392025177 1.37970726749511 0.491228070175439 7.1 7 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.20564339901832e-06 1.21675926014402e-05 1.37568479732749 0.489795918367347 7.1 7 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.51137491085841e-06 3.18260286506466e-05 1.37313723288799 0.488888888888889 7.1 7 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.00164056265179075 0.00707430501060072 1.3700925827042 0.48780487804878 7.1 7 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00216926356210707 0.00897343618859989 1.36833605375202 0.487179487179487 7.1 7 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00287151422899293 0.0115103232333998 1.36638962977798 0.486486486486487 7.1 7 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 1.74624786506054e-06 1.67899372431159e-05 1.36178899129387 0.484848484848485 7.1 7 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.000262595514088485 0.00146538594724672 1.35591921115899 0.482758620689655 7.1 7 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.000262595514088485 0.00146538594724672 1.35591921115899 0.482758620689655 7.1 7 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00893861356781259 0.029307942642851 1.35591921115899 0.482758620689655 7.1 7 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00893861356781259 0.029307942642851 1.35591921115899 0.482758620689655 7.1 7 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0119246142457961 0.0377922629660753 1.35233212329878 0.481481481481481 7.1 7 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0119246142457961 0.0377922629660753 1.35233212329878 0.481481481481481 7.1 7 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0119246142457961 0.0377922629660753 1.35233212329878 0.481481481481481 7.1 7 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.1194748551463e-09 5.91868362516424e-08 1.35101534421085 0.481012658227848 7.1 7 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.000596048838707203 0.00290838331006321 1.35033163199212 0.480769230769231 7.1 7 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 2.50591378058831e-06 2.31552942193322e-05 1.34817110138094 0.48 7.1 7 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0159436452441691 0.0473846126795913 1.34817110138094 0.48 7.1 7 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0213722858025242 0.0578192915174289 1.34328642347738 0.478260869565217 7.1 7 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.000127164003199484 0.000793659546284502 1.34146378246859 0.477611940298507 7.1 7 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.000127164003199484 0.000793659546284502 1.34146378246859 0.477611940298507 7.1 7 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0287358036612517 0.0746187018429948 1.33747133073506 0.476190476190476 7.1 7 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.94821260998136e-10 7.36018691930434e-09 1.3367561054245 0.475935828877005 7.1 7 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.73603330489241e-08 6.24016240079805e-07 1.33462564705264 0.475177304964539 7.1 7 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00413155691255785 0.0157619450042086 1.33043200794171 0.473684210526316 7.1 7 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.038774456525296 0.0962932838315816 1.33043200794171 0.473684210526316 7.1 7 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00546775454869409 0.0201049476041129 1.32632573631226 0.472222222222222 7.1 7 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00546775454869409 0.0201049476041129 1.32632573631226 0.472222222222222 7.1 7 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00546775454869409 0.0201049476041129 1.32632573631226 0.472222222222222 7.1 7 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.85732583455098e-06 3.45218532236858e-05 1.32332499935228 0.471153846153846 7.1 7 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.94540511916186e-08 3.07805960341213e-07 1.32280229033345 0.470967741935484 7.1 7 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00724469945954254 0.025205885894692 1.32173637390288 0.470588235294118 7.1 7 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00724469945954254 0.025205885894692 1.32173637390288 0.470588235294118 7.1 7 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.052545104214201 0.116466796412474 1.32173637390288 0.470588235294118 7.1 7 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00111566336303484 0.00510478767073498 1.32173637390288 0.470588235294118 7.1 7 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.27860030322176e-09 2.7155943753501e-08 1.31993072311886 0.469945355191257 7.1 7 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00961179585307241 0.0313706089424817 1.31657334119232 0.46875 7.1 7 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0715819580849286 0.145308311490518 1.31072190412035 0.466666666666667 7.1 7 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0715819580849286 0.145308311490518 1.31072190412035 0.466666666666667 7.1 7 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0715819580849286 0.145308311490518 1.31072190412035 0.466666666666667 7.1 7 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0715819580849286 0.145308311490518 1.31072190412035 0.466666666666667 7.1 7 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0715819580849286 0.145308311490518 1.31072190412035 0.466666666666667 7.1 7 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0715819580849286 0.145308311490518 1.31072190412035 0.466666666666667 7.1 7 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0715819580849286 0.145308311490518 1.31072190412035 0.466666666666667 7.1 7 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 3.78341436555533e-08 5.72744536402685e-07 1.30595130574321 0.464968152866242 7.1 7 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00440749200028259 0.0167696821294174 1.30158795356899 0.463414634146341 7.1 7 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.00119034920234806 0.0053773552855279 1.30031934932575 0.462962962962963 7.1 7 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0981615438376379 0.187747146345375 1.29631836671244 0.461538461538462 7.1 7 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0981615438376379 0.187747146345375 1.29631836671244 0.461538461538462 7.1 7 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0981615438376379 0.187747146345375 1.29631836671244 0.461538461538462 7.1 7 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0981615438376379 0.187747146345375 1.29631836671244 0.461538461538462 7.1 7 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0981615438376379 0.187747146345375 1.29631836671244 0.461538461538462 7.1 7 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0076745588204401 0.0265533596623614 1.29047909479031 0.459459459459459 7.1 7 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0076745588204401 0.0265533596623614 1.29047909479031 0.459459459459459 7.1 7 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.55076790722387e-10 6.48168344996351e-09 1.28944395113139 0.459090909090909 7.1 7 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0302823901362738 0.078348802116214 1.28731615583249 0.458333333333333 7.1 7 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0302823901362738 0.078348802116214 1.28731615583249 0.458333333333333 7.1 7 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.33913099045753e-05 0.000107660079063337 1.28397247750565 0.457142857142857 7.1 7 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00352939135685689 0.0137975931340861 1.28222794968296 0.456521739130435 7.1 7 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.12850443535745e-06 2.85375757148311e-05 1.27875307719059 0.455284552845528 7.1 7 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000592066632126162 0.00290838331006321 1.27667717933801 0.454545454545455 7.1 7 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0134126213630086 0.0414016490229093 1.27667717933801 0.454545454545455 7.1 7 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0405619433384783 0.098310560651751 1.27667717933801 0.454545454545455 7.1 7 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.135763691089109 0.237336280614008 1.27667717933801 0.454545454545455 7.1 7 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 1.08733706958065e-05 8.94381878620387e-05 1.27667717933801 0.454545454545455 7.1 7 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.40968112026921e-05 0.000110827416250999 1.27431296233923 0.453703703703704 7.1 7 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.38595408423031e-35 1.69760633092987e-32 1.2740776104208 0.453619909502262 7.1 7 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.000772249168356516 0.00370003557768122 1.27268756315258 0.453125 7.1 7 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 2.84598813152848e-11 8.26498185952047e-10 1.26982910251397 0.452107279693487 7.1 7 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.017759764786818 0.0513444412518279 1.26844055237454 0.451612903225806 7.1 7 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.017759764786818 0.0513444412518279 1.26844055237454 0.451612903225806 7.1 7 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00801301316303929 0.0271777054525918 1.26391040754463 0.45 7.1 7 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.47481080357925e-05 0.000182469211061828 1.2599729919448 0.448598130841121 7.1 7 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 7.30290716651234e-17 5.77335383219281e-15 1.25929518957237 0.448356807511737 7.1 7 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00023483727750445 0.00133669378355533 1.25206653491703 0.44578313253012 7.1 7 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 6.77385386225621e-07 7.58991657164613e-06 1.2503199730549 0.445161290322581 7.1 7 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00631425015246567 0.0224629449173966 1.24830657535272 0.444444444444444 7.1 7 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0138789774888502 0.042656123038086 1.24830657535272 0.444444444444444 7.1 7 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0312538040594787 0.0805691361895619 1.24830657535272 0.444444444444444 7.1 7 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0312538040594787 0.0805691361895619 1.24830657535272 0.444444444444444 7.1 7 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0734267142742426 0.147579398887355 1.24830657535272 0.444444444444444 7.1 7 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000833965508217439 0.00395577639397805 1.2438483375836 0.442857142857143 7.1 7 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000833965508217439 0.00395577639397805 1.2438483375836 0.442857142857143 7.1 7 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 5.03241595235864e-08 6.51011627291486e-07 1.24343037779275 0.442708333333333 7.1 7 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 5.55265146092665e-05 0.000379876107158588 1.24230510143275 0.442307692307692 7.1 7 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00380741142078532 0.0148436889089795 1.24230510143275 0.442307692307692 7.1 7 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.55188448448599e-19 2.76041452677946e-17 1.24129361706422 0.441947565543071 7.1 7 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0182820333920607 0.0513444412518279 1.23912785053395 0.441176470588235 7.1 7 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.24249508839193e-19 6.70785612309079e-17 1.23881374968464 0.44106463878327 7.1 7 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00230806421608036 0.00951992863618073 1.23772770607007 0.440677966101695 7.1 7 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.46597041760955e-27 5.21518976064597e-25 1.23711816814725 0.440460947503201 7.1 7 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0415485468372135 0.098310560651751 1.23582350959919 0.44 7.1 7 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0415485468372135 0.098310560651751 1.23582350959919 0.44 7.1 7 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0415485468372135 0.098310560651751 1.23582350959919 0.44 7.1 7 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 7.49224595786827e-07 8.28008751727397e-06 1.23308332443378 0.439024390243902 7.1 7 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.0108347253773706 0.0345690901614313 1.23308332443378 0.439024390243902 7.1 7 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0993417170566216 0.189241316427808 1.22880178511283 0.4375 7.1 7 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0993417170566216 0.189241316427808 1.22880178511283 0.4375 7.1 7 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0993417170566216 0.189241316427808 1.22880178511283 0.4375 7.1 7 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 7.32468906452998e-11 2.00442933438965e-09 1.22700441536376 0.436860068259386 7.1 7 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.60887003680887e-09 3.13619460599866e-08 1.22601538650713 0.436507936507937 7.1 7 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.60887003680887e-09 3.13619460599866e-08 1.22601538650713 0.436507936507937 7.1 7 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.60887003680887e-09 3.13619460599866e-08 1.22601538650713 0.436507936507937 7.1 7 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00390494712817103 0.0151409802817095 1.22561009216449 0.436363636363636 7.1 7 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.014197070034297 0.0430755451147221 1.22430067967286 0.435897435897436 7.1 7 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.014197070034297 0.0430755451147221 1.22430067967286 0.435897435897436 7.1 7 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 2.25753677296907e-05 0.00016731639728828 1.22313910407545 0.435483870967742 7.1 7 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 2.25753677296907e-05 0.00016731639728828 1.22313910407545 0.435483870967742 7.1 7 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 2.25753677296907e-05 0.00016731639728828 1.22313910407545 0.435483870967742 7.1 7 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.91298324010211e-07 8.42198435552869e-06 1.22260614586016 0.435294117647059 7.1 7 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0553232183661354 0.121915640708709 1.22116947588853 0.434782608695652 7.1 7 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0553232183661354 0.121915640708709 1.22116947588853 0.434782608695652 7.1 7 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.000158008607444353 0.00095959209673602 1.21993597136743 0.434343434343434 7.1 7 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00306816871034982 0.0122297032908342 1.2170989109689 0.433333333333333 7.1 7 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.00186297484871467 0.00786650804071505 1.21570155286216 0.432835820895522 7.1 7 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.9758577930158e-11 5.85759508221142e-10 1.21480141420445 0.432515337423313 7.1 7 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000694621905744005 0.00336206453018272 1.21363139270403 0.432098765432099 7.1 7 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.33012092062226e-06 1.3329310352433e-05 1.21322103551292 0.431952662721893 7.1 7 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000426018199376134 0.00224527369523051 1.21284332037111 0.431818181818182 7.1 7 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.00026189141115224 0.00146538594724672 1.21217138501356 0.431578947368421 7.1 7 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00397815668217406 0.015341238370552 1.21064215282052 0.431034482758621 7.1 7 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00241029735668026 0.00991287034264744 1.20989714226494 0.430769230769231 7.1 7 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000127849699175749 0.00079445468090433 1.20747411728043 0.429906542056075 7.1 7 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 7.89513840781824e-05 0.000515356970381897 1.20724385905822 0.429824561403509 7.1 7 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00858052336970503 0.0285282354090894 1.20372419766155 0.428571428571429 7.1 7 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0419465291617374 0.0983359324500038 1.20372419766155 0.428571428571429 7.1 7 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0419465291617374 0.0983359324500038 1.20372419766155 0.428571428571429 7.1 7 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.0419465291617374 0.0983359324500038 1.20372419766155 0.428571428571429 7.1 7 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0419465291617374 0.0983359324500038 1.20372419766155 0.428571428571429 7.1 7 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.135033637692016 0.237336280614008 1.20372419766155 0.428571428571429 7.1 7 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.135033637692016 0.237336280614008 1.20372419766155 0.428571428571429 7.1 7 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0143905410746289 0.0434771548815221 1.20372419766155 0.428571428571429 7.1 7 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0737955489385071 0.147902910055628 1.20372419766155 0.428571428571429 7.1 7 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0737955489385071 0.147902910055628 1.20372419766155 0.428571428571429 7.1 7 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.35339375222474e-05 0.000424454427672104 1.19714646980548 0.426229508196721 7.1 7 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.00402947733545532 0.0154553807233232 1.19714646980548 0.426229508196721 7.1 7 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00402947733545532 0.0154553807233232 1.19714646980548 0.426229508196721 7.1 7 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000715639136818291 0.00345204912438111 1.19450025744958 0.425287356321839 7.1 7 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0319698285008255 0.0818220610731558 1.19156536738214 0.424242424242424 7.1 7 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.87576967348825e-17 2.55763765335861e-15 1.19037290766997 0.423817863397548 7.1 7 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.77296300321705e-07 3.2610961599817e-06 1.1903494843542 0.423809523809524 7.1 7 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 5.97999079620295e-06 5.28542043664398e-05 1.18895457560435 0.423312883435583 7.1 7 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0553979089616415 0.121915640708709 1.18829183615307 0.423076923076923 7.1 7 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.000722469041034875 0.00347322109929941 1.18589124658508 0.422222222222222 7.1 7 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0144798174806203 0.0435696225083447 1.18589124658508 0.422222222222222 7.1 7 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.001930358044304 0.00807911616777821 1.18260622928152 0.421052631578947 7.1 7 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.08488113875624e-08 1.92973232556267e-07 1.17620222442982 0.418772563176895 7.1 7 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.00118545935098446 0.00537232056194549 1.17573061166942 0.418604651162791 7.1 7 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00867516099875479 0.0285758196787687 1.17454300499097 0.418181818181818 7.1 7 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00867516099875479 0.0285758196787687 1.17454300499097 0.418181818181818 7.1 7 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00867516099875479 0.0285758196787687 1.17454300499097 0.418181818181818 7.1 7 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.00673330666132628 0.023541757688126 1.17028741439317 0.416666666666667 7.1 7 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0144823833074118 0.0435696225083447 1.17028741439317 0.416666666666667 7.1 7 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0732095242446081 0.147350994342401 1.17028741439317 0.416666666666667 7.1 7 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.184598097400074 0.309402935924977 1.17028741439317 0.416666666666667 7.1 7 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.184598097400074 0.309402935924977 1.17028741439317 0.416666666666667 7.1 7 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.0132046513931e-41 2.86479021893238e-38 1.16953190282804 0.416397675919948 7.1 7 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00865988114733959 0.0285758196787687 1.1622164667077 0.413793103448276 7.1 7 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0187184840301603 0.0513444412518279 1.1601110020941 0.41304347826087 7.1 7 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.00671668808069336 0.0235414954158292 1.15914181997038 0.412698412698413 7.1 7 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0415512850769608 0.098310560651751 1.15651932716502 0.411764705882353 7.1 7 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0415512850769608 0.098310560651751 1.15651932716502 0.411764705882353 7.1 7 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.132099346046316 0.235265794022413 1.15651932716502 0.411764705882353 7.1 7 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.132099346046316 0.235265794022413 1.15651932716502 0.411764705882353 7.1 7 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.132099346046316 0.235265794022413 1.15651932716502 0.411764705882353 7.1 7 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.132099346046316 0.235265794022413 1.15651932716502 0.411764705882353 7.1 7 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.132099346046316 0.235265794022413 1.15651932716502 0.411764705882353 7.1 7 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0968034297385271 0.186402274043199 1.14900946140421 0.409090909090909 7.1 7 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0185526315403131 0.0513444412518279 1.14640399777291 0.408163265306122 7.1 7 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.25141125805192e-11 3.97085073019837e-10 1.1461469565178 0.408071748878924 7.1 7 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0142846709016562 0.0432491206235251 1.14428102740666 0.407407407407407 7.1 7 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0719969810818784 0.145321566070231 1.14428102740666 0.407407407407407 7.1 7 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0719969810818784 0.145321566070231 1.14428102740666 0.407407407407407 7.1 7 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0719969810818784 0.145321566070231 1.14428102740666 0.407407407407407 7.1 7 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0719969810818784 0.145321566070231 1.14428102740666 0.407407407407407 7.1 7 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.0085335784928614 0.0284385999890908 1.14103022903334 0.40625 7.1 7 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.00661638361250419 0.0232471947668974 1.13975817749596 0.405797101449275 7.1 7 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00661638361250419 0.0232471947668974 1.13975817749596 0.405797101449275 7.1 7 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0409548342321284 0.098310560651751 1.13865802481498 0.405405405405405 7.1 7 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000271580786526682 0.00150373330438703 1.13634014588406 0.404580152671756 7.1 7 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000271580786526682 0.00150373330438703 1.13634014588406 0.404580152671756 7.1 7 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000906805780692415 0.00423076926532887 1.13378303632953 0.403669724770642 7.1 7 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00653911218364701 0.023147155814253 1.1312778339134 0.402777777777778 7.1 7 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.000896994888277001 0.00419876225663873 1.1284914353077 0.401785714285714 7.1 7 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000550804492389282 0.0027893053119927 1.1280803273167 0.401639344262295 7.1 7 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.000432021986545533 0.00226851397363208 1.12789905135216 0.401574803149606 7.1 7 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.90849572452427e-05 0.000146799427891786 1.12640163635343 0.401041666666667 7.1 7 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.00831089828241427 0.0279584119524244 1.12347591781745 0.4 7.1 7 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0401834068350324 0.098310560651751 1.12347591781745 0.4 7.1 7 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0401834068350324 0.098310560651751 1.12347591781745 0.4 7.1 7 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0529934309285874 0.117277841697325 1.12347591781745 0.4 7.1 7 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0943168425162045 0.18186025325279 1.12347591781745 0.4 7.1 7 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0943168425162045 0.18186025325279 1.12347591781745 0.4 7.1 7 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0943168425162045 0.18186025325279 1.12347591781745 0.4 7.1 7 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0943168425162045 0.18186025325279 1.12347591781745 0.4 7.1 7 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0943168425162045 0.18186025325279 1.12347591781745 0.4 7.1 7 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.128057774099814 0.23272824079698 1.12347591781745 0.4 7.1 7 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.128057774099814 0.23272824079698 1.12347591781745 0.4 7.1 7 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.177334757430074 0.297930767205425 1.12347591781745 0.4 7.1 7 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.177334757430074 0.297930767205425 1.12347591781745 0.4 7.1 7 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.0136432503691891 0.0420223923709007 1.11455944227921 0.396825396825397 7.1 7 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.00140394281983774 0.0061282534743224 1.11335451315243 0.396396396396396 7.1 7 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 2.08961908169007e-06 1.94348232238233e-05 1.11246144803492 0.396078431372549 7.1 7 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 9.49572293335175e-05 0.000608667285322502 1.11041224435445 0.395348837209302 7.1 7 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0080215293675956 0.0271777054525918 1.10869333995143 0.394736842105263 7.1 7 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0517054992679263 0.114834942960423 1.10869333995143 0.394736842105263 7.1 7 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0684804137067848 0.141746270789017 1.10645355542627 0.393939393939394 7.1 7 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000832074602790563 0.00395577639397805 1.10578338367859 0.393700787401575 7.1 7 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0173164925830801 0.0504946084953341 1.10505827982044 0.39344262295082 7.1 7 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.0173164925830801 0.0504946084953341 1.10505827982044 0.39344262295082 7.1 7 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.0224868318449568 0.0606037153700258 1.10341384785642 0.392857142857143 7.1 7 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0914413911478517 0.179230164742966 1.10341384785642 0.392857142857143 7.1 7 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00785910135568767 0.02675478762953 1.10214409659306 0.392405063291139 7.1 7 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00785910135568767 0.02675478762953 1.10214409659306 0.392405063291139 7.1 7 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.0130767207915363 0.0404525514920786 1.09905252829968 0.391304347826087 7.1 7 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.123469279906493 0.22525228885505 1.09905252829968 0.391304347826087 7.1 7 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00597955883707094 0.021325594549253 1.09764888522394 0.390804597701149 7.1 7 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00597955883707094 0.021325594549253 1.09764888522394 0.390804597701149 7.1 7 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0169186810591428 0.049845306722899 1.0971444509936 0.390625 7.1 7 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00768797201749326 0.0265533596623614 1.09607406616336 0.390243902439024 7.1 7 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0502929645322858 0.111998260609457 1.09607406616336 0.390243902439024 7.1 7 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0502929645322858 0.111998260609457 1.09607406616336 0.390243902439024 7.1 7 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0502929645322858 0.111998260609457 1.09607406616336 0.390243902439024 7.1 7 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0502929645322858 0.111998260609457 1.09607406616336 0.390243902439024 7.1 7 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0502929645322858 0.111998260609457 1.09607406616336 0.390243902439024 7.1 7 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.19084122254118e-10 7.82856389599327e-09 1.09607406616336 0.390243902439024 7.1 7 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0219424935742208 0.0592488963114159 1.09491297075429 0.389830508474576 7.1 7 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.0127684446166828 0.0398841606382196 1.09226825343363 0.388888888888889 7.1 7 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.0285388610442977 0.0742427774516191 1.09226825343363 0.388888888888889 7.1 7 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.169436475355818 0.287978755602081 1.09226825343363 0.388888888888889 7.1 7 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.169436475355818 0.287978755602081 1.09226825343363 0.388888888888889 7.1 7 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.169436475355818 0.287978755602081 1.09226825343363 0.388888888888889 7.1 7 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.169436475355818 0.287978755602081 1.09226825343363 0.388888888888889 7.1 7 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.13859445319058e-12 5.78649966746497e-11 1.09202558108228 0.388802488335925 7.1 7 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 7.81898887193469e-19 1.11264211647631e-16 1.09086250278571 0.388388388388388 7.1 7 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.0165010518086679 0.0487157608376233 1.08993932325573 0.388059701492537 7.1 7 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.0213724155573912 0.0578192915174289 1.08723475917817 0.387096774193548 7.1 7 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.088348945923852 0.173407655240885 1.08723475917817 0.387096774193548 7.1 7 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.3699442045955e-05 0.000109518573210079 1.08286835452284 0.385542168674699 7.1 7 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.036150205612485 0.0899331164100806 1.0802653055937 0.384615384615385 7.1 7 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.238620943376597 0.377286224916553 1.0802653055937 0.384615384615385 7.1 7 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.238620943376597 0.377286224916553 1.0802653055937 0.384615384615385 7.1 7 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.238620943376597 0.377286224916553 1.0802653055937 0.384615384615385 7.1 7 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00412895630367732 0.0157619450042086 1.07622693061952 0.383177570093458 7.1 7 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.0472582046397722 0.107083479621649 1.07566843195287 0.382978723404255 7.1 7 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0851508266681042 0.1673613623601 1.07391080379609 0.382352941176471 7.1 7 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.0350331214664992 0.0885473034579544 1.07240883064393 0.381818181818182 7.1 7 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.0151807941573604 0.0455744094639744 1.07173689528638 0.381578947368421 7.1 7 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.161449912660619 0.278476637231589 1.06997706458804 0.380952380952381 7.1 7 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.0195812313531156 0.053175748502831 1.06809330215039 0.380281690140845 7.1 7 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.0065714567603936 0.02320392796536 1.06730212192657 0.38 7.1 7 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 5.81878484731275e-09 1.07534166723715e-07 1.06673470984687 0.37979797979798 7.1 7 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.113749967456727 0.212144434719427 1.06536509448206 0.379310344827586 7.1 7 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.00841366281307274 0.0281709227835353 1.06434560635337 0.378947368421053 7.1 7 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.00841366281307274 0.0281709227835353 1.06434560635337 0.378947368421053 7.1 7 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.0189753322330982 0.0517277735013385 1.06274748982731 0.378378378378378 7.1 7 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.0189753322330982 0.0517277735013385 1.06274748982731 0.378378378378378 7.1 7 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0441227151487092 0.101219533754241 1.05988294133721 0.377358490566038 7.1 7 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0104504545542653 0.0335377371513334 1.05703379364545 0.376344086021505 7.1 7 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.00265260387179481 0.010662868106113 1.05589841900136 0.37593984962406 7.1 7 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.153625133303624 0.265947158991553 1.05325867295386 0.375 7.1 7 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.224130581654146 0.3575536072801 1.05325867295386 0.375 7.1 7 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.224130581654146 0.3575536072801 1.05325867295386 0.375 7.1 7 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.0554317776096519 0.121915640708709 1.04637462933978 0.372549019607843 7.1 7 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0755432854683861 0.151192820283423 1.04509387703949 0.372093023255814 7.1 7 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.104152924150546 0.198141191265009 1.04322763797334 0.371428571428571 7.1 7 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0121038673339562 0.038275118258266 1.04240033611928 0.371134020618557 7.1 7 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.146078937697176 0.253500400418392 1.0402554794606 0.37037037037037 7.1 7 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.00649779975470113 0.0230582769350117 1.03850715092369 0.369747899159664 7.1 7 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.210741211487184 0.338852818018376 1.03478045062133 0.368421052631579 7.1 7 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.210741211487184 0.338852818018376 1.03478045062133 0.368421052631579 7.1 7 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.000562751735685724 0.00281970323901685 1.02985292466599 0.366666666666667 7.1 7 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.138863236569888 0.242456914894419 1.02985292466599 0.366666666666667 7.1 7 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0243772479839376 0.0647179550021329 1.02434568977473 0.364705882352941 7.1 7 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0243772479839376 0.0647179550021329 1.02434568977473 0.364705882352941 7.1 7 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000202370396228287 0.00115651836880663 1.02434568977473 0.364705882352941 7.1 7 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.023445819522032 0.0625954993993462 1.02134174347041 0.363636363636364 7.1 7 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.198390760044671 0.320442737279872 1.02134174347041 0.363636363636364 7.1 7 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.198390760044671 0.320442737279872 1.02134174347041 0.363636363636364 7.1 7 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.198390760044671 0.320442737279872 1.02134174347041 0.363636363636364 7.1 7 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.198390760044671 0.320442737279872 1.02134174347041 0.363636363636364 7.1 7 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.198390760044671 0.320442737279872 1.02134174347041 0.363636363636364 7.1 7 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.198390760044671 0.320442737279872 1.02134174347041 0.363636363636364 7.1 7 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.0637220119711929 0.133938586462345 1.02134174347041 0.363636363636364 7.1 7 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0637220119711929 0.133938586462345 1.02134174347041 0.363636363636364 7.1 7 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.0637220119711929 0.133938586462345 1.02134174347041 0.363636363636364 7.1 7 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0610135564690648 0.128816455275192 1.01693940836924 0.362068965517241 7.1 7 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0610135564690648 0.128816455275192 1.01693940836924 0.362068965517241 7.1 7 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0610135564690648 0.128816455275192 1.01693940836924 0.362068965517241 7.1 7 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.0416593591517961 0.098310560651751 1.01424909247408 0.361111111111111 7.1 7 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0584086799558062 0.125552192714671 1.0129700898354 0.360655737704918 7.1 7 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.186986046871547 0.310305431240853 1.0111283260357 0.36 7.1 7 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.186986046871547 0.310305431240853 1.0111283260357 0.36 7.1 7 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.119305680461818 0.217935793706248 1.00824761855412 0.358974358974359 7.1 7 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.296169446534698 0.428301953677718 1.00310349805129 0.357142857142857 7.1 7 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.0351890136958175 0.0886264893613243 1.00310349805129 0.357142857142857 7.1 7 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.0351890136958175 0.0886264893613243 1.00310349805129 0.357142857142857 7.1 7 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.113459829425374 0.211881020042397 1.00310349805129 0.357142857142857 7.1 7 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0490005963760922 0.109980833822049 1.00035526928951 0.356164383561644 7.1 7 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.166646096425209 0.287091277497666 0.996631862579993 0.354838709677419 7.1 7 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.157548924889571 0.272077815677015 0.991302280427159 0.352941176470588 7.1 7 1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.274329437440234 0.411783533204065 0.991302280427159 0.352941176470588 7.1 7 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.274329437440234 0.411783533204065 0.991302280427159 0.352941176470588 7.1 7 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.274329437440234 0.411783533204065 0.991302280427159 0.352941176470588 7.1 7 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.274329437440234 0.411783533204065 0.991302280427159 0.352941176470588 7.1 7 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00395793772786614 0.0153047428987867 0.983754293520353 0.350253807106599 7.1 7 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.141166480390272 0.245875032552457 0.983041428090266 0.35 7.1 7 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.255263062388074 0.39482536715025 0.983041428090266 0.35 7.1 7 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.255263062388074 0.39482536715025 0.983041428090266 0.35 7.1 7 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.255263062388074 0.39482536715025 0.983041428090266 0.35 7.1 7 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.255263062388074 0.39482536715025 0.983041428090266 0.35 7.1 7 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.255263062388074 0.39482536715025 0.983041428090266 0.35 7.1 7 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.255263062388074 0.39482536715025 0.983041428090266 0.35 7.1 7 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.255263062388074 0.39482536715025 0.983041428090266 0.35 7.1 7 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.255263062388074 0.39482536715025 0.983041428090266 0.35 7.1 7 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.0730405909715811 0.147219208148102 0.976935580710824 0.347826086956522 7.1 7 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.12684778450209 0.231119586871286 0.976935580710824 0.347826086956522 7.1 7 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.238348882785033 0.377286224916553 0.976935580710824 0.347826086956522 7.1 7 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.0696390441908493 0.142996190308194 0.975239511994312 0.347222222222222 7.1 7 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.223168625574703 0.356819049654835 0.972238775034329 0.346153846153846 7.1 7 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.223168625574703 0.356819049654835 0.972238775034329 0.346153846153846 7.1 7 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.223168625574703 0.356819049654835 0.972238775034329 0.346153846153846 7.1 7 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.223168625574703 0.356819049654835 0.972238775034329 0.346153846153846 7.1 7 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.19689413553696 0.320206119850394 0.965487116874369 0.34375 7.1 7 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.19689413553696 0.320206119850394 0.965487116874369 0.34375 7.1 7 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.19689413553696 0.320206119850394 0.965487116874369 0.34375 7.1 7 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.185407707883845 0.310305431240853 0.96297935812924 0.342857142857143 7.1 7 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0574658036212428 0.125145438859926 0.956149717291444 0.340425531914894 7.1 7 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.14755526312534 0.255750474332959 0.956149717291444 0.340425531914894 7.1 7 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.139696874089646 0.243613543908783 0.95495453014483 0.34 7.1 7 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.132356839027276 0.235429727419768 0.953894647203493 0.339622641509434 7.1 7 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.051728178803676 0.114834942960423 0.944741112710126 0.336363636363636 7.1 7 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0239227056019495 0.0637490825310377 0.942045024256865 0.335403726708075 7.1 7 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00844947019122789 0.0282244039486321 0.940248085727048 0.334763948497854 7.1 7 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0269209845793867 0.070420149000859 0.936229931514539 0.333333333333333 7.1 7 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.116454497530652 0.214336983984063 0.936229931514539 0.333333333333333 7.1 7 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0281487242981592 0.0733619682715761 0.936229931514539 0.333333333333333 7.1 7 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0281487242981592 0.0733619682715761 0.936229931514539 0.333333333333333 7.1 7 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.169987206129983 0.287978755602081 0.936229931514539 0.333333333333333 7.1 7 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.229342875840914 0.365050237496219 0.936229931514539 0.333333333333333 7.1 7 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.244704784500227 0.386047570225968 0.936229931514539 0.333333333333333 7.1 7 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.244704784500227 0.386047570225968 0.936229931514539 0.333333333333333 7.1 7 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.261713469513467 0.398739910430711 0.936229931514539 0.333333333333333 7.1 7 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.280710757525738 0.41398874291747 0.936229931514539 0.333333333333333 7.1 7 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.280710757525738 0.41398874291747 0.936229931514539 0.333333333333333 7.1 7 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.302169637251802 0.435209912762464 0.936229931514539 0.333333333333333 7.1 7 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.302169637251802 0.435209912762464 0.936229931514539 0.333333333333333 7.1 7 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.302169637251802 0.435209912762464 0.936229931514539 0.333333333333333 7.1 7 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.302169637251802 0.435209912762464 0.936229931514539 0.333333333333333 7.1 7 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.326775918482443 0.46453759440611 0.936229931514539 0.333333333333333 7.1 7 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.326775918482443 0.46453759440611 0.936229931514539 0.333333333333333 7.1 7 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.326775918482443 0.46453759440611 0.936229931514539 0.333333333333333 7.1 7 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.155082196877152 0.26814333676329 0.920881899850366 0.327868852459016 7.1 7 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.173171302953807 0.291970099648421 0.919207569123366 0.327272727272727 7.1 7 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.194051959764994 0.316669654524756 0.917123198218324 0.326530612244898 7.1 7 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.205742067093012 0.331563942778433 0.915877106916397 0.326086956521739 7.1 7 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0439137812383417 0.101115389485696 0.913254963870011 0.325153374233129 7.1 7 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0604255200415946 0.12814532789745 0.909857257387369 0.323943661971831 7.1 7 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.281875588345474 0.41398874291747 0.906028965981812 0.32258064516129 7.1 7 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.281875588345474 0.41398874291747 0.906028965981812 0.32258064516129 7.1 7 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.219630823612218 0.35274792550811 0.898780734253957 0.32 7.1 7 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.324816503715946 0.463140165118027 0.898780734253957 0.32 7.1 7 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.112668465555176 0.210679666865987 0.893674025536605 0.318181818181818 7.1 7 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0785838069637176 0.157057243412037 0.887908386662176 0.316129032258064 7.1 7 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.144036071436838 0.250260475768768 0.886954671961142 0.315789473684211 7.1 7 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.232624290723422 0.36985962647981 0.884217157541509 0.314814814814815 7.1 7 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.261667097508711 0.398739910430711 0.87771556079488 0.3125 7.1 7 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.415339613556493 0.561078993282178 0.87771556079488 0.3125 7.1 7 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.415339613556493 0.561078993282178 0.87771556079488 0.3125 7.1 7 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.415339613556493 0.561078993282178 0.87771556079488 0.3125 7.1 7 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.415339613556493 0.561078993282178 0.87771556079488 0.3125 7.1 7 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.278023607953806 0.41398874291747 0.873814602746903 0.311111111111111 7.1 7 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.343817737733712 0.487789272976144 0.871662350030778 0.310344827586207 7.1 7 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.343817737733712 0.487789272976144 0.871662350030778 0.310344827586207 7.1 7 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.295819283714366 0.428301953677718 0.869356364977786 0.30952380952381 7.1 7 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.129770055807529 0.235265794022413 0.867389495373764 0.308823529411765 7.1 7 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.204986148171621 0.330720282140836 0.866879566217166 0.308641975308642 7.1 7 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.315258736002807 0.45360281226693 0.864212244474959 0.307692307692308 7.1 7 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.173989308612261 0.293002113793193 0.864212244474959 0.307692307692308 7.1 7 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.369993338445387 0.51516684990977 0.864212244474959 0.307692307692308 7.1 7 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.135136123038788 0.237336280614008 0.862669008324111 0.307142857142857 7.1 7 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.141416871946138 0.246010035182585 0.861058185188554 0.306569343065693 7.1 7 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.360138584744313 0.502428633422703 0.851118119558672 0.303030303030303 7.1 7 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.360138584744313 0.502428633422703 0.851118119558672 0.303030303030303 7.1 7 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.433930685596684 0.581087534823998 0.842606938363085 0.3 7.1 7 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.433930685596684 0.581087534823998 0.842606938363085 0.3 7.1 7 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.433930685596684 0.581087534823998 0.842606938363085 0.3 7.1 7 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.386294717690921 0.534525091353145 0.842606938363085 0.3 7.1 7 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.386294717690921 0.534525091353145 0.842606938363085 0.3 7.1 7 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.227710410987646 0.362857687385688 0.842606938363085 0.3 7.1 7 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.18813782770113 0.310305431240853 0.840556799826922 0.299270072992701 7.1 7 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.374416659084289 0.520816134777071 0.835015884864319 0.297297297297297 7.1 7 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.415584862206195 0.561078993282178 0.832204383568479 0.296296296296296 7.1 7 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.474093853604934 0.60942687775955 0.826085233689299 0.294117647058824 7.1 7 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.474093853604934 0.60942687775955 0.826085233689299 0.294117647058824 7.1 7 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.474093853604934 0.60942687775955 0.826085233689299 0.294117647058824 7.1 7 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.474093853604934 0.60942687775955 0.826085233689299 0.294117647058824 7.1 7 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.37529895631733 0.521024794965426 0.819201190075222 0.291666666666667 7.1 7 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.37529895631733 0.521024794965426 0.819201190075222 0.291666666666667 7.1 7 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.448709049194057 0.59064148198893 0.819201190075222 0.291666666666667 7.1 7 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00139849356844794 0.00612325030123513 0.817945271874409 0.291219512195122 7.1 7 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.320691620712146 0.459273641607164 0.817719813601306 0.291139240506329 7.1 7 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.364602489321351 0.50815802380439 0.817073394776325 0.290909090909091 7.1 7 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.408819616709534 0.55457608634668 0.802482798441034 0.285714285714286 7.1 7 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.440640640727096 0.588762095544279 0.802482798441034 0.285714285714286 7.1 7 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.486635104934636 0.624983532781577 0.802482798441034 0.285714285714286 7.1 7 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.530754597882816 0.663093760129277 0.780191609595449 0.277777777777778 7.1 7 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.44683768246617 0.59064148198893 0.766006307602805 0.272727272727273 7.1 7 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.543640694899755 0.678597113019607 0.756185713915589 0.269230769230769 7.1 7 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.548992455589516 0.684077289232821 0.748983945211631 0.266666666666667 7.1 7 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.548992455589516 0.684077289232821 0.748983945211631 0.266666666666667 7.1 7 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.499636849196294 0.631423833398159 0.74392324287912 0.264864864864865 7.1 7 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.584477526185928 0.715052192663969 0.739128893300952 0.263157894736842 7.1 7 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.586332635691622 0.715052192663969 0.732701685533118 0.260869565217391 7.1 7 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.590724915188885 0.715052192663969 0.72482317278545 0.258064516129032 7.1 7 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.586381119466022 0.715052192663969 0.72223451859693 0.257142857142857 7.1 7 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.63095530205417 0.752597983925468 0.702172448635904 0.25 7.1 7 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.634659806382343 0.755117813112102 0.702172448635904 0.25 7.1 7 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.632207164524144 0.752829117253436 0.702172448635904 0.25 7.1 7 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.632207164524144 0.752829117253436 0.702172448635904 0.25 7.1 7 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.674939063780193 0.798369316508075 0.674085550690468 0.24 7.1 7 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.713393454425874 0.828025192208824 0.672503190242838 0.23943661971831 7.1 7 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.696660935699411 0.818779359412611 0.668735665367528 0.238095238095238 7.1 7 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.789942424536445 0.894262585612857 0.667920134068299 0.23780487804878 7.1 7 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.699460720784035 0.818779359412611 0.665216003970857 0.236842105263158 7.1 7 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.812975587720566 0.918146239147909 0.664421241719996 0.236559139784946 7.1 7 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.707922791057046 0.822346229938103 0.655360952060177 0.233333333333333 7.1 7 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.750290956759131 0.864126448990484 0.624153287676359 0.222222222222222 7.1 7 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.761034096256812 0.871941641685542 0.610584737944265 0.217391304347826 7.1 7 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.782837044405938 0.887256336622816 0.601862098830775 0.214285714285714 7.1 7 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.794935920396988 0.899200170687531 0.585143707196587 0.208333333333333 7.1 7 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.827295190127493 0.930228878268507 0.578259663582509 0.205882352941176 7.1 7 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.960912842469204 1 0.546134126716814 0.194444444444444 7.1 7 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.861122179572242 0.961834271217661 0.543617379589087 0.193548387096774 7.1 7 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.949121944955868 1 0.533295530609548 0.189873417721519 7.1 7 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999919388885579 1 0.51396127683659 0.182989690721649 7.1 7 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.958803685576694 1 0.46811496575727 0.166666666666667 7.1 7 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.93823012596139 1 0.453014482990906 0.161290322580645 7.1 7 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.93823012596139 1 0.453014482990906 0.161290322580645 7.1 7 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.99998384039453 1 0.451396574123081 0.160714285714286 7.1 7 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.99465510551559 1 0.436907301373452 0.155555555555556 7.1 7 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999993349320461 1 0.401241399220517 0.142857142857143 7.1 7 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.398546242886542 0.141897565071369 7.1 7 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.993282696019685 1 0.370959029468025 0.132075471698113 7.1 7 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999997564332054 1 0.351086224317952 0.125 7.1 7 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.319977318365729 0.113924050632911 7.1 7 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0226507241495453 0.00806451612903226 7.1 7 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 2.9857105062153e-06 1.37943702933259e-05 1.48036850186444 1 7.2 7 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 1.83888346367023e-05 7.24856279446741e-05 1.48036850186444 1 7.2 7 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 4.56329978804687e-05 0.000167792651121206 1.48036850186444 1 7.2 7 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00172977044917389 0.00455826546143416 1.48036850186444 1 7.2 7 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00172977044917389 0.00455826546143416 1.48036850186444 1 7.2 7 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00172977044917389 0.00455826546143416 1.48036850186444 1 7.2 7 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.00172977044917389 0.00455826546143416 1.48036850186444 1 7.2 7 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.00429159198998465 0.0100443016476121 1.48036850186444 1 7.2 7 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.00429159198998465 0.0100443016476121 1.48036850186444 1 7.2 7 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00429159198998465 0.0100443016476121 1.48036850186444 1 7.2 7 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00429159198998465 0.0100443016476121 1.48036850186444 1 7.2 7 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.000113236078884775 0.000388276964465143 1.48036850186444 1 7.2 7 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000113236078884775 0.000388276964465143 1.48036850186444 1 7.2 7 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000113236078884775 0.000388276964465143 1.48036850186444 1 7.2 7 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000280977583799907 0.000897797959763098 1.48036850186444 1 7.2 7 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000280977583799907 0.000897797959763098 1.48036850186444 1 7.2 7 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000280977583799907 0.000897797959763098 1.48036850186444 1 7.2 7 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.000697171390164434 0.00201232228844623 1.48036850186444 1 7.2 7 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000697171390164434 0.00201232228844623 1.48036850186444 1 7.2 7 2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%REACT_198714.2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_216520.1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605079 POLO-LIKE KINASE MEDIATED EVENTS 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0106470530067502 0.0224455650794157 1.48036850186444 1 7.2 7 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 5.15271502148916e-09 3.64791715202939e-08 1.42115376178987 0.96 7.2 7 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 9.24266830815357e-07 4.66394219946898e-06 1.40245437018737 0.947368421052632 7.2 7 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 1.19776450804675e-05 4.81474264110317e-05 1.38784547049792 0.9375 7.2 7 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 1.19776450804675e-05 4.81474264110317e-05 1.38784547049792 0.9375 7.2 7 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 1.19776450804675e-05 4.81474264110317e-05 1.38784547049792 0.9375 7.2 7 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.4369799846009e-09 1.14877669555454e-08 1.38167726840681 0.933333333333333 7.2 7 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 6.49239078620979e-05 0.000229817713651157 1.37462789458841 0.928571428571429 7.2 7 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 6.49239078620979e-05 0.000229817713651157 1.37462789458841 0.928571428571429 7.2 7 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.000150136440754647 0.000498005023761917 1.36649400172103 0.923076923076923 7.2 7 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000150136440754647 0.000498005023761917 1.36649400172103 0.923076923076923 7.2 7 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.16202507724333e-07 1.17426018508292e-06 1.35700446004241 0.916666666666667 7.2 7 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000345318793561899 0.00106591896581037 1.35700446004241 0.916666666666667 7.2 7 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000345318793561899 0.00106591896581037 1.35700446004241 0.916666666666667 7.2 7 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000345318793561899 0.00106591896581037 1.35700446004241 0.916666666666667 7.2 7 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.000345318793561899 0.00106591896581037 1.35700446004241 0.916666666666667 7.2 7 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.000345318793561899 0.00106591896581037 1.35700446004241 0.916666666666667 7.2 7 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.000345318793561899 0.00106591896581037 1.35700446004241 0.916666666666667 7.2 7 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000345318793561899 0.00106591896581037 1.35700446004241 0.916666666666667 7.2 7 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 1.12134513932787e-06 5.57928018623622e-06 1.34578954714949 0.909090909090909 7.2 7 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.000789266888927833 0.00225075507604069 1.34578954714949 0.909090909090909 7.2 7 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.000789266888927833 0.00225075507604069 1.34578954714949 0.909090909090909 7.2 7 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.000789266888927833 0.00225075507604069 1.34578954714949 0.909090909090909 7.2 7 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000789266888927833 0.00225075507604069 1.34578954714949 0.909090909090909 7.2 7 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.000789266888927833 0.00225075507604069 1.34578954714949 0.909090909090909 7.2 7 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 2.53855264696045e-06 1.19219815730189e-05 1.3393810254964 0.904761904761905 7.2 7 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 2.53855264696045e-06 1.19219815730189e-05 1.3393810254964 0.904761904761905 7.2 7 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.31030584607041e-13 2.58967391521972e-12 1.33523433501499 0.901960784313726 7.2 7 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.31030584607041e-13 2.58967391521972e-12 1.33523433501499 0.901960784313726 7.2 7 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 5.72118867795369e-06 2.38048289144097e-05 1.332331651678 0.9 7.2 7 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0017906511280361 0.0046161169478177 1.332331651678 0.9 7.2 7 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.47277950886405e-12 2.3030387264984e-11 1.3261634495869 0.895833333333333 7.2 7 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 1.28305358811247e-05 5.1286102693372e-05 1.32454023851029 0.894736842105263 7.2 7 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 1.28305358811247e-05 5.1286102693372e-05 1.32454023851029 0.894736842105263 7.2 7 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00402672184108066 0.00963029441992903 1.31588311276839 0.888888888888889 7.2 7 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00402672184108066 0.00963029441992903 1.31588311276839 0.888888888888889 7.2 7 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00402672184108066 0.00963029441992903 1.31588311276839 0.888888888888889 7.2 7 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00402672184108066 0.00963029441992903 1.31588311276839 0.888888888888889 7.2 7 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.00402672184108066 0.00963029441992903 1.31588311276839 0.888888888888889 7.2 7 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00402672184108066 0.00963029441992903 1.31588311276839 0.888888888888889 7.2 7 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.62098780697776e-11 1.92222137444113e-10 1.31588311276839 0.888888888888889 7.2 7 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 3.58719316959652e-11 4.05125069867924e-10 1.31214480847076 0.886363636363636 7.2 7 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 6.34447784549075e-05 0.000225704799353334 1.3062075016451 0.882352941176471 7.2 7 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 6.34447784549075e-05 0.000225704799353334 1.3062075016451 0.882352941176471 7.2 7 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 6.34447784549075e-05 0.000225704799353334 1.3062075016451 0.882352941176471 7.2 7 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 3.8213091952417e-10 3.31568474684692e-09 1.29983575773463 0.878048780487805 7.2 7 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 3.8213091952417e-10 3.31568474684692e-09 1.29983575773463 0.878048780487805 7.2 7 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 2.433016464058e-06 1.15022672038357e-05 1.29532243913139 0.875 7.2 7 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000139705637355994 0.000466669300369906 1.29532243913139 0.875 7.2 7 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000139705637355994 0.000466669300369906 1.29532243913139 0.875 7.2 7 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000139705637355994 0.000466669300369906 1.29532243913139 0.875 7.2 7 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.000139705637355994 0.000466669300369906 1.29532243913139 0.875 7.2 7 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0089579638622401 0.0194316807560483 1.29532243913139 0.875 7.2 7 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 3.47850639579565e-11 3.95993168097377e-10 1.29138528886047 0.872340425531915 7.2 7 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00030529562221883 0.000965412600927545 1.28298603494918 0.866666666666667 7.2 7 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.00030529562221883 0.000965412600927545 1.28298603494918 0.866666666666667 7.2 7 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00030529562221883 0.000965412600927545 1.28298603494918 0.866666666666667 7.2 7 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 1.15142001953e-05 4.66800765752476e-05 1.27850006979202 0.863636363636364 7.2 7 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 1.15142001953e-05 4.66800765752476e-05 1.27850006979202 0.863636363636364 7.2 7 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 4.54776226541552e-07 2.37921533223761e-06 1.27617974298659 0.862068965517241 7.2 7 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 1.84392021884448e-08 1.10713015671549e-07 1.27476176549438 0.861111111111111 7.2 7 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 1.84392021884448e-08 1.10713015671549e-07 1.27476176549438 0.861111111111111 7.2 7 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.84392021884448e-08 1.10713015671549e-07 1.27476176549438 0.861111111111111 7.2 7 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 1.84392021884448e-08 1.10713015671549e-07 1.27476176549438 0.861111111111111 7.2 7 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 9.77555774860079e-07 4.88091883377506e-06 1.26888728731238 0.857142857142857 7.2 7 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 9.77555774860079e-07 4.88091883377506e-06 1.26888728731238 0.857142857142857 7.2 7 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 2.48170048639131e-05 9.5963581308012e-05 1.26888728731238 0.857142857142857 7.2 7 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 2.48170048639131e-05 9.5963581308012e-05 1.26888728731238 0.857142857142857 7.2 7 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 2.48170048639131e-05 9.5963581308012e-05 1.26888728731238 0.857142857142857 7.2 7 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00066141163810994 0.00193262579267032 1.26888728731238 0.857142857142857 7.2 7 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00066141163810994 0.00193262579267032 1.26888728731238 0.857142857142857 7.2 7 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0196625212348492 0.0382760160289882 1.26888728731238 0.857142857142857 7.2 7 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.48089842872797e-09 2.52720329799995e-08 1.26372920890867 0.853658536585366 7.2 7 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.48089842872797e-09 2.52720329799995e-08 1.26372920890867 0.853658536585366 7.2 7 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.08995416590017e-06 9.91334926025313e-06 1.26105464973638 0.851851851851852 7.2 7 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 2.08995416590017e-06 9.91334926025313e-06 1.26105464973638 0.851851851851852 7.2 7 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 2.08995416590017e-06 9.91334926025313e-06 1.26105464973638 0.851851851851852 7.2 7 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 2.08995416590017e-06 9.91334926025313e-06 1.26105464973638 0.851851851851852 7.2 7 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.95332508397998e-14 1.13686799911347e-12 1.25941797919811 0.850746268656716 7.2 7 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 7.40549723197878e-09 5.16569733387539e-08 1.25831322658478 0.85 7.2 7 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.31168366990934e-05 0.000192328902348117 1.25831322658478 0.85 7.2 7 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 5.31168366990934e-05 0.000192328902348117 1.25831322658478 0.85 7.2 7 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 5.31168366990934e-05 0.000192328902348117 1.25831322658478 0.85 7.2 7 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 4.44226106746919e-06 1.89261601766726e-05 1.25261950157761 0.846153846153846 7.2 7 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 4.44226106746919e-06 1.89261601766726e-05 1.25261950157761 0.846153846153846 7.2 7 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 4.44226106746919e-06 1.89261601766726e-05 1.25261950157761 0.846153846153846 7.2 7 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 4.44226106746919e-06 1.89261601766726e-05 1.25261950157761 0.846153846153846 7.2 7 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00141882173400179 0.00381660364363808 1.25261950157761 0.846153846153846 7.2 7 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00141882173400179 0.00381660364363808 1.25261950157761 0.846153846153846 7.2 7 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00141882173400179 0.00381660364363808 1.25261950157761 0.846153846153846 7.2 7 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00141882173400179 0.00381660364363808 1.25261950157761 0.846153846153846 7.2 7 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00141882173400179 0.00381660364363808 1.25261950157761 0.846153846153846 7.2 7 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000112816410211937 0.000388276964465143 1.24662610683322 0.842105263157895 7.2 7 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000112816410211937 0.000388276964465143 1.24662610683322 0.842105263157895 7.2 7 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 9.83575787885623e-13 1.62747482111772e-11 1.24538937458437 0.841269841269841 7.2 7 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.91078696120489e-09 2.15549498251847e-08 1.24485533111328 0.840909090909091 7.2 7 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.91078696120489e-09 2.15549498251847e-08 1.24485533111328 0.840909090909091 7.2 7 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 7.98903003136011e-15 2.06697995175008e-13 1.24350954156613 0.84 7.2 7 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 7.98903003136011e-15 2.06697995175008e-13 1.24350954156613 0.84 7.2 7 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 7.98903003136011e-15 2.06697995175008e-13 1.24350954156613 0.84 7.2 7 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 7.98903003136011e-15 2.06697995175008e-13 1.24350954156613 0.84 7.2 7 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 7.98903003136011e-15 2.06697995175008e-13 1.24350954156613 0.84 7.2 7 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.06180598985416e-12 3.15478486404567e-11 1.2415993886605 0.838709677419355 7.2 7 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 8.00835325410436e-07 4.08454719734427e-06 1.2415993886605 0.838709677419355 7.2 7 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 6.95006220183146e-08 3.94021454709409e-07 1.24030874480534 0.837837837837838 7.2 7 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.51164323526317e-15 5.00248447390581e-14 1.23980862031147 0.8375 7.2 7 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 5.40213964979886e-10 4.63087031425529e-09 1.23867568523351 0.836734693877551 7.2 7 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 1.96846239981505e-05 7.69539009598026e-05 1.23364041822037 0.833333333333333 7.2 7 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 1.96846239981505e-05 7.69539009598026e-05 1.23364041822037 0.833333333333333 7.2 7 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 1.96846239981505e-05 7.69539009598026e-05 1.23364041822037 0.833333333333333 7.2 7 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00300900736575751 0.00729440797525203 1.23364041822037 0.833333333333333 7.2 7 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00300900736575751 0.00729440797525203 1.23364041822037 0.833333333333333 7.2 7 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.00300900736575751 0.00729440797525203 1.23364041822037 0.833333333333333 7.2 7 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00300900736575751 0.00729440797525203 1.23364041822037 0.833333333333333 7.2 7 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00300900736575751 0.00729440797525203 1.23364041822037 0.833333333333333 7.2 7 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00300900736575751 0.00729440797525203 1.23364041822037 0.833333333333333 7.2 7 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%REACT_196647.2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1) 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%REACT_198612.2 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 0.0424243580905782 0.0741644490944629 1.23364041822037 0.833333333333333 7.2 7 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 5.39195722416294e-17 2.19221575142396e-15 1.23364041822037 0.833333333333333 7.2 7 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 8.97823552915163e-12 1.14201304630545e-10 1.23364041822037 0.833333333333333 7.2 7 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 8.97823552915163e-12 1.14201304630545e-10 1.23364041822037 0.833333333333333 7.2 7 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 8.97823552915163e-12 1.14201304630545e-10 1.23364041822037 0.833333333333333 7.2 7 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 8.97823552915163e-12 1.14201304630545e-10 1.23364041822037 0.833333333333333 7.2 7 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 8.97823552915163e-12 1.14201304630545e-10 1.23364041822037 0.833333333333333 7.2 7 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 8.97823552915163e-12 1.14201304630545e-10 1.23364041822037 0.833333333333333 7.2 7 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 8.97823552915163e-12 1.14201304630545e-10 1.23364041822037 0.833333333333333 7.2 7 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 1.27365949658992e-08 7.88007592890198e-08 1.23364041822037 0.833333333333333 7.2 7 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.67612312739769e-06 8.08516342470141e-06 1.23364041822037 0.833333333333333 7.2 7 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000237579774746867 0.000768354589692707 1.23364041822037 0.833333333333333 7.2 7 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000237579774746867 0.000768354589692707 1.23364041822037 0.833333333333333 7.2 7 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.58414451126696e-29 7.70874117109492e-27 1.23055631717482 0.83125 7.2 7 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 3.01939232808208e-07 1.61526138453414e-06 1.22659104440197 0.828571428571429 7.2 7 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 3.48689760678902e-06 1.58525728257533e-05 1.22513255326713 0.827586206896552 7.2 7 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 3.48689760678902e-06 1.58525728257533e-05 1.22513255326713 0.827586206896552 7.2 7 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 3.48689760678902e-06 1.58525728257533e-05 1.22513255326713 0.827586206896552 7.2 7 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 4.84299134651311e-09 3.46310386235586e-08 1.22291311023585 0.826086956521739 7.2 7 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 4.09923002875431e-05 0.000152701684055429 1.22291311023585 0.826086956521739 7.2 7 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 4.09923002875431e-05 0.000152701684055429 1.22291311023585 0.826086956521739 7.2 7 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 8.89100271018423e-10 7.27120508999549e-09 1.21912700153542 0.823529411764706 7.2 7 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000495589645561063 0.00147845716065701 1.21912700153542 0.823529411764706 7.2 7 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000495589645561063 0.00147845716065701 1.21912700153542 0.823529411764706 7.2 7 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000495589645561063 0.00147845716065701 1.21912700153542 0.823529411764706 7.2 7 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000495589645561063 0.00147845716065701 1.21912700153542 0.823529411764706 7.2 7 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000495589645561063 0.00147845716065701 1.21912700153542 0.823529411764706 7.2 7 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 7.20698676468457e-06 2.9640295277879e-05 1.21601698367436 0.821428571428571 7.2 7 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 7.20698676468457e-06 2.9640295277879e-05 1.21601698367436 0.821428571428571 7.2 7 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 2.72866694926803e-12 4.08725586190358e-11 1.21522787466484 0.82089552238806 7.2 7 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 5.06203204458221e-13 9.23496358902627e-12 1.21307974458336 0.819444444444444 7.2 7 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 8.46796258726721e-05 0.000295340950041207 1.21121059243455 0.818181818181818 7.2 7 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 8.46796258726721e-05 0.000295340950041207 1.21121059243455 0.818181818181818 7.2 7 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 8.46796258726721e-05 0.000295340950041207 1.21121059243455 0.818181818181818 7.2 7 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00629688020402329 0.0142229532227383 1.21121059243455 0.818181818181818 7.2 7 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00629688020402329 0.0142229532227383 1.21121059243455 0.818181818181818 7.2 7 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.00629688020402329 0.0142229532227383 1.21121059243455 0.818181818181818 7.2 7 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00629688020402329 0.0142229532227383 1.21121059243455 0.818181818181818 7.2 7 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00629688020402329 0.0142229532227383 1.21121059243455 0.818181818181818 7.2 7 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.00629688020402329 0.0142229532227383 1.21121059243455 0.818181818181818 7.2 7 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.28347911974376e-06 6.28407582571597e-06 1.21121059243454 0.818181818181818 7.2 7 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 1.28347911974376e-06 6.28407582571597e-06 1.21121059243454 0.818181818181818 7.2 7 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 1.28347911974376e-06 6.28407582571597e-06 1.21121059243454 0.818181818181818 7.2 7 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 6.83868012123209e-10 5.72437753677251e-09 1.20622618670436 0.814814814814815 7.2 7 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.62241255008137e-06 1.22350592090682e-05 1.20279940776486 0.8125 7.2 7 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00102285222329112 0.00283726844784262 1.20279940776486 0.8125 7.2 7 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00102285222329112 0.00283726844784262 1.20279940776486 0.8125 7.2 7 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00102285222329112 0.00283726844784262 1.20279940776486 0.8125 7.2 7 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00102285222329112 0.00283726844784262 1.20279940776486 0.8125 7.2 7 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00102285222329112 0.00283726844784262 1.20279940776486 0.8125 7.2 7 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00102285222329112 0.00283726844784262 1.20279940776486 0.8125 7.2 7 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00102285222329112 0.00283726844784262 1.20279940776486 0.8125 7.2 7 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.27440671272864e-12 6.08248075221286e-11 1.2014584942668 0.811594202898551 7.2 7 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.27440671272864e-12 6.08248075221286e-11 1.2014584942668 0.811594202898551 7.2 7 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 4.69805925692868e-07 2.43103211731255e-06 1.2002987852955 0.810810810810811 7.2 7 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 4.69805925692868e-07 2.43103211731255e-06 1.2002987852955 0.810810810810811 7.2 7 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.54923228701347e-10 2.29592249646846e-09 1.19960895840739 0.810344827586207 7.2 7 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.54923228701347e-10 2.29592249646846e-09 1.19960895840739 0.810344827586207 7.2 7 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.54923228701347e-10 2.29592249646846e-09 1.19960895840739 0.810344827586207 7.2 7 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.46464520017985e-13 2.85505495870675e-12 1.19928587492816 0.810126582278481 7.2 7 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00017339112199861 0.000565907262853262 1.19839354912836 0.80952380952381 7.2 7 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.54079131278483e-08 9.45062947453798e-08 1.19689368235849 0.808510638297872 7.2 7 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 3.6268175006729e-21 1.98498511671444e-19 1.1956822515059 0.807692307692308 7.2 7 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 3.01342204360471e-05 0.000113742694112719 1.1956822515059 0.807692307692308 7.2 7 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 3.01342204360471e-05 0.000113742694112719 1.1956822515059 0.807692307692308 7.2 7 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 3.01342204360471e-05 0.000113742694112719 1.1956822515059 0.807692307692308 7.2 7 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 3.01342204360471e-05 0.000113742694112719 1.1956822515059 0.807692307692308 7.2 7 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 5.34265064409197e-27 4.47211286267228e-25 1.19300285150252 0.805882352941176 7.2 7 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 3.22049628064787e-12 4.72450124470301e-11 1.19251907094636 0.805555555555556 7.2 7 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 1.71391333368365e-07 9.38037951473781e-07 1.19151611125675 0.804878048780488 7.2 7 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 1.71391333368365e-07 9.38037951473781e-07 1.19151611125675 0.804878048780488 7.2 7 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 1.71391333368365e-07 9.38037951473781e-07 1.19151611125675 0.804878048780488 7.2 7 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 1.71391333368365e-07 9.38037951473781e-07 1.19151611125675 0.804878048780488 7.2 7 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.07477135158808e-26 8.49666462949906e-25 1.19130246303884 0.804733727810651 7.2 7 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 3.10833447268702e-08 1.83533608076084e-07 1.19073118628227 0.804347826086957 7.2 7 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.15694083151526e-25 8.2316340162311e-24 1.18974401070087 0.803680981595092 7.2 7 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 1.90397281124327e-10 1.74796987767689e-09 1.18914846871078 0.80327868852459 7.2 7 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.9489211022511e-20 1.49868383160833e-18 1.18895737945018 0.803149606299213 7.2 7 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.21445245987196e-13 4.20155446719706e-12 1.18795003236036 0.802469135802469 7.2 7 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.21445245987196e-13 4.20155446719706e-12 1.18795003236036 0.802469135802469 7.2 7 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 8.21404511267801e-14 1.74456510378221e-12 1.18429480149156 0.8 7.2 7 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 8.21404511267801e-14 1.74456510378221e-12 1.18429480149156 0.8 7.2 7 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 2.07851008327193e-09 1.59017196155696e-08 1.18429480149156 0.8 7.2 7 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.07851008327193e-09 1.59017196155696e-08 1.18429480149156 0.8 7.2 7 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 2.07851008327193e-09 1.59017196155696e-08 1.18429480149156 0.8 7.2 7 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 2.07851008327193e-09 1.59017196155696e-08 1.18429480149156 0.8 7.2 7 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 2.07851008327193e-09 1.59017196155696e-08 1.18429480149156 0.8 7.2 7 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 4.739871244056e-32 5.62069731690974e-30 1.18429480149156 0.8 7.2 7 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 5.26671001663438e-16 1.82793374479774e-14 1.18429480149156 0.8 7.2 7 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.39340034325694e-12 3.62320073239853e-11 1.18429480149156 0.8 7.2 7 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.29496123982746e-11 1.54851247418023e-10 1.18429480149156 0.8 7.2 7 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 3.81451573542587e-10 3.31568474684692e-09 1.18429480149156 0.8 7.2 7 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.13643720936488e-08 7.09276381107994e-08 1.18429480149156 0.8 7.2 7 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 6.08910300527383e-05 0.000218256765151251 1.18429480149156 0.8 7.2 7 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 6.08910300527383e-05 0.000218256765151251 1.18429480149156 0.8 7.2 7 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 6.08910300527383e-05 0.000218256765151251 1.18429480149156 0.8 7.2 7 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.000351614704263313 0.00107140840292654 1.18429480149156 0.8 7.2 7 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000351614704263313 0.00107140840292654 1.18429480149156 0.8 7.2 7 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.000351614704263313 0.00107140840292654 1.18429480149156 0.8 7.2 7 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000351614704263313 0.00107140840292654 1.18429480149156 0.8 7.2 7 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.000351614704263313 0.00107140840292654 1.18429480149156 0.8 7.2 7 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000351614704263313 0.00107140840292654 1.18429480149156 0.8 7.2 7 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00208587570167439 0.00528149666100116 1.18429480149156 0.8 7.2 7 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0129710046932588 0.0266730342174961 1.18429480149156 0.8 7.2 7 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 8.83871755448281e-13 1.47970530353283e-11 1.1805470331324 0.79746835443038 7.2 7 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 8.83871755448281e-13 1.47970530353283e-11 1.1805470331324 0.79746835443038 7.2 7 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.4006805993514e-10 1.35895802913129e-09 1.17966864992323 0.796875 7.2 7 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 7.61194056797295e-10 6.29755315594506e-09 1.17927660318015 0.796610169491525 7.2 7 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 7.61194056797295e-10 6.29755315594506e-09 1.17927660318015 0.796610169491525 7.2 7 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.09058015589854e-15 6.76112627691732e-14 1.17825248107578 0.795918367346939 7.2 7 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 9.4934115687876e-12 1.19549775773316e-10 1.17618319326216 0.794520547945205 7.2 7 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 3.825944032463e-06 1.72835503434757e-05 1.17558675148059 0.794117647058823 7.2 7 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.78408605185616e-10 2.49166946653542e-09 1.17489563640035 0.793650793650794 7.2 7 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 1.51274494862631e-09 1.20258997871242e-08 1.17408536354766 0.793103448275862 7.2 7 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 8.2429618338246e-09 5.69404596579243e-08 1.17312220902465 0.792452830188679 7.2 7 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000121961470187236 0.000413098459482196 1.17195839730935 0.791666666666667 7.2 7 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.000121961470187236 0.000413098459482196 1.17195839730935 0.791666666666667 7.2 7 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000705442391752847 0.00203207393413826 1.16871197515614 0.789473684210526 7.2 7 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 3.71452378575915e-11 4.16202153317738e-10 1.16761459301984 0.788732394366197 7.2 7 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 7.59559386276387e-06 3.11485016331786e-05 1.1663509408629 0.787878787878788 7.2 7 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.08688280708693e-09 8.73804652251243e-09 1.16488013261464 0.786885245901639 7.2 7 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.08688280708693e-09 8.73804652251243e-09 1.16488013261464 0.786885245901639 7.2 7 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 5.89765820384209e-09 4.13417124338291e-08 1.16314668003635 0.785714285714286 7.2 7 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.89765820384209e-09 4.13417124338291e-08 1.16314668003635 0.785714285714286 7.2 7 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 4.260563522323e-05 0.000157474854344562 1.16314668003635 0.785714285714286 7.2 7 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 4.260563522323e-05 0.000157474854344562 1.16314668003635 0.785714285714286 7.2 7 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 4.260563522323e-05 0.000157474854344562 1.16314668003635 0.785714285714286 7.2 7 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00419599208560521 0.00988559062552353 1.16314668003635 0.785714285714286 7.2 7 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00419599208560521 0.00988559062552353 1.16314668003635 0.785714285714286 7.2 7 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00419599208560521 0.00988559062552353 1.16314668003635 0.785714285714286 7.2 7 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00419599208560521 0.00988559062552353 1.16314668003635 0.785714285714286 7.2 7 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00419599208560521 0.00988559062552353 1.16314668003635 0.785714285714286 7.2 7 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00419599208560521 0.00988559062552353 1.16314668003635 0.785714285714286 7.2 7 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00419599208560521 0.00988559062552353 1.16314668003635 0.785714285714286 7.2 7 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00419599208560521 0.00988559062552353 1.16314668003635 0.785714285714286 7.2 7 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 3.20865148028029e-08 1.88674010596647e-07 1.16107333479564 0.784313725490196 7.2 7 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.13410918856429e-09 1.62397720605721e-08 1.15962199312715 0.783333333333333 7.2 7 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.43249265193038e-10 1.35895802913129e-09 1.1585492623287 0.782608695652174 7.2 7 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000241953997979137 0.000778960495756363 1.1585492623287 0.782608695652174 7.2 7 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.000241953997979137 0.000778960495756363 1.1585492623287 0.782608695652174 7.2 7 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 1.15658745907967e-08 7.18700416711951e-08 1.15737901054857 0.781818181818182 7.2 7 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 6.57269904480722e-13 1.15468527663712e-11 1.15706963364117 0.781609195402299 7.2 7 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 6.57269904480722e-13 1.15468527663712e-11 1.15706963364117 0.781609195402299 7.2 7 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 7.72481981080167e-10 6.35399918541663e-09 1.1565378920816 0.78125 7.2 7 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 5.20076113393639e-11 5.69283314891652e-10 1.15590417268868 0.780821917808219 7.2 7 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 5.20076113393639e-11 5.69283314891652e-10 1.15590417268868 0.780821917808219 7.2 7 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.09697941163796e-16 7.65128641733542e-15 1.15572628654329 0.780701754385965 7.2 7 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 3.52196094478914e-12 5.11403104534178e-11 1.15540956243079 0.780487804878049 7.2 7 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 9.5957195336002e-07 4.824985475729e-06 1.15540956243079 0.780487804878049 7.2 7 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.17207887355978e-09 3.01363869902313e-08 1.15418561162313 0.779661016949153 7.2 7 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.28140591504012e-12 2.09590875528976e-11 1.15331034447579 0.779069767441861 7.2 7 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.18040726305585e-14 7.41921235299749e-13 1.15139772367235 0.777777777777778 7.2 7 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 1.01312997167688e-10 1.08397289450842e-09 1.15139772367235 0.777777777777778 7.2 7 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.01312997167688e-10 1.08397289450842e-09 1.15139772367235 0.777777777777778 7.2 7 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00139862419341076 0.00379817218935785 1.15139772367235 0.777777777777778 7.2 7 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00139862419341076 0.00379817218935785 1.15139772367235 0.777777777777778 7.2 7 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00139862419341076 0.00379817218935785 1.15139772367235 0.777777777777778 7.2 7 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00139862419341076 0.00379817218935785 1.15139772367235 0.777777777777778 7.2 7 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00139862419341076 0.00379817218935785 1.15139772367235 0.777777777777778 7.2 7 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00139862419341076 0.00379817218935785 1.15139772367235 0.777777777777778 7.2 7 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0262173109362982 0.0487497023120349 1.15139772367235 0.777777777777778 7.2 7 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.257364642774e-08 1.34402924128343e-07 1.15139772367235 0.777777777777778 7.2 7 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 2.257364642774e-08 1.34402924128343e-07 1.15139772367235 0.777777777777778 7.2 7 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 8.38305519419073e-05 0.000294545371390948 1.15139772367235 0.777777777777778 7.2 7 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 8.38305519419073e-05 0.000294545371390948 1.15139772367235 0.777777777777778 7.2 7 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.39748470732477e-56 8.52905184630787e-54 1.15023937586181 0.776995305164319 7.2 7 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 1.87190645394899e-06 8.99906379719395e-06 1.14728558894494 0.775 7.2 7 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 2.92347527495478e-09 2.15549498251847e-08 1.14609174337892 0.774193548387097 7.2 7 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 2.92677322855309e-05 0.000111656790998152 1.14609174337892 0.774193548387097 7.2 7 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.90343818350952e-34 2.70859253513404e-32 1.14572581370352 0.773946360153257 7.2 7 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 4.82365868727347e-12 6.60006376152899e-11 1.14552324549034 0.773809523809524 7.2 7 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 4.82365868727347e-12 6.60006376152899e-11 1.14552324549034 0.773809523809524 7.2 7 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 4.38395163865165e-08 2.55670622204971e-07 1.1451907278574 0.773584905660377 7.2 7 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000475010208826798 0.00143207526940791 1.14392111507707 0.772727272727273 7.2 7 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000475010208826798 0.00143207526940791 1.14392111507707 0.772727272727273 7.2 7 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 2.57254465544116e-11 3.00059921696128e-10 1.1430693495409 0.772151898734177 7.2 7 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.84082842014102e-38 1.03893735523258e-35 1.14185420280329 0.771331058020478 7.2 7 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.20251718236125e-29 3.50552457730774e-27 1.14180888933042 0.771300448430493 7.2 7 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 2.37118526844394e-07 1.28296450075883e-06 1.14111738685384 0.770833333333333 7.2 7 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 5.72673123677727e-15 1.66308949998654e-13 1.14083444180379 0.770642201834862 7.2 7 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.37200979867595e-10 1.35895802913129e-09 1.14028384603072 0.77027027027027 7.2 7 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.37200979867595e-10 1.35895802913129e-09 1.14028384603072 0.77027027027027 7.2 7 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 8.35513577582141e-14 1.74843503073439e-12 1.13988374643562 0.77 7.2 7 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 2.03214243259891e-09 1.59017196155696e-08 1.13874500143419 0.769230769230769 7.2 7 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.000163413728775042 0.000535801235131069 1.13874500143419 0.769230769230769 7.2 7 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.000163413728775042 0.000535801235131069 1.13874500143419 0.769230769230769 7.2 7 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000163413728775042 0.000535801235131069 1.13874500143419 0.769230769230769 7.2 7 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00830962613827659 0.0183327100694071 1.13874500143419 0.769230769230769 7.2 7 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00830962613827659 0.0183327100694071 1.13874500143419 0.769230769230769 7.2 7 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.00830962613827659 0.0183327100694071 1.13874500143419 0.769230769230769 7.2 7 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00830962613827659 0.0183327100694071 1.13874500143419 0.769230769230769 7.2 7 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.00830962613827659 0.0183327100694071 1.13874500143419 0.769230769230769 7.2 7 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00830962613827659 0.0183327100694071 1.13874500143419 0.769230769230769 7.2 7 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00830962613827659 0.0183327100694071 1.13874500143419 0.769230769230769 7.2 7 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.00830962613827659 0.0183327100694071 1.13874500143419 0.769230769230769 7.2 7 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.63272918143072e-17 1.52040400740468e-15 1.13609675724481 0.767441860465116 7.2 7 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.28507805009371e-06 6.28407582571597e-06 1.13609675724481 0.767441860465116 7.2 7 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.11087168302065e-14 5.17891449127307e-13 1.13448801077462 0.766355140186916 7.2 7 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.11087168302065e-14 5.17891449127307e-13 1.13448801077462 0.766355140186916 7.2 7 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.91494438653316e-16 7.1709627948334e-15 1.13415328771873 0.766129032258065 7.2 7 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.91494438653316e-16 7.1709627948334e-15 1.13415328771873 0.766129032258065 7.2 7 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.91494438653316e-16 7.1709627948334e-15 1.13415328771873 0.766129032258065 7.2 7 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 4.56725463295555e-07 2.38066056509002e-06 1.13389927802383 0.765957446808511 7.2 7 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.92726648202464e-23 1.2465910017823e-21 1.13252235115313 0.765027322404372 7.2 7 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.2407237333158e-11 1.49622870551558e-10 1.13204650142575 0.764705882352941 7.2 7 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.2407237333158e-11 1.49622870551558e-10 1.13204650142575 0.764705882352941 7.2 7 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.2407237333158e-11 1.49622870551558e-10 1.13204650142575 0.764705882352941 7.2 7 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.98469558112417e-05 7.73759400531425e-05 1.13204650142575 0.764705882352941 7.2 7 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00273645560091379 0.00670219676437232 1.13204650142575 0.764705882352941 7.2 7 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.00273645560091379 0.00670219676437232 1.13204650142575 0.764705882352941 7.2 7 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.00273645560091379 0.00670219676437232 1.13204650142575 0.764705882352941 7.2 7 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00273645560091379 0.00670219676437232 1.13204650142575 0.764705882352941 7.2 7 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.00273645560091379 0.00670219676437232 1.13204650142575 0.764705882352941 7.2 7 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.27144653460263e-64 6.0308947291318e-62 1.13138429229944 0.76425855513308 7.2 7 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.04936942772045e-10 4.35469860342194e-09 1.13083705003534 0.763888888888889 7.2 7 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.62204926625034e-12 2.50888707160244e-11 1.13017380249866 0.763440860215054 7.2 7 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 1.8192166703499e-10 1.68100345578436e-09 1.1297549093176 0.763157894736842 7.2 7 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 7.73808205761528e-28 6.88205672999159e-26 1.12853204178007 0.762331838565022 7.2 7 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.000921930167510364 0.00261335981746464 1.12789981094434 0.761904761904762 7.2 7 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 7.45934847588197e-09 5.17787945423417e-08 1.12789981094434 0.761904761904762 7.2 7 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 2.67815852854758e-09 2.01641247943027e-08 1.12684766559831 0.761194029850746 7.2 7 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 2.67815852854758e-09 2.01641247943027e-08 1.12684766559831 0.761194029850746 7.2 7 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.11474322680485e-33 2.73570873794845e-31 1.1266039701689 0.761029411764706 7.2 7 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 8.74438082181567e-07 4.42820423823619e-06 1.12636733837512 0.760869565217391 7.2 7 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 8.74438082181567e-07 4.42820423823619e-06 1.12636733837512 0.760869565217391 7.2 7 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 9.62794348014717e-10 7.82889346985682e-09 1.12591407184056 0.76056338028169 7.2 7 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 4.04158021000419e-13 7.46905018030645e-12 1.12508006141698 0.76 7.2 7 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 3.11019178014403e-07 1.65760408357489e-06 1.12508006141698 0.76 7.2 7 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.000315351197279811 0.000990606520373445 1.12508006141698 0.76 7.2 7 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000315351197279811 0.000990606520373445 1.12508006141698 0.76 7.2 7 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000315351197279811 0.000990606520373445 1.12508006141698 0.76 7.2 7 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 4.50154996741327e-11 5.00445750283522e-10 1.12365320021036 0.759036144578313 7.2 7 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 1.33327276188946e-05 5.3144177595762e-05 1.1202788662758 0.756756756756757 7.2 7 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 4.7655939292654e-15 1.41280003361347e-13 1.11960642998151 0.756302521008403 7.2 7 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.66365373918629e-06 8.05231044510914e-06 1.11850064585314 0.755555555555556 7.2 7 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 6.8588442770317e-14 1.52502115722127e-12 1.11700532413408 0.754545454545455 7.2 7 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 6.8588442770317e-14 1.52502115722127e-12 1.11700532413408 0.754545454545455 7.2 7 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 2.91842487922933e-16 1.03822965078583e-14 1.11305902395823 0.75187969924812 7.2 7 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 3.14429881929401e-06 1.44333458705012e-05 1.11027637639833 0.75 7.2 7 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000601931581354841 0.00176972859559491 1.11027637639833 0.75 7.2 7 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.000601931581354841 0.00176972859559491 1.11027637639833 0.75 7.2 7 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000601931581354841 0.00176972859559491 1.11027637639833 0.75 7.2 7 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0161604987188207 0.0321627827648697 1.11027637639833 0.75 7.2 7 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 6.70140669105345e-13 1.1629392343133e-11 1.11027637639833 0.75 7.2 7 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.8130726602401e-08 1.10713015671549e-07 1.11027637639833 0.75 7.2 7 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 3.96953055181963e-07 2.09208962045901e-06 1.11027637639833 0.75 7.2 7 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 3.96953055181963e-07 2.09208962045901e-06 1.11027637639833 0.75 7.2 7 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 3.96953055181963e-07 2.09208962045901e-06 1.11027637639833 0.75 7.2 7 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 8.89410773449885e-06 3.63687221442295e-05 1.11027637639833 0.75 7.2 7 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 2.52670855463829e-05 9.71758452229806e-05 1.11027637639833 0.75 7.2 7 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 2.52670855463829e-05 9.71758452229806e-05 1.11027637639833 0.75 7.2 7 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 7.2164929175127e-05 0.000254815618402495 1.11027637639833 0.75 7.2 7 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.00176692545422144 0.0046161169478177 1.11027637639833 0.75 7.2 7 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.00176692545422144 0.0046161169478177 1.11027637639833 0.75 7.2 7 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00176692545422144 0.0046161169478177 1.11027637639833 0.75 7.2 7 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00527494613682421 0.0121264109090482 1.11027637639833 0.75 7.2 7 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00527494613682421 0.0121264109090482 1.11027637639833 0.75 7.2 7 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00527494613682421 0.0121264109090482 1.11027637639833 0.75 7.2 7 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00527494613682421 0.0121264109090482 1.11027637639833 0.75 7.2 7 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0517761933526764 0.0890901126249802 1.11027637639833 0.75 7.2 7 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 8.47951175521182e-21 4.46901675098756e-19 1.10016456969161 0.743169398907104 7.2 7 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 4.74869698834304e-05 0.000173266559343901 1.09970231567073 0.742857142857143 7.2 7 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 4.74869698834304e-05 0.000173266559343901 1.09970231567073 0.742857142857143 7.2 7 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 4.74869698834304e-05 0.000173266559343901 1.09970231567073 0.742857142857143 7.2 7 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 8.56597569087954e-29 8.1262556054144e-27 1.09888892638399 0.742307692307692 7.2 7 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 3.69738222149332e-18 1.69721771005968e-16 1.09863825924531 0.742138364779874 7.2 7 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.000390794234012567 0.00118571470149229 1.09656926064033 0.740740740740741 7.2 7 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 1.38724905047755e-06 6.76046369462176e-06 1.09547269137969 0.74 7.2 7 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 3.89976476736633e-06 1.75612824808933e-05 1.09418541442155 0.739130434782609 7.2 7 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.26626813555299e-17 5.63093611528722e-16 1.09377545360685 0.738853503184713 7.2 7 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.59459199145497e-23 3.46134974080018e-21 1.09265294185233 0.738095238095238 7.2 7 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 3.1119629590972e-05 0.0001171514098094 1.09079784347906 0.736842105263158 7.2 7 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 1.00649548496671e-08 6.30944085950497e-08 1.08971570276133 0.736111111111111 7.2 7 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 8.84610839174883e-05 0.00030777536042686 1.08850625137091 0.735294117647059 7.2 7 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.36383984657551e-19 1.65060141437136e-17 1.08727630080439 0.734463276836158 7.2 7 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.45646416782153e-15 7.59901850176094e-14 1.08631357690772 0.733812949640288 7.2 7 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.45646416782153e-15 7.59901850176094e-14 1.08631357690772 0.733812949640288 7.2 7 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00999881214141499 0.0214929149202923 1.08560356803393 0.733333333333333 7.2 7 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.00999881214141499 0.0214929149202923 1.08560356803393 0.733333333333333 7.2 7 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.51453034608873e-38 3.59196113747376e-36 1.08454804682047 0.732620320855615 7.2 7 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 4.40116513667328e-12 6.19631498198208e-11 1.08286214488232 0.731481481481482 7.2 7 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 5.13783135362395e-08 2.97200569764507e-07 1.08265756106504 0.73134328358209 7.2 7 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.21197337573255e-11 1.49622870551558e-10 1.08180775136248 0.730769230769231 7.2 7 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 4.72374423431073e-06 1.98367601192642e-05 1.07943536594282 0.729166666666667 7.2 7 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 3.38797082992716e-08 1.98398456419191e-07 1.07855419421552 0.728571428571429 7.2 7 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.00211371672399987 0.00533301223094293 1.0766316377196 0.727272727272727 7.2 7 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.030768669997887 0.0557046022989735 1.0766316377196 0.727272727272727 7.2 7 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.72915327280687e-05 0.000139646976505373 1.07326716385172 0.725 7.2 7 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 6.16970497318845e-08 3.52589966941653e-07 1.0727307984525 0.72463768115942 7.2 7 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.05117674031113e-15 3.56148690824462e-14 1.07131931055979 0.723684210526316 7.2 7 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 1.70788499384636e-07 9.38037951473781e-07 1.07042030134814 0.723076923076923 7.2 7 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00621481726042165 0.0141725720538141 1.06915502912432 0.722222222222222 7.2 7 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.15082541039335e-14 5.18749925252498e-13 1.06798013348792 0.721428571428571 7.2 7 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.15194171147689e-11 1.43790618897509e-10 1.066932253596 0.720720720720721 7.2 7 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.32039119819307e-21 1.32076667001149e-19 1.0631737422481 0.718181818181818 7.2 7 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 1.56343931536971e-05 6.17992818269749e-05 1.06200349046797 0.717391304347826 7.2 7 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.56343931536971e-05 6.17992818269749e-05 1.06200349046797 0.717391304347826 7.2 7 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.70646266332262e-09 2.02699808942531e-08 1.05980926838023 0.715909090909091 7.2 7 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.47002814037841e-10 5.44784026257898e-09 1.05963219080823 0.715789473684211 7.2 7 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 6.47002814037841e-10 5.44784026257898e-09 1.05963219080823 0.715789473684211 7.2 7 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 6.47002814037841e-10 5.44784026257898e-09 1.05963219080823 0.715789473684211 7.2 7 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.43703302169384e-11 2.86603139658705e-10 1.05740607276032 0.714285714285714 7.2 7 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000849016563799143 0.00241147818420395 1.05740607276032 0.714285714285714 7.2 7 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0185937112699551 0.036646608223194 1.05740607276032 0.714285714285714 7.2 7 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0185937112699551 0.036646608223194 1.05740607276032 0.714285714285714 7.2 7 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0185937112699551 0.036646608223194 1.05740607276032 0.714285714285714 7.2 7 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0185937112699551 0.036646608223194 1.05740607276032 0.714285714285714 7.2 7 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0185937112699551 0.036646608223194 1.05740607276032 0.714285714285714 7.2 7 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0185937112699551 0.036646608223194 1.05740607276032 0.714285714285714 7.2 7 2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0993289502299009 0.157732124335405 1.05740607276032 0.714285714285714 7.2 7 2 ANCHORING FIBRIL FORMATION%REACTOME%REACT_196595.2 ANCHORING FIBRIL FORMATION 0.0993289502299009 0.157732124335405 1.05740607276032 0.714285714285714 7.2 7 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0993289502299009 0.157732124335405 1.05740607276032 0.714285714285714 7.2 7 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0993289502299009 0.157732124335405 1.05740607276032 0.714285714285714 7.2 7 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0993289502299009 0.157732124335405 1.05740607276032 0.714285714285714 7.2 7 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0993289502299009 0.157732124335405 1.05740607276032 0.714285714285714 7.2 7 2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0993289502299009 0.157732124335405 1.05740607276032 0.714285714285714 7.2 7 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0993289502299009 0.157732124335405 1.05740607276032 0.714285714285714 7.2 7 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 8.18218502995211e-14 1.74456510378221e-12 1.05740607276032 0.714285714285714 7.2 7 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 1.01116499460435e-05 4.1228876427564e-05 1.05740607276032 0.714285714285714 7.2 7 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.84150132579771e-09 3.46310386235586e-08 1.05497525420225 0.71264367816092 7.2 7 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.05502168697445e-13 1.09067036209679e-11 1.05420181193377 0.712121212121212 7.2 7 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 6.53673157528484e-06 2.70400262547393e-05 1.05333912632662 0.711538461538462 7.2 7 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.20350942889665e-79 1.16735939173199e-75 1.05333912632662 0.711538461538462 7.2 7 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 2.81178152311861e-05 0.000107558201811768 1.05270649021472 0.711111111111111 7.2 7 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00012221676137878 0.000413098459482196 1.05184077764053 0.710526315789474 7.2 7 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00012221676137878 0.000413098459482196 1.05184077764053 0.710526315789474 7.2 7 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.000539081515353828 0.00159482951423804 1.05058409809735 0.709677419354839 7.2 7 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.000539081515353828 0.00159482951423804 1.05058409809735 0.709677419354839 7.2 7 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 8.62262157629269e-09 5.92753164399251e-08 1.0500288210899 0.709302325581395 7.2 7 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.92191435145251e-12 4.3311292938718e-11 1.04908004069134 0.708661417322835 7.2 7 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.00243074720949313 0.00605771152208183 1.04859435548731 0.708333333333333 7.2 7 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.000342729875504358 0.00106591896581037 1.04496600131608 0.705882352941177 7.2 7 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0113673234230092 0.023893207135808 1.04496600131608 0.705882352941177 7.2 7 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0113673234230092 0.023893207135808 1.04496600131608 0.705882352941177 7.2 7 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 6.41180297331053e-08 3.64959825240835e-07 1.04384958464801 0.705128205128205 7.2 7 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.71133150891505e-10 3.28026381191685e-09 1.04330732512351 0.704761904761905 7.2 7 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00152802972330642 0.00407952400800195 1.04174079760831 0.703703703703704 7.2 7 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00152802972330642 0.00407952400800195 1.04174079760831 0.703703703703704 7.2 7 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00152802972330642 0.00407952400800195 1.04174079760831 0.703703703703704 7.2 7 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 2.32341485336292e-14 5.51036556055907e-13 1.04000571966426 0.70253164556962 7.2 7 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000139038049401614 0.000466669300369906 1.03625795130511 0.7 7.2 7 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00096327771196506 0.00271434491906194 1.03625795130511 0.7 7.2 7 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00096327771196506 0.00271434491906194 1.03625795130511 0.7 7.2 7 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.00096327771196506 0.00271434491906194 1.03625795130511 0.7 7.2 7 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00700895140032635 0.0156819777400384 1.03625795130511 0.7 7.2 7 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00700895140032635 0.0156819777400384 1.03625795130511 0.7 7.2 7 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00700895140032635 0.0156819777400384 1.03625795130511 0.7 7.2 7 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00700895140032635 0.0156819777400384 1.03625795130511 0.7 7.2 7 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0571253588367233 0.0970040401248894 1.03625795130511 0.7 7.2 7 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0571253588367233 0.0970040401248894 1.03625795130511 0.7 7.2 7 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0571253588367233 0.0970040401248894 1.03625795130511 0.7 7.2 7 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0571253588367233 0.0970040401248894 1.03625795130511 0.7 7.2 7 2 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0571253588367233 0.0970040401248894 1.03625795130511 0.7 7.2 7 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0571253588367233 0.0970040401248894 1.03625795130511 0.7 7.2 7 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0571253588367233 0.0970040401248894 1.03625795130511 0.7 7.2 7 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0571253588367233 0.0970040401248894 1.03625795130511 0.7 7.2 7 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.81147499495445e-11 3.22639428856467e-10 1.03505439967758 0.699186991869919 7.2 7 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.06671201646273e-08 1.8183046664277e-07 1.03281523385891 0.697674418604651 7.2 7 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 8.8705903143907e-05 0.000307874390667755 1.03281523385891 0.697674418604651 7.2 7 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.98357448160218e-07 1.08146608709575e-06 1.03236224472126 0.697368421052632 7.2 7 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 3.08944282807999e-09 2.26612223935971e-08 1.03177198614795 0.696969696969697 7.2 7 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.00435001520271538 0.0101476584155147 1.0298215665144 0.695652173913043 7.2 7 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00435001520271538 0.0101476584155147 1.0298215665144 0.695652173913043 7.2 7 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000385527505009173 0.00117223427270951 1.02803368185031 0.694444444444444 7.2 7 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 5.35042922020491e-08 3.07002450820629e-07 1.02754990129414 0.694117647058824 7.2 7 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 5.35042922020491e-08 3.07002450820629e-07 1.02754990129414 0.694117647058824 7.2 7 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 9.14319841404579e-14 1.88561903524452e-12 1.02700564816846 0.69375 7.2 7 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 3.50751317640672e-06 1.58955135351171e-05 1.02670718677695 0.693548387096774 7.2 7 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00271382682978228 0.00670219676437232 1.02487050129077 0.692307692307692 7.2 7 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0338249620250449 0.0609277480527074 1.02487050129077 0.692307692307692 7.2 7 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0338249620250449 0.0609277480527074 1.02487050129077 0.692307692307692 7.2 7 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.43979770317592e-07 8.03463581027187e-07 1.02346464326431 0.691358024691358 7.2 7 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 1.45030436153598e-06 7.04362834971226e-06 1.02319587628866 0.691176470588235 7.2 7 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 9.60612240352009e-11 1.0434742122297e-09 1.02301888340226 0.691056910569106 7.2 7 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 1.48351408046086e-05 5.89676127512795e-05 1.02280005583362 0.690909090909091 7.2 7 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.000155471320479324 0.000513307863206677 1.02215920366831 0.69047619047619 7.2 7 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000155471320479324 0.000513307863206677 1.02215920366831 0.69047619047619 7.2 7 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00170021804450945 0.00451382514428535 1.02094379438927 0.689655172413793 7.2 7 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00170021804450945 0.00451382514428535 1.02094379438927 0.689655172413793 7.2 7 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.15181946027463e-13 2.34148441710114e-12 1.02001000433343 0.689024390243902 7.2 7 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.0203913173515147 0.039532485819081 1.01775334503181 0.6875 7.2 7 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0203913173515147 0.039532485819081 1.01775334503181 0.6875 7.2 7 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 8.10883441151078e-13 1.39022546597347e-11 1.01538095961215 0.685897435897436 7.2 7 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000674002980599034 0.0019533732003919 1.0151098298499 0.685714285714286 7.2 7 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 6.16945020121911e-15 1.75582552726696e-13 1.01330036491256 0.684491978609626 7.2 7 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 6.66251555712087e-07 3.41034519344712e-06 1.01288371180199 0.684210526315789 7.2 7 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0124445993088873 0.0260039130933137 1.01288371180199 0.684210526315789 7.2 7 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0124445993088873 0.0260039130933137 1.01288371180199 0.684210526315789 7.2 7 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 4.28536738032839e-07 2.25021320376653e-06 1.01189745697063 0.683544303797468 7.2 7 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 2.7574723480091e-07 1.48071062310073e-06 1.01098336712694 0.682926829268293 7.2 7 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00475102332059127 0.0110109221257351 1.00665058126782 0.68 7.2 7 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00475102332059127 0.0110109221257351 1.00665058126782 0.68 7.2 7 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00475102332059127 0.0110109221257351 1.00665058126782 0.68 7.2 7 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00475102332059127 0.0110109221257351 1.00665058126782 0.68 7.2 7 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.45592461671971e-10 1.36301363788957e-09 1.00574653943462 0.679389312977099 7.2 7 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.45592461671971e-10 1.36301363788957e-09 1.00574653943462 0.679389312977099 7.2 7 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 4.42062398972142e-05 0.000162967563144393 1.00553332202113 0.679245283018868 7.2 7 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 4.44149071090775e-12 6.19631498198208e-11 1.00283027545656 0.67741935483871 7.2 7 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00185408972484865 0.00477101207678052 1.00283027545656 0.67741935483871 7.2 7 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00116496845259961 0.00320028978387884 1.00142575126124 0.676470588235294 7.2 7 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00116496845259961 0.00320028978387884 1.00142575126124 0.676470588235294 7.2 7 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00116496845259961 0.00320028978387884 1.00142575126124 0.676470588235294 7.2 7 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00116496845259961 0.00320028978387884 1.00142575126124 0.676470588235294 7.2 7 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00116496845259961 0.00320028978387884 1.00142575126124 0.676470588235294 7.2 7 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000463904442283533 0.00140454472631802 0.9992487387585 0.675 7.2 7 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000293771113531263 0.000935204238378049 0.998388059396951 0.674418604651163 7.2 7 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 7.29252415322487e-23 4.32385911251625e-21 0.994480680700347 0.671779141104294 7.2 7 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.20569215332312e-15 9.70574454080597e-14 0.993961708394698 0.671428571428571 7.2 7 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.94402403304592e-13 5.51229763029518e-12 0.989594161572427 0.668478260869565 7.2 7 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0002005911701919 0.000653183604537927 0.986912334576296 0.666666666666667 7.2 7 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00818855118915988 0.0182924777742143 0.986912334576296 0.666666666666667 7.2 7 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0599850125560197 0.101376096041824 0.986912334576296 0.666666666666667 7.2 7 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 2.99135629779264e-35 4.72966667973214e-33 0.986912334576296 0.666666666666667 7.2 7 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000498783913942999 0.00148487345092236 0.986912334576296 0.666666666666667 7.2 7 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0132680268589807 0.0271270146843816 0.986912334576296 0.666666666666667 7.2 7 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0132680268589807 0.0271270146843816 0.986912334576296 0.666666666666667 7.2 7 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0132680268589807 0.0271270146843816 0.986912334576296 0.666666666666667 7.2 7 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0216723357481842 0.0415629835170702 0.986912334576296 0.666666666666667 7.2 7 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0216723357481842 0.0415629835170702 0.986912334576296 0.666666666666667 7.2 7 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0216723357481842 0.0415629835170702 0.986912334576296 0.666666666666667 7.2 7 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0216723357481842 0.0415629835170702 0.986912334576296 0.666666666666667 7.2 7 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0357835095270352 0.0642117705636458 0.986912334576296 0.666666666666667 7.2 7 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0357835095270352 0.0642117705636458 0.986912334576296 0.666666666666667 7.2 7 2 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.102893958185433 0.160722395716653 0.986912334576296 0.666666666666667 7.2 7 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 5.12058142944636e-09 3.64329368705109e-08 0.982867611893606 0.663934426229508 7.2 7 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 6.46961461685539e-07 3.32356014432679e-06 0.981367883258451 0.662921348314607 7.2 7 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 5.53131491710353e-05 0.000199773125051734 0.978548670723954 0.661016949152542 7.2 7 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.52880908346509e-18 1.67383177525694e-16 0.978005183542214 0.660649819494585 7.2 7 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 4.9195478241145e-08 2.85735369539385e-07 0.977858092974679 0.660550458715596 7.2 7 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00210598560726737 0.00532294408373263 0.972813586939492 0.657142857142857 7.2 7 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 4.29438749529448e-06 1.85179194115274e-05 0.96863618023229 0.654320987654321 7.2 7 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.20570641599799e-06 5.9781192681712e-06 0.965457718607246 0.652173913043478 7.2 7 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0138749902046518 0.0282866920647843 0.965457718607246 0.652173913043478 7.2 7 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0138749902046518 0.0282866920647843 0.965457718607246 0.652173913043478 7.2 7 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 4.52851576060855e-06 1.92360535144656e-05 0.963131314466024 0.650602409638554 7.2 7 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.98818269450797e-09 1.57176887460269e-08 0.962757137576177 0.65034965034965 7.2 7 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 3.05978201388855e-06 1.40908407953508e-05 0.958875052344015 0.647727272727273 7.2 7 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0369353062204415 0.0656166551207094 0.957885501206405 0.647058823529412 7.2 7 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0369353062204415 0.0656166551207094 0.957885501206405 0.647058823529412 7.2 7 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0369353062204415 0.0656166551207094 0.957885501206405 0.647058823529412 7.2 7 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0369353062204415 0.0656166551207094 0.957885501206405 0.647058823529412 7.2 7 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 4.7535735774203e-06 1.98367601192642e-05 0.957885501206405 0.647058823529412 7.2 7 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 4.7535735774203e-06 1.98367601192642e-05 0.957885501206405 0.647058823529412 7.2 7 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 4.7535735774203e-06 1.98367601192642e-05 0.957885501206405 0.647058823529412 7.2 7 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 4.7535735774203e-06 1.98367601192642e-05 0.957885501206405 0.647058823529412 7.2 7 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 4.7535735774203e-06 1.98367601192642e-05 0.957885501206405 0.647058823529412 7.2 7 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 8.98843718806822e-12 1.14201304630545e-10 0.956071324120787 0.645833333333333 7.2 7 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00557411504550661 0.0127934930802515 0.95507645281577 0.645161290322581 7.2 7 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00144869758280461 0.00388961634024711 0.951665465484285 0.642857142857143 7.2 7 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00890847541157593 0.0194316807560483 0.951665465484285 0.642857142857143 7.2 7 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0612412133842066 0.103253846736642 0.951665465484285 0.642857142857143 7.2 7 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00228717958835381 0.0057401350162742 0.948954167861823 0.641025641025641 7.2 7 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00228717958835381 0.0057401350162742 0.948954167861823 0.641025641025641 7.2 7 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00228717958835381 0.0057401350162742 0.948954167861823 0.641025641025641 7.2 7 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.23131312582152e-41 3.50431715608806e-39 0.947739117710912 0.640204865556978 7.2 7 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0142997118443929 0.0289452204190201 0.947435841193244 0.64 7.2 7 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0142997118443929 0.0289452204190201 0.947435841193244 0.64 7.2 7 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0142997118443929 0.0289452204190201 0.947435841193244 0.64 7.2 7 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0142997118443929 0.0289452204190201 0.947435841193244 0.64 7.2 7 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 3.1220630594932e-10 2.77668483353676e-09 0.946747297704005 0.63953488372093 7.2 7 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.14542545037702e-07 6.44245223670556e-07 0.946465107749399 0.639344262295082 7.2 7 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000164042367754502 0.000536625952447486 0.946465107749399 0.639344262295082 7.2 7 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.41434536555631e-08 8.71261236011528e-08 0.944916065019858 0.638297872340426 7.2 7 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.18858812589592e-07 6.65890119350351e-07 0.943137997155573 0.637096774193548 7.2 7 2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.103249564304687 0.160995279550325 0.942052683004646 0.636363636363636 7.2 7 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00573969635323818 0.0131311702743697 0.942052683004646 0.636363636363636 7.2 7 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00573969635323818 0.0131311702743697 0.942052683004646 0.636363636363636 7.2 7 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.000625569747231934 0.0018354345367238 0.939464626183205 0.634615384615385 7.2 7 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00235374839088605 0.00588643929741801 0.938770269475013 0.634146341463415 7.2 7 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00235374839088605 0.00588643929741801 0.938770269475013 0.634146341463415 7.2 7 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000979075710451712 0.00275340856911618 0.936559664444852 0.63265306122449 7.2 7 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0374913125012647 0.0665213686898998 0.934969580124912 0.631578947368421 7.2 7 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 3.17401918728294e-05 0.000119172277137299 0.93208387154428 0.62962962962963 7.2 7 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000115004920681816 0.000393394235889963 0.930517344029079 0.628571428571429 7.2 7 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00586032678612312 0.0133856260299409 0.930517344029079 0.628571428571429 7.2 7 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.75934674541874e-07 2.4538226154822e-06 0.929818232576014 0.628099173553719 7.2 7 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00240588657771161 0.00600627473698881 0.929533710473023 0.627906976744186 7.2 7 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 2.59832449903958e-06 1.21625518491228e-05 0.926959716120727 0.626168224299065 7.2 7 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00156414985270945 0.00416813715431751 0.925230313665278 0.625 7.2 7 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.00927588396479352 0.0200601563554729 0.925230313665277 0.625 7.2 7 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00927588396479352 0.0200601563554729 0.925230313665277 0.625 7.2 7 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0614371631529027 0.103339341804469 0.925230313665277 0.625 7.2 7 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0614371631529027 0.103339341804469 0.925230313665277 0.625 7.2 7 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.178583545025275 0.264414480738493 0.925230313665277 0.625 7.2 7 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.178583545025275 0.264414480738493 0.925230313665277 0.625 7.2 7 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.178583545025275 0.264414480738493 0.925230313665277 0.625 7.2 7 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.178583545025275 0.264414480738493 0.925230313665277 0.625 7.2 7 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.36471102862745e-12 2.15775977081873e-11 0.922293074574277 0.623015873015873 7.2 7 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.36471102862745e-12 2.15775977081873e-11 0.922293074574277 0.623015873015873 7.2 7 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.36471102862745e-12 2.15775977081873e-11 0.922293074574277 0.623015873015873 7.2 7 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000281389943818933 0.000897797959763098 0.919622857218821 0.621212121212121 7.2 7 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.000665588360194869 0.00193292293174959 0.918849414950345 0.620689655172414 7.2 7 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.000665588360194869 0.00193292293174959 0.918849414950345 0.620689655172414 7.2 7 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.000665588360194869 0.00193292293174959 0.918849414950345 0.620689655172414 7.2 7 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 7.22700264964249e-69 5.14201238522063e-66 0.916509614775985 0.619109102646869 7.2 7 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.03760531309422 0.0666405486090598 0.916418596392275 0.619047619047619 7.2 7 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000121508060506734 0.000413098459482196 0.915491047205643 0.618421052631579 7.2 7 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 4.22071022523676e-06 1.82555338921335e-05 0.915136892061656 0.618181818181818 7.2 7 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0093569320817238 0.0202047258760136 0.914345251151568 0.617647058823529 7.2 7 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0234207529769195 0.0446154370631278 0.91099600114735 0.615384615384615 7.2 7 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0234207529769195 0.0446154370631278 0.91099600114735 0.615384615384615 7.2 7 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.101841093405579 0.160722395716653 0.91099600114735 0.615384615384615 7.2 7 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.101841093405579 0.160722395716653 0.91099600114735 0.615384615384615 7.2 7 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.101841093405579 0.160722395716653 0.91099600114735 0.615384615384615 7.2 7 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.101841093405579 0.160722395716653 0.91099600114735 0.615384615384615 7.2 7 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0147602370239362 0.0298349677344619 0.907322630174982 0.612903225806452 7.2 7 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.00248795112995852 0.00615713818770604 0.906348062365986 0.612244897959184 7.2 7 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.89531865550204e-06 1.34203206735486e-05 0.905349331718751 0.611570247933884 7.2 7 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.89531865550204e-06 1.34203206735486e-05 0.905349331718751 0.611570247933884 7.2 7 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00938282980455999 0.0202299497149831 0.904669640028271 0.611111111111111 7.2 7 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0609199741054173 0.102834072540936 0.904669640028271 0.611111111111111 7.2 7 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.43004969215908e-26 1.07103195365388e-24 0.902495260856706 0.609642301710731 7.2 7 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.05397937349313e-23 7.14196499276534e-22 0.902221083448032 0.609457092819615 7.2 7 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.483445816241e-07 1.33861492292081e-06 0.897771865646824 0.606451612903226 7.2 7 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00385713725511927 0.0093345345476781 0.894389303209768 0.604166666666667 7.2 7 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 4.16036074209069e-38 8.4574190514215e-36 0.89207391203443 0.602602602602603 7.2 7 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.58633120282662e-10 1.47539170040672e-09 0.891788254135207 0.602409638554217 7.2 7 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00248246276851216 0.0061542587449352 0.888221101118666 0.6 7.2 7 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00248246276851216 0.0061542587449352 0.888221101118666 0.6 7.2 7 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0231010506820393 0.0441245572087811 0.888221101118666 0.6 7.2 7 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0599192202588395 0.101376096041824 0.888221101118666 0.6 7.2 7 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0599192202588395 0.101376096041824 0.888221101118666 0.6 7.2 7 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0994277691699634 0.157732124335405 0.888221101118666 0.6 7.2 7 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0994277691699634 0.157732124335405 0.888221101118666 0.6 7.2 7 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.171546857208497 0.255613798751509 0.888221101118666 0.6 7.2 7 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.171546857208497 0.255613798751509 0.888221101118666 0.6 7.2 7 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.171546857208497 0.255613798751509 0.888221101118666 0.6 7.2 7 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.171546857208497 0.255613798751509 0.888221101118666 0.6 7.2 7 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 7.18648591891074e-08 4.05808312008332e-07 0.878968797982014 0.59375 7.2 7 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.036291303785421 0.0647961421413476 0.877255408512263 0.592592592592593 7.2 7 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.036291303785421 0.0647961421413476 0.877255408512263 0.592592592592593 7.2 7 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.036291303785421 0.0647961421413476 0.877255408512263 0.592592592592593 7.2 7 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.79306465048979e-17 7.73191211408172e-16 0.87558380902958 0.591463414634146 7.2 7 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0964398159135615 0.155066506265535 0.870805001096732 0.588235294117647 7.2 7 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00878458221849552 0.0193505580447665 0.863548292754259 0.583333333333333 7.2 7 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0570440090850742 0.0970040401248894 0.863548292754259 0.583333333333333 7.2 7 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.01465636156695e-14 2.57831429019601e-13 0.862995090772994 0.582959641255605 7.2 7 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0346498695932588 0.0623347211519688 0.859568807534193 0.580645161290323 7.2 7 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 5.83564622847088e-06 2.42102757525191e-05 0.858047985157098 0.579617834394904 7.2 7 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0213992397257861 0.0412616776826472 0.857055448447836 0.578947368421053 7.2 7 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0337139363717364 0.0608818927119048 0.852333379861346 0.575757575757576 7.2 7 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0337139363717364 0.0608818927119048 0.852333379861346 0.575757575757576 7.2 7 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.15597426676741 0.239429753624622 0.845924858208254 0.571428571428571 7.2 7 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.15597426676741 0.239429753624622 0.845924858208254 0.571428571428571 7.2 7 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.000800880917500823 0.00227930709120734 0.839384202088087 0.56701030927835 7.2 7 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0517566632864959 0.0890901126249802 0.838875484389852 0.566666666666667 7.2 7 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0120112117171214 0.0252093720847549 0.83794443501761 0.566037735849057 7.2 7 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0861516475963841 0.14091240750535 0.836730022792947 0.565217391304348 7.2 7 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0306995216265782 0.0557046022989735 0.835079667718404 0.564102564102564 7.2 7 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.148272834049041 0.228593979254372 0.83270728229875 0.5625 7.2 7 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.148272834049041 0.228593979254372 0.83270728229875 0.5625 7.2 7 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0296713147789974 0.0546213207380508 0.830450622997127 0.560975609756098 7.2 7 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0826418705569028 0.135483158758609 0.829006361044089 0.56 7.2 7 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00244710997856925 0.00608782779633573 0.822426945480247 0.555555555555556 7.2 7 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00392492781904675 0.00948246568166983 0.822426945480247 0.555555555555556 7.2 7 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0102522230259067 0.0220043942169913 0.822426945480247 0.555555555555556 7.2 7 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0276329271276228 0.0509347866614083 0.822426945480247 0.555555555555556 7.2 7 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.140839618173742 0.217605620696237 0.822426945480247 0.555555555555556 7.2 7 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.140839618173742 0.217605620696237 0.822426945480247 0.555555555555556 7.2 7 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.273195528575077 0.381134546237583 0.822426945480247 0.555555555555556 7.2 7 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.273195528575077 0.381134546237583 0.822426945480247 0.555555555555556 7.2 7 2 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605614 LYSOSPHINGOLIPID AND LPA RECEPTORS 0.273195528575077 0.381134546237583 0.822426945480247 0.555555555555556 7.2 7 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000517738503509522 0.00153808327869321 0.81595114275993 0.551181102362205 7.2 7 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0256538633174171 0.0487497023120349 0.815713256129387 0.551020408163265 7.2 7 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.62419890420145e-11 3.03596344770623e-10 0.813455015165917 0.549494949494949 7.2 7 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.126967170246235 0.197027571712532 0.807473728289697 0.545454545454545 7.2 7 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.253503608693068 0.35569421930328 0.807473728289697 0.545454545454545 7.2 7 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0219684915364731 0.0420742442212667 0.805112693996452 0.543859649122807 7.2 7 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0377720759394027 0.0668528159972265 0.804548098839372 0.543478260869565 7.2 7 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0362230694366776 0.0647961421413476 0.801866271843241 0.541666666666667 7.2 7 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0202837644289837 0.0394314163694588 0.800855091172568 0.540983606557377 7.2 7 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0633685795087061 0.10646220618759 0.800199190196997 0.540540540540541 7.2 7 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.236128587324602 0.33567530445845 0.797121501003931 0.538461538461538 7.2 7 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.236128587324602 0.33567530445845 0.797121501003931 0.538461538461538 7.2 7 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.236128587324602 0.33567530445845 0.797121501003931 0.538461538461538 7.2 7 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.236128587324602 0.33567530445845 0.797121501003931 0.538461538461538 7.2 7 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0578502069354161 0.0981178122396867 0.794344074171165 0.536585365853659 7.2 7 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.53531924683503e-05 9.72441856670148e-05 0.794189110442298 0.536480686695279 7.2 7 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0527925420543268 0.090729211767279 0.789529867661037 0.533333333333333 7.2 7 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.103294933400876 0.160995279550325 0.789529867661037 0.533333333333333 7.2 7 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.000150039729825983 0.000498005023761917 0.789028896932825 0.532994923857868 7.2 7 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0257286092550631 0.0487497023120349 0.786445766615486 0.53125 7.2 7 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.206584979451455 0.296042724833254 0.783724500987059 0.529411764705882 7.2 7 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.206584979451455 0.296042724833254 0.783724500987059 0.529411764705882 7.2 7 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0225944919839057 0.0432150028133034 0.782480493842635 0.528571428571429 7.2 7 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.193845434132203 0.278628336131439 0.77914131677076 0.526315789473684 7.2 7 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.182196252994738 0.264414480738493 0.775431120024233 0.523809523809524 7.2 7 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.152483161385606 0.234576798542397 0.76759848244823 0.518518518518518 7.2 7 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.152483161385606 0.234576798542397 0.76759848244823 0.518518518518518 7.2 7 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0212878126330766 0.0411025201857096 0.766308400965124 0.517647058823529 7.2 7 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0212878126330766 0.0411025201857096 0.766308400965124 0.517647058823529 7.2 7 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.128754142187727 0.199582945896662 0.762614076718047 0.515151515151515 7.2 7 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000219497264122631 0.000713115540745442 0.760503034291146 0.513725490196078 7.2 7 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0984494409013067 0.157732124335405 0.757397838163204 0.511627906976744 7.2 7 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00403460558016709 0.00963295929627142 0.753976504055183 0.509316770186335 7.2 7 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00497646240633277 0.011514643909287 0.749322328104225 0.506172839506173 7.2 7 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00665781533202534 0.0149906190149874 0.744839497793431 0.50314465408805 7.2 7 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00665781533202534 0.0149906190149874 0.744839497793431 0.50314465408805 7.2 7 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.196236940568339 0.281781197203578 0.740184250932222 0.5 7.2 7 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.208764348883978 0.298864857607546 0.740184250932222 0.5 7.2 7 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.222434805891486 0.317795912433317 0.740184250932222 0.5 7.2 7 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.237425335743241 0.337181888984663 0.740184250932222 0.5 7.2 7 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.316282907881795 0.433594005699223 0.740184250932222 0.5 7.2 7 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.316282907881795 0.433594005699223 0.740184250932222 0.5 7.2 7 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.316282907881795 0.433594005699223 0.740184250932222 0.5 7.2 7 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.316282907881795 0.433594005699223 0.740184250932222 0.5 7.2 7 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.343187280633317 0.45941251208016 0.740184250932222 0.5 7.2 7 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.343187280633317 0.45941251208016 0.740184250932222 0.5 7.2 7 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.343187280633317 0.45941251208016 0.740184250932222 0.5 7.2 7 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.343187280633317 0.45941251208016 0.740184250932222 0.5 7.2 7 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.343187280633317 0.45941251208016 0.740184250932222 0.5 7.2 7 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.117721950580515 0.183080148279861 0.740184250932222 0.5 7.2 7 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.184709958568437 0.265765693673292 0.740184250932222 0.5 7.2 7 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.253960173444928 0.35569421930328 0.740184250932222 0.5 7.2 7 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.253960173444928 0.35569421930328 0.740184250932222 0.5 7.2 7 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.272330340729169 0.381048254530588 0.740184250932222 0.5 7.2 7 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.292924836851373 0.406665407648296 0.740184250932222 0.5 7.2 7 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.292924836851373 0.406665407648296 0.740184250932222 0.5 7.2 7 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.292924836851373 0.406665407648296 0.740184250932222 0.5 7.2 7 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.292924836851373 0.406665407648296 0.740184250932222 0.5 7.2 7 2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.374844199941657 0.489360822492641 0.740184250932222 0.5 7.2 7 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.374844199941657 0.489360822492641 0.740184250932222 0.5 7.2 7 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.374844199941657 0.489360822492641 0.740184250932222 0.5 7.2 7 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0954076482684312 0.153754341433723 0.740184250932222 0.5 7.2 7 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0643129105940189 0.107915959118613 0.730814830034346 0.493670886075949 7.2 7 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.0822513041230836 0.134998391888291 0.729456942947697 0.492753623188406 7.2 7 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0169701204608834 0.0337269293517279 0.725858104139985 0.490322580645161 7.2 7 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0556228283106844 0.0954780273656259 0.724435649848558 0.48936170212766 7.2 7 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.216713429076752 0.309932873945947 0.717754425146397 0.484848484848485 7.2 7 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0210014641074386 0.0406599774488234 0.717479212560068 0.484662576687117 7.2 7 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0698926748169077 0.114979510132323 0.716307339611828 0.483870967741935 7.2 7 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.244989135513109 0.347576809406933 0.71466065607249 0.482758620689655 7.2 7 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.297863131465647 0.409921891755914 0.708002326978647 0.478260869565217 7.2 7 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0957309100662165 0.154100774914283 0.706539512253485 0.477272727272727 7.2 7 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0121091335566592 0.0253774625200678 0.702449367551364 0.474509803921569 7.2 7 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0977072051288125 0.156927034873928 0.701227185093684 0.473684210526316 7.2 7 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.179759738019666 0.264414480738493 0.699810564517737 0.472727272727273 7.2 7 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.103967641731503 0.161866470660754 0.695773195876289 0.47 7.2 7 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.279862845906976 0.390053701983964 0.693922735248958 0.46875 7.2 7 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.400006471259434 0.515458289355213 0.690838634203407 0.466666666666667 7.2 7 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.400006471259434 0.515458289355213 0.690838634203407 0.466666666666667 7.2 7 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0792894690227097 0.130287430045399 0.688058599458122 0.464788732394366 7.2 7 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0827637812065942 0.13552688222898 0.687313947294206 0.464285714285714 7.2 7 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.338405538678854 0.455152250982996 0.683247000860513 0.461538461538462 7.2 7 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.248216956363774 0.351805506878137 0.680969510857644 0.46 7.2 7 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.102884604355169 0.160722395716653 0.680753398667591 0.45985401459854 7.2 7 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.2953748763147 0.407650908060285 0.680169311667447 0.459459459459459 7.2 7 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.361687099259167 0.473923335401285 0.678502230021204 0.458333333333333 7.2 7 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.121705000368247 0.189067920877746 0.674873875849967 0.455882352941176 7.2 7 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.387345738946649 0.50521813613298 0.672894773574747 0.454545454545455 7.2 7 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.475961359315481 0.592039348169519 0.672894773574747 0.454545454545455 7.2 7 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.475961359315481 0.592039348169519 0.672894773574747 0.454545454545455 7.2 7 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.475961359315481 0.592039348169519 0.672894773574747 0.454545454545455 7.2 7 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.475961359315481 0.592039348169519 0.672894773574747 0.454545454545455 7.2 7 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.475961359315481 0.592039348169519 0.672894773574747 0.454545454545455 7.2 7 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.475961359315481 0.592039348169519 0.672894773574747 0.454545454545455 7.2 7 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.137263194405725 0.21254137719189 0.669947789164931 0.452554744525547 7.2 7 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.447544205589003 0.5665973350117 0.657941556384197 0.444444444444444 7.2 7 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.400309608373107 0.515458289355213 0.657941556384197 0.444444444444444 7.2 7 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.410401529164067 0.523670873981818 0.647661219565694 0.4375 7.2 7 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.483292186910148 0.600632997356454 0.647661219565694 0.4375 7.2 7 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.229461223508274 0.327505838567978 0.640159352157597 0.432432432432432 7.2 7 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.462660193836904 0.579547056188305 0.63444364365619 0.428571428571429 7.2 7 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.523953600160029 0.640010458798669 0.63444364365619 0.428571428571429 7.2 7 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.523953600160029 0.640010458798669 0.63444364365619 0.428571428571429 7.2 7 2 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.523953600160029 0.640010458798669 0.63444364365619 0.428571428571429 7.2 7 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.523953600160029 0.640010458798669 0.63444364365619 0.428571428571429 7.2 7 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.523953600160029 0.640010458798669 0.63444364365619 0.428571428571429 7.2 7 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.523953600160029 0.640010458798669 0.63444364365619 0.428571428571429 7.2 7 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.467811969650733 0.58497050335061 0.628035122003097 0.424242424242424 7.2 7 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.467811969650733 0.58497050335061 0.628035122003097 0.424242424242424 7.2 7 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.37446366801365 0.489360822492641 0.626309750788803 0.423076923076923 7.2 7 2 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.570799986945599 0.68602059241857 0.616820209110185 0.416666666666667 7.2 7 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.570799986945599 0.68602059241857 0.616820209110185 0.416666666666667 7.2 7 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.562826754013564 0.677582462742218 0.609563500767712 0.411764705882353 7.2 7 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.524811861809281 0.640010458798669 0.607330667431567 0.41025641025641 7.2 7 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.506315248721559 0.628148734900417 0.606708402403461 0.409836065573771 7.2 7 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.55496333261329 0.668681475282567 0.603113093352181 0.407407407407407 7.2 7 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.499290487035966 0.619974138788988 0.597202317581412 0.403414634146341 7.2 7 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.53732279751886 0.647974865143507 0.595758055628374 0.402439024390244 7.2 7 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.582893481981603 0.699964071611663 0.592147400745778 0.4 7.2 7 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.588125640487705 0.701511136977372 0.592147400745778 0.4 7.2 7 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.606585019427093 0.722923352298788 0.592147400745778 0.4 7.2 7 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.639451630386461 0.749690607436508 0.574020439498458 0.387755102040816 7.2 7 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.648231503433336 0.754238290585149 0.569372500717094 0.384615384615385 7.2 7 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.655705056975393 0.762310699408484 0.569372500717094 0.384615384615385 7.2 7 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.68056071893726 0.782892403433889 0.555138188199166 0.375 7.2 7 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.817071121888873 0.904115246071436 0.538315818859798 0.363636363636364 7.2 7 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.728900310761706 0.831776377076109 0.528703036380159 0.357142857142857 7.2 7 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.765864292303628 0.869473050250658 0.525292049048674 0.354838709677419 7.2 7 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.841085131851768 0.927082991963646 0.524687570281069 0.354430379746835 7.2 7 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.815273788114009 0.902828482868666 0.507554914924952 0.342857142857143 7.2 7 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.84776936663438 0.932284241669802 0.503955234677258 0.340425531914894 7.2 7 2 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.79907468001977 0.885578870458047 0.493456167288148 0.333333333333333 7.2 7 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.832784306332332 0.920786377553154 0.493456167288148 0.333333333333333 7.2 7 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.864650979679335 0.948649455731452 0.477538226407885 0.32258064516129 7.2 7 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.864650979679335 0.948649455731452 0.477538226407885 0.32258064516129 7.2 7 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.990568451274886 1 0.477538226407885 0.32258064516129 7.2 7 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.915326349833336 0.989748781012794 0.474835179843312 0.320754716981132 7.2 7 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.854006655732908 0.938418124407667 0.473717920596622 0.32 7.2 7 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.843940862548878 0.928791838675216 0.467484790062456 0.315789473684211 7.2 7 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.843940862548878 0.928791838675216 0.467484790062456 0.315789473684211 7.2 7 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.894913646822493 0.971323442869038 0.465258672014539 0.314285714285714 7.2 7 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.959600666199589 1 0.458705732972081 0.309859154929577 7.2 7 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99999559523242 1 0.438769014727863 0.29639175257732 7.2 7 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.947229904775775 1 0.428527724223918 0.289473684210526 7.2 7 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999884362349884 1 0.422962429104127 0.285714285714286 7.2 7 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.958959355446678 1 0.403736864144848 0.272727272727273 7.2 7 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999998605737416 1 0.40181430764892 0.271428571428571 7.2 7 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.959642709661857 1 0.394764933830518 0.266666666666667 7.2 7 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.968682745135962 1 0.391862250493529 0.264705882352941 7.2 7 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.951980733987457 1 0.370092125466111 0.25 7.2 7 2 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.951980733987457 1 0.370092125466111 0.25 7.2 7 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.965351846651148 1 0.352468690920106 0.238095238095238 7.2 7 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999899064575 1 0.328036202117689 0.221590909090909 7.2 7 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.989810138236642 1 0.317221821828095 0.214285714285714 7.2 7 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.313226584777363 0.211586901763224 7.2 7 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999997026845724 1 0.30155654667609 0.203703703703704 7.2 7 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.999610513397457 1 0.277569094099583 0.1875 7.2 7 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.99999883902962 1 0.263176622553679 0.177777777777778 7.2 7 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.262343785140534 0.177215189873418 7.2 7 2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.999084049940014 1 0.238769113203943 0.161290322580645 7.2 7 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999974961461166 1 0.215887073188565 0.145833333333333 7.2 7 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.999992546825144 1 0.188983213003972 0.127659574468085 7.2 7 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0143261467922366 0.00967741935483871 7.2 7 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00011052503534915 0.000504093350326412 2.67381416504224 1 8.2 8 2 S6K1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605159 S6K1 SIGNALLING 0.00149304090530529 0.00494092374011495 2.67381416504224 1 8.2 8 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.00149304090530529 0.00494092374011495 2.67381416504224 1 8.2 8 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 1.84215796728234e-05 0.000100053083490182 2.4307401500384 0.909090909090909 8.2 8 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000205177644514716 0.000861759355213733 2.37672370225976 0.888888888888889 8.2 8 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.000205177644514716 0.000861759355213733 2.37672370225976 0.888888888888889 8.2 8 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 8.13560082483871e-07 5.674980379287e-06 2.33958739441196 0.875 8.2 8 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.000673724665605175 0.00242711442824345 2.33958739441196 0.875 8.2 8 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000673724665605175 0.00242711442824345 2.33958739441196 0.875 8.2 8 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 5.15248516721334e-11 1.11090702923403e-09 2.30501221124331 0.862068965517241 8.2 8 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.00218053390611135 0.00680460471139573 2.29184071289334 0.857142857142857 8.2 8 2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.00218053390611135 0.00680460471139573 2.29184071289334 0.857142857142857 8.2 8 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00218053390611135 0.00680460471139573 2.29184071289334 0.857142857142857 8.2 8 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 5.1818919676043e-10 8.65726271785264e-09 2.27769354799894 0.851851851851852 8.2 8 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 1.14595506641672e-07 9.94325646043286e-07 2.2727420402859 0.85 8.2 8 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 1.14595506641672e-07 9.94325646043286e-07 2.2727420402859 0.85 8.2 8 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 1.11841374350597e-06 7.54266709482934e-06 2.22817847086853 0.833333333333333 8.2 8 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 8.32744469942294e-05 0.000394998460242628 2.22817847086853 0.833333333333333 8.2 8 2 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00692704249025586 0.0178572127964386 2.22817847086853 0.833333333333333 8.2 8 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00692704249025586 0.0178572127964386 2.22817847086853 0.833333333333333 8.2 8 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00692704249025586 0.0178572127964386 2.22817847086853 0.833333333333333 8.2 8 2 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.00692704249025586 0.0178572127964386 2.22817847086853 0.833333333333333 8.2 8 2 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 48%5604594 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION 0.00692704249025586 0.0178572127964386 2.22817847086853 0.833333333333333 8.2 8 2 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00692704249025586 0.0178572127964386 2.22817847086853 0.833333333333333 8.2 8 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 3.44380460128404e-06 2.09424527676375e-05 2.20196460650537 0.823529411764706 8.2 8 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 5.8517192236698e-08 5.45404755977898e-07 2.13905133203379 0.8 8.2 8 2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.000778810996606931 0.00272967499549671 2.13905133203379 0.8 8.2 8 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.000778810996606931 0.00272967499549671 2.13905133203379 0.8 8.2 8 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000778810996606931 0.00272967499549671 2.13905133203379 0.8 8.2 8 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.000778810996606931 0.00272967499549671 2.13905133203379 0.8 8.2 8 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.000778810996606931 0.00272967499549671 2.13905133203379 0.8 8.2 8 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.000778810996606931 0.00272967499549671 2.13905133203379 0.8 8.2 8 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 3.96394157601976e-06 2.39012239943903e-05 2.11090591977019 0.789473684210526 8.2 8 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 9.33984221669367e-05 0.00043575722866738 2.1008539868189 0.785714285714286 8.2 8 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 6.54375888218807e-08 5.9572373150145e-07 2.07963323947729 0.777777777777778 8.2 8 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00231363923942178 0.00711081779200257 2.07963323947729 0.777777777777778 8.2 8 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00231363923942178 0.00711081779200257 2.07963323947729 0.777777777777778 8.2 8 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.00231363923942178 0.00711081779200257 2.07963323947729 0.777777777777778 8.2 8 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00231363923942178 0.00711081779200257 2.07963323947729 0.777777777777778 8.2 8 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000272126486205231 0.00108774154457878 2.05678012695557 0.769230769230769 8.2 8 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000272126486205231 0.00108774154457878 2.05678012695557 0.769230769230769 8.2 8 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 4.19398510508309e-06 2.51816067701824e-05 2.03719174479408 0.761904761904762 8.2 8 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 1.50677782609512e-06 9.79061573759525e-06 2.00536062378168 0.75 8.2 8 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 1.50677782609512e-06 9.79061573759525e-06 2.00536062378168 0.75 8.2 8 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 1.50677782609512e-06 9.79061573759525e-06 2.00536062378168 0.75 8.2 8 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 1.50677782609512e-06 9.79061573759525e-06 2.00536062378168 0.75 8.2 8 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 9.46342376658002e-05 0.000438646645597504 2.00536062378168 0.75 8.2 8 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 9.46342376658002e-05 0.000438646645597504 2.00536062378168 0.75 8.2 8 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000777512967723064 0.00272967499549671 2.00536062378168 0.75 8.2 8 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000777512967723064 0.00272967499549671 2.00536062378168 0.75 8.2 8 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00670096162762987 0.0174962722864538 2.00536062378168 0.75 8.2 8 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00670096162762987 0.0174962722864538 2.00536062378168 0.75 8.2 8 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 2.11125572337582e-11 5.17985671442034e-10 1.99113820801018 0.74468085106383 8.2 8 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.92323557706298e-07 1.60986130950625e-06 1.96079705436431 0.733333333333333 8.2 8 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.000263556393839372 0.00106545667168587 1.96079705436431 0.733333333333333 8.2 8 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.47856698257204e-06 9.78605030790707e-06 1.95394112060779 0.730769230769231 8.2 8 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.00217074944842159 0.00680460471139573 1.94459212003072 0.727272727272727 8.2 8 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00217074944842159 0.00680460471139573 1.94459212003072 0.727272727272727 8.2 8 2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.00217074944842159 0.00680460471139573 1.94459212003072 0.727272727272727 8.2 8 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00217074944842159 0.00680460471139573 1.94459212003072 0.727272727272727 8.2 8 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00217074944842159 0.00680460471139573 1.94459212003072 0.727272727272727 8.2 8 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000718946646300966 0.00258348756991483 1.90986726074445 0.714285714285714 8.2 8 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0187933139506171 0.04224784478946 1.90986726074445 0.714285714285714 8.2 8 2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0187933139506171 0.04224784478946 1.90986726074445 0.714285714285714 8.2 8 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0187933139506171 0.04224784478946 1.90986726074445 0.714285714285714 8.2 8 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.0187933139506171 0.04224784478946 1.90986726074445 0.714285714285714 8.2 8 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0187933139506171 0.04224784478946 1.90986726074445 0.714285714285714 8.2 8 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0187933139506171 0.04224784478946 1.90986726074445 0.714285714285714 8.2 8 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0187933139506171 0.04224784478946 1.90986726074445 0.714285714285714 8.2 8 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 8.17127540713986e-09 1.04754278417658e-07 1.89123440942012 0.707317073170732 8.2 8 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 8.17127540713986e-09 1.04754278417658e-07 1.89123440942012 0.707317073170732 8.2 8 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00024166446499989 0.000985353964741672 1.88739823414746 0.705882352941177 8.2 8 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 3.71007009616251e-06 2.24656584971883e-05 1.88157293095565 0.703703703703704 8.2 8 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 6.07176119051334e-08 5.61046504811719e-07 1.87889644029995 0.702702702702703 8.2 8 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 6.30153837309974e-12 1.66057205646684e-10 1.87166991552956 0.7 8.2 8 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 6.30153837309974e-12 1.66057205646684e-10 1.87166991552956 0.7 8.2 8 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 6.30153837309974e-12 1.66057205646684e-10 1.87166991552956 0.7 8.2 8 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 6.30153837309974e-12 1.66057205646684e-10 1.87166991552956 0.7 8.2 8 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 6.30153837309974e-12 1.66057205646684e-10 1.87166991552956 0.7 8.2 8 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 6.30153837309974e-12 1.66057205646684e-10 1.87166991552956 0.7 8.2 8 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 6.30153837309974e-12 1.66057205646684e-10 1.87166991552956 0.7 8.2 8 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 1.29201713179749e-06 8.61115071278051e-06 1.87166991552956 0.7 8.2 8 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0058949051393231 0.0158272641759562 1.87166991552956 0.7 8.2 8 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0058949051393231 0.0158272641759562 1.87166991552956 0.7 8.2 8 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0058949051393231 0.0158272641759562 1.87166991552956 0.7 8.2 8 2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.0058949051393231 0.0158272641759562 1.87166991552956 0.7 8.2 8 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 4.51297384779046e-07 3.19500586338598e-06 1.86356744836277 0.696969696969697 8.2 8 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.81128641402512e-05 0.000146002210480209 1.86004463655112 0.695652173913043 8.2 8 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00191463255113818 0.00617805469448896 1.85110211426001 0.692307692307692 8.2 8 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.00191463255113818 0.00617805469448896 1.85110211426001 0.692307692307692 8.2 8 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00191463255113818 0.00617805469448896 1.85110211426001 0.692307692307692 8.2 8 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.18164109339793e-14 6.00526884251878e-13 1.83824723846654 0.6875 8.2 8 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000635185137421232 0.00230578686364901 1.83824723846654 0.6875 8.2 8 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000635185137421232 0.00230578686364901 1.83824723846654 0.6875 8.2 8 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000635185137421232 0.00230578686364901 1.83824723846654 0.6875 8.2 8 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.000213756632909962 0.000889402598335893 1.82945179713416 0.684210526315789 8.2 8 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.000213756632909962 0.000889402598335893 1.82945179713416 0.684210526315789 8.2 8 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.98815296223768e-08 4.76142314429071e-07 1.82601942978494 0.682926829268293 8.2 8 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.98815296223768e-08 4.76142314429071e-07 1.82601942978494 0.682926829268293 8.2 8 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 8.58465721445964e-06 4.88638688647043e-05 1.81437389770723 0.678571428571429 8.2 8 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 8.58465721445964e-06 4.88638688647043e-05 1.81437389770723 0.678571428571429 8.2 8 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 8.58465721445964e-06 4.88638688647043e-05 1.81437389770723 0.678571428571429 8.2 8 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 1.03411198556974e-06 7.04086772950116e-06 1.80875664105798 0.676470588235294 8.2 8 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 3.60798949123798e-07 2.6306520232179e-06 1.8066311925961 0.675675675675676 8.2 8 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 3.88363319601427e-08 3.83778474856133e-07 1.78254277669482 0.666666666666667 8.2 8 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 7.47795460895225e-06 4.34331812593431e-05 1.78254277669482 0.666666666666667 8.2 8 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00162972715122416 0.00533126835906201 1.78254277669482 0.666666666666667 8.2 8 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00162972715122416 0.00533126835906201 1.78254277669482 0.666666666666667 8.2 8 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00162972715122416 0.00533126835906201 1.78254277669482 0.666666666666667 8.2 8 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.00162972715122416 0.00533126835906201 1.78254277669482 0.666666666666667 8.2 8 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00162972715122416 0.00533126835906201 1.78254277669482 0.666666666666667 8.2 8 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000184405674472714 0.000791679288867963 1.78254277669482 0.666666666666667 8.2 8 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000184405674472714 0.000791679288867963 1.78254277669482 0.666666666666667 8.2 8 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.36580902551936e-08 1.61962186942837e-07 1.78254277669482 0.666666666666667 8.2 8 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 9.04083806937152e-07 6.2756646696174e-06 1.78254277669482 0.666666666666667 8.2 8 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 6.29551156257767e-05 0.000308914239777518 1.78254277669482 0.666666666666667 8.2 8 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00495722240981863 0.0136707897076975 1.78254277669482 0.666666666666667 8.2 8 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0154756064040461 0.0358661040927648 1.78254277669482 0.666666666666667 8.2 8 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 5.23207725745135e-10 8.65726271785264e-09 1.76743648197707 0.661016949152542 8.2 8 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 5.23207725745135e-10 8.65726271785264e-09 1.76743648197707 0.661016949152542 8.2 8 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 2.73468787854028e-07 2.21105730179705e-06 1.76080445014976 0.658536585365854 8.2 8 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 2.73468787854028e-07 2.21105730179705e-06 1.76080445014976 0.658536585365854 8.2 8 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 2.73468787854028e-07 2.21105730179705e-06 1.76080445014976 0.658536585365854 8.2 8 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 2.73468787854028e-07 2.21105730179705e-06 1.76080445014976 0.658536585365854 8.2 8 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 2.73468787854028e-07 2.21105730179705e-06 1.76080445014976 0.658536585365854 8.2 8 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 5.69626449601511e-11 1.19202711438669e-09 1.75593766062475 0.656716417910448 8.2 8 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 5.69626449601511e-11 1.19202711438669e-09 1.75593766062475 0.656716417910448 8.2 8 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 5.36456195599341e-05 0.000265985075379046 1.74826310791223 0.653846153846154 8.2 8 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 5.36456195599341e-05 0.000265985075379046 1.74826310791223 0.653846153846154 8.2 8 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 6.2091174487787e-12 1.66057205646684e-10 1.74689192116093 0.653333333333333 8.2 8 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00015623816705931 0.000690456247594404 1.74379184676668 0.652173913043478 8.2 8 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000458265849533784 0.00171608501022783 1.73797920727745 0.65 8.2 8 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000458265849533784 0.00171608501022783 1.73797920727745 0.65 8.2 8 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000458265849533784 0.00171608501022783 1.73797920727745 0.65 8.2 8 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.48457310761681e-08 2.54355937563937e-07 1.73011504796851 0.647058823529412 8.2 8 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.48457310761681e-08 2.54355937563937e-07 1.73011504796851 0.647058823529412 8.2 8 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00135663970352702 0.00453168614581913 1.73011504796851 0.647058823529412 8.2 8 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.00135663970352702 0.00453168614581913 1.73011504796851 0.647058823529412 8.2 8 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.99505755928665e-07 1.66021456541808e-06 1.72312468413833 0.644444444444444 8.2 8 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.60771002040528e-11 7.89810978313341e-10 1.72149679119158 0.643835616438356 8.2 8 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00406686717984517 0.011551201590658 1.71888053467001 0.642857142857143 8.2 8 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.00406686717984517 0.011551201590658 1.71888053467001 0.642857142857143 8.2 8 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00406686717984517 0.011551201590658 1.71888053467001 0.642857142857143 8.2 8 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00406686717984517 0.011551201590658 1.71888053467001 0.642857142857143 8.2 8 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00406686717984517 0.011551201590658 1.71888053467001 0.642857142857143 8.2 8 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.84643556348413e-10 5.32957606162885e-09 1.71602998651964 0.641791044776119 8.2 8 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 3.06831824289285e-11 6.82221384318208e-10 1.71124106562703 0.64 8.2 8 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 3.06831824289285e-11 6.82221384318208e-10 1.71124106562703 0.64 8.2 8 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 3.06831824289285e-11 6.82221384318208e-10 1.71124106562703 0.64 8.2 8 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 3.06831824289285e-11 6.82221384318208e-10 1.71124106562703 0.64 8.2 8 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 3.06831824289285e-11 6.82221384318208e-10 1.71124106562703 0.64 8.2 8 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000130603214045894 0.00058755757244848 1.71124106562703 0.64 8.2 8 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000130603214045894 0.00058755757244848 1.71124106562703 0.64 8.2 8 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.18597837883258e-12 4.11621276360674e-11 1.70999743113166 0.63953488372093 8.2 8 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 4.59415415992555e-06 2.72605652709773e-05 1.70827016099921 0.638888888888889 8.2 8 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.00529171418595e-12 3.66802592124771e-11 1.70151810502688 0.636363636363636 8.2 8 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0124121775984007 0.0299873153183773 1.70151810502688 0.636363636363636 8.2 8 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0124121775984007 0.0299873153183773 1.70151810502688 0.636363636363636 8.2 8 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.0124121775984007 0.0299873153183773 1.70151810502688 0.636363636363636 8.2 8 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0124121775984007 0.0299873153183773 1.70151810502688 0.636363636363636 8.2 8 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0124121775984007 0.0299873153183773 1.70151810502688 0.636363636363636 8.2 8 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0124121775984007 0.0299873153183773 1.70151810502688 0.636363636363636 8.2 8 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 5.01906866931557e-08 4.76142314429071e-07 1.69684360473834 0.634615384615385 8.2 8 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 2.36912824615172e-12 7.84016161459046e-11 1.69034228824509 0.632183908045977 8.2 8 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 8.42766726807823e-15 4.49203897023948e-13 1.683512622434 0.62962962962963 8.2 8 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000108056713887803 0.000494420269653839 1.683512622434 0.62962962962963 8.2 8 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 9.98748226308113e-17 7.10609363018222e-15 1.68191536188141 0.629032258064516 8.2 8 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 9.98748226308113e-17 7.10609363018222e-15 1.68191536188141 0.629032258064516 8.2 8 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 9.98748226308113e-17 7.10609363018222e-15 1.68191536188141 0.629032258064516 8.2 8 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.33550093882459e-09 2.00043982731304e-08 1.67612231241454 0.626865671641791 8.2 8 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 3.18457181057144e-06 1.94491231177818e-05 1.6711338531514 0.625 8.2 8 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 3.18457181057144e-06 1.94491231177818e-05 1.6711338531514 0.625 8.2 8 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00328729717422903 0.00972520556949669 1.6711338531514 0.625 8.2 8 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00328729717422903 0.00972520556949669 1.6711338531514 0.625 8.2 8 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.00328729717422903 0.00972520556949669 1.6711338531514 0.625 8.2 8 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00328729717422903 0.00972520556949669 1.6711338531514 0.625 8.2 8 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00328729717422903 0.00972520556949669 1.6711338531514 0.625 8.2 8 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00328729717422903 0.00972520556949669 1.6711338531514 0.625 8.2 8 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00328729717422903 0.00972520556949669 1.6711338531514 0.625 8.2 8 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.0389472344889292 0.0757129981936425 1.6711338531514 0.625 8.2 8 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 4.9564815164097e-15 2.8212292791404e-13 1.66527022559648 0.62280701754386 8.2 8 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 4.1977886357423e-13 1.70670092247466e-11 1.66431289864874 0.622448979591837 8.2 8 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 9.34105720421003e-07 6.45258466096644e-06 1.66370659158184 0.622222222222222 8.2 8 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.16370294936132e-12 4.11621276360674e-11 1.66057932355255 0.621052631578947 8.2 8 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 8.86875319014976e-05 0.000417888602304077 1.65960879209518 0.620689655172414 8.2 8 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 3.49694348209372e-13 1.46357369853511e-11 1.65776478232619 0.62 8.2 8 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.70638705324903e-07 5.40206343683417e-06 1.64980022949415 0.617021276595745 8.2 8 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00025373536522343 0.00103161549917983 1.64542410156445 0.615384615384615 8.2 8 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00982536618370732 0.0243580071069957 1.64542410156445 0.615384615384615 8.2 8 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00982536618370732 0.0243580071069957 1.64542410156445 0.615384615384615 8.2 8 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00982536618370732 0.0243580071069957 1.64542410156445 0.615384615384615 8.2 8 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00982536618370732 0.0243580071069957 1.64542410156445 0.615384615384615 8.2 8 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.58831066153039e-16 1.6741663960717e-14 1.64542410156445 0.615384615384615 8.2 8 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.15900459656535e-06 1.36545046262778e-05 1.64074960127592 0.613636363636364 8.2 8 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 2.15900459656535e-06 1.36545046262778e-05 1.64074960127592 0.613636363636364 8.2 8 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 2.15900459656535e-06 1.36545046262778e-05 1.64074960127592 0.613636363636364 8.2 8 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 7.23277660808823e-05 0.000346540104825238 1.63878932696137 0.612903225806452 8.2 8 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 5.98815460180542e-14 2.8403813327897e-12 1.63801228128714 0.612612612612613 8.2 8 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 1.86415742103496e-07 1.56964260954601e-06 1.63399754530359 0.611111111111111 8.2 8 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.75167327492928e-09 2.49263107022437e-08 1.63399754530359 0.611111111111111 8.2 8 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.08336625675614e-05 0.000111034838328239 1.63399754530359 0.611111111111111 8.2 8 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00263215608095368 0.00802046703040062 1.63399754530359 0.611111111111111 8.2 8 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00263215608095368 0.00802046703040062 1.63399754530359 0.611111111111111 8.2 8 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00263215608095368 0.00802046703040062 1.63399754530359 0.611111111111111 8.2 8 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 5.04968675519562e-12 1.56210962013986e-10 1.63243391128894 0.610526315789474 8.2 8 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 5.04968675519562e-12 1.56210962013986e-10 1.63243391128894 0.610526315789474 8.2 8 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.63086284976095e-08 1.91794862414036e-07 1.62935550682261 0.609375 8.2 8 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 4.84111917650778e-09 6.43823606371081e-08 1.62753905698223 0.608695652173913 8.2 8 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 4.28897980099312e-10 7.44294909367465e-09 1.62459594838009 0.607594936708861 8.2 8 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 4.28897980099312e-10 7.44294909367465e-09 1.62459594838009 0.607594936708861 8.2 8 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.28897980099312e-10 7.44294909367465e-09 1.62459594838009 0.607594936708861 8.2 8 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.00020529614997713 0.000861759355213733 1.62338717163279 0.607142857142857 8.2 8 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00020529614997713 0.000861759355213733 1.62338717163279 0.607142857142857 8.2 8 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 5.86836793180429e-05 0.000289954429408247 1.62049343335893 0.606060606060606 8.2 8 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 1.69379132780952e-05 9.27025022874208e-05 1.61836120515714 0.605263157894737 8.2 8 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.51762721461158e-10 6.417414777426e-09 1.61749251959345 0.604938271604938 8.2 8 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.51762721461158e-10 6.417414777426e-09 1.61749251959345 0.604938271604938 8.2 8 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 4.88317095461293e-24 8.99267142225979e-22 1.6170209474303 0.604761904761905 8.2 8 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 9.66029449893155e-10 1.51061528263512e-08 1.61114443278186 0.602564102564103 8.2 8 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 6.63937137830157e-25 1.57463757855385e-22 1.60668653863524 0.600896860986547 8.2 8 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.35200608682587e-10 4.52284413723406e-09 1.60428849902534 0.6 8.2 8 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 3.00521851485958e-08 3.01156756805998e-07 1.60428849902534 0.6 8.2 8 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.00209435915736448 0.00665239526993227 1.60428849902534 0.6 8.2 8 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00209435915736448 0.00665239526993227 1.60428849902534 0.6 8.2 8 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00209435915736448 0.00665239526993227 1.60428849902534 0.6 8.2 8 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.00772257722277671 0.0195537853879204 1.60428849902534 0.6 8.2 8 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00772257722277671 0.0195537853879204 1.60428849902534 0.6 8.2 8 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00772257722277671 0.0195537853879204 1.60428849902534 0.6 8.2 8 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00772257722277671 0.0195537853879204 1.60428849902534 0.6 8.2 8 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0298466583011306 0.0612868611291613 1.60428849902534 0.6 8.2 8 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.62861707085357e-13 2.22486724772906e-11 1.60428849902534 0.6 8.2 8 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 4.74143830720121e-05 0.00023841225127729 1.60428849902534 0.6 8.2 8 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000583369977552488 0.00213952442798245 1.60428849902534 0.6 8.2 8 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000583369977552488 0.00213952442798245 1.60428849902534 0.6 8.2 8 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 3.8177017950529e-05 0.000192645023204265 1.58983544948457 0.594594594594595 8.2 8 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 3.8177017950529e-05 0.000192645023204265 1.58983544948457 0.594594594594595 8.2 8 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.98415967059778e-08 2.10705911288108e-07 1.58878812705408 0.594202898550725 8.2 8 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000132623700520181 0.000593470207044708 1.58757716049383 0.59375 8.2 8 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.42459763698836e-09 2.11166920566087e-08 1.58448246817318 0.592592592592593 8.2 8 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.000465631585347977 0.0017345386019638 1.58448246817318 0.592592592592593 8.2 8 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000465631585347977 0.0017345386019638 1.58448246817318 0.592592592592593 8.2 8 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 2.60979480652993e-06 1.63600793378506e-05 1.58246144461683 0.591836734693878 8.2 8 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00165925287084795 0.00540301335289848 1.57998109752496 0.590909090909091 8.2 8 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00165925287084795 0.00540301335289848 1.57998109752496 0.590909090909091 8.2 8 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 3.19657302620634e-22 3.99669516167042e-20 1.57882360221542 0.59047619047619 8.2 8 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 9.3452721393354e-10 1.47759136158603e-08 1.57283186178955 0.588235294117647 8.2 8 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 4.37507196218418e-08 4.23518870897149e-07 1.57283186178955 0.588235294117647 8.2 8 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 2.1016515890733e-06 1.34713973479789e-05 1.57283186178955 0.588235294117647 8.2 8 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000106072557839235 0.000488483009078419 1.57283186178955 0.588235294117647 8.2 8 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0060453792752319 0.0161096904656461 1.57283186178955 0.588235294117647 8.2 8 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0060453792752319 0.0161096904656461 1.57283186178955 0.588235294117647 8.2 8 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0060453792752319 0.0161096904656461 1.57283186178955 0.588235294117647 8.2 8 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0060453792752319 0.0161096904656461 1.57283186178955 0.588235294117647 8.2 8 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.47489334353814e-07 1.25675043584118e-06 1.57033530327877 0.587301587301587 8.2 8 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000370491692250941 0.00143349959836956 1.56740830364545 0.586206896551724 8.2 8 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000370491692250941 0.00143349959836956 1.56740830364545 0.586206896551724 8.2 8 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.18790929371508e-07 1.02448177270094e-06 1.56315289648623 0.584615384615385 8.2 8 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 2.84250806343224e-08 2.88920641018863e-07 1.55972492960797 0.583333333333333 8.2 8 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00131054679252056 0.00439836812678481 1.55972492960797 0.583333333333333 8.2 8 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0228491148624157 0.0483211639043322 1.55972492960797 0.583333333333333 8.2 8 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0228491148624157 0.0483211639043322 1.55972492960797 0.583333333333333 8.2 8 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0228491148624157 0.0483211639043322 1.55972492960797 0.583333333333333 8.2 8 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0228491148624157 0.0483211639043322 1.55972492960797 0.583333333333333 8.2 8 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0228491148624157 0.0483211639043322 1.55972492960797 0.583333333333333 8.2 8 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0228491148624157 0.0483211639043322 1.55972492960797 0.583333333333333 8.2 8 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0228491148624157 0.0483211639043322 1.55972492960797 0.583333333333333 8.2 8 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.64220414868595e-09 2.36046111472737e-08 1.5545431192106 0.581395348837209 8.2 8 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.64220414868595e-09 2.36046111472737e-08 1.5545431192106 0.581395348837209 8.2 8 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 2.2865037078608e-08 2.37495969071965e-07 1.55370282563265 0.581081081081081 8.2 8 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 2.2865037078608e-08 2.37495969071965e-07 1.55370282563265 0.581081081081081 8.2 8 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 3.21700354990385e-07 2.55742796173921e-06 1.5525372571213 0.580645161290323 8.2 8 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000294073654313428 0.00116564571055156 1.5525372571213 0.580645161290323 8.2 8 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000294073654313428 0.00116564571055156 1.5525372571213 0.580645161290323 8.2 8 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 3.96069756567711e-10 7.13426915944117e-09 1.5525372571213 0.580645161290323 8.2 8 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 4.59770601899828e-06 2.72605652709773e-05 1.5508122157245 0.58 8.2 8 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.00472140382984916 0.0133040745542086 1.54799767449814 0.578947368421053 8.2 8 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00472140382984916 0.0133040745542086 1.54799767449814 0.578947368421053 8.2 8 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00103287172163756 0.00355018468572525 1.54258509521667 0.576923076923077 8.2 8 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000232970872151654 0.000958143211190184 1.53946876169098 0.575757575757576 8.2 8 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.44637458224787e-16 4.6070395784951e-14 1.53744314489929 0.575 8.2 8 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 5.35586285425179e-05 0.000265985075379046 1.53744314489929 0.575 8.2 8 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 9.46651470076443e-09 1.20275450171319e-07 1.53255202142665 0.573170731707317 8.2 8 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.56738503900898e-11 6.19218459408437e-10 1.52789380859556 0.571428571428571 8.2 8 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 9.92464298406273e-06 5.60427260568304e-05 1.52789380859556 0.571428571428571 8.2 8 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0175033648555235 0.0398516611030559 1.52789380859556 0.571428571428571 8.2 8 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0175033648555235 0.0398516611030559 1.52789380859556 0.571428571428571 8.2 8 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0175033648555235 0.0398516611030559 1.52789380859556 0.571428571428571 8.2 8 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0175033648555235 0.0398516611030559 1.52789380859556 0.571428571428571 8.2 8 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0175033648555235 0.0398516611030559 1.52789380859556 0.571428571428571 8.2 8 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0175033648555235 0.0398516611030559 1.52789380859556 0.571428571428571 8.2 8 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00368245318850641 0.0106941446678462 1.52789380859556 0.571428571428571 8.2 8 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00368245318850641 0.0106941446678462 1.52789380859556 0.571428571428571 8.2 8 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00368245318850641 0.0106941446678462 1.52789380859556 0.571428571428571 8.2 8 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 6.80208180012412e-11 1.38276605736809e-09 1.52088512140017 0.568807339449541 8.2 8 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 6.69777472921379e-08 6.0322363542223e-07 1.51281590916863 0.565789473684211 8.2 8 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 2.66940727683425e-05 0.000139653182166733 1.51128626719779 0.565217391304348 8.2 8 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 2.66940727683425e-05 0.000139653182166733 1.51128626719779 0.565217391304348 8.2 8 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00287002206808651 0.00865263009086252 1.51128626719779 0.565217391304348 8.2 8 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00287002206808651 0.00865263009086252 1.51128626719779 0.565217391304348 8.2 8 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00287002206808651 0.00865263009086252 1.51128626719779 0.565217391304348 8.2 8 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 2.15467785509121e-16 1.46005075609276e-14 1.51062947177527 0.564971751412429 8.2 8 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 1.28084984263539e-08 1.54461807294082e-07 1.50991858731797 0.564705882352941 8.2 8 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.28084984263539e-08 1.54461807294082e-07 1.50991858731797 0.564705882352941 8.2 8 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.28084984263539e-08 1.54461807294082e-07 1.50991858731797 0.564705882352941 8.2 8 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 1.28084984263539e-08 1.54461807294082e-07 1.50991858731797 0.564705882352941 8.2 8 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.28084984263539e-08 1.54461807294082e-07 1.50991858731797 0.564705882352941 8.2 8 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 1.17674018987035e-06 7.89859099144105e-06 1.50941122220126 0.564516129032258 8.2 8 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.88701786267717e-37 1.7385566046474e-34 1.50637417748858 0.563380281690141 8.2 8 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 5.0556128867237e-24 8.99267142225979e-22 1.50402046783626 0.5625 8.2 8 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.013425080142338 0.0318929700209466 1.50402046783626 0.5625 8.2 8 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.013425080142338 0.0318929700209466 1.50402046783626 0.5625 8.2 8 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.013425080142338 0.0318929700209466 1.50402046783626 0.5625 8.2 8 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.82551080626604e-23 1.07918909747962e-20 1.50144949267756 0.561538461538462 8.2 8 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 9.06263567494807e-05 0.000425614870146901 1.49994453160906 0.560975609756098 8.2 8 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 1.2425984220254e-09 1.90130919843242e-08 1.49733593242365 0.56 8.2 8 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00223604455702538 0.00694736114551774 1.49733593242365 0.56 8.2 8 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00223604455702538 0.00694736114551774 1.49733593242365 0.56 8.2 8 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.93938828746406e-12 2.2715624166181e-10 1.49480949384251 0.559055118110236 8.2 8 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.47836813712148e-44 2.47485892956193e-41 1.49448928616429 0.55893536121673 8.2 8 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000393708736947382 0.00150330505015379 1.49419026870007 0.558823529411765 8.2 8 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000393708736947382 0.00150330505015379 1.49419026870007 0.558823529411765 8.2 8 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000393708736947382 0.00150330505015379 1.49419026870007 0.558823529411765 8.2 8 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.11900646293703e-12 1.84188112668353e-10 1.49236139444218 0.558139534883721 8.2 8 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.32011084758501e-05 7.33795990669323e-05 1.49116559204279 0.557692307692308 8.2 8 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 8.86957425638486e-08 7.83938147008426e-07 1.48921295268175 0.556962025316456 8.2 8 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.58208064876006e-09 3.60225565018193e-08 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.69733242897807e-07 2.6306520232179e-06 1.48545231391235 0.555555555555556 8.2 8 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000308853539717145 0.00121408449452348 1.48545231391235 0.555555555555556 8.2 8 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00174192189199956 0.00565925765368805 1.48545231391235 0.555555555555556 8.2 8 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0103119082680797 0.0252997335611679 1.48545231391235 0.555555555555556 8.2 8 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0103119082680797 0.0252997335611679 1.48545231391235 0.555555555555556 8.2 8 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0103119082680797 0.0252997335611679 1.48545231391235 0.555555555555556 8.2 8 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0103119082680797 0.0252997335611679 1.48545231391235 0.555555555555556 8.2 8 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0103119082680797 0.0252997335611679 1.48545231391235 0.555555555555556 8.2 8 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0682867695950332 0.122382963644499 1.48545231391235 0.555555555555556 8.2 8 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0682867695950332 0.122382963644499 1.48545231391235 0.555555555555556 8.2 8 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0682867695950332 0.122382963644499 1.48545231391235 0.555555555555556 8.2 8 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0682867695950332 0.122382963644499 1.48545231391235 0.555555555555556 8.2 8 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0682867695950332 0.122382963644499 1.48545231391235 0.555555555555556 8.2 8 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 6.49646920960918e-06 3.78871954314503e-05 1.47520781519572 0.551724137931034 8.2 8 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 6.49646920960918e-06 3.78871954314503e-05 1.47520781519572 0.551724137931034 8.2 8 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 9.66450420159769e-07 6.61182186484303e-06 1.47253533726964 0.550724637681159 8.2 8 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 9.66450420159769e-07 6.61182186484303e-06 1.47253533726964 0.550724637681159 8.2 8 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000189902842889535 0.000806661926662116 1.47059779077323 0.55 8.2 8 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00793223620733044 0.0199780037575774 1.47059779077323 0.55 8.2 8 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00793223620733044 0.0199780037575774 1.47059779077323 0.55 8.2 8 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.00105738693497852 0.00362569062282997 1.46628518728123 0.548387096774194 8.2 8 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.64757819361172e-09 3.63873441345419e-08 1.46545584045584 0.548076923076923 8.2 8 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000148870025913197 0.000659944071260062 1.46423156657075 0.547619047619048 8.2 8 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.83746041732534e-18 3.21218010226703e-16 1.46280416204104 0.547085201793722 8.2 8 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 4.25381688687825e-15 2.52215892917823e-13 1.4611006366351 0.546448087431694 8.2 8 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.31358984735903e-09 1.98855143914032e-08 1.45844409002304 0.545454545454545 8.2 8 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.000824069719351315 0.00286012490399249 1.45844409002304 0.545454545454545 8.2 8 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000824069719351315 0.00286012490399249 1.45844409002304 0.545454545454545 8.2 8 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00611029356969655 0.0161616129176174 1.45844409002304 0.545454545454545 8.2 8 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00611029356969655 0.0161616129176174 1.45844409002304 0.545454545454545 8.2 8 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00611029356969655 0.0161616129176174 1.45844409002304 0.545454545454545 8.2 8 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00611029356969655 0.0161616129176174 1.45844409002304 0.545454545454545 8.2 8 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0507680351444063 0.0949315558613537 1.45844409002304 0.545454545454545 8.2 8 2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0507680351444063 0.0949315558613537 1.45844409002304 0.545454545454545 8.2 8 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0507680351444063 0.0949315558613537 1.45844409002304 0.545454545454545 8.2 8 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.0507680351444063 0.0949315558613537 1.45844409002304 0.545454545454545 8.2 8 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0507680351444063 0.0949315558613537 1.45844409002304 0.545454545454545 8.2 8 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0507680351444063 0.0949315558613537 1.45844409002304 0.545454545454545 8.2 8 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0507680351444063 0.0949315558613537 1.45844409002304 0.545454545454545 8.2 8 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0507680351444063 0.0949315558613537 1.45844409002304 0.545454545454545 8.2 8 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 9.14656078607736e-05 0.00042814328942724 1.45315987230556 0.543478260869565 8.2 8 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.27382885440822e-13 1.01114326869466e-11 1.45103329688268 0.542682926829268 8.2 8 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 3.36529785442293e-09 4.51775362909796e-08 1.44935721095747 0.542056074766355 8.2 8 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 7.16913558975402e-05 0.000344651349466891 1.44831600606454 0.541666666666667 8.2 8 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00471303830284629 0.0133040745542086 1.44831600606454 0.541666666666667 8.2 8 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.65937019676202e-09 3.63873441345419e-08 1.44729390584855 0.541284403669725 8.2 8 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.37725986886645e-14 6.75807170136885e-13 1.44648963026875 0.540983606557377 8.2 8 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 8.25341864310966e-06 4.77423362973376e-05 1.44648963026875 0.540983606557377 8.2 8 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 6.48846966196855e-06 3.78871954314503e-05 1.44301081922914 0.53968253968254 8.2 8 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 3.37036837245573e-22 3.99669516167042e-20 1.44185200708762 0.539249146757679 8.2 8 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00363974619831117 0.0106352337581043 1.4397460888689 0.538461538461538 8.2 8 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00363974619831117 0.0106352337581043 1.4397460888689 0.538461538461538 8.2 8 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00363974619831117 0.0106352337581043 1.4397460888689 0.538461538461538 8.2 8 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00363974619831117 0.0106352337581043 1.4397460888689 0.538461538461538 8.2 8 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00363974619831117 0.0106352337581043 1.4397460888689 0.538461538461538 8.2 8 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0380434883209088 0.0753981669646982 1.4397460888689 0.538461538461538 8.2 8 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0380434883209088 0.0753981669646982 1.4397460888689 0.538461538461538 8.2 8 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0380434883209088 0.0753981669646982 1.4397460888689 0.538461538461538 8.2 8 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000304854563683283 0.00120502234478142 1.43472955197388 0.536585365853659 8.2 8 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.93237651524155e-07 2.34425380965659e-06 1.43240044555834 0.535714285714286 8.2 8 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.93237651524155e-07 2.34425380965659e-06 1.43240044555834 0.535714285714286 8.2 8 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00281404849910391 0.00854683508477685 1.43240044555834 0.535714285714286 8.2 8 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.47717607200904e-06 1.55974404888003e-05 1.43105546861415 0.535211267605634 8.2 8 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.9290629274871e-12 9.47285578594123e-11 1.43057573161495 0.535031847133758 8.2 8 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.000237930650435654 0.000972917573476825 1.43017966967375 0.534883720930233 8.2 8 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.31316843568657e-12 7.83723496186187e-11 1.42939750961377 0.534591194968553 8.2 8 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.35226399088259e-08 1.61703500758481e-07 1.42603422135586 0.533333333333333 8.2 8 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.43088205062301e-07 1.22659346869671e-06 1.42603422135586 0.533333333333333 8.2 8 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 1.66376303046259e-05 9.14106097431763e-05 1.42603422135586 0.533333333333333 8.2 8 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.028681407864377 0.0598440518929743 1.42603422135586 0.533333333333333 8.2 8 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.028681407864377 0.0598440518929743 1.42603422135586 0.533333333333333 8.2 8 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.028681407864377 0.0598440518929743 1.42603422135586 0.533333333333333 8.2 8 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 1.30457944721507e-05 7.2800649152433e-05 1.42315915236119 0.532258064516129 8.2 8 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000145061968303699 0.000645072440300512 1.42224157715013 0.531914893617021 8.2 8 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 4.32406615663328e-08 4.21448365814326e-07 1.41712150747238 0.53 8.2 8 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00130822582455574 0.00439836812678481 1.4155486756106 0.529411764705882 8.2 8 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00130822582455574 0.00439836812678481 1.4155486756106 0.529411764705882 8.2 8 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0217272436178324 0.0464930340874819 1.4155486756106 0.529411764705882 8.2 8 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0217272436178324 0.0464930340874819 1.4155486756106 0.529411764705882 8.2 8 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0217272436178324 0.0464930340874819 1.4155486756106 0.529411764705882 8.2 8 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0217272436178324 0.0464930340874819 1.4155486756106 0.529411764705882 8.2 8 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0217272436178324 0.0464930340874819 1.4155486756106 0.529411764705882 8.2 8 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0217272436178324 0.0464930340874819 1.4155486756106 0.529411764705882 8.2 8 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0217272436178324 0.0464930340874819 1.4155486756106 0.529411764705882 8.2 8 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0217272436178324 0.0464930340874819 1.4155486756106 0.529411764705882 8.2 8 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.39420541377599e-18 1.23997143987702e-16 1.41374082289589 0.528735632183908 8.2 8 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 4.93596763713787e-06 2.91447383719801e-05 1.4133017729509 0.528571428571429 8.2 8 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 6.92038177983064e-05 0.000333820449922 1.4125810683242 0.528301886792453 8.2 8 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0010151898806248 0.00349785762743123 1.41117969821674 0.527777777777778 8.2 8 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 6.08789535107767e-10 9.84440350520856e-09 1.4083448655566 0.526717557251908 8.2 8 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 6.08789535107767e-10 9.84440350520856e-09 1.4083448655566 0.526717557251908 8.2 8 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 4.79485685780059e-10 8.22057988994005e-09 1.40727061318012 0.526315789473684 8.2 8 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0165235798661136 0.0379855478989977 1.40727061318012 0.526315789473684 8.2 8 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0165235798661136 0.0379855478989977 1.40727061318012 0.526315789473684 8.2 8 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.34226183158637e-10 4.52284413723406e-09 1.40423333847542 0.525179856115108 8.2 8 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000612677629319076 0.00224123461830603 1.40375243664717 0.525 8.2 8 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 2.58891742069884e-05 0.000136445536653868 1.4026566111697 0.524590163934426 8.2 8 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 2.58891742069884e-05 0.000136445536653868 1.4026566111697 0.524590163934426 8.2 8 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0126069975280369 0.03030364439594 1.40056932454593 0.523809523809524 8.2 8 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.02588517633508e-05 0.00010840774409483 1.40056932454593 0.523809523809524 8.2 8 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000370715286156006 0.00143349959836956 1.39767558627208 0.522727272727273 8.2 8 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.00028861408767461 0.00115041413658535 1.39503347741334 0.521739130434783 8.2 8 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0096451352078166 0.0240789954398649 1.39503347741334 0.521739130434783 8.2 8 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000224812633962568 0.000927270661242707 1.39261154429283 0.520833333333333 8.2 8 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000224812633962568 0.000927270661242707 1.39261154429283 0.520833333333333 8.2 8 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000175200426179648 0.000757781782533857 1.39038336582196 0.52 8.2 8 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00739644819415227 0.0188622684234385 1.39038336582196 0.52 8.2 8 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00739644819415227 0.0188622684234385 1.39038336582196 0.52 8.2 8 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00739644819415227 0.0188622684234385 1.39038336582196 0.52 8.2 8 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00739644819415227 0.0188622684234385 1.39038336582196 0.52 8.2 8 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00739644819415227 0.0188622684234385 1.39038336582196 0.52 8.2 8 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00739644819415227 0.0188622684234385 1.39038336582196 0.52 8.2 8 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 8.05422338241117e-08 7.16322492073193e-07 1.38832658569501 0.519230769230769 8.2 8 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.00568355698972367 0.0154345450312534 1.38642215965153 0.518518518518518 8.2 8 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00568355698972367 0.0154345450312534 1.38642215965153 0.518518518518518 8.2 8 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.52319411078468e-15 4.49203897023948e-13 1.38552188552189 0.518181818181818 8.2 8 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 1.76218415086932e-06 1.13981274849411e-05 1.38522902526284 0.518072289156627 8.2 8 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 8.31411084372022e-05 0.000394998460242628 1.38465376403973 0.517857142857143 8.2 8 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 6.4900853897192e-05 0.00031520107541196 1.38300732674598 0.517241379310345 8.2 8 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 6.4900853897192e-05 0.00031520107541196 1.38300732674598 0.517241379310345 8.2 8 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 6.4900853897192e-05 0.00031520107541196 1.38300732674598 0.517241379310345 8.2 8 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 5.06802558299553e-05 0.000253936633964882 1.38147065193849 0.516666666666667 8.2 8 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 3.09344330024611e-05 0.000158915877842968 1.3786854288499 0.515625 8.2 8 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.41791691772322e-05 0.000128384170668662 1.37741941835509 0.515151515151515 8.2 8 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.00260431649829057 0.00798694477816267 1.37741941835509 0.515151515151515 8.2 8 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 5.07908330560973e-54 7.22753554388264e-51 1.37622787906586 0.514705882352941 8.2 8 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.05161073110411e-09 1.62656746778385e-08 1.37510442773601 0.514285714285714 8.2 8 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 1.47842639320397e-05 8.15426650205136e-05 1.37510442773601 0.514285714285714 8.2 8 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 1.47842639320397e-05 8.15426650205136e-05 1.37510442773601 0.514285714285714 8.2 8 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00201321654393101 0.00645226833786898 1.37510442773601 0.514285714285714 8.2 8 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00201321654393101 0.00645226833786898 1.37510442773601 0.514285714285714 8.2 8 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00201321654393101 0.00645226833786898 1.37510442773601 0.514285714285714 8.2 8 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 1.15650160752877e-05 6.47914089572218e-05 1.37404339036893 0.513888888888889 8.2 8 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00120697926779332 0.00407964726382398 1.37118675130371 0.512820512820513 8.2 8 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00120697926779332 0.00407964726382398 1.37118675130371 0.512820512820513 8.2 8 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 9.48946249641985e-11 1.90190213132471e-09 1.37032975958415 0.5125 8.2 8 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000726301931681993 0.00259680313764693 1.36799794490533 0.511627906976744 8.2 8 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.000726301931681993 0.00259680313764693 1.36799794490533 0.511627906976744 8.2 8 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00026532433137665 0.00106956522251834 1.36312094688428 0.509803921568627 8.2 8 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.000206586141847449 0.000864623764261531 1.36213174445548 0.509433962264151 8.2 8 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.27179562880052e-22 3.23276517978315e-20 1.35835478972734 0.508021390374332 8.2 8 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.63018004483331e-05 0.000184490935849921 1.35686091957367 0.507462686567164 8.2 8 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.83595055951018e-05 0.00014674755077029 1.35628254748519 0.507246376811594 8.2 8 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.73235370955636e-05 9.44497827087624e-05 1.35522087817209 0.506849315068493 8.2 8 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 6.32569043848754e-11 1.30455905709678e-09 1.35245251371322 0.505813953488372 8.2 8 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 3.11098670268624e-06 1.91642167875434e-05 1.35227383059607 0.505747126436782 8.2 8 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 3.11098670268624e-06 1.91642167875434e-05 1.35227383059607 0.505747126436782 8.2 8 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 6.54424653137094e-13 2.45064810898443e-11 1.34963953092608 0.504761904761905 8.2 8 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 6.33889384300049e-08 5.81951350876755e-07 1.34814159581961 0.504201680672269 8.2 8 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 5.63751523421463e-09 7.42794831322908e-08 1.34652511908602 0.503597122302158 8.2 8 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 9.57101379690773e-06 5.42611658685247e-05 1.33690708252112 0.5 8.2 8 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00039404974259126 0.00150330505015379 1.33690708252112 0.5 8.2 8 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00039404974259126 0.00150330505015379 1.33690708252112 0.5 8.2 8 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00855306548034344 0.0215035550857398 1.33690708252112 0.5 8.2 8 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0111531501899933 0.0272696438494167 1.33690708252112 0.5 8.2 8 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0111531501899933 0.0272696438494167 1.33690708252112 0.5 8.2 8 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0585836117862942 0.108547499442574 1.33690708252112 0.5 8.2 8 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.0585836117862942 0.108547499442574 1.33690708252112 0.5 8.2 8 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.0585836117862942 0.108547499442574 1.33690708252112 0.5 8.2 8 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0585836117862942 0.108547499442574 1.33690708252112 0.5 8.2 8 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0585836117862942 0.108547499442574 1.33690708252112 0.5 8.2 8 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.94421073818785e-09 2.73921968360525e-08 1.33690708252112 0.5 8.2 8 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 7.31534260278069e-08 6.5470015872685e-07 1.33690708252112 0.5 8.2 8 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000185965493965307 0.00079230208955878 1.33690708252112 0.5 8.2 8 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000185965493965307 0.00079230208955878 1.33690708252112 0.5 8.2 8 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00030662445309743 0.00120866093284665 1.33690708252112 0.5 8.2 8 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00657229091637917 0.0172552951549955 1.33690708252112 0.5 8.2 8 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00657229091637917 0.0172552951549955 1.33690708252112 0.5 8.2 8 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0251149235248967 0.0527117052742301 1.33690708252112 0.5 8.2 8 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0251149235248967 0.0527117052742301 1.33690708252112 0.5 8.2 8 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0251149235248967 0.0527117052742301 1.33690708252112 0.5 8.2 8 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.106726880888936 0.181883055694558 1.33690708252112 0.5 8.2 8 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.106726880888936 0.181883055694558 1.33690708252112 0.5 8.2 8 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.106726880888936 0.181883055694558 1.33690708252112 0.5 8.2 8 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00301124320723721 0.00904008245548217 1.33690708252112 0.5 8.2 8 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00390040717202539 0.0112126856682669 1.33690708252112 0.5 8.2 8 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00390040717202539 0.0112126856682669 1.33690708252112 0.5 8.2 8 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0191037014863771 0.0427430302124445 1.33690708252112 0.5 8.2 8 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0191037014863771 0.0427430302124445 1.33690708252112 0.5 8.2 8 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0191037014863771 0.0427430302124445 1.33690708252112 0.5 8.2 8 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.033142578967585 0.0674705148367289 1.33690708252112 0.5 8.2 8 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.033142578967585 0.0674705148367289 1.33690708252112 0.5 8.2 8 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.033142578967585 0.0674705148367289 1.33690708252112 0.5 8.2 8 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.033142578967585 0.0674705148367289 1.33690708252112 0.5 8.2 8 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.0439377355864159 0.0842633392715226 1.33690708252112 0.5 8.2 8 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0439377355864159 0.0842633392715226 1.33690708252112 0.5 8.2 8 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0439377355864159 0.0842633392715226 1.33690708252112 0.5 8.2 8 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.0439377355864159 0.0842633392715226 1.33690708252112 0.5 8.2 8 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0439377355864159 0.0842633392715226 1.33690708252112 0.5 8.2 8 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0439377355864159 0.0842633392715226 1.33690708252112 0.5 8.2 8 2 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.0786869554263969 0.137895982231235 1.33690708252112 0.5 8.2 8 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0786869554263969 0.137895982231235 1.33690708252112 0.5 8.2 8 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0786869554263969 0.137895982231235 1.33690708252112 0.5 8.2 8 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0786869554263969 0.137895982231235 1.33690708252112 0.5 8.2 8 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 1.2082848421874e-08 1.521583478259e-07 1.32742547200678 0.49645390070922 8.2 8 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 6.57263709386702e-08 5.9572373150145e-07 1.32638025509969 0.496062992125984 8.2 8 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.06712610234999e-07 9.37358298545704e-07 1.32603791924859 0.495934959349593 8.2 8 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.22917826528644e-08 2.34971901592785e-07 1.31780840991367 0.492857142857143 8.2 8 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 5.86415514157543e-08 5.45404755977898e-07 1.31665091460413 0.492424242424242 8.2 8 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000271185358109163 0.00108774154457878 1.31424764044449 0.491525423728814 8.2 8 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000447110368782765 0.00168763409755404 1.31259968102073 0.490909090909091 8.2 8 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000447110368782765 0.00168763409755404 1.31259968102073 0.490909090909091 8.2 8 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000447110368782765 0.00168763409755404 1.31259968102073 0.490909090909091 8.2 8 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000950608794560802 0.00328329202587384 1.30962326451048 0.489795918367347 8.2 8 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.57287351236685e-09 2.30742165783302e-08 1.30545044528533 0.488235294117647 8.2 8 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 8.80233826507678e-05 0.000416137121302467 1.29977077467331 0.486111111111111 8.2 8 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.96656687671754e-06 1.26625550478238e-05 1.29942370637567 0.485981308411215 8.2 8 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0056827538763368 0.0154345450312534 1.29870973730623 0.485714285714286 8.2 8 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.85299276139526e-09 3.86648447568138e-08 1.2973536185412 0.485207100591716 8.2 8 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 5.86886059923112e-09 7.66182443367513e-08 1.29589766281188 0.484662576687117 8.2 8 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000236804970097766 0.000971105107922539 1.29512873619233 0.484375 8.2 8 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00957146345092781 0.0239370694036385 1.29378104760108 0.483870967741935 8.2 8 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 7.53990272575424e-10 1.20553725603913e-08 1.29331228635195 0.483695652173913 8.2 8 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0124524907073258 0.0300337191127537 1.29080683829625 0.482758620689655 8.2 8 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000641120047957138 0.0023214092321705 1.28916040100251 0.482142857142857 8.2 8 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0162320581616723 0.0374363351119282 1.28739200539071 0.481481481481481 8.2 8 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0162320581616723 0.0374363351119282 1.28739200539071 0.481481481481481 8.2 8 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0162320581616723 0.0374363351119282 1.28739200539071 0.481481481481481 8.2 8 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 5.98631930580244e-05 0.000294758905610964 1.28613845913424 0.481012658227848 8.2 8 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.00225333747518661 0.00698583709627571 1.2787806876289 0.478260869565217 8.2 8 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00374374716180069 0.0108279516488666 1.2732448404963 0.476190476190476 8.2 8 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00374374716180069 0.0108279516488666 1.2732448404963 0.476190476190476 8.2 8 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0364857653402238 0.0726143273834105 1.2732448404963 0.476190476190476 8.2 8 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.0364857653402238 0.0726143273834105 1.2732448404963 0.476190476190476 8.2 8 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.0364857653402238 0.0726143273834105 1.2732448404963 0.476190476190476 8.2 8 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.63698916774744e-07 1.38656880101464e-06 1.27146407848162 0.475524475524476 8.2 8 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.29500088020733e-06 8.61115071278051e-06 1.27115755387254 0.475409836065574 8.2 8 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000550546099789855 0.00202960388601286 1.27115755387254 0.475409836065574 8.2 8 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00483183076982534 0.0135883304060503 1.27006172839506 0.475 8.2 8 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 4.27231234863449e-08 4.19275894628061e-07 1.26921558467195 0.474683544303797 8.2 8 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 5.42691371539612e-08 5.11423722980708e-07 1.26834774495593 0.474358974358974 8.2 8 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00624225327496599 0.0164800118929065 1.26654355186211 0.473684210526316 8.2 8 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00116071960248789 0.00394201430630135 1.26398487801997 0.472727272727273 8.2 8 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00116071960248789 0.00394201430630135 1.26398487801997 0.472727272727273 8.2 8 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00116071960248789 0.00394201430630135 1.26398487801997 0.472727272727273 8.2 8 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.11586674655362e-06 7.54266709482934e-06 1.26321929057113 0.47244094488189 8.2 8 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000224423840791389 0.000927270661242707 1.2626344668255 0.472222222222222 8.2 8 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00148968974046876 0.00494092374011495 1.26123309671804 0.471698113207547 8.2 8 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.00148968974046876 0.00494092374011495 1.26123309671804 0.471698113207547 8.2 8 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0636803951140458 0.116358979602061 1.25826548943164 0.470588235294118 8.2 8 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0636803951140458 0.116358979602061 1.25826548943164 0.470588235294118 8.2 8 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0636803951140458 0.116358979602061 1.25826548943164 0.470588235294118 8.2 8 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.925525680663e-11 4.80705797119903e-10 1.25637051128491 0.469879518072289 8.2 8 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.000117349434310069 0.000531809697526204 1.25438195397043 0.469135802469136 8.2 8 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000117349434310069 0.000531809697526204 1.25438195397043 0.469135802469136 8.2 8 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0135529364197362 0.0321430475421411 1.25335038986355 0.46875 8.2 8 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0847480402179718 0.147971118073833 1.24777994368638 0.466666666666667 8.2 8 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0847480402179718 0.147971118073833 1.24777994368638 0.466666666666667 8.2 8 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.000311019867537382 0.00121923215290825 1.24533810426625 0.465753424657534 8.2 8 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.22079660734179e-05 0.000164863078138394 1.24237829890851 0.464646464646465 8.2 8 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0228871851521573 0.0483211639043322 1.2414137194839 0.464285714285714 8.2 8 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0228871851521573 0.0483211639043322 1.2414137194839 0.464285714285714 8.2 8 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 4.34592849796701e-06 2.59842699689372e-05 1.23908461306835 0.463414634146341 8.2 8 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00673733196789422 0.0175590171983763 1.23908461306835 0.463414634146341 8.2 8 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00206409722738539 0.00660047270689755 1.23787692826029 0.462962962962963 8.2 8 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.0298220747642694 0.0612868611291613 1.23406807617334 0.461538461538462 8.2 8 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.113524212945387 0.192086747944454 1.23406807617334 0.461538461538462 8.2 8 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.113524212945387 0.192086747944454 1.23406807617334 0.461538461538462 8.2 8 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.113524212945387 0.192086747944454 1.23406807617334 0.461538461538462 8.2 8 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.113524212945387 0.192086747944454 1.23406807617334 0.461538461538462 8.2 8 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.113524212945387 0.192086747944454 1.23406807617334 0.461538461538462 8.2 8 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000107173145761148 0.000491959311026175 1.23175708726665 0.460674157303371 8.2 8 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000334390932079324 0.00130366656533939 1.23136178653261 0.460526315789474 8.2 8 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000334390932079324 0.00130366656533939 1.23136178653261 0.460526315789474 8.2 8 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.90728598093735e-08 2.9340907453006e-07 1.22966854649001 0.459893048128342 8.2 8 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000173384941422166 0.00075221576720653 1.22680885219585 0.458823529411765 8.2 8 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000173384941422166 0.00075221576720653 1.22680885219585 0.458823529411765 8.2 8 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000173384941422166 0.00075221576720653 1.22680885219585 0.458823529411765 8.2 8 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000173384941422166 0.00075221576720653 1.22680885219585 0.458823529411765 8.2 8 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000173384941422166 0.00075221576720653 1.22680885219585 0.458823529411765 8.2 8 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0389405954277485 0.0757129981936425 1.22549815897769 0.458333333333333 8.2 8 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0389405954277485 0.0757129981936425 1.22549815897769 0.458333333333333 8.2 8 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0389405954277485 0.0757129981936425 1.22549815897769 0.458333333333333 8.2 8 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.0389405954277485 0.0757129981936425 1.22549815897769 0.458333333333333 8.2 8 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 2.92068083463232e-05 0.000150584377814558 1.22445695408476 0.457943925233645 8.2 8 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0144704348786489 0.0341483065212561 1.22231504687645 0.457142857142857 8.2 8 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0144704348786489 0.0341483065212561 1.22231504687645 0.457142857142857 8.2 8 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.81462490222146e-13 2.2362733069895e-11 1.22208070733525 0.457055214723926 8.2 8 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00281691191479996 0.00854683508477685 1.2153700750192 0.454545454545455 8.2 8 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0187057686874316 0.04224784478946 1.2153700750192 0.454545454545455 8.2 8 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000184706622560902 0.000791679288867963 1.2153700750192 0.454545454545455 8.2 8 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.15335925234271 0.246186513616827 1.2153700750192 0.454545454545455 8.2 8 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.00921029332944968 0.0231150747933102 1.20958259847149 0.452380952380952 8.2 8 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0242074789966789 0.0510329520181839 1.20752897776101 0.451612903225806 8.2 8 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.34294237033989e-19 3.17133799532911e-17 1.20672137411082 0.451310861423221 8.2 8 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.57098957322648e-27 7.31703632540258e-25 1.20509934199087 0.450704225352113 8.2 8 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.000934208884544858 0.00323449937398378 1.20509934199087 0.450704225352113 8.2 8 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.066905386495829 0.120667129256736 1.20321637426901 0.45 8.2 8 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.066905386495829 0.120667129256736 1.20321637426901 0.45 8.2 8 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.066905386495829 0.120667129256736 1.20321637426901 0.45 8.2 8 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.066905386495829 0.120667129256736 1.20321637426901 0.45 8.2 8 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0058944698647967 0.0158272641759562 1.20048799246794 0.448979591836735 8.2 8 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0313653743885828 0.064312576015783 1.19860634984652 0.448275862068966 8.2 8 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 2.54449555654253e-10 4.8277562359467e-09 1.19694208110194 0.447653429602888 8.2 8 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0152231289578386 0.0358058057967014 1.19618002120311 0.447368421052632 8.2 8 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0152231289578386 0.0358058057967014 1.19618002120311 0.447368421052632 8.2 8 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 9.84011652875884e-22 1.07711429387876e-19 1.19344426962227 0.446345256609642 8.2 8 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000260793090982336 0.00105728936885431 1.19159109529056 0.445652173913043 8.2 8 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.74992693227714e-06 1.70879739066828e-05 1.190278563793 0.445161290322581 8.2 8 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.74992693227714e-06 1.70879739066828e-05 1.190278563793 0.445161290322581 8.2 8 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.040694088046347 0.0790009376397705 1.18836185112988 0.444444444444444 8.2 8 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0195883404647221 0.0437585690444263 1.18836185112988 0.444444444444444 8.2 8 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0881106480312143 0.15271796851208 1.18836185112988 0.444444444444444 8.2 8 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0881106480312143 0.15271796851208 1.18836185112988 0.444444444444444 8.2 8 2 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.0881106480312143 0.15271796851208 1.18836185112988 0.444444444444444 8.2 8 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0123609615702444 0.0299873153183773 1.18145277060006 0.441860465116279 8.2 8 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00786054823052516 0.0198677799858567 1.17647823261858 0.44 8.2 8 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0528751969485162 0.0987420016505755 1.17647823261858 0.44 8.2 8 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 5.96754318063671e-07 4.2038682901218e-06 1.16979369720598 0.4375 8.2 8 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0100253349243586 0.0248105245171518 1.16979369720598 0.4375 8.2 8 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.116489388264738 0.195939006502035 1.16979369720598 0.4375 8.2 8 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.116489388264738 0.195939006502035 1.16979369720598 0.4375 8.2 8 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.116489388264738 0.195939006502035 1.16979369720598 0.4375 8.2 8 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.116489388264738 0.195939006502035 1.16979369720598 0.4375 8.2 8 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.116489388264738 0.195939006502035 1.16979369720598 0.4375 8.2 8 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00639311786394497 0.0168470494822105 1.16675527201843 0.436363636363636 8.2 8 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0202752781126966 0.044662106430909 1.16550873860815 0.435897435897436 8.2 8 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 6.57798486917057e-05 0.000318383417307133 1.16440294284097 0.435483870967742 8.2 8 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.0127860693844824 0.0305791205615436 1.16252789784445 0.434782608695652 8.2 8 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0127860693844824 0.0305791205615436 1.16252789784445 0.434782608695652 8.2 8 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0127860693844824 0.0305791205615436 1.16252789784445 0.434782608695652 8.2 8 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0688144836620483 0.123018857099365 1.16252789784445 0.434782608695652 8.2 8 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0688144836620483 0.123018857099365 1.16252789784445 0.434782608695652 8.2 8 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00110520396291178 0.00378054144044103 1.15972662580145 0.433734939759036 8.2 8 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.000467499577752087 0.00173695012830606 1.1577339683688 0.43298969072165 8.2 8 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.000134256074042622 0.000598891515243421 1.14907716183633 0.429752066115702 8.2 8 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0207935117902361 0.0457328705989272 1.14592035644667 0.428571428571429 8.2 8 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.61034173755151e-13 7.39198804043808e-12 1.13434540335125 0.424242424242424 8.2 8 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0426543493723451 0.082581141709996 1.13434540335125 0.424242424242424 8.2 8 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0133829916734906 0.0318929700209466 1.13122906982556 0.423076923076923 8.2 8 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 2.7384244823107e-05 0.000142739122283081 1.12931281504889 0.422360248447205 8.2 8 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0211668122795955 0.0464820584473216 1.12894375857339 0.422222222222222 8.2 8 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00357617182765343 0.010557868279566 1.1258164905441 0.421052631578947 8.2 8 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.117209535211072 0.196917554433714 1.1258164905441 0.421052631578947 8.2 8 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 3.47317602902665e-05 0.000177144426139962 1.12234174828933 0.419753086419753 8.2 8 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.054666948094056 0.101954216432296 1.12127690792094 0.419354838709677 8.2 8 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.19886979169149e-37 1.042997237859e-34 1.12027462434629 0.418979987088444 8.2 8 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.090152975257977 0.1556889366409 1.11408923543426 0.416666666666667 8.2 8 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.090152975257977 0.1556889366409 1.11408923543426 0.416666666666667 8.2 8 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.206696607282934 0.316268034584533 1.11408923543426 0.416666666666667 8.2 8 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.206696607282934 0.316268034584533 1.11408923543426 0.416666666666667 8.2 8 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.206696607282934 0.316268034584533 1.11408923543426 0.416666666666667 8.2 8 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.206696607282934 0.316268034584533 1.11408923543426 0.416666666666667 8.2 8 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.206696607282934 0.316268034584533 1.11408923543426 0.416666666666667 8.2 8 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.206696607282934 0.316268034584533 1.11408923543426 0.416666666666667 8.2 8 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.206696607282934 0.316268034584533 1.11408923543426 0.416666666666667 8.2 8 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 8.52477343029501e-06 4.88638688647043e-05 1.11295818037291 0.416243654822335 8.2 8 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 0.000547121962231099 0.00202221961624637 1.10488188638109 0.413223140495868 8.2 8 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 0.000547121962231099 0.00202221961624637 1.10488188638109 0.413223140495868 8.2 8 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.000103803442990926 0.000479585387584698 1.10402649395292 0.412903225806452 8.2 8 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.153455683470222 0.246186513616827 1.10098230325268 0.411764705882353 8.2 8 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.153455683470222 0.246186513616827 1.10098230325268 0.411764705882353 8.2 8 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.94917391068742e-13 1.27171953785097e-11 1.10043139892281 0.411558669001751 8.2 8 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0432003217358976 0.0835245350953563 1.09694940104297 0.41025641025641 8.2 8 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0271348484830514 0.0568672892362035 1.0913527204254 0.408163265306122 8.2 8 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00016121876920857 0.000710261017287293 1.08996246218282 0.407643312101911 8.2 8 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0057498104725035 0.0155847243854714 1.08933169686906 0.407407407407407 8.2 8 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0698376762220756 0.12469135917693 1.08623700454841 0.40625 8.2 8 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.11044175719086e-10 4.17105363955915e-09 1.07604716398041 0.402439024390244 8.2 8 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.05426157731395e-19 2.08801016036982e-17 1.07327275293487 0.401401401401401 8.2 8 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0137510151630205 0.0325585600282499 1.06952566601689 0.4 8.2 8 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0888399575189807 0.153794719646605 1.06952566601689 0.4 8.2 8 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.201384079545863 0.31422099253702 1.06952566601689 0.4 8.2 8 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.201384079545863 0.31422099253702 1.06952566601689 0.4 8.2 8 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.12705028875001e-05 6.33910103119076e-05 1.05904012027163 0.396078431372549 8.2 8 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.000130889494354299 0.00058755757244848 1.05838477366255 0.395833333333333 8.2 8 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0424397203731833 0.0822775505327518 1.05838477366255 0.395833333333333 8.2 8 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0875068386744004 0.15222766678933 1.0533207316833 0.393939393939394 8.2 8 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0875068386744004 0.15222766678933 1.0533207316833 0.393939393939394 8.2 8 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.02645537099261e-05 0.00010840774409483 1.05042699340945 0.392857142857143 8.2 8 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.02645537099261e-05 0.00010840774409483 1.05042699340945 0.392857142857143 8.2 8 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.02645537099261e-05 0.00010840774409483 1.05042699340945 0.392857142857143 8.2 8 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.147231416300918 0.239440349024236 1.04627510806001 0.391304347826087 8.2 8 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 3.54350799026281e-08 3.52616214695383e-07 1.04314723030796 0.390134529147982 8.2 8 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.000812894767875147 0.00283516974187827 1.04261935995358 0.389937106918239 8.2 8 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.000812894767875147 0.00283516974187827 1.04261935995358 0.389937106918239 8.2 8 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0328419215513449 0.0672432436943363 1.04233433552494 0.389830508474576 8.2 8 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0858965160444727 0.149792576386378 1.03981661973865 0.388888888888889 8.2 8 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.143269832202192 0.236511567544918 1.02839006347778 0.384615384615385 8.2 8 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.264929353743901 0.399358549128784 1.02839006347778 0.384615384615385 8.2 8 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.264929353743901 0.399358549128784 1.02839006347778 0.384615384615385 8.2 8 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.264929353743901 0.399358549128784 1.02839006347778 0.384615384615385 8.2 8 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.264929353743901 0.399358549128784 1.02839006347778 0.384615384615385 8.2 8 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0125515183349205 0.0302213377167375 1.02401393554809 0.382978723404255 8.2 8 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0501675733500142 0.0949315558613537 1.02091086301613 0.381818181818182 8.2 8 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.00394443006427416 0.0113163789948833 1.01487836921311 0.37956204379562 8.2 8 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.00387570748020074 0.0111868798059344 1.01222964819456 0.378571428571429 8.2 8 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.104873981674708 0.179369802792199 1.01171346785382 0.378378378378378 8.2 8 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0801402101044882 0.140270011043895 1.0101075734604 0.377777777777778 8.2 8 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.181478480926682 0.285117864229338 1.00268031189084 0.375 8.2 8 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.00541583095495357 0.0149066294949689 0.997972892586186 0.373239436619718 8.2 8 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.00665059906298955 0.0174287338243722 0.995361477497475 0.372262773722628 8.2 8 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.174735646425975 0.278130676581836 0.990301542608235 0.37037037037037 8.2 8 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.174735646425975 0.278130676581836 0.990301542608235 0.37037037037037 8.2 8 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.174735646425975 0.278130676581836 0.990301542608235 0.37037037037037 8.2 8 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.240439343540998 0.363984240275362 0.985089429226087 0.368421052631579 8.2 8 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.240439343540998 0.363984240275362 0.985089429226087 0.368421052631579 8.2 8 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.00463531980899844 0.0131395619286948 0.984226073021682 0.368098159509202 8.2 8 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.00934944669729496 0.0234229976236808 0.983019913618469 0.367647058823529 8.2 8 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.168156082409162 0.268636737178867 0.980398527182153 0.366666666666667 8.2 8 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.168156082409162 0.268636737178867 0.980398527182153 0.366666666666667 8.2 8 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.16178388757435 0.259255036056645 0.972296060015358 0.363636363636364 8.2 8 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.109916045215753 0.187093938208154 0.962573099415205 0.36 8.2 8 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.218869910999282 0.333103618558265 0.962573099415205 0.36 8.2 8 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.326151403704565 0.460887236813899 0.954933630372227 0.357142857142857 8.2 8 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.326151403704565 0.460887236813899 0.954933630372227 0.357142857142857 8.2 8 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.326151403704565 0.460887236813899 0.954933630372227 0.357142857142857 8.2 8 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.326151403704565 0.460887236813899 0.954933630372227 0.357142857142857 8.2 8 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.326151403704565 0.460887236813899 0.954933630372227 0.357142857142857 8.2 8 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.326151403704565 0.460887236813899 0.954933630372227 0.357142857142857 8.2 8 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.326151403704565 0.460887236813899 0.954933630372227 0.357142857142857 8.2 8 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.326151403704565 0.460887236813899 0.954933630372227 0.357142857142857 8.2 8 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.00295524834916764 0.00889073657688277 0.952474573813328 0.356223175965665 8.2 8 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.19990932677221 0.312949364132953 0.948772768240793 0.354838709677419 8.2 8 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0495109195016395 0.09482373950314 0.948772768240793 0.354838709677419 8.2 8 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0356211194608882 0.0711922092596122 0.947988658514974 0.354545454545455 8.2 8 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0608469836532382 0.112594613444159 0.941911808139878 0.352272727272727 8.2 8 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.288735956179845 0.424580863798698 0.935834957764782 0.35 8.2 8 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.168204731431041 0.268636737178867 0.932725871526361 0.348837209302326 8.2 8 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.234027804237745 0.355033651844682 0.919123619233268 0.34375 8.2 8 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.234027804237745 0.355033651844682 0.919123619233268 0.34375 8.2 8 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0981840626412117 0.168129868999331 0.900653192435279 0.336842105263158 8.2 8 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.388535065783917 0.539400388888306 0.891271388347412 0.333333333333333 8.2 8 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.388535065783917 0.539400388888306 0.891271388347412 0.333333333333333 8.2 8 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.388535065783917 0.539400388888306 0.891271388347412 0.333333333333333 8.2 8 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.270149762569443 0.404739674411437 0.891271388347412 0.333333333333333 8.2 8 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.338954030325703 0.478029321262116 0.891271388347412 0.333333333333333 8.2 8 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.361851615515088 0.50680595362005 0.891271388347412 0.333333333333333 8.2 8 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.361851615515088 0.50680595362005 0.891271388347412 0.333333333333333 8.2 8 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.143901662328978 0.237004705433027 0.880785842602148 0.329411764705882 8.2 8 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.143901662328978 0.237004705433027 0.880785842602148 0.329411764705882 8.2 8 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.200308182980838 0.313229169650255 0.876660381981061 0.327868852459016 8.2 8 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.307872825442578 0.439421294488254 0.865057523984253 0.323529411764706 8.2 8 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.228068275972178 0.346732005030351 0.852520458419263 0.318840579710145 8.2 8 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.390125126590708 0.540553120874953 0.850759052513438 0.318181818181818 8.2 8 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.390125126590708 0.540553120874953 0.850759052513438 0.318181818181818 8.2 8 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.28540215691836 0.420421603824872 0.841756311217 0.314814814814815 8.2 8 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.31409245818678 0.447400968968757 0.835566926575698 0.3125 8.2 8 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.299678508903266 0.428155138724245 0.80214424951267 0.3 8.2 8 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.309928010099757 0.441911381134223 0.797002299195282 0.298076923076923 8.2 8 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.510535275483793 0.669577600934044 0.786415930894775 0.294117647058824 8.2 8 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.434447816763148 0.591031781313537 0.779862464803985 0.291666666666667 8.2 8 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.507432089800123 0.666121645558648 0.763946904297782 0.285714285714286 8.2 8 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.526952911629612 0.682927134106501 0.763946904297781 0.285714285714286 8.2 8 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.492639566123578 0.647940203261171 0.755643133598893 0.282608695652174 8.2 8 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.505542384935575 0.664253752320705 0.754152713217041 0.282051282051282 8.2 8 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.492671328129717 0.647940203261171 0.744606476340876 0.278481012658228 8.2 8 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.492592211997046 0.647940203261171 0.742726156956176 0.277777777777778 8.2 8 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.330790100023666 0.466978484458013 0.739537869062901 0.276585365853659 8.2 8 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.552608378295659 0.711639567705631 0.737603907597858 0.275862068965517 8.2 8 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.587561647542934 0.754603090662089 0.719873044434448 0.269230769230769 8.2 8 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.587561647542934 0.754603090662089 0.719873044434448 0.269230769230769 8.2 8 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.595949662161601 0.763309063236686 0.713017110677929 0.266666666666667 8.2 8 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.593125050817633 0.761061268993229 0.71076072741629 0.265822784810127 8.2 8 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.59418251080482 0.761731272860594 0.710231887589344 0.265625 8.2 8 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.62123317348253 0.771391628155008 0.703635306590062 0.263157894736842 8.2 8 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.631900671802238 0.783953492567205 0.693211079825765 0.259259259259259 8.2 8 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.705793019521764 0.865067585512032 0.675205597232888 0.252525252525253 8.2 8 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.673390199136276 0.831800567162257 0.668453541260559 0.25 8.2 8 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.670564582795779 0.830227605214408 0.668453541260559 0.25 8.2 8 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.670564582795779 0.830227605214408 0.668453541260559 0.25 8.2 8 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.671533361631612 0.830227605214408 0.668453541260559 0.25 8.2 8 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.722803586695392 0.867974264867124 0.657495286485796 0.245901639344262 8.2 8 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.720692702914002 0.866170368451541 0.656726286150724 0.245614035087719 8.2 8 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.713600539734336 0.86539441674738 0.652149796351765 0.24390243902439 8.2 8 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.712464947393367 0.86539441674738 0.650387229334598 0.243243243243243 8.2 8 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.711802415760646 0.86539441674738 0.648197373343572 0.242424242424242 8.2 8 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.712849587620113 0.86539441674738 0.641715399610136 0.24 8.2 8 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.712849587620113 0.86539441674738 0.641715399610136 0.24 8.2 8 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.770489461137175 0.916727845483445 0.636622420248151 0.238095238095238 8.2 8 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.769875246379282 0.916727845483445 0.631992439009983 0.236363636363636 8.2 8 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.920852774358352 1 0.62913274471582 0.235294117647059 8.2 8 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.747085900856886 0.89370424991092 0.623889971843188 0.233333333333333 8.2 8 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.779166976169228 0.923962172574009 0.603764488880505 0.225806451612903 8.2 8 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.966392560960667 1 0.578121981630754 0.216216216216216 8.2 8 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.861185443935893 0.991478063689949 0.56889663086005 0.212765957446809 8.2 8 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.850907964931077 0.981803345440062 0.534762833008447 0.2 8.2 8 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.864918146916326 0.994166819920784 0.534762833008447 0.2 8.2 8 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.874829868571033 1 0.514195031738891 0.192307692307692 8.2 8 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.903355520625226 1 0.501340155945419 0.1875 8.2 8 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.945020425199928 1 0.491108724191431 0.183673469387755 8.2 8 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.998345174971934 1 0.488761729093742 0.182795698924731 8.2 8 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.931966357476698 1 0.471849558536865 0.176470588235294 8.2 8 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.999187741681332 1 0.456504857446235 0.170731707317073 8.2 8 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.970006303679403 1 0.445635694173706 0.166666666666667 8.2 8 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.951077628663235 1 0.43126034920036 0.161290322580645 8.2 8 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.951077628663235 1 0.43126034920036 0.161290322580645 8.2 8 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.993448857917404 1 0.41425289880936 0.154929577464789 8.2 8 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.978369694057565 1 0.381973452148891 0.142857142857143 8.2 8 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99999999991574 1 0.372128775547115 0.139175257731959 8.2 8 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999999735469125 1 0.357330003623156 0.133640552995392 8.2 8 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.995600376233659 1 0.35314526708105 0.132075471698113 8.2 8 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.988622698108931 1 0.351817653295031 0.131578947368421 8.2 8 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.994877828884355 1 0.34133797851603 0.127659574468085 8.2 8 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.334507397641724 0.125104953820319 8.2 8 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999962565874529 1 0.321848001347676 0.12037037037037 8.2 8 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999999999766 1 0.267381416504224 0.1 8.2 8 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.258678223923616 0.096745027124774 8.2 8 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999996374009388 1 0.237672370225976 0.0888888888888889 8.2 8 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999999999821 1 0.16711338531514 0.0625 8.2 8 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.021563017460018 0.00806451612903226 8.2 8 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 1.96801325153563e-10 5.18607936469481e-09 3.03953322219576 1 8.1 8 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%REACT_198242.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 0.000928869860963394 0.00367161614486364 3.03953322219576 1 8.1 8 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000356457765308094 0.00159009216311416 2.65959156942129 0.875 8.1 8 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 2.85533176079343e-06 2.25729838644947e-05 2.60531419045351 0.857142857142857 8.1 8 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00126768762642623 0.00479765822448013 2.60531419045351 0.857142857142857 8.1 8 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.00126768762642623 0.00479765822448013 2.60531419045351 0.857142857142857 8.1 8 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 3.41630320658446e-05 0.000212288186155881 2.5329443518298 0.833333333333333 8.1 8 1 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.00442401005833826 0.0142752070589917 2.5329443518298 0.833333333333333 8.1 8 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00442401005833826 0.0142752070589917 2.5329443518298 0.833333333333333 8.1 8 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.00442401005833826 0.0142752070589917 2.5329443518298 0.833333333333333 8.1 8 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.000115772549909905 0.00061392208936708 2.48689081816017 0.818181818181818 8.1 8 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 3.33870935722535e-06 2.56809914342252e-05 2.46962074303406 0.8125 8.1 8 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 1.00705545443362e-07 1.07130929137218e-06 2.46057451320609 0.80952380952381 8.1 8 1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.000385667578708373 0.00167830264373705 2.43162657775661 0.8 8.1 8 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000385667578708373 0.00167830264373705 2.43162657775661 0.8 8.1 8 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.000385667578708373 0.00167830264373705 2.43162657775661 0.8 8.1 8 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.000385667578708373 0.00167830264373705 2.43162657775661 0.8 8.1 8 1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%REACT_205038.1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 0.000385667578708373 0.00167830264373705 2.43162657775661 0.8 8.1 8 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 3.32228817851506e-08 4.87383100827518e-07 2.40629713423831 0.791666666666667 8.1 8 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.00125833782127028 0.0047877398921594 2.36408139504115 0.777777777777778 8.1 8 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.00125833782127028 0.0047877398921594 2.36408139504115 0.777777777777778 8.1 8 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00125833782127028 0.0047877398921594 2.36408139504115 0.777777777777778 8.1 8 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.00125833782127028 0.0047877398921594 2.36408139504115 0.777777777777778 8.1 8 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00125833782127028 0.0047877398921594 2.36408139504115 0.777777777777778 8.1 8 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 3.41537323240367e-09 6.07509513713803e-08 2.33030880368342 0.766666666666667 8.1 8 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.06056285899059e-07 1.08574168945583e-06 2.31004524886878 0.76 8.1 8 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 3.41010741340144e-05 0.000212288186155881 2.27964991664682 0.75 8.1 8 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 3.41010741340144e-05 0.000212288186155881 2.27964991664682 0.75 8.1 8 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000360601103442086 0.00159358810620524 2.27964991664682 0.75 8.1 8 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.000360601103442086 0.00159358810620524 2.27964991664682 0.75 8.1 8 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00400137720978064 0.013029656223153 2.27964991664682 0.75 8.1 8 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 3.01880485621228e-07 2.88305993985911e-06 2.22119735468152 0.730769230769231 8.1 8 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.00110538765550429 0.00429704512624387 2.21056961614237 0.727272727272727 8.1 8 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 9.28826298264377e-09 1.4366519809024e-07 2.21056961614237 0.727272727272727 8.1 8 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 3.04172225127655e-05 0.00019323083765922 2.19521843825249 0.722222222222222 8.1 8 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.000312445384878975 0.00142047853892263 2.17109515871126 0.714285714285714 8.1 8 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.000312445384878975 0.00142047853892263 2.17109515871126 0.714285714285714 8.1 8 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.000312445384878975 0.00142047853892263 2.17109515871126 0.714285714285714 8.1 8 1 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0123148161381183 0.0338955190803528 2.17109515871126 0.714285714285714 8.1 8 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0123148161381183 0.0338955190803528 2.17109515871126 0.714285714285714 8.1 8 1 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0123148161381183 0.0338955190803528 2.17109515871126 0.714285714285714 8.1 8 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.0123148161381183 0.0338955190803528 2.17109515871126 0.714285714285714 8.1 8 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 8.04001127676237e-08 9.66276928605293e-07 2.15708809317119 0.709677419354839 8.1 8 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 7.25201648104485e-09 1.17268402869623e-07 2.13588821019162 0.702702702702703 8.1 8 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 7.25201648104485e-09 1.17268402869623e-07 2.13588821019162 0.702702702702703 8.1 8 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 2.60167610350964e-05 0.000168281140695192 2.12767325553703 0.7 8.1 8 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 2.60167610350964e-05 0.000168281140695192 2.12767325553703 0.7 8.1 8 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.00329456838724808 0.0110309901530683 2.12767325553703 0.7 8.1 8 1 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.00329456838724808 0.0110309901530683 2.12767325553703 0.7 8.1 8 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00329456838724808 0.0110309901530683 2.12767325553703 0.7 8.1 8 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 6.93321267112497e-08 9.55243944840627e-07 2.11846254880311 0.696969696969697 8.1 8 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 7.60991923028169e-06 5.38751993268201e-05 2.1144578937014 0.695652173913043 8.1 8 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 2.23995001978682e-06 1.81105049895264e-05 2.10429223075091 0.692307692307692 8.1 8 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 2.23995001978682e-06 1.81105049895264e-05 2.10429223075091 0.692307692307692 8.1 8 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000913392962235599 0.00363060945603703 2.10429223075091 0.692307692307692 8.1 8 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000258767936802395 0.0012356603156705 2.08967909025959 0.6875 8.1 8 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 7.43834336247412e-05 0.000426804943741963 2.07968062571289 0.684210526315789 8.1 8 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 2.16059357788931e-05 0.000141033241345711 2.07240901513347 0.681818181818182 8.1 8 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.6385392847326e-07 1.61919541817673e-06 2.05615482677949 0.676470588235294 8.1 8 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.34482339548579e-07 1.34766457167344e-06 2.02635548146384 0.666666666666667 8.1 8 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 4.51786566004027e-07 4.20191034917471e-06 2.02635548146384 0.666666666666667 8.1 8 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 5.15786012497524e-06 3.76391536299475e-05 2.02635548146384 0.666666666666667 8.1 8 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 1.75600606520732e-05 0.000116223099106513 2.02635548146384 0.666666666666667 8.1 8 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 1.75600606520732e-05 0.000116223099106513 2.02635548146384 0.666666666666667 8.1 8 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 1.75600606520732e-05 0.000116223099106513 2.02635548146384 0.666666666666667 8.1 8 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 6.01934742475424e-05 0.000349613525935726 2.02635548146384 0.666666666666667 8.1 8 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000208179964459181 0.00101452085419663 2.02635548146384 0.666666666666667 8.1 8 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000208179964459181 0.00101452085419663 2.02635548146384 0.666666666666667 8.1 8 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000728717217201158 0.00299700751467412 2.02635548146384 0.666666666666667 8.1 8 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00259496075962869 0.00902843315636096 2.02635548146384 0.666666666666667 8.1 8 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00259496075962869 0.00902843315636096 2.02635548146384 0.666666666666667 8.1 8 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00259496075962869 0.00902843315636096 2.02635548146384 0.666666666666667 8.1 8 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00259496075962869 0.00902843315636096 2.02635548146384 0.666666666666667 8.1 8 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00259496075962869 0.00902843315636096 2.02635548146384 0.666666666666667 8.1 8 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.00948745598680138 0.0272190521556822 2.02635548146384 0.666666666666667 8.1 8 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.00948745598680138 0.0272190521556822 2.02635548146384 0.666666666666667 8.1 8 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00948745598680138 0.0272190521556822 2.02635548146384 0.666666666666667 8.1 8 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.26381095585423e-08 4.83791978143809e-07 2.00164382925087 0.658536585365854 8.1 8 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.26381095585423e-08 4.83791978143809e-07 2.00164382925087 0.658536585365854 8.1 8 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 8.75964327407469e-08 9.66276928605293e-07 1.97569659442724 0.65 8.1 8 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.000164207254148367 0.000822770854412414 1.97569659442724 0.65 8.1 8 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000164207254148367 0.000822770854412414 1.97569659442724 0.65 8.1 8 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000164207254148367 0.000822770854412414 1.97569659442724 0.65 8.1 8 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 1.1088533718982e-05 7.6970651132251e-05 1.95398564284013 0.642857142857143 8.1 8 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00199509860147752 0.00713322942186562 1.95398564284013 0.642857142857143 8.1 8 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.00199509860147752 0.00713322942186562 1.95398564284013 0.642857142857143 8.1 8 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00199509860147752 0.00713322942186562 1.95398564284013 0.642857142857143 8.1 8 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00199509860147752 0.00713322942186562 1.95398564284013 0.642857142857143 8.1 8 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00712563466779971 0.0209933294664161 1.93424841412458 0.636363636363636 8.1 8 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.00712563466779971 0.0209933294664161 1.93424841412458 0.636363636363636 8.1 8 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00712563466779971 0.0209933294664161 1.93424841412458 0.636363636363636 8.1 8 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00712563466779971 0.0209933294664161 1.93424841412458 0.636363636363636 8.1 8 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 1.82857526256567e-07 1.79452593009031e-06 1.92750887261195 0.634146341463415 8.1 8 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.90008262838035e-10 6.55050409553213e-09 1.92503770739065 0.633333333333333 8.1 8 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.90008262838035e-10 6.55050409553213e-09 1.92503770739065 0.633333333333333 8.1 8 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.90008262838035e-10 6.55050409553213e-09 1.92503770739065 0.633333333333333 8.1 8 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.90008262838035e-10 6.55050409553213e-09 1.92503770739065 0.633333333333333 8.1 8 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.90008262838035e-10 6.55050409553213e-09 1.92503770739065 0.633333333333333 8.1 8 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.90008262838035e-10 6.55050409553213e-09 1.92503770739065 0.633333333333333 8.1 8 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.90008262838035e-10 6.55050409553213e-09 1.92503770739065 0.633333333333333 8.1 8 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 8.67038114648214e-06 6.10789721358618e-05 1.92503770739065 0.633333333333333 8.1 8 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00043754544588965 0.00185312356576081 1.91970519296574 0.631578947368421 8.1 8 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00043754544588965 0.00185312356576081 1.91970519296574 0.631578947368421 8.1 8 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 6.96848882086314e-11 2.10982118980601e-09 1.91724403246194 0.630769230769231 8.1 8 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 2.91445016732449e-05 0.000185975900811783 1.91378017693807 0.62962962962963 8.1 8 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 6.72620165724235e-06 4.8097411850532e-05 1.89970826387235 0.625 8.1 8 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 9.83291437333174e-05 0.000536101040354447 1.89970826387235 0.625 8.1 8 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00151196601786577 0.00560293657141402 1.89970826387235 0.625 8.1 8 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.00151196601786577 0.00560293657141402 1.89970826387235 0.625 8.1 8 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00151196601786577 0.00560293657141402 1.89970826387235 0.625 8.1 8 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00151196601786577 0.00560293657141402 1.89970826387235 0.625 8.1 8 1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.0261705476853478 0.0614532827660889 1.89970826387235 0.625 8.1 8 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0261705476853478 0.0614532827660889 1.89970826387235 0.625 8.1 8 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0261705476853478 0.0614532827660889 1.89970826387235 0.625 8.1 8 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0261705476853478 0.0614532827660889 1.89970826387235 0.625 8.1 8 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.0261705476853478 0.0614532827660889 1.89970826387235 0.625 8.1 8 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0261705476853478 0.0614532827660889 1.89970826387235 0.625 8.1 8 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0261705476853478 0.0614532827660889 1.89970826387235 0.625 8.1 8 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.2897232661681e-11 1.32701656690374e-09 1.8942018631075 0.623188405797101 8.1 8 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000333229646487206 0.00150535170460728 1.88161580421642 0.619047619047619 8.1 8 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 8.63101091693193e-08 9.66276928605293e-07 1.87545666901441 0.617021276595745 8.1 8 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 7.51192689332291e-05 0.000427567119212677 1.8704819828897 0.615384615384615 8.1 8 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 7.51192689332291e-05 0.000427567119212677 1.8704819828897 0.615384615384615 8.1 8 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.00528546923545764 0.0163861061482706 1.8704819828897 0.615384615384615 8.1 8 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.00528546923545764 0.0163861061482706 1.8704819828897 0.615384615384615 8.1 8 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00528546923545764 0.0163861061482706 1.8704819828897 0.615384615384615 8.1 8 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.00528546923545764 0.0163861061482706 1.8704819828897 0.615384615384615 8.1 8 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00528546923545764 0.0163861061482706 1.8704819828897 0.615384615384615 8.1 8 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00528546923545764 0.0163861061482706 1.8704819828897 0.615384615384615 8.1 8 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00528546923545764 0.0163861061482706 1.8704819828897 0.615384615384615 8.1 8 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00528546923545764 0.0163861061482706 1.8704819828897 0.615384615384615 8.1 8 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 2.82827875448499e-07 2.71935180245414e-06 1.86516811362013 0.613636363636364 8.1 8 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 1.71892148516491e-05 0.000115378550631588 1.86293971682966 0.612903225806452 8.1 8 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00025196886619456 0.00121542947998257 1.85015065698872 0.608695652173913 8.1 8 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 5.7049179420742e-05 0.000336850549027867 1.84543088490457 0.607142857142857 8.1 8 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.30935468028857e-05 9.04471703908074e-05 1.84214134678531 0.606060606060606 8.1 8 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 7.08523488271481e-07 6.30143077381448e-06 1.83785729714162 0.604651162790698 8.1 8 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 1.2698411787204e-07 1.28154893426888e-06 1.82371993331746 0.6 8.1 8 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.000847552733501577 0.00339737335147252 1.82371993331746 0.6 8.1 8 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0187767873861313 0.0462831445785143 1.82371993331746 0.6 8.1 8 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00389467067789208 0.0127707958859076 1.82371993331746 0.6 8.1 8 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00389467067789208 0.0127707958859076 1.82371993331746 0.6 8.1 8 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00389467067789208 0.0127707958859076 1.82371993331746 0.6 8.1 8 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.10323809862512e-07 3.86682636711493e-06 1.81078574939322 0.595744680851064 8.1 8 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 1.7500712636776e-06 1.44787872570536e-05 1.80924596559271 0.595238095238095 8.1 8 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.13079651103583e-09 7.16844321366341e-08 1.80472285067873 0.59375 8.1 8 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000141991657675024 0.000731504088770773 1.8012048724123 0.592592592592593 8.1 8 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000630074506370965 0.00261398257307837 1.79608781311568 0.590909090909091 8.1 8 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000630074506370965 0.00261398257307837 1.79608781311568 0.590909090909091 8.1 8 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 6.67389865395344e-16 5.58644575563279e-14 1.78940262274428 0.588709677419355 8.1 8 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 6.67389865395344e-16 5.58644575563279e-14 1.78940262274428 0.588709677419355 8.1 8 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 6.67389865395344e-16 5.58644575563279e-14 1.78940262274428 0.588709677419355 8.1 8 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00285937729159539 0.00973419589937858 1.78796071893868 0.588235294117647 8.1 8 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00285937729159539 0.00973419589937858 1.78796071893868 0.588235294117647 8.1 8 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.00285937729159539 0.00973419589937858 1.78796071893868 0.588235294117647 8.1 8 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.00285937729159539 0.00973419589937858 1.78796071893868 0.588235294117647 8.1 8 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 4.31542953552804e-10 8.89979163631363e-09 1.78319282368818 0.586666666666667 8.1 8 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 4.20893100163101e-08 6.04980688416255e-07 1.78179533714924 0.586206896551724 8.1 8 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 4.20893100163101e-08 6.04980688416255e-07 1.78179533714924 0.586206896551724 8.1 8 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.000106061009421251 0.000571684910630455 1.78179533714924 0.586206896551724 8.1 8 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.000106061009421251 0.000571684910630455 1.78179533714924 0.586206896551724 8.1 8 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.25852442129055e-06 3.15618763098774e-05 1.7792389593341 0.585365853658537 8.1 8 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.25852442129055e-06 3.15618763098774e-05 1.7792389593341 0.585365853658537 8.1 8 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 1.36615961839018e-09 2.59206018262563e-08 1.77306104628086 0.583333333333333 8.1 8 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.000467064477640302 0.00196636908781701 1.77306104628086 0.583333333333333 8.1 8 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0134685781392391 0.0358678407237256 1.77306104628086 0.583333333333333 8.1 8 1 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.0134685781392391 0.0358678407237256 1.77306104628086 0.583333333333333 8.1 8 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0134685781392391 0.0358678407237256 1.77306104628086 0.583333333333333 8.1 8 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0134685781392391 0.0358678407237256 1.77306104628086 0.583333333333333 8.1 8 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0134685781392391 0.0358678407237256 1.77306104628086 0.583333333333333 8.1 8 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0134685781392391 0.0358678407237256 1.77306104628086 0.583333333333333 8.1 8 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0134685781392391 0.0358678407237256 1.77306104628086 0.583333333333333 8.1 8 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0134685781392391 0.0358678407237256 1.77306104628086 0.583333333333333 8.1 8 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 1.96684622993011e-12 9.65111098341567e-11 1.76789177209345 0.581632653061224 8.1 8 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.39697104110777e-08 3.62860616116633e-07 1.76489025804915 0.580645161290323 8.1 8 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 7.90382621966328e-05 0.000444551174331259 1.76489025804915 0.580645161290323 8.1 8 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.48817972778751e-12 7.5631419737201e-11 1.76292926887354 0.58 8.1 8 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.00209502691560257 0.00743447207207597 1.7597297602186 0.578947368421053 8.1 8 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00209502691560257 0.00743447207207597 1.7597297602186 0.578947368421053 8.1 8 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00209502691560257 0.00743447207207597 1.7597297602186 0.578947368421053 8.1 8 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00034552845819356 0.00155106307889412 1.75357685895909 0.576923076923077 8.1 8 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 5.87932768348226e-05 0.000342880462852265 1.75003427944604 0.575757575757576 8.1 8 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 4.42327640540266e-10 8.99188903555428e-09 1.74773160276256 0.575 8.1 8 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.45144418420796e-25 4.98343582018275e-23 1.74466480915272 0.573991031390135 8.1 8 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0002552482953474 0.00122295732080589 1.73687612696901 0.571428571428571 8.1 8 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00967263008076445 0.0274733584928699 1.73687612696901 0.571428571428571 8.1 8 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.00967263008076445 0.0274733584928699 1.73687612696901 0.571428571428571 8.1 8 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00967263008076445 0.0274733584928699 1.73687612696901 0.571428571428571 8.1 8 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 4.36709542613202e-05 0.000264441565590888 1.73687612696901 0.571428571428571 8.1 8 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 4.36709542613202e-05 0.000264441565590888 1.73687612696901 0.571428571428571 8.1 8 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00153331684952073 0.00566729838147533 1.73687612696901 0.571428571428571 8.1 8 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.33965152561415e-06 1.16239275667618e-05 1.73687612696901 0.571428571428571 8.1 8 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.00010500469776e-06 8.78487297336369e-06 1.72836202830739 0.568627450980392 8.1 8 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.41052785576725e-10 3.85996372837845e-09 1.72700751261123 0.568181818181818 8.1 8 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.38768217895059e-08 3.62860616116633e-07 1.72391436482745 0.567164179104478 8.1 8 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000188360752038966 0.000937193531998071 1.72240215924426 0.566666666666667 8.1 8 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 4.21162455898768e-06 3.1542851302313e-05 1.71799703863239 0.565217391304348 8.1 8 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0011216118386003 0.00433710229980495 1.71799703863239 0.565217391304348 8.1 8 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 7.87649474095349e-19 1.0189320014888e-16 1.71415536368017 0.563953488372093 8.1 8 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.26842396263973e-10 6.94174223706916e-09 1.71192101020221 0.563218390804598 8.1 8 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.13052955232585e-06 2.46118428340314e-05 1.70973743748512 0.5625 8.1 8 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.0069581480979259 0.0208451468281022 1.70973743748512 0.5625 8.1 8 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0069581480979259 0.0208451468281022 1.70973743748512 0.5625 8.1 8 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.0069581480979259 0.0208451468281022 1.70973743748512 0.5625 8.1 8 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.08009272402791e-14 1.28694432447466e-12 1.70681480938685 0.561538461538462 8.1 8 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000820298886113322 0.00330675726611687 1.70213860442963 0.56 8.1 8 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000820298886113322 0.00330675726611687 1.70213860442963 0.56 8.1 8 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000102368146739164 0.000555991880953552 1.69856268299175 0.558823529411765 8.1 8 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.31691874549214e-05 9.05302113447014e-05 1.69648365889996 0.558139534883721 8.1 8 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.02026923979126e-10 2.90368625644592e-09 1.69573958711974 0.557894736842105 8.1 8 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.02026923979126e-10 2.90368625644592e-09 1.69573958711974 0.557894736842105 8.1 8 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 1.72621994141993e-06 1.43649764715822e-05 1.69512429699379 0.557692307692308 8.1 8 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 1.72621994141993e-06 1.43649764715822e-05 1.69512429699379 0.557692307692308 8.1 8 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 7.5417671765553e-05 0.000427567119212677 1.68862956788653 0.555555555555556 8.1 8 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00501430843045763 0.0158211993271424 1.68862956788653 0.555555555555556 8.1 8 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00501430843045763 0.0158211993271424 1.68862956788653 0.555555555555556 8.1 8 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00501430843045763 0.0158211993271424 1.68862956788653 0.555555555555556 8.1 8 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.00501430843045763 0.0158211993271424 1.68862956788653 0.555555555555556 8.1 8 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00501430843045763 0.0158211993271424 1.68862956788653 0.555555555555556 8.1 8 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.00501430843045763 0.0158211993271424 1.68862956788653 0.555555555555556 8.1 8 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0470244123085308 0.101387482901575 1.68862956788653 0.555555555555556 8.1 8 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0470244123085308 0.101387482901575 1.68862956788653 0.555555555555556 8.1 8 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0470244123085308 0.101387482901575 1.68862956788653 0.555555555555556 8.1 8 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0470244123085308 0.101387482901575 1.68862956788653 0.555555555555556 8.1 8 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0470244123085308 0.101387482901575 1.68862956788653 0.555555555555556 8.1 8 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.000599949458841734 0.00251096494097585 1.68862956788653 0.555555555555556 8.1 8 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 7.20669158272456e-06 5.12756106110853e-05 1.68144391015085 0.553191489361702 8.1 8 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 9.40219999363569e-08 1.01358565082906e-06 1.67854819733199 0.552238805970149 8.1 8 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 9.40219999363569e-08 1.01358565082906e-06 1.67854819733199 0.552238805970149 8.1 8 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.000438863416487276 0.00185312356576081 1.6769838467287 0.551724137931034 8.1 8 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000438863416487276 0.00185312356576081 1.6769838467287 0.551724137931034 8.1 8 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 5.3284253123811e-06 3.8685455201624e-05 1.67484483672011 0.551020408163265 8.1 8 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 6.98140339166727e-08 9.55243944840627e-07 1.67394583251361 0.550724637681159 8.1 8 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 9.59014951791407e-11 2.84307974249827e-09 1.67174327220767 0.55 8.1 8 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.09065760992006e-05 0.000249828574202414 1.67174327220767 0.55 8.1 8 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 4.09065760992006e-05 0.000249828574202414 1.67174327220767 0.55 8.1 8 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00361971758261491 0.0120628995785972 1.67174327220767 0.55 8.1 8 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 9.93680793518171e-13 5.23706581176429e-11 1.66925185153374 0.549180327868853 8.1 8 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.93865832029987e-06 2.99717154534049e-05 1.6687633376761 0.549019607843137 8.1 8 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.93865832029987e-06 2.99717154534049e-05 1.6687633376761 0.549019607843137 8.1 8 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 3.8954616014842e-10 8.15182626310591e-09 1.66374450057031 0.547368421052632 8.1 8 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.93853806591513e-11 1.26713323266583e-09 1.66048574175509 0.546296296296296 8.1 8 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00261720766130045 0.00905618350606953 1.65792721210678 0.545454545454545 8.1 8 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00261720766130045 0.00905618350606953 1.65792721210678 0.545454545454545 8.1 8 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0327581706481292 0.0749435318847072 1.65792721210678 0.545454545454545 8.1 8 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.15169557501167e-10 5.46761214864572e-09 1.65792721210678 0.545454545454545 8.1 8 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 8.60691095698157e-08 9.66276928605293e-07 1.64641382868937 0.541666666666667 8.1 8 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00189516781064392 0.00686214705991426 1.64641382868937 0.541666666666667 8.1 8 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.69845140815087e-17 2.01408029483224e-15 1.64433764479443 0.540983606557377 8.1 8 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000126025409863347 0.000654504227137016 1.64299093091663 0.540540540540541 8.1 8 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000126025409863347 0.000654504227137016 1.64299093091663 0.540540540540541 8.1 8 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 6.40372877763214e-07 5.73113588086197e-06 1.64038300880406 0.53968253968254 8.1 8 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 6.51983642899317e-06 4.68572082750368e-05 1.63667173502849 0.538461538461538 8.1 8 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0230155385269842 0.0553228231822611 1.63667173502849 0.538461538461538 8.1 8 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0230155385269842 0.0553228231822611 1.63667173502849 0.538461538461538 8.1 8 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.61775501705556e-19 2.30206538927006e-17 1.63555835289581 0.538095238095238 8.1 8 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.22085392646538e-24 2.1715939217003e-22 1.63151415603155 0.536764705882353 8.1 8 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000997681570565966 0.00391102169398173 1.62832136903344 0.535714285714286 8.1 8 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000997681570565966 0.00391102169398173 1.62832136903344 0.535714285714286 8.1 8 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000997681570565966 0.00391102169398173 1.62832136903344 0.535714285714286 8.1 8 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.17756584388069e-10 6.85102453915488e-09 1.62108438517107 0.533333333333333 8.1 8 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 3.63893589642107e-05 0.000224164752407237 1.62108438517107 0.533333333333333 8.1 8 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.03893662831596e-07 1.07130929137218e-06 1.62108438517107 0.533333333333333 8.1 8 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.03893662831596e-07 1.07130929137218e-06 1.62108438517107 0.533333333333333 8.1 8 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.03893662831596e-07 1.07130929137218e-06 1.62108438517107 0.533333333333333 8.1 8 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.03893662831596e-07 1.07130929137218e-06 1.62108438517107 0.533333333333333 8.1 8 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.03893662831596e-07 1.07130929137218e-06 1.62108438517107 0.533333333333333 8.1 8 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0162760122554757 0.041284786879754 1.62108438517107 0.533333333333333 8.1 8 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0162760122554757 0.041284786879754 1.62108438517107 0.533333333333333 8.1 8 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0162760122554757 0.041284786879754 1.62108438517107 0.533333333333333 8.1 8 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0162760122554757 0.041284786879754 1.62108438517107 0.533333333333333 8.1 8 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0162760122554757 0.041284786879754 1.62108438517107 0.533333333333333 8.1 8 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.26215433396727e-14 8.16384371470646e-13 1.6147520242915 0.53125 8.1 8 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0115692652550477 0.0320917435827152 1.60916464704481 0.529411764705882 8.1 8 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0115692652550477 0.0320917435827152 1.60916464704481 0.529411764705882 8.1 8 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0115692652550477 0.0320917435827152 1.60916464704481 0.529411764705882 8.1 8 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.69370336882871e-14 2.1024559575373e-12 1.60688699007801 0.528662420382166 8.1 8 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 4.16807651348764e-07 3.9020874201927e-06 1.60661041744633 0.528571428571429 8.1 8 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.73568533352557e-14 1.62203342900287e-12 1.60579113625436 0.528301886792453 8.1 8 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 1.0562007679171e-05 7.36751810169623e-05 1.60579113625436 0.528301886792453 8.1 8 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 3.07218992766043e-07 2.91448417804053e-06 1.60419808949221 0.527777777777778 8.1 8 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000280095441028956 0.00129829254913422 1.60419808949221 0.527777777777778 8.1 8 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000280095441028956 0.00129829254913422 1.60419808949221 0.527777777777778 8.1 8 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.52908110189968e-10 4.10543850566649e-09 1.59975432747145 0.526315789473684 8.1 8 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000204333468463425 0.00100264319180501 1.59975432747145 0.526315789473684 8.1 8 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.00825795455807434 0.0240800601150406 1.59975432747145 0.526315789473684 8.1 8 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.18901626641036e-06 3.15395245878409e-05 1.59704287945879 0.525423728813559 8.1 8 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.18901626641036e-06 3.15395245878409e-05 1.59704287945879 0.525423728813559 8.1 8 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000108980479170443 0.000583004593456921 1.59213644972159 0.523809523809524 8.1 8 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.00591475838901849 0.0179844042469515 1.59213644972159 0.523809523809524 8.1 8 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.22476986624989e-06 1.06923160716171e-05 1.58781586234107 0.522388059701492 8.1 8 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.82723320979557e-05 0.000341240858334942 1.58584342027605 0.521739130434783 8.1 8 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 5.82723320979557e-05 0.000341240858334942 1.58584342027605 0.521739130434783 8.1 8 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00305960914555208 0.0103416242615691 1.5805572755418 0.52 8.1 8 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00305960914555208 0.0103416242615691 1.5805572755418 0.52 8.1 8 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0022080035369806 0.00779649884149727 1.57605426336076 0.518518518518518 8.1 8 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0022080035369806 0.00779649884149727 1.57605426336076 0.518518518518518 8.1 8 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00159641530707884 0.00583984314131927 1.57217235630815 0.517241379310345 8.1 8 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.61876860543029e-06 2.09354366602657e-05 1.56582014476751 0.515151515151515 8.1 8 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.000608925257744224 0.00254105760049862 1.56318851427211 0.514285714285714 8.1 8 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 1.16798776351006e-19 1.84671843052757e-17 1.56249097365887 0.514056224899598 8.1 8 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.48010020197924e-09 2.77129287817956e-08 1.5608413843708 0.513513513513513 8.1 8 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000234751271922206 0.00114010600663925 1.55683408941734 0.51219512195122 8.1 8 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.21244246555709e-07 1.23236116320553e-06 1.5551100206583 0.511627906976744 8.1 8 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 4.87441024722813e-05 0.000289011907575235 1.54956595641353 0.509803921568627 8.1 8 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 3.56633588627059e-05 0.000220647650702741 1.54844145281671 0.509433962264151 8.1 8 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.60584610998935e-06 1.35214142870701e-05 1.54058533179785 0.506849315068493 8.1 8 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 6.37533459121725e-07 5.73113588086197e-06 1.53900416313709 0.506329113924051 8.1 8 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 6.37533459121725e-07 5.73113588086197e-06 1.53900416313709 0.506329113924051 8.1 8 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 6.37533459121725e-07 5.73113588086197e-06 1.53900416313709 0.506329113924051 8.1 8 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.53640132704e-07 2.4553055022979e-06 1.53764621828727 0.505882352941176 8.1 8 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000191550743274796 0.00094974462606284 1.51976661109788 0.5 8.1 8 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.00341832550339525 0.0114184910594635 1.51976661109788 0.5 8.1 8 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.036358446973204 0.0814772756580618 1.51976661109788 0.5 8.1 8 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.036358446973204 0.0814772756580618 1.51976661109788 0.5 8.1 8 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.036358446973204 0.0814772756580618 1.51976661109788 0.5 8.1 8 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.036358446973204 0.0814772756580618 1.51976661109788 0.5 8.1 8 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.036358446973204 0.0814772756580618 1.51976661109788 0.5 8.1 8 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 3.79258967108059e-26 8.99475850324613e-24 1.51976661109788 0.5 8.1 8 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 4.53991676210802e-06 3.3473065038755e-05 1.51976661109788 0.5 8.1 8 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.56845056696236e-05 0.000106281197942259 1.51976661109788 0.5 8.1 8 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.000262676585603685 0.00125012970339145 1.51976661109788 0.5 8.1 8 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.00036052206467397 0.00159358810620524 1.51976661109788 0.5 8.1 8 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00129274016512298 0.00486658533060846 1.51976661109788 0.5 8.1 8 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00129274016512298 0.00486658533060846 1.51976661109788 0.5 8.1 8 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00474502057241776 0.0152075771949335 1.51976661109788 0.5 8.1 8 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0128961915335338 0.0354271825332404 1.51976661109788 0.5 8.1 8 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0181242220796378 0.0455667279493368 1.51976661109788 0.5 8.1 8 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0255938764130256 0.0609031540731361 1.51976661109788 0.5 8.1 8 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0255938764130256 0.0609031540731361 1.51976661109788 0.5 8.1 8 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0255938764130256 0.0609031540731361 1.51976661109788 0.5 8.1 8 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0255938764130256 0.0609031540731361 1.51976661109788 0.5 8.1 8 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0255938764130256 0.0609031540731361 1.51976661109788 0.5 8.1 8 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0520477631570193 0.10891759848888 1.51976661109788 0.5 8.1 8 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0520477631570193 0.10891759848888 1.51976661109788 0.5 8.1 8 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0520477631570193 0.10891759848888 1.51976661109788 0.5 8.1 8 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0752720372309302 0.149698453740701 1.51976661109788 0.5 8.1 8 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0752720372309302 0.149698453740701 1.51976661109788 0.5 8.1 8 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0752720372309302 0.149698453740701 1.51976661109788 0.5 8.1 8 1 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0752720372309302 0.149698453740701 1.51976661109788 0.5 8.1 8 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 6.48041488410672e-13 3.54678091541687e-11 1.51118035905778 0.497175141242938 8.1 8 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.07603613989006e-10 5.37127168557011e-09 1.50883303835617 0.496402877697842 8.1 8 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 7.59744539707019e-15 5.40558240001544e-13 1.50529264337314 0.495238095238095 8.1 8 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 9.23463681012196e-08 1.0108375523695e-06 1.504415433208 0.494949494949495 8.1 8 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.11981395025733e-12 3.72725653265038e-10 1.50123287193815 0.49390243902439 8.1 8 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.46087446451345e-06 1.24992399905816e-05 1.50100406034359 0.493827160493827 8.1 8 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.46087446451345e-06 1.24992399905816e-05 1.50100406034359 0.493827160493827 8.1 8 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 3.10535076226004e-10 6.7983294379939e-09 1.49805565951077 0.492857142857143 8.1 8 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 3.10535076226004e-10 6.7983294379939e-09 1.49805565951077 0.492857142857143 8.1 8 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.04787701851373e-09 2.04264246211649e-08 1.49673984426306 0.492424242424242 8.1 8 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 8.18288289505613e-34 3.88141411988829e-31 1.49087370974621 0.490494296577947 8.1 8 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.000394451848828937 0.00171129567342554 1.48599401974015 0.488888888888889 8.1 8 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 5.49825259470364e-15 4.11790181171751e-13 1.48569112654412 0.488789237668161 8.1 8 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.87198049368678e-09 6.80225708952628e-08 1.48386661241053 0.488188976377953 8.1 8 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000743403906298904 0.00304859872813643 1.48269913277842 0.48780487804878 8.1 8 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00102206060348602 0.00398463627057701 1.48079823645435 0.487179487179487 8.1 8 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00102206060348602 0.00398463627057701 1.48079823645435 0.487179487179487 8.1 8 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 8.13807726119832e-08 9.66276928605293e-07 1.47715633228205 0.485981308411215 8.1 8 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.03456526436962e-26 2.94437274239594e-24 1.4769562840247 0.485915492957746 8.1 8 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00193856535542514 0.00700146827606593 1.47634470792366 0.485714285714286 8.1 8 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 1.02496788162863e-16 1.12194561196734e-14 1.47300456152564 0.484615384615385 8.1 8 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00369725412319019 0.0122925061151861 1.47074188170763 0.483870967741935 8.1 8 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 8.8731879605531e-05 0.000485636402610272 1.46736086588761 0.482758620689655 8.1 8 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 8.8731879605531e-05 0.000485636402610272 1.46736086588761 0.482758620689655 8.1 8 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 8.8731879605531e-05 0.000485636402610272 1.46736086588761 0.482758620689655 8.1 8 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.3503945912815e-06 1.88961101886643e-05 1.46612778952972 0.482352941176471 8.1 8 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.82977682666308e-09 3.33816977479688e-08 1.46509874738932 0.482014388489209 8.1 8 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000165565146619961 0.000826663872421768 1.463478958835 0.481481481481481 8.1 8 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00710082210532372 0.0209933294664161 1.463478958835 0.481481481481481 8.1 8 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00710082210532372 0.0209933294664161 1.463478958835 0.481481481481481 8.1 8 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00710082210532372 0.0209933294664161 1.463478958835 0.481481481481481 8.1 8 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00710082210532372 0.0209933294664161 1.463478958835 0.481481481481481 8.1 8 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 6.15225776533857e-09 1.01798404652056e-07 1.46176025189567 0.480916030534351 8.1 8 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 6.15225776533857e-09 1.01798404652056e-07 1.46176025189567 0.480916030534351 8.1 8 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00987260246290485 0.0278192342667596 1.45897594665397 0.48 8.1 8 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00987260246290485 0.0278192342667596 1.45897594665397 0.48 8.1 8 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00987260246290485 0.0278192342667596 1.45897594665397 0.48 8.1 8 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00987260246290485 0.0278192342667596 1.45897594665397 0.48 8.1 8 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.48520588540935e-05 0.000101121912676436 1.45731044899797 0.479452054794521 8.1 8 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000423775476900174 0.00181090841930615 1.45644300230214 0.479166666666667 8.1 8 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000423775476900174 0.00181090841930615 1.45644300230214 0.479166666666667 8.1 8 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.000423775476900174 0.00181090841930615 1.45644300230214 0.479166666666667 8.1 8 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 2.7511982682196e-05 0.000176349330435878 1.45368980191971 0.478260869565217 8.1 8 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0137622229615195 0.0361989709320559 1.45368980191971 0.478260869565217 8.1 8 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0137622229615195 0.0361989709320559 1.45368980191971 0.478260869565217 8.1 8 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000795629422904815 0.00323480191083872 1.45068631059343 0.477272727272727 8.1 8 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000795629422904815 0.00323480191083872 1.45068631059343 0.477272727272727 8.1 8 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0192429489376386 0.0472931197551982 1.44739677247417 0.476190476190476 8.1 8 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.21425992567739e-15 9.59939930132735e-14 1.44406942357193 0.475095785440613 8.1 8 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.22597253612426e-09 2.35751205257407e-08 1.43977889472431 0.473684210526316 8.1 8 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.84604675158989e-07 1.7992633750085e-06 1.43835054264621 0.473214285714286 8.1 8 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00283402718576283 0.00973419589937858 1.43533513270355 0.472222222222222 8.1 8 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.00032832359196852 0.00148791232920766 1.4337420859414 0.471698113207547 8.1 8 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00390393268472931 0.0127707958859076 1.43036857515095 0.470588235294118 8.1 8 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00390393268472931 0.0127707958859076 1.43036857515095 0.470588235294118 8.1 8 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00390393268472931 0.0127707958859076 1.43036857515095 0.470588235294118 8.1 8 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0380601974423393 0.0837089041119765 1.43036857515095 0.470588235294118 8.1 8 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0380601974423393 0.0837089041119765 1.43036857515095 0.470588235294118 8.1 8 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0380601974423393 0.0837089041119765 1.43036857515095 0.470588235294118 8.1 8 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0380601974423393 0.0837089041119765 1.43036857515095 0.470588235294118 8.1 8 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0380601974423393 0.0837089041119765 1.43036857515095 0.470588235294118 8.1 8 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0380601974423393 0.0837089041119765 1.43036857515095 0.470588235294118 8.1 8 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0380601974423393 0.0837089041119765 1.43036857515095 0.470588235294118 8.1 8 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.01729765691158e-09 2.01057578581274e-08 1.42478119790426 0.46875 8.1 8 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00538485011710058 0.0166579167752916 1.42478119790426 0.46875 8.1 8 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 1.66986406873618e-05 0.000112616899043203 1.42357885090181 0.468354430379747 8.1 8 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 4.83570482974307e-07 4.4394890146609e-06 1.42216692047692 0.467889908256881 8.1 8 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.09912113900699e-16 2.13360670057639e-14 1.42121519263078 0.467576791808874 8.1 8 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 9.52396479188919e-06 6.67615857086617e-05 1.41373638241663 0.465116279069767 8.1 8 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00156992416780897 0.00578757018339939 1.41373638241663 0.465116279069767 8.1 8 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.73970414673017e-08 9.66276928605293e-07 1.41206661503583 0.464566929133858 8.1 8 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000343889473200787 0.00154859088723013 1.41121185316232 0.464285714285714 8.1 8 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 7.69927649560767e-05 0.000434764700525782 1.40963859580093 0.463768115942029 8.1 8 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.45728028280545e-44 2.07370984243215e-41 1.40286148716727 0.461538461538462 8.1 8 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 3.2108749729706e-05 0.000203070003846096 1.40286148716727 0.461538461538462 8.1 8 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0142676726547509 0.0373902360731317 1.40286148716727 0.461538461538462 8.1 8 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0769325271256209 0.151417684785281 1.40286148716727 0.461538461538462 8.1 8 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0769325271256209 0.151417684785281 1.40286148716727 0.461538461538462 8.1 8 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0769325271256209 0.151417684785281 1.40286148716727 0.461538461538462 8.1 8 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.0198205637461644 0.0482130977962255 1.39311939350639 0.458333333333333 8.1 8 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0198205637461644 0.0482130977962255 1.39311939350639 0.458333333333333 8.1 8 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0198205637461644 0.0482130977962255 1.39311939350639 0.458333333333333 8.1 8 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.000146899734018673 0.000751936408304216 1.38566955717748 0.455882352941176 8.1 8 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.81497188688483e-06 1.4928930607151e-05 1.38160601008898 0.454545454545455 8.1 8 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.000658754404758027 0.0027171232404947 1.38160601008898 0.454545454545455 8.1 8 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0276018154550569 0.0644948824179737 1.38160601008898 0.454545454545455 8.1 8 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.110700259383264 0.206456709177438 1.38160601008898 0.454545454545455 8.1 8 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.110700259383264 0.206456709177438 1.38160601008898 0.454545454545455 8.1 8 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.110700259383264 0.206456709177438 1.38160601008898 0.454545454545455 8.1 8 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.110700259383264 0.206456709177438 1.38160601008898 0.454545454545455 8.1 8 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 7.49107989254983e-09 1.19773108843802e-07 1.37991078799071 0.45398773006135 8.1 8 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.27303042055913e-09 7.32593046801884e-08 1.37672975358279 0.452941176470588 8.1 8 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.42925964575541e-05 9.77805998033632e-05 1.37269242292712 0.451612903225806 8.1 8 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0105194978042022 0.0294670184554719 1.37269242292712 0.451612903225806 8.1 8 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.0105194978042022 0.0294670184554719 1.37269242292712 0.451612903225806 8.1 8 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 4.62480261606044e-05 0.000278859920451441 1.37149669782004 0.451219512195122 8.1 8 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0385465030162813 0.08425756342883 1.36778994998809 0.45 8.1 8 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0385465030162813 0.08425756342883 1.36778994998809 0.45 8.1 8 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 7.9132460570912e-09 1.25117212658231e-07 1.36689067980401 0.449704142011834 8.1 8 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.000203929103517109 0.00100264319180501 1.36558738968215 0.449275362318841 8.1 8 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.56129125700071e-09 4.61356640343292e-08 1.36197663508225 0.448087431693989 8.1 8 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.43218505026481e-07 1.42517435421456e-06 1.36035053301069 0.447552447552448 8.1 8 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 4.72378469871744e-05 0.000282434690179619 1.3588501463934 0.447058823529412 8.1 8 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 4.72378469871744e-05 0.000282434690179619 1.3588501463934 0.447058823529412 8.1 8 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00773894019358462 0.0226129607709875 1.35090365430923 0.444444444444444 8.1 8 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0540089777325006 0.112343384490222 1.35090365430923 0.444444444444444 8.1 8 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0540089777325006 0.112343384490222 1.35090365430923 0.444444444444444 8.1 8 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0540089777325006 0.112343384490222 1.35090365430923 0.444444444444444 8.1 8 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 8.57964917067389e-05 0.000480663022435785 1.35090365430923 0.444444444444444 8.1 8 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00306997777923538 0.0103520814688435 1.35090365430923 0.444444444444444 8.1 8 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0200011530942927 0.0484041511108478 1.35090365430923 0.444444444444444 8.1 8 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0200011530942927 0.0484041511108478 1.35090365430923 0.444444444444444 8.1 8 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 6.45608925860525e-05 0.000371943927732602 1.3430495632958 0.441860465116279 8.1 8 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.010594796906443 0.029561560780134 1.34097053920401 0.441176470588235 8.1 8 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.010594796906443 0.029561560780134 1.34097053920401 0.441176470588235 8.1 8 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00092254473324225 0.00365677202062318 1.33945531825576 0.440677966101695 8.1 8 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.65043467628354e-09 1.35269984003862e-07 1.33805538585792 0.440217391304348 8.1 8 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.76544188682722e-07 4.4033920811397e-06 1.33653233883785 0.439716312056738 8.1 8 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.000116747464742843 0.00061392208936708 1.33442921950058 0.439024390243902 8.1 8 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0056897127588561 0.0173371761367285 1.33442921950058 0.439024390243902 8.1 8 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0056897127588561 0.0173371761367285 1.33442921950058 0.439024390243902 8.1 8 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0056897127588561 0.0173371761367285 1.33442921950058 0.439024390243902 8.1 8 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0056897127588561 0.0173371761367285 1.33442921950058 0.439024390243902 8.1 8 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0759702336364756 0.150146725645423 1.32979578471065 0.4375 8.1 8 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0759702336364756 0.150146725645423 1.32979578471065 0.4375 8.1 8 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0759702336364756 0.150146725645423 1.32979578471065 0.4375 8.1 8 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 8.74530786418606e-05 0.000485585925331369 1.32761221199355 0.436781609195402 8.1 8 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 8.74530786418606e-05 0.000485585925331369 1.32761221199355 0.436781609195402 8.1 8 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00168575814587995 0.00611947408568155 1.32634176968542 0.436363636363636 8.1 8 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 1.52266653367284e-06 1.28973480798599e-05 1.32551072847635 0.43609022556391 8.1 8 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.000117348424671712 0.00061392208936708 1.32309093201463 0.435294117647059 8.1 8 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.000117348424671712 0.00061392208936708 1.32309093201463 0.435294117647059 8.1 8 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.000117348424671712 0.00061392208936708 1.32309093201463 0.435294117647059 8.1 8 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00418359097240567 0.0135918948715372 1.32153618356337 0.434782608695652 8.1 8 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0382476558347012 0.083861963409522 1.32153618356337 0.434782608695652 8.1 8 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0382476558347012 0.083861963409522 1.32153618356337 0.434782608695652 8.1 8 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 4.82935758087534e-06 3.54235867916784e-05 1.3204529571834 0.434426229508197 8.1 8 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000283242901538912 0.00130861898990218 1.31979732016395 0.434210526315789 8.1 8 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.71641211119442e-06 2.15947175096629e-05 1.31948729025552 0.434108527131783 8.1 8 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000157404312536605 0.000797104401208502 1.31835175902467 0.433734939759036 8.1 8 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000157404312536605 0.000797104401208502 1.31835175902467 0.433734939759036 8.1 8 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 8.76989338089682e-05 0.000485585925331369 1.3171310629515 0.433333333333333 8.1 8 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0198926126091539 0.0483057811311023 1.3171310629515 0.433333333333333 8.1 8 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00124250869585235 0.0047877398921594 1.30265709522675 0.428571428571429 8.1 8 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0143716604436941 0.0375245372685811 1.30265709522675 0.428571428571429 8.1 8 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0143716604436941 0.0375245372685811 1.30265709522675 0.428571428571429 8.1 8 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0272827785447658 0.0638542662322398 1.30265709522675 0.428571428571429 8.1 8 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0272827785447658 0.0638542662322398 1.30265709522675 0.428571428571429 8.1 8 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.107363087239934 0.202354533963477 1.30265709522675 0.428571428571429 8.1 8 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.107363087239934 0.202354533963477 1.30265709522675 0.428571428571429 8.1 8 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00768737690457455 0.0225085130354107 1.30265709522675 0.428571428571429 8.1 8 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0530241685752634 0.110797932279882 1.30265709522675 0.428571428571429 8.1 8 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.92969620752683e-08 6.87740951304969e-07 1.30033506831904 0.427807486631016 8.1 8 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000156407690962037 0.000797104401208502 1.29777822970156 0.426966292134831 8.1 8 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.5479071943419e-28 5.50667984387131e-26 1.29598535594262 0.426376440460948 8.1 8 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.00166899618315409 0.00607412165889582 1.29553875044409 0.426229508196721 8.1 8 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 8.55437440776902e-07 7.56079179022069e-06 1.29425285590271 0.425806451612903 8.1 8 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0195753414504931 0.0480270877311237 1.28949894274972 0.424242424242424 8.1 8 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.000278652135909443 0.00129829254913422 1.28733171763585 0.423529411764706 8.1 8 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.000278652135909443 0.00129829254913422 1.28733171763585 0.423529411764706 8.1 8 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.000278652135909443 0.00129829254913422 1.28733171763585 0.423529411764706 8.1 8 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.000278652135909443 0.00129829254913422 1.28733171763585 0.423529411764706 8.1 8 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.000278652135909443 0.00129829254913422 1.28733171763585 0.423529411764706 8.1 8 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 6.43335276101076e-05 0.000371943927732602 1.28595636323667 0.423076923076923 8.1 8 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0374408597227831 0.0832474115398755 1.28595636323667 0.423076923076923 8.1 8 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.000115171621267109 0.000613817292371145 1.28475115577347 0.422680412371134 8.1 8 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.00757267516214692 0.0222642908176344 1.28335847159377 0.422222222222222 8.1 8 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 4.78541761228404e-05 0.000284922563275322 1.28273879101839 0.422018348623853 8.1 8 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00164788456991758 0.00601266600767364 1.28230307811384 0.421875 8.1 8 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0141120797161021 0.0370507185166296 1.27980346197716 0.421052631578947 8.1 8 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0736490612841044 0.147401707745824 1.27980346197716 0.421052631578947 8.1 8 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0736490612841044 0.147401707745824 1.27980346197716 0.421052631578947 8.1 8 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000275124889639165 0.00129829254913422 1.27798555933231 0.420454545454545 8.1 8 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.64884305740839e-05 0.00017055672718064 1.27711479924192 0.420168067226891 8.1 8 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00049519024817068 0.0020786304517607 1.27585345129205 0.419753086419753 8.1 8 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000894035767159466 0.00356362155929389 1.27331797146039 0.418918918918919 8.1 8 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000894035767159466 0.00356362155929389 1.27331797146039 0.418918918918919 8.1 8 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.92511143546164e-06 1.57438711072524e-05 1.2696784345881 0.417721518987342 8.1 8 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.94178414216616e-05 0.000127924020106595 1.26846662028642 0.417322834645669 8.1 8 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.152594899544868 0.274406984619018 1.2664721759149 0.416666666666667 8.1 8 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.152594899544868 0.274406984619018 1.2664721759149 0.416666666666667 8.1 8 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.152594899544868 0.274406984619018 1.2664721759149 0.416666666666667 8.1 8 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.152594899544868 0.274406984619018 1.2664721759149 0.416666666666667 8.1 8 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.152594899544868 0.274406984619018 1.2664721759149 0.416666666666667 8.1 8 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00294935314231291 0.0100165382374971 1.2664721759149 0.416666666666667 8.1 8 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 3.39530364710882e-05 0.000212288186155881 1.26029426286166 0.414634146341463 8.1 8 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.00158696254876309 0.00582022604868526 1.25923519205253 0.414285714285714 8.1 8 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00394085977381368 0.0128620262801304 1.25773788504652 0.413793103448276 8.1 8 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.33633761623742e-08 6.17060842790585e-07 1.25726146918097 0.413636363636364 8.1 8 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.000352262967082925 0.00157632139043711 1.25545937438521 0.41304347826087 8.1 8 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00995758625863153 0.0280032514743729 1.25545937438521 0.41304347826087 8.1 8 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.102507258972371 0.194231464071483 1.25157250325708 0.411764705882353 8.1 8 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.102507258972371 0.194231464071483 1.25157250325708 0.411764705882353 8.1 8 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000142393979332048 0.000731504088770773 1.24990151193097 0.411214953271028 8.1 8 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 5.59741599716802e-06 4.04320962638075e-05 1.24698798859313 0.41025641025641 8.1 8 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0185394252335637 0.0462831445785143 1.24698798859313 0.41025641025641 8.1 8 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.00025427159655817 0.00122239351994012 1.24620862110026 0.41 8.1 8 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.000139027634353476 0.000719404813399986 1.24344540908008 0.409090909090909 8.1 8 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00966380971452676 0.0274733584928699 1.24062580497786 0.408163265306122 8.1 8 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.00966380971452676 0.0274733584928699 1.24062580497786 0.408163265306122 8.1 8 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.0015083824875928 0.00560293657141402 1.23980960379038 0.407894736842105 8.1 8 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00110823300163844 0.00429704512624387 1.23832834978346 0.407407407407407 8.1 8 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00146470112494427 0.00549939235038444 1.23120333050968 0.40506329113924 8.1 8 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0178993616503219 0.0450810471299258 1.23028725660305 0.404761904761905 8.1 8 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00263878695345223 0.00909199475729425 1.22425643671774 0.402777777777778 8.1 8 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.000307547088000503 0.00141174034266037 1.22149465938708 0.401869158878505 8.1 8 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 5.28273418841648e-10 1.05877897888967e-08 1.22140752180259 0.401840490797546 8.1 8 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00476964044442939 0.0152521311290405 1.2158132888783 0.4 8.1 8 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00900469359107171 0.0259912352537425 1.2158132888783 0.4 8.1 8 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00900469359107171 0.0259912352537425 1.2158132888783 0.4 8.1 8 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0970507667959866 0.187131763076814 1.2158132888783 0.4 8.1 8 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.0970507667959866 0.187131763076814 1.2158132888783 0.4 8.1 8 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.0970507667959866 0.187131763076814 1.2158132888783 0.4 8.1 8 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 1.99154676966551e-05 0.000130597744388665 1.2158132888783 0.4 8.1 8 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.00654497385199587 0.0198159527476386 1.2158132888783 0.4 8.1 8 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0472530320356279 0.101462772270505 1.2158132888783 0.4 8.1 8 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.142984760499078 0.263217741513827 1.2158132888783 0.4 8.1 8 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.142984760499078 0.263217741513827 1.2158132888783 0.4 8.1 8 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.24961652006452e-14 8.16384371470646e-13 1.20670607323128 0.397003745318352 8.1 8 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.00629706678331883 0.0191060256559972 1.20616397706181 0.396825396825397 8.1 8 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0165039184988996 0.0417883915016621 1.20314856711916 0.395833333333333 8.1 8 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0449840170139616 0.0978780676007147 1.19739187541045 0.393939393939394 8.1 8 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.00830053099739434 0.0241054196108003 1.19588192348686 0.39344262295082 8.1 8 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00830053099739434 0.0241054196108003 1.19588192348686 0.39344262295082 8.1 8 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0914377899298155 0.177997229918095 1.18938256520704 0.391304347826087 8.1 8 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.0304746902769201 0.0710909578099301 1.18615930622274 0.390243902439024 8.1 8 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00554271064078025 0.0170720286619703 1.18204069752057 0.388888888888889 8.1 8 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00554271064078025 0.0170720286619703 1.18204069752057 0.388888888888889 8.1 8 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.133369801579561 0.247116181832963 1.18204069752057 0.388888888888889 8.1 8 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.133369801579561 0.247116181832963 1.18204069752057 0.388888888888889 8.1 8 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 0.000418470661898494 0.0018044962178229 1.18064513589422 0.388429752066116 8.1 8 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 0.000418470661898494 0.0018044962178229 1.18064513589422 0.388429752066116 8.1 8 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00759167614826953 0.0222741343484279 1.17952035488194 0.388059701492537 8.1 8 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.020835987395669 0.0502535763797237 1.17859451472897 0.387755102040816 8.1 8 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0602578410606158 0.12409103882671 1.1765935053661 0.387096774193548 8.1 8 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.50447149294907e-34 1.07043146723326e-31 1.16950406741683 0.384764364105875 8.1 8 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0198062994177737 0.0482130977962255 1.16905123930606 0.384615384615385 8.1 8 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0198062994177737 0.0482130977962255 1.16905123930606 0.384615384615385 8.1 8 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0858946249843043 0.167895674934979 1.16905123930606 0.384615384615385 8.1 8 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.199883882306897 0.343105867940549 1.16905123930606 0.384615384615385 8.1 8 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.199883882306897 0.343105867940549 1.16905123930606 0.384615384615385 8.1 8 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.199883882306897 0.343105867940549 1.16905123930606 0.384615384615385 8.1 8 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00690283900031504 0.0208108896132379 1.16584835919837 0.383561643835616 8.1 8 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00247933154480153 0.00873289304022915 1.16407655318136 0.382978723404255 8.1 8 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0568216278222584 0.117184313610252 1.16217446731014 0.382352941176471 8.1 8 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.000640587029358479 0.00264987018249162 1.16144765400976 0.382113821138211 8.1 8 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.0187994782616875 0.0462831445785143 1.16054904847475 0.381818181818182 8.1 8 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00657075884188341 0.0198517830828028 1.1598218874168 0.381578947368421 8.1 8 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00458559230955224 0.0147297920011125 1.15791741797934 0.380952380952381 8.1 8 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00458559230955224 0.0147297920011125 1.15791741797934 0.380952380952381 8.1 8 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.00898040216710419 0.0259912352537425 1.15587883097585 0.380281690140845 8.1 8 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0259897271895123 0.0614532827660889 1.15502262443439 0.38 8.1 8 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.0178217655482297 0.0449651992466859 1.15292639462598 0.379310344827586 8.1 8 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0805383344670334 0.158295649097498 1.15292639462598 0.379310344827586 8.1 8 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.000786781358410226 0.00321721227878664 1.15208114067097 0.379032258064516 8.1 8 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0168774081720142 0.0426581737633681 1.14605351000824 0.377049180327869 8.1 8 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.32567943374953e-06 2.56809914342252e-05 1.14585577820872 0.376984126984127 8.1 8 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.32567943374953e-06 2.56809914342252e-05 1.14585577820872 0.376984126984127 8.1 8 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.32567943374953e-06 2.56809914342252e-05 1.14585577820872 0.376984126984127 8.1 8 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.31480872726361e-10 3.66857415469826e-09 1.14212763500689 0.375757575757576 8.1 8 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.46688199467824e-06 1.24992399905816e-05 1.14119658883884 0.375451263537906 8.1 8 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.0232227913354127 0.0557268668976262 1.13982495832341 0.375 8.1 8 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.00262202923717544 0.00905618350606953 1.13982495832341 0.375 8.1 8 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.0340162294710908 0.0776967809588478 1.13982495832341 0.375 8.1 8 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0503099485018424 0.105903930056393 1.13982495832341 0.375 8.1 8 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0754278224399737 0.149698453740701 1.13982495832341 0.375 8.1 8 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0754278224399737 0.149698453740701 1.13982495832341 0.375 8.1 8 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.115454545206083 0.214760546180727 1.13982495832341 0.375 8.1 8 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.18319347661664 0.316748866616621 1.13982495832341 0.375 8.1 8 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.18319347661664 0.316748866616621 1.13982495832341 0.375 8.1 8 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.52045589444209e-09 2.80988147765077e-08 1.13812118409572 0.374439461883408 8.1 8 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.36046741150189e-11 6.04982852052247e-10 1.13383638586287 0.373029772329247 8.1 8 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0472732382398769 0.101462772270505 1.13098910593331 0.372093023255814 8.1 8 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00157610976749009 0.00579535968769611 1.13040491734553 0.371900826446281 8.1 8 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.020684582362447 0.0499731081523975 1.12756877597585 0.370967741935484 8.1 8 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.107344017310442 0.202354533963477 1.12575304525769 0.37037037037037 8.1 8 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.107344017310442 0.202354533963477 1.12575304525769 0.37037037037037 8.1 8 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.000108173323502099 0.000580870337145235 1.12399405612447 0.369791666666667 8.1 8 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.000196950275725761 0.000973125841519994 1.10816315392554 0.364583333333333 8.1 8 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.0366812150119862 0.0816860234147987 1.10528480807119 0.363636363636364 8.1 8 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0366812150119862 0.0816860234147987 1.10528480807119 0.363636363636364 8.1 8 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0366812150119862 0.0816860234147987 1.10528480807119 0.363636363636364 8.1 8 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.0366812150119862 0.0816860234147987 1.10528480807119 0.363636363636364 8.1 8 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.154726800186908 0.275910071009987 1.10528480807119 0.363636363636364 8.1 8 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.154726800186908 0.275910071009987 1.10528480807119 0.363636363636364 8.1 8 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0928242826834092 0.180203211812403 1.10528480807119 0.363636363636364 8.1 8 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0928242826834092 0.180203211812403 1.10528480807119 0.363636363636364 8.1 8 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00081984407198722 0.00330675726611687 1.10352480041502 0.363057324840764 8.1 8 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0863572642318285 0.168337516440948 1.09760921912625 0.361111111111111 8.1 8 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0863572642318285 0.168337516440948 1.09760921912625 0.361111111111111 8.1 8 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0504890179196797 0.106123888478145 1.09423195999047 0.36 8.1 8 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.142564786084528 0.263125409336295 1.09423195999047 0.36 8.1 8 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.142564786084528 0.263125409336295 1.09423195999047 0.36 8.1 8 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0472150266375557 0.101462772270505 1.08964398531546 0.358490566037736 8.1 8 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.251284324010766 0.404957636542832 1.08554757935563 0.357142857142857 8.1 8 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.251284324010766 0.404957636542832 1.08554757935563 0.357142857142857 8.1 8 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.000249616732972726 0.00120817894904826 1.08554757935563 0.357142857142857 8.1 8 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0413044923287305 0.0900096364223331 1.08186775705273 0.355932203389831 8.1 8 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 4.69220832303047e-08 6.6109034095766e-07 1.0811347843176 0.355691056910569 8.1 8 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.227204140786241 0.379919497460425 1.07277643136321 0.352941176470588 8.1 8 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.227204140786241 0.379919497460425 1.07277643136321 0.352941176470588 8.1 8 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.227204140786241 0.379919497460425 1.07277643136321 0.352941176470588 8.1 8 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.0316669906609751 0.0737514365148404 1.07025817682949 0.352112676056338 8.1 8 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0564632828005859 0.116614298149831 1.0694653929948 0.351851851851852 8.1 8 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.0564632828005859 0.116614298149831 1.0694653929948 0.351851851851852 8.1 8 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.206521741087152 0.351952619840739 1.06383662776852 0.35 8.1 8 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.206521741087152 0.351952619840739 1.06383662776852 0.35 8.1 8 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.206521741087152 0.351952619840739 1.06383662776852 0.35 8.1 8 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.206521741087152 0.351952619840739 1.06383662776852 0.35 8.1 8 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.2012973300058e-09 8.81124535785507e-08 1.0588731598318 0.348367029548989 8.1 8 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0831993199961336 0.163075251176995 1.0572289468507 0.347826086956522 8.1 8 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.18848093899069 0.324707477220039 1.0572289468507 0.347826086956522 8.1 8 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.172566636078764 0.299831896385935 1.05214611537546 0.346153846153846 8.1 8 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.172566636078764 0.299831896385935 1.05214611537546 0.346153846153846 8.1 8 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0135859213985159 0.0358678407237256 1.05002056766763 0.345454545454545 8.1 8 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000297065550944186 0.00136803973784329 1.04893695511069 0.345098039215686 8.1 8 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.054079563159383 0.112343384490222 1.04483954512979 0.34375 8.1 8 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.145727194154593 0.267336441822733 1.04483954512979 0.34375 8.1 8 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.134308545890437 0.248531938624306 1.0421256761814 0.342857142857143 8.1 8 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 6.28291249051198e-12 2.98019482466618e-10 1.04056092291386 0.342342342342342 8.1 8 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.123981005944674 0.230319806082599 1.03984031285644 0.342105263157895 8.1 8 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.11493449547725 0.214073019717443 1.01317774073192 0.333333333333333 8.1 8 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.145785719504175 0.267336441822733 1.01317774073192 0.333333333333333 8.1 8 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.172178649890185 0.299831896385935 1.01317774073192 0.333333333333333 8.1 8 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.172178649890185 0.299831896385935 1.01317774073192 0.333333333333333 8.1 8 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.187707747759115 0.323767424316632 1.01317774073192 0.333333333333333 8.1 8 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.205177945462924 0.351345627429292 1.01317774073192 0.333333333333333 8.1 8 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.205177945462924 0.351345627429292 1.01317774073192 0.333333333333333 8.1 8 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.224994135882994 0.377555018114977 1.01317774073192 0.333333333333333 8.1 8 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.224994135882994 0.377555018114977 1.01317774073192 0.333333333333333 8.1 8 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.247710582626359 0.40055927167876 1.01317774073192 0.333333333333333 8.1 8 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.274121310389582 0.430071251030181 1.01317774073192 0.333333333333333 8.1 8 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.274121310389582 0.430071251030181 1.01317774073192 0.333333333333333 8.1 8 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.305434105766611 0.466845040285593 1.01317774073192 0.333333333333333 8.1 8 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.305434105766611 0.466845040285593 1.01317774073192 0.333333333333333 8.1 8 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.305434105766611 0.466845040285593 1.01317774073192 0.333333333333333 8.1 8 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.305434105766611 0.466845040285593 1.01317774073192 0.333333333333333 8.1 8 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.305434105766611 0.466845040285593 1.01317774073192 0.333333333333333 8.1 8 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.305434105766611 0.466845040285593 1.01317774073192 0.333333333333333 8.1 8 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.305434105766611 0.466845040285593 1.01317774073192 0.333333333333333 8.1 8 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00558771708844141 0.01717348038197 1.00289167229809 0.32994923857868 8.1 8 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0552219504669816 0.114382584446164 1.00125800260566 0.329411764705882 8.1 8 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0552219504669816 0.114382584446164 1.00125800260566 0.329411764705882 8.1 8 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0682294866212089 0.137082910904981 0.999846454669658 0.328947368421053 8.1 8 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.144115950837981 0.264957361811947 0.991152137672531 0.326086956521739 8.1 8 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.184265495179893 0.318215776263335 0.985794558549977 0.324324324324324 8.1 8 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0669886545069888 0.135984101802347 0.97940514937419 0.322222222222222 8.1 8 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.082748883821135 0.162416085072379 0.975652639223331 0.320987654320988 8.1 8 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.152953942982391 0.274406984619018 0.972650631102643 0.32 8.1 8 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.263784418141096 0.415227021034048 0.972650631102643 0.32 8.1 8 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.110474213487989 0.206456709177438 0.969126534613141 0.318840579710145 8.1 8 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.291103014431435 0.450260423408622 0.967124207062288 0.318181818181818 8.1 8 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.323004884376199 0.482810872339633 0.959852596482872 0.315789473684211 8.1 8 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.360998028107506 0.524606502584579 0.949854131936175 0.3125 8.1 8 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.360998028107506 0.524606502584579 0.949854131936175 0.3125 8.1 8 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.360998028107506 0.524606502584579 0.949854131936175 0.3125 8.1 8 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.360998028107506 0.524606502584579 0.949854131936175 0.3125 8.1 8 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0958756007280276 0.185620380729229 0.947811434878248 0.311827956989247 8.1 8 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0411814499731541 0.0898791461837397 0.943954416830982 0.31055900621118 8.1 8 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0456202797412479 0.0991109283538867 0.938127537714741 0.308641975308642 8.1 8 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0485882041136941 0.103971450306446 0.936711496148379 0.308176100628931 8.1 8 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0485882041136941 0.103971450306446 0.936711496148379 0.308176100628931 8.1 8 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.304325654613243 0.466845040285593 0.93524099144485 0.307692307692308 8.1 8 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.304325654613243 0.466845040285593 0.93524099144485 0.307692307692308 8.1 8 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.304325654613243 0.466845040285593 0.93524099144485 0.307692307692308 8.1 8 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.304325654613243 0.466845040285593 0.93524099144485 0.307692307692308 8.1 8 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.230948170503763 0.385274615037344 0.925075328494362 0.304347826086957 8.1 8 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.250639166032967 0.404834884523169 0.918928648570811 0.302325581395349 8.1 8 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.27244425562168 0.428384724585249 0.911859966658728 0.3 8.1 8 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0935165822780947 0.181299859103173 0.902055020780677 0.296774193548387 8.1 8 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.178153266838292 0.309161095988889 0.898043906557839 0.295454545454545 8.1 8 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.098291601243489 0.189267860039898 0.895077267885868 0.294478527607362 8.1 8 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.416745481158033 0.593622442130011 0.893980359469341 0.294117647058824 8.1 8 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.416745481158033 0.593622442130011 0.893980359469341 0.294117647058824 8.1 8 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.416745481158033 0.593622442130011 0.893980359469341 0.294117647058824 8.1 8 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.287506579576287 0.445181569898865 0.88653052314043 0.291666666666667 8.1 8 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.381708540429489 0.552003305925979 0.88653052314043 0.291666666666667 8.1 8 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.381708540429489 0.552003305925979 0.88653052314043 0.291666666666667 8.1 8 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.354145044424346 0.524606502584579 0.882445129024576 0.290322580645161 8.1 8 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.331149373000074 0.493947125554617 0.879864880109299 0.289473684210526 8.1 8 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.311298196466876 0.4723775927411 0.878087375300998 0.288888888888889 8.1 8 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.14892432703726 0.2727404342008 0.877611705000184 0.288732394366197 8.1 8 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.170518906410419 0.297728102849112 0.868438063484503 0.285714285714286 8.1 8 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.423012491049562 0.599941137795141 0.868438063484503 0.285714285714286 8.1 8 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.180735976645065 0.313261016767268 0.865268581500983 0.284671532846715 8.1 8 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.327282182143361 0.488691023284368 0.853202307984775 0.280701754385965 8.1 8 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.42756792131942 0.599941137795141 0.851069302214813 0.28 8.1 8 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.42756792131942 0.599941137795141 0.851069302214813 0.28 8.1 8 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.42756792131942 0.599941137795141 0.851069302214813 0.28 8.1 8 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.220671823594814 0.371177310845651 0.849281341495874 0.279411764705882 8.1 8 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.471600931453591 0.634298795329358 0.844314783943267 0.277777777777778 8.1 8 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.236000734545223 0.391920063574085 0.843082207616343 0.277372262773723 8.1 8 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.431028803400665 0.599941137795141 0.838491923364348 0.275862068965517 8.1 8 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.401964272393967 0.575447846696796 0.835871636103834 0.275 8.1 8 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.472478544781359 0.634669632595391 0.828963606053389 0.272727272727273 8.1 8 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.433742309508834 0.599941137795141 0.828963606053389 0.272727272727273 8.1 8 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.38715936468678 0.558750279867433 0.820191504402031 0.26984126984127 8.1 8 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.394912614575418 0.565922105277765 0.807977185646974 0.265822784810127 8.1 8 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.318220968922613 0.476160293140776 0.805065556149147 0.264864864864865 8.1 8 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.524670948266946 0.702358193211538 0.799877163735727 0.263157894736842 8.1 8 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.472768665179982 0.634669632595391 0.788027131680382 0.259259259259259 8.1 8 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.386366601856933 0.558172258317173 0.782712417732814 0.257510729613734 8.1 8 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.229133742199428 0.382696379283786 0.773968947310335 0.254634146341463 8.1 8 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.492892457268312 0.661061231567208 0.767558894493879 0.252525252525253 8.1 8 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.560357590674859 0.742447720233077 0.75988330554894 0.25 8.1 8 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.514648074513873 0.689589651632054 0.75988330554894 0.25 8.1 8 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.57525252052257 0.74416757882147 0.75988330554894 0.25 8.1 8 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.561065917628787 0.742694698405362 0.747426202179285 0.245901639344262 8.1 8 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.582052900853904 0.752280906371576 0.738172353961828 0.242857142857143 8.1 8 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.600649114045815 0.773515079621362 0.73102697749012 0.240506329113924 8.1 8 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.61097898444664 0.783970329005923 0.729487973326983 0.24 8.1 8 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.61097898444664 0.783970329005923 0.729487973326983 0.24 8.1 8 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.622827529732885 0.79568729843627 0.723698386237086 0.238095238095238 8.1 8 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.622827529732885 0.79568729843627 0.723698386237086 0.238095238095238 8.1 8 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.622827529732885 0.79568729843627 0.723698386237086 0.238095238095238 8.1 8 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.640547981056817 0.811664984010553 0.709224418512344 0.233333333333333 8.1 8 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.640547981056817 0.811664984010553 0.709224418512344 0.233333333333333 8.1 8 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.678821040910222 0.839302498761677 0.703891904087439 0.231578947368421 8.1 8 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.656005036267804 0.830511714065023 0.701430743583637 0.230769230769231 8.1 8 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.675480281874235 0.839302498761677 0.697597788700666 0.229508196721311 8.1 8 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.66704781942451 0.839302498761677 0.690803005044491 0.227272727272727 8.1 8 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.769271666508595 0.919121394997256 0.685748348910019 0.225609756097561 8.1 8 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.717798268572686 0.874509363166895 0.667214609750289 0.219512195121951 8.1 8 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.747154757447833 0.908162070506561 0.664897892355323 0.21875 8.1 8 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.707714607575915 0.867422813592185 0.660768091781687 0.217391304347826 8.1 8 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.896911761083521 1 0.655585596944184 0.215686274509804 8.1 8 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.83827349925293 0.972971606392267 0.63830197666111 0.21 8.1 8 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.778199262792381 0.929008012544931 0.607906644439152 0.2 8.1 8 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.788850728377501 0.940146219833487 0.607906644439152 0.2 8.1 8 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.788850728377501 0.940146219833487 0.607906644439152 0.2 8.1 8 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.815630807415716 0.954734731959363 0.58829675268305 0.193548387096774 8.1 8 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.808156042100988 0.951204340702818 0.584525619653031 0.192307692307692 8.1 8 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.845143224254459 0.980145727884348 0.57504682582082 0.189189189189189 8.1 8 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.834793761493011 0.971309503356136 0.562876522628845 0.185185185185185 8.1 8 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.858321490219937 0.994618469530106 0.542773789677815 0.178571428571429 8.1 8 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.997047906788985 1 0.50658887036596 0.166666666666667 8.1 8 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999584012117547 1 0.476240228362469 0.15668202764977 8.1 8 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.956219685781594 1 0.434219031742252 0.142857142857143 8.1 8 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.974952754950723 1 0.434219031742252 0.142857142857143 8.1 8 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.974670600744161 1 0.399938581867863 0.131578947368421 8.1 8 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.390469003355123 0.128463476070529 8.1 8 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.986417438322011 1 0.388025517727118 0.127659574468085 8.1 8 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99999999919361 1 0.383858577029877 0.126288659793814 8.1 8 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.988702066277291 1 0.37994165277447 0.125 8.1 8 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.998653665505741 1 0.342482616585438 0.112676056338028 8.1 8 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999118708869 1 0.328131427396133 0.107954545454545 8.1 8 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.995638973082051 1 0.323354598105932 0.106382978723404 8.1 8 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.996445590152372 1 0.316618043978725 0.104166666666667 8.1 8 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.316045497787082 0.103978300180832 8.1 8 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999999909915 1 0.303953322219576 0.1 8.1 8 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.999989338651281 1 0.281438261314422 0.0925925925925926 8.1 8 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.999184570228893 1 0.276321202017796 0.0909090909090909 8.1 8 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999998478882523 1 0.202635548146384 0.0666666666666667 8.1 8 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0392197835122034 0.0129032258064516 8.1 8 1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.000103328645627882 0.000727904270933049 4.48017621145374 0.857142857142857 9.1 9 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 1.86845639224433e-11 8.57681756826996e-10 4.27653183820585 0.818181818181818 9.1 9 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 1.45787166359855e-05 0.000128058726993872 4.18149779735683 0.8 9.1 9 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 2.0215790979022e-06 2.09978617249258e-05 4.02067095899695 0.769230769230769 9.1 9 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.000356660909131583 0.00215969563274146 3.92015418502203 0.75 9.1 9 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.000356660909131583 0.00215969563274146 3.92015418502203 0.75 9.1 9 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00168191956630674 0.00845714326096992 3.73348017621145 0.714285714285714 9.1 9 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 2.71288810241128e-05 0.000215667026241969 3.61860386309725 0.692307692307692 9.1 9 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000118103087811268 0.000816325906123389 3.48458149779736 0.666666666666667 9.1 9 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.000923817639170846 0.00486886111311153 3.48458149779736 0.666666666666667 9.1 9 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.000923817639170846 0.00486886111311153 3.48458149779736 0.666666666666667 9.1 9 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 6.50734766065942e-05 0.000477317305212286 3.36013215859031 0.642857142857143 9.1 9 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.000496111701493312 0.00279948445638914 3.32619142971566 0.636363636363636 9.1 9 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000496111701493312 0.00279948445638914 3.32619142971566 0.636363636363636 9.1 9 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.000496111701493312 0.00279948445638914 3.32619142971566 0.636363636363636 9.1 9 1 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00389068399493201 0.0172474869931098 3.26679515418502 0.625 9.1 9 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00389068399493201 0.0172474869931098 3.26679515418502 0.625 9.1 9 1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00389068399493201 0.0172474869931098 3.26679515418502 0.625 9.1 9 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.000263661818670716 0.00166751452430413 3.21653676719756 0.615384615384615 9.1 9 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.000263661818670716 0.00166751452430413 3.21653676719756 0.615384615384615 9.1 9 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 1.90898747519397e-05 0.000164635707709153 3.19419970631424 0.611111111111111 9.1 9 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000139409897188544 0.000953751363938932 3.13612334801762 0.6 9.1 9 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.000139409897188544 0.000953751363938932 3.13612334801762 0.6 9.1 9 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00199515688559331 0.00968978924300097 3.13612334801762 0.6 9.1 9 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00199515688559331 0.00968978924300097 3.13612334801762 0.6 9.1 9 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 2.52564576775377e-09 7.1542644608706e-08 3.10786998452197 0.594594594594595 9.1 9 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 1.74793309546412e-08 3.14849214537397e-07 3.07463073335061 0.588235294117647 9.1 9 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 7.35267858592057e-05 0.000528427354937625 3.07463073335061 0.588235294117647 9.1 9 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 3.20082451926427e-11 1.33963920320972e-09 3.04900881057269 0.583333333333333 9.1 9 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00102532376064818 0.00536410188015573 3.04900881057269 0.583333333333333 9.1 9 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 1.55701207806676e-06 1.64120606451037e-05 3.01550321924771 0.576923076923077 9.1 9 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 2.03971140230245e-05 0.00017380295362134 2.98678414096916 0.571428571428571 9.1 9 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000528446274756212 0.00293741816007066 2.98678414096916 0.571428571428571 9.1 9 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000528446274756212 0.00293741816007066 2.98678414096916 0.571428571428571 9.1 9 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 4.40516638694047e-07 5.18062129637709e-06 2.96189427312775 0.566666666666667 9.1 9 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 5.65773260671458e-06 5.4033244962113e-05 2.92704845814978 0.56 9.1 9 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.50438034067193e-09 4.45986088495031e-08 2.90381791483113 0.555555555555556 9.1 9 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.000141572924743288 0.000954778539856392 2.90381791483113 0.555555555555556 9.1 9 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.000141572924743288 0.000954778539856392 2.90381791483113 0.555555555555556 9.1 9 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000141572924743288 0.000954778539856392 2.90381791483113 0.555555555555556 9.1 9 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.00759926693963345 0.0295457837570994 2.90381791483113 0.555555555555556 9.1 9 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 5.25534715340024e-09 1.35970163623428e-07 2.85102122547056 0.545454545454545 9.1 9 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 3.82995244086509e-05 0.000288360969489472 2.85102122547056 0.545454545454545 9.1 9 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.04419065568037e-05 9.52489296816133e-05 2.81446967129787 0.538461538461538 9.1 9 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00191392935962188 0.00939145337497217 2.81446967129787 0.538461538461538 9.1 9 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.000973059277690691 0.00510945886403636 2.78766519823789 0.533333333333333 9.1 9 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000497729843616621 0.00279948445638914 2.76716766001555 0.529411764705882 9.1 9 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 6.83632382920351e-05 0.000498876349177262 2.72706378088489 0.521739130434783 9.1 9 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.54974221622015e-05 0.000271394150013483 2.71797356828194 0.52 9.1 9 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 3.54974221622015e-05 0.000271394150013483 2.71797356828194 0.52 9.1 9 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 3.54974221622015e-05 0.000271394150013483 2.71797356828194 0.52 9.1 9 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.78328527163223e-10 6.85841876089908e-09 2.65491923641703 0.507936507936508 9.1 9 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 6.05529377675991e-05 0.000451135237923003 2.61343612334802 0.5 9.1 9 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000438120790908231 0.00257622266720006 2.61343612334802 0.5 9.1 9 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000438120790908231 0.00257622266720006 2.61343612334802 0.5 9.1 9 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00329941244448754 0.0151453674467928 2.61343612334802 0.5 9.1 9 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00329941244448754 0.0151453674467928 2.61343612334802 0.5 9.1 9 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00329941244448754 0.0151453674467928 2.61343612334802 0.5 9.1 9 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00329941244448754 0.0151453674467928 2.61343612334802 0.5 9.1 9 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00329941244448754 0.0151453674467928 2.61343612334802 0.5 9.1 9 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0132033769936736 0.0448410631551253 2.61343612334802 0.5 9.1 9 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0132033769936736 0.0448410631551253 2.61343612334802 0.5 9.1 9 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0132033769936736 0.0448410631551253 2.61343612334802 0.5 9.1 9 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000853886762489955 0.00453388381725077 2.61343612334802 0.5 9.1 9 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.000853886762489955 0.00453388381725077 2.61343612334802 0.5 9.1 9 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.00656269845237846 0.0266060395946853 2.61343612334802 0.5 9.1 9 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 8.83307597968188e-13 5.46498570395101e-11 2.58268981601451 0.494117647058824 9.1 9 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.94126575902604e-09 7.75077995387789e-08 2.52913173227228 0.483870967741935 9.1 9 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 4.82393945077851e-07 5.5358595471434e-06 2.49980846581115 0.478260869565217 9.1 9 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.000716385577960077 0.00384685538655543 2.48898678414097 0.476190476190476 9.1 9 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00139213056055581 0.00717754270895261 2.47588685369812 0.473684210526316 9.1 9 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00139213056055581 0.00717754270895261 2.47588685369812 0.473684210526316 9.1 9 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 7.57048778571462e-09 1.76603346214293e-07 2.45009636563877 0.46875 9.1 9 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 7.6931945771799e-07 8.48636890180388e-06 2.44662105164495 0.468085106382979 9.1 9 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00533497146543478 0.0226616847621304 2.43920704845815 0.466666666666667 9.1 9 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00533497146543478 0.0226616847621304 2.43920704845815 0.466666666666667 9.1 9 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 5.22243793831409e-06 5.02130350420334e-05 2.42220908993231 0.463414634146341 9.1 9 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.000304193661745148 0.00189025144394474 2.41240257539817 0.461538461538462 9.1 9 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000304193661745148 0.00189025144394474 2.41240257539817 0.461538461538462 9.1 9 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0105473576747412 0.0379971898003969 2.41240257539817 0.461538461538462 9.1 9 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0105473576747412 0.0379971898003969 2.41240257539817 0.461538461538462 9.1 9 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0105473576747412 0.0379971898003969 2.41240257539817 0.461538461538462 9.1 9 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0105473576747412 0.0379971898003969 2.41240257539817 0.461538461538462 9.1 9 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 2.23631955068939e-08 3.89173540070149e-07 2.40602055800294 0.46031746031746 9.1 9 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00058436494813768 0.00319827431230738 2.39564977973568 0.458333333333333 9.1 9 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.00058436494813768 0.00319827431230738 2.39564977973568 0.458333333333333 9.1 9 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00058436494813768 0.00319827431230738 2.39564977973568 0.458333333333333 9.1 9 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 3.56645861226432e-05 0.000271394150013483 2.38942731277533 0.457142857142857 9.1 9 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 1.48502226295657e-07 1.88677382159572e-06 2.38418734059819 0.456140350877193 9.1 9 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0210445152329738 0.0648189289535102 2.37585102122547 0.454545454545455 9.1 9 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0210445152329738 0.0648189289535102 2.37585102122547 0.454545454545455 9.1 9 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0210445152329738 0.0648189289535102 2.37585102122547 0.454545454545455 9.1 9 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0210445152329738 0.0648189289535102 2.37585102122547 0.454545454545455 9.1 9 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0210445152329738 0.0648189289535102 2.37585102122547 0.454545454545455 9.1 9 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0210445152329738 0.0648189289535102 2.37585102122547 0.454545454545455 9.1 9 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00217268400844928 0.0104450315676464 2.35209251101322 0.45 9.1 9 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.51328936507806e-08 2.76078303398215e-07 2.34830492242865 0.449275362318841 9.1 9 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.48845834112046e-06 3.45707336278484e-05 2.33541100384291 0.446808510638298 9.1 9 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.55946573386007e-06 6.10073185574045e-05 2.3230543318649 0.444444444444444 9.1 9 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.000467849388592725 0.00272162579807888 2.3230543318649 0.444444444444444 9.1 9 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 5.46457285512886e-05 0.000409267745939388 2.3230543318649 0.444444444444444 9.1 9 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00420860996418497 0.0184998392027176 2.3230543318649 0.444444444444444 9.1 9 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000103320123527851 0.000727904270933049 2.30597305001296 0.441176470588235 9.1 9 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000195418149138707 0.00128147477522756 2.28675660792952 0.4375 9.1 9 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.000195418149138707 0.00128147477522756 2.28675660792952 0.4375 9.1 9 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00818319731542182 0.030969919627248 2.28675660792952 0.4375 9.1 9 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00818319731542182 0.030969919627248 2.28675660792952 0.4375 9.1 9 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.00818319731542182 0.030969919627248 2.28675660792952 0.4375 9.1 9 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.00818319731542182 0.030969919627248 2.28675660792952 0.4375 9.1 9 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00818319731542182 0.030969919627248 2.28675660792952 0.4375 9.1 9 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00818319731542182 0.030969919627248 2.28675660792952 0.4375 9.1 9 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00170616459454358 0.00848906369942487 2.27255315073741 0.434782608695652 9.1 9 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.00170616459454358 0.00848906369942487 2.27255315073741 0.434782608695652 9.1 9 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.2488256662412e-06 2.30221505256204e-05 2.26826531460394 0.433962264150943 9.1 9 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.000369731415074485 0.00221062102374367 2.26497797356828 0.433333333333333 9.1 9 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.000369731415074485 0.00221062102374367 2.26497797356828 0.433333333333333 9.1 9 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 8.19690485102904e-05 0.000583209780150716 2.26026907965234 0.432432432432432 9.1 9 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 8.19690485102904e-05 0.000583209780150716 2.26026907965234 0.432432432432432 9.1 9 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.50418409753381e-13 1.7817269853953e-11 2.25157573703829 0.430769230769231 9.1 9 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.78025469939577e-09 7.60827391776957e-08 2.24877061776457 0.430232558139535 9.1 9 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 3.45082573990232e-05 0.000268334700977104 2.24008810572687 0.428571428571429 9.1 9 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00326490783131619 0.0151453674467928 2.24008810572687 0.428571428571429 9.1 9 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00326490783131619 0.0151453674467928 2.24008810572687 0.428571428571429 9.1 9 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.78804911826603e-06 1.87087786418571e-05 2.24008810572687 0.428571428571429 9.1 9 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.000699729703091131 0.00377164911931318 2.24008810572687 0.428571428571429 9.1 9 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0159833165974315 0.0524061279219931 2.24008810572687 0.428571428571429 9.1 9 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.08486268803419e-08 5.69878392654181e-07 2.23013215859031 0.426666666666667 9.1 9 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.08486268803419e-08 5.69878392654181e-07 2.23013215859031 0.426666666666667 9.1 9 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.08486268803419e-08 5.69878392654181e-07 2.23013215859031 0.426666666666667 9.1 9 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.08486268803419e-08 5.69878392654181e-07 2.23013215859031 0.426666666666667 9.1 9 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.08486268803419e-08 5.69878392654181e-07 2.23013215859031 0.426666666666667 9.1 9 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 6.45206324529806e-05 0.000475714300417572 2.22142070484581 0.425 9.1 9 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 7.55086305413351e-08 1.01366774773887e-06 2.2196306801038 0.424657534246575 9.1 9 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 9.82681236856223e-20 2.33059233341068e-17 2.21519823788546 0.423809523809524 9.1 9 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 7.54288908829479e-09 1.76603346214293e-07 2.21373412801244 0.423529411764706 9.1 9 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 7.54288908829479e-09 1.76603346214293e-07 2.21373412801244 0.423529411764706 9.1 9 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 6.17102498545126e-06 5.81547586377295e-05 2.21136902744832 0.423076923076923 9.1 9 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.39514577194803e-09 4.22402645421712e-08 2.20078831439833 0.421052631578947 9.1 9 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.39514577194803e-09 4.22402645421712e-08 2.20078831439833 0.421052631578947 9.1 9 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00625695862136982 0.026264460525691 2.20078831439833 0.421052631578947 9.1 9 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 5.96802249002994e-09 1.48991157952853e-07 2.19766219463356 0.420454545454545 9.1 9 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 2.55860371204298e-08 4.26868537810195e-07 2.19399575787241 0.419753086419753 9.1 9 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.56407229447927e-09 7.1542644608706e-08 2.1919141679693 0.419354838709677 9.1 9 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 6.47755382400932e-15 6.14503939437684e-13 2.18875275330396 0.41875 9.1 9 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.74472742007557e-07 5.53421894980945e-06 2.1843645210073 0.417910447761194 9.1 9 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 4.93777235424495e-13 3.34592860004312e-11 2.1809970525782 0.41726618705036 9.1 9 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 2.12224042563848e-05 0.000178695155365891 2.17786343612335 0.416666666666667 9.1 9 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000225073239460665 0.00146246219065081 2.17786343612335 0.416666666666667 9.1 9 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.000225073239460665 0.00146246219065081 2.17786343612335 0.416666666666667 9.1 9 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0313886700762562 0.0867619882712569 2.17786343612335 0.416666666666667 9.1 9 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0313886700762562 0.0867619882712569 2.17786343612335 0.416666666666667 9.1 9 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0313886700762562 0.0867619882712569 2.17786343612335 0.416666666666667 9.1 9 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0313886700762562 0.0867619882712569 2.17786343612335 0.416666666666667 9.1 9 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0313886700762562 0.0867619882712569 2.17786343612335 0.416666666666667 9.1 9 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 8.63735425556165e-09 1.98241211381681e-07 2.17296936098599 0.415730337078652 9.1 9 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 3.69784600227938e-08 5.48128631379538e-07 2.1672397120447 0.414634146341463 9.1 9 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.11574325713997e-13 4.60259211586826e-11 2.16541850220264 0.414285714285714 9.1 9 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 6.82762819604108e-10 2.36968656657718e-08 2.16111064046086 0.413461538461538 9.1 9 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.97018955681909e-11 1.28078173919805e-09 2.15986456475043 0.413223140495868 9.1 9 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.97018955681909e-11 1.28078173919805e-09 2.15986456475043 0.413223140495868 9.1 9 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 2.93340133660109e-10 1.04355752549584e-08 2.1578830376268 0.412844036697248 9.1 9 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 6.77792609674617e-08 9.18570365301886e-07 2.15608480176211 0.4125 9.1 9 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.000419778463976301 0.00248893647599282 2.15224151334543 0.411764705882353 9.1 9 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.000419778463976301 0.00248893647599282 2.15224151334543 0.411764705882353 9.1 9 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.0120091001240371 0.0417822725586915 2.15224151334543 0.411764705882353 9.1 9 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0120091001240371 0.0417822725586915 2.15224151334543 0.411764705882353 9.1 9 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.0120091001240371 0.0417822725586915 2.15224151334543 0.411764705882353 9.1 9 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.0120091001240371 0.0417822725586915 2.15224151334543 0.411764705882353 9.1 9 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0120091001240371 0.0417822725586915 2.15224151334543 0.411764705882353 9.1 9 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.8979653407875e-08 4.34084703151643e-07 2.15224151334543 0.411764705882353 9.1 9 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 2.8979653407875e-08 4.34084703151643e-07 2.15224151334543 0.411764705882353 9.1 9 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 2.8979653407875e-08 4.34084703151643e-07 2.15224151334543 0.411764705882353 9.1 9 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.8979653407875e-08 4.34084703151643e-07 2.15224151334543 0.411764705882353 9.1 9 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 2.8979653407875e-08 4.34084703151643e-07 2.15224151334543 0.411764705882353 9.1 9 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 2.8979653407875e-08 4.34084703151643e-07 2.15224151334543 0.411764705882353 9.1 9 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.8979653407875e-08 4.34084703151643e-07 2.15224151334543 0.411764705882353 9.1 9 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 2.8979653407875e-08 4.34084703151643e-07 2.15224151334543 0.411764705882353 9.1 9 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.65279305483995e-05 0.000143410031526661 2.15224151334543 0.411764705882353 9.1 9 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.65279305483995e-05 0.000143410031526661 2.15224151334543 0.411764705882353 9.1 9 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.90963255633064e-07 3.5088195997106e-06 2.14802969042303 0.410958904109589 9.1 9 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.24091797382094e-07 1.60529661522472e-06 2.14435784479837 0.41025641025641 9.1 9 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.82772775969414e-11 8.57681756826996e-10 2.14013666793853 0.409448818897638 9.1 9 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 7.26464056321457e-05 0.000524750432561134 2.13826591910292 0.409090909090909 9.1 9 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 7.26464056321457e-05 0.000524750432561134 2.13826591910292 0.409090909090909 9.1 9 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00474621589975523 0.0206540220958767 2.13826591910292 0.409090909090909 9.1 9 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00474621589975523 0.0206540220958767 2.13826591910292 0.409090909090909 9.1 9 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 3.04644099694638e-05 0.000239507488323464 2.1334172435494 0.408163265306122 9.1 9 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.2099912342556e-22 3.44363505269144e-20 2.13302507126199 0.408088235294118 9.1 9 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 9.67871023622967e-08 1.27525969131063e-06 2.12946647087616 0.407407407407407 9.1 9 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.64647761485344e-12 1.50637505837458e-10 2.12808370044053 0.407142857142857 9.1 9 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 2.29468300072365e-06 2.33238136430697e-05 2.12341685022026 0.40625 9.1 9 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.000322644278745012 0.00199618612458327 2.11900226217407 0.405405405405405 9.1 9 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.76539384767328e-07 2.18448299586007e-06 2.11721407461105 0.40506329113924 9.1 9 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.76539384767328e-07 2.18448299586007e-06 2.11721407461105 0.40506329113924 9.1 9 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.76539384767328e-07 2.18448299586007e-06 2.11721407461105 0.40506329113924 9.1 9 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 4.19584394695154e-06 4.11771443897382e-05 2.10760977689356 0.403225806451613 9.1 9 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.50034201242113e-08 4.23569843294674e-07 2.1021116644321 0.402173913043478 9.1 9 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000247133218811932 0.00158410166833053 2.09074889867841 0.4 9.1 9 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000247133218811932 0.00158410166833053 2.09074889867841 0.4 9.1 9 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.00145417991995302 0.00741683880320122 2.09074889867841 0.4 9.1 9 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.00358384825385178 0.0161386584342756 2.09074889867841 0.4 9.1 9 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00897980836331685 0.0331903046779218 2.09074889867841 0.4 9.1 9 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00897980836331685 0.0331903046779218 2.09074889867841 0.4 9.1 9 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00897980836331685 0.0331903046779218 2.09074889867841 0.4 9.1 9 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00897980836331685 0.0331903046779218 2.09074889867841 0.4 9.1 9 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00897980836331685 0.0331903046779218 2.09074889867841 0.4 9.1 9 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00897980836331685 0.0331903046779218 2.09074889867841 0.4 9.1 9 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.023082213352096 0.069868700663894 2.09074889867841 0.4 9.1 9 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.023082213352096 0.069868700663894 2.09074889867841 0.4 9.1 9 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.023082213352096 0.069868700663894 2.09074889867841 0.4 9.1 9 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.023082213352096 0.069868700663894 2.09074889867841 0.4 9.1 9 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.17657045345178e-10 8.15068356647865e-09 2.08224991941549 0.398373983739837 9.1 9 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.4998406929258e-06 2.52288886952724e-05 2.07537574501166 0.397058823529412 9.1 9 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.000188796779690417 0.00124957124418355 2.06643786497285 0.395348837209302 9.1 9 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.48480603586788e-07 4.13239915753333e-06 2.06493718387992 0.395061728395062 9.1 9 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.48480603586788e-07 4.13239915753333e-06 2.06493718387992 0.395061728395062 9.1 9 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 3.45357075251915e-12 1.82015969660546e-10 2.06323904474844 0.394736842105263 9.1 9 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000454441126601866 0.00266119227635578 2.06323904474844 0.394736842105263 9.1 9 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00110202284679581 0.00574424363000159 2.05907088506207 0.393939393939394 9.1 9 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00269889430529921 0.012759224572893 2.0534140969163 0.392857142857143 9.1 9 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00269889430529921 0.012759224572893 2.0534140969163 0.392857142857143 9.1 9 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00269889430529921 0.012759224572893 2.0534140969163 0.392857142857143 9.1 9 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00670053459596274 0.0269898340342166 2.04529783566367 0.391304347826087 9.1 9 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 3.48064640526977e-06 3.45707336278484e-05 2.04529783566367 0.391304347826087 9.1 9 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.24461764751725e-08 2.76078303398215e-07 2.04096916299559 0.39047619047619 9.1 9 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000345269321885194 0.00211775105621824 2.03975502310089 0.390243902439024 9.1 9 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000345269321885194 0.00211775105621824 2.03975502310089 0.390243902439024 9.1 9 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.85586732517231e-12 1.563038155277e-10 2.03815144210789 0.389937106918239 9.1 9 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000833554538553033 0.00445920341489085 2.03267254038179 0.388888888888889 9.1 9 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0169730484075795 0.0543329220117396 2.03267254038179 0.388888888888889 9.1 9 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0169730484075795 0.0543329220117396 2.03267254038179 0.388888888888889 9.1 9 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0169730484075795 0.0543329220117396 2.03267254038179 0.388888888888889 9.1 9 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0169730484075795 0.0543329220117396 2.03267254038179 0.388888888888889 9.1 9 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0169730484075795 0.0543329220117396 2.03267254038179 0.388888888888889 9.1 9 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 6.28251976804155e-06 5.88159580915995e-05 2.02833848379249 0.388059701492537 9.1 9 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.04594386119362e-13 7.83356902357118e-12 2.02791218314436 0.387978142076503 9.1 9 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.04440291339765e-09 3.37769396764741e-08 2.02330538581782 0.387096774193548 9.1 9 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.04440291339765e-09 3.37769396764741e-08 2.02330538581782 0.387096774193548 9.1 9 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.04440291339765e-09 3.37769396764741e-08 2.02330538581782 0.387096774193548 9.1 9 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.000629661715560314 0.00343298322315068 2.01033547949848 0.384615384615385 9.1 9 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.00499591835094168 0.0214132283535844 2.01033547949848 0.384615384615385 9.1 9 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00499591835094168 0.0214132283535844 2.01033547949848 0.384615384615385 9.1 9 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00499591835094168 0.0214132283535844 2.01033547949848 0.384615384615385 9.1 9 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.044414490327203 0.109535216179567 2.01033547949848 0.384615384615385 9.1 9 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.044414490327203 0.109535216179567 2.01033547949848 0.384615384615385 9.1 9 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.044414490327203 0.109535216179567 2.01033547949848 0.384615384615385 9.1 9 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.044414490327203 0.109535216179567 2.01033547949848 0.384615384615385 9.1 9 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.09991322919752e-07 5.75966390884767e-06 2.00566028070894 0.383720930232558 9.1 9 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 2.67142998144078e-05 0.000213564318179227 2.00363436123348 0.383333333333333 9.1 9 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 2.67142998144078e-05 0.000213564318179227 2.00363436123348 0.383333333333333 9.1 9 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 2.67142998144078e-05 0.000213564318179227 2.00363436123348 0.383333333333333 9.1 9 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 2.67142998144078e-05 0.000213564318179227 2.00363436123348 0.383333333333333 9.1 9 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 2.67142998144078e-05 0.000213564318179227 2.00363436123348 0.383333333333333 9.1 9 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 2.67142998144078e-05 0.000213564318179227 2.00363436123348 0.383333333333333 9.1 9 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 2.67142998144078e-05 0.000213564318179227 2.00363436123348 0.383333333333333 9.1 9 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00152436460758883 0.00771946916939113 1.9985099766779 0.382352941176471 9.1 9 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.71151181063698e-11 8.39821140184975e-10 1.99753079491568 0.382165605095541 9.1 9 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000475212952580446 0.00273782687860923 1.99118942731278 0.380952380952381 9.1 9 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 6.95475920570217e-07 7.792616023397e-06 1.98260671426401 0.379310344827586 9.1 9 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.44863251731322e-08 4.19807719534543e-07 1.9777354446958 0.378378378378378 9.1 9 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 4.12750312894694e-11 1.678124843569e-09 1.9768298881735 0.378205128205128 9.1 9 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.89059884429265e-10 1.04355752549584e-08 1.97378392532578 0.377622377622378 9.1 9 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.55813697567417e-15 4.63302065456025e-13 1.9688666758855 0.376681614349776 9.1 9 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 5.47945573124046e-17 7.08842318686834e-15 1.96776366934439 0.376470588235294 9.1 9 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 1.23765247769377e-06 1.31431304161062e-05 1.96776366934439 0.376470588235294 9.1 9 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 9.41924999386419e-07 1.02317501841746e-05 1.96007709251101 0.375 9.1 9 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0320216229741005 0.0867619882712569 1.96007709251101 0.375 9.1 9 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0320216229741005 0.0867619882712569 1.96007709251101 0.375 9.1 9 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0320216229741005 0.0867619882712569 1.96007709251101 0.375 9.1 9 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0320216229741005 0.0867619882712569 1.96007709251101 0.375 9.1 9 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.00864640809993e-07 1.31679251259284e-06 1.96007709251101 0.375 9.1 9 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000270231650047793 0.00169400721593837 1.96007709251101 0.375 9.1 9 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000270231650047793 0.00169400721593837 1.96007709251101 0.375 9.1 9 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00921638531978313 0.0338013306960087 1.96007709251101 0.375 9.1 9 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00921638531978313 0.0338013306960087 1.96007709251101 0.375 9.1 9 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 7.68484188339484e-08 1.02201214953933e-06 1.95397093334431 0.373831775700935 9.1 9 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.34376713442563e-07 2.850581736998e-06 1.95347750634094 0.373737373737374 9.1 9 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.34376713442563e-07 2.850581736998e-06 1.95347750634094 0.373737373737374 9.1 9 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0068091007858635 0.0269898340342166 1.93587860988742 0.37037037037037 9.1 9 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0068091007858635 0.0269898340342166 1.93587860988742 0.37037037037037 9.1 9 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0068091007858635 0.0269898340342166 1.93587860988742 0.37037037037037 9.1 9 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000484163779372617 0.00276692794396479 1.9316701781268 0.369565217391304 9.1 9 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.000484163779372617 0.00276692794396479 1.9316701781268 0.369565217391304 9.1 9 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 9.07277952002882e-06 8.32939694000065e-05 1.92568977509854 0.368421052631579 9.1 9 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00154710304736852 0.00780683559009009 1.92568977509854 0.368421052631579 9.1 9 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0232241007828685 0.069868700663894 1.92568977509854 0.368421052631579 9.1 9 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0232241007828685 0.069868700663894 1.92568977509854 0.368421052631579 9.1 9 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0232241007828685 0.069868700663894 1.92568977509854 0.368421052631579 9.1 9 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.56863372896396e-14 4.06322862269732e-12 1.92198889788823 0.367713004484305 9.1 9 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 2.11813764463215e-05 0.000178695155365891 1.91406589315629 0.366197183098592 9.1 9 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.61512982570125e-08 4.27739050801481e-07 1.91227033415709 0.365853658536585 9.1 9 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00373513259937794 0.0167141310972164 1.90068081698038 0.363636363636364 9.1 9 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0169255012745395 0.0543329220117396 1.90068081698038 0.363636363636364 9.1 9 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0169255012745395 0.0543329220117396 1.90068081698038 0.363636363636364 9.1 9 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00277261438720901 0.0130643386523126 1.88748164464023 0.361111111111111 9.1 9 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.04562717497358e-08 8.27204564421866e-07 1.88510146602152 0.360655737704918 9.1 9 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0123846874193695 0.0428793435468682 1.88167400881057 0.36 9.1 9 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0123846874193695 0.0428793435468682 1.88167400881057 0.36 9.1 9 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000362024493961615 0.00218288497842109 1.87378439032499 0.358490566037736 9.1 9 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.24362207498988e-06 2.30221505256204e-05 1.87067006723858 0.357894736842105 9.1 9 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00909254883062142 0.0335199403781717 1.86674008810573 0.357142857142857 9.1 9 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.0602095868437429 0.140686768602046 1.86674008810573 0.357142857142857 9.1 9 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0602095868437429 0.140686768602046 1.86674008810573 0.357142857142857 9.1 9 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0602095868437429 0.140686768602046 1.86674008810573 0.357142857142857 9.1 9 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.24968755092224e-09 3.95178974436078e-08 1.86207323788546 0.35625 9.1 9 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 5.1676179071941e-06 5.00239474961715e-05 1.85844346549192 0.355555555555556 9.1 9 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 5.1676179071941e-06 5.00239474961715e-05 1.85844346549192 0.355555555555556 9.1 9 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 2.8487150566675e-09 7.64853118044879e-08 1.85469660366634 0.354838709677419 9.1 9 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00669454684693997 0.0269898340342166 1.85469660366634 0.354838709677419 9.1 9 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000114398727053342 0.000797987199004437 1.8495086411386 0.353846153846154 9.1 9 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0429375445286805 0.107193203270723 1.84477844001037 0.352941176470588 9.1 9 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0429375445286805 0.107193203270723 1.84477844001037 0.352941176470588 9.1 9 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.57980985605599e-08 4.26868537810195e-07 1.842566475454 0.352517985611511 9.1 9 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 9.53681395081989e-07 1.0280974433346e-05 1.83908467939305 0.351851851851852 9.1 9 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000475223639505608 0.00273782687860923 1.83908467939305 0.351851851851852 9.1 9 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0308941043933963 0.0867619882712569 1.82940528634361 0.35 9.1 9 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 7.53921760030765e-14 5.96017035846544e-12 1.82239607068712 0.348659003831418 9.1 9 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 6.25739808944809e-09 1.5352202553939e-07 1.81948084536887 0.348101265822785 9.1 9 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00149381873098797 0.00759180019355672 1.81804252058993 0.347826086956522 9.1 9 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.0223788168364472 0.068337030811726 1.81804252058993 0.347826086956522 9.1 9 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0223788168364472 0.068337030811726 1.81804252058993 0.347826086956522 9.1 9 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 5.05650055076971e-19 8.99425035468162e-17 1.81682725152536 0.347593582887701 9.1 9 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0011117276190632 0.00577368029900342 1.81340465701699 0.346938775510204 9.1 9 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0162963886908901 0.0530658148904729 1.80930193154863 0.346153846153846 9.1 9 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0162963886908901 0.0530658148904729 1.80930193154863 0.346153846153846 9.1 9 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0162963886908901 0.0530658148904729 1.80930193154863 0.346153846153846 9.1 9 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0119177637369234 0.0417822725586915 1.80236974024001 0.344827586206897 9.1 9 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0119177637369234 0.0417822725586915 1.80236974024001 0.344827586206897 9.1 9 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.37649763919237e-08 2.76078303398215e-07 1.79777771542411 0.343949044585987 9.1 9 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.00643767094615507 0.0266060395946853 1.7920704845815 0.342857142857143 9.1 9 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.00351281537947204 0.0158690040793292 1.78478564521328 0.341463414634146 9.1 9 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.00351281537947204 0.0158690040793292 1.78478564521328 0.341463414634146 9.1 9 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 5.74606939641153e-09 1.460117276981e-07 1.78328582534335 0.341176470588235 9.1 9 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00193137580586042 0.00944449406096009 1.77936076483269 0.340425531914894 9.1 9 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00143537044302768 0.00734723791521003 1.77713656387665 0.34 9.1 9 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00143537044302768 0.00734723791521003 1.77713656387665 0.34 9.1 9 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.90491078028215e-14 4.94275767078912e-12 1.76607628813279 0.337883959044369 9.1 9 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.23907236065425e-08 2.76078303398215e-07 1.76290957432943 0.337278106508876 9.1 9 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.29732355455869e-09 6.67161513905512e-08 1.76092487455535 0.336898395721925 9.1 9 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.24134957965569e-19 6.58920064550006e-17 1.75456040205994 0.335680751173709 9.1 9 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00183500771654048 0.00903534941396922 1.74229074889868 0.333333333333333 9.1 9 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00183500771654048 0.00903534941396922 1.74229074889868 0.333333333333333 9.1 9 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00333254309681357 0.0151788593189858 1.74229074889868 0.333333333333333 9.1 9 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00609505300795038 0.0256605338174952 1.74229074889868 0.333333333333333 9.1 9 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0112518250945432 0.0399285464078177 1.74229074889868 0.333333333333333 9.1 9 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0112518250945432 0.0399285464078177 1.74229074889868 0.333333333333333 9.1 9 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0112518250945432 0.0399285464078177 1.74229074889868 0.333333333333333 9.1 9 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0112518250945432 0.0399285464078177 1.74229074889868 0.333333333333333 9.1 9 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0153570867595969 0.0505859593956165 1.74229074889868 0.333333333333333 9.1 9 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0153570867595969 0.0505859593956165 1.74229074889868 0.333333333333333 9.1 9 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0210400326434034 0.0648189289535102 1.74229074889868 0.333333333333333 9.1 9 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0210400326434034 0.0648189289535102 1.74229074889868 0.333333333333333 9.1 9 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0210400326434034 0.0648189289535102 1.74229074889868 0.333333333333333 9.1 9 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0210400326434034 0.0648189289535102 1.74229074889868 0.333333333333333 9.1 9 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0210400326434034 0.0648189289535102 1.74229074889868 0.333333333333333 9.1 9 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0400928214755126 0.105262149372056 1.74229074889868 0.333333333333333 9.1 9 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0400928214755126 0.105262149372056 1.74229074889868 0.333333333333333 9.1 9 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0787732735895662 0.171660594667615 1.74229074889868 0.333333333333333 9.1 9 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0787732735895662 0.171660594667615 1.74229074889868 0.333333333333333 9.1 9 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0787732735895662 0.171660594667615 1.74229074889868 0.333333333333333 9.1 9 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0787732735895662 0.171660594667615 1.74229074889868 0.333333333333333 9.1 9 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0787732735895662 0.171660594667615 1.74229074889868 0.333333333333333 9.1 9 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0787732735895662 0.171660594667615 1.74229074889868 0.333333333333333 9.1 9 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0787732735895662 0.171660594667615 1.74229074889868 0.333333333333333 9.1 9 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.000235898817666654 0.00152583644336204 1.74229074889868 0.333333333333333 9.1 9 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00827019922562809 0.0311335806827216 1.74229074889868 0.333333333333333 9.1 9 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00827019922562809 0.0311335806827216 1.74229074889868 0.333333333333333 9.1 9 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0289600325947791 0.0825854236119654 1.74229074889868 0.333333333333333 9.1 9 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0289600325947791 0.0825854236119654 1.74229074889868 0.333333333333333 9.1 9 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0289600325947791 0.0825854236119654 1.74229074889868 0.333333333333333 9.1 9 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 9.98342048845332e-23 3.44363505269144e-20 1.73897840907187 0.332699619771863 9.1 9 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 5.85944439438819e-08 8.09513531380038e-07 1.73160184859869 0.331288343558282 9.1 9 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 9.29667665169166e-12 4.72470388405615e-10 1.72888851236869 0.330769230769231 9.1 9 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.14903986404052e-08 3.82260465816207e-07 1.70441486305306 0.326086956521739 9.1 9 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.000118175078469022 0.000816325906123389 1.70177235938941 0.325581395348837 9.1 9 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00570568302063041 0.0240925428437896 1.70177235938941 0.325581395348837 9.1 9 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00015760629786729 0.00105546424821945 1.70030783928666 0.325301204819277 9.1 9 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.00772588770924661 0.0299006125871714 1.69873348017621 0.325 9.1 9 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.13038470881694e-05 0.000102454614053918 1.69644099234871 0.324561403508772 9.1 9 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0142700428987207 0.047852523896889 1.69104690334284 0.323529411764706 9.1 9 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0142700428987207 0.047852523896889 1.69104690334284 0.323529411764706 9.1 9 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 6.0251153478103e-06 5.71582609328937e-05 1.68608782151485 0.32258064516129 9.1 9 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.019482105765624 0.0616067477877399 1.68608782151485 0.32258064516129 9.1 9 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.026699367081037 0.0779188444073556 1.68006607929515 0.321428571428571 9.1 9 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.026699367081037 0.0779188444073556 1.68006607929515 0.321428571428571 9.1 9 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000262877417358229 0.00166751452430413 1.67776146190243 0.320987654320988 9.1 9 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0367601950302659 0.0977752477160156 1.67259911894273 0.32 9.1 9 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0367601950302659 0.0977752477160156 1.67259911894273 0.32 9.1 9 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.000468586310983363 0.00272162579807888 1.67259911894273 0.32 9.1 9 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 3.09323837823692e-05 0.000241850451221491 1.66309571485783 0.318181818181818 9.1 9 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000183884431333991 0.00122274554106668 1.66309571485783 0.318181818181818 9.1 9 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0071538007823617 0.0282773847591686 1.66309571485783 0.318181818181818 9.1 9 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0509042375693 0.123612167339785 1.66309571485783 0.318181818181818 9.1 9 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 7.00668214873929e-06 6.47435629717923e-05 1.66125396988013 0.317829457364341 9.1 9 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00968195700521335 0.0352363806097662 1.65730095626947 0.317073170731707 9.1 9 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0131328566061958 0.0448410631551253 1.65059123579875 0.315789473684211 9.1 9 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0710101118844753 0.158251493520975 1.65059123579875 0.315789473684211 9.1 9 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0710101118844753 0.158251493520975 1.65059123579875 0.315789473684211 9.1 9 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.24260226885118e-08 3.89173540070149e-07 1.64273127753304 0.314285714285714 9.1 9 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0178598800436465 0.056729038620779 1.64273127753304 0.314285714285714 9.1 9 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 2.01858926151818e-05 0.00017303930838195 1.64149706921033 0.31404958677686 9.1 9 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0243620352365949 0.0725254730997374 1.63339757709251 0.3125 9.1 9 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.100024023869323 0.201321338000067 1.63339757709251 0.3125 9.1 9 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 6.2551525928969e-05 0.000463598028108974 1.63040051731803 0.311926605504587 9.1 9 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 1.1960191424907e-06 1.27965055621373e-05 1.62542978403352 0.310975609756098 9.1 9 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.80154961903263e-07 5.5358595471434e-06 1.62416934219368 0.310734463276836 9.1 9 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.30869283181836e-05 0.000117865183523894 1.62349819783741 0.310606060606061 9.1 9 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.0033387090420538 0.0151788593189858 1.62213276621601 0.310344827586207 9.1 9 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.0033387090420538 0.0151788593189858 1.62213276621601 0.310344827586207 9.1 9 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0333510885858881 0.0893758927640655 1.62213276621601 0.310344827586207 9.1 9 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0333510885858881 0.0893758927640655 1.62213276621601 0.310344827586207 9.1 9 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0333510885858881 0.0893758927640655 1.62213276621601 0.310344827586207 9.1 9 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.73219685129098e-15 2.99070470722082e-13 1.61728334090595 0.309417040358744 9.1 9 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.24824414029285e-16 1.48020950969727e-14 1.61480605995487 0.308943089430894 9.1 9 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0458552200699886 0.112697717028659 1.60826838359878 0.307692307692308 9.1 9 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0458552200699886 0.112697717028659 1.60826838359878 0.307692307692308 9.1 9 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00810238353093076 0.030969919627248 1.60006293266205 0.306122448979592 9.1 9 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 2.58087997899714e-05 0.000213564318179227 1.59599152570871 0.305343511450382 9.1 9 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 2.58087997899714e-05 0.000213564318179227 1.59599152570871 0.305343511450382 9.1 9 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.46377626342066e-17 5.47661513649733e-15 1.595468494778 0.305243445692884 9.1 9 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.17765115130012e-24 1.03293252943336e-21 1.59282406493426 0.304737516005122 9.1 9 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0109170907704641 0.0391310331646609 1.59078720551618 0.304347826086957 9.1 9 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0633841091399233 0.145476753719534 1.59078720551618 0.304347826086957 9.1 9 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.000113954725711985 0.000797987199004437 1.58672907488987 0.303571428571429 9.1 9 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0300621266027043 0.0850465331126208 1.58390068081698 0.303030303030303 9.1 9 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0147330386572851 0.0487560790914342 1.58021719086159 0.302325581395349 9.1 9 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.41170697415977e-26 2.00885902422935e-23 1.57870462654733 0.302036199095023 9.1 9 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000508743018994395 0.00285016266153159 1.57368196674719 0.301075268817204 9.1 9 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.000350452902334165 0.00214031965674471 1.56806167400881 0.3 9.1 9 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0882026865235091 0.184306054218728 1.56806167400881 0.3 9.1 9 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0882026865235091 0.184306054218728 1.56806167400881 0.3 9.1 9 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0882026865235091 0.184306054218728 1.56806167400881 0.3 9.1 9 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0882026865235091 0.184306054218728 1.56806167400881 0.3 9.1 9 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0882026865235091 0.184306054218728 1.56806167400881 0.3 9.1 9 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0882026865235091 0.184306054218728 1.56806167400881 0.3 9.1 9 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0269843234211078 0.0779188444073556 1.55393499226098 0.297297297297297 9.1 9 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0563037200390771 0.132818516037647 1.54870288790994 0.296296296296296 9.1 9 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0563037200390771 0.132818516037647 1.54870288790994 0.296296296296296 9.1 9 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.000559394425335846 0.00309734734339653 1.54672750157332 0.295918367346939 9.1 9 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0366421614793641 0.0977752477160156 1.5373153666753 0.294117647058824 9.1 9 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.123810056927925 0.227624949623303 1.5373153666753 0.294117647058824 9.1 9 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0241544179463095 0.0720581482968522 1.52981626732567 0.292682926829268 9.1 9 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0241544179463095 0.0720581482968522 1.52981626732567 0.292682926829268 9.1 9 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.00544384366777722 0.0230553260096636 1.52785496441884 0.292307692307692 9.1 9 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.49837360675346e-06 3.45707336278484e-05 1.52450440528634 0.291666666666667 9.1 9 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00369221766795129 0.0165742136955668 1.52450440528634 0.291666666666667 9.1 9 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.077558728893806 0.1708453114797 1.52450440528634 0.291666666666667 9.1 9 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.077558728893806 0.1708453114797 1.52450440528634 0.291666666666667 9.1 9 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.12376615301932e-07 8.89239941211268e-06 1.5205446535843 0.290909090909091 9.1 9 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0498912709723928 0.121359450587547 1.51747903936337 0.290322580645161 9.1 9 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0498912709723928 0.121359450587547 1.51747903936337 0.290322580645161 9.1 9 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.00490443968459631 0.0212128196692418 1.51503543382494 0.289855072463768 9.1 9 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00490443968459631 0.0212128196692418 1.51503543382494 0.289855072463768 9.1 9 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.00226680276709811 0.0108608092174431 1.51138474603259 0.289156626506024 9.1 9 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0143927478762252 0.047852523896889 1.50775160962386 0.288461538461538 9.1 9 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0143927478762252 0.047852523896889 1.50775160962386 0.288461538461538 9.1 9 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0143927478762252 0.047852523896889 1.50775160962386 0.288461538461538 9.1 9 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0143927478762252 0.047852523896889 1.50775160962386 0.288461538461538 9.1 9 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 4.94357438348489e-25 3.5173531738495e-22 1.50684605310156 0.288288288288288 9.1 9 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.00965991495977086 0.0352363806097662 1.50604793548869 0.288135593220339 9.1 9 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.00965991495977086 0.0352363806097662 1.50604793548869 0.288135593220339 9.1 9 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00651587787615285 0.0266060395946853 1.50470564677613 0.287878787878788 9.1 9 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 7.21697415092684e-07 8.02324548185069e-06 1.50300618252633 0.28755364806867 9.1 9 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00204335035643016 0.00985656799050889 1.50197478353334 0.28735632183908 9.1 9 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00204335035643016 0.00985656799050889 1.50197478353334 0.28735632183908 9.1 9 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00865832076768307 0.0325086819324881 1.49339207048458 0.285714285714286 9.1 9 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0441550740536511 0.109535216179567 1.49339207048458 0.285714285714286 9.1 9 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0441550740536511 0.109535216179567 1.49339207048458 0.285714285714286 9.1 9 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0681454612222931 0.155048298435672 1.49339207048458 0.285714285714286 9.1 9 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.107446632542708 0.208590120202282 1.49339207048458 0.285714285714286 9.1 9 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.0192562643371098 0.0610282052376555 1.49339207048458 0.285714285714286 9.1 9 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.00775356714312455 0.0299006125871714 1.48224735354067 0.283582089552239 9.1 9 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.00775356714312455 0.0299006125871714 1.48224735354067 0.283582089552239 9.1 9 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00421219107637422 0.0184998392027176 1.46607392285377 0.280487804878049 9.1 9 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.0017563096787551 0.00870811384274743 1.46352422907489 0.28 9.1 9 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0934248253962938 0.192671777592647 1.46352422907489 0.28 9.1 9 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0934248253962938 0.192671777592647 1.46352422907489 0.28 9.1 9 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0934248253962938 0.192671777592647 1.46352422907489 0.28 9.1 9 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.94525209433388e-08 5.69878392654181e-07 1.45903489094889 0.279141104294479 9.1 9 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0345430155124423 0.0923960734477544 1.45866202233378 0.27906976744186 9.1 9 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.61354266719477e-05 0.00027351442635203 1.45666931465299 0.278688524590164 9.1 9 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0136219473334153 0.0461524548939285 1.45666931465299 0.278688524590164 9.1 9 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 5.01464300035605e-07 5.70866959160533e-06 1.45295726713211 0.277978339350181 9.1 9 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.149921697058191 0.267677007420083 1.45190895741557 0.277777777777778 9.1 9 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.149921697058191 0.267677007420083 1.45190895741557 0.277777777777778 9.1 9 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.000157985864280213 0.00105546424821945 1.45003552650277 0.27741935483871 9.1 9 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.05446662266473e-12 6.2521083502163e-11 1.44631491239575 0.276707530647986 9.1 9 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.000699273567022144 0.00377164911931318 1.44047660342017 0.275590551181102 9.1 9 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.0107971889498731 0.0387989895850237 1.43928366213369 0.27536231884058 9.1 9 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.0239203020601272 0.0716601891190757 1.42551061273528 0.272727272727273 9.1 9 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0239203020601272 0.0716601891190757 1.42551061273528 0.272727272727273 9.1 9 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0710630389036564 0.158251493520975 1.42551061273528 0.272727272727273 9.1 9 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0710630389036564 0.158251493520975 1.42551061273528 0.272727272727273 9.1 9 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0710630389036564 0.158251493520975 1.42551061273528 0.272727272727273 9.1 9 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.128650030657736 0.235360958837754 1.42551061273528 0.272727272727273 9.1 9 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.128650030657736 0.235360958837754 1.42551061273528 0.272727272727273 9.1 9 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.128650030657736 0.235360958837754 1.42551061273528 0.272727272727273 9.1 9 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.00990623814262e-05 0.000237949809826497 1.41872246696035 0.271428571428571 9.1 9 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.012640481724816 0.043447839358486 1.41872246696035 0.271428571428571 9.1 9 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.012640481724816 0.043447839358486 1.41872246696035 0.271428571428571 9.1 9 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.012640481724816 0.043447839358486 1.41872246696035 0.271428571428571 9.1 9 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0211757130947595 0.0650821592523603 1.41745688045994 0.271186440677966 9.1 9 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00251607091395942 0.0120146607737055 1.41662892667463 0.271028037383178 9.1 9 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0067792400648038 0.0269898340342166 1.41433013734128 0.270588235294118 9.1 9 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0067792400648038 0.0269898340342166 1.41433013734128 0.270588235294118 9.1 9 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.11095046946388 0.214514290824866 1.40723483564893 0.269230769230769 9.1 9 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0544430400828821 0.131087049133572 1.40233157838186 0.268292682926829 9.1 9 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0544430400828821 0.131087049133572 1.40233157838186 0.268292682926829 9.1 9 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0544430400828821 0.131087049133572 1.40233157838186 0.268292682926829 9.1 9 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0544430400828821 0.131087049133572 1.40233157838186 0.268292682926829 9.1 9 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0544430400828821 0.131087049133572 1.40233157838186 0.268292682926829 9.1 9 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0960686991100862 0.196481800167367 1.39383259911894 0.266666666666667 9.1 9 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0960686991100862 0.196481800167367 1.39383259911894 0.266666666666667 9.1 9 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.34447086297849e-05 0.000118831182485614 1.38968428781204 0.265873015873016 9.1 9 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.34447086297849e-05 0.000118831182485614 1.38968428781204 0.265873015873016 9.1 9 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.34447086297849e-05 0.000118831182485614 1.38968428781204 0.265873015873016 9.1 9 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0115776293696308 0.0409825039626482 1.3894217364635 0.265822784810127 9.1 9 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.021818561461428 0.0669133899991639 1.38838794052863 0.265625 9.1 9 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0834545547764017 0.180479987001246 1.38358383000777 0.264705882352941 9.1 9 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0834545547764017 0.180479987001246 1.38358383000777 0.264705882352941 9.1 9 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.0170673338996821 0.0543329220117396 1.37931350954479 0.263888888888889 9.1 9 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.0170673338996821 0.0543329220117396 1.37931350954479 0.263888888888889 9.1 9 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0170673338996821 0.0543329220117396 1.37931350954479 0.263888888888889 9.1 9 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.00169250916893396 0.00848042446265149 1.37549269649896 0.263157894736842 9.1 9 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.0286274551904065 0.0821307837418315 1.37098288437929 0.262295081967213 9.1 9 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0286274551904065 0.0821307837418315 1.37098288437929 0.262295081967213 9.1 9 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.0286274551904065 0.0821307837418315 1.37098288437929 0.262295081967213 9.1 9 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.055519031756033 0.132818516037647 1.36353189044244 0.260869565217391 9.1 9 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.019690793208896 0.0621286003021263 1.36041880393458 0.26027397260274 9.1 9 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 6.36459853016058e-11 2.51578436344959e-09 1.35752358506724 0.259720062208398 9.1 9 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.042695448651951 0.106964125760082 1.35511502692119 0.259259259259259 9.1 9 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.130076831762561 0.236096086222097 1.35511502692119 0.259259259259259 9.1 9 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.130076831762561 0.236096086222097 1.35511502692119 0.259259259259259 9.1 9 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.0375192103477495 0.0992376139867054 1.35177730518001 0.258620689655172 9.1 9 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.0375192103477495 0.0992376139867054 1.35177730518001 0.258620689655172 9.1 9 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.0375192103477495 0.0992376139867054 1.35177730518001 0.258620689655172 9.1 9 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.112130413244936 0.214939226505626 1.34887025721188 0.258064516129032 9.1 9 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.112130413244936 0.214939226505626 1.34887025721188 0.258064516129032 9.1 9 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0970582211804307 0.198154732768655 1.34405286343612 0.257142857142857 9.1 9 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0842924623909327 0.182015438516384 1.34022365299898 0.256410256410256 9.1 9 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.00754519097562615 0.0295457837570994 1.33047657188626 0.254545454545455 9.1 9 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0491064743174518 0.120066173460024 1.33047657188626 0.254545454545455 9.1 9 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0491064743174518 0.120066173460024 1.33047657188626 0.254545454545455 9.1 9 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0430908571385414 0.10738754764999 1.3288658254312 0.254237288135593 9.1 9 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.0378628332652231 0.0999606896779452 1.32745961820852 0.253968253968254 9.1 9 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.0333087891608743 0.0893758927640655 1.32622131632586 0.253731343283582 9.1 9 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.00675062586847194 0.0269898340342166 1.31769888572169 0.252100840336134 9.1 9 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0139907169473815 0.0471772280002935 1.30671806167401 0.25 9.1 9 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.0139907169473815 0.0471772280002935 1.30671806167401 0.25 9.1 9 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.0492239480923562 0.120146960781171 1.30671806167401 0.25 9.1 9 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.129546893689085 0.235735587876686 1.30671806167401 0.25 9.1 9 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.129546893689085 0.235735587876686 1.30671806167401 0.25 9.1 9 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.129546893689085 0.235735587876686 1.30671806167401 0.25 9.1 9 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0294415947201038 0.0837907785734154 1.30671806167401 0.25 9.1 9 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.111862381190629 0.214939226505626 1.30671806167401 0.25 9.1 9 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.176393839410957 0.302419799375652 1.30671806167401 0.25 9.1 9 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.176393839410957 0.302419799375652 1.30671806167401 0.25 9.1 9 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0559401957777745 0.132818516037647 1.28529645410558 0.245901639344262 9.1 9 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0730296985783914 0.162123652226289 1.28206300390657 0.245283018867925 9.1 9 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0961007258724439 0.196481800167367 1.2776798825257 0.244444444444444 9.1 9 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0961007258724439 0.196481800167367 1.2776798825257 0.244444444444444 9.1 9 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.148261727220423 0.265379167087625 1.26712054465358 0.242424242424242 9.1 9 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00472450596697016 0.0206540220958767 1.26613675541084 0.242236024844721 9.1 9 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.0722430583817873 0.160627925120755 1.26165881816801 0.241379310344828 9.1 9 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.63490172214e-17 6.59546515060523e-15 1.25863353648652 0.240800516462234 9.1 9 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0826478753843359 0.179280376024253 1.25832109642682 0.240740740740741 9.1 9 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.0826478753843359 0.179280376024253 1.25832109642682 0.240740740740741 9.1 9 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0052775361482396 0.0225523541710059 1.25832109642682 0.240740740740741 9.1 9 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.0424191615771917 0.106691670269857 1.25709585680031 0.240506329113924 9.1 9 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.108854972594745 0.210749151023567 1.24990423290557 0.239130434782609 9.1 9 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.108854972594745 0.210749151023567 1.24990423290557 0.239130434782609 9.1 9 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.0418911576249457 0.106691670269857 1.24449339207048 0.238095238095238 9.1 9 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.0418911576249457 0.106691670269857 1.24449339207048 0.238095238095238 9.1 9 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.239516962561776 0.394026170780818 1.24449339207048 0.238095238095238 9.1 9 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.144956163473777 0.259789194739528 1.23794342684906 0.236842105263158 9.1 9 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.093029737619324 0.192671777592647 1.23544253103724 0.236363636363636 9.1 9 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.093029737619324 0.192671777592647 1.23544253103724 0.236363636363636 9.1 9 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.093029737619324 0.192671777592647 1.23544253103724 0.236363636363636 9.1 9 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0797610812764836 0.173547429138282 1.22504818281938 0.234375 9.1 9 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.0910787533222069 0.190036753632698 1.21960352422908 0.233333333333333 9.1 9 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.104177946067765 0.206202266331408 1.21338105726872 0.232142857142857 9.1 9 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.230087814043205 0.379831739423992 1.20620128769909 0.230769230769231 9.1 9 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.230087814043205 0.379831739423992 1.20620128769909 0.230769230769231 9.1 9 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.0762504090177983 0.168484987627837 1.20076794856531 0.22972972972973 9.1 9 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.0762504090177983 0.168484987627837 1.20076794856531 0.22972972972973 9.1 9 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.137126675583946 0.247628501720755 1.19782488986784 0.229166666666667 9.1 9 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.137126675583946 0.247628501720755 1.19782488986784 0.229166666666667 9.1 9 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.137126675583946 0.247628501720755 1.19782488986784 0.229166666666667 9.1 9 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.137126675583946 0.247628501720755 1.19782488986784 0.229166666666667 9.1 9 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.0743753276124258 0.164853724598882 1.19093291696872 0.227848101265823 9.1 9 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0421987142543717 0.106691670269857 1.18792551061274 0.227272727272727 9.1 9 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.0960396566527626 0.196481800167367 1.1778867034808 0.225352112676056 9.1 9 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.152598369431261 0.272114636216397 1.17337948395217 0.224489795918367 9.1 9 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.128756431630291 0.235360958837754 1.17154033115601 0.224137931034483 9.1 9 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0932485743151806 0.192671777592647 1.16916879202411 0.223684210526316 9.1 9 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.0932485743151806 0.192671777592647 1.16916879202411 0.223684210526316 9.1 9 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0128988107764725 0.044228934301013 1.16742324291688 0.223350253807107 9.1 9 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.258662380409103 0.407164344382914 1.16152716593245 0.222222222222222 9.1 9 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.258662380409103 0.407164344382914 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.105926814257385 0.206202266331408 1.16152716593245 0.222222222222222 9.1 9 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0468936580052877 0.115051164381939 1.15238128273613 0.220472440944882 9.1 9 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0297546566098084 0.084344375210672 1.15056936248026 0.220125786163522 9.1 9 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0297546566098084 0.084344375210672 1.15056936248026 0.220125786163522 9.1 9 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.039480578339157 0.10403863514189 1.14917049395445 0.219858156028369 9.1 9 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0333065704478078 0.0893758927640655 1.1465397186301 0.219354838709677 9.1 9 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.162488654458957 0.283707184411161 1.14040849018823 0.218181818181818 9.1 9 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.162488654458957 0.283707184411161 1.14040849018823 0.218181818181818 9.1 9 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.162488654458957 0.283707184411161 1.14040849018823 0.218181818181818 9.1 9 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.305580389801233 0.465070475601235 1.1362765753687 0.217391304347826 9.1 9 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.305580389801233 0.465070475601235 1.1362765753687 0.217391304347826 9.1 9 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.223581214755372 0.369948916973133 1.12004405286344 0.214285714285714 9.1 9 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.144630964849674 0.259533244616754 1.12004405286344 0.214285714285714 9.1 9 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.288101041809045 0.44952607729635 1.12004405286344 0.214285714285714 9.1 9 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.288101041809045 0.44952607729635 1.12004405286344 0.214285714285714 9.1 9 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.213428187434668 0.353972390116005 1.11210047802043 0.212765957446809 9.1 9 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.106224832565686 0.206499913580563 1.10873047657189 0.212121212121212 9.1 9 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.10243771791026 0.205308271248311 1.10568451372416 0.211538461538462 9.1 9 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.186618877922228 0.314270607435895 1.09595708398465 0.209677419354839 9.1 9 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.339576850430253 0.504929841339864 1.08893171806167 0.208333333333333 9.1 9 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.339576850430253 0.504929841339864 1.08893171806167 0.208333333333333 9.1 9 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.339576850430253 0.504929841339864 1.08893171806167 0.208333333333333 9.1 9 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00295076621797923 0.0138578888718958 1.08761180082766 0.208080808080808 9.1 9 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.222509619680886 0.368604410716997 1.0848225417671 0.207547169811321 9.1 9 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0856992530827128 0.183108163868919 1.08270925110132 0.207142857142857 9.1 9 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.318185564801716 0.476107317258509 1.08142184414401 0.206896551724138 9.1 9 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0954586387010073 0.196481800167367 1.07612075667271 0.205882352941176 9.1 9 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.128844825674357 0.235360958837754 1.07468401333937 0.205607476635514 9.1 9 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.102370551163865 0.205308271248311 1.06826586063861 0.204379562043796 9.1 9 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.102370551163865 0.205308271248311 1.06826586063861 0.204379562043796 9.1 9 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0986106636558688 0.201035779917337 1.06745982502947 0.204225352112676 9.1 9 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.254253471947588 0.401111630356339 1.0667086217747 0.204081632653061 9.1 9 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 1.3478611081109e-07 1.72793365481244e-06 1.05812291823359 0.202439024390244 9.1 9 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.275587539477158 0.431895450083696 1.04537444933921 0.2 9.1 9 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.275587539477158 0.431895450083696 1.04537444933921 0.2 9.1 9 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.308003112633343 0.467757128364192 1.04537444933921 0.2 9.1 9 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.308003112633343 0.467757128364192 1.04537444933921 0.2 9.1 9 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.34870119278102 0.513666456860653 1.04537444933921 0.2 9.1 9 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.34870119278102 0.513666456860653 1.04537444933921 0.2 9.1 9 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.34870119278102 0.513666456860653 1.04537444933921 0.2 9.1 9 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.373822417868129 0.547497448277641 1.04537444933921 0.2 9.1 9 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.267656085945616 0.420855922984101 1.02823716328447 0.19672131147541 9.1 9 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.314544487637181 0.471651007278934 1.02264891783183 0.195652173913043 9.1 9 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.379440461581414 0.551525819029982 1.01165269290891 0.193548387096774 9.1 9 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.244005511238961 0.400946700338385 1.00089043021839 0.191489361702128 9.1 9 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.359448116076537 0.528403583860446 0.995594713656388 0.19047619047619 9.1 9 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.232163943503019 0.382371865283328 0.985393948147613 0.188524590163934 9.1 9 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.385517256251272 0.559786791475061 0.972441348222518 0.186046511627907 9.1 9 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.316019933396278 0.473364594971478 0.96793930494371 0.185185185185185 9.1 9 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.441995524901814 0.611233850277241 0.96793930494371 0.185185185185185 9.1 9 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.231721668396533 0.38208567106404 0.952815253303965 0.182291666666667 9.1 9 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.440814750220893 0.611233850277241 0.950340408490188 0.181818181818182 9.1 9 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.269609828215958 0.423460028202327 0.942052556090564 0.180232558139535 9.1 9 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.475450847313285 0.655587747797292 0.933370044052863 0.178571428571429 9.1 9 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.303396670660238 0.462736829956612 0.929934326099295 0.177914110429448 9.1 9 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.471096378225484 0.650844802150354 0.922389220005183 0.176470588235294 9.1 9 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.352405139046828 0.518585845774184 0.904107631860936 0.172972972972973 9.1 9 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.325771700729098 0.485925712932397 0.901891681782845 0.172549019607843 9.1 9 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.500898028206801 0.663477504562003 0.896035242290749 0.171428571428571 9.1 9 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.472728039155461 0.652465567136975 0.883415027610598 0.169014084507042 9.1 9 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.389802966050874 0.565432844740462 0.881641101852343 0.168674698795181 9.1 9 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.521784930522477 0.685595527362405 0.871145374449339 0.166666666666667 9.1 9 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.50894126168601 0.669956905993702 0.86011821781074 0.164556962025316 9.1 9 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.571016452168058 0.742060649712463 0.843043910757425 0.161290322580645 9.1 9 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.612835574014127 0.777241552426117 0.80413419179939 0.153846153846154 9.1 9 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.612835574014127 0.777241552426117 0.80413419179939 0.153846153846154 9.1 9 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.722209158505655 0.880637217269534 0.764908133662834 0.146341463414634 9.1 9 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.807908631801452 0.951700317097241 0.730638055989768 0.139784946236559 9.1 9 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.855357877409965 0.995236516397694 0.728028634361234 0.139285714285714 9.1 9 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.891392924350777 1 0.727451292065943 0.139175257731959 9.1 9 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.730442926421752 0.889914626967597 0.706334087391356 0.135135135135135 9.1 9 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.800671475279364 0.944739228293976 0.700508651619056 0.134020618556701 9.1 9 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.916786244910695 1 0.67443512860594 0.129032258064516 9.1 9 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.804636247638264 0.948630803967895 0.653359030837004 0.125 9.1 9 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.902216050190911 1 0.629160548213412 0.12037037037037 9.1 9 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.949579094811285 1 0.623660893071686 0.119318181818182 9.1 9 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.883841093082876 1 0.606014173529975 0.115942028985507 9.1 9 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.873727377774392 1 0.591721386418419 0.113207547169811 9.1 9 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.953015708492901 1 0.550197078599583 0.105263157894737 9.1 9 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.903013647229655 1 0.544465859030837 0.104166666666667 9.1 9 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999699748 1 0.522248360501115 0.0999160369437447 9.1 9 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999999999999 1 0.425333184631685 0.081374321880651 9.1 9 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.997769634270845 1 0.348458149779736 0.0666666666666667 9.1 9 1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.000151236606762323 0.00110363944319378 4.80691543991784 1 9.2 9 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.000155312105447466 0.00111620770733204 4.12021323421529 0.857142857142857 9.2 9 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 2.48867441409384e-05 0.000242560526798324 3.84553235193427 0.8 9.2 9 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 1.76209558226571e-05 0.000177834185359156 3.60518657993838 0.75 9.2 9 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00052995354203928 0.00315533008502885 3.60518657993838 0.75 9.2 9 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 1.15782013774082e-05 0.000122042818963348 3.43351102851274 0.714285714285714 9.2 9 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.00233223751317138 0.0114782607868801 3.43351102851274 0.714285714285714 9.2 9 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.000329882432657926 0.00208632311854324 3.36484080794248 0.7 9.2 9 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.000329882432657926 0.00208632311854324 3.36484080794248 0.7 9.2 9 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 4.84533994226819e-05 0.000400867368479513 3.32786453532773 0.692307692307692 9.2 9 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 4.84533994226819e-05 0.000400867368479513 3.32786453532773 0.692307692307692 9.2 9 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 1.62544080681489e-10 7.00909778211389e-09 3.30475436494351 0.6875 9.2 9 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.000196844443543611 0.00134023752709358 3.20461029327856 0.666666666666667 9.2 9 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000196844443543611 0.00134023752709358 3.20461029327856 0.666666666666667 9.2 9 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000196844443543611 0.00134023752709358 3.20461029327856 0.666666666666667 9.2 9 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.00135708972472577 0.00725991984317582 3.20461029327856 0.666666666666667 9.2 9 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 1.53337765591457e-10 6.8187387636451e-09 3.11799920427103 0.648648648648649 9.2 9 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.000114828755904175 0.000883250376495355 3.09015992566147 0.642857142857143 9.2 9 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.46783504817189e-07 4.44522692854253e-06 3.07642588154742 0.64 9.2 9 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.57957555721351e-06 2.24773601791482e-05 3.05894618903862 0.636363636363636 9.2 9 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.000771792982615753 0.00435818021532625 3.05894618903862 0.636363636363636 9.2 9 2 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.000771792982615753 0.00435818021532625 3.05894618903862 0.636363636363636 9.2 9 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 3.49548597756418e-16 4.14506378839485e-14 3.05200980312244 0.634920634920635 9.2 9 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 1.34010277799194e-14 1.27131083538835e-12 3.03594659363232 0.631578947368421 9.2 9 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00533604413172489 0.0225987821412039 3.00432214994865 0.625 9.2 9 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00533604413172489 0.0225987821412039 3.00432214994865 0.625 9.2 9 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.00533604413172489 0.0225987821412039 3.00432214994865 0.625 9.2 9 2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%REACT_205099.1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION 0.00533604413172489 0.0225987821412039 3.00432214994865 0.625 9.2 9 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00533604413172489 0.0225987821412039 3.00432214994865 0.625 9.2 9 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 3.77425563753351e-05 0.000353310368608616 2.93755943550534 0.611111111111111 9.2 9 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 3.77425563753351e-05 0.000353310368608616 2.93755943550534 0.611111111111111 9.2 9 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000243063752340979 0.00160874288177309 2.8841492639507 0.6 9.2 9 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 1.21311910949705e-05 0.000126931506824581 2.84045003267872 0.590909090909091 9.2 9 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 5.89762528956773e-08 1.25258519209774e-06 2.82759731759873 0.588235294117647 9.2 9 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00157672093731676 0.00812925323841214 2.80403400661874 0.583333333333333 9.2 9 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00157672093731676 0.00812925323841214 2.80403400661874 0.583333333333333 9.2 9 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 7.56469981830839e-05 0.00059534465389111 2.78295104416296 0.578947368421053 9.2 9 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 4.21545930822534e-05 0.000357059440214563 2.74680882281019 0.571428571428571 9.2 9 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 4.21545930822534e-05 0.000357059440214563 2.74680882281019 0.571428571428571 9.2 9 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000860191925114325 0.00480020827230465 2.74680882281019 0.571428571428571 9.2 9 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 1.22286957957018e-06 1.79396228013234e-05 2.72391874928677 0.566666666666667 9.2 9 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 1.09997564918479e-10 5.39746671996536e-09 2.72089553202896 0.566037735849057 9.2 9 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 2.34898175444098e-05 0.000232125071983994 2.71695220517095 0.565217391304348 9.2 9 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.34898175444098e-05 0.000232125071983994 2.71695220517095 0.565217391304348 9.2 9 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000470583990960291 0.00283746194549362 2.70388993495378 0.5625 9.2 9 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000470583990960291 0.00283746194549362 2.70388993495378 0.5625 9.2 9 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000470583990960291 0.00283746194549362 2.70388993495378 0.5625 9.2 9 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.000470583990960291 0.00283746194549362 2.70388993495378 0.5625 9.2 9 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000470583990960291 0.00283746194549362 2.70388993495378 0.5625 9.2 9 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 6.64349696925853e-09 2.05515134505541e-07 2.67050857773213 0.555555555555556 9.2 9 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0103097371404738 0.0374253978339139 2.67050857773213 0.555555555555556 9.2 9 2 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0103097371404738 0.0374253978339139 2.67050857773213 0.555555555555556 9.2 9 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0103097371404738 0.0374253978339139 2.67050857773213 0.555555555555556 9.2 9 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0103097371404738 0.0374253978339139 2.67050857773213 0.555555555555556 9.2 9 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.74932798838435e-09 1.30129115304169e-07 2.65914471144391 0.553191489361702 9.2 9 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000141905520154292 0.00104627748797698 2.64380349195481 0.55 9.2 9 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000141905520154292 0.00104627748797698 2.64380349195481 0.55 9.2 9 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000141905520154292 0.00104627748797698 2.64380349195481 0.55 9.2 9 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.19588793846588e-11 7.0906189018206e-10 2.62878188120507 0.546875 9.2 9 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.00544922987908166 0.022607154862779 2.62195387631882 0.545454545454545 9.2 9 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00544922987908166 0.022607154862779 2.62195387631882 0.545454545454545 9.2 9 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00544922987908166 0.022607154862779 2.62195387631882 0.545454545454545 9.2 9 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.00544922987908166 0.022607154862779 2.62195387631882 0.545454545454545 9.2 9 2 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.00544922987908166 0.022607154862779 2.62195387631882 0.545454545454545 9.2 9 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00544922987908166 0.022607154862779 2.62195387631882 0.545454545454545 9.2 9 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00544922987908166 0.022607154862779 2.62195387631882 0.545454545454545 9.2 9 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 4.31560792498546e-05 0.00036337929451209 2.60374586328883 0.541666666666667 9.2 9 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.38619545565345e-05 0.000234176285061714 2.58833908303268 0.538461538461538 9.2 9 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00290958023102636 0.0135961023804035 2.58833908303268 0.538461538461538 9.2 9 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00290958023102636 0.0135961023804035 2.58833908303268 0.538461538461538 9.2 9 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.00290958023102636 0.0135961023804035 2.58833908303268 0.538461538461538 9.2 9 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 1.23858011528588e-07 2.51785643435973e-06 2.57932047995591 0.536585365853659 9.2 9 2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.00156548126542672 0.00812925323841214 2.56368823462285 0.533333333333333 9.2 9 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000847346448152526 0.00474714171543718 2.54483758583885 0.529411764705882 9.2 9 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.2578556519212e-06 1.8264577476366e-05 2.53698314884553 0.527777777777778 9.2 9 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000251631539933535 0.00165009991394203 2.51790808757601 0.523809523809524 9.2 9 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000251631539933535 0.00165009991394203 2.51790808757601 0.523809523809524 9.2 9 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000137847611382538 0.00103240605788079 2.50795588169626 0.521739130434783 9.2 9 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.000137847611382538 0.00103240605788079 2.50795588169626 0.521739130434783 9.2 9 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.18857689001361e-11 7.0906189018206e-10 2.50222995502572 0.520547945205479 9.2 9 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 7.57254970866415e-05 0.00059534465389111 2.49959602875728 0.52 9.2 9 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 2.16756601980156e-06 2.88266023007255e-05 2.46841603671456 0.513513513513513 9.2 9 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.86908099419212e-05 0.000353310368608616 2.40345771995892 0.5 9.2 9 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.000232539143515221 0.00154627664122504 2.40345771995892 0.5 9.2 9 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00143658202649804 0.0075713193470619 2.40345771995892 0.5 9.2 9 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.00143658202649804 0.0075713193470619 2.40345771995892 0.5 9.2 9 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00143658202649804 0.0075713193470619 2.40345771995892 0.5 9.2 9 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00266037853989316 0.0126612664289898 2.40345771995892 0.5 9.2 9 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.88731136937082e-08 4.71165627827137e-07 2.40345771995892 0.5 9.2 9 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 7.01833830882147e-05 0.000561072776036683 2.40345771995892 0.5 9.2 9 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000779791489735127 0.00438594185728492 2.40345771995892 0.5 9.2 9 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0049589685369384 0.0215140616709248 2.40345771995892 0.5 9.2 9 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0177215736181201 0.0579068412576695 2.40345771995892 0.5 9.2 9 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0177215736181201 0.0579068412576695 2.40345771995892 0.5 9.2 9 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.0177215736181201 0.0579068412576695 2.40345771995892 0.5 9.2 9 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0177215736181201 0.0579068412576695 2.40345771995892 0.5 9.2 9 2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%REACT_224974.1 ADENYLATE CYCLASE ACTIVATING PATHWAY 0.0177215736181201 0.0579068412576695 2.40345771995892 0.5 9.2 9 2 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.0177215736181201 0.0579068412576695 2.40345771995892 0.5 9.2 9 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 8.79791980523652e-09 2.60821664226074e-07 2.3283496662102 0.484375 9.2 9 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.000377290201756987 0.00236512756431803 2.30731941116056 0.48 9.2 9 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.000688377131332819 0.00396583262302268 2.29895955822157 0.478260869565217 9.2 9 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 5.28610101420713e-06 5.96993789144187e-05 2.28900735234183 0.476190476190476 9.2 9 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00125993689864567 0.00681707302955431 2.28900735234183 0.476190476190476 9.2 9 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00231474219589604 0.011437076891528 2.27695994522424 0.473684210526316 9.2 9 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00231474219589604 0.011437076891528 2.27695994522424 0.473684210526316 9.2 9 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 5.53287500264851e-05 0.000455102955420164 2.26207785407898 0.470588235294118 9.2 9 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00427196262144039 0.0188204421371817 2.26207785407898 0.470588235294118 9.2 9 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00427196262144039 0.0188204421371817 2.26207785407898 0.470588235294118 9.2 9 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 2.33840352331371e-28 1.66377410683771e-25 2.26207785407898 0.470588235294118 9.2 9 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0079282698995111 0.0313022365768521 2.24322720529499 0.466666666666667 9.2 9 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0079282698995111 0.0313022365768521 2.24322720529499 0.466666666666667 9.2 9 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0079282698995111 0.0313022365768521 2.24322720529499 0.466666666666667 9.2 9 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.08948021995942e-08 3.07442469805128e-07 2.23420013404632 0.464788732394366 9.2 9 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.000591319769305761 0.00344855750705778 2.21857635688516 0.461538461538462 9.2 9 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000591319769305761 0.00344855750705778 2.21857635688516 0.461538461538462 9.2 9 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.000591319769305761 0.00344855750705778 2.21857635688516 0.461538461538462 9.2 9 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.000591319769305761 0.00344855750705778 2.21857635688516 0.461538461538462 9.2 9 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0148178747549782 0.0500851206088693 2.21857635688516 0.461538461538462 9.2 9 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0148178747549782 0.0500851206088693 2.21857635688516 0.461538461538462 9.2 9 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.0148178747549782 0.0500851206088693 2.21857635688516 0.461538461538462 9.2 9 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.95740637213229e-19 3.48173658443032e-17 2.20645298881474 0.459016393442623 9.2 9 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00107408619794771 0.005856033178849 2.20316957662901 0.458333333333333 9.2 9 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.00107408619794771 0.005856033178849 2.20316957662901 0.458333333333333 9.2 9 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 8.56667463981749e-05 0.00066614087499783 2.19744705824815 0.457142857142857 9.2 9 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 8.56667463981749e-05 0.00066614087499783 2.19744705824815 0.457142857142857 9.2 9 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 7.13491689266619e-06 7.69165661989697e-05 2.19446139648423 0.456521739130435 9.2 9 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 5.04967738108133e-13 3.78194258593617e-11 2.18496156359902 0.454545454545455 9.2 9 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 5.04967738108133e-13 3.78194258593617e-11 2.18496156359902 0.454545454545455 9.2 9 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000153931296204494 0.00111189966750759 2.18496156359902 0.454545454545455 9.2 9 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.000153931296204494 0.00111189966750759 2.18496156359902 0.454545454545455 9.2 9 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00195565064385032 0.00983353662967849 2.18496156359902 0.454545454545455 9.2 9 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.0279485267339854 0.0853449646833932 2.18496156359902 0.454545454545455 9.2 9 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0279485267339854 0.0853449646833932 2.18496156359902 0.454545454545455 9.2 9 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.76690136558217e-16 2.28572785747585e-14 2.17671642562317 0.452830188679245 9.2 9 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000276857842189328 0.00179894387870052 2.17086503738225 0.451612903225806 9.2 9 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.20841327825958e-07 8.51904838501539e-06 2.16311194796303 0.45 9.2 9 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.20841327825958e-07 8.51904838501539e-06 2.16311194796303 0.45 9.2 9 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.20841327825958e-07 8.51904838501539e-06 2.16311194796303 0.45 9.2 9 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.20841327825958e-07 8.51904838501539e-06 2.16311194796303 0.45 9.2 9 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.20841327825958e-07 8.51904838501539e-06 2.16311194796303 0.45 9.2 9 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.20841327825958e-07 8.51904838501539e-06 2.16311194796303 0.45 9.2 9 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.20841327825958e-07 8.51904838501539e-06 2.16311194796303 0.45 9.2 9 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00357061095548224 0.0163375543075602 2.16311194796303 0.45 9.2 9 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.09033969583806e-09 3.978342018404e-08 2.16041143367094 0.449438202247191 9.2 9 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.00049847118249915 0.00298035501132895 2.15482416272179 0.448275862068966 9.2 9 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.24191995158617e-15 1.26232292221937e-13 2.14321070569585 0.445859872611465 9.2 9 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 7.8737591086506e-26 2.24087184232196e-23 2.13837047143404 0.444852941176471 9.2 9 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 6.80181527025925e-08 1.4233798719969e-06 2.13640686218571 0.444444444444444 9.2 9 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.000898499995181297 0.00493654630557137 2.13640686218571 0.444444444444444 9.2 9 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00654026709739427 0.026590857370263 2.13640686218571 0.444444444444444 9.2 9 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00162156876638328 0.00830033221065973 2.11504279356385 0.44 9.2 9 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 6.07553758954339e-05 0.000488445762142387 2.11035311996393 0.439024390243902 9.2 9 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 6.07553758954339e-05 0.000488445762142387 2.11035311996393 0.439024390243902 9.2 9 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 1.61047497229715e-05 0.000163693277541346 2.10302550496405 0.4375 9.2 9 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000414564828097464 0.00257609497983708 2.10302550496405 0.4375 9.2 9 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0120255187347695 0.0421485545802389 2.10302550496405 0.4375 9.2 9 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0120255187347695 0.0421485545802389 2.10302550496405 0.4375 9.2 9 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0120255187347695 0.0421485545802389 2.10302550496405 0.4375 9.2 9 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0120255187347695 0.0421485545802389 2.10302550496405 0.4375 9.2 9 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0120255187347695 0.0421485545802389 2.10302550496405 0.4375 9.2 9 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.75147363276117e-08 6.75059824037784e-07 2.10302550496405 0.4375 9.2 9 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.31633082099304e-08 3.53422407221339e-07 2.09242201502306 0.435294117647059 9.2 9 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 2.85120477181514e-05 0.000276004380292037 2.08996323474689 0.434782608695652 9.2 9 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000741782671440851 0.00422222696584132 2.08299669063106 0.433333333333333 9.2 9 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.000741782671440851 0.00422222696584132 2.08299669063106 0.433333333333333 9.2 9 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000741782671440851 0.00422222696584132 2.08299669063106 0.433333333333333 9.2 9 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 5.49523340403771e-07 8.88604219766552e-06 2.0806051904122 0.432835820895522 9.2 9 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 4.04400896521747e-08 9.75360128390587e-07 2.07706222712499 0.432098765432099 9.2 9 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 1.10186689810692e-08 3.07442469805128e-07 2.07571348541907 0.431818181818182 9.2 9 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.5363599815558e-14 1.36640015859619e-12 2.07298228346457 0.43125 9.2 9 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.40443760265095e-19 2.85502101224615e-17 2.0693447633727 0.430493273542601 9.2 9 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 1.69380989740399e-06 2.36251340994969e-05 2.06010661710764 0.428571428571429 9.2 9 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.07261562472534e-12 7.63166016992077e-11 2.06010661710764 0.428571428571429 9.2 9 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00132771190882873 0.00712956243872939 2.06010661710764 0.428571428571429 9.2 9 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.022212054418508 0.0697742901490881 2.06010661710764 0.428571428571429 9.2 9 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.022212054418508 0.0697742901490881 2.06010661710764 0.428571428571429 9.2 9 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.022212054418508 0.0697742901490881 2.06010661710764 0.428571428571429 9.2 9 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.022212054418508 0.0697742901490881 2.06010661710764 0.428571428571429 9.2 9 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.16801588993119e-07 3.95523924534882e-06 2.05095058769828 0.426666666666667 9.2 9 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.16801588993119e-07 3.95523924534882e-06 2.05095058769828 0.426666666666667 9.2 9 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.16801588993119e-07 3.95523924534882e-06 2.05095058769828 0.426666666666667 9.2 9 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.16801588993119e-07 3.95523924534882e-06 2.05095058769828 0.426666666666667 9.2 9 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.16801588993119e-07 3.95523924534882e-06 2.05095058769828 0.426666666666667 9.2 9 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 4.87975045080381e-08 1.05210377143846e-06 2.03587006867108 0.423529411764706 9.2 9 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 4.87975045080381e-08 1.05210377143846e-06 2.03587006867108 0.423529411764706 9.2 9 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 4.87975045080381e-08 1.05210377143846e-06 2.03587006867108 0.423529411764706 9.2 9 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 4.87975045080381e-08 1.05210377143846e-06 2.03587006867108 0.423529411764706 9.2 9 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 4.87975045080381e-08 1.05210377143846e-06 2.03587006867108 0.423529411764706 9.2 9 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.00237708469757346 0.0114782607868801 2.03369499381139 0.423076923076923 9.2 9 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00237708469757346 0.0114782607868801 2.03369499381139 0.423076923076923 9.2 9 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00237708469757346 0.0114782607868801 2.03369499381139 0.423076923076923 9.2 9 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 7.32937441722285e-05 0.00058266479305632 2.02958651907642 0.422222222222222 9.2 9 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00961337611666568 0.0356245682656648 2.02396439575488 0.421052631578947 9.2 9 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 3.41451537663905e-05 0.000323923692063824 2.01890448476549 0.42 9.2 9 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.29590878970261e-29 1.84407820774682e-26 2.01787626755909 0.419786096256685 9.2 9 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000128947064950229 0.000976019539490297 2.01219716089584 0.418604651162791 9.2 9 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 9.63401701064886e-12 6.23145736643333e-10 2.00576327708802 0.41726618705036 9.2 9 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 5.98549487448122e-05 0.000487232214348945 2.0028814332991 0.416666666666667 9.2 9 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000492589661671059 0.00295761640741737 2.0028814332991 0.416666666666667 9.2 9 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00425646944039726 0.0188204421371817 2.0028814332991 0.416666666666667 9.2 9 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.00425646944039726 0.0188204421371817 2.0028814332991 0.416666666666667 9.2 9 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0412533752433704 0.114655376897102 2.0028814332991 0.416666666666667 9.2 9 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0412533752433704 0.114655376897102 2.0028814332991 0.416666666666667 9.2 9 2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0412533752433704 0.114655376897102 2.0028814332991 0.416666666666667 9.2 9 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0412533752433704 0.114655376897102 2.0028814332991 0.416666666666667 9.2 9 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0412533752433704 0.114655376897102 2.0028814332991 0.416666666666667 9.2 9 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0412533752433704 0.114655376897102 2.0028814332991 0.416666666666667 9.2 9 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.0412533752433704 0.114655376897102 2.0028814332991 0.416666666666667 9.2 9 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0412533752433704 0.114655376897102 2.0028814332991 0.416666666666667 9.2 9 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000226636578355349 0.00151410258685287 1.99311127996593 0.414634146341463 9.2 9 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.79946868733176e-12 1.21935425813004e-10 1.99233995207121 0.414473684210526 9.2 9 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.36977805911616e-11 7.79677671248921e-10 1.99143639653739 0.414285714285714 9.2 9 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 1.30232149575365e-05 0.000134290107859236 1.98906845789704 0.413793103448276 9.2 9 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 1.30232149575365e-05 0.000134290107859236 1.98906845789704 0.413793103448276 9.2 9 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.00191305830388491 0.00965348215045468 1.98906845789704 0.413793103448276 9.2 9 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 4.71783667911743e-08 1.05210377143846e-06 1.98546507300954 0.41304347826087 9.2 9 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0174530080140999 0.0579068412576695 1.97931812231911 0.411764705882353 9.2 9 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0174530080140999 0.0579068412576695 1.97931812231911 0.411764705882353 9.2 9 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0174530080140999 0.0579068412576695 1.97931812231911 0.411764705882353 9.2 9 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.33668178002122e-11 1.75855487887785e-09 1.97118115162098 0.410071942446043 9.2 9 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 4.21784788806754e-16 4.61692118824624e-14 1.96854632301397 0.40952380952381 9.2 9 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.54323320767865e-10 1.03400595843621e-08 1.96818584941518 0.409448818897638 9.2 9 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00018328314736662 0.00127225326196439 1.96646540723911 0.409090909090909 9.2 9 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.00018328314736662 0.00127225326196439 1.96646540723911 0.409090909090909 9.2 9 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00339361168046806 0.0155777723267937 1.95837295700356 0.407407407407407 9.2 9 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 7.51969121837148e-10 2.81592647466911e-08 1.95403066663327 0.40650406504065 9.2 9 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00153119116357824 0.00798126383066607 1.95280939746662 0.40625 9.2 9 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 8.89204181213954e-07 1.34610377645474e-05 1.94710498832115 0.40506329113924 9.2 9 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 8.89204181213954e-07 1.34610377645474e-05 1.94710498832115 0.40506329113924 9.2 9 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 8.89204181213954e-07 1.34610377645474e-05 1.94710498832115 0.40506329113924 9.2 9 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.00601306988973992 0.0245174740776502 1.92276617596713 0.4 9.2 9 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.00601306988973992 0.0245174740776502 1.92276617596713 0.4 9.2 9 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.00601306988973992 0.0245174740776502 1.92276617596713 0.4 9.2 9 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00269390872551429 0.0127356548717835 1.92276617596713 0.4 9.2 9 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0317345774311727 0.0948606390500072 1.92276617596713 0.4 9.2 9 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0317345774311727 0.0948606390500072 1.92276617596713 0.4 9.2 9 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0317345774311727 0.0948606390500072 1.92276617596713 0.4 9.2 9 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0136418862241214 0.047003399750423 1.92276617596713 0.4 9.2 9 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.26282189000947e-10 5.98964367612548e-09 1.91604321730991 0.398601398601399 9.2 9 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000205220009219472 0.00138401930388298 1.90273736163414 0.395833333333333 9.2 9 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.000205220009219472 0.00138401930388298 1.90273736163414 0.395833333333333 9.2 9 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00044499183891585 0.00274122678258552 1.90040842973496 0.395348837209302 9.2 9 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.71004132975979e-06 2.36251340994969e-05 1.89902832194285 0.395061728395062 9.2 9 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.71004132975979e-06 2.36251340994969e-05 1.89902832194285 0.395061728395062 9.2 9 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.00213216853741833 0.0106086567438681 1.89363335511915 0.393939393939394 9.2 9 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00213216853741833 0.0106086567438681 1.89363335511915 0.393939393939394 9.2 9 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00213216853741833 0.0106086567438681 1.89363335511915 0.393939393939394 9.2 9 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00473037035623469 0.0205850673300366 1.88843106568201 0.392857142857143 9.2 9 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.000163783364040778 0.00115378082688132 1.88506487839915 0.392156862745098 9.2 9 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.000163783364040778 0.00115378082688132 1.88506487839915 0.392156862745098 9.2 9 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000163783364040778 0.00115378082688132 1.88506487839915 0.392156862745098 9.2 9 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.97448350820584e-07 3.90234726691238e-06 1.87469702156796 0.39 9.2 9 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00168413143716042 0.00858967396085765 1.86935600441249 0.388888888888889 9.2 9 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0243974795065489 0.0756375018253138 1.86935600441249 0.388888888888889 9.2 9 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.87725864768592e-06 2.52013118458214e-05 1.86621422961516 0.388235294117647 9.2 9 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.87725864768592e-06 2.52013118458214e-05 1.86621422961516 0.388235294117647 9.2 9 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.87725864768592e-06 2.52013118458214e-05 1.86621422961516 0.388235294117647 9.2 9 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.000281459426297853 0.00181229304806265 1.86390598690692 0.387755102040816 9.2 9 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.000281459426297853 0.00181229304806265 1.86390598690692 0.387755102040816 9.2 9 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 7.09118182935597e-07 1.12119463813039e-05 1.86074146061336 0.387096774193548 9.2 9 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00371475946913014 0.0168885071072594 1.86074146061336 0.387096774193548 9.2 9 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 6.98053784773966e-09 2.11346922496458e-07 1.84881363073763 0.384615384615385 9.2 9 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.14845832613849e-07 3.95523924534882e-06 1.84881363073763 0.384615384615385 9.2 9 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00828556063484395 0.0313022365768521 1.84881363073763 0.384615384615385 9.2 9 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0577755630486154 0.150365046296813 1.84881363073763 0.384615384615385 9.2 9 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0577755630486154 0.150365046296813 1.84881363073763 0.384615384615385 9.2 9 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0577755630486154 0.150365046296813 1.84881363073763 0.384615384615385 9.2 9 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0577755630486154 0.150365046296813 1.84881363073763 0.384615384615385 9.2 9 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.0577755630486154 0.150365046296813 1.84881363073763 0.384615384615385 9.2 9 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.54483200610468e-06 3.32228985751097e-05 1.84451406415452 0.383720930232558 9.2 9 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.54483200610468e-06 3.32228985751097e-05 1.84451406415452 0.383720930232558 9.2 9 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 3.06819591484382e-05 0.00029302300582703 1.83793825643917 0.382352941176471 9.2 9 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00291413297682577 0.0135961023804035 1.83793825643917 0.382352941176471 9.2 9 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.000177074245187372 0.00124126429015581 1.83536771342317 0.381818181818182 9.2 9 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 2.72606287773628e-06 3.52653406819884e-05 1.81594583285785 0.377777777777778 9.2 9 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000301113085138664 0.00193010774843387 1.81393035468598 0.377358490566038 9.2 9 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.12154049114759e-05 0.000353310368608616 1.81130147011397 0.376811594202899 9.2 9 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 5.76538513228709e-06 6.35980080871669e-05 1.80966228326319 0.376470588235294 9.2 9 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.76538513228709e-06 6.35980080871669e-05 1.80966228326319 0.376470588235294 9.2 9 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 5.76538513228709e-06 6.35980080871669e-05 1.80966228326319 0.376470588235294 9.2 9 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.000648675794409588 0.00376761492018304 1.80259328996919 0.375 9.2 9 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0144654108483719 0.0492446881273521 1.80259328996919 0.375 9.2 9 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0144654108483719 0.0492446881273521 1.80259328996919 0.375 9.2 9 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0435600126490146 0.11851988145229 1.80259328996919 0.375 9.2 9 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 6.50465168899254e-07 1.04001341049847e-05 1.80259328996919 0.375 9.2 9 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.41086758641667e-10 2.81592647466911e-08 1.80259328996919 0.375 9.2 9 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.00179063968638526 0.00906790132998657 1.80259328996919 0.375 9.2 9 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.00179063968638526 0.00906790132998657 1.80259328996919 0.375 9.2 9 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.55049223834633e-09 5.51587613791706e-08 1.79871674525958 0.374193548387097 9.2 9 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 4.69563060546438e-08 1.05210377143846e-06 1.78861969857408 0.372093023255814 9.2 9 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.000147939266424545 0.00108514214495942 1.78321056642113 0.370967741935484 9.2 9 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0111631776668297 0.0396139696256826 1.78033905182142 0.37037037037037 9.2 9 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0111631776668297 0.0396139696256826 1.78033905182142 0.37037037037037 9.2 9 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0111631776668297 0.0396139696256826 1.78033905182142 0.37037037037037 9.2 9 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0111631776668297 0.0396139696256826 1.78033905182142 0.37037037037037 9.2 9 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.0111631776668297 0.0396139696256826 1.78033905182142 0.37037037037037 9.2 9 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000116666748471235 0.000892563349863266 1.77486108550812 0.369230769230769 9.2 9 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00305130531188167 0.0141895668588484 1.77096884628552 0.368421052631579 9.2 9 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0330215398173141 0.0978951065834124 1.77096884628552 0.368421052631579 9.2 9 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 9.03774157341844e-07 1.35375855357626e-05 1.76400566602489 0.36697247706422 9.2 9 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00237954106263502 0.0114782607868801 1.75862759996994 0.365853658536585 9.2 9 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00237954106263502 0.0114782607868801 1.75862759996994 0.365853658536585 9.2 9 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00237954106263502 0.0114782607868801 1.75862759996994 0.365853658536585 9.2 9 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 6.3446237422819e-06 6.9449227578978e-05 1.75736693502373 0.365591397849462 9.2 9 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 1.30484155980246e-10 5.98964367612548e-09 1.75252125413671 0.364583333333333 9.2 9 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 1.33263644486138e-05 0.000136427457628615 1.74796925087921 0.363636363636364 9.2 9 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.81538369941912e-07 5.00786375534177e-06 1.74444511932502 0.362903225806452 9.2 9 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.0014495226840761 0.00761133128944758 1.73867154209794 0.361702127659574 9.2 9 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 1.00731523234463e-08 2.92532566454368e-07 1.73414038022352 0.360759493670886 9.2 9 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.6530285334015e-08 4.20046357683987e-07 1.72555938868845 0.358974358974359 9.2 9 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.0040161574028146 0.0179716729063056 1.72555938868845 0.358974358974359 9.2 9 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 4.62884384046083e-05 0.00038746145793975 1.72099441676071 0.358024691358025 9.2 9 2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.0775330678431195 0.184580077245691 1.71675551425637 0.357142857142857 9.2 9 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0775330678431195 0.184580077245691 1.71675551425637 0.357142857142857 9.2 9 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0775330678431195 0.184580077245691 1.71675551425637 0.357142857142857 9.2 9 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0775330678431195 0.184580077245691 1.71675551425637 0.357142857142857 9.2 9 2 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.0775330678431195 0.184580077245691 1.71675551425637 0.357142857142857 9.2 9 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0775330678431195 0.184580077245691 1.71675551425637 0.357142857142857 9.2 9 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0775330678431195 0.184580077245691 1.71675551425637 0.357142857142857 9.2 9 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0775330678431195 0.184580077245691 1.71675551425637 0.357142857142857 9.2 9 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 9.87268527169419e-07 1.4634199105855e-05 1.70824267699559 0.355371900826446 9.2 9 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 3.29074625779026e-06 3.80709912588255e-05 1.70427001960723 0.354545454545455 9.2 9 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 5.99196328257662e-05 0.000487232214348945 1.70000667997094 0.353658536585366 9.2 9 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0578001969953317 0.150365046296813 1.69655839055924 0.352941176470588 9.2 9 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.0578001969953317 0.150365046296813 1.69655839055924 0.352941176470588 9.2 9 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0578001969953317 0.150365046296813 1.69655839055924 0.352941176470588 9.2 9 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0578001969953317 0.150365046296813 1.69655839055924 0.352941176470588 9.2 9 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 6.82726728101424e-06 7.41618422968188e-05 1.69386544073295 0.352380952380952 9.2 9 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0434567379059563 0.118465398544398 1.68242040397124 0.35 9.2 9 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0434567379059563 0.118465398544398 1.68242040397124 0.35 9.2 9 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.0031338830765243 0.0144789468113444 1.67197058779751 0.347826086956522 9.2 9 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.00243418353216507 0.011623634786144 1.66770535670619 0.346938775510204 9.2 9 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.000160321606678872 0.0011464203331861 1.66393226766387 0.346153846153846 9.2 9 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0250085954625922 0.0771957295949428 1.66393226766387 0.346153846153846 9.2 9 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0250085954625922 0.0771957295949428 1.66393226766387 0.346153846153846 9.2 9 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.000125634931833444 0.000956034802133644 1.66164978169999 0.345679012345679 9.2 9 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 4.02756677451534e-10 1.59200764448204e-08 1.66057078833525 0.345454545454545 9.2 9 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00147331182715502 0.0077078041545647 1.66057078833525 0.345454545454545 9.2 9 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0190974323750789 0.0616227806570005 1.65755704824753 0.344827586206897 9.2 9 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 1.40865980250478e-08 3.644587089026e-07 1.65483974161106 0.344262295081967 9.2 9 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.51479973347056e-07 3.03600002919522e-06 1.65333397296537 0.343949044585987 9.2 9 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.35671475249832e-11 1.28984811261735e-09 1.64544413135649 0.342307692307692 9.2 9 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 1.40720373915516e-08 3.644587089026e-07 1.64514753023926 0.342245989304813 9.2 9 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.000260608445723536 0.00170112760671831 1.64447107155084 0.342105263157895 9.2 9 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 4.27007368686554e-06 4.86105188512773e-05 1.64138575997194 0.341463414634146 9.2 9 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 3.80697456512684e-18 6.01924978463943e-16 1.63823127100339 0.340807174887892 9.2 9 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00113641406134147 0.00617220308888896 1.62814877803669 0.338709677419355 9.2 9 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.19622200741796e-20 2.83703986092627e-18 1.6203085752532 0.337078651685393 9.2 9 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000869889618182281 0.00481654835281473 1.60230514663928 0.333333333333333 9.2 9 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.000869889618182281 0.00481654835281473 1.60230514663928 0.333333333333333 9.2 9 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0142776012643329 0.0488390062479465 1.60230514663928 0.333333333333333 9.2 9 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.0142776012643329 0.0488390062479465 1.60230514663928 0.333333333333333 9.2 9 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0186101169258568 0.0603239097619459 1.60230514663928 0.333333333333333 9.2 9 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0186101169258568 0.0603239097619459 1.60230514663928 0.333333333333333 9.2 9 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0319313043604733 0.0948606390500072 1.60230514663928 0.333333333333333 9.2 9 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0319313043604733 0.0948606390500072 1.60230514663928 0.333333333333333 9.2 9 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0319313043604733 0.0948606390500072 1.60230514663928 0.333333333333333 9.2 9 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.042092352338758 0.115409282038637 1.60230514663928 0.333333333333333 9.2 9 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.042092352338758 0.115409282038637 1.60230514663928 0.333333333333333 9.2 9 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0745015557397233 0.184580077245691 1.60230514663928 0.333333333333333 9.2 9 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0745015557397233 0.184580077245691 1.60230514663928 0.333333333333333 9.2 9 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0745015557397233 0.184580077245691 1.60230514663928 0.333333333333333 9.2 9 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.100432313049093 0.22541826730104 1.60230514663928 0.333333333333333 9.2 9 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.100432313049093 0.22541826730104 1.60230514663928 0.333333333333333 9.2 9 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.100432313049093 0.22541826730104 1.60230514663928 0.333333333333333 9.2 9 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00846674313636055 0.0315397263953954 1.60230514663928 0.333333333333333 9.2 9 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0109824093624918 0.0394645669768328 1.60230514663928 0.333333333333333 9.2 9 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0557985422927164 0.147586107216609 1.60230514663928 0.333333333333333 9.2 9 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 5.08299667779872e-09 1.64997534732679e-07 1.59511992176646 0.331838565022422 9.2 9 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 9.33187102478654e-05 0.000721698503710394 1.58628209517289 0.33 9.2 9 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 2.12844829239638e-05 0.000213294501414088 1.57603784915339 0.327868852459016 9.2 9 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.00210710930996e-17 4.27199841654807e-15 1.57299468663978 0.327235772357724 9.2 9 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 2.12874551574136e-26 7.5730121722499e-24 1.56947943300774 0.326504481434059 9.2 9 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.010603939075026 0.0382010260854733 1.56504223625232 0.325581395348837 9.2 9 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0137595446017806 0.0472942801167483 1.5622475179733 0.325 9.2 9 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.39519549390385e-07 1.31278716349727e-05 1.54798971793964 0.322033898305085 9.2 9 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 5.21777165352814e-09 1.64997534732679e-07 1.54507996283073 0.321428571428571 9.2 9 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 5.21777165352814e-09 1.64997534732679e-07 1.54507996283073 0.321428571428571 9.2 9 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 5.21777165352814e-09 1.64997534732679e-07 1.54507996283073 0.321428571428571 9.2 9 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0400759940283583 0.113151070441178 1.54507996283073 0.321428571428571 9.2 9 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0400759940283583 0.113151070441178 1.54507996283073 0.321428571428571 9.2 9 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0400759940283583 0.113151070441178 1.54507996283073 0.321428571428571 9.2 9 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.00129898246207465 0.00700171228610694 1.53821294077371 0.32 9.2 9 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0528558816098902 0.141948128126599 1.53821294077371 0.32 9.2 9 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0701032844022234 0.175938225228155 1.52947309451931 0.318181818181818 9.2 9 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0170443873905493 0.0573384474154887 1.52414391997395 0.317073170731707 9.2 9 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.000351013252770009 0.00221014096766249 1.52055488405564 0.316326530612245 9.2 9 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 8.44107210885389e-06 9.03131248939781e-05 1.51960552616757 0.316129032258064 9.2 9 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0936461784731425 0.212873022311952 1.51797329681616 0.315789473684211 9.2 9 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0936461784731425 0.212873022311952 1.51797329681616 0.315789473684211 9.2 9 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0936461784731425 0.212873022311952 1.51797329681616 0.315789473684211 9.2 9 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.47451367711422e-06 2.11942723488236e-05 1.51522334519149 0.315217391304348 9.2 9 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0288768747432421 0.0879909909199862 1.51074485254561 0.314285714285714 9.2 9 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.000427721618502318 0.00264629505708173 1.50519574381266 0.313131313131313 9.2 9 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.00429771463670869 0.0188754565680138 1.50216107497432 0.3125 9.2 9 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.126283358685492 0.264655698688447 1.50216107497432 0.3125 9.2 9 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.126283358685492 0.264655698688447 1.50216107497432 0.3125 9.2 9 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.126283358685492 0.264655698688447 1.50216107497432 0.3125 9.2 9 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.126283358685492 0.264655698688447 1.50216107497432 0.3125 9.2 9 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.126283358685492 0.264655698688447 1.50216107497432 0.3125 9.2 9 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.41775155154128e-27 6.72486819281081e-25 1.49163542179633 0.31031031031031 9.2 9 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.00912829579834059 0.0339153131097615 1.48577386324733 0.309090909090909 9.2 9 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0652324532309117 0.16635444614263 1.4790509045901 0.307692307692308 9.2 9 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0652324532309117 0.16635444614263 1.4790509045901 0.307692307692308 9.2 9 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0652324532309117 0.16635444614263 1.4790509045901 0.307692307692308 9.2 9 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0353005550739622 0.102515693612751 1.46877971775267 0.305555555555556 9.2 9 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0863869961473373 0.199559570645554 1.46297426432282 0.304347826086957 9.2 9 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0863869961473373 0.199559570645554 1.46297426432282 0.304347826086957 9.2 9 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0460673329338733 0.124864409076003 1.45664104239934 0.303030303030303 9.2 9 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000560072217385226 0.00332076152224657 1.45530467447054 0.302752293577982 9.2 9 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0253466312446228 0.0780698187469659 1.45325350509144 0.302325581395349 9.2 9 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.00807172599882163 0.0313022365768521 1.44970465648316 0.301587301587302 9.2 9 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.00462641694318405 0.0201944518716285 1.44865944764647 0.301369863013699 9.2 9 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00267007767976525 0.0126650684610199 1.44786609636079 0.301204819277108 9.2 9 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.000669559777222985 0.00387310391458662 1.44207463197535 0.3 9.2 9 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.00591127525777611 0.0243114008433971 1.44207463197535 0.3 9.2 9 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00591127525777611 0.0243114008433971 1.44207463197535 0.3 9.2 9 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.115155938716223 0.246416392170203 1.44207463197535 0.3 9.2 9 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.115155938716223 0.246416392170203 1.44207463197535 0.3 9.2 9 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.115155938716223 0.246416392170203 1.44207463197535 0.3 9.2 9 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.115155938716223 0.246416392170203 1.44207463197535 0.3 9.2 9 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.115155938716223 0.246416392170203 1.44207463197535 0.3 9.2 9 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.00755669358328352 0.0305487925256036 1.43490013131876 0.298507462686567 9.2 9 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0792539895974121 0.184580077245691 1.42427124145714 0.296296296296296 9.2 9 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0792539895974121 0.184580077245691 1.42427124145714 0.296296296296296 9.2 9 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0792539895974121 0.184580077245691 1.42427124145714 0.296296296296296 9.2 9 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0792539895974121 0.184580077245691 1.42427124145714 0.296296296296296 9.2 9 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.0123689534110181 0.0430342804495813 1.41843406423805 0.295081967213115 9.2 9 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0123689534110181 0.0430342804495813 1.41843406423805 0.295081967213115 9.2 9 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.0123689534110181 0.0430342804495813 1.41843406423805 0.295081967213115 9.2 9 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0555391448206196 0.147173562532108 1.41379865879936 0.294117647058824 9.2 9 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.154818009389726 0.304710964538838 1.41379865879936 0.294117647058824 9.2 9 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.154818009389726 0.304710964538838 1.41379865879936 0.294117647058824 9.2 9 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.154818009389726 0.304710964538838 1.41379865879936 0.294117647058824 9.2 9 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.154818009389726 0.304710964538838 1.41379865879936 0.294117647058824 9.2 9 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.000384686693684789 0.00240091739084849 1.40954663275786 0.293233082706767 9.2 9 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.0158385130294606 0.0534080664476834 1.4089234910104 0.293103448275862 9.2 9 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 4.1873284479937e-06 4.80529708185084e-05 1.40287660907473 0.291845493562232 9.2 9 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00838099236527103 0.0313022365768521 1.40201700330937 0.291666666666667 9.2 9 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.020294195055683 0.0646054576381138 1.39837540070337 0.290909090909091 9.2 9 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0724946305367764 0.180982209217251 1.39555609546002 0.290322580645161 9.2 9 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0724946305367764 0.180982209217251 1.39555609546002 0.290322580645161 9.2 9 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00242443653643601 0.011623634786144 1.39400547757617 0.29 9.2 9 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.00778589676394471 0.0313022365768521 1.39147552208148 0.289473684210526 9.2 9 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00417444515069966 0.0186214277412088 1.38866446042071 0.288888888888889 9.2 9 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0260209157320584 0.0799735703816828 1.38661022305322 0.288461538461538 9.2 9 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.018769111513819 0.0607010129185554 1.38504343184073 0.288135593220339 9.2 9 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.98362536672631e-05 0.000286871547084563 1.3734044114051 0.285714285714286 9.2 9 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.0173362413220727 0.0579068412576695 1.3734044114051 0.285714285714286 9.2 9 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.0239922707340161 0.0747067861148903 1.3734044114051 0.285714285714286 9.2 9 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0333875244767791 0.0985693928017772 1.3734044114051 0.285714285714286 9.2 9 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0662040528515708 0.168229227156759 1.3734044114051 0.285714285714286 9.2 9 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0662040528515708 0.168229227156759 1.3734044114051 0.285714285714286 9.2 9 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0949251878250335 0.214751259578732 1.3734044114051 0.285714285714286 9.2 9 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0949251878250335 0.214751259578732 1.3734044114051 0.285714285714286 9.2 9 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.138898897285625 0.282390830665453 1.3734044114051 0.285714285714286 9.2 9 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.0220985178835587 0.0697742901490881 1.36195937464339 0.283333333333333 9.2 9 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.0428720139394425 0.117320915068898 1.35847610258548 0.282608695652174 9.2 9 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.00783807311222679 0.0313022365768521 1.35724671244739 0.282352941176471 9.2 9 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.00783807311222679 0.0313022365768521 1.35724671244739 0.282352941176471 9.2 9 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0860915433546731 0.199524863507654 1.35194496747689 0.28125 9.2 9 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00990529057313576 0.0363279084679695 1.34828115997695 0.280487804878049 9.2 9 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.0125140871800619 0.0433273626696547 1.33863467947079 0.278481012658228 9.2 9 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0125140871800619 0.0433273626696547 1.33863467947079 0.278481012658228 9.2 9 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0359267675816312 0.104121772441265 1.33525428886607 0.277777777777778 9.2 9 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.185708953101265 0.353766854435208 1.33525428886607 0.277777777777778 9.2 9 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.185708953101265 0.353766854435208 1.33525428886607 0.277777777777778 9.2 9 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.0237223437445133 0.0740282788343037 1.33114581413109 0.276923076923077 9.2 9 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.112223793940347 0.242696745861876 1.32604563859802 0.275862068965517 9.2 9 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.0106005289135918 0.0382010260854733 1.32604563859802 0.275862068965517 9.2 9 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.0106005289135918 0.0382010260854733 1.32604563859802 0.275862068965517 9.2 9 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.00242678710812292 0.011623634786144 1.32474047556791 0.275590551181102 9.2 9 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 7.82562501306991e-08 1.61389339037659e-06 1.32020917011828 0.274647887323944 9.2 9 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.0458178082189439 0.124425078426636 1.31954541487941 0.274509803921569 9.2 9 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.00824894052160935 0.0313022365768521 1.31097693815941 0.272727272727273 9.2 9 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.00557911495935072 0.0230787226370816 1.31097693815941 0.272727272727273 9.2 9 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.0417889822788617 0.115020738458066 1.31097693815941 0.272727272727273 9.2 9 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0417889822788617 0.115020738458066 1.31097693815941 0.272727272727273 9.2 9 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.0417889822788617 0.115020738458066 1.31097693815941 0.272727272727273 9.2 9 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.0417889822788617 0.115020738458066 1.31097693815941 0.272727272727273 9.2 9 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.0417889822788617 0.115020738458066 1.31097693815941 0.272727272727273 9.2 9 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.0643302098724664 0.164940339907243 1.31097693815941 0.272727272727273 9.2 9 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.0643302098724664 0.164940339907243 1.31097693815941 0.272727272727273 9.2 9 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.1646972521169 0.32060764673372 1.31097693815941 0.272727272727273 9.2 9 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.1646972521169 0.32060764673372 1.31097693815941 0.272727272727273 9.2 9 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.1646972521169 0.32060764673372 1.31097693815941 0.272727272727273 9.2 9 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0381220718144089 0.110035919253355 1.30357028879128 0.271186440677966 9.2 9 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0381220718144089 0.110035919253355 1.30357028879128 0.271186440677966 9.2 9 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.0230356134850118 0.07204324832785 1.29916633511293 0.27027027027027 9.2 9 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.0230356134850118 0.07204324832785 1.29916633511293 0.27027027027027 9.2 9 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0912105876988546 0.208669881503971 1.29916633511293 0.27027027027027 9.2 9 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0912105876988546 0.208669881503971 1.29916633511293 0.27027027027027 9.2 9 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0912105876988546 0.208669881503971 1.29916633511293 0.27027027027027 9.2 9 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.12701994677932e-08 3.08413343128265e-07 1.29768439632763 0.269961977186312 9.2 9 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.0531114001877963 0.141948128126599 1.29416954151634 0.269230769230769 9.2 9 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.131101704868284 0.274349597099365 1.28184411731142 0.266666666666667 9.2 9 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 0.00140610878623293 0.00749398053486692 1.27994789820297 0.266272189349112 9.2 9 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0400109896945467 0.113151070441178 1.27683691372818 0.265625 9.2 9 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 0.00159838393043353 0.00821119253793112 1.27241879291943 0.264705882352941 9.2 9 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.11750275414154 0.250684286571832 1.27241879291943 0.264705882352941 9.2 9 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.11750275414154 0.250684286571832 1.27241879291943 0.264705882352941 9.2 9 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0611629469195904 0.157958028070013 1.26975124828018 0.264150943396226 9.2 9 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.0332120641959599 0.0982552335776526 1.26849157442276 0.263888888888889 9.2 9 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.0302801661272015 0.0910965674397627 1.2649777473468 0.263157894736842 9.2 9 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.218588515468452 0.390768162703025 1.2649777473468 0.263157894736842 9.2 9 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.0129304764420326 0.0446603591675059 1.25788441418411 0.261682242990654 9.2 9 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0856975008800779 0.198935634180018 1.25397794084813 0.260869565217391 9.2 9 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.192336165988511 0.359650938504141 1.25397794084813 0.260869565217391 9.2 9 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 0.00020908726271064 0.00140344893791151 1.25237643645369 0.260536398467433 9.2 9 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.017536663529679 0.0579068412576695 1.24979801437864 0.26 9.2 9 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0699956096878765 0.175938225228155 1.24623733627499 0.259259259259259 9.2 9 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.170291968401471 0.330006583700717 1.24623733627499 0.259259259259259 9.2 9 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.063376229001704 0.163377488893886 1.24316778618565 0.258620689655172 9.2 9 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.047323189095267 0.127539579701828 1.23606397026459 0.257142857142857 9.2 9 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.135259996895761 0.282390830665453 1.23606397026459 0.257142857142857 9.2 9 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 9.60461817120723e-11 4.88120416343853e-09 1.23435498287483 0.256787330316742 9.2 9 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.12113623118801 0.257278891015729 1.23254242049175 0.256410256410256 9.2 9 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.12113623118801 0.257278891015729 1.23254242049175 0.256410256410256 9.2 9 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.12113623118801 0.257278891015729 1.23254242049175 0.256410256410256 9.2 9 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.00360533324518038 0.016443555153499 1.22967604276968 0.255813953488372 9.2 9 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.0978537515379267 0.221025219743603 1.22729755912796 0.25531914893617 9.2 9 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0719856007701003 0.180344207563121 1.22209714574182 0.254237288135593 9.2 9 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.0590407025114932 0.152754399407009 1.21966511162094 0.253731343283582 9.2 9 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0590407025114932 0.152754399407009 1.21966511162094 0.253731343283582 9.2 9 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0590407025114932 0.152754399407009 1.21966511162094 0.253731343283582 9.2 9 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.0535509281140235 0.142169721466895 1.21865461857072 0.253521126760563 9.2 9 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 0.000315021346135422 0.00201020347780585 1.21403325103727 0.252559726962457 9.2 9 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.00657449662843516 0.0266538709466189 1.20910142967258 0.251533742331288 9.2 9 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.0813311947940156 0.189108317307 1.20172885997946 0.25 9.2 9 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0998984976143419 0.225286152306194 1.20172885997946 0.25 9.2 9 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.154316658015926 0.304710964538838 1.20172885997946 0.25 9.2 9 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.154316658015926 0.304710964538838 1.20172885997946 0.25 9.2 9 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.221572898942234 0.394676009087101 1.20172885997946 0.25 9.2 9 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.13789526366004 0.282390830665453 1.20172885997946 0.25 9.2 9 2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.195414228593617 0.363400233774003 1.20172885997946 0.25 9.2 9 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.195414228593617 0.363400233774003 1.20172885997946 0.25 9.2 9 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.253066041052529 0.432828096655947 1.20172885997946 0.25 9.2 9 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.253066041052529 0.432828096655947 1.20172885997946 0.25 9.2 9 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.253066041052529 0.432828096655947 1.20172885997946 0.25 9.2 9 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.253066041052529 0.432828096655947 1.20172885997946 0.25 9.2 9 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.253066041052529 0.432828096655947 1.20172885997946 0.25 9.2 9 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.12328511128879e-14 1.77731453727291e-12 1.18543686123216 0.246610716591349 9.2 9 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.0243268111616315 0.0755830835873399 1.18202838686504 0.245901639344262 9.2 9 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0914235752999978 0.208821424802403 1.18202838686504 0.245901639344262 9.2 9 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.0292232533138976 0.0888561740719577 1.18064589752368 0.245614035087719 9.2 9 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.112487551590136 0.242898005937425 1.17905473054588 0.245283018867925 9.2 9 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.15579787556576 0.304952375419637 1.17241839997996 0.24390243902439 9.2 9 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.15579787556576 0.304952375419637 1.17241839997996 0.24390243902439 9.2 9 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.15579787556576 0.304952375419637 1.17241839997996 0.24390243902439 9.2 9 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.15579787556576 0.304952375419637 1.17241839997996 0.24390243902439 9.2 9 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.0296139824306903 0.0893944081532324 1.17143317443376 0.243697478991597 9.2 9 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 8.54185405977547e-06 9.07093905004515e-05 1.17015980061047 0.243432574430823 9.2 9 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.196384244393681 0.363400233774003 1.16531283391948 0.242424242424242 9.2 9 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.196384244393681 0.363400233774003 1.16531283391948 0.242424242424242 9.2 9 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.196384244393681 0.363400233774003 1.16531283391948 0.242424242424242 9.2 9 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.102268242121947 0.227381843656398 1.16296341288335 0.241935483870968 9.2 9 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.22188391234693 0.394676009087101 1.16028993377327 0.241379310344828 9.2 9 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.22188391234693 0.394676009087101 1.16028993377327 0.241379310344828 9.2 9 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.125960606339633 0.264655698688447 1.15722038368392 0.240740740740741 9.2 9 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.140170877643443 0.282525720802578 1.15365970558028 0.24 9.2 9 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.140170877643443 0.282525720802578 1.15365970558028 0.24 9.2 9 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.252145779188654 0.432828096655947 1.15365970558028 0.24 9.2 9 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.252145779188654 0.432828096655947 1.15365970558028 0.24 9.2 9 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.156325087878296 0.305564011058811 1.14947977911079 0.239130434782609 9.2 9 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.00306462366906011 0.0142050797429073 1.1453300326158 0.23826714801444 9.2 9 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.288743273479686 0.472204745350415 1.14450367617091 0.238095238095238 9.2 9 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.196025760960885 0.363400233774003 1.13847997261212 0.236842105263158 9.2 9 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.196025760960885 0.363400233774003 1.13847997261212 0.236842105263158 9.2 9 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.103034831182016 0.227381843656398 1.13496614553616 0.236111111111111 9.2 9 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.103034831182016 0.227381843656398 1.13496614553616 0.236111111111111 9.2 9 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.220655472163571 0.393968302244368 1.13103892703949 0.235294117647059 9.2 9 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.063677333044184 0.163856862426535 1.12311108409295 0.233644859813084 9.2 9 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.249513279840431 0.431943305611841 1.1216136026475 0.233333333333333 9.2 9 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.113767916895473 0.245290523851906 1.11941866409045 0.232876712328767 9.2 9 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0217867503053769 0.0692021109030164 1.11728304819712 0.232432432432432 9.2 9 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.0768319415269189 0.184580077245691 1.11675813250616 0.232323232323232 9.2 9 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.125807338162316 0.264655698688447 1.11464705853167 0.231884057971014 9.2 9 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0766361929511011 0.184580077245691 1.10928817844258 0.230769230769231 9.2 9 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.28378265410957 0.470107935736807 1.10928817844258 0.230769230769231 9.2 9 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.0043954366027279 0.0192452501097902 1.10588545396883 0.230061349693252 9.2 9 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.154435406561439 0.304710964538838 1.10322649440737 0.229508196721311 9.2 9 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.19297996859572 0.360381227443188 1.1015847883145 0.229166666666667 9.2 9 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.153096221951993 0.304268050052635 1.09248078179951 0.227272727272727 9.2 9 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.325227397409917 0.503041941863383 1.09248078179951 0.227272727272727 9.2 9 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.325227397409917 0.503041941863383 1.09248078179951 0.227272727272727 9.2 9 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 0.000195267324794116 0.00134023752709358 1.09146135960809 0.22706065318818 9.2 9 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.123259893512641 0.261010161411441 1.08727849236237 0.226190476190476 9.2 9 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.123259893512641 0.261010161411441 1.08727849236237 0.226190476190476 9.2 9 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.0749810231367391 0.184580077245691 1.08543251869112 0.225806451612903 9.2 9 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.0749810231367391 0.184580077245691 1.08543251869112 0.225806451612903 9.2 9 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.0749810231367391 0.184580077245691 1.08543251869112 0.225806451612903 9.2 9 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.27810434398527 0.46231598305028 1.08543251869112 0.225806451612903 9.2 9 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.0469787567083808 0.126851557487715 1.08448701998146 0.225609756097561 9.2 9 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.0906144326769378 0.208310723262169 1.08263861259411 0.225225225225225 9.2 9 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.241891852347405 0.419259568684966 1.08155597398151 0.225 9.2 9 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.241891852347405 0.419259568684966 1.08155597398151 0.225 9.2 9 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 1.72317442425892e-10 7.21199178153072e-09 1.08096976478152 0.224878048780488 9.2 9 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.038521225492908 0.110352765233722 1.07654877039827 0.223958333333333 9.2 9 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.209277963704881 0.376965243483603 1.06820343109285 0.222222222222222 9.2 9 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.237547918654258 0.417637963246065 1.06820343109285 0.222222222222222 9.2 9 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.237547918654258 0.417637963246065 1.06820343109285 0.222222222222222 9.2 9 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.316208564311884 0.490692243201538 1.06820343109285 0.222222222222222 9.2 9 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.0871649491307216 0.200705052771872 1.06412631876044 0.221374045801527 9.2 9 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.0871649491307216 0.200705052771872 1.06412631876044 0.221374045801527 9.2 9 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0278946612929276 0.0853449646833932 1.06176847066458 0.220883534136546 9.2 9 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00333529278515446 0.0153596169361644 1.05849249081019 0.22020202020202 9.2 9 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.233064464211916 0.414045858393953 1.05752139678192 0.22 9.2 9 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.0940635778429984 0.213480815423583 1.05606475573952 0.21969696969697 9.2 9 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0693941433727261 0.174774984105114 1.05517655998196 0.219512195121951 9.2 9 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 0.0466357018728973 0.126164645941317 1.05294338207724 0.219047619047619 9.2 9 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.307453708645882 0.488985953644847 1.05151275248203 0.21875 9.2 9 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.198608195249344 0.367038262129632 1.04498161737344 0.217391304347826 9.2 9 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.260109816092025 0.4438084751786 1.04498161737344 0.217391304347826 9.2 9 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.362141628360308 0.546476709604156 1.04498161737344 0.217391304347826 9.2 9 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.21504564175867 0.38491817386489 1.03005330855382 0.214285714285714 9.2 9 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.138576279208096 0.282390830665453 1.02194265258096 0.21259842519685 9.2 9 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.307107623431738 0.488985953644847 1.00144071664955 0.208333333333333 9.2 9 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.399133399259801 0.596603810028042 1.00144071664955 0.208333333333333 9.2 9 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.399133399259801 0.596603810028042 1.00144071664955 0.208333333333333 9.2 9 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.298312385112361 0.481837144171272 0.997661695077287 0.207547169811321 9.2 9 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.382352968411394 0.575754787353876 0.994534228948518 0.206896551724138 9.2 9 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.254372908589595 0.434540995105635 0.98454894552534 0.204819277108434 9.2 9 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.278490758037616 0.462418143159309 0.973552494160574 0.20253164556962 9.2 9 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.273678101808466 0.46039281098907 0.961383087983567 0.2 9.2 9 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.273678101808466 0.46039281098907 0.961383087983567 0.2 9.2 9 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.415562890554135 0.609007202120015 0.961383087983567 0.2 9.2 9 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.415562890554135 0.609007202120015 0.961383087983567 0.2 9.2 9 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.190590793986593 0.358367643093575 0.956214361704086 0.198924731182796 9.2 9 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.306134435250917 0.488985953644847 0.950204214867479 0.197674418604651 9.2 9 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.32413270020585 0.502440993892074 0.948733310510099 0.197368421052632 9.2 9 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.283220507332737 0.469723522068163 0.944215532841003 0.196428571428571 9.2 9 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.175442065851281 0.335106120411239 0.942532439199576 0.196078431372549 9.2 9 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.410750194407205 0.605903147762714 0.937934719983968 0.195121951219512 9.2 9 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.306316562167332 0.488985953644847 0.934678002206246 0.194444444444444 9.2 9 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.354307275811981 0.535222137452706 0.934678002206246 0.194444444444444 9.2 9 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.448552941730662 0.634483932487805 0.930370730306678 0.193548387096774 9.2 9 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.472094030508068 0.663776265285209 0.924406815368815 0.192307692307692 9.2 9 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.472094030508068 0.663776265285209 0.924406815368815 0.192307692307692 9.2 9 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.421421153927098 0.615690248499241 0.920473169345969 0.191489361702128 9.2 9 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.438924177797539 0.62646851053751 0.915602940936731 0.19047619047619 9.2 9 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.408872146855367 0.605903147762714 0.905650735056984 0.188405797101449 9.2 9 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.447801199426028 0.634050852520635 0.901296644984594 0.1875 9.2 9 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.488421716553591 0.680728797899864 0.885484423142759 0.184210526315789 9.2 9 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.513060364826702 0.71019931823774 0.873984625439607 0.181818181818182 9.2 9 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.513060364826702 0.71019931823774 0.873984625439607 0.181818181818182 9.2 9 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.454196508947888 0.641828830419905 0.86933577104897 0.180851063829787 9.2 9 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.472951544491084 0.663776265285209 0.860184868195823 0.178947368421053 9.2 9 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.521826584427972 0.714821724124218 0.854562744874282 0.177777777777778 9.2 9 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.54422766064695 0.726487768387064 0.848279195279618 0.176470588235294 9.2 9 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.54422766064695 0.726487768387064 0.848279195279618 0.176470588235294 9.2 9 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.54422766064695 0.726487768387064 0.848279195279618 0.176470588235294 9.2 9 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.54853147294227 0.731546659790862 0.835985293898754 0.173913043478261 9.2 9 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.550565982421315 0.732886242268972 0.831966133831933 0.173076923076923 9.2 9 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.550565982421315 0.732886242268972 0.831966133831933 0.173076923076923 9.2 9 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.552529491025191 0.733441665791835 0.828778524123765 0.172413793103448 9.2 9 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.552529491025191 0.733441665791835 0.828778524123765 0.172413793103448 9.2 9 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.552529491025191 0.733441665791835 0.828778524123765 0.172413793103448 9.2 9 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.554729536731633 0.735675797548103 0.819612310032073 0.170506912442396 9.2 9 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.599966221556944 0.785420361799017 0.801152573319639 0.166666666666667 9.2 9 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.599966221556944 0.785420361799017 0.801152573319639 0.166666666666667 9.2 9 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.607127871636407 0.78655162382602 0.801152573319639 0.166666666666667 9.2 9 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.601438087541926 0.78655162382602 0.801152573319639 0.166666666666667 9.2 9 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.66889799661053 0.846081643712697 0.792893268440056 0.164948453608247 9.2 9 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.662003329317249 0.838105638450574 0.78970753655793 0.164285714285714 9.2 9 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.62454372833544 0.800653806685884 0.784802520802912 0.163265306122449 9.2 9 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.627596022422299 0.803842610177256 0.782521118126159 0.162790697674419 9.2 9 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.637623050464435 0.812874003538061 0.775308941922232 0.161290322580645 9.2 9 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.653608846571093 0.828214949840307 0.773526622515514 0.160919540229885 9.2 9 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.671041974060751 0.84665275830067 0.764736547259656 0.159090909090909 9.2 9 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.685556805196925 0.852751165904917 0.758986648408079 0.157894736842105 9.2 9 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.723016987144192 0.887707655484197 0.75580431445249 0.157232704402516 9.2 9 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.723016987144192 0.887707655484197 0.75580431445249 0.157232704402516 9.2 9 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.697809193068478 0.865721431330814 0.744733378015439 0.154929577464789 9.2 9 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.717006797898708 0.887707655484197 0.743337439162552 0.154639175257732 9.2 9 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.79713721501345 0.954017036975727 0.732017579682919 0.152284263959391 9.2 9 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.72819220827986 0.893290958950208 0.730164370620431 0.151898734177215 9.2 9 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.831836468226742 0.981511852642333 0.71011250816968 0.147727272727273 9.2 9 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.744081519892364 0.9049811989802 0.686702205702548 0.142857142857143 9.2 9 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.753302917839531 0.915414220397653 0.686702205702548 0.142857142857143 9.2 9 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.762339931506838 0.920891105716664 0.686702205702548 0.142857142857143 9.2 9 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.864126919141695 1 0.686702205702548 0.142857142857143 9.2 9 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.871482481532123 1 0.682463303198211 0.141975308641975 9.2 9 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.853207407519154 1 0.667627144433033 0.138888888888889 9.2 9 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.787812185042047 0.94524177007996 0.649583167556464 0.135135135135135 9.2 9 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.920464656081434 1 0.631565532251979 0.131386861313869 9.2 9 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.846957737478276 0.995936596035182 0.630415139661356 0.131147540983607 9.2 9 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.900409128994338 1 0.628942207092053 0.130841121495327 9.2 9 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.827217123441344 0.978495400379911 0.626988970424066 0.130434782608696 9.2 9 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.941876803177413 1 0.620247153537785 0.129032258064516 9.2 9 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.935417762302749 1 0.618031985132293 0.128571428571429 9.2 9 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.939841599836198 1 0.613648779563979 0.127659574468085 9.2 9 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.944004730265722 1 0.609327309285359 0.126760563380282 9.2 9 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.951069835700042 1 0.59647855823798 0.124087591240876 9.2 9 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.90988891872673 1 0.59344635060714 0.123456790123457 9.2 9 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.967191421285801 1 0.589805575450041 0.122699386503067 9.2 9 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.969297080986618 1 0.565519463519745 0.117647058823529 9.2 9 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.99999998452167 1 0.556972569864535 0.115869017632242 9.2 9 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.929570073371957 1 0.524390775263764 0.109090909090909 9.2 9 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999999998669 1 0.478083814096711 0.0994575045207957 9.2 9 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.997009253165947 1 0.373871200882498 0.0777777777777778 9.2 9 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 3.32556722912793e-05 0.000156180929605579 2.62784728905999 1 9.3 9 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 3.32556722912793e-05 0.000156180929605579 2.62784728905999 1 9.3 9 3 ERK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604939 ERK ACTIVATION 0.00159007835901825 0.00494035263074884 2.62784728905999 1 9.3 9 3 SYNTHESIS OF GDP-MANNOSE%REACTOME%REACT_198715.2 SYNTHESIS OF GDP-MANNOSE 0.00159007835901825 0.00494035263074884 2.62784728905999 1 9.3 9 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00159007835901825 0.00494035263074884 2.62784728905999 1 9.3 9 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 1.45161271244591e-08 1.7071445370335e-07 2.62784728905999 1 9.3 9 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.000120711968868078 0.000499340499125799 2.62784728905999 1 9.3 9 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 1.85589359583255e-06 1.18427649635413e-05 2.42570518990153 0.923076923076923 9.3 9 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 6.23484546630918e-06 3.66619218948676e-05 2.40886001497166 0.916666666666667 9.3 9 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 2.08075997587442e-05 0.000105747194488189 2.38895208096363 0.909090909090909 9.3 9 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 2.08075997587442e-05 0.000105747194488189 2.38895208096363 0.909090909090909 9.3 9 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 6.88998728090304e-05 0.000300750058304449 2.36506256015399 0.9 9.3 9 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 6.88998728090304e-05 0.000300750058304449 2.36506256015399 0.9 9.3 9 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000226012279252857 0.000873955090697868 2.33586425694222 0.888888888888889 9.3 9 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.000226012279252857 0.000873955090697868 2.33586425694222 0.888888888888889 9.3 9 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000732906044905669 0.00250784057448958 2.29936637792749 0.875 9.3 9 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000732906044905669 0.00250784057448958 2.29936637792749 0.875 9.3 9 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 9.69541965099563e-06 5.41042437779089e-05 2.25244053347999 0.857142857142857 9.3 9 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 9.69541965099563e-06 5.41042437779089e-05 2.25244053347999 0.857142857142857 9.3 9 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00234262598459488 0.00705873150016707 2.25244053347999 0.857142857142857 9.3 9 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.00234262598459488 0.00705873150016707 2.25244053347999 0.857142857142857 9.3 9 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 3.03190807539305e-05 0.000145266168056711 2.22356309074307 0.846153846153846 9.3 9 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 3.03190807539305e-05 0.000145266168056711 2.22356309074307 0.846153846153846 9.3 9 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 4.34219307120565e-07 3.26928081498711e-06 2.21292403289263 0.842105263157895 9.3 9 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.06293584045777e-10 5.81141026796188e-09 2.18987274088333 0.833333333333333 9.3 9 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 9.36713712209198e-05 0.000393198705744451 2.18987274088333 0.833333333333333 9.3 9 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 9.36713712209198e-05 0.000393198705744451 2.18987274088333 0.833333333333333 9.3 9 3 PHOSPHORYLATION OF EMI1%REACTOME%REACT_204224.1 PHOSPHORYLATION OF EMI1 0.00734982886996423 0.018878712061298 2.18987274088333 0.833333333333333 9.3 9 3 RAF PHOSPHORYLATES MEK%REACTOME DATABASE ID RELEASE 48%5604937 RAF PHOSPHORYLATES MEK 0.00734982886996423 0.018878712061298 2.18987274088333 0.833333333333333 9.3 9 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00734982886996423 0.018878712061298 2.18987274088333 0.833333333333333 9.3 9 3 MEK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604936 MEK ACTIVATION 0.00734982886996423 0.018878712061298 2.18987274088333 0.833333333333333 9.3 9 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 4.05541636459357e-06 2.47676286987839e-05 2.16410953216705 0.823529411764706 9.3 9 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.000285315101535319 0.00105730049344989 2.15005687286727 0.818181818181818 9.3 9 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.000285315101535319 0.00105730049344989 2.15005687286727 0.818181818181818 9.3 9 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.000285315101535319 0.00105730049344989 2.15005687286727 0.818181818181818 9.3 9 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 1.2194333922866e-05 6.54812723480694e-05 2.13512592236125 0.8125 9.3 9 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 1.2194333922866e-05 6.54812723480694e-05 2.13512592236125 0.8125 9.3 9 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 7.36464245568286e-08 6.20111610321699e-07 2.10227783124799 0.8 9.3 9 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 1.61061869413867e-06 1.04653443002709e-05 2.10227783124799 0.8 9.3 9 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00085446190502816 0.00286011793036665 2.10227783124799 0.8 9.3 9 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.000105939171464692 0.00044208633722656 2.06473715568999 0.785714285714286 9.3 9 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00250703422469051 0.00742599616058759 2.04388122482444 0.777777777777778 9.3 9 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.00250703422469051 0.00742599616058759 2.04388122482444 0.777777777777778 9.3 9 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 2.35831728151249e-07 1.83170014204783e-06 2.02142099158461 0.769230769230769 9.3 9 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 2.35831728151249e-07 1.83170014204783e-06 2.02142099158461 0.769230769230769 9.3 9 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00030484567277755 0.00111229587785245 2.02142099158461 0.769230769230769 9.3 9 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 3.16045357508704e-08 3.43307285293806e-07 2.01468292161266 0.766666666666667 9.3 9 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 6.62793403398155e-07 4.53439910113257e-06 1.9971639396856 0.76 9.3 9 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 1.8413979367945e-06 1.18031948831467e-05 1.970885466795 0.75 9.3 9 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.000860246292478516 0.00286011793036665 1.970885466795 0.75 9.3 9 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000860246292478516 0.00286011793036665 1.970885466795 0.75 9.3 9 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.000860246292478516 0.00286011793036665 1.970885466795 0.75 9.3 9 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.000860246292478516 0.00286011793036665 1.970885466795 0.75 9.3 9 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0071717858036625 0.0185891642961962 1.970885466795 0.75 9.3 9 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0071717858036625 0.0185891642961962 1.970885466795 0.75 9.3 9 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0071717858036625 0.0185891642961962 1.970885466795 0.75 9.3 9 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.0071717858036625 0.0185891642961962 1.970885466795 0.75 9.3 9 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0071717858036625 0.0185891642961962 1.970885466795 0.75 9.3 9 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.0071717858036625 0.0185891642961962 1.970885466795 0.75 9.3 9 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0071717858036625 0.0185891642961962 1.970885466795 0.75 9.3 9 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.39940619416313e-05 7.3481734844802e-05 1.970885466795 0.75 9.3 9 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 1.39940619416313e-05 7.3481734844802e-05 1.970885466795 0.75 9.3 9 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 6.72412753532043e-07 4.57819783864161e-06 1.94655354745185 0.740740740740741 9.3 9 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 5.05181364941523e-06 3.00783716448447e-05 1.94232190930521 0.739130434782609 9.3 9 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.000297710026689462 0.00108905235984345 1.92708801197733 0.733333333333333 9.3 9 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.000297710026689462 0.00108905235984345 1.92708801197733 0.733333333333333 9.3 9 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 2.28081204813024e-10 4.57126133026666e-09 1.92708801197733 0.733333333333333 9.3 9 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 1.21433021822749e-08 1.48964819011873e-07 1.91761829201675 0.72972972972973 9.3 9 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 6.10840837528314e-10 9.24709055109352e-09 1.9111616647709 0.727272727272727 9.3 9 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 1.36692988139454e-05 7.23100825733991e-05 1.9111616647709 0.727272727272727 9.3 9 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00237218671434241 0.00709164221535556 1.9111616647709 0.727272727272727 9.3 9 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.44132610917012e-09 5.74546095759007e-08 1.9051892845685 0.725 9.3 9 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 6.56818357265833e-07 4.51522957675981e-06 1.90292389897448 0.724137931034483 9.3 9 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.000103812712901034 0.00043448673664168 1.89788970876555 0.722222222222222 9.3 9 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 1.74026660371282e-06 1.1205427045626e-05 1.8770337779 0.714285714285714 9.3 9 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 3.64277300710851e-05 0.0001697498635451 1.8770337779 0.714285714285714 9.3 9 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.000802111926059695 0.00270475182649987 1.8770337779 0.714285714285714 9.3 9 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.000802111926059695 0.00270475182649987 1.8770337779 0.714285714285714 9.3 9 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.000802111926059695 0.00270475182649987 1.8770337779 0.714285714285714 9.3 9 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0198678360833876 0.0444527212997808 1.8770337779 0.714285714285714 9.3 9 3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0198678360833876 0.0444527212997808 1.8770337779 0.714285714285714 9.3 9 3 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0198678360833876 0.0444527212997808 1.8770337779 0.714285714285714 9.3 9 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0198678360833876 0.0444527212997808 1.8770337779 0.714285714285714 9.3 9 3 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0198678360833876 0.0444527212997808 1.8770337779 0.714285714285714 9.3 9 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0198678360833876 0.0444527212997808 1.8770337779 0.714285714285714 9.3 9 3 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0198678360833876 0.0444527212997808 1.8770337779 0.714285714285714 9.3 9 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 1.28485375229228e-05 6.87348454703727e-05 1.86139182975083 0.708333333333333 9.3 9 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 2.2334481998034e-07 1.75590982780123e-06 1.85495102757176 0.705882352941177 9.3 9 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 2.2334481998034e-07 1.75590982780123e-06 1.85495102757176 0.705882352941177 9.3 9 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000275246519880133 0.00103344537675311 1.85495102757176 0.705882352941177 9.3 9 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000275246519880133 0.00103344537675311 1.85495102757176 0.705882352941177 9.3 9 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.000275246519880133 0.00103344537675311 1.85495102757176 0.705882352941177 9.3 9 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.000275246519880133 0.00103344537675311 1.85495102757176 0.705882352941177 9.3 9 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.000275246519880133 0.00103344537675311 1.85495102757176 0.705882352941177 9.3 9 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.000275246519880133 0.00103344537675311 1.85495102757176 0.705882352941177 9.3 9 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 4.55122136471699e-06 2.72117142940852e-05 1.84922587007925 0.703703703703704 9.3 9 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.46063721359876e-09 2.09948157065761e-08 1.8450842667868 0.702127659574468 9.3 9 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00636303630390265 0.0170841521895349 1.839493102342 0.7 9.3 9 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00636303630390265 0.0170841521895349 1.839493102342 0.7 9.3 9 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00636303630390265 0.0170841521895349 1.839493102342 0.7 9.3 9 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00636303630390265 0.0170841521895349 1.839493102342 0.7 9.3 9 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 5.76866523785153e-07 4.00429786998182e-06 1.83152992873878 0.696969696969697 9.3 9 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 3.74842523465252e-09 4.93889732306531e-08 1.82806767934608 0.695652173913043 9.3 9 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.06211201941519e-07 1.63932145454068e-06 1.82489395073611 0.694444444444444 9.3 9 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.06211201941519e-07 1.63932145454068e-06 1.82489395073611 0.694444444444444 9.3 9 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 1.17355086493478e-05 6.34966874829733e-05 1.81927889242615 0.692307692307692 9.3 9 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 1.17355086493478e-05 6.34966874829733e-05 1.81927889242615 0.692307692307692 9.3 9 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 1.17355086493478e-05 6.34966874829733e-05 1.81927889242615 0.692307692307692 9.3 9 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00210989768680569 0.00644288499640449 1.81927889242615 0.692307692307692 9.3 9 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.00210989768680569 0.00644288499640449 1.81927889242615 0.692307692307692 9.3 9 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.000714556717127165 0.00246201987523476 1.80664501122875 0.6875 9.3 9 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000714556717127165 0.00246201987523476 1.80664501122875 0.6875 9.3 9 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.000714556717127165 0.00246201987523476 1.80664501122875 0.6875 9.3 9 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.000714556717127165 0.00246201987523476 1.80664501122875 0.6875 9.3 9 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000714556717127165 0.00246201987523476 1.80664501122875 0.6875 9.3 9 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000714556717127165 0.00246201987523476 1.80664501122875 0.6875 9.3 9 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 2.10862161260916e-14 9.0926319840692e-13 1.80664501122875 0.6875 9.3 9 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 1.23746727861784e-09 1.79685299742162e-08 1.80342461013921 0.686274509803922 9.3 9 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 5.24104270086575e-07 3.65588419771175e-06 1.801952426784 0.685714285714286 9.3 9 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000245470855121685 0.000941522983391262 1.79800077672526 0.684210526315789 9.3 9 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.000245470855121685 0.000941522983391262 1.79800077672526 0.684210526315789 9.3 9 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.000245470855121685 0.000941522983391262 1.79800077672526 0.684210526315789 9.3 9 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.83460755124908e-11 1.34822829429749e-09 1.79569564752433 0.683333333333333 9.3 9 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.83460755124908e-11 1.34822829429749e-09 1.79569564752433 0.683333333333333 9.3 9 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.83460755124908e-11 1.34822829429749e-09 1.79569564752433 0.683333333333333 9.3 9 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.83460755124908e-11 1.34822829429749e-09 1.79569564752433 0.683333333333333 9.3 9 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.83460755124908e-11 1.34822829429749e-09 1.79569564752433 0.683333333333333 9.3 9 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.83460755124908e-11 1.34822829429749e-09 1.79569564752433 0.683333333333333 9.3 9 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.83460755124908e-11 1.34822829429749e-09 1.79569564752433 0.683333333333333 9.3 9 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 6.6973969153264e-08 5.76581481917071e-07 1.79462741691902 0.682926829268293 9.3 9 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 6.6973969153264e-08 5.76581481917071e-07 1.79462741691902 0.682926829268293 9.3 9 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 8.51957970506699e-05 0.000362974907793722 1.79171406072272 0.681818181818182 9.3 9 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 8.51957970506699e-05 0.000362974907793722 1.79171406072272 0.681818181818182 9.3 9 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.97984772288153e-05 0.000143817713298892 1.7869361565608 0.68 9.3 9 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.97984772288153e-05 0.000143817713298892 1.7869361565608 0.68 9.3 9 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 1.04854591935036e-05 5.78325908230838e-05 1.783182089005 0.678571428571429 9.3 9 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.04854591935036e-05 5.78325908230838e-05 1.783182089005 0.678571428571429 9.3 9 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 3.70744561539585e-06 2.28385069727632e-05 1.78015461516967 0.67741935483871 9.3 9 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4.68692491476659e-07 3.42483635889225e-06 1.7755724926081 0.675675675675676 9.3 9 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 3.6114689986769e-10 5.92808583146508e-09 1.76700076333344 0.672413793103448 9.3 9 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 3.6114689986769e-10 5.92808583146508e-09 1.76700076333344 0.672413793103448 9.3 9 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 3.26221420271327e-06 2.0271313582799e-05 1.75189819270666 0.666666666666667 9.3 9 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00539606755807019 0.0148235601064361 1.75189819270666 0.666666666666667 9.3 9 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.000618114133838331 0.00217179361099246 1.75189819270666 0.666666666666667 9.3 9 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000618114133838331 0.00217179361099246 1.75189819270666 0.666666666666667 9.3 9 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000618114133838331 0.00217179361099246 1.75189819270666 0.666666666666667 9.3 9 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0165012889616065 0.0378121323548568 1.75189819270666 0.666666666666667 9.3 9 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0165012889616065 0.0378121323548568 1.75189819270666 0.666666666666667 9.3 9 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0165012889616065 0.0378121323548568 1.75189819270666 0.666666666666667 9.3 9 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.26707876165871e-20 4.16391837657797e-18 1.73842205276277 0.661538461538462 9.3 9 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 2.82210595419769e-10 5.42683347678825e-09 1.73776998147516 0.661290322580645 9.3 9 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 4.64062130184628e-08 4.26038975001758e-07 1.73326097789063 0.659574468085106 9.3 9 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.29309815476022e-07 1.05751647943896e-06 1.73199025869863 0.659090909090909 9.3 9 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.29309815476022e-07 1.05751647943896e-06 1.73199025869863 0.659090909090909 9.3 9 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 1.17265846908507e-11 3.47644375314179e-10 1.72789958732712 0.657534246575342 9.3 9 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.45108751503116e-08 1.7071445370335e-07 1.71820784284692 0.653846153846154 9.3 9 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 6.39174178789206e-05 0.00028072372111637 1.71820784284692 0.653846153846154 9.3 9 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 6.39174178789206e-05 0.00028072372111637 1.71820784284692 0.653846153846154 9.3 9 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 4.02944002028245e-08 3.89217802694575e-07 1.71614516836571 0.653061224489796 9.3 9 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00018237590196797 0.00072289946657499 1.71381344938695 0.652173913043478 9.3 9 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00018237590196797 0.00072289946657499 1.71381344938695 0.652173913043478 9.3 9 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 3.12108878586847e-07 2.38780072166174e-06 1.71115637427162 0.651162790697674 9.3 9 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.000524073657147348 0.00188322427808251 1.708100737889 0.65 9.3 9 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.000524073657147348 0.00188322427808251 1.708100737889 0.65 9.3 9 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 4.52709078498116e-09 5.80364881714252e-08 1.70579560868807 0.649122807017544 9.3 9 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00151995874541339 0.00480213158754945 1.70037177527411 0.647058823529412 9.3 9 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00151995874541339 0.00480213158754945 1.70037177527411 0.647058823529412 9.3 9 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.00151995874541339 0.00480213158754945 1.70037177527411 0.647058823529412 9.3 9 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.00151995874541339 0.00480213158754945 1.70037177527411 0.647058823529412 9.3 9 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.47263148525529e-08 3.71545458911148e-07 1.70037177527411 0.647058823529412 9.3 9 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 3.47263148525529e-08 3.71545458911148e-07 1.70037177527411 0.647058823529412 9.3 9 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.11203826791633e-10 7.90698962526624e-09 1.69799363293107 0.646153846153846 9.3 9 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00446391205614846 0.0123582623655628 1.68933040011 0.642857142857143 9.3 9 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00446391205614846 0.0123582623655628 1.68933040011 0.642857142857143 9.3 9 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00446391205614846 0.0123582623655628 1.68933040011 0.642857142857143 9.3 9 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00446391205614846 0.0123582623655628 1.68933040011 0.642857142857143 9.3 9 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00446391205614846 0.0123582623655628 1.68933040011 0.642857142857143 9.3 9 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 1.20837323392233e-09 1.78179707717726e-08 1.68346466955406 0.640625 9.3 9 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.000153697563366781 0.0006248903790598 1.6818222649984 0.64 9.3 9 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.05892102152137e-12 7.32461153406226e-11 1.68060001044534 0.63953488372093 9.3 9 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 5.79572262833188e-06 3.42212170129306e-05 1.67890243467722 0.638888888888889 9.3 9 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.38234306589615e-28 1.27651236379504e-25 1.67681684159066 0.638095238095238 9.3 9 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.74931640781347e-10 5.92808583146508e-09 1.67572870606724 0.63768115942029 9.3 9 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.28520763018926e-21 1.52404204813276e-19 1.67525264677575 0.6375 9.3 9 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 6.32007239030787e-07 4.36575874340199e-06 1.67226645667454 0.636363636363636 9.3 9 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0133470230856331 0.0315495246691958 1.67226645667454 0.636363636363636 9.3 9 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0133470230856331 0.0315495246691958 1.67226645667454 0.636363636363636 9.3 9 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0133470230856331 0.0315495246691958 1.67226645667454 0.636363636363636 9.3 9 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.99859502386623e-21 3.04785765640118e-19 1.66926148550352 0.635220125786163 9.3 9 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 4.55318962611501e-05 0.000201843889033074 1.66430328307133 0.633333333333333 9.3 9 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.44355520150778e-18 1.02708952587279e-16 1.66367310386532 0.633093525179856 9.3 9 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.61468580799726e-20 1.43606119048756e-18 1.65705020138178 0.630573248407643 9.3 9 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00012820008680145 0.000528778908749168 1.65457051533407 0.62962962962963 9.3 9 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00363818073758849 0.0103335951887992 1.6424045556625 0.625 9.3 9 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00363818073758849 0.0103335951887992 1.6424045556625 0.625 9.3 9 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00363818073758849 0.0103335951887992 1.6424045556625 0.625 9.3 9 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0410279198829294 0.0818832117719615 1.6424045556625 0.625 9.3 9 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.0410279198829294 0.0818832117719615 1.6424045556625 0.625 9.3 9 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0410279198829294 0.0818832117719615 1.6424045556625 0.625 9.3 9 3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0410279198829294 0.0818832117719615 1.6424045556625 0.625 9.3 9 3 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.0410279198829294 0.0818832117719615 1.6424045556625 0.625 9.3 9 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0410279198829294 0.0818832117719615 1.6424045556625 0.625 9.3 9 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.08265023791957e-06 2.48273986690579e-05 1.6424045556625 0.625 9.3 9 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.23214047336402e-06 8.23162391360092e-06 1.63510497985955 0.622222222222222 9.3 9 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00102874540934196 0.0033575796272789 1.62676260751333 0.619047619047619 9.3 9 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.16680170250566e-19 8.73873064560816e-18 1.62598051010587 0.61875 9.3 9 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.85847250517034e-17 1.69483598952391e-15 1.62586235150474 0.618705035971223 9.3 9 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 3.13954395534566e-05 0.000148424287324149 1.62308214912529 0.617647058823529 9.3 9 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000297345796147359 0.00108905235984345 1.61713679326769 0.615384615384615 9.3 9 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0106539393520934 0.0258712554573872 1.61713679326769 0.615384615384615 9.3 9 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0106539393520934 0.0258712554573872 1.61713679326769 0.615384615384615 9.3 9 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0106539393520934 0.0258712554573872 1.61713679326769 0.615384615384615 9.3 9 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.0106539393520934 0.0258712554573872 1.61713679326769 0.615384615384615 9.3 9 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 9.34918947699098e-11 2.07873384777471e-09 1.60762422389553 0.611764705882353 9.3 9 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 9.34918947699098e-11 2.07873384777471e-09 1.60762422389553 0.611764705882353 9.3 9 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00293714313503134 0.00861763851783422 1.60590667664777 0.611111111111111 9.3 9 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00293714313503134 0.00861763851783422 1.60590667664777 0.611111111111111 9.3 9 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00293714313503134 0.00861763851783422 1.60590667664777 0.611111111111111 9.3 9 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 2.52621293319695e-10 4.92438493690309e-09 1.60234590796341 0.609756097560976 9.3 9 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 7.71969067703623e-06 4.3765417663038e-05 1.60234590796341 0.609756097560976 9.3 9 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.000835765324905988 0.00281156987551116 1.59955921942782 0.608695652173913 9.3 9 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.25852167634432e-16 1.28555053817519e-14 1.595478711215 0.607142857142857 9.3 9 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 6.09131537869094e-12 1.92620928530605e-10 1.59263472064242 0.606060606060606 9.3 9 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 2.11826436563796e-05 0.000106889723131306 1.59053914864157 0.605263157894737 9.3 9 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.7307066242842e-10 3.56926887877743e-09 1.58893091896651 0.604651162790698 9.3 9 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 1.90622170973496e-06 1.21096138078252e-05 1.58765773714041 0.604166666666667 9.3 9 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 5.31526909088236e-08 4.8175973989335e-07 1.58505074578222 0.603174603174603 9.3 9 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.51694446422272e-09 2.15861197258892e-08 1.58344644340794 0.602564102564103 9.3 9 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.000196890519727882 0.000776108613775001 1.576708373436 0.6 9.3 9 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.000675284050409286 0.00236100541457596 1.576708373436 0.6 9.3 9 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.000675284050409286 0.00236100541457596 1.576708373436 0.6 9.3 9 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.00235621747194614 0.00705873150016707 1.576708373436 0.6 9.3 9 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00235621747194614 0.00705873150016707 1.576708373436 0.6 9.3 9 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00235621747194614 0.00705873150016707 1.576708373436 0.6 9.3 9 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00235621747194614 0.00705873150016707 1.576708373436 0.6 9.3 9 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00235621747194614 0.00705873150016707 1.576708373436 0.6 9.3 9 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.00844340655317091 0.0209319991727565 1.576708373436 0.6 9.3 9 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00844340655317091 0.0209319991727565 1.576708373436 0.6 9.3 9 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.00844340655317091 0.0209319991727565 1.576708373436 0.6 9.3 9 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.00844340655317091 0.0209319991727565 1.576708373436 0.6 9.3 9 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.00844340655317091 0.0209319991727565 1.576708373436 0.6 9.3 9 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00844340655317091 0.0209319991727565 1.576708373436 0.6 9.3 9 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00844340655317091 0.0209319991727565 1.576708373436 0.6 9.3 9 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0317086679481623 0.0650164762107131 1.576708373436 0.6 9.3 9 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0317086679481623 0.0650164762107131 1.576708373436 0.6 9.3 9 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0317086679481623 0.0650164762107131 1.576708373436 0.6 9.3 9 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0317086679481623 0.0650164762107131 1.576708373436 0.6 9.3 9 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0317086679481623 0.0650164762107131 1.576708373436 0.6 9.3 9 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0317086679481623 0.0650164762107131 1.576708373436 0.6 9.3 9 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0317086679481623 0.0650164762107131 1.576708373436 0.6 9.3 9 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 2.55899577926696e-14 1.07101499820497e-12 1.5725700312485 0.598425196850394 9.3 9 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 2.10591211483523e-14 9.0926319840692e-13 1.56856000974899 0.596899224806202 9.3 9 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 1.40770464994057e-05 7.36457248847586e-05 1.56419481491666 0.595238095238095 9.3 9 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000159230914276073 0.000641885526954253 1.56028432787937 0.59375 9.3 9 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.000159230914276073 0.000641885526954253 1.56028432787937 0.59375 9.3 9 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.000159230914276073 0.000641885526954253 1.56028432787937 0.59375 9.3 9 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00054337591883232 0.0019427736997447 1.55724283796148 0.592592592592593 9.3 9 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00054337591883232 0.0019427736997447 1.55724283796148 0.592592592592593 9.3 9 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.2447477666407e-09 3.10123890478613e-08 1.55724283796148 0.592592592592593 9.3 9 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.82758046585855e-16 1.54755653958335e-14 1.55596221062763 0.592105263157895 9.3 9 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 3.43968389066765e-06 2.12811746800872e-05 1.55525655883142 0.591836734693878 9.3 9 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.41577704741443e-10 2.96272167422166e-09 1.54904682302484 0.589473684210526 9.3 9 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.41577704741443e-10 2.96272167422166e-09 1.54904682302484 0.589473684210526 9.3 9 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 8.45896998661021e-07 5.73195918616492e-06 1.5485528667675 0.589285714285714 9.3 9 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.60021368853724e-10 7.19352096570165e-09 1.54751007022422 0.588888888888889 9.3 9 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.00666421215498151 0.0176595417067759 1.54579252297647 0.588235294117647 9.3 9 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 2.79220333153238e-06 1.74267778103973e-05 1.54579252297647 0.588235294117647 9.3 9 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.37828021551496e-14 6.3267507957348e-13 1.539167697878 0.585714285714286 9.3 9 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00149857175831707 0.00478131751588608 1.53291091861833 0.583333333333333 9.3 9 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00149857175831707 0.00478131751588608 1.53291091861833 0.583333333333333 9.3 9 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0244783608242212 0.0517573662003963 1.53291091861833 0.583333333333333 9.3 9 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0244783608242212 0.0517573662003963 1.53291091861833 0.583333333333333 9.3 9 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0244783608242212 0.0517573662003963 1.53291091861833 0.583333333333333 9.3 9 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0244783608242212 0.0517573662003963 1.53291091861833 0.583333333333333 9.3 9 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0244783608242212 0.0517573662003963 1.53291091861833 0.583333333333333 9.3 9 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.0244783608242212 0.0517573662003963 1.53291091861833 0.583333333333333 9.3 9 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0244783608242212 0.0517573662003963 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 4.21219547540158e-08 3.89217802694575e-07 1.53291091861833 0.583333333333333 9.3 9 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 1.37602878386408e-07 1.11890797682205e-06 1.52964245184089 0.582089552238806 9.3 9 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 1.1568493674295e-17 7.15737673848773e-16 1.52919926990497 0.581920903954802 9.3 9 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 2.48278739497601e-05 0.000122249358583075 1.52781819131395 0.581395348837209 9.3 9 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 4.46898543209409e-25 7.94920783733736e-23 1.52617284864638 0.580769230769231 9.3 9 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 6.22435612151072e-18 4.02602670950443e-16 1.52214105267956 0.579234972677596 9.3 9 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0052474345689825 0.0144431322856133 1.52138527261368 0.578947368421053 9.3 9 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00119065439713009 0.00382460769100705 1.51606574368846 0.576923076923077 9.3 9 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00119065439713009 0.00382460769100705 1.51606574368846 0.576923076923077 9.3 9 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.36846680349122e-07 1.83170014204783e-06 1.50714770990206 0.573529411764706 9.3 9 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 3.60648173241664e-12 1.16636897846111e-10 1.50465449615532 0.57258064516129 9.3 9 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 3.60648173241664e-12 1.16636897846111e-10 1.50465449615532 0.57258064516129 9.3 9 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 3.60648173241664e-12 1.16636897846111e-10 1.50465449615532 0.57258064516129 9.3 9 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000944494947511053 0.00311836730929983 1.50162702232 0.571428571428571 9.3 9 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000944494947511053 0.00311836730929983 1.50162702232 0.571428571428571 9.3 9 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.01890730908002 0.0429108466042558 1.50162702232 0.571428571428571 9.3 9 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.00412618022208507 0.0115635190259022 1.50162702232 0.571428571428571 9.3 9 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00412618022208507 0.0115635190259022 1.50162702232 0.571428571428571 9.3 9 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00412618022208507 0.0115635190259022 1.50162702232 0.571428571428571 9.3 9 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 9.49105634948580e-09 1.17441505959289e-07 1.49726182748767 0.569767441860465 9.3 9 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.56414334617886e-20 2.14633881271325e-18 1.49657670722251 0.569506726457399 9.3 9 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.19833423641547e-10 2.58368124002912e-09 1.4947388249699 0.568807339449541 9.3 9 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 7.64388226012158e-09 9.54144250539737e-08 1.49309505060227 0.568181818181818 9.3 9 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 9.66070487542694e-11 2.11495123657424e-09 1.49148089379081 0.567567567567568 9.3 9 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.55270569138884e-23 5.05550019884632e-21 1.49012030184245 0.567049808429119 9.3 9 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 9.29376300343967e-26 1.88928925055638e-23 1.48881450506471 0.566552901023891 9.3 9 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 8.24806304274029e-06 4.65753718643628e-05 1.4874607296566 0.566037735849057 9.3 9 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 3.99926697210094e-07 3.02710473473385e-06 1.48530498946869 0.565217391304348 9.3 9 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 3.39001553879346e-05 0.000158683951042865 1.48530498946869 0.565217391304348 9.3 9 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00324204085489841 0.0094151512990213 1.48530498946869 0.565217391304348 9.3 9 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.49640952863713e-10 4.92438493690309e-09 1.48424707993203 0.564814814814815 9.3 9 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.32989980887945e-36 1.23228948560709e-33 1.48047734594929 0.563380281690141 9.3 9 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 3.20676219468501e-07 2.44022599092875e-06 1.48047734594929 0.563380281690141 9.3 9 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.59179881262163e-08 1.85666369701686e-07 1.48005192142459 0.563218390804598 9.3 9 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 1.29690489291629e-06 8.62381150756954e-06 1.47816410009625 0.5625 9.3 9 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0146215540303484 0.0340531446566051 1.47816410009625 0.5625 9.3 9 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0146215540303484 0.0340531446566051 1.47816410009625 0.5625 9.3 9 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0146215540303484 0.0340531446566051 1.47816410009625 0.5625 9.3 9 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0146215540303484 0.0340531446566051 1.47816410009625 0.5625 9.3 9 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0146215540303484 0.0340531446566051 1.47816410009625 0.5625 9.3 9 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.0146215540303484 0.0340531446566051 1.47816410009625 0.5625 9.3 9 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0146215540303484 0.0340531446566051 1.47816410009625 0.5625 9.3 9 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0146215540303484 0.0340531446566051 1.47816410009625 0.5625 9.3 9 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.27764708878043e-08 1.54075576892758e-07 1.4763187017191 0.561797752808989 9.3 9 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.6225841088879e-11 7.61619834070915e-10 1.47415823532634 0.560975609756098 9.3 9 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 2.15553300581187e-05 0.000108385988242767 1.4715944818736 0.56 9.3 9 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.69392576223514e-42 8.03485453220201e-40 1.4638008663395 0.557034220532319 9.3 9 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 2.6313659599002e-08 2.9253388757328e-07 1.46323314959022 0.556818181818182 9.3 9 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 8.74233016740218e-12 2.70442083222028e-10 1.46211052173263 0.556390977443609 9.3 9 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.05352837861526e-07 8.81865225158541e-07 1.45991516058889 0.555555555555556 9.3 9 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 2.67954714279089e-06 1.67973373752927e-05 1.45991516058889 0.555555555555556 9.3 9 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0019997524950023 0.00614610756023386 1.45991516058889 0.555555555555556 9.3 9 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 7.05767057697338e-05 0.000305260341368788 1.45991516058889 0.555555555555556 9.3 9 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0113230484299192 0.0272173951279984 1.45991516058889 0.555555555555556 9.3 9 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.0113230484299192 0.0272173951279984 1.45991516058889 0.555555555555556 9.3 9 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.0716862085345831 0.130280299801675 1.45991516058889 0.555555555555556 9.3 9 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0716862085345831 0.130280299801675 1.45991516058889 0.555555555555556 9.3 9 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0716862085345831 0.130280299801675 1.45991516058889 0.555555555555556 9.3 9 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.0716862085345831 0.130280299801675 1.45991516058889 0.555555555555556 9.3 9 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0716862085345831 0.130280299801675 1.45991516058889 0.555555555555556 9.3 9 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0716862085345831 0.130280299801675 1.45991516058889 0.555555555555556 9.3 9 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0716862085345831 0.130280299801675 1.45991516058889 0.555555555555556 9.3 9 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0716862085345831 0.130280299801675 1.45991516058889 0.555555555555556 9.3 9 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 6.72746894811076e-08 5.76581481917071e-07 1.45304497159788 0.552941176470588 9.3 9 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 6.72746894811076e-08 5.76581481917071e-07 1.45304497159788 0.552941176470588 9.3 9 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 6.72746894811076e-08 5.76581481917071e-07 1.45304497159788 0.552941176470588 9.3 9 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 6.72746894811076e-08 5.76581481917071e-07 1.45304497159788 0.552941176470588 9.3 9 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 6.72746894811076e-08 5.76581481917071e-07 1.45304497159788 0.552941176470588 9.3 9 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000293002748727944 0.00108016298300483 1.45223139658579 0.552631578947368 9.3 9 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000293002748727944 0.00108016298300483 1.45223139658579 0.552631578947368 9.3 9 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00157051109866707 0.00491173031517194 1.44984678017103 0.551724137931034 9.3 9 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 7.64259105438467e-22 9.88673370035399e-20 1.44918049029044 0.551470588235294 9.3 9 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.00878114435424911 0.0216936951668342 1.445316008983 0.55 9.3 9 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00878114435424911 0.0216936951668342 1.445316008983 0.55 9.3 9 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.60171648006516e-07 5.77369931657204e-06 1.4399163227726 0.547945205479452 9.3 9 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 2.17916102819187e-08 2.46106836755319e-07 1.43840062138021 0.547368421052632 9.3 9 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.87961713164533e-14 3.20362719380894e-12 1.43758704636811 0.547058823529412 9.3 9 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.3856110037149e-08 1.65691130948428e-07 1.43337124857818 0.545454545454545 9.3 9 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.000969121194948842 0.00318489482774181 1.43337124857818 0.545454545454545 9.3 9 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0068192299960952 0.0179036241410396 1.43337124857818 0.545454545454545 9.3 9 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0068192299960952 0.0179036241410396 1.43337124857818 0.545454545454545 9.3 9 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0068192299960952 0.0179036241410396 1.43337124857818 0.545454545454545 9.3 9 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0068192299960952 0.0179036241410396 1.43337124857818 0.545454545454545 9.3 9 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0068192299960952 0.0179036241410396 1.43337124857818 0.545454545454545 9.3 9 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0537426417831973 0.103206179834669 1.43337124857818 0.545454545454545 9.3 9 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0537426417831973 0.103206179834669 1.43337124857818 0.545454545454545 9.3 9 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0537426417831973 0.103206179834669 1.43337124857818 0.545454545454545 9.3 9 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0537426417831973 0.103206179834669 1.43337124857818 0.545454545454545 9.3 9 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0537426417831973 0.103206179834669 1.43337124857818 0.545454545454545 9.3 9 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0537426417831973 0.103206179834669 1.43337124857818 0.545454545454545 9.3 9 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0537426417831973 0.103206179834669 1.43337124857818 0.545454545454545 9.3 9 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.57893073207031e-13 6.24116231037792e-12 1.43054408635219 0.544378698224852 9.3 9 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 5.49440987659903e-08 4.94844636354457e-07 1.42817787448913 0.543478260869565 9.3 9 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.000114239265748066 0.000473943076266759 1.42817787448913 0.543478260869565 9.3 9 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000761550299094149 0.00258636294895221 1.426545671204 0.542857142857143 9.3 9 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000761550299094149 0.00258636294895221 1.426545671204 0.542857142857143 9.3 9 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 9.02582668691938e-05 0.000382254505222806 1.42341728157416 0.541666666666667 9.3 9 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.10345697394772e-05 6.03930489972154e-05 1.4216223039177 0.540983606557377 9.3 9 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.10345697394772e-05 6.03930489972154e-05 1.4216223039177 0.540983606557377 9.3 9 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.7714951090816e-08 3.05723840327374e-07 1.42118271755285 0.540816326530612 9.3 9 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.000598601820558357 0.00211893132003617 1.42045799408648 0.540540540540541 9.3 9 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.000598601820558357 0.00211893132003617 1.42045799408648 0.540540540540541 9.3 9 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.20550180403512e-08 2.47120398987557e-07 1.4190375360924 0.54 9.3 9 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 8.74416659187048e-06 4.91816168388605e-05 1.41820329885777 0.53968253968254 9.3 9 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.97155474272839e-11 8.457044797805e-10 1.41499469410923 0.538461538461538 9.3 9 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 5.63443425194407e-05 0.000248999998152684 1.41499469410923 0.538461538461538 9.3 9 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00412808690453852 0.0115635190259022 1.41499469410923 0.538461538461538 9.3 9 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00412808690453852 0.0115635190259022 1.41499469410923 0.538461538461538 9.3 9 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0406068525417036 0.0817306239983653 1.41499469410923 0.538461538461538 9.3 9 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.0406068525417036 0.0817306239983653 1.41499469410923 0.538461538461538 9.3 9 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.0406068525417036 0.0817306239983653 1.41499469410923 0.538461538461538 9.3 9 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0406068525417036 0.0817306239983653 1.41499469410923 0.538461538461538 9.3 9 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 7.02486427986972e-09 8.84635563739346e-08 1.40948172776854 0.536363636363636 9.3 9 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00321735735749222 0.00936257570493134 1.407775333425 0.535714285714286 9.3 9 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 5.71055505729702e-10 8.73776327584264e-09 1.40703634374866 0.535433070866142 9.3 9 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 3.04431690231952e-12 1.05660072000016e-10 1.40259333833263 0.533742331288344 9.3 9 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 2.19710696404908e-05 0.000110087436966262 1.40151855416533 0.533333333333333 9.3 9 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00251012238456966 0.00742599616058759 1.40151855416533 0.533333333333333 9.3 9 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0308660548249903 0.0639521523123617 1.40151855416533 0.533333333333333 9.3 9 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0308660548249903 0.0639521523123617 1.40151855416533 0.533333333333333 9.3 9 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0308660548249903 0.0639521523123617 1.40151855416533 0.533333333333333 9.3 9 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.7740751575134e-09 2.4750087736682e-08 1.40008257204016 0.532786885245902 9.3 9 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 1.73954654324722e-08 2.01249978133398e-07 1.39988126613476 0.532710280373832 9.3 9 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000180402002008992 0.00071908136935237 1.39779111120212 0.531914893617021 9.3 9 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 9.41221378113036e-12 2.84969791713798e-10 1.39708336886734 0.531645569620253 9.3 9 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 8.52268608318037e-07 5.74776412150032e-06 1.39307567130891 0.530120481927711 9.3 9 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 6.80714609712353e-08 5.76581481917071e-07 1.3927590632018 0.53 9.3 9 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 6.80714609712353e-08 5.76581481917071e-07 1.3927590632018 0.53 9.3 9 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 4.36399773051957e-09 5.69721905553151e-08 1.39121327067882 0.529411764705882 9.3 9 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00153209257958359 0.00480213158754945 1.39121327067882 0.529411764705882 9.3 9 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00153209257958359 0.00480213158754945 1.39121327067882 0.529411764705882 9.3 9 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00153209257958359 0.00480213158754945 1.39121327067882 0.529411764705882 9.3 9 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00153209257958359 0.00480213158754945 1.39121327067882 0.529411764705882 9.3 9 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.023573563640136 0.0503681397295999 1.39121327067882 0.529411764705882 9.3 9 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.023573563640136 0.0503681397295999 1.39121327067882 0.529411764705882 9.3 9 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.023573563640136 0.0503681397295999 1.39121327067882 0.529411764705882 9.3 9 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 3.46518671625175e-09 4.69615304497737e-08 1.38993575619702 0.528925619834711 9.3 9 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 3.46518671625175e-09 4.69615304497737e-08 1.38993575619702 0.528925619834711 9.3 9 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 6.7824145123733e-06 3.86055034044288e-05 1.389004995646 0.528571428571429 9.3 9 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 8.81423272853615e-05 0.000374407557394237 1.38829668101283 0.528301886792453 9.3 9 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 5.3629885255877e-06 3.17980527996304e-05 1.38691940255944 0.527777777777778 9.3 9 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.13917997744928e-08 2.43524248632826e-07 1.38559220695891 0.527272727272727 9.3 9 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 6.9458607738223e-05 0.000301340240278937 1.38559220695891 0.527272727272727 9.3 9 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 6.9458607738223e-05 0.000301340240278937 1.38559220695891 0.527272727272727 9.3 9 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 4.24100016423099e-06 2.55717933631386e-05 1.38494654423432 0.527027027027027 9.3 9 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 4.24100016423099e-06 2.55717933631386e-05 1.38494654423432 0.527027027027027 9.3 9 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 4.3164410564549e-05 0.000194993511851915 1.38073332137051 0.525423728813559 9.3 9 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 4.3164410564549e-05 0.000194993511851915 1.38073332137051 0.525423728813559 9.3 9 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 4.3164410564549e-05 0.000194993511851915 1.38073332137051 0.525423728813559 9.3 9 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000734904792383805 0.00250784057448958 1.3796198267565 0.525 9.3 9 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000734904792383805 0.00250784057448958 1.3796198267565 0.525 9.3 9 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 3.13307514963754e-15 1.59227354926222e-13 1.37873602161444 0.524663677130045 9.3 9 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 1.65994684330148e-06 1.07368379909909e-05 1.37801748084853 0.524390243902439 9.3 9 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.68485547716626e-05 0.000131743080827848 1.37649143712666 0.523809523809524 9.3 9 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 1.31323542957905e-06 8.65154637171752e-06 1.37649143712666 0.523809523809524 9.3 9 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 1.31323542957905e-06 8.65154637171752e-06 1.37649143712666 0.523809523809524 9.3 9 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00057605588158866 0.00204931879875166 1.37649143712666 0.523809523809524 9.3 9 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 5.22120487461879e-08 4.7626759849888e-07 1.37532194567626 0.523364485981308 9.3 9 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.11815124441814e-05 0.000106889723131306 1.37456627427754 0.523076923076923 9.3 9 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.25023109367898e-55 1.7790788463052e-52 1.37337720310601 0.52262443438914 9.3 9 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 1.67139991898148e-05 8.55540318241238e-05 1.37275604652388 0.522388059701492 9.3 9 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 1.67139991898148e-05 8.55540318241238e-05 1.37275604652388 0.522388059701492 9.3 9 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.67139991898148e-05 8.55540318241238e-05 1.37275604652388 0.522388059701492 9.3 9 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.67139991898148e-05 8.55540318241238e-05 1.37275604652388 0.522388059701492 9.3 9 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.31912990312375e-05 7.0041860154668e-05 1.37105075950956 0.521739130434783 9.3 9 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.31912990312375e-05 7.0041860154668e-05 1.37105075950956 0.521739130434783 9.3 9 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000354558894679949 0.0012903767445769 1.37105075950956 0.521739130434783 9.3 9 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0107216181501281 0.0259029925766252 1.37105075950956 0.521739130434783 9.3 9 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0107216181501281 0.0259029925766252 1.37105075950956 0.521739130434783 9.3 9 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0107216181501281 0.0259029925766252 1.37105075950956 0.521739130434783 9.3 9 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000278384322813123 0.00104247602990283 1.36867046305208 0.520833333333333 9.3 9 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 6.49199338845126e-06 3.71008296858078e-05 1.3664805903112 0.52 9.3 9 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 6.49199338845126e-06 3.71008296858078e-05 1.3664805903112 0.52 9.3 9 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 6.49199338845126e-06 3.71008296858078e-05 1.3664805903112 0.52 9.3 9 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 6.49199338845126e-06 3.71008296858078e-05 1.3664805903112 0.52 9.3 9 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 6.49199338845126e-06 3.71008296858078e-05 1.3664805903112 0.52 9.3 9 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 6.49199338845126e-06 3.71008296858078e-05 1.3664805903112 0.52 9.3 9 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00828829217581391 0.0209117726350766 1.3664805903112 0.52 9.3 9 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 1.26655307088507e-07 1.04785175573805e-06 1.36445916931961 0.519230769230769 9.3 9 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.00017185928674845 0.000686954396188327 1.36445916931961 0.519230769230769 9.3 9 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.00017185928674845 0.000686954396188327 1.36445916931961 0.519230769230769 9.3 9 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 4.05008821571237e-06 2.47676286987839e-05 1.3638194791324 0.518987341772152 9.3 9 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000135119861154583 0.000555709717985465 1.36258748321629 0.518518518518518 9.3 9 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.00642013934557751 0.0171404470708383 1.36258748321629 0.518518518518518 9.3 9 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.00642013934557751 0.0171404470708383 1.36258748321629 0.518518518518518 9.3 9 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00642013934557751 0.0171404470708383 1.36258748321629 0.518518518518518 9.3 9 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000106276710393049 0.000442198125407335 1.3608494889775 0.517857142857143 9.3 9 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.99791189716226e-06 1.26356827984973e-05 1.36029742021929 0.517647058823529 9.3 9 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.57905987113506e-06 1.03073495258036e-05 1.35923135641034 0.517241379310345 9.3 9 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.57905987113506e-06 1.03073495258036e-05 1.35923135641034 0.517241379310345 9.3 9 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 8.36217834771644e-05 0.000358415053879533 1.35923135641034 0.517241379310345 9.3 9 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 8.36217834771644e-05 0.000358415053879533 1.35923135641034 0.517241379310345 9.3 9 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00498183549194775 0.0137386664826388 1.35923135641034 0.517241379310345 9.3 9 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00498183549194775 0.0137386664826388 1.35923135641034 0.517241379310345 9.3 9 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 1.22903558127817e-08 1.49480139500755e-07 1.35630827822451 0.516129032258065 9.3 9 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00387177421501055 0.0109751687409562 1.35630827822451 0.516129032258065 9.3 9 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 4.08175113219129e-05 0.000186164482727827 1.35498375842156 0.515625 9.3 9 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.00301322481576055 0.0088226726601384 1.35373951254606 0.515151515151515 9.3 9 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00234796087657241 0.00705873150016707 1.351464320088 0.514285714285714 9.3 9 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 1.19575910925935e-07 9.95067375716995e-07 1.35008668061798 0.513761467889908 9.3 9 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 9.7995656954315e-06 5.44718046273399e-05 1.34850058254394 0.513157894736842 9.3 9 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00143026289873671 0.00458392816419447 1.34761399438974 0.512820512820513 9.3 9 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 2.93950925144694e-08 3.21763204985307e-07 1.34650026381586 0.512396694214876 9.3 9 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000258796129267812 0.000989964763301335 1.33871465669094 0.509433962264151 9.3 9 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000203213012845621 0.000790087752129287 1.33781316533963 0.509090909090909 9.3 9 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.000203213012845621 0.000790087752129287 1.33781316533963 0.509090909090909 9.3 9 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000203213012845621 0.000790087752129287 1.33781316533963 0.509090909090909 9.3 9 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.000203213012845621 0.000790087752129287 1.33781316533963 0.509090909090909 9.3 9 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 4.61753405037046e-44 3.28537547683858e-41 1.33579433259516 0.508322663252241 9.3 9 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.78516565246747e-05 0.000175449209233264 1.33296601618985 0.507246376811594 9.3 9 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 2.98146348722228e-05 0.000143817713298892 1.33242961135436 0.507042253521127 9.3 9 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.34909804189114e-05 0.00011687994802836 1.33192259856465 0.506849315068493 9.3 9 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.94221683427177e-21 3.04785765640118e-19 1.32797630382978 0.505347593582888 9.3 9 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.53364967496317e-09 2.16077573017088e-08 1.3224005712689 0.503225806451613 9.3 9 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 1.21457706596061e-09 1.78179707717726e-08 1.32229258494102 0.503184713375796 9.3 9 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 5.87422025625049e-11 1.34822829429749e-09 1.32110355515584 0.502732240437158 9.3 9 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.68771647360283e-11 1.02894520430134e-09 1.32094997417989 0.502673796791444 9.3 9 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.301588435705e-12 5.00583876758978e-11 1.31392364453 0.5 9.3 9 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 4.88574687881326e-07 3.42483635889225e-06 1.31392364453 0.5 9.3 9 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.000185129115221197 0.000731774252666008 1.31392364453 0.5 9.3 9 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000382472397381042 0.00138841383028883 1.31392364453 0.5 9.3 9 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0124484974470893 0.0296720466787406 1.31392364453 0.5 9.3 9 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.0161407319675798 0.0372257076010796 1.31392364453 0.5 9.3 9 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0161407319675798 0.0372257076010796 1.31392364453 0.5 9.3 9 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0161407319675798 0.0372257076010796 1.31392364453 0.5 9.3 9 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0273663166410042 0.0573523837704699 1.31392364453 0.5 9.3 9 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0273663166410042 0.0573523837704699 1.31392364453 0.5 9.3 9 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0273663166410042 0.0573523837704699 1.31392364453 0.5 9.3 9 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0471105556196322 0.0934983551558392 1.31392364453 0.5 9.3 9 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.0830069227421734 0.14618669685905 1.31392364453 0.5 9.3 9 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0830069227421734 0.14618669685905 1.31392364453 0.5 9.3 9 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0830069227421734 0.14618669685905 1.31392364453 0.5 9.3 9 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0830069227421734 0.14618669685905 1.31392364453 0.5 9.3 9 3 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.111663749121004 0.186718584017848 1.31392364453 0.5 9.3 9 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.81699500358626e-10 1.3206930410635e-08 1.31392364453 0.5 9.3 9 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 2.72278045280453e-05 0.000133144899805527 1.31392364453 0.5 9.3 9 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 4.38777245157312e-05 0.000195457652325936 1.31392364453 0.5 9.3 9 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 4.38777245157312e-05 0.000195457652325936 1.31392364453 0.5 9.3 9 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 4.38777245157312e-05 0.000195457652325936 1.31392364453 0.5 9.3 9 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.38777245157312e-05 0.000195457652325936 1.31392364453 0.5 9.3 9 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000145494142371285 0.000596651771165241 1.31392364453 0.5 9.3 9 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.00101457312503717 0.00331893691247792 1.31392364453 0.5 9.3 9 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0016597065411413 0.00512312886777456 1.31392364453 0.5 9.3 9 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.0034974754134592 0.0100543586128332 1.31392364453 0.5 9.3 9 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0034974754134592 0.0100543586128332 1.31392364453 0.5 9.3 9 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0358240788503528 0.0731386860890273 1.31392364453 0.5 9.3 9 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0623063960033874 0.117277779778863 1.31392364453 0.5 9.3 9 3 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0623063960033874 0.117277779778863 1.31392364453 0.5 9.3 9 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0623063960033874 0.117277779778863 1.31392364453 0.5 9.3 9 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0623063960033874 0.117277779778863 1.31392364453 0.5 9.3 9 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0623063960033874 0.117277779778863 1.31392364453 0.5 9.3 9 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0623063960033874 0.117277779778863 1.31392364453 0.5 9.3 9 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.45615782690352e-05 0.00012135807596124 1.2977023649679 0.493827160493827 9.3 9 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.45615782690352e-05 0.00012135807596124 1.2977023649679 0.493827160493827 9.3 9 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.11581950217082e-05 0.000147793705052969 1.29729169966253 0.493670886075949 9.3 9 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.11581950217082e-05 0.000147793705052969 1.29729169966253 0.493670886075949 9.3 9 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 3.11581950217082e-05 0.000147793705052969 1.29729169966253 0.493670886075949 9.3 9 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 5.93320931470345e-09 7.53835433466341e-08 1.29707846960012 0.493589743589744 9.3 9 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000268809737885228 0.00102551275337984 1.29238391265246 0.491803278688525 9.3 9 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00115303075444904 0.00372900628086587 1.28710887627428 0.489795918367347 9.3 9 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.7707021671338e-07 1.42356451063921e-06 1.28383379007511 0.488549618320611 9.3 9 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.7707021671338e-07 1.42356451063921e-06 1.28383379007511 0.488549618320611 9.3 9 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.00240926196458961 0.00718737898450947 1.28336728070372 0.488372093023256 9.3 9 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00308537318958929 0.00901537176342004 1.28187672637073 0.48780487804878 9.3 9 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 7.19602170275936e-05 0.000310301178273532 1.27934670651605 0.486842105263158 9.3 9 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000147262154435862 0.000602166798167332 1.276382968972 0.485714285714286 9.3 9 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00652150899533782 0.0173784780905725 1.276382968972 0.485714285714286 9.3 9 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00839052022189581 0.0209319991727565 1.27410777651394 0.484848484848485 9.3 9 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.00839052022189581 0.0209319991727565 1.27410777651394 0.484848484848485 9.3 9 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.00839052022189581 0.0209319991727565 1.27410777651394 0.484848484848485 9.3 9 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.53361195112988e-05 7.99388207493709e-05 1.27153901083548 0.483870967741935 9.3 9 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000384418108679553 0.00139192612888296 1.27153901083548 0.483870967741935 9.3 9 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0108114620846214 0.0260757805871463 1.27153901083548 0.483870967741935 9.3 9 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.06456084979985e-06 1.29994251737398e-05 1.2678210605114 0.482456140350877 9.3 9 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 1.59128119390149e-12 5.95892931295216e-11 1.2675498688407 0.482352941176471 9.3 9 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.94777237309021e-05 0.000180632800222102 1.2675498688407 0.482352941176471 9.3 9 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.94777237309021e-05 0.000180632800222102 1.2675498688407 0.482352941176471 9.3 9 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 3.94777237309021e-05 0.000180632800222102 1.2675498688407 0.482352941176471 9.3 9 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.94777237309021e-05 0.000180632800222102 1.2675498688407 0.482352941176471 9.3 9 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.00101031963814625 0.00331263789189427 1.2652598058437 0.481481481481481 9.3 9 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0180462585413503 0.0410629871113472 1.2652598058437 0.481481481481481 9.3 9 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0180462585413503 0.0410629871113472 1.2652598058437 0.481481481481481 9.3 9 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0180462585413503 0.0410629871113472 1.2652598058437 0.481481481481481 9.3 9 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.83661414548329e-10 3.73357418431818e-09 1.26386941045266 0.480952380952381 9.3 9 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.00164310253414142 0.00508290196974619 1.2613666987488 0.48 9.3 9 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00164310253414142 0.00508290196974619 1.2613666987488 0.48 9.3 9 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0233891379292099 0.05020021609844 1.2613666987488 0.48 9.3 9 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0233891379292099 0.05020021609844 1.2613666987488 0.48 9.3 9 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0233891379292099 0.05020021609844 1.2613666987488 0.48 9.3 9 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0233891379292099 0.05020021609844 1.2613666987488 0.48 9.3 9 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 5.3727228344592e-24 8.49487177048382e-22 1.2597919588003 0.47940074906367 9.3 9 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00209736932684916 0.00643223394850508 1.25917682600791 0.479166666666667 9.3 9 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 4.20245293549502e-15 2.06210018179635e-13 1.2574974757465 0.478527607361963 9.3 9 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 3.71565887236666e-09 4.93889732306531e-08 1.25679652955043 0.478260869565217 9.3 9 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.00267908269720998 0.00790940804591245 1.25679652955043 0.478260869565217 9.3 9 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00438143377908744 0.0122490771466433 1.25135585193333 0.476190476190476 9.3 9 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0396069636786175 0.0801717059952671 1.25135585193333 0.476190476190476 9.3 9 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0396069636786175 0.0801717059952671 1.25135585193333 0.476190476190476 9.3 9 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00561043058712846 0.0153827412822424 1.2482274623035 0.475 9.3 9 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.000875887492749916 0.00290533310532198 1.24711396768949 0.474576271186441 9.3 9 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 3.59593803686032e-09 4.82737719476626e-08 1.24549012137739 0.473958333333333 9.3 9 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00719118374458003 0.0186055535791589 1.2447697685021 0.473684210526316 9.3 9 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0517993923678061 0.101950947910633 1.2447697685021 0.473684210526316 9.3 9 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0517993923678061 0.101950947910633 1.2447697685021 0.473684210526316 9.3 9 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 6.44243050429335e-06 3.71008296858078e-05 1.24353487785875 0.473214285714286 9.3 9 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.84573044666511e-12 6.73454980924217e-11 1.2427725446457 0.472924187725632 9.3 9 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.0092272232528082 0.0227562195645513 1.24092788650055 0.472222222222222 9.3 9 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 1.63780679923004e-05 8.50583604125672e-05 1.23812035734557 0.471153846153846 9.3 9 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0118537763729699 0.0283018855347922 1.23663401838117 0.470588235294118 9.3 9 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0118537763729699 0.0283018855347922 1.23663401838117 0.470588235294118 9.3 9 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0680323262680734 0.125077519740915 1.23663401838117 0.470588235294118 9.3 9 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0680323262680734 0.125077519740915 1.23663401838117 0.470588235294118 9.3 9 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 4.99544554556158e-11 1.31639240950632e-09 1.23049992106777 0.468253968253968 9.3 9 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 4.99544554556158e-11 1.31639240950632e-09 1.23049992106777 0.468253968253968 9.3 9 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 4.99544554556158e-11 1.31639240950632e-09 1.23049992106777 0.468253968253968 9.3 9 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 2.25369347956609e-05 0.000112526520049914 1.22632873489466 0.466666666666667 9.3 9 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.0196430226992089 0.0444388255977334 1.22632873489466 0.466666666666667 9.3 9 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0898166945344847 0.157594520742998 1.22632873489466 0.466666666666667 9.3 9 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0898166945344847 0.157594520742998 1.22632873489466 0.466666666666667 9.3 9 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00609636579169426 0.0164926397748687 1.22225455305116 0.465116279069767 9.3 9 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0253464841213462 0.0534341435624825 1.220071955635 0.464285714285714 9.3 9 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00779116197591231 0.0196924040705563 1.21778289005219 0.463414634146341 9.3 9 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00779116197591231 0.0196924040705563 1.21778289005219 0.463414634146341 9.3 9 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00779116197591231 0.0196924040705563 1.21778289005219 0.463414634146341 9.3 9 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00779116197591231 0.0196924040705563 1.21778289005219 0.463414634146341 9.3 9 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00779116197591231 0.0196924040705563 1.21778289005219 0.463414634146341 9.3 9 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00779116197591231 0.0196924040705563 1.21778289005219 0.463414634146341 9.3 9 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00779116197591231 0.0196924040705563 1.21778289005219 0.463414634146341 9.3 9 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00779116197591231 0.0196924040705563 1.21778289005219 0.463414634146341 9.3 9 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0327668297710276 0.0670894946247082 1.21285259495077 0.461538461538462 9.3 9 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.119349840056862 0.197712249593614 1.21285259495077 0.461538461538462 9.3 9 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.119349840056862 0.197712249593614 1.21285259495077 0.461538461538462 9.3 9 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.119349840056862 0.197712249593614 1.21285259495077 0.461538461538462 9.3 9 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.119349840056862 0.197712249593614 1.21285259495077 0.461538461538462 9.3 9 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00996493035222577 0.0244063612585495 1.21285259495077 0.461538461538462 9.3 9 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00996493035222577 0.0244063612585495 1.21285259495077 0.461538461538462 9.3 9 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00996493035222577 0.0244063612585495 1.21285259495077 0.461538461538462 9.3 9 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0424491861537961 0.0846011090992322 1.20443000748583 0.458333333333333 9.3 9 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.016344106796239 0.0376337604709516 1.201301617856 0.457142857142857 9.3 9 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00338643859712302 0.00977464933814617 1.19447604048182 0.454545454545455 9.3 9 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0209626297137608 0.0461761951744298 1.19447604048182 0.454545454545455 9.3 9 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.159931338569176 0.248995946153105 1.19447604048182 0.454545454545455 9.3 9 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0106078939645938 0.0258712554573872 1.18878805933666 0.452380952380952 9.3 9 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0269160726171045 0.0566591291925143 1.18676974344645 0.451612903225806 9.3 9 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00358541667988857 0.0102450761756655 1.17800050888896 0.448275862068966 9.3 9 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00358541667988857 0.0102450761756655 1.17800050888896 0.448275862068966 9.3 9 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00358541667988857 0.0102450761756655 1.17800050888896 0.448275862068966 9.3 9 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 6.86993953312471e-15 3.25864131854549e-13 1.17251482180031 0.446188340807175 9.3 9 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 4.42940449605361e-06 2.65951164467691e-05 1.16981588996864 0.445161290322581 9.3 9 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0445432867547694 0.0886504853874642 1.16793212847111 0.444444444444444 9.3 9 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0937989242022499 0.162974199193897 1.16793212847111 0.444444444444444 9.3 9 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0937989242022499 0.162974199193897 1.16793212847111 0.444444444444444 9.3 9 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0937989242022499 0.162974199193897 1.16793212847111 0.444444444444444 9.3 9 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0937989242022499 0.162974199193897 1.16793212847111 0.444444444444444 9.3 9 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0937989242022499 0.162974199193897 1.16793212847111 0.444444444444444 9.3 9 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.00196913161605086 0.00606509586502245 1.163760942298 0.442857142857143 9.3 9 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00045786938403041 0.00165367546567328 1.15851332098344 0.440860215053763 9.3 9 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0574249383302566 0.109832912962305 1.1562528071864 0.44 9.3 9 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0180171696875262 0.0410629871113472 1.15368905373366 0.439024390243902 9.3 9 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.0741626293585e-07 2.36461266031197e-06 1.15124738377866 0.438095238095238 9.3 9 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00392809796712228 0.0111126906704076 1.14968318896375 0.4375 9.3 9 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0116338539597348 0.0278703269102738 1.14968318896375 0.4375 9.3 9 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0116338539597348 0.0278703269102738 1.14968318896375 0.4375 9.3 9 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0359912133824857 0.0732696661563335 1.14968318896375 0.4375 9.3 9 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0359912133824857 0.0732696661563335 1.14968318896375 0.4375 9.3 9 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.123032580357148 0.202658471835012 1.14968318896375 0.4375 9.3 9 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.123032580357148 0.202658471835012 1.14968318896375 0.4375 9.3 9 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.123032580357148 0.202658471835012 1.14968318896375 0.4375 9.3 9 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.0011276371497882 0.00366353347979134 1.14388646700259 0.435294117647059 9.3 9 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.0011276371497882 0.00366353347979134 1.14388646700259 0.435294117647059 9.3 9 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0741530186438406 0.134420058000236 1.1425422995913 0.434782608695652 9.3 9 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.39539344654249e-05 0.000195457652325936 1.13687010377773 0.432624113475177 9.3 9 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.79457826091848e-18 3.92651660251762e-16 1.13614548422812 0.432348367029549 9.3 9 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00116820161983071 0.00376950318598434 1.13475223845772 0.431818181818182 9.3 9 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.000152142008597765 0.000620338333050487 1.13232444162748 0.430894308943089 9.3 9 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00220937892214983 0.00673221885700046 1.13097225098785 0.430379746835443 9.3 9 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0370111219122053 0.0752383235443831 1.12622026674 0.428571428571429 9.3 9 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0151678398643871 0.035210405276006 1.12622026674 0.428571428571429 9.3 9 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0589408887298368 0.112430140298335 1.12622026674 0.428571428571429 9.3 9 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.095927435948073 0.164372824220588 1.12622026674 0.428571428571429 9.3 9 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.095927435948073 0.164372824220588 1.12622026674 0.428571428571429 9.3 9 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.162132423096968 0.249961471361848 1.12622026674 0.428571428571429 9.3 9 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.162132423096968 0.249961471361848 1.12622026674 0.428571428571429 9.3 9 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.162132423096968 0.249961471361848 1.12622026674 0.428571428571429 9.3 9 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.162132423096968 0.249961471361848 1.12622026674 0.428571428571429 9.3 9 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.162132423096968 0.249961471361848 1.12622026674 0.428571428571429 9.3 9 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.162132423096968 0.249961471361848 1.12622026674 0.428571428571429 9.3 9 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 3.13124626527125e-15 1.59227354926222e-13 1.12293299217275 0.427320490367776 9.3 9 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.3336368583875e-39 1.18594131237135e-36 1.12137318145168 0.426726920593932 9.3 9 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0298252273204186 0.062322024195236 1.1168350978505 0.425 9.3 9 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.000166026169603345 0.00066738768176712 1.11484430444969 0.424242424242424 9.3 9 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00657763968338617 0.0174912684522143 1.11484430444969 0.424242424242424 9.3 9 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0470649066120724 0.0934983551558392 1.11484430444969 0.424242424242424 9.3 9 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0755075512736912 0.134726606982819 1.11178154537154 0.423076923076923 9.3 9 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.124344038263663 0.203615151264894 1.10646201644631 0.421052631578947 9.3 9 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.124344038263663 0.203615151264894 1.10646201644631 0.421052631578947 9.3 9 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.0598550045041321 0.113716517235487 1.10200047605742 0.419354838709677 9.3 9 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 3.65027816196772e-05 0.0001697498635451 1.10002909774604 0.418604651162791 9.3 9 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0158048011417152 0.036629042385441 1.09891795724327 0.418181818181818 9.3 9 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0477064849702208 0.0943463584885038 1.09493637044166 0.416666666666667 9.3 9 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0967986132795871 0.164372824220588 1.09493637044166 0.416666666666667 9.3 9 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0967986132795871 0.164372824220588 1.09493637044166 0.416666666666667 9.3 9 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0967986132795871 0.164372824220588 1.09493637044166 0.416666666666667 9.3 9 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.214877349874178 0.312170183170486 1.09493637044166 0.416666666666667 9.3 9 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00246793007018885 0.0073469968407505 1.09027706673766 0.414893617021277 9.3 9 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0761210063346354 0.134726606982819 1.08738508512827 0.413793103448276 9.3 9 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0761210063346354 0.134726606982819 1.08738508512827 0.413793103448276 9.3 9 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0761210063346354 0.134726606982819 1.08738508512827 0.413793103448276 9.3 9 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0306793892182797 0.063919137419637 1.08541518461174 0.41304347826087 9.3 9 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.161532758219499 0.249961471361848 1.08205476608353 0.411764705882353 9.3 9 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.161532758219499 0.249961471361848 1.08205476608353 0.411764705882353 9.3 9 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.161532758219499 0.249961471361848 1.08205476608353 0.411764705882353 9.3 9 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 8.47799821503539e-21 8.04279430666357e-19 1.078495884399 0.41041041041041 9.3 9 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.124174502975703 0.203615151264894 1.07502843643363 0.409090909090909 9.3 9 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.124174502975703 0.203615151264894 1.07502843643363 0.409090909090909 9.3 9 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.124174502975703 0.203615151264894 1.07502843643363 0.409090909090909 9.3 9 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.030875002556987 0.0639521523123617 1.07259073022857 0.408163265306122 9.3 9 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.09679548313045 0.164372824220588 1.07060445109852 0.407407407407407 9.3 9 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.09679548313045 0.164372824220588 1.07060445109852 0.407407407407407 9.3 9 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0603863983973582 0.114573126559254 1.06534349556486 0.405405405405405 9.3 9 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0031636357518362 0.00922510998947318 1.0560507797157 0.401869158878505 9.3 9 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 9.22651796662185e-05 0.000389594512359136 1.05380678089208 0.401015228426396 9.3 9 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.0384620451375956 0.078076305607416 1.051138915624 0.4 9.3 9 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0961737412008067 0.164372824220588 1.051138915624 0.4 9.3 9 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0961737412008067 0.164372824220588 1.051138915624 0.4 9.3 9 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.123047729912474 0.202658471835012 1.051138915624 0.4 9.3 9 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.159380003312949 0.248995946153105 1.051138915624 0.4 9.3 9 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.159380003312949 0.248995946153105 1.051138915624 0.4 9.3 9 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.159380003312949 0.248995946153105 1.051138915624 0.4 9.3 9 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.159380003312949 0.248995946153105 1.051138915624 0.4 9.3 9 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.21034290880529 0.312170183170486 1.051138915624 0.4 9.3 9 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.91256415723371e-05 0.000141937629991218 1.04888325271493 0.399141630901288 9.3 9 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.000201012751790988 0.000790087752129287 1.04018955191958 0.395833333333333 9.3 9 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0477367379562352 0.0943463584885038 1.04018955191958 0.395833333333333 9.3 9 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0477367379562352 0.0943463584885038 1.04018955191958 0.395833333333333 9.3 9 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0131564879508386 0.0313071611271628 1.03816189197432 0.395061728395062 9.3 9 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.0951095323213035 0.164372824220588 1.03521256841757 0.393939393939394 9.3 9 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0306011410661857 0.0638495949225546 1.03390713012196 0.39344262295082 9.3 9 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.121289632448494 0.200692031365357 1.032368577845 0.392857142857143 9.3 9 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.000946764233651743 0.00311862385297785 1.02828806963217 0.391304347826087 9.3 9 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.0591567646573864 0.112540208699814 1.02828806963217 0.391304347826087 9.3 9 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0591567646573864 0.112540208699814 1.02828806963217 0.391304347826087 9.3 9 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 1.96240439952785e-08 2.25201730687752e-07 1.02550138109658 0.390243902439024 9.3 9 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00113736126312113 0.00368670860460448 1.02194061241222 0.388888888888889 9.3 9 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.204636107139567 0.304918513570266 1.02194061241222 0.388888888888889 9.3 9 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.119111890693443 0.197712249593614 1.01723120866838 0.387096774193548 9.3 9 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.119111890693443 0.197712249593614 1.01723120866838 0.387096774193548 9.3 9 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.119111890693443 0.197712249593614 1.01723120866838 0.387096774193548 9.3 9 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 5.6441414885988e-08 5.05132914356987e-07 1.01397743880901 0.385858585858586 9.3 9 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.019282870991993 0.043693511817844 1.01314594277012 0.385542168674699 9.3 9 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0575664156134649 0.109955717339544 1.01071049579231 0.384615384615385 9.3 9 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0921171034481304 0.1610351820721 1.01071049579231 0.384615384615385 9.3 9 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.152760341561713 0.241799739757861 1.01071049579231 0.384615384615385 9.3 9 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.152760341561713 0.241799739757861 1.01071049579231 0.384615384615385 9.3 9 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.27458204351 0.386828040262641 1.01071049579231 0.384615384615385 9.3 9 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.27458204351 0.386828040262641 1.01071049579231 0.384615384615385 9.3 9 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0566327161275006 0.108463465746209 1.00335987400472 0.381818181818182 9.3 9 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0566327161275006 0.108463465746209 1.00335987400472 0.381818181818182 9.3 9 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.19842773707595 0.296288216011624 1.00108468154666 0.380952380952381 9.3 9 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.19842773707595 0.296288216011624 1.00108468154666 0.380952380952381 9.3 9 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0884596154850103 0.155597073961891 0.992742309200442 0.377777777777778 9.3 9 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00331609484767569 0.00959106294358233 0.991640486437733 0.377358490566038 9.3 9 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00331609484767569 0.00959106294358233 0.991640486437733 0.377358490566038 9.3 9 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00938225625842547 0.023098530546262 0.990827666366883 0.377049180327869 9.3 9 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.000282686037735868 0.00105580638240982 0.989307214704939 0.376470588235294 9.3 9 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.144869308157091 0.231628118547798 0.985442733397498 0.375 9.3 9 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.192050706391861 0.28736924836553 0.985442733397498 0.375 9.3 9 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.192050706391861 0.28736924836553 0.985442733397498 0.375 9.3 9 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.262729105874176 0.375364977569229 0.985442733397498 0.375 9.3 9 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.262729105874176 0.375364977569229 0.985442733397498 0.375 9.3 9 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0249329791100319 0.0526403995156905 0.972303496952198 0.37 9.3 9 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.0489990219297424 0.0967068074979521 0.968154264390524 0.368421052631579 9.3 9 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.251473147317177 0.360006326591895 0.968154264390524 0.368421052631579 9.3 9 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00766871434572949 0.0196623072323839 0.966369648234965 0.367741935483871 9.3 9 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0135884402864699 0.0320669162979216 0.957287226728998 0.364285714285714 9.3 9 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.173303465777541 0.266031102266926 0.955580832385452 0.363636363636364 9.3 9 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.173303465777541 0.266031102266926 0.955580832385452 0.363636363636364 9.3 9 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.167376958203983 0.2577677613899 0.948944854382775 0.361111111111111 9.3 9 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0917894636586589 0.160659786944984 0.947748202611801 0.360655737704918 9.3 9 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.230864880661517 0.331839116344786 0.946025024061598 0.36 9.3 9 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0180642515331717 0.0410629871113472 0.943804308042674 0.359154929577465 9.3 9 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.117168229551754 0.195692946774819 0.942058462115847 0.358490566037736 9.3 9 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0217919641100027 0.047928848421227 0.9398869865981 0.357664233576642 9.3 9 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.221453743228382 0.318633646727996 0.938516888949998 0.357142857142857 9.3 9 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.337054054850574 0.452052705044644 0.938516888949998 0.357142857142857 9.3 9 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.337054054850574 0.452052705044644 0.938516888949998 0.357142857142857 9.3 9 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.337054054850574 0.452052705044644 0.938516888949998 0.357142857142857 9.3 9 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0151679398694249 0.035210405276006 0.93506222555509 0.355828220858896 9.3 9 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0292274054131537 0.061162643974879 0.92747551378588 0.352941176470588 9.3 9 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.20420173248097 0.304590215220566 0.92747551378588 0.352941176470588 9.3 9 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.317927113685817 0.427608962925253 0.92747551378588 0.352941176470588 9.3 9 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.13601211611908 0.21771118249432 0.924612935039627 0.351851851851852 9.3 9 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0332375310597967 0.0679554693938085 0.920705619524669 0.35036496350365 9.3 9 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.301061763319454 0.412262759931122 0.919746551170998 0.35 9.3 9 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.285939215274897 0.398154691012626 0.914033839673041 0.347826086956522 9.3 9 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0755511051208572 0.134726606982819 0.912831163568208 0.347368421052632 9.3 9 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.168455645889505 0.259148523352179 0.911702120694283 0.346938775510204 9.3 9 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.100688583660683 0.170774558461444 0.908391655477529 0.345679012345679 9.3 9 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.0913415942834182 0.160072769292246 0.905147399565109 0.344444444444444 9.3 9 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.130974291191092 0.212125331009524 0.900976213391998 0.342857142857143 9.3 9 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0131890751954131 0.0313323105226591 0.897056303494375 0.34136546184739 9.3 9 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0700844834540093 0.128684154780716 0.889743570311651 0.338582677165354 9.3 9 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.23821092028758 0.341707801985108 0.875949096353331 0.333333333333333 9.3 9 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.299758576570009 0.411734029400697 0.875949096353331 0.333333333333333 9.3 9 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.299758576570009 0.411734029400697 0.875949096353331 0.333333333333333 9.3 9 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.299758576570009 0.411734029400697 0.875949096353331 0.333333333333333 9.3 9 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.315481090546185 0.424720522088194 0.875949096353331 0.333333333333333 9.3 9 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.400409627873217 0.526115328221226 0.875949096353331 0.333333333333333 9.3 9 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.400409627873217 0.526115328221226 0.875949096353331 0.333333333333333 9.3 9 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.400409627873217 0.526115328221226 0.875949096353331 0.333333333333333 9.3 9 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.374572616958942 0.498612566821866 0.875949096353331 0.333333333333333 9.3 9 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.380892217506957 0.506551051880747 0.840911132499198 0.32 9.3 9 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.243103138805083 0.348374387230245 0.831597243373416 0.316455696202532 9.3 9 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.431387756793603 0.556676700168252 0.829846512334735 0.315789473684211 9.3 9 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.232349228476831 0.33363567318116 0.822861272331917 0.313131313131313 9.3 9 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.462991683327326 0.595400902380419 0.821202277831248 0.3125 9.3 9 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.462991683327326 0.595400902380419 0.821202277831248 0.3125 9.3 9 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.462991683327326 0.595400902380419 0.821202277831248 0.3125 9.3 9 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.308752841809627 0.416056149521874 0.818509811346555 0.311475409836066 9.3 9 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.263565080663018 0.376181654747718 0.808568396633844 0.307692307692308 9.3 9 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.000567916076928736 0.00202542500618945 0.807582337613559 0.307317073170732 9.3 9 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.338777528362427 0.453936368041181 0.799779609713911 0.304347826086957 9.3 9 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.420199506087846 0.545329533140355 0.78276302227319 0.297872340425532 9.3 9 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.523435254011288 0.650571828086094 0.772896261488234 0.294117647058824 9.3 9 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.397527471628061 0.523779251969195 0.752842736865836 0.286486486486487 9.3 9 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.556123918590321 0.685163927406084 0.735797240936798 0.28 9.3 9 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.580669985564397 0.712936487884501 0.716685624289089 0.272727272727273 9.3 9 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.591123042100996 0.725144904232515 0.710228997043241 0.27027027027027 9.3 9 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.619546706193383 0.743497992785612 0.698541684433669 0.265822784810127 9.3 9 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.634012384995477 0.757514377706603 0.691538760278946 0.263157894736842 9.3 9 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.646923133443572 0.772291626585741 0.681293741608146 0.259259259259259 9.3 9 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.65308571308891 0.778994945285431 0.678154139112256 0.258064516129032 9.3 9 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.685047197095249 0.815068696878378 0.656961822264998 0.25 9.3 9 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.687933104790884 0.817818553147392 0.656961822264998 0.25 9.3 9 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.793927968419036 0.917757513452712 0.656961822264998 0.25 9.3 9 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.766897663462994 0.893040405161899 0.650189019973607 0.247422680412371 9.3 9 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.79090628765665 0.915727302255413 0.629202872028449 0.23943661971831 9.3 9 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.788844100958339 0.914853427598791 0.600650808927999 0.228571428571429 9.3 9 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.766867364371551 0.893040405161899 0.597238020240908 0.227272727272727 9.3 9 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.830187322261513 0.946599807354273 0.59498429186264 0.226415094339623 9.3 9 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.791528167093575 0.915727302255413 0.593384871723224 0.225806451612903 9.3 9 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.791528167093575 0.915727302255413 0.593384871723224 0.225806451612903 9.3 9 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.948406667304574 1 0.593384871723224 0.225806451612903 9.3 9 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.866791371942188 0.974284456772302 0.541027383041763 0.205882352941176 9.3 9 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.859461064657604 0.966883527869373 0.525569457811999 0.2 9.3 9 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.930914365452272 1 0.484077132195262 0.184210526315789 9.3 9 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999992696105248 1 0.480868962688813 0.182989690721649 9.3 9 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999642514717997 1 0.472285918310321 0.179723502304147 9.3 9 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.973314441768781 1 0.437974548176666 0.166666666666667 9.3 9 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.955083023158561 1 0.42384633694516 0.161290322580645 9.3 9 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999998140585927 1 0.422332600027499 0.160714285714286 9.3 9 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.998725432292192 1 0.413642628833518 0.157407407407407 9.3 9 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.379504394389856 0.144416456759026 9.3 9 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.980495359041425 1 0.375406755579999 0.142857142857143 9.3 9 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.989490158409002 1 0.366676365915348 0.13953488372093 9.3 9 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.99987096495351 1 0.321181335329555 0.122222222222222 9.3 9 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.301750999738354 0.114828209764919 9.3 9 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999955040169 1 0.298619010120454 0.113636363636364 9.3 9 3